PMID- 1012526
TI  - [The herniotomy operation in the treatment of congenital inguinal hernia].
AB  - --203 cases of congenital inguinal hernia operated with Mitchell-Banks technique
      have been studied. Just over half the patients were less than 1-year old; 48%
      were males; right inguinal hernia (53%) predominated, while 13% presented
      bilateral hernia. Post-operative hospitalization was 1-3 days in 73% of cases.
      Fever was observed in 86% of the children but it never lasted more than 2 days.
      81 patients presented scrotal haematoma. Mortality was nil. Long-term follow-up
      showed that only 1% had suffered a recurrence. As a result of all these
      advantages and the low hospitalization (one day surgery), the technique is
      recommended for the treatment of infant inguinal hernia.

PMID- 1012527
TI  - [Clinical contribution to the study of pheochromocytomas].
AB  - 6 cases of suprarenal phaeochromocytoma were operated on at the Department of
      Special Surgical Pathology and Clinical Propaedeutics of the University of Turin
      between 1954 and 1975. The age of the patients was between 32 and 53, 5 cases
      being male and 1 female. Personal data are compared with larger series and
      mention is made of the importance of certain pharmacological tests and new
      radiological techniques for the diagnosis of tumour nature and localization. An
      atypical case in which exact clinical classification was only possible
      histologically a posteriori is discussed. Immediate and long-term results were
      good. Although not all patients presented normalised pressure values, the
      disappearance of hypertensive crises and normalization of glycaemia and urinary
      catecholamines were constant observations.

PMID- 1012528
TI  - [Acute renal failure and acute abdomen].
AB  - A series of patients with acute renal failure (ARF) and acute abdomen collected
      by the St. John the Baptist Hospital's Nephrology and Dialysis Division over the
      period 1970-75 is examined. A high rate of mortality was noted, due to causes
      that were mostly independent of ARF Death was often related to failure to resolve
      acute abdomen. The progression of ARF appeared to be related to that of the
      abdominal affection with prompt resolution of the latter. These findings suggest
      that constriction of the afferent arteriole may offer a partial, functional basis
      for ARF with the corollary that it has a good chance of being reversed, even
      after protracted periods of anuria. Renal complications associated with
      disseminated or localised intravascular coagulation appear to be rare. Treatment
      was best directed to early and frequent dialysis, with surgical resolution
      whenever indicated, irrespective of the presence of ARF.

PMID- 1012529
TI  - [Flowmetric changes induced by glucagon in the mesenteric artery region during
      experimental hemorrhagic shock in dogs].
AB  - The pharmacological action of glucagon in the regulation of systemic and
      mesenteric district haemodynamics, in line with the approach that has come to the
      fore in recent years for treating haemorrhagic shock with vasodilators, suggested
      a study of the effects of glucagon on mesenteric haemodynamics during haemorhagic
      shock in dogs. It was shown that the infusion of glucagon increases mesenteric
      arterial flow and peripheral resistances are reduced without particular systemic
      modifications.

PMID- 1012530
TI  - [Acute pancreatitis. Review of cases and considerations on personal experience].
AB  - A series of cases of acute pancreatitis treated between 1-XI-1972 and 1-XI-1975
      is presented. A division is made between cases acute ab initio and postoperative
      pancreatitis, the latter further subdivided into pancreatic necroses, oedemas,
      and slight affections. The question of diagnosis is examined and elements
      indicative of prognosis are stressed. Results obtained in the surgical and
      medical management of 59 ab initio, 3 necrosis, 11 oedemas, and 79 slight
      involvement cases are described.

PMID- 1012531
TI  - [Chylothorax caused by a retroperitoneal neoplasm].

PMID- 1012532
TI  - [Cysts and pseudocyts of the adrenals. Apropos of a case].

PMID- 1012533
TI  - [A complication of opaque clyster: perforation of the colon with escape of barium
      into the peritoneum].

PMID- 1012534
TI  - [Surgical treatment of peripheral arterial embolism].

PMID- 1012535
TI  - [Surgical treatment of acute venous thrombosis of the limbs].

PMID- 1012536
TI  - [Surgical treatment of severe pulmonary embolism].

PMID- 1012537
TI  - [Traumatic rupture of the thoracic aorta].

PMID- 1012538
TI  - [Surgical treatment of ruptured aneurysms of the subrenal aorta].

PMID- 1012539
TI  - [Surgical treatment of acute dissections of the aorta].

PMID- 1012540
TI  - [Diagnosis and treatment of acute obstruction of the celiac tripod].

PMID- 1012541
TI  - [Anesthesia problems in emergency vascular surgery].

PMID- 1012542
TI  - [Etiology and pathogenesis of neoplasms and dysplasia of the breast].

PMID- 1012543
TI  - [Physical symptomatology of the breast].

PMID- 1012544
TI  - [Thermographic symptomatology of the breast].

PMID- 1012545
TI  - [Personal experience in screening for breast cancer].

PMID- 1012546
TI  - Present knowledge of breast cancer.

PMID- 1012547
TI  - [Tumorectomy].

PMID- 1012548
TI  - [Radical mastectomy].

PMID- 1012549
TI  - [Extended mastectomy].

PMID- 1012550
TI  - Bilateral breast cancer what about the other breast?

PMID- 1012551
TI  - [Criteria of radiotherapy of breast cancer].

PMID- 1012552
TI  - [Correlations between determinations of the hormone dependence of breast tumors
      and their treatment].

PMID- 1012553
TI  - [Host resistance and long-term survival in breast cancer].

PMID- 1012554
TI  - [Treatment of metastases from breast cancer].

PMID- 1012555
TI  - [Breast pathology and plastic surgery].

PMID- 1012556
TI  - [Ablative endocrine treatment of advanced or metastasizing breast cancer.
      Criteria of patient selection].

PMID- 1012557
TI  - [Winiwarter-Buerger thromboangiitis obliterans].

PMID- 1012559
TI  - [Congenital cysts of the esophagus].

PMID- 1012558
TI  - [Use of transhepatic drainage in neoplastic stenosis of the upper biliary tract].
AB  - Rodney-Smith's technique (transtumoral transhepatic drainage) was used
      palliatively in 6 patients with cancer of the upper biliary tracts. Diagnosis
      from the symptomatology (essentially obstructive icterus) was not easy, though
      the picture can almost always be clarified by endovenous and endoscopic
      retrograde cholangiography and, more particularly, by preoperative and
      intrahepatic intraoperative cholangiography and choledochoscopy in connection
      with laparatomy. Two patients survived for 9 months and 2 yr respectively,
      whereas the remainder died within 30 days of surgery. Despite this high
      mortality, primarily due to very poor general condition, this type of palliative
      operation is still the best form of management.

PMID- 1012560
TI  - [Spontaneous bilio-digestive fistulas. Experience with 27 cases].
AB  - A series of 27 cases of biliary-digestive fistulae is presented. 26 were due to
      calculi and 1 to ulcer and calculi. 20 led to the duodenum, 6 to the colon, and 1
      to the stomach from the gallbladder. The series constituted 1.4% of bile ducts
      operations. Females (mostly multiparae) formed 66%. The mean age was 64 yr.
      Direct fistulae (66%) had the appearance of surgical openings, whereas the
      indirect forms (34%) included a fistulous connection between the mucosae of the
      two organs. There was no distinctive symptomatology. In most cases, the fistula
      was formed during a serious exacerbation episode of the underlying diseases,
      whose symptoms, if occasional, tended to become continuous. Pre-operative
      diagnosis was difficult, though suspicion was present in 44% of cases.
      Radiological examination is essential for this purpose. Pneumoangiocholia
      observed during direct examination of the abdomen is virtually pathognomonic.
      Examination of the bile ducts with contrast medium given venously or per os
      proved less useful, since the fistula was very difficult to detect; at best,
      pneumocholecyst between the main duct and the opposing duodenum could be seen.
      Detection was, on the other hand, possible in over 50% of cases on examination of
      the digestive apparatus with contrast medium per os or rectally. Treatment
      consists of removal of the fistula and the disease responsible for it. Very good
      results were obtained, with a mortality of 3%.

PMID- 1012561
TI  - [Anal fissure. Review of 83 cases].

PMID- 1012562
TI  - [Reconstructive surgery of the superior vena cava].

PMID- 1012563
TI  - [Metabolic disorder syndromes connected with vascular surgery].

PMID- 1012564
TI  - [Current views on the physiopathology of the inferior esophageal sphincter].

PMID- 1012565
TI  - Abdominal angina. Diagnosis and surgical treatment.

PMID- 1012566
TI  - [Polypectomy and other endoscopic therapeutic methods].

PMID- 1012567
TI  - [Treatment of intra-thoracic foreign bodies].

PMID- 1012568
TI  - [Current trends in the surgical treatment of duodenal ulcer].

PMID- 1012569
TI  - [Notes on Oddi's sphincterotomy].

PMID- 1012570
TI  - [Neural surgery in pancreatic diseases].

PMID- 1012571
TI  - [Adenolymphoscintigraphy in the diagnosis of latero-cervical metastases].

PMID- 1012572
TI  - [Current status of the surgical treatment of cancer of the breast].

PMID- 1012573
TI  - [Omphalo-caval anastomosis in Cruveilhier-Baumgarten syndrome].

PMID- 1012574
TI  - [Surgical treatment of vascular malformations of the limbs].

PMID- 1012575
TI  - [Femoral angioplasty in aorto-femoral bypass].

PMID- 1012576
TI  - [Experience in the treatment of severe obesity by jejuno-ileal short-circuiting].

PMID- 1012577
TI  - [An old problem for present-day gynecology: carcinoma of the endometrium.
      Preventive aspects].

PMID- 1012578
TI  - [The obstetric risk of the 2n twin. Clinico-statistical considerations on 108
      cases of twin pregnancy].

PMID- 1012580
TI  - [Anxiety in the parturient woman].

PMID- 1012579
TI  - [Gestoses at the Maternita di Firenze, Clinico-statistical aspects].

PMID- 1012581
TI  - [Chorionic neoplasms and our experience with a case of chorionepithelioma and one
      of simple hydatidiform mole].

PMID- 1012582
TI  - [Histological examination of the surgical specimen after hysterectomy in patients
      previously conized for intraepithelial neoplastic lesions of the cervix uteri.
      The problem of cytological recurrence and the incomplete cone].

PMID- 1012583
TI  - [Ultrastructure of the human testicle in intersexual syndromes. Observations in
      Morris' syndrome].

PMID- 1012584
TI  - [Collateral circulations in lymphographic diagnosis].

PMID- 1012585
TI  - [Use of LU 52 (ritodrine HC1) in threatened premature labor].

PMID- 1012586
TI  - [A new spasmolytic in the hysterosalpingographic study of female sterility].

PMID- 1012587
TI  - [Treatment of hypogalactia with a placental extract. Clinical study].

PMID- 1012588
TI  - [An old problem for modern gynecology: carcinoma of the endometrium. Therapeutic
      aspects].

PMID- 1012589
TI  - [Computerized handling of data in perinatal medicine].

PMID- 1012590
TI  - [Hormonal and metabolic changes in surgically castrated women before and after
      administration of a non-steroid plant estrogen].

PMID- 1012591
TI  - [Relation between fetal heart rate and acid-base equilibrium during labor].

PMID- 1012592
TI  - [Preliminary evaluation of an endocervical aspirator for the study of exfoliative
      cytology of the endocervix and endometrium].

PMID- 1012593
TI  - [Individuality of the product of conception].

PMID- 1012594
TI  - [Individuality of the product of conception].

PMID- 1012595
TI  - [Scope of the indications for abortion].

PMID- 1012596
TI  - [Eugenic indications in the current status of abortion].

PMID- 1012597
TI  - [Medico-legal aspects of therapeutic abortion].

PMID- 1012598
TI  - [Role and responsibility of the obstetrician in performing an abortion].

PMID- 1012599
TI  - [Individuality of the product of conception].

PMID- 1012600
TI  - [Eugenic indications; problems provoked by present-day genetics].

PMID- 1012602
TI  - [Abortion as a public health argument].

PMID- 1012601
TI  - [Therapeutic abortion: extensions and restrictions of current indications].

PMID- 1012603
TI  - [Risks and sequelae of induced abortion].

PMID- 1012604
TI  - [Criminologic considerations concerning criminal abortion].

PMID- 1012605
TI  - [Role of the obstetrician in performing an abortion. Objections of conscience].

PMID- 1012606
TI  - [Proposed laws on abortion for the consideration of Parliament].

PMID- 1012607
TI  - [Problems and risks of the legalization of abortion].

PMID- 1012608
TI  - [Sexology and abortion with respect to their psychological and socioeconomic
      repercussions].

PMID- 1012609
TI  - [Sociologic, ethical and psychological aspects of abortion].

PMID- 1012610
TI  - [Abortion in the moral reflections of the Catholic physician].

PMID- 1012611
TI  - [Preliminary observations on the use of difluoromethyl-1,1,2-trifluoro-2
      chloroethylether (ethrane) as inhalation anesthetic during labor].

PMID- 1012612
TI  - [Control of arterial hypertension in human chronic renal failure. Indirect
      evidence for a complex pathogenetic mechanism other than renin and sodium].

PMID- 1012613
TI  - [Cerebral metabolism of glutamine in normal humans and those with metabolic
      acidosis].

PMID- 1012614
TI  - [Carbohydrate-lipid metabolism in chronic renal failure. Considerations on some
      blood lipid parameters examined during conservative and dialysis treatment].

PMID- 1012615
TI  - Assessment of total and selective ERPF for each kidney using radioisotope
      techniques.

PMID- 1012616
TI  - [Tomographic verification in the diagnosis of chronic pyelonephritis].

PMID- 1012617
TI  - [Possibilities of the use of a "single needle" in a dialysis center].

PMID- 1012618
TI  - [Anterior vitrectomy and excision of adhesions during extraction of complicated
      traumatic cataracts].

PMID- 1012619
TI  - [Results of the closed vitrectomy operation under clinical conditions].

PMID- 1012620
TI  - [Surgery of the vitreous body during removal of intraocular foreign bodies].

PMID- 1012621
TI  - [2-stage method of corneal prosthesis].

PMID- 1012622
TI  - [Essential element of the glaucomatous process neglected in clinical practice].

PMID- 1012623
TI  - [Clinical characteristics of patients with glaucoma with different types of
      hereditary transmission].

PMID- 1012624
TI  - [Dynamics of the level of sex chromatin in uveitis].

PMID- 1012625
TI  - [Remote results of the use of immunosuppressive agents in complex treatment of
      severe forms of uveitis].

PMID- 1012626
TI  - [Changes in the ciliary body after penetrating eye injuries].

PMID- 1012628
TI  - [Prespasm of accommodation].

PMID- 1012627
TI  - [Changes of eye hydrodynamics in blunt injuries].

PMID- 1012629
TI  - [Early surgical aid in complex treatment of non-paralytic convergent strabismus].

PMID- 1012630
TI  - [Comparative results of surgical treatment of retinal detachment with inferior
      retinal dialysis and with or without subretinal fluid drainage].

PMID- 1012631
TI  - [Effect of ultrasonics on histological and histochemical changes in the process
      of healing of suppurative corneal ulcers].

PMID- 1012632
TI  - [Ultrastructure of the capillaries of human iris].

PMID- 1012633
TI  - [Accommodation disorders in amblyopia with correct fixation and the results of
      their treatment].

PMID- 1012634
TI  - [Penalization].

PMID- 1012635
TI  - [Canaliculodacryocystostomy in obstruction of medial end of the lacrimal duct].

PMID- 1012636
TI  - [Use of stereomicroscope MBS-2 in microsurgery].

PMID- 1012637
TI  - [Miniature ultrasonic head for treatment with ultrasound and electrophoresis].

PMID- 1012638
TI  - [Aspartate aminotransferase of the blood and crystalline lens in naphthalene
      induced cataract formation].

PMID- 1012639
TI  - [Treatment of epidemic conjunctivitis].

PMID- 1012641
TI  - [Traumatic posterior lenticonus].

PMID- 1012640
TI  - [Certain characteristics of eye changes in patients with pheochromocytoma
      including Sipple's syndrome].

PMID- 1012642
TI  - Main issues in oncology.

PMID- 1012643
TI  - Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients
      and normal controls.
AB  - A radiometric assay for the determination of AHH activity in lymphocytes is
      described. Subjects included eleven male patients with histologically verified
      lung cancer (nine squamous cell carcinoma and two adenocarcinoma) and eleven age-
      and sex-matched controls. Lung cancer patients exhibited considerably greater
      variation and elevated levels of both AHH activity per se and AHH activity
      adjusted for total cellular DNA than control individuals. Methodology for AHH
      determinations and implications for lung cancer epidemiology and control are
      discussed.

PMID- 1012644
TI  - Effects of some low molecular weight sheep pineal fractions and melatonin on
      different tumors in rats and mice.
AB  - With these preliminary experiments attention is drawn to a possible relation
      between tumor development and the pineal. The influence of melatonin and some low
      molecular weight pineal fractions on the growth and incidence of different
      experimental tumors was compared. Some pineal fractions which have an effect on
      the activity of hypothalamus on anterior hypophyses of male rats and mice in
      vitro may be active in some of these tumor models.

PMID- 1012645
TI  - Studies of a transplantable rat pheochromocytoma.
AB  - A transplantable rat pheochromocytoma in New England Deaconess Hospital (NEDH)
      was first described by WARREN in 1972. It is characterized by the documented
      association with systolic hypertension and the known presence of increased
      urinary metanephrines and vanilmadelic acid in tumor-bearing animals. The present
      report describes features of the transplantable tumor, our laboratories have
      noted, in five tumor transplantations starting in 1974. Tumor-bearing animals
      survive 49 +/- 5 days and die much sooner than aging, non-tumor-bearing litter
      mates. Gross measurements confirm the rapid growth of the primary tumor, although
      at autopsy, histologically proven metastatic foci are rarely seen. Polycythemia
      with or without increased erythropoietin (ESF) levels were not detected.
      Electronmicroscopic studies confirmed the presence in tumor tissue of the
      previously described intracytoplasmic granules. Further studies on this endocrine
      associated transplantable tumor are warranted and feasible.

PMID- 1012646
TI  - Etiologic related studies of ultraviolet light-mediated carcinogenesis.
AB  - Comparisons were made of cholesterol-5alpha, 6alpha-epoxide (CAE) levels in skin
      of hairless mice maintained on a regular or antioxidant supplemented diet and
      receiving chronic ultraviolet light (UVL) radiation over an 18-week period.
      Cholesterol-5alpha, 6alpha-epoxide levels in skin of animals on antioxidant
      supplemented diet, while reaching a peak four weeks after that of animals on
      regular diet, thereafter were consistently higher. Dietary antioxidants
      nevertheless had an inhibitory effect on UVL-induced tumors. These data are
      inconsistent with the theory of CAE involvement as an ultimate carcinogen in UVL
      mediated carcinogenesis.

PMID- 1012647
TI  - Early onset of oral cancer among women who drink and smoke.
AB  - Potentially, one of the most useful warning signals for the detection of
      environmental hazards is an unusually early age at onset of disease. Animal
      studies have shown age effects of this type with co-carcinogens. A clearcut
      example of a downward age shift in humans is provided by a study of the
      consumption of alcoholic beverages and cigarettes in women with oral concer.
      Using data on 145 white females with intraoral cancer, and 1973 non-neoplastic
      controls from patients seen at Roswell Park Memorial Institute between 1957 and
      1966, it can be shown that exposure to both alcohol and tobacco can lead to onset
      of oral cancer 15 or more years earlier than would occur in women who do not use
      either alcohol or tobacco. Exposure to smoking only produces a smaller age shift,
      but exposure to alcohol only does not produce any clear shift in age of onset.
      Implications for co-carcinogenesis and for early detection of co-carcinogens in
      the environment are suggested.

PMID- 1012648
TI  - Evaluation of VP-16 and the combination of adriamycin and vincristine in advanced
      breast cancer.
AB  - 39 previously treated patients with metastatic breast cancer were treated in a
      partially randomized study evaluating VP-16 and the combination of Vincristine
      (VCR) and Adriamycin (ADR). Of the 19 patients treated with VP-16 initially, two
      had partial remissions. No responses were noted in eleven patients who corssed
      over after failing VCR plus ADR. Of the 20 patients treated with VCR plus ADR
      initially, four patients had partial responses. An additional 2/15 patients
      responded on crossover after failing initially on VP-16. No significant
      differences in time to last follow-up or death could be detected between the two
      treatment programs.

PMID- 1012649
TI  - Ixodes (Afrixodes) Bakeri Arthur & Clifford, 1961 (Acarina: Ixodidae):
      description of the male and immature stages from rodents and insectivores and
      notes on its biology in South Africa.
AB  - The male, nymph and larva of Ixodes (A), bakeri are described and illustrated
      with line drawings and scanning electron microscope photographs. This species was
      originally described from 1 female from Otomys sp., Nyika Plateau, Malawi. The
      present material consists of 28 collections from insectivores and 19 collections
      from rodents, Van Riebeeck Nature Reserve, Transvaal, plus 1 collection from a
      rodent in the Jonkershoek Valley, Cape Province, Republic of South Africa. Its
      biology in South Africa is also discussed.

PMID- 1012650
TI  - Leukoencephalomalacia: a mycotoxicosis of Equidae caused by Fusarium moniliforme
      Sheldon.
AB  - When 2 horses were dosed with cultures of a Fusarium moniliforme isolate that had
      previously caused only hepatosis, 1 developed brain oedema and hepatosis, and the
      other only leukoencephalomalacia. A 3rd horse developed both
      leukoencephalomalacia and hepatosis after being dosed with another isolate
      obtained from maize which was associated with a natural outbreak of the nervous
      form of the disease. Since leukoencephalomalacia and hepatosis could be induced
      by the same culture material, it was concluded that both syndromes were
      manifestations of the same toxicosis. There was also some evidence that
      leukoencephalomalacia might be specifically induced by the administration of
      smaller doses of the culture material to horses over a longer period. The
      clinical signs of nervous disorder included ataxia, paresis, apathy,
      hypersensitivity, frenzy, and other locomotory and psychic disturbances. Autopsy
      showed that the brains were oedematous, and focal areas of liquefactive necrosis
      were present in the cerebral white matter. In 1 case the malacic areas were not
      confined to the subcortical white matter but were microscopically visible in the
      cerebral cortex as well. An histopathological examination of the areas bordering
      on the malacic areas revealed rarefication of the white matter, perivascular
      haemorrhages, oedema and cellular infiltration composed mainly of plasma cells
      and eosinophiles. Many of the macrophages in these areas contained lipfuscin-like
      granules, but these granules also occurred extracellularly in the neuropil. In
      the layers of the cortex nearest the malacic areas, satellitosis and neurophagia
      were commonly seen.

PMID- 1012651
TI  - Light and electron microscopic observations on the development of small
      merozoites of Babesia bovis in Boophilus microplus larvae.
AB  - The development of small pyriform merozoites of B. bovis in the granule-secreting
      cells of the salivary glands of B. microplus larvae, studied with a light
      microscope, showed a close resemblance to that of B. argentina described by Riek
      (1966) in the same tick vector. Dvelopment took place through a process of
      schizogony and resulted in the formation of many merozoites. A study of the
      ultrastructure of developing merozoites in the schizont revealed the following: a
      poorly defined outer membrane; a granular osmiophilic inner membrane; anterior
      and posterior polar rings; rhoptries; micronemes; microtubules; a nucleus;
      spherical bodies of varying size. The schizonts were membrane-bound but no
      parasitophorous vacuoles were seen.

PMID- 1012652
TI  - Q fever in cattle and sheep in Southern Africa. A preliminary report.
AB  - In the course of a study initiated to elucidate the role of known abortifacient
      in ruminants in Southern Africa, Coxiella burnetti was identified in smears
      prepared from bovine and ovine placental tissues obtained from 12 farms. The
      organism was also isolated in embryonated eggs, and specific antibodies were
      demonstrated in sera of animals originating from these farms. In 7 of the 12
      herds in which Q fever was diagnosed, other pathogens were identified
      concomitantly.

PMID- 1012653
TI  - Fertilization capacity of Boophilus decoloratus (Koch, 1844) (Acarina: Ixodidae).
AB  - Thirty individual Boophilus decoloratus (Koch, 1844) males were studied daily,
      some during the whole observation period of 37 days. Newly moulted males spent a
      mean of 3, 8 days (range 3-6 on the host before mating. Males mated with between
      1-8 females (mean 4, 6), spending 2, 6 days (range 1-10) with each and 0, 5 days
      (range 0-4) in between females. The time spent by adult males on the host was
      from 9-37 days. The ability for males to produce viable offspring remained fairly
      constant with each successive female fertilized. Development took place in eggs
      produced by unfertilized female ticks but only a very small percentage (mean
      0,008%) of these eggs hatched.

PMID- 1012655
TI  - Gonad development and gametogenesis in Boophilus decoloratus (Koch, 1844)
      (Acarina Metastriata Ixodidae).
AB  - Phases in the growth of the reproductive organs and gametogenesis were followed
      in both males and females of Boophilus decoloratus (Koch, 1844). Special
      attention was given to the timing of meiosis, the production of mature
      spermiophores, mating and spermiophore relocation in the female. The main growth
      phase of the male testes takes place during the nymphal stage while that of the
      accessory gland complex takes place during the 4 days after moulting and before
      mating. The main growth phase of female ovaries and oviducts takes place during
      the post-mating period on the host and the previposition period. Meiosis in males
      takes place only after the attachment of the newly-moulted ticks; spematogenesis
      and spermiogenesis occur within a period of 4 days, after which pairing and
      spermatophore transfer take place. Meiosis was not observed in female ticks and
      it is concluded that this reduction division takes place only after spermiophore
      penetration of the oocytes and egg shell formation. Female ticks may be
      impregnated more than once, a maximum of 5 matings being deduced from counts of
      spermiophore capsules in the female seminal receptacle. Each spermatophore
      produced by male ticks yields either 1 but more commonly 2 spermiophore capsules.
      The reproduction of B. decoloratus is briefly discussed and compared with other
      Ixodoidea.

PMID- 1012654
TI  - A highly fatal tremorgenic mycotoxicosis of cattle caused by Aspergillus
      clavatus.
AB  - During February 1975, a tremorgenic neurotoxicosis decimated a herd of cattle in
      the northern Transvaal. This hitherto unidentified disease was characterized by
      hypersensitivity, incoordination, a peculiar stiff-legged gait of the hind legs,
      severe generalized tumors of the sketetal muscles, progressive paresis, paralysis
      and constipation. The most notable gross pathological lesions were degenerative
      and necrotic changes in certain skeletal muscles, haemorrhages on the serosal
      surfaces, especially on the dorsal aspect of the rumen, and gastro-intestinal
      stasis. Microscopical examination of the central nervous system revealed
      cytopathological changes consisting of degeneration and necrosis of the large
      motor cells in the ventral horns of the spinal cord and bigger neurones in
      numerous nuclei of the medulla oblongata, midbrain and thalamus. By feeding the
      suspect ration and its component parts to cattle and sheep, it was possible to
      identify mouldy sorghum beer residue as the toxic component in the ration. A.
      clavatus, the dominant fungus on the toxic residue, was readily isolated in pure
      culture. The entire syndrome was then reproduced in a yearling Friesland steer
      dosed with pure cultures of the A. clavatus isolate grown on autoclaved non-toxic
      sorghum beer residue. The toxic principle is not known, but it does not appear to
      be patulin, tryptoquivalone, tryptoquivaline, or any other known tremorgen.

PMID- 1012656
TI  - [Use of thyrocalcitonin in the treatment of fractures].

PMID- 1012657
TI  - [Treatment of multiple and combined injuries of the musculo-skeletal apparatus].

PMID- 1012658
TI  - [Debridement as a reconstructive operation in open injuries of the hand and
      fingers].

PMID- 1012659
TI  - [Treatment of inveterate intraarticular injuries of the ankle joint].

PMID- 1012660
TI  - [Use of long-term intraosseous anesthesia].

PMID- 1012662
TI  - [Study of the dynamics of oxygen tension in the bone regenerate in fractures of
      long tubular bones].

PMID- 1012661
TI  - [Ketalar anesthesia in surgical interventions on the limbs].

PMID- 1012663
TI  - [Tenovaginitis of the fingers caused by overstrain].

PMID- 1012664
TI  - [Comparative evaluation of different methods of osteosynthesis in the treatment
      of diaphyseal fractures of long tubular bones].

PMID- 1012665
TI  - [Surgical tactics in bilateral fractures of the clavicle].

PMID- 1012666
TI  - [Analysis of mistakes and failures in the treatment of fresh fractures of the
      distal end of the crural bones].

PMID- 1012667
TI  - [Diafixation in fractures of the crural bones].

PMID- 1012668
TI  - [Treatment of fractures of the distal third of the femur].

PMID- 1012669
TI  - [Case of extensive avulsion of the scalp].

PMID- 1012670
TI  - [Multiple injuries of the organs of locomotion].

PMID- 1012671
TI  - [Acute post-traumatic gastrointestinal hemorrhage].

PMID- 1012672
TI  - [Excessive calcification of cartilages of the first pair of ribs].

PMID- 1012673
TI  - [Simultaneous closed reposition of the crural bones after fractures by vertical
      skeletal traction].

PMID- 1012675
TI  - [Apparatus for the reposition and fixation of bone fragments].

PMID- 1012674
TI  - [Device for surgical treatment of fractures of the crural bones].

PMID- 1012676
TI  - [Universal conductor for pins and drills].

PMID- 1012677
TI  - [Stand for blood transfusion equipment and anesthesiological table].

PMID- 1012678
TI  - [Analysis of industrial traumatism in the coal mines and its prognosis].

PMID- 1012679
TI  - [Remote results of treatment of multiple rib fractures].

PMID- 1012680
TI  - [Rational clinical classification of hand injuries].

PMID- 1012681
TI  - [Conditions determining hip joint development after conservative treatment of
      congenital dislocation of the hip].

PMID- 1012682
TI  - [Dynamics of hip joint development following surgical treatment of congenital
      subluxation of the hip in children].

PMID- 1012683
TI  - [Rehabilitation following closed reduction of congenital dislocation of the hip
      in children over the age of 1 year].

PMID- 1012684
TI  - [Rehabilitation of children with congenital dislocation of the hip following
      surgery on the hip joint].

PMID- 1012686
TI  - [Diagnosis and treatment of congenital dislocation of the hip in newborns].

PMID- 1012685
TI  - [Treatment of congenital dislocation of the hip under rural conditions].

PMID- 1012687
TI  - [Inheritance of excessive joint mobility in congenital dislocation of the hip].

PMID- 1012688
TI  - [Surgical correction of varus and valgus deformities of the elbow joint in
      children].

PMID- 1012689
TI  - [Clinical picture, diagnosis and genetic aspects of hypochondroplasia].

PMID- 1012690
TI  - [Distraction epiphyseolysis for congenital shortness of a lower extremity].

PMID- 1012691
TI  - [Clinico-anatomic features of providing prostheses for women with femoral
      stumps].

PMID- 1012692
TI  - [Clavicle deformities following high amputations of the humerus in children].

PMID- 1012693
TI  - [Treatment of combined injuries to the pelvic bones].

PMID- 1012694
TI  - [X-ray measurement of the angles of the proximal region of the femur and the
      angle of the frontal inclination of the acetabulum].

PMID- 1012695
TI  - [Contrast electroroentgeriography in congenital dislocation of the hip].

PMID- 1012696
TI  - [Assessment of Chiari's osteotomy and its modification in children with
      congenital dislocation of the hip].

PMID- 1012697
TI  - [Subtrochanteric osteotomy of the hip with creation of a double "catch" in
      treatment of congenital dislocation of the hip].

PMID- 1012698
TI  - [Prognosis of the development of the hip joint following conservative reduction
      of congenital dislocation of the hip].

PMID- 1012699
TI  - [Skeletal traction for fractures of the phalanges of the fingers].

PMID- 1012700
TI  - [Method of surgical treatment of patients with fractures of the olecranon].

PMID- 1012701
TI  - [Epicutaneous fixation of an arterial catheter for prolonged intra-arterial
      infusion of solutions].

PMID- 1012702
TI  - [Elongation of segments of the extremities with simultaneous increase in their
      volume].

PMID- 1012703
TI  - [Formation of the transverse arch of the foot].

PMID- 1012704
TI  - [Results of the 9th five-year-plan and prospects for the growth of traumatology
      and orthopedics in the Ukrainian SSR].

PMID- 1012705
TI  - [Organization of early detection of dysplasia of the hip joint and muscular
      torticollis in children].

PMID- 1012706
TI  - Theoretical interstellar and prebiotic organic chemistry: a tentative
      methodology.
AB  - A theoretical methodology for the systematic study of the interstellar molecules
      is proposed. Some examples, dealing with formaldehyde excited states, formyl
      radical and ion, reactivity of the excited states of formic acid, methyl cyanide
      and methyl acetylene, as well as the reaction patho of formaldehyde
      photodecomposition are presented. Quantum chemical methods appear to be a
      powerful tool to study the structure and behaviour of molecules related with
      interstellar space and the Origin of Life.

PMID- 1012707
TI  - Vulcanism, mercury-sensitized photo-reactions and abiogenetic synthesis: a
      theoretical treatment.
AB  - Attention is called to the photodynamic and thermodynamic properties of Periodic
      Group IIb elements, most notably Hg, as they relate to ultra-violet sensitization
      in organic chemical reactions. The energy levels of 6(1) P1 and 6(3) P1 resonance
      states and the high vapor pressure ((greater than 10(-3) mm) of the metal at
      temperatures as low as 293 K bring Hg with the range of bond dissociation
      energies in most organic molecules and many inorganics. These capabilities
      considered together with recent evidence for Hg emission as a regular part of
      volcanic and geothermal processes provide the basis for our proposal that Hg
      sensitized ultraviolet photo-reactions may have played a significant part in
      abiogenetic organic synthesis on the primative earth.

PMID- 1012708
TI  - Glycine and alanine synthesis from formaldehyde and hydroxylamine in the field of
      ultrasound waves.
AB  - High intensity ultrasound waves coupled with other form of energy obviously were
      initiators of pre-biochemical reactions; these reactions occurred in the water
      masses of the primordial Earth. Essential biological substances like
      formaldehyde, ammonia, hydrocyanic acid, and amino acids compounds similar to
      carbohydrates by their properties were synthesized in the field of ultrasound
      waves in model experiments. The main partners of these reactions are water and
      gases of reductional atomosphere: hydrogen, carbon monoxide, methane, nitrogen
      and argon. Formation of amino acids takes place in aqueous solutions of
      formaldehyde and hydroxylamine. The sonication yielded alanine and glycine, 2.0 X
      10(-7) and 1.8 X 10(-7) molecules per 100 eV respectively.

PMID- 1012709
TI  - Formation of biologically relevant carboxylic acids during the gamma irradiation
      of acetic acid.
AB  - Irradiation of aqueous solutions of acetic acid with gamma rays produced several
      carboxylic acids in small yield. Their identification was based on the technique
      of gas chromatography combined with mass spectrometry. Some of these acids are
      Krebs Cycle intermediates. Their simultaneous formation in experiments simulating
      the primitive conditions on the earth suggests that metabolic pathways may have
      their origin in prebiotic chemical processes.

PMID- 1012711
TI  - A cybernetic approach to the origin of the genetic coding mechanism. I.
      Methodological principles.
AB  - It is postulated that some quasi-deterministic code features (universality,
      connectedness, systematic degeneracy, symmetry, regularity and so on) resulted
      from unique (and therefore universal) relization of a stochastic evolutionary
      process. The evolution of real genetic systems should satisfy the principle of
      succession; that is, loss of a feature that is necessary for a genetic system
      means death to its carrier. The hypothesis of unique key coincidence is proposed
      which indicates the mechanisms of arising of the primary correspondence between
      the linear structures of polynucleotides and polypeptides. If the collinear
      coincidence was to appear in the key positions of pra-protein with, at least,
      some of the primitive properties of the pra-amino-acyl-t-RNA-synthetase required
      for the accelerated recognition of the key positions of pra-template, the
      positive feed-back mechanism in the system would be most short-circuited so that
      the repetitive reproduction of pra-synthetase would be much accelerated.

PMID- 1012710
TI  - Prebiotic condensation reactions in an aqueous medium: a review of condensing
      agents.
AB  - Biopolymers are formed by dehydration-type condensation reactions. In aqueous
      solutions dehydration reactions are very unlikely to happen spontaneously.
      However, coupling of dehydration-condensation to the hydrolysis of condensing
      agents could facilitate the synthesis of biopolymers in an aqueous solution. The
      literature shows that the peptides, nucleosides, nucleotides and oligonucleotides
      can be formed in this way. A careful study of the literature pertaining to
      prebiotic condensing agents was conducted in order to determine the most
      plausible prebiotic synthesis of biopolymers. The condensing agents taken into
      consideration are cyanamide, carbodimide, dicyanamide, dicyandiamide, hydrogen
      cyanide-tetramer, cyanogen and the linear- and cyclic polyphosphates. From both a
      chemical as well as biological point of view the polyphosphates appear to be the
      most plausible general prebiotic condensing agent.

PMID- 1012712
TI  - A cybernetic approach to the origin of the genetic coding mechanism. II.
      Formation of the code series.
AB  - The sequential fulfillment of the principle of succession necessarily guides the
      main steps of the genetic code evolution to be reflected in its structure. The
      general scheme of the code series formation is proposed basing on the idea of
      "group coding" (Woese, 1970). The genetic code supposedly evolved by means of
      successive divergence of pra-ARS's loci, accompanied by increasing specification
      of recognition capacity of amino acids and triplets. The sense of codons had not
      been changed on any step of stochastic code evolution. The formulated rules for
      code series formation produce a code version, similar to the contemporary one.
      Based on these rules the scheme of pra-ARS's divergence is proposed resulting in
      the grouping of amino acids by their polarity and size. Later steps in the
      evolution of the genetic code were probably based on more detailed features of
      the amino acids (for example, on their functional similarities like their
      interchangeabilities in isofunctional proteins).

PMID- 1012713
TI  - The palirrhotrophic origin of energy metabolism.
AB  - It is proposed that the earliest cellular organisms relied upon a novel type of
      energy transduction termed palirrhotrophy, which generates a high-energy
      "currency" chemiosmotically by exploiting the rhythmic variations in salinity
      which occur in the estuarine environment. Calculations based on estimates of
      contemporary chemiosmotic transduction efficiency suggest that such a mechanism
      could produce usable energy in high yield. The minimum polypeptide requirement
      for palirrhotrophy compares favorably with that of a fermentative pathway. It is
      suggested that palirrhotrophic organisms exist today but are difficult to detect.

PMID- 1012714
TI  - Hydrocarbons obtained by pyrolysis of some precambrian rocks of Minnesota.

PMID- 1012715
TI  - On the significance of tetrahedral tetrads of Precambrian algal cells.

PMID- 1012716
TI  - The origin and evolution of the Viking mission to Mars.

PMID- 1012717
TI  - General constraints on the Viking biology investigation.
AB  - The Viking biological investigation will be conducted in the face of a number of
      constraints. Problems are created because of the inherent engineering of the
      instrument, communication constraints and other factors.

PMID- 1012718
TI  - The pyrolytic release experiment: measurement of carbon assimilation.

PMID- 1012719
TI  - Labeled release - an experiment in radiorespirometry.

PMID- 1012720
TI  - The search for life on Mars: Viking 1976 gas changes as indicators of biological
      activity.

PMID- 1012721
TI  - [Resorption of saccharose and fructose in relation to age. Biokinetic studies on
      rabbits].

PMID- 1012722
TI  - [Value and usefulness of lung function tests in children].

PMID- 1012723
TI  - [Treatment with anapolon of juvenile aplastic anemia].

PMID- 1012725
TI  - Percentiles for height and weight of children between 6-12 years of age in
      Bandung.

PMID- 1012724
TI  - Adoption at Dr. Kariadi Hospital Semarang.

PMID- 1012726
TI  - Cerebral palsy in Y.P.A.C. (Institution for Crippled Children) Semarang.

PMID- 1012727
TI  - Tetanus neonatorum in the Bethesda Hospital Yogyakarta.

PMID- 1012728
TI  - Neonatal tetanus. Evaluation of treatment and a proposal for classification of
      severity.

PMID- 1012729
TI  - Progressive muscular dystrophy (Duchenne type) (case report).

PMID- 1012730
TI  - Positive tuberculin and primary tuberculosis. Frequency among non-BCG children of
      0-4 years. (preliminary report).

PMID- 1012731
TI  - Caries in outpatients at the Department of Child Health and Dental Clinic of the
      Provincial Referral Hospital (RSUPP) in Medan during 1971-1973.

PMID- 1012733
TI  - Congenital adrenal hyperplasia. (case report).

PMID- 1012732
TI  - Retroperitoneal teratoma in an eleven-month-old baby. (case report).

PMID- 1012734
TI  - The use of anthelmintics in the treatment of ascariasis.

PMID- 1012735
TI  - Treatment of bronchopneumonia with spiramycine (Rovamycine).

PMID- 1012736
TI  - Tiberal (Ro 7-0207-Roche) in the treatment of intestinal amoebiasis--Part II.

PMID- 1012737
TI  - Flagyl (Metronidazole) in the treatment of intestinal amebiasis. Part IV.

PMID- 1012738
TI  - [Cutaneous cholesterol and phospholipids in atherosclerosis].
AB  - Previously, a lesion parallelism between skin and vascular wall was established
      when aging. Besides, we have pointed out a significant increase of cutaneous
      sterols rate along with aortic atheromatous stage. This study brings forward a
      new fact: increase (not significant because wanting much more examples) of
      cutaneous squalene rate varying with atheroma intensity, but reversely stability
      of total phospholipids with their various fractions.

PMID- 1012739
TI  - Transport of lipoprotein lipase in the endothelium of rat heart.

PMID- 1012740
TI  - Early detection of lipoprotein abnormalities in children.

PMID- 1012741
TI  - [Incorporation of labeled precursors in glycosaminoglycans of the media-intima of
      the arterial wall].
AB  - The enzymes involved in glycosaminoglycans biosynthesis are characterized in
      homogenates of aortic media-intima. Incorporation of hexosamine from uridine
      nucleotide precursor was done into the saccharide chains of glycosaminoglycans.
      Labelling of aortic glycosaminoglycans by 35S-precursors is performed in our
      fractions; the results obtained demonstrate the uptake of 35S-sulfate from its
      corresponding active nucleotide sulfate ; highest sulfation is obtained for the
      post-microsomal supernatant. Following incorporation of 35S-sulfate or 14C-radio
      activity into the different glycosaminoglycans, the largest percent uptake is
      obtained for heparan sulfate and the lowest for chondroitin sulfate.

PMID- 1012742
TI  - [Incorporation of 32P-orthophosphate in aortic phospholipids in chronic lathyrims
      in the rat].
AB  - Study of 32P orthophosphate incorporation into rat aortic phospholipids after
      B.A.P.N. treatment, which was followed or not by a lipid-supplemented diet (4.5
      p. 100 cholesterol and 37 p. 100 butter). The 32P orthophosphate turnover in the
      total phospholipid was twice as slow among B.A.P.N.-treated rat than among
      control-rat. Such a decrease of the 32P orthophosphate turnover could be found as
      well in phosphatidylethanolamines, phosphatidylcholines and
      lysophosphatidylcholines. Sphingomyelins showed a very weak metabolic activity
      among two groups of rats. 32P orthophosphate incorporation into
      inositolphosphatides was slowed down by B.A.P.N. treatment. Maximal specific
      activity of inositolphosphatides after injection of 32P orthophosphate was
      reached within 4 hours in control rats, and 8 hours in B.A.P.N.-treated rats.
      Three months after the end of B.A.P.N. treatment, no difference in specific
      activity could be found between control-rats and B.A.P.N.-treated rats. Lipid
      supplemented diet modified the metabolic activity of phospholipids equally in
      control rats and B.A.P.N.-treated rats. Specific activity decrease in total
      phospholipids, phosphatidylcholines, phosphatidylethanolamines, and increase in
      lysophosphatidylcholines were noted in both groups of animals under a high rat
      diet. These modifications of the metabolic activity of different phospholipids
      were most marked fourteen hours after 32P orthophosphate injection. B.A.P.N.
      treatment only slowed the incorporation of 32P phosphate into phospholipids.
      Administration of a single lipid supplemented diet or a diet associated with
      B.A.P.N. treatment induced a slower turnover of phosphatidylcholines and
      phosphatidylethanolamines, and a faster turnover of lysophosphatidylcholines.

PMID- 1012743
TI  - Luminal eccentricity and deformity in atherosclerotic coronary arteries.
AB  - Detailed analyses of the configuration of lumina from one hundred (100) segments
      of severely atherosclerotic epicardial coronary arteries (at least 75 p. 100 of
      the area of their original lumina narrowed, determined by planimetry) were made.
      All lumina were distended by a standardized coronary injection technique. In
      contrast to the general impression, concentric lumina occurred as commonly as
      eccentric lumina and there were more arteries with an eccentric lumen and/or with
      significant luminal deformity, i.e. with their smallest diameter smaller than 50
      p. 100 of their greatest diameter, than the concentric and more regular ones. The
      eccentricity and significant deformity of atherosclerotic lumina apparently cause
      difficulties in precise angiographic measurements of coronary stenosis. To solve
      the problem of the discrepancies between angiographic and anatomical estimation
      of coronary arterial stenosis, utilization of more than three different
      projection angles should be considered in clinical angiographic appraisal.

PMID- 1012744
TI  - Schistosoma mansoni in the baboon (Papio anubis): parasitological responses of
      Kenyan baboons to different exposures of a local parasite strain.
AB  - The course of infection with a local strain of Schistosoma mansoni was
      investigated in Kenyan baboons (Papio anubis). A single exposure to 5000
      cercariae per baboon (cpb) killed five 4-8 kg baboons; a sixth survived the full
      30-week post-exposure period, with suppressed egg production after week 11. Lower
      doses were not lethal. A single exposure to 1000 cpb gave satisfactory adult worm
      recoveries, high and steady faecal egg excretion, and a high tissue egg recovery,
      predominantly from the large intestine. A similar but less consistent picture was
      obtained with a single exposure to 200 cpb. Baboons receiving 5 monthly exposures
      of 200 cpb (1000 cpb total) showed some evidence of the development of protective
      immunity. Three animals showed patterns resembling those for 200 and 1000 cpb.
      The other 3 had suppressed egg production (faecal and tissue) indicating,
      perhaps, some immunological process. They also had an abnormally high percentage
      of eggs in the liver.

PMID- 1012745
TI  - Studies on the hatchability of Schistosoma mansoni eggs from a naturally infected
      human community on St Lucia, West Indies.
AB  - A relatively simple, standardized hatching test was devised, tested and used to
      estimate the Schistosoma mansoni hatching rate for 88 St Lucian subjects selected
      by age, sex and intensity of infection. The hatching rate was dependent on the
      intensity of infection and rose proportionately with it. The rate also decreased
      with increasing age of the subject. Sex alone had no direct effect but there was
      a suggestion of an interaction between sex and age. These results suggest that
      several hatching tests are necessary, before and after treatment in
      schistosomicidal drug trials, to permit valid conclusions to be drawn. The
      hatching data are used in conjunction with survey results to calculate the
      contamination potential of different age groups in a population. School children
      (5-14 years old) are about twice as important as young adults (15-29 years old)
      who, nevertheless, contribute over a quarter of the total contamination
      potential. However, whereas school children are fairly accessible for mass
      chemotherapy control programmes, young adults often are not and, furthermore,
      involve problems associated with the treatment of women of child-bearing age.

PMID- 1012746
TI  - Eimeria tenella: experimental studies on the development of resistance to
      robenidine.
AB  - The development of resistance by the Houghton strain (H) of E. tenella to
      robenidine has been studied in the laboratory, by serially passaging the strain
      in chickens fed increasing concentrations of drug. Resistance to robenidine
      developed more readily in experiments using larger numbers of birds with higher
      numbers of oocysts in the inoculum. Both these factors increased the parasite
      population and increased the chance of selecting parasites resistant to the drug.
      E. tenella (H) was made resistant to 264 ppm robenidine and showed no cross
      resistance to other anticoccidial agents. Resistance arose in a series of 'steps'
      as the concentration of drug was increased. E. tenella (H) was continuously
      passaged at concentrations ranging from 2 to 33 ppm of robenidine. After 16
      passages, lines passaged at 2,4 and 8 ppm were not resistant to 33 ppm
      robenidine, suggesting that the degree of resistance developed was dependent upon
      the drug selection pressure.

PMID- 1012747
TI  - Further studies on the use of chicken embryo infections for the study of drug
      resistance in Eimeria tenella.
AB  - Infections in the chicken embryo have been used to study the development of drug
      resistance in an embryo adapted strain of E. tenella. Resistance was developed to
      decoquinate, clopidol and robenidine by serially passaging this strain, but
      evidence for the development of resistance to amprolium was inconclusive.
      Resistance to decoquinate developed more readily than to the other drugs.
      Attempts to increase resistance to clopidol, robenidine and amprolium by
      increasing the sporozoite inoculum and by the use of a mutagenic agent were
      unsuccesful. No cross-resistance was found between the 4 drugs. Drug resistant
      lines of the Houghton strain (H) of E. tenella, made resistant to the 4
      anticoccidial drugs by passage in chickens, were found to be resistant when
      evaluated using chicken embryo infections. Lines made resistant to decoquinate
      were not controlled by any concentration of this drug, suggesting that
      resistance, once developed, was absolute and not dependent on drug concentration.
      Lines made resistant to robenidine, clopidol and amprolium, however, were
      controlled by higher drug concentrations suggesting that in this case resistance
      was dependent on drug concentration.

PMID- 1012748
TI  - Laboratory studies with some older anticoccidials.
AB  - Features of the anticoccidial activity of nicarbazin, amprolium, zoalene,
      sulphadimidine, diaveridine, Darvisul, spiramycin, chloramphenicol and
      oxytetracycline have been re-investigated both in vivo and in cell culture using
      Eimeria tenella. Of the drugs studied, only spiramycin was appreciably
      coccidiocidal, although nicarbazin and amprolium showed possibly slower
      coccidiocidal activity. In order to show activity against a particular stage in
      the life-cycle, higher concentrations of drug than those usually recommended for
      field usage had in most cases to be used. Under these conditions, parasites were
      usually inhibited as multinucleate 1st generation schizonts. With delayed
      medication, effects against 2nd generation parasites were in most cases found,
      and in many cases, although the parasites never matured to give viable
      merozoites, the large degenerating forms produced were able to cause extensive
      tissue destruction and haemorrhage. Methodology in this type of study is
      discussed in relation to more active and more recent anticoccidials, and some
      further experiments with robenidine reported.

PMID- 1012749
TI  - Studies on site finding and site specificity of Eimeria praecox, Eimeria maxima
      and Eimeria acervulina in chickens.
AB  - Sporozoites of 3 species of Eimeria were introduced into the caecum of young
      chickens. E. praecox and E. maxima failed to develop in this site, but light
      infections of E. acervulina were detected. Infection of the small intestine with
      all 3 species occurred when sporozoites were introduced via the caecum.
      Infections were produced when mucosal scrapings of small intestine from birds,
      inoculated via the caecum 1-4 h previously, were inoculated orally to susceptible
      chickens. Experiments with 51Cr-labelled sporozoites of E. praecox introduced in
      the caecum, confirmed that small numbers of sporozoites are capable of migrating
      from the lower to the upper intestine. Sporozoites were not transferred with
      liver tissue from birds given sporozoites via the caecum but were transferred
      with the liver of chickens given sporozoites intraperitoneally.

PMID- 1012751
TI  - The effect of moisture supply upon the development and hatching the eggs of
      Nematodirus battus.
AB  - Experiments were carried out to investigate the effect of variations in humidity
      and osmotic pressure upon the development and hatching of the eggs of Nematodirus
      battus. It was found that no development or hatching took place unless there was
      free water available, though humidity effects could enhance the subsequent
      response of the eggs in water. Larvae were found to be very resistant to
      prolonged exposure to low humidity. The concentration of the hatching medium
      showed little effect upon development of eggs, though the rate of larval
      emergence was reduced as the concentration of the culture medium increased. The
      relevance of this information is discussed in the context of other requirements
      of the egg stages during their hatching phase and how this may affect the
      behaviour of this nematode under field conditions.

PMID- 1012750
TI  - Some observations on the sexual differentiation of Eimeria tenella using single
      sporozoite infections in chicken embryos.
AB  - Unsporulated oocysts were recovered from the allantoic cavity of 5 chicken
      embryos inoculated with a single sporozoite of Eimeria tenella; some of these
      oocysts sporulated. Both macrogametes and microgametes are required for the
      formation of viable oocysts. The results conclusively demonstrate the bisexual
      nature of the sporozoite, suggest that sexual differentiation is influenced by
      environmental factors, and show that true clones of Eimeria can be established
      from individual sporozoites.

PMID- 1012752
TI  - Seasonal abundance of Neoechinorhynchus cylindratus taken from largemouth bass
      (Micropterus salmoides) in a heated reservoir.
AB  - Samples of largemouth bass were collected from Par Pond located on the Energy
      Research and Development Administration's Savannah River Plant in Aiken, South
      Carolina, from June 1972 to May 1973 inclusive. The sampling stations reflected
      water temperatures which were both normal and greater than 10 degrees C above
      normal for the area. The acanthocephalan Neoechinorhynchus cylindratus was the
      dominant species found in the bass sampled. Incidences of infection for this
      parasite were generally greater than 95% regardless of location. A pronounced
      seasonal cycling pattern in the intensity of infection was noted in both thermal
      regions. Significant differences, however, in the mean density of N. cylindratus
      per host in fish taken from the heated area as compared with unheated areas were
      noted. Turnover in the acanthocephalan population was measured by following the
      percentage of individuals less than 2 mm long. Fall proved to be the most intense
      parasite recruitment season, followed by maturation of parasite and subsequent
      loss from the fish host. The principal factors responsible for the seasonal
      incidence and intensity patterns are considered to be changes in the fish feeding
      behaviour and annual temperature regimes.

PMID- 1012753
TI  - Parasitic helminths of the American avocet Recurvirostra americana: four new
      species of the families Hymenolepididae and Acoleidae (Cestoda: Cyclophyllidae).
AB  - Records are presented of 11 species of parasitic helminths recovered from 37
      American avocets. Birds were collected in Kansas and Colorado from April 1973 to
      August 1974. Parsites found included 3 trematodes, 2 nematodes, 1 acanthocephalan
      and 5 cestodes, 4 of which are new species. Hymenolepis cervotestis sp.n.
      (Hymenolepididae) is described from the small intestine of 7 avocets. It exhibits
      extreme protandry with the testes appearing before external segmentation is
      evident. Sobolevicanthus coloradensis sp.n. (Hymenolepididae) is described from
      the small intestine of 4 avocets. This species is found to have its scolex
      embedded in the intesttinal mucosa of its host. Diorchis recurvirostrae sp.n.
      (Hymenolepididae) is described from specimens recovered from the small intestine
      of 5 avocets. Diplophallus coili sp.n. (Acoleidae) is described from the small
      intestine of all 37 avocets. The family Diploposthidae is suppressed and the
      family Acoleidae is emended to include the 4 genera previously placed in
      Diploposthidae. A key to the genera of Acoleidae is presented.

PMID- 1012754
TI  - Dynamic determinants of the route of larval Strongyloides ratti in lactating rats
      and the control of experimental error in quantitative studies of milk
      transmission of skin-penetrating roundworms.
AB  - Subcutaneous injection of nursing mothers from day 16 to day 20 post partum with
      infective larvae of Strongyloides ratti or Nippostrongylus brasiliensis does not
      result in the development of worms in the litters if 1 h is allowed between
      injection and resumed nursing and suckling is terminated 24 h later. Thus the low
      numbers of N. brasiliensis (1% of the dose) which develop in litters after 24 h,
      4 day or 5 days suckling when mothers are injected and returned  to their young
      immediately, represent skin invasion and not milk-borne infection. Taking
      precautions consistent with the foregoing, S. ratti equivalent to 28%, 45%, 45%
      and 48% of the dose were shown to be transmitted in the milk to suckling rats of
      4 mothers injected with 4000 L 3 on day 18 post partum and 72 h before weaning.
      One mother of the same batch failed to transmit worms (1% of the dose in the
      litter) and the take in all 5 mothers was insignificant (max. = 3% of the dose
      versus an average of 21% in controls). Large numbers of S. ratti were
      subsequently found in the intestines of mothers whose litters were weaned
      immediately after (21%) or 6 h after (16%) injection, whereas very few (less than
      1%) developed in mothers deprived of their offspring 24 h after injection.
      Dynamic, rather than static, determinants of larval routes inside the host
      present the only logical basis for an explanation of these facts.

PMID- 1012755
TI  - Echinococcus granulosus: development in vitro from oncosphere to immature hydatid
      cyst.
AB  - Echinococcus granulosus cysts were cultured in vitro from the oncosphere, and
      cyst morphogenesis is described. Cysts grew to a mean diameter of 16 mm in 120
      days, with a maximum of 20 mm. An amorphous layer was apparent around the larvae
      during early post-oncospheral re-organization. Organisms became vesicular at 6
      days and laminations appeared in the amorphous layer at 10 days. Confluence of
      proliferating cells to form the syncytium of the germinal membrane was observed.

PMID- 1012756
TI  - [Cholinergic system and resistance of the body to experimental cranio-cerebral
      injury].

PMID- 1012757
TI  - [State of biological oxidation processes in the bodies of animals during
      inflammation].

PMID- 1012758
TI  - [Effect of an extract of embryonal liver on indices of adrenal cortex
      glycocorticoid function in rats].

PMID- 1012759
TI  - [Specificity of the pathogenic effect of gas gangrene toxins on spinal alpha
      motoneurons of cats].

PMID- 1012760
TI  - [Changes in the electrocardiogram of rats following injury and stimulation of
      regeneration of the myocardium].

PMID- 1012761
TI  - [Biological activity of the intrinsic factor in acute blood loss].

PMID- 1012762
TI  - [Immunologic status and frequency of leukemia in mouse strains AKR and CC57BR
      following chronic immunization with ADPT vaccine].

PMID- 1012763
TI  - [Lipid metabolism in the mitochondrial fractions of the brains of dogs with
      allergic encephalomyelitis].

PMID- 1012764
TI  - [Effect of the thermal factor on the activity of different enzymes of the small
      intestinal mucosa].

PMID- 1012765
TI  - [Amino acid biosynthesis in the healthy and perinecrotic zone of the cardiac
      muscle in the acute period of experimental myocardial infarct].

PMID- 1012767
TI  - [Anaerobic glycolysis in severe blood loss].

PMID- 1012766
TI  - [Change in the state of the lysosomal apparatus of liver cells in rats with
      severe burns].

PMID- 1012768
TI  - [Effect of vitamin K on proconvertin metabolism in thyrotoxicosis].

PMID- 1012770
TI  - [Morphologic reflection of the character of cell structure functioning (regarding
      the article by G.N. Kryzhanovskii, "Several basic patterns in the realization of
      biological processes and their role in pathology")].

PMID- 1012769
TI  - [Method of producing different stages of hemic hypoxia in rats by administering
      sodium nitrite].

PMID- 1012771
TI  - [Verification of decision making rules in medical diagnosis].

PMID- 1012772
TI  - [Histochemical and ultrastructural studies of the heart muscle during
      electrically induced fibrillation with and without perfusion of the coronary
      vessels under conditions of moderate hypothermia].

PMID- 1012773
TI  - [Histochemical and ultrastructural changes in the heart muscle of dogs following
      75 minutes of extracorporeal circulation with perfusion of the left coronary
      artery under conditions of moderate hypothermia].

PMID- 1012774
TI  - [Histochemical and ultrastructural changes in the heart muscle of dogs following
      75 minutes of extracorporeal circulation with perfusion of both coronary arteries
      under conditions of moderate hypothermia].

PMID- 1012775
TI  - [Comparative studies of histochemical changes in dog kidney following unilateral
      clamping of the renal artery and vein].

PMID- 1012776
TI  - [Regeneration of mucous membrane in duodenal defects closed with acryl adhesives
      and a loop of the small intestine].

PMID- 1012777
TI  - [Healing of intestinal anastomoses performed with tissue adhesives in
      experimental ileus in rats].

PMID- 1012778
TI  - [Pathomorphology of epulis].

PMID- 1012779
TI  - [Lipoma of the uterine corpus].

PMID- 1012780
TI  - [Congenital embryonic neurinoma of the adrenal glands discovered at autopsy.
      Report of 2 cases].

PMID- 1012781
TI  - [Neurimoma of Meckel's diverticulum undergoing malignant conversion].

PMID- 1012782
TI  - [Thymus hormones: chemical characteristics and biological properties].

PMID- 1012783
TI  - [Histo-radiological correlations in lobular carcinoma of the breast].

PMID- 1012784
TI  - [Anatomo-pathological findings of adrenal glands in sudden death].

PMID- 1012785
TI  - [Various recent biological and anatomo-clinical aspects of tuberculous
      meningitis].

PMID- 1012786
TI  - [Short anatomo-pathological study on a case of succenturiate kidney].

PMID- 1012787
TI  - [Diffuse mesothelioma of the peritoneum and exposure to asbestos. (Reflections on
      2 cases)].

PMID- 1012788
TI  - Persistent pneumatoceles associated with systemic leukocyte abnormalities.
AB  - Three patients with leucocyte related immune deficiency developed pneumatoceles
      during acute bacterial pneumonia. A fourth patient with chronic granulomatous
      disease of childhood developed persistent lung cysts following pulmonary
      abscesses. The pneumatoceles persisted without significant change for one year to
      five years. In 25 immunologically normal patients, pneumatoceles that were
      associated with acute bacterial pneumonia resolved in 3 weeks to 11 months.
      Perhaps alterations in leukocytic function and in local inflammatory response
      result in fibrotic cellular reaction and sequestration of parenchymal air
      collections, precluding their resorption.

PMID- 1012789
TI  - Colonic granulometry in the malabsorption syndromes.
AB  - After transit through the small intestine barium enters the large intestine and
      its characteristics in that gut segment can be studied. The pattern of
      distribution of barium in the colon is always altered in patients with
      malabsorption syndromes. The physical basis for this alteration is analysed in a
      manner analagous to that used in soil mechanics. The dispersal of barium granules
      within the liquid-solid content of the colon is related to certain factors among
      which is the polarisation and electrical potential of barium particles. A
      technique using four radiographs which permits evaluation of barium dispersal in
      the colon - colonic granulometry - is described. Lastly, the authors point out
      the necessity of classical barium studies in identifying the rare anatomical
      anomalies that can be the starting point of a typical clinical coeliac syndrome.

PMID- 1012790
TI  - Pediatric abdominal angiography: practical guide to catheter selection, flow
      rates, and contrast dosage.
AB  - Abdominal angiography is an extremely valuable modality for the diagnosis of
      abdominal disease in infants and children. A practical guide to catheter
      selection, flow rates, and contrast dosage for abdominal angiography in the
      pediatric patient is presented.

PMID- 1012791
TI  - Limb defects in the amniotic band syndrome.
AB  - The clinical and radiological findings seen in three babies born with
      characteristic limb defects are presented. These defects are thought to be due to
      intrauterine amniotic constricting bands rather than an endogenous developmental
      defect in the foetus. The theory of formation of bands is discussed.

PMID- 1012792
TI  - Roentgen findings in fractures of the vertebral column in childhood examination
      of 35 patients and its results.
AB  - In the past 10 years we examined 35 children with fractures of the spine. The
      most important cause was an injury by a fall from a tree or a climbing stage (23
      cases). Traffic accidents or other direct trauma was the cause in 10 patients.
      Two children had tetanus, The ages of the children range from 2 to 12 years.
      Clinical symptoms may be diagnostic of vertebral trauma, but quite often symptoms
      are insignificant or atypical. We detected fractures in every vertebra of the
      thoracic and lumbar part of the spine. The greatest number of fractures was found
      between T4 and L2. The typical injury of the spine is a compression fracture of
      the vertebral body with a wedgeshaped deformity (111 vertebrae); fractures of the
      transverse processus of lumbar vertebrae were not frequent (10 vertebrae). Other
      parts of the vertebrae were not involved. The value of scintigraphy in case of
      doubtful roentgenologic finding is pointed out.

PMID- 1012794
TI  - Perforated appendix presenting with disproportionate jejunal distention.
AB  - Six cases of perforated appendix are presented in whom there was disproportionate
      gas distention of the jejunum without other radiographic signs of appendicitis.
      This appearance tended to divert one's attention from the offending cause in the
      right lower abdomen.

PMID- 1012793
TI  - Drug inducted bone changes in myositis ossificans progressiva.
AB  - Dermineralization and disorganized bone growth may result in children treated
      with diphosphonates.

PMID- 1012795
TI  - Intracranial calcification mimicking the Sturge-Weber syndrome: a consequence of
      cerebral folic acid deficiency?
AB  - Cerebral cortical calcification identical to that of the Sturge-Weber syndrome
      was observed in two children. In one child the calcification appeared after
      intrathecal administration of methotrexate and skull irradiation because of
      leukemia involving the central nervous system. In the other child, who had
      coeliac disease and epilepsy, the calcification appeared after treatment with
      anticonvulsants. This treatment was also contributing to the development of
      profound megaloblastic anemia. The unspecificity of the Sturge-Weber
      calcification is stressed and the hypothesis is put forward that the
      calcification may be secondary to folic acid deficiency interfering with the
      matabolism in the central nervous system.

PMID- 1012796
TI  - Single bone involvement in congenital syphilis.
AB  - A case of congenital lues with single bone involvement is reported. Such a
      presentation of this disease can cause problems in diagnosis. This aspect of the
      case is discussed and the literature on the subject reviewed. The uniqueness of
      this case is emphasized for only two other such cases have been reported in the
      literature.

PMID- 1012797
TI  - Total body opacification and the adrenal.

PMID- 1012798
TI  - Hypophosphatasia. Review of 24 cases.
AB  - Radiographic analysis of 24 cases of hypophosphatasia (H) from 9 Paediatric
      Centres was performed. 3 cases were of neonatal (lethal), 18 cases of infantile
      (severe) and 3 cases of late (benign) type. Some of the patients were in reality
      borderline cases between these groups. In the authors' material all the patients
      showed radiographic signs of the disease. These were divided into diagnostic,
      characteristic and suggestive features. All of the patients had in common
      generalised (usually irregular) osteoporosis, generalised (usually irregular)
      metaphyseal changes, craniostenosis (13 of 18 infantile cases) or widened cranial
      sutures and ofter bowing of the long bones. Besides the well know radiographic
      features of hypophosphatasia some less well known, rare or 'new' ones such as, 1.
      spurs of the long bones (Bowdler sign), 2. distal femoral central metaphyseal
      defects and epiphyseal defects, 3. S-like deformities of the tibiae, 4. abnormal
      shape of the distal phalanges of the fingers, 5. multiple rib fractures and
      slender bones, 6. wedging of the lower thoracic and upper lumbar vertebrae, 7.
      partial premature fusion of the epiphyses, 8. nephrocalcinosis, 9. loss of lamina
      dura around the teeth, 10. variation in radiographic appearances of a pair of
      siblings with lethal form, and, 11. rapid changes in roentgen appearances. are
      discussed. In two of our patients (siblings) phosphoethanolamine was undetectable
      in the urine. The authors doubt if a normal skeletal survey may be present at any
      stage in any of the three major types of hypophosphatasia.

PMID- 1012799
TI  - Mediastinal teratoma confused with loculated pleural fluid.
AB  - A 3-year-old child is presented with a benign anterior mediastinal teratoma that
      was primarily located inferior to the left lung and confused with pleural fluid.
      The lesion was not apparent at 4 months ofage. Computerized axial tomography of
      the specimen clearly established the diagnosis. This procedure may be of value in
      selected patients with apparent pleural disease.

PMID- 1012800
TI  - Long survival in thanatophoric dwarfism.
AB  - A case of thanatophoric dwarfism living for 10 weeks with minimal supportive care
      is presented. Although early death is usual, survival for months is compatible
      with the diagnosis.

PMID- 1012801
TI  - Angiographic assessment of anomalous origin of the left coronary from the
      pulmonary artery in infancy and childhood.
AB  - Angiographic findings in five paediatric patients with anomalous left coronary
      artery arising from the pulmonary artery are presented. An attempt is made to
      provide an angiographic rationale of some aspects of the pathophysiology and
      electrocardiography in this condition, and the vital importance of angiography in
      selecting the appropriate surgical approach is underlined.

PMID- 1012802
TI  - Hodgkin's disease in children: involvement of lung and pleura.
AB  - In 160 children with Hodgkin's disease, lung involvement was studied. In 14.4%,
      lung lesions were diagnosed at the first admission and an additional 7.5% of the
      patients developed lung lesions in the course of the disease. As a rule lung
      involvement was observed in advanced disease. It has been stated that there is no
      particular difference in the response to treatment in any particular type of
      lesion, spread either by contiguity of dissemination. Of all methods of
      treatment, combination chemotherapy (MOPP programme) showed the best results. In
      our series of children it was not possible to show any advantage to favour
      irradiation as against combination chemotherapy in the treatment of lung lesions.

PMID- 1012803
TI  - Choledochal cysts: a clinical and radiological evaluation of 21 cases.
AB  - Choledochal cysts are predominantly a disease of children, the majority of which
      are female. The classical symptoms usually form part of a triad of jaundice,
      abdominal pain and a mass. The radiological features may be non specific and
      specific. Our experience of 21 cases with particular emphasis on the specific
      features which outline the cyst are presented.

PMID- 1012804
TI  - Segmental renal hypoplasia in childhood.
AB  - Radiological findings of segmental renal hypoplasia are reported, based on the
      observation of 6 children aged between 8 and 14. The leading clinical symptom is
      arterial hypertension. Urinary tract infection and proteinuria are additional
      common findings. Cases with bilateral disease often have renal failure. The
      intravenous urogram shows unilateral or bilateral small kidneys with segmental
      renal scarring and transverse lobulation. In the pathological areas the calyces
      are ectatic or clubbed and their infundibulum is elongated. Vesico-ureteral
      reflux is frequent. In angiography the lobulated segments appear hypovascular.
      Diagnosis was verified by histological examination.

PMID- 1012805
TI  - Urinary tract diseases in adolescence: a radiological and clinical view.
AB  - A total of 2,003 adolescent in-patients aged 14-19 years were studied. Of these
      801 (40 per cent) were found to have urinary tract disease. In 224 patients (28
      per cent) a previously undetected urinary tract anomaly was diagnosed: this
      number including 59 per cent of girls and 41 per cent of boys. This is the first
      analysis showing such a high frequency of urinary tract anomalies in clinical and
      radiological investigations during the period of adolescence. Of particular
      importance are minor anomalies, in so far as these are responsible for disorders
      to the flow of urine. It is thought that urinary tract anomalies manifest
      themselves in adolescence because of increased stress and a different pattern of
      life, as compared with that in the preceding era of childhood. The present paper
      shows the cardinal importance of radiological examination and of the
      radiologist's role in evaluating the dynamics of the process and the prognosis of
      the disease and, in helping to assess the future potential for physical stress in
      either work or sport.

PMID- 1012806
TI  - Hemihypertrophy in a boy with renal polycystic disease: varied patterns of
      presentation of renal polycystic disease in his family.
AB  - Hemihypertrophy is a condition that has been described in association with a
      variety of other malformations and diseases; quite often these have had a renal
      origin. -It is the purpose of this paper to record and discuss the occurrence of
      polycystic disease in a family, to note that the disease was manifest as either
      the "adult" or the "infantile" form, and detail the fact that one member of the
      family who had infantile type polycystic disease also had hemihypertrophy. -The
      pattern of inheritance of renal polycystic disease, its age at presentation and
      the variation in the boy of its manifestation with the passage of time are
      discussed. The need for caution in offering a prognosis and genetic counselling
      is stressed.

PMID- 1012807
TI  - [Involvement of the respiratory organs in lymphogranulomatosis in children].

PMID- 1012808
TI  - [Individual prognosis of the onset of acute leukemia remission based on the
      lactate dehydrogenase activity of the blast cells before treatment and the
      clinical factors influencing the efficacy of the prognosis].

PMID- 1012809
TI  - [Urgent problems of pediatric hematology].

PMID- 1012810
TI  - [Side effect of rubomycin on the myocardium during treatment of acute leukemia in
      children].

PMID- 1012811
TI  - [Myelopoiesis and the modern treatment of hypoplastic hematopoietic states in
      children].

PMID- 1012812
TI  - [Pathogenesis of anemias in children with rheumatism].

PMID- 1012813
TI  - [Glutamic acid in the overall treatment of deficiency anemias in children].

PMID- 1012814
TI  - [Pathogenesis of the hemorrhagic syndrome in hemmorrhagic vasculitis in
      children].

PMID- 1012815
TI  - [Serological signs of streptococcal infection in Schoenlein-Henoch disease
      (hemorrhagic vasculitis)in children].

PMID- 1012816
TI  - [Clinical picture and treatment of acute renal insufficiency].

PMID- 1012817
TI  - [Symptomatology and treatment of intranatal brain lesions in the newborn].

PMID- 1012818
TI  - [Errors in the diagnosis of mechanical jaundice in children].

PMID- 1012819
TI  - [2 cases of megaloblastic anemia in children].

PMID- 1012820
TI  - [Combination of a generalized form of mucoviscidosis and Silver-Russell
      Rubinstein syndrome in a newborn infant].

PMID- 1012821
TI  - [Case of death from bronchial asthma in a 13-year-old girl].

PMID- 1012823
TI  - [Laurence-Moon-Biedl-Bardet disease].

PMID- 1012822
TI  - [Resection of the left lobe of the liver for primary cancer in an 11-year-old
      child].

PMID- 1012824
TI  - [Case of mycosis (mucorosis) of the brain in a 5-month-old child].

PMID- 1012825
TI  - [Perforation of the wall of the large intestine by fruit seeds].

PMID- 1012826
TI  - [Relationship between the level of cholesterol, lecithin and nonesterified fatty
      acids and the state of the lipid depots in children with thyrotoxicosis].

PMID- 1012827
TI  - [Role of follicle-stimulating hormone in the process of sex maturation].

PMID- 1012828
TI  - [State of the somatotropic function of the adenohypophysis and lipid metabolism
      in growth disorders].

PMID- 1012829
TI  - [Effect of different levels of exogamy on the growth and sex maturation of
      children].

PMID- 1012830
TI  - [Insulinemia in pregnant women and parturients with diabetes mellitus and in
      their newborn infants].

PMID- 1012831
TI  - [Carbohydrate metabolism in children and adolescents in hereditary diabetes
      mellitus].

PMID- 1012832
TI  - [Immunoreactive insulin in children with hereditary diabetes mellitus].

PMID- 1012833
TI  - [Carbohydrate metabolism in children with duodenal ulcer].

PMID- 1012834
TI  - [Trace elements of blood in children with diabetes mellitus].

PMID- 1012835
TI  - [Hemodynamics in children and adolescents with diabetes mellitus at different
      developmental stages].

PMID- 1012836
TI  - [Characteristics of lipid metabolism in children with constitutional-exogenic
      obesity].

PMID- 1012837
TI  - [Growth hormone content of blood in health adolescents and in those with
      excessive weight and hereditary diabetes mellitus according to a standard glucose
      tolerance test].

PMID- 1012838
TI  - [Mechanism of development of lactic acidosis in obese children].

PMID- 1012839
TI  - [Phase analysis of the systole in obese children by means of polycardiography
      with Master's test].

PMID- 1012840
TI  - [Use of enteral foam oxygen therapy for the treatment of obesity in children].

PMID- 1012841
TI  - [Glucocorticoid function of the adrenal cortex in children with prolonged
      subfebrile condition].

PMID- 1012842
TI  - [Principles and methods of differential diagnosis of tuberculosis of
      intrathoracic lymph nodes in children].

PMID- 1012843
TI  - [Differential diagnosis of tuberculous synovitis in children].

PMID- 1012844
TI  - [Differential diagnosis of tuberculosis of the urinary system in children and
      adolescents].

PMID- 1012845
TI  - [Pathogenesis of chronic lymphadenitis in children after intradermal BCG
      vaccination].

PMID- 1012846
TI  - [Characteristics of epidemiological shifts among children and adolescents with
      tuberculosis under rural conditions].

PMID- 1012847
TI  - [Diagnosis and treatment of hereditary nephritis in children].

PMID- 1012848
TI  - [2 cases of pheochromocytoma in children].

PMID- 1012849
TI  - [Bladder puncture in children].

PMID- 1012850
TI  - [Study of the blood-meninges passage of ampicillin after venous administration in
      term and premature newborn infants].

PMID- 1012851
TI  - [Clinical and etiologic aspects of seasonal acute lung diseases in children].

PMID- 1012852
TI  - [Can we routinely screen fetal-maternal incompatibilities of the ABO system?
      Evalution of routine screening in obstetrics].

PMID- 1012853
TI  - [Phenotype of the 9 p- syndrome. Contribution of a further case].

PMID- 1012854
TI  - [Robertsonian translocation 13-22 in the father of a child with free trisomy 21].

PMID- 1012855
TI  - Performance of psychopathic and non-psychopathic delinquent girls on the Kahn
      Test of Symbol Arrangement.
AB  - MMPI classification of 9 delinquent girls as psychopathic or not did not
      distinguish their KTSA performance as hypothesized.

PMID- 1012856
TI  - Analysis of superiority of the right visual field in bilateral tachistoscopic
      word-recognition.
AB  - McKeever and Huling questioned procedures in experiments on lateral differences
      in the recognition of horizontally oriented multi-letter stimuli,
      tachistoscopically exposed bilaterally. They effected three major changes in this
      method and found superior scores for material in the right than left visual
      field, a result in the opposite direction of prior findings. Ideas from
      directional scanning and cerebral dominance accounts of lateral asymmetries
      suggest that McKeever and Huling's methodological innovations produced their
      result. Directional scanning notions indicate that horizontal targets impede
      measures of differences in processing skills of the cerebral hemispheres. These
      obstacles can be overcome by exposing vertically oriented targets.

PMID- 1012857
TI  - Arousal and cognition: word arousal and visual search.
AB  - The influence of target-word affective properties on information processing time
      in a high speed visual-search task was studied. The 24 words were embedded in
      random-letter matrices, with one word per matrix. Subjects (5 male, 5 female)
      were tested. Words extreme on emotionality (positive vs negative affect) yielded
      significantly longer latencies than neutral words. The results were discussed in
      the light of related list-learning and problem-solving research.

PMID- 1012858
TI  - Judged attractiveness in recognition memory of women's faces.
AB  - A series of 35 3 1/2 X 2 1/2-in., full-face photographs of female undergraduates
      were used as stimuli. Each subject rated the randomly presented photographs into
      high, medium, and low attractiveness and 2 hr. later subjects recognized
      photographs they judged most and least attractive significantly better than the
      more "neutral" faces when all were mixed with 10 previously unused control
      stimuli. Arousal and "distinctive cues" were discussed as possible explanations
      for the improved memory associated with attractive and unattractive faces.

PMID- 1012859
TI  - Behavioral analysis of clinical judgment.
AB  - Research on clinical judgment has produced conflicting information about effects
      of training on predictive accuracy, effects of the information available to the
      clinician, the correlates of accurate judgment, as well as the stability of such
      judgments. Such conflicting findings are largely related to lack of an adequate
      methodology. The present study examined the accuracy of judges making
      longitudinal clinical judgments with systematic increments in available
      information. Six judges, two non-experienced first-year graduate students in
      psychology, two medium-experienced practicum students, and two advanced interns,
      were asked to make discriminations between test protocols belonging to men
      convicted of first and second degree murder and men convicted of crimes against
      property. A discriminant function analysis classified 83% of these protocols
      accurately. Levels of information were increased in four phases. Most of the
      judges discriminated at a 50% accuracy level. No substantial increment in
      accuracy across phases was found. Judges of low accuracy discriminated best with
      the addition of the statistical findings. Daily judgments remained stable within
      the guessing range.

PMID- 1012860
TI  - Cognitive style, hemispheric specialization, and tested abilities of transsexuals
      and nontranssexuals.
AB  - Tests on which the 12 males and the 8 male transsexuals differed significantly
      and might be useful to clinicians for differentiation were the Embedded-figures
      Test, the Porteus Mazes, and the O'Connor Finger Dexterity Test. Sex differences
      emerged on the Embedded-figures Test and the first half of the dexterity test.
      There were no significant differences between 12 males and 14 females or males
      and 8 transsexuals on conjugate lateral eye movement, eye dominance, Digit Span,
      and Digit Symbol. Embedded-figures Test appears to tap some aspect of gender
      identity (males with female identities respond like females) while the first half
      of the O'Connor taps a biologically determined sex difference (males respond
      alike whether they have male or female identities).

PMID- 1012861
TI  - Control of fingertip temperature increases via biofeedback in learning-disabled
      and normal children.
AB  - Although considerable research has been done with biofeedback in adults, little
      is known of its effect in children of different ages or those with learning
      disabilities. This study assessed the effects of thermal biofeedback in 60
      children (40 boys, 20 girls) aged 7 to 9 yr. (Mage 8-6) half of whom were
      learning-disabled and half, normal children matched for age, sex, grade, race,
      socioeconomic status, and IQ. Training consisted on one 15-min. period daily for
      five days with three trials per period. Children (16 learning-disabled, 16
      normals) received consistent reinforcement for digital temperature increases
      while 28 children (14 learning-disabled, 14 normals) received mixed reinforcement
      after Day 1, on which all children were consistently reinforced to yield a
      performance baseline. Feedback was provided by a variable intensity light and toy
      electric train. Learning was demonstrated only for the consistently reinforced
      group, which performed almost twice as well as those receiving mixed
      reinforcement. Learning-disabled children learned thermal control even better
      than normals, explained in terms of biofeedback reinforcing an internal steady
      state conducive to learning. Younger children did better than older children, and
      girls did somewhat better than boys. Post-training improvement in figure-ground
      discrimination and intersensory-integration was linked with performance and
      learning, respectively.

PMID- 1012862
TI  - Sex-deviant handwriting and neuroticism.

PMID- 1012863
TI  - Interrelationships of perceptual modality, short-term memory and reading
      achievement.
AB  - Visual and auditory components of short-term memory and perception were used as
      predictors of vocabulary and comprehension components of reading for 72 children
      from Grades 2 to 5 in a low socio-economic rural school. All six variables were
      significantly intercorrelated (with the exception of visual short-term memory and
      auditory perception). When canonical correlation analysis was applied using the
      four scores measuring short-term memory and perception as predictors of the two
      reading scores, one was significant, and each variable made a significant
      contribution. Not only are short-term memory and perception a part of learning to
      read but both visual and auditory channels are important.

PMID- 1012865
TI  - Multivariate comparison of Howes' and Weisenburg and McBride's models of aphasia
      on the neurosensory center comprehensive examination.
AB  - The verbal production of 57 aphasic patients was rated and used to assign these
      patients into two sets of groups reflecting Howes' and Weisenburg and McBride's
      models of aphasia. Test scores covering a broad range of communication skills and
      modalities were compared between these groups to examine the assumption that
      salient features of verbal production could be used to establish groups which
      would show significant differences on other important linguistic variables.
      Neither Howes' nor Weisenburg and McBride's model provided groups showing
      significant multivariate differences. It was suggested that these models be
      improved by expanding them to include other important psycholinguistic components
      of language skills. Since these models did not account for significant between
      group differences, caution was suggested in using these models for assessment or
      treatment purposes.

PMID- 1012864
TI  - Temporal patterns of drug use - a pilot study.
AB  - Examination of pilot data for classes of drugs showed significant coefficients of
      concordance for ranked times of most common to least common use. Marijuana,
      psychedelics, and amphetamines were used most commonly from 6 to 10 p.m.,
      coincidental with temporal patterns for viewing television suggests recreational
      use. Use times for caffeine were completely different.

PMID- 1012866
TI  - Interpersonal touch in high school relative to sex and race.
AB  - Previous studies have indicated that interpersonal touch decreases from
      kindergarten through junior high. In the present study 1154 pairs of high school
      students were observed in school cafeteria queues. Instances of touch were
      recorded along with body parts used to touch and touched. High school students
      were observed to segregate themselves by race and sex as did the primary and
      junior high students in the earlier studies. Touch was not less probable than
      that observed in younger students. Cross-sex touch was not more frequent as had
      been predicted. Touch was highest among black students. An increase in aggressive
      touch seen in female junior high students was not observed in the present study.

PMID- 1012867
TI  - Validation of social self-esteem and an experimental index of delinquent
      behavior.
AB  - 30 male adolescents were administered a checklist of their delinquent behavior
      and the measure of social self-esteem designed by Ziller, Hagey, Smith, and Long
      (1969). A Pearson correlation of --.26 was found between self-esteem and scores
      on the delinquent behavior checklist. At a later session 18 of the subjects were
      assigned a puzzle-solving task which served as a measure of cheating. A
      significant relation between cheating scores and self-reported delinquent
      behavior indicated that the puzzle-solving task may be useful for measuring level
      of delinquency in an experimental setting.

PMID- 1012868
TI  - Relation of general activity in rats to environmental temperature.
AB  - The relation between ambient temperature and amount and pattern of wheel running
      was examined in four experiments, with a total of 88 adult male albino rats of
      the Sprague-Dawley strain, under conditions of 12-hr. light/12-hr. dark. While
      lowering of temperature from baseline of 21--25 degrees C to 4--7 degrees C most
      typically led to increased running, consistently reduced running characterized a
      substantial number of individuals, especially those with relatively high baseline
      scores. When comparison trials were run at 27 degrees C, reduced activity was
      recorded for virtually all subjects. As temperature was elevated above 27 degrees
      C, however, there was in most cases an upturn. At 34 degrees C, 24-hr. running
      scores tended to exceed baseline level for about half the animals, and running
      during the light 12 hr. of the day was above baseline for virtually all. Analysis
      of the temporal distribution suggests that the thermoregulatory reduction of
      activity, readily demonstrated at the moderately warm temperature, is complicated
      by efforts to escape as the environment becomes aversively hot. Failure of
      previous investigators to observe this is attributable in part to apparatus and
      recording differences. It is speculated that the pattern of response to extreme
      temperatures is closely related to the circadian fluctuation of internal
      temperature.

PMID- 1012869
TI  - Social reinforcement in block design performance by brain-damaged, emotionally
      disturbed, and non-disturbed retardates.
AB  - 48 retarded adults, equally divided by sex in three diagnostic categories (brain
      damaged, nondamaged disturbed, and nondamaged-nondisturbed) were assigned to
      posttest reinforcement or control conditions on the basis of CA, IQ, and pretest
      performance on the Block Design. Reinforced subjects were praised for each
      individual correct block placement on the posttrest; control subjects repeated
      the test without reinforcement. Both brain-damaged and non-damaged-nondisturbed
      subjects showed accuracy gains under reinforcement, while nondamaged-disturbed
      subjects decreased in accuracy. Failure to replicate previous differential
      reinforcement effects with brain-damaged and nondamaged-nondisturbed subjects,
      and the discrepant reinforcement effect on nondamaged-disturbed subjects, did not
      support the use of reinforcement of performance on the Block Design test as an
      aid in detecting organic damage.

PMID- 1012870
TI  - Saccadic eye movements in the presence of acoustic feedback.

PMID- 1012871
TI  - Effects of ethanol and tobacco on time judgment.
AB  - To determine the effects of the joint administration of tobacco and ethanol on
      short-interval time production and to search for differences between the
      ascending, the peak and the descending limb of the blood alcohol curve, two
      groups of 6 male subjects were tested on intervals of 1.5, 4.0 and 9.0 sec.
      Ethanol at 0.06% and 0.08% blood alcohol significantly lengthened the scores and
      one cigarette produced lower scores. The relationship between level of blood
      alcohol and time scores reversed in the latter part of the test session. The
      results are discussed in terms of effects of drugs on arousal systems.

PMID- 1012872
TI  - Selected visual abilities of college football players.
AB  - Relationships between visual abilities and athletic performance have been
      examined but reported findings are inconclusive and inconsistent. Data were
      collected from 40 volunteer college football players on horizontal peripheral
      vision, vertical peripheral vision, depth perception, and visual disembedding. No
      differences were found between varsity and junior varsity football players,
      indicating that relatively more successful players are not characterized by
      greater visual perception attributes.

PMID- 1012873
TI  - The construct validity of aniseikonic lens measures of anxiety.
AB  - The construct validity of aniseikonic lens measures of anxiety as a personality
      trait and of anxiety toward objects was examined in an experimental setting. No
      evidence of convergent construct validity was found for aniseikonic measures of
      anxiety as a personality trait. The validity of such measures as indices of
      anxiety toward objects was also questioned. The findings suggested that
      familiarity with the object viewed, rather than anxiety, may be the underlying
      dimension tapped by such measures of ability to perceive aniseikonic distortion.

PMID- 1012874
TI  - Personality self-perceptions of male heart patients and their wives: issues of
      congruence and "coronary personality".
AB  - This study examines personality self-ratings of 283 married men who had recently
      experienced a first myocardial infarction and who previously had been free from
      major disease. Similar data were collected from their "non-cardiac" wives.
      Results indicated that several traits often identified as descriptive of
      "coronary-prone" personality had high mean ratings in both husband and wife
      populations. In addition, factor analysis revealed a similar pattern of factors
      in each group. However, inspection of correlations showed for individual items,
      men with so-called "coronary-prone" personality traits did not generally have
      wives with these traits. Husbands and wives tended to agree regarding each
      other's personality self-ratings. Implications of these husband-wife data are
      discussed in regard to questions on the role of "coronary-prone" personality in
      heart disease.

PMID- 1012875
TI  - Effects of nursing apparel upon psychiatric inpatients' behavior.
AB  - To examine the effects of three modes of nursing attire on the behaviors, e.g.,
      aggressive behavior, leaving the unit against medical advice, of psychiatric
      inpatients, nurses were clad in white uniforms for 6 wk., then in street clothes
      for 6 wk., optional dress for 6 wk., street clothes for 3 wk., white uniforms for
      3 wk., and optional dress for 3 wk. Data from each mode were combined, yielding
      three experimental conditions. Results showed the greatest rates of maladaptive
      behaviors occurred during the white uniforms condition followed by the optional
      and street clothes conditions, respectively. An explanation of this outcome based
      upon patient's expectations was presented.

PMID- 1012876
TI  - Assessment of conceptual deficits in brain-damaged and schizophrenic patients.
AB  - Five concept-formation scores for 20 brain-damaged and 20 schizophrenic
      inpatients were factor analyzed, along with WAIS Vocabulary and Block Design. One
      factor emerged from this analysis, suggesting that these concept-formation tests
      do not measure an ability which is greatly different from general intelligence
      when administered to patients of the type studied. None of the single concept
      formation scores discriminated between the brain-damaged and schizophrenic groups
      independently of general intellectual level, although an exploratory analysis of
      the subtests of the Halstead Category Test indicated that differential
      performance on Subtest IV versus Subtest V produced valid criterion variance
      beyond that attributable to Vocabulary and Block Design alone. The findings were
      discussed in terms both of the factors underlying the performance of the present
      subjects versus those from different patient populations, and the need for
      refining ability-oriented diagnostic strategies when studying impaired patients
      who do not manifest highly specific psychological deficits on standard clinical
      tests yielding single scores.

PMID- 1012877
TI  - Inhibitory effect of unilateral contraction on the contralateral arm.
AB  - Electromyograms of the triceps and biceps brachii of both arms of 6 subjects were
      recorded in reaction trials to flashing stimulus. Rapid voluntary elbow extension
      was immediately preceded by a silent period of the unexercised contralateral
      agonist (contralateral agonist silent period). Since this silent period was not
      accompanied by a contralateral antagonist contraction, the contralateral agonist
      silent period was not attributable to reciprocal inhibition in the spinal levels.

PMID- 1012878
TI  - Visual acuity at hyperbaric air pressure.
AB  - The visual acuity of five divers in a dry pressure chamber was measured with a
      Landolt C test. Only one of them showed a significant reduction at 7.0 atm. These
      results contrast sharply with open sea experiments, which show a considerable
      reduction at much lower pressures (Baddeley, 1968). It is suggested that besides
      stresses, luminance differences, also turbidity, as a function of depth may
      account for the discrepancy.

PMID- 1012879
TI  - Treatment of insomnia through eidetic imagery: a new technique.

PMID- 1012880
TI  - Retention of learned temperature changes during problem solving.
AB  - In 2 studies (ns = 10, 9) college students were trained using biofeedback to
      lower or to raise finger temperature. Successful subjects were then asked to do
      distracting intellectual tasks, while simultaneously retaining the learned
      temperature changes. Results indicated that these changes could be maintained
      without detectable decreases in problem-solving efficiency in terms of either
      time or number of errors. These findings suggested that it might be possible for
      subjects to function efficiently outside the laboratory in their everyday
      activities while simultaneously exercising voluntary control over some autonomic
      processes.

PMID- 1012881
TI  - Extraordinary experiences during cross-modal perception.
AB  - 9 Ss were requested to perceive simultaneously the taste of beer and a rhythmic
      sound, the pitch of which could be varied. The frequencies at which Ss
      experienced harmony between the taste and the sound were determined. At the pitch
      of harmony Ss reported characteristic experiences, e.g., optimum taste of the
      beer, rhythmic sensations in the head, and tickling sensations in the jaws and
      the mouth. 3 Ss also reported experiences resembling those described by persons
      under the influence of such drugs as mescaline, psilocybin, LSD, and cannabis.

PMID- 1012882
TI  - Ear and hand dominance and their relationship with reading retardation.
AB  - A dichotic listening task was used to compare the ear dominance of retarded
      readers and normal readers with clear right-limb preference. Younger (8.5 to 9.5
      yr.) and older (10 to 11 yr.) groups were tested with two levels of task
      difficulty. Although right ear dominance was more apparent in the younger than in
      the older children, there was no difference associated with reading ability; nor
      was task difficulty differentially relevant. It was concluded that, at least for
      right-handers, reading retardation is unrelated to incomplete ear dominance.

PMID- 1012883
TI  - Reliability of the depression adjective check lists.
AB  - Data from 172 college subjects (93 males and 79 females) with mean age = 24.3 yr.
      (SD, 7.0) were used to replicate and extend previous findings on the alternate
      form, split-half and test-retest reliability for Set 2 (Forms E, F, G) of the
      Depression Adjective Check Lists (Lubin, 1967). Findings are reported for
      complete lists and for the two columns, i.e., "half lists."

PMID- 1012884
TI  - Differential correlates of Bender-Gestalt and Beery visual motor integration test
      for black and for white children.
AB  - The Bender-Gestalt and Beery Developmental Test of Visual Motor Integration were
      administered to 58 black and 33 white children, aged 10-5, mean IQ of 81, of
      comparable socioeconomic class. WISC, Peabody, Raven Matrices, and Wide Range
      Achievement Test scores were correlated separately for each racial group. No test
      appeared to have unique value in helping alleviate possible racial differences in
      test performance, correlated with achievement test scores at levels exceeding
      correlation of the WISC with such scores.

PMID- 1012885
TI  - Field dependency and perceptual cues in perception of two trapezoid illusions.
AB  - 40 males and 40 females rated as field-independent or field-dependent on the
      Group Embedded-figures Test were tested on two dynamic trapezoid illusions and
      made position judgments of static trapezoidal targets. Field-independent subjects
      reported more illusory experiences on the perception of rotation of an
      oscillating target than the perception of oscillation of a rotating target. The
      opposite was true for field-dependent subjects. Position judgments were related
      to the latter illusion but not the former. There was strong evidence of a
      differential use of perceptual cues for the two dependent groups.

PMID- 1012886
TI  - Nurses' perceptions of themselves, cancer nurses, typical, ideal and cancer
      patients.
AB  - The Activity Vector Analysis was administered to four independent samples of
      hospital staff nurses (40 working on surgical floors, 40 on medical floors, 10
      cancer specialists, and 10 in an outpatient department) to investigate
      differences in how nurses perceived themselves versus the type of nurse who works
      best with cancer patients, as well as differences in the perceptions of typical
      hospital patients, ideal patients, and cancer patients. Highly congruent
      stereotype clusters for the perception of the typical patient and cancer patient
      were found along with two less congruent stereotype clusters of the ideal patient
      and a stereotype cluster of perceptions of the cancer nurse. Both typical
      patients and typical cancer patients were seen as significantly below average in
      terms of their potential for action and were perceived as exercising less
      foresight, planning ability, moral judgment, and ethical conduct than nurses.

PMID- 1012887
TI  - Sex differences in self-perceptions as students of excellence and academic
      performance.
AB  - Differences between the sexes in self-ratings on 37 characteristics of a quality
      student, changes in their perceptions over a semester, and academic performances
      were analyzed for 172 male and 281 females. The characteristics were collapsed
      into five groups reflecting learning in class, study habits and attitudes, peer
      relationships, student-instructor relationships, and physical and emotional
      needs. Trend analyses showed significant differences (a) between the sexes on
      three grouped characteristics: learning in class, study habits and attitudes, and
      peer relationships (with females reporting higher ratings), (b) among the three
      self-rating sessions(reflecting upward trends) on all grouped characteristics,
      and (c) on one interaction, student-instructor relationships. Analysis of
      variance showed that the females obtained significantly higher grades than did
      the males.

PMID- 1012888
TI  - Attentiveness in behaviorally deviant and nondeviant children: I. Auditory
      vigilance performance.
AB  - The present study examined the vigilance performance of 16 behaviorally deviant
      and 16 nodeviant children and suggested that the vigilance paradigm might serve
      as a basis for a standardized test of continuous attention in children. The
      deviant and nondeviant children performed an auditory vigilance task administered
      on two separate occasions, 4 days apart. Performance during the first
      administration of the task deteriorated significantly for the deviant children as
      a function of time but not for the nondeviant ones. This finding was consistent
      with several prior clinical studies with children and suggested that the
      behaviorally deviant children were relatively less able to maintain a continuous
      level of attention. In addition, the vigilance procedure yielded relatively high
      test-retest reliability coefficients for both groups of children as well as
      performance which tended to vary as a function of chronological age.

PMID- 1012889
TI  - Relationships between introversion and perceptual accuracy.

PMID- 1012890
TI  - Successive visual reversal learning in rats as a function of amount of training
      per reversal and reduced spatial cues.
AB  - An experiment is reported which examined the effects of varying amounts of
      training per reversal over successive brightness discrimination reversals in
      rats, in a situation which reduced visual cues to spatial position. The results
      were similar to those of studies showing that amount of training affects
      successive reversal improvement on spatial problems but no differences were
      observed as a result of varying the cues for spatial position. The latter finding
      failed to confirm the result of a recent experiment in which a learning criterion
      was employed rather than a fixed-trials procedure.

PMID- 1012891
TI  - Effects of stimulus incongruity, task demand, and induced involvement on
      amplitude of GSR.
AB  - Previous investigations into the arousing effects of incongruity have not only
      reported inconsistent findings but have displayed the limitation of using only
      two levels of incongruity. An experiment using four levels of incongruity
      confirmed the hypothesized positive linear function between incongruity and
      arousal (as measured by GSR amplitude). However, the results of two additional
      experiments confirmed the hypothesis that the marked arousing effects of
      incongruity were attributable at least in part to the demands of the task
      employed which included subjects having to choose and verbally commit themselves
      to one of the alternatives. The interaction between incongruity and degree of
      involvement engendered by the task demand suggests that involvement may
      facilitate the arousing effects of additional collative variables such as
      novelty, uncertainty, and complexity.

PMID- 1012892
TI  - An assessment of dance therapy to improve retarded adults' body image.

PMID- 1012893
TI  - Modifications and influences of tactual preferences for shape and texture.
AB  - The effects of pretraining on tactual preferences for shape and texture and the
      effects of the preferences on discrimination learning were investigated in three
      experiments using kindergarten and third grade children. The pretraining
      experience significantly affected the dimensional preferences in both age groups,
      while an unexpected significant sex difference indicated a stronger texture
      preference in girls. Children tended to learn faster when the dimension they
      preferred was relevant to the task, but girls were affected more strongly than
      boys. In all experiments, the girls' behavior closely resembled that predicted
      for younger children.

PMID- 1012894
TI  - Changes in peer verbalizations accompanying individual and group contingencies to
      modify on-task behavior.
AB  - Group and individual contingency arrangements were alternately applied to modify
      the on-task performance of 5 behavior-disordered children. Concurrent records
      were maintained regarding the children's task-relevant (facilitating) and non
      task-relevant (inhibiting) verbalizations to peers. Both contingency arrangements
      were effective for controlling the children's on-task behavior while only the
      group contingency was associated with changes in their verbalizations.
      Specifically, the group contingency, as compared to the baseline and the
      individual contingency, was accompanied by a significant increase in facilitating
      verbalizations by peers. Moreover, the group contingency, in relation to the
      baseline but not the individual contingency, resulted in significantly fewer
      inhibiting verbalizations. The individual contingency did not affect either
      facilitating or inhibiting verbalizations of peers.

PMID- 1012895
TI  - Lateral eye movements, hypnotic susceptibility and field independence-dependence.
AB  - Previous research indicates that lateral eye movements are associated with
      hemispheric activity in the brain. In the present study involving 48 female
      subjects, "left-gazing" (right-hemispheric activity) was positively related to
      field-dependence, as measured by the Embedded Figures Test and the Stroop test,
      and also to hypnotic susceptibility. It was concluded that field-dependence and
      hypnotic susceptibility are both mediated by processes associated with right
      hemispheric activity.

PMID- 1012896
TI  - Competitive trait anxiety, success-failure and sex as determinants of motor
      performance.
AB  - Two experiments determined the effects of competitive trait anxiety, success
      failure, and sex on the performance of 10- to 12 yr.-old children competing on a
      complex motor maze. Competitive trait anxiety was assessed by the Sport
      Competition Anxiety Test and success-failure was induced by giving bogus win-loss
      feedback. High and low competitive trait-anxiety children were randomly assigned
      to one of three conditions: winning 80%, 50% or 20% of 20 contests. The average
      completion time and the variability of times within each of two blocks of 10
      contests were the two performance measures. State-anxiety was assessed with
      Spielberger's State Anxiety Inventory for Children as an indicant of arousal
      prior to and during competition. The findings of Exp. 1 yielded no significant
      performance differences. In Exp. 2 a significant interaction of competitive trait
      anxiety X success-failure X sex for performance time and variability was
      obtained. This interaction was largely attributed to sex differences.

PMID- 1012897
TI  - Relationship of need achievement to self-esteem: evidence for validity of Form B
      of Coopersmith's Self-Esteem Inventory.
AB  - Self-esteem scores, as measured by the recently developed short form of
      Coopersmith's Self-esteem Inventory (Self-esteem Institute 1974), were correlated
      with need achievement scores, as measured by Gough and Heilbrun's (1965)
      Adjective Check List. Self-esteem and need achievement were significantly related
      for male (N = 172) and female (N = 85) university students (p less than .001 and
      p less than .03, respectively). This finding was interpreted as providing a
      measure of concurrent validity for the short form of Coopersmith's Inventory.

PMID- 1012898
TI  - Problems encountered in development of instrumentation to measure figure-ground
      perception among young children.
AB  - The purpose of this study was to report problems encountered in the measurement
      of visual figure-ground perception. Conclusions from five related studies
      suggested that the skill may be a combination of related factors.

PMID- 1012899
TI  - Experience and latency to achieve stereopsis.
AB  - This study assessed perceptual learning effects with complex random-dot
      stereograms. Observers were shown the same complex anaglyph five times daily, for
      four consecutive days, and latencies to achieve stereopsis were recorded. Two
      factor repeated-measures analysis of variance yielded significant effects of
      days, trials, and days-by-trials interaction. Latency to achieve stereopsis
      decreases over trials each day, but this decrease is not completely transferred
      across days. It is concluded that obervers must, in some sense, "re-learn" how to
      perceive complex stereograms if subsequent presentations occur over more than one
      day.

PMID- 1012900
TI  - On scaling of future time.
AB  - Five future points of time (range: 1977 to 2034), described in terms of either
      (A) year number, or (B) "after N years," were scaled using two different types of
      scaling method. Subjective temporal distance was in each case a power function of
      chronological time, the exponent being consistently lower in Condition A than in
      B. A corresponding difference was found when subjects rated how threatening they
      experienced each of three events to be when the events were assumed to take place
      at the five alternative points of time. Experienced threat decreased
      exponentially with increasing temporal distance.

PMID- 1012901
TI  - Social relatedness and perceptual performance among the aged.
AB  - The author investigated whether the ability to shift mental sets as defined by
      Goldstein and Scheerer (1941) and measured by the ability to detect sequence
      changes in a film, is associated with the degree of social relatedness that older
      people have with society. 76 subjects, 16 men and 60 women, aged 60 to 88 yr.,
      were administered a questionnaire whose items were designed to measure social,
      personality and demographic variables. The subjects were also participants in a
      perceptual task. The trend of the findings suggests a relationship between
      efficiency of psychological functioning on a perceptual task and degree of
      interpersonal relatedness.

PMID- 1012902
TI  - Neural efficiency analyzer scores of reading disabled, normally reading and
      academically superior children.
AB  - Usefulness, under field-testing conditions, of one version of a Neural Efficiency
      Analygated. The equipment was said to measure efficiency of information
      processing as reflected in time between alternate EEG falling zero-crossing
      points. Special emphasis was placed on the difference score, a measure of right
      left hemisphere "efficiency" differences. Contrary to earlier reports, no
      significant differences were found between such scores of groups of reading
      disabled, normally reading, and academically superior children. Possible reasons
      for the negative findings are explored.

PMID- 1012903
TI  - Similarity between complexity on Role Construct Repertory Technique and
      articulation on Draw-A-Person test for patients and non-patients.
AB  - In an investigation of the underlying unity of the articulation of human figure
      drawings and personal construct complexity, moderate correlations were found, but
      in opposite directions, for inpatient and non-patient groups. For inpatients,
      greater construct complexity was associated with less sophisticated drawings. For
      non-patients, greater construct complexity was correlated with more sophisticated
      human figures. Mean and range differences in complexity and articulation scores
      between the two groups suggested that the higher complexity scores of the patient
      group indicated a loss of construct coordination, rather than greater
      articulation and organization of self and interpersonal experience.

PMID- 1012904
TI  - Performance of retardates on the Stroop Color-Word Test.
AB  - Institutionalized retardates were examined on a special format of a task
      requiring them to name the colors of 36 color patches and to name the color of
      the ink in which 36 incongruent color words were printed on separate cards. Mean
      reaction time for the incongruent condition was significantly longer than that
      for the color patches and the difference was independent of fatigue and stimulus
      size. The color-word interference effect previously reported with normal
      populations when given the Stroop test was demonstrated for this retarded sample
      using a special format.

PMID- 1012905
TI  - Glance, look, gaze, and stare: a vocabulary for eye-fixation research.

PMID- 1012906
TI  - Effects of verbal and pictorial materials on retarded youngsters' memory for
      information.
AB  - The effects of full and partial verbalization of information contained in
      pictures and of full verbalization without pictures on retarded youngsters'
      memory for information were examined. The subjects were 30 educable retardates
      and 30 normal controls. The results indicated that facilitation of recall for 13-
      to 15-yr.-old mentally retarded youngsters will occur with the use of pictures
      only if the aspects of the picture which are to be remembered are verbalized. The
      relevance of the findings for high-interest low-vocabulary textbooks for the
      retarded were discussed.

PMID- 1012907
TI  - Matching forms as a function of complexity, type of match, and retention
      interval.
AB  - The present experiment tested the hypothesis that nominal processing increases as
      stimulus complexity increases. Subjects indicated whether two 4- or 12-sided
      forms, separated by an interval of .5 or 4.0 sec., were the same or different.
      "Same" responses corresponded to matches for physical or nominal identity. Longer
      RTs for high complexity than low complexity forms suggest that complexity affects
      the efficiency of visual processing rather than the occurrence of nominal
      processing. An interaction between type of match and interval, due to the longer
      RTs for matches of nominally identical forms at only the .5-sec. interval,
      indicates that at this interval, matches for physical and nominal identity are
      made with visual and nominal representations respectively.

PMID- 1012908
TI  - Hand Test characteristics of marijuana-experienced and multiple-drug-using
      college students.
AB  - Three matched groups of 30 college student (17 males, 13 females) categorized as
      marijuana users, multiple-drug users, and complete abstainers were compared
      across 24 Hand Test scores. Both drug-using groups were characterized by
      significantly lower scores on Acquisition, Active, and Environmental responses.
      Results were interpreted as supporting the amotivational hypothesis that drug
      users display a lessened interest in environmental accomplishment. The marijuana
      group also proved to be slightly higher on the Exhibition score.

PMID- 1012909
TI  - Influence of auditory, visual, and audio-visual stimulus presentation methods on
      estimates of transition probability in speech.
AB  - Estimates of transition probability derived from auditory, visual, and audio
      visual presentations of stimulus material (40 simple conversational sentences)
      were compared for 3 groups of 100 college students and found to be highly
      correlated.

PMID- 1012910
TI  - Effects of intermittency of feedback on a compensatory tracking task.
AB  - Target intermittence in tracking has been studied as frequency of target
      presentation at various time intervals. Task efficiency increased as a function
      of increased frequency of target display in open-loop tracking tasks, where the
      steady state of presentation resulted in the best performance. The present study
      examined effects of feedback intermittency in compensatory tracking as a major
      source of disruption of the motor-sensory feedback process in the closed-loop
      tracking system. Feedback intermittency is defined as the feedback of momentary
      sampling of the difference between target movements and the operator's control
      motion for specified time lengths before being displayed to him in a continuous
      tracking task. With a random wave pattern of 9.76 cpm, 7 magnitudes of 0.0, 0.2,
      0.4, 0.6, 0.8, 1.0, and 1.5 sec. were used to represent various levels of
      feedback intermittency. Task efficiency decreased as a function of increased
      magnitudes of intermittency. Results are discussed relative to the difference
      between target intermittence and feedback intermittency and their effects on
      different tracking tasks. The findings also establish the concept of feedback
      intermittency as a disturbing factor in compensatory tracking in degrading the
      operator's performance.

PMID- 1012911
TI  - Appropriateness of the motor-free visual perception test when used with the
      trainable mentally retarded.

PMID- 1012912
TI  - The occurrence of feline infectious peritonitis in Denmark.
AB  - The clinical and pathologic findings in a case of feline infectious peritonitis
      (FIP) in a 1-year-old male cat are described. The cat had been sick for about 3
      weeks and presented itself clinically with depression, anorexia, dehydration,
      mild icterus and acites and a temperature of 39.5 degrees C. The sedimentation
      rate was elevated to 80 mm/30 min. An exploratory laparotomy was performed and
      ascitic fluid, found to be bacteriologically sterile, was collected.
      Pathologically, lesions involved both abdominal and thoracic serious membranes
      and viscera, especially the liver. They ranged from acute, focal necrosis or
      fibrino-necrotic changes to proliferative inflammation mainly characterized by
      infiltration with mononuclear cells. An identical disease was produced
      experimentally by intraperitoneal inoculation of ascitic fluid from the clinical
      case into 2 healthy cats. This is the first published report of the occurrence of
      FIP in Scandinavia.

PMID- 1012913
TI  - Milk somatic cells in dairy cows kept on pasture or confined indoors during the
      summer.
AB  - During the summer of 1975 (from June 30th to July 28th) weekly milk samples were
      obtained from 49 cows kept on pasture during the daytime, and from 48 cows which
      were confined indoors in stanchion barns and fed grass twice a day. The cows on
      pasture were exposed to relatively moderate temperatures, which were somewhat
      lower than for the indoor group (Table I). In the cows kept on pasture, an
      increase in the milk somatic cell content (MSCC) was observed throughout the
      experimental period, whereas no corresponding increase was recorded in the indoor
      group (Table III). This increase in MSCC appeared to occur primarily in non
      infected quarters (Table IV). The data from the present investigation seem to
      indicate that the seasonal increase in MSCC during the summer, which has been
      reported by several other investigators, cannot be directly related to
      environmental temperature per se.

PMID- 1012914
TI  - Oxytetracycline residues in meat and kidney tissue after intramuscular or
      intramammary treatment as determined by a chemical-physical method and compared
      to a microbiological method.
AB  - Two adult cows and three calves were treated intramuscularly with an
      oxytetracycline (OTC) preparation. The dose was about 5 mg/kg. The animals were
      slaughtered eight days after the treatment and their kidneys and muscle samples
      were taken for analysis. Twelve cows were treated intramammarily with an OTC
      preparation 12 hours before slaughter. Six of the cows were treated in two udder
      quarters with a preparation containing 200 mg OTC chloride per dose; the other
      six were similarly treated in four quarters with four doses. When the kidneys of
      all the animals were studied for the presence of inhibitory substances using the
      official Finnish microbiological meat inspection method, all were found negative.
      The OTC concentration of the different tissue samples was determined by a
      chemical-physical method, based on thin-layer chromatography and on the UV
      fluorescence of OTC. The muscle samples of the cows given OTC i.m. were negative
      except near the site of injection, where the concentrations were 4 mg and less
      than 0.5 mg (traces) per kg. The corresponding kidney concentrations of OTC were
      less than 0.5 and about 0.5 mg per kg respectively. All except one kidney sample
      of the calves given OTC i.m. were found to be negative. Traces of OTC (less than
      0.5 mg/kg) were found in all but one kidney sample of the cows treated
      intramammarily with OTC. Traces of OTC were found in two muscle samples of the
      cows treated intramammarily with 2 X 200 mg OTC and in two muscle samples of the
      cows similarly treated with 4 X 200 mg OTC. All the other samples were negative.
      The authors stress the need for a change in the present Finnish directives on the
      use of antibiotics in food animals.

PMID- 1012915
TI  - The occurrence of cyanide in certain smoked meat products.
AB  - Fifteen samples of smoked reindeer meat, two samples of smoked mutton from
      Iceland and five samples of smoked salamitype fermented sausage were analysed for
      their cyanide (CN) content by a steam distillation method. The mean cyanide
      content of the smoked reindeer meat was found to be 1.38 +/- 1.01 mg CH/kg, range
      0.27--4.27 mg/kg. The two smoked mutton samples, contained 1.93 and 1.78 mg CN/kg
      and the mean cyanide content of the five Salami samples was found to be 0.19 +/-
      0.13 mg CH/kg, range 0.06--0.40 mg/kg. The toxicological aspects of the findings
      are discussed, with special reference to the possible effects of nitrate and
      nitrite in the products.

PMID- 1012916
TI  - [Frequency of thalassemia in the South-East of France].
AB  - The ethnic and demographic characteristics of the Nice region are predisposing
      factors in the locally increased frequency of Thalassemia. The use of electronic
      blood-cell counters has enabled us to pick out easily all those patients
      presenting with microcytosis. In these patients, foetal hemoglobin,
      electrophoresis on cellulose acetate and level of hemaglobin A2 by the technique
      of miniature chromatography on DEAE-cellulose have been analyzed. 270
      heterozygotes thalassemics were found in 900 examinations. The statistical study
      shows an incidence 2% of beta-thalassemia in the Nice region.

PMID- 1012917
TI  - Hereditary thrombocytopathies with abnormal release reaction (author's transl).
AB  - The authors have examined 8 cases with Hermansky-Pudlak syndrome in whom besides
      the usual abnormalities of abnormal aggregation with collagen, absence of second
      wave of aggregation, reduction of the 5-HT uptake, presence of 5-HIAA in the
      platelets, two new abnormalities are described: the presence of a large amount of
      an unidentified metabolite after 5-HT incorporation which differs from 5-HT and 5
      hydroxytryptophol and an abnormal incorporation of labelled glycerol in the
      triglycerides. Correlation between abnormal lipid metabolism and defective 5-HT
      incorporation is discussed.

PMID- 1012918
TI  - [The platelet defect in myeloproliferative disorder (author's transl)].
AB  - Platelets functions are very often impaired in myeloproliferative disorders and
      acute leukemias. The abnormalities may either results from plasmatic factor
      affecting the platelet function or from an intrinsic platelet defect. The
      mechanism of the platelet defect is still a subject to discussion: it may be an
      abnormal response of the platelet to the aggregating agent or an impaired release
      of nucleotides.

PMID- 1012919
TI  - Dose distribution of 123I in the thyroid gland and its maximum permissible
      concentrations.
AB  - The calculation of the dose distribution in the thyroid tissues and of the
      maximum permissible concentrations in the air and in drinking water was carried
      out for 123I. In fact because of the recent use of this radionuclide in
      radioisotopic diagnostics the dose to both the patients' and operators' thyroids
      due to 123I must to be known. In order to obtain a correct estimate it is
      necessary, however, to consider the distribution of the radionuclide in the
      thyroid tissue and the changes in this distribution depending on the dimensions
      of the follicles. Taking into account the dose at the follicular cell-colloid
      interface, the maximum permissible concentrations in the air and in drinking
      water were calculated as being 6 x 10-8 muCi/cm3 and 4 x 10-4 muCi/cm3
      respectively.

PMID- 1012920
TI  - Some comparative studies using 99mTc and 131I in thyroid scanning.
AB  - By comparing thyroid scans made with 99mTc and 131I in 40 euthyroid goiter
      patients large discrepancies were found in 20% of all cases. For example, "warm"
      nodules on 99mTc scans were found to be "cold" on 131I scans, or a "cold" nodule
      on a 99mTc scan was observed as a "warm" one on a 131I scan. The above
      discrepancies seem to result from the differences in the metabolism of the two
      radioisotopes in the thyroid and those in the time which elapsed between the
      administration of the radioisotope and the execution of the scan. Generally
      speaking 99mTc thyroid scintigraphy should not be recommended as a routine
      technique in adults, its usefulness being limited to the cases in which 131I
      scans were found to be illegible. "Cold" nodules on 99mTc scans should also be
      reexamined after T3 stimulation.

PMID- 1012921
TI  - [Bone-seeking radioactive substances in nuclear medicine].
AB  - The concept of bone affinity of a radioactive tracer is developed on theoretical
      grounds and is discussed on the basis of the various substances used in nuclear
      medical diagnosis of bone disease. On the basis of results on the uptake of very
      short lived nuclides and extremely large molecules, evidence is provided that the
      incorporation of the tracer in the apatite crystal is not a primary criterion of
      bone affinity since incorporation cannot take place on timelimiting grounds in
      the former case and on spatial grounds in the latter. The fixation on bone is
      therefore more likely the result of non-specific adsorption processes. The
      utility of a radioactive substance in practical application in nuclear medicine
      depends on the radioactive characteristics of the nuclide and on its behavior in
      the organism. In this context the quality of the scintigram is particularly
      dependent on the mode and rate of elimination of that fraction of the tracer that
      is not bound by the skeleton. The various mechanism which cause differences in
      the uptake of tracer by healthy and pathological bone tissue are discussed with
      special regard to the role of blood flow.

PMID- 1012922
TI  - 99mTechnetium-unithiol complex, a new pharmaceutical for kidney scintigraphy.
AB  - The investigations were carried out with a newly synthesised, original 99mTc
      Unithiol complex (Unithiol-2,3-dimercaptopropansulphonate). It accumulates in the
      kidneys and enables their scintigraphic examination at 90--180 minutes after the
      administration. The study was performed on rats, rabbits and dogs. 99mTc-Unithiol
      complex accumulation in rat kidneys was 34,9%, 44,5% and 67,8% of dose after 1, 2
      and 3 h respectively. Good reability of the scintigraphic picture of the kidneys
      in rabbits and dogs confirms the accumulative capability of the complex in these
      organs. It was found by means of ascending paper chromatography that the purity
      of the 99mTc-Unithiol complex exceeded 90%.

PMID- 1012923
TI  - [Clinical significance of kidney imaging in bone scintigraphy].
AB  - The results of the examination of 62 patients who had undergone skeletal
      scintigraphy with 18-F and a urologic examination, were evaluated to determine
      whether the 18-F incorporation in the kidneys might indicate the presence of
      renal disease. Patients with and without renal disease demonstrated a similar 18
      F incorporation in the kidneys. Our data indicate that a side different 18-F
      renal activity is without clinical significance.

PMID- 1012924
TI  - Comparison of 99mTc-labelled hepatobiliary agents-- 99mTc-pyridoxylidene
      glutamate (99mTc-PG) and 99mTc-Sn-lidocaine iminodiacetic acid (99mTc-Sn-LIDA).
AB  - The time-course of excretion of two hepatobiliary radiopharmaceuticals, 99mTc
      pyridoxylidene glutamate (99mTc-PG) and 99mTc-Sn-lidocaine iminodiacetic acid
      (99mTc-Sn-LIDA), from the circulatorysystem to the parenchymal structures, and
      into the biliary duct and gastrointestinal tract in the same normal human
      subjects has been studied. The initial blood clearance is faster with 99mTc-Sn
      LIDA whereas the initial excretion form the gallbladder to the gut is a little
      faster with 99mTc-PG. Kidney uptake is seen with both the radiopharmaceuticals,
      and is a little more with 99mTc-PG.

PMID- 1012925
TI  - Lung uptake of colloid during liver-spleen scanning: a normal finding in
      children.
AB  - Sixteen (44%) of 36 normal children were observed to have faint lung uptake
      during liver-spleen scanning with 99mTc sulfur colloid from a commercially
      available kit. Visible radioactivity in the lungs of children during liver-spleen
      scanning should not be considered an abnormal finding.

PMID- 1012926
TI  - Adrenal scintigraphy with 131-I-adosterol.
AB  - A new adrenal scanning agent, Adosterol (131I-6beta-iodomethyl-19-norcholest
      5(10)-en-3beta-ol) has been evaluated in three female patients with
      hypercorticism. In one case, characterised by recurrent adrenocortical
      hyperactivity after bilateral adrenalectomy, a remnant of adrenal tissue was
      detected. In two other cases, the presence of an adrenal tumour could be
      excluded. The scan made on the 6th day after the administration of Adosterol was
      found to be superior in quality to that made on the 13th day.

PMID- 1012927
TI  - On the accumulation of 57Co by pancreas.
AB  - The in vivo distribution of various 57Co-labelled compounds has been studied.
      57Co-citrate is concentrated by pancreas and when injected together with ferric
      citrate the pancreas uptake is increased while it decreases in liver and kidney.

PMID- 1012928
TI  - Biological behavior of thiamine monophosphate and thiamine pyrophosphate labeled
      with technetium-99m.

PMID- 1012929
TI  - Effects of enzymatic treatment on radioactivity accumulation by tumors.

PMID- 1012930
TI  - [Estrogen profiles and breast carcinoma in women].

PMID- 1012931
TI  - [Case of apical lung carcinoma (superior sulcus tumor) treated with radiotherapy
      in combination with extended resection].

PMID- 1012932
TI  - [Results of telegammatherapy of lung carcinoma].

PMID- 1012933
TI  - [Invasive hypophyseal adenomas].

PMID- 1012934
TI  - [ETO method for the adjustment of intracavitary radiotherapy in patients with
      cervical carcinoma. A pilot study].

PMID- 1012935
TI  - [Applicators and methods of their fixation in the Gliwice method of radium
      treatment of cervical carcinoma according to the afterloading technic].

PMID- 1012936
TI  - [Teleradiotherapy in advanced cases of cervical carcinoma].

PMID- 1012937
TI  - [Results of radiotherapy in cases of cervical carcinoma infiltrating the vaginal
      wall].

PMID- 1012938
TI  - [Results of surgical treatment of invasive cervical carcinoma].

PMID- 1012939
TI  - Critical-point drying and gold sputtering as applied to scanning electron
      microscopy of human reproductive tissues.
AB  - Improved techniques have been developed for washing, pinning, fixation,
      dehydration and critical-point drying of tissues of female and male reproductive
      tracts, gametes, for viewing by scanning electron microscopy. The sputtering
      method, performed by an ion gun, is applied to shadow and produce a thin film of
      gold. Technical details and metal coating are noted which are suitable to improve
      images of surface ultrastructure of cilia and microvilli. Studies using scanning
      electron microscopy, histological and histochemical techniques, and
      cinematography are described.

PMID- 1012940
TI  - [A functional assessment of the masticatory muscles in mammals and humans].
AB  - We have amended and added to Fabian's tables giving a functional assessment of
      individual masticatory muscles. The data in our tables refer only to the
      temporalis, masseter, pterygoideus medialis, pterygoideus lateralis and
      digastricus muscles. The weights of these muscles were determined in three fixed
      human cadavers and the mean values compared with those of apes, carnivores,
      herbivores and rodents. In humans, the most powerful masticatory muscle is the M.
      temporalis, followed by the M. massater, as in apes and carnivores. The M.
      pterygoideus is also one of the most important. This is remarkable, since in the
      other groups this muscle occupies the last place. This relative strengthening of
      the M. pterygoideus lateralis is an important characteristic of the human
      masticatory apparatus. In humans, the difference between the relative weights of
      the individual masticatory muscles is not nearly so great as in other mammalian
      groups. The M. pterygoideus lateralis does lie close behind the other two big
      adductors (Mm temporalis and masseter) but, as regards power and weight, it
      hardly differs from the M. pterygoideus medialis and the M. digastricus. In
      humans the strengthening affects not only the M. pterygoideus lateralis but also
      the M. digastricus. It would seem that these two masticatory muscles could become
      the key to the understanding of the specific changes in human mastication.

PMID- 1012941
TI  - Lamellated osmiophilic bodies in mouse gallbladder epithelium.
AB  - Mouse gallbladder epithelium was studied in the electron microscope after
      glutaraldehyde and osmium tetroxide fixation and Epon embedding. Special
      attention was paid to dense cytoplasmic bodies. Heterogeneous dense bodies with
      osmiophilic and loose granular components were identified. Many of these bodies
      consisted of lamellated osmiophilic structures, similar to the phospholipid
      bodies of the large alveolar (type II) cells of the mammalian lung. The dense
      bodies containing the lamellar structures were membrane-limited and 0.5-1.0 mum
      in diameter. They were located in the supranuclear cytoplasma and were often
      closely associated with the Golgi apparatus. Acid phosphatase activity was
      demonstrated within these bodies and in some of the Golgi vacuoles. The contents
      were disposed in concentric lamellar osmiophilic structures, sometimes appearing
      as scroll-like configurations. These morphological findings were interpreted as
      indication of these presence of phosphlipid absorbed from the gallbladder lumen
      and stored in phagosomes in the central cytoplasm of the gallbladder epithelial
      cells.

PMID- 1012943
TI  - Enzyme histochemistry of rat interfascicular oligodendroglia, with special
      reference to 5'-nucleotidase.
AB  - The interfascicular oligodendroglia of the rat striatum nucleus is studied in
      control animals and under experimentally induced brain edemas. Enzyme
      histochemical studies were performed. Normal oligodendrocytes show two different
      enzymatic distributions. While Mg2+-ATPase, TPPase, TPPase, adenylate cyclase and
      SDH are shown to be situated at the cell bodies and some proximal processes, 5'
      nucleotidase reaction is seen at the cell fine distal processes. In spite of its
      trong activity in oligodendroglial endings the latter enzyme is not seen at the
      myelin sheath. This sheath and the interfascicular cells being intimately
      related, 5'-nucleotidase appears to be important not only during myelination, as
      almost all authors emphasize, but also in the adult myelin metabolism.
      Experimental brain edema shows some changes in the interfasicular oligodendroglia
      enzymatic activites for 5'-nucleotidase, Mg2+-ATPase and adenylate cyclase. A
      progressive disappearance of the former enzyme is observed. These features and
      those of derived from local ionic alterations may be concerned with the special
      susceptibility of white matter for some types of brain swellings.

PMID- 1012942
TI  - Fluorescence histochemical study of Aurbach's plexus of the ileum of 6
      hydroxydopamine-treated guinea pig.
AB  - In the present investigation the action of 6-hydroxydopamine (6-OHDA) on
      Auerbach's plexus of the ileum of the guinea pig has been studied with Falck and
      Hillarp's histochemical technique. A singel dose of 15-25 mg/kg of 6-OHDA causes
      degeneration of some of the adrenergic nerve fibres after 6 h of treatment. 200
      250 mg/kg of 6-OHDA is responsible for the total disappearance of nerve fibres in
      the ganglia and internodal strands within 24 h. 6 h after 100 mg/kg of 6-OHDA
      treatment, the intervaricose fibres have mostly disappeared and a few nerve
      fibres are swollen. The pre-terminal fibres are not much affected. After 24 and
      48 h of 100 mg/kg treatment with 6-OHDA, most of the varicose and non-varicose
      fibres have disappeared and very few fibres are left, these having become
      intensely fluorescent and much swollen, probably due to the accumulation of
      storage granules transported to this site by axoplasmic flow. After 6-8 days of
      treatment with 6-OHDA all the fluorescen fibres and cell bodies have disappeared.
      A few faintly fluorescent green and yellow cell bodies could also be observed;
      however, their chemical nature could not be determined.

PMID- 1012944
TI  - Effects of intense exercise on intracellular glycogen and fat in pigeon
      pectoralis.
AB  - The pigeon pectoralis muscle was electrically stimulated in vivo at a high
      intensity of 25 V and the intracellular glycogen and fat reserves of the muscle
      examined histochemically to determine the pattern of substrate utilization in the
      component broad white and narrow red fibre types during the intense flight
      simulated exercise. 4 h of continuous stimulation resulted in the depletion of
      intracellular glycogen from both fibre types and a simultaneous reduction in the
      intracellular fat stores of the red fibres. While glycogen provides the only
      source of energy for the white fibres, glycogen as well as fat serves as fuel for
      the red fibres. It is postulated that, though fat is the major fuel for the red
      fibres, their glycogen reserves are utilized to ensure a steady supply of
      oxaloacetate essential in the oxidation of fatty acids via the Krebs cycle, and
      that fatty acid catabolism helps to maintain gluconeogenesis.

PMID- 1012945
TI  - [Age-specific distribution of beta-glucuronidase and beta-galactosidase in the
      humeral epiphysis of rats].
AB  - The chondrocytes of the humeral epiphysis and of the articular cartilage of
      newborn, 8-, 30-, and 60-day-old albino rats contain beta-glucuronidase and beta
      galactosidase. Both enzymes were found to be rare in the before mentioned cells.
      The reactions begin in the cells of the column cartilage and of the osteoblasts
      of the metaphysis on the 8th day of life and demonstrate an additional activity
      in 40- to 60-day-old animals. The results mark the activity of the degrading
      enzymes of the carbohydrate metabolism.

PMID- 1012946
TI  - [The postnatal development of synapses at the dendrites of rabbit mitral cells].
AB  - Olfactory bulbs from 4 specimen of the 1st, 4th, 6th, 9th and 60th postnatal day
      were used. Relative mature unidirectional and reciprocal synapses are present at
      the mitral cell dendrites already at the first day. During postnatal development
      the amount of electrondense postsynaptic material increase. The vesicles were
      always spheric; their number increase significantly with age only at granule cell
      side of the reciprocal synapses. Length and width of the synaptic cleft do not
      change with age.

PMID- 1012947
TI  - Electron-microscopic identification of amoeboid microglia in the spinal cord of
      newborn rats.
AB  - Electron-microscopic studies in the spinal cord of neonatal rats show, though
      rarely, the existence of amoeboid microglial cells. The cells are distributed
      singly and are found only in the spinal grey matter. They are characterized by
      having a round, prominent nucleus with peripheral chromatin clumps. The cytoplasm
      is endowed with a well-developed Golgi complex, and isolated profiles of rough
      endoplasmic reticulum. One striking feature of the cytoplasm is the presence of
      abundant lysosome-like granules. The cytoplasm, which is of moderate density, may
      be vacuolated. The surface of the cells often sends out pseudopodium-like
      processes. These, together with the presence of occasional phagosomes, indicate
      that the amoeboid cells are phagocytic. Thus, it is possible to generalize from
      the present and earlier findings that amoeboid microglial cells are normal
      cellular constituents in the maturing central nervous system and their temporary
      existence in the neonatal stage indicates the necessity of these cells for
      subsequent maturation of the nervous tissue.

PMID- 1012948
TI  - Morphological, histochemical, autoradiographic and topographical evidences of the
      origin of the Langerhans' cell from the melanocyte in the skin of the guinea pig.
AB  - The microscopic anatomy of the nucleus, Golgi substance, mitochondria, etc. of
      type 1, 2, 3 and 4 albino melanocytes, type 01 and 011 albino intermediate cells
      of Billingham and Medawar and type I, II, III and IV albino Langerhans' cells of
      the albino guinea pig, is presented in detail. The study has demonstrated that
      the albino melanocytes degenerate through sequential stages of intermediate cells
      of Billingham and Medawar, type I, II and III Langerhans' cells to ultimately
      from type IV Langerhans' cells. It has been shown that all the dendritic cells of
      the epidermis belonged to one class of cells. Autoradiographic techniques have
      shown that type 3 and type 4 melanocytes, respectively, bearing 6 and 5 round
      tipped dendritic processes, divide by mitosis to form two daughter cells. One of
      these two daughter forms the intermediate cell of Billingham and Medawar. This
      cell, while transforming sequentially into type I, II, III and IV Langerhans'
      cells, moves up through the Malpighian and granular layers of cells, to the
      stratum corneum. This type IV Langerhans' cell is ultimately extruded out of the
      stratum corneum by exfoliation. The other daughter melanocyte remains at its
      place in the sub-basal zone to function as a mature melanocyte. The time for the
      passage of the daughter melanocyte to travel from the sub-basal zone to the
      stratum corneum layer was found to be 15 days.

PMID- 1012949
TI  - The King's Liver Unit-2.

PMID- 1012950
TI  - A reason to worry.

PMID- 1012951
TI  - A move ahead.

PMID- 1012952
TI  - Whooping cough.

PMID- 1012954
TI  - Quandary-3. Problems of conscience.

PMID- 1012953
TI  - Nursing care study: total dysphagia due to mild tetanus.

PMID- 1012955
TI  - The case of a Christmas Carol.

PMID- 1012956
TI  - Alcohol and the brain.

PMID- 1012957
TI  - The community psychiatric nurse.

PMID- 1012958
TI  - The intangible line.

PMID- 1012959
TI  - [Intracranial calcifications in Bourneville's disease (author's transl)].

PMID- 1012960
TI  - [Radiological symptomatology of cementomas (author's transl)].

PMID- 1012962
TI  - [Gastric mucosa prolapse into the duodenum (author's transl)].

PMID- 1012961
TI  - [Hyperlucent lung syndrome (author's transl)].

PMID- 1012963
TI  - [Splenic morphology in angiographic investigations (author's transl)].

PMID- 1012964
TI  - [Phonoangiography in the diagnosis of richly vascularized renal carcinoma
      (author's transl)].

PMID- 1012965
TI  - [Role of arteriography in diagnosis of abdominal tumours in children. Part V.
      Other abdominal tumours (adrenocortical, splenic and intestinal tumours)
      (author's transl)].

PMID- 1012966
TI  - [The value of radiotherapy in treatment of advanced laryngeal carcinoma (author's
      transl)].

PMID- 1012967
TI  - [The use of a typical projection table modified in an own way for universal
      angiographic investigations (author's transl)].

PMID- 1012968
TI  - [Adaptation of fluoroscopic screening 10 of X-ray unit TUR for performing
      aortoarteriography (author's transl)].

PMID- 1012969
TI  - [Protection of organism against unnecessary ionizing radiation in stomatology
      (author's transl)].

PMID- 1012970
TI  - Effect of ethanol on subcellular metal distribution in rat liver.
AB  - The effect of ethanol on the subcellular distribution of Mn, Cu, Zn, Mg and Cr in
      rat liver has been investigated. Significant changes in Mg, Zn and Mn
      distribution have been observed. No change in the microsomal Mn, Cu, Zn, Mg and
      Cr content has been found.

PMID- 1012971
TI  - The antitumor activity of certain substituted nucleosides.
AB  - Tests were made of the antitumor activity against lymphoid leukemic L 5178 Y
      cells in vitro, as exhibited by the following compounds: 2'-O-methyl-araC, 5'-0
      methyl-araC, N4,2'-O-dimethyl-araC, N4-methyl-araC, 2,2'-anhydro-5'-O-methyl
      araC, N4-methyl-2,2'-anhydro-araC, 4-thio-2,2'-anhydro-araU and 5-amino-araU
      being a new analogue or araC. The synthesis of the latter compound is described.
      The activity of 5-amino-araU was tested also in vivo against L 1210 mouse
      leukemia. O'-Alkylation, N4-exo-alkylation and the change in the amino group
      position from 4 to 5 abolishes the susceptibility of the above analogues to
      cytidine deaminase but at the same time it substantially reduces their cytotoxic
      activity. It was shown that 5-ethyl-2'-deoxyuridine inhibits 14 and 26% in vitro
      the growth of L 5178 Y cells at concentrations 10(-6) and 10(-5) M, respectively.
      The possible biological significance of the latter compound is discussed.

PMID- 1012972
TI  - Central effects of prostaglandins F2alpha and E1.
AB  - In male Wistar rats PGF2alpha or PGE1 were injected intracerebroventricularly
      (icv) in a dose of 1 or 10 mug. Immediately or 1 hr after injection the locomotor
      and exploratory activity were measured. The levels of noradrenaline (NA),
      dopamine (DA) 5-hydroxytryptamine (5-HT), 5-hydroxyindoleacetic acid (5-HIAA) and
      acetylcholine (Ach) were measured in discrete brain areas. Both PGs applied ivc
      caused the depression of locomotor and exploratory activity in rats. PGE1 acted
      longer. Both substances but PGE1 more intensively affected the level of estimated
      biogenic amines in different brain structures. It is concluded that PGF2alpha and
      E1 are central nervous depressants. Both PGs affect neurons producing NA or 5-HT
      or Ach in discrete areas of brain in different manner. There is different
      susceptibility of brain structures on PGs action.

PMID- 1012973
TI  - Studies on antilipolytic activity of antipyretics. Part II. Influence of sodium
      salicylate, aminophenazone, and acetophenidin on lipolysis stimulated by
      noradrenaline and aminophylline in vitro.
AB  - Lipolysis, expressed as muEq of FFA released from 1 g of epidydymal fat tissue
      per hour, was stimulated by noradrenaline (NA) and aminophyline. Sodium
      salicylate inhibited the lipolysis stimulated by NA, but not by aminophylline.
      Aminophenazone and acetophenidin inhibited the lipolysis stimulated either by NA
      or by aminophylline. The antipyretics inhibited stimulated lipolysis in a non
      competitive manner. The results suggest an important role of the action of
      antipyretics on lipolysis in their hypothermizing action.

PMID- 1012974
TI  - Lesions of midbrain raphe and ethanol narcosis in rats.
AB  - Serotonin -- depleting lesions involving nucleus raphe medianus markedly
      prolonged ethanol-induced sleep in rats. Lesioned animals showed increased
      general activity and decreased serotonin and 5-hydroxy-indoleacetic acid
      concentrations in the forebrain.

PMID- 1012975
TI  - Central action of prostaglandin F2alpha on circulatory system in rats.
AB  - PGF2alpha administered into the lateral brain ventricle of anesthetized rats
      caused an increase of the blood pressure and heart rate. Reserpine, chemical
      sympathectomy of the CNS with 6-hydroxydopamine (6-OHDA), atropine, and vagotomy
      weakened the central action of PGF2alpha on the peripheral circulation.
      Propranolol and phenoxybenzamine exerted no influence. Neither reserpine nor 6
      OHDA changed the influence of iv injected PGF2alpha on the circulation. The
      results of the experiments indicate to the participation of the central
      catecholamines in the mechanism of central action of the PGF2alpha on the
      circulatory system.

PMID- 1012976
TI  - Behavioural effects of dopamine and 5-hydroxytryptamine in centrally
      chemosympathectomized rats.
AB  - In rats central chemical sympathectomy (CCS) was elicited by intracerebro
      ventricular (icv) injection of two doses of 250 mug of 6-hydroxydopamine (6-OHDA)
      at 48 hr interval. 7 days after the last injection when full CCS is developed, 10
      mug of dopamine (DA) or 5-hydroxytryptamine (5-HT) were applied icv and locomotor
      and exploratory activity and irritability of animals were measured. CCS reversed
      the depressive effect of DA on the locomotor and exploratory activity, and
      intensified irribability of animals. It intensified the effect of 5-HT on the
      exploratory activity without changing the others observed behavioral parameters.
      It is concluded that CCS changes reactivity of central nervous system of
      pharmacological effects of DA and slightly affects the central response to 5-HT.

PMID- 1012977
TI  - Analysis of drug decomposition products. Part 34. Gas chromatography method for
      quantitative determination of METET in the presence of its sulfoxide.
AB  - Gas chromatographic method for the determination of METET in the presence of its
      oxydation product sulfoxide was worked out. The gas chromatographic conditions
      were: gas chromatograph--Chrom4CSSR,FID,N2-flow20--30cm3/min glass, column 100
      cm, phi 0-2 cm, 10% SE-30 on Chromosorb W 100/120 mesh, temp. 180--200 degrees C.
      The determination was carried by means of internal standard (phenylbutazone--PhB-
      1,2-diphenyl 4n-butyl pyrazolidino-3,5-dione or aminophenazone--APh--1-phenyl-2,3
      dimethyl-4-dimethylamino-pyrazolone-5) and the calibration curve was prepared.
      The ratio of peak heights for the determined comound and the standard was
      considered. The error of the METET determination expressed as standard percentage
      deviation was sr = 2--3% at n = 10.

PMID- 1012978
TI  - Derivatives of 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylic acid. II.
      Pirazolo-[3,4-d]-pyrimidine and hydrazinopyrimidine.
AB  - Heating of 2-hydroxy-4-mercapto-6-methylpyrimidine-5-carboxylic acid 1 with
      hydrazine or its derivatives in ethanolic solution gave 4-hydrazino derivatives
      10--12. However, at 150--160 degrees in the absence of a solvent after
      decarboxylation the 4-hydrazino derivatives 13 and 14 were formed. Under similar
      conditions form 2 (the ethyl ester of 1), 4-methylpyrazole-[3,4-d]-5(H)
      pyrimidine-3,6-dione and the corresponding 1--substituted derivatives 3,7,8 of
      this ring system were obtained. These compounds were easily chlorinated
      (POCl3/PCl5) in 6 and 3 and 6 position. Compounds 3 and 7 have strong cytostatic
      activity in vitro and in vivo, compound 13 acts as virostatic and
      antiinflammatory.

PMID- 1012979
TI  - Studies on the polymorphism of barbital.
AB  - Crystalline samples of barbital obtained by isothermal crystallization from
      various solvents or by sublimation were analysed. Morphological,
      thermomicroscopical, thermal, IR, density and initial dissolution rate studies
      were carried out. X-ray analysis according to Debye-Scherrer was realised after 9
      month storage of samples at room conditions. The ability of barbital to form
      polymorphic modifications was confirmed but the conclusions of previous works
      were discussed. It was found that the stability of metastable crystal structures
      II, III and IV was high enough to make them commercially feasible.

PMID- 1012980
TI  - Derivatives of 3-p-chlorophenyl-3-oxopropane and 3-p-chlorophenyl-3
      hydroxypropane-1-carboxylic acids.
AB  - Starting from gamma-chlorophenyltetrahydro- and gamma-chlorophenyldihydro-furan-2
      ones (2 and 12), some new amides and hydrazides of the acids mentioned in the
      title were prepared (Table 1 and 2). Of the obtained compounds the following 10,
      14, 15, 17, 20--23 show central depressant action.

PMID- 1012981
TI  - The effect of intrahippocampal administration of dopamine or apomorphine on EEG
      of limbic structures in the rabbit brain.
AB  - The effect of intrahippocampal injections of dopamine or apomorphine on the
      energy level of EEG from limbic structures in the rabbit was investigated. The
      EEG was recorded from gyrus cinguli anterior, hippocampus dorsalis, nucleus
      amygdalae, hypothalamus medialis, and nucleus caudatus. Both apomorphine and
      dopamine in doses used produced stimulatory effects. The effect of apomorphine
      did not appear after pretreatment with haloperidol (2 or 24 hr, 1 mg/kg sc). This
      suggests the presence of dopamine receptors of stimulatory type in the dorsal
      part of rabbit hippocampus. The data confirm the prolonged action of haloperidol.

PMID- 1012982
TI  - An attempt to correlate the development of tolerance to delta-9
      tetrahydrocannabinol and d-amphetamine with their subcellular distribution in rat
      brain.
AB  - The daily application in rats of d-amphetamine during 4 weeks in increasing doses
      from 16-80 mg/kg/day developed a tolerance. The quantitative evaluation of the
      relative accumulation of unchanged d-amphetamine in different subcellular brain
      fractions estimated with 3H labelled d-amphetamine showed that the development of
      tolerance to amphetamine is not associated with a decreased accumulation of the
      unchanged drug in any subcellular fraction of the brain. Synthetic delta-9
      tetrahydrocannabinol (THC) was injected (10 mg/kg) to rats twice daily. After the
      9th injection the intensity of the initial depressant effect was approximately
      similar to that after one injection but completely disappeared after 3 hrs of
      treatment. The specific activities of delta-9-THC and its metabolites in brain
      subcellular fractions were estimated with use of 3H-delta-9-THC. The tolerance to
      delta-9-THC in contrast to amphetamine seems to be mainly metabolic.

PMID- 1012983
TI  - Effects of inhibitors of the catecholamine synthesis on motor activity in the rat
      during light and darkness.
AB  - Under controlled conditions of light and darkness (12:12 hrs) the influence of
      inhibitors of the tyrosine-hydroxylase (alpha-MT) and dopamine-beta-hydroxylase
      (FLA 63) on motor activity were investigated in male Wistar rats at different
      times of the day. Simultaneously, turnover experiments of the cerebral
      noradrenaline and dopamine were performed, which revealed diurnal variations
      within 24 hrs of a day. Both inhibitors showed clear-cut chronopharmacological
      differences in influencing motor activity, and a phase shift between the darkness
      induced increase in motor activity and the maximum turnover rate of the cerebral
      dopamine was observed.

PMID- 1012984
TI  - Effects of lesions of monoaminergic system in the brain on the hypotensive
      effects of clonidine in rats.
AB  - Bilateral lesions of the locus coeruleus markedly reduced hypotensive effects of
      clonidine in rats. Lesions shifted laterally did not evoke any significant change
      of the hypotensive effects of clonidine or bradycardia induced by it. Lesions of
      the ventral and dorsal noradrenergic tract at the midbrain level and lesions of
      the midbrain raphe area failed to change hypotensive response to clonidine.

PMID- 1012985
TI  - Effects of stimulation of raphe nuclei on ponto-geniculo-occipital syndrome
      evoked by reserpine in cats.
AB  - Stimulation of the dorsal raphe nucleus in the cat caused inhibition of ponto
      geniculo-occipital waves induced by reserpine. Electrical stimuli with frequency
      of 10/sec. caused stronger effect than low-frequency impulses. The results
      indicate the PGO generating mechanisms (related probably with noradrenergic
      neurons of the nucleus locus coeruleus is suppressed by raphe nuclei.

PMID- 1012986
TI  - Studies on the central activity of kinins.
AB  - The influence of bradykinin and kallikrein on the levels of noradrenaline (NA),
      dopamine (DA) and serotonin (5-HT) as well as the influence of bradykinin on the
      levels of normetanephrine, homovanillic (HVA) and 5-hydroxyindoleacetic (5-HIAA)
      acids were investigated in different parts of the brain (cerebellum, corpus
      striatum, cortex, hippocampus, hypothalamus, medulla oblongata and midbrain).
      Kinins decrease the levels of NA and DA and their metabolites, and increase the
      level of 5-HT and 5-HIAA, expecially in corpus striatum and hypothalamus. The
      results of these investigations correlate with previously reported behavioural
      effects of kinins.

PMID- 1012987
TI  - Influence of kinins on amphetamine activity.
AB  - Bradykinin (2 mug ivc) or kallikrein (40 U/kg) inhibited the stimulatory
      psychomotoric action of a low (0.5 mg/kg) dose of amphetamine, and potentiated
      the action of a high (2 mg/kg) dose of the drug. A treatment with bradykinin and
      the low dose of amphetamine reduced the noradrenaline and enhanced the serotonin
      level in the striatum, and lowered the dopamine content in the cortex, while a
      combined treatment with the high dose of amphetamine elevated the dopamine level
      in the striatum and hypothalamus and depressed the serotonin level in the
      midbrain.

PMID- 1012988
TI  - Influence of fibrinogen degradation products (FDP) on the central action of
      acetylcholine.
AB  - Depressive behavioral effects of acetylcholine (10 mug ivtr) and physostigmine
      (0.3 mg/kg ip), and prolongation of the duration of electrogenic seizures
      produced by the drugs were prevented by intraperitoneal or intraventricular
      administration of FDP (0.5 mg/kg or 5 mug resp.). The peptides did not affect the
      brain acetylcholine level and did not influence the inhibitory effect of
      physostygmine on AChE activity.

PMID- 1012989
TI  - The influence of angiotensin on central effect of acetylcholine in rats.
AB  - The influence of angiotensin on the central action of acetylcholine was studied
      in rats. It was shown that the action of acetylcholine was enhanced in animals
      treated simultaneously with angiotensin. Above phenomena were accompanied with
      the increase of "free" and "bound" acetylcholine in the brain of angiotensin
      treated rats. These observations indicate an interaction between angiotensin and
      acetylcholine in the CNS.

PMID- 1012990
TI  - [Regulatory systems of contraction-relaxation cycle of muscle].

PMID- 1012991
TI  - [Biosynthesis of ether bonds containing analogues of phosphatidylocholines and
      phosphatidylethanolamines (author's transl)].

PMID- 1012992
TI  - [Intracellular transport of iron (author's transl)].

PMID- 1012993
TI  - Observations on the treatment of dissection of the aorta.
AB  - The results are presented of treatment in twenty-three patients with dissection
      of the thoracic aorta, in four of whom it was acute (less than 14 days'
      duration), and in nineteen chronic (more than 14 days' duration). Sixteen
      patients had Type I and II dissection (involving the ascending aorta) and five
      Type III  (descending aorta at or distal to the origin of the left subclavian
      artery); in two, dissection complicated coarctation of the aorta in the usual
      site. Thirteen patients had aortic regurgitation. Three of the patients with
      acute dissection were treated medically; two, both with Type I dissection, died,
      and the third, with Type III, survived. The remaining acute patient was treated
      surgically and also died. Of the patients with chronic dissection, eight were
      treated medically and eleven surgically. None of the medical group died in
      hospital; three died between 3 months and 1 year, and five have survived from
      periods of 12-72 months. Eleven patients with chronic dissection were treated
      surgically; four died in hospital at or shortly after operation; and the
      remaining seven lived for periods of 12-84 months. The presentation, indications
      for surgical treatment and results are discussed. It is concluded that surgical
      treatment of chronic dissection may carry a higher initial mortality than
      medical, but that there may be slightly better overall long term results in the
      former. As this series was not selected randomly, because patients with
      complications were selected for surgery, and there are only a few patients in
      each group, the results do not permit firm conclusion regarding the relative
      merits of medical and surgical treatment. It is suggested that all patients
      should initially be treated medically but that surgical treatment should be
      considered if the dissection continues, if aortic regurgitation is severe, if an
      aneurysm develops or enlarges, if cardiac tamponade develops or there is evidence
      of progressive involvement of the branches of the aorta. Attention is drawn to
      the important syndrome of chronic dissecting aneurysm of the ascending aorta with
      severe aortic regurgitation which requires definitive surgical treatment and
      aortic valve replacement. The importance of adequate visualization of the origin
      and extent of the dissection as a preliminary to surgical treatment is stressed.

PMID- 1012994
TI  - A blood pressure clinic in a health centre.
AB  - Following a screening survey for hypertension in Renfrew, a blood pressure clinic
      was established in a health centre. Three hospital doctors, each working an
      average of two sessions weekly, saw 368 patients. A specially trained nurse
      played an important part in the running of the clinic. Attendance of patients was
      high, and defaulting amongst those needing treatment was low. Blood pressures
      were well controlled in 75% of the patients. The clinic has proved an acceptable
      method of managing large numbers of hypertensives without reference to hospital.

PMID- 1012995
TI  - Antidepressant blood levels in acute overdose.
AB  - Plasma antidepressant levels and clinical condition were measured sequentially
      for at least 24 hr in eight patients who presented with acute antidepressant
      overdosage. There was no evidence to suggest that a knowledge of the drug plasma
      levels had anything to offer in the management of a patient whose overdose
      included a tricyclic antidepressant.

PMID- 1012996
TI  - Scleritis and temporal arteritis.
AB  - Thirty consecutive patients with severe scleritis or episcleritis were  admitted
      as in-patients to the Medical Ophthalmology Unit and assessed for systemic
      disease. There were seventeen women and thirteen men. The mean age was 53 with a
      median of 57 (range 23-83). Eighteen of the patients had scleritis: eleven of
      these had evidence of connective tissue disease and three of them had temporal
      arteritis. Twelve patients had episcleritis: six of them had a collagen disease
      and one of them developed temporal arteritis. This high incidence of temporal
      arteritis in association with scleritis has not been previously reported. It is
      important to diagnose and treat overt temporal arteritis early with parenteral
      steroids so that ischaemic papillopathy can be avoided. A higher incidence of
      collagen diseases than previously described is reported in episcleritis. It is
      thought that this is secondary to selection since patients with the usual self
      limiting episcleritis are not normally referred for further in-patient
      investigation. In no patient was more than one significant diagnosis made. There
      was no significant medical illness in only 11% of patients with scleritis and 33%
      of patients with episcleritis. The majority of the non-collagen diseases (e.g.
      hypertension) were not previously recognized. In none of the patients with
      temporal arteritis was the diagnosis made before admission. It is concluded that
      full examination and investigation for underlying disease is indicated in both
      scleritis and severe episcleritis.

PMID- 1012997
TI  - The results of 100 small tissue biopsies of testis in male infertile patients.
AB  - The value of testicular biopsy in male infertility has recently been emphasized
      by Meinhard, McRae and Chisholm (1973), and the present authors agree with them
      that a biopsy is essential for the following reasons: (1) to establish a firm
      diagnosis; (2) to rationalize therapy on the basis of histological findings; (3)
      new developments in drug therapy and electronmicroscopic techniques will help to
      clarify many areas of doubt and uncertainty in this difficult field; (4) the
      diagnosis of 'sloughing' by itself may mask changes in germinal cell development
      which may be amenable to hormone therapy.

PMID- 1012998
TI  - Calculus disease of the urinary tract at a district hospital.
AB  - At a District General Hospital the organization of a clinic for the investigation
      and treatment of patients with calculus disease of the urinary tract is
      described. The way in which such a clinic may be orgainzed is discussed and the
      results presented. In patients with idiopathic hypercalciuria, sodium cellulose
      phosphate causes a significant reduction in urinary calcium levels when used in
      such a clinic.

PMID- 1012999
TI  - Penetration of digoxin into cerebrospinal fluid.
AB  - The concentration of digoxin in the cerebrospinal fluid (CSF) of ten patients
      receiving conventional oral doses of this cardiac glycoside has been measured by
      a radioimmunoassay technique. Digoxin was undetected in eight patients and barely
      detectable in two, suggesting the presence of a significant blood-CSF barrier for
      digoxin. The implication of these findings is discussed.

PMID- 1013000
TI  - The empty sella syndrome.
AB  - The empty sella syndrome (ESS) presents a varied clinical and radiographic
      picture. It may remain asymptomatic or may stimulate an intrasellar growth
      thereby causing diagnostic and therapeutic problems. An air encephalogram (AEG)
      is required for diagnosis. The purpose of this paper is to review the clinical
      and radiological features of the ESS and to discuss the pathogenetic mechanisms
      involved.

PMID- 1013001
TI  - Hereditary nephritis (with unusual renal histology): report of a first case from
      the West Indies.
AB  - A 21-year-old Grenadian girl undergoing investigation in Trinidad for anaemia was
      diagnosed as a case of hereditary nephritis. She had the clinical features of a
      nephropathy, nerve deafness and an ocular defect. Renal histology was exceptional
      in that in addition to the typical findings of a hereditary nephritis, cystic
      areas generally associated with medullary cystic disease were noted. Several
      members of the patient's maternal family were afflicted with either deafness
      visual distrubances or renal disease.

PMID- 1013002
TI  - Obstructive cholecystitis due to metastatic melanoma.
AB  - A patient with isolated metastases from cutaneous melanoma to the gall-bladder is
      reported. The patient presented clinically with obstructive cholecystitis. The
      course of melanoma is unpredictable and the possibility that an apparently
      unassociated condition is due to metastases should always be considered. Isolated
      metastases may respond well to radical surgery and reward the surgeon's efforts.

PMID- 1013003
TI  - Abetalipoproteinaemia. A case report with pathological studies.
AB  - The clinical and pathological features of a case of abetalipoproteinaemia in a 38
      year-old patient are described in detail. A feature not previously recorded was a
      marked reduction in the velocity of ocular horizontal saccadic movements.
      Pathological studies revealed an active chronic demyelinating process. The
      patient showed no response to large doses of vitamin E. The rationale for this
      therapy, and the possible reasons for its failure are discussed.

PMID- 1013004
TI  - Drug-induced hyponatraemia in psychogenic polydipsia.
AB  - Two patients with psychogenic polydipsia developed hyponatraemia, one in
      association with administration of hydrochlorothiazide and the other with that of
      tolbutamide. It is suggested that the increased fluid intake in such patients may
      make them more susceptible to the development of hyponatraemia from thiazide or
      sulphonylurea compounds.

PMID- 1013005
TI  - Familial anglo-oedema--a particularly severe form.
AB  - A case of hereditary angio-oedema is described together with the family history
      and manifestations in the father of the patient. The problems encountered in his
      management are discussed, including tracheostomy and genetic counselling.

PMID- 1013006
TI  - Spontaneous rupture of the spleen in infectious mononucleosis.
AB  - Two cases of spontaneous rupture of the spleen as a complication of infectious
      mononucleosis are reported. The literature is briefly reviewed and emphasis
      placed on the need for awareness of this rare complication.

PMID- 1013007
TI  - Does coronary surgery prolong life in comparison with medical management?
AB  - This analysis attempts to utilize natural history controls to answer the question
      as to whether coronary surgery prolongs life in comparison to medical management.
      Selected natural history studies are compared and contrasted in an effort to
      obtain an average survival curve for patients with coronary artery disease
      comparable to those presently being operated. The Duke University Medical Center
      series of concurrent operated and non-operated patients is reviewed to
      demonstrate the difference of prognosis of patients with coronary artery disease
      and the complexities involved in answering the question. It is concluded that, on
      average, coronary surgery does not prolong life in comparison to medical
      management over the span of 2-5 years. There may be certain higher risk patients
      whose lives may be prolonged by aortocoronary bypass surgery but more patients
      and more prolonged follow-up are needed fully to answer the question.

PMID- 1013009
TI  - Phaechromocytoma with unilateral renal artery stenosis.

PMID- 1013008
TI  - Idiopathic cervical and retroperitoneal fibrosis: report of a case treated with
      steroids.
AB  - Retroperitoneal fibrosis in a 12-year-old boy is reported. This was associated
      with a fibrotic mass in the neck which resolved spontaneously. Right-sided
      ureteric obstruction responded to treatment with steroids.

PMID- 1013010
TI  - The Oxford continuous blood-pressure recorder--technical and clinical evaluation.

PMID- 1013011
TI  - Electrocardiography: technical aspects. Introductory remarks.

PMID- 1013012
TI  - Median nerve palsy--a complication of brachial artery cannulation.

PMID- 1013013
TI  - Studies in a hypertensive population.

PMID- 1013014
TI  - The use of 24 hour blood pressure monitoring in the diagnosis and management of
      difficult hypertensive problems.

PMID- 1013015
TI  - The over-shoot phenomenon on withdrawal of clonidine therapy.

PMID- 1013016
TI  - The value of ambulatory monitoring in borderline and established hypertension.

PMID- 1013017
TI  - Methods for tape analysis (I).

PMID- 1013018
TI  - Monitoring of electrocardiogram and blood pressure in the intensive care unit
      with portable instruments.

PMID- 1013019
TI  - Ambulatory monitoring--applications in orthopaedics.

PMID- 1013020
TI  - The analysis of gastrointestinal myoelectric activity.

PMID- 1013021
TI  - Long-term recording of activity patterns.

PMID- 1013022
TI  - Methods for tape analysis (II).

PMID- 1013023
TI  - Analysis of heart rate in physiological and clinical studies.

PMID- 1013024
TI  - Long-term recording of the electrocardiogram in a normal population.

PMID- 1013025
TI  - The R-R interval histogram.

PMID- 1013026
TI  - Ambulatory monitoring in the late post-myocardial infarction period.

PMID- 1013027
TI  - Clinical application of Holter continuous electrocardiography.

PMID- 1013028
TI  - Measurement of physiological variables in men at work.

PMID- 1013029
TI  - An analysis of the use of active electrodes in electroencephalogram ambulatory
      monitoring.

PMID- 1013030
TI  - Electroencephalogram monitoring of ambulatory epileptic patients.

PMID- 1013031
TI  - Electroencephalogram recording of sleep in the home.

PMID- 1013032
TI  - Factors determining the design and construction of a portable pressure transducer
      system.

PMID- 1013033
TI  - [Estimation of cardio-respiratory energy reserves by ergometric exploration].
AB  - Beyond the usual respiratory functional tests, ergometry represents a
      complementary test, yielding much information on the functioning of the lung
      heart system. Simultaneous recording, studying and comparing different
      respiratory and haemodynamic functional parameters during effort, provides an
      objective appreciation of the cardio-respiratory energetic reserve. Such a study
      is necessary to estimate a functional handicap and to understand the
      pathophysiological alterations of the cardio-respiratory system. The estimation
      of energetic reserve based on the simultaneous study of multiple respiratory and
      circulatory parameters also provides valuable information. Ergometry is of equal
      value in the estimation of operating risks in pulmonary surgery. Information
      drawn from more than 600 ergometric tests composed of simultaneous recording of 8
      parameters (heart rate, ECG, pulse volume, spirogram, ventilation per minute,
      SAO2, capnogram, right ventricular pressure) have confirmed the great value of
      this method in pulmonary medicine.

PMID- 1013034
TI  - [Spontaneous pneumothorax in the adult. Problems of its development and treatment
      (apropos of 124 cases)].
AB  - The authors report their experience of the evolution and treatment of spontaneous
      pneumothorax in the adult, in a series of 124 cases, starting from January 1965
      to May 1975. Recurrences occur in 27% of cases whatever therapeutics are used.
      They discuss frequency and modality in relation to the etiology and the proposed
      treatment of pneumothorax.

PMID- 1013035
TI  - [71 pulmonary hamarto-chondromas].
AB  - Seventy-one hamarto-chondromas were operated on at the Centre Chirurgical Marie
      Lannelongue from January the 1st 1958 to September the 1st 1975. Pulmonary
      hamarto-chondroma is always a slowly evolving benign tumour, usually found in
      patients between 40 and 60, and twice as frequent in males as in females. There
      are two different kinds. 1) Intraparenchymal hamarto-chondromas, which have a
      noteworthy clinical latency and in 2 cases out of 3 are situated anteriorly and
      peripherally. The usual treatment consists of simple enucleation. 2)
      Endobronchial hamarto-chondromas, on the other hand, have a striking
      symptomatology of bronchial obstruction. If operated on after some delay, they
      will cause the destruction of distal parenchyma. Treatment depends on their
      topography. Segmental resection is often the sole recourse.

PMID- 1013036
TI  - [Value of echotomography in pleuro-pulmonary pathology].
AB  - Echotomography based on the use of ultrasound as a diagnostic tool, little used
      until now in pleuropulmonary pathology, seems interesting and valuable and
      diserves to be counted amongst the various paraclinical examinations. Out of a
      hundred patients, we obtained the following results: -- 91.7% success in the
      needle biopsies done after echotomography. -- 84.4% success in exploring
      peripheral pulmonary tumor. -- 100% success in plotting: pleural thickening in
      which figures obtained with ultrasounds are very close to those obtained directly
      by needle. Echotomography in pleuropulmonary pathology has the following
      indications: -- for pleura effusions, pleural thickening and tumors; -- for
      pulmonary parenchyma: evolving or stable, solid or liquid masses, that are close
      enough to the thoracic wall; -- for mediastinum: lesions localized in the
      anterior mediastinum and related to the sternocostal wall. In all these cases
      echotomography brings valuable complementary information, sometimes allowing the
      location of fibrohyalin pleural plaques of asbestosis invisible on X rays. By
      combining a wider experience and the perfectioning of the equipment, this method
      could become a common practice in pleural pathology and thoracic oncology.

PMID- 1013037
TI  - [Round table: Criteria of choice of function test in epidemiology].

PMID- 1013038
TI  - The stuffy nose.

PMID- 1013039
TI  - The early diagnosis of malignant neoplasms of the nose, pharynx and larynx.

PMID- 1013040
TI  - Hard of hearing.

PMID- 1013041
TI  - Abnormalities of smell and taste.

PMID- 1013042
TI  - Rhino-sinusitis and midfacial pain in adolescents.

PMID- 1013043
TI  - The physiological basis and practical value of head exercises in the treatment of
      vertigo.

PMID- 1013044
TI  - Severe pyrexial illness caused by middle ear disease.

PMID- 1013045
TI  - Severe haemolysis and unilateral sensorineural deafness in infectious
      mononucleosis.

PMID- 1013046
TI  - The psychosexual clinic.

PMID- 1013047
TI  - The prevalence of anaemia in the over-65s in a rural practice.

PMID- 1013048
TI  - Forensic problems in practice. XII. Injuries from fire-arms and explosives.

PMID- 1013049
TI  - [Controlled hypotension by sodium nitroprusside during neuroleptanalgesia,
      halothane-and enflurane anaesthesia at neurosurgical and maxillary-face-surgical
      operations (author's transl)].
AB  - A new sodium-nitroprusside-preparation (Nipruss) was tested in 40 patients for a
      controlled hypotension in neurosurgical as well as maxillary- and face-surgical
      operations. Differences between the phases of hypotension by Nipruss were pointed
      out for NLA, halothane- and enflurane-narcosis. An initial hypotension of -48 per
      cent, caused by Nipruss, was accompanied by an increase of the cardiac frequency
      of +33 per cent. This was dependent on the different methods of anaesthesia. The
      doses necessary for an average permanent hypotension of -36 per cent varied
      between 1.3 and 22.3mug/kg/min. The results proved, that Nipruss guarantees a
      diminished blood field even be  used without head-up-position and at moderate
      hypotension. In combination with halothane and enflurane, hypotension could be
      regulated easier than with NLA. However, this resulted often in a higher
      frequencyload of the heart, so that frequently beta-adrenergic blocking drugs had
      to be administered. The operation conditions were improved, incidents did not
      occur. The new preparation Nipruss has organizational and hygienic advantages.

PMID- 1013050
TI  - [Haemodynamic effects during hypotension with sodium nitroprusside neurosurgery
      (author's transl)].
AB  - Haemodynamic effects during hypotension with sodium nitroprusside in the surgery
      of cerebral aneurysms were studied in 16 patients. Sodium Nitroprusside caused
      arterial hypotension by a direct vascular musculotropic effect and it was found
      to reduce peripheral vasculare resistance, and to lower the bloodpressure in the
      right atrium and pulmonary arteries. Stroke volume decreased in the presence of
      tachycardia while there was no change in cardiac output. Its evanescent action
      and easy regulation make sodium nitroprusside suitable for controlled hypotension
      during cerebral surgery, especially since there are no negative haemodynamic
      effects.

PMID- 1013051
TI  - [Dosage problems of sodium nitroprusside (author's transl)].
AB  - Sodium nitroprusside has proved a useful completion of anaesthesiologist's
      armament. Nevertheless there still exist some doubts concerning correct dosage.
      This uncertainity is aggravated by communications in literature about fatal
      outcomes of hypotensions induced with this drug. For the patient's safety, we
      recommend not to exceed an infusion rate of 15mcg/kg/minute or a total of 1.5
      3mg/kg irrespective of the time of administration. In any case the development of
      metabolic acidosis or the occurence of tachyphylaxis or resistance should be a
      strong argument for discontinuing nitroprusside and changing to an other method
      of hypotensive anaesthesia. A useful aid is the control of infusion rate by the
      IVAC-531-machine.

PMID- 1013052
TI  - [Cardiodepressive effects due to ketamine, etomidate, methohexitone and
      propanidid. A clinical study by means of the systolic-time-intervals (author's
      transl)].
AB  - The cardiodepressive effects of ketamine (1mg/kg), etomidate (0.3mg/kg),
      methohexitone (1mg/kg) and propanidid (4mg/kg) have been compared by means of the
      systolic time intervals on patients during a steady-state halothane--N2O:02(1.1)-
      anaesthesia. This anaesthesia served as a pharmacological model of reduced
      myocardial function, and moreover, it should block the centrally-elicited cardiac
      stimulation by ketamine, thus unmasking the direct negative inotropic action of
      this anaesthetic. Ketamine and etomidate are of lesser cardiac depressant action
      than methohexitone or even propanidid. Diazepam (0.2-0.25mg/kg) proved to be able
      to attenuate or abolish, respectively, the ketamine-induced increases of heart
      rate and blood pressure in normo- and hypertensive patients, and might therefore
      be useful for induction anaesthesia in cardiac and coronary risk patients, as
      proved on two patients with recent myocardial infarction.

PMID- 1013053
TI  - [Ethrane in anaesthesia for children--measurement of cardiac output by impedance
      cardiography (author's transl)].
AB  - Ethrane permits a very smooth and quick introduction of anaesthesia per
      inhalationem without signs of any excitation due to its physical properties.
      Because of its low analgesic property it was necessary to administer nitrous
      oxide. After the interruption of Tthrane--administration our patients awoke
      without any nausea or vomiting. In our study we measured stroke-volume and
      cardiac output during and after Ethrane anaesthesia using the IFM-Minnesota
      Impedance Cardiograph 304 A. In the first ten minutes of anaesthesia we found a
      23 per cent-decrease of strokevolume, a 19 per cent cardiac output-decrease
      whereas the heartrate rose slightly. Any further significant changes of these
      parameters up to the end of anaesthesia were not detectable. Already two minutes
      after the end of Ethrane-administration all parameters had reached their initial
      values.

PMID- 1013054
TI  - [Malignant hyperthermia, chronic alcoholism and tubular aggregates (author's
      transl)].
AB  - A 24-year-old chronic alcoholic survived malignant hyperthermia which developed
      in connection with maxillo-facial operation. Electron-microscopic investigations
      of muscle biopsies disclosed so called tubular aggregates. The possible relations
      between these structures and the occurrence of malignant hyperthermia on the
      basis of an alcoholic myopathy are discussed. People suffering from idiopathic
      recurrent myoglobinuria have to be regarded as patients-at-risk.

PMID- 1013055
TI  - [Halothane concentrations in the atmosphere of a paediatric operating theatre
      (author's transl)].
AB  - Determinations were made of the halothane concentrations in the air of a
      paediatric operating theatre during operations. They averaged 5-30 p.p.m. with
      peaks of 50-70 p.p.m. during induction. The inhalation of halothane vapour was
      confirmed by demonstrating bromine metabolites in the urine of the operating room
      personnel. The risk attendant on chronic exposure to halothane vapour should be
      prevented by the installation of suitable systems for the removal of excess
      anaesthetic vapours.

PMID- 1013056
TI  - [Perforation of the right ventricle by a central venous catheter (author's
      transl)].
AB  - Two letal iatrogenic cardiac perforations by a subclavian catheter are reported.
      The cause of this rare but most serious complication is based on the sliding down
      of a subclavian catheter left in for 9 days in one case, in the other one on the
      introduction of a polyvinyl-catheter into the right ventricle.

PMID- 1013057
TI  - [Identification of the epidural space by air-fluid reflux (author's transl)].
AB  - Detection of the epidural space by Dogliotti's method with a Tuohy needle (inner
      gauge 1.6mm) is followed by introduction of 3.0-5.0 ml of test solution and rapid
      injection of 3.0-5.0 ml air with a 5.0ml syringe. After the introduction of the
      air, the syringe is immediately removed from the needle. Location of the needle
      tip in the epidural space is marked by air bubbles coated by a thin fluid film,
      which hang over the hub of the needle and then burst. In some instances a slight
      wheezing can be heard as the air introduced into the epidural space comes out.
      The air-fluid reflux is determined by the elasticity of the dura and points
      always at the location of the tip of the needle in the epidural space. This sign
      is present in 95 per cent of the cases. The intensity of the air-fluid reflux
      depends upon the elasticity of the dura, the diameter of the needle and of the
      syringe and the force by which the plunger is pushed down.

PMID- 1013058
TI  - [A simple system for the removal of excess anaesthetic vapours for use with the
      Jackson-Rees modification of Ayres' T-Piece (author's transl)].
AB  - Details are given of the arrangement and functioning of a simple anti-pollution
      system for use with anaesthetic apparatus without re-breathing.

PMID- 1013059
TI  - [A plastic lumbar puncture needle for epidural analgesia (author's transl)].
AB  - A new technique for epidural analgesia is described which involves the use of a
      plastic cannula through which the catheter is passed into the extradural space.
      The method was used in 10 cases. The advantages and disadvantages of the
      technique and possible improvements are discussed.

PMID- 1013060
TI  - [The results of liver biopsies during rifampicin therapy (author's transl)].

PMID- 1013061
TI  - [Psychotherapy for children and adolescents at the Institute for Psychogenic
      Diseases of the National Health Insurance in Berlin].

PMID- 1013063
TI  - [Tradition and creativity].

PMID- 1013062
TI  - [Separation conflicts and parental performance in adolescence].

PMID- 1013064
TI  - [Reflections on the theoretical and practical relationship between tradition and
      creativity].

PMID- 1013065
TI  - [My experiences as school psychologist with "gifted failures". Premature
      schooling and removal from one school to another as a reason for school
      failures].

PMID- 1013066
TI  - [Reflections on internal medicine and internists].

PMID- 1013067
TI  - [Present status of anticoagulant therapy].

PMID- 1013068
TI  - [Value of fetal hemoglobin in the diagnosis of neoplastic diseases].
AB  - In base of the actual interest on certain substances which measured in blood
      indicate the possible existence of neoplasic processes and because the elevation
      of fetal hemoglobin in patients with neoplasms or "pre-malignant" diseases, the
      authors of this paper decided investigate the levels of fetal hemoglobin in
      patients with neoplasic diseases, with and without treatment, comparing it with
      that obtained from a control group of healthy individuals or with infectious
      diseases, colagenopathies or bening tumours.

PMID- 1013069
TI  - [Solitary nodular pulmonary lesion. Anatomopathological study of 162 cases
      extirpated in surgery].

PMID- 1013070
TI  - [Pleural complication of the amebic liver abscess].

PMID- 1013071
TI  - [Arthrodesis of the hip using a cobra plate. Comments on preliminary reports].
AB  - Authors report 50 arthrodesis of the hip joint with AO cobra-plate, and consider
      that it's a difficult procedure that will be performed by capable surgeons. The
      complications are infections (26 per cent), inestability after surgery with bend
      and break of implants  occasioned by bad surgery. The most important badness was
      found by modifying the steps of the precise technique and our opinion is to
      perform exactly the arthrodesis of the hip joint as the AO group to obtain
      successful results (88 per cent).

PMID- 1013072
TI  - [Clinical trial with Nerisona--ointment].

PMID- 1013073
TI  - [Acidocylline in the treatment of acute bacterial tonsillitis].

PMID- 1013074
TI  - [Evaluation of Nerisona (cream) in eczemas].

PMID- 1013075
TI  - [Dermatomycosis. Use of a new antimycotic (tolcyclate) and therapeutic results].

PMID- 1013076
TI  - [The rate and significance of toxoplasma infection in Switzerland (author's
      transl)].

PMID- 1013077
TI  - [Primary (?) retroperitoneal seminoma with multiple metastases and elevated serum
      alkaline phosphatase (author's transl)].

PMID- 1013078
TI  - [Concern a case of burning of the right hand caused by fluorhydric acid (author's
      transl)].

PMID- 1013079
TI  - [Malignant and benign goiter (author's transl)].

PMID- 1013080
TI  - [Indication for surgery in gastric ulcer (author's transl)].

PMID- 1013081
TI  - [Diagnostic peritoneal tapping and peritoneal lavage in blunt abdominal trauma
      (author's transl)].

PMID- 1013082
TI  - [Single stage and multistage operative procedures in colonic surgery (author's
      transl)].

PMID- 1013083
TI  - [Effectiveness of treating tuberculosis in persons of advanced age].

PMID- 1013084
TI  - [Experience with organization of therapeutic-preventive services to patients with
      tuberculosis of the eyes].

PMID- 1013085
TI  - [Pathogenetic therapy of destructive pulmonary tuberculosis].

PMID- 1013086
TI  - [Clinico-x-ray characteristics of the caverns of patients with newly detected
      pulmonary tuberculosis].

PMID- 1013087
TI  - [Clinical significance of the massiveness of bacillus excretion in chronic
      destructive pulmonary tuberculosis].

PMID- 1013088
TI  - [Disability due to tuberculosis and basic trends toward changes].

PMID- 1013089
TI  - [Diagnosis and treatment of exudative pleuritis of tuberculous etiology].

PMID- 1013090
TI  - [Radical-reconstructive surgery of the thoracic portion of the spine in
      complicated forms of tuberculous spondylitis].

PMID- 1013091
TI  - [Osteochondrosis in abscessing forms of tuberculous spondylitis].

PMID- 1013092
TI  - [Prevention and early detection of osteoarticular tuberculosis].

PMID- 1013093
TI  - [Active detection of early forms of renal tuberculosis].

PMID- 1013094
TI  - [Comparative assessment of radioisotope methods of studying renal tuberculosis].

PMID- 1013095
TI  - [Criteria for the activity and cure of tuberculosis of the skin].

PMID- 1013096
TI  - [Blood and lymph vessel transformation in chronic cor pulmonale].

PMID- 1013097
TI  - [Morphometric aspects of the study of compensated and decompensated cor pulmonale
      in patients with pulmonary tuberculosis].

PMID- 1013098
TI  - [Outpatient care of patients with inactive osteo-articular tuberculosis].

PMID- 1013099
TI  - [Electroencephalographic criteria for disorders in the functional state of the
      central nervous system in pulmonary tuberculosis patients undergoing intensive
      isoniazid therapy].

PMID- 1013100
TI  - [Diagnosis of exudative pleurisy].

PMID- 1013101
TI  - [Epidemiology and clinical picture of tuberculosis in regions of the extreme
      north].

PMID- 1013102
TI  - [Epidemiological significance of patients with chronic forms of pulmonary
      tuberculosis].

PMID- 1013103
TI  - [Changes in the contingent of patients with chronic destructive pulmonary
      tuberculosis over the period of 10 years (according to the materials of the
      Vinnitsa district)].

PMID- 1013104
TI  - [Myocardial function in active pulmonary tuberculosis with concomitant
      arteriosclerosis].

PMID- 1013105
TI  - [Ventilatory and gas-exchange functions of the lungs after recovery from
      tuberculosis].

PMID- 1013106
TI  - [Outcome of tuberculosis depending on roentgenological changes in the lungs
      preceding the disease].

PMID- 1013107
TI  - [Effect of bronchial lesions on the indicators of ventilation and respiratory
      mechanics in pulmonary tuberculosis].

PMID- 1013108
TI  - [Functional euphylline test and its importance in patients clinically cured of
      pulmonary tuberculosis].

PMID- 1013109
TI  - [Residual volume of the lungs as a criterion of functional pathology and
      functional rehabilitation of persons with post-tuberculosis pneumosclerosis].

PMID- 1013110
TI  - [Relationship between the dynamics of systolic phases of the right ventricle and
      the respiratory phases (on the method of bloodless evaluation of hemodynamics in
      the lesser circulation)].

PMID- 1013111
TI  - [Changes of external respiration and cardiac activity under the effect of oxygen
      in patients with pulmonary tuberculosis].

PMID- 1013112
TI  - [State of bronchi in patients with newly detected destructive pulmonary
      tuberculosis].

PMID- 1013113
TI  - [Content of active fraction of HINA in the blood of patients with pulmonary
      tuberculosis and infectious hepatitis during treatment with isoniazid].

PMID- 1013114
TI  - [Ultrasonic test for early diagnosis of a lesion of the organ of hearing].

PMID- 1013115
TI  - [Ambulatory treatment of pulmonary tuberculosis in patients with excessive
      alcohol drinking].

PMID- 1013116
TI  - [High-risk tuberculosis group at an industrial plant].

PMID- 1013117
TI  - [Intracardiac hemodynamics in patients with pulmonary tuberculosis with disorders
      of bronchial patency].

PMID- 1013118
TI  - [Lung volume in bronchial asthma and pulmonary tuberculosis].

PMID- 1013119
TI  - [Paraspecific polyserositis in a patient with active pulmonary tuberculosis].

PMID- 1013120
TI  - [Effect of isoniazid on the distribution of protein-bound iodine in subcellualar
      fractions and organs in experimental studies].

PMID- 1013121
TI  - [Splenic rupture after bronchography].

PMID- 1013122
TI  - Intracerebral haematoma with communicating hydrocephalus in a neonate.

PMID- 1013123
TI  - Myasthenia Gravis.

PMID- 1013124
TI  - Epidermolysis bullosa dystorphica and systemic lupus erythematosus.

PMID- 1013125
TI  - Tuberculous ulceration of the penis.

PMID- 1013126
TI  - Project selection in the pharmaceutical industry.

PMID- 1013127
TI  - Project selection in the pharmaceutical industry.

PMID- 1013128
TI  - Ocular malignant diseases.

PMID- 1013129
TI  - Comparison of iris clip lens. Results with plain intracapsular extraction.

PMID- 1013130
TI  - Cystoid macular oedema.

PMID- 1013132
TI  - The fitting of continuous wear soft contact lenses at the time of cataract
      surgery.

PMID- 1013131
TI  - Anterior chamber implants with the Ridley tripod lens.

PMID- 1013133
TI  - The problem of the class iii malocclusion.
AB  - The etiology and treatment of Class III malocclusion has been discussed. The
      value of electromyographic assessment in the assessment and prediction of Class
      III malocclusion has been shown.

PMID- 1013134
TI  - Bone disease in the elderly.

PMID- 1013135
TI  - The problems of diagnosis of arthritis in the elderly.

PMID- 1013136
TI  - Surgical treatment of ageing joints.

PMID- 1013137
TI  - The management of osteoporosis.

PMID- 1013139
TI  - An epidemiological approach to the monitoring of hospital waiting list
      statistics.

PMID- 1013138
TI  - A cohort study of mortality in relation to lung function.

PMID- 1013140
TI  - Rheumatoid arthritis, vasculitis and pseudolymphoma.

PMID- 1013141
TI  - Congenital abnormality of inferior vena cava, infectious mononucleosis and
      aneurysm of common carotid artery.

PMID- 1013142
TI  - Coeliac disease with Hodgkin's lymphoma.

PMID- 1013143
TI  - Meningococcal septicaemia.

PMID- 1013144
TI  - Medical disease and the anaesthetist.

PMID- 1013145
TI  - A perspective of oral cancer.

PMID- 1013146
TI  - The effect of truncal vagotomy on lower esophageal sphincter pressure and
      response to cholinergic stimulation.

PMID- 1013147
TI  - Calcitonin, serotonin and parafollicular cell granules during the hibernation
      activity cycle in the bat.

PMID- 1013148
TI  - Intrarectal infection of guinea pigs with the agent of guinea pig inclusion
      conjunctivitis.

PMID- 1013149
TI  - Effects of promethazine hydrochloride on the metabolism of rabbit alveolar
      macrophages.

PMID- 1013150
TI  - Tensile properties of tendon in copper-deficient swine.

PMID- 1013151
TI  - Levels and significance of erythrocyte purine enzymes in hyperuricemia.

PMID- 1013152
TI  - Decreased E-rosette formation following streptolysin-O treatment.

PMID- 1013153
TI  - Effects of bradykinin on rat lymphocytes.

PMID- 1013154
TI  - The interrelation of fluoride and iron in anemia.

PMID- 1013155
TI  - Canine cyclic hematopoiesis: platelet size and thrombopoietin level in relation
      to platelet count.

PMID- 1013156
TI  - Long-term persistence of antibody following Enders' original and More attenuated
      live measles virus vaccine.

PMID- 1013157
TI  - Effect of timolol on hydralazine-induced increase in plasma renin activity in
      spontaneously hypertensive and normotensive rats.

PMID- 1013158
TI  - Early change of specific activity of plasma and red blood cell cholesterol
      following intravenous administration of [4(-4)C] cholesterol in man.

PMID- 1013159
TI  - Effects of fructose and other dietary carbohydrates on plasma glucose, insulin
      and lipids in genetically obese (Ob/Ob) mice.

PMID- 1013160
TI  - Appearance of inorganic pyrophosphatase during growth of Streptococcus mutans
      cells.

PMID- 1013161
TI  - Adipocyte size distribution in ob/ob mice during preobese and obese phases of
      development.

PMID- 1013162
TI  - Effects of chlorothiazide on glucose utilization, glycogen content, and lactic
      acid production of aorta.

PMID- 1013163
TI  - Canine pituitary prolactin: isolation and partial characterization.

PMID- 1013164
TI  - Spiculated erythrocytes of cholesterol-fed guinea pigs: changes of morphology,
      composition, and osmotic fragility.

PMID- 1013165
TI  - Effects of corticosterone treatment on puberty in female rats.

PMID- 1013166
TI  - Alterations in thyroidal calcitonin content of rats fed diets of varying Ca:P
      ratios.

PMID- 1013167
TI  - Tropic effect of cholecystokinin-pancreozymin on pancreatic acinar cells from
      rats of different ages.

PMID- 1013168
TI  - Enhanced effect of cyclophosphamide on Burkitt lymphoma cell lines in vivo.

PMID- 1013169
TI  - Effects of angiotensin on drinking.
AB  - A series of four experiments was carried out to assess the effects of angiotensin
      II on drinking elicited by various types of stimulation. Experimental I examined
      the effects of the interaction of 2 cc/kg of 5% NaCl plus 0.2 mg/kg angiotensin
      II on ad lib eating and drinking. Results indicate that NaCl plus angiotensin
      produced an additive enhancement in water consumption. Experiment 2 was conducted
      to investigate the effects of 0.2, 0.4, 0.8, 1.2, and 1.6 mg/kg of angiotensin II
      on drinking and eating in 23 hr water deprived animals. Dose related increases in
      drinking alone were observed. In Experiment 3 the effects of 0.4, 0.8, 1.2, and
      1.6 mg/kg of angiotensin II on schedule dependent lever pressing and schedule
      induced drinking and licking were determined. Results demonstrate that
      angiotensin II decreased lever pressing and increased schedule induced water
      consumption without a concomitant increase in licking. Experimental 4 examined
      the effects of the same doses of angiotensin II on prandal drinking in food
      deprived animals. Under these conditions angiotensin II increased water
      consumption. Results were discussed in terms of the differential effects of
      angiotensin II on drinking, eating, and schedule dependent lever pressing.

PMID- 1013170
TI  - Does the rat with hereditary hypothalamic diabetes insipidus have impaired
      avoidance learning and/or performance?
AB  - Avoidance learning and extinction of rats with hereditary hypothalamic diabetes
      insipidus (Brattleboro strain) were studied in 2 experiments that differed only
      in shock intensity. In both experiments rats homozygous for diabetes insipidus
      were more deficient in both escape and avoidance responding than were their
      heterozygous or normal controls. Although the hterozygous animals showed improved
      escape performance at the higher shock intensity, their avoidance behavior was
      not improved. The superiority of normal and heterozygous animals in extinction
      performance, relative to the homozygous animals, was eliminated or reversed when
      the differences in terminal acquisition performance were taken into account by
      analyses of covariance. Deficiency of ADH, therefore, may not result in faster
      extinction of avoidance behavior.

PMID- 1013171
TI  - Effects of alpha-MSH on motivation, vigilance and brain respiration.
AB  - In a series of experiments designed to assess the effects of alpha-MSH on various
      motivational processes, it was observed that the hormone can slightly decrease
      food intake and increase water consumption during the first hr after
      administration in rats. alpha-MSH also modified avoidance behavior in 1- and 3
      day-old chicks, but there were no reliable effects on activity, distress
      vocalizations and the tonic immobility response. alpha-MSH appeared to modulate
      the sleep-waking activity of rats, and the most prominent effect was an increase
      of slow wave sleep during the 2-3 rd hr after treatment. A possible second effect
      was a homogenization of sleep patterns--with poor sleepers exhibiting increases
      of activated sleep and good sleepers a reduction. Measurement of in vitro brain
      oxygen consumption indicated that mice treated with alpha-MSH exhibit an 18%
      reduction in respiration of the brain stem section which includes the locus
      coeruleus, but did not reliably change respiration in forebrain cortices. alpha
      MSH also produced a modest 14% increase of plasma glucose. These results are
      discussed in terms of possible modulation by alpha-MSH of activity in central
      autonomic cell groups such as the locus coeruleus.

PMID- 1013172
TI  - [The process of decision in the categorical-nosological classification of
      depressives syndromes and its importance for the concept of therapy (author's
      transl)].
AB  - Proceeding from the fact psychiatric thinking is very much based on fixed
      categories we try to study the rigidity of the traditional system of nosological
      classification of the depressive syndromes. Though an increasing number of
      colleagues advocates a multiconditional or complex analysis of depressive states
      in theory and praxis, and in their majority is convinced of an involvement of
      both endogenous and psychogenic factors in most depressions, this conviction
      seems not to influence the use of those traditional categories. A classification
      of endogenous and psychogenic depressions corresponding to the accustomed
      diagnostical schemes is being applied. The general acceptance of this coercion to
      an absolute alternative diagnosis reveals us the reign of traditional categories
      in our mental attitude. Thus, we must aspire to create denotations for a
      nosological main-group of depressive states that will be interpreted multi
      conditional. Such a step would have extensive consequences for our treatment
      concepts. The traditional alternative diagnostics still suggest the possibility
      of an alternative therapy and thus mainly tend to a single-track accentuation in
      either pharmacological or psychological therapy. Provided a better categorial and
      nosological differentiation of the depressive spectrum, the construction of
      integrated plans of therapy could be achieved in a more differentiated and better
      founded way.

PMID- 1013173
TI  - [Basler drug- and alcohol-questionnaire. First experiences in the construction of
      a test instrument for evaluation of dependency of drug-and/or alcohol-consumers
      (author's transl)].
AB  - In order to provide an estimation of the degree of drug and/or alcohol dependency
      the authors designed a questionnaire. In this paper the basic steps of item
      analysis, factor analysis and calculation of reliability (split-half-method) are
      reported. After elimination of 6 items out of 65 the item-metric and factorial
      characteristics as well as the reliability of the instrument could be judged as
      satisfactory. On the item level two factor analytical solutions were interpreted.
      The first one showed one factor covering the general concept of dependency, the
      second one suggested a 3- dimensional differentiation in terms of 1. negative
      self-concept, 2. obsessional traits, and 3. addictive illness behavior.

PMID- 1013174
TI  - [The time-course of alcohol induced changes in self-rating-scales of mood
      (author's transl)].
AB  - Alcohol was administered in a dose of 0.77 g per kg bodyweight to 16 healthy male
      subjects in a cross-over-design. A study was made of a number of psychological
      and physiological variables to determine the modifications that accompany the
      alcohol-induced changes in the orienting response to an auditory stimulus. Five
      determinations were made at intervals following a dose of alcohol and five in a
      control session when no alcohol was given. The results obtained for the
      psychological variables (self-ratings of the intensity of intoxication and the
      degree of being startled by the first stimulus; and self-assessment of mood) show
      alcohol to have stimulant as well as depressant effects. Some of the variables
      show stimulant effects, mainly at the beginning of the absorption phase, whereas
      other variables show depressant effects, both in the absorption phase and the
      postabsorption phase. Changes in physiological variables (such as parameters of
      electrodermal activity and of the heart rate response) support these findings.
      The simultaneous presence of both stimulant and depressant effects is pointed out
      as well as the difficulties in describing these findings in terms of a
      unidimensional model of activation.

PMID- 1013175
TI  - [Attentions, sensumotoric coordination, and angular acceleration threshold under
      the influence of small doses of alcohol in relation to aspects of personality
      (author's transl)].
AB  - In a parallel cross-over design 22 male students were examined with 0,6 g alcohol
      per kg of body weight (0,5 o/oo). The dependent variables were attention,
      sensumotoric coordination angular acceleration threshold, and mood. A number of
      personality trait factors (FPI, MPI, habit of alcohol and tobacco consumption,
      body measures) and state factors (subjective state, psychophysiological state)
      were also measured, others were helf constant (age, sec, intelligence,
      standardisized breakfest, duration of drinking time, day time, week time). The
      accelerated concentration of blood alcohol was connected with neuroticism and
      subjective bad state on day of examination. The accelerated elimination of blood
      alcohol varried with bad subjective state. Attention, and sensumotoric
      coordination were significantly (by a BAC of 0,42 o/oo) diminished and the
      sensitivity of angular acceleration threshold was strongly (by a BAC of 0,30,
      0,44, 0,38 and 0,21 o/oo) diminished, connected with a general brightening of
      mood. Certain personality traits and states may diminish performances with those
      slight doses of alcohol.

PMID- 1013176
TI  - Tissue digoxin concentrations at digoxin intoxication in normal, acutely
      hypokalemic, and acutely hyperglycemic dogs.
AB  - Thirty intact dogs were studied to determine digoxin concentration in various
      tissues after ventricular tachycardia had been induced by digoxin infusion. A
      control group was infused solely with digoxin. A second group was made acutely
      hypokalemic by glucose-insulin infusion before the digoxin infusion. A third
      group was infused with glucose and digoxin to determine the effect of increased
      blood glucose levels and osmalarity on the induction of ventricular tachycardia.
      Results were: (1) The amount of digoxin infused to produce ventricular
      tachycardia did not differ getween the normal and hypokalemic groups. (2) The
      concentration of digoxin in various parts of the heart, other muscle tissue,
      renal cortex, and liver did not differ between the normal and acutely hypokalemic
      dogs although the amount excreted in bile and urine was reduced in hypokalemia.
      (3) Acute hypokalemia did not sensitize the myocardium to the arrhythmogenic
      effects of digoxin. (4) Ventricular tachcardia occurred at a similar plasma
      digoxin level in normal and acutely hypokalemic dogs. (5) In dogs with a lowered
      plasma potassium level, junctional tachycardia occurred whereas it did not occur
      in normal dogs or those with only a high blood glucose level. (6) Ventricular
      tachycardia occurred in the hyperglycemic dogs at a plasma digoxin level of 170
      ng/ml, which was significantly greater than in the other experiments (7) Acute
      hyperglycemia reduced the mean rate of myocaridal uptake of digoxin into atria
      and right and left ventricular tissue; and the concentration of digoxin in atria,
      left ventricle, and interventricular septum was lower at the time of ventricular
      tachycardia than occurred in normal dogs. (8) Lowering the plasma potassium level
      in the presence of acute hyperglycemia, which occurred with the glucose-insulin
      infusion, did increase the myocardial uptake of digoxin. Similar effects of
      hyperglycemia were noted on mean hepatic uptake and excretion of digoxin and also
      the renal uptake of the glycoside.

PMID- 1013177
TI  - Binding of an opiate, levorphanol, to intact neuroblastoma cells in continuous
      culture.
AB  - Mouse neuroblastoma cells in continuous culture, incubated for 1 to 2 days in the
      presence of 10--6 M levorphanol or morphine, were found to become tolerant to and
      dependent on those biologically active opiates. Examination of the interaction
      between levorphanol and the whole neuroblastoma cell suggested that levorphanol
      was binding to stereospecific opiate receptor sites. This binding was time and
      temperature dependent, and saturable at concentrations greater than 10--5 M
      levorphanol. Competition by other opiates for levorphanol sites correlated with
      their biological activity. This is the first evidence for saturable,
      stereospecific opiate binding in a homogeneous population of unhybridized cells
      in continuous culture.

PMID- 1013178
TI  - On the Comorosan effect.
AB  - A possible explanation for the necessary and sufficient irradiation to produce
      the controversial Comorosan effect is discussed. Using a modified quantum theory
      requiring a definition of the relation of four parameters of a light signal
      instead of the usual two, the lack of superposition of irradiating sources is
      accounted for as well as the ineffectiveness of all parts of the total visible
      spectrum. The most effective average wavelength for obtaining the effect is
      unique merely because of the appropriateness of the bandwidth of the filter.
      Changing the filter bandwidth in a way related to a change in the average
      wavelength should produce the effect at other average wavelengths. The storage of
      energy within the irradiated substance is considered to be due to either a
      resonance effect with photon annihilation or a Raman effect with photon
      scattering.

PMID- 1013179
TI  - Antineoplastons: biochemical defense against cancer.

PMID- 1013180
TI  - The relaxation times of water protons and division rate in human breast cancer
      cells: a possible relationship to survival.

PMID- 1013181
TI  - The effect of small quantities of phospholipase C on ionic and protein
      permeabilities of red cell membranes.

PMID- 1013182
TI  - Effects of nasal ZnSO4 irrigation and olfactory bulbectomy on rat pups.

PMID- 1013183
TI  - Different intensities of unsignalled inescapable shock treatments as determinants
      of non-shock-motivated open field behavior: a resolution of disparate results.

PMID- 1013184
TI  - Energetics of meal patterns in rats.

PMID- 1013185
TI  - A preprandial intake pattern in weanling rats ingesting a high fat diet.

PMID- 1013186
TI  - Feeding response to regulatory challenges after 6-hydroxydopamine injection into
      the brain noradrenergic pathways.

PMID- 1013187
TI  - Psychophysiological correlates of tonic immobility in the domestic chicken
      (Gallus gallus).

PMID- 1013188
TI  - Suppression of cricket killing and eating in laboratory mice following lithium
      chloride injections.

PMID- 1013189
TI  - Performance of an instrumental response under conditions of varying cutaneous
      afferent activity levels.

PMID- 1013190
TI  - Mating in male rabbits after anesthesia of the glans penis.

PMID- 1013191
TI  - Some problems on the estimation of water intake by a drinkometer.

PMID- 1013192
TI  - Dietary obesity in adult rats: similarities to hypothalamic and human obesity
      syndromes.

PMID- 1013193
TI  - Preoptic hypernatremic syndrome and the regulation of water balance in the rat.

PMID- 1013194
TI  - Septal lesions and aversive nonreward.

PMID- 1013195
TI  - The reinforcing effects of vagal stimulation on classically conditioned heart
      rate in rats.

PMID- 1013196
TI  - Anatomical and behavioral mapping of rhythmic slow wave activity in rat
      hippocampus.

PMID- 1013197
TI  - Taste of dipeptides.

PMID- 1013198
TI  - Schedule-induced drinking and reinforcement omission.

PMID- 1013199
TI  - Cholecystokinin-induced satiety in weanling rats.

PMID- 1013200
TI  - Castration and amphetamine effects on acquisition of a Sidman avoidance task in
      rats.

PMID- 1013201
TI  - Sex differences in circadian wheel running rhythms in the Mongolian gerbil.

PMID- 1013202
TI  - Effects of water deprivation and prior LiCl exposure in conditioning taste
      aversions.

PMID- 1013203
TI  - Testosterone and fear behavior in male chicks.

PMID- 1013204
TI  - Cortical spreading depression: a case of state dependent learning.

PMID- 1013205
TI  - Penile deafferentation and the effect of mating experience on sexual motivation
      in adult male rats.

PMID- 1013206
TI  - The ingestion of food and the recovery of body weight following fasting in the
      naive rat.

PMID- 1013207
TI  - Partitioning of behavioral arousal.

PMID- 1013208
TI  - Individual differences in the response to androgen in male rabbits.

PMID- 1013209
TI  - Relationship between obesity, weight loss, and taste responsiveness.

PMID- 1013210
TI  - Time-dependent fornix influence on increased light aversion induced by septal
      lesions.

PMID- 1013211
TI  - Unit responses in hypothalamus and mesencephalic reticular formation to acoustic
      stimuli and electrical stimulation of ipsi- and contralateral amygdala.

PMID- 1013212
TI  - Recovery of cortical responses following localized cooling in the thalamus.

PMID- 1013213
TI  - Alternation behavior of cats with medial visual cortex ablation.

PMID- 1013214
TI  - VMH lesions and reactivity to electric footshock in the rat: the effect of early
      testosterone level.

PMID- 1013215
TI  - Plasma hyperosmolality at the onset of drinking during starvation induced
      hypovolemia.

PMID- 1013216
TI  - Effect of medial archistriatal lesions on the conditioned emotional response and
      on auditory discrimination performance of the pigeon.

PMID- 1013217
TI  - Effects of anesthetic injected into brainstem sites on body temperature and
      behavioral thermoregulation.

PMID- 1013218
TI  - Influence of a monotonous food on body weight regulation in humans.

PMID- 1013219
TI  - Pituitary-adrenal activity under different appetitive extinction procedures.

PMID- 1013220
TI  - A quantitative study on interocular transfer in the rabbit.

PMID- 1013221
TI  - A device for increasing the amplitude of the pulse pressure of cerebrospinal
      fluid.

PMID- 1013222
TI  - A simple inexpensive device for rapidly insulating subcortical electrodes.

PMID- 1013223
TI  - Cerebral pulsation and single unit recording in the guinea pig's visual cortex.

PMID- 1013224
TI  - [Attempt of an epidemiological presentation of chronic obstructive bronchitis and
      emphysema in Carinthia (author's transl)].

PMID- 1013225
TI  - [The prevalence of chronic bronchitis in Slovenia (author's transl)].

PMID- 1013226
TI  - [Pathomorphologic reasons for the development of obstructive ventilatory
      disturbances in chronic bronchitis (author's transl)].

PMID- 1013227
TI  - [Immunopathologic aspects of chronic bronchitis (author's transl)].

PMID- 1013228
TI  - [Proteins in the sputum of patients with chronic bronchitis (author's transl)].

PMID- 1013229
TI  - [Cytologic criteria of chronic spastic bronchitis (author's transl)].

PMID- 1013230
TI  - [Chronic nonspecific respiratory syndrome in the functional diagnostics (author's
      transl)].

PMID- 1013231
TI  - [Chronic obstructive bronchitis in shipyard workers (author's transl)].

PMID- 1013232
TI  - [Experiences with the measurement of "closing volume" in healthy subjects and in
      patients with pulmonary disease (author's transl)].

PMID- 1013233
TI  - [Possibilities and limits in the functional diagnosis of chronic bronchitis and
      emphysema (author's transl)].

PMID- 1013234
TI  - [Clinical and pathophysiological characteristics of bronchitic and emphysematous
      type of chronic obstructive pulmonary disease (author's transl)].

PMID- 1013235
TI  - [Chronic bronchitis and intrinsic asthma (correlation of clinical picture and
      reversibility of obstructive ventilatory disturbances (author's transl)].

PMID- 1013236
TI  - [Outpatient medical care of patients with chronic obstructive bronchitis
      (author's transl)].

PMID- 1013237
TI  - [Success of the out-patient treatment of chronic obstructive bronchitis as a
      prevention of recidivation (author's transl)].

PMID- 1013238
TI  - [Methods and criteria for the evaluation of working ability in patients with
      chronic bronchitis (author's transl)].

PMID- 1013239
TI  - [Compulsory hospitalization].

PMID- 1013240
TI  - [Social determinants in the hospitalization of mentally ill].

PMID- 1013241
TI  - [Mental disorders and personality features as related to academic achievements].

PMID- 1013242
TI  - [Construction of a positive appraisal scale for mental state in psychoses].

PMID- 1013243
TI  - [Clinical evaluation of the Honigfeldt and Klett scale (NOSIE-30) to be used by
      the nursing staff in depressive and other psychopathological syndromes].

PMID- 1013244
TI  - [Subdepression: its course, treatment and prognosis].

PMID- 1013245
TI  - [Indications for lithium carbonate prophylaxis].

PMID- 1013246
TI  - [Ambulatory group psychotherapy in the treatment of psychoses].

PMID- 1013247
TI  - [Diagnosis, nomenclature and forensic psychiatry rulings in personality
      disorders].

PMID- 1013248
TI  - [Mental and neurological disorders in chronic mountain sickness].

PMID- 1013249
TI  - [Crime, brutality and aggression on television and the viewer's reactions].

PMID- 1013250
TI  - [Heminevrin abuse by a chronic alcoholic].

PMID- 1013251
TI  - [Early stage of exhibitionism].

PMID- 1013252
TI  - [Treatment of schizophrenia with trifluoperazine].

PMID- 1013253
TI  - Technical eclecticism and open-case consultation: a psychotherapeutic training
      model.

PMID- 1013254
TI  - Psychophysiological changes in feeling therapy.

PMID- 1013255
TI  - Psychology of scientist: XXXIV. MMPI characteristics of physical and social
      science students: replication and reanalysis.

PMID- 1013256
TI  - Relationship between moral development test scores of juvenile delinquents and
      their inclusion in a moral dilemma discussion group.

PMID- 1013257
TI  - Self-actualization, neuroticism, and extraversion revisited.

PMID- 1013258
TI  - Countercontrol in hypnotic control groups.

PMID- 1013259
TI  - Locus of control, anxiety, and cognitive functioning.

PMID- 1013260
TI  - Conceited talk: a test of hypotheses.

PMID- 1013261
TI  - Nonverbal communication and the judgment of leadership.

PMID- 1013262
TI  - Behavior and traditional therapy applied to pedophiliac exhibitionism: a case
      study.

PMID- 1013263
TI  - An initial investigation into the parameters of overcorrection.

PMID- 1013264
TI  - Maintenance of psychophysiological changes in feeling therapy.

PMID- 1013265
TI  - Comments on criminal offenders and the WAIS picture arrangement "hold-up" item.

PMID- 1013266
TI  - Alcohol, field dependence, and dyadic self-disclosure.

PMID- 1013267
TI  - Relationship between paranoid tendencies and projective behavior.

PMID- 1013268
TI  - Use of a cross-over design in testing short-term methylphenidate effects on
      avoidance conditioning.

PMID- 1013269
TI  - Alternate forms for global self-concept and an achievement-related subscale using
      the Brownfain self-rating inventory.

PMID- 1013270
TI  - Educational orientations of faculty: assessing a personality model of the
      academic professions.

PMID- 1013271
TI  - Distractibility, intensity of reaction, and non-nutritive sucking.

PMID- 1013272
TI  - Characteristics of current social stressors.

PMID- 1013273
TI  - Methodological issues in relating, psychiatric symptoms to social stressors.

PMID- 1013274
TI  - Prediction of attrition from a therapeutic community.

PMID- 1013275
TI  - Overcontrolled hostility, empathy, and egocentric balance in violent and
      nonviolent psychiatric offenders.

PMID- 1013276
TI  - Mind-body revisited: every 28 days.

PMID- 1013277
TI  - Personality and motivational factors on an intentional-incidental learning task.

PMID- 1013278
TI  - Worry and emotionality components of test anxiety in different sex and age groups
      of elementary school children.

PMID- 1013279
TI  - Effects of alcohol on specific and environmental fear.

PMID- 1013280
TI  - Selective interference during the retrieval of visual images.

PMID- 1013281
TI  - Interference in colour-contingent motion after-effects.

PMID- 1013282
TI  - Two parameters measure apparent change during repetitive stimulation.

PMID- 1013283
TI  - The retrieval hypothesis as an explanation of induced retrograde amnesia.

PMID- 1013284
TI  - Hemispheric differences in processing visual patterns.

PMID- 1013285
TI  - Delayed one-trial extinction of the McCollough effect.

PMID- 1013286
TI  - Kinetics of channel gating in excitable membranes.

PMID- 1013287
TI  - Conformational theory applied to polysaccharide structure.

PMID- 1013288
TI  - Leukemia and the reducing property of viruses.
AB  - Investigations of native blood of healthy people and of patients with acute
      leukemia have shown that the disease might be caused by a strongly reducing
      substance, which is presumably a virus. Evidence for this conclusion was obtained
      mainly by electron spin resonance (ESR) studies and by the determination of the
      catalase activity. ESR spectra of leukemic blood revealed an additional signal
      not present in spectra of healthy blood. Investigation of different blood
      fractions has shown that this signal is caused by a species present in the
      leukocytes only. Addition of reduced glutathione to healthy blood immediately
      after blood drawing resulted in the same signal. On the contrary, oxidizing
      substances, such as oxidized glutathione and KMnO4, added to the blood of
      leukemic patients immediately after its drawing, caused a disappearance of this
      signal depending on the concentration. Since the strongly reducing substances
      causes a reduction in the concentration of the oxidizing substances in biological
      systems, the H2O2 levels should be also affected and, thus, the catalase
      activity, too. As expected, the activity of this enzyme in the leukemic blood
      seems to be considerably lower than in healthy blood.

PMID- 1013289
TI  - Comparison of X-ray and gamma-ray dose-response curves for pink somatic mutations
      in Tradescantia clone 02.
AB  - Microdosimetric data indicate that the mean specific energy, eta, produced by
      individual charged particles from X-rays and gamma rays is different for the two
      radiation qualities by nearly a factor of two. In order to test whether this
      influences the initial, linear component in the dose-effect relations, a
      comparison was made between dose-response curves for pink somatic mutations in
      Tradescantia clone 02 stamen hairs following X and gamma irradiations. Absorbed
      doses ranged from 2.66 to 300 rad.The results are in agreement with predictions
      made on the basis of microdosimetric data. At low doses gamma rays are
      substantially less effective than X-rays. The RBE of gamma rays vs. X-rays at low
      doses was approximately 0.6, a value lower than those usually reported in other
      experimental systems.

PMID- 1013290
TI  - Nuclear energy: health impact of carbon-14.
AB  - Estimates are presented on the carbon-14 generation rates in several reactor
      types and in peaceful nuclear explosions. If the carbon-14 generated in light
      water reactors is released, the population radiation dose rate it causes
      initially will be comparable to that resulting from the krypton-85 and tritium
      generated in these reactors. Because of the long half-life, the radiation dose
      commitment and the dose rate resulting from the environmental build-up of carbon
      14 are considerably larger than those of the two other radionuclides.

PMID- 1013291
TI  - [Biophysical questions in ecology and environmental research. Part 1: An analysis
      of intelligence vs biomass development in humans (author's transl)].
AB  - A first analysis of intelligence vs. biomass development in humans shows that the
      increase of speed to accept new inventions appears not to keep pace with
      exploding population size. It is suggested to assess more accurately the
      "collective intelligence" of the human race, an attempt probably useful for
      several purposes. An equation is presented and used to calculate an upper human
      population limit for the world suggested by the present intelligence level. The
      equation suggests 1.5--2.3 billion people educated to the level of industrialized
      nations. The equation predicts acceptance times for innovations during the early
      evolution of mankind in the order of 10(6) years. Such a time span seems to be in
      accordance with archaeological findings for the acceptance of fire as a common
      tool.

PMID- 1013292
TI  - Biophysical questions in ecology and environmental research. Part 2: The extremes
      of an ecosystem (author's transl).
AB  - Some basic differences and developmental aspects of ecosystems are demonstrated.
      Maximum "energy conductivity" and the pathways of energy flow through ecosystems
      are discussed as the force, potential, or principle to drive the evolution of the
      system. A working hypothesis is offered: Ecosystems maximize the total energy
      flow to optimize temperature stability. The paper stresses in general the need
      and search for new approaches to analyze the evolution of ecosystems. The
      hypothesis presented in this paper should be regarded as stimulation for further
      research.

PMID- 1013293
TI  - [Basic principles of the structuro-metabolic theory in radiobiology].

PMID- 1013294
TI  - [DNA repair, change in DNA-polymerase and DNA-ligase activity of regenerating
      liver in gamma-irradiated rats].

PMID- 1013295
TI  - [Transcription in thymus cells of rats subjected to x-irradiation. 2. Effect of
      exogenous deoxyribonucleic acids on hybridization of nuclear RNA with repeating
      and unique DNA sequences].

PMID- 1013296
TI  - [Effect of ionizing radiation on the activity of components of the DNAase I-
      natural inhibitor of DNA-ase I system in the serum of white rats].

PMID- 1013297
TI  - [Effect of DNA on incorporation of H3-thymidine in bone marrow cells of
      irradiated rats].

PMID- 1013298
TI  - [Post-radiation restoration of DPN and PDN concentrations in different rat
      tissues following acute irradiation and administration of high-polymer DNA].

PMID- 1013299
TI  - [Changes in the concentration of deoxyribonucleoprotein in the spleen and thymus
      of rats subjected to chronic gamma-irradiation].

PMID- 1013300
TI  - [Liver mitochondrial chemiluminescence of rats irradiated with fast neutrons].

PMID- 1013301
TI  - [Restoration of the quantity of colony forming units in the bone marrow and
      spleen of irradiated mice treated with DNA].

PMID- 1013302
TI  - [Effect of several biologically active preparations on a population of the stem
      cell fraction and on the viability of irradiated mice].

PMID- 1013303
TI  - [Antioxidative activity of lipids and radiosensitivity. 3. Effect of directed
      changes in the antioxidative activity of lipids on the radioresistance of mice
      following administration of synthetic antioxidants].

PMID- 1013304
TI  - [Role of the kidney in acute radiation disease].

PMID- 1013305
TI  - [Comparative measurement of the strength of the absorbed dose of mixed gamma
      neutron radiation in biological channel reactor BBP-M].

PMID- 1013306
TI  - [Molecular mechanism stimulating the action of ionizing radiation on seeds. 2.
      Activation of protein and high-molecular RNA synthesis].

PMID- 1013307
TI  - [Molecular mechanisms stimulating the action of ionizing radiation on seeds. 3.
      Role of radiotoxins in stimulating the development of irradiated seeds].

PMID- 1013308
TI  - [Changes in permeability and labeled thymidine incorporation into DNA in a
      culture of Chinese hamster cells exposed to MEA and low temperatures].

PMID- 1013309
TI  - [Effect of radiation on biosynthesis of hemoglobin and its individual
      electrophoretic fractions].

PMID- 1013310
TI  - [Dynamics of several conjugated enzymes of aminonitrogen metabolism in the liver
      of an irradiated animal].

PMID- 1013311
TI  - [Concentration of phenol and quinoid compounds in plants differing in
      radiosensitivity].

PMID- 1013312
TI  - [Frequency of chromosome aberrations in sex cells of mice chronically exposed to
      gamma rays in small doses].

PMID- 1013313
TI  - [Changes in the lymphoid population of the bone marrow under the influence of
      radiomimetics].

PMID- 1013314
TI  - [Radioprotective effect of liposomes containing serotonin].

PMID- 1013315
TI  - [Stimulation of conidial sprouting by Aspergillus niger--a citric acid producer
      under the influence of mutagenic factors].

PMID- 1013316
TI  - [Relationship between the death of mice and parameters of fractionated
      irradiation].

PMID- 1013317
TI  - [Relationship between the response of the pituitary--adrenal cortex system under
      the influence of small doses of ionizing radiation].

PMID- 1013318
TI  - [Effect of gamma-rays on respiration and growth of perilla plants].

PMID- 1013319
TI  - [Accumulation of lead-210 by fresh-water plants].

PMID- 1013320
TI  - [Dose distribution by LET after phantom irradiation with fast neutrons].

PMID- 1013321
TI  - [Radiological diagnosis of disturbances of the respiratory function (author's
      transl)].

PMID- 1013322
TI  - [Angiographic results in chronic osteomyelitis of the lower extremities (author's
      transl)].

PMID- 1013323
TI  - [On the differential diagnosis of multiple skeletal trauma in childhood (author's
      transl)].

PMID- 1013324
TI  - [On mutilating changes in increasingly chronic polyarthritis (rheumatoid
      arthritis) (author's transl)].

PMID- 1013325
TI  - [Skeletal and soft-tissue changes in dialysis patients (author's transl)].

PMID- 1013326
TI  - [On the radiological diagnosis of chronic unspecific ulcerative colitis (author's
      transl)].

PMID- 1013327
TI  - [Condition of urinary system in patients with uterine syndrome (author's
      transl)].

PMID- 1013328
TI  - [On hepatotoxicity of hepatotropic contrast media (author's transl)].

PMID- 1013329
TI  - [Initial experiences with the Soviet ERGA-MP electroroentgenographic apparatus].

PMID- 1013330
TI  - [Sequential scintigraphy and x-ray diagnosis in renal hypertension].

PMID- 1013331
TI  - [On the determination of modulation transfer function in tomography (author's
      transl)].

PMID- 1013332
TI  - [Measuring protocol for aerial dose measurements around stationary medical x-ray
      installations (author's transl)].

PMID- 1013333
TI  - [Controlled area for mobile medical x-ray equipment (author's transl)].

PMID- 1013334
TI  - Molecular neuropathology.

PMID- 1013335
TI  - Neurosecretion -- comparative and evolutionary aspects.

PMID- 1013336
TI  - Hormones and brain development.

PMID- 1013337
TI  - Vasopressin and memory consolidation.

PMID- 1013338
TI  - Real neural networks.

PMID- 1013339
TI  - The nerve growth factor: its role in growth, differentiation and function of the
      sympathetic adrenergic neuron.

PMID- 1013340
TI  - Neuronal circuitry and its development.

PMID- 1013341
TI  - Models of neuronal populations: the basic mechanisms of rhythmicity.

PMID- 1013342
TI  - A glance at some problems facing brain research today.

PMID- 1013343
TI  - Organization of spontaneous electrical activity in the neocortex.

PMID- 1013344
TI  - Plasticity in the adult mammalian central nervous system.

PMID- 1013345
TI  - Are invertebrate nervous systems good models for the functional organization of
      the brain?

PMID- 1013346
TI  - EEG and behavior.

PMID- 1013347
TI  - On drive, conflict and instinct, and the functional organization of behavior.

PMID- 1013349
TI  - The brain as a functional entity.

PMID- 1013348
TI  - Tissue fractionation methods in brain research.

PMID- 1013350
TI  - A unifying approach to mind and brain: ten year perspective.

PMID- 1013351
TI  - The nature of consciousness: some persistent conceptual difficulties and a
      practical suggestion.

PMID- 1013352
TI  - Functional biochemistry of neurons and glial cells.

PMID- 1013354
TI  - Industrial research in the quest for new medicines.

PMID- 1013353
TI  - Plastic changes of neurons during acquisition of new behavior as a problem of
      protein differentiation.

PMID- 1013355
TI  - Changing influences on goals and incentives in drug research and development.

PMID- 1013356
TI  - Problems of medical practice and of medical- pharmaceutical research.

PMID- 1013357
TI  - [Clinical picture of hepatitis B in patients over the age of 60].

PMID- 1013358
TI  - [Chronic hepatitis B. I. Symptomatology and factors favoring transition from the
      acute to the chronic form].

PMID- 1013359
TI  - [Characterization of Yersinia pseudotuberculosis strains isolated in Poland in
      the years 1968-1975].

PMID- 1013360
TI  - [Epidemiological situation prevailing at the UN Emergency Forces in Egypt in the
      1st half of 1975].

PMID- 1013361
TI  - [Epidemiology of neurologic diseases in Poland. II. Sex, age and diagnosis].

PMID- 1013362
TI  - [Work incapacity caused by respiratory disease in relation to smoking habits and
      symptoms of chronic bronchitis].

PMID- 1013363
TI  - [Case of rabies without hydrophobia in a human].

PMID- 1013364
TI  - [Global program for smallpox eradication based on our epidemiological experience
      in India].

PMID- 1013365
TI  - [Leptospirosis outbreak in the Wroclaw Province in 1974].

PMID- 1013366
TI  - [Choriomeningitis virus as etiologic agent of neuroinfections in Poland].

PMID- 1013367
TI  - [Occurrence of Salmonella in feces of wild birds in Poland].

PMID- 1013368
TI  - [Epidemiology of neurologic diseases in Poland. Correlation between morbidity,
      incidence and recording rate of neurologic diseases].

PMID- 1013369
TI  - [Cobalt-activated acylase activity test as applied in the diagnosis of viral
      hepatitis].

PMID- 1013370
TI  - [Psychoanalysis and truth].

PMID- 1013371
TI  - [Psychoanalytic examination of functionally sterile couples].

PMID- 1013372
TI  - [The classical and ego-psychological theory of depression].

PMID- 1013373
TI  - [Typical differences between Swiss and southern Germans of the educated lower
      middle class].

PMID- 1013374
TI  - [Metapsychology as hermeneutic organon].

PMID- 1013376
TI  - [Mother-infant observation in the teaching of psychoanalysis].

PMID- 1013375
TI  - [The consensus problem in psychoanalysis].

PMID- 1013377
TI  - [Neutralization and sublimation. Observations of young children].

PMID- 1013378
TI  - [Little-known osseous changes of periosteal reaction type in long bones of
      leprotics (author's transl)].

PMID- 1013379
TI  - [Malpractice in the light of the Supreme Court's jurisdiction (author's transl)].

PMID- 1013380
TI  - [Practical value of carcino-embryonic antigen determination in patients with
      cancer of the large intestine (author's transl)].

PMID- 1013381
TI  - [Disturbances of lipid content of red blood cells in renal diseases (author's
      transl)].

PMID- 1013382
TI  - [Problems connected with treatment of arterial hypertension in patients after 60
      years of age (author's transl)].

PMID- 1013383
TI  - [Assessment of the gluconeogenetic function of the liver on the basis of blood
      lactate elimination in patients with acute and chronic liver damage (author's
      transl)].

PMID- 1013384
TI  - [Chronopharmacology (author's transl)].

PMID- 1013385
TI  - [Postgraduate teaching. Lipoprotein metabolism--its physiological and clinical
      aspects. Dyslipoproteinemia in the course of liver diseases].

PMID- 1013386
TI  - [Paraneoplastic syndromes].

PMID- 1013387
TI  - [Effect of trimetoprim, sulfametoxazole and septrin on bacteria cultures obtained
      from patients with infections of urogenital system (authors transl)].

PMID- 1013388
TI  - [Reflection of particular synoptic weather situations in an analysis of Ambulance
      Service calls (authors transl)].

PMID- 1013389
TI  - [The effect of influenza virus infection of pregnant and parturient women on
      their newborns (authors transl)].

PMID- 1013390
TI  - [Lysosomal acid phosphatase of lymphocytes in patients with cancer of the larynx
      (authors transl)].

PMID- 1013391
TI  - [Postgrauduate education. Lipoprotein distribution and its physiological and
      clinical aspects. Role of cholesterol in the development of atherosclerosis].

PMID- 1013392
TI  - [Postgraduate education. Lipoprotein distribution and its physiological and
      clinical aspects. Cholesterol metabolism disorders in their role in human
      pathology].

PMID- 1013393
TI  - [Postgraudate education. Lipoprotein distribution and its physiological and
      clinical aspects. Free fatty acids, their determination and role inthe body].

PMID- 1013394
TI  - [Postgrauduate education. Lipoprotein distribution and its physiological and
      clinical aspects. Phospholipid metabolism disorders and their role in pathology].

PMID- 1013395
TI  - [Nonspecific intestinal ulcer complicated by performation (authors transl)].

PMID- 1013396
TI  - [A case of reciprocal rhythm of A-V nodal origin (authors transl)].

PMID- 1013397
TI  - [Bacterial flora of the vagina before and after treatment of the so called
      "erosion" of vaginal part of uterus with vagothyl (author's transl)].

PMID- 1013398
TI  - [X-ray study of the posterior urethra].

PMID- 1013399
TI  - [Renal pseudotumors].

PMID- 1013400
TI  - [Renal scintscanning].

PMID- 1013402
TI  - [Considerations about the origin levels of the cranial thyroid artery in guinea
      pig (Cavia porcellus)].
AB  - This paper deals with the stablishment of the origin of seven different levels of
      guinea pig cranial thyroid artery, based upon the cartilage of larynx and
      tracheal rings. Forty-five animals (females) from the Faculadade de Ciencias
      Medicas e Biologicas de Botucatu, were anesthetized with chloroform, injected
      with contrasting substance in the thoracic aorta and dissected throught
      stereoscopic microscope. The results were expressed in relative percentage
      figures.

PMID- 1013401
TI  - Lethal effect of the serotonin-xylocaineR association in ganglion-blocked rats.
AB  - In rats anestetized with urethane and under ganglionic blockade by hexamethonium
      (20 mg/kg, i.v.), the i.v. injection of serotonin (60 mug/kg) determined apnea,
      ECG alterations and a brief hypotensive response which is similar to that as
      elicited when 5-HT is given to intact rats. During the hypertension which follows
      that initial response, apnea is still present along with more severe ECG changes.
      After that, blood pressure falls into a prolonged hypotension, which is
      invariably accompanied by death. Neither norepinephrine, nor respiratory
      analeptics (CoramineR, RemeflinF) were able to prevent the fatal outcome. Only
      artificial respiration was found to be useful in some instances. It was concluded
      that the association serotonin plus lidocaine becomes lethal when given to
      ganglion-blocked rate, and this toxic effect can be ascribed mainly to the
      respiratory depressor activity of the drugs.

PMID- 1013403
TI  - [Cerebellum of birds: comparative study of the density of the Purkinje cells in
      the anterior lobe (author's transl)].
AB  - The mean linear density of the Purkinje cells in the anterior lobe of the
      cerebellum of the dung cook, Gallus gallus, is significantly higher (16.8
      cells/mm) than that observed in the anterior lobe of the cerebellum of the black
      vulture, Coragyps atratus (12 cells/mm). It is formulated the hypothesis that
      this quantitative difference is concerned with the type of locomotion, the walk,
      predominant in the dung cook.

PMID- 1013404
TI  - Hepatitis-B antigen in an isolated Indian population (Yanomama indians) Southern
      Venezuela.
AB  - A high frequency of Hepatitis-B antigen (7%) was found in apparently healthy
      Yanomama indians living in southern Venezuela. The prevalence in 24 different
      Yanomama villages varied between 0 and 30%, but only 3 of 938 serum samples
      showed presence of HB-Ab. The distribution of the HB-Ag was found to be
      significantly higher in males than in females.

PMID- 1013405
TI  - Aspects of mitochondrial activity in the estuarine bivalves Crassostrea
      rhizophorae and Lucina pectinatus: a comparative approach.
AB  - In identical laboratory conditions, some differences in the endogenous relative
      activity (mul O2/mg protein/ml/h) were determined by the addition of succinate
      and alpha-keto-glutarate to the mitochondrial-rich-fraction from heart and both
      parts of the adductor muscle in oyster (Crassostrea rhizophorae) and from heart
      and adductor muscle in clams (Lucina pectinatus).

PMID- 1013406
TI  - [Influence of calcium and potassium ions on the parasympathetic stimulation
      secretory response of the isolated and perfused submandibular gland (author's
      transl)].
AB  - The effects of the submandibular gland perfusion with blood, Tyrode's solution,
      Tyrode's solution without calcium, and Tyrode's solution without potassium were
      studied. The effects on sodium, potassium, and calcium concentration in the
      saliva were studied in 11 dogs during electrical stimulation of the chorda
      tympani nerve. According to the statistical analysis we assume that: 1) the
      perfusion of the salivary gland with blood or Tyrode's solution does not alter
      sodium, potassium, and calcium concentration in the saliva; 2) the salivary
      perfusion with calcium free Tyrode's solution does not alter the chemical
      composition of the saliva; 3) the perfusion of the salivary gland with potassium
      free Tyrode's solution produce a decrease of the concentration of this ion in the
      saliva composition.

PMID- 1013407
TI  - Detection of haemoglobin D Punjab in patient with Sydenham's chorea.
AB  - In the present report the authors identified a rare haemoglobin, Hb D Punjab, in
      association with Sydenham's Chorea. They emphasize the importance of
      characterizing unusual haemoglobins by peptide mapping, particularly when the
      electrophoretic pattern shows the characteristics of known haemoglobins and when
      associated with pathologic states.

PMID- 1013408
TI  - The defect in pulmonary gas transfer in patients with sickle cell disease.
AB  - Nine patients with sickle cell disease and without concomitant cardiopulmonary
      illness or acute problems were studied with lung function tests. Besides arterial
      hemoglobin unsaturation, found in all cases so studied, a slight decrease in PaO2
      was also present. The pulmonary gas transfer defect was studied and found to be
      due mostly to increased right to left shunting, although uneven
      ventilation/perfusion relationships seem to have been a factor in a few cases.
      Our data clearly show that the diffusion was not implicated in the gas transfer
      defect. The clinical implications of this little studied and less mentioned
      respiratory defect are discussed. Since the defect may enhance the risk of
      sickling crises, it should be measured in each individual patient, for
      appropriate prophylactic measures. After accidents, pre and post-operatively and
      during acute respiratory illness, the defect should be again reevaluated. In all
      probability many patients will be discovered who represent a respiratory risk,
      and may require special immunizations, prophylactic antibiotics, professional
      relocation and, during emergencies, intensive respiratory care.

PMID- 1013409
TI  - [Nutritive value of macacar bean (Vigna unguiculatta L.) Walp (author's transl)].
AB  - The biological value of dry and immature macacar bean (Vigna unguiculatta L.)
      Walp, isolated or associated to manioc flour, was studied. Thirty-six male Albino
      rats, Wistar strain, aged 23 days, were divided into six groups and fed
      experimental and control (casein) diets for 28 days. The weight curve and the PER
      of the animals fed dry and immature macacar bean either isolated or associated to
      manioc flour were lower than those of the casein group. The data lead to the
      conclusion that the macacar bean is to be used as a food supplement only, due to
      its low biological value.

PMID- 1013410
TI  - The classification of non-Hodgkin's lymphomas.

PMID- 1013411
TI  - [Hydatidiform mole. Clinical review].

PMID- 1013412
TI  - [Feminizing funtional tumors of the ovary].

PMID- 1013413
TI  - [Evolution of various underlined statistics in the San Camilo Maternity Hospital
      at San Felipe].

PMID- 1013414
TI  - [Simultaneous extra- and intra-uterine pregnancy].

PMID- 1013415
TI  - [Simultaneous ectopic and intrauterine pregnancy].

PMID- 1013416
TI  - [Ovarian dysgerminoma].

PMID- 1013417
TI  - [Effect of radiation on cervical smears].

PMID- 1013418
TI  - [Colposcopy in patients with positive or doubtful cytology].

PMID- 1013419
TI  - [Contribution of cytology to intraoperative diagnosis].

PMID- 1013420
TI  - [Value of the cytology of the amniotic fluid as an index of the determination of
      the gestational age].

PMID- 1013421
TI  - [Determination of prenatal sex in cells of the amniotic fluid].

PMID- 1013422
TI  - [Prenatal diagnostic of fetal sex by means of the study of cellular basophils in
      the amniotic fluid. Preliminar report].

PMID- 1013423
TI  - [Prenatal diagnosis of probable heterochromosomic abberrations by means of X and
      Y chromatin study by a complementary technic].

PMID- 1013424
TI  - [Experience with cytohormonal studies in Valparaiso].

PMID- 1013425
TI  - [Cytology of genital herpes].

PMID- 1013426
TI  - [Gynecological cytopathology].

PMID- 1013427
TI  - [Evaluation of the control program of cervicouterine cancer in Arica, 1969-1975].

PMID- 1013428
TI  - [Regional program of early detection of cervicouterine cancer in the Serena].

PMID- 1013429
TI  - [Evaluation of the program of cervicouterine cancer detection in the 5th region].

PMID- 1013430
TI  - [Evaluation of the program of the early detection of cancer in the Northern area
      of Santiago].

PMID- 1013431
TI  - [Analysis of the control program of cervicouterine cancer in the southern region
      of Santiago-Chile, 1974].

PMID- 1013432
TI  - [Organization, development and evaluation of a control program of cervicouterine
      cancer in the Western region of Santiago].

PMID- 1013433
TI  - [Evaluation of the program of early detection of cervicouterine cancer in the
      central region of Santiago during 1974].

PMID- 1013434
TI  - [Evaluation of the program of early detection of cervicouterine cancer in the
      Western region of Santiago during 1974].

PMID- 1013435
TI  - [Program of detection and control of cervicouterine cancer in the 9th region,
      Malleco-Cautin].

PMID- 1013436
TI  - [Evaluation of a program of early detection of cervicouterine cancer in the 11th
      region].

PMID- 1013437
TI  - [Cervicouterine cancer. Responsibilities of the health care team?].

PMID- 1013438
TI  - [Significance of endometrial cells in cervical smears in relation to the use of
      intrauterine devices].

PMID- 1013439
TI  - [Relation between cervical smears and endometrial biopsy in proliferative lesions
      of the endometrium].

PMID- 1013440
TI  - [Intrahepatic cholestasis of pregnancy].

PMID- 1013441
TI  - [Current terminology and nomenclature in vulvar pathology. Histopathological and
      clinical approach].

PMID- 1013442
TI  - [Endotoxic shock in obstetrics].

PMID- 1013443
TI  - [Management of endotoxic shock in abortion].

PMID- 1013444
TI  - [Ovarian disgerminoma in adolescence].

PMID- 1013445
TI  - [Pregnancy in primary sterility caused by peritoneal factors].

PMID- 1013446
TI  - [Typhic abscess of the ovary].

PMID- 1013447
TI  - [2 clinical cases of fetal monsters (thoracopagus)].

PMID- 1013448
TI  - [Renal hydatidosis. Review of the Spanish literature].

PMID- 1013449
TI  - [Familial myopathies (D.M.). Electroclinical study].

PMID- 1013450
TI  - [Trichinosis in the High Hurdes].

PMID- 1013451
TI  - [Immunological and endocrine aspects of neuroblastoma].

PMID- 1013452
TI  - [Electrocardiographic disorders induced by thioridazine poisoning. Apropos of 2
      cases of acute poisoning].

PMID- 1013453
TI  - [Hepatolemticular degeneration (Wison's disease): prolonged treatment with D
      penicillamine in 3 cases].

PMID- 1013454
TI  - [Chronic lymphocytic leukemia: classification of clinical conditions in out
      patients].

PMID- 1013455
TI  - [Prinzmetal's angina. Unusual characteristics].

PMID- 1013456
TI  - [Renal hydatidosis. Apropos of an observation].

PMID- 1013457
TI  - [Right bundle-branch block and electrical alternans after provoking the
      therapeutic immerson reflex (diving reflex)].

PMID- 1013458
TI  - [Hepatitis induced by methyldopa. Actualization with reference to a case].

PMID- 1013459
TI  - [Homocystinuria].

PMID- 1013460
TI  - [The problem of giant gastric ulcer].

PMID- 1013461
TI  - [Syndrome of inadequate vasopressin secretion appearing in a hypothyroideal
      patient during the course of a bronchopneumonia].

PMID- 1013462
TI  - [Effect of beclomethasone dipropionate in aerosol form on the suprarenal function
      in asthmatic patients under prolonged treatment].

PMID- 1013463
TI  - [Anatomo-clinical study of thyroid gland pathology from surgical cases treated at
      the Hospital Insular during 1974-75].

PMID- 1013464
TI  - [Thymoma, selective erythroblastopenia and cellular immunodeficiency. Apropos of
      2 cases].

PMID- 1013465
TI  - [Auricular sinchronic pacemaker. Long term observations].

PMID- 1013466
TI  - [Auricular sinchronic pacemaker. Study of the ventricular function by
      phonomechanocardiography].

PMID- 1013467
TI  - [Lingual thyroid associated to oligomeganephrotic renal hypoplasia].

PMID- 1013468
TI  - [Average of mortality, a demographic indicator of life style].

PMID- 1013469
TI  - [Current problem of venereal diseases].

PMID- 1013471
TI  - [Correlation and regression between percentage of population and mortality of
      minors under age 5].

PMID- 1013470
TI  - [Mycetoma caused by Nocardia. A clinical and mycological case and treatment by
      auserioclysis].

PMID- 1013472
TI  - [Study of the quality of water of the Yaguchi river].

PMID- 1013473
TI  - [Serologic study of bovine brucellosis in Dakar slaughterhouses].

PMID- 1013474
TI  - [Pathogenesis of bovine pleuropneumonia. Receptive state of cattle maintained on
      heparin].

PMID- 1013475
TI  - [2 cases of feline haemobartonellosis observed in Chad].

PMID- 1013476
TI  - [Ecology of Glossina palpalis gambiensis Vanderplank, 1949].

PMID- 1013477
TI  - [Description of Rhipicephalus bergeoni n. sp. (Acarina, Ixodida) of the mountains
      of Ethiopia].

PMID- 1013478
TI  - [Tropical bovine nutrition under extensive Sahelian range conditions: measurement
      of intake and estimation of digestibility and feed value of forages. I:
      Theoretical basis, objectives and methods].

PMID- 1013479
TI  - [Brachiaria brizantha. Best fallow time].

PMID- 1013480
TI  - [Value of the EEG in the detection of tumors of the cerebral hemispheres in
      adults].

PMID- 1013481
TI  - [Detection of cerebral tumors: value of the EEG].

PMID- 1013482
TI  - [Usefulness of the EEG in the diagnosis of cerebral tumors in a regional hospital
      center].

PMID- 1013483
TI  - [Contribution of the EEG to the detection of expansive lesional processes in a
      psychiatric setting].

PMID- 1013484
TI  - [Long-standing epilepsy and cerebral tumors].

PMID- 1013485
TI  - [The normal electroencephalogram. Apropos of 1,000 intracranial tumors].

PMID- 1013486
TI  - [The EEG in the detection of cerebral tumors in children].

PMID- 1013487
TI  - [Value of the EEG in supratentorial tumors in children].

PMID- 1013488
TI  - [Reflections on the electroencephalographic semiology of cerebral tumors].

PMID- 1013489
TI  - [New technic of cerebral function examination: centimetric ultrasound recording
      of cerebral pulsativity. Application to the diagnosis of intracranial tumors].

PMID- 1013490
TI  - [Tumor localization by spectral analysis and its statistical data].

PMID- 1013491
TI  - [The electroencephalogram and the gamma encephalography in the detection of space
      occupying intracerebral lesions].

PMID- 1013492
TI  - [Comparative value of electroencephalography and computerized axial tomography in
      the diagnosis of cerebral tumors].

PMID- 1013493
TI  - [Transverse axial encephalotomography and EEG in cerebral tumors].

PMID- 1013494
TI  - [Comparison of EEG isotope and neuroradiologic results in 85 hemispheric tumors.
      Longitudinal study].

PMID- 1013495
TI  - [Value of the EEG in detecting postoperative sequelae of cerebral tumors].

PMID- 1013496
TI  - [Electro-clinical elements in the diagnosis of recurrence of meningiomas].

PMID- 1013497
TI  - [A case of craniopharyngioma with periodic paroxysmal EEG features].

PMID- 1013498
TI  - Laboratory models of minimal residual cancer; development and preliminary
      immunotherapy studies.
AB  - It is the author's contention that if we wish to investigate immunotherapy for
      cancer in laboratory models, the model must reproduce or at least mimic the
      biological conditions which are encountered in clinical oncologic practice. The
      usual experimental animal tumor systems do not satisfy this requirement. They are
      usually studied as primary transplants of rapidly progressive tumors which kill
      in a few weeks, and experimental treatments are usually started within a day of
      two after implantation, before the tumor is detectable by ordinary methods of
      examination. In clinical oncology the existence of cancer is seldom suspected
      until it reaches a clinically detectable mass, and it is then treated by various
      established methods which, if not curative, at least reduce tumor mass
      temporarily before the tumor recurs locally or at distant sites. A cancer
      patient, therefore, has a rather prolonged exposure to his tumor and an
      opportunity to develop immune and other biological responses to it. Present
      animal models are therefore inadequate for immunotherapy research. This paper
      examines the prerequisites for more accetable experimental tumor models for
      immunotherapeutic research, describes a step-by-step investigation leading to the
      development of what to seems to be more appropriate models, and describes
      preliminary immunotherapy studies in one of the models, in which parabiosis is
      used as a means of transfering antitumor resistance to the "patients" from
      specificially immunized donors.

PMID- 1013499
TI  - Surgical treatment of solitary bone cysts.
AB  - A special method of subperiosteal segmental resection is described as an
      operative treatment for solitary bone cysts in long bones. This procedure
      exploits the high osteogenetic potency of the periosteum in adolescence. An
      autogenous or homologous fibula bone graft locked between the ends of the cyst
      serves to maintain the length of the bone fragments and acts as a guiding rod for
      continued subperiosteal new bone formation. There is full reconstruction of bone
      stability and function at both the cyst region and the donor region (fibula).

PMID- 1013500
TI  - Giant-cell tumor and chondrosarcomas: grading, treatment and results (studies of
      209 and 131 cases).
AB  - The Author reviews 209 cases of giant-cell tumor (follow-up 3-42 years in 130
      cases) and 131 chondrosarcomas (70 central, 50 peripheral, 11 periosteal; follow
      up 10-32 years in 63 cases). Giant-cell tumors are graded into three radiographic
      types (calm, active, aggressive) and three histologic types (typical, aggressive,
      sarcoma). Chondrosarcomas were also graded into three radiographic and three
      histologic types (grades I, II, III). Incidence and mutual relationships of
      radiographic and histologic grades are presented. In recurrences it is possible
      to observe a progression of malignancy in giant-cell tumor and - more often - in
      chondrosarcomas. Results are related to the radiographic and histologic grading
      and to the type of treatment. Indications for treatment are given according to
      the experience gained from this study. The Author enumerates the surgical
      techniques he has found most suitable for the conservative treatment of these
      tumors when resection is indicated.

PMID- 1013501
TI  - The magnitude of the breast cancer problem.

PMID- 1013502
TI  - Genetic predisposition to breast cancer.

PMID- 1013503
TI  - Steroid receptor proteins and regulation of growth in mammary tumors.
AB  - The failure of the estrogen receptor test to predict unequivocally whether a
      breast cancer will respond to endocrine therapy has prompted us to re-examine the
      spectrum of responses that might be expected in a hormone-sensitive tissue. Three
      basic responses are recognized; initiation of DNA synthesis and cell
      proliferation; negative feedback; and autophagia. The expression of these
      responses may be partly or totally deficient in tumors. In some tumors,
      resistance to hormone may result from the lack of entry of hormone into the
      nucleus; in others the interaction of hormone with chromatin is probably abnormal
      Evidence is presented in support of the idea that the presence of steroid in the
      nucleus is strongly correlated to the presence of cytoplasmic receptor. The
      results also suggest that there is a strong link between the presence of steroid
      in the nucleus and the initiation of DNA synthesis. Finally the disappearance of
      nuclear receptor and the onset of autophagia seem to be related catabolic events.

PMID- 1013504
TI  - Some thoughts concerning the primary therapy of breast cancer.

PMID- 1013505
TI  - The role of radiation therapy in the loco-regional treatment of breast cancer.
AB  - After having briefly considered the role of irradiation in the loco-regional
      therapy of breast cancer, the role of irradiation as a treatment modality aimed
      at conserving the breast is emphasized. A total of 457 patients were treated
      either by tumorectomy plus irradiation by 60Co (101 cases) or by primary
      irradiation (356 cases) with a follow-up of over 5 years. The results are
      encouraging and similar to those obtained by more standard treatments,
      particularly by surgery. Among the patients cured, 2 out of 3 have kept their
      breast with a satisfactory esthetic quality. However, the author insists on the
      difficulties presented by the irradiation technique, on the necessity of a close
      cooperation between the surgeon and the radiotherapist, and on the importance of
      a regular and frequent clinical, mammographic, and thermographic follow-up.

PMID- 1013506
TI  - The role of chemotherapy in the treatment of breast cancer.
AB  - A wide variety of approaches are being applied to the therapy of breast cancer.
      Treatment begins with a biopsy followed by mastectomy to remove the primary
      tumor. The risk category must be determined and, at present, an axillary
      dissection appears to be required; in the future, tumor cell markers may replace
      the role of an axillary dissection in the determination of risk category (TORMEY
      et al., 1975). If the nodes are positive, adjuvant chemotherapy and possibly
      immunotherapy should be considered. A positive estrogen receptor assay suggests
      that patients may also benefit from endocrine treatments. If it is negative, the
      chances of responding to hormonotherapy are very limited, except, perhaps, for
      anti-estrogens (McGUIRE, et al., 1975). Adjuvant therapy for patients with
      negative nodes is not recommended at this time; this view may have to be modified
      as the results of current adjuvant studies become available. We have at hand the
      means to improve the cure rate of patients with breast cancer. We are getting
      better diagnostic methods and find more patients with negative nodes. We know
      more about the primary treatment and have systemic modalities that are effective
      in the adjuvant situation. The immediate problem is to learn how to put these
      treatments together, and this task has been undertaken by on-going clinical
      trials. We are anticipating the results with optimism.

PMID- 1013507
TI  - The role of hormones in the modern treatment of advanced breast cancer.

PMID- 1013508
TI  - The role of nonspecific immunotherapy in the treatment of breast cancer.

PMID- 1013509
TI  - Utilization of diagnostic techniques for cancer of the breast - early diagnosis.
AB  - Early diagnosis of breast cancer is the only method with proven potential for
      lowering the death rate from the disease. Early diagnosis means, in a practical
      way, detection of preclinical cancer - finding the cancer before it would
      ordinarily be detected in the normal course of events. This involves mass
      screening of apparently well women.

PMID- 1013510
TI  - Human breast cancer in culture.

PMID- 1013511
TI  - Breast tumor modeling for prognosis and treatment.

PMID- 1013512
TI  - Population and family planning programs: a factbook.

PMID- 1013513
TI  - Changes in the Breuer-Hering reflexes following rostral pontine lesion.
AB  - The lung stretch reflex characteristics of unanesthetized decerebrate cats were
      determined using servo-controlled lung volume changes before and after bilateral
      lesion of the dorsolateral rostral pons in the region of nucleus parabrachialis
      medialis (NPBM). During the inspiratory phase the time-dependent threshold curve
      for inspiratory inhibition by lung inflation was shifted to larger volumes after
      lesion with no change in the constant describing its rate of decay. During the
      expiratory phase the gain of the inflation reflex was found to be increased by
      lesion, but otherwise to remain qualitatively the same. Deflations during the
      expiratory phase revealed a prolonged central inhibitory state with reduced rate
      of decay late in expiration. It is concluded that with intact vagi structures in
      the region of NPBM constitute but one of at least three sources of inspiratory
      inhibition, feedback derived from peripheral lung stretch receptors and from
      caudal pontine or medullary neurons also being involved. It is also concluded
      that the structures in the vicinity of NPBM affect the switching mechanisms
      differently during the two phases of the cycle: During inspiration they
      contribute a tonic threshold lowering input to the inspiratory "off-switch";
      whereas, during expiration they provide inspiratory-facilitatory influences late
      in the phase.

PMID- 1013514
TI  - Breath-to-breath variations of alveolar Po2 and Pco2 at barometric pressures of
      490, 745 and 1500 Toor in resting awake dogs.
AB  - Two awake, resting dogs born and raised at low altitude were studied, breathing
      air (1) at 745 torr, (2) during a 12 days sojourn at 490 torr in an altitude
      chamber, and (3) during 5 days sojourn at 1500 torr in a hyperbaric chamber. The
      respired gas was continuously sampled an end-tidal PCO2 and PO2 of sequences of
      thirty breaths were measured by fast analyzers. The mean value of alveolar PCO2
      was 29 torr at high altitude; 35 torr at 745 torr; and 40 torr in hyperbary. The
      changes of PCO2 indicate different alveolar ventilations which result mainly from
      the changes of the chemoreceptor drive which is enhanced at high altitude and
      decreased in hyperbary. The scattering of PCO2 is about the same at the three
      pressures. The scattering of PO2 is less at high altitude than at sea level, and
      less at sea level than in hyperbary. On a PCO2 vs PO2 diagram end-tidal PCO2 and
      PO2 points form elliptical clouds whose mean slopes decrease with the increase of
      total pressure. The characteristics of the dispersion of the alveolar pressures
      and of the slopes of the alveolar clouds depend on several factors among which
      the relevant steepness (i.e. capacitance) of the O2 and CO2 blood abosrption
      curves at the three pressures presumably plays the major role.

PMID- 1013515
TI  - Interaction of convection and diffusion in pulmonary gas transport.
AB  - Normal human subjects inspired various volumes of a normoxic argon mixture
      containing low concentrations of several biologically inert tracer gases with
      markedly different diffusivities (helium, neon, and sulfur hexafluoride). The
      behavior of Ne, Ar, and SF6 could be predicted on the basis of axial dispersion
      due to differences in diffusivity. For example, neon, having the highest
      diffusivity of the three, was more uniformly distributed within the bronchial
      tree than either argon or SF6. The behavior of helium, however, was not
      consistent with predictions based solely on axial diffusion. Contrary to
      expectation, the early portion of expiration was helium enriched while gas
      assumed to come from the alveolar regions contained relatively less helium than
      the other gases. Results of this study suggest that radial diffusion during
      convective bulk flow may play a significant role in intrapulmonary gas transport
      if relative diffusivity is extremely large. We conclude that diffusion gradients
      do exist within the bronchial tree during normal quiet breathing and that these
      gradients become less significant as inspired volume increases.

PMID- 1013516
TI  - Chemoreceptors in the paleopulmonic lung of the emu: discharge patterns during
      cyclic ventilation.

PMID- 1013517
TI  - Study of intrapulmonary gas mixing in man by simultaneous wash-out of helium and
      sulfur hexafluoride.

PMID- 1013518
TI  - [Laryngeal dyskeratosis; a new therapeutic approach: cordectomy with functional
      reconstruction by myoplasty].

PMID- 1013519
TI  - [Role of reconstructive laryngectomy in larynx surgery].

PMID- 1013520
TI  - [A little known deformity of the external ear: the conchal palm syndrome].

PMID- 1013521
TI  - [Importance of microdissection in maxillo-cervico-facial surgery (presentation of
      instrumentation)].

PMID- 1013522
TI  - A new Caloric Tester using ear canal balloon.

PMID- 1013523
TI  - [A case of laryngeal tuberculosis].

PMID- 1013524
TI  - [Use of radioisotopes in otorhinolaryngology examinations].

PMID- 1013525
TI  - [Clinical use of a new scintigraphic technic for the diagnosis of neoplasms in
      the field of otorhinolaryngology].

PMID- 1013526
TI  - [Acoustics of the earmould, the controlateral routing of signals process and its
      derivatives].

PMID- 1013527
TI  - [972 trial fittings of deaf children with hearing aids].

PMID- 1013528
TI  - [Superpowerful stereophonic hearing aids for the profoundly deaf child].

PMID- 1013529
TI  - [Use of open earmolds and directional electret microphones].

PMID- 1013530
TI  - [Indications for fitting hearing aids in ipsilateral routing of signal].

PMID- 1013531
TI  - [Personal note on fitting hearing aids with open earmolds].

PMID- 1013532
TI  - [Loudness of clicks: various data on impedance measurement].

PMID- 1013533
TI  - [Acoustical study of various prostheses; responses in transient noise and
      compression].

PMID- 1013534
TI  - [Preliminary observations on the masking phenomenon. The passing band and
      harmonic distortion relative to the construction of a prosthesis adapted to an
      unusual case of perceptual deafness].

PMID- 1013535
TI  - [Census of a little known school population: hearing-defective youngsters].

PMID- 1013536
TI  - [Technic of production and possible uses of germ-free animals].

PMID- 1013537
TI  - [Stress: attempted definition and classification].

PMID- 1013538
TI  - [What to do when the urea lead is elevated in diuretic treatment?].

PMID- 1013539
TI  - [A case of trisomy 8 in mosaic 47, XY, +8/46, XY].

PMID- 1013540
TI  - [Tolerance for and efficacy of the gel 1328 AN in sports injuries].

PMID- 1013541
TI  - [Balneology and rehabilitation. Dietitics and cardiovascular diseases].

PMID- 1013542
TI  - [Abnormally frequent otorhinolaryngologic infections in infants and children].

PMID- 1013543
TI  - [A difficult genetic counsel and an unexpected form of porphyria].

PMID- 1013544
TI  - [Differential diagnosis of jaundice].

PMID- 1013545
TI  - [X-ray diagnosis of jaundice].

PMID- 1013546
TI  - [Hemolytic jaundice].

PMID- 1013547
TI  - [Jaundice in pregnancy].

PMID- 1013549
TI  - [Neonatal jaundice and phototherapy].

PMID- 1013548
TI  - [Jaundice, prognostic element in biliary surgery].

PMID- 1013550
TI  - [Differential x-ray diagnosis of Crohn's disease].

PMID- 1013551
TI  - [Mesenteric compression syndrome: apropos of a case].

PMID- 1013552
TI  - [Early screening of language disorders in children].

PMID- 1013553
TI  - [Inflammatory linear verrucous epidermal nevus].

PMID- 1013554
TI  - [Percutaneous penetration].

PMID- 1013555
TI  - [Wissler-Fanconi syndrome or subsepsis hyperergica (1 case)].

PMID- 1013556
TI  - [Etiologies of erythema nodosum (a little known etiology: estro-progestagens)].

PMID- 1013557
TI  - [Cutaneous leishmaniasis (oriental button)].

PMID- 1013558
TI  - [Pyoderma gangrenosum: current aspects].

PMID- 1013559
TI  - [Tiberal treatment of leukorrhea caused by Trichomonas].

PMID- 1013560
TI  - [Neuroleptoanalgesia with Valium in bronchoscopy (apropos of 500 cases)].

PMID- 1013561
TI  - [Anesthetic mortality].

PMID- 1013562
TI  - [Farewell lesson].

PMID- 1013564
TI  - [Diagnosis: an answer, a stage or a question?].

PMID- 1013563
TI  - [New lights for the frontal mirror].

PMID- 1013565
TI  - [Problems of detection of malignant tumors].

PMID- 1013566
TI  - [Choice and prescription of antibiotics].

PMID- 1013567
TI  - [Suicide among the clientele of the general practitioner].

PMID- 1013568
TI  - [Evolutive aspects of cerebral vascular complications. Tomodensitometric study].
AB  - Seventy patients with clinical evidence of cerebral vascular accidents were
      studied by tomodensitometry. Forty-eight had clinical signs of acute ischaemia
      and, by means of 64 investigations, it was possible to follow the development of
      focal softening. Diagnostic difficulties encountered in the course of the first
      fortnight of development are described. Twenty-two patients exhibited clinical
      symptoms of meningeal or cerebro-meningeal haemorrhage. Eighteen haematomas were
      diagnosed and their development studied in 34 investigations.

PMID- 1013569
TI  - [Stark-Kaeser type of chronic scapulo-peroneal amyotrophy. Apropos of 10 cases].
AB  - The authors described 10 cases of scapulo-peroneal amyotrophy of spinal origin of
      the Stark-Kaeser type. The main characteristics are a frequently dominant
      autosomal heredity, onset in the muscles of the legs, scapulp-peroneal weakness
      and amyotrophy with extension sometimes to the bulbar muscles, areflexia without
      sensory disturbances, an electromyogram of the neurogenic type with a normal
      conduction rate, neurogenic histological aspects with normal peripheral nerve. It
      does not usually result in severe disability. This syndrome is related to the
      scapulo-peroneal or facio-scapulo-peroneal myopathies and the scapulo-peroneal
      neuropathies. The problem of the boundaries between these disorders and their
      association does not alter the fact that the concept of spinal amyotrophy of the
      Stark-Kaeser type should be kept as a reference group.

PMID- 1013570
TI  - [Familial form of centronuclear myopathy in the adult].
AB  - Two adult cases of centronuclear myopathy are described in a family from French
      Guyana. One of them, aged 23, has a slight weakness despite hypertrophic muscles.
      A typical picture of centronuclear myopathy was seen on muscle biopsy with
      atrophy of type I fibers and hypertrophy of II A fibers. His uncle, aged 53, had
      a progressive weakness of the lower limbs for the last 25 years, with also a
      pattern of centronuclear myopathy, but with more dystrophic features and atrophy
      of both type I and II A fibers. The mode of inheritance is dominant. These two
      cases are compared with the previously published reports. The pathogenesis of
      centronuclear myopathy is discussed.

PMID- 1013571
TI  - [H-reflex in the extensor digitorum brevis muscle: study in the normal subject
      and in latent alcoholic neuropathies].
AB  - A comparative electromyographic study was carried out in normal subjects (group
      I) and in alcoholics without clinical evidence of polyneuropathy (group II). -The
      H reflex of the extensor digitorum brevis muscle (E.D.B.), the electromyogram of
      EDB, the conduction velocity of the fasted motor fibers of the peroneal nerve
      (PN), the sensory conduction velocity and amplitude of the evoked potential of
      the cutaneous fibers of PN, the H reflex of the soleus muscle. -Two kinds of
      changes were observed in group II: --a significant increase in the latent period
      of H respones in EDB, in particular the latent period of responses provoked by
      distal stimulation of PN (+25 PER CENT); --A SIGNIFICANT DECREASE IN THE
      AMPLITUDe of the sensory potential of the PN(--46 per cent). The other parameters
      studied in group II did not show any significant difference in comparison with
      the control group. These results indicate that PN is involved early in a complex
      fashion in latent alcoholic neuropathies. They confirm that the distinction
      between axonal neuropathy and segmental demyelination is rarely absolute.

PMID- 1013572
TI  - [Adie's syndrome].
AB  - The author has investigated patients suffering from disorders of the pupillary
      reflexes and of the tendon reflexes of the lower limbs which come under the
      heading of tonic pupil. Forty-five patients were followed up over a period of 15
      years. The tendon reflexes of the lower limbs were recorded graphically and
      showed a very characteristic retardation of the second phase of the patellar
      reflex. The aetiopathogenesis of Adie's syndrome is discussed. The pathogenesis
      of Adie's syndrome has so far not been definitely established. We have merely
      tried to point out a few of the features which permit its early diagnosis and
      have drawn attention to the basic problem of the pathogenesis of certain neuro
      muscular disorders on the basis of secondary considerations involved in this
      uncommon syndrome.

PMID- 1013574
TI  - [Vision failure, hysteria or simulation? Collaboration between ophthalmologists
      and pedopsychiatrists].

PMID- 1013573
TI  - [Chronic functional dislocation of the cervical spine with radiculo-spinal
      effects. Discectomy by anterior route and fusion without graft].
AB  - X ray dynamic study of cerevical spine movements in 12 patients with neurological
      impairment has shown an abnormal mobility between two vertebrae in the anterior
      or posterior direction. This abnormal mobility which has been called functional
      dislocation, is situated usually over major discarthrosic lesions rather than
      under. This dislocation, which appears during voluntary and automatic movements
      of the head and neck has been qualified chronic. A discectomie through an
      anterior surgical approach and a bony fusion of vertebral bodies without any
      graft at the dislocation site lead to 10 good results. 2 failures have been
      imputed to the fact that there was a 10 years evolution of a tetraplegia before
      operation. The pathogenesis of chronic functional dislocation of the cervical
      spine is discussed with regard to compression and stretching of the spinal cord,
      roots and arteries of both. Traumatism of vertebral arteries during dislocation
      remain under discussion.

PMID- 1013575
TI  - [Personality and sensory-motor perversions of ocular origin].

PMID- 1013576
TI  - [Ocular self mutilation and psychopathology of gaze (1 case)].

PMID- 1013577
TI  - [Changes of calcium-phosphorus metabolism in patients with chronic renal failure
      on hemodialysis treatment].
AB  - Hemodialysis induced changes in calcium (Ca) and phosphorous (P) metabolism are
      studied in a group of ten (10) patients with chronic renal failure. There was a
      significant rise in total serum calcium (Ca), that was closely related to changes
      in serum proteins level, and a very significant decrease in serum phosphorous
      (P). Calcium levels of 7 to 8 mgs/100 cc in the dialyzer fluid were considered
      ideale.

PMID- 1013578
TI  - [Hematin treatment of porphyric neuropathy].
AB  - The authors report a case of acute intermittent porphiria with peripheral motor
      neuropathy and a syndrome of inadequate ADH excretion in a male patient aged 36
      years. Treatment with hypertonic glucose and prostigmine did not yield any
      beneficial results, while a subsequent treatment with hematine (4 mg/kg/day for a
      period of four days) produced a dramatic improvement in the clinical picture and
      in ALA and PGB levels. A back-to-normal shift of plasma and urinary electrolytes
      was also observed. It appears that there was a close relation between the
      administration of hematine and the clinical-biochemical remission.

PMID- 1013579
TI  - Relationship between the inhibitory activity on 'RCS' and prostaglandins
      synthesis and the anti-inflammatory activity of ketoprofen and several other non
      steroidal anti-inflammatory agents.
AB  - In this study ketoprofen has been shown to be the most potent of all anti
      inflammatory drugs in inhibiting the synthesis of prostaglandins and the 'rabbit
      aorta contracting substance' (RCS), using the guinea-pig lung preparation.
      Although there did not appear to be a close relationship between the activities
      of the various drugs in inhibiting prostaglandins synthesis and in their anti
      inflammatory activity, the compounds were ranked in the same order in both test
      systems.

PMID- 1013580
TI  - Action of ketoprofen on hepatic lysosome in the rat.
AB  - Evidence for the stabilizing effect of ketoprofen on the lysosomal membrane is
      presented. Ketoprofen was as potent as indomethacin in stabilizing lysosomes
      subjected to changes in osmotic pressure. This effect was more marked in rats
      with adjuvant arthritis than in normal animals.

PMID- 1013581
TI  - Synovial-fluid pharmacokinetics of ketoprofen.
AB  - A study was made of the plasma and synovial-fluid levels of ketoprofen after
      single oral doses of 50 mg and 100 mg given to patients with rheumatoid
      arthritis. The drug was rapidly absorbed and plasma levels were similar to those
      seen in healthy volunteers. The mean early plasma half-life of ketoprofen in both
      volunteers and patients with rheumatoid arthritis was 1.5 to 2 hours. A
      cumulative effect of ketoprofen was evident in the synovial-fluid of the patients
      studied.

PMID- 1013582
TI  - Some pharmacological and toxicological studies on ketoprofen.
AB  - Evidence for the effectiveness of ketoprofen in animal models of inflammation and
      its antipyretic effect is reviewed. Its toxicity in animals is discussed and the
      low tendency to produce ulcers is stressed.

PMID- 1013583
TI  - The uses and usefulness of electrically powered indoor wheelchairs.

PMID- 1013584
TI  - Femoral-head height loss: a study of the relative significance of some of its
      determinants in hip degeneration.

PMID- 1013585
TI  - A prospective study of 102 patients with the polymyalgia rheumatica syndrome.

PMID- 1013586
TI  - Progressive destruction of the femoral head in association with familial
      hypercholesterolaemia.

PMID- 1013587
TI  - Follow-up of hinge arthroplasty of the knee in rheumatoid arthritis.

PMID- 1013588
TI  - BXL Plastazote: a useful aid in both treatment and rehabilitation.

PMID- 1013589
TI  - Rehabilitation of non-walkers in rheumatoid arthritis.

PMID- 1013590
TI  - Septic arthritis of the sternoclavicular joint: complicated by fistula formation.

PMID- 1013591
TI  - Interview surveys of handicapped people: the accuracy of statements about the
      underlying medical conditions.

PMID- 1013592
TI  - Neurosecretory cells in the central nervous system of the prawn, Metapenaeus
      monoceros (Fabricius).

PMID- 1013593
TI  - [Origin and general meaning of evolutionary and ecological processes].

PMID- 1013594
TI  - Some observations on the ultrastructure of the sinus gland of the lobster,
      Palinurus polyphagus (Herbst).

PMID- 1013595
TI  - [Contribution to the knowledge of digestive enzymes in the transformers].

PMID- 1013596
TI  - [Histological studies on allografts and xenografts of lymphoid tissue in newts
      (Triturus cristatus Laur.) and xenopus (Xenopus laevis Daud.)].

PMID- 1013597
TI  - [Hemoglobin level and value of the hematocrit in full-term pregnancy:
      relationship between weight and sex of the newborn infant].

PMID- 1013598
TI  - [Use of the Limulus amebocyte lysate test for the verification of contamination
      with pyrogenic bacteria in hemoderivatives used in the coagulation area].

PMID- 1013599
TI  - [Recent findings on the relationship between the thymus and immune response : 1.
      Thymus hormone (thymic factor)].

PMID- 1013600
TI  - [Morphological and functional aspects of blood platelets preserved in DMSO at 
      180 degrees C].

PMID- 1013601
TI  - [Cerebral electrometry: sensitivo-sensorial loading test in hepatic coma].

PMID- 1013602
TI  - [Facial and lingual symptomatic myokymias due to neoplasms: electromyographic
      presentation of 3 cases].

PMID- 1013603
TI  - [Clinical and electromyographic contribution to the study of the Isaacs-Mertens
      syndrome (syndrome of spontaneous continuing activity of muscle fibers or
      neuromyotonia)].

PMID- 1013604
TI  - [Velocity of maximal motor nerve conduction in polyneuropathies of uremic
      patients subjected to various types of hemodialysis for varying periods of time:
      values and limitations].

PMID- 1013605
TI  - [Signs of soleus muscle denervation in dystrophic mice (extra and intracellular
      study)].
AB  - Extra and intracellular recording in vivo and in vitro and gold-chloride staining
      of the dystrophic mouse (Bar Harbour Strain) and of the normal controls soleus
      nerve-muscle preparation, has shown functional and anatomical denervation
      findings in the dystrophic muscles.

PMID- 1013606
TI  - [A case of rigid man syndrome (stiff-man syndrome)].
AB  - The Authors describe a case of "stiff-man syndrome" accompanied by all clinical
      and laboratory examinations; they point out the unusual implication of facial
      muscles and briefly report pathogenic theories and diagnostical criteria of this
      syndrome.

PMID- 1013607
TI  - [A case of eyelid apraxia in a subject affected by multiple sclerosis: clinico
      pathogenetic considerations].
AB  - The Author examines a pathological case of lids shuttening in a woman afflicted
      by multiple sclerosis, and by the light of the exant literature concludes for a
      case of apraxias, and includes the act of lids shuttening between the superior
      cortical functions.

PMID- 1013608
TI  - [Polygraphic recording of 2 secondarily generalized convulsive crises:
      correlations with intracranial pressure].

PMID- 1013609
TI  - [Comparative intra- and interhemispheric analysis of the EEG in coma].

PMID- 1013610
TI  - [Correlations between various personality factors and contingent negative
      variation (preliminary note)].

PMID- 1013611
TI  - [Cranio-cerebral injuries. Clinical and electrophysiological study of their
      severe sequelae].

PMID- 1013612
TI  - [Generalized status epilepticus of confusional manifestation in a patient with
      Ramsay Hunt myoclonic cerebellar dyssynergia].

PMID- 1013613
TI  - [Effects of amphetamine and phentermine on nocturnal sleep. Polygraphic study in
      normal subjects].

PMID- 1013614
TI  - [Neurophysiological observations on the restless legs syndrome].

PMID- 1013615
TI  - Persistent left superior vena cava, significance in emergency cardiac pacing.

PMID- 1013616
TI  - Surgery for ventricular aneurysm.

PMID- 1013617
TI  - Osteoid osteoma: a rare occurrence in the carpal navicular.

PMID- 1013618
TI  - Mushroom poisoning: Colorado experience 1972-1975.

PMID- 1013619
TI  - [Xerotomography of the trachea, bronchi and lungs (author's transl)].
AB  - The technical principles and the advantages of tomography with the
      xeroradiographic procedure were presented. The advantages of xerotomography over
      against film radiography are the simpler exposure procedure, the high degree of
      picture clarity, the wide range and the additional possibilities for information
      connected with it. These advantages were illustrated by a few examples. The
      disadvantage of this method is the high radiation exposure for the patient. For
      this reason, stricter indications must be required for this examination.

PMID- 1013620
TI  - [Present status of locating intraocular foreign bodies (author's transl)].
AB  - The different procedures used today to locate intraocular foreign bodies are
      discussed. The x-ray procedure is not adequate for splinters near the wall,
      questionable double perforations and foreign bodies which cannot be demonstrated
      radiographically. Complementary methods of examination such as transillumination,
      electroacustic location, ultrasonics and direct radio-optic controls must be
      used. Advantages and limitations of these individual locating procedures are
      discussed. Intensive transillumination with glass-fiber diaphanoscope is
      particularly important for splinters in the anterior section of the eyeball near
      the wall. Ultrasonics cannot be replaced by other methods for foreign bodies in
      the posterior section of the eyeball which do not produce shadows, demonstration
      of the relationship of the foreign body to pathologic intraocular structures and
      the measurement of the length of the eyeball. At the University Ophthalmic
      Hospital in Cologne, direct radio-optic controls are conducted with a stereo-x
      ray image amplitier, a stereoscopic image that gives.

PMID- 1013621
TI  - [Extensive lymphogenous and haematogenic formation of metastases in a case of
      malignant thymoma (author's transl)].
AB  - Case report on course and radiological symptomatology of malignant thymoma. The
      unusual course of the young patient and the extensive haematogenic and
      lymphogenic metastases are stressed. The current opinion on a low tendency of
      malignant thymoma to metastasize is discussed. Therapeutic regimen and
      radiological criteria of thymoma are described.

PMID- 1013622
TI  - [The problem of clinical and radiological control examinations of the female
      breast (author's transl)].
AB  - The question of follow-up care and radiological control examinations for the
      exclusion of the possibility of breast cancer has not been unanimously answered
      up until now. A suitable suggestion was made taking into consideration the risk
      factors, the authors' empidemiologic investigations as well as existing
      information regarding endocrine factors and morphology of the breast.

PMID- 1013623
TI  - [Differential diagnosis of star-shaped shadows on x-ray films of the female
      breast (author's transl)].
AB  - The mammographic demonstration of star-shaped shadows in the breast were reported
      in two cases. In both cases the lesions basically had to be classified as
      suspected malignancy, but the cytological examination showed the lesions to be
      benign scar tissue. Since mammography fails to demonstrate the boundry of a
      lesion which is seldom benign, such false positive diagnoses cannot be truly
      classified as "false diagnoses".

PMID- 1013624
TI  - [Carcinoma simulating alterations of the breast in axillary vein thrombosis
      (author's transl)].
AB  - Two observations of mammographic findings in axillary vein thrombosis showed the
      main similarities of alterations in the soft parts of the arm and/or breast (vein
      dilation, thickening of the skin, edema). Radiological findings can simulate the
      possibility of a tumor or even a total carcinoma.

PMID- 1013625
TI  - [Effects of xeroradiographic contour amplification in intramammary calcifications
      (author's transl)].
AB  - The pronounced edge-effect occurring in xeroradiography of intramammary
      calcifications leads to a change in size of the object, namely, a reduction in
      the positive and an enlargement in the negative print, to a hard-to-evaluate zone
      in the border of the object which is in about the same size range for both
      developing procedures. The extent of edge-enhancement is directly related to the
      structures in the immediate neighborhood. Form and density of microcalcifications
      can be better assessed with the positive procedure.

PMID- 1013626
TI  - [Radiologic examination of the breast stump (author's transl)].
AB  - The radiological examination of the breast stump is imparative since, with it,
      additional malignant tumors can be discovered and the degree of palpable
      alterations can be determined with a high degree of probability.

PMID- 1013627
TI  - [Early X-ray examen after operation on the upper intestine (author's transl)].
AB  - After operations the early x-ray examen of the upper intestine may show
      complications in the operation field. It also permits to judge the bowl's
      function. Most valuable is to compare pictures of the patient in lying and
      upright position.

PMID- 1013628
TI  - [External biliary fistula following severe rupture of the liver (author's
      transl)].
AB  - A patient with post-traumatic rupture of the liver was reported. The patient
      developed an external biliary fistula following removal of a cholecele the size
      of a child's head which was accompanied by copious drainage. Radiologic methods
      mor examining liver injuries and their later complications were discussed.

PMID- 1013629
TI  - [Long-term infusion-cholangiocholecystography as a routine method (author's
      transl)].
AB  - The efficiency and informative values of long-term infusion-cholegraphy was
      examined in 30 patients with hepatic elimination dysfunction or previous negative
      intravenous cholangiocholecystography. It could be shown that a diagnostically
      useful demonstration of the biliary tract could be obtained in 29 out of 30 cases
      by increasing bilirubin up to 3 mg% and by infusing contrast medium for 3 hours.
      In spite of the increase in iodine content, the infusion of contrast medium was
      better tolerated than the intravenous application of contrast medium. Hepatic
      toxicity could not be established.

PMID- 1013630
TI  - [Studies regarding a new contrast medium for demonstrating the patency of bile
      ducts (author's transl)].
AB  - The contrast medium Endomirabil was tested in 103 patients. It produced few side
      effects when 20 ml was injected pro examination over a 5 minute period. The rate
      of visable heterotopic contrast medium elimination is very low. The optimal time
      for making an x-ray to demonstrate bile ducts and gall bladder is 60-90 minutes
      after the injection. As a result, the number of x-ray films pro examination can
      be reduced. The unusually long filling of the bile ducts makes it possible to use
      tomography up to 90 minutes after the injection. This should be advantageous for
      radiological departments with limited capacity for tomography. Parenchymal
      damages induced by contrast medium could not be reduced from the chemical
      analyses.

PMID- 1013631
TI  - [About the advantages of the sonographic diagnostic in the field of the
      radiologist (author's transl)].
AB  - 1. Ultrasound techniques as a new diagnostical method are included in the work
      and administration of an already existing institution of a central hospital, i.e.
      the X-ray department. Avoiding a special organizational unit in the hospital or
      an organization depending on a department which e.g. a gynecology could not be
      asked to undertake (considering the amount of work and qualification needed)
      means an advantage from the economic point of view. 2. The radiologist is able to
      learn the interpretation of the B-Scan of the ultrasound method very quickly
      because the visual imagination necessary to handle both methods is the same. 3.
      Sonography is an important supplement for radiological diagnosis. 4. Suspecting a
      lesion of an retroperitoneal or intra-abdominal organ sonography can be used as
      the first check-up. Renal sonographie could prove to be a screening-method. Often
      the ultrasound finding indicates the further diagnostical procedures which are
      successful, saving X-rays and time. Under certain circumstances X-ray
      investigations can possibly be avoided. Considering the last two points would
      mean for the future that the radiologist indicates the diagnostical method to be
      used - not only the ultrasound but also the X-ray method. Five cases demonstrated
      confirm this conclusion.

PMID- 1013632
TI  - [Diagnostic native roentgenology of operated pituitary adenomas (author's
      transl)].
AB  - Cases showing the value and limitations of diagnostic native roentgenology in
      recurrent pituitary adenomas were selected from a total of 217 patients.
      Recurrence is recognized by progressive intrasellar space occupation. Bone
      apposition at the contours of the sella turcica resulting in reduction of volume
      and calcifications of the sellar region permit exclusion of intrasellar
      recurrence. Marking the area of operation improves native roentgenology. Bone
      apposition of acromegaly may obscure recurrences. According to the literature,
      about 50% of recurrences can be diagnosed roentgenologically. On the contrary
      recurrences can be excluded in 10-20% of roentgenologically successfully operated
      patients.

PMID- 1013633
TI  - [Radiation exposure of patients and personnel in the endoscopic retrograde
      cholangiopancreaticography (author's transl)].
AB  - The results of the measurement of radiation protection in 54 patients and the
      involved personnel exposed to radiation (physician performing the endoscopy and
      the radiologist) during ERCP were analyzed. The radiation exposure values were
      relatively low and were within the range of those doses to be expected for
      gastroenterologic radiodiagnostics. After many years of experience, the radiation
      exposure for patients and physician can be further reduced. Actual danger from
      radiation need not be feared for the patient or the exposed personnel. The range
      of maximum values for radiation exposure set-up in the regulations for x-rays is
      so broad that, with endoscopic centers need not be decreased. Rather it can still
      be considerably increased.

PMID- 1013634
TI  - [Cutaneous carbuncle: review of 220 cases].

PMID- 1013635
TI  - [Socioepidemiology of acute diarrheas, including cholera].

PMID- 1013636
TI  - [Saturnism in current preventive medicine].

PMID- 1013637
TI  - Residents' corner predisposition to infection and neutrophil function following
      hemorrhagic shock.

PMID- 1013638
TI  - Effect of dopamine and isoproterenol on pulmonary vascular resistance.

PMID- 1013639
TI  - Pancreatitis and severe metabolic abnormalities in patients taking phenformin.

PMID- 1013640
TI  - [Infantile form of S.C. neuronal ceroid - lipofuscinosis (author's transl)].

PMID- 1013641
TI  - [Picture of replication of influenza virus NWS in the mouse ependymal cells
      (author's transl)].

PMID- 1013642
TI  - [Epithelial lymphocytes and plasmocytes of human jejunum mucous membrane in
      malabsorption syndrome (author's transl)].

PMID- 1013643
TI  - [Macromolecular microscopy of proteoglycans (author's transl)].

PMID- 1013644
TI  - [A pathologist's remarks on kidney biopsy].

PMID- 1013645
TI  - [Students of the Czech medical faculty Charles University during the occupation
      (author's transl)].

PMID- 1013646
TI  - Binding of IgA to protein-A-containing staphylococci: relationship to subclasses.
AB  - Among 54 human monoclonal IgA proteins, 5 inhibited the binding of labeled human
      monoclonal IgM (IgM Se and IgM Ba) to protein-A-containing staphylococci, whereas
      48 did not have this ability. One protein (IgA Ha) showed discordant findings in
      the IgM Se and IgM Ba inhibitions assays. Among the 54 IgA proteins, 49 were of
      the IgA1 and 5 of the IgA2 subclass. All of the 5 IgA2 proteins inhibited the
      binding of IgM Se and IgM Ba to staphylococci, whereas the 48 proteins that
      reacted negatively in the two inhibition assays belonged to the IgA1 subclass.
      These findings show that the ability to react with staphylococci is a property of
      the IgA2 subclass. IgM proteins may also be divided into two groups based on
      different reactivities with protein A. It is proposed to call the two IgM
      subclasses IgM1 and IgM2, where the latter is defined by ability to react with
      protein A.

PMID- 1013647
TI  - Interactions between ricinus agglutinin and human IgA.
AB  - By affinity chromatography on Sepharose columns containing insolubilized ricinus
      agglutinin, all immunoglobulins of the IgA2 subclass and the polymers of IgA1
      were retained and could be eluted with lactose. Monomeric IgA1 showed a more
      heterogeneous reaction with ricinus agglutinin. The major part was unretarded,
      whereas some of it was weakly bound to the column and could be eluted with
      lactose.

PMID- 1013648
TI  - Genetic control of the in vitro responses of rat blood lymphocytes. II. Number of
      loci involved and linkage with in vivo antibody formation.
AB  - Blood lymphocytes from the inbred rat strains AS and BN differ in the magnitude
      both of their in vitro proliferative response to different mitogens and of their
      in vivo antibody response to the mitogenic fraction of phytohemagglutinin (PHA).
      We have examined the segregation of in vitro responsiveness to PHA in (AS X BN)F1
      X BN backcross rats and have tried to correlate it with other characters that
      vary in backcross rats. In vitro responsiveness is regulated by one or a few
      loci, is linked to the in vitro responsiveness to B lymphocyte mitogens and the
      in vivo antibody response to the mitogenic fraction of PHA, but is not linked to
      the major histocompatibility locus (Ag-B) nor to the frequency of short-lived
      small Ig-negative lymphocytes in blood. Lymphocytes from high-responder rats have
      a shorter lag period before the onset of DNA synthesis in vitro than low
      responder rats, and possibly also a higher number of in vitro responsing cells.
      To explain our findings, that the same gene og genes regulate in vitro
      responsiveness to different mitogens and in vivo antibody response to the
      mitogenic fraction of PHA, we suggest that the gene or genes act in an
      immunologically unspecific manner on the regulation of lymphocyte proliferation
      in vitro as well as in vivo.

PMID- 1013649
TI  - Genetic control of antibody responses to PHA in inbred rats.
AB  - Phytohemagglutinin (PHA-P; Difco) contains four immunogenic components. The
      antibody response in rats to two of these components is shown to be genetically
      determined: AS rats are high responders and BN rats are low responders to both
      antigens. Responsiveness to the two components segregates independently as
      autosomal, dominant traits in a manner that is compatible with a one-gene
      hypothesis for both responses. The antibody response to the mitogenic fraction of
      PHA segregates together with the in vitro mitogenic response to PHA and to other
      mitogens. These responses are not linked to the major histocompatibility complex
      (MHC) of the rat. The antibody response to a nonmitogenic fraction from PHA is,
      however, linked to the MHC.

PMID- 1013650
TI  - Immune response in asymptomatic paraproteinemia. I. Primary and secondary
      antibody response to Helix pomatia hemocyanin.
AB  - In a group of 20 patients with asymptomatic paraproteinemia, as judged after at
      least 3 years of follow-up, the primary and secondary antibody response to Helix
      pomatia hemocyanin (HPH) was defective as compared with the response in controls.
      The class of antibody was assessed by mercaptoethanol (ME) treatment of serum. A
      lowered response was found not only in the total but also in the ME-resistant
      (mainly 7S, IgG) antibody titer. Low anti-HPH antibody titers were preferentially
      found in the patients with high serum paraprotein levels, whereas in half of the
      patients with low serum paraprotein levels a completely normal antibody response
      was found. No differences in the total or 7S anti-HPH antibody response were
      found between patients with IgG, IgM, or IgA paraproteinemia. The polyclonal
      serum Ig levels were not predictive for the measured anti-HPH response. The
      anamnestic diphtheria and tetanus antibody response was not different from that
      of controls.

PMID- 1013651
TI  - Arming of lymphoid cells by IgG antibodies treated with protein A from
      Staphylococcus aureus.
AB  - Mouse spleen lymphocytes treated with rabbit IgG anti-sheep erythrocytes (SRBC)
      complexed with protein A of Staphylococcus aureus (SpA) form rosettes with SRBC.
      The attachment of SRBC to lymphocytes was due to the binding of the SpA-IgG
      antibody complex to the surface of the lymphocytes and was thus considered
      "arming" of the cells. Normal mouse spleen cells "armed" with SpA-rabbit IgG anti
      chicken erythrocytes (CRBC) kill specifically 51Cr-labeled CRBC "in vitro" in the
      absence of free antibodies. The killing by these "armed" cells is an effect of
      the cell-bound SpA-IgG antibody complex. Both the SRBC rosette formation and the
      cell-mediated CRBC killing was dependent on the concentration of the SpA-IgG
      antibody complexes used for "arming" the cells. A 100-fold increase in rosette
      formation or in killing of target cells was recorded for lymphocytes treated with
      SpA-IgG antibody complexes in comparison with cells treated with noncomplexed IgG
      antibodies. The specific binding of SpA-IgG antibody complexes to the Fc
      receptors of mouse spleen cells was demonstrated by inhibition studies. More than
      60% inhibition of the rosette formation and in the killing of target cells was
      shown for cells treated with normal rabbit IgG or its Fc fragment before addition
      of the SpA-IgG antibody complex.

PMID- 1013652
TI  - A method for the detection and quantitation of Fc receptor sites on cells.
AB  - A new rosette technique for identification of Fc-receptor-bearing cells is based
      on the ability of sheep erythrocytes coated with protein A of Staphylococcus
      aureus (ES) to form rosettes with cells treated with monomeric IgG or aggregated
      IgG. The IgG is attached to lymphocytes through its Fc region and binds to a
      trypsin-resistant but pronase-sensitive receptor (considered an Fc receptor). The
      ES rosette technique facilitates studies of the interaction of IgG with Fc
      receptor sites; the binding of any IgG preparation reacting with protein A of
      Staphylococcus aureus (SpA) can be studied by the technique. Inhibition of
      rosette formation by SpA was used for quantitation of IgG fixed to the cell
      surface (that is, the number of Fc receptors/cell). The sensitivity of the method
      permits quantitation of less than 10(5) IgG molecules bound to the Fc receptors.
      The relative affinity constant between Fc receptors and IgG ligands was estimated
      by plotting the percentage of ES rosettes as a function of IgG concentration and
      calculating the reciprocal of the IgG concentration giving half the maximal
      number of ES rosettes.

PMID- 1013654
TI  - Residual function in cortically blind hemifields.

PMID- 1013653
TI  - A token economy program for chronic schizophrenic patients.

PMID- 1013655
TI  - Tuberculin reactions related to interval between BCG vaccination and skin testing
      in guinea pigs.
AB  - Groups of BCG-vaccinated guinea pigs were given a single Mantoux skin test 4 to
      69 weeks after vaccination. The skin reactions tended to develop more slowly the
      longer the interval since BCG vaccination. Relatively quickly developing
      tuberculin skin reactions may be characteristic not only for repeated testing,
      but also for skin tests taken shortly after BCG vaccination.

PMID- 1013656
TI  - Epidemiological follow-up investigations of lung function. SEPCR working group
      meeting Gothenburg Sweden, 11th/12th June, 1976 [proceedings].

PMID- 1013657
TI  - Spirometry and flow-volume curves in 10-year follow-up in men born 1913.

PMID- 1013658
TI  - Longitudinal changes in ventilatory capacity amongst men over a 3-year period
      [proceedings].

PMID- 1013659
TI  - Factors related to EFV1 slope between two cross-sectional surveys 1960-72
      [proceedings].

PMID- 1013660
TI  - Serial data over 10-22 years for detailed lung function of working men
      [proceedings].

PMID- 1013661
TI  - Asbestos exposure and small airways disease [proceedings].

PMID- 1013662
TI  - An 8-year follow-up of FEV and respiratory symptoms in middle-aged men
      [proceedings].

PMID- 1013663
TI  - [Long-term course of anorexia nervosa].
AB  - A follow-up study has been recently conducted in 20 female patients with severe
      anorexia nervosa who had undergone stationary psychotherapeutic treatment at our
      clinic 8-16 years ago. Whilst according to our findings the prognosis for
      anorexia nervosa still remains poor, it does not seem quite so hopeless as is
      frequently presumed. Out of the 20 patients followed up, 5 now have chronic
      anorexia nervosa and in 2 cases transition to an endogenous psychosis has
      occurred (schizophrenia simplex with chronified anorexia in one, and endogenous
      depression after improvement of anorexia in the other case). 1 patient died in
      the interval between observations as a result of her anorexia. The general
      results of our investigation roughly confirm the rule-of-thumb predictions for
      many psychotherapeutic treatments of neurotic diseases, i.e. 1/3 unimproved, 1/3
      improved, 1/3 cured. Although free from illness, the majority of the patients
      must be described as conspicuous within the norm. The typical personal
      characteristics of the anorectic are maintained, their weight remains below
      normal level, and they suffer from eating problems. According to our
      investigation a positive prognosis correlates with onset of the illness before
      the age of 18, absence of laxative abuse, and subsequent marriage, whereas
      premature interruption of the treatment with return to the parental home proves
      to have a negative effect. In apparent contradiction to the persistence of the
      characteristic anorectic features is the evidence that out of the 20 patients in
      question 12 married and 8 had children. On the other hand, the fact that during
      the interval between observations 4 patients relapsed into severe anorexia in
      connexion with engagement or pregnancy indicates that acceptance of a mature
      female or maternal role often remains a problem. Of gynecologic interest is the
      fact that long-lasting secondary amenorrhea (up to 10 years, with an average of 5
      years) has not led to fertility problems for any of the married patients who
      wanted children.

PMID- 1013664
TI  - [Vitamin B 1 deficiency in chronic alcoholics and its clinical correlation].
AB  - 50 chronic alcoholics reporting to the medical emergency ward of Basle University
      Hospital with alcohol-related illness were examined with respect to thiamine
      nutritional status by means of the transketolase activation test of erythrocytes
      (ETK). 46% of the chronic alcoholics, compared to only 2% of the control
      population (1152 healthy adults), had transketolase activation quotients
      indicating a strong probability of thiamine deficiency (alphaETK greater than
      1.25). The most important symptoms associated with the biochemical parameters of
      thiamine deficiency were: anemia, pathologic liver functions (bilirubin, gamma
      globulins), low diastolic blood pressure and Wernicke's encephalopathy. There was
      a statistically significant correlation (p less than 0.05) between these symptoms
      and the biochemical parameters for thiamine deficiency. Therefore, when treating
      chronic alcoholics, these symptoms should direct attention to a possible vitamin
      B1 deficiency. Since the enzymatic vitamin B1 parameters correlate with the
      patients' hemoglobin, our results would be consistent with anemia influenced by
      provision of thiamine.

PMID- 1013665
TI  - [Effect of an oral contraceptive (ethinylestradiol/D-norgestrel) on growth
      hormone and insulin secretion].
AB  - The growth hormone, insulin and blood glucose values were measured during a
      glucose tolerance test in 12 women before and after 3 months' use of a
      contraceptive of the sequential type (11 pills containing 0.05 mg D-norgestrel
      and 0.05 mg ethinylestradiol and 10 pills containing 0.125 mg D-norgestrel and
      0.05 mg ethinylestradiol). Neither fasting blood glucose nor glucose tolerance
      are altered during administration of the contraceptive steroids. On the other
      hand, the reactive insulin level is significantly increased in comparison to the
      basal value, thus showing the signs of hyperinsulinemia. Both the gestagens and
      the estrogens appear to contribute to this disturbance of insulin secretion.
      Presumably the hyperinsulinemia is an expression of decreased sensitivity of the
      peripheral tissue to insulin. The growth hormone, a so-called insulin antagonist,
      is not responsible for the "insulin resistance" observed. The values measured by
      us after administration of the contraceptive do not significantly differ from the
      basal values.

PMID- 1013666
TI  - [The anti-hypertensive effect of timolol maleate (blocadren) in gradated
      combination with a diuretic].
AB  - In a controlled double-blind crossover study followed by an open longterm
      continuation period, the antihypertensive effect of timolol (Blocadren), a new
      beta-receptor antagonist, was investigated in 24 ambulatory patients with mild to
      moderate essential hypertension who were concomitantly receiving Moduretic as
      baseline diuretic therapy. The addition of timolol to one tablet daily Moduretic
      resulted in a clinically and statistically significant further reduction of
      supine and upright systolic and diastolic blood pressures. The average total
      daily dosage schedule for timolol ranged between 15 and 20 mg, with the same
      blood pressure lowering effect whether the divided dose was given twice or three
      times. Significant sinus bradycardia was consistently observed but well
      tolerated, with only one patient requiring dose reduction. After 48 weeks of
      treatment (comprising 46 weeks Moduretic and 36 weeks timolol) 20 of 22 patients
      were normotensive (supine diastolic blood pressure below 90 mm Hg) while in two
      the hypotensive response proved inadequate. One patient was dropped from the
      study after 3 days of timolol treatment because of acute bronchial asthma. When
      specifically questioned, one-third of the patients admitted experiencing cold
      extremities. One patient exhibited Raynaud's syndrome which was treated
      symptomatically while continuing in the study. In terms of electrolyte balance,
      the fixed combination of hydrochlorothiazide and the antikaluretic amiloride
      (Moduretic) as baseline therapy essentially proved adequate. On occasion,
      however, two subject revealed hypokalemia requiring short-term oral potassium
      supplement. During the initial 10 to 16 weeks a steady decline in serum potassium
      was observed but this stabilized itself thereafter. The concomitant
      administration of Moduretic and timolol (Blocadren) was shown to be an effective
      therapeutic regimen in patients with mild to moderate essential hypertension.
      This combination is particularly suitable for patient compliance in longterm
      therapy, as timolol can be given twice daily.

PMID- 1013667
TI  - New concepts and approaches to sudden cardiac death.

PMID- 1013668
TI  - [The spontaneous course of coronary disease].
AB  - The natural history of coronary atherosclerotic heart disease was studied in a
      retrospective analysis of 160 patients, who underwent coronary arteriography from
      1965 to 1969. All had at least one angiographically documented significant
      stenosis of more than 50%; the survivors were followed for at least 5 years and a
      maximum of 9 years. For the entire group, 5-year survival was 81%. Subdivided
      into single, double or triple vessel disease categories, the 5-year survival
      rates were 91, 85 and 63% respectively.

PMID- 1013669
TI  - [Coronary lesions in type II and IV hyperlipoproteinemias. Coronarographic
      study].
AB  - Coronary arteriography was performed in 24 patients with type-II and in 22
      patients with type-IV hyperlipoproteinemia. The findings of the present study
      allow definition of several angiographic characteristics which seem to be linked
      to the type of hyperlipoproteinemia. Patients with type II generally have more
      widespread disease in the coronary tree at younger ages than do those with type
      IV. Type-II patients usually have proximal and distal disease, whereas type-IV
      patients have more often proximal disease only. Significant stenosis of the main
      left coronary artery is frequent in type-II but very rare in type-IV patients.
      Extensive calcification of the ascending aorta, sometimes associated with
      narrowing of the proximal aortic root, is present in 25% of type-II but in none
      of type-IV patients.

PMID- 1013670
TI  - [The mobile coronary unit in Basel. Report on its use in 1974].
AB  - A comparative study has been conducted in two groups of patients with fresh
      myocardial infarction: 168 brought to the hospital by mobile coronary care unit
      and 200 hospitalized by the conventional patient transport system. Pre-hospital
      mortality differed markedly (8.6% in the former group and 26.5% in the latter)
      but there was no difference in hospital mortality (17.7 vs. 19.8%). The possible
      implications of these findings are discussed.

PMID- 1013671
TI  - [Frequency and prevention of ventricular arrhythmias after acute myocardial
      infarct].
AB  - In a controlled study using mexiletine and placebo, the incidence of ventricular
      arrhythmias after acute myocardial infarction (AMI) has been compared. The study
      covered 40 male patients who had sustained AMI and who in the first 48 h after
      onset of infarction had exhibited ventricular tachycardia, R on T-, multiform or
      close-coupled ventricular ectopic beats. Half of the patients were given either
      mexiletine (250 mg 8-hourly) or placebo. On the 4th and 10th day after onset of
      infarction a continuous 24-hour ECG was performed. 76% of the patients receiving
      placebo showed serious ventricular arrhythmias compared with 32% receiving
      mexiletine (p less than 0.05). These results demonstrate (1) the frequency of
      ventricular arrhythmias in a group of patients already at risk, and (2) the
      efficacy of an oral antiarrhythmic agent like mexiletine in the management of
      these rhythm disorders.

PMID- 1013672
TI  - [Simultaneous determination of the left ventricular dimensions in dogs by means
      of cineangiocardiography and echocardiography].

PMID- 1013673
TI  - [Echocardiography as a method for the determination of the severity of aortic
      insufficiency].
AB  - 4 groups of patients with different degrees of aortic regurgitation (mild n = 7,
      moderate n = 3, severe n = 21, and aortic regurgitation combined with organic
      mitral stenosis n = 5) were examined by means of echocardiography and compared
      with a control group of 10 healthy subjects. The purpose was to determine what
      information echocardiography may provide in regard to the severity of aortic
      regurgitation and whether patients with organic mitral stenosis can be
      distinguished from patients with Austin Flint murmur. Patients with mild or
      moderate aortic regurgitation could not be clearly distinguished by
      echocardiographic features from subjects with normal cardiac findings. However,
      patients with severe aortic regurgitation were likely to show the following
      characteristic changes: (1) early mitral valve closure, (2) diastolic flutter,
      (3) absence of the a-wave. If a premature mitral valve closure, i.e. a negative
      QC time or a diastolic flutter or absent a-wave are found, the aortic
      regurgitation is likely to be of severe degree. This finding will be particularly
      useful in patients with acute aortic regurgitation, no left ventricular
      enlargement and no left ventricular hypertrophy in the ECG. Being a noninvasive
      method, echocardiography may also be used in follow-up examinations. Furthermore,
      organic mitral stenosis can be distinguished from Austin Flint murmur.

PMID- 1013674
TI  - [Hemodynamic significance of myocardial bridging and milking effect of the
      anterior interventricular artery: a mild variant or source of angina?].
AB  - A hemodynamic study was conducted in 11 patients with myocardial bridging and
      milking effect (ME) of the left anterior descending artery (LADA), but with
      otherwise normal coronary arteries. During pacing, patients with grade III ME
      (over 75% narrowing of arterial size during systole) showed anterior wall
      ischemia, lactate production and severe angina. Thus, grade III ME observed on
      coronary arteriography may result in significant obstruction of the LADA with
      typical angina. Surgical treatment is worth considering in symptomatic patients
      with this rare anomaly.

PMID- 1013675
TI  - [Hemodynamic changes under metoprolol compared to propranolol in hypertensive
      patients].
AB  - The effect of the new beta-receptor-blocking drug metoprolol on hemodynamics and
      plasma renin activity was studied at rest and during exercise. 5 patients with
      essential hypertension were investigated before, 4 weeks after and 8 weeks after
      oral treatment (3 X 50 mg day). The results were compared to data of 5 patients
      under propranolol matched according to age, arterial blood pressure, and renin
      concentration. Metoprolol leads to a significant fall in renin and heart rate,
      whereas cardiac index is depressed only during exercise. Peripheral resistance
      remains unchanged and left ventricular filling pressure rises slightly. This
      results in a slight fall in arterial blood pressure. In comparison with
      propranolol the hemodynamic and renin patterns under metoprolol are similar, the
      only difference being the slighter fall in blood pressure due to a less depressed
      cardiac index.

PMID- 1013676
TI  - [Electrocardiograms of digitalis intoxication. Reevaluation].
AB  - Serum digoxin concentration and ECG were recorded 111 times in 96 patients taking
      digoxin. The generally accepted ECG criteria of digoxin concentration seem
      greatly to overestimate the incidence of toxic cases. According to these criteria
      63 ECGs in this study would have been regarded as toxic, whereas toxicity
      (defined by the association of serum digoxin elevation and clinical symptoms of
      toxicity) was actually present in only 11 cases.

PMID- 1013677
TI  - [Differential diagnosis of the deviation of the QRS left axis in ECG].
AB  - 100 ECGs with left axis deviation have been analyzed with respect to left
      anterior fascicular block (LAFB). On the basis of conventional criteria LAFB was
      diagnosed in 59 cases, but could be rules out in 26. Of the remaining 15 ECGs
      which at first seemed doubtful, 4 were identified as LAFB on the basis of a new
      criterion: duration of qR in a VL at least 40 msec longer than in V6.

PMID- 1013678
TI  - [Complications due to endocardial and epimyocardial electrodes in 171 patients
      with artificial pacemakers].
AB  - On the basis of experience with 171 patients the advantages and disadvantages of
      a sutureless, corkscrew-like myocardial electrode are compared with those of
      endocardial electrodes. Electrode complications were significantly less frequent
      in patients with sutureless myocardial electrodes and never lead to death.
      However, a benign postpericardiotomy syndrome was frequent (16% of cases).
      Electrode dislocation was the main complication in patients with endocardial
      electrodes.

PMID- 1013679
TI  - [Surgery of mitral valve stenosis: open or closed commissurotomy?].
AB  - Up to October 1975 a total of 206 mitral commissurotomies were performed in
      Berne. 170 patients underwent closed commissurotomy (CMC). In the period from
      1973, 36 patients underwent open commissurotomy (OMC). To compare results and
      operative risk as between OMC and CMC, the last 36 consecutive patients of the
      CMC group were selected for critical evaluation. Though not coinciding
      chronologically the 2 groups turned out to be essentially comparable with regard
      to preoperative clinical and hemodynamic findings. In neither group was there a
      hospital death. Frequency and severity of postoperative complications did not
      prove to be greater following OMC. Cerebral embolism was observed in 3 cases
      after CMC, whereas this complication occurred only once following OMC. On the
      basis of clinical, radiological and electrocardiographic data, OMC must be
      considered superior to CMC. The incidence of significant residual stenosis and
      the risk of causing mitral regurgitation appear to be lower. Without involving a
      higher operative risk, the open approach to mitral commissurotomy offers the
      following main advantages: safe removal of intraatrial thrombi, precise and
      complete incision of the fused commissures under direct vision, avoidance of
      leaflet tears, separation of fused chordae tendineae and incision of papillary
      muscles in order to remove subvalvular stenosis, debridement of calcium from
      leaflets, and repair of concomitant mitral regurgitation by valvuloplasty.

PMID- 1013680
TI  - [Electrocardiographic diagnosis of coronary insufficiency by means of right
      atrial pacing].
AB  - In 285 patients who underwent selective coronary arteriography and atrial pacing
      for electrocardiographic diagnosis of suspected coronary failure, the sensitivity
      of this test was found to be rather poor: 43% positive results for atrial pacing
      compared to 50% for the submaximal exercise test, 75% for the maximal exercise
      test and 63% for the isoprenaline infusion test. In our experience atrial pacing
      is of diagnostic value only where uncertainty persists after a negative
      isoprenaline infusion test and an exercise test likewise negative but for some
      reason submaximal.

PMID- 1013681
TI  - [Effect of coronary flow reduction on the coronary flow distribution, the
      myocardial metabolism and left ventricular hemodynamics].
AB  - Myocardial blood flow, left ventricular performance, regional myocardial
      metabolites (ATP, CrP, lactate) and a-v differences of oxygen, lactate and
      pyruvate were determined in 6 open chest dogs with cannulated left coronary
      artery. A mean flow reduction from 92 to 43 ml/min/100 g heart weight resulted in
      marked heart failure accompanied by extensive flow reduction to the endocard with
      nearly 10 fold increase of lactate and a decrease of CrP content to 50% of
      control. In contrast, flow and metabolic parameters of the epicardial part
      changed only slightly. Furthermore, the DPTI/SPTI-ratio showed a good correlation
      with the subendocardial CrP content (r = 0.93, p less than 0.01).

PMID- 1013682
TI  - [First evaluation of plasma L-lactate measurements by means of the "lactate
      analyzer 5400"].
AB  - The instrument used can measure lactate instantaneously by a semi-automatic
      method using an electrochemical-enzymatic sensor. In order to test the
      instrument, 3 series of measurements were carried out simultaneously by the
      Analyzer and by the conventional enzymatic method (Boehringer, Mannheim):
      "normal" plasma and "normal" blood was obtained from venous blood of healthy
      adults; pathological plasma, obtained by addition of a known concentration of
      lactate to normal plasma, was also tested. The correlation curves for these three
      series are reported. The coefficient r is between 0.95 and 0.98, which bears out
      the reliability of the measurements. Since a short period, this lactate analyzer
      is used in our research laboratory in obstetrics.

PMID- 1013683
TI  - [The relative therapeutic value of drugs in international comparison: differences
      between Switzerland and Canada].
AB  - In Switzerland the relative therapeutic value of various drugs (e.g. pyrazolone
      analgesics, phenacetin, clindamycine, clioquinol) is placed demonstrably higher
      than in Canada. In Canada, rare but possibly dangerous complications of drug
      therapy are considered to be of greater importance. Two factors might be
      responsible for these differences: 1. Compared with similar publications in
      Canada, drug advertisements in Swiss medical journals contain fewer warnings of
      untoward effects. This can be interpreted as an "information lag". 2. Since the
      link between an untoward effect and a drug is very difficult to establish with
      absolute certainty, it may be concluded that the drug is relatively inoffensive.
      This conclusion is drawn more often in Switzerland than in Canada. Uniformization
      of the way in which the physician is presented with information concerning
      untoward drug effects would be an important step towards the establishment of
      internationally accepted standards of drug therapeutic value.

PMID- 1013684
TI  - [Therapy of diarrhea].

PMID- 1013685
TI  - [Arthroscopy of the knee joint].
AB  - The clinical usefulness of arthroscopies of the knee joint has been evaluated on
      the basis of 282 examinations. The procedures were performed under general
      anesthesia with sterility precautions as for arthrotomy. In nearly all cases,
      direct observation of articular surfaces, synovial membranes and the menisci of
      the ventral two thirds of the joint was possible. The dorsal recessus, the
      posterior third of medial meniscus, the posterior cruciate and Baker's cyst could
      not be inspected. The diagnostic accuracy of arthroscopy was compared with that
      of double contrast arthrography. The results are as follows: incipient
      degenerative lesions of articular cartilage, especially chondromalacia of
      patella, and dislocated bucket handle tears of menisci are more accurately
      diagnosed by arthroscopy. For other meniscal lesions double contrast arthrography
      provides better results. - Arthroscopy allows the taking of synovial biopsies in
      cases of chronic synovitis. However, the results of histological examination are
      rarely of decisive value, though undetected lesions of articular cartilage have
      been frequently brought to light.

PMID- 1013686
TI  - [Effectiveness and tolerance of the rabies vaccine Lyssavac Berna].
AB  - Rabies vaccine derived from human diploid cells (Wyeth, Merieux) and the duck
      embryo vaccine Lyssavac Berna are prepared from beta-propiolactone-inactivated
      Pitman-Moore vaccine virus strain. A group of 113 seronegative veterinary
      students was vaccinated with Lyssavac Berna according to the 4-dose immunization
      schedule recommended by WHO. Seroconversion was obtained in all test persons. The
      vaccine was very well tolerated. In agreement with the literature we also found a
      relatively fast decline in the neutralizing antibody titer after this
      immunization procedure. However, a booster injection after one year resulted in
      an antibody rise with titer values comparable with or higher than those obtained
      after the primary vaccination course. An annual single revaccination dose should
      be sufficient to protect people at risk.

PMID- 1013687
TI  - [Diphenoxinhydrochloride, a new anti-diarrhea agent].
AB  - The new antidiarrheal drug difenoxin hydrochloride is a preparation with a broad
      range of action; it is suitable for symptomatic treatment of acute and chronic
      diarrhea of varying etiology and may be administered as additional medication in
      cases of specific intestinal infections accompanied by diarrhea. Difenoxin
      hydrochloride was tested in two studies involving 220 patients with acute
      diarrhea and 41 patients with chronic diarrhea respectively. Side effects were
      extremely rare and stool frequency and consistency returned to normal at a daily
      dose of about 6 tablets. This dose could be reduced for the chronic cases after
      initial treatment with the higher dose. Positive results were obtained within a
      very short time in more than 80% of the acute cases and in more than 70% of the
      chronic cases.

PMID- 1013688
TI  - [Late results after surgical treatment of carpal tunnel syndrome. A clinical
      follow-up study of 60 cases].
AB  - In a follow-up study 60 hands of 49 patients were examined 1-12 years after
      operation for carpal tunnel syndrome. The syndrome was diagnosied in the majority
      of cases on clinical examination only. Paresthesia, hypesthesia or anesthesia in
      the 3 1/2 radial fingers of the hand are typical signs. Some patients complained
      of severe pain irradiating towards the elbow and shoulder. The method of surgical
      treatment is described in detail. Of the 49 patients only 2 were dissatisfied
      with the result. Both patients suffered from stenosing arteriosclerotic disease
      of the peripheral arteries of the hand and their pain and paresthesia were
      relieved by thoracic sympahtectomy. 58% of patients had complete relief from from
      symptoms while the remaining cases had a significant reduction of symptoms and
      were satisfied with the result of surgical treatment. The results were better in
      those patients who were operated on soon after the onset of symptoms. From the
      results of this study it is clear that surgical treatment of carpal tunnel
      syndrome provides good results and that surgical treatment should be recommended
      without delay if conservative treatment is unsuccessful.

PMID- 1013689
TI  - [Radioimmunologic determination of TSH in dried blood stains: a possible
      screening method for the diagnosis of hypothyroidism in new born infants].
AB  - By a modification of the radioimmunoassay of TSH in plasma, a method has been
      introduced for the measurement of TSH in dried blood spotted on filter paper. On
      incubation of filter paper discs (6.5 mm diameter, corresponding to approx. 10
      mul blood) for 38 hs has the lower limit of detection was 10 muU/ml TSH 68/38. In
      100 blood samples, TSH was measured in plasma as well as in dried blood; the
      results were comparable and showed complete agreement in patients with high TSH
      concentrations suffering from primary hypothyroidism. In 16 out of 72 newborn
      children examined during the first 8 hs of life. TSH was slightly elevated. It
      would appear that our method is sensitive enough for detection of the
      physiological postnatal rise in TSH. Among 1400 infants in whom Tsh was measured
      on the 5th or 6th day simultaneously with routine screening for phenylketonuria
      (PKU), we found 1 case with markedly elevated TSH levels of greater than 100
      muU/ml. The child suffered from congenital goiter. The results of our study show
      that the measurement of TSH in dried blood spots is possible without particular
      difficulty. Becasue of the simplicity of blood-sampling, the stability of the
      TSH, the relatively low cost and the low number of false positive results, this
      method seems to be suitable for screening of new born infants. It could be
      carried out conveniently in combination with the screening program for metabolic
      diseases, which covers practically 100% of infants born in Switzerland.
      Congenital hypothyroidism is a relatively frequent disease (1:3000-1:7000) in
      which early commencement of treatment is of great importance for mental
      development. It would therefore be desirable for all infants to be screened
      during the first days of life for congenital hypothyroidism.

PMID- 1013690
TI  - [The radiation load of the Swiss population due to radiodiagnosis].
AB  - It is recommended that the so-called "genetically significant dose" (GSD) be
      applied as a quantitative index of the radiation exposure of the genetic material
      of a population, i.e. the dose which, if received by every member of the
      population, would be expected to produce the same total genetic injury to the
      population as do the actual doses received by the various individuals. The GSD of
      the Swiss population for the year 1971 was calculated on the basis of information
      received from physicians concerning approximately 60 000 patients. Exeripmental
      determination of the gonad dose was done in various hospitals with the aid of TLD
      dosimeter, and sensitive high-pressure and normal-pressure ionization chambers.
      The results show that the annual rate of increase of X-ray diagnostic
      examinations is 3-4% in Switzrland as elsewhere. The GSD for Switzerland amounted
      in 1971 to 42-43 mrad per person as compared with 22 mrad in 1957. The "annual
      mean marrow dose of a population" can be calculated from the single doses
      received from each part of active bone marrow irradiated in the course of an X
      ray examination and, as in the case of the genetically significant dose, from the
      demographic figures mentioned. The annual mean marrow dose (1971) for the Swiss
      population was tentatively calculated using the values of the mean marrow dose
      per examination of the UK survey of 1957/58 and amounts to about 121 mrad. Barium
      meal contributes about 30% of the total, while intravenous pyelography, carium
      enema, lumbar spine and mass miniature radiographies each account for about 10%.

PMID- 1013691
TI  - [Public hypertension screening and problems of individual long term control].
AB  - Four months after public screening for hypertension during the Swiss Trade Fair
      1974, a random sample of 302 hypertensives referred to private practitioners were
      interviewed to determine the impact of the screening on longterm control through
      private practice. 201 hypertensives went for further blood pressure control: the
      previously aware did so more frequently than the previously unaware (p less than
      0.01). 112 of 201 were confirmed as hypertensives by private practitioners: this
      occurred in 80% of aware but in only 36% of unaware patients. 94 were started on
      therapy. 76 of 112 (2/3) received further appointments. Another 101 hypertensives
      did not seek care. Main determinants were insufficient knowledge about
      hypertensive disease and a shorter period of formal education; half of them
      claimed "they felt perfectly well". In summary one third did not seek care,
      another third were not confirmed as hypertensive or were lost to follow-up, and
      only one third (50% of the aware and 10% of the unaware) were still under regular
      care. While community-wide screening provided an opportunity for educational
      compaigns and positively affected the behaviour of hypertensives who were already
      aware, the yield in terms of newly identified hypertensives still under control 4
      months later was extremely low. Before further developing community screening
      programs, feasibility studies must define mechanism for improved longterm
      control.

PMID- 1013692
TI  - Abnormalities of autonomic nervous control in borderline hypertension.
AB  - The systemic hemodynamic was investigated in 145 young male patients with
      borderline hypertension and 85 control subjects. Response of the cardiac output,
      stroke volume and the heart rate to sequential parasympathetic, beta-adrenergic
      and alpha-adrenergic blockade was used for assessment of the autonomic nervous
      tone. These investigations suggest that the apparently "innocent" minimal blood
      pressure elevation in borderline hypertension is associated with a number of
      physiologic abnormalities: The cardiac output, heart rate and stroke volume can
      be elevated. In all patients the peripheral resistance is abnormal. An abnormal
      distribution of plasma renin values is detectable. The plasma volume is decreased
      in a proportion of patients. A number of these abnormalities can be explained by
      a neurogenic mechanism. The elevation of the cardiac output is entirely
      neurogenic. In a substantial minority of patients, the elevation of peripheral
      resistance is attributable to increased sympathetic drive. Indirect evidence
      indicates that the plasma renin elevation in borderline hypertension may also be
      neurogenic. Hypothetically the decreased plasma volume may stem from sympathetic
      effects on postcapillary vessels, but at the present there is no experimental
      evidence of support this view. The change in autonomic function in borderline
      hypertension involves both the sympathetic and parasympathetic efferents.
      Increased sympathetic stimulation is coupled with decrease parasympathetic
      inhibition. This points toward abnormal integration of the autonomic control,
      presumably in the medulla oblongata. The mechanism of the autonomic abnormality
      is not fully elucidated. The role of baroreceptors requires further
      investigation. In some patients the altered autonomic integration appears to be
      related to psychosomatic mechanisms.

PMID- 1013693
TI  - The problems of morbidity and therapy in borderline hypertension.
AB  - The aim of the trial was to see whether it was possible to improve morbidity and
      mortality in both males and females with diastolic pressures between 90 and 109
      mm Hg. The initial calculations suggested that it would be necessary to screen
      between 250-500,000 people to obtain 18-36,000 subjects. This was the number
      predicted to obtain a statistically significant end-point on current knowledge of
      morbidity and mortality in this age range. The initial aim was to mount a trial
      of feasibility with the following objectives: (1) To recruit up to 1000 adults of
      both sexes aged 35 to 64 years with diastolic pressures in the 90-109 mm Hg
      range. (2) To determine the acceptability of the trial to asymptomatic subjects
      as well as their physicians. (3) To show that selected drugs (bendrofluazide and
      propranolol) adequately control pressure without undue side-effects. (4) To
      assess the psychological effects of inclusion in the trial. (5) To examine the
      cost and efficiency of different types of recruitment and supervision. These
      objectives have now been largely achieved with over 1500 subjects in the study at
      2 1/2 years and a drop-out rate of about 13% in all. It appears that the best
      method of recruitment and supervision is through family practices with supporting
      staff, particularly in the screening phase. Both the selected drugs reduce the
      blood pressure significantly and although the placebo groups also show a
      maintained fall of pressure, the difference from the treated groups is
      significant. There is no evidence of increased psychological stress by inclusion
      in the trial and those with psychological symptoms at the outset improve in
      comparison with their control subjects outside the trial. In order to reach an
      end-point which will give data of statistical significance, the trial should now
      be expanded as rapidly as possible towards the goal of recruiting 18-36,000
      subjects.

PMID- 1013694
TI  - [Non-specific effects of a drug study in hypertensive patients].
AB  - During the first phase of a drug study, 33 hypertensive patients received 2
      placebo tablets daily for 2 weeks as the sole treatment. Analysis of the blood
      pressure readings during this placebo phase shows that the study in itself
      creates a psychological climate which tends to decrease blood pressure. This
      effect should be taken into account when analyzing results of drug studies; only
      in studies with a double blind design is drug effect adequately judged.

PMID- 1013695
TI  - [Plasma renin activity and plasma aldosterone in essential hypertension: effect
      of age and diastolic blood pressure].
AB  - In patients with essential hypertension a gradual decrease in basal and
      stimulated renin secretion was found with increasing age. Stimulated plasma
      aldosterone decreased similarly; however, the observed changes were less
      pronounced. Young patients (less than 35 years) with high renin hypertension had
      lower diastolic blood pressure than patients with low renin hypertension in the
      same age group. Contrary to these findings, a markedly higher diastolic blood
      pressure was observed in patients over 35 years of age with high renin
      hypertension than in the group of patients with low renin hypertension. These
      results indicate that neither high nor low renin essential hypertension patients
      represent homogeneous groups. Furthermore, the dissociation between changes in
      renin activity and plasma aldosterone points to a disturbed relationship between
      the renin angiotensin system and aldosterone secretion in essential hypertension.

PMID- 1013696
TI  - [Effect of the angiotensin antagonist saralasin (1-sar-8-ala-angiotensin II) on
      the blood pressure in secondary hypertension].
AB  - The angiotensin antagonist saralasin (1-sar-8-ala-angiotensin II) was given to 27
      patients with different forms of secondary hypertension. The blood pressure fell
      in 6 of 7 patients with renal artery stenosis and in 4 of 10 patients with
      terminal renal failure on regular hemodialysis. No change or a rise in blood
      pressure was observed in 3 patients with Cushing's syndrome, 4 patients with
      primary aldosteronism, 3 patients with hypertension and a unilateral small kidney
      of other than renovascular origin, and 6 patients with terminal renal failure. It
      can be concluded from the results that angiotensin II is involved in the
      pathogenesis of renovascular hypertension and in some cases of hypertension
      accompanying chronic renal failure.

PMID- 1013697
TI  - [Correlations between blood pressure, blood volume, plasma renin and urinary
      catecholamines in normal subjects and in patients with benign essential
      hypertension].
AB  - Interrelations between blood pressure, circulatory volume, plasma renin activity
      (PRA) and urinary catecholamine excretion rates were studied in normal subjects
      and patients with benign essential hypertension. Mean plasma or blood volumes
      related to lean body mass, products of blood volume and the logarithm of PRA, and
      catecholamine excretion rates did not differ significantly as between normal and
      hypertensive subjects. In both normal subjects and hypertensive patients, blood
      pressure correlated positively with noradrenaline excretion rate (r = 0.40 and
      0.36 respectively; p less than 0.025), but not with adrenaline excretion,
      circulatory volume or the volume-renin product. The logarithm of PRA correlated
      inversely with mean blood pressure in normal subjects (r = -0.40; p less than
      0.001), but not in hypertensive patients; however, there was no convincing
      evidence of an inappropriate blood pressure-PRA relationship as a prominent
      feature in the hypertensive patients. PRA did not correlate with blood volume.
      Patients with low PRA relative to sodium excretion (21% of hypertensive
      population) were consistently normovolemic, but tended to be older and excreted
      less (p less than 0.025) adrenaline than normal or high-PRA patients. The patient
      subgroup with high PRA relative to sodium excretion (11% of population) was
      hypovolemic (p less than 0.02); despite this, urinary sodium output was high (172
      +/- 64 meq/24 hr). These data reveal no evidence for major roles of PRA,
      circulatory volume and free peripheral catecholamines in the maintenance of
      benign essential hypertension. Low-PRA essential hypertension is usually not a
      hypervolemic state, but may reflect diminished adrenergic activity, factors
      associated with aging and effects of a high systemic pressure. High PRA in benign
      essential hypertension may be at least partly a consequence of hypovolemia
      resulting from high blood pressure-induced sodium diuresis.

PMID- 1013698
TI  - [Spontaneous perforation of the colon in patients in hemodialysis].
AB  - Two cases of spontaneous perforation of the colon in hemodialysed patients have
      thus far been published. Our observation of 5 new cases seems to indicate that
      this complication is more frequent in hemodialysed patients than in patients
      without renal failure (27 cases in the literature). An abnormal tissue fragility
      and very hard fecal masses appear to be responsible for this dangerous
      complication. The association of aluminium hydroxyde and substances with
      antiperistaltic effect should be avoided, and constipation must be alleviated.

PMID- 1013699
TI  - [Comparative study on the elimination of pindolol (visken) and antipyrin in
      patients with liver diseases].
AB  - 25 patients suffering from different hepatic diseases were studied in order to
      investigate the elimination of the beta-receptor blocking drug pindolol in
      hepatic disease. Following an overnight fasting period the patients received
      simultaneously 3 mg pindolol intravenously and 1000 mg antipyrine orally. Plasma
      samples were taken at certain time intervals for 24 hs and urine was collected
      for 72 hs for the measurements of drug concentrations in plasma and urine. From
      these measurements different pharmacokinetic parameters were calculated for both
      drugs used in the present study according to a one-compartment open model. The
      total body clearance of antipyrine was selected as a parameter of the metabolic
      capacity of the liver microsomal enzyme system and was compared with the
      pharmacokinetic parameters calculated for pindolol by means of linear regression.
      There was no significant correlation between the total body clearance of
      antipyrine and the kinetic parameters of pindolol in any of the 25 patients
      irrespective of the differences in liver disease. On the other hand, 14 patients
      suffering from cirrhosis of the liver showed a significant correlation between
      the total body clearance of antipyrine and the overall elimination rate constant
      or metabolic clearance of pindolol. No correlation was found between antipyrine
      clearance and total body clearance of pindolol, as some patients with intact
      renal function excreted a higher proportion of pindolol in the urine as liver
      function decompensated. The mechanism of such compensatory elimination is
      unknown. In conclusion, the total body clearance of antipyrine known to represent
      metabolic liver function showed a significant correlation with the metabolic
      clearance of pindolol in patients with cirrhosis of the liver. For the other
      liver diseases investigated, too few patients were studied to calculate an
      adequate correlation.

PMID- 1013700
TI  - [Physiopathology of arterial hypertension. Role of the nervous system and of the
      hormones].
AB  - Maintenance of normotension rests upon the overall salt and water balance, which,
      in the event of disequilibrium, modifies body fluid, cardiac output and total
      peripheral resistance. The kidneys play a central role in this hydro-saline
      regulation. The central and autonomous nervous systems, the renin-angiotensin
      system, the mineralocorticoids, the antidiuretic hormone and the kallikrein
      bradykinin-prostaglandin system all affect this regulation and are closely
      interrelated. The role of each of these nervous and endocrine systems in
      hypertension, and their close interrelationship, is briefly reviewed.

PMID- 1013701
TI  - [Angiotensin II inhibitors for the diagnosis and treatment of hypertension].
AB  - Specific antagonists of the renin angiotensin system have been used to
      investigate the role of this hormonal system in blood pressure homeostasis and in
      different types of experimental and clinical hypertension. Using this approach it
      was possible to show that renin via angiotensin participates actively in blood
      pressure maintenace, particularly following sodium depletion. Such antagonists,
      if available for oral administration and taken together with a diuretic, would be
      useful therapeutically.

PMID- 1013702
TI  - [Swiss Society Against Hypertension].
AB  - The Swiss Association Against High Blood Pressure was founded recently to improve
      the detection and treatment of hypertensive patients. Efforts will be directed
      towards increased awareness among the population and the medical profession and
      generalization of blood pressure measurements.

PMID- 1013703
TI  - [Increasing the bronchial resistance by means of aortic occlusion in the dog].
AB  - In 11 spontaneously breathing, anesthetized dogs, suprarenal occlusion of the
      aorta was produced by means of a ballon-tipped catheter and maintained for 20
      min. The obstruction led to an increase in O2 saturation in arterial blood (the
      rise in wedge pressure alters pulmonary perfusion), in aortic pressure and in
      bronchial resistance. Bronchial resistance could be partially diminished by
      inhalations of atropine or terbutalin.

PMID- 1013704
TI  - [Factors influencing the rate of elimination of injected fat emulsions
      (Intralipid) in healthy subjects and in patients with coronary disease].

PMID- 1013705
TI  - [Hypothyroidism as a cause of an unexplained elevation of CPK in cardiac
      patients].

PMID- 1013706
TI  - [Difficulties in the diagnosis and evaluation of the severity of acute aortic
      insufficiency in bacterial endocarditis].

PMID- 1013707
TI  - [Intermittent pneumatic compression of leg and thigh: a new successful method for
      the prevention of postoperative thrombosis].
AB  - In a prospective study, 54 patients undergoing joint-replacement operations were
      randomized into a control and a treatment group. In the treatment group low
      pressure intermittent compression (Phlebo-Dynastat) to calves and thighs was
      started on the day of operation and continued until patients were fully
      mobilized. In 34 evaluable patients undergoing total hip arthroplasty the
      incidence of deep vein thrombosis (DVT) as determined by venography was 43% in
      the control group and 22% in the treatment group (p = 0.18). In 17 patients
      undergoing total knee replacement, DVT occurred postoperatively in 70% of the
      control group but in none of the treatment group (p = 0.002). The difference
      between the control and Phlebo-Dynastat group when comparing all patients was
      highly significant (p less than 0.005). Low pressure intermittent venous
      compression offers a welcome alternative method of thrombosis prophylaxis in
      patients with increased risk of bleeding.

PMID- 1013708
TI  - [Folic acid determination in the serum and erythrocytes by means of a competitive
      binding method with 125 iodine labeling].
AB  - Folic acid concentration in serum and erythrocytes was measured by radio assay
      according to the principle of competitive binding to proteins with 125I as
      marker. The method yielded a linear regression with readily reproducible results.
      The mean value in controls was 7.05 -+/ 3.4 ng/ml in serum and 386.8 -+/ 215.1
      ng/ml in erythrocytes. In chronic alcoholics the respective values were
      significantly lower: 4.79 -+/ 2.02 ng/ml for serum and 344.4 -+/ 198.9 ng/ml for
      erythrocytes. The clinical importance of folic acid estimations arises from the
      general frequency of folic aicd deficits. Latent folic acid deficiency is
      associated with lowered folic acid concentrations in serum and normal values in
      red cells. In manifest folic acid deficiency both concentrations are decreased.

PMID- 1013709
TI  - [10 cases of lactic acidosis during biguanide therapy (buformin and phenformin)].

PMID- 1013710
TI  - [HL-A antigens in De Quervain's thyroiditis].

PMID- 1013711
TI  - [The systolic time intervals in functional disorders of the thyroid: a simple and
      fast screening test].
AB  - The systolic time intervals (LVET, PEP, and ratio LVET/PEP) were determined in 53
      patients presenting with signs or symptoms of thyroid dysfunction. Patients with
      clinical evidence of congestive heart failure, with arterial hypertension or old
      myocardial infarction, and patients receiving cardioactive drugs, were excluded
      from the study. Thyroid function was evaluated by means of T3-RIA, serum thyroxin
      and TRH stimulation test.

PMID- 1013712
TI  - [Industrial fluorosis].
AB  - 43 potroom workers (aluminium industry) with fluorosis have been compared with 18
      foundry workers of the same age, but who had never been exposed to fluorides.
      Clinical examination revealed a higher incidence of articular pain and limitation
      of motion in the exposed group. The diagnosis of fluorosis is not only clinical
      but calls for other investigations such as urinary fluoride determination, bone
      radiology and, above all, bone biopsy for fluoride determination, histology and
      microradiography.

PMID- 1013713
TI  - [Hodgkin's disease: frequency of histological subgroups and survival after the
      appearance of extranodal organ disease].

PMID- 1013714
TI  - [Sporadic adult hypophosphatemic vitamin D resistant osteomalacia (phosphate
      diabetes) and hyperparathyroidism].
AB  - Report on a patient with osteomalacia due to renal phosphate loss. At onset the
      patient was aged 43 years. No other tubular defects were detected except
      glycinuria. The patient was followed over a period of 12 years. 3 years after
      treatment with oral phosphate and vitamin D3 persistent hypercalcemia developed
      with highly elevated levels of parathyroid hormone. After removal of one enlarged
      parathyroid gland serum calcium normalized, but elevated parathyroid hormone
      levels still persist. The spontaneous occurrence of hypophosphatemic osteomalacia
      in an adult male and its connections with the development of hyperparathyroidism
      are discussed.

PMID- 1013715
TI  - [Cranial polyradiculitis or the so-called Fisher syndrome].
AB  - In the light of 3 personally observed cases a description is given of
      polyradiculitis cranialis or socalled Fisher's syndrome, a separate form of
      Guillain-Barre-Strohl polyradiculitis. It is a combination of acute ataxia,
      areflexia and ophthalmoplegia. The cause is probably an immunological reaction to
      a harmless infectious disease. Reversible or limited demyelination is assumed.
      The demyelination occurs particularly in the peripheral nerves and their spinal
      roots, but also in the spinal-cerebellar pathways and possibly in the nuclei of
      the cranial or optic nerves. Diagnosis is based on detection of "albumino
      cytologic dissociation" in the cerebrospinal fluid and the finding of a lesion of
      the peripheral motor neuron in the EMG. Special drug therapy is unnecessary. The
      prognosis is good: complete remission is usually observed.

PMID- 1013716
TI  - [Diagnosis of myocardial infarct by means of a quick determination of the MB
      fraction of serum creatinephosphokinase].
AB  - A rapid method of determining creatine phosphokinase (CPK) isoenzymes using
      dithiothreitol, a reducing agent which activates the main fractions of the CPK
      molecule (MM and MB), was assessed in 68 subjects (34 with myocardial infarction,
      18 with skeletal muscle lesions, 16 normal). In acute myocardial infarction, the
      mean peak of CPK-MB in serum increases to 13.3% of the total CPK (range 8.8% to
      21%) from the 18th to the 24th hour after onset of symptoms, whereas in skeletal
      muscle lesions CPK-MB reaches only 1% of total CPK (range 0% to 2.9%), and in
      normal subjects CPK-MB is absent. This highly significant difference (p less than
      0.001) makes it possible to distinguish accurately between myocardial infarction
      and skeletal muscle lesions (trauma, hematoma, myositis, hypothyroidism). By its
      sensitivity (100%) and specificity (97%) this rapid and inexpensive method finds
      its optimal sphere of application in emergency wards and coronary care units.

PMID- 1013717
TI  - [Course and therapy of malignant melanoma].
AB  - The 3-, 5- and 10-year survival rates in 353 well documented cases of malignant
      melanoma in stages I, II and III are discussed in relation to condition of the
      patient when the disease was diagnosed, methods of treatment and the histological
      classes of CLARK and MIHM. The different forms of therapy (X-ray followed by
      excision, excision followed by X-ray, X-ray alone, excision alone) produce
      similar recovery rates. Significant differences observable are due to variations
      in the patients' condition (differences in the malignancy index). Histological
      classification confirms the benign nature of lentigo maligna melanoma (LMM) and
      superficial spreading melanoma (SSM) in comparison with nodular melanoma (NM).

PMID- 1013718
TI  - [Group psychotherapy in psychiatry].
AB  - Psychiatry has learned to regard the human being not only as an individual but as
      a social being. Accordingly, group psychotherapy has come increasingly to the
      fore in recent years and decades. In general the term "group psychotherapy" means
      simultaneous psychotherapy of a number of patients by one or two therapists.
      Sociological-interactional-horizontal and deep psychological-motivational
      vertical components combine in the therapeutic group to produce a resultant.
      Insight into unconscious motivations and social learning are stimulated in the
      therapeutic group. Through group psychotherapy, which can be administered as a
      treatment method alone or in combination with other therapies, inpatients and
      outpatients experience a framework which activates former experiences of
      collective life situations, e.g. in the family, and social valencies.
      Irrespective of the method of group psychotherapy (activity group psychotherapy,
      directive-suggestive group psychotherapy, group analysis, psychodrame or one of
      the accelerating methods) the group should always be group- and not leader
      centered. Hitherto published results of group psychotherapy show that the
      treatment depends much more on the therapeutic commitment of the therapist
      (moderator, facilitator) than on the psychotherapeutic school to which the
      belongs.

PMID- 1013719
TI  - [Body-centered psychotherapy (basic therapeutic principle)].

PMID- 1013720
TI  - [Body-centered psychotherapy (separation from other therapies and disciplines,
      status of clinical-experimental research)].

PMID- 1013721
TI  - [Why is sport in the modern industrial society necessary for mental hygiene?].

PMID- 1013722
TI  - [Sport-sciences within the scope of Swiss science policy].

PMID- 1013723
TI  - [Ultrastructural, biochemical and energy analysis of extreme duration performance
      (100km run)].

PMID- 1013724
TI  - [Etiology and prevention of sport injuries].

PMID- 1013725
TI  - [Accidents in gymnastics].

PMID- 1013726
TI  - [Epidemiology of ski-injuries].

PMID- 1013727
TI  - [Aptitude and training in the endurance sport].

PMID- 1013728
TI  - [Anatomical, physiological and biochemical bases of muscle contraction].

PMID- 1013729
TI  - A study on ceramide monohexoside from AH 109A, a strain of ascitic tumor cell in
      Donryu rats.

PMID- 1013730
TI  - Bilateral catamenial pneumothorax.

PMID- 1013731
TI  - On the recent cases of middle lobe syndrome.

PMID- 1013732
TI  - [Studies of potassium and sodium in ischemic changes of the human myocardium].
AB  - The results are presented of investigations concerning the potassium-sodium ratio
      in the human myocardium under ischaemia in correlation with macroreaction to
      dehydrogenases. The values found, though approaching those of the familiar
      experimental results, can hardly be regarded as reliable in diagnosing early
      ischaemic changes in autopsy material since they are affected by post-mortem
      changes.

PMID- 1013733
TI  - [Findings in protracted cyanide poisoning].
AB  - The authors describe instances of 16-hour, 7- and 18-day survivals as well as one
      case of cured cyanide poisoning from the clinical and morphological points of
      view.

PMID- 1013734
TI  - [Unusual fatal thoracic injury due to glass splinters].
AB  - The authors report on a case of unusual lethal penetrating puncture-incised
      thoracic wound in a male aged 33 following an incidental fall into the glass
      panel of a glass-panelled door. The glass splinters of the bre. The case as well
      as the pertinent literatury data and to the diagnostic problems pertaining to the
      determination of the injurious mechanism.

PMID- 1013735
TI  - [Socialist public health and the modern socioeconomic policy of the Party].

PMID- 1013736
TI  - [Statistical health information in the management of public health and in its
      planning].

PMID- 1013737
TI  - [Improvement of the methods of studying the state of health of the population and
      the utilization of the results obtained in public health].

PMID- 1013738
TI  - [Main research trends in the field of social hygiene and public health
      organization in light of the decisions of the 25th Congress of the CPSU].

PMID- 1013739
TI  - [Hospital service to coal mine workers].

PMID- 1013740
TI  - [Psychological and social rehabilitation of patients who have had a myocardial
      infarct].

PMID- 1013741
TI  - [Work organization experience of a pediatric polyclinic].

PMID- 1013742
TI  - [Experience with the use of office machinery in public health organs].

PMID- 1013743
TI  - [Importance of psychology in raising the training quality of specialists with a
      higher medical education].

PMID- 1013745
TI  - [Theoretical studies in modern public health planning].

PMID- 1013744
TI  - [Experience with the programmed instruction of expertise in temporary loss of
      work capacity].

PMID- 1013746
TI  - [Current problems in the economics of public health administration].

PMID- 1013747
TI  - [Dispensary method in Soviet public health].

PMID- 1013748
TI  - [Experience with creation of a traveling, constantly functioning system for
      rendering ambulatory services in a rural region].

PMID- 1013749
TI  - [Improving several forms of introduction and control of the effectiveness of the
      employment of advances in medical science].

PMID- 1013750
TI  - [Experience with the use of the "consultant" system in choosing pharmacotherapy].

PMID- 1013751
TI  - [Experience with preceptorship organization in an urban hospital].

PMID- 1013752
TI  - [Predicting various indicators of the development of institutes for postgraduate
      medical education].

PMID- 1013753
TI  - [Organization of the academic-research work of students in a medical school].

PMID- 1013755
TI  - [Basic trends in the treatment of theoretical public health problems].

PMID- 1013754
TI  - [Present state and prospects for the development of public health in African
      countries].

PMID- 1013756
TI  - [Social-hygienic studies of the family and improvement in dispensary care].

PMID- 1013757
TI  - [Scientific-technical progress and several problems in medical ethics].

PMID- 1013758
TI  - [Urban population requirements for resuscitation services and intensive therapy].

PMID- 1013759
TI  - [Experience with early hospitalization of patients with acute surgical diseases
      of the organs of the abdominal cavity in a rural region].

PMID- 1013760
TI  - [Principles of control for effective use of "articial kidneys"].

PMID- 1013761
TI  - [Modern computer technology and solution of problems in public health
      administration].

PMID- 1013762
TI  - [Experience with the operation of a student sanatorium-preventive facility].

PMID- 1013763
TI  - [Experience with the work of geriatric receiving rooms of urban polyclinics].

PMID- 1013764
TI  - [Forecasts of tendencies in the state of public health].

PMID- 1013765
TI  - [Determination of the demand for physician services in infectious disease
      offices].

PMID- 1013766
TI  - [Experience in the selection, placement and education of medical personnel in a
      central district hospital].

PMID- 1013767
TI  - [Organization of medical service and the course of rheumatism in children].

PMID- 1013768
TI  - [Organization of medical care for Tyumen students].

PMID- 1013769
TI  - [Organizational aspects of the development of dispensary care].

PMID- 1013770
TI  - [Some aspects of the spread of and organization of the fight against alcoholism
      and drunkenness].

PMID- 1013771
TI  - [Organization of a medical information service in the Institute of Nutrition of
      the Academy of Medical Sciences of the USSR].

PMID- 1013772
TI  - [Utilization of automated systems in the informational and bibliographic
      servicing of medical workers].

PMID- 1013773
TI  - [Experience in electronic computer utilization for control over discharging the
      proposals of an epidemiological health station].

PMID- 1013774
TI  - [Improving the effectiveness of teaching political economy in the medical
      institute].

PMID- 1013775
TI  - [Lecture in the educational process and its metodological bases].

PMID- 1013776
TI  - [Reliability of exams and tests for credit in medical schools].

PMID- 1013777
TI  - [Planning public health development in the USSR].

PMID- 1013778
TI  - [Complex method of evaluating effectiveness of premedication].

PMID- 1013779
TI  - [Serotonin metabolism and pulmonary hypertension in chronic lung diseases].

PMID- 1013780
TI  - [Antimitochrondrial antibodies in chronic liver diseases].

PMID- 1013781
TI  - [Significance of tuberculosis and chronic pneumonias as predecessors of lung
      neoplasm].

PMID- 1013782
TI  - [Organizational measures for improvement of medical assistance to patients with
      acute cholecystitis].

PMID- 1013783
TI  - [Morphological and histochemical changes in liver in pancreatitis].

PMID- 1013784
TI  - [Caroli syndrome associated with homologous serum hepatitis].

PMID- 1013785
TI  - [Diabetic amyotrophy].

PMID- 1013786
TI  - [NBT test in bacterial and non-bacterial diseases. Evaluation and prospects of
      its use].

PMID- 1013787
TI  - [Interferon reaction of leukocytes in diffuse connective tissue diseases].

PMID- 1013788
TI  - [Chronic lung diseases in modern therapeutic clinical practice].

PMID- 1013789
TI  - [Hepatic lesions and their sequelae].

PMID- 1013790
TI  - [Immunomorphological study of activity and process induced by viral antigens in
      chronic liver diseases].

PMID- 1013791
TI  - [Colloidal solution of 131-I labeled albumin microaggregates used for the study
      of the reticuloendothelial system of the liver].

PMID- 1013792
TI  - [Effect of diuretic therapy on acid-base equilibrium and electrolyte content in
      patients with liver cirrhosis and ascites].

PMID- 1013793
TI  - [Formation of biliary calculi following cholecystectomy].

PMID- 1013794
TI  - [Surgical method of obstructive jaundice caused by choledocholithiasis].

PMID- 1013795
TI  - [Roentgenological examination of extrahepatic bile ducts in patients with
      supraduodenal choledocho-duodenal anastomosis].

PMID- 1013796
TI  - [Comparative evaluation of modern triiodized contrast media used in
      cholecystocholangiography].

PMID- 1013797
TI  - [Diagnosis of external fistula of the pancreatic glands].

PMID- 1013799
TI  - [Intestinal lactase deficiency in chronic enteritis and changes of its activity
      due to the therapy].

PMID- 1013798
TI  - [Study of lactase deficiency as a pathogenic factor in acute and chronic
      intestinal diseases].

PMID- 1013800
TI  - [Thermovision as a diagnostic method in gastroenterology].

PMID- 1013801
TI  - [Cytochemical study of the endometrium in irregular bleeding].

PMID- 1013802
TI  - [Amandatine hydrochloride (Symmetrel) in the treatment of parkinsonism].

PMID- 1013803
TI  - [Conservative treatment of women in perforations of the uterus in legal
      abortions].

PMID- 1013804
TI  - [Incidence of endemic nephropathy on the territory of S.R. Serbia].

PMID- 1013805
TI  - [Treatment of wounds after episiotomy].

PMID- 1013806
TI  - [Determination of bacteriuria by means of Uricult method].

PMID- 1013807
TI  - [X-ray diagnosis of large tumoral masses in the abdomen of women].

PMID- 1013808
TI  - [Acute myocardial infarct due to a bee bite].

PMID- 1013809
TI  - [Carcinoma granuloso-cellulare. Report of 2 cases].

PMID- 1013810
TI  - [Conductibility of the sensitive fibers of the peripheral nerves of the arm in
      Charcot-Marie-Tooth disease].

PMID- 1013811
TI  - [Special gonad shield for comparative hip radiography of infants together with
      dosimetric studies].

PMID- 1013812
TI  - [Pitfalls in surgery and in the surgeon's life].

PMID- 1013813
TI  - [Problem of malignization in gastric ulcer].

PMID- 1013814
TI  - [Cooperation of the surgeon and hematologist in sudden peroperative hemorrhages].

PMID- 1013815
TI  - [Goiter relapsing after surgery. Its prevention and treatment].

PMID- 1013816
TI  - [Surgical treatment of breast cancer].

PMID- 1013817
TI  - [Functional view points in the classification and therapy of thoracic injuries].

PMID- 1013818
TI  - [Our experinces in treatment of thoracic injuries].

PMID- 1013819
TI  - [Traumatic false diaphragmatic hernia with an unusual complication].

PMID- 1013820
TI  - [Problem of congenital intersexuality from the viewpoint of the pediatric surgeon
      and endocrinologist].

PMID- 1013821
TI  - [Appendicitis and adnexitis. Principles of cooperation of surgery and pediatric
      gynecology in relation to the prevention of primary sterility].

PMID- 1013822
TI  - [Spontaneous amputation of part of the appendix in a 3-year-old child].

PMID- 1013823
TI  - [Reflex death of a 14-year-old boy after a minor injury of the back].

PMID- 1013824
TI  - [Anatomical and functional results of conservative treatment in diaphyseal
      fractures of the foreknee in children].

PMID- 1013825
TI  - [Supracondylar fractures of the humerus in children].

PMID- 1013826
TI  - [Accident rate from the viewpoints of life protection and preservation].

PMID- 1013827
TI  - [Hazards of working with inhalation anesthetics].

PMID- 1013828
TI  - [The anesthetic agent enflurane in plastic surgery].

PMID- 1013829
TI  - [Anesthesia and analagesia in patients with burns].

PMID- 1013830
TI  - [Anesthesia for early excisions in patients with burns].

PMID- 1013831
TI  - [Hazards of general anesthesia crush induction].

PMID- 1013832
TI  - [Utilization of tissue oximetry in general anesthesia].

PMID- 1013833
TI  - [Allergic reaction after succinylcholine iodide Spofa during general anesthesia].

PMID- 1013835
TI  - [Acid-base imbalance in drowning persons].

PMID- 1013834
TI  - [Erection as an anesthesiological problem in some types of urologic surgery].

PMID- 1013836
TI  - [The 60th birthday of Chief Physician Vratislav Tichy].

PMID- 1013837
TI  - Liver injury: a modern day surgical challenge.

PMID- 1013838
TI  - Traumatic rupture of the diaphragm.

PMID- 1013839
TI  - The early diagnosis of primary hyperparathyroidism.

PMID- 1013840
TI  - The role of colonoscopy in inflammatory bowel disease.

PMID- 1013841
TI  - The adult respiratory distress syndrome.

PMID- 1013842
TI  - Non-absorbable cystic duct ligatures and common duct calculi.

PMID- 1013843
TI  - Fibromuscular hyperplasia of the internal carotid artery.

PMID- 1013844
TI  - Fine needle cholangiography.

PMID- 1013845
TI  - Case presentation from the combined meetings of the departments of pathology and
      surgery, University of of Cape Town. Malignant lymphoma of the parotid gland.

PMID- 1013846
TI  - A sigh for psychiatry.

PMID- 1013847
TI  - Abrupt fall in the fetal heart rate during labour.
AB  - Cardiotocograms of 6044 patients in labour were examined for evidence of an
      abrupt fall in the fetal heart 50 beats within 3 minutes, without a demonstration
      of signs of recovery in the following 2 minutes. Only 9 instances could be found 
      - an incidence of 0,15%. Umbilical cord entanglement possibly played a role in 6
      of these instances, and 2 of the infants concerned were stillborn. Intra-uterine
      growth retardation was associated with deceleration in 3 infants, 1 of whom was
      stillborn.

PMID- 1013848
TI  - False interpretation of fetal heart role monitoring in cases of intra-uterine
      death.
AB  - Spiral scalp electrodes were applied in 30 cases of diagnosed intra-uterine death
      during labour to establish different patterns caused by maternal fetal conduction
      of the ECG. In 10 cases the signal was of high quality and in 20 cases the signal
      was of low quality, but nevertheless spurious fetal heart rate recordings were
      produced. The maternal heart rate is interpreted as apparent "fetal bradycardia"
      in all cases but 1. Maternal heart rate accelerations, most of them occurring
      during uterine contractions, were demonstrated in 12 cases and decelerations in 3
      cases. Changes in beat-to-beat variation were, however, rare.

PMID- 1013849
TI  - [Influence of umbilical cord entanglement on fetal heart rate].
AB  - Umbilical cord entanglement was found in 34% of 555 women in labour. One loop of
      cord around the neck of the fetus was seen in 29% of the women and two or more
      loops in 5%. Cardiotocograms of these patients were examined for abnormal heart
      rate patterns. Cord involvement did not influence the incidence of basal
      bradycardia or tachycardia, early or late decelerations, loss of beat-to-beat
      variation or acceleration patterns. Variable decelerations, however, were seen in
      23% of the patients with cord entanglement and in 7% without cord involvement.
      This difference is statistically significant (P less than 0.001).
      Subclassification of variable deceleration into different grades according to the
      amplitude of the deceleration, demonstrated the presence of cord involvement in
      50% of the patients with moderate variable decelerations. This incidence rose to
      65% when severe variable decelerations were demonstrated and to 75% when
      decelerations had increased during labour. Low Apgar scores at 1 and 5 minutes
      occurred 2 and 3 times more often, respectively, when cord involvement was
      present.

PMID- 1013850
TI  - A comparison of the uterine beta2-adrenoreceptor selectivity of fenoterol,
      hexoprenaline, ritodrine and salbutamol.
AB  - A study was undertaken to compare the uterine beta2-adrenoreceptor selectivity of
      fenoterol, hexoprenaline, ritodrine and salbutamol. The drugs in doses having an
      equivalent effect on uterine activity, were randomly administered as an
      intravenous bolus to 10 patients who had been induced at term. The cardiovascular
      and uterine effects of the drugs were recorded. The rise in maternal pulse rate
      was significantly less (P less than 0,001) after the administration of
      hexoprenaline when it was compared with fenoterol, ritodrine, and salbutamol.
      Hexoprenaline proved to be the most chronotropically beta2-selective drug, having
      the least effect on the beta1-adrenoreceptors of the heart, for an equivalent
      effect on the uterus. Blood pressure changes were less significantly different
      between the drugs. The clinical use in obstetrics of a highly beta2-selective
      sympathomimetic drug is discussed.

PMID- 1013851
TI  - The differential enlargement of the neurocranium in the full-term fetus.
AB  - There is a wide range of variation in the cephalic index in the full-term fetus.
      The index rises as birth weight increases. The correlation between birth weight
      and the cephalic index is significant (r = 0,65) at the 0,05 level. Increasing
      neurocranial size is associated with differential growth of the dimensions which
      determine endocranial capacity. A higher cephalic index is achieved by a
      disproportionately large increase in the biparietal diameter relative to the
      occipitofrontal dimension. This results in a more globular neurocranial form.

PMID- 1013852
TI  - Delivery of Siamese twins by Caesarean section.
AB  - The diagnosis of a pair of Siamese twins and their delivery by Caesarean section
      are described. A major cardiac anomaly precluded surgical separation.

PMID- 1013853
TI  - Effect of different pre-operative vaginal preparations on morbidity of patients
      undergoing abdominal hysterectomy.
AB  - Three methods of vaginal preparation carried out before abdominal hysterectomy
      are compared. The lowest post-operative morbidity was associated with the use of
      a povidone-iodine douche and gel during the pre-operative preparation of the
      patient.

PMID- 1013854
TI  - Facilities available in Cape Town for children with learning difficulties.

PMID- 1013855
TI  - New techniques in stapedectomy.

PMID- 1013856
TI  - Paget's disease of bone in South African Blacks.

PMID- 1013857
TI  - Neonatal and maternal cranial form.
AB  - The mean cephalic index (CI) in the normally grown full-term neonate is in the
      lower eighties. Because intra-uterine growth retardation causes a greater
      proportionate reduction in the biparietal than in the occipitofrontal diameter,
      the resultant CI is significantly lower (P less than 0,01) than in neonates who
      have grown normally. There is no significant correlation between maternal and
      neonatal cranial form as judged by the CI. In man, hereditary factors operate in
      the long period of postnatal growth and differentiation.

PMID- 1013858
TI  - Chronic granulomatous disease of childhood.
AB  - Two boys and one girl suffering from recurrent severe bacterial infections were
      investigated. All 3 exhibited normal cellular and humoral immunity, normal
      neutrophil phagocytic ability, and defective neutrophil bacterial capacity. The
      clinical features and laboratory findings in these patients are diagnostic of
      chronic granulomatous disease. A sex-linked inheritance pattern was confirmed in
      1 patient by the demonstration of a heterozygous carrier state in the mother.

PMID- 1013859
TI  - The diagnostic value of the tine and Mantoux tests in a general hospital.
AB  - Tine and Mantoux tuberculin tests were compared in 193 hospitalised White
      patients with a variety of illnesses. With the Mantoux test 52 (27%) were
      tuberculin-positive and 19 (9.8%) were positive with the tine test. Had the tine
      technique alone been used, 33 of 52 tuberculin reactors would have been missed.
      Additional findings were (i) a 73% positivity for Monilia antigen; (ii) the
      optimal time for reading the Mantoux tests was on the third, rather than the
      second day; (iii) tuberculin reactivity was not suppressed by either pyrexia or
      elevation of the sedimentation rate; and (iv) the use of avian PPD demonstrated
      very few reactors in this population. It is recommended that the tine test be
      replaced by the intradermal Mantoux test with stabilised freeze-dried PPD
      tuberculin supplied in test kits with diluent. This matter should be given high
      priorty in South African general hospital practice and population surveys.

PMID- 1013860
TI  - False aneurysm of the common carotid artery due to tuberculosis. A case report.

PMID- 1013861
TI  - Surgical treatment of gallstone ileus.
AB  - Seven cases of gallstone ileus are presented. It is suggested that the mechanism
      of intestinal obstruction is not by progressive enlargement of the stone.
      Recurrent gallstone ileus is reviewed. At the time of the primary operation for
      the relief of the intestinal obstruction, the gallbladder should be palpated, if
      possible. When stones are palpable they should be removed by a cholecystostomy to
      prevent early recurrence of gallstone ileus. The decision to do further immediate
      surgery on the biliary tree depends on the condition of the patient.

PMID- 1013862
TI  - Some aspects of the hepatic metabolism of ethrane.
AB  - From our studies of the rat we report observations on three aspects of the
      interaction of ethrane and liver. 1. Interaction of ethrane with cytochrome P450
      in vitro. 2. The effect of ethrane administration on glutathione levels in vivo.
      3. The effects of repeated ethrane administration in the absence and presence of
      microsomal enzymic induction on liver morphology. We conclude that ethrane has
      little or no propensity for damaging the liver.

PMID- 1013863
TI  - Heparin prophylaxis in thrombo-embolic disease.

PMID- 1013864
TI  - The world's last case.

PMID- 1013865
TI  - The new insignia.

PMID- 1013866
TI  - Does raw sugar cane juice protect against dental caries.

PMID- 1013867
TI  - Nasal septal perforations closed with a silastic button.

PMID- 1013868
TI  - [South African Medical and Dental Council: opening address at the meeting held in
      Pretoria, 18 October 1976].

PMID- 1013869
TI  - The value of the postoperative temperature chart as an aid to the diagnosis of
      deep vein thrombosis.
AB  - Forty consecutive patients with an abnormal postoperative pyrexia were
      investigated for deep vein thrombosis (DVT). All 80 lower limbs were examined by
      means of Parks 801 or 806 Doppler ultrasound apparatus. Doppler findings were
      confirmed by ascending peripheral venography or by the 125I-fibrinogen uptake
      method, or by both methods, in all cases. DVT was present in 9 limbs (11%). In
      89% of the limbs DVT was excluded. An abnormal postoperative pyrexial response,
      as defined in this text, is thus a poor sign of DVT. It should, however, not be
      ignored, as it was indicative of venous thrombosis in 15% of the patients in this
      study. Confirmation of DVT should be obtained wherever possible by ascending
      peripheral venography, Doppler ultrasound, or some other available method. The
      use of anticoagulants should be restricted to those patients in whom the
      diagnosis has been confirmed.

PMID- 1013870
TI  - South African underwater diving accidents, 1969-1976.
AB  - Since 1969 a survey of diving accidents involving South African amateur divers
      was undertaken. The South African Underwater Union diving accident report form
      was used, and various State agents (SA Police and inquest courts) and individual
      divers and club instructors were questioned. This survey covers the period up to
      the end of June 1976. Data acquired during the 8-year period 1969 - 1976 are
      compared. A conservative estimate from the number of certificates issued to club
      divers indicates a 25% increase in diver population, while the number of
      fatilities has decreased from 0,1% in 1971 to 0,016% in 1976, indicating the
      importance of accident reporting in determining safety trends. In general, a
      change in pattern is observed during the last 4 years, showing more SCUBA than
      breath-hold fatalities. The formation of the Decompression Sickness and Diving
      Accidents Investigation Panel as a further measure to decrease fatal diving
      accidents is discussed.

PMID- 1013871
TI  - Foot pigmentation in Blacks.
AB  - Pigmentation of the soles of the feet was studied during postmortem examination
      of 70 Black patients. Forty-eight (57%) showed some pigmentation (grade II) of
      the soles of the feet and 4 (6%) showed definite black spots, i.e. focal areas of
      dense black pigmentation (grade III). A distinction between clinical grade II or
      grade III lesions could not be made on the basis of microscopic appearance. No
      true naeyi were seen. Increases of melanin pigmentation and minor degrees of
      melanocytic proliferation were all that was apparent. Although the development of
      malignant melanoma may be related to the presence of black spots on the feet of
      darkly pigmented races, all such spots are certainly not naevi.

PMID- 1013872
TI  - Herpetic whitlow.

PMID- 1013873
TI  - Prospects of the development of the health protection in the U.S.S.R. during the
      Tenth Five-Year Plan.

PMID- 1013874
TI  - Investigation of the health status of a representative population sample of one
      region in the CSSR, by medical examinations. Part II: Results and conclusions.

PMID- 1013875
TI  - The importance of accepted standards of environmental hygiene for prevention of
      non-occupational diseases in workers.

PMID- 1013876
TI  - Work consumption of physicians in the country district hospitals of the Mongolian
      People's Republic.

PMID- 1013878
TI  - [Age of menopause in the DDR].

PMID- 1013877
TI  - [Epidemiologic aspects of traffic accidents].

PMID- 1013879
TI  - [Classification of Rumanian districts according to socioeconomic criteria].

PMID- 1013880
TI  - [Probability of healthy behavior].

PMID- 1013881
TI  - The attendances to physicians and morbidity in Poland (July 1967--June 1968).
      Part V: Respiratory diseases.

PMID- 1013882
TI  - A survey of ocular trauma.
AB  - A four-year survey of all ocular trauma cases admitted to a large metropolitan
      eye hospital was conducted for the purpose of generally documenting ocular trauma
      and evaluating prophylactic, demographic and etiologic factors. Of 6254 eye
      admissions, 7.5% were for ocular trauma; hyphema was the most common diagnosis.
      Injuries were evaluated according to site, cause, and age, sex and race
      distribution.

PMID- 1013883
TI  - [Excretion of catecholamines and their precursor DOPA in patients with
      meningococcal infection].

PMID- 1013884
TI  - [Diagnosis and treatment of acute autoagressive pneumonia].

PMID- 1013885
TI  - [Immunological reactivity in patients with pulmonary tuberculosis associated with
      diabetes mellitus].

PMID- 1013886
TI  - [Content of elements (iron, copper, manganese, nickel, aluminium, chromium, and
      strontium) in plasma and blood erythrocytes in lung and liver tissue in patients
      with acute pneumonias].

PMID- 1013887
TI  - [Results of polycardiography, rheography, and biochemical studies in patients
      with ischemic heart disease].

PMID- 1013888
TI  - [Physiopathological aspects of chronic bronchitis].

PMID- 1013889
TI  - [Clinical aspects and treatment of viral, viral-bacterial and bacterial
      pneumonias during influenza epidemic, 1974-75].

PMID- 1013890
TI  - [Indices of functional state of the adrenal cortex and binding capacity of
      transcortin in influenza].

PMID- 1013891
TI  - [Successes and failures in the practice of using chemopreparations].

PMID- 1013892
TI  - [Studies of pigment metabolism in patients with chronic viral hepatitis and liver
      cirrhosis].

PMID- 1013893
TI  - [Reaction of allergenic leukocytolysis in viral hepatitis B (serum hepatitis)].

PMID- 1013894
TI  - [Clinical aspects and therapy of acute form of brucellosis associated with
      opisthorchosis].

PMID- 1013895
TI  - ["Imported" visceral leishmaniasis (case report and several aspects of the
      problem)].

PMID- 1013896
TI  - [Clinical significance of lacticoacidemia in patients with meningococcal
      infection].

PMID- 1013897
TI  - [Production of intestinal L-glucosidase (invertase) in chronic enteritis and
      effect of several therapeutic factors thereon].

PMID- 1013898
TI  - [Age-specific peculiarities of the clinical course of influenza A
      (Victoria/3/75)].

PMID- 1013899
TI  - [Functional state of external respiratory system in patients with 2d stage
      chronic pneumonia and bronchial asthma].

PMID- 1013900
TI  - [Criteria of evaluation of the relation between the residual volume of functional
      residual capacity and total capacity of the lungs].

PMID- 1013901
TI  - [Effect of atropine on stimulation by secretin of the pancreatic secretion in
      patients with duodenal ulcer].

PMID- 1013902
TI  - [Diabetes mellitus caused by mucoviscidosis].

PMID- 1013903
TI  - [Urine excretion of catecholamines and DOPA in patients with newly diagnosed
      diabetes mellitus].

PMID- 1013904
TI  - Reversibility and the age of an allele. I. Moran's infinitely many neutral
      alleles model.

PMID- 1013905
TI  - Role of very slightly deleterious mutations in molecular evolution and
      polymorphism.

PMID- 1013906
TI  - On the founder effect and the evolution of altruistic traits.

PMID- 1013907
TI  - Distribution of nucleotide differences between two randomly chosen cistrons in a
      subdivided population: the finite island model.

PMID- 1013908
TI  - Alternatives to Lotka-Volterra competition: models of intermediate complexity.

PMID- 1013909
TI  - A phenotypic symmetric selection model for three loci, two alleles: the case of
      tight linkage.

PMID- 1013910
TI  - Phenotypic structure and bifurcation behavior of population models.

PMID- 1013911
TI  - Loss of alleles in a haploid population with varying environment.

PMID- 1013912
TI  - [Obesity].

PMID- 1013914
TI  - [Etiological aspects of obesity (author's transl)].

PMID- 1013913
TI  - [Epidemiology of obesity (author's transl)].

PMID- 1013916
TI  - [The obese child].

PMID- 1013915
TI  - [Endocrine causes of obesity].

PMID- 1013917
TI  - [Overweight and diabetes (author's transl)].

PMID- 1013918
TI  - [Possibilities for the treatment of obesity].

PMID- 1013919
TI  - [The treatment of obese people].

PMID- 1013920
TI  - [Epidemiology of breast cancer (author's transl)].

PMID- 1013921
TI  - [Diagnostic problems of the mammary diseases (author's transl)].

PMID- 1013922
TI  - [Prognostic significance of anatomopathological findings in mastopathia and
      breast cancer (author's transl)].

PMID- 1013923
TI  - [Hormone treatment in breast cancer].

PMID- 1013924
TI  - ["Reach to recovery" (author's transl)].

PMID- 1013925
TI  - Clomiphene treatment in male subfertility.

PMID- 1013926
TI  - Clinical and laboratory examinations with Prodectin.

PMID- 1013927
TI  - Immunochemical examinations in monoclonal gammopathies: anachronism or
      perspective of immunological research?

PMID- 1013928
TI  - Report on observations of 840 cardiac infarction patients treated at the coronary
      care unit.

PMID- 1013929
TI  - Combined vessel injuring action of adjuvant arthritis and cholesterol feeding. I.
      A new method for producing experimental atherosclerosis in rats.

PMID- 1013930
TI  - Combined vessel injuring action of adjuvant arthritis and cholesterol feeding.
      II. The influence of different types of drugs on the new model of experimental
      atherosclerosis.

PMID- 1013931
TI  - Treatment of vaginal candidiases and associated trichomonas infections with Klion
      D.

PMID- 1013932
TI  - Clostilbegyt in the treatment of secondary amenorrhoea due to functional
      infertility and ovulation inhibition.

PMID- 1013933
TI  - Aspirated foreign bodies in the tracheobronchial tree: report of 250 cases.
AB  - During the last 14 years, 250 patients with aspirated foreign bodies in the
      tracheobronchial tree were admitted to Kuwait Chest Diseases Hospital. Ninety-six
      per cent of the cases were under 10 years of age and 38% gave a clear history of
      foreign body inhalation. The rest were diagnosed either clinically, from the
      chest radiograph findings or because of unexplained pulmonary symptoms. In 247
      cases, bronchoscopy under general anaesthesia was successful in removing the
      foreign bodies. In only three cases was bronchotomy needed. Seventy per cent of
      the foreign bodies were melon seeds. Asphyxia and cardiac arrest occurred in four
      cases during bronchoscopy but the patients were successfully resuscitated. In 10
      cases a tracheostomy was done before bronchoscopy and the removal of the foreign
      body, while in five it was needed after bronchoscopy. Fifteen patients developed
      late complications such as recurrent pneumonia or atelectasis of the lung. Early
      diagnosis and adequate treatment are essential to prevent pulmonary and cardiac
      complications and to avoid radical lung surgery.

PMID- 1013934
TI  - Bronchial carcinoma in patients with pre-existing unilateral lung disease.
AB  - Forty-six cases of primary bronchogenic carcinoma occurring in patients with
      other unilateral pleuropulmonary diseases were studied. In 37 cases (80-4%)
      carcinoma developed in the previously healthy lung. All but one squamous-cell
      carcinoma and all of five undifferentiated small-cell carcinomas developed in the
      previously healthy lung while 7 of 15 adenocarcinomas were in the lung with
      impaired ventilation. It is suggested that the bronchial epithelium of the
      healthy lung is more exposed to exogenous carcinogens than that of the diseased,
      underventilated lung, resulting in a higher risk of development of squamous-cell
      and undifferentiated small-cell carcinoma.

PMID- 1013935
TI  - Refractory pneumothorax treated by parietal pleurolysis.
AB  - Pneumothorax, persisting in spite of efficient drainage, may in some cases be
      caused by discrepancy between lung volume and size of the pleural cavity. The
      logical treatment is reduction of the pleural cavity simultaneously with a
      traditional surgical procedure on the pulmonary tissue. An increasing number of
      refractory pneumothoraces--both spontaneous and istrogenic--is probably due to
      the fact that more people are living with and suffer the sequelae of pulmonary
      disease. During a 15-year survey a parietal pleurolysis, tailored to fit the size
      and shape of the lung, was performed in 10 patients as the main surgical
      procedure in 100 thoracotomies for 1130 cases of spontaneous and 62 cases of
      iatrogenic pneumothorax. The results were encouraging.

PMID- 1013936
TI  - A manometric assessment of oesophagogastrostomy.
AB  - Intraluminal pressures were recorded in 14 patients who had undergone
      oesophagogastrectomy. Seven of these had a mid-thoracic and seven a high cervical
      oesophagogastrostomy. The incidence of postoperative reflux complications in each
      group was noted. No pressure gradient across the anastomosis was detected in any
      patient but the upper oesophageal sphincter was shown to be retained as a
      functioning unit in all cases. It is considered that the thoracic anastomosis
      provides no demonstrable barrier to reflux. In addition, a high cervical
      oesophagogastrostomy does not adversely affect the upper oesophageal sphincter.
      The wider application of this latter procedure may be associated with a decreased
      incidence of postoperative reflux complications.

PMID- 1013937
TI  - Sarcoidosis of the upper respiratory tract and its association with lupus pernio.
AB  - In a series of 34 patients with sarcoidosis affecting the upper respiratory tract
      and nose, 26 had lupus pernio (LP) and 17 had sarcoidosis of the upper
      respiratory tract (SURT). In nine patients these features coexisted. A patient
      presenting with SURT carried a 50% risk of developing LP although one feature
      could be present without the other. Both were disorders of women of the child
      bearing years of life. SURT, like LP, was an indicator of chronic fibrotic
      sarcoidosis, developing insidiously and progressing indolently over the years. It
      was complicated by ulceration, septal perforation, and LP. Three patients had
      nasal septal perforations, in two instances following submucous resection. This
      operation is contraindicated in patients with active sarcoidosis, particularly
      when granulomas are found on nasal biopsy. The Kveim-Siltzbach skin test was
      positive in all patients with SURT, making it invaluable in the differential
      diagnosis of granuloma of the nasal cavity.

PMID- 1013938
TI  - Respiratory mechanics in airways obstruction associated with inspiratory
      dyspnoea.
AB  - Inspiratory muscle strength and the flow and elastic pressure opposing
      inspiration were measured in seven patients with severe airways obstruction who
      found inspiration difficult at rest. A comparison was made of measurements
      obtained from seven normal subjects and five patients with airways obstruction
      not experiencing inspiratory dyspnoea at rest. Measurements were also obtained
      when inspiratory dyspnoea was induced in the normal subjects by adding an
      inspiratory resistance or by voluntarily increasing lung volume. Compared with
      the controls the inspiratory muscle strength of the patients was reduced but was
      not significantly less than that of the patients without inspiratory dyspnoea.
      The pressure required to produce inspiratory flow was significantly greater when
      inspiratory dyspnoea was present (P = 0-01). However, there was considerable
      overlap in the pressures of those with and without inspiratory dyspnoea. A better
      relationship was obtained when muscle strength was considered. The ratio of
      inspiratory muscle strength to the pressure required to produce flow was 0-24 +/-
      0-07 (mean +/- SD) in patient with inspiratory dyspnoea, 0-10 +/- 0-03 in
      patients without inspiratory dyspnoea, and 0-033 +/- 0-019 in normal subjects.
      There was no overlap between the two patient groups. The ratios of the normal
      subjects were increased when inspiratory dyspnoea was induced and, with the
      exception of two cases, were all above those obtained when inspiratory dyspnoea
      was absent. Inspiratory dyspnoea was experienced with lower ratios in the normals
      than in the patients with airways obstruction.

PMID- 1013939
TI  - Particle deposition in the trachea: in vivo and in hollow casts.
AB  - The pattern of deposition within the respiratory tract of potentially harmful
      particulates is a major factor in assessing any risk from individual and
      community exposures. Although the trachea is the most easily observed of the
      conductive airways, very little information concerning its particle collection
      characteristics is available, information which is essential for a complete and
      realistic description of particle deposition patterns within the entire
      respiratory tract. Data on tracheal deposition are also needed for development of
      accurate predictive models for particle deposition. The pattern of particle
      deposition in the trachea, and its relation to air flow, was studied in a hollow
      cast of the human larynx-tracheobronchial tree. Results were compared with data
      obtained in humans in vivo and from previous studies in hollow casts. In
      addition, the relevance of tracheal deposition in the hollow cast test system to
      deposition in vivo was examined by a direct comparison of deposition in a cast
      prepared from the lungs of donkeys previously studied in a series of in vivo
      tests. The disturbance of the air flow within the trachea caused by the larynx
      promoted the deposition of suspended particulates throughout the length of the
      trachea, and especially in proximal regions. This proximal deposition was due
      both to direct impaction from the air jet coming from the glottis and to effects
      of the tubulent flow. Turbulence produced inhomogenous deposition patterns within
      the trachea for particles of all sizes, although its effect was more pronounced
      as size decreased. Tracheal deposition in the human cast was within the range of
      normal in vivo tracheal depostion only when a larynx was used during cast test
      exposures; this emphasizes the need for the use of realistic experimental test
      systems for the study of particle deposition patterns. The relative patterns of
      deposition in casts of the donkey trachea and in the same tracheas in vivo were
      similar.

PMID- 1013940
TI  - Pattern of total and regional lung function in subjects with bronchoconstriction
      induced by 15-me PGF2 alpha.
AB  - Closing volume (single breath nitrogen test), regional ventilation and perfusion
      (using intravenous xenon-133), and total lung function (TLC, VC, and FEV) were
      measured before and after intramuscular administration of 250 mug 15-methyl
      prostaglandin F2alpha (15-me PGF2alpha) in 10 healthy women. The cardiac output
      was measured with the Minnesota impedance cardiograph model 304A and the
      transthoracic impedance was used as an expression of the thoracic fluid volume.
      The slope of the alveolar plateau on the closing volume tracing showed a 271%
      increase 20 minutes after the prostaglandin administration, at which time the
      closing volume per cent (CV%) had decreased (P less than 0-01) and the closing
      capacity (CC%) had increased (P less than 0-05). Vital capacity (VC) decreased (P
      less than 0-01), residual volume (RV) increased (P less than 0-01), and the total
      lung capacity (TLC) remained unchanged. The maximal decrease (9%) in FEV1 was
      seen after 20 minutes. All these measurements except the slope of the alveolar
      plateau returned to control levels after 60 minutes. The redistribution of
      regional ventilation was more pronounced than that of the regional pulmonary
      blood flow. No change was observed in cardiac output and transthoracic impedance.
      None of the patients experienced any dyspnoea. Our results are consistent with a
      more pronounced effect of prostaglandin F2alpha on the small airways (the
      alveolar plateau) than on the larger airways (FEV1). In cases where an increase
      in the slope of the alveolar plateau is observed, the closing volume per cent
      should not be used as a measurement of the lung disease. It is concluded that the
      single breath nitrogen test (N2 closing volume) is more sensitive than the
      conventional tests.

PMID- 1013941
TI  - Aspects of serum and sputum antibody in chronic airways obstruction.
AB  - Immunoglobulin levels and precipitating antibody against a range of microbial
      antigens were measured in simultaneously collected serum and sputum samples from
      patients with chronic bronchitis (11), cystic fibrosis (9), bronchiectasis (9),
      and asthma (4). Sputum was prepared by dialysis and high-speed centrifugation
      methods. Results showed that it was possible to detect precipitating antibody in
      the sputum, and the rate was increased when both methods were used. A discrepancy
      was noted between the detection rate in the sputum and serum. This, combined with
      the lack of correlation between sputum and serum immunoglobulins, lack of
      relationship between bronchial inflammation and sputum immunoglobulins, and the
      lack of IgM in the sputum suggested that the antibody and immunoglobulin were
      locally produced. Sputum IgA (7S) in patients with chronic bronchitis was
      significantly lower (P less than 0-05) than that found in patients with cystic
      fibrosis and bronchiectasis. Significant differences (P less than 0-05) were also
      noted in serum IgG levels between patients with chronic bronchitis,
      bronchiectasis, and cystic fibrosis while serum IgM levels in patients with
      chronic bronchitis were significantly lower (P less than 0-05) when compared to
      serum levels in patients with cystic fibrosis. The presence of precipitating
      antibody in the sputum raises the possibility that type III reactions may be
      important in the pathogenesis of these conditions.

PMID- 1013942
TI  - Degradation of porstaglandin F2alpha in the human pulmonary circulation.
AB  - Degradation of prostaglandins (PGs) during passage through the human pulmonary
      circulation was investigated by measuring the transpulmonary plasma PGF2 alpha
      difference during continuous intravenous infusion of PGF2 alpha (5-10 mug/min).
      Seven patients with cardiological disorders and two patients with extensive
      pulmonary abnormalities were investigated during diagnostic cardiac
      catheterization. PGF2 alpha levels were measured by radioimmunoassay. The seven
      cardiac patients were found to have transpulmonary PGF2 alpha differences of 47
      88%, indicating metabolism of the PG in the lungs. A patient with extensive
      bronchiectasis had an apparently normal transpulmonary PGF2alpha difference
      despite gross abnormalities in routine lung function tests. A patient with
      primary pulmonary arterial hypertension showed no metabolism of PGF2alpha in the
      pulmonary circulation. The results show that PG degradation is an aspect of
      normal lung function and suggest that it becomes imparied when extensive
      pulmonary vascular damage exists.

PMID- 1013943
TI  - Histamine levels in plasma, blood, and urine in severe asthma, and the effect of
      corticosteroid treatment.
AB  - Plasma, whole blood, and urinary histamine levels have been determined in 64
      normal subjects, in 10 patients with severe asthma, and in 10 control patients
      with other illnesses. The mean whole blood levels did not differ between the
      three groups. The mean plasma level in the asthmatics was significantly greater
      than that of the normal subjects but not of the control patients. The urinary
      histamine output was lower in the control patients than in the normal subjects
      but in the asthmatics did not differ from that of the normals. Corticosteroid
      therapy caused a marked fall, often to barely detectable levels, of the whole
      blood histamine concentration of the asthmatic patients and restored the plasma
      levels to normal but did not affect urinary histamine levels.

PMID- 1013944
TI  - Transitory cerebral microvascular blockade after cardiopulmonary bypass.
AB  - Dogs were submitted to cardiopulmonary bypass (CPB) carried out under conditions
      calculated to generate large numbers of microbubbles and microemboli. On the day
      following the procedure the dogs showed evidence of neurological damage including
      impaired consciousness and ataxia. These abnormalities largely cleared within a
      week. When the animals were sacrificed at intervals after the procedure, the
      cerebral microvasculature was demonstrated by injecting a suspension a lamp black
      into the carotid artery. This revealed that multiple filling defects were present
      in the microcirculation of the brain immmediately after CPB and for two days
      thereafter. However, by seven days the microvascular blockade had disappeared,
      and the vascular blockade had disappeared, and the vascular pattern of the brain
      had returned to normal. Neuropathological findings were sparse and restricted to
      the cerebellum. This study suggests that the transient neurological syndromes
      that sometimes follow cardiopulmonary bypass for heart surgery may be due to a
      transient microvascular blockade, perhaps by microbubbles and microparticles.

PMID- 1013945
TI  - Surface ultrastructure of silicone rubber aortic valve poppetts after long-term
      implantation. A scanning electron microscope study of four poppets.
AB  - The surface ultrastructure, demonstrated by scanning electron microscopy, is
      described in four implanted Silastic aortic valve poppets. Ball variance was
      discovered at necropsy in two patients and clinically in one in whom the poppet
      was replaced. The fourth patient underwent reoperation, but ball variance was
      neither suspected nor found. All four poppets were densely coated with biological
      debris and microthrombi. The 'coat' was soluble in a weak solution of sodium
      hydroxide. The true Silastic surface beneath the coat was little altered compared
      with unimplanted poppets, even after 10 years' implantation.

PMID- 1013946
TI  - Degenerative changes in aortic root allografts placed in the right ventricular
      outflow tract of growing puppies.
AB  - Differently prepared aortic root allografts were implanted in the right
      ventricular outflow tract of growing puppies to determine the site of origin and
      progress of degenerative changes in these conduits. The three preparations
      assessed were as follows: group A, fresh and sterile grafts; group B, antibiotic
      sterilized grafts in nutrient medium; and group C, beta-propiolactone sterilized
      grafts. Although calcification of the aortic wall occurred in all groups, the
      aortic leaflets were minimally affected. A correlation between viability and lack
      of calcification and between viability and long-term function is emphasized.

PMID- 1013947
TI  - Symptomatic mitral myxomatous transformation in the elderly.
AB  - The clinical and pathological features of four patients with intractable heart
      failure, due to myxomatous change in the mitral valve, are described. It is
      suggested that this change may represent a response of ageing connective tissue
      to mechanical stress.

PMID- 1013948
TI  - Fragile lung in the Marfan syndrome.
AB  - Two cases of the Marfan syndrome presented with spontaneous pneumothorax. Both
      had chest radiographs showing bilateral bullae in the upper lung zones and
      pulmonary function tests consistent with mild emphysema. There were dereases in
      forced expiratory flow rates at low lung volumes, carbon monoxide transfer
      factor, and lung elastic recoil. It is suggested that pneumothorax and bullous
      emphysema in this syndrome are caused by a weakness in the pulmonary connective
      tissue framework.

PMID- 1013949
TI  - Pulmonary blastoma: a report of two cases and a review of the literature.
AB  - Pulmonary blastoma is the rarest malignant tumour of the lung. Two more cases are
      reported and the literature is reviewed. The first case, a woman, is the longest
      recorded survivor. An examination of all the reported cases shows that the tumour
      is less common and less agressive in women.

PMID- 1013950
TI  - A large intrathoracic parathyroid adenoma.
AB  - A case is described in which an unusually large parathyroid adenoma was visible
      on the plain chest radiograph taken during the investigation of hypercalcaemia.
      This was diagnosed preoperatively and a scheme is suggested whereby such a
      disgnosis can now readily be made. The differential diagnosis is discussed ant
      the literature is reviewed.

PMID- 1013951
TI  - [The efficacy of pharmacovigilance--principles and proposals].

PMID- 1013952
TI  - [Functional hypoglycemia: a trial of treatment with phenytoin. Effects on blood
      sugar and blood insulin curves].

PMID- 1013953
TI  - [Disappearance of the disordered postural regulation of cerebral circulation by
      the addition of benserazide in parkinsonism treated with L-dopa].

PMID- 1013954
TI  - [Treatment of cystine calculi with mercaptopropionyglycine].

PMID- 1013955
TI  - [Serum gas chromatographic determination of hypolipemic agents derived from
      clofibric acid].

PMID- 1013956
TI  - [Pharmacokinetic study in man of hypolipemic agents derived from clofibric acid
      after single and repeated administration].

PMID- 1013957
TI  - [The effects of a polyflavane on the results of different types of experimental
      hypoxia].

PMID- 1013958
TI  - [The effects of a polyflavane on acute experimental hypertension in the dog].

PMID- 1013959
TI  - [The effects of various nonhormonal antidiuretics in the dog submitted to a water
      or sodium load].

PMID- 1013960
TI  - [Risks in splenectomy].

PMID- 1013961
TI  - [Purulent meningitis. 8-year statistics from Drammen hospital].

PMID- 1013962
TI  - [Purulent meningitis in children. 6-year statistics].

PMID- 1013963
TI  - [Tuberculosis among immigrants].

PMID- 1013964
TI  - [Lymphogranuloma inguinale].

PMID- 1013965
TI  - [Classification of malignant melanomas].

PMID- 1013966
TI  - [Thymectomy in myasthemia gravis].

PMID- 1013967
TI  - [Urine analysis with reagent strips].

PMID- 1013968
TI  - [Coccygodynia. A study of 17 patients].

PMID- 1013969
TI  - [Sulfonamides--liver damage].

PMID- 1013970
TI  - Necrosis of a pulmonary lobe in a dog.
AB  - A six-year old female pug had very severe dysponea. A radiographic opacity was
      observed in the right cranial area of the thorax. After thoracotomy, the cranial
      lobe of the lung was removed. Microscopic examination revealed necrosis of the
      lung and vacular thrombosis. The possibility of a torsion of the affected lobe is
      discussed.

PMID- 1013971
TI  - The relation between sperm quality and the effect of ouabain on the motility of
      spermatozoa.
AB  - This paper reports the results of an investigation into the effect of ouabain on
      spermatozoa which have suffered from aging, sudden changes in temperature and
      deep-freezing. Normal spermatozoa of different boars under standard conditions
      show an evident variation in ouabain sensitivity. A definite relation could be
      established between the fertility of the semen of a boar and the ouabain
      sensitivity of this semen. Spermatozoa exposed to aging, sudden temperature
      changes or deep-freezing, showed a greater sensitivity for 10(-3)M ouabain than
      corresponding controls. We concluded that factors which are harmful to membrane
      quality of spermatozoa can be revealed by exposing them to ouabain.

PMID- 1013972
TI  - Use of the lysozyme test in the diagnosis of kerato-conjuctivitis sicca in dogs
      and cats.
AB  - Comparative studies of the lysozyme test (LT) and the Schirmer tear test (STT)
      revealed that the LT was not reliable in the diagnosis of kerato-conjunctivitis
      sicca (KCS) in dogs and cats. This is in contrast to its successful use in human
      patients. No M. lysodeikticus lysating substrates were detectable in the tear
      fluid of the normal cat.

PMID- 1013973
TI  - The effect of storage at 4 degrees C on antibiotic residues in kidney and meat
      tissues of dairy cows.
AB  - A method is described for the quantitative assay of antibiotic residues in the
      body of slaughtered farm animals by means of 3 types of agar media and 3 test
      organisms. With the help of programmed calculation procedures, data from large
      scale tests for antibiotic residues could be analyzed accurately and rapidly. The
      concentrations of penicillin G, ampicillin, amoxycillin, cloxacillin, cephapirin,
      cephacetrile, neomycin, kanamycin, and oxytetracycline in the kidney, and also of
      tylosin in meat from the diaphragm muscle of cattle treated parenterally with
      these antibiotics were measured periodically in samples kept at 4 degrees C for
      up to 7 days after slaughter. The concentrations of penicillin G, ampicillin,
      amoxycillin and the cephalosporins in the kidney decreased rapidly upon storage
      whereas the levels of the other antibiotics remained essentially unchanged.
      Antibiotic stability in the meat was considerably greater than in the kidney upon
      storage for 4 days, and neomycin meat tissue levels were not reduced during
      storage for up to 144 hours. Results are discussed in relation to the conduct of
      the official qualitative Sarcina lutea Kidney Test and the most desirable
      procedure for preparing meat samples for assay.

PMID- 1013974
TI  - Some steroids in the blood of mares suffering from endometritis and post-partum
      mares as compared to normal cycling mares.
AB  - It appeared that in mares suffering from endometritis the concentrations of
      pregnenolone, of the compound "5.4", and of progesterone in the blood during the
      first 2 days of the heat period were significantly higher than in normal cycling
      mares, in which the concentrations of all steroids were less than or equal to 1
      ng/ml. In five endometritis mares the "5.4" and progesterone concentrations
      decreased after the first days of the heat period, and at about two days before
      ovulation the values were comparable to those of normal cycling mares. Eight
      mares suffering from a severe endometritis did not ovulate, their oestrous period
      was prolonged, and the follicles became atretic. Possibly the relatively high
      progesterone content found in these mares, caused the reduction of the follicular
      growth, and this might explain the prolonged oestrous period which is observed in
      many mares suffering from endometritis. Often we observed in post-partum mares
      the same changes in concentration as in endometritis mares. An elevated level of
      these steroids was sometimes found in the blood a few days after foaling and, in
      four of eight post-partum mares, during the foal heat. Most probably this was
      caused by infection or stimulation of the uterus. The hypothesis is advanced that
      progesterone originating in the uterus can influence ovarian activity and that it
      may be one of the factors responsible for the anoestrous periods which can occur
      in mares with endometritis and in post-partum mares.

PMID- 1013975
TI  - [Once more Aujeszky's disease in veterinary practice and vaccination against it].

PMID- 1013976
TI  - [Destruction of Salmonella in fresh and deepfrozen broiler chickens by gamma
      irradiation (author's transl)].
AB  - Salmonella organisms present on poultry carcases after processing, were almost
      totally destroyed by gamma irradiation using a dose of 250 krads. This was the
      case with carcases irradiated in the fresh as well as with those irradiated in
      the deepfrozen state.

PMID- 1013977
TI  - [Results obtained after synchronisation of oestrus by prostaglandins in dairy
      cows (author's transl)].
AB  - Twenty-five mg. of PGF2 alpha were injected in forty-three lactating cows and
      eighteen young heifers at ten-day intervals to produce synchronisation of
      oestrus. Only twenty-four lactating cows (58 per cent) and fifteen young heifers
      (83 per cent) came on oestrus with two, three or four days after the second
      injection of prostaglandin. Within eighty hours after the second injection, all
      animals were inseminated with semen of good quality. This resulted in pregnancy
      in eight (19 per cent) dairy cows and ten (56 per cent) young heifers. Rectal
      examination at the time of the second injection revealed a number of changes in
      the lactating cows. There was undue follicular activity, follicular cysts were
      observed in several cases and a corpus luteum measuring more than 15 mm. in
      diameter was not present in 25 per cent of the animals. In addition, twenty-seven
      cows were synchronised by injection of 0.5 mg. of Estrumate (a synthetic
      prostaglandin analogue) during the puerperium. Injections were made twenty and
      thirty days post partum. Eighteen cows (67 per cent) came on oestrus within two,
      three or four days after the second injection. Insemination which was carried out
      during oestrus, resulted in pregnancy in five cows. Rectal examination did not
      reveal any abnormalities in these animals.

PMID- 1013978
TI  - [A case of lead poisoning in cattle].

PMID- 1013979
TI  - [Rotavirus infection in calves (author's transl)].
AB  - Several laboratory workers have demonstrated a viral agent, suspected of playing
      an important role in the aetiology of calf diarrhoea during the first weeks of
      life. Based on its morphology this agent was designated a Reo-like virus. Later
      the name Rotavirus was introduced. Rotaviruses were proved experimentally to
      induce diarrhoea in calves. Usually the course of the disease after similar
      experimental infection is mild, but could become worse with secondary bacterial
      infections. The available information on the virus itself, the clinical aspects
      of the infection, its pathogenesis, diagnosis, epidemiology and prevention are
      reviewed.

PMID- 1013980
TI  - [Studies on the bacteriological features of fresh meat. III. Effects of transport
      (author's transl)].
AB  - The bacteriological changes appearing on transport of legs of beef, pork carcases
      and parts of cattle and pigs were studied. Meat from three slaughter-houses was
      examined. Of the meat of each slaughter-house, specimens transported over a short
      distance, over a long distance or by the butcher's own vehicle were studied. The
      transported meat was found to be contaminated by bacteria which had developed on
      (other) meat. The hygienic condition of the meat-van obviously is a factor in the
      transfer of bacteria to legs and carcases; this was not observed where the parts
      were concerned. The effect of bacterial contamination was that the decrease in
      stability was most marked in meat showing low bacterial counts. The season during
      which the meat was transported and the temperature reached during transport were
      not found to have any appreciable effect on the increase in bacterial counts. Nor
      were any marked differences observed between slaughter-houses or the various
      transports to butcher's shops. On the other hand, there was a relatively marked
      increase in bacterial counts on a particular transport route on which the meat
      had to travel for periods varying from five to six hours.

PMID- 1013981
TI  - [Biochemical changes in the blood of calves with scours and their correction by
      fluid therapy (author's transl)].
AB  - Clinical studies in calves which were moribund as a result of scours showed that
      the circulation was disturbed, the body temperature reduced and locomotion
      impaired. Biochemical examination of the blood showed that metabolic adidosis was
      present in every case. As a result of the inadequate circulation, respiratory
      compensation was not detectable in the venous blood in every case. On the other
      hand, it was invariably detected in the arterial blood. Metabolic acidosis was
      mainly due to a marked increase in the concentration of lactic acid in the serum.
      The haematocrit had increased, the blood urea and serum phosphate concentrations
      showed an increase, whereas the blood glucose lecel was reduced. Treatment showed
      that administration of 2,000 ml. of an isotonic bicarbonate solution by
      intravenous drip resulted in disappearance of the metabolic acidosis. However,
      this form of therapy failed to bring about the disappearance of the circulatory
      disorders in a number of cases. On the other hand, treatment of these disorders
      was successful when 3 l. of distilled water with 30 g. of sodium bicarbonate and
      9 g. of sodium chloride, followed by 3 l. of distilled water with 14 g. of sodium
      bicarbonate, 12 g. of sodium chloride, 8 g. of potassium chloride and 100 g. of
      glucose were administered by infusion for 24 hours.

PMID- 1013982
TI  - [Influenza vaccination: which vaccine (author's transl)].
AB  - A comparative study of the literature of the past ten years showed that
      vaccination of horses and ponies against influenza is best done using adjuvant
      containing vaccines. Comparable results may probably be obtained by twice
      inoculating an aquenous vaccine. There are no drawbacks to the use of aluminium
      hydroxide as an adjuvant when mineral oil is used as an adjuvant, the first and
      second vaccinations do not present any problems.

PMID- 1013983
TI  - [Pro or con antibiotic combinations].

PMID- 1013984
TI  - [Alcohol and drugs].

PMID- 1013985
TI  - [Alcoholic cardiomyopathy].

PMID- 1013986
TI  - [Zieve's sydnrome].

PMID- 1013987
TI  - [Chronic alcoholism].

PMID- 1013988
TI  - [Psychosocial aspects of alcoholism].

PMID- 1013989
TI  - [Plastic surgery of the bile ducts with a transhepatic tube].

PMID- 1013990
TI  - [Clinicopathological aspects of ulcerative colitis].

PMID- 1013991
TI  - Human enterokinase.

PMID- 1013992
TI  - [Colonic and rectal leiomyoma].

PMID- 1013993
TI  - [The role of vagotomy in the treatment of duodenal ulcers].

PMID- 1013994
TI  - [Hepatocarcinoma with long term survival in a young woman (with considerations on
      the possible relationship between primary liver tumors and sex steroids)].

PMID- 1013995
TI  - [Abuse of laxatives].

PMID- 1013996
TI  - Effects of varying pacemaker sites on left ventricular performance.
AB  - The hemodynamic effects of the site of the artificial cardiac stimulation were
      studied in 17 open chest dogs. The right atrium and five ventricular sites (the
      inflow and outflow tracts and apex of the right ventricle, apex and lateral wall
      of the left ventricle) were stimulated electronically at a given rate, ranging
      from 130 to 190 per min. When cardiac performance during ventricular pacing was
      compared with those during right atrial pacing, the former uniformly caused a
      diminution of cardiac output and systemic blood pressure, without reduction of
      left ventricular end-diastolic pressure. Ventricular function curves, in which
      left ventricular stroke work was related to left ventricular end-diastolic
      pressure, shifted downwards and to the right during ventricular pacing.
      Stimulation frequency did not alter these variables. It was considered that the
      left ventricular dysfunction in ventricular pacing resulted from the absence of
      atrial contribution to ventricular filling, mitral regurgitation present and
      asynchronous ventricular contraction. No significant difference of cardiac
      performance was demonstrated by changing the site of ventricular pacing,
      suggesting that the mode of ventricular depolarization itself was not relevant to
      a decrease in cardiac performance.

PMID- 1013997
TI  - Combined liver-spleen-kidney scintigraphy and subsequent subtraction of the
      kidney scintiphotograph in the evaluation of displaced kidney.
AB  - The displacement of kidney was studied by using the combined liver-spleen-kidney
      scintigraphy and the subsequent subtraction of the kidney scintiphotograph to
      leave the liver-spleen scintiphotograph alone. A suprarenal mass was shown as
      cold spot between the liver and right kidney on the combined study. When the
      liver scintiphotograph and kidney scintiphotograph were over-lapped and the
      differential diagnosis was difficult, the subsequent subtraction of the kidney
      scintiphotograph was useful in the diagnosis of the enlarged liver.

PMID- 1013998
TI  - Change of serum IgE concentration in asthmatic attack.
AB  - Thirty-two patients with clinical diagnosis of bronchial asthma were evaluated.
      Serum IgE levels, measured by the Phadebas IgE test, were clearly increased in
      the patients with asthmatic attack compared with those without asthmatic attack.
      When the patients were grouped according to the clinical grading of severity of
      asthmatic attack, the levels showed the significant elevation in proportion to
      the intensity of asthmatic attack and were higher in the group of severe attack
      or moderately severe attack than in the group of mild attack. When the serial
      determination of serum IgE concentration was performed during the clinical course
      of the patients, a high correlation was observed between the levels and the
      intensity of asthmatic attack.

PMID- 1013999
TI  - Histopathological findings of the ovaries in anovulatory women.
AB  - Wedge resection of the ovary was carried out in 45 anovulatory women to study the
      correlation between the degree of disturbance of ovulation and the
      histopathological findings. Polycystic ovary was always found in patients with
      anovulatory cycles. The ovaries in grade 1 amenorrhea showing withdrawal bleeding
      in response to gestagen alone belonged to the nonspecific type, polycystic type
      and sclerotic type. These histological changes were relatively mild in many
      cases. The ovaries in grade 2 amenorrhea showing withdrawal bleeding in response
      to estrogen and gestagen but not to gestagen alone belonged to the non-specific
      type, polycystic type, sclerotic type, atrophic type and streak type. Even within
      the same histological entity, the histological findings of the ovaries were more
      pronounced in grade 2 amenorrhea than in grade 1 amenorrhea. The patients with
      primary amenorrhea had only hypoplastic and aplastic ovaries with marked
      histological abnormalities.

PMID- 1014000
TI  - Biological characteristics of breast cancer in obesity.
AB  - Biological characteristics of breast cancer in obese patients were investigated
      in comparison with non-obese patients. 134 patients with breast cancer were
      divided into three categories; thin, normal and obese based upon the height and
      weight. Five-year survival rate was 55.6% in the obese patients, whereas it was
      79.9% in the non-obese patients including thin and normal subjects. A cause for
      unfavorable prognosis in the obese patients with breast cancer was clinically and
      histologically investigated. It was found that in the obese patients primary
      tumor, regional lymph node engorgement and clinical stage were relatively
      advanced, scirrhous carcinoma was predominant ( 46%), tumor margin was more
      infiltrattive (gamma type 64%), the incidence of vascular involvement was high
      (73%), lymph node metastasis was also frequent (58%) and nuclear grade was low.

PMID- 1014001
TI  - Biotransformation of methylmercury in vitro.
AB  - Inorganic mercury formation from methylmercury by the mouse liver and kidney was
      studied in vitro. With chopped liver or kidney, inorganic mercury was formed from
      added methylmercury, but when the tissue was homogenized, the activity was
      diminished. Equimolar addition of selenium had no effect on the reaction.

PMID- 1014002
TI  - Extraction of erythrocyte membrane proteins by sulfhydryl inhibitors.
AB  - Human red cell membrane proteins were extracted by incubation of the ghost with
      hypotonic phosphate buffer (pH 7.4), N-ethylmaleimide and p-hydroxy
      mercuribenzoate. In paroxysmal nocturnal hemoglobinuria (PNH), hereditary
      spherocytosis (HS) and hereditary elliptocytosis, the amount of proteins
      extracted by these procedures was significantly less than the amount extractable
      from the ghost of normal and aplastic anemia red cells. Polypeptide patterns of
      red cell membranes in these hematological disorders were essentially similar to
      those of normal ghosts. Analysis of the supernatant by SDS polyacrylamide gel
      electrophoresis revealed that this reduction was mainly due to the reduced amount
      of peripheral proteins extracted. The extraction of peripheral proteins by
      sulfhydryl reagents was accompanied by shape changes resulting in the formation
      of membrane vesicles, suggesting an important role of peripheral proteins in the
      maintenance of ghost shape. It is also suggested that qualitative abnormalities
      of peripheral proteins such as altered reactivity to sulfhydryl reagents and/or
      strong binding to the membrane are present in PNH, HS and hereditary
      elliptocytosis red cells.

PMID- 1014003
TI  - Determination of intrapenial blood volume using 99mTc-labeled autologous red
      blood cells.
AB  - In 17 impotent patients, radioisotope penography was performed using 99mTc-red
      blood cells (the patient's own red blood cells labeled with 99mTc) for the
      quantitative analysis of intrapenial blood volume. A visual sexual stimulation
      (VSS) was given to the patient after injecting the 99mTc-red blood cells.
      Patients showing a complete erection had their intrapenial blood volumes 4.2-11.2
      times greater than before VSS (mean increase, 8.0 times). In cases of incomplete
      erection after VSS the intrapenial blood volumes were 3.3-7.0 times greater than
      before VSS (mean increase, 4.9 times). In cases showing a gentle rise in their
      penogram curves without evidence of an erection, intrapenial blood volumes after
      VSS were 2.0-3.3 times those before VSS (mean increaae, 2.9 times). By contrast,
      in cases showing no response to the VSS or no rise in penogram curve, post-VSS
      increases in intrapenial pool of blood were very slight, slight, only 1.4-1.7
      times the original volume of blood.

PMID- 1014004
TI  - Glial and capillary density of the pontine white matter in swelling and atrophy.
AB  - A total of 48 autopsied brains were morphometrically examined for the relation
      between pontine geometry and structural parameters. In each case, the numerical
      density of neuroglial cells Nv(G) and the linear density of capillary network
      Lv(C) of the pontine white matter were determined stereologically from the counts
      of glial nuclear profiles and capillary transections per constant area of a
      histological section with a constant thickness. It was revealed that in general
      the glial numerical density increased with advancing atrophy and decreased with
      increasing swelling, whereas the capillary linear density remained fairly
      constant especially in the advanced stage of brain swelling. Further analysis of
      this relation using a model of pontine geometry has made it clear that the total
      capillary length in the swollen white matter increases probably at the expense of
      the capillary caliber as swelling advances. The changes in the ratio Lv(C)/Nv(G)
      under pathological conditions are emphasized and possible utility of classifying
      stages of acute brain swelling from a viewpoint of microvascular dimension is
      suggested.

PMID- 1014005
TI  - [Hormonal anovulation with a single monthly oral dose].

PMID- 1014006
TI  - A slide rule developed for the performance approximation of the copper kettle
      vaporizer. (2) Addition of scales for new anesthetic agents.

PMID- 1014007
TI  - Anomalous arrangement of the pancreaticobiliary ductal system in choledochal
      cyst.

PMID- 1014008
TI  - Surgical results of cervical spondylotic radiculomyelopathy observed for more
      than five years.

PMID- 1014009
TI  - Effects of prolonged perfusion time on the isolated perfused rat heart.

PMID- 1014010
TI  - Body burden of hexachlorobenzene and its effects on some esterases in tissues of
      young male rats.

PMID- 1014011
TI  - Teratogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in CF-1 mice.

PMID- 1014012
TI  - The nephrotoxic effects of cis-diammine-dichloroplatinum (II) (NSC-119875) in
      male F344 rats.

PMID- 1014013
TI  - Prevention of praseodymium-induced hepatotoxicity by silybin.

PMID- 1014014
TI  - Effect of acetylsalicylic acid on a toxic dose of acetaminophen in the mouse.

PMID- 1014015
TI  - Kinetics of cadmium transport in the isolated perfused rat liver.

PMID- 1014016
TI  - In vitro analysis of 2,2-bis(p-chloropheny) acetic acid (DDA) handling by rat
      kidney and liver.

PMID- 1014017
TI  - Acute cardiovascular effects of intravenous methanol in the anesthetized dog.

PMID- 1014018
TI  - 1,4-Dioxane and beta-hydroxyethoxyacetic acid excretion in urine of humans
      exposed to dioxane vapors.

PMID- 1014019
TI  - Species variation in response to dimethylhydrazine.

PMID- 1014020
TI  - Immunochemical studies on cobra venom toxins [proceedings].

PMID- 1014021
TI  - Phospholipase A2 of Formosan cobra venom [proceedings].

PMID- 1014022
TI  - Conformation of snake toxins [proceedings].

PMID- 1014023
TI  - Studies on anticholinesterase principle from Formosan cobra venom [proceedings].

PMID- 1014024
TI  - Characterization of a thrombin-like enzyme from Crotalus adamanteus (Eastern
      diamondback rattlesnake) [proceedings].

PMID- 1014025
TI  - The effect of snake venoms on snake erythrocytes [proceedings].

PMID- 1014026
TI  - Studies of the coagulant and anticoagulant principles of Formosan crotalid venoms
      [proceedings].

PMID- 1014027
TI  - Mechanism of action of cobra cardiotoxin [proceedings].

PMID- 1014028
TI  - The chemical synthesis of Taiwan cobra venom toxins [proceedings].

PMID- 1014029
TI  - Structure and function of cobrotoxin [proceedings].

PMID- 1014030
TI  - On the nature of "maculotoxin", a toxin from the blue-ringed octopus
      (Hapalochlaena maculosa).

PMID- 1014031
TI  - Nucleases of the oriental hornet (Vespa orientalis) venom sac extract--I. Acid,
      neutral and alkaline deoxyribonucleases and their pharmacological effects on cat
      blood in vitro.

PMID- 1014032
TI  - Mechanism of the acute pulmonary edema induced by intracerebroventricular
      injection of scorpion toxin (tityustoxin) in the unanesthetized rat.

PMID- 1014033
TI  - Anti-inflammatory effects of apamin.

PMID- 1014034
TI  - Cytochemistry of the venom-secreting cells of the scorpion, Palamnaeus
      bengalensis.

PMID- 1014035
TI  - Amino acid sequence of pelamitoxin a, the main neurotoxin of the sea snake,
      Pelamis platurus.

PMID- 1014036
TI  - Preparation and pharmacokinetics of labeled derivatives of apamin.

PMID- 1014037
TI  - Postsynaptic and musculotropic effects of notexin, a presynaptic neurotoxin from
      the venom of Notechis scutatus scutatus (Australian tiger snake).

PMID- 1014038
TI  - Androgen metabolism by rat epididymis. 5. Metabolic conversion and nuclear
      binding after injection of 5alpha-androstane-3alpha, 17beta-diol, in vivo.
AB  - The pattern of androgenic metabolites in blood, muscle, caput and cauda
      epididymidis has been investigated in functionally hepatectomized 24 hours
      castrated rats, 3 hours after the intra-muscular injection of 200 muCi of 3H-3H
      3alpha-diol. Identification of the radioactive metabolites showed only negligible
      differences between the epididymal regions. In both caput and cauda the main
      metabolite was DHT (17beta-hydroxy-5alpha-androstane-3-one); 3alpha- and 3beta
      diol, androsterone (3alpha-hydroxy-5alpha-androstane-17-one), 5-A-dione (5alpha
      androsterone-3, 17-dione), delta16-3alpha-01 (kalpha-androst-16-en-3alpha-01),
      delta16-3beta-01 (5alpha-androst-16-en-3alpha-01) and delta16-3-one (5alpha
      androst-16-en-3-one) were also present. Androsterone and 3alpha-diol were the
      predominant metabolites in blood and muscle. No delta16 compounds could be
      detected and in constrast to epididymis, more than 50% of the radioactivity was
      associated with polar compounds. From determination of total radioactivity, it
      was seen that retention by epididymis varied from two to four times that of
      muscle. Purification and identification of the radioactivity associated with the
      nuclear fraction demonstrated that DHT was the only nuclear bound androgen. It is
      suggested from these results that at least one effect of 3alpha-diol on the rat
      epididymis is exerted through its conversion to DHT.

PMID- 1014039
TI  - Metabolites of estradiol-17beta in guinea pig uterus late in pregnancy.
AB  - The metabolism of estradiol-17beta by the guinea pig uterus late in pregnancy was
      studied in vivo and in vitro. Whole uteri were examined for estrogen metabolites
      one hour following an intravenous injection of [3H]-estradiol-17beta or uterine
      sections were examined after incubation for one hour at 37 degrees C in medium
      containing [3H]-estradiol-17beta. In both instances uterine tissue metabolized
      estradiol-17beta to five products; estrone, estrone-3-sulfate, 17beta-estradiol-3
      sulfate, estrone-3-glucuronide and 17beta-estradiol-3-glucuronide. Of the total
      radioactive products 11-43% were glucuronides, 17-26% were sulfates and 4-17% was
      estrone. These results indicate that the guinea pig uterus actively transforms
      estradiol-17beta into glucuronides and sulfates late in pregnancy.

PMID- 1014040
TI  - Simplified radioimmunoassay for aldosterone using antisera to aldosterone-gamma
      lactone.
AB  - A simplified, non-chromatographic method for aldosterone-gamma-lactone (2) radio
      immunoassay is described, using a high titer aldosterone-gamma-lactone antibody.
      This method takes six working hours for completion; the blanks are below the
      sensitivity of the assay (0-10 pg), and the intra and interassay coefficient of
      variation is 4.9% and 8.2% respectively. There is no significant variation with
      different plasma volumes assayed and the plot of added and assayed aldosterone
      gives a slope of 0.983. The negligible cross reactivity with other steroids and
      lactones eliminates the problem of interference by these substances.

PMID- 1014041
TI  - Phytoecdysones from Diplazium donianum.
AB  - From Diplazium donianum, makisterone A, makisterone D, and an unidentified
      stereoisomer of makisterone B have been isolated. The presence of two other
      unidentified phytoecdysones has been noted.

PMID- 1014042
TI  - Bile acids. LII. The synthesis of 24-nor-5alpha-cholic acid and its 3beta-isomer.
AB  - To aid in the identification of trihydroxy acidic metabolite(s) derived from beta
      sitosterol, 3alpha,7alpha,12alpha-trihydroxy-24-nor-5beta-cholan-23-oic acid was
      prepared and its methyl ester was treated with Raney nickel in boiling p-cymene
      to provide methyl 3-oxo-7alpha,12alpha-dihydroxy-24-nor-5alpha-cholanate, 3-oxo
      7alpha,12alpha-dihydroxy-24-nor-5beta-cholante and 3-oxo-7alpha,12alpha-dihydroxy
      24-norchol-4-enoate. The latter compound was synthesized from the 3-oxo-5beta
      derivative with SeO2 to provide a product with identical properties. Catalytic
      reduction of either saturated 3-oxo-derivative provided the appropriate 3,7,12
      triols isomeric at C-3. Results from gas liquid and partition chromatography,
      mass spectrometry, and otherr physical properties of the acids, their methyl
      esters and other derivatives are compatible with the assigned structures.

PMID- 1014043
TI  - Nuclear binding of the estrogen receptor in whole uteri.
AB  - In order to show whether the estrogen complex (ER) in the intact cell binds to
      some nuclear component or whether it is in free equilibrium between the cytoplasm
      and the nucleus, we incubated intact uteri under conditions which increased the
      ratio of nuclear to cytoplasmic ER. These conditions included (a) the use of
      sucrose at concentrations greater than 0.75 M, (b) ethanol at 7.5% to 10%, or (c)
      1 mM mercuric chloride or phenylmercuric acetate. Whereas (b) and (c) increased
      the ratio by preferentially denaturing the cytoplasmic ER, (a) caused ER to move
      from the cytoplasm into the nucleus by an undetermined mechanism. Uteri with a
      high ratio of nuclear to cytoplasmic ER were then washed, incubated in fresh
      "normal" incubation media, fractionated and the location of ER determined. If ER
      binding does occur in the nucleus, the high ratio of nuclear ER to cytoplasmic ER
      should be maintained, whereas if ER is in an equilibrium in the cell, ER should
      redistribute and re-establish the "normal" ratio. In all cases studied; i.e.,
      after pre-treatment with sucrose at different concentrations, ethanol at
      different concentrations and either mercuric chloride or phenylmercuric acetate,
      the ratio of nuclear to cytoplasmic ER remained high, suggesting that ER binds to
      some nuclear component in intact cells.

PMID- 1014044
TI  - Convenient large scale preparation of catechol estrogens.
AB  - 2-Hydroxyestrone, 2-hydroxyestradiol-17beta, 2-hydroxy-17alpha-ethynylestradiol,
      2-hydroxyestriol, 4-hydroxyestrone, 4-hydroxyestradiol-17beta, 4-hydroxy-17alpha
      ethynylestradiol and 4-hydroxyestriol are prepared on a preparative scale from
      the corresponding aminophenols using a new inverse oxidation procedure. By the
      synthesis described both the 2- and 4-hydroxylated estrogens are available in
      high yields.

PMID- 1014045
TI  - A non-chromatographic radioimmunoassay of progesterone in serum.
AB  - Convenient methodology based on separation of progesterone from alcoholic neutral
      steroids by means of a sulfation-procedure has been developed for the
      radioimmunoassay (RIA) of progesterone in male and female serum. When coordinated
      with our previously published non-chromatographic procedure for the RIA of
      estrone and estradiol in serum, all 3 seteroids can be determined in the same
      specimen. Validation of the procedure was based on: 1. Agreement between results
      obtained using ILC and sulfation to fractionate progesterone (r=0.98; b=0.86), 2.
      accurate recovery of different quantities of progesterone added to serum, 3.
      independence of the concentration of progesterone and volume of serum used for
      assay, 4. low procedural blanks (3.6 +/- 1.3 pg), 5. low intraassay (9.7 - 10.3%)
      and interassay (11.0 - 11.6%) variability and 6. correspondence of observed
      values for progesterone in male serum (108 +/- 20 pg/ml) and in female serum
      (follicular, 285 +/- 149 pg/ml; luteal, 3.46 +/- 1.45 ng/ml) with those reported
      previously by others.

PMID- 1014046
TI  - Hormonal regulation of LH stimulation of testosterone production in isolated
      Leydig cells of immature rats: the effect of hypophysectomy, FSH, and estradiol
      17beta.
AB  - Testosterone production in isolated Leydig cells from testes of immature and
      adult rats was stimulated by addition of LH in a dose dependent way.
      Hypophysectomy of adult rats had no influence on LH-stimulated testosterone
      production in isolated Leydig cells after 5 days. In contrast hypophysectomy of
      immature rats resulted after 5 days in an almost complete loss of LH sensitivity
      of isolated Leydig cells. Daily adminitration of FSH during 5 days starting
      immediately after hypophysectomy maintained LH responsiveness of isolated Leydig
      cells of immature rats. Also FSH administration starting on day 5 after
      hypophysectomy resulted in a restoration of LH responsiveness. Estradiol
      benzoate, injected simultaneously with FSH, abolished the FSH-induced LH
      responsiveness.

PMID- 1014047
TI  - Isolation, identification and quantitation of serum 5alpha-pregnane-3,20-dione
      and its relationship to progesterone in the pregnant mare.
AB  - 5alpha-pregnane-3,20-dione was isolated from pooled pregnant mare serum using
      Sephadex LH-20 column chromatography and identified by the use of
      radioimmunoassay, gas-liquid chromatography and gas-liquid chromatography-mass
      spectrometry analyses. 5beta-pregnane-3,20-dione was not cross-reactive with the
      radioimmunoassay system and was not detected by gas-liquid chromatography.
      Peripheral blood levels of progesterone and 5alphs-pregnane-3,20-dione were
      determined by radioimmunoassay in four Quarter Horse mares for the first 150 days
      of gestation. Progesterone and 5alpha-pregnane-3,20-dione declined from a range
      of 6 to 15 ng/ml at day 10 to a range of 2 to 8 ng/ml at day 40. After day 40
      there was an increase in progesterone and 5alpha-pregnane-3,20-dione
      concentration. Toward the end of 150 days of gestation progesterone tended to
      decline; whereas, 5alpha-pregnane-3,20-dione levels were maintained or increased
      to levels as high as 35 ng/ml. Neither source nor function of 5alpha-pregnane
      3,20-dione is known.

PMID- 1014048
TI  - Preparturient changes in plasma concentrations of estrone, estradiol-17beta and
      estradiol-17alpha in the fetal calf: effects of dexamethasone infusion.
AB  - The concentrations of total estrogens in fetal calf plasma were determined during
      a 6-10 day period immediately before delivery. Comparison was made between levels
      found in untreated calves and calves infused with dexamethasone at the rate of
      0.1, 1.0 and 10 mg/24 hours. In untreated calves the plasma estrone, estradiol
      17beta and estradio-17alpha levels remained relatively constant at 38 +/- 7 ng ml
      1 (mean +/- SEM n = 3), 46 +/- 6 ng ml-1 and 29 +/- 5 ng ml-1 respectively.
      Infusion with dexamethasone at 0.1 mg/24 hr (3 calves) and 1.0 mg/24 hr (3
      calves) was without dramatic effect on plasma estrogen levels. However, in one
      fetus infused with 10.0 mg/24 hr the dexamethasone treatment may have caused a
      transitory rise in the levels of all estrogens examined.

PMID- 1014049
TI  - [Histochemical determination of dehydrogenase activity in the heart depending on
      the time of death].

PMID- 1014050
TI  - [Profilographic study of the gash marks on bones].

PMID- 1014051
TI  - [Possibility of using the placental polymorphism of alkaline phosphatase in
      forensic serology].

PMID- 1014052
TI  - [Determination of the digitalis glycosides in cadaveric material by a photometric
      method based on the interaction reaction with 2,2',4,4'-tetranitrodiphenyl].

PMID- 1014053
TI  - [Detection of ethylene glycol in urine].

PMID- 1014054
TI  - [Forensic medical diagnosis of alcoholic intoxication].

PMID- 1014055
TI  - [Functional morphology of the adrenals in cases of sudden death from ischemic
      heart disease].

PMID- 1014056
TI  - [Evidence of tin compound poisonings in forensic chemical studies].

PMID- 1014057
TI  - [Gas chromatographic analysis of the alcohols in blood and urine by the absolute
      calibration method with sample tester].

PMID- 1014058
TI  - [Use of molselekt in chemical toxicological studies of hexobarbital and etaminal
      sodium].

PMID- 1014059
TI  - [Isolated rupture of the ileocolic artery in blunt trauma to the abdomen].

PMID- 1014060
TI  - [Lesions from screw propellers].

PMID- 1014061
TI  - [Complete avulsion of the head in an automobile injury].

PMID- 1014062
TI  - [Isolated closed injury of the cervical portion of the trachea].

PMID- 1014063
TI  - [Tangential lesion of the elbow joint in an automobile injury].

PMID- 1014064
TI  - Neurometric analysis of brain function.

PMID- 1014065
TI  - Handedness, speech pathology and hemispheric asymmetry.

PMID- 1014066
TI  - Schistosomiasis and carcinoma of the bladder: a critical appraisal of causal
      relationship.
AB  - The pathology of 154 cases of carcinoma of the urinary bladder diagnosed in
      surgical specimens in Ibadan is reviewed. Schistosoma haematobium-infections are
      found in association with all varieties of urothelial carcinoma. The majority of
      tumours in this and previously reported series from bilharzial and nonbilharzial
      underdeveloped regions presented in advanced stages. It is suggested that the
      preponderance of squamous cell carcinoma in these regions is a reflection of late
      clinical presentation. The evidence so far presented to support a causal
      relationship between schistosomiasis and carcinoma of the bladder is reviewed. It
      is concluded that such relationship is probably not true.

PMID- 1014067
TI  - Geographical distribution of amyloidosis in Papua New Guinea.
AB  - During an 11 year period 73 cases of amyloidosis were diagnosed at Port Moresby
      General Hospital as a result of histological examination of autopsy or biopsy
      material. No case of amyloidosis came from either the Highlands or North Coast
      regions although these two areas together accounted for 16% of the medical
      admissions at the hospital and made up a similar percentage of Port Moresby's
      Papua New Guinean population. Within the sub-district in which Port Moresby is
      situated there was a much higher incidence of amyloidosis in the inland, more
      sparsely populated, census divisions of the sub-district. Aetiological factors
      which may be related to the common occurrence of amyloidosis in Papua New Guinea
      are discussed in light of the observed geographical distribution of cases.

PMID- 1014068
TI  - Endemic elephantiasis of the lower legs in Rwanda and Burundi.
AB  - The distribution of non-filarial elephantiasis of the lower legs in Rwanda and
      Burundi in Central Africa has been studied in order to test the previous
      observation of an association between the disease and the volcanic rocks and
      soils on which the people live. Using the method of market counts, a total of
      26,602 adults were observed in 23 markets; 189 had elephantiasis. In addition,
      264 cases were observed in specially arranged clinics and a further 77 while
      travelling. Prevalence per thousand adults varied from 0.0 to 20.7. It was noted
      that the areas of high prevalence corresponded with the areas of volcanic lava. A
      differential market count at the edge of the red soils in two of these areas
      showed a raised prevalence among people living on these soils, similar to that
      observed in Ethiopia. The observations confirm that the disease occurs in
      barefooted people who dig in soil developed from volcanic rocks, under tropical
      conditions, at altitudes around 1500 m. It is suggested that the high proportion
      of iron and other transitional metals may be important as irritant or toxic to
      the lymphatic vessels of the legs after absorption.

PMID- 1014069
TI  - A tuberculin skin test survey in a rural Ghanaian population.
AB  - A study to determine the prevalence of positive tuberculin skin tests in a rural
      area of Ghana is described. Subjects over 14 exhibited the greatest percentage of
      positive reactions (40%), those under 15, less than 10 percent. Males had a
      higher percentage of positive reactions than females, which is consistent with
      the results of other tuberculin skin test studies. Prevalence of BCG scars was
      also studied as part of a village health survey medical examination. Overall BCG
      coverage was low (10%): the school age population, mose easily reached by mobile
      vaccination teams, had the highest rate of coverage (16%). There was a poor
      correlation between mothers' perception of children's BCG immunization status and
      the children's actual status determined during the medical examination, largely
      due to poor communication between immunization staff and the villagers. The
      authors conclude that BCG immunizations should be encouraged, particularly in
      children under 15, preferably via a mobile, mass campaign approach, with careful
      communication between medical staff and villagers.

PMID- 1014070
TI  - Volvulus of the sigmoid in Khartoum, Sudan.
AB  - Twenty-six cases of acute volvulus of the sigmoid in Khartoum Hospital are
      analysed. The condition accounts for 17.8 percent of all cases of acute
      intestinal obstruction. The majority of patients were from the Southern tribes
      whose diet contains a large amount of fibre. Of the different methods of surgical
      management simple operative detorsion and deflation gave the best results. The
      overall mortality rate was 23.1 percent.

PMID- 1014071
TI  - Preterm and other babies with low birthweights in Ibadan.
AB  - Earlier studies on the incidence of low birthweight babies were unanimous in the
      belief that this is a peculiarity of the developing countries, especially of the
      negro race. However, the more recent studies have shown that the differences in
      the incidence of low birthweights between the developed and developing countries
      might be due to other factors. In a study of birthweights in Ibadan, Nigeria,
      evidence was presented which showed that the level of socio-economic standards,
      rather than the peculiarity of geographical location or race, accounted for a
      high percentage of low birthweight babies. The various other factors associated
      with low birthweight babies in Ibadan were also highlighted.

PMID- 1014072
TI  - Platelet count in healthy full-term Nigerian neonates.
AB  - 633 platelet counts are reported on 338 full-term healthy Nigerian babies aged 1
      hour to 28 days. Platelet counts for the first week (207,000 +/- 72,000 cumm) are
      significantly lower (P less than .001) than in the subsequent 3 weeks (282,000 +/
      94,000 cumm). Platelet counts of 100,000-400,000/cumm during the first week and
      100,000-450,000/cumm during the rest of the neonatal period include 95% of the
      respective age groups of Nigerian infants studied and these ranges can therefore
      be regarded as standard for healthy Nigerian neonates. Platelet counts in
      Nigerian neonates are essentially similar to those reported elsewhere but
      significantly higher than in Nigerian adults.

PMID- 1014073
TI  - Lactose tolerance in adult Jordanian Arabs.
AB  - Lactose tolerance tests were performed in 56 male and female Jordanian Arabs who
      were permanently resident in the Hashemite Kingdom of Jordan. Forty three had a
      low rise in blood glucose and 36 had one or more symptoms after oral lactose.
      Lactose tolerance was not related to sex, age, milk or milk products consumption.
      The data presented confirm the few existing reports that the majority of Arabs,
      originating from the Mediterranean basin are hypolactasic and intolerant to
      lactose.

PMID- 1014074
TI  - Lactose intolerance in East Indians of Trinidad.
AB  - The incidence of lactose intolerance and by inference intestinal lactase
      deficiency was investigated by means of the oral lactose tolerance test in 30
      East Indians born in Trinidad but of Indian heritage. Twenty showed flat curves
      (67%) and twenty had cramps and diarrhoea following the lactose load (67%). In
      India milk consumption is less than in Trinidad. Since all subjects were of the
      same racial origin the findings are interpreted as suggesting that lactase
      deficiency among East Indians is inherited on a genetic basis.

PMID- 1014075
TI  - Serum cholesterol concentration in Arabs in Riyadh Saudi Arabia, and its relation
      to adult hypolactasia.

PMID- 1014076
TI  - Disorders which shorten life among Nigerians.

PMID- 1014077
TI  - Toxoplasma gondii haemagglutinating antibody titers in Indonesian goats.
AB  - Sera of 465 goats from several of the Indonesian islands were tested for indirect
      haemagglutinating (IHA) antibodies to Toxoplasma gondii. Titers greater than or
      equal to 1:16 were found in 24% of the animals with approximately 11% having
      titers of greater than or equal to 1:256. Sera from pigs, cows, water buffaloes
      and horses were also tested and only pig sera had IHA antibodies at titers above
      greater than or equal to 1:16. The possible role of goats in transmission of
      toxoplasmosis is discussed briefly.

PMID- 1014078
TI  - Filariasis in the Minahassa.
AB  - A survey concerning the occurrence of filariasis was carried out in Likupang, a
      village in the Minahassa, the norther tip of the Island of Celebes. We found four
      patients with elephantiasis of the leg. Only of people living in their
      neighbourhood proved to be positive for microfilariae of Brugia malayi. This
      result differs from surveys formerly carried out in whole Sulawesi, where locally
      microfilariae of Wuchereria bancrofti occurred next to those of B. malayi.

PMID- 1014079
TI  - [Age and the relationship between the concentration of phytohemagglutinin and
      lymphocyte blast-transformation in tissue culture].

PMID- 1014080
TI  - [Indications for amniocentesis for prenatal determination of fetal karyotype].
AB  - Analysis of the data from 13 centres of prenatal diagnosis in different countries
      revealed that 35 out of 1532 pregnancies where diagnostical amniocentesis was
      performed terminated in "spontaneous" abortions. The frequency of "spontaneous"
      abortions was found to be 2.28%. It was supposed that only those situations where
      a risk of the chromosomal disbalance in the fetus is above 2% may be regarded as
      the indications to amniocentesis for karyotype prenatal determination.

PMID- 1014081
TI  - [Autoradiographic study of the effect of adrenaline on cells entering the S
      period of the mitotic cycle in a primary culture of human embryonal fibroblasts].

PMID- 1014082
TI  - [Genetics of physiologic and pathologic aging].

PMID- 1014083
TI  - [Isolation of polymeric DNA from preserved fish gonads].

PMID- 1014084
TI  - [Assessment of the interrelationship between genotype and environment in breeding
      broiler chickens].

PMID- 1014085
TI  - [Types of hemoglobin in the sheep of Pamir].

PMID- 1014086
TI  - [Chromosome aberrations in the somatic cells of mammals evoked by chromium
      compounds].
AB  - It is established that potassium bichromate (K2Cr2O7) in chronic and acute
      poisoning evokes a significant increase in frequency of cells with chromosome
      aberrations in bone marrow of rats. Mutagenic effect of chromium compounds is not
      always in correlation with their toxic action. It is supposed that chromium
      compounds possess the properties of chemical mutagenes of delayed action.

PMID- 1014087
TI  - [Primary sex ratio in mammals].

PMID- 1014088
TI  - [Breeding with regard to a complex of amylase and ceruloplasmin genes in cattle
      and means of determining it].

PMID- 1014089
TI  - [Genetic polymorphism of blood proteins and indications of weight gain in young
      cattle].

PMID- 1014090
TI  - [Effect of caffeine in different tissues of Coreopsis tinctoria Nutt].

PMID- 1014091
TI  - [Genetic control of the wheat gliadin of T. aestivum (L.) Chinese spring
      variety].

PMID- 1014092
TI  - [Dwarf form of buckwheat].

PMID- 1014093
TI  - [Structure of anther wall cells of wheat plants with male sterility induced by 2
      chlorethylphosphonic acid].

PMID- 1014094
TI  - [Possibility of obtaining barley polyploids using acenaphthene and its
      derivatives].

PMID- 1014095
TI  - [Relationship between electrokinetic properties of cell nuclei, growth intensity
      and the level of natural and induced mutagenesis].

PMID- 1014096
TI  - [Production of a new form of fine-fiber cotton with improved fiber quality under
      the influence of a chemical mutagen].
AB  - A new form of cotton Mutant-1 was studied which is gymnospermous and is notable
      for an accelerated opening of bolls. This new form resulted from the effect of
      chemical mutagene HII-83 on hybrid population 5012 F4 from crossing the
      varieties2II3 X 5476II. The mutant differs essentially from the starting hybrid
      and all the more from the starting parental varieties in high productivity and
      quality of fibre and in certain quantitative and qualitative indexes.

PMID- 1014097
TI  - [Specificity and the mechanism of action of dimethylsulfate in the mutation
      process].

PMID- 1014098
TI  - [Ultrastructural transformation of guinea pig hepatocyte nuclei 2.5 hours after
      partial hepatectomy].
AB  - Ultrastructural changes of guinea-pig hepatocytes activated by partial
      hepatectomy were investigated in the period preceding the intensification of
      premitotic synthesis of protein and DNA, i. e. 2.5 hours after the operation,
      when the maximal increase of Acridine orange binding by DNP of these cells
      occurs. A disarrangement of the strand-like distribution patterns of condensed
      chromatin and margination of membrane-bound condensed chromatin was found.
      Morphometric analysis has shown some decrease of area occupied by condensed
      chromatin not bound with membrane and perinucleolar chromatin, and also a
      decrease in the number of isolated clumps of this chromatin. These finding may
      suggest some chromatin decondensation. At the same time, the condensed chromatin
      of most of hepatocytes reveals a righter packing of DNA fibrils. The nucleoli of
      activated hepatocytes increase in size and have a welll developed nucleolonemic
      structure and granular component; these pecularities corresponding to a high
      level of nucleolar RNA synthesis.

PMID- 1014099
TI  - [Different types of secondary degeneration of visual nerve endings in the
      midbrain tectum of the steppe turtle].
AB  - Along with the commonly known patterns of terminal destruction ("dark", "light",
      "neurofilamentous"), new types of changes have been revealed, referred to as
      "vesicular" and "glycogen" trasformation types. Vesicular transformation which
      may develop according to the dark or light type is characterized by a sharp
      deformation of synaptic vesicles; glycogen transformation is distinguished by
      agglutination and disappearance of synaptic vesicles, the inside of the terminal
      being filled up with glycogen granules. Ultrastructural differences of the
      terminal degeneration process in different groups of nerve fibers reflect the
      morpho-functional heterogeneity of the retina ganglion cells and of their axons.

PMID- 1014100
TI  - [Laminar analysis of neuronal ultrastructure in the midbrain tectum of the steppe
      turtle].
AB  - A layer-to-layer study of the neuronal ultrastructure in the mesencephalic optic
      centre of T. horsfieldi has been made, the results being compared to those of
      similar experments with Emys orbicularis L. Neurons of the efferent type (layers
      IV, V), in contrast to short axon elements (layers, I, 22) are characterized by a
      greater amount of cytoplasm and by a variety of cytoplasmatic organelles. A few
      morphological types of neurons are distinguished: light, dark and neurons with a
      light nucleus and a dark cytoplasm. In two systems of horizontal neurons dark
      cells predominate to be assumed as being an independent morphofunctional neuronal
      type. In contrast to E. orbicularis, the neurons of T. horsfieldi show a large
      amount of axo-somatic synapses on the surface, and a deficiency in spiny
      outgrowths, both on the apical and basal dendrites.

PMID- 1014101
TI  - [Local unscheduled DNA synthesis following irradiation of a portion of mitotic
      chromosomes or interphase nucleus with UV microbeam].
AB  - Part of mitotic chromosome sets of the metaphase or anaphase SPEW mammalian cells
      were irradiated with an ultraviolet microbeam, and the subsequent incorporation
      of H3-thymidine into the postmitotic daughter nuclei was studied by
      autoradiography. The located areas of the unscheduled DNA synthesis were detected
      in these nuclei. This synthesis was likely to be due to repair process at the
      sites of postmitotic localization of the irradiated chromosomes. It is suggested
      that the selective chromosomal labeling induced by microirradiation could be
      employed in studying patterns of chromosome localization in the interphase
      nuclei. Local inhibition of the replicative DNA synthesis and local stimulation
      of the unscheduled DNA synthesis were observed after a partial microirradiation
      of the interphase nuclei. This unscheduled DNA synthesis was unaffected by
      hydroxyurea at concentration which inhibited normal DNA synthesis.

PMID- 1014102
TI  - [Chromosome aberrations induced by fortrin in human lymphocytes in cultures and
      in vivo].
AB  - Chromosome aberrations in human lymphocytes in vitro and in vivo were studied
      after the treatment with the five-functional alkylating agent photrine (an
      original Soviet antitumour drug). In concentrations above 10-7 M photrine caused
      chromosome breaks in vitro at 4.6.10-4 M completely diminished the mitotic
      activity in cultured cells. The aberrations were presented almost exclusively as
      single and paired fragments occasionally distributed among the chromosomes. In
      three patients treated with photrine cells with aberrative karyotypes ranged
      within 14-37.5%.

PMID- 1014103
TI  - [Several cytologic changes in traumatized kidneys wrapped in a cellophane sheet].

PMID- 1014104
TI  - [Cytophotometric analysis of phases in the cell cycle of mouse thymocytes].

PMID- 1014105
TI  - [Effect of the dose of estradiol and long-term administration of the hormone on
      the proliferative activity of the epithelium of the cavity, glandular epithelium
      and stroma of the white rat uterus].
AB  - The duration of S-sphase of the cell cycle in uterine epithelial and stroma
      tissues of ovariectomised rats, treated with two doses of estradiol-17 beta for 4
      days, was estimated by the double labeling technique using H3 -and C14-thymidine.
      Estrogen treatment induced cyclical changes of S-phase duration in the uterine
      cell compartments, with maximal values at 72 and 24 hours for 1mcg and 1 mg of
      estradiol. resp. The high dose of estradiol induced five-fold reduction of the
      mitotic and labeling indices in luminal epithelium in contrast to the effect of
      the low dose. In the rat glandular epithelium and stroma cells mitotic and
      labeling indices are not influenced by eith of the estrogen dosis.

PMID- 1014106
TI  - [Accumulation of Gerin carcinoma cells in phase G2 of the mitotic cycle under
      hyperglycemic conditions].

PMID- 1014107
TI  - [Recording of azimuthal characteristics of the polarized fluorescence of
      microstructures using a semi-wave plate].
AB  - We have suggested and grounded theoretically application of lambda/2 plate for
      the registration azimuth characteristics (AC) of polarized fluorescence of
      microstructures. Proper device of polarization microfluorimeter has been worked
      out. Application of this device in case of transmitted light illumination has
      allowed to record AC of a very small objects (up to 1 mkm) and add to a-curacity
      of measurements. In the case of incident light illumination one need to make
      achromatic lambda/2 plates.

PMID- 1014108
TI  - Chemoprophylaxis trial in Canadian Eskimos.
AB  - One hundred and two cases of inactive tuberculosis, 165 positive tuberculin
      reactors and 103 previous BCG vaccinated individuals showing large tuberculin
      reactions were placed on the completely supervised regimen consisting of
      isoniazid and ethambutol given three times a week. Over 90% of these individuals
      completed 18 months' treatment. There were no active cases of tuberculosis among
      the treated groups during the observation period averaging 34.8 months. The
      control groups consisting of 217 individuals had 9 cases of active tuberculosis
      giving an annual risk of developing the disease of 1.8 per 1000.

PMID- 1014109
TI  - Acquired resistance to rifampicin by Mycobacterium kansasii.
AB  - Two patients with Mycobacterium kansasii infection of the lung had organisms
      sensitive to rifampicin. Following treatment, essentially with rifampicin alone,
      the patients began to excrete organisms completely resistant to rifampicin. The
      ability of M. kansasii to acquire resistance to rifampicin during treatment has
      been clearly demonstrated. This reinforces the need to treat this infection with
      an adequate multiple drug regimen.

PMID- 1014110
TI  - [Gastric stump carcinoma after resection for benign gastric or duodenal ulcer
      (author's transl)].
AB  - 33 cases of cancer of the gastric stump after gastrectomy for peptic ulcer
      observed between 1963 and 1972 are reviewed. In 26 patients the average interval
      between operation and carcinoma detection was over 20 years. No cases of
      carcinoma occurred in less than 10 years. All patients came too late for surgery,
      since they had attributed their symptoms to the previous operation. The gradual
      increase in the gastric-cancer risk of operated patients with time suggests a
      continuous carcinogenic influence. Regurgitation of duodenal contents through the
      Billroth II anastomosis seems to be the most important cause of postoperative
      atrophic gastritis, which is now considered by many authors to be a condition
      predisposing to gastric cancer. Gastric resection patients should be regarded as
      a high gastric-cancer risk group. The periodic use of modern procedures for early
      gastric cancer detection in this group of patients is therefore justified.

PMID- 1014111
TI  - Effect of sulpiride on mammary tumor growth.
AB  - The daily subcutaneous injection of sulpiride produced increase tumor growth and
      decrease of survival in DBA/2 mice bearing a transplanted mammary gland tumor. It
      is proposed that sulpiride effect may be mediated by the augment of prolactin
      level in serum.

PMID- 1014112
TI  - Evaluation of the risk of multiple primaries in malignant cutaneous melanoma.
AB  - The evaluation of the risk of a second primary melanoma has been done on a series
      of 521 cases of malignant melanoma observed at the National Cancer Institute of
      Milan from September 1967 to December 1974. It has been found that a malignant
      melanoma patient is about 900 times more likely to have a second primary than an
      individual in the general population is likely to contract the disease. The risk
      is age and sex dependent.

PMID- 1014113
TI  - [In vitro development of macrophages from PHA-stimulated blood cultures in
      Hodgkin's disease and in chronic lymphocytic leukaemia (author's transl)].
AB  - Blood was cultured from 17 normal subjects, 28 cases of untreated chronic
      lymphocytic leukaemia (CLL) and 41 cases of Hodgkin's disease. Macrophages were
      not observed in PHA-stimulated cultures of normal subjects, of CLL or of 18 cases
      of Hodgkin's disease. The latter had an almost normal rate of lymphocyte blast
      transformation (70,2 +/- 7,2%).on the other hand, macrophages were numerous in
      PHA-stimulated cultures of 23 cases of Hodgkin's disease with a low blast
      transformation (28.4 +/- 13,7%). In Hodgkin's disease the development of
      macrophages in PHA cultures may be related to the lower blast transformation and
      cytotoxic activity of lymphocytes. In CLL the dilution of lymphocytes and
      monocytes by leukaemic B cells may account both for PHA unresponsiveness and low
      yield of macrophages in culture.

PMID- 1014114
TI  - [Clinical-statistical correlation in 286 cases of diffuse and intestinal
      carcinoma of the stomach (author's transl)].
AB  - Gastric carcinoma cases have been classified according to Lauren's system. The
      intestinal and diffuse histotypes are compared, and correlated with the
      epidemiologic data, type of operation and follow-up. The results show that total
      gastrectomy is indicated in diffuse carcinoma.

PMID- 1014115
TI  - [Criteria for applying target biopsy and histological features in the diagnosis
      of gastric cancer in situ (author's transl)].
AB  - A histological examination of samples of 131 chronic gastric ulcers, 9 polyps and
      12 cases of mucosal atrophy taken by means of a endoscope showed 3 border-line
      lesions and 4 early gastric cancers. The histological patterns of these lesions
      are described and the difficulty of histological diagnoses in early malignancy
      are emphasized.

PMID- 1014116
TI  - Early glial tumor metastases through a ventriculo-atrial shunt.
AB  - A girl of 12 with a pontine polymorphous astrocytoma diffusely metastasizing to
      the spinal cord leptomeninges suddenly died 20 hours after the insertion of a
      right ventriculo-atrial shunt. Many severely damaged glial neoplastic cells were
      found in the blood vessels of the lung and liver.

PMID- 1014117
TI  - [Radiological study of complications and recurrences of esophageal carcinoma
      after surgery (author's transl)].
AB  - 256 esophageal carcinoma patients subject to various surgical procedures were
      examined with a view to identifying as early as possible the complications and
      possible tumoral recurrences, early or late, at anastomosis level. The most
      caracteristic and frequent radiological features, especially of neoplastic
      recurrences are presented; the various morphological types are described and
      discussed and for the first time a radiographic classification is proposed,
      followed by a discussion of the criteria of differential diagnosis of these
      lesions, especially from postoperative perivisceritis. Correct identification and
      precise radiographic description of the early signs of neoplastic recurrence in
      the esophagogastric anastomoses make it possible to reoperate, at least in some
      patients.

PMID- 1014118
TI  - [Evaluation of 178 mediastinoscopies (author's transl)].
AB  - Of the 178 consecutive mediastinoscopies performed at the Istituto Nazionale per
      lo Studio e la Cura dei Tumori of Milan from 1967 to 1974 145 were performed for
      diagnostic purposes and 33 for the pre-operative evaluation of resectability in
      cases of proven lung carcinoma. Mediastinoscopy is a very useful procedure for
      obtaining a definite pathological diagnsis in indeterminate mediastinal and
      pulmonary lesions. In succases, mediastinoscopy should precede any attempt at
      therapy, as 1/3 primary mediastinal lymph node lesions are benign and about 30%
      of suspected mediastinal tumors or lymphomas are actually misdiagnosed lung
      cancers (mainly oat-cell carcinomas). As to the role of mediastinoscopy in the
      assessment of lung cancer resectability, the current view is that it plays a part
      together with tomography and bronchoscopy in the clinical staging of this
      neoplasm, but it is no longer relied upon alone. It is mandatory in every case of
      suspected or probable mediastinal invasion and the criteria for inoperability are
      the following: spread to high paratracheal or contralateral nodes, direct
      invasion of the mediastinal fat, fixity of the neoplasm to the trachea or
      vertebral bodies. In such cases mediastinoscopy will prevent a useless
      exploratory thoracotomy.

PMID- 1014119
TI  - [Alcohol infusion of the pituitary, high-dose medroxyprogesterone and their
      association as analgesics in advanced breast cancer (author's transl)].
AB  - The analgesic effects of alcohol infusion of the pituitary, high-dose
      progesterone and their association on chronic intractable pain in TxN+M+ breast
      cancer patients no longer responsive to combination chemotherapy, radiotherapy
      and hormone therapy are assessed. The antalgic effect of medroxyprogesterone
      proved to be more lasting than that of alcohol infusion of the pituitary.
      Moreover, 6 of the 20 patients treated with the former presented regression of
      the disease whereas none of those treated with alcohol did so.

PMID- 1014120
TI  - An analysis of 800 breast cancer patients relapsed after radical mastectomy.
AB  - The chronology of first recurrences, their topographic distribution and survival
      from mastectomy were retrospectively studied in a series of 800 mastectomized
      women with special reference to the relationship between these data and treatment
      delay, TN categories and free interval. Visceral metastases were more frequent in
      patients under 50 years, whereas local recurrences were more common in patients
      over 50. The average free interval was 26 months (over 5 years in 18% of cases)
      and seemed to be influenced little by the treatment delay or by tumor size; it
      was shorter in patients under 50 years and shorter still in patients with lymph
      node involvement at operation. A similar correlation exists between these
      parameters and survival. The 5 years survival rate of the 800 cases with
      recurrence was 52%, which is quite different from the rate generally indicated
      for surgical cases, and much higher than the rate for the natural history of
      untreated breast cancer. The survival rate in cases with first metastases
      confined to the soft tissues is much higher than in those with bone and/or with
      visceral metastases. The survival after recurrence proves to be significantly
      influenced by the length of the free interval, but much more by the presence or
      absence of regional lymph node involvement so that the lymph nodes status (N--or
      N+) turns out to be a prognostic item of primary importance, even after the onset
      recurrence.

PMID- 1014121
TI  - The effect of high molecular dextran on coagulation and metastes.
AB  - The intravenous injection of high molecular dextran (HMD), increased pulmonary
      metastases of the carcinosarcoma of Walker 256, from 35 per-cent of the control
      animals to 64 per-cent of the animals treated with HMD. A significant
      prolongation of the clotting time and prothrombin; and a decrease in fibrinogen
      levels platelets, hematocrit and factors II, V, VII and VIII were observed
      following the infusion of HMD. There was no obvious untoward side effect of HMD
      in any of the animals studies.

PMID- 1014122
TI  - [Cobalt therapy in the treatment of carcinoma of the oropharynx].
AB  - A clinical retrospective evaluation of 177 cases of carcinoma of the oropharynx
      treated with Cobalt therapy from 1959 to 1965 has been made. The analysis of long
      term results has shown that Cobalt therapy alone does not satisfactorily control
      carcinomas of oropharynx. In fact, less than 30% of the patients is still alive
      after 3 years. Survival is directly affected by the local extent of disease
      since, while the 5-year survival of T1 and T2 cases is respectively 26.8% and
      21.5%, only 6.5% of patients with T3 carcinomas is still alive after 5 years.
      Particularly disappointing is the survival rate in cases with mono- or bilateral
      involvement of neck nodes, since none of these cases are alive 2 years after the
      initial therapy. In 69.4% of the cases, treatment failure has to be attributed to
      minimal response or early recurrence of primary tumor, while lymph node relapses
      have been observed in more than 25% of the cases. To allow a detailed clinical
      evaluation of the results, the different regions of the oropharynx should be
      considered separately, since differences in clinical evolution of various
      carcinomas would call for a different therapeutic approach. The results of this
      study in oropharyngeal carcinomas, indicate that improvement of long term results
      may only be obtained through a multidisciplinary therapeutic approach.

PMID- 1014123
TI  - [Sarcoid type granuloma in lymph nodes with Hodgkin's disease].
AB  - Sarcoid type granuloma have been observed in lymph nodes with Hodgkin's disease.
      Several pathogenetic hypotheses have been considered, and finally the picture has
      been interpreted as the epithelioid form of Hodgkin's disease.

PMID- 1014124
TI  - Evaluation of mass screening programmes for cervical cancer in N.E. Scotland.

PMID- 1014125
TI  - Mass population screening for cervix cancer.

PMID- 1014126
TI  - Quality control in cytological screening for cervical cancer.

PMID- 1014127
TI  - Studies of response to cervical screening.

PMID- 1014128
TI  - Prevalence rates of cervical lesions in specifically defined areas.

PMID- 1014129
TI  - Oxford sliding scale recall scheme.

PMID- 1014130
TI  - Problems in the construction and interpretation of screening programmes.

PMID- 1014131
TI  - Specific problems in a screening programme.

PMID- 1014132
TI  - The evaluation of mass screening programmes for cervical cancer.

PMID- 1014133
TI  - Evaluation of mass screening for cervical cancer in Ljubljana region.

PMID- 1014134
TI  - Evaluation and costing of mass screening programmes for cervical cancer.

PMID- 1014135
TI  - Acquisitions and further progress in mass screening for cancer.

PMID- 1014136
TI  - [Effect of several surface-active substances on the biological and mechanical
      properties of a catalase monolayer].
AB  - It is found out that surface pressure of catalase monolayers increases when some
      medicinal surface-active agents are added to its substrate, while its enzymic
      activity decreases depending on the increase of surface activity of the medicinal
      substance. Catalase monolayer viscosity grows with a decrease in the area. The
      viscosity decreases with a rise in the dimedrol concentration in the substrate.
      The same is recorded for the shear module. As to the shear stress characterizing
      the strength of the monolayers it decreases with the addition of medicinal
      substances. This change in rheological properties of the catalase monolayer
      evidences for its structural destruction with an increase in the mixed monolayer
      pressure.

PMID- 1014137
TI  - [Two forms of alkaline phosphatase and 5'-nucleotidase in the serum of persons
      with jaundice of different origin].
AB  - Distribution of the alkaline phosphatase and 5'-nucleotidase activity was studied
      in blood serum by means of gel filtration through Sephadex G-200 with jaundices
      of different origin. Both enzymes have two forms differing in the molecular
      weight, 5'-nucleotidase presenting mainly a high-molecular form in contrast to
      alkaline phosphatase. This form activity for both enzymes is higher with
      obturative jaundices as compared to liver cirrhosis and virus hepatitis. The
      results of incubating sera with desoxicholate and the subsequent gel filtration
      in its presence, as well as polyacrylamide gel electrophoresis of butanol
      extracts of the fractions containing high-molecular fragments, evidence for the
      fact that these fragments are lipoproteid complexes.

PMID- 1014138
TI  - [Effect of excess D,L-tryptophan on the level of aminoacylation of tRNA by 14C
      tryptophan].
AB  - The effect of the D,L-tryptophan excess in the rat organism was studied as
      applied to the level of amino acylation of tRNA by 14C-tryptophan. It is
      established that the introduction of tryptophan for three days in doses of 50 and
      75 mg per 100 g of the living weight evokes a 24 and 40% decrease, respectively,
      in the level of amino acylation of the rat livel tRNA by 14C-tryptophan. The
      ability of accepting 14C-tryptophan in total preparations of the experimental
      rats liver tRNA considerably lower as compared to norm. A short-term heating in
      the presence of magnesium ions partially restores their decreased acceptor
      ability. This gives ground to suppose that the molecules of tRNAtr in the total
      preparation of the rat liver tRNA with a great tryptophan excess in the organism
      partially change their conformation and this is one of the reasons of the
      decrease in the level of tRNA amino acylation by 14C-tryptophan. The decrease in
      the protein synthesis at the first stage with the presence of a great tryptophan
      excess in the organism is evident to be also connected with the inhibition of
      tryptophanyl-tRNA-synthetase activity.

PMID- 1014139
TI  - [Physico-chemical properties of uterine smooth muscle actomyosin].
AB  - The actomyosin complex of human myometrium has a low Ca-activated ATPase activity
      (0.007-0.012 mu mole H+ per 1 mg protein for 1 min), small degree and rate of
      superprecipitation. Transition to the state of pregnancy is accompanied by
      considerable changes in the physicochemical properties of the myometrium
      actomyosin. ATPase activity is 5-10 times as high and the rate of
      superprecipitation rises, particularly after the increase in the calcium
      concentration. The content of nucleic acid in the actomyosin complex decreases
      and D280/D260=1.1. The intensity of the actomyosin fluorescence at the pregnant
      state is more than twice as high.

PMID- 1014140
TI  - [Glutathione peroxidase and glutathione reductase activity in rat liver following
      administration of vitamin E and methionine].
AB  - A single introduction of vitamin E and D,L-methionine to rats kept on the
      vivarium ration or their addition to protein-free diet separately does not affect
      the glutathionperoxidase and glutathionreductase activities in the liver. A
      simultaneus introdyction of the vitamin and methionine causes an increase in the
      glutathionperoxidase activity, without changing the glutathionreductase activity.
      Vitamin E prevents from increasing the glutathionperoxidase and
      glutathionreductase activities due to selenium. Propyl gallate produces no such
      effect.

PMID- 1014141
TI  - [Electrophoretic fractions and NH2-terminal amino acids of high-molecular tryptic
      fragments of fibrinogen and fibrin].
AB  - The electrophoretic and NH2-terminal analyses were performed for D and E
      fragments obtained by tryptic digestion of bovine fibrinogen and fibrin under
      various conditions. The preparations of fragment D were heterogeneous, they were
      separated by polyacrylamide gel electrophoresis into a number of electrophoretic
      components with molecular weight ranging from 65 000 to 85 000. NH2-terminal
      analysis revealed from 6 to 8 NH2-terminal amino acids: Ser, Gly, Thr, Asp, Gly,
      Lys, Gln, Asn. Their composition and quantitative ratios were found to vary
      depending on the conditions of the fragment D production. The electrophoregrams
      showed that with Ca++ in the medium the enzymatic splitting of fibrinogen was
      limited. Fragment D obtained from fibrinogen without Ca++ was electrophoretically
      rather similar to that obtained from fibrinogen at Ca++ optimal concentration.
      Taking into consideration a very high specific anti-coagulational activity of
      these two fragment D preparations, one may conclude that both the polymerized
      state of protein molecules and the presence of Ca++ stabilize the specific
      molecular structure, that favorus the preservation of specific inhibitory
      activity in fragment D. According to the NH2-terminal analysis data, fragment E
      derived from fibrinogen hydrolyzed in the presence of Ca++ optimal concentration
      is also heterogeneous. The following amino acids were found: Tyr, Lys, His (main
      ones) and Gly, Ser, Thr, Val (minor ones). As to molecular weight determined by
      electrophoresis, fragment E appears to be homogeneous.

PMID- 1014142
TI  - [Content of polyribosomes and poly-A-containing RNA in rat liver during
      hepatocarcinogenesis induced by diethylnitrosamine].
AB  - The contents of total polyribosomes and the ratio of free to membrano-bound
      polyribosomes as well as the number of poly(A)-containing RNA in cytoplasm and in
      two classes of polyribosomes of the liver were studied in rats chronically
      treated with diethylnitrosamine. A decrease in the number of total polyribosomes
      and changes in the ratio of free to membrane-bound polyribosomes toward a
      decrease of the latter were found within the whole period of carcinogenesis. The
      absolute amount of the free polyribosomes per 1 gr of the liver tissue did not
      differ significantly from the normal values but the number of the membrane-bound
      polyribosomes in the treated animals was 2-2,5 times as low. The amount of
      poly(A)-containing RNA in the postmitochondrial fraction increased and decreased
      in free polyribosomes. A redistribution of the templates by free and membrane
      bound polyribosomes in cytoplasm of the hepatocytes during hepatocarcinogenesis
      due to the disturbances in the equilibrium between these two classes of
      polyribosomes is suggested.

PMID- 1014143
TI  - [RNA concentration in DNA preparations from animal tissues (quantitative analysis
      of an alkaline hydrolysate)].
AB  - Two methods are compared for estimating the RNA admixture in preparations of DNA
      isolated from mammalian tissues. The RNA content in alkaline hydrolyzates of DNA
      as determined by the spectrophotometric method is found to be from 2 to 5 times
      higher than that estimated by means of the colour orcinol reaction. Possible
      reasons of such a difference are discussed. Attempts are made to find out the
      optimal conditions for isolating RNA from DNA preparations.

PMID- 1014144
TI  - [Educational simulation experiment for teaching examination of the locomotor
      system].

PMID- 1014145
TI  - [Evaluation of patellar position by tangential x-ray visualization].

PMID- 1014146
TI  - [Ewing's sarcoma].

PMID- 1014147
TI  - [Marfan's syndrome: nosologic study].

PMID- 1014148
TI  - [Screening for scoliosis in schools. Study on 14,886 x-rays].

PMID- 1014149
TI  - [Early postoperative ambulation in the treatment of genetic scoliosis. I. Technic
      of application of the plaster cast].

PMID- 1014150
TI  - [Posterior approach in arthroplasty for total hip prosthesis].

PMID- 1014151
TI  - [175 total hip prostheses at the Hotel-Dieu de Montreal: an analysis of
      complications].

PMID- 1014152
TI  - [Arthroplasty of the knee (Marmor's prosthesis)].

PMID- 1014153
TI  - [Review of the 1st 255 cases of scoliosis operated on at the Hopital Sainte
      Justine by Harrington's technic].

PMID- 1014154
TI  - [Circumferential excision of an aneurysmal cyst of the spinal column].

PMID- 1014155
TI  - [Crossed dislocation of the elbow in children. Unusual complication].

PMID- 1014156
TI  - [Replacement of the external femoral condyle with the pediculated patella].

PMID- 1014157
TI  - [Study of the action of calcitonin on the kidney].

PMID- 1014158
TI  - [Mimicry in coronary disease].

PMID- 1014159
TI  - [Tensilon tonography in the diagnosis of myasthenia gravis].

PMID- 1014160
TI  - [Antipsychiatric legal activism in the United States].

PMID- 1014161
TI  - [Simplified shunting technic in surgery of the aortic arch].

PMID- 1014162
TI  - [Neurochemical changes in discrete regions of the brain of rats after
      autostimulation in the mesencephalic tegmentoventral region].

PMID- 1014163
TI  - Binding of proteins to mouse blastocysts after the attachment stage of
      implantation.
AB  - Experimentally delayed mouse blastocysts were activated to implant by exogenous
      estradiol and after varying duration of estrogen influence, the blastocysts were
      flushed out from the uterine horns. Then they were incubated in the cold with
      different, 125I-conjugated proteins and the amount of protein bound to the
      blastocysts was determined by radioassay. Three radiolabelled proteins: human
      serum albumin (125I-HSA), human serum transferrin (125I-HST) and normal rabbit
      IgG (125I-RIgG) were tested and it was found that the uptake of each protein
      markedly increased between 14 and 24 hours of estrogen-activation. It was
      possible to partially block the binding of 125I-HSA and 125I-RIgG with the
      respective unlabelled protein. Unlabelled RIgG could also partially block the
      uptake of 125I-HSA whereas HSA did not impede the binding of 125I-RIgG. During
      delay of implantation the protein binding was low and approximately the same as
      after 14 hours of activation. However, at 18 and 24 hours of activation protein
      uptake increased gradually. Raising the incubation temperature from 0 to 37
      degrees C did not significantly influence the protein binding capacity of the 24
      hour-activated blastocyts. Whole blastocyst autoradiography indicated that the
      labelled protein was heavily bound in patches, preferentially located in the
      abembryonic half of the postattachment blastocysts. It is assumed that the
      binding of protein to abembryonic trophoblast cells of the implanting blastocyst
      can be attributed to the presence of protein receptors on the surface of these
      cells.

PMID- 1014164
TI  - Atrial activity in atrial fibrillation after intravenous verapamil.

PMID- 1014165
TI  - Detection and characterization of hyperlipoproteinaemia in middle-aged men.
AB  - Serum lipoprotein (LP) concentrations were determined and LP patterns were
      classified in 261 middle-aged men, recruited from a health examination survey,
      with serum lipid values above the 80th percentile of the same population.
      Individuals with hyperlipoproteinaemia (HLP) and normolipidaemic controls were
      characterized also regarding family history of cardiovascular disease, socio
      economic factors and clinical and laboratory variables. Subjects with HLP type IV
      V and IIB were overweight and showed hyperuricaemia and hyperinsulinaemia
      compared with normolipidaemic controls and subjects with HLP type IIA. The latter
      showed elevated erythrocyte sedimentation rate. In spite of being overweight,
      subjects with HLP type III showed normal fasting values of insulin and uric acid
      in serum and normal early insulin response to intravenous glucose. The glucose
      tolerance did not differ significantly between the groups. Men with HLP types IV
      V had predominantly sedentary occupations, in contrast to those with type IIA.
      There were significantly more smokers in the groups with HLP type IIB and IV-V
      than in the control group. Thus, individuals with different types of HLP tend to
      show different metabolic profiles but also different socioeconomic and clinical
      patterns, suggesting that exogenous factors are of importance in the expression
      of the LP abnormalities.

PMID- 1014166
TI  - Acute myopericarditis. A long-term follow-up study.
AB  - A follow-up study was made of 29 patients aged 21 to 45 years, some 15-158 months
      after acute myopericarditis. The mean follow-up period was 72.9 months. The
      follow-up investigation included recording of history, physical examination,
      laboratory tests, radiologic examination of the heart and lungs and
      electrocardiography. All but one of the patients were fit for fulltime work. Nine
      had residual cardiac symptoms, but the physical examination was negative in all
      but 2 of them. One patient had chronic cardiac insufficiency and hepatic
      enlargement. Another had sinus tachycardia and cardiac enlargement of moderate
      degree and impaired working capacity in relation to heart size. Cardiac murmurs
      without clinical significance were audible in three cases. The resting ECG was
      pathologic in only 6 cases. Orthostatic ECG evoked ECG abnormalities in 6 more
      cases. Exercise tolerance tests showed reduced working capacity in relation to
      heart volume in 5 of the 29 cases (17%). Four of these 5 patients had cardiac
      enlargement. There was thus good correlation between increase in heart volume and
      reduction of physical capacity. The prognosis in regard to cardiac function was
      good, as was also found in other comparable series in which the observation time
      was somewhat shorter.

PMID- 1014167
TI  - Dimensions of the rabbit tenuissimus muscle.
AB  - A study of the physical dimensions of the rabbit tenuissimus muscle is described
      and compared with previous work on the same muscle from the cat. The muscle in
      the rabbit was found to be larger than in the cat, but was consistent in its
      dimensions and suitable for use as a model for microvascular research.

PMID- 1014168
TI  - The effect of digitalis on regional ischaemia of the rat small intestine.
AB  - Research in recent years has shown that under certain conditions digitalis has a
      strong vasoconstrictive effect in the splanchnic region. This may imply that in
      cases of mesenteric ischaemia, digitalization may inhibit a collateral
      circulation necessary for restoration of the intestinal function. In this
      investigation the effect of digitoxin on the exchange circulation of the small
      bowel mucosa was studied in rats with induced regional ischaemia of the
      intestine. On analysis 30 min after establishment of the ischaemia a
      statistically significant negative effect of digitoxin was observed.

PMID- 1014169
TI  - Preliminary report on angiography with polymeric contrast agents in rabbits and
      dogs.
AB  - Polymeric, water-soluble, iodine-containing contrast agents have been synthesized
      and tested in renal angiography and thoracic aortography in rabbits and in
      femoral arteriography in dogs. Good filling of the arteries and also of the veins
      was obtained.

PMID- 1014170
TI  - Familial ovarian carcinoma.
AB  - Familial aggregation of patients with ovarian carcinoma is unusual. A family with
      four affected members in three consecutive generations is described. The tumors
      were all of the serous papillary adenocarcinoma type. The pattern of appearance
      of the malignant disorder in the present family may be explained as the result of
      transmission of a dominant mutant autosomal gene. The future long term management
      of such a family might include prophylactic oophorectomy in certain family
      members, and possibly selective terminations of pregnancies with female fetuses
      in high-risk women.

PMID- 1014171
TI  - The fluid double polar-nonpolar-polar leaflet model for biological membranes.
AB  - A model for biological membranes is proposed according to which the plasma
      membrane consists of two functionally different polar-nonpolar-polar leaflets
      separated by a polar space. The binding of water-soluble proteins, integral
      lipoproteins and spanning proteins to a biological membrane as well as possible
      conformations of interphase peptides partitioned between polar and nonpolar
      layers are discussed. A model for the diffusion of water soluble proteins across
      nonpolar layers of a membrane is described. Three complete biological membranes
      containing two leaflets and an inter-leaflet space are defined. These are: 1: The
      inner nuclear membrane + the perinuclear space and the endoplasmatic cisternae +
      the outer nuclear membrane and the endoplasmatic reticulum, 2: the innner
      mitochondrial membrane + the mitochondrial intermembraneous space + the outer
      mitochondrial membrane and 3: the cytoplasmic leaflet of the plasma membrane + an
      intramembraneous space in the plasma membrane + the outer leaflet of the plasma
      membrane.

PMID- 1014172
TI  - Uromucoid in the rat: its isolation, localization in the kidney and concentration
      in the urine.
AB  - Based on the finding that rat uromucoid cross reacts with antihuman uromucoid,
      rat uromucoid was isolated by means of immune absorption chromatography. Using a
      monospecific antiserum obtained with the use of this preparation, uromucoid was
      shown to be present in the distal tublues of the kidney. A quantitative
      immunological determination was made from the urine of 30 normal rats.

PMID- 1014173
TI  - A contribution to the formation mechanism of calcium oxalate urinary calculi. I.
      Stabilising urinary constituents in the formation of weddellite.
AB  - 25 to 30% of calcium oxalate urinary calculi consist of the metastable Weddellite
      crystal phase. By fractionation of urine it was found that mineral substances are
      stabilising factors. The stability was checked in dry condition at room
      temperature at 38 degrees C and at 110 degrees C. These results could be
      confirmed by precipitation from synthetic solutions. Mg, Zn, Ni, Co, Mn and Cu
      individually, and above all in combination, promote the formation of Weddellite.
      The formation of mixed crystal phases must be considered one of the main factors
      for the stabilisation of Weddelite in the urinaty calculus.

PMID- 1014174
TI  - [Hydrodynamic indices and visual functions in primary compensated glaucoma].

PMID- 1014175
TI  - [Scleral angle construction (4 years of clinical experience)].

PMID- 1014176
TI  - [Hypotonia of the eve following surgery of glaucoma].

PMID- 1014177
TI  - [Models and experimental therapy in acute rises of intraocular pressure].

PMID- 1014178
TI  - [Anatomical features of the eye in patients with primary glaucoma].

PMID- 1014179
TI  - [State of the other eye in patients with acute attack of glaucoma].

PMID- 1014180
TI  - [Examination of hypotensive and miotic effects of different pilocarpine solutions
      (experimental investigations)].

PMID- 1014181
TI  - [Experimental homotransplantation and reimplantation of the eyeball].

PMID- 1014182
TI  - [Ultrasound effect on the corneal epithelium].

PMID- 1014183
TI  - [Present state and trends in glaucoma research].

PMID- 1014184
TI  - [Ultrasonic coagulation in the surgical treatment of retinal detachment].

PMID- 1014185
TI  - [Local interferon formation and prophylactic instillation of interferon
      inducers].

PMID- 1014186
TI  - [Experience with the use of interferon and its inducers in the treatment of
      trachoma].

PMID- 1014187
TI  - [Effectiveness of penicillin phonophoresis in purulent ulcers of the cornea
      (experimental study)].

PMID- 1014188
TI  - [Differences in the eye sensitivity to cycloplegic and mydriatic action of
      benactyzine].

PMID- 1014189
TI  - [H3-estradiol incorporation in the eyes of sexually immature, mature,
      ovariectomized, and adrenalectomized mice].

PMID- 1014190
TI  - [Study of oxyproline excretion in patients with endogenous uveitis].

PMID- 1014191
TI  - [Age-specific changes in ultrastructure of the iris].

PMID- 1014192
TI  - [Complex diagnostic examination of patients with injuries of the orbit].

PMID- 1014193
TI  - [Orbital hemodynamics in unilateral exophthalmos].

PMID- 1014194
TI  - [Roentgen photophenomenon as a prognostic method in study of retinal function in
      patients with sequelae of corneal diseases].

PMID- 1014195
TI  - [Results achieved by ambulatory treatment of glaucomatous patients].

PMID- 1014196
TI  - [Stereo arteriography of ophthalmic artery].

PMID- 1014197
TI  - [Study of accommodation spasm in persons with combined myopia and accomodation
      spasm].

PMID- 1014198
TI  - [Condition of remote and stereoscopic vision in high myopia].

PMID- 1014199
TI  - [Results of an ophthalmological examination of children with cephalgia syndrome].

PMID- 1014200
TI  - [Immediate results following surgical treatment of accommodation strabismus].

PMID- 1014201
TI  - [Supression of hypophysial function and treatment of proliferating diabetic
      retinopathy].

PMID- 1014202
TI  - [Adrenal cortex hormones in ophthalmology].

PMID- 1014203
TI  - [Bourneville-Pringle syndrome].

PMID- 1014204
TI  - [New aspects in the biological preparation of tissues for plastic repair using
      V.P. Filatov's pedicle flap].
AB  - In the paper, the author's experience and literature data on studies of the role
      of biological processes developing in the host wound and grafted tissues in
      formation of the pedicled graft are reported. Considering these processes in the
      modern aspect in due account of general state of the organism, the status of
      local tissues, causes conditioning the defects formation and other factors, the
      author suggests new grounds for his concepts concerning the rational of active
      biological preparation of tissues in creating the pedicled graft. The technic of
      the preparation in question and results of its successful utilization in 25
      patients are described, the conditions for wound and tissue healing being
      unfavourable due to different reasons, and in case of need of large quantities of
      plastic material the former also may be used.

PMID- 1014205
TI  - [Reconstruction of the orbital floor using a nasal septum flap after resection of
      the maxilla].

PMID- 1014206
TI  - [Mesenchymal teratoma of the anterior mediastinum].

PMID- 1014207
TI  - [Invagination of the vermiform appendix into the cecum].

PMID- 1014208
TI  - [Aorto-intestinal fistula after aortofemoral prosthesis].

PMID- 1014209
TI  - [Abscess of the spleen].

PMID- 1014210
TI  - [Femorofemoral cross shunting in thrombosis of an aortofemoral prosthesis].

PMID- 1014211
TI  - [Diagnosis and treatment of renal artery aneurysm].

PMID- 1014212
TI  - [Differential diagnosis of peripheral lung cancer and hamartoma].
AB  - Under study were clinico-roentgenological data on 102 patients with peripheral
      lung cancer, which were compared with analogous materials of 54 hamartoma
      observations. The observations indicated, that it is nearly always feasible to
      recognize peripheral cancer of the lung and hamartoma based on the anamnesis and
      clinico-roentgenological findings. A valuable adjunct in establishing the
      diagnosis of spheroid lung cancer is a roetgenological "flame sympton" i.e.
      indistrinct radiating peripheral (lateral) portion of the cancer node contour,
      observed by the authors.

PMID- 1014213
TI  - [Resection of the lung in tuberculosis].
AB  - The results of surgical treatment in 175 patients (two patients were subjected to
      bilateral pulmonary resection) are reported. Fibrous-cavernous tuberculosis was
      observed in 92 patients. The complex of preoperative management comprised
      increased doses of ascorbic acid to prevent postoperative capillary hemorrhages.
      Postoperative complications developed in 23 patients, these were liquidated in 20
      cases. There were 3 deaths. A complete cure was gained in 99 patients,
      considerable improvement--in 71, some improvement--in 2. Late results were
      followed up in 160 patients within the period from 1 to 4 years. The recurrent
      tuberculous process was noted in 6 cases.

PMID- 1014214
TI  - [New method of treating the postresection wound surface of the liver, spleen and
      pancreas].
AB  - Experimentally on dogs the authors have elaborated a new method of treatment of
      postresection wound surface of the liver, spleen and pancreas by using a heated
      head of an electrothermocoagulator with subsequent sealing with BF-glue. The
      application of the method concerned allow secure hermetization of the wound
      surface. Thi method is insignificantly traumatic and is followed by no
      complications. Tissue responses to thermocoagulation and BF-glue anr not markedly
      pronounced. The method suggested by the authors seems to be advantageous for the
      clinical practice.

PMID- 1014215
TI  - [Activity of the reparative processes in the liver in cholelithiasis].
AB  - The authors have studied the character and rate of reparative reactions in liver
      biopsy specimens from 207 patients suffering cholelithiasis. The activity of
      reparative processes in hepatic parenchyma is evidenced by an increased amount of
      binuclear and polyploid hepatocytes, the appearance of mitosis figures. It is
      evident that active reparative processes underlie the compensatory function of
      the liver in cholelithiasis.

PMID- 1014216
TI  - [Functional and morphological state of the liver in secondary cholangitis].
AB  - Studies on the liver state from the functional-morphological point of view in
      patients with acute and chronic secondary cholangitis have revealed in all cases
      the involvement of hepatic parenchyma with the development of cholangiohepatitis.
      In its acute course and timely performed operative interventions the process in
      the liver tends to subside. The authors consider that due to the absence of pure
      forms of cholangitis this term seems to be questionable, and they recommend to
      substitute it in all cases by the term cholangiohepatitis.

PMID- 1014217
TI  - [Late results of surgical treatment of mitral stenosis].
AB  - An analysis of late results of closed mitral commissurotomy in 408 patients with
      the follow-up period to 18 years is presented. As pinpointed further late results
      of mitral commissurotomy were found to depend on the degree of stenosis of left
      atrioventricular orifice and concomitant mitral insufficiency, on how radical the
      operation was, on the presence of gross morphological changes in the valve, the
      stage of the disease, the activity of rheumatic process, patients' age and terms
      of observation. The predisposing factors and causes of restenosis of left
      atrioventricular valve are characterized.

PMID- 1014218
TI  - [Histochemical study of the enzymes of the denervated liver].
AB  - The author has studied histochemically the localization and level of enzymic
      activity of different metabolic cycles in the liver of dogs during the period
      from 1 week to 1 year after its mixed denervation. The activity of nearly all
      enzymes under study was found to be increased 1--2 weeks following denervation
      and to be decreased up to the control level after 1 month with subsequent
      normalization later. The study of protein-formation function revealed its
      complete normalization 3 months following the operation. The results of these
      studies made it possible to conclude that denervation of internal organs is not
      associated with marked and continuous impairment of metabolic processes, and it
      should not be an obstacle for their transplantation.

PMID- 1014219
TI  - [Cancer of th e exrahepatic bile ducts].
AB  - The authors have summarized their experience with observations and treatment of
      101 patients with cancer of extrahepatic bile ducts. Based on personal authors'
      findings it is concluded, that cancer of bile passages can frequently develop
      against the background of cholelithiasis. Taking into account little efficacy of
      surgical therapy, the prophylaxis of cancer development, namely an early
      operation for cholelithiasis, is believed by the authors to be the most effective
      measure.

PMID- 1014220
TI  - [Cholecystectomy from a median incision and the lack of need for gauze tampons].
AB  - An analysis of surgical treatment in 482 patients with gallbladder affections is
      presented and estimated comparatively. Modern anesthesia with the use of
      myorelaxants allowed a neglect of most abdominal wall incisions and the
      performance of cholecystectomy from the upper median incision irrespective of
      patients's constitution and weight, moreover gauze tampons are not employed in
      the clinic any longer. Instead of them a rubber tube is introduced in the Winslow
      foramen through a trochar made puncture in the right subcostal space. Such
      measures enabled us to reduce considerably the number of various complications
      and the mortality in acute cholecystitis from 15.5% to 3.5%, to shorten the
      patient's stay at the hospital from 38 to 15 days, while in cholelithiasis--from
      30 to 13 days.

PMID- 1014221
TI  - [Some aspects of the complex treatment of acute suppurative perionitis].
AB  - The authors present an analysis of the results of complex treatment in 4318
      patients operated upon for acute peritonitis, caused by acute appendicitis,
      perforating gastric and duodenal ulcers, acute cholecystitis, ruptures and
      perforations of the intestine and other surgical and gynecological diseases.
      Patients with diffuse purulent peritonitis showed marked disorders in protein
      aminoacid, nitrogen, and water electrolyte metabolism, acid-base balance, a
      reduced nonspecific immune responsiveness of the organism. Therpeutic tactics was
      delineated taking into account the revealed changes.

PMID- 1014222
TI  - [Secretory activity of the small intestine after resection of the pancreas].
AB  - The experiments on dogs have shown that during 3-5 weeks after resection of 1/3
      and 2/3 of the pancreas the total amount of the excreted intestinal juice and the
      content of proper enteric enzymes in it (enterokinase, alkaline phosphatase and
      saccharase) are decreased. According to the author's data the activity of
      intestinal juice amylase and lipase being enzymes mostly of the pancreatic
      origin, transferred in the small intestine from blood, is enhanced due to
      impairment of the histo-hematic barrier in the region of the resected pancreatic
      stump. 2-3 months following resection of 2/3 of the pancreatic gland the amount
      of excreted intestinal juice was nearly unchanged, but the content of proper
      enteric enzymes was somewhat increased, as compared with background indices.

PMID- 1014223
TI  - [Objective control in treating arthrosis deformans of the knee joint in hospitals
      and under ambulatory conditions].
AB  - The aim of the present work is to study the peculiarities of upright position and
      walking in patients with deforming arthrosis of the knee joint and to make a
      conclusion as to the possibility of using biomechanical methods for an objective
      estimate of the efficacy of treatment in such patients. The authors examined 88
      patients with deforming arthrosis of various degree of severity and marked pain
      syndrome. In the examination separate weighing, seismoactography, ichnography and
      podography were employed. Deforming arthrosis of the knee joint was found to be
      accompanied with significant disorders in the upright position and walking,
      including a decreased static stress on the affected extremity, an increased
      amplitude oscillations of the body center of gravity while standing on the
      affected extremity and others.

PMID- 1014224
TI  - [Operative treatment of hallux valgus].
AB  - A new method of operative treatment for hallux valgus consists in a derotational
      osteotomy of the first metatarsal bone and adductorotenotomy, that allows a
      correction of the deformity without an operation on the first metatarsophalangeal
      joint. A total of 67 patients were operated upon (81 operations). Late results
      were followed up in 48 patients (59 operations). Excellent and good results after
      the operation were noted in 47, satisfactory-in 10 and poor-in 2 observations.
      The operation is thought to be indicated in marked deformities.

PMID- 1014225
TI  - [Experience with treating complicated forms of abscessing pneumonia in children].
AB  - Under observation were 157 patients with different forms of abscessing
      pneumonias. Pleural complicaitons were noted in 113 patients (about 60%). The
      complex treatment was employed in all patients (intensive antibacterial therapy,
      immunotherapy, bacteriophage, administration of protein preparations, vitamin
      therapy, fresh blood transfusion, artery system and by means of percutaneous
      catheterization of th subclavian vein. The results of the treatment are
      described.

PMID- 1014226
TI  - [Methods for expanding the collapse lung in complicated abscessing pneumonia in
      children].
AB  - A comparative estimation of different methods of expanding the collapsed lung for
      staphylococcic pneumonia in children enabled the author to speak in favour of
      lung inflation by using an artificial occlusion of the bronchus with a peripheral
      fistula. This technic seems to be advantageous since a one-moment inclusion of
      the lung in the process of ventilation is found to contribute to prompt reduction
      oxygen deficiency of the organism, liquidation of the residual cavity and
      hemodynamic disturbances, and intoxication. The recovery of children is note din
      shorter terms. The time of patient's stay at the hospital is also shortened.

PMID- 1014227
TI  - [Errors in the differential diagnosis of acute appendicitis in children].
AB  - According to the authors' findings among 1027 children operated upon for
      appendicitis 61 children had diseases not related with inflammation of the
      appendicular process. Mesenterial lymphadenitis was observed intraoperatively in
      34 cases, pneumococcic peritonitis-in 15, invagination of the small and large
      intestine-in 3, diverticulitis of Meckel's diverticulum-in 3, ovarian apoplexy-in
      3, atonia of the urinary bladder-in 2. Diagnostic errors occurred as a result of
      improper analysis of the anamnesis data, rare incidence of the aforementioned
      diseases, and also due to the absence of reliable methods of objective laboratory
      and instrumental investigations of such patients.

PMID- 1014228
TI  - [Bilateral collapse of the lungs in a multiple fragmentation wound in a child].

PMID- 1014229
TI  - [Strangulation of Meckel's diverticulum in a diaphragmatic hernia in a child].

PMID- 1014230
TI  - [Giant trichobezoar of the stomach complicated by polyposis in a 15-year-old
      girl].

PMID- 1014231
TI  - [Acute destructive cholecystitis in a child].

PMID- 1014232
TI  - [Tissue tolerance to staphylococcal infection in multiple wounds of the soft
      tissues[].
AB  - The results of 254 experimental studies and 117 case reports of patients with
      multiple soft tissue injuries of different localization are analysed. Mutiple
      cutimuscular wounds were found to decrease the tolerance of injured tissues to
      purulent infection. Experimentally, on 130 rabbits the methods of rational
      prophylaxis of local purulent infection in case of multiple soft tissue wounds
      were studied. Their prophylactic effect in this pathology was 20% lower compared
      with single wounds of identical character.

PMID- 1014233
TI  - [Liver injury in opisthorchiasis].

PMID- 1014234
TI  - [Operative treatment of meniscus injuries to the knee joint].
AB  - The author suggests "A set of instruments for the performance of meniscectomy"
      which includes: a lift-probe, double-edged and end face meniscotome. The
      instruments provide for a search of the sites of meniscus injury and also its
      prompt atraumatic removal. A total of 220 operations were performed. Late results
      were studied in 104 patients. Excellent and good results made 90.4%, satisfactory
      9.6%, no poor issues were noted.

PMID- 1014235
TI  - [Spleen lesion in combined injury to the thoracic and abdominal organs].

PMID- 1014236
TI  - [Diagnostic and therapeutic importance of right-heart catheterization during
      operations on the lungs and in the early postoperative period in elderly
      patients].
AB  - Pressure in the right heart (CVP) was measured at different stages of lung
      resection and during the first postoperative days in 74 aged patients, operated
      upon for various pulmonary affections. Pneumonectomy was performed in 33
      patients, partial resection--in 31, thoracotomy--in 10. The pressure was measured
      by catheterization of the right heart, using the Valdman apparatus. No
      complications relative to catheterization of the right heart were noted.
      Intraoperative observations over CVP dynamics with due account of other
      hemodynamic indices, general patient's state and the operative stage provide for
      additional valuable data of the state of a patient operated upon. During the
      first days after pneumo- and lobectomy CVP was found to be decreased compared
      with initial values, that seems to be related with hypovolemia. Studies on the
      circulating blood volume and its components, carried out in 18 patients, have
      proved the presence of hypolvolemia in patients under consideration. These
      investigations make it possible to recommend continous catheterization of the
      right heart for early recognition of hemodynamic disturbances and a simultaneous
      use of the catheter for infusion of medical drugs.

PMID- 1014237
TI  - [Plaster arch support in treating fractures of the os calcis].

PMID- 1014238
TI  - [Hemodynamic indices and the volume of circulating blood in the surgical
      treatment of cancer of the esophagus and cardial portion of the stomach].
AB  - The authors report the data on changes in some indices of the hemodynamics, red
      blood, total blood serum protein, the circulatory volume and amount of the
      operative blood loss in radical surgical treatment of patients with cancer of the
      esophagus and cardia. Depending on the kind of anesthesia all patients were
      subdivided into three groups: in the first group ether-nitrous oxide-oxygen
      endotracheal narcosis was employed, in the second-fluothane-nitrous oxide-oxygen
      endotracheal narcosis and in the third-neuroleptanalgesia.

PMID- 1014239
TI  - [Esophagoscopy under anesthesia with diffusion breathing].
AB  - The authors have performed 180 esophagoscopies (in many cases repeatedly) under
      anesthesia in conditions of diffuse ventilation against the background of apnoe
      in patients with esophageal diseases, aged from 1 to 72 years. An analysis of ECG
      indicated no essential changes in the cardiac electric activity, that correlates
      well with the data of biochemical control, with the exception of persons with
      concomitant cardiac organic lesions in whom a decreased electric activity of the
      myocardium due to metabolic changes was noted.

PMID- 1014240
TI  - [Splenic rupture associated with gangrenous appendicitis in a child].

PMID- 1014241
TI  - [Peutz-Jeghers syndrome in an 11-year-old child].

PMID- 1014242
TI  - [Bilateral epiphyseolysis of distal epiphyses of the femur].

PMID- 1014243
TI  - [Use of neruoleptoanalgesia in the postoperative period].
AB  - The authors recommend a postoperative administration of the mixture consisting of
      phentanil, droperidol and dimedrol. The mixture would provide anesthesia during 4
      10 hours and a peaceful sleep during 2-4 hours. In case of necessity the mixture
      may be reinjected.

PMID- 1014244
TI  - [Case of malignant hyperthermia].

PMID- 1014245
TI  - [Selection of the methods of injusion therapy considering the complications
      related to catheterization of different veins].

PMID- 1014246
TI  - [Lactation mastitis].

PMID- 1014247
TI  - [X-ray laboratory in the dressing-operating area].

PMID- 1014248
TI  - [Disorders of blood circulation in acute pancreatitis].

PMID- 1014249
TI  - [Successful embolectomy from the inferior mesenteric and right femoral arteries].

PMID- 1014250
TI  - [Association of adenoma and cancer of the parathyroid glands].

PMID- 1014251
TI  - [Cavernous hemangioma of the liver].

PMID- 1014252
TI  - [Duodenectomy for duodenal stenosis caused by cancer of the major duodenal
      papilla].

PMID- 1014253
TI  - [Recurrent intussusception of the Meckel's diverticulum].

PMID- 1014254
TI  - [Strangulation of the uterus in recurrent inguinal hernia].

PMID- 1014255
TI  - [Prevention of displacement of bone nails during traction].

PMID- 1014256
TI  - [Adamantinoma of the long tubular bones].

PMID- 1014257
TI  - [Suppurative-necrotic pancreatitis and its surgical treatment].
AB  - Purulent-necrotic processes in the pancreas may arise against the background of
      different forms of acute pancreatitis. Biological tamponade of the pancreas with
      the greater omentum and hermical closure of the abdomen result in a reduced
      number of cases of the gland suppuration. The treatment of purulent pancreatitis
      should be complex, comprising an early surgical intervention with subsequent
      rational conservative therapy.

PMID- 1014258
TI  - [2-stage operations in cancer of the pancreatic head and major duodenal papilla].
AB  - As the first moment of the operation laparoscopic cholecystostomy was employed in
      63 patients. In 6 patients due to their grave condition no other operative
      interventions were performed. In 35 patients during the second operation various
      biliodigestive anastomoses were constructed. In 3 patients transduodenal
      papillectomy with lymphodenectomy was performed. Pancreatoduodenal resection was
      employed in 19 cases, three patients died postoperatively. The author's personal
      modification of pancreatoduodenal resection was used.

PMID- 1014259
TI  - [Compensatory reactions after surgical treatment of peptic ulcer].
AB  - The work is based on studies conducted in 30 experimental dogs with
      gastrointestinal ulcer induced experimentally, which were subjected to selective
      vagotomy with pyloroplasty after the Heinike--Mikulicz technic, and also in 22
      patients having gastric ulcerous disease who were subjected to trunk or selective
      vagotomy with drainage operations or vagotomy associated with economic gastric
      resection. As a result of investigation performed, it was found that the
      operative intervention on the stomach i. e. selective vagotomy with economic
      gastric resection both experimentally and clinically is accompanied with marked
      disturbances in the compensatory and adaptation mechanism in the organism, these
      are manifested in inhibition of oxido-reduction processes (a pronounced decrease
      in reduced glutathione level, an increase of oxidated glutathione, a great fall
      in blood vacant oxygen). The postoperative period is characterized by
      normalization of oxido-reduction processes, their normalization being but slow.

PMID- 1014260
TI  - [Surgical tactics in peptic ulcer devleoped after gastrectomy].
AB  - The authors analyse the materials pertaining to 96 patients with peptic ulcers
      arising after gastric resection. Eighty seven of them were subjected to 94
      surgical interventions. Attention is called to different causes of the ulcer
      occurrence and possibilities of their recognition. Depending on the cause of
      ulcer various operations were undertaken i.e. reresection of the stomach,
      vagotomy, removal of the remained protion of antral duodenal mucosa, total
      resection of the gastric stump. Indications to each kind of surgery under
      consideration are discussed.

PMID- 1014261
TI  - [Various problems of diagnosis and treatment of hyperparathyroidism].
AB  - Under observation were 30 patients with the clinical picture of
      hyperprarthyroidism. Resection of parathyroid adenoma was performed in 10 cases.
      Recovery was noted in 5 cases, in 5--the operation failed to yield any remarkable
      effect.

PMID- 1014262
TI  - [Possibility of leaving gastrin-producing pyloric glands in the stump of resected
      stomach].
AB  - Based on the data obtained in fibrogastrochromoscopy and histological studies of
      gastric biopsy specimens from patients with ulcerous gastroduodenal disease,
      prior to surgical intervention and after gastric resection for this affection, it
      was found that in "standard" gastric resection with 2/3 of the organ the
      possibility of remaining a portion of the antral mucous membrane in the gastric
      stump is practically excluded and, consequently, the role of this factor in the
      development of peptic ulcer of the anastomosis seems to unliely after the so
      called inadquate in extent gastric resections.

PMID- 1014263
TI  - [Removal of colonic polyps during colonofibroscopy].

PMID- 1014264
TI  - [Analysis of complications of synchronous combined excision of rectal cancer].
AB  - Based on the data of 185 patients the immediate results of surgical treatment for
      rectal cancer are discussed. The total number of intraoperative complications was
      6.5%. Postoperatively, complications were noted in 65.2%. The authors consider
      the dependence of complications on such factors as sex, age, patients' obesity,
      stage of the process and the kind of surgical intervention.

PMID- 1014265
TI  - Definition of the term "relaparotomy".

PMID- 1014266
TI  - [Methods of surgical approach to the adrenal glands].

PMID- 1014267
TI  - [Thoracophrenotomy as an approach to the adrenal glands].
AB  - For 88 operations in 69 patients with different adrenal diseases the author has
      employed transpleural (in 53 cases) thoracophrenotomy and subpleural (in 35
      cases) thoracophrenotomy along the tenth intercostal space. These approaches are
      recommended evenin one-moment bilateral operation (3 observations). The incidence
      of complications directly relative to the selected approach is less than in
      lumbotomy.

PMID- 1014268
TI  - [Characteristics of surgical treatment of the renal form of primary
      hyperparathyroidism].
AB  - Based on the experience of surgical treatment in 124 patients with renal form of
      primary hyperparathyroidism, the author gives a description of peculiarities of
      parathyroidectomy technic. Positive results  of the treatment were obtained in 32
      of 35 patients with spontaneous discharge of concretions. In bilateral
      nephrolithiasis postoperative recurrences, solitary stones the effect of the
      treatment depends both on renal surgery and therapy of pyelonephritis,
      nevertheless postoperative recurrences in these patients were 2.5 times as rare
      as in routine therapy.

PMID- 1014269
TI  - [Surgical treatment of microbladder of tuberculous etiology].
AB  - In tuberculous microcysts two technics of plastic surgery are suggested depending
      on the state of the prostatic gland and urethra. In patients with microcysts
      without specific lesions of the prostatic gland and urethra vertical
      sigmocystoplasty was performed after subtotal resection of the urinary bladder.
      In microcysts associated with tuberculosis of the prostatic gland or urethra
      perineal sigmocystoplasty after the authors' technic was employed.

PMID- 1014270
TI  - [Disorders of microcirculation and systemic circulation in acute pancreatitis and
      methods of their correction].
AB  - Clinically (in 186 patients) and experimentally the authors studied the
      peculiarities of variation in microcirculation, organ blood flow and systemic
      circulation in acute pancreatitis. The authors emphasize the leading role of
      early arising circulatory disorders in the pathogenesis of acute pancreatitis.
      The main pathways for correction of hemodynamic disturbances with due account of
      their causes, character and the sequence of development are described.

PMID- 1014271
TI  - [Our method of surgical treatment of compression fractures of tibial condyles].

PMID- 1014272
TI  - [Traumatic aneurysm of the superior gluteal artery].

PMID- 1014273
TI  - [Homotendinoplasty in severe hand injuries].

PMID- 1014274
TI  - [Secondary abscessing pneumonia in children].
AB  - Among 370 patients with staphylococcic abscessing pneumonia in 55 secondary
      pulmonary involvement (14.8%) was noted. Acute hematogenic osteomyelitis was the
      most frequent cause of sepsis. The treatment of patients with secondary
      staphylociccic abscessing pneumonia is described. The mortality was 40 per cent.

PMID- 1014275
TI  - [Choice of anesthesia in operations on the spine and spinal cord].
AB  - It was found that in patients with spinal and cerebrospinal lesions considerable
      circulatory disorders occur that are depended on the character of the disease and
      related homeostasis disturbances. As evidenced by the authors' findings the main
      causes of circulatory disturbances may be as follows: altered innervation below
      the focus of cerebrospinal lesion, the development of insufficiency of the
      myocardiac contractility, a changed general vascular resistance, a decrease of
      total circulatory volume.

PMID- 1014276
TI  - [Adrenal cortex function after local, peridural and potentiated peridural
      anesthesia].
AB  - The study of the adrenal function in local anesthesia and one-moment peridural
      anesthesia in operations for analogous affections--venous varicosity of the lower
      limbs, indicated no differences in changes of the adrenal cortex functioning. In
      one-moment peridural anesthesia, potentiated with neurolentanalgesics a tendency
      was observed to an increased glucocorticoid function of the adrenal gland, which
      should be ascribed to the effect of neuroleptanalgesics.

PMID- 1014277
TI  - [Method of correction of microstomia and deviation of the mouth angles by
      rotation of trapeziform and triangular flaps of the mouth mucosa].
AB  - In the paper, the author suggests an essentially new method of dilation of the
      oral orifice and elimination of mouth angles deviations basing on the principle
      of new redistribution of local tissues by means of rotation of a trapeziform
      graft of the mucosa with its submucous layer from the buccal and adoral region.
      In this method one uses more adequate tissues, which reserves in case of
      microstomia are located in the buccal and adoral region. The successful
      utilization in 60 patients of the suggested method of elimination of microstomia
      arising due to different causes enabled the author to recommend it widely for
      reparative surgery.

PMID- 1014278
TI  - [Method of drainage of the common bile duct with the aid of a tube formed from
      the omentum].
AB  - The author suggests a tube formed from the omentum and enveloping a drainage
      rubber tube like a muff. When fixed to the common bile duct and parietal
      peritoneum, it allowed him to eliminate the drawbacks of currently used
      drainages.

PMID- 1014279
TI  - [Method of venectomy with intravenous transillumination].
AB  - A probe suggested by the author (a modification of Babcock probe) makes it
      possible to perform venectomy under the optic control, that prevents errors
      relative to determination of the site of a probe olive and collaterals and
      provides for a better cosmetic effect of the operation.

PMID- 1014280
TI  - [Diagnosis and treatment of visceral form of hyperparathyroidism].
AB  - Under observation were 131 patients with primary hyperparathyroidism, 22 of them
      (16.8%) suffering its visceral form. Seventeen patients aged from 31 to 60 years.
      The duration of the disease from the onset of initial signs till establishment of
      the final diagnosis was from 3 to 21 years. In two-thirds of patients this period
      lasted from 4 to 7 years. The clinical picture of the disease is described. All
      patients were subjected to surgical therapy--adenomas were removed in 18
      patients, hyperplastic bodies --in 3, parathyroid cancer--in 1. No lethal issues
      were observed. The follow-up terms were from 1 to 7 years.

PMID- 1014281
TI  - [Clinical characteristics of intestinal esophagoplasty in cicatricial stenosis of
      the esophagus].
AB  - In 136 patients with cicatrical strictures of the esophagus the author performed
      total esophagoplasty, using the left colon (89 cases), the right colon with
      terminal iliac portion (8 cases), the small intestine by Roux-Herzen-Judin
      technic (27 cases) and the small intestine with primary reconstruction of the
      graft (12 cases). The results obtained and also early and late complications of
      the methods of esophagoplasty employed are clinically analysed. Based on clinical
      examinations of the patients within the terms from 1 to 16 years, the data of
      roentgenokinematography and the degree of their rehabilitation, the function of a
      newly constructed esophagus is estimated.

PMID- 1014282
TI  - [Main clinical syndromes after gastrectomy for cancer].
AB  - The immediate and late results of 219 gastrectomies performed for cancer were
      analysed. The postoperative mortality was 13.2%, the survival over 5 years--23.7%
      to the number of operated patients, and 34.7% to the number of those followed up.
      A functional estimation of the sequelae of 169 gastrectomies, performed by
      different technics, enabled the authors to reveal pathological changes on the
      part of the liver, gallbladder, esophagus, pancreas and intestine. The clinical
      picture of some major pathological syndromes after gastrectomy for cancer of the
      stomach are described. A certain dependence between the type of surgical
      intervention and the character of postgastrectomy disorders was noted.

PMID- 1014283
TI  - [Causes of mechanical afferent loop syndrome after stomach resection in peptic
      ulcer].
AB  - The author observed 27 patients with the adducent loop mechanic syndrome (ALMS),
      which was caused by scarring deformations, ulcerous and cancer process in the
      region of anastomosis, constructed after one of Billroth-2 technics, impairing
      evacuation of the adducent loop content. The diagnosis was established on the
      basis of clinical findings and pinpointed further by roentgenoscopy and
      fibrogastroscopy. The presence of helminthic invasion of the liver-
      opisthordiasis resulted in hepatitis, pancreatitis that would not respond to
      therapy in patients with ALMS. Conservative measures in this syndrome yield but
      only a provisional effect. Eighteen patients were operated upon.

PMID- 1014284
TI  - [Treatment of gastrointestinal polyps].
AB  - The brief historical information concerning the stages in endoscopic polypectomy
      development is given. Indications and contraindications to polypectomy by means
      of modern fiberendoscopes are formulated. The results of 409 polypectomies
      accomplished by means of endoscopes are analysed. The method of electroexcision
      of polyps is described, and it is to be emphasized that the former is the most
      radical one among the currently used technics of polypectomy. Attention is paid
      not only to great therapeutic efficacy of the operation but also to its economic
      effectiveness.

PMID- 1014285
TI  - [Enzymological studies in biliary tract diseases].
AB  - The authors have studied the activity of enzymes of pentosophosphate pathway in
      patients with different diseases of bile outflow tracts. An increased activity of
      the enzymes under consideration was found after an operation for acute
      phlegmonous, acute gangrenous and chronic cholecystitis, chronic
      cholecystopancreatitis, mechanic jaundice. It is the authors' opinion that the
      changes revealed are not specific, and they can not be considered a diagnostic
      test in bile passages diseases, however, these tests may serve as the control of
      the efficacy of therapy and functional state of the liver.

PMID- 1014286
TI  - [Types of congenital dilatation of the common bile duct].

PMID- 1014287
TI  - [Composition of biliary calculi and possible causes of their formation].
AB  - The ingredients and chemical content of 135 biliary calculi from 120 operated
      patients was studied roentgenostructurally, with infra-red spectrophotometry and
      visually. Based on the results obtained, it proved feasible to differentiate 4
      groups of calculi differing in their content: cholesterol, metallocholesterol,
      cholesterolphosphatide, phosphatide-protein.

PMID- 1014288
TI  - [Capillary blood flow and oxygen consumption in the leg muscles in obliterating
      endarteritis].
AB  - Free oxygen tension (pO2) and tissue blood flow (by the rate of elimination of
      hydrogen from the tissues after its single inhale) at rest and after functional
      stresses (oxygen inhalation, walking) were studied polarographically in healthy
      persons (10), patients with obliterating endarteritis (25) and obliterating
      atherosclerosis (22). It was shown that the rate of pO2 and capillary blood flow
      reduction in the tissues and peculiarities of their changes in response to
      functional stresses aid in establishing the precise differential diagnosis of
      obliterating endarteritis and atherosclerosis, a stage of the disease and also in
      evaluating the efficacy of treatment.

PMID- 1014289
TI  - [Treatment of nonspecific lymphadenitis in children].
AB  - Since 1970 to 1974 one hundred and eighty eight children with lymphadentis of
      different localization were observed by the authors. In 12 of 188 patients the
      diagnosis of chronic lymphadenitis was established, in the remainder of acute
      one. Seventy two patients (38.1%) needed surgical therapy, 106 patients were
      treated conservatively. Some practical recommendations are given.

PMID- 1014290
TI  - [Irrigation of the bone marrow canal in the treatment of acute hematogenic
      osteomyelitis in children].
AB  - The method of treatment of acute hematogenic osteomyelitis of long tubular bones
      in children is described. This method was employed in 31 children, aged from 3 to
      14 years, with acute hematogenic osteomyelitis. The complete recovery was noted
      in 27 cases, in 4--due to late hospitalization and secondary infection the
      inflammatory process became chronic.

PMID- 1014291
TI  - [Early diagnosis of acute hematogenic osteomyelitis in children].
AB  - As evidenced by the author's findings, the use of the method of ultrasonic
      echolocation of long tubular bones facilitates the recognition of acute
      osteomyelitis in the stage of intramedullary abscess and also makes it possible
      to reduce the number of diagnostic errors and improve the results of treatment.

PMID- 1014292
TI  - [Diagnosis and treatment of acute purulent pleurisy in children].
AB  - Under consideration is the diagnosis and treatment of different forms of
      staphylococcic destruction of the lung in children. The immediate and late
      results of treatment are studied. Application of the intensive therapy in
      association with different surgical interventions enabled the authors to obtain
      good immediate and late results in children with staphylococcic destruction of
      the lung.

PMID- 1014293
TI  - [Course of the postoperative period in infants with suppurative lung diseases].
AB  - An analysis of postoperative complications in 167 infants, operated for
      suppurative lung diseases, indicated that these complications are mainly the
      result of the purulent-inflammatory process progression. Recommendations
      concerning the prophylaxis against these complications with the analysis of the
      results of their use are given.

PMID- 1014294
TI  - [Possibility of early operations in severe traumatic shock under the protection
      of assisted circulation].
AB  - The results of treatment in 28 patients with extremely severe multiple injuries
      are analysed: 21 of them had open, comminuted, crushed fractures or tearing of 44
      extremities. After a failure of antishock measures an assist extracorporeal
      circulation with oxygenation was instituted, and surgery was performed. In 128
      experiments on dogs a explosive bullet wound was inflicted on the knee joint: a
      comminuted intraarticular fracture of 2-3 bones was produced, followed by 25-30%
      bloodletting and additional trauma of the damage site. In 23 control experiments
      without using the heart-lung machine but with routine antishock measures 83% of
      animals died after the amputation and 17%--survived. A conclusion is made on the
      rationale and efficacy of an assist extracorporeal circulation in severe
      traumatic shock, that would make is possible to perform an early operation and to
      eliminate "the trigger mechanism" of shock.

PMID- 1014295
TI  - [Change in serotonin content in burns].
AB  - Serotonin in blood, in burnt skin and burn blister fluid was studied
      fluorimetrically in 90 patients during different periods of burn disease. Burn
      disease was found to be accompanied with a considerable reduction of serotonin
      level in patients' blood, its increased content in burnt skin and its appearance
      in the blisters fluid. There is a direct correlation between the burn gravity and
      the rate of serotonin level reduction in blood. The data obtained allow a
      suggestion that a decreased serotonin content in blood is related with its
      accumulation in burnt skin and appearance in the blister fluid.

PMID- 1014296
TI  - [Damping method of traction].
AB  - Damping of the system of skeletal extension with steel coil springs, ball bearing
      blocks and capron fishing-line was shown by the authors to be a necessity, since
      the routinely used "rigid" systems proved to be less effective. The authors have
      elaborated a new method of elimination of angular deviations of fragments and
      dislocations in width.

PMID- 1014297
TI  - [Postural crush syndrome].
AB  - The clinic of such injuries is characterized by marked local manifestations
      (solid progressive edema of the injured limb leading frequently to decompensated
      ischemia) and a high incidence of acute renal insufficiency. Hemostatic disorders
      are manifested in hyperkalemia, hyponatremia, hypocalcemia, cell-extracell
      transfer of electrolytes, metabolic disorders in the myocardium, as evidenced by
      EEG findings. It is the authors' opinion that therapeutic measures should be
      aimed at liquidation of the progressive edema (hypothermia, fasciotomy),
      prevention of acute renal insufficiency and correction of metabolic disorders.

PMID- 1014298
TI  - [Diagnosis and treatment of post-traumatic chronic venous insufficiency of the
      lower limbs].
AB  - The authors report 87 observations on posttraumatic chronic lymphovenous
      insufficiency of the lower extremities. Basic methods of examination of such
      patients; rheovasography, polarography, thermography, veno- and lymphography are
      described. Grounds are given for the complex treatment of chronic lymphovenous
      insufficiency after A.V. Vishnevsky and A.A. Vishnevsky technic and the procedure
      of fibrolysis with supra- and subfascial ligation of communicating veins.

PMID- 1014299
TI  - Oestrogen receptors in feline mammary carcinomas.
AB  - Twenty primary or metastatic felline mammary tumours were assayed for the
      presence of oestrogen receptors by the dextran-coated charcoal method. In only
      two of the tumours was the presence of specific oestrogen binding protein
      demonstrable. The high negative rate in comparison with human and canine mammary
      tumours assayed under similar conditions seemed to be a peculiar feature of the
      feline tumours and suggested a lack of oestrogen dependency. The possibility
      remains that other hormones may be concerned with the growth of feline mammary
      tumours and further work is in progress.

PMID- 1014300
TI  - Isolation and segregation of non-haemadsorbing strains of African swine fever
      virus.

PMID- 1014301
TI  - Eperythrozoon wenyoni anaemia in cattle.

PMID- 1014302
TI  - Klebsiella aerogenes in mares.

PMID- 1014303
TI  - Veterinary surgeons and the Medicines (Labelling) Regulations 1976.

PMID- 1014304
TI  - Non-surgical correction of a uterine torsion in the mare.
AB  - A case of uterine torsion is described and its correction under general
      anaesthesia by a method described by Schaffer for the cow. The degree of torsion
      was 180 degrees and in a clockwise direction. After correction the foal was found
      to be alive and in anterior presentation and ventral position; it was born
      normally 84 days later.

PMID- 1014305
TI  - Bovine hypocuprosis.

PMID- 1014306
TI  - Diagnosis of swine dysentery: spirochaetes which may be confused with Treponema
      hyodysenteriae.
AB  - Spirochaetes, designated PWS, microscopically resembling Treponema
      hyodysenteriae, were isolated from the colon contents of pigs with post-weaning
      scours from three herds, which on clinical and epidemiological grounds were
      thought to be free from swine dysentery. One of the isolates was fed to pigs
      experimentally but no evidence of disease was noted. Their cultural
      characteristics differed from those of T hyodysenteriae but they were similar to
      those of a non-pathogenic spirachaete (4/71) which had been isolated previously
      from the laboratory's dysentery-free herd. Smears prepared from cultures of the
      PWS spirochaete, 4/71 and two virulent and one avirulent strain of T
      hyodysenteriae were all positive to a fluorescent antibody test which was in use
      as an aid to the diagnosis of swine dysentery in the United Kingdom.

PMID- 1014307
TI  - Bacteria associated with beak necrosis in broiler breeder hens.
AB  - Beak necrosis occurred in 48 per cent of female broiler breeders used fro
      nutritional studies but none was found in male broiler breeders or in either sex
      of single comb white Leghorns. About 10 per cent mortality, probably largely due
      to beak necroses, occurred in the affected flock. Based on electron microscopic
      photographs of affected beak tissue, we suggest that in our study the breakdown
      of beaks was associated with the presence of a single morphological type of Gram
      positive bacterium.

PMID- 1014308
TI  - The feeding of zinc bacitracin to growing rabbits.

PMID- 1014309
TI  - A case of diesel oil poisoning in a ewe.

PMID- 1014310
TI  - Arizona in turkeys.

PMID- 1014311
TI  - Bovine abortion.

PMID- 1014312
TI  - Skin lesions in guinea-pigs.

PMID- 1014313
TI  - [Clinico-x-ray manifestations of Hodgkin's disease of the gastrointestinal
      tract].

PMID- 1014314
TI  - [X-ray endoscopic correlations in ulcerative lesions of the stomach in persons of
      advanced and old age].

PMID- 1014315
TI  - [Physico-chemical properties and means of preparing suspensions of barium
      sulfate].

PMID- 1014316
TI  - [X-ray cinematography and its place in the arsenal of current methods of x-ray
      studies].

PMID- 1014317
TI  - [Use of large frame fluorography for detecting esophageal cancer during mass
      screening].

PMID- 1014318
TI  - [Late results following direct anastomosis surgery for esophageal stresia].

PMID- 1014319
TI  - [X-ray diagnosis of peptic ulcer of the small intestinal insertion].

PMID- 1014320
TI  - [X-ray examination in the diagnosis of the dumping syndrome].

PMID- 1014321
TI  - [Bauhin's valve in normal subjects and in several pathologic states].

PMID- 1014322
TI  - [Parietography following surgery of the large intestine].

PMID- 1014323
TI  - [X-ray features of the bile ducts in patients with non-functioning gall
      bladders].

PMID- 1014324
TI  - [Standardizing the work of x-ray room personnnel].

PMID- 1014325
TI  - [Organization of the x-ray-fluorographic service in a regional polyclinic].

PMID- 1014326
TI  - [Improving the quality of radiology teaching in medical schools].

PMID- 1014327
TI  - [Pneumogastrographic semeiotics of stomach diseases].

PMID- 1014328
TI  - [Case of capillary angioma of the stomach].

PMID- 1014329
TI  - [Diagnosis of primary multiple synchronous cancer of the stomach].

PMID- 1014330
TI  - [Case of polyp of the duodenal bulb].

PMID- 1014331
TI  - [Two cases of villous tumors of the duodenum in patients with diffuse polyposis
      of the large intestine].

PMID- 1014332
TI  - [Case of lipoma of the large intestine].

PMID- 1014333
TI  - [Differential diagnosis of tuberculosis with cancer metastases to the lung].

PMID- 1014334
TI  - [Case of familial mucoviscidosis].

PMID- 1014336
TI  - [Ways to improve the quality of training of veterinary physicians].

PMID- 1014335
TI  - [Case of a large foreign body of the right lower lobe bronchus].

PMID- 1014337
TI  - [Teacher and student].

PMID- 1014338
TI  - [Work education of students].

PMID- 1014339
TI  - [Let us improve the teaching of veterinary meat inspection].

PMID- 1014340
TI  - [Control of mastitis on commercial dairy complexes of the GDR].

PMID- 1014341
TI  - [Experience with calf maintanence].

PMID- 1014342
TI  - [Isolated rearing of young live stock].

PMID- 1014343
TI  - [Means and methods of controlling blood-sucking flies].

PMID- 1014344
TI  - [Oxamate, an effective repellent].

PMID- 1014345
TI  - [Study of immunity in foot-and-mouth disease using the complement-binding
      inhibition reaction].

PMID- 1014346
TI  - [Purification and concentration of the rabies virus on an aluminum phosphate
      gel].

PMID- 1014347
TI  - [Immunity indices in swine closely inbred].

PMID- 1014348
TI  - [Pathomorphology of the bursa of Fabricius in poultryi1].

PMID- 1014349
TI  - [Specific prophylaxis of foot-and-mouth disease].

PMID- 1014350
TI  - [Anthrax morbidity in the Ukrainian SSR].

PMID- 1014351
TI  - [Control of poultry ectoparasites].

PMID- 1014352
TI  - [Aerosol against psoroptic mange in rabbits].

PMID- 1014353
TI  - [Parasites of roach and pike-perch fry].

PMID- 1014354
TI  - [Effectiveness of antimastitis preparations].

PMID- 1014355
TI  - [Diagnosis of mastitis during the dry cow period and after calving].

PMID- 1014356
TI  - [From the practice of obstetrics, gynecology and artificial insemination].

PMID- 1014357
TI  - [Biological bases for the rehydration of calves with dyspepsia].

PMID- 1014358
TI  - [Analysis of the results of a study of morbidity].

PMID- 1014359
TI  - [Effect of sulfene on the body of sheep].

PMID- 1014360
TI  - [Treatment of acute phthalophos poisoning in animals].

PMID- 1014361
TI  - [Cumulative properties of dimidin].

PMID- 1014362
TI  - [Sperm-autophagocytosis in rams affectes with Brucella ovis].
AB  - Studied was micrographically the semen of rams affected with infectious
      epididymitis admixed with leukocytes and Brucella ovis organisms. The animals
      were CFT-positive for brucellosis. It was found that in addition to the
      abundantly phagocytized Brucellae in the cytoplasm of the polymorphonuclear
      leukocytes there were fairly often surrounding sporadic spermatozoa or groups of
      them whose flagellae and heads have penetrated into the respective leukocyte. To
      elucidate this phenomenon ultrasections were studied of leukocytes isolated from
      the semen of these animals using electron microscope. Autophagocytosis of the
      spermatozoa was observed, manifested to a varying degree. In some of the cases
      the spermatozoa showed no changes, while in other cases there was lysis
      predominantly of the plasmalemma; still in third cases both the leukocytes and
      the phagocytized elements (spermatozoa and Brucella organisms) were completely
      destroyed. It is believed on the basis of ultrastructural data that phagocytosis
      takes place actively through engaging the pseudopodia of the leukocytes in the
      epididmis where the spermatozoa are in the status of anabiosis. On the other
      hand, proceeding from the state in which there are phagocytized heads vs. fully
      retained normal structure the concept is set forth that probably spermatozoa gain
      access to the leukocytes by means of active penetration. The authors refer to
      this immunologic phenomenon in the biology of breeding, first observed by them,
      as autophagocytosis of spermatozoa.

PMID- 1014363
TI  - [X-ray picture of the limb osteo-articular apparatus of calves of the Sofia brown
      breed of cattle].
AB  - X-ray investigations were carried out on 10 three-month-old and 10 six-month-old
      calves (each group consisting of 5 male and 5 female animals) of the Sofia Brown
      cattle breed in order to obtain and study the normal roentgenologic picture of
      the bone-and-joint apparatus of the limbs. It was established that in this
      breed's calves the contours of the bones are clearly delineated and assume an
      angular configuration after the age of three months, which later on becomes more
      pronouncedly expressed. At the insertion points of the tendo-ligamentous
      apparatus there appear in the distal parts of the bones, in a volar and plantar
      aspect an uneveness, which is likewise more strongly manifested with the advance
      in age. The structural picture of substantia spongiosa in the metaepiphyseal,
      heel, shoulder, and elbow processes assume the so-called moderate spottiness, and
      in some parts in the case of six-month-old calves there is rough spottiness. The
      medullary canal becomes more clearly visible in six-month-old calves that it is
      in the three-month-old ones. The relief of the metaepiphyseal portions roughens
      in the older calves, is uneven and becomes more compact. With the advance in age
      the deeper layer in the joint cartilage is replaced by the growing subchondral
      bone lamina, this leads to the thinning of the cartilage and the diminishing of
      the roetgenologically visible joint fissure. Such phenomenon is observed in all
      joints up to the age of six months, and fluctuates in size within the range of
      1,5 to 3 mm. The only exception is the knee joint where, owing to the menisci the
      joint fisure is wider (about 5 mm). The joint fissures in six-month-old calves,
      in contrast to the three-month-old ones, are with better manifested contours.

PMID- 1014364
TI  - [Effect of several factors on the estrogen activity of lucerne].
AB  - Investigations were carried out on the estrogen activity of lucerne from various
      mowings harvested in years of different climate, studying the effect of age and
      yield of the crop. The observations were made during three successive years on
      local populations of lucerne grown under nonirrigation conditions. The estrogen
      activity was determined ny Bikov's biologic method, and the presence of cumestrol
      and genestein was established through chromatography. It was found that the
      estrogen activity of lucerne was to a large extent dependent on the intensity of
      growth. Young plants giving higher yield of green mass and dry matter manifested
      higher estrogen activity. Highest was the activity of lucerne from the first
      mowing, gradually decreasing in each of the following mowings. Variations were
      likewise established in the content of genestein and cumestrol in dependence on
      the mowing itself and the yield. All samples demonstrated that genestein was
      present in the first and fourth mowing, while the content of cumestrol varied
      within a wide range showing no markedly expressed correlations. The activity of
      the local lucerne populations during the first years of using the crop and the
      first mowings of green mass was shown to bring about disturbances in the
      reproduction process of ruminant animals provided lucerne is offered for a long
      time in greater amounts.

PMID- 1014365
TI  - [Effect of betaine hydrochloride on broiler chickens when used alone or in
      combination with vitamin B12].
AB  - The studies were carried out with 2287 broilers aged from 3 to 56 days, divided
      when one-day-old into four equal groups. The first group were fed the common
      ration and served as controls. The remaining three groups were experimental, the
      broilers of the second group being offered the basic common ration enriched with
      0.2 per cent betaine. The third group were also given the ordinary ration,
      however, they received in the drinking water some 10 mug vitamin BUI per one
      kilogram feed each. The fourth group received both betaine and vitamin B12 at the
      rates indicated. Results showed that betaine hydrochloride offered either alone
      or in combination with vitamin B12 contributes to increasing the liveweight gain
      of broilers in the course of the starter period, but its use in doses of 0.2 per
      cent in the finishing period is not effective.

PMID- 1014367
TI  - [Laboratory stock breeding and gnotobiotics].

PMID- 1014366
TI  - [Effect of phospholipase c on the lipid composition of the membranes of antigen
      stimulated macrophages].
AB  - Data are presented on the changes in the conformation of the membrane of antigen
      stimulated macrophages as a result of studying the changes in their phospholipid
      composition. It was found that antigen stimulation increases the amount of
      phospholipids in the membrane of the macrophagesas well as the susceptibility of
      these phospholipids of the normal (unstimulated) macrophages. This phenomenon of
      more easily setting in hydrolysis is discussed.

PMID- 1014368
TI  - [Pathomorphology of lung alterations in calves naturally infected with the virus
      of infectious rhinotracheitis].
AB  - In addition to diphtheroid rhinitis, and tracheitis, the infectious
      rhinotracheitis in calves has also been accompanied by a catarrhal-and-necrotic
      pneumonia. The mucous membrane of the bronchi, bronchioles, and alveoli in such
      cases is edematous with occasional necrotic areas. The necroses are focal and
      areactive. The peribronchial lymphoreticular system shows no signs of
      proliferation. The necrotic lesions in the bronchi and alveoli are considered as
      the porte d'entree of the bacterial infection that aggravates the course of the
      disease and fairly often leads to death.

PMID- 1014369
TI  - [Coliform microflora of commercial Caucasian cheese].
AB  - Studied was in the course of several years the extent of coliform bacterial
      contamination and the peculiarities the bacteria present in ripened cow's and
      ewe's white brine cheese offered for consumption. It was demonstrated that these
      kinds of cheese released in the commercial system contain up to 3.1 per cent
      coliform bacteria. Certain correlation was established between the coliform count
      in the cheese and the degree of ripening, the consistence, and the aspect of the
      cross section surface. If hygiene measures were not observed cheese could be
      contaminated additionally with coliforms during handling in the shops. Coliform
      microflora was presented mainly by strains characteristic of fresh fecal
      contamination (E. coli) and urease-positive organisms of the Citrobacter and
      Enterobacter genera. To guarantee the consumption of qualitative (in terms of
      hygiene) white brine cheese it is necessary to include into the respective
      standards the index "coli titer" of a unit value.

PMID- 1014370
TI  - [Comparative study of infectious and atypical encephalomyelitis in birds].
AB  - Studied were morphologically a total of 234 birds for infectious
      encephalomyelitis (IE) and atypic encephalomyelitis (AE) of which 70 were
      experimentally infected with standard reference strains of IE (Calnek 1143-42
      birds, and Van Roeckel 28 birds), 32 were infected with a brain suspension of
      affected with AE birds, and 110 were spontaneously affected with AE. Those of the
      birds that were infected with the standard strains of IE as well as with the
      brain suspension exhibited changes in the central nervous system in the form of a
      non-suppurative encephalomyelitis, and in the viscera--lymphoidcell
      proliferations. These alterations proved analogous with those observed in birds
      spontaneously affected with AE. The changes in CNS in the case of IE were
      localized in the brain and the spinal cord, while the lesions in the case of AE
      were found chiefly in the brain. In AE there were perivascular lymphoidcell were
      groupings along the peripheral nerves. It was concluded that the histologic
      changes established may well serve to differentiate IE from AE in Marek's
      disease, the transitional paralysis, the Newcastle disease, and the alimentary
      encephalomalacia.

PMID- 1014371
TI  - [Swine infected with atypical mycobacteria].
AB  - Pigs spontaneously affected with tuberculosis responded with well expressed signs
      to avian tuberculin, and weakly to bovine tuberculin. Mycobacterium avium
      cultures of serotype--2 were isolated from 76.9% of them, and  M. avium cultures
      of serotype -1-from 23.1% of them. The lymph nodes were enlarged, with granulated
      cross-section area of presenting multiple necroses, some of the latter being in a
      process of calcification, and some fully capsulated. Histologic changes were also
      observed characterized by peritrabecular oedemas, decrease in the lymph elements
      and proliferation consisting of reticular and epitheloid cells. Although rarely
      there were also tubercules with giant cells of Langerhans type. Pigs given orally
      Mycobacterium battey (intracellulare), M. fortuitum, M. aquae, M. vaccae, and M.
      smegmatis responded with an allergic reaction on the 30th day following
      infection. The skin reactions were better manifested with the use of avian
      tuberculin. The blood serum of such pigs contained CFT-positive antibodies that
      were specific for the Mycobacterium genus. The histopathologic changes in the
      lymph nodes were of proliferative and infiltrative character. Tubercules of giant
      cells and necroses with calcification were not established.

PMID- 1014372
TI  - [Characteristics of the medical support for personnel landing in a high
      mountainous region].

PMID- 1014373
TI  - [Military medical training is an effective means of consolidating the practical
      skills of rendering medical first aid].

PMID- 1014374
TI  - [Some problems in the morale and psychological training of hospital personnel
      through drill experience].

PMID- 1014375
TI  - [Military patriotic work experience in a medical institute].

PMID- 1014376
TI  - [Urgent problems in the prevention of digestive organ diseases].

PMID- 1014377
TI  - [Organization of the dispensary observation and antirelapse treatment of peptic
      ulcer].

PMID- 1014378
TI  - [Prevention and treatment of infected wounds at medical evacuation centers].

PMID- 1014379
TI  - [Disorder of the blood coagulation system in severe craniocerebral injuries].

PMID- 1014380
TI  - [Diagnosis and surgical treatment of wounds of the heart].

PMID- 1014381
TI  - [Choice of an effective resuspending solution for thawed washed erythrocytes from
      cadaver blood].

PMID- 1014382
TI  - [Acute radiation lesions from the early products of nuclear fission].

PMID- 1014383
TI  - [Hygienic control over the chemical factors in the work environment].

PMID- 1014384
TI  - [Content of fatty components in the blood in persons of different ages].

PMID- 1014385
TI  - [Anesthesia methods in operations performed on board ship].

PMID- 1014386
TI  - [Fat embolism of the cerebral vessels].

PMID- 1014387
TI  - [Case of effective radiotherapy of recurrent otoliquorrhea].

PMID- 1014388
TI  - [Plamimetric determination of the total capacity and residual volume of the
      lungs].

PMID- 1014389
TI  - [Obtaining desalinized water for injection solutions].

PMID- 1014390
TI  - [Preservation of medical stores by a heat sealing method].

PMID- 1014391
TI  - [Occupational training of naval physicians at the level of contemporary demands].

PMID- 1014392
TI  - [Micromethod of determining fibrinogen].

PMID- 1014393
TI  - [Prevention of scabies].

PMID- 1014394
TI  - [Characteristics of the course and prevention of skin diseases in a hot humid
      climate].

PMID- 1014395
TI  - [Functional characteristics of bronchial asthma in young people (Bulgarian
      People's Republic)].

PMID- 1014396
TI  - [Needle holder for Ilizarov's apparatus].

PMID- 1014397
TI  - [Device for holding transducers for electronystagmography].

PMID- 1014398
TI  - [Probe for terminal anesthesia of the throat, pharynx and esophagus in
      gastroscopy].

PMID- 1014399
TI  - [Booth for winter heliotherapy].

PMID- 1014400
TI  - [Achievements of the medical industry of the Hungarian People's Republic].

PMID- 1014401
TI  - [Pension security for workers in military medical institutions].

PMID- 1014402
TI  - [Peacetime pharmaceutical activity and national defense].

PMID- 1014403
TI  - [Various elements in the assessing possibilities of the production of medical
      materials and equipment for national defense].

PMID- 1014404
TI  - [Results of compression osteosynthesis in the treatment of femoral neck
      fractures].

PMID- 1014405
TI  - [Congenital anomalies of the kidney and incidence of pyelonephritis].

PMID- 1014406
TI  - [Conductometric determination of various alkaloid salts in dimethyl sulfoxide].

PMID- 1014407
TI  - [Changes in the ecology of infection and various problems of antimicrobial
      therapy and prevention].

PMID- 1014408
TI  - [Cardiogenic shock following acute myocardial infarct (current attitudes on
      pathology, physiopathology and therapy)].

PMID- 1014409
TI  - [Basis for standards in sanatorium-health resort services to children with
      diseases of non-tuberculous etiology].

PMID- 1014410
TI  - [Rest as a social and medical category].

PMID- 1014411
TI  - [Sanatorium-health resort selection of patients with chronic dermatoses].

PMID- 1014412
TI  - [Hydro-mineral resources of the Far East USSR and prospects for their therapeutic
      use].

PMID- 1014413
TI  - [Effect of electrosleep on the sympathetic-adrenal system of patients with
      ischemic heart disease associated with angina pectoris].

PMID- 1014414
TI  - [Worthy encounter with the XXVth Congress of the CPSU].

PMID- 1014415
TI  - [Use of electrosleep in the early stage of post-hospitalization medical
      rehabilitation of myocardial infarct patients].

PMID- 1014416
TI  - [Relationship between rehabilitation problems and prospects for increasing the
      duration of space flights].

PMID- 1014417
TI  - [Pathogenesis of hypotension and character of the physiotherapy employed].

PMID- 1014418
TI  - [Dynamics of the functional state of the heart in rheumatic patients with
      different methods of fangotherapy at health resorts].

PMID- 1014419
TI  - [Role of therapeutic exercise in the complex health resort therapy of rheumatic
      patients with minimal activity of the process].

PMID- 1014420
TI  - [Novocaine diadynamophoresis in the rehabilitation of patients with absolute
      painful glaucoma].

PMID- 1014421
TI  - [Clinico-morphologic parallels of deforming osteoarthrosis].

PMID- 1014422
TI  - [Effect of different therapeutic-sanatorial complexes of the Poliana health
      resort on patients with chronic cholecystitis].

PMID- 1014423
TI  - [Organization of the work of balneo-hospitals outside health resorts].

PMID- 1014424
TI  - [Detection of diseases of the female genital organs not indicated for health
      resort treatment].

PMID- 1014425
TI  - [The chief physiotherapist].

PMID- 1014426
TI  - [Therapeutic effect of radon baths of different concentrations in inflammatory
      and dystrophic diseases].

PMID- 1014427
TI  - [Clinico-physiological characteristics of the effect of radon baths of different
      concentrations on patients with arteriosclerosis of various localization].

PMID- 1014428
TI  - [Comparative study of the effect of radon baths of different concentration on the
      bioelectric activity of the brain and cerebral hemodynamics in patients with
      cerebral arteriosclerosis with transient disorders of cerebrovascular
      circulation].

PMID- 1014429
TI  - [Results of the study of the effect of radon baths of different concentration on
      patients with arteriosclerotic occlusions of the peripheral arteries, varicose
      veins and postthrombotic disease].

PMID- 1014430
TI  - [Effectiveness of radon baths of different concentration in the treatment of
      cervical osteochondrosis with the vertebral artery syndrome].

PMID- 1014431
TI  - [Treatment of osteoarthritis deformans with radon baths of high concentration
      (200 and 400 nCi/1].

PMID- 1014432
TI  - [Mechanism of the action and the effectiveness of radon treatment of rheumatoid
      arthritis of varied activity].

PMID- 1014433
TI  - [Effectiveness of treatment of rheumatoid arthritis with radon baths of different
      concentration].

PMID- 1014434
TI  - [Comparative effectiveness of the use of radon baths of concentrations 40 and 200
      nCi/1 in the treatment of ankylosing spondyloarthritis].

PMID- 1014435
TI  - [Effect od radon baths on the mast cell-blood heparin system in immunized
      animals].

PMID- 1014436
TI  - [Comparative evaluation of the effect of radon baths of different concentration
      on the course of chronic inflammatory diseases of female internal genital organs
      with regard to the state of the sympathetic-adrenal system and the adrenal cortex
      function].

PMID- 1014437
TI  - [Stimulation method of electrodiagnosis and its comparative evaluation in
      injuries of the peripheral nerves of the limbs].

PMID- 1014438
TI  - [Effectiveness of novocaine diadynamophoresis in the treatment of postoperative
      pain after lung surgery].

PMID- 1014439
TI  - [Exercise therapy in a swimming pool as a method for prevention of exacerbations
      and treatment of chronic nonspecific pneumonia].

PMID- 1014440
TI  - [Radon baths in the treatment od ischemic heart diseases].

PMID- 1014441
TI  - [Effectiveness of sanatorium-health resort treatment of chronic cholecystitis
      (according to remote results)].

PMID- 1014442
TI  - [Effect of ultra-high-frequency electric field on the blood coagulation system in
      animals].

PMID- 1014443
TI  - [Stabilization of iron compounds in mineral waters].

PMID- 1014444
TI  - [Method of graduation of devices used for determination of radon content of water
      after gamma irradiation].

PMID- 1014445
TI  - [Use of ultrasonics in complex treatment of ankylosing spondylarthritis].

PMID- 1014446
TI  - [Prospects for increasing the effectiveness of physiotherapy in therapeutic
      preventive and sanatorium-health resort institutions].

PMID- 1014447
TI  - [Possible role of catalase in the response of mitochondria to helium-neon laser
      radiation].

PMID- 1014448
TI  - [Method of euphylline electrophoresis].

PMID- 1014449
TI  - [Quantitative study of analgin phonophoresis].

PMID- 1014450
TI  - [Several cellular mechanisms of action of ultrasound].

PMID- 1014451
TI  - [Effect of adrenaline electrophoresis on cerebral circulation in patients with
      the hypothalamic syndrome (according to ophthalmodynamometry findings)].

PMID- 1014452
TI  - [Value of complex treatment of patients with deforming osteoarthrosis
      (inductothermy or sinusoidal modulated current and radon baths) in increasing
      therapeutic effectiveness].

PMID- 1014453
TI  - [Medico-economic basis for health resort treatment of patients with joint
      diseases].

PMID- 1014454
TI  - [Effect of health resort treatment on the time of recognition of contour images
      by patients with inflammatory and dystrophic diseases of the joints, chronic
      gastritis and chronic cholecystitis].

PMID- 1014455
TI  - [Methods of medical physiculture for injuries to the lumbosacral region of the
      spine and spinal cord].

PMID- 1014456
TI  - [Treatment of children with chronic hematogenous osteomyelitis in the specialized
      sanatorium "Ozero Gor'koe"].

PMID- 1014457
TI  - [Effect of health resort factors on the anatomic-functional rehabilitation of the
      hip joint following surgical treatment of congenital dislocation of the hip].

PMID- 1014458
TI  - [Effect of inductothermy on indices of the bioelectrical activity of muscles and
      peripheral circulation in children with cerebral palsy].

PMID- 1014459
TI  - [Effect of inductothermy of the adrenal region on the functional state of the
      pituitary-adrenal system in true eczema and neurodermatitis in young children].

PMID- 1014460
TI  - [Health resort treatment of patients with neuroses in the climacteric period].

PMID- 1014461
TI  - [Treatment of patients with cerebral atherosclerosis at the Belokurikha health
      resort].

PMID- 1014462
TI  - [Training of therapist-assistants at the Angara health resort].

PMID- 1014463
TI  - [Barotherapy in the complex treatment of patients with obliterating
      atherosclerosis of the vessels of the lower extremities].

PMID- 1014464
TI  - [Balneopathologic reaction in patients with obliterating diseases of the
      peripheral arteries at the Belokurikha health resort].

PMID- 1014465
TI  - [Treatment of patients with vibration disease with North Osetian volcanic mud
      "tereklit"].

PMID- 1014466
TI  - [Use of turpentine baths with white emulsion in hospitals for chronic diseases of
      the joints and spine].

PMID- 1014467
TI  - [New approaches to the successful use of physical methods of treatment in active
      inflammatory and dystrophic forms of disease].

PMID- 1014468
TI  - [Mechanism of the toxic action of the mycotoxin of Fusarium sporotrichiella].

PMID- 1014469
TI  - [Effect of kynurenine and its metabolites on the concentration of 11
      hydroxycorticosteroids in rat plasma].
AB  - Injections of kynurenine (10 and 25 mg/kg, i.p.) and nicotinic acid (50 mg/kg
      i.p.) produced a marked increase in concentration of 11-hydroxycorticosteroids
      (11-HCS) in rat blood plasma. Effect of nicotinic acid was not prevented by
      dexamethazone (0.6 mg/kg). Subtreshold dose of nicotinic acid (10 mg/kg) enhanced
      a rise in 11-HCS produced by swimming stress. 3-hydroxykynurenine, 3
      hydroxyanthranilic, antranilic picolinic and quinolinic acids (10-50 mg/kg) did
      not change the concentration of 11-HCS. It is suggested that some of the
      biochemical and pharmacological effects of injected kynurenine can be mediated
      through the rise of 11-HCS in blood.

PMID- 1014470
TI  - [Characteristics of different classes of RNA in human leukocytes].

PMID- 1014471
TI  - [Human erythrocyte lipid peroxidation in different pathologic states].
AB  - Various capacity to reactions of peroxidative oxidation was found in lipids from
      erythrocytes of patients with impairments of inflammatory and tumoral nature. The
      most reactive were lipids from erythrocytes of patients with inflammation; lower
      capacity of lipids to peroxidative oixidation was observed in the blood cells of
      patients with tumors. The intensity of reactions of lipid peroxidation had a
      reverse correlation with the stability of erythrocyte membranes in isotonic
      buffer pH 3.0.

PMID- 1014472
TI  - [Noradrenaline concentration and monoamine oxidase activity in regions of the
      brain and the livers of hyperoxic rats].
AB  - Content of noradrenaline and the activity of mitochondrial monoamineoxidase (MAO)
      were studied in cerebral cortex, hypothalamus, mesencephalon, medulla oblongata
      and liver tissue after the oxygen treatment under pressure (4 atm) within 1 hr.
      Content of noradrenaline was decreased in all the brain and liver tissues
      studied. The most distinct decrease was found in hypothalamus and the less marked
      one -- in liver tissue. The MAO activity was increased slightly in hypothalamus;
      it was unaltered in cerebral cortex (as compared with control), decreased
      distinctly in mesencephalon and inhibited by 100% in medulla oblongata. In the
      general brain preparation the MAO activity was considerably decreased. The
      decrease of the enzyme was less pronounced in liver tissue as compared with
      brain.

PMID- 1014473
TI  - [Quantitative histochemical study of fatty acid oxidation in the myocardium and
      skeletal muscles of rats under physical stress].

PMID- 1014474
TI  - [Relationship between the structural state of chromatin and the biosynthesis of
      rapidly labeling nuclear RNA in the thymuses of rats subjected to total x
      irradiation].
AB  - Accumulation of polydeoxyribonucleotides (PDN) was studied in thymus of rats,
      subjected to total body X-ray irradiation at doses 400 and 800 rad. The content
      of PDN correlated with the time of treatment; its low-polymer components
      prevailed after irradiation with 800 rad. Protein/DNA ratio was decreased in DNP
      within 30 min after the irradiation and it returned to the initial level within 4
      hrs. Capacity of DNP to make a complex with actinomycin D was inhibited within 30
      min; however it exceeded the control level within 4 hrs after irradiation.
      Biosynthesis of nuclear RNA, estimated by incorporation of 14C-uridine, was
      distinctly decreased within the whole experimental period.

PMID- 1014475
TI  - [Chemical composition of casein glycomacropeptide components].
AB  - Alteration in pH and addition of urea (final concentration 3 M) did not affect
      the electrophoretic and chromatographic separation of glycomacropeptide. At the
      same time, urea (5 M) distinctly increased an amount of beta-component in
      separation by free electrophoresis. Sedimentation constant SO2OW and molecular
      weight of glycomacropeptide were equal to 1.35 S and 13000, respectively. Both
      fractions of glycomacropeptide had similar amino acid composition and contained
      phosphorus (0.4%). The variations were observed in the carbohydrate components of
      the molecules. The heavy component contained 5-fold higher concentration of
      sialic acids (9.7-9.6%), 2-fold higher concentration of galactose (13%) and
      acetyl galactosamine (5.0-4.0%) as compared with the beta-component (3.1-0.9%,
      7.5% and 2.5%, respectively). These alterations in carbohydrate component of
      glycomacropeptide were suggested to affect the polymeric conformation of the
      molecule.

PMID- 1014476
TI  - [Native and artificial sub-forms of cytoplasmic aspartate transaminase from swine
      heart].
AB  - Multiple forms of aspartate transaminase from cytosol of pig heart (alpha, beta
      and psi) were incubated in 0.05 M acetate buffer, pH 5.0 at 4 degrees within 5
      and 8 months. Gradual accumulation of denaturated forms was observed on
      incubation of alpha- and beta-forms; these forms possessed higher mobility in
      polyacrylamide gel disc electrophoresis and decreased enzymatic activity as
      compared with the native forms. Multiple forms, produced during ageing of alpha
      form, were separated by chromatography on CM-cellulose. Chromatographic
      resolution of the forms, their activity and spectral properties suggest that they
      are not identical with the native isoenzymes found in the cell.

PMID- 1014477
TI  - [Tissue metabolism of thyroid hormones in cirrhosis of the liver].
AB  - Content and ratio of products of iodothyronine tissue metabolism was studied in
      liver tissue of rats in normal state and in hepatocirrhosis after administration
      of 125I-thyroxin. The distinct decrease was observed in accumulation,
      deiodination and conjugation of thyroxin; the hormone was also converted into
      triiodothyronine in cirrhotically altered liver tissue. The importance of liver
      tissue in maintenance of hormonal homeostasis and biological activation of
      thyroid hormones is discussed.

PMID- 1014478
TI  - [Methylation of endogenous DNA in isolated rat liver nuclei and mitochondria].

PMID- 1014479
TI  - [Regulation of peroxidation of mitochondrial membrane lipids initiated by Fe2+
      ions by antoxidants of the 1,4-dihydropyridine series in experiments in vitro].
AB  - Effect of antioxidants on the rate of free radical peroxidation was studied in
      mitochondria in presence of Fe2+. For this purpose derivatives of 1,4
      dihydroxypyridine, their heteroaromatic analogues, NAD-H+ and butyl
      hydroxytoluene (35 substances) were tested in the system by chemoluminescence.
      Several 1,4-dihydroxypyridine derivatives were found to be effective reagents in
      the system and could be compared by the activity with the recognized synthetic
      antioxidant butyl hydroxytoluene.

PMID- 1014480
TI  - [Effect of fat loading on the development of silicosis].
AB  - Rats were administered with quartz dust intratracheally or subjected to chronic
      inhalation of the dust. Peroral overloading of rats with fat was shown to
      increase an accumulation of all lipid fractions in lungs and intensified
      silicotic fibrinogenesis. Similar alterations in lipid metabolism of lungs were
      observed in control animals maintained without the dust treatment at the same
      fatty diet; but these patterns were less distinct and were not accompanied by an
      increased collagene formation. Alterations in content of lipids in liver tissue
      and in blood did not depend on the dusting of lungs under fatty loading. Within
      the later period of inhalational dusting the increased accumulation of quartz was
      observed in lung tissue of rats maintained at fatty diet. The data obtained
      suggest that the recommended by some investigators increase in content of fats in
      miner's diet is not justified.

PMID- 1014481
TI  - [Tryptophan metabolism in vitiligo].
AB  - An activity of tryptophan pyrrolase was not observed in skin of healthy persons
      and of patients with vitiligo. Content of serotonin was similar in skin of normal
      persons and in skin of patients with normal pigmentation and in depigmented area.
      But content of serotonin in blood and excretion of anthranilic acid were
      decreased in the patients as compared with healthy persons. Excretion of
      kynurenine, 3-hydroxykynurenine, 3-hydroxyanthranilic acid, kynureninic,
      xanthurenic and 5-hydroxyindolyl acetic acids was increased in patients and this
      increase was more distinct after loading with 1-tryptophan. The data obtained
      suggest that kynurenine and serotonin pathways of tryptophan metabolism were
      intensified in vitiligo.

PMID- 1014482
TI  - [Pseudouridine and uric acid excretion in patients with viral hepatitis].
AB  - Daily excretion of pseudouridine and uric acid with urine was studied in healthy
      persons and in patients with viral hepatitis during various periods of the
      disease. Excretion of pseudouridine was increased 2.5-fold and of uric acid--2
      fold within the acute period of the disease. The degree of impairment in nucleic
      acids metabolism could be estimated by measuring of excretion of pseudouridine
      and uric acid and by calculation of their ratio during various periods of the
      disease.

PMID- 1014483
TI  - [In vitro metabolism of ubiquinone and ubichromenol in the livers of rats with
      avitaminosis E during individual and combined addition of alpha-tocopherol and
      phenylalanine].
AB  - A maximal incorporation of 2-14C-acetate into ubiquinone and ubichromenol was
      found within 3 hrs if liver tissue homogenate of E-avitaminous rats was incubated
      for 4 hrs. Phenylalanine, added to the mixture, stimulated the biosynthesis of
      ubiquinone and ubichromenol in the liver tissue preparations. alpha-Tocopherol
      caused an increase in biosynthesis of ubiquinone and a decrease in the rate of
      ubichromenol biosynthesis within 1 hr and 3 hrs of incubation in vitro. The
      combined addition of phenylalanine and alpha-tocopherol, almost without
      exceptions, increased the effect of alpha-tocopherol on biosynthesis of the
      substances studied. Interrelationship is discussed between vitamin E and
      ubiquinone and ubichromenol biosynthesis.

PMID- 1014484
TI  - [State of the kinin system in burn shock and early toxemia].
AB  - State of kinin system was studied in blood serum of patients with burns of II,
      III, IIIb and IV degrees during shock and early toxemia. Content or activity of
      main components of kinin system (kininogen, kallikreinogen, kallikrein, kininase
      I (carboxypeptidase N)) were repeatedly estimated at 4-6 hrs intervals; BAEE
      esterase and antitryptic activities were also studied within 48-72 hrs after the
      trauma. At the same period plasminogen and plasmin were estimated in 8 patients.
      The activation of kinin system in burn shock was demonstrated: content of
      kininogen was decreased on 30-50% (independently on alteration of total protein
      in blood serum), the kininase activity was decreased, appearance of free
      kallikrein was observed and content of kallikreinogen was distinctly lowered
      already within 10-24 hrs after the trauma. Within 24 hrs after the burn the total
      decrease of kininogen in circulation accounted for 50-70% of the theoretical
      content. Fibrinolytic system was also activated during the burn shock. Increase
      in the antitryptic activity within 30-40 hrs after the trauma, which was
      previously established, is corroborated; the effect correlated with development
      of burn intoxication. The data obtained suggest that massive production of free
      kinins occur apparently within 24-48 hrs after burn.

PMID- 1014485
TI  - [Method of determining the intregral activity of catechol-O-methyltransferase in
      the human body in vivo].
AB  - A method is developed for estimation of the catecholamine-O-methyl transferase
      activity in human organism by excretion with urine of unmetabolized isadrine (N
      isopropyl noreadrenaline) after loading. Excretion of isadrine was increased both
      after administration of apomorphine, which is one of the inhibitors of the enzyme
      catecholamine-O-methyl transferase, and in cases of liver tissue pathology. It is
      known that the maximal activity of catecholamine-O-methyl transferase is the
      highest in liver tissue. Imipramine (an inhibitor of uptake of catecholamine) did
      not inhibit the activity of cafecholamine-O-methyl transferase as estimated by
      the present method.

PMID- 1014486
TI  - [Fractionation of DNA on unmodified cellulose].
AB  - Not only separation of native, two-stranded DNA from denatured molecules but more
      distinct fractionation of single-stranded DNA was demonstrated on unmodified
      powdery and microgranular cellulose. Denatured DNA, absorbed on cellulose, was
      eluted from a column as two asymmetric peaks by 0,12 M and 0.05 M NaCl (for I and
      II peaks, respectively). Absorption and fractionation of denatured DNA and poly-A
      containing RNA on unmodified cellulose was apparently achieved on the basis of
      the same principles.

PMID- 1014487
TI  - [Cell immunity indices in carcinoma of the gastrointestinal tract].
AB  - A group of 137 patients with carcinoma and benign diseases of the
      gastrointestinal tract was tested for a specific immunity to tumor, mucosa
      antigens and PHA. A response of peripheral blood lymphocytes to PHA was
      suppressed in patients with cancer. An assay of the specific reactivity against
      tumor antigens was done either by a lymphoblastic transformation or by the
      leucocytes migration inhibition agarose technic. More than one third of cancer
      patients showed positive ractions to tumor extracts in autologous as well as
      allogeneic systems. No differences were noted between the effect of the mucosa or
      tumor extract in a group of benign diseases by migration inhibition technic, but
      there were 11 of 23 patients who showed a blasttransformation reaction to tumor
      antigen. The autologous mucosa extract had no effect on lymphocytes of cancer
      patients, but it was found to inhibit the leucocytes migration. The action of
      tumor extracts was comparable in autologous and allogeneic systems. The presence
      of common or cross-reactive tumor antigens in gastrointestinal cancer is assumed.
      Some possible reasons of the changes are discussed.

PMID- 1014488
TI  - [State of blood basophilic granulocytes in the estimation of sensitization of
      patients with stomach neoplasm].
AB  - One of the methods reflecting the state of antitumor cell immunity is skin
      allergic reaction of delayed hypersensitivity to injection of antitumor antigen,
      which together with other indices is believed to be of certain importance in
      estimating the immune response of the cancer patient organism. The authors
      compared quantitative and morphological changes in blood basophilic granulocytes
      and the data of skin allergic reaction. The results of studies conducted
      indicated that changes in the quantity and degranulation of basophilic leucocytes
      may be used along with skin allergic response of delayed hypersensitivity as one
      of the criteria for estimation of the degree of sensibilization of the organism
      of gastric cancer patients.

PMID- 1014489
TI  - [Antigen, containing tryptophan metabolite, 3-oxyanthranilic acid, in blood serum
      of patients with stomach neoplasms].
AB  - The results of studies of the antigen containing 3-oxyanthranilic acid (3-OAA
      antigen), as one of determinantal groups, in blood serum of patients with tumor
      and pretumor lesions of the stomach indicated that the former is present in the
      majority of patients with cancer proved histologically and also in some patients
      with pretumor diseases of the stomach. 3-OAA-antigen is found to be absent in
      health donors blood serum. The importance of the data obtained for establishing
      an early diagnosis of gastric cancer is discussed.

PMID- 1014490
TI  - [Radioisotope gastroscintigraphy in diagnosis of tumor and pretumor diseases of
      the stomach].
AB  - The results of isotope gastroscintigraphy, performed in 160 patients with tumor
      and pretumor diseases of the stomach, are reported. Based on a clinico
      morphological estimation of gastroscintigraphic findings, it was found that in
      115 (72%) patients the data of scanning coincided with the ultimate diagnosis. In
      25 (16%) patients pseudopositive and in 20 (12%)--pseudonegative scannograms were
      obtained. The greatest number of pseudonegative results was noted in patients
      with gastric cancer (in 19 of 20), in 10 of them tumor being located in the
      cardiac portion of the stomach. The precision of diagnosing tumors in other
      anatomical portion of the stomach was 90%. In patients with pretumor lesions the
      character of scannographic alterations was dependent on the rate of impairment of
      gastric mucosa function and structure.

PMID- 1014491
TI  - [Current questions in the diagnosis and therapy of lymphogranulomatosis].
AB  - A summary of main successes in the field of diagnosis and therapy of
      lymphogranulomatosis is given. The most informative methods of diagnosis that
      need further development are estimated. Therapeutic schemes that are to be
      further pinpointed (radiation, pharmacological and combined) as well as possible
      prospective trends in studying the pathogenesis (the technic of cultivation, an
      estimate of the immunological status) are being formulated, due to that the
      therapeutic policy might be substantially modified.

PMID- 1014492
TI  - [Prognosis in radiotherapy of patients with local recurrence of cervix
      neoplasms].
AB  - An analysis of the results of treatment in 231 patients with recurrences of
      cervical cancer is presented in relation to 5-year survival criterion ("dynamic
      analysis"). An actual 5-year survival rate was 16.0%. The most important factors
      determining the prognosis include the stage of the primary process, localization
      of the secondary tumor, terms of the recurrence and the absorbed dose of
      radiation given to the recurrence. Standardized rates showed a 3-5 fold
      improvement of the results of treatment in the presence of favourable prognostic
      factors. In combinations of favourable prognostic factors the 5-year survival
      rate of patients with recurrent cervical cancer reached 67.0%. The amount of the
      absorbed local dosage of radiation is of practical value for improvement of the
      results of treatment. Radiotherapy is the method of choice in treatment of
      patients with local recurrences of uterine cervix cancer.

PMID- 1014493
TI  - [Cytologic method for determination of histological structure in precancer and
      cancer of the cervix uteri].
AB  - The authors studied comparatively cytologic and histological findings in 164
      patients in whom pretumor lesions (82) and cervical cancer (82) were revealed.
      The precision of cytologic diagnosis of pretumor lesions was 95.1 +/- 4.8%, of
      cancer--91.4 +/- 6.2%. Of 95 observations in which epithelial atypia, from
      proliferation to cancer, was detected the degree of cell atypia was correctly
      determined cytologically in 82.1 +/- 8.1% of observations, the degree of
      differentiation--in 85.2 +/- 7.2%, both factors--in 68.4 +/- 9.5%. Of 67
      observations, in which cervical cancer was correctly diagnosed cytologically, the
      precision of prognosticating the presence of preinvasive and invasive cancer was
      86.5 +/- 8.4%, while the degree of differentiation was diagnosed correctly in
      83.5 +/- 9.0%, the histostructure being determined precisely in 71.6 +/- 11%.

PMID- 1014494
TI  - [Use of lophenal in patients with malignant ovarian tumors].
AB  - The use of lophenal in complex treatment of 27 patients with malignant ovarian
      tumors has shown that the substance possesses a definite antitumor activity,
      manifested in gaining the clinical effect in 60.9% of patients with an average
      duration of remission lasting for 5.3 months. The toxic effect on hemopoiesis as
      well as the side effect of the substance were liquidated by pharmacological
      drugs. It is concluded that lophenal should be used along with other
      chemotherapeutic drugs for treatment of patients with malignant ovarian tumors.

PMID- 1014495
TI  - [Effect of N-nitroso-N-methylurea on DNA and RNA synthesis in cells of liver and
      spleen tumors in leucosis L-1210].
AB  - During the development of leucosis a progressively retarded incorporation of 2
      C14-thymidine and C14-uridine into DNA and RNA of a separate tumor cell and an
      active incorporation of 2-C14-thymidine into DNA of hepatic and splenic cells
      were observed. Repeated injections of NMU (20 mg/Kg X 5) in tumor-bearing animals
      result in a twice increase of life terms in mice and suppression of total tumor
      cells growth. The observed therapeutic effect is related with deep inhibition of
      DNA and RNA synthesis in leucosis L-1210 cells, while DNA synthesis in hepatic
      and splenic cells is only insignificantly suppressed (compared with the normal
      level typical for intact animals), but RNA synthesis in these organs is actually
      not involved.

PMID- 1014496
TI  - [Study of the factor of ascites fluid of Erlich tumor].
AB  - The factor of nucleic nature was isolated by phenol method from acellular ascitic
      fluid of Ehrlich tumor. DNA was found to be the main component of the factor
      concerned as indicated by chemical analysis after its purification with
      preparative electrophoresis in 2.5% polyacrylamid gel or centrifugation in CsCl
      gradient. Moreover, the factor can be destroyed in incubation with DNA-s. It is
      not improbable that this factor consists also of small amounts of RNA.

PMID- 1014497
TI  - [Bifunctional derivatives of N-nitroso-alkylurea].
AB  - Toxic cumulative and antitumor properties of bifunctional N-nitroso-alkylureas as
      compared with their monofunctional analogues were stuied. Newly produced
      compounds render a considerable antitumor effect on a number of experimental
      tumors. A conclusion may be drawn that despite changes in the chemical structure
      an active metabolic fragment both of mono- and bifunctional compounds is the
      same, as also evidenced by the cumulation index. However, inspite of a rather
      high antitumor activity of bifunctional compounds their chemotherapeutic indices
      are very low.

PMID- 1014498
TI  - [Impairment of DNA synthesis under influence of antifolic substance, tomizine].

PMID- 1014499
TI  - [Rheography in differential diagnosis of pulmonary cancer].

PMID- 1014500
TI  - [Renal function and water-salt metabolism in patients with cervix neoplasms].

PMID- 1014501
TI  - [Study of possible carcinogenic properties of flexographic dyes].

PMID- 1014502
TI  - [Possibility of tissue accumulation and elimination of 3,4-benzpyrene from the
      bodies of fish].
AB  - One-year and two-year iridescent trout and two-year carp during different periods
      (from 2 months to 1 year) were given protein-vitamin addition to food containing
      3,4-benz-pyrene (BP). The total amount of BP entering the organism of fish for
      the whole period of the experiment reached 12,6 mg/Kg of fish weight in daily
      dosage ranging from 0.1 to 4.1 m/Kg. In fish tissues BP was either not detected
      at all, or the content of the carcinogen in them did not exceed its amount in the
      control. In summer BP was not excreted in feces, but in winter its excretion made
      13% of its daily consumption with food.

PMID- 1014503
TI  - [Problems concerning metastasis of malignant tumors].
AB  - The data on metastases incidence in new discovered patients with malignant tumors
      of general localizations are presented. The status of current investigations on
      the ways and mechanisms of metastases, as the basis for elaborating measures of
      their prevention, is characterized. The most effective methods of diagnosis and
      treatment of regional and distant metastases are described. Special attention is
      given to the necessity of using combined and complex treatment of metastatic
      forms of malignant tumors. It is shown, that along with the widely used methods,
      the application of radioisotopic, hormonal and some physicochemical influences,
      hyperthermia and hyperglycemia in particular, seems to be quite promising for
      this purpose.

PMID- 1014504
TI  - [Surgical treatment of precancerous diseases of the stomach].
AB  - In benign solitary polyps of the stomach the author recommends to perform
      polypectomy. Observations of 26 operated patients during the period from 1 to 10
      years revealed neither polyps recurrence nor cancer. According to the author's
      data malignization of callous gastric ulcers was found in 10-26% by histological
      assays of the resected specimens. To the end of prophylaxis against cancer the
      author considers it necessary to widen indications to surgical treatment of
      gastric ulcers.

PMID- 1014505
TI  - [Immediate and remote results of surgical, chemotherapeutic,radiation, combined
      and complex treatment of patients with serous cystadenocarcinoma of the ovaries].

PMID- 1014506
TI  - [Cytospectrophotometric study of DNA concentration in interphase nuclei of buccal
      smears from women with breast cancer].

PMID- 1014507
TI  - [Diagnostic value of determining spermidine in the urine of patients with
      melanoblastoma of the skin].
AB  - To estimate the diagnostic value of determination of one of polyamines
      (spermidine) in the urine the authors examined 58 patients with skin
      melanoblastomas of different localization and 10 healthy persons. It was found
      that in 16 of 25 patients having only primary tumor, in all 9 patients having
      primary tumor with metastases in regional lymph nodes, and also in 14 of 20
      patients, who after previous therapy developed recurrence or metastases in
      regional lymph nodes, spermidine excretion exceeded its normal level. In three
      patients, subjected previously to radical treatment and considered as being
      clinically recovered, normal spermidine level was excreted. The data obtained
      enabled the authors to use this test as an adjuvant criterion in examination and
      treatment of such patients.

PMID- 1014508
TI  - [Variants in the course of papillary carcinoma of the thyroid gland (clinico
      morphologic analysis)].
AB  - A clinico-morphological analysis of 157 cases of papillary cancer of the thyroid
      is made. Depending on the presence and time of appearance of regional metastases
      three groups of patients are distinguished: I -- regional metastases are the
      first clinical manifestation of the lesion (87 patients); II -- the lesion starts
      with the appearance of a node in the gland, regional metastases develop later (50
      patients); III -- thyroid tumor without regional metastases (20 patients). The
      groups sungled out differ reliably in the rate of tumor growth and prognosis. The
      first group proved to be most favourable with respect to prognosis. A five-year
      survival in patients of the first group was noted in 92 +/- 3.3%, while 84 +/-
      7.4% of patients survived for 10 years and longer. There were no essential
      differences in the morphological signs in the concerned clinical groups of
      papillary cancer of the thyroid.

PMID- 1014509
TI  - [Classification of infiltrative-edematous forms of breast cancer according to the
      TNM system].

PMID- 1014510
TI  - [3-Hydroxyanthranilic acid in the blood of patients with kidney tumors].
AB  - Antigen containing the tryptophan metabolite -- 3-oxyanthranilic acid-(3-OAA
      antigen) was determined by agarose precipitation method, using specific immune
      rabbit sera in 85 patients, admitted with the primary diagnosis of renal tumor.
      Among 85 patients 3-OAA-antigen was found in blood sera in 62 patients. Among 23
      patients in whom 3-OAA-antigen was not revealed in 20 -- the diagnosis of renal
      tumor failed to be supported. The authors conclude, that it is possible to use
      the reaction of 3-OAA-antigen detection for establishing the diagnosis of tumors
      of the kidneys.

PMID- 1014511
TI  - [Means of dissecting the tentorilm cerebelli following cranio-cerebral trauma].
AB  - Circulatory disorders in the brain stem due to temporal herniation are among the
      leading causes of death of patients with craniocerebral injuries. The dissection
      of the cerebellar tentorium following the removal of a space occupying formation
      aimed at decompressing the brain stem is a rather traumatizing procedure. A less
      traumatizing method of tentorial dissection was developed using a specially
      designed instrument. Fifteen operations were conducted in 14 patients.

PMID- 1014512
TI  - [Relationship between combined injuries of the skull and chest and the type of
      the injury].

PMID- 1014513
TI  - [Alteration of the visual evoked potential following concussion].

PMID- 1014514
TI  - [Surgical treatment of thromboembolism of the median cerebral artery].

PMID- 1014515
TI  - [State of the sympathetic orbito-pupillary innervation in facial pain syndromes].
AB  - In 55 patients with trigeminal pain syndromes of different genesis a study of the
      state of the orbit-pupillar innervation was undertaken judging by the response to
      sympathomimetic drugs (adrenalin and cocaine solutions) administered into the
      conjunctival sack. The obtained data were evaluated by way of pupillography. The
      disorders in sympathetic orbit-pupillary innervation were found to be independent
      of a prevailing lesion of any of the three peripheral branches of the trigeminal
      nerve. Trigeminal neuralgias develop without any disorders in the sympathetic
      orbit-pupillary innervation. In the presence of a neuritic component in
      trigeminal pains the disorders in the sympathetic orbit-pupillary innervation are
      noted invariably. In anaesthesia dolorosa of the face an important place in the
      genesis of the pain syndrome belongs to the cranial portion of the sympathetic
      nervous system.

PMID- 1014516
TI  - [Clinico-electrophysiologic studies of the spastic syndrome and its neurosurgical
      treatment in patients with spinal cord lesions].
AB  - The authors analyse the results of surgical treatment of spastics in 15 patients
      with spinal cord lesions. The results of a dynamic, neurological and
      electrophysiological examinations permit to draw several conclusions on the
      mechanisms of spasticity and its elimination by surgery. A restoration of reflex
      activity in the absence of the spastic syndrome is considered by the authors as a
      favourable result of the operation.

PMID- 1014517
TI  - [Two-dimensional echoencephalography in focal brain pathology].
AB  - Two-dimentional echoencephalographic examinations were conducted in 35 patients
      with focal lesions of the brain of different etiology. Normal
      tomoechoencephalogramme and ultrasonic semiotics of transverse sections of the
      brain in different pathology is described with reference to its nature and
      interrelationships with the meninges and brain matter (tumours, abscesses,
      emningeal and intracerebral haematomas, hydroma, brain confusion, intracranial
      foreign bodies). The authors believe that two-dimentional echoencephalography is
      a promising method of diagnosis, free of contraindications, combinding safety and
      promptness of the examination. direct visualization of focal pathology of the
      brain through an intact skull.

PMID- 1014518
TI  - [New way to protect the membranes of the eye in paralysis of the facial nerve].

PMID- 1014519
TI  - [An addition to the electroencephalography for recording local blood flow and
      cerebral p02].

PMID- 1014520
TI  - [Instrument for applying temporary clips].

PMID- 1014521
TI  - [Comparative study of intracerebral and cerebrospinal fluid pressure in
      neurosurgical clinical practice].
AB  - Comparative measurements of cerebrospinal fluid pressure(CSPF), total local
      intrabrain pressure (IBP) and interstitial fluid pressure(ISFP) have been made in
      32 neurosurgical patients in the postoperative period. The obtained data prove
      that IBP is almost twice higher than ISFP and 1.5 times higher than CSFP. The
      data of this study show that no direct hydrostatic relation exists between the
      cerebrospinal fluid and the interstitial fluid. The reasons of "negative" values
      of ISFP are also discussed. The intracranial pressure is to be considred as a
      combination of selective mechanical pressures of the main intracranial
      components. Therefore a more precise term "intracranial pressures" is suggested.

PMID- 1014522
TI  - [X-ray diagnosis of cranio-vertebral anomalies].
AB  - On the basis of an analysis of the radiological data of 66 patients with
      craniovertebral anomalies the following forms of them were distinguished: 1)
      basilar impression; 2) assimilation of the atlas; 3) coarctation of the atlanto
      occipital segment; 4) anomaly of the C1-dens. The main radiological signs
      revealed in the patients with different forms of craniovertebral anomalies with
      the aid of craniometric techniques and linear and angular indices are presented.
      The importance of tomography and myelography in the diagnosis of medullar
      compression and of its concomitant anomalies is emphasized, pneumomyelography
      being preferred against positive myelography. A combined evaluation of the
      neurological and radiological data permits to determine the indications for
      surgery of congenital craniovertebral pathology.

PMID- 1014523
TI  - [Congenital disorders in the stability of the cranio-vertebral region].
AB  - A functional radiographic examination of the craniovertebral zone was conducted
      in 600 normal adults and in 15 children. Normal peculiarities of the
      interrelationship of the atlantoaxial articulation found in 542 persons were
      classified. In 58 of them (9.7%) excessive mobility of the atlantoaxial
      articulations was found, 50 of them having a subluxation of the Cruveilhier joint
      with a dynamic narrowing of the vertebral canal. The remaining 8 persons had an
      excessive mobility of C1 along the axis of the dens of C2 overlapping half of the
      anterior arch of C1 above the apex of C2-dens. Such chronic disorders in the
      interrelationship of the craniovertebral zone elements caused no neurological
      disorders. However, in unfavourable cases, like forced movements of the head, a
      severe acute pathogenetic neurological situation may occur.

PMID- 1014524
TI  - [Subclinical forms of spinal disorders in discogenic lumbar radiculitis].
AB  - In patients with discogenic lumbar radiculitis with a unilateral affection of L5
      or S1 root motor and central responses of the medial group of plantar muscles
      were recorded. In S1 root pathology the central response consisted in 25% of the
      cases in repeated antidromal discharges, which testified to an increased
      excitability of the corresponding alpha-motoneurons. In patients with L5
      radiculitis a predominance of the reflex component in the response was typical.
      Since this phenomenon was lacking in combined L5 and S1 root lesions, it was
      interpreted as a sign of a decreasing function of the segmental inhibitory
      interneurons.

PMID- 1014525
TI  - [Clinico-immunologic periods of spinal cord injuries].
AB  - A clinical and immunological periodicity of spinal cord injuries is introduced,
      comprising 5 periods. The periodicity is based on a study of the indices of a
      specific and non-specific immunological reactivity of 150 persons with vertebral
      column traumas accompanied by spinal cord injuries studied after different
      periods following the trauma and compared with the clinical data and results of
      similar examinations in the controls. The clinical and immunological periodicity
      plays an important role in the panning of rational therapy, in the evaluation of
      bacteriuria and the principles of antibacterial therapy, as well as for the
      exaluation of the neurodynamics of the injured spinal cord.

PMID- 1014526
TI  - [Total removal of acoustic neurinoma].
AB  - The analysis is based on the results of a total removal of acoustic neurinomas in
      120 patients operated on in 1967-1975. The facial nerve was preserved after
      surgery in 65 patients (54.2%). In the course of the recent 3 years the
      employment of microsurgical techniques permitted to preserve the VII nerve in 26
      among 35 operated patients (74.3%). Among 103 examined postoperatively 96
      retained their full or partial capacity for work (93.2%). Ten patients (8.3%)
      died after surgery. Within the recent 3 years 35 patients were operated on
      without a single mortality case.

PMID- 1014527
TI  - [Clinical picture of multiple intracranial hematomas in the acute period of
      severe cranio-cerebral trauma].
AB  - According to the authors, the clinical course of multiple intracranial haematomas
      is characterized by a prompt formation of the syndrome of acute brain dislocation
      with the development of severe pyramidal deficit and involvement of the
      oculomotor nerve on the side of the larger intracranial haematoma. To detect the
      multiple haematomas it is recommended to employ, both pre- and post-operatively,
      a careful echoencephalographic and angiographic control in the patients with a
      severe brain trauma.

PMID- 1014528
TI  - [Glycogen breakdown in the tissue of human cerebral glial tumors].
AB  - The activity of gamma-amylase (acid alpha-glucosidase) and phosphorylase in the
      tissue of human glial tumours and the brain tissue adjacent to the tumour was
      studied. A sharp (more than three-fold) increase of the activity of gamma-amylase
      was found in the tissue of glial tumours. In the adjacent tissues of the brain
      its activity was also elevated (approximately, two-fold). The activity of
      phosphorylase is practically lacking in human glial tumours, and is only slightly
      apparent in the brain tissue neighbouring the tumour. Gamma-amylase may be
      suggested to play an important role in glycogen metabolism of glial tumours in
      man.

PMID- 1014529
TI  - [Two-dimensional echoencephalography through a trepan defect in the skull].
AB  - With the aid of a non-adapted equipment echoencephalotomogrammes were obtained
      that revealed fine details of intracranial structures in normals and in patients
      with space-occupying lesions, these tomogrammes being comparable to those
      obtained after anatomic sections of the skull in the same planes. This becomes
      possible thanks to the absence of the bone as a limiting factor. Interpreting the
      conducted examinations as a model of intraoperative scanning, and considering the
      results of experimental craniotomies, a conclusion is made as the importance of
      such investigations especially in cases of bilateral space-occupying lesions.

PMID- 1014530
TI  - [Divergence ultrasound in unidimensional echoencephalography].

PMID- 1014531
TI  - [Diagnosis of unicameral echinococcosis of the brain].

PMID- 1014532
TI  - [Current problems in the diagnosis and treatment of malignant tumors of the brain
      according to findings in the foreign literature].

PMID- 1014533
TI  - [Diagnosis and surgical treatment of hourglass shaped tumors of cervical
      localization].
AB  - Among 449 patients with intravertebral tumours, 35 patients (7.8%) had sand-glass
      shaped tumours, 19 of them being localized in the neck, which comprised 19.6% of
      the 97 cervical intravertebral tumours, and 45.9% of neurinomas. An analysis of
      the material permits to conclude that when the symptoms of spinal cord
      compression are combined with an extension of the intervertebral foramen, the
      indications for myelography for precising the diagnosis are relative. A one-stage
      total excision of the tumour is indicated, either via a vertebral approach, or
      via a bilateral approach by way of laminectomy and from the neck. Whenever the
      intervention has to be divided into two stages, the intravertebral node should be
      removed first, and the extra-vertebral one afterwards from the cervical incision,
      always striving to cut the interval between the two interventions down to 3-4
      weeks.

PMID- 1014534
TI  - [Thrombosis and embolism of the pulmonary artery].

PMID- 1014535
TI  - [Acupuncture in the treatment of bronchial asthma].

PMID- 1014536
TI  - [Use of ethamide in complex treatment of pulmonary tuberculosis].

PMID- 1014537
TI  - [Study of Skibinskii's coefficient in active pulmonary tuberculosis].

PMID- 1014538
TI  - [Use of anaprilin in the treatment of hypothalamic lesions].

PMID- 1014539
TI  - [Age-specific structural changes in the radicular apparatus of the spinal cord].

PMID- 1014540
TI  - [Vitamin B2 metabolism in patients with tumors and inflammatory diseases of the
      brain].

PMID- 1014541
TI  - [Relation between edema and swelling of the brain].

PMID- 1014542
TI  - [State of certain factors of nonspecific immunity in children with cerebral
      palsy].

PMID- 1014543
TI  - [State of the function of external respiration in patients with silicosis working
      at machine-building plants].

PMID- 1014544
TI  - [Reaction of the endocrine system to the effect of an electromagnetic field of
      industrial frequency (50Hz)].

PMID- 1014545
TI  - [Circulating antibodies to chemical substances in allergic stomach diseases].

PMID- 1014546
TI  - [Differential diagnosis of Salmonella food poisoning and the syndrome of
      subarachnoid hemorrhage].

PMID- 1014547
TI  - [Clinical characteristics of icterohemorrhagic leptospirosis].

PMID- 1014548
TI  - [Current concepts on the pathogenesis of ischemic heart disease].

PMID- 1014549
TI  - [Clinical use of benphothiamine].

PMID- 1014550
TI  - [Indicators of the activity of total blood lactate dehydrogenase in rheumatism].

PMID- 1014551
TI  - [Evaluation of the therapeutic effect of dopegit and depressin in hypertension
      according to polycardiographic data].

PMID- 1014552
TI  - [Certain aspects of the effect of strophanthin on hemodynamics in the acute stage
      of myocardial infarct].

PMID- 1014553
TI  - [Clinical evaluation of the study of cardiac antibodies in rheumatism].

PMID- 1014554
TI  - [Effect of depressin and dopegit on pulmonary and liver circulation in
      hypertension].

PMID- 1014555
TI  - [Transient Pelger-Huet anomaly].

PMID- 1014556
TI  - [Effect of meteorological factors of the Zakarpathian region on patients with
      cerebrovascular disorders].

PMID- 1014557
TI  - [Treatment of elderly patients with the cerebral form of hypertension in the
      biotron].

PMID- 1014558
TI  - [Arterial pressure in patients with neurosis-like conditions after infectious
      arachnoencephalitis].

PMID- 1014559
TI  - [Differentiated use of mud therapy in arteriosclerosis obliterans of the
      peripheral vessels].

PMID- 1014560
TI  - [Glutathione level in the venous blood after an operation on the biliary tract].

PMID- 1014561
TI  - [Various problems of stage-by-stage treatment of chronic cholecystitis].

PMID- 1014562
TI  - [Effect of secretin on gastroduodenal motility].

PMID- 1014563
TI  - [Use of endoscopy for diagnosis of peptic ulcer of the gastroenteroanastomosis
      and the jejunum].

PMID- 1014564
TI  - [Method of ballottement of the organs of the abdominal cavity "in suspension"].

PMID- 1014565
TI  - [Use of endoscopy for the diagnosis of precancerous conditions and neoplasms of
      the stomach under ambulatory conditions].

PMID- 1014566
TI  - [Rare case of location of an echinococcal cyst in the retroperitoneal space].

PMID- 1014567
TI  - [Comparative evaluation of x-ray and radioisotope methods of examination in renal
      tuberculosis].

PMID- 1014568
TI  - [Certain immunological indicators in glomerulonephritis at the stage of chronic
      renal failure].

PMID- 1014569
TI  - [Blood coagulation changes in bleeding bronchiectasis].

PMID- 1014570
TI  - [Sea baths in the treatment of patients with chronic pneumonia].

PMID- 1014571
TI  - [External respiration and zonal ventilation in patients with destructive forms of
      pulmonary tuberculosis].

PMID- 1014572
TI  - [Tibon tolerance in patients with tuberculosis and concomitant peptic ulcer and
      chronic gastritis].

PMID- 1014573
TI  - [Effect of various levels of UHF energy on the functional state of the body].

PMID- 1014574
TI  - [Mixed seroconversion in patients with acute respiratory viral infections].

PMID- 1014575
TI  - [Treatment of angina with durable antistreptococcal penicillin preparations].

PMID- 1014576
TI  - [Bases and variations in expert testimony used in public health institutions].

PMID- 1014577
TI  - [Early diagnosis and problems in classification of pulmonary hypertension].

PMID- 1014578
TI  - [Early stages of chronic cerebrovascular insufficiency in atherosclerosis and
      hypertensive disease].

PMID- 1014579
TI  - [Role of alcohol in the development of ectopic arrhythmias].

PMID- 1014581
TI  - [Case of cavernous angioma of the heart].

PMID- 1014580
TI  - [Errors in diagnosis of proctracted spetic endocarditis].

PMID- 1014583
TI  - [Diabetic glomerulosclerosis].

PMID- 1014582
TI  - [State of the cardiovascular system in patients with chronic pancreatitis].

PMID- 1014584
TI  - [Hemocoagulation properties of the endocrine glands].

PMID- 1014585
TI  - [Indices of phosphorus energetic and electrolytic metabolism in patients with
      various functional activity of the thyroid gland].

PMID- 1014586
TI  - [Subacute nonpurulent de Quervain's thyroiditis].

PMID- 1014587
TI  - [Diagnostic value of secretion and concentration of blood cortisol in Itsenko
      Cushing disease].

PMID- 1014588
TI  - [Surgical treatment of patients with uncomplicated gastroduodenal ulcer].

PMID- 1014589
TI  - [Effect of Morshin mineral waters on the hydrolysis of lactose in patients with
      postresection dumping syndrome].

PMID- 1014590
TI  - [Effect of mineral water "Galychanka" on the course of peptic ulcer, chronic
      gastritis, and chronic cholecystitis].

PMID- 1014591
TI  - [Blood serum immunoglobulins in healthy subjects and patients with chronic
      inflammatory diseases of the biliary system and liver].

PMID- 1014592
TI  - [Diagnostic value of tests for estimation of disease activity in patients with
      chronic hepatitis and liver cirrhosis].

PMID- 1014593
TI  - [Secretory and motor-evacuation function of the stomach and duodenum in
      cholecystitis].

PMID- 1014594
TI  - [Therapeutic effect of choleretic drug urocholesan in patients with chronic
      cholecystitis].

PMID- 1014595
TI  - [Effect of amino acids on pharmacological action of cholinomimetic agents].

PMID- 1014596
TI  - [Arterial pressure in middle and old age].

PMID- 1014597
TI  - [Bile composition in patients with chronic cholecystitis].

PMID- 1014598
TI  - [State of the visual organs in hepato-biliary system diseases].

PMID- 1014599
TI  - [Removal of gastric polyps with pedicle electrocoagulation of the pedicle using
      the gastrofibroscope].

PMID- 1014600
TI  - [Functional and morphological changes of cells tumors in gastric cancer].

PMID- 1014601
TI  - [Renal function in associated thoraco-abdominal compression].

PMID- 1014602
TI  - [Endocrine function of the testis in chronic prostatitis].

PMID- 1014603
TI  - [Differential diagnosis of pleurisy in middle-aged and old patients].

PMID- 1014604
TI  - [Pathology of the heart automotor system in acquired disorders of rhythm and
      conductivity].

PMID- 1014605
TI  - [Acute idiopathic pericarditis evolving into constrictive pericarditis].

PMID- 1014606
TI  - [Prognostic value of the ST elevation of the electrocardiogram in the acute stage
      of myocardial infarct].
AB  - The prognostic value of ST segment elevation on electrocardiograms is studied in
      400 patients with acute myocardial infarction, 138 of them deceased. A close
      correlation was established between the degree of ST segment elevation and
      mortality rate. The average value of ST elevation in all deceased is 5.22 +/-
      0.20 mm, und in all survived the acute stage--3.39 +/- 0.15 mm. Those values are
      higher in anterior infarction--5.55 +/- 0.23 mm and 3.99 +/- 0.15 mm and lower in
      posterior infarction 4.45 +/- 0.25 mm and 2.65 +/- 0.10 mm. The ST segment
      elevation over the average values in the deceased is a poor prognostic sign and
      an elevation slightly lower than the average values in the recovered is a
      favourable prognostic sign.

PMID- 1014607
TI  - [Epidemiological studies of ischemic heart disease and arterial hypertension
      among the industrial workers and administrative employees in the "Napreduk"
      factory in Plovdiv].
AB  - Five hundred and ten industry workers and 100 administrative employees from the
      plant "Napredak"--Plovdiv were studied consuming the same quantity of calories
      (from 2500 to 3500). The working processes of the workers are mechanized in 70
      per cent. The production is based on the conveyor system. Reduced physical
      activity is established but intensified psychic strain. Reduced physical activity
      is also established in the administrative employees and high mental loading. All
      men and women, aged 25-75 were examined for ischemic heart disease (IHD). IHD was
      found in 30.59 per cent among the industry workers (31.14 among men and 29.38
      among women). IHD in 48 per cent (41.9 among men and 34.37 per cent among the
      women) was found in the administrative employees. The role of certain risk
      factors for IHD was studied. Arterial hypertension proved to be one of those risk
      factors with statistical significance, as well as obesity, hyperlipidemia (over
      800 mg%), hypercholesteremia (over 250 mg%). Arterial hypertension was confirmed
      in 12.3 per cent of industry workers and in 19 per cent the administrative
      employees. More important and statistically significant factors for it are:
      obesity, hyperlipidemia, hypercholesteremia and neuropsychic strain.

PMID- 1014608
TI  - [Thyrotropic hormone plasma level in thyrotoxicosis].
AB  - Immunoreactive TTH plasma concentration was investigated twice a day (at 9 a.m.
      and 9 p.m.) in 30 patients with thyrotoxicosis, 10 out of them in acute stage and
      20 in a state of remission after thymidazol treatment as well as in 17 healthy
      subjects. The authors established that in the acute state of thyrotoxicosis the
      latter is reduced to low normal or subnormal values (an average of 2.94 +/- 0.70
      ng/ml) and after thyrostatic therapy leading to remission--is about the average
      norm (4.65 +/- 1.10 ng/ml) and does not differ much from that in healthy subjects
      (4.75 +/- 0.92 ng/ml). The negative correlation between the TIH levels and
      thyroid hormones (BOI, total thyroxin), typical for the healthy subjects, is
      found in the patients with acute thyrotoxicosis. No significant difference was
      established between the TTH values of the morning and evening hours in any of the
      groups. The physiological regulatory feedback mechanism in thyrotoxicosis is
      assumed not to be disturbed.

PMID- 1014609
TI  - [Diagnosis of oligosymptomatic forms of chronic glomerulonephritis].
AB  - An investigation is carried out, by punch biopsy, on 54 patients with chronic
      glomerulonephritis, its course being evaluated as oligosymtomatic. From the
      patients followed up 35 were with morphologic changes corresponding to
      endoproliferative type, 13--to membranaceous type and 6--to membranaceous
      proliferative type. The patients' complex investigation (incld. the investigation
      of biopsy renal material) was established to allow the disease diagnosis in its
      initial stage, irrespectively of the lack of manifested clinical and laboratory
      symptoms. Some typical peculiarities in the clinical course and the differences
      of the followed up laboratory indices, for separate morphologic types, were
      established and thus the diagnostic opportunities were increased. The duration of
      the oligosymptomatic course is also different, the highest being in the
      endoproliferative type--an aveagre of 10 years and the shortest--in the
      membranaceous-proliferative type--an average of 3 and 4 months. In the patients
      studied, in spite of the lack of manifested clinical and laboratory activity, a
      definite tendency is found towards gradual disease course with restricted renal
      functional potentialities. Besides on glomerulonephritis morphological type, this
      tendency depends on some additional factors as intercurrent diseases, keeping of
      no optimal regimen of life and labour, pragnancy etc. The authors are provided
      grounds to admit that early complex diagnosis specifying is a necessity in
      carrying out systematic prophylactic and therapeutic measures, thus improving the
      disease prognosis.

PMID- 1014610
TI  - [Frequency and complications of cholelithiasis].
AB  - The authors studied a total of 16557 necropsy reports for 20 years, at the Chair
      of Pathologic Anatomy, Medical Faculty, Sofia, as regards the incidence and
      complications of cholelithiasis. In order to determine the effect of the applied
      modern antibiotic treatment, the material studied covers the decades 1932-1941
      and 1963-1972. Cholelithiasis incidence grew about five times during the second
      period. A change in the incidence of certain complications is also observed--a)
      there is a considerable decrease in the number of liver abscesses during the
      antibiotic period (about three times); b) the number of the developed biliary
      cirrhosis grew (about three times). With age aspect, the peak incidence has
      shifted with a decade backwards during the second period, life prolongation being
      the reason for it.

PMID- 1014611
TI  - [Treatment of obesity with a high-protein, high-fat, "carbohydrate-free" diet].
AB  - Sanatorium treatment for 27 days was carried out for 52 patients with obesity of
      alimentary metabolism type, consisting of moderate loading and high-protein, high
      lipid diet with 2430 to 2840 cal daily, with unusually low carbohydrate contents-
      10 g for the first week and 38 g--in the fourth. The authors established a
      favourable total and an average daily body weight loss of the patients,
      irrespectively of the relatively high caloric intake. No sense of hunger was
      reported from the majority of the patients. The subjective complaints observed
      are more frequent and more severe, as compared with the other treatment regimens
      with reducing but balanced dietetic regimens. The majority of the subjective
      complaints established could be associated with the objectively confirmed
      compensated metabolic ketoacidosis. The unfavourable changes in the followed-up
      laboratory indices are: considerable decrease of blood sugar, massive ketonuria,
      elevation of serum uric acid and deviations in the acid-base parameters. Serum
      lipid indices fell under the effect of the treatment and body weight reduction.
      What impresses is the serum cholesterol reduction in spite of the high exogenic
      import, the diminution of cholesterol-lecithin index and the marked elevation of
      free fatty acid in serum, manifestation of incresed lipolysis in the lipid
      depots. (he diet indicated is not balanced and not physiological. It must be
      applied casually in obesity treatment. Its application is possible only after a
      strict assessment of each individual patient with obesity with no accompanying
      diseases, that do not agree with the partial fasting and cannot be included in
      intensive motor regimen.

PMID- 1014612
TI  - [Thyroid suppression during and after thyrostatic treatment of thyrotoxicosis].

PMID- 1014613
TI  - [Therapeutic effect in 3 cases of hepatic coma in viral hepatitis].
AB  - The author reports his observation on three cases of coma hepaticum in viral
      hepatitis treated at the Internal Diseases Ward, Military Hospital, in the town
      of Asmara, Ethiopia. Parallelly with the usual hepatoprotective drugs and
      antibiotics, corticosteroids were administered as well as the preparation
      Reducdyn, containing homocysteine and cysteine-carriers of sulphhydryl groups.
      Complete restoration to health was achieved in two of the patients after three
      days in grave coma. The third patient was aroused from the comatose state for six
      hours but later had a lethal end on the eighth day post coma onset. According to
      the author, the combination of that preparation with corticosteroids is
      pathogenetically grounded and enables the administration of the latter in lower
      and safe doses. The author stresses upon the importance of early therapy in coma
      hepaticum.

PMID- 1014614
TI  - [Study of the interrelationship of glycemia-nonesterified fatty acids in physical
      activity in diabetics and patients with a normal glucose tolerance test].
AB  - Sixty four experiments were carried out in middle aged diabetics with normal and
      over-normal body weight and in a control group of patients with NGTT with a
      parallel follow-up of blood sugar and NEFA with an uptake of 50 g glucose per os
      and the performance of a moderately difficult physical loading (hiking) or
      complete rest in a bed for 2.5 hours. A better glucose utilization was found
      after physical loading in both groups of patients as compared with the rest
      period. Glucose utilization in patients with diabetes mellitus in physical
      loading is the same independently of the blood sugar initial level, providing
      grounds to admit that the betacyte formation apparatus is not strained. NEFA
      decrease by the 60th minute in diabetics, both in physical loading and at rest
      does not substantially differ from the subject with NGTT. That comes to show that
      NEFA utilization in that period is almost the same for the two groups. In
      patients with NGTT at the end of the physicalloading NEFA is sharply elevated
      over the initial level (lipolysis), while in diabetics, they remained at the
      level of the 60th minute.

PMID- 1014615
TI  - [Apex carotis diagram and benign systolic murmurs].
AB  - The apex-carotis diagram is a new mechanocardiographic, non invasive method
      consisting of integration of the carotidogram and apexcardiogram--synchronously
      recorded. The value of the amplitude height of these curves at every 0.025 sec
      are transferred to an orthogonal coordinate system and later the points connected
      in a chronological order thus obtaining the apex-carotidogram (ACD). ACD have
      been constructed in 62 healthy subjects and in 26 people with innocent systolic
      murmur, aged between 14--65 years. Our investigation showed no difference between
      the control group and the people with innocent murmur. The points of connection,
      lines, segments, fields and axis of ACD were the same in both groups. The angles
      alpha, beta, gamma, delta, epsilon measured quantity and calculated showed no
      statistical difference (p greater than 0.05).

PMID- 1014616
TI  - [Adrenaline test and the diagnosis of cancer of the large intestine].

PMID- 1014617
TI  - [3 cases of combined dissecting aortic aneurysm and medionecrosis].

PMID- 1014618
TI  - [Visceral form of sarcoidosis with a favorable effect from splenectomy].

PMID- 1014619
TI  - [Vegetative polypoid forms of stomach cancer with a cardial location (1 case)].
AB  - A case with vegetating polypoid gastric cancer in the cardio-esophageal zone is
      described. The cancer remained masked by the accompanying circulatory and septic
      complications manifested on the first place in the clinical diagnosis due to the
      lack of previous clinical symptoms of the digestive system. Attention is paid to
      the vegetating polypoid cancers of the cardio-esophageal zone, being with a vast
      dissemination, before manifesting a typical clinical symptomatology.

PMID- 1014620
TI  - [Bone metabolic disorders after prolonged treatment with antiepileptic agents in
      a patient with idiopathic hypoparathyroidism].
AB  - A case is reported of a patient, aged 20, with idiopathic hypoparathyroidism,
      manifested with the picture of epilepsy with a long treatment with antiepileptic
      remedies. Two years after the initiation of the antiepilertic treatment, severe
      skeleton disturbances occurred with manifested osteoporosis and multiple
      symmetric zones of bone reconstruction, hypocalcemia, hyperphosphatemia and
      elevated serum alkaline phosphatase. The disturbances of calcium and phosphorus
      level in blood are favourably affected by the application of relatively high
      vitamin D doses. The role of the long-term anticonvulsive treatment in the
      development of vitamin D resistant rickets and osteomalacia is discussed.

PMID- 1014621
TI  - [Megaloblastic anemia in a patient with epilepsy treated with anticonvulsants].

PMID- 1014622
TI  - [Value of the lymphocyte transformation test with phytohemagglutinin in rhematoid
      arthritis].
AB  - The aim of the present study was to determine the significance of the lymphocyte
      transformation test with phyto-hemagglutinin in connection with the degree of
      inflammatory activity and serological changes. Lymphocyte transformation test
      with phytohemagglutinin was performed on 46 of the patients with rheumatoid
      arthritis active stage, diagnosed according to the New York criteria. In patients
      with low and moderate inflammatory activity the lymphocyte transformation test
      has values close to those of the controls. In patients with high inflammatory
      activity either low values or considerably higher were established as compared
      with the control group. The values of the test were proved, through the
      statistical analysis, to be heterogenous quantities in seropositive and
      seronegative patients.

PMID- 1014623
TI  - [Serum complement level (C'H5O) during treatment of rheumatoid arthritis
      patients].
AB  - Decreased total complement serum level (C'H50) was established in 72 per cent of
      the 78 patients examined, associated most likely with the developing processes of
      antigen-antibody reaction and the severe course of the illness. The applied
      treatment with different antirheumatic remedies, according to their mechanism of
      action, determined the respective changes in the complement level. Indomethacinum
      and chinoline derivatives induce complement values elevation, whereas the
      corticosteroids, salicylate and pyrazolone preparations lead to the complement
      values normalization.

PMID- 1014624
TI  - [Ischemic heart disease--risk factors for agricultural and industrial workers and
      administrative personnel].

PMID- 1014625
TI  - [Desopimon in the treatment of obesity].
AB  - The authors tested the tolerance and therapeutic effect of desopimon preparation
      (1-p-chlorophenyl-2-aminopropane hydrochloride) in 44 subjects with obesity--I,
      II and III degree. They found a manifested appetite-inhibiting effect of the
      medicament in 41 of the patients and slight in two (the treatment was
      discontinued in a female, due to urticaria). Side effects, similar to those
      described with phenformin and phenmethrazin derivatives were not established.
      Body-weight loss is 12,9 kg per subject for a period of a month and a half, and
      the analysis of the data revealed that the weight loss was entirely on the
      account of the fatty tissue reduction. Triglyceride diminution was established in
      serum whereas free fatty acids were increased. After the confrontation of their
      own data those of some other researchers, the authors recommend desopimon as a
      suitable additive means in the treatment of simple nutritive (hyperphagic)
      obesity.

PMID- 1014626
TI  - [Several lipid indices in hypertension].
AB  - Forty four patients with arterial hypertension were examined. Thorough clinical
      examinations were carried out. Total lipids, total cholesterin and triglycerides
      in serum were determined at the laboratory. The lipid-acid composition of
      erythrocytes was studied by gas chromatography of the same patients. A control
      group of 10 healthy subjects were also examined. Hyperlipemia incidence among the
      patients amounts to 75 per cent. The ratio saturated (monoene and monoene) diene
      fatty acids was found to be increased in erythrocyte lipids of hypertonics. The
      deficiency of polyene fatty acids in erythrocytes was discussed to correlate to
      their deficiency in plasma. A relationship was established between the deficiency
      of polyene fatty acids in erythrocytes and the hyperlipemia present.

PMID- 1014627
TI  - [Social risk factors for rheumatoid arthritis (epidemiologic social-medical
      study)].
AB  - An epidemiological social-medical study was carried out in the section of IX
      polyclinic--Sofia, aiming at the establishment of the social risk factors effect
      upon the origination and course of the rheumatoid arthritis (RA), in view of the
      particularly social importance of the disease invalidity. The model is based on
      statistical methods for programmed computor processing. Two hundred and forty six
      subjects were examined, the basic group of 44 being with diagnosed RA according
      to the international criteria (0.35% from the population) and 2 control groups-
      patients with infectional alergic arthritis and healthy subjects. The assessment
      of the RA severity degree was performed according to the numeric method,
      elaborated for that purpose, based on the following criteria: number of the
      joints, kind of the joint involvement, functional capacity, patients' personal
      assessment of the difficulties due to the disease, disease duration, ESR,
      rheumatoid factor, X-ray changes according to the adopted four degrees. The
      following social factors were studied: occupation, kind of work, working
      conditions, financial status, education, home conditions, mode of life, activity
      in the leisure time. A statistically significant (correlation C with P less than
      0,05--0,001) unfavourable effect of the following complex of risk social factors
      was established: 1. RA risk factors--unfavourable microclimatic working (C=0,24)
      and home (C=0.30) conditions: 2. Risk factors for RA invalidity--occupations with
      heavy physical work (C=0,40), wol income (C=0,31) and unfavourable home
      conditions (C=0,22). The results obtained will serve as a ground for concrete
      directed rheumatoid arthritis prophylaxis. That outlines the perspectives of
      similar studies for assessment of the effect of life environmental factors upon
      human health state.

PMID- 1014628
TI  - [Acute renal insufficiency in poisoning with cistol (carbon tetrachloride)].
AB  - Three cases of acute intoxication with the preparation "Cistol", containing
      tetrachloro-methane were described, with the development of acute renal
      insufficiency, treated with hemodialysis. The attention of the physicians and the
      society is drawn to the risk of intoxication by that preparation. Early
      hemodialysis is recommended in case of such intoxications.

PMID- 1014629
TI  - [Left anterior hemiblock in a variant form of angina pectoris].
AB  - Certain peculiarities of the anterior left hemiblock in a variant of angina
      pectoris are dynamically followed up. The recorded anterior left hemiblock
      indicates a certain parallelism and succession and follows the rest of the ECG
      changes. The deviations of the cardiac axis in the left anterior hemiblock in the
      variant form of angina pectoris has a certain diagnostic and especially
      prognostic significance. The character of the hemiblock is determined by the
      topic position and phyoxia degree. The clinic of the hemiblock is determined by
      the basic ailment.

PMID- 1014630
TI  - [Dubin--Johnson syndrome].

PMID- 1014631
TI  - [Chronic recurrent pancreatitis with erosive gastritis in a patient with primary
      hyperparathyroidism].
AB  - A female with premary hyperparathyroidism and secondary renal lesions, as well as
      lesions of the stomach and pancreas is described. The initial illness was
      manifested by repeated renal crises. Later, gastroenterological complaints
      appeared--epigastralgia, vomiting, frequent hematemesis with melena. That was the
      cause for a gastric resection, diffuse erosive gastritis being found. After the
      operation, the pains and the vomiting of hematin matter repeatedly recidivated.
      Clinically and at the laboratory, data were formed for a chronic recidivating
      pancreatitis with the presence of primary hyperparathyroidism. The postoperative
      treatment of the parathyroid adenoma led to an improvement of the
      gastroenterological complaints.

PMID- 1014632
TI  - [2 cases of primary pulmonary hypertenstion].

PMID- 1014633
TI  - Cancer incidence in Jamaica. An 18-year analysis (1958--1975).

PMID- 1014634
TI  - Problems in interpreting electrocardiograms (ECG'S) AND QUESTIONNAIRES FOR EFFORT
      PAIN IN RURAL Jamaica.

PMID- 1014635
TI  - Antimicrobial resistance in organisms isolated at the University Hospital of the
      West Indies during 1975.

PMID- 1014636
TI  - A 3-year review of medico-legal autopsies performed at the Kingston Public
      Hospital, Jamaica (1973-1975).

PMID- 1014637
TI  - Total body water, extracellular and plasma volume compartments in sickle cell
      anemia.

PMID- 1014638
TI  - Nursery admission temperature in immature newborns--the effects of birth-arrival
      interval and asphyxia.

PMID- 1014639
TI  - [Complications following electric cardioversion in patients with acute myocardial
      infarct].

PMID- 1014640
TI  - [Aortic aneurysms in autopsy records].

PMID- 1014641
TI  - [Laboratory studies in the diagnosis of early missed abortion].

PMID- 1014642
TI  - [Biochemical and oligobiopsy studies of bones in liver cirrhosis].

PMID- 1014643
TI  - [Serum vitamin B-12 level in patients with pancreatitis].

PMID- 1014644
TI  - [Pregnancy, labor and puerperium in a case of Wolff-Parkinson-White syndrome and
      supraventricular tachycardia].

PMID- 1014645
TI  - [Complete disappearance of asthma following subphrenic vagotomy performed for
      peptic ulcer].

PMID- 1014646
TI  - [Nephrotic syndrome in secondary syphilis].

PMID- 1014647
TI  - [Some aspects of treating aplastic anemia with blood].

PMID- 1014648
TI  - [Case of thrompopenia of allergic etiology].

PMID- 1014649
TI  - [Hyperosmotic nonketotic diabetic coma].

PMID- 1014650
TI  - [Case of transient general amnesia].

PMID- 1014651
TI  - [Abortive form of Melkersson-Rosenthal syndrome].

PMID- 1014652
TI  - [Chondrodysplasia punctata in a 13-year-old child].

PMID- 1014653
TI  - [Unusually estensive endometriosis in perineal scar].

PMID- 1014654
TI  - [Prognostic importance of gallop rhythm in patients with myocardial infarct].

PMID- 1014655
TI  - [Clinical aspects of pericarditis].

PMID- 1014656
TI  - [Lymphocytic meningoencephalits].

PMID- 1014657
TI  - [Modern evaluation of eye fundus in diabetes].

PMID- 1014658
TI  - [2 forms of fibrous changes found in the locomotor system].

PMID- 1014659
TI  - [Case of rare lung neoplasm].

PMID- 1014660
TI  - [Recurrent electrocardiographic syndrome after paroxysmal tachycardia].

PMID- 1014661
TI  - [Disseminated intravascular coagulation syndrome and microangiopathic hemolytic
      anemia in generalized gastric carcinoma].

PMID- 1014662
TI  - [3 cases of nystagmus alternans].

PMID- 1014664
TI  - Protozoa as the regulators of pest insects populations.

PMID- 1014663
TI  - The study of regulation systems in parasite populations as a basis for using
      biological methods of control.

PMID- 1014665
TI  - The influence of nematodes and parasitic fungi on host insects.

PMID- 1014666
TI  - The system host-parasite as an ecological homeostate.

PMID- 1014667
TI  - The role of the taxonomist in biological parasitology.

PMID- 1014668
TI  - The question of diseases caused by Echinococcus granulosus and Alveococcus
      multilocularis on the Taimyr Peninsula.

PMID- 1014669
TI  - Investigations into the biocenosis of small mammals' nests.

PMID- 1014670
TI  - Microbiocenosis of Clethrionomys glareolus nests in the East and West
      Carpathians.

PMID- 1014671
TI  - Host-parasite relations between Oligochaeta and helminths.

PMID- 1014672
TI  - The interdependence of parasites in parasitocenoses of the intestine of animals.

PMID- 1014673
TI  - The influence of chemical contamination of the natural environment on the
      parasitological organisms.

PMID- 1014674
TI  - The influence of pollution of Bulgarian section of the river Danube on the
      occurrence of helminthiases in fish.

PMID- 1014675
TI  - The influence of industrial pollution on the nematodofauna of plants and soil in
      the region of smelting works "Kremikovci".

PMID- 1014676
TI  - The influence of thermic pollution on parasitocenoses structure in water
      reservoirs.

PMID- 1014678
TI  - The properties of formation of the trematode fauna in molluscs in water
      reservoirs of the river Dnieper cascades.

PMID- 1014677
TI  - The influence of training the river Dnieper, construction of water stops and
      hydroelectric plants on the parasitofauna in fish.

PMID- 1014679
TI  - The effect of thermic pollution of waters on the distribution of pathogenic
      Naegleria strains.

PMID- 1014680
TI  - Some ecological-parasitological aspects of large-scale animal production.

PMID- 1014681
TI  - Ecological properties of helminth fauna in water reservoirs on dairy farms in
      Lithuanian SSR.

PMID- 1014682
TI  - Swimmers' itch and waterfowl management.

PMID- 1014683
TI  - Human activity as a factor in the distribution of ectoparasites and vectors of
      man and animal diseases.

PMID- 1014684
TI  - The anthropophilism rate in mosquito Culex pipiens pipiens L., 1758 (Diptera,
      Culicidae) in the area of human settlements on the Gdansk coast.

PMID- 1014685
TI  - Helminthological problems in guest workers--is there any danger in distribution
      of helminthic disease?

PMID- 1014686
TI  - Transmission of Taenia saginata in rural areas.

PMID- 1014687
TI  - Helminthological and microbiological analyses of municipal waste of the city of
      Lodz as the criteria for the evaluation of the rate of environmental pollution.

PMID- 1014688
TI  - Natural foci of diseases in the environment exploited or artificially formed by
      man.

PMID- 1014689
TI  - Strongyloides stercoralis in Eastern and South-Eastern Poland.

PMID- 1014690
TI  - The role of wild mammals of Central Asia as man's and domestic animals' helminth
      reservoirs.

PMID- 1014691
TI  - Parasitological endangering of environment in the aspect of increasing tourist
      recreation traffic.

PMID- 1014692
TI  - Ecological properties of poly-host helminths (on the example of Diphyllobothrium
      genus).

PMID- 1014693
TI  - Various types of forest hunting grounds as the habitat of interinfection with
      helminths of wild and domestic animals.

PMID- 1014694
TI  - Ecological problems in fish parasitology.

PMID- 1014695
TI  - Variations in pathogenicity of parasites due to man's interference. Introduction
      to the discussion.

PMID- 1014696
TI  - Variability of man as the host of a parasite.

PMID- 1014697
TI  - Formation of new host-parasite systems on the example of nematodes genus
      Neoaplectana.

PMID- 1014698
TI  - Ecological differentiation between the regulating and devastating parasitic
      structure.

PMID- 1014699
TI  - The role of information services in environmental parasitology.

PMID- 1014700
TI  - [Mathematical models in biology: their use and limitations].

PMID- 1014702
TI  - [Quantitative method of description of some population phenomena in
      parasitology].

PMID- 1014701
TI  - [Statistical methods in the description of parasite morphology].

PMID- 1014703
TI  - [Planning of experimental designs].

PMID- 1014704
TI  - [Methods of analysis of the host-parasite system dynamics].

PMID- 1014705
TI  - [Mathematical methods in parasitology].

PMID- 1014706
TI  - [Subacute encephalitis during lactation (author's transl)].
AB  - Two cases of encephalitis during lactation are reported. The illness started with
      psychotic symptoms and some weeks later neurological disturbances appeared. The
      course of the illness was subacute and both cases the brain scan was abnormal
      with numerous nodules. A CSF proteinogram showed an acute phase reaction,
      pointing to an organic lesion of the nervous system, but no impairment of the
      blood CSF barrier and normal immunoglobulin G levels. The possible aetiological
      factors, as well as the CSF and brain scan findings are discussed.

PMID- 1014707
TI  - [Cerebellar ataxia in three generations with apparently dominant inheritance
      (author's transl)].
AB  - The clinical features and genetic inheritance of cerebellar ataxia, presumably of
      the Holmer type, are described in a family with four affected members over three
      generations. Two of these cases were severly affected, whilst the remaining two
      cases were probably of a relatively mild form. The pitfalls in diagnosis are
      discussed and the dangers of incorrect diagnosis pointed out.

PMID- 1014708
TI  - [Cerebral arachnoid cysts in children with local bulging of the skull (author's
      transl)].
AB  - A series is reported of 9 cases of supratentorial arachnoid cysts in children
      under the age of 14 years. The predominant clinical and radiological sign is
      local bulging of the skull, caused by the underlying cyst. The characteristic
      angiographic findings and anomalies in the phlebogram are discussed. Operative
      measures (trephination and ventriculo-auricular shunt) aim at restoration of the
      disturbed cerebrospinal fluid circulation and resection of the wall of the cyst.
      Selection of patients for operative measures and results of treatment are
      discussed.

PMID- 1014709
TI  - [Treatment of forced weeping (author's transl)].
AB  - A derivate of gamma-aminobutyric acid was found to have a favourable therapeutic
      effect in patients with forced weeping (weeping sickness). All 10 treated cases
      were shown to have motor neuron lesions resulting from other cerebral changer
      (cerebrovascular accident, brain atrophy, diffuse vascular changes).

PMID- 1014710
TI  - [Motor nerve conduction velocity in uraemic polyneuropathy: correlation with
      metabolic factors (author's transl)].
AB  - The following parameters have been examined in twenty-one patients suffering from
      chronic renal failure (creatinine level between 4.5 and 18.8 mg/100 ml serum):
      maximum motor nerve conduction of the peroneal nerve, amplitude of the compound
      muscle action potential of the extensor digitorum brevis muscle, serum creatiine,
      total protein, serum globulins, serum albumins, alkali reserve, time of increase
      of serum creatinine above 4 mg/100 ml up to time of determination of the maximum
      motor nerve conduction, daily urinary excretion, mean blood pressure, (p less
      than 0.01) was found between maximum motor nerve conduction, as well as amplitude
      of the compound muscle action potential, and the serum albumin level only.
      Decreased levels of serum albumin, is correlated with diminished nerve conduction
      and a lower amplitude. The relationship between the electrophysiological data and
      serum albumin levels maybe explained on the basis of progression of a pre
      existing polyneuropathy due to additional dietary malnutrition. A different
      interpretation is the assumption of an inactivation of neurotoxin on binding by
      albumins. A decrease in the albumin level would, therefore, result in an
      increased amount of unbound toxic agent. The values of the maximum motor nerve
      conduction were between 16 m/sec and 51 m/sec (mean value 42.2 m/sec), pointing
      to a polyneuropathy of primary axonal type rather that to primary
      demyelinization. The amplitudes of the compound muscle action potentials were not
      greatly reduced and thus the uraemic polyneuropathy seems to be of mixed type. In
      uraemic polyneuropathy different aetiological factors have to assumed. According
      to the prevalent factor a polyneuropathy of predominantly axonal or predominantly
      demyelinizing type may result.

PMID- 1014711
TI  - [Rectal electrical potential difference and plasma aldosterone in
      hyperaldosteronism and low-, normal- and high-renin hypertension].
AB  - Rectal electrical potential difference (P.D.), plasma aldosterone and plasma
      renin activity were measured in 25 normal subjects, 80 patients with untreated
      essential hypertension, 4 patients with primary and 9 patients with secondary
      hyperaldosteronism. In normal subjects the rectal P.D. was 26 +/- 10 mV (+/-
      S.D.); in patients with hyperaldosteronism it was 51 +/- 7 mV. Plasma aldosterone
      and rectal P.D. were correlated significantly (r = 0.84, p less than 0.001) in
      these two groups combined. In 29% of patients with low-renin hypertension, in 9%
      of patients with normal-renin hypertension and in 3 out of 8 patients with high
      renin hypertension, rectal P.D. was found to be elevated in the presence of
      normal plasma and urinary aldosterone and no correlation was observed between
      plasma aldosterone and rectal P.D. (r = --0.09, n.s.). In 3 out of 7 patients
      with low-renin hypertension and high rectal P.D., plasma and urinary aldosterone
      were consistently suppressed. Since patients with low renin and high rectal P.D.
      responded favourably to spironolactone therapy it is suggested that
      mineralocorticoids other than aldosterone may contribute to the pathogenesis of
      the hypertension in these cases. The aetiology of raised rectal P.D. in normal
      and high-renin hypertension is not clear, but both catecholamines and angiotensin
      II may be involved. The measurement of rectal P.D. alone is of limited value as a
      screening test for primary hyperaldosteronism in hypertensive patients, but
      combined with renin measurements it is a valuable tool for further investigation
      of patients with suspected mineralocorticoid excess syndromes, as well as for
      adjusting therapy with competitive aldosterone antagonists in patients with
      proven primary or secondary hyperaldosteronism.

PMID- 1014712
TI  - [World trends in infant mortality since 1950].
AB  - Despite the considerable progress made in recent decades, and perhaps even partly
      because of the very uneven distribution of this progress, infant mortality is
      still very high in some regions, whereas in other regions it is tending, if not
      disappear completely, at least to become numerically negligible even though
      remaining a matter of social concern. Whereas in tropical Africa almost one child
      in five dies before its first birthday, in Japan or Scandinavia it is one child
      in a hundred. Infant mortality rate varies between these two extremes, but there
      is a substantial gulf between  the "most developed" regions which are all below
      30% and the "least developed" regions which fall into three categories: 65-100%
      (Latin America, Eastern Asia except Japan), around 140% (Northern Africa, South
      Asia, Melanesia), and about 200% (topical Africa). These inequalities between
      countries overlap with inequalities between social groupings by urbanization,
      social/occupational level, education and income, are all variables that are
      correlated with infant mortality to a greater or lesser degree. The pace of the
      progress achieved since 1950 seems to be independent of the starting level.
      Contrary to the development of mortality at other ages, it is not in the
      countries with high mortality that infant mortality has decreased most. The pace
      of reduction divides the most developed regions into three distinct groups: very
      rapid reduction (Japan), rapid reduction (Scandinavia, Western Europe, Southern
      Europe and Eastern Europe), and slower reduction (British Isles, Northern America
      and Australia/New Zealand). Thus Japan rapidly caught up with Western Europe and
      the English-speaking countries and has now reached the same level as Scandinavia.
      On the other hand, the English-speaking countries have fallen behind the
      Scandinavian countries and are now at par with Western Europe. The reduction of
      infant mortality mainly concerned deaths of children over one month of age or
      even over one week of age and otherwise is due to reduction of infectious
      diseases. Consequently, in the most developed regions mortality is highly
      concentrated in the first week of life and is mainly attributable to the "causes
      of perinatal mortality" and the "congenital" anomalies". In the least developed
      regions, on the other hand, the infectious or parasitic diseases are still of
      decisive importance and the risk of death remains very high throughout the first
      year of life and even beyond. The risk may be even higher during the second year,
      when weaning takes place abruptly and results in serious difficulties in feeding.

PMID- 1014713
TI  - [World health-related indicators].
AB  - Many of the statistics given in this report are estimates based on tentative data
      and on that extent are not reliable in a strict sense. But the picture they
      present of gross differences in demographic and social characteristics, in vital
      statistics, and in resources of medical manpower and hospital beds between major
      areas of the world is real. More than half of the people of the world live in
      South Asia and East Asia; population density is highest in Western Europe; and
      highest rates of population growth are in Middle America and Tropical South
      America. In Europe less than one-third of the population are aged under 20 years,
      whereas more than half the population are aged under 20 im Middle and Tropical
      South America and the Carribbean, in Africa and in South Asia. Urbanization is
      high in Temperate South America, Northern America, Northern and Western Europe,
      and Oceania. The daily dietary energy supply per person is 50% higher in Northern
      America, Europe, USSR, and Ocenia than in Africa (excluding Southern Africa,
      South and East Asia. The Gross National Product in Northern America is 10 times
      higher than in Tropical South America and 30 to 40 times higher than in Western
      Middle and Eastern Africa and in Middle South and South East Asia. Crude birth
      rates are close to three times higher in Africa, Middle America and South Asia
      than in Europe, North America and USSR. Differences in crude death rates are less
      -rates in Western, Middle and Eastern Africa are double these of America Europe,
      USSR and Oceania. The Expectation of Life is over 70 years for Northern America,
      Europe, USSR and Oceania. It is under 50 years for Western, Middle and Eastern
      Africa. In all areas the expectation of life at birth has increased--by up to 10
      years--in the past quarter century. Infant mortality is less than 20 per 1 000 in
      Northern and Western Europe and Northern America. It is over 100 in Africa and
      South Asia. Number of physicians range from 25 per 10 000 population in USSR to
      less than 1 per 10 000 in Western, Middle and Eastern Africa. There are over 100
      hospital beds per 10 000 population in USSR and in Northern and Western Europe,
      less than 10 per 10 000 in Western Africa, Middle South Asia and South East Asia.

PMID- 1014714
TI  - [Epidemiology of venous diseases at old age (author's transl)].
AB  - Venous diseases are of interest to gerontology because 1. the morbidity in
      connection with venous diseases in both men and women increases almost linearly
      with age 2. more complications, some of them fatal, must be anticipated and 3. a
      greater percentage of secondary and primary diseases are recorded than in younger
      people, which must always be included in therapeutic planning.

PMID- 1014715
TI  - [On the morphology of venous diseases in ageing (author's transl)].
AB  - The author discusses age-connected changes in vein walls and problems of
      phlebosclerosis, varces and of the post-thrombotic syndrome from the
      morphological point of view.

PMID- 1014716
TI  - [The diagnostics of venous diseases (author's transl)].

PMID- 1014717
TI  - [The significance of phlebography for diagnosing venous diseases (author's
      transl)].

PMID- 1014718
TI  - [Problems of coagulation analysis in diagnosing inflammatory and thrombotic
      venous diseases in ageing (author's transl)].
AB  - Diagnosing inflammatory and thrombotic venous diseases by analysing coagulation
      is difficult because the results obtained with this method are not certain. Not
      all persons concerned use scintigraphy, the ultrasonic methods, infrared
      photography and phlebography as routine diagnostic methods. The surest way of
      diagnosing inflammatory and thrombotic venous diseases is still to bear in mind
      the limitations and the criteria mentioned and to combine the clinical and
      paraclinical methods into a diagnostic mosaic.

PMID- 1014719
TI  - [Outpatient treatment of thrombophlebitic and thrombotic conditions in ageing
      (author's transl)].

PMID- 1014720
TI  - [Systematic medical observation and care of aged people suffering from diseases
      of the veins (author's transl)].

PMID- 1014721
TI  - [Thrombolytic treatment of deep leg vein thrombosis in ageing (author's transl)].

PMID- 1014722
TI  - [Obliteration therapy of varicosis (author's transl)].
AB  - In introduction is given into the etiology and pathogenesis of varicosis. The
      causal therapy of varicosis, obliteration therapy, indication and
      counterindications, advantages and disadvantages of this method, the choice of an
      optimum obliterating agent and side effects are discussed.

PMID- 1014723
TI  - [Surgical treatment of acute deep thrombophlebitis (author's transl)].
AB  - Preoperative, operative and post-operative measures used in connection with deep
      phlebothrombosis by the Angiological Centre of the "Heinrich Braun" Country
      Hospital, Zwickau, are described. The clinical, phlebographic and
      phlebodynamometric results following thrombectomy are reviewed.

PMID- 1014724
TI  - [Surgical therapy of post-thrombotic conditions (author's transl)].
AB  - The author begins with a brief discussion of the terminology of phlebitis and
      then elucidated the significance of the deep veins and of the secondary varices
      in connection with the post-thrombotic syndroms. He explains why it is not
      possible to take therapeutic measures direct at the blocked vein section and goes
      into bypass operations in the case of isolated pelvic vein and formal vein
      blockade as a possible method of treatment. He stresses the importance of early
      treatment.

PMID- 1014725
TI  - [Prevention of venous diseases from nutritional-physiological aspect (author's
      transl)].
AB  - Definite correlations between venous diseases and disturbances of nutrition have
      heretofore been known to exist in the case of overweight only. Obese persons
      generally show a marked tendency to develop phlebothromboses, whereas it has not
      so far been possible to accurately define correlations with varicosis.
      Obstipations due to improper forms of nutrition may be considered to be another
      noxa causing venous disorders. On the basis of latest results of research
      discussed in this paper, recommendations are made for proper forms of nutrition
      for the prevention and therapy of venous diseases.

PMID- 1014726
TI  - [Ageing changes in collagen -- in vitro ageing changes in collagen (part III)
      (author's transl)].
AB  - In the present three parts of the survey ageing-changes in collagen physical and
      chemical qualities are discussed at first. Further a summary on questions of the
      biosynthesis of collagen, changes of the metabolism in the ageing organism and
      changes of the ripening collagen in the living organism is given. Following in
      vitro-ageing-changes of collagen and causes of the changes of the ageing organism
      are described. A summarizing appreciation of the ageing-changes in the collagen
      finishes the survey.

PMID- 1014727
TI  - [Endocrine diseases in the age (author's transl)].

PMID- 1014728
TI  - [Industrial hygienic complex examinations of places of employment of elderly
      workers in telecommunication technics].
AB  - Authors examinated conditions on 76 places of employment of elderly women by
      means of a screening methode, an estimated findings in comparison to design
      standards under consideration of special aspects of aged workers. In regard of
      work organization, physic strain, demands to sense organs and the exposition of
      environment factors conditions were acceptable. Imperfections in plase
      dimensions, lighing and laps organization induced 139 detailled straffs.
      Directions of the examinated enterprise till now many things improved in
      conformity with this study.

PMID- 1014729
TI  - Functional capability of 68-year-old people in the town of Jyvaskyla.
AB  - A cross-sectional study on the functional capability of 68-year-old persons was
      performed in 1973 in the town of Jyvaskyla in Central Finland. The mean values of
      the measured variables for men and women, respectively, were the following: vital
      capacity 1.7 l/m2 and 1.2 l/m2; threshold of auditory perception (4000 cps) 49.0
      dB and 28.4 dB, digit symbol 23.9 and 24.3 digits; digit span 9.5 and 9.7
      numbers; simple reaction time 0.27 sec; pred. max VO2 26.6 and 21.6 ml/kg - min.
      Persons with high physical working capacity or good self-assessed health attained
      better results compared to persons with low PWC or poor self-assessed health.

PMID- 1014730
TI  - [Age dependence of visual acuity after incomplicated cataractoperation (author's
      transl)].
AB  - The results of visual acuity in 1523 cataract-extractions were evaluated;
      comparing the visual acuity of the 7th to the 9th postoperative days, when the
      patients left the hospital. 73,1% of the patients had a supplemental disease of
      the eye or another general disease. 76,6% of the patients had a postoperative
      visual acuity between 5/4 and 5/15, clearly depending on the age of the patients.
      General diseases influence scarcely surgery, but the older the patients the more
      we find a reduced visual acuity that is reduced by generative senile macula
      disease. On an average they stayed in hospital for 9,4 days.

PMID- 1014731
TI  - [Influence of cytosolic fraction on incorporation of aminoacids into microsomal
      system of rat liver (author's transl)].
AB  - 1. Incorporation of 14C-leucine into a microsomal system from rat liver is
      decreased on old animals. 2. The decrease in 14C-leucine incorporation is not
      attributable to changes of the stability of the incorporation systems. 3. The
      decreased rate of incorporation from old animals is dependent from the cytosolic
      fraction.

PMID- 1014732
TI  - [The influence of age on healing of wounds in men and animals (author's transl)].
AB  - There is reported on experimental results (in people and animals) with regard to
      the course of the healing of wound. Factors influencing the healing of wound
      characterized by own results.

PMID- 1014733
TI  - [Experiences from a function as consultant of geriatrics in a district schwerin
      (author's transl)].
AB  - Consultant of geriatric, district. There is given an organizational model in
      complex care of the elderly in the district of Schwerin. The continuous care of
      the elderly, adequate to their requirements, wishes, problems, and difficulties
      by complex measures is an important part for the realization of the social
      political tasks of the SED and government. Especially in the district of Schwerin
      there are a lot of initiatives and already good results of effects in principle. 
      For the further improvement of the medical and social care for the aged is based
      in a foundation of a special working groups of general practioners in the
      district of Schwerin which coordinates all activities in this field. In this
      working group and its activities participate all local geriatrics
      (Kreisfachberater fur Geriatrie) under the chiefment of the district consultant
      of geriatrics.

PMID- 1014734
TI  - [Geriatric care commitee (author's transl)].
AB  - The medical and social care of the aged is a substantial task of General
      Practitioners in the GDR Public Health. Increasing consideration must be given to
      the individual social situation. According to Public Health directives covering
      all sectors of geriatric care we built a "geriatric care Commitee" whose members
      are a G.P., a geriatric welfare worker, the district nurses, a representative of
      the local plant health organisation and one of the elected munifipal council
      members. Tasks are described and achieved results are related. Significance of
      purposely coordination of all sectors participating in care for the aged is
      stressed.

PMID- 1014735
TI  - Carbohydrate metabolism of the lens depending on age.
AB  - Interpretation of factor analysis of 18 metabolic parameters of the bovine lens
      leads to the determination of the following criteria of lens metabolism: Factor
      1: Biologic aging of the lens 33.9%; Factor 2: Glycolysis regulation 17.7%;
      Factor 3: Topography of lens metabolism 8.7%; Factor 4: Regulation of fructose
      breakdown 7.9%; Factor 5: Substrate depot 6.6%; Factor 6: Kinases 6.3%. These
      results could partly be experimentally verified. This interpretation of factor
      analysis has been an attempt to fit biochemical processes to formal statistical
      parameters. There was no indication that any of the variables under investigation
      were indendently responsible for the age dependend changes. However, the set-up
      made evident that rather complex biochemical influences of different intensity
      bring about the observed aging phenomena. It may be assumed that on or the other
      of these variables acts as a "triggering mechanism". Age related disturbances in
      the biochemical balance may be initiated by the glycolysis regulation factor, the
      importance of which is expressed by its high portion of 17%. Here changes in the
      ratio of reduced and oxydized coenzymes may act as a "triggering mechanism" (26,
      30). Topography of lens metabolism, carbohydrate breakdown via metabolic
      pathways, the presence of substrate depots, and the internal regulation of the
      kinases are, according to their portion in factor loading, of about equal
      importance with respect to aging processes, however, factors 1 and 2, with a 50%
      portion, must be given precedence in any consideration. Factor 1, interpreted as
      "biological lens aging", yields about 1/3 of the information on the age influence
      on lens metabolism. This factor stands independent in being loaded by lens
      weight, which is the accepted age representative. However, lens weight means
      protein as well as the process of protein synthesis. It may be assumed that this
      factor represents a connective link between protein and carbohydrate metabolism,
      since it is well known that changes in protein belong to the most remarkable age
      disturbances (31,32), and that the quality of the proteins is dependent on the
      period of its synthesis (18,33).

PMID- 1014736
TI  - [The ageing-factors of several physical functions in man (author's transl)].
AB  - The ageing-factor is a measure for the rate of ageing. In the model of vitality
      the error rate mu corresponds to the ageing-factor. The ageing-factors of several
      physical functions can be determined from the ascent of decrease of these
      functions. The standardized ageing-factors of the considered physical functions
      range from 0,001 to 0,017 year-1 and are smaller than the ageing-factor of the
      whole organism. The date of the occurrence of pathological manifestations as a
      result of ageing-conditioned decrease of functions can be estimated by means of
      the ageing-factors.

PMID- 1014737
TI  - [Y-chromatin frequency, age (author's transl)].
AB  - Frequency of the fluorescent Y-chromatin bodies in the white blood elements of
      aged men was found to be significantly lower than that of young men (aged: N=35,
      mean frequency 68,78%; young: N=47, mean frequency 75,96%). This finding
      indicates that in the progressed age, the Y-chromosome tends to get lost from the
      cell, probably as a consequence of generalized functional im pairment of aged
      cell.

PMID- 1014738
TI  - [Thromboses and haemorrhages in geriatrics (author's transl)].
AB  - In elderly patients thromboses are especially important because of their
      frequency and consequences (invalidity) often demanding measures of
      rehabilitation. In thrombophilia there are prophylactic measures necessary
      founding upon new perceptions on pathogenesis (vascular wall factors; rheologic
      and microcirculatory factors and factors of hemostasis: increasing of factor
      VIII; decreasing of antithrombin III; hypofibrinolysis; increased aggregation of
      thrombocytes). In prophylaxis you should influence the predisposing factors
      (hypertension, diabetes, arteriosclerosis, adipositas), use dietetic and hygienic
      measures and also from the pharmalogical point medicines with complex effect,
      which not only act on one factor (blood coagulation) like the anticoagulants, but
      also on other pre-disposing factors; and at the same time activate the
      fibrinolysis and stop the aggregation of thrombocytes. Thrombolytica should be
      used in elderly patients with precaution. In hemorrhages in the age especially
      capillary protecting medicaments should be used to correct the increased
      fragility of capillaries. Of there is at the some time a arteriosclerosis,
      hypertension, diabetes mellitus, obesity.

PMID- 1014739
TI  - [Diabetes mellitus and femoral fractures in close proximity to the hip joint in
      multimorbid patients of old age (author's transl)].
AB  - From a great number of patients with femoral fractures in close proximity to the
      hip joint with an average age of 78.3 years, all diabetics were compared to
      persons with a normal metabolism in terms of concomitant diseases, causes of
      death, complications, and fracture healing. Although no differences with regard
      to fracture healing and subsequent functional results in later years could be
      established in patient put on the correct diet and insulin dose, as compared to
      the control group, the clinical complication rate and the mortality rate were
      significantly higher among patients of old age with Diabetes mellitus. To bring
      about a possible change, operating techniques providing the possibility of an
      early mobilisation and optimal physiotherapeutical after--care are recommended.

PMID- 1014740
TI  - [On the problem of so-called ulcer in the old age (author's transl)].
AB  - By our own experiences with 471 stomach resections (gastric ulcers) we have
      found, that the so-called special situation of ulcer in the old age--from Spang
      firstly defined--has to be critically discussed. There are three groups of
      patients: 1. Patients with the so-called old age ulcer. 2. Patients who got their
      ulcer in early years of life. 3. Patients who are younger than 50 years. We mean
      there is no existance of a special course of this disease in elderly patients.
      Only the rate of complications which was most frequently to be found in the first
      group, differs from the other patients. For the surgeons ulcer operations have
      the same general problems as to be found in operations due to other reasons by
      elderly and old patients.

PMID- 1014741
TI  - [Surgical treatment of benign thyroid diseases].

PMID- 1014742
TI  - [Course observations in children with hydrocephalus and myelodysplasia].

PMID- 1014743
TI  - [Surgical treatment of acute pelvic and leg thrombophlebitis].

PMID- 1014744
TI  - [Primary vesicorenal reflux in the adult age].

PMID- 1014745
TI  - [A case of injury due to metal-fragment in the neck with detachment of the
      trachea in the upper part of the tracheal bifurcation].

PMID- 1014746
TI  - [Explorative laparotomy and splenectomy in lymphogranulomatosis (surgical
      aspects)].

PMID- 1014747
TI  - [Various important subject relationships between phoniatry and psychology, as
      demonstrated on children's speech- and intelligence disorders].

PMID- 1014748
TI  - [Tasks and performance of surgical dispensary consultation hours for patients
      with benign upper abdominal diseases].

PMID- 1014749
TI  - [Extensive rupture of the liver and complications].

PMID- 1014750
TI  - [Consultation hour activity of the specialist for general medicine].

PMID- 1014751
TI  - [Bronchopulmonary Candida mycoses].

PMID- 1014752
TI  - [Clinical picture of Raynaud's disease].

PMID- 1014753
TI  - [Clinical and autopsy demonstration of recurrent myocardial infarct].

PMID- 1014754
TI  - [Psychological inquiries in patients after laryngectomy in comparison with normal
      persons and teachers with hearing disorders].

PMID- 1014755
TI  - [Tasks of the preliminary diagnosis within the frame of laboratory diagnosis in
      the current 5-year plan period].

PMID- 1014756
TI  - [Rehabilitation of patients with myocardial infarct in the German Democratic
      Republic. Current status and further development].

PMID- 1014757
TI  - [New studies on the incidence of typical surgical interventions and anesthetic
      procedures in a large territory].

PMID- 1014758
TI  - [The family physician and his patient--basic comments].

PMID- 1014759
TI  - [Communication between the physician and patient].

PMID- 1014760
TI  - [Utilization of medical care and physician-patient relations].

PMID- 1014762
TI  - [Health education in the general practice].

PMID- 1014761
TI  - [Social needs of the patient].

PMID- 1014763
TI  - [Consultation activity of the specialist for general medicine. Concept and
      results of an empirical analysis. 4].

PMID- 1014765
TI  - [Psychophysiologic correlates of "emotional lability"].

PMID- 1014764
TI  - [Factor analysis interpretation of the HAWIK of dyslexics].

PMID- 1014766
TI  - [Information processing and individual differences].

PMID- 1014767
TI  - [Selective processes in stimulus perception and psychophysiologic activation].

PMID- 1014768
TI  - [Combined gastroduodenoscopy and suction biopsy of the small intestine].
AB  - We are reporting on a simple method for performing gastro-duodenoscopy and biopsy
      of the small intestine on one course of examination. The biopsy probe for the
      small intestine carries a looped thread located behind the biopsy cartridge. This
      loop is grabbed by the biopsy forceps of the gastroduodenoscope. After both
      instruments have been inserted simultaneously, the biopsy probe may be pushed
      through the pylorous visibly and without any effort. This is followed by the
      gastro-bulbuscopy, if necessary with biopsy, and thereupon followed by the biopsy
      of the small intestine. To date we have examined 15 patients using this method.
      The examination was delayed in 2 patients only who had a markedly scarred bulb.
      We consider this method suitable for routine diagnostics since time is saved for
      both the examiner and the patient, since a two-fold insertion of instruments may
      be avoided, since the exposure to radiation is reduced, and since it is possible
      to obtain complete endoscopic findings with biopsy.

PMID- 1014769
TI  - [Therapy of abdominal complaints suspected to be of biliary origin].
AB  - In 37 patients suffering from functional disorders of the bile duct, a
      multicenter collective blind study was carried out with Hyoscine-N-butyl-bromide
      (HBB) sugar-coated tablets (5 X 20 mg/daily), and compared with a placebo in a
      randomized sequence. A statistically significant therapeutic effect with HBB was
      confirmed on the second day of treatment both by patients and physicians. The
      duration of treatment seems to be an important parameter as far as the action of
      HBB is concerned. No atropine-like side effects occurred.

PMID- 1014770
TI  - [Retroperitoneal lymphangiodysplasia with exudative enteropathy. A case of cystic
      dilated cisterna chyli and splenic cysts].
AB  - In a 16 years old girl we found the syndrome of exsudative enteropathy with
      intestinal lymphangiectasy which differs from previous reported cases by several
      malformations of the lymphatic system. Besides changes in the intestinal
      lymphatics there was a retroperitoneal lymphangiodysplasia, a reduction and
      hypoplasia of the lymph vessels in the legs and cysts in the spleen. By
      substitution of albumin followed by a diet with middle chained triglycerids
      (MCT), serum protein was stablised but a relapse could not be prevented. Surgical
      treatment was not possible because the changes were too extensive. The value of
      diagnostic measures for differential diagnosis of the intestinal lymphangiectasy
      is presented.

PMID- 1014771
TI  - [Electron miscoscopy studies of liver tissue in patients with amanita phalloides
      poisoning].
AB  - Electron microscopic findings of the liver are being described found in 4
      patients aged from 12 months to 26 years after poisoning with Amanita phalloides.
      Marked alterations were seen in nuclei, in the endoplasmic reticulum, and in
      mitochondria. Morphologic criteria of cholestasis were observed in one patient.
      Extreme cellular edema was found in two patients. Since our findings differ
      considerably in several points from those patients with Amanita phalloides
      poisoning previously reported, one may suppose, that e.g. age, sex, preexisting
      damage and liver function might be highly important for the extent and form of
      resulting liver damage.

PMID- 1014772
TI  - [Electron microscopy picture of oxyphenisatin-induced liver damage].
AB  - Ultrastructural investigations of liver biopsies are performed in 20 cases after
      phenolisatin reexposition and corresponding reactions of the laboratory findings.
      Alterations of the nucleus (segregation of nucleolus, condensation of chromatin)
      and of the rough endoplasmatic reticulum ("disarrangement", fragmentation and
      loss of ribosomes) were evident in all cases. In contrast, changes of the
      mitochondria (swelling) in various extent could only be observed in some cases.
      Besides that, frequently lipid includings and occasionally includings like
      lysosomal residual bodies are to be seen. Thus, as a hypothesis we suggest the
      nucleus resp. nucleolus to be one site of aggression of phenolisatin containing
      drugs. Findings already described by light microscopy such as reactions of the v.
      KUPFER cells and proliferations of the ductuli as well as cell proliferations in
      the portal fields are documentated by electronmicroscopy, too.

PMID- 1014773
TI  - [Transport of neonates (author's transl)].
AB  - All necessary organizational, technical and medical requirements for setting up a
      transport system for newborns were complied. Organizational and technical
      compatibility with existing emergency systems and facilities is important.
      Standards are necessary to guarantee the reliability and smooth function of the
      transport of newborns. Necessary personnel, costs, important equipment and
      indications were presented. Treatment for complications was discussed.

PMID- 1014774
TI  - [Transporation of high-risk new borns (author's transl)].
AB  - Organisation and results of a mobile intensive unit for high-risk neonates are
      reported. Within one year 134 transporations were required. Temperatures of the
      incubator from the beginning and the end of the transports as well as body
      temperature, blood gas analysis and blood sugar concentration of the neonates at
      arrival were choosen for quality control. The mortality of the newborn infants
      after admission was evaluated. The indications for transportation of severely ill
      infants are listed and the transport equipment is described.

PMID- 1014775
TI  - [A mobile reanimation model (reanimationmobile) for initial newborn infant care].
AB  - A mobile unit for reanimation of the newborn is reported to be used alternatively
      in the deliveryroom or in the surgical tract. The following adventages are
      achieved: a large working plate easily accessible from three sides, a complete
      and variable instrumentation, an efficent warmth supply and the possibility for
      easy cleaning and desinfection.

PMID- 1014776
TI  - [Tissue-plasminogen-activators of maternal and fetal rat lungs after application
      of betamethasone or bromhexine-metabolite VIII (author's transl)].
AB  - Prenatal RDS-prevention is currently done by two substances: Corticosteroids and
      Bromhexine Metabolit VIII. The influence on fibrinolytic activity of these drugs
      in the fetal rat-lung was tested in vivo. The inhibitory effect against tissue
      fibrinogen-activator of Beta-methason was greater than this of Bromhexine
      Metabolit VIII.

PMID- 1014777
TI  - [The colloidosmotic pressure (cop) as a parameter of maternofetal fluid exchange
      (author's transl)].
AB  - Colloidosmotic pressure (COP), osmotic and hydrostatic pressures are important
      parameters in passive maternofetal fluid exchange. Using a new method (Hansen
      /Knauer-Osmometer), COP-measurements were carried out on maternal blood plasma
      (COP 355 +/- 55 mmH2O), fetal plasma (COP 290 +/- 51 mmH2O) and amniotic fluid
      COP 12.6 +/- 5.8 mmH2O) obtained of 30 pregnant women during delivery at term.
      The interpretation of the resulting pressure gradients must consider
      physiochemical properties of protein solutions and the "selectivity" of biologic
      and artificial membranes. Membrane osmometry registers pregnancy-specific protein
      alterations, yields additional information concerning the physiology and
      pathology of fluid exchange, and may continue advanced development of kybernetic
      model conceptions.

PMID- 1014778
TI  - [Problems regarding gasometric analysis when umbilical cord blood specimens are
      stored (author's transl)].
AB  - If, as is often the case in routine practice, the gasometric analysis cannot be
      conducted immediately after withdrawal of the blood specimen, this does not have
      important consequences for the clinical. When the blood specimens are stored in
      open glass tubes, the alterations are all within the demands made of the method
      for measurement accuracy. As far as the purely clinical problem is concerned, it
      would even be possible to let the umbilical cord itself set for up to 90 minutes.
      Discrepancies between the gas status from blood specimens measured late and the
      Apgar score cannot be explained by storing and, insofar as errors in measurement
      are not involved, can represent an important piece of informations for the
      diagnosis of the condition of the newborn.

PMID- 1014779
TI  - [On-line fetal monitoring (meaning for data acquisition) (author's transl)].
AB  - We demonstrate an enlarged and modernized equipment for the on-line-fetal
      monitoring. With the aid of illustrations the received informations by help of
      continuous on-line-fetal monitoring are demonstrated too. They concerned the
      deposition of electronical and corresponding gasanalytical dates. The importance
      of registration from all obstetrical parameters and given up drugs by a code
      system is put out. Furthermore preferences of the computations are discussed.

PMID- 1014780
TI  - [External cephalic version using tocalytica (author's transl)].
AB  - 1. This report relates our experiences with 63 external versions of random breech
      or transverse presentations in cranial presentation between the 35th and 40th
      week of pregnancy p.m. using tocolytica. Only 22 of the 63 versions were
      successful when only tocolytica were administered. In 17 cases from a total of 34
      the external version was successful under subsequent general anasthesia. 2. Of
      these 39, in whose case an external version of the foetus was successful, there
      were only two caesarian deliveries. The number of caesarian sections in the case
      of breech presentation on the other hand totalled, in the year the present
      investigation was carried out, 62%. By external version the number of caesarian
      sections performed on those women whose external version was successful was
      indirectly reduced twelve-fold. 3. It was not possible to turn 24 of the total of
      63 foetuses - either by tocolytica or under general anaesthesia. The following
      factors - partly in combination - were responsible for this: 10 tendencies to
      contraction; 9 cases of a relatively narrow amniotic cavity: 3 cases of adiposity
      of the abdominal wall; 3 dorso-anterior or -posterior presentations; one case of
      "extended legs"; one relatively broad amniotic cavity. 4. An external version can
      cause damage to the placenta: a) in the case of 6 out of 22 women under
      obervation foetomaternal transfusion was detected. b) In once case materno-foetel
      transfusion with polyglobulism of the new-born was suspected. c) In one case a
      premature partial abruption of the placenta had to be assumed. The danger of
      damage to the placenta is especially great when the placenta is located next to
      the anterior wall of the uterus. 5. In 40% of the cases a brief deceleration of
      the foetal heart-frequency occurred immediately after the external version. Two
      cases were observed in which the foetal heart-frequency remained low over a
      period of several minutes. 6. In 5 out of the total of 63 cases a caesarian
      section was performed after the external version because of the danger of intra
      uterine asphyxia. There were 4 cases of chronic insufficiency of the placenta and
      one of premature abruption of the placenta. 7. Suggestions are made concerning
      the future selection of breech presentations for external versions.

PMID- 1014781
TI  - [The inhibition of spontaneous and oxytocin-stimulated uterine contractions in
      isolated rat uteri with diazoxide (author's transl)].
AB  - Diazoxide, a benzothiadizin derivative without diuretic effect, was tested for
      its tocolytic effectiveness in isolated uteri from pregnant and nonpregnant rats.
      Amplitude, frequency, basal tonus and duration of the total inhibition of labor
      pains were interpreted as parameters. Total or subtotal inhibition of amplitude
      and frequency could be obtained in all experiments. The duration of total
      inhibition of labor pains was between 3 and 27 minutes. Affect on the basal tonus
      was not consistant.

PMID- 1014782
TI  - [Demonstration of specific IgM antibody in cases of suspect congenital
      toxoplasmosis: interpretation of results (author's transl)].
AB  - From the aspect of laboratory Toxoplasmosis examination, a series of clinically
      and parasitologically confirmed cases of congenital Toxoplasmosis (CT) were
      selected. Serological findings (CFT, DT, IgM-IFAT) in infants and mothers were
      critically examined. The IgM titers in CT as a rule lay between 1:16 and 1:64,
      the highest recorded being 1:256. The serum IgM globulin levels showed no
      dependence on the high CFT titers. T recognize unspecific reactions amongst
      infants with positive IgM values, the serological testing of mothers was
      indispensable. It is also absolutely necessary with infants to repeatedly test
      serologically at intervals to clearly bring out the results of all the three
      serological reactions. The technical problems encountered for a definative
      diagnosis of CT and the clinical picture in the present critical examination are
      discussed.

PMID- 1014783
TI  - Bilirubin in liquor amnii. A rapid and exact method for quantitative
      determination.
AB  - A method is described for an exact and rapid determination of bilirubin in the
      amniotic fluid. Errors due to turbidity and to contamination of hemoglobin or
      debris are elliminated because bilirubin is extracted directely into chloroform
      by a special technique and determined by direct spectrophotometry. The new
      technique is related to the well known Liley procedure and the results with the
      new method are plotted into a modified Liley-sceme.

PMID- 1014784
TI  - [A case of ovarian struma found at a caesarean section (author's transl)].
AB  - A struma ovarii was diagnosed and excised during a Caesarean section. This seems
      to be the fifth case of such a tumor reported during pregnancy. The necessity of
      a routine inspection of the adnexe during Caesarean section is stressed.

PMID- 1014785
TI  - [The detection of prognostic factors in malignant melanoma - a documentation
      problem (proceedings)].

PMID- 1014786
TI  - [Penicillin sensitivity of Neisseria gonorrhoeae in the Munich region
      (proceedings)].

PMID- 1014787
TI  - [Current dose of penicillin for gonorrhea (proceedings)].

PMID- 1014788
TI  - [The development of hyphomycete cultures. A contribution to experimental mycology
      (proceedings)].

PMID- 1014789
TI  - [Immunosuppressive action of progesterone (proceedings)].

PMID- 1014790
TI  - [Problems of encoding histological findings - illustrated by malignant melanoma
      (proceedings)].

PMID- 1014791
TI  - [Documentation and diagnostic experiences (proceedings)].

PMID- 1014792
TI  - [Trends in the frequency of dermatoses (proceedings)].

PMID- 1014793
TI  - [X-ray therapy of dermatoses in the genital region (proceedings)].

PMID- 1014794
TI  - [Treatment of dermatoses with roentgen and beta rays (proceedings)].

PMID- 1014795
TI  - [Contribution of the Kiel skin clinic to the development of modern medical
      documentation (proceedings)].

PMID- 1014796
TI  - [New technical possibilities for dermatologic radiotherapy (proceedings)].

PMID- 1014797
TI  - [The function of eccrine sweat glands in human temperature regulation
      (proceedings)].

PMID- 1014798
TI  - [The significance of points in time of rehabilitation measures in the climate of
      the North Sea islands (proceedings)].

PMID- 1014799
TI  - [ST-line and T-wave changes unter influence of different digitalis doses within
      the therapeutic range (studies of patients with stress coronary insufficiency)].
AB  - ST-segmental depression below the isoelectric line in the ECG occurring under a
      therapy of sub-therapeutical and therapeutical digitalising doses, very often
      involves an increase of pre-existent stress stenocardia with cardiovascularily
      compensated patients having a coronary heart disease. For this purpose, 13
      patients of both sexes with latent coronary insufficiency were examined. The
      patients were treated with beta-Acetyldigoxin i.v. and were controlled under
      bicycle ergometric test-conditions before as well as during the different
      saturation phases with digitalis (0.66 +/- 0.03 mg, 1.20 +/- 0.07 mg and 1.54 +/-
      0.10 mg beta-Acetyldigoxin) in a miximum of 4 functional tests alltogether. Dose
      depent depression of the ST-segment accurred regularly accompanied by a reduction
      of the T-wave amplitude. A comparative valuation of myocardischemic and glycoside
      conditioned repolarisation disorders in the ECG demonstrated formalanalytically
      no differences concerning differential diagnosis. With the appearance of
      digitalis conditioned ST-T-changes an increase of angina pectoris could be
      proved. There were hints that the so-called adhesive signs of digitalis are an
      expression of myocardial ischemia and therefore principally of diagnostic value.

PMID- 1014800
TI  - [Effect of isosorbide dinitrate in relation to posture and age].
AB  - Rapid tilting into the 90 degrees upright position after 20 mg ISDN sublingually
      demonstrates a better orthostatic tolerance of the older group (in spite of a
      lower cardiac output) in comparison to the younger one. This can be explained by
      a higher tone of the resistance vessels and a stronger stretch resistance of the
      arteries of the elastic type (and probably of the veins), which are opposing the
      hydrostatic effects of orthostasis and guarantee a minor shifting of blood to the
      lower extremities. The increase of rigidity of the blood vessels with aging
      declares the better drug resistance of the older group but also points - on the
      other hand - to the borders of ISDN therapy.

PMID- 1014801
TI  - [Cardiodepressive effect of alcohol in low doses in normal persons and patients
      with coronary disease].
AB  - To study the effect of small amounts of ethanol 1 ml whisky (43 vol. %) per kg
      body weight was given to normal subjects (n = 11) and patients with coronary
      heart disease (n = 11) and the systolic time intervals (STI) PEP (preejection
      period), LVET (left ventricular ejection time), QS2 (total electromechanical
      systole) and PEP/LVET were measured. A control group consisted of five patients
      with coronary heart disease. The following results were obtained: Already at rest
      PEP/LVET was significantly higher in patients with coronary heart disease. After
      the ingestion of alcohol, significant changes of the STI were observed; mainly an
      increase of PEP and PEP-LVET was found. In patients with coronary heart disease
      the effect began earlier, was significantly higher and lasted significantly
      longer than in normal subjects. According to invasive correlation-studies of
      different authors, these results indicate an impairment of left ventricular
      function, especially of ejection fraction and contractility. These alterations
      seem to be more pronounced in patients with coronary heart disease. The results
      of this study should be considered in advising patients with coronary heart
      disease.

PMID- 1014802
TI  - [Hemodynamic concomitant effects of experimentally increased pulmonary capillary
      pressure].
AB  - An acute suprarenal occlusion of the aorta was produced in anaesthetized dogs by
      means of a ballon-tipped catheter. The resultant increase in wedge-pressure led
      to changes in pulmonary perfusion and raised O2 partial pressure in the arterial
      blood. The additional, simultaneous occlusion of the left subclavian artery by
      means of a second balloon-tipped catheter aggravated the haemodynamic
      manifestations of the pressure-load on the heart; but did not cause a
      proportionate increase in wedge pressure and O2 partial pressure.

PMID- 1014803
TI  - [The risk of heart disease in various psychiatric diseases].
AB  - The distribution of some risk factors on different psychiatric diseases in 1726
      hospitalized patients were investigated within a prevalence study. To all tested
      factors there was a contrary behaviour of oligophrenic patients opposite to the
      group with a schizophrenia, organic and affective psychotics. Hypertension only
      was found more frequently in non psychotic psychopathia and oligophrenia than in
      psychosis. Therefore the prevalence of hypertriglyceridemia,
      hypercholesterinemia, diabetes, specific Ecg-changes, smoking of cigarettes and
      severe physical inactivity in oligophrenics was less except in all other group of
      diseases, also in consideration of the different frequency of psychopharmacal
      treatment. Electrocardiographical signs for coronary heart diseases also show a
      similar distribution of frequency. Likewise in psychiatric patients seems to be
      an agreement with the coronary morbidity and the somatic risk factors.

PMID- 1014804
TI  - [Urinary excretion of the catecholamines adrenaline, noradrenaline and dopamine
      as well as the derivatives metanephrine and normetanephrine in heart disease
      patients].
AB  - In 20 normal persons and in 57 patients with heart diseases with functional class
      I-IV (according to the classification of the New York Heart Association) the 24
      hour urinary excretion of the catecholamines adrenaline, noradrenaline and
      dopamine and of the O2-methylated degradation products metanephrine and
      normetanephrine was determined. The 3 catecholamines and the 2 O-methylated
      derivatives were measured simultaneously using chromatographic extraction and
      purification (Bio-Rex 70) and selective flurometric determination. The following
      results could be obtained: 1. The urinary excretion of noradrenaline increased
      with increasing severity of the heart disease. 2. In patients with severe
      congestive heart failure (functional class IV) in addition the adrenaline
      excretion in addition the adrenaline excretion increased significantly. 3. There
      was no relationship between the urinary excretion of dopamine and the severity of
      the heart disease. 4. The ratio of noradrenaline excretion to dopamine excretion
      increased with increasing severity of the heart disease, indicating an increased
      activity of dopamine-mu-hydroxylation in patients with congestive heart failure.
      5. The excretion of the O-methylated degradation products metanephrine and
      normetanephrine in normal persons and in patients with heart diseases paralleled
      the excretion of the corresponding catecholamines adrenaline and noradrenaline.
      This indicates, that increased excretion of noradrenaline and adrenaline (Class
      IV) in patients with heart failure was not due to impaired catecholamine
      degradation but indead to increased catecholamine-release indicating increased
      sympatho-adrenergic activity. These results show in addition that also in
      patients with heart failure O-methylation represents still the main degradation
      step for the inactivation of the circulating catecholamines. 6. The relationship
      of toal excretion of 0-methylated derivates to total excretion of adrenaline and
      noradrenaline, however, decreased with increasing severity of heart disease,
      indicating a relative impairment of O-methylation under the condition of severe
      congestive heart failure.

PMID- 1014805
TI  - [Possibilities and prospects of general-practice medicine as compared to clinical
      medicine].

PMID- 1014806
TI  - [Trichomonas infections].

PMID- 1014807
TI  - [Roentgen diagnosis and clinical picture of esophagocardial carcinoma].

PMID- 1014808
TI  - [Clinical experience with Cerebrolysin in severe lesions of the cerebral cortex].

PMID- 1014809
TI  - [Treatment of syphilis with Bicillin-6].

PMID- 1014810
TI  - [Morphological changes in the skin during various stages and forms of lichen
      planus].

PMID- 1014811
TI  - [Free amino acids in blood of children with eczema and neurodermatitis].

PMID- 1014812
TI  - [Catecholamine excretion in children with eczema and neurodermatitis].

PMID- 1014813
TI  - [The acetylcholine-cholinesterase system in patients with disseminated
      neurodermatitis].

PMID- 1014814
TI  - [Ultrastructural changes in peripheral blood leukocytes in lupus erythematosus].

PMID- 1014815
TI  - [Seasonal changes in electrolyte metabolism of patients with psoriasis].

PMID- 1014816
TI  - [Diagnosis of gonorrhea using an asciteless nutient medium made with a dry
      extract of protein feed yeast].

PMID- 1014817
TI  - [Treatment of pemphigus with corticosteroids and methotrexate (literature
      review)].

PMID- 1014818
TI  - [Clinico-immunological evaluation of psoriasis treatment].

PMID- 1014819
TI  - [A case of ectodermal dysplasia].

PMID- 1014820
TI  - [Side effects of hormonal therapy in middle-aged and aged patients with eczema
      and pemphigus].

PMID- 1014821
TI  - [Enzyme activity of anaerobic glycolysis and the tricarbonic cycle in
      ichthyosis].

PMID- 1014822
TI  - [Immunoglobulins in children with eczema and neurodermatitis].

PMID- 1014823
TI  - Vitiligo and helminthiasis.

PMID- 1014824
TI  - [The pathogenesis of lower lip cancer].

PMID- 1014825
TI  - [Physiotherapeutic and balneological methods in the complex treatment of
      psoriatic arthropathy].

PMID- 1014826
TI  - [The therapeutic effectiveness of Fastine in the treatment of children with
      impetigo].

PMID- 1014827
TI  - [Exacerbation of chronic generalized (granulomatous) candidiasis due to incorrect
      therapy].

PMID- 1014828
TI  - [Phagedenic indurated chancre].

PMID- 1014829
TI  - [Corymbiform syphilid in a patient with secondary recurrent syphilis].

PMID- 1014830
TI  - [Treatment of syphilis in a patient with rheumatic heart disease and aortic
      coarctation].

PMID- 1014831
TI  - [Rifampicin therapy of gonococcal urethritis in men].

PMID- 1014832
TI  - [Urogenital trichomoniasis in women].

PMID- 1014833
TI  - [Skin tests with biologically active substances in psoriasis].

PMID- 1014834
TI  - [Histochemical studies of the skin in children with psoriasis].

PMID- 1014835
TI  - [Complement-fixing antibrain antibodies].

PMID- 1014836
TI  - [Ultrastructure of the normal skin in young children].

PMID- 1014837
TI  - [Data on an immunoglobulin study in syphilis].

PMID- 1014838
TI  - [Pathogenesis of alopecia and pigmented syphilid].

PMID- 1014839
TI  - [Pathogenesis and treatment of nongonorrheal urethritis in men].

PMID- 1014840
TI  - [Brocq's parapsoriases, their relationship to pokiloderma, mycosis fungoides and
      skin reticulosis].

PMID- 1014841
TI  - [Use of lincomycin in pyoderma].

PMID- 1014842
TI  - [Case of late congenital syphilis].

PMID- 1014844
TI  - [5-year-plan for health].

PMID- 1014843
TI  - [Griseofulvin resistance in microsporosis patients].

PMID- 1014845
TI  - [Immunoglobulin concentration in the oropharyngeal secretions of healthy
      subjects, patients with chronic tonsillitis and persons who have had their
      palatine tonsils removed].

PMID- 1014846
TI  - [Case of anaphylactic shock following administration of chymopsin].

PMID- 1014847
TI  - [Case of bilateral air cysts of the larynx and cyst of the trachea].

PMID- 1014848
TI  - [Fibroma of the trachea].

PMID- 1014849
TI  - [Case of Wegener's granulomatosis with long-term remission].

PMID- 1014850
TI  - [Skin cancer in a child in the region of a tracheostomy scar].

PMID- 1014851
TI  - [Breathing attachment for the tracheobronchoscope].

PMID- 1014852
TI  - [Apparatus KD-1 for objective assessment of the state of the mucous membrane of
      the upper respiratory tract].

PMID- 1014853
TI  - [Trepan puncture of the frontal sinus through a nasal approach].

PMID- 1014854
TI  - [Modification of a device for studying auditory function by a method of
      impedancometry using an ipsilateral acoustic stimulus].

PMID- 1014855
TI  - [Device for study of optokinetic nystagmus].

PMID- 1014856
TI  - [Role of immunoglobulins (A, G, M) in children with chronic tonsillitis].

PMID- 1014857
TI  - [Cytologic activity of tonsillar lymphocytes in chronic tonsillitis].

PMID- 1014858
TI  - [Serum sulfhydryl groups in children with chronic decompensated tonsillitis].

PMID- 1014859
TI  - [Thrombocyte function, fibrinolytic activity and blood loss following
      tonsillectomy in patients with chronic tonsillitis and rheumatism].

PMID- 1014860
TI  - [Several factors influencing blood loss during tonsillectomy].

PMID- 1014861
TI  - [Functional state of the thyroid gland in chronic tonsillitis before and after
      tonsillectomy].

PMID- 1014862
TI  - [Several biophysical indices of the state of circulation and external respiration
      in sportsmen with chronic tonsillitis].

PMID- 1014863
TI  - [Surgical treatment of midline laryngeal stenosis].

PMID- 1014864
TI  - [Proteolytic enzymes in palatine tonsil lymphocytes of patients with chronic
      tonsillitis].

PMID- 1014865
TI  - [Concentration of gonadotropic hormones in the serum of patients with laryngeal
      cancer].

PMID- 1014866
TI  - [Treatment of pigmented neoplasms of the auricular conchae with a ruby laser
      beam].

PMID- 1014867
TI  - [Use of lysozyme in several diseases of the otorhinolaryngeal organs].

PMID- 1014868
TI  - [Quality of diagnosis of otorhinolaryngologic diseases].

PMID- 1014869
TI  - [Failures in tympanoplasty].

PMID- 1014870
TI  - [Several problems arising with regard to radiation therapy of cancer of the
      larynx].

PMID- 1014871
TI  - [Otorheovasographic shifts in persons with occupational cochlear neuritis].

PMID- 1014872
TI  - [Water-electrolyte metabolism in patients with laryngeal neoplasms].

PMID- 1014873
TI  - [Myocardial energetics in children with tonsillogenic cardiomyopathy].

PMID- 1014874
TI  - [Effect of the microelements manganese and copper on vestibular nystagmus].

PMID- 1014875
TI  - [Effectiveness of dispensary treatment of patients with chronic tonsillitis].

PMID- 1014876
TI  - [Method of immobilizing fragments of the nasal skeleton].

PMID- 1014877
TI  - [Diagnosis and surgical treatment of recurrent midline fistulas and cysts of the
      neck].

PMID- 1014878
TI  - [Removal of foreign bodies from the respiratory pathways of children under
      general anesthesia].

PMID- 1014879
TI  - [Treatment of suppurative Highmoritis by long-term drainage].

PMID- 1014880
TI  - [Chronic suppurative epimesotympanitis complicated by multiple brain abscesses,
      spinal epidural abscess and transverse myelitis].

PMID- 1014881
TI  - [Arrosion hemorrhage from the common carotid artery as a sequela of phlegmon of
      the neck following tonsillectomy].

PMID- 1014882
TI  - [Case of fibrous osteodysplasia of the nasal bones and ethmoid labyrinth].

PMID- 1014883
TI  - [Reflection of the decision making process in evoked cortical electrical activity
      in man].
AB  - Averaged evoked potentials to visual stimuli of different significance were
      recorded in healthy adult subjects. The magnitude of the late positive potential
      (component P300), recorded in response to visual stimulus, greatly increases at
      the vertex, if the stimulus is given a significance for decision making (the
      choice of reaction). No such changes are recorded in the occipital area. In the
      case of decision making, the magnitude of the component P300 is clearly greater
      at the vertex as compared with the occipital area. No correlation has been found
      between the latency of the P300 and the reaction time, hence one should not refer
      to any coincidence between the temporal parameters of the potential and the
      process of decision making. The authors believe that the component P300 reflects
      not the very process of decision making, but a local cortical "non-specific"
      activation which is an indispensable element of the neural mechanism of decision
      making.

PMID- 1014884
TI  - [Effect of a constant and low frequency magnetic field on the behavioral and
      autonomic responses of the human operator].
AB  - The object of the study was conjugation of latencies of sensorimotor reactions
      and of following physiological characteristics: respiratory rate, heart rate,
      skin resistance and temperature, in man doing the work of operator, under the
      action of DC and AC (50 c/s) magnetic fields with maximal tension equalling 8-10
      a/m on the head. "Disfunction" of behavioural reactions and of their vegetative
      sufficiency was observed in the magnetic field. The degree of deterioration of
      control and compensatory properties of the central nervous system is of inverse
      dependence on the quality of the operator's work and the level of the central
      nervous system functional possibilities.

PMID- 1014885
TI  - [Stress on cardiac activity of students during course and national examinations].
AB  - Stress of the activity of the cardio-vascular system was studied in students at
      different stages of course and graduation examinations, by recording the changes
      in the pulse rate, systolic and diastolic pressure, pulse pressure, minute blood
      volume and peripheral resistance. The greatest stress on the cardiac activity was
      revealed before and after receiving the examination paper as well as during the
      answer. After the answer the cardiac activity rapidly reverted to the rest level.
      Graduation examinations caused more drastic and rapid functional shifts at
      decisive stages and at the same time a faster recovery than course examinations.

PMID- 1014886
TI  - [Informational characteristics of the impulse activity of cat sensomotor cortex
      neurons during elaboration of a defensive conditioned reflex].
AB  - Manifestations of the dynamics of defensive conditioning were studied in the cat
      sensorimotor cortical units. It has been shown that the process of learning is
      linked to the dynamics of the amount of total and useful information present in
      the evoked spike responses to a conditioned stimulus. As the pairings continue,
      the amount of useful information increases in reactions to conditioned or
      unconditioned stimuli and in the period preceding the conditioned stimulation.

PMID- 1014887
TI  - [Evoked potentials and spike activity of cortical neurons at the moment of
      conditioned reflex realization].
AB  - Experiments on alert rabbits have revealed a definite but dissimilar
      correspondence of amplitude-temporal dynamics of evoked potentials, neuroronal
      spike activity in the visual (VC) and the sensorimotor (SC) areas of the cerebral
      cortex and movements appearing in response to photic flashes, the conditioned
      signal (CS) of a defensive reflex. VC reaction to the CS sets in in 15 to 20
      msec. During the subsequent 20 to 40 msec, there is intensive VC activation and
      involvement in the reaction of most of the responding elements in the SC.
      Subsequently, the activation in VC weakens and increases in the SC. Against this
      background, movements in response to the CS appear with a latency of 60 to 120
      msec. The probability of movements in response to photic flashes decreases in the
      case of distinct phasic reactions to the CS in the period of deep inhibition and
      intensive postinhibitory activation of VC units. The data obtained imply that the
      SC neurones play a decisive role in the achievements of the defensive movement to
      the CS. As to the detection of the very fact of visual stimulation and to the
      modulation function and correction of the movement, they are provided for both by
      SC and VC neurones.

PMID- 1014888
TI  - [Role of the auditory cortex in animal recognition of synthesized vowels].
AB  - Discrimination of synthesized vowels [a] and [i] was studied in intact dogs and
      animals with an ablated auditory cortex. Electro-defensive and conditioned reflex
      methods were used. It has been found that as a result of learning an auditory
      image of a stationary vowel can be formed in intact dogs, which is invariant
      relatively to any change in the basic frequency of the voice, the intensity and
      duration of presentation (300 to 75 msec), and that two formants are sufficent
      for discrimination. The auditory image of the vowel is preserved after a
      bilateral ablation of the auditory cortical projection zone. Discrimination of
      vowels is disturbed in animals with a removed auditory cortex when information
      redundancy is reduced (diminished number of formants and reduced signal
      duration).

PMID- 1014889
TI  - [Inhibiting and facilitating influences from the caudate nucleus on alimentary
      conditioned reflexes].
AB  - Alimentary conditioned reflexes were studied in dogs during electrical
      stimulation of different zones of the caudate nucleus head with a 80 to 100
      microampere current, of 5 c/s frequency and 0.5 msec pulse duration. The
      inhibitory influences came from the ventrolateral, and the activating ones, from
      the dorsal and central zones of the caudate nucleus head. Changes of conditioned
      reflexes resulting from its stimulation depended on the strength of the
      conditioned signals: the conditioned reflex to a weak stimulus (light) was more
      readily subject to changes as compared with the one to a strong signal (a
      metronome). The magnitude of unconditioned reflexes did not change in these
      experiments.

PMID- 1014890
TI  - [Avoidance mechanisms during self stimulation].
AB  - Increased negative discordance of the dominating mode of the pressing duration
      histogram (PDH), which correlates with the growth of fixed bursts of stimulation
      is accompanied by a progressive decrease in the reinforcing properties of self
      stimulation (SS), avoidance of the pedal and at the same time by a change of
      behavioral grooming reactions in the intervals between SS for search and
      consummatory reactions. Hunger considerably shortens the preferable duration of
      pressing or leads to the appearance of an additional mode on the PDH. With the
      change of the dominating PDH mode from positive discordance to a negative one,
      brain stimulation acquires aversive properties which are apparently due to the
      activation of the mechanisms of specific motivations.

PMID- 1014891
TI  - [Effect of separate and simultaneous stimulation of limbic structures on
      emotions].
AB  - Organization of the central apparatus of emotional reactions was studied by the
      self-stimulation method in an original modification. The data obtained attest
      that the nature of the initially obtained reaction after the stimulation of one
      of the structures determines the emotional significance of stimulation of the
      structures complex in the limbic brain. The "trigger" zones inducing simular
      emotional reactions are not equal either with regard to the level of emotional
      stress appearing during their stimulation or to "resistance" to the activation of
      the "trigger" zones of the opposite sign.

PMID- 1014892
TI  - [Elaboration of conditioned reflexes in dogs grown under conditions of partial
      intraspecies isolation].
AB  - New data are presented on the influence of relationships with representatives of
      the same species at early stages of ontogenesis on the higher nervous activity of
      adult dogs. It has been found that dogs raised up to one year with their coevals
      differ considerably less from the control dogs by the speed of elaboration and
      stability of complex conditioned reflexes than those raised in complete isolation
      beginning with the age of three months.

PMID- 1014893
TI  - [Effect of conditioned reflex defense training on the level of cholinesterase
      activity and weight of the rat brain].
AB  - Influence of conditioned electro-defensive training of different duration and
      intensity on the weight and biochemical characteristics (activity of
      acetylcholinesterase and butyrylcholinesterase) of different parts of the brain
      was studied in rats of various genetic lines. It has been shown that the minimal
      duration of training leading to changes in the investigated characteristics in
      the experimental rats as compared with the controls, amounted to 30 days.
      Positive correlation has been found between the capacity for learning, the weight
      of the cortex and the activity of its acetylcholinesterase. A different degree of
      changes in the indicated characteristics has been revealed in various lines of
      rats used in the experiments.

PMID- 1014894
TI  - [Pharmakologic analysis of the interrelationship between long-term and short-term
      memory in dogs with systems of conditioned reflexes].
AB  - It has been shown in experiments on dogs with elaborated integrated systems of
      conditioned reflexes (by Kupalov method) and choice reactions (by Hunter method);
      that the physiological mechanisms of short-term and long-term memory are not
      strictly isolated; they include some common biochemical structures and are
      interrelated. The action of amizyl or armin on the cholinoreceptors disturbs the
      short-term memory and some elements of the long-term conditioned memory: the
      duration of retention of traces from conditioned and unconditioned alimentary
      stimuli is reduced; regulation of the course of stabilized conditioned
      stereotypes is disturbed; differentiation and use of previous experience
      (extraction of data from long-term memory) are impeded.

PMID- 1014895
TI  - [Duration of unilaterally organized trace excitation following administration of
      sedative and stimulating substances].
AB  - In experiments on dogs with symmetrical parts of the tongue brought out by
      Abuladze method, a study was made of the duration of trace excitation after
      administration of drugs of a sedative (bromine, amizyl) and stimulating
      (caffeine, ezerine) effect. It has been found that with changes of symmetrically
      organized reflexes during the action of the sedative drugs the duration of trace
      excitation is halved or reduced to a third, and the adequate unilateral reaction
      is sooner restored. The action of the stimulating drugs, the duration of traces
      increases and the unilateral conditioned reaction becomes bilateral. It has been
      assumed that change in the duration of trace excitation, resulting from the
      indicated pharmacological tests is due to the influence of the drugs on the
      processes of interhemispheric irradiation and concentration.

PMID- 1014896
TI  - [Response of white rats with different types of higher nervous activity to acute
      hypoxic hypoxia].
AB  - Animals with high, low and medium resistance to hypoxia were selected by
      repetitive tests under a vacuum bell. It has been shown that most rats with high
      resistance to hypoxia are characterized by strong basic nervous processes. The
      majority of animals with low resistance and all the animals with medium
      resistance to hypoxia exhibit signs of the weak type higher nervous activity.

PMID- 1014897
TI  - [Human evoked potentials during perception of simple and complex visual stimuli].
AB  - Visual evoked potentials were recorded in children and juveniles with normal
      vision upon presentation of "blank" and checkboard patterns with different size
      of checkboard cells (10,20,40,60 and 120 angular minutes). A high degree of
      dependence was established both of early and later components on physical
      stimulus parameters: pattern structures (diffuse photic stimulus, checkboard
      pattern), the number of contrast borders (different sizes of checkboard cells).
      Maximal EP was recorded upon presentation of checkboard patterns with cells of 20
      to 60 angular minutes. This is discussed as related to the size of receptive
      fields in man. Attraction and distraction of attention, while causing some
      amplitude changes mainly in later components (V and VII) amplitude did not
      considerably influence the EP configuration.

PMID- 1014898
TI  - [Motor representation of the limbs in the rabbit cerebral cortex].
AB  - Movements elicited by electrical stimulation (ES) of the brain's dorsal surface
      (train duration 20 msec, frequency 200 c/s) were studied in unanaesthetized
      slightly fixed rabbits. The stimuli were led through 80 mu in diameter electrodes
      implanted in the cortex. The responses were estimated visually or
      electromyographycally. The local responses of the forelimb (FL) were elicited by
      ES of an area with coordinates A 1-2, L 1-4; local movements of the hind limb
      (HL)--P 2,5-3,5 L 1-4. Between these areas there is a region whose stimulation
      caused the movements of the fore- and hind limb simultaneously ("overlapping
      area"). The thresholds and latencies of the forelimb responses were minimal when
      the stimuli were applied to the "local responses area". However, the tresholds
      and latencies of hindlimb responses were higher when stimulation was applied in
      the "local responses area" as compared with the "overlapping area". Light
      barbiturate anaesthesia (20 to 25 mg/kg) raised the thresholds of hindlimb
      movements 13 to 18 times when the stimuli were applied to the "local responses
      area", and 7 to 8 times, when they were applied to the "overlapping area". The
      problem of determination of the rabbit "motor centre" is discussed.

PMID- 1014899
TI  - [Comparative characteristics of the topography of functional interhemispheric
      asymmetry in the visual cortex following exposure to stimuli of different
      strength].
AB  - It has been shown that most animals exhibit functional interhemispheric asymmetry
      in the visual cortex, which increases with a rise in the intensity of photic
      stimulation. Interhemispheric asymmetry is characterized by its bilateral origin
      and mozaic localization. In the intact brain the transcallosal mechanisms provide
      for weakening a weak asymmetry and intensifying a strong one. This is due to
      different lateralization of the excitation focus which possesses dominant
      properties. A conclusion has been drawn that one of the functions of the callosal
      body consists in modulating the functional interhemispheric asymmetry.

PMID- 1014900
TI  - [Effect of stimulation of rostral portions of the midbrain reticular formation on
      the cat motor cortex].
AB  - Evoked potentials and responses of 139 neurones in the sensorimotor cortex (the
      lateral third of the posterior sigmoid gyrus) to electrical stimulation of the
      dorsolateral (DL) and the ventromedial (VM) areas of the mesencephalic reticular
      formation (MRF) were investigated in cats in acute and chronic experiments.
      Latencies of the cortical unit responses (in the form of single and multiple
      discharges) to MRF stimulation varied from 4 to 36 msec for VM (maxima of
      distribution: 4--10 and 18--24 msec); those for DL were from 4 to 26 msec (maxima
      of distribution: 4--6 and 14--16 msec). Responses to both DL and VM stimulation
      were observed in 29 neurones. As for MRF, its effects (mono-and polyvalent) were
      found in cortical neurones responding to limb electrocutaneous stimulation as
      well. At 7--10 days after coagulation of the ipsilateral connection between MRF
      and the pons, persistence of the cortical response main components was recorded,
      the long-latency part being slightly reduced.

PMID- 1014901
TI  - [Effect of microiontophoretic application of serotonin on the background impulse
      activity of visual cortex neurons in unanesthetized cats].
AB  - Sustained spike activity of neurones in the visual area (field 17) of the
      cerebral cortex and its changes induced by microionophoresis of serotonin was
      studied in experiments on unanaesthetized cats immobilized with diplacine.
      Neurones of field 17 with sustained activity are characterized by non-rhythmic,
      low-frequency discharges of a mixed type. 55 per cent of the studied neurones
      were sensitive to serotonin. They exhibited excitatory, inhibitory and phasic
      responses. The points discussed are: the importance of intracortical interactions
      between neurones in mechanisms of generation of their sustained spike activity,
      and the possible ;nvolvement of serotonin in ;he neurochemical processes of
      synaptic transmission in the visual area of the cerebral cortex.

PMID- 1014902
TI  - [Effect of disconnecting cortical input on the activity of hippocampal neurons].
AB  - Extracellular investigation of the CA1 and CA3 hippocampal neurones was performed
      in rabbits after complete bilateral transection of the perforant path (PP).
      Spontaneous activity was normal, but in a large group of neurones (38 per cent in
      CA1 and 43 per cent in CA3) rhythmic theta-bursts were observed, while in the
      normal state such neurones constituted only 9--12 per cent. The reactivity to
      sensory stimuli was enhanced, as well as the number of multimodal units. In both
      fields the majority of sensory reactions was of the tonic type; the number of
      phasic and "specific" effects, which are typical of the normal CA1 neurons, was
      strongly reduced. As a result, the CA1 field without PP closely resembled the
      normal field CA3. The phenomenon of gradual habituation of reactions was
      virtually absent; instead of that increase of reactions duration was obvious
      during repeated presentations of stimuli. The neurons were highly reactive to
      electrical stimulation of midbrain RF and displayed high correlation of
      characteristics of their reactions to sensory and reticular stimuli.

PMID- 1014903
TI  - [Role of visual impulsation on the age-dependent receptor properties of
      synaptosomal membranes].
AB  - An investigation was made into the activity of interaction of serotonin and
      tryptamine with synaptosomes isolated from the visual system of the rabbit brain.
      It has been found that the synaptosomes of the visual cortex and the anterior
      colliculi of normal rabbits are characterized by a higher activity in
      indoleamines binding than those of other parts of the cortex. Early visual
      deprivation caused a drop in the activity of interaction between the indoleamines
      and synaptosomes of all the investigated brain regions, more pronounced in the
      case of the synaptosomes of the visual analyser structures. Recovery of the
      visual function helped to normalize the activity of the process. The above
      regular relationships between visual impulse activity and the activity of the
      transmitter--receptor interaction lead to the conclusion that serotonin plays a
      specific, apparently neuro-transmitting part in the visual system.

PMID- 1014904
TI  - [Change in the structural state of membrane-bound proteins in rat cerebral cortex
      synapses during learning].

PMID- 1014905
TI  - [Relationship between the frequency of self-stimulation in cats and the frequency
      of the stimulating impulses].

PMID- 1014906
TI  - [Effect of electroshock on the electrical activity on grape snail neurons].

PMID- 1014907
TI  - [Method of complex recording of the behavioral and autonomic reactions of rats
      during conduction of the "open field" test].

PMID- 1014908
TI  - [Simple digital-analog converter for physiological research].

PMID- 1014909
TI  - [Method of studying memory in rats based on the inborn response of sequential
      alternation of right- and left-sided runs].

PMID- 1014910
TI  - [Contribution to the psychoanalytic theory of exhibitionism].
AB  - Exhibitionism can be regarded as a cultural, social and psychological phenomenon.
      It is given a view of the theories in the literature. Once exhibitionism is a
      normal human phenomen, otherwise it is pathological, par example also a neurotic
      symptom. The early psychoanalytic theories describe exhibitionism as a
      "Psychoneurose" as a result of "Odiopussituation", "Kastrationskomplex" and
      "Inzestwunsch". Psychodynamically this is not satisfying. With the development of
      psychoanalytic theory, especially the importance of the pregenital phases,
      changes the classification of perversions. In this article, exhibitionism-- as a
      neurotic symptom -- is defined as a "schizoide Perversion" (Riemann), which
      causes can be find in a preoral, intentional phase. Naturally the treatment must
      be adapted to it.

PMID- 1014911
TI  - [Comments on "Another interpretation of the Oedipus complex" by Elishevah Pelled
      Pollak].

PMID- 1014912
TI  - [Sweating in psycho-vegetative disorders].
AB  - Four different types of transpiration which are to be found in psychophysic
      disturbances as well as in healthy are specified in correspondence to four basic
      forms of conflict life. Statistically a  significant relation was proved between
      three of these types of transpiration and three of the personality structures.
      Some ideas about the behavioristic context of transpiration are discussed on the
      background of examples from the cynological literature in lack of others.

PMID- 1014913
TI  - [Differential indications in the clinical field. Empirical study of management of
      indications for analytic individual and group psychotherapy respectively in a
      psychotherayp clinic ].
AB  - This  study aims at a systematic description of factors which influence the
      practice of differential indication between psycho-analytic individual and group
      therapy in apsychotherapeutic clinic. The self-description of inclinic patients
      for who individual therapy was indicated, was compared to the self-description of
      those who were expected to join a therapeutic group. Two personality-tests
      (Giessentest "GT" and Freiburger Personlichkeitsinventar "FPI") and a symptom
      questionnaire (Beschwerdenliste"BSB") were applicated. If the self-description fo
      patients is an important factor influencing differential indication, then a
      difference should be found in comparison of the self-description of both samples.
      The result is , that important differences are not to be found, and that,
      moreover the little differences are variable by the time. In conclusion, patient
      centered explorations give no sufficient explanation, why group therapy was
      indicated in some cases and individual therapy in others. Basing on these
      results, differential indication in clinical psychotherapy is defined as  an
      interactional process which is influenced by specific cognitive factors of the
      therapist and his clinical socialisation on the background of variable
      institution-bound experience.

PMID- 1014914
TI  - [Relationship between psychogenic symptomatology and intelligence].
AB  - Corresponding to variables "leading symptoms in the psychic area" and
      "psychosomatic diseases in a restricted sense" 493 patients have been divided in
      four groups. Taking the hypothesis that patients with a different symptomatic
      show different results in the HAWIE (Hamburg-Wechsler-Intelligence-Test for
      Adults) four groups have been compared corresponding to their HAWIE-scores. It
      turns out that patients with a psychic leading symptomatic without important
      somatic disease and patients with psychosomatic illness in a restricted sense
      without psychic symptoms showed better results compared with other patients in
      the verbal tests. For this correlations of the higher scores in the verbal part
      of the intelligence-test with the phenomena that the investigator more often
      found the diagnosis of a psychic leading symptom or a psychosomatic disease in a
      restricted sense the following interpretations are considered: 1. The
      innerpsychic effort connected with different psychogenic disorders is reflected
      in the cognitive efficiency. 2. The diagnosis of limited psychomatic illness is
      also a result of the verbal interaction of doctor(s) and patient.

PMID- 1014915
TI  - [Fractures in the trochanteric region--anatomic classification and biomechanical
      basis for their treatment].

PMID- 1014917
TI  - [Per-trochanteric fractures treated using nail-plate monoblocks].

PMID- 1014916
TI  - [Treatment of per-trochanteric fractures of the femur urinary a screwplate].

PMID- 1014918
TI  - [Ender's nailing. Technic and incidents].

PMID- 1014919
TI  - [Ender's method of nailing, results of experiences from Lyon].

PMID- 1014921
TI  - [Hip prosthesis in per-trochanteric fractures].

PMID- 1014920
TI  - [Epiphyseo-diaphyseal prosthesis of the femur in trochanteric fractures].

PMID- 1014922
TI  - [Experience in the osteosynthesis using Ender's elastic nails].

PMID- 1014923
TI  - [Limitation of orthopedic reduction in the treatment of fractures of the
      trochanteric region].

PMID- 1014924
TI  - [Problems in the treatment of per-trochanteric femoral fractures].

PMID- 1014925
TI  - [Osteotomy in shortening of the ulna in sequelae of Pouteau-Colles fractures].

PMID- 1014926
TI  - [Bacteriological sampling in conventional and air-tight operating rooms].

PMID- 1014927
TI  - [Value of arthrodesis in the treatment of calcaneal fractures].

PMID- 1014928
TI  - [Dialysis characteristics of guanidyl compounds. i. Dialysance study using
      guanidyl succinic acid].

PMID- 1014929
TI  - [Comparative morphological and radiological course observations on the skeletal
      system of dialysis patients].

PMID- 1014930
TI  - [Behavior of plasms renin activity, hemodynamic parameters and clearance values
      as influenced by orciprenaline and propranolol in patients with limited kidney
      function].

PMID- 1014931
TI  - [Highly effective short-term dialysis using 2 parallel-connected capillary
      dialysators type C-DAK4. 1. Clearances, efficiency and ultrafiltration].

PMID- 1014932
TI  - [Organization of a home dialysis program].

PMID- 1014933
TI  - [Electrolyte studies on erythrocytes in chronic renal insufficiency prior to and
      following hemodialysis using diclysates with varying electrolyte concentration].

PMID- 1014934
TI  - [Vesico-ureteral-renal reflux in chronic pyelonephritis].

PMID- 1014935
TI  - Invalid care in the dwarf mongoose (Helogale undulata rufula)
AB  - The responses of a captive family group of 12 Dwarf Mongooses (4 female and 8
      male) towards a sick group member were recorded daily for 3 h over a 38 day
      period (until the animal died), these data being compared with those for a
      comparable control period. Changes in feeding rank order, resting site, resting
      duration and grooming frequency and duration were found, these being to the
      advantage of the sick individual. The probable adaptive significance of such
      behaviour is discussed.

PMID- 1014936
TI  - [Analysis of pattern preferences in Japanese quail (Coturnix coturnix japonica;
      Galli, Aves) with reference to inborn and acquired components].
AB  - Japanese quails were examined as to whether inborn or environmental factors were
      decisive for visual white-black pattern preference. By different breeding
      conditions (patterning of the environment, sight contact with other quails,
      knowledge of the food form) it was found out that bright surfaces were preferred
      to dark ones; young quails preferred patterns resembling the plumage of their own
      species, whereas older ones favoured those corresponding to their favourite food.
      Furthermore, activities were compared between different age groups; there are
      parallels between the activity in the test apparatus and on the activity
      platform.

PMID- 1014937
TI  - Gastric ulceration in the ferret (Mustela furo L.).

PMID- 1014938
TI  - [Relation between stress and fertility in the laboratory mouse. Short
      communication].

PMID- 1014939
TI  - [Sex maturation in the female mouse--a genetic analysis using diallelic crosses].

PMID- 1014940
TI  - [Preparation of pure albumin and transferrin from rabbit serum using con A
      sepharose].

PMID- 1014941
TI  - A method for obtaining germ-free rodents by "wet hysterectomy".

PMID- 1014942
TI  - Morphological studies on the development of tracheal epithelium in the Syrian
      golden hamster. II. Electron microscopy: changing aspects of the chromatin
      structure.

PMID- 1014943
TI  - [Etiology of colitis and of rectal prolapse in the mouse].

PMID- 1014944
TI  - [Organizational problems of child health care in sanatorium-type Pioneer camps].

PMID- 1014945
TI  - [Organization of the wide use of intrauterine contraceptive agents].

PMID- 1014946
TI  - [Tasks of medical science in the light of the decisions of the 25th Congress of
      the CPSU].

PMID- 1014947
TI  - [Utilization of automated control systems in medicine].

PMID- 1014948
TI  - [Study of the economic effectiveness of the introduction of scientific work
      organization into hospital work practices].

PMID- 1014949
TI  - [Knowledge retention by medical students in the department of therapeutics].

PMID- 1014950
TI  - [Automated processing of information in a pediatric polyclinc].

PMID- 1014951
TI  - [Morbidity with temporary loss of work capacity in Moscow physicians depending on
      the system of medical service].

PMID- 1014952
TI  - [Hygienic problems in the field of environmental protection in Moscow].

PMID- 1014953
TI  - [Status and developmental prospects of cosmetological service].

PMID- 1014954
TI  - [Work experience of a neurology department based on a restructured district
      hospital].

PMID- 1014955
TI  - [Morbidity and the medical support for sailors during a prolonged cruise].

PMID- 1014956
TI  - [Social hygiene problems of a national population].

PMID- 1014957
TI  - [Late results of treating the sequelae of brain injuries].

PMID- 1014958
TI  - [Achievement in the institute in relation to certain factors influencing the
      choice of medical school].

PMID- 1014959
TI  - [Organization of inoculations against tetanus in the cities and districts of
      Kurgan Province].

PMID- 1014960
TI  - [Social hygiene aspects of the development of medical service to elderly
      persons].

PMID- 1014961
TI  - [State of health and work capacity of the middle-aged and elderly].

PMID- 1014962
TI  - [Comment on a discussion in "Beitrage zur Pathologie" of the GFR: "The situation
      of Pathology in Germany" (author's transl)].

PMID- 1014963
TI  - [Enzyme-histochemical findings in the reperfused heart muscle of the dog
      (author's transl)].
AB  - Enzyme-histochemical changes due to temporary ischemia of canin heart muscle with
      subsequent reperfusion of the ischemic damaged muscle are described. In relation
      to findings in the rat, the first enzyme-histochemical changes were observed
      after two hours of coronary artery ligation. These changes were more impressive
      after 4 hours of ligation. A further increase was caused by the reperfusion.

PMID- 1014964
TI  - [Coronary atherosclerosis, coronary thrombosis and myocardial in autopsy cases.
      Statistical studies. 3rd communication: relationship of coronary atherosclerosis
      of other arteries (author's transl)].
AB  - 28978 autopsy reports of young (after the 14th year of age) and adult patients
      autopsied during the period of 1.1 1951 until 31. 12. 1969 were scored for
      atherosclerotic changes of the aorta and other arteries. The association of
      changes of these vessels and coronary sclerosis was studied. All groups of
      atherosclerotic changes showed an increase during the observation period. The
      cases with sclerotic changes of the aorta and the other arteries also showed an
      increase, especially those in combination with severe coronary sclerosis. 6.15
      per cent of all cases showed a coronary sclerosis without further lesions of
      other vessels. Corresponding to the results of other authors we observed that in
      cases of atherosclerotic changes of several arteries mostly a atherosclerosis of
      all other vessels has to be taken into account.

PMID- 1014965
TI  - [Coronary atherosclerosis, coronary thrombosis and myocardial infarction in
      autopsy cases. 4th communication: coronary thrombosis (author's transl)].
AB  - 28978 cases of young (after the 14th year of age) and adult patients autopsied
      during the period from 1.1 1951 until 31. 12. 1969 in our Institute were scored
      for coronary thrombosis and analysed concerning frequency and distribution of age
      and sex, resp. In this material the evidence of morphological changes was proved
      by longitudinal dissection of the coronary vessels. We analysed the age of
      thrombi, the localization and the grading of coronary vessels occlusions.
      Coronary thrombi were found in 2,31 per cent of all autopsies (2,81 per cent in
      males,1,31 per cent in females). Coronary thromboses showed an increase during
      the observation period. These thrombi were found more frequently in younger
      patients. Most of the thrombi (62,20 per cent) were localized in the Arteria
      coronaria sinistra, 37,80 per cent we found in the Arteria coronaria dextra.
      Fresh thrombi (57,51 per cent) and those being in organization (42,49 per cent)
      were not significantly different. Obturating thromboses showed an increase. The
      numbers of non-obturating thromboses decreased during the observation period. Our
      findings correspond to similar results published in literature.

PMID- 1014966
TI  - [On the angio-architecture of intramuscularly implanted Yoshida-sarcoma in
      untreated and lithium carmine-treated rats (author's transl)].
AB  - Investigations were made on the angio-architecture of intramuscularily implanted
      Yoshida-sarcomas in untreated Wistar-rats and in animals treated with lithium
      carmine. The injected quantity of lithium carmine led to RES-activation according
      to the data in the literature. The presentation of the vessels was made by
      corrosion technique using the synthetic material KALLOCRYL after rinsing the
      vessels with the proper ester. The pre-existent vessels in the surrounding of the
      tumor showed an adaptation the expansive growth of the tumor. After starting the
      experiment the tumor-owned vessels showed an increasing tendency to grow out. The
      vessels of the treated animals rected in a more regularly and orientated course
      than those of the untreated animals. In the following time vascularisation in the
      untreated animals was considerably decreasing, whereas a clear vascularisation
      was evident in the treated animals until the end of the study. These different
      findings may be the expression of a local vascular reaction in the implanted
      tumor following RES-activation induced by lithium carmine.

PMID- 1014967
TI  - [Malignant stem-cell tumor of the pineal region with unusual differentiation
      (author's transl)].
AB  - Report on a boy aged 10 with a malignant mixed stem-cell tumor of the pineal
      region. The tumor consists of an adult teratoma, circuscribed teratocarcinoma,
      endodermal sinus-tumor-like, choriocarcinomatous and germinoma (pinealoma) tous
      parts. The various parts of this tumor demonstrate the multipotentiality of stem
      cells. Stem-cells produce similarly composed tumors also in other region.

PMID- 1014968
TI  - [About the correlation of clinical, endoscopical and biopsy findings in
      inflammatory alterations of the rectal mucosa (author's transl)].
AB  - Clinical, endoscopical and biopsy findings (of 725 samples of rectal mucosa) of
      two groups of patients with and without corresponding clinical complaints are
      compared and the conclusions are discussed, especially for morphologists. This
      examination perferably concerns the boderline between "still normal" and
      "inflammatory" findings.

PMID- 1014969
TI  - [The inverted papilloma of the urinary bladder (author's transl)].
AB  - Regarding the characteristics of the inverted papilloma of the urinary bladder a
      report is given on two of our own observations, and its histogenesis is
      discussed. Out of 41 reported cases 21 patients developed symptoms of bladder
      obstruction and 15 patients had macrohaematuria. With exception of two cases, all
      the tumors were localized in the bladder neck, they were mostly solitary and in
      some cases pedunculated. Microscopically they showed papillomatous structures
      growing inverted into the stroma with only little signs of proliferation as well
      as microcysts with PAS-positive material, and always they had distinct borders
      between epithelium and connective tissues. In 33 out of 41 cases control
      cytoscopy was performed between 6 months and 17 years after resection. Only one
      case showed recidivation of the tumor.

PMID- 1014970
TI  - [Epithelial sarcoma. Three case reports with a review of literature (author's
      transl)].
AB  - Starting from three own cases of an epithelioid sarcoma, the literature about
      this type of tumor is discussed. It occurs in males nearly three times as often
      as in females, with the maximum frequency between 20 and 29 years of age. Finger,
      hand, wrist and forearm are preferably affected with the epitheloid sarcoma. The
      microscopic features are: nodular growth, necroses and hemorrhages within the
      nodules, the tumor tissue consisting of spindle-type and epitheloid cells with
      spaces in between, and lymphocyte infiltrates and siderin deposits at the
      periphery. The neoplasm's cytogenesis is not known. With regard to the tumor, the
      differential diagnosis should make a clear-cut distinction particularly between
      inflammatory granulomas and benignant neoplasms. The tumor trends to reactivation
      to a large extent. Metastases are both lymphogenous and hematogenous. A radical
      surgical removal is strongly recommended.

PMID- 1014971
TI  - [Ultrastructural studies on differentiation and proliferation of mouse peritoneal
      macrophages (author's transl)].
AB  - Mouse peritoneal macrophages show considerable variations of the cell structure,
      but 98% of macrophages clearly differ from the other peritoneal exsudate cells.
      This part is reduced too 96% after i.p. injection of erythrocytes. The nature of
      the unclassified cells is discussed. A local proliferation is observed in 1% of
      peritoneal macrophages after injection of sheep erythrocytes, auto-erythrocytes
      and 0,9% NaC1-solution. After erythrocyte injection the proliferation begins with
      delay in time at the end of intracellular digestion.

PMID- 1014972
TI  - [Coronary artherosclerosis, coronary thrombosis and myocardial infarction in
      autopsy cases (author's transl)].
AB  - The autopsy reports of the Pathological Institute Erfurt of the period from 1.1.
      1951 untile 31.12. 1969 were scored for cases of coronary sclerosis and coronary
      thrombosis and analysed concerning frequency and distribution of age and sex,
      resp. In 3.97 per cent of all autopsies (4.93 per cent of men, 2.62 per cent of
      women) a coronary sclerosis was present in combination with a coronary
      thrombosis. Coronary thrombi appeared more frequent in severe coronary sclerosis
      (8.96%) than in weak or moderately severe coronary sclerosis (1.39%). Males
      suffered significantly more frequent from these forms of icaemic heart disease.
      Coronary thrombi were found more frequently in the left coronary artery (2.46%)
      than in the right coronary (1.51%). This difference was significant. Non
      obturating thromboses were more frequent than obturating ones and those being in
      organization were rarer than fresh thromboses. In all cases a decrease of the
      relative frequency of the coronary thrombosis with increasing age in men and
      women is detected.

PMID- 1014973
TI  - [Coronary atherosclerosis, coronary thrombosis and myocardial infarction in
      autopsy cases (author's transl)].
AB  - The autopsy reports of the Pathological Institute Erfurt of the period from 1. 1.
      1951 until 31. 12. 1969 were scored for cases of myocardial infarction which were
      analyed concerning frequency and distribution of age, and sex, resp. The
      informations were transferred to punched cards and processed with electronic data
      equipment. In 8.26 per cent of all autopsies (males 10.32 per cent, femals 5.78
      per cent) a myocardial infarction was present. During the period of nineteen
      years a significant increase of the myocardial infarctions was observed. Callous
      infarcts were more frequent than fresh and relapsing. Most of the infarcts were
      found in the posterior wall of the left ventricle.

PMID- 1014974
TI  - [A chordoma of sacrococcygeal region as a cause of nephrotic syndrome (author's
      transl)].
AB  - A case of nephrotic syndrome connected with a chordoma of the sacrococcygeal
      region in a man aged 27 is described. Biopsy of the kidney revealed a diffuse
      membranous glomerulonephritis. Immunofluoresecenc showed deposits of IgG
      immunoglobulin on the basal membrane of glomeruli. In the patient's serum
      autoantibodies against chordoma cells were found. Those were also IgG globulins.
      To our knowledge such a relation of chordoma and nephrotic syndrome has not been
      described yet.

PMID- 1014975
TI  - [Congenital laryngeal atresia with aplasia of trachea (author's transl)].
AB  - Case report of a rare congenital laryngeal atresia with aplasia of trachea and a
      large communication between bifurcatio tracheae and oesophagus in a 5 minutes old
      nearly mature male newborn. The formal pathogenesis of this abnormality is
      discussed by a short summary of the embryological development of larynx and
      trachea. This is the 16th case so far communicated in Literature.

PMID- 1014976
TI  - [Advances in the diagnosis of pancreatic affections. The endoscopic retrograde
      pancreaticography (author's transl)].
AB  - On the basis of our experience from 170 endoscopic retrograde cholangio
      pancreaticographies the value of this method for the diagnosis of pancreatic
      affections is confirmed. It permits the assessment of chronic pancreatitis. In
      the majority of cases a safe diagnosis of pancreatic tumours is possible when the
      clinical picture and additional X - ray procedures are also considered.

PMID- 1014977
TI  - [The fine needle biopsy, a safe method for intraoperative differentiation of
      tumours of the pancreas (author's transl)].
AB  - High diagnostic accuracy (with increasing experience up to 90 per cent) and the
      absence of complications characterize the fine needle biopsy of the pancreas so
      far applied to 92 patients. This cytodiagnostic method is of great clinical
      importance, especially, for the intraoperative differentiation of small tumours
      for which pancreatoduodenectomy is only indicated in cases of carcinomas.

PMID- 1014978
TI  - [Ultrasonography of pancreatic diseases (author's transl)].
AB  - The use of a modern ultrasonic equipment with real time and gray-scale technique
      enables a riskless and less time consuming examination of the pancreas. The
      accuracy of ultrasonography in the diagnosis of pancreatic diseases is
      demonstrated by a clinical study in comparison to the endoscopic retrograde
      pancreaticography. By ultrasonography it is not only possible, to detect an
      enlargement of the pancreas, but also to differentiate between the various
      diseases of the pancreas in about 75% of the cases. Follow up controls in acute
      pancreatitis and the simultaneous examination of the neighbouring organs in all
      cases of a pancreatic disease are an important aid for the decision of surgical
      treatment. The ultrasonic targeted fine needle aspiration biopsy seems to be a
      suitable method to establish a morphological diagnosis in certain pancreatic
      diseases too.

PMID- 1014979
TI  - [Pancreatic ascites (author's transl)].
AB  - Pancreatic ascites occurs in cases of pancreatic ducts being damaged or
      discontinued due to pancreatitis or pancreatic trauma. Serum amylase, amylase and
      protein levels in ascites fluid are found to be elevated in cases of pancreatic
      ascites and a pancreatogram made during the operation confirms it. Various
      operations and sometimes a simple abdominal drainage are performed for treating
      pancreatic ascites.

PMID- 1014980
TI  - [Douglas' abscess with ureteric obstruction (author's transl)].
AB  - In a 19 year old man with a single kidney the development of a large Douglas'
      abscess was followed by anuria; The various causes are discussed. It is resonable
      to assume, that the obstruction resulted from longitudinal tension of the ureter
      over the iliace vessels (iliac sign).

PMID- 1014981
TI  - [Appendicitis in more than 60 years old patients (author's transl)].
AB  - A report is given on the results of 668 appendectomies performed because of
      appendicitis from 1953 to 1974 in patients older than 60 years.-During the last
      years a considerable relative increase of seniors-appendectomy could be observed.
      During the period mentioned perforations came to 27.5% constantly.

PMID- 1014982
TI  - [Prognosis of perforated appendicitis (author's transl)].
AB  - In a total of 4000 appendectomies 302 cases of perforated appendicitis are
      reported. The rate of perforations amounts to 7,5%. The medium letality of
      perforated appendicitis amounted to 6,6% and increased with advancing years of
      age. Complications are analysed. Problems of treatment and prognosis are
      discussed.

PMID- 1014983
TI  - [Diseases of the extrahepatic bile-ducts with special reference to secondary
      biliary hepatitis (author's transls)].
AB  - 159 patients suffering from histologically proved cholangiogenic hepatitis have
      been observed for 3 to 10 years after operative sanitation of the extrahepatic
      bile ducts. Cholangio-enterostomy (choledochoduodenostomy) affects the prognosis
      of cholangio-hepatitis unfavourably.

PMID- 1014984
TI  - [Multiple carcinoma in colon and rectum (author's transl)].
AB  - 43 multiple carcinomas of the colon and rectum were studied. 20 of those tumours
      showed a simultaneous manifestation, and 23 of them a metachroneous one. The
      interval between primary and secondary manifestation varied from 1 to 17 years.
      This clearly demonstrates that even after a very long tumour-free interval a
      secondary manifestation of the carcinoma can still be possible. The high
      percentage of multiple carcinomas of the colon calls for a careful preoperative
      diagnosis and an extensive intraoperative exploration of the whole colon. After
      hospitalisation a repeated check-up (3 months) is needed in the outpatients
      department to detect any secondary or recurrent carcinoma at the very earliest
      stage. In this way we were able to find 23 metachroneous manifestations and 27
      recurrent carcinomas which were still resectable. The treatment of choice for
      polyposis coli is total colectomy.

PMID- 1014985
TI  - [The postoperative atonic bladder (author's transl)].
AB  - Urodynamic investigations in 96 patients with carcinoma of rectum showed that the
      term "postoperative atony" does not describe the measurable alterations following
      excision of the rectum. Postoperative mechanical disorders of micturition and
      neurogenic lesions were analysed under the aspect of future therapy.

PMID- 1014986
TI  - [Acute abdomen: spontaneous fornix rupture].

PMID- 1014987
TI  - [Simple method for the economical preparation of vacuum flasks for Redon
      drainage].

PMID- 1014988
TI  - [Lyophilized split pigskin for biological wound dressings (author's transl)].
AB  - Experimental and clinical investigations of an unviable split pigskin preserve,
      produced by a fairly simple industrial process, outline the following results:
      The skin preserve protects a wound surface against infection and prevents loss of
      fluid. The reaction of the wound surface is very restricted even after repeated
      application, whilst the viable pigskin releases a more intense host reaction.

PMID- 1014989
TI  - Modern aspects of shock-treatment in extensive burns (author's transl).
AB  - The best fluid-treatment is not yet found. Even the optimal fluid-treatment,
      however, can hardly be expected to entail drastic improvements of the prognosis
      in patients suffering from severe burns. Interest should be concentrated on the
      burned tissue. We believe to have proved that acute excision in the shock-phase
      is permissable.

PMID- 1014990
TI  - Prevention of burns and scalds in a developed country.

PMID- 1014991
TI  - [Non-osteogenic fibroma of bone (author's transl)].
AB  - The non-osteogenic fibroma of bone is comparatively rare, with its tumour
      character being indeterminate. It is always benign, has a characteristic X-ray
      and allows a reliable diagnosis to be made in almost all case. Surgical treatment
      is only exceptionally necessary because of the tendency for spontaneous healing.

PMID- 1014992
TI  - [Possibilities of surgical treatment of the postthrombotic syndrome (author's
      transl)].
AB  - 5% of the working population of the Federal Republic of Germany are suffering
      from a postthrombotic syndrome. Reconstructive venous surgery is only beginning
      to make progress as regards technique and number of cases. Over a period of four
      years and among a total of 2,000 cases of vascular surgery, there were only 112
      operations on the venous system. Unilateral occlusions of the iliac vein are
      reconstructed by Palma Operation. The results of such interventions can be
      improved by creating a temporary arteriovenous fistula (14 observed cases, 12 of
      them functionning). In cases of thrombotic occlusion of the femoral vein, the
      equilateral saphenous vein can be implanted into the popliteal vein, thus
      providing an unimpaired runoff for the pump of the calf muscles (May-Operation).
      In this procedure, better haemodynamic conditions for the permeability of the
      graft can also be created by a temporary arteriovenous fistula established
      between the distal saphenous vein and the posterior tibial artery behind the
      ankle (9 observed cases, 8 of them functionning).

PMID- 1014993
TI  - [Rupture of the diaphragm in combination with injuries of the abdomen and thorax
      (author's transl)].
AB  - In 55 closed injuries of the abdominal cavity and the thoracic cage 4 ruptures of
      the diaphragm occurred. Due to the noncharacteristic symptoms the rupture of the
      diaphragm is frequently mistaken. In many cases it is possible to close the
      rupture from the abdominal cavity.

PMID- 1014994
TI  - [Principles of therapy with antibiotics and chemotherapeutics].
AB  - Important aspects for the today therapy and prophylaxis with
      antibiotics/chemotherapeutics resp. are represented (choice of the antibiotic,
      treatment with antibiotic or sulphonamide, bacteriostatic or bactericidal
      activity, combination possibilities with examples). A strong indication for the
      application of chemotherapeutic agents is demanded. The necessity of careful
      sensitivity tests before instituting chemotherapy is emphasised. Reasons for the
      essentially economical application of drugs today are referred to. Especially is
      discussed the problem of transferable drug resistance, the resistance situation
      during therapy, and the problem of drug application outside medicine.

PMID- 1014995
TI  - [Blood gas analysis in surgical geriatric gynecology].
AB  - At 36 women ranging in age from 60 to 87 years, who received general anaesthesia
      for gynaecological operations, pO2 and acid-base-status were controlled before
      and two hours after operation and on the 1st and 3rd postoperative days. At these
      geriatric patients the results showed mean values of pO2 in relation to the age
      and normal parameters of the acid-base status. Comparing the abdominal and
      vaginal operations no significant differences could be found. The comparison
      between patients aged 60 to 69 years and these over 70 years showed only small
      but clinically insignificant differences of base excess. These beneficial results
      are the consequences of a successful, complications avoiding pre- and
      postoperative treatment.

PMID- 1014996
TI  - [Appendectomies during gynecologic laparotomies].
AB  - By means of 1460 operations we communicate about the suitableness of
      appendectomia during gynecological laparotomia.

PMID- 1014997
TI  - [An unusual hormone-active avarian tumor in a 3-year-old girl].
AB  - A case report on an unusual hormone producing ovarian tumor in a 3 year old girl
      with sexual precocity is given. The serum values of Estradiol and Progesterone
      were similar to those of mature women during the luteal phase. The LH values were
      normal, the 17-Ketosteroids and 17-Hydroxycorticosteroids were near the upper
      limit of the normal range. At laparotomy a smooth, encapsulated tumor of the left
      ovary, 12 cm in diameter, was removed by unilateral salpingo-oophorectomy.
      Hormone analyses of the blood of the ovarian vein as well as of necrotic parts of
      the tumor showed values of 3450 and 2750 pg/ml Estradiol, and 70 000 and 75 000
      pg/ml Progesterone respectively. Histiologically the tumor cells were growing in
      nests and broad columns, showing bizarre nuclei, abundant pathologic mitoses and
      patchy calcification. In places the tumor cells were forming follicle-like
      structures. Both the fat stain and the glycogen stain were positive.
      Histochemically the tumor showed a strong activity of 3beta-ol
      Steroiddehydrogenase. Postoperatively the signs of sexual precocity disappeared
      soon. The patient is now without complaints for 3 years. The diagnosis of a
      juvenile granulosa cell tumor (Scully) was given. The endocrine relations between
      sexual steroids and gonadotropin before and after surgery are discussed.

PMID- 1014998
TI  - [Psychometric studies on female patients during sterility counseling].
AB  - The application of the VNPI-test, i.e. neurosis screening, to 46 female patients
      attending consultations on sterility, is reported. For patients having normal
      genital organs, the test results indicated a neurotic personality at rate three
      times higher (52%) than for patients found to have pathological genitals (17%).
      This result is understood to confirm the opinion which, in addition to somatic
      causes, also accepts  a psychogenic etiology of sterility. Therefore, the
      importance of early psychological investigation is pointed out, which should not
      start as late as once all somatic efforts have failed.

PMID- 1014999
TI  - [Legal evaluation of heterologous insemination in the GRD].
AB  - Therapeutic heterologous inseminations violate neither the socialist law of the
      German Democratic Republic nor the standards of socialist moral. From the view of
      the G.D.R. family code and insemination child is considered as legitimate, as
      each other child born to a married couple. A later voidance of paternity because
      of the heterologous insemination is not possible for both, father and mother,
      from the very beginning disclaim it. According to the family code of the G.D.R.
      the donor is neither related to the child, nor his paternity can be determined
      later by legal proceedings. Because of this legal status insemination child or
      his parents cannot demand alimony from the sperm donor or the inseminator.

PMID- 1015000
TI  - [The practice of heterologous insemination in the treatment of androgenic
      sterility].
AB  - Except of adoption the heterologous insemination has for some years in the GDR
      been a part of the therapeutic possibilities of a couple's androgen sterility.
      However, there is no uniform conception on practical proceeding, juridical
      problems, selection of sperm donors and documentation of data. This paper
      describes the practical proceeding at the women's hospital of Berlin's Humboldt
      University (Charite). It contains, among other things, an indication list,
      regulations for medical examination, instruction and juridical securing of both
      the donor and the married couple. Documentation of data under special regard of
      professional discretion is also dealt with.

PMID- 1015001
TI  - [The syndrome of ovarian hypoplasia].
AB  - The authors, on the basis of broad and endocrinological studies and of
      histological investigation of the ovaries, performed in 21 women, described an
      uniform disease picture which allowes to delimit ovarian hypoplastic syndrome out
      of a group of patients with ovarial insufficiency. This syndrome is characterized
      by primary or secondary amenorrhoea, normal height, weak development of secondary
      sexfeatures, and by small ovaries which have the oval or roller, more seldom ball
      like or streaking form. The histological picture of the ovaries consist of
      fibrous stroma without generative elements or with a small number of primary
      follicles, but sometimes also with single growing Graaf's follicle. The excretion
      of estrogens is very low and in the case of gonadotrophins it increases.

PMID- 1015002
TI  - [Ultramicroscopic studies on the drainage system of the human corpus luteum].
AB  - The granulosa lutein cells of the human corpus luteum have a specialized system
      of drainage with a particularly formed extracellular space, by which the steroids
      pass into the capillary vessels. The extracellular space consists of two partial
      systems: First one finds, similar to the bile capillaries of the liver, lacune
      like widnings of the intercellular space, where numerous microvilli of the lining
      cells are to be found and which are lined by desmosomes and invaginations of the
      cell membrane. Second there exist relatively wide canals limited by a granular
      membrane forming a network of their own among the lutein cells. Both systems
      contact without direct communication. We believe that first the steroids pass
      into the intracellular lacunes by diffusion or active transport from where they
      reach the membrane-lined canals by help of the network they pass on to the
      pericapillar space from where they diffuse into the blood vessels.

PMID- 1015003
TI  - [Electron microscopic study on the proliferation and regression of the human
      endometrium following administration of a new depot estrogen ethinyl estradiol
      sulfonate].
AB  - The ultrastructure of endometrium was investigated after oral application of 1 or
      3 mg of the new depot oestrogen etinyloestradiolsulfonate by means of long time
      observation with biopsies on postmenopause women. Details of this experimental
      proliferation was described. The highest functional activity in the endometrial
      gland and stromal cells was found 3 weeks after intake. There was no difference
      between ultrastructure following exogenous and endogenous oestrogen action.
      Degenerative changes within mitochondria were observed earlier than the
      regression in light microscopical picture.

PMID- 1015004
TI  - [Histological and diagnostic criteria and incidence of endometritis in abrasion
      material].
AB  - At present the diagnosis "endometritis" is diagnosed too frequently by the
      histological examination of the endometrial biopsies. An essential cause is the
      misconstruction of cells of the endometrial stroma. This investigation is based
      on the histological diagnosis of 3729 endometrial biopsies. 229 cases represent
      changes of the endometrium after pregnancy (abortion, birth). Among 3500
      endometrial biopsies 9 cases (=0,3%) had been diagnosed as "nonspecific chronic
      endometritis". The histological signs of the endometritis are described.

PMID- 1015005
TI  - [Ambulatory vaginal tubal sterilization using a plastic clip with special
      reference to reversibility].
AB  - Report about 248 vaginal tubesterilizations with plastic clips. 94% were carried
      out in outpatients, no complications were observed. After removing plastic clips
      in animal experiments four rabbits became pregnancy.

PMID- 1015006
TI  - [Effect, hazards and risks of the new vaccination against tick-borne encephalitis
      (TBE) as calculated by special formulas (author's transl)].
AB  - The effect and risks of the vaccination against TBE virus was calculated by means
      of formulas for Q and D. Q considers the relation between total risk of
      unvaccinated and vaccinated persons and D the yearly difference in risks between
      unvaccinated and vaccinated members of a community. In recommendable vaccinations
      Q should exceed 1,0 and D should be greater than 0. Vaccination against TBE was
      performed by 2 injections at an interval of 4 weeks followed by a 3rd injection
      after 9 months. No major side effects were observed in vaccinations of about
      50,000 persons. After one injection only, the conversion rate was 76% and Q 4,17,
      after 2 injections the conversion rate was 96% and Q 25 and after the total
      course of 3 injections the conversion rate was 98% and Q was calculated to be 50.
      With respect to morbidity DM was 7,18 X 10(-5) and regarding mortality DL was 1,1
      X 10(-6). That means that proper vaccination of persons at risk in Austria could
      prevent 500-600 cases of encephalitis and approximately 8 deaths due to TBE per
      year. It was concluded that the new vaccination is effective and recommendable.
      Revaccinations will be necessary probably at intervals of 2-3 years, the exact
      time period still being under study.

PMID- 1015007
TI  - Delayed multiplication of Semliki forest virus in organ cultures of muscle from
      vaccinated mice.
AB  - Local immunity against the homologous virus was detected from the first until the
      third day of incubation in organ cultures of muscle from mice previously
      vaccinated with Semliki Forest Virus.

PMID- 1015008
TI  - [The propagation of swine fever virus in cultures of macrophages and lymphocytes
      of normal and immune pigs (author's transl)].
AB  - Swine fever virus is replicated in the cells of the lymphoid complex. During the
      course of the disease cell-destruction, leucopenia and a disturbance of globulin
      and transferrin production is described. In the case of recovering firstly the
      leucocyte population, specially the lymphocytes, later on antibody titer
      increase. The production of virus neutralizing antibodies is not recognizable to
      be the cause of a recovery, the latter seems to be initiated by the production of
      a newly formed cell population. Therefore macrophages and lymphocytes of normal
      and of swine fever immune pigs are compared respecting the virus replication in
      vitro. Hereby macrophage cultures did not show any differences. In contrast to
      these findings in the tissue cultures consisting of predominantly lymphocytes of
      normal animals the virus replication exceeded that of immune pigs. Further on in
      the lymphatic organs of pigs killed in the recovering state newly formed clones
      of lymphoid cells were detected, which did not show swine fever specific but a
      globulin specific fluorescence. Obviously during the reconvalescent state a
      population of immune relevant lymphocytes is being created, which is different of
      these of non-immune pigs, since swine fever virus is not propagated by them
      anymore.

PMID- 1015009
TI  - [Rubella vaccination with "Cendehill" and "RA 27/3". Reinfection of vaccinated
      and naturally immune persons compared with the infection rate of susceptible
      persons within a 3-resp. 5-year observation period (author's transl)].
AB  - Many investigators in Europe and the USA have usually found high rates of serum
      conversion after vaccination with the rubella vaccines Cendehill and RA 27/3, but
      the resistance of vaccinated individuals against superinfection without disease
      induced by wild virus strains under experimental or natural conditions seems to
      be very low; e.g. up to 80% of the vaccinees reacted with increasing titers of
      hemagglutination inhibiting antibodies after super-infection with a wild virus in
      a special epidemiological situation. In our two studies performed under natural
      conditions of infection including an observation period of three years resp. five
      years after vaccination a more favourable picture evolved, perhaps reflecting a
      different epidemiological situation, a different susceptibility or a less
      virulence of wild virus in our region: Three years after vaccination of 14 years
      old girls with Cendehill and RA 27/3 in a double blind trial a significant
      increase in the titers of hemagglutination inhibiting antibodies was observed
      after vaccination with Cendehill by the subcutaneous route in only 1,16% (1/86)
      and in 1,18% (1/85) after vaccination with RA 27/3 by the same route. In the same
      observation period the infection rate in a control group not protected by natural
      immunity or by vaccination was 54,72% (87/159) and in a second control group,
      protected by natural immunity 1,82% (3/165)...

PMID- 1015010
TI  - The nosocomial and occupational hepatitis type B infection in a chest disease
      hospital. A prospective study.
AB  - The results of a prospective study of hepatitis B infections among the patients
      of a Chest Disease Hospital are reported. A thousand and sixteen patients
      admitted during the twelve months study period were screened for the Hepatitis
      B(Surface)-Antigen(HBsAg) on admission and during the stay and were kept under
      epidemiological surveillance for six months following the discharge. The HBsAg
      prevalence was 3.54% on admission and the cumulative infection rate during the
      follow up period was 12.64 per 100 patients. The HBsAg prevalence on admission
      was significantly higher in males than in females, the susceptibility to
      infection found in the course of the study was in both sexes similar. The
      majority of infections was inapparent with the ratio of 8.6:1 of inapparent to
      clinically manifested forms. The incidence of viral hepatitis among the personnel
      was comparable to the incidence among the personnel of other hospital
      departments.

PMID- 1015011
TI  - Hepatitis B (surface) antigen and viral hepatitis in family contacts of acute
      hepatitis B patients.
AB  - The results of a follow up study among family contacts of acute hepatitis B
      patients are reported. The family members were tested for HBsAg in the time of
      hospitalization of the index case and after three months again, the families were
      kept under epidemiological surveillance for six months. 19 (4,54%) out of the 418
      persons screened for the first time were HBsAg-positive. The highest prevalence
      of HBsAg-positive persons was found in the families of patients without history
      of parenteral exposure. 5 (1%) of family contacts were hospitalized from 2 to 4
      months following admission of the index case. All were the spouses of index case
      patients and none of them had other history of parenteral exposures than blood
      sampling for purpose of this study. 2 (0,58%) cases of silent antigenaemia were
      found among the 344 persons examined at the second screening.

PMID- 1015012
TI  - Evaluation of three techniques for carbohydrate fermentation of Neisseriae.
AB  - Three different techniques to study carbohydrate fermentation by Neisseriae were
      compared using 226 strains: growth in semi-solid cystine trypticase agar, the
      rapid test in phosphate buffered solutions of carbohydrates and growth on slants
      of solid cystine trypticase agar. The latter method was found to be the easiest
      to perform and is more suited for smaller laboratories, since the media used may
      be stored for at least 2 months.

PMID- 1015013
TI  - Susceptibility of viridans streptococci of 27 antimicrobial agents.
AB  - One hundred and eighty strains of viridans Streptococci (Str. mitis, Str.
      salivarius, Str. MG, Str. SBE, Str. bovis, Str. equinus and Str. uberis) were
      isolated from mouth and upper respiratory tract secretions of humans at random in
      different parts of Poland. These strains were tested for susceptibility to 27
      antimicrobial agents. Analysis of results was performed with special reference to
      bacterial endocarditis, which is caused mostly by these microorganisms. At low
      minimal inhibitory concentrations, most effective antibiotics appeared
      amoxycillin, clindamycin, azidocillin, cephaloridine, ampicillin, erythromycin
      and penicillin G. Susceptibility to other penicillins and cephalosporins was much
      less pronounced. Small part of strains was highly susceptible to tetracyclines,
      whereas all other antimicrobial agents were practically ineffective.

PMID- 1015014
TI  - [Titration of antistreptolysin and control of its specificity in respect of
      percipitation reactions (author's transl)].
AB  - A method for the titration of antistreptolysin O (ASLO) is described that is
      assumed to be more rapid than the methods applied thus far. The authors are
      drawing attention to the non-specificity of this method and propose to use PRESLO
      which is easy to prepare and admits of quantitative evaluation, for a control of
      this non-specificity. Correlation between the two reactions were established by
      the authors in 2137 sera which was expressed mathematically and made subject to
      subsequent statistical evaluation.

PMID- 1015015
TI  - [Sorbose in Salmonella diagnosis (author's transl)].
AB  - From 1525 Salmonella strains checked for fermentation of sorbose the majority
      failed to attack this sugar or split it with distinct delay. None of these
      cultures showed production of acid from sorbose prior to the third day of
      incubation. In contrast, sorbose was attacked within 24 hours by 74 out of 100
      Ballerup-Bethesda strains. As an easy and reliable basis test combination for
      performing a minimal biochemical Salmonella diagnosis a series consisting of
      Kligler's medium and media containing urea, lysine, lactose, sucrose, sorbose,
      and salicin is suggested.

PMID- 1015016
TI  - [Investigations on the fatty acid composition of lipids from Salmonella minnesota
      S and R forms (author's transl)].
AB  - Non-covalently bound lipids were extracted from 2 Salmonella minnesota S forms
      and 5 R mutants (chemotype Ra-Re) isolated from these strains. The lipids were
      subsequently analysed with regard to fatty acid composition. The extracts were
      free of lipid A, as determined by absence of beta-hydroxymyristic acid. The fatty
      acid distribution in the lipids of the two S forms, cultivated at 37 degrees C to
      the beginning of the stationary phase of growth, agreed very closely, and the
      values corresponded to those reported in the literature for S. typhimurium. In
      contrast, there was a progressive reduction in the content of C17- and C19
      cyclopropane fatty acids, going from Ra-Rc mutants. The total cyclopropane fatty
      acids decreased from approximately 30% (Ra) to approximately 7% (Rc). The lipids
      from the Rd1 and the Re mutants had a fatty acid composition identical to that of
      the Rc mutant. The decrease in cyclopropane fatty acid content was compensated
      for in all strains by an increase in the corresponding unsaturated fatty acids
      (16:1; 18:1). Variations in the incubation temperature (30, 37, 41 degrees C)
      affected the ratio of the single fatty acids as determined for the Ra, Rc and Re
      mutants. The content of unsaturated fatty acids increased with the reduction in
      temperature, while the proportion of cyclopropane fatty acids decreased
      (stationary growth phase). These changes were much more pronounced with the Ra
      mutant than with the Rc and the Re mutants. The differences among the mutants
      with regard to fatty acid distribution were apparent at all temperature levels.
      In addition, the fatty acid composition of the lipids varied with the phase of
      growth, as already reported for E. coli and other gram-negative organisms. The
      content of cyclopropane fatty acids increased from the exponential to the
      stationary phases, with simultaneous reduction in the proportion of corresponding
      unsaturated fatty acids. Again, the lipid composition of the Ra mutant varied to
      a greater extent than did that of the Rc and the Re mutants. Similar changes
      appeared in the phosphatidyl ethanolamine fractions of the three mutants. There
      were also changes in the neutral lipids that agreed in part with those of the
      total lipids. The cause of the reduced cyclopropane fatty acid synthesis in S.
      minnesota R mutants possessing an incomplete LPS-core structure (Rb2-Re) is at
      present unknown. The physiological significance of these findings as well remains
      for the moment speculative, as the functional role of cyclopropane fatty acids in
      biological membranes has not yet been elucidated. Possible relations to membrane
      permeability and to transfer of antibiotics are discussed.

PMID- 1015017
TI  - Actinobacilli in domestic fowl.
AB  - Reports on haemolytic rods from salpingitis in hens and from organs of died
      chicks may be found since the year 1950 (Kjos-Hanssen). Correct systematic
      classification on these microorganisms is still lacked because not all relations
      to the nearest pasteurellae were known as well as the clear differences in the
      Pasteurella-Actinobacillus group. The authors have isolated 34 suspected strains
      from 14 localities; 25 strains were from salpingitis or internal organs of died
      fowl inclusively chicks, and 9 strains from choanas of pullets clinically
      healthy. Bacteriological, serological, chemical and biological tests gave the
      results as follows: 1) All strains exhibit fundamental properties of Pasteurella
      Actinobacillus group, and moreover, they show ability to grow on MacConkey agar
      with crystal violet (BioQuest) being a significant feature of the genus
      Actinobaccillus (Mraz, 1975). 2) From the nearest species Actinobacillus
      haemolyticus (Newsom and Cross, 1932) Mraz, 1969, they differ with expressive
      haemolysis on agar with sheep blood, single haemolytic zone on agar with lamb
      blood according to Smith (1962), structure of somatic antigen, with natural hosts
      (gallinaceous birds) and pathogenicity for 5-day-old chicks. The GC content in
      DNA was determined in the range 39,6-42,9% (mean value 41,5%). 3) The first who
      presumed an independent state of these microorganisms, was Kohlert (1968), from
      the work of which the epithet for correct name, i.e. Actinobacillus salpingitidis
      (Kohlert, 1968) comb. nov., was accepted.

PMID- 1015018
TI  - [A new possibility of "non-parenteral" (local) vaccination: immunization per
      wound (author's transl)].
AB  - Hitherto the term "non-parenteral" (local) vaccination meant all those modes of
      vaccination where the vaccine is applied on the skin or the mucous membranes. The
      most common types of local immunization are oral and nasal vaccination. Using
      model studies with the mouse immunization per wound was investigated as an
      alternative mode of vaccination. Immunization was done with tetanus-toxoid,
      efficiency was tested by challenge with 10 LD50 tetanus toxin. For immunization
      per wound only slightly higher antigen doses are necessary compared with
      subcutaneous immunization. A single subcutaneous vaccination with 2 Lf tetanus
      toxoid and a single application per wound of 10 Lf resulted in the same
      efficiency index of 100. Immunization per wound has to be carried out immediately
      after injury. It seems to be optimal within the first 3 to 5 hours. At a later
      time the same efficiency index can only be achieved by use of a higher antigen
      doses. Immunization per wound is possible with all kinds of wound, even with
      burns. Size of wound and wound-supply do not influence the efficacy of wound
      immunization. Immunization per wound does not disturb wound healing. The
      experiments reported here showed, for the first time, that immunization per wound
      is as effective as parenteral immunization. The most important advantage of wound
      immunization is the speed and ease with which it can be administered, a fact
      which predestines it for vaccination in emergency cases. In practice it will be
      useful to combine wound-vaccination with wound-sprays.

PMID- 1015019
TI  - Serological characteristics of the Leptospira serogroup Pomona. I. Factor
      analysis of the reference strains.
AB  - The factor analysis of the Leptospirae of the Pomona serogroup discloses the
      presence of 4 main factors in this group on the basis of which 4 serovars, namely
      pomona, mozdok, tropica and proechimys may be accepted in this group. It is
      proposed that the Monjakov and the LT 1026 strains be referred to the pomona
      serovar. One of the established main antigens (P-4) is of the complex nature
      containing both thermostable and thermolabile compounds.

PMID- 1015020
TI  - Serological characteristics of the Leptospira serogroup Pomona. II. Changes in
      the agglutination and absorption properties of the reference strains after
      formalin- and heat-inactivation.
AB  - After formalin or heat-inactivation for 30 minutes at 56 degrees C, the
      absorption properties of some Pomona serogroup strains diminish, which indicates
      that they have thermolabile (Pomona, CZ 299U and LT 796) or formalin-labile
      (Pomona and 5621) minor antigenic factors. The agglutination properties of the
      various strains change differently after inactivation though not in parallel with
      the absorption properties.

PMID- 1015021
TI  - Immunological and morphological analysis of sodium dodecyl sulfate extract of
      Leptospira.
AB  - Sodium dodecyl sulfate (SDS) extract of Leptospira interrogans serotype
      icterohaemorrhagiae strain Shibaura was fractionated by rate zonal centrifugation
      in sucrose density gradient, and the fractions were analysed immunologically and
      morphologically. Two main peaks of antigenic activities were obtained. The first
      peak showed activities of strong indirect hemagglutination (IHA), weak complement
      fixation (CF), and low production of agglutinin in mice, and produced 5
      precipitin lines in immunodiffusion with homologous strain antiserum. It gave
      only partial protection to guinea pigs. No recognizable structural components
      were found electron microscopically in the first peak. The second peak, on the
      other hand, showed no IHA activity, strong CF activity, high production of
      agglutinin in mice, and produced no precipitin line in immunodiffusion. It gave
      complete protection to guinea pigs. Membrane fragments of the enveloping sheath
      were found electron microscopically in the second peak. The protective activity
      of SDS extract of leptospira was thus intimately associated with the activityes
      of agglutinin production and CF, as well as with the membranous structures of the
      enveloping sheath.

PMID- 1015022
TI  - The dynamics of IgM- and IgG-antibodies in leptospiral infection in man.
AB  - The dynamics of specific agglutinating antibodies belonging to different classes
      of immunoglobulins in 1047 blood sera of 669 patients and persons who had
      recovered from leptospirosis was studied. 19S and 7S antibodies were found in
      sera of patients with simultaneous presence of Pomona and Grippotyphosa. The
      character of syntesis of specific leptospiral IgM and IgG antibodies correlated,
      but the concentration of the IgG was much lower. As a rule, IgM antibodies had a
      wide range of cross-reactions with leptospires of heterologous serogroups.
      However, IgG-antibodies in 85% of cases reacted with homologous leptospires only.

PMID- 1015023
TI  - Formation of antibodies and immunoglobulins of various classes in persons
      vaccinated with warm antileptospirosis polyvalent vaccine.
AB  - The results of the observations of 2 groups of 372 persons during 10 months
      showed that a twofold inoculation of corpuscular heated 6-valent antileptospiral
      vaccine ensures the formation of 19S-antibodies. The ratio 19S/7S antibodies was
      determined by inactivation of IgM agglutinins with the help of 2-mercaptoethanol.
      Quantitative content of immunolglobulins (G, A and M) was determined in parallel
      with the reaction of agglutination by the method of simple radial diffusion.
      Immunoglobulins of the class M in the serum of vaccinated persons increased as
      compared with control, whereas the content of IgG did not rise and that of IgA
      decreased.

PMID- 1015024
TI  - Studies on the role of sodium in the metabolism of halophilic leptospirae.
AB  - Data from studies of the metabolic mechanism of the sodium dependence of
      halophilic leptospirae revealed that the presence of sodium - 1) has no effect on
      the oxygen uptake when the microorganism is oxidizing endogeneous and exogeneous
      substrates; 2) is not involved in the multiplication phase; but 3) is of
      importance for keeping the cell structure intact.

PMID- 1015025
TI  - Ultrastructural changes in host cellular organelles in the course of the
      chlamydial developmental cycle.
AB  - Different stages in the chlamydial developmental cycle were correlated with
      cytopathic changes in host cellular organelles by ultrastructural analysis of
      infected cultured cells and cells of the intestinal mucosa of newborn calves.
      Four distinct morphologic forms of chlamydial development can be distinguished:
      elementary bodies, dispersing forms, reticulate bodies and condensing forms which
      proceed to form elementary bodies. From the stage of elementary body uptake
      through formation and multiplication of reticulate bodies, the host cellular
      changes consisted mainly of displacement of cellular organelles by the enlarging
      chlamydial inclusions in the cytoplasm of infected cells. Beginning with the
      formation of condensing forms and elementary bodies from 20 to 30 hours after
      infection, cellular organelles became altered and progressively damaged. The
      damage was initially degenerative and then necrotic. It consisted of loss of free
      ribosomes and polysomes, dilation and vesiculation of the endoplasmic reticulum
      network and vesiculation and loss of microvilli. The specific granules of
      enterochromaffin cells and the mucous droplets of goblet cells were reduced in
      number. The mitochondria and nuclei were affected last. The mitochondria became
      swollen and their cristae became fragmented. The nuclei of infected cells lost
      their normal chromatin pattern and proceeded to pyknosis and karyolysis. Rupture
      and lysis of cytoplasmic and inclusion membranes liberated the different
      chlamydial developmental forms. After release the elementary bodies remained
      ultrastructurally intact.

PMID- 1015026
TI  - Transferable gentamicin-tobramycin resistance in nosocomial strains of Proteus
      rettgeri from oncologic patients.

PMID- 1015027
TI  - Prostaglandins as possible mediators of fever genesis in man.
AB  - Prostaglandin concentrations of cerebrospinal fluid (CSF) of 38 febrile patients
      (from infants up to adults) were compared with those of 19 afebrile adult control
      persons. CSF samples were extracted and the prostaglandins groups of the extract
      separated by column chromatography. Concentrations of prostaglandins of the E and
      F series were estimated by radioimmunoassay. In CSF of all feverish patients with
      meningitis, pneumonia, or pyelonephritis about 2-fold higher concentrations of
      prostaglandin E (PGE) were found that in those of the afebrile control persons.
      In contrast, concentrations of prostaglandin F (PGF) in adults and infants
      remained largely unchanged during fever; Solely, in 4 of the 8 babies examined,
      concentrations of PGF were also increased besides those of PGE. Repeated
      estimations of prostaglandin concentrations in CSF from the same patients showed,
      that concentrations of PGE, which had been elevated during fever, normalized
      after defervescence. The height of fever and the concentrations of PGE in CSF
      tended to correlate in a dose related manner. In correspondence with the results
      of animal experiments prostaglandins of the E series seem to act as mediators of
      fever during infectious diseases also in man.

PMID- 1015028
TI  - [Electronic data processing in medical microbiology--a guide and some critical
      thoughts].
AB  - Applications of electron data processing in all fields of medicine and especially
      in medical microbiology are increasing rapidly. It seems important to discuss a
      guide for using such complicated electronical systems, because, on the one hand,
      computer applications in medicine are desirable for scientific reasons, but on
      the other hand few very costly and sophisticated projects had to be cancelled,
      after a shorter or longer time of implementation by reason of lack of co
      operation of medical collaborators. This paper puts on discussion such a guide
      for using electronic data processing in medical microbiology. It is proposed to
      put through the following tasks before introducing a computer system into a
      microbiological institution: a system analysis of the status quo, an objective
      determination of the set state, a system design and a cost-benefit analysis.
      Those tasks are described in detail and are illustrated to some extent by
      graphics and tables from own research for preparing a data processing system for
      medical microbiology. It is emphasized that beside hard- and software criteria of
      the desired computer system one has to pay attention to the problems of man
      machine engineering. The paper finishes with concrete propositions of proceeding
      when the computer system is implemented and shows possibilities of scientific
      data evaluation of a microbiological data base.

PMID- 1015029
TI  - [Decrease in efficiency after experimental virus encephalitis. Small scale
      experimental tests on mice and histologic evaluation (author's transl)].
AB  - Two different experiments were set up in order to test the efficiency of 281 mice
      which had been infected intracerebrally with yellow fever virus 17 D of various
      dilutions (10(-1)-10(-5)); the tests were run after two time periods (40--55 days
      after infection = I. date, and 97 and 160 days after infection = II. date). In
      the first experimental set-up the animals were to find their food in a labyrinth-
      after 24 hours without food, (Labyrinth Experiment, Fig. 1). The time was taken
      from the moment when the mouse was put into the cage until the moment when it ate
      from the food. 4.37 min, were considered to be "standard time". In the second
      experiment the mice were placed on a horizontal rod rotating round an axle
      (Rotating Rod Experiment, Fig. 2 a,b,c). The time was measured for how long the
      animals could stay on the rod. 90/10 sec., were ascertained as "standard time".
      The following results were obtained. The difference in time regarding the I. and
      II. date is clearly noticed by the experiment with the rotating rod. The
      performance time of the animals was almost doubled after the 2nd time period
      (Table 4a and b, Fig. 3a and b), i.e. the animals could stay on the rod almost
      twice as long as after the first time period, which means that the recovery
      process of the animals can be measured by means of the rod experiment. In this
      respect the experiment with the labyrinth is less suitable. The recovery of the
      animals as well as the residual damages depended on the inoculated virus
      dilutions (Table 5a and b, Fig. 4a and b, Tables 7 and 8, Fig 21a and b). The
      histologic findings of the animals show lesions in all regions of the Central
      Nerve System (Fig 6-20, Table 2). The deficiencies of the animals which are due
      to diffuse damages of the Central Nerve System are demonstrated by the rotating
      rod experiment, whereas the labyrinth experiment verifies the shortcomings of the
      cornu ammonis (olfactory brain). The rotating rod experiment is the more
      sensitive of the two models  as the majority of the lesions are distributed
      diffusely on the Central Nervous System. The severe lesions of the Central Nerve
      System which are supported by histologic findings - even 160 days after
      infection, are confirmed by the deficiencies in the performance processes of the
      animals (delayed damages). Discussion have taken place regarding whether the
      experimental results of the animals can be applied to assessing latent or delayed
      damages in children after an encephalitis. The latter could concern in how far
      the course of an encephalitis depends on the originating virus dosis and could
      also relate to the development of delayed damages. The knowledge regarding the
      formation of delayed damages, their assessment as well as the prevention of
      encephalitis in infants would thus be greatly improved. In order to judge
      therapeutic measures on animals the rotating rod experiment appears to be very
      suitable since each stage of the illness enables an assessment of the state of
      the disease.

PMID- 1015030
TI  - [Occurrence of Salmonella in healthy snakes and snake cadavers- isolation of a
      new Salmonella species belonging to the sub-genus IV (S. IV 18:Z36, Z38:-)
      (AUTHOR'S TRANSL)].
AB  - Forty-seven isolation attempts performed with 20 fecal samples of exotic snakes
      yielded 27 Salmonella species belonging to the sub-genus I-IV. The majority of
      isolates (78.7%), however, was identified as sub-genus III (Arizona). The snakes
      under study were hold captured for less than one year (one part) or for longer
      than one year. Bacteriological investigations of the 7 snakes studied, repeated 7
      to 21 months thereafter, revealed uniformly other Salmonella species in
      comparison to those found at primary examination. Necropsy investigations were
      performed with materials from 3 snakes. One Salmonella species (Arizona) was
      isolated from the colon of one snake presenting with massive necrotic enteritis.
      The results with blood, bile and other colon sections were negative. Several
      Salmonella species were found in the colon of two other snakes presenting with
      infiltrative and necrotic changes in the organs, but without any pathologic
      finding in the intestinal tract. A new Salmonella species belonging to the sub
      genus IV (S. IV 18:Z36, Z38:-) was recovered from fecal sample of a Black Mamba
      (Dendroaspis polylepis) and another Cascabel snake (Crotalus durissus
      terrificus).

PMID- 1015031
TI  - Studies on endotoxin of Erwinia herbicola and their biological activity.
AB  - The endotoxin (lipopolysaccharide) preparations were extracted by the BOIVIN
      method from 10 strains of Erwinia herbicola isolated from the air of grain mills
      and from human and animal sources. It was found in assays for biological activity
      that these preparations had true endotoxic properties: lethality for mice,
      ability to produce primary inflammatory lesions in rabbit skin and ability to
      prepare rabbit skin for the local SHWARTZMAN reaction. Endotoxins obtained from
      five E. herbicola isolates were highly toxic and had mouse LD50 values ranging
      from 0.23 to 0.50 mg. The reparations derived from the remaining five strains
      were less potent with LD50 values ranging from 0.96 to 2.83 mg. The endotoxins of
      E. herbicola caused primary skin lesions (edema and/or erythema) in rabbits in
      the mean threshold doses (SLD50) of 1.33 to 5.94 mug and had the ability to
      prepare the rabbit skin for the local SHWARTZMAN reaction in the mean threshold
      does (SPD50) of 2.97 to 95.0 mug. The endotoxic properties of the E. herbicola
      preparations were similar to those of simultaneously tested enterobacterial
      lipopolysaccharides. The results of the mouse toxicity tests were positively
      correlated with those of the rabbit skin tests. In the additional tests the
      single preparations of E. herbicola showed two other endotoxic properties:
      ability to produce hemorrhagic lesions in rabbit skin after mixing with
      epinephrine and lethal effect on chick embryo. A preliminary chemical analysis of
      the trichloroacetic extracts of E. herbicola revealed low nitrogen and high
      carbohydrate contents as well as the presence of the common monosaccharides,
      reported in literature for endotoxins of various gram-negative bacteria. The
      significance of the presence of endotoxins in the ubiquitous E. herbicola rods is
      discussed, particularly with respect to occupational health hazard resulting from
      inhalation of vegetable dusts containing these organisms.

PMID- 1015032
TI  - [Culture and differentiation of obligatory aerobic gram-negative rods from human
      material; a scheme for application in routine diagnosis (author's transl)].
AB  - The diagnosis of obligately aerobic Gram-negative rods in the clinical laboratory
      may encounter difficulties since media used for Enterobacteriacae are only
      partially usable for the diagnosis of this group of bacteria (Psuedomonas,
      Xanthomonas, Alcaligenes, Achromobacter, Brucella, Bordetella, Flavobacterium,
      Moraxella, Acinetobacter, and some still unnamed taxa). We have developed a
      diagnostic scheme, based on recent publications in the field and representing an
      extension of earlier tables from this and other laboratories, which attempts to
      classify a maximal number of obligately aerobic Gram-negative rods with a minimal
      number of tests. The scheme, employed on 4051 strains, used blood agar and
      MacConkey Agar as isolation media. Growth characteristics on these media and
      microscopic morphology may be of help, but only the type of growth on Triple
      Sugar Iron (or Kligler's) Agar is characteristic for the group as a whole (no
      growth in the butt, alkalinization or no pH change on the slant). A primary
      identification series employs tests for oxidase (Kovacs), oxidation of glucose
      and xylose (in OF medium), deoxyribonuclease and indole (in DNase Test Agar with
      Methyl Green), nitrate reduction (in Indole Nitrite Medium), motility (hanging
      drop), and fluorescein production (on Flo Agar). Results of Kirby-Bauer
      antimicrobial sensitivity testing serve as additional (colistin) or confirmatory
      criteria. Incubation is at 30 degrees C for 24-48 hrs. If a diagnosis is not
      possible than, a secondary series, including tests for lysine decarboxylase
      (tablets), 4 hr urease, esculin hydrolysis, growth at 42 C and on SS Agar,
      gelatin liquefaction, and flagellar staining may have to be used, and read after
      4-24 hrs at 30 degrees C. Five tables, drawn up according to oxidase, glucose,
      and xylose reactions, serve to identify the species or taxa. Biotypes cannot be
      differentiated. The scheme will need updating as more knowledge of these bacteria
      will become available.

PMID- 1015033
TI  - Complement-dependent hemolysis following hemagglutination by Erysipelothrix
      rhusiopathiae.
AB  - When fresh guinea pig serum is added to chicken red blood cells (RBC)
      agglutinated by E. rhusiopathiae, the RBC lyse. This indicates that the E.
      rhusiopathiae-RBC complex is capable of inducing an alternative pathway of
      complement activation.

PMID- 1015034
TI  - Electrophoresis of water-insoluble leptospiral proteins and the taxonomy of
      Leptospira.
AB  - The cellular debris obtained after lysis of Leptospira were solubilized by sodium
      dodecyl sulfate and studied by polyacrylamide electrophoresis, comparing the
      molecular weight and relative concentration of the protein bands. The percentage
      similarity of 30 characteristic bands from 21 Leptospira strains, belonging to
      the main pathogenic and some saprophytic serogroups, was calculated; A partial
      matching of the derived dendrogram with the other classifications was observed.

PMID- 1015035
TI  - [Influence of standardization upon the results of serological analysis of
      toxoplasmosis (author's transl)].
AB  - It is the purpose of this paper to determine whether the decline of the
      serologically verified acute Toxoplasma gondii infections observed since the late
      sixties and found in literature has been caused by epidemiological factors or
      whether the standardization of serological methods (10) introducted in 1966/66
      for the determination of antibodies specific to Toxoplasma gondii has been
      responsible. The paper is based on material  of the prospective study, "Pregnancy
      and child development" supported by the Deutsche Forschungsgemeinschaft (DFG).
      Mainly six laboratories did the serological analysis for antibodies against T.
      gondii from 1964 to 1970. The following results were obtained: 1. Laboratories
      using the standardization observed a decline of the highly positive dilution
      starting in 1968 (Fig. 1, Table 1). 2. The proportion of the samples positive in
      the dye test did not change (Fig. 1). 3. The proportion of sera reacting in the
      complement fixation test (CFT) with a dilution of 1:5 increased. But after
      introduction of the standardization more sera were analyzed by both the dye and
      complement fixation tests than before (Table 2, Fig. 2). 4. The proportion of
      sera found positive by the complement fixation test increased slightly up to 1968
      (Fig. 3). 5. Differences in the age structure (Fig. 4) or dietary habits of the
      group (Fig. 5) did not cause the changes in titer. 6. Therefore the
      standardization was introduced a considerable proportion of the sera showing dye
      test results of more than 1:1000 reacted negatively to the complement fixation
      test (Table 4). These cases were probably not acute infections. 7. When the
      standardization was introduced the difference between results of first and second
      analysis decreased for sera with titers smaller then 1:256 (increased of
      reliability) (Table 5, Fig. 7). 8. Complement fixation titer show an analogous
      behavior. (Table 7 and 8). The results detained above show that the decrease,
      observed since 1969, of the cases of acute Toxoplasma infections verified by
      serological methods is not caused by epidemiological but rather by methodical
      factors.

PMID- 1015036
TI  - [Consequences of malnutrition in prosperous countries (author's transl)].
AB  - In times of need the classical disease gout becomes extinct, in times of
      prosperity it becomes frequent although its incidence remains virtually
      restricted to families with a history of gout. This means that genetic factors
      and nutrition must combine in order that the disease may become manifest. This
      situation probably parallels that of nutritional anomalies of fat metabolism,
      which have not been investigated to the same degree, although this cannot be said
      with certainty. Consequently the changing habits of nutrition during the last 30
      years have led to the frequent incidence of metabolic disorders seldom found
      earlier. It is not forseeable whether further changes in our diet will give rise
      to further metabolic disorders. The physician, no matter whether he works as a
      clinician, hygienist or epidemiologist, who has to take care not only of the
      entire population but also of the individual, is faced with the problem of how to
      control this problem. Another question is whether the nutrition of the population
      may permissibly be changed to improve national health by political decisions
      which would affect not only those endangered but the rest of the population, too.
      Such changes will become indispensable in the future because the financial loss
      caused by alimentary diseases already amounts to several per cent of the gross
      national product. However, there remains the basic question as to why the
      increasing industrialization and the changed life style associated with it have
      so drastically altered our nutrition. Some of these changes are certainly
      unavoidable consequences of the technical development, above all in those sectors
      where technology has helped to produce better foodstuffs. One wonders, however,
      why massive public education has largely failed to prompt the German citizens to
      accept the repeated and often well-motivated advice. This is probably due to the
      fact that the human diet has been established over the decades both by tradition
      and by necessity. The hard times are over and the traditions are no longer alive,
      quite apart from the fact that today it would no longer be possible to eat as
      tradition demands. In such situations men ought to draw benefit from our store of
      well-founded knowledge; this, however, means that nutrition must become part of
      public education and as such it ought to be given as much weight as the majority
      of subjects presently taught at school.

PMID- 1015037
TI  - [Problems of establishing the toxicological risks represented by foreign
      substances in food (author's transl)].

PMID- 1015038
TI  - [Nutrition and cancer (author's transl)].
AB  - The problem of a relationship between nutrition and cancer has to be approached
      from two different points of view: 1. Direct effect of carcinogens present in
      foods or in food additives (direct carcinogenesis), 2. In-vivo synthesis of
      carcinogens caused by changes in metabolism due to altered dietary habits
      (indirect carcinogenesis). For the second mechanism, we have to make a
      distinction between the effects of nutritional deficiency and of nutritional
      excess. Some examples from animal experiments are presented. In man, possible
      relationships between nutrition and cancer are postulated mainly for tumors of
      the gastrointestinal tract and recently also for hormone-dependent cancers.
      Epidemiological evidence points to the major importance of the indirect way of
      carcinogenesis caused by specific nutritional deficiencies and excesses.
      Experimental studies in man are difficult to perform. Therefore, most hypotheses
      are based on statistical associations, and great caution is required in drawing
      inferences on causal relationships. Cancers of the upper and lower
      gastrointestinal tract epidemiologically behave in a different way, the former
      showing a marked decrease in most western countries, the latter a slight
      increase. The etiology of the cancers of the esophagus and stomach has still to
      be determined in spite of many hypotheses. Migrant studies show a major effect of
      environmental rather than genetic factors. Substantial differences in dietary
      habits between countries with high and low incidence of stomach cancer (Japan and
      United States) point to the importance of nutrition as an etiological factor with
      a high probability, but no specific dietary components have been identified so
      far. The same is true for cancer of the large bowel. Recent hypotheses suggest
      that dietary factors may relate to cancer of the colon by their effect on bile
      production and on the bacterial makeup of faeces which in turn might be
      transforming bile acids into active carcinogens. There is, however, disagreement
      about the specific dietary component responsible for this model of
      carcinogenesis. BURKITT stresses the importance of the lower consumption of
      dietary fiber, resulting in retarded bowel function and additional time for
      bacterial proliferation and degradation by bacteria of bile acids. WYNDER, on the
      other hand, explains the increased bile acid and neutral sterol excretion and
      microbial modification of these compounds with the high content of animal fat in
      the western diet. With hormone-dependent cancers (breast, endometrium, ovary,
      prostate), a correlation has been shown between body weight and height and breast
      cancer as well as between overweight and cancer of the endometrium. Which aspect
      of diet, if any, is responsible for changes in hormone metabolism, resulting in
      an increased risk of these cancers, is still to be proved. On the basis of
      current knowledge, it is extremely difficult to draw inferences for preventive
      action. Certainly, a cancer-preventing diet cannot be established...

PMID- 1015039
TI  - [Modern animal nutrition--dangers for the animal (author's transl)].
AB  - Undernourishment and malnutrition as well as nutritionally conditioned diseases
      are still the greatest risk factor for every domestic animal born. In less
      developed regions, overgrazing and monoculture crops pose new nutrition problems.
      In developed countries, animal populations are faced with new feedstuffs
      resulting from new technologies, with risks stemming from contamination and with
      exposure to various new substances. In order to allow for an evaluation of the
      modern feeding scene, several examples are given. Since a positive correlation
      between animal well-being and long term economic success is likely to exist,
      optimism seems indicated concerning the impact of modern feeding measures on the
      animal.

PMID- 1015040
TI  - [Contamination of fodder and corresponding alimentary policy regulations].
AB  - In the mid sixties a medical work group developed a prophalactic programme for
      children which provided for repeated checkups to detect particularly those
      defects which are likely to seriously jeopardise the physical and mental
      development of the child. For the selection of the checkup dates that age of the
      child was decisivie in which it was possible to inspect certain functional
      events. Since such examination programmes had to cover an entire class, a
      prerequisite to be met was to choose an as large a number of examiners as
      possible. This meant the prescription of methods of examination which were
      applicable to any private or paediatric practice. In view of the fact that the
      child's health is subject to quick changes it can never be the objective of such
      programmes to establish acute syndromes and detailed examination findings but to
      restrict prophylaxis to a selection of important diseases. Thus the medical
      objective remains limited to readily recognizable disturbances which undetected
      could severely interfere with the development of the child. It is also decisive
      for the extent of thew examination that it isrestricted to the search for such
      developmental disturbances as can be remedied effectively...

PMID- 1015041
TI  - [Problems associated with the prevention of cruelty to animals in modern
      livestock breeding (author's transl)].
AB  - Regulations for the protection of useful animals can be traced to the early
      history of Law. The reason for such regulations has hardly changed up to the
      present: the expedient incorporation of the animal into the hierachy of values of
      the prevailing times. Decisive impulses invariably originated from the legal
      conception, the need for legal protection as well as from the scientific
      conceptions of society. The development rarely took a linear course and was not
      without setbacks. The prevention of cruelty to animals has always been faced with
      particular conflicting situations. Our pluralistic society with its marked
      philosophy of profit-making has to face such a problem, in particular as a result
      of livestock keeping in modern systems. The necessity and legitimacy of a
      permanent supply of large quantities of high-grade animal foodstuffs to be
      offered to our present industrial society on a competitive and low-cost basis,
      have contributed to this development. The public and parliament have for some
      time been demanding a modern federal act for the prevention of cruelty to animals
      based on a technical conception allowing also those questions of animal
      protection related to the present keeping of useful animals to be integrated,
      thus achieving a gradual balancing of interests. Such an Animal Protection Act
      came into force on October 1, 1972. On account of its scientific orientation it
      prompts us to give renewed thought to many present-day ideas about the keeping of
      animals, especially of useful animals, employing modern systems. With this
      objective in mind the Act has already strongly influenced the developing
      international harmonization of provisions for Animal Protection. The problems
      linked with "Animal Protection/Keeping of Useful Animals" require a harmonization
      of the ethical, scientific, economic and legal aspects as an indispensable
      prerequisite. On the basis of expert opinions prepared by a group of specialists
      of the Federal Ministry of Agriculture on the minimum requirements to be
      satisfied by modern systems of fowl breeding, the various scientific basic
      concepts and evaluations are presented. The value of the information yielded by
      modern research into animal behaviour is emphasized in this connection. Future
      legal ordinances in accordance with Clause 13, para 1 of the Animal Protection
      Act of July 24, 1972 for the protection of useful animals kept in modern systems
      call for a particularly thorough scientific foundation which must also stand up
      to examination by the courts. The problems to be solved require comprehensive
      research. An urgent task for the near future will be to give the resolution of
      these problems a firm scientific base. In addition to the topical approach to the
      subject "Animal Protection/Keeping of Useful Animals", indications are given for
      a comprehensive approach which will prove indispensable in the future...

PMID- 1015042
TI  - [Psychohygienic problems of development in early childhood (author's transl)].
AB  - For a "social environmental protection" as one of the most urgent problems in
      infantile psychohygiene, the following conclusions should be taken into
      consideration: 1. In particular during the first years of life the development of
      the child is, within certain limits, sensitive to influences from the environment
      and therefore it can be fostered or disturbed from the outside. Congenital,
      prenatal, perinatal and postnatal injuries to the brain and sensory organs must
      be given great attention psychohygienically. 2. The social influences exercised
      on the child by persons of his environment, their availability, their emotional
      relationships and the development of a durable link predominate
      psychohygienically. In addition, the material security of young families and
      their type of accommodation (e.g. granting of loans to help set up a home) must
      be considered. 3. The possibilities of exercising a positive educational
      influence on a mentally and psychically sound development of the child as a
      person and member of society are greatest at the beginning of life and diminish
      during childhood. The effectiveness of negative educational and social
      interference factors is also subject to this rule from which again the necessity
      of adopting psychohygienic measures for the young child is derived. 4. The
      phenomenon of increasingly imbalanced behaviour of older children and juveniles
      which cause concern today, are as a rule symptoms of a chiefly environmentally
      determined disturbance upsetting the personality, which often originates in early
      childhood. Psychohygienic measures must be concentrated on this. 5. The
      inadequate care of young children accounting for one third of the population, a
      phenomenon which can be read in the statistical records and which has risen
      sharply during the last few years, makes it possible to forecast a further
      increase in developmental and behavioral disturbances of both an intellectual and
      psychological nature as well as in infantile and juvenile criminality in the
      coming years to an at present unimaginable extent. 6. In contrast to general
      opinion, the situation calls for an urgent fundamental revaluation of the
      importance of intrafamiliar social conditions of development and of the parental
      educational work on the small child, which to date, have been underestimated and
      neglected. At the same time many of the presently overrated extrafamiliar
      institutions of education and training for the older child need to be
      relativised. 7. The advances in developmental biology which allow us to realize
      the basic dependence of the future social fate of the individual - and thus the
      extent of disturbed social relationships in society - on the intrafamily
      conditions must become a political issue, if psychohygiene as ameans to prevent
      avoidable disturbances is to be taken seriously. Thus the securement of adequate
      intrafamily conditions with respect to development and upbringing, in particular
      of the young child, must head the list of social political priorities, also in
      times when money is in short supply. 8...

PMID- 1015043
TI  - [Prophylactic examination of infants (author's transl)].
AB  - In the mid sixties a medical work group developed a prophylactic programme for
      children which provided for repeated checkups to detect particularly those
      defects which are likely to seriously jeopardise the physical and mental
      development of the child. For the selection of the checkup dates that age of the
      child was decisive in which it was possible to inspect certain functional events.
      Since such examination programmes had to cover an entire class, a prerequisite to
      be met was to choose an as large a number of examiners as possible. This meant
      the prescription of methods of examination which were applicable to any private
      or paediatric practice. In view of the fact that the child's health is subject to
      quick changes it can never be the objective of such programmes to establish acute
      syndromes and detailed examination findings but to restrict prophylaxis to a
      selection of important diseases. Thus the medical objective remains limited to
      readily recognizable disturbances which undetected could severely interfere with
      the development of the child. It is also decisive for the extent of the
      examination that it is restricted to the search for such development disturbances
      as can be remedied effectively. A prerequisite for the effectiveness of the
      programme is the identity of examinations and the uniform documentation of the
      findings according to a compulsory scheme. These records will accompany the child
      during his first years of life. The examination book remains in the hands of the
      mother and is submitted to the physician at the time of a checkup so that the
      continuity in the establishment of findings is ensured even when the physician is
      changed. This prophylactic programme, which was introduced by the author to the
      German public in 1968, was meanwhile implemented and adopted by the German Social
      Sickness Fund by virtue of a Federal Act effective as on July 1st, 1971. At
      present the examination comprises 7 checkups during the first 4 years of life.
      Emphasis lies on the check for cerebral motor disturbances, congenital heart
      diseases, skeletal anomalies, metabolic disorders, auditory, logopaedic and
      visual defects and others. A report is given on the results, the critical
      evaluation and the possibility of improving the prophylactic programme.

PMID- 1015044
TI  - [Cleanliness Norms 1964-1975].
AB  - In 1964 the Institut fur Demoskopie Allensbach made a first survey taking stock
      of norms concerning cleanliness in the Federal Republic of Germany. At that time,
      78% of respondents thought that the vogue among young people of cultivating an
      unkempt look was past or on the wane (Table 1.). Today we know that this fashion
      was an indicator of more serious desires for change in many different areas like
      politics, sexual morality, education and that its high point was still to come.
      In the fall of 1975 a second survey, modelled on the one of 1964, was conducted.
      Again, it concentrated on norms, not on behavior. As expected, norms have changed
      over this period but not in a one-directional or simple manner. In general,
      people are much more large-minded about children's looks: neat, clean school
      dress, properly combed hair, clean shoes, all this and also holding their things
      in order has become less important in 1975 (Table 2). To carry a clean
      handkerchief is becoming oldfashioned (Table 3). On the other hand, principles of
      bringing-up children have not loosened concerning personal hygiene - brushing
      ones teeth, washing hands, feet, and neck, clean fingernails (Table 4). On one
      item related to protection of the environment, namely throwing around waste
      paper, standards have even become more strict (Table 5). With regard to school
      leavers, norms of personal hygiene have generally become more strict (Table 6).
      As living standards have gone up and the number of full bathrooms has risen from 
      42% to 75% of households, norms of personal hygiene have also increased: one warm
      bath a week seemed enough to 56% of adults in 1964, but to only 32% in 1975
      (Table 7). Also standards for changing underwear have changed a lot: in 1964 only
      12% of respondents said "every day", in 1975 48% said so (Table 8). Even more
      stringent norms are applied to young women (Tables 9/10). For comparison: 1964
      there were automatic washing machines in 16%, 1975 in 79% of households. Answers
      to questions which qualities men value especially in women and which qualities
      women value especially in men show a decrease in valutation of "cleanliness".
      These results can be interpreted in different ways (Tables 11/12). It seems,
      however, that "cleanliness" is not going out as a cultural value. We have found
      that young people today do not consider clean dress important but that they are
      probably better washed under their purposely neglected clothing than young people
      were ten years ago. As a nation, Germans still consider cleanliness to be a
      articularly German virtue, 1975 even more so than 1964 (Table 13). An association
      test, first made in March 1976, confirms this: When they hear "Germany", 68% of
      Germans think of "cleanliness" (Table 14).

PMID- 1015045
TI  - [Psychology of Hygiene: Rsult of a Comparative Study 1968/1976 (author's
      transl)].
AB  - Object of the investigation is: (1) the analysis of the behaviour observed in
      adults between 18 and 23 years of age regarding cleanliness, body hygiene and
      changing of underwear,and a comparison of the results with those for 1968; (2)
      Differential "diagnosis" of the relationship between the degree of cleanliness
      and the various styles of the upbringing received at the hands of the parents,
      the different assessment of the personal body image and of cleanliness-related
      values ("cleanliness ideology"). Main results of the investigation (1) In 1976,
      too, women remain cleaner than men; the latter, however, have clearly improved
      their daily washing habits (lower part of the body, feet) and have taken to
      changing their underwear, night clothes and coloured shirts more frequently. With
      respect to the frequency with which women change their underwear there has been
      no change. (2) With respect to body hygiene and cosmetic care, women are found to
      be making increasing use of mouth-wash, foam bath agents, face lotions and face
      milk, nail polish, while men are making more use of mouth-wash, bubble bath
      agents as well as deodorants. In contrast, women are making less use of lip
      sticks, eyebrow pencils, Eau de Cologne, (3) Women's behaviour with respect to
      the observed and evaluated parental upbringing and to their own body image is
      more differentiated: The 4-factor solution for women contrasts with the 3-factor
      solution for men. (4) Only a form of cleanliness training involving corporal
      punishment and associated with a tense or hostile relationship towards the mother
      or father cannot be correlated to a desirable observance of cleanliness. Other
      possible forms of cleanliness training including supervisory forms, do not
      prevent the learning and adoption of desirable  practices for achieving
      cleanliness. (5) Less clean women show a generally less pronounced body-feeling
      as manifested in active physical exercise in some sports disciplines and in body
      care. There is also a tendency towards a less motivating criticism of the figure
      and a lower degree of positive bodily sensibility. As far as men are concerned,
      the intensity of body hygiene is positively linked with the degree of superficial
      good grooming and the simultaneous dissatisfaction with the figure. (6)
      Cleanliness-related concepts (cleanliness ideology) e.g. health, work, generosity
      rectitude, authority, attractiveness, integrity etc., are, in their evaluation,
      influenced both by sex and by the hygienic behavior practiced.

PMID- 1015046
TI  - [Developments in vaccines for prophylactic use (author's transl)].
AB  - The epidemiologic background on which the efficacy of vaccines has to be
      considered shows that the mortality of infectious diseases in the first seventy
      years of our century was reduced to an extent which goes far beyond all other
      diseases. This trend is similar in all countries of comparable status of
      zivilization. Trends in morbidity may be different, but no sufficient
      documentation is available for morbidity of infectious diseases in this country.
      Developments of new vaccines for industrialized countries will show a change
      compared with the present vaccines. After introduction of vaccines against the
      big killers until 1950 disabling diseases were the more recent target of
      immunoprophylaxis such as poliomyelitis, measles, rubella, mumps. Vaccine
      efficiency was greatly increased by vaccination campaigns for which strategies
      and tactics were developed in an almost military fashion. Analysis of the future
      vaccines reveals a further change not only by additional antigens but by new
      target groups of the population to be protected. Not only will more vaccines be
      developed for adults but also for certain risk groups. More knowledge of immune
      defence mechanisms in such groups will be needed for the final success of such
      vaccines. Moreover immunoprophylaxis may even enable immunotherapy in future. The
      most dramatic effect of immunoprophylaxis is to be expected in the coming decades
      in the non-industrialized world. This will be effectuated not by the newer
      vaccines, but by products which we know already. It is the decision of WHO to
      include an "Expanded program of vaccination" into their help for developing
      countries. Here new technologies are under investigation which will procure a new
      round in vaccination tactics. Vaccination is planned by WHO not only to help to
      develop countries but to play a decisive role in the problem of over-population.
      Such expectations are based on the fact that in the industrialized world the
      birthrate fell while the infant survival rates rose. Vaccination then would be
      more than immunoprophylaxis; vaccination would have a place then among man's many
      intelligent answers to mankind's many natural problems.

PMID- 1015047
TI  - [The world-wide importance of animal epidemics (author's transl)].
AB  - At present, roughly 64 million horses, 1.2 billion cattle, 1 billion sheep, 670
      million pigs and some billion fowl are kept and large quantities of animal
      products are produced. Animal breeding still varies widely with regard to both
      geographical distribution and efficiency. The protection of animal keeping in all
      countries of the world from losses due to disease and protein deficiency as the
      main cause of malnutrition constitutes an economical and sanitary problem of
      primary importance. Veterinary medicine is called upon to help to solve it. The
      losses (direct and indirect) of animals caused by infectious and invasive disease
      are extremely high. All in all, the losses of animals due to diseases have been
      reduced by 15 to 20 per cent of the gross production in many countries, and they
      can be reduced further. However, in countries with less efficient stock farming,
      losses run into 30 to 40 per cent and, if no control measures are adopted, are
      likely to increase considerably. Communicable animal diseases can be propagated
      over large distances in many ways by direct or indirect routes. As public
      interests are involved, the diseases must be controlled by measures financed by
      the state. In the light of the multivarious economic interconnections between the
      countries of the world, cooperation on an international basis is thus needed.

PMID- 1015048
TI  - [Malnutrition as an international problem (author's transl)].
AB  - The importance of malnutrition as an international problem is illustrated by some
      examples. Attention is mainly focussed on the bipolarity of this problem:
      malnutrition, both qualitative and quantitative, as the main nutritional problem
      of most of the developing countries of the Third World, overfeeding nowadays so
      associated with qualitative malnutrition - as the most important alimentary
      problem in the Federal Republic of Germany, but applying equally to other highly
      industrialized and civilized countries in Western Europe, the United States and
      Australia. Perhaps it would be more to the point to speak of prosperous countries
      or populations because these diseases found in technically highly developed
      countries increasingly occur also in developing countries among those social
      classes who believe they are able to afford a "better" nutrition and fall from
      one extreme of malnutrition into the other. Correct nutrition considered to be a
      privilege or a direct consequence of social prosperity is certainly not
      justified. The improvement in the standard of living as such by no means
      guaranties well-balanced nutrition. To quote an example: in developing countries
      when people live by trading with certain limited products, alimentary habits tend
      to change when the prices of the products go up. However, this is by no means
      invariably a change for the better, but quite often for the worse. It has
      repeatedly been found that in tropical countries where copra is the staple
      trading product, nutrition did not improve as the copra price rose. On the
      contrary, nutrition deteriorated because the people increasingly turned from the
      self-cultivated "natural products" to imported, refined food stuffs and tinned
      foods purely for reasons of increased prestige associated with such a diet. The
      consequences of malnutrition in the developing countries are dealt with in
      greater detail. In dealing with the consequences of malnutrition in highly
      industrialized countries a restriction to a few pointers was necessary because
      this subject is discussed in the following paper.

PMID- 1015049
TI  - Pathogenetic and clinical observations in spinovascular insufficiency.
AB  - The data about the arterial spinal circulation in man are presented, some spinal
      syndromes "unexplained still today" in their pathogenesis are described, and the
      earlier attempts to formulate working hypotheses for the explanation of this
      spinovascular insufficiency are critically rediscussed.

PMID- 1015050
TI  - [Internal carotid artery occlusion - clinical-morphological correlations].
AB  - An attempt has been made by the authors to find correlations between the
      collateral circulation and clinical condition in thirty-three patients suffering
      from occlusions of the internal and common carotid arteries. It has been found
      that the course of disease will be less severe when a collateral circulation is
      developed; also, this results in late consequences being much less severe in
      character. The age and general condition of the patient were found to be of major
      importance to the course of disease. Patients of advanced age usually do not show
      any appreciable improvement even in those cases where a collateral circulation
      has developed. Anatomical examinations showed that there existed a large number
      of collateral circulations between the external carotid artery and the branches
      of the ophthalmic artery. Playing the most important role among these branches of
      the external carotid artery are the maxillary and facial arteries. This has also
      been confirmed by the results of angiographic examinations made in vivo. Also
      described in this paper are rare cases of development of collateral circulations
      which were reported in the literature and which may be considered as contributing
      to the compensation of conditions characterized by the occlusion of the internal
      carotid artery.

PMID- 1015051
TI  - [EEG after so-called whiplash injury of cervical vertebral column
      (cervicocephalic acceleration trauma)].
AB  - The results of electroencephalographic examinations made on four groups of
      patients are compared. These groups include 80 patients with cervicocephalic
      syndromes due to flinging injuries to the cervical vertebral column, 80 patients
      with postconcussive syndromes, and 39 patients whose anamneses suggested
      conditions resulting from the two kinds of injury referred to above. A fourth
      group of 40 patients with nontraumatic spondylosis deformans cervicalis is
      compared with the first three groups of patients. The rate (49 percent, 52
      percent, and 54 percent), kind, and distribution of electroencephalographically
      determined abnormalities are in agreement with those obtained for the first three
      groups. For patients with nontraumatic cervicocephalic syndromes the rate of
      general alterations determined from records obtained by means of the
      electroencephalograph is equal to the occurrence of constitutional EEG variants,
      the rate being of the order of 10 percent. EEG alterations observed in the case
      of flinging traumata are considered to de due to acceleration injuries to the
      cranial contents.

PMID- 1015052
TI  - [Fluid carbenicillin levels after intravenous administration].
AB  - Intravenous infusion of carbenicillin was followed by a determination of the
      concentration of this antibiotic in both the liquor and serum. The examinations,
      of which the results are reported in this paper, were made on six patients who
      had undergone surgical operations to the posterior cranial fossa and on whom
      lumbar punctures were postoperatively performed every day, as well as on seven
      hydrocephalic patients where a temporary relief of pressure was obtained by
      draining excess liquor. The level of carbenicillin in the liquor were found to
      enable even gram-negative problem germs (e.g., Proteus germs) to be controlled.

PMID- 1015053
TI  - [Indications for reoperation on brain gliomas].
AB  - The present results allow to make the following conclusions: (1) In the case of
      relapses or progressions of intracranial gliomata, reoperation usually yields
      unsatisfactory therapeutical results, often leading even to premature death of
      the patient. (2) Reoperations for intracranial gliomata should be decided
      individually. Determining their indication are the size, location, and
      histological character ascertained during the first intervention. Also, it is
      necessary to give detailed consideration to the results of both scintigraphic and
      angiographic examinations, which give an idea of the actual size of
      proliferation. (3) Relapses of malignant and relatively malignant gliomata are
      not reoperable. (4) Showing a relative capability of treatment by surgical
      reoperation are relapses of benign gliomata in functionally unimportant regions,
      which do not affect remote cerebral structures and which are accompanied by
      intracranial hypertension. (5) Reoperation is absolutely indicated in the case of
      relapses of spongioblastomata of the cerebellum providing the tumor does not
      affect the brain-stem.

PMID- 1015054
TI  - [Unusual paraventricular cavitations as complication of brain stem glioblastoma].
AB  - The author in his present paper reports extensive paraventricular cavitation of
      the lateral ventricles in a 24-year-old woman with a brain-stem glioblastoma.
      Playing an important etiopathogenetic role in the development of this particular
      complicatien are a disturbance of the pischarge of liquor due to the expansion in
      the posterior cranial fossa of the rapidly growing tumor, the internal
      hydrocephalus resulting therefrom, and the acute tumoral hemorrhage accompanied
      by an invasion of the fourth ventricle and partial internal hematocephalus.

PMID- 1015055
TI  - Experiments on the immune elimination of Irichinella spiralis in rats 3. Passive
      immunization.

PMID- 1015056
TI  - Antibody response against swine fever following vaccination with C-strain virus.

PMID- 1015057
TI  - [Reactivation of inhibited larvae of Ancylostoma caninum. Effect of estradiol and
      progesterone].

PMID- 1015058
TI  - [Effectiveness testing of lapinized live swine fever vaccines].

PMID- 1015059
TI  - [Development of the lingual vessels].

PMID- 1015060
TI  - The innervation of the tongue in the Indian buffalo (Bubalus bubalis).

PMID- 1015061
TI  - [Light microscopical studies on the cat skin. Distribution, grouping, and
      morphology of the hairs and hair follicles].

PMID- 1015062
TI  - [The sympathetic trunk and its branches to the abdominal and pelvic viscera in
      the gerbil (Meriones unguiculatus)].

PMID- 1015063
TI  - [Distribution of glycosidases in genital tract of the rooster (Gallus
      domesticus)].

PMID- 1015064
TI  - [Arterial vascularization of the intestines of American beaver (Castor
      canadensis, Kuhl)].

PMID- 1015065
TI  - Some morphological variations in the venous circulation of the choroidea in man.

PMID- 1015066
TI  - [Use of aliphatic amino acids by staphylococcus cells during pigment
      biosynthesis].
AB  - A study was made of a possibility of incorporation of labeled amino acids into
      the composition of carotinoid pigment of the Staph. aureus. The use in the
      biosynthesis of Staph. aureus pigment of the following amino acids was
      demonstrated: valine, leucine, aspartate and glutamate. Carbon of amino acid
      radicals was mainly used in the carotinoid biosynthesis, this pointing to their
      preliminary decarboxylation by the corresponding decarboxylases of the bacterial
      cell.

PMID- 1015067
TI  - [Sensitizing properties of strains of stpahylococci differing in toxigenicity in
      the immediate hypersensitivity reaction].
AB  - The author presents the results of studies on the effect of staphylococcus toxin
      formation on the origination of allergic reaction. Staph. aureus strains, active
      producers of the alpha- and gamma-hemolysin, leukocidin, and Staph. epidermidis
      strains possessing no pathogenicity signs (a total of 8 strains) were used for
      the sensitization. Guinea pigs and rabbits served for the reproduction of
      anaphylactic shock and passive skin anaphylaxis after Ovary. Toxigenic properties
      of the strain were not the dominating factor in the formation of an allergic
      reaction of the organism. Immediate sensitization reaction occurred in the
      animals in response to the toxigenic and nontoxigenic strains not only after the
      administration of a reacting dose of homologous, but also of other strains of
      different toxigenicity. Sensitization reaction with Staph. aureus strains was
      more pronounced. Sensitization of the organism with Staph. epidermidis strains
      (possessing no pathogenicity signs) is also possible.

PMID- 1015068
TI  - [Modified nephelometric method of determining the activity of extracellular
      staphylococcal plasmocoagulase].
AB  - The nephelometric method of the quantitative determination of plasmocoagulase was
      modified. The medium for growing staphylococci and the composition of the
      "substrate" were elaborated. The necessity of recalculation of the absolute
      coagulase activity into specific activity with the consideration to the microbial
      cell count in the suspension from which the supernatent containing the enzyme was
      obtained. The greatest plasmocoagulase activity was revealed in the 6- and the 24
      hour cultures of Staph. aureus. The optimal time of incubation of the reactive
      medium (enzyme-substrate) was 4 hours.

PMID- 1015069
TI  - [Comparative study of mycoplasmae and stable L-forms of bacteria].
AB  - A comparative study of mycoplasmae and L-form bacteria was carried out. Both of
      them were well passaged on a special nutrient medium with the addition of
      thallium acetate, i.e. they were resistant to this factor. But, in difference
      from the L-form bacteria, mycoplasmae failed to be passaged on the serum-free
      medium; the cultures of the L-form bacteria were highly resistant to the action
      of osmotic stabilizers and to the pressure of the nutrient medium of 15 and 30
      atm; as to mycoplasmae--they perished at such a high pressure. The majority of
      mycoplasmae were resistant to the action of osmotic shock, and L-form bacteria
      lost their viability in distilled water as soon as in 2 hours.

PMID- 1015070
TI  - [Phenomenon of erythrocyte "spreading" on the surface of agar caused by hemolytic
      staphylococci].
AB  - Hemolytic staphylococcus was incubated at 37 degrees C in a Petri dish, on meat
      peptone agar with a layer of erythrocytes on its surface. Colonies surrounded by
      smaller radially-located secondary colonies of the same staphylococcus were
      revealed in 24 hours; there proved to be a direct relationship between the
      hemolytic activity of the staphylococcus and the size of the zone of erythrocyte
      "spreading". This phenomenon called the erythrocyte "spreading" phenomenon was
      caused only by hemolytic staphylococci. Apparently hemolytic staphylococcus
      secreted surfactants causing the "spreading" of erythrocytes from the growing
      colony.

PMID- 1015071
TI  - [Several aspects of the metabolism of bacteria grown on liquid nutrient media and
      subjected to freezing and thawing].

PMID- 1015072
TI  - [Isolation of bacteria of the genus Edwardsiella from patients with acute
      intestinal infections].

PMID- 1015073
TI  - [Toxicity and chemical characteristics of lipopolysaccharides of typhoid bacteria
      isolated from patients and carriers].

PMID- 1015074
TI  - [Immunologic structure of the population of several regions to Mycoplasma
      hominis].

PMID- 1015075
TI  - [Characteristics of the reactogenic and immunogenic properties of killed
      influence vaccine purified and concentrated by the method of adsorbed
      chromatography on silicate sorbents].
AB  - Reactogenic and immunogenic properties of killed influenza vaccine prepared of
      various strains of influenza virus by the method of sorption chromatography on
      sliciate sorbents were studied on small groups of volunteers; there proved to be
      a moderate reactogenic and a marked immunogenic activity of the experimental
      batches of the preparation. The dose, the concentration and the method of
      administration of the vaccine to obtain the immune response were determined. The
      indices of humoral and local immunity following a single vaccination were
      studied. On the basis of parenteral immunization of donors with killed influenza
      vaccine there were obtained experimental samples of the antinfluenza gamma
      globulin with an increased specific activity.

PMID- 1015076
TI  - [Epidemiologic effectiveness of anthrax vaccine STI].

PMID- 1015077
TI  - [Comparative study of the immunologic effectiveness of the oral and subcutaneous
      methods of administering pertussis vaccine].
AB  - The authors present the results of study of humoral immunity in rabbits after
      oral and subcutaneous immunization with pertussis vaccine. There was an increase
      in agglutinin titre and of the protective properties of the serum both after the
      oral administration of the vaccine according to two different schemes and after
      the subcutaneous immunization. However, rabbits immunized orally displayed a more
      prolonged (150-day) persistence of agglutinin titres, as well as of preventive
      and protective activity of the sera than rabbits immunized subcutaneoulsy.

PMID- 1015078
TI  - [Dynamics of DNA synthesis and blast cell reproduction during formation of the
      primary immune response and immunologic memory].
AB  - A study was made of the dynamics of the DNA synthesis and of the reproduction of
      the blast cells in the spleen by the methods of autoradiography and radiometry
      under conditions of a single intervenous immunization of CBA mice with high and
      low doses of sheep erythrocytes. In the formation of immunological memory
      stimulated by a subimmunizing dose of the antigen (1-10(5) erythrocytes) cell
      changes were observed almost exclusively in the periarterial zone; as to the
      primary response caused by a high dose of the antigen (1-10(9) erythrocytes), it
      was accompanied by the changes in the cell composition in all the zones of the
      spleen under study (periarterial, mantle, embryonic centres, red pulp). The
      maximal accretion of the blast count was observed in the both cases on the second
      day after the antigen administration. Dynamics of the specific intensity of the
      3H-thymidine incorporation into the tissues of the spleen showed the greatest
      correspondence with the dynamics of the cell changes in the periarterial zone of
      the spleen.

PMID- 1015079
TI  - [Character of the immune response in guinea pigs following immunization with
      brucellosis protective antigen].
AB  - In studying guinea pigs immunized with brucella protective antigen and the
      immunological response in them it was found that the antigen could be determined
      for 30 days by the method of fluorescent antibodies in the cells of the lymph
      nodes and the spleen following its intravenous injection. The optimal immunizing
      dose was 0.6 mg; in difference from a dose of 2 mg it produced an earlier and a
      more pronounced humoral effect. The phagocytic activity of the peritoneal
      macrophages of guinea pigs immunized with low doses was much more intensive than
      of those immunized with high doses of the antigen. Brucella protective antigen in
      a dose of 2 mg produced a disturbance of the carbohydrate metabolism in
      phagocytes, this influencing negatively their phagocytic function.

PMID- 1015080
TI  - [Avidity of specific antibodies in the sera of cholera patients  and vibrio
      carriers].
AB  - Avidity of specific antibodies was studied in the sera of patients suffering from
      cholera and vibrio-carriers by the rate of antibody binding (in the bacterial
      agglutination reaction) and by the completeness of their binding with O-antigen
      (in the passive hemagglutination test). There were revealed statistically
      significant higher indices of antibody avidity contained in the blood sera of the
      vibrio carriers, in comparison with the antibodies in the blood sera of patients
      with clinically manifest forms of cholera. There proved to be an increase in the
      antibody avidity in the dynamics of the infectious process. It is supposed that
      the degree of avidity of anticholera antibodies in examination of whole sera
      depended on the ratio of the specific macro- and microglobulins in them.

PMID- 1015081
TI  - [Changes in the surface structures of bacteria as a cause of weak immunogenicity
      of vaccines from several strains of Citrobacter].
AB  - The authors present the results of studying the weakly immunogenic Citrobacter
      strains; some O-antigens of Citrobacter (11, 14, 19, 21a, 21b, 26) caused in
      immunization of rabbits a weak immune response (antibody titre--1:400-1:800). An
      electron microscopic study of the vaccines (obtained from these strains) and
      their fragments showed that a partial desquamation and denaturing of the
      antigenic material occurred in the process of preparation of heated vaccines.
      Formalin-treated vaccine subjected to preliminary deflaggelation for 2 min at
      3000 cps was used for obtaining the O-sera against the mentioned antigens.

PMID- 1015082
TI  - [Effect of supplementary administration of microelements on antibody titers
      following immunization of animals with ADPT vaccine].

PMID- 1015083
TI  - [Encephalopathic syndrome in chronic non-specific lung diseases].
AB  - On the basis of a clinical, laboratory (blood gas content, function of external
      respiration, EEG, ECG eye ground, etc.) and pathomorphological studies the
      authors describe a syndrome of chronic lung encephalopathy in 34 patients with
      chronic nonspecific lung diseases (chronic pneumonia, chronic bronchitis). The
      report contains data on the development of chronic encephalopathy depending upon
      the severity of the basic disease. Treatment recommendations are given.

PMID- 1015084
TI  - [Neurologic pathology in severe forms of chronic renal failure].
AB  - The paper deals with the results of a neurological and psychological study of 162
      patients with chronic renal insufficiency. Among this contingent 122 were in a
      terminal phase and preserved a viability only because of a long-term (up to 4
      years) regular hemodialysis. The authors describe the dynamics of neurological
      pathology due to autointoxication and metabolic disturbances and suggest that the
      main foci of lesions are nonspecific structures of the mesencephalo-diencephalic
      brain areas and peripheral nerves on the background of a diffuse lesion of the
      nervous tissue.

PMID- 1015085
TI  - [Affection of the central and peripheral nervous systems in systemic lupus
      erythematosus].
AB  - Using the complex methods of morphological, neurohistological and histochemical
      methods in the study of the central and peripheral nervous system in systemic
      lupus erythematosus, the authors observed 20 patients who died at the age of 12
      56. The studies detected phenomena of disorganization of the connective tissue
      and vascular walls which are accompanied by a significant accumulation of
      muccopolysaccharides, thrombovasculites, endovasculites, lymphoid-plasmocellular
      infiltration and degenerative changes in the nervous elements.

PMID- 1015086
TI  - [State of the nervous system in psoriasis patients].
AB  - In order to clarify the role of the nervous system in the development of
      psoriasis the authors conducted a manifold dermato-neurological, biochemical and
      electrophysiological (EEG, REG) study of 130 patients. In 76.4% there were
      different neurological disorders: vegetative-vascular disturbances, functional
      diseases of the nervous system. Psoriasis was also seen in combination with
      segulae of brain injuries, neuroinfections, hypothalamic syndrome, vascular brain
      lesions, epilepsy. Clinico-electrophysiological studies detected a dysfunction on
      all levels of the brain, mainly in the limbico-reticular complex and
      mesodiencephalic formation. Quite possibly the above-mentioned changes are of
      significance for the development of psoriasis, making the use of drugs
      influencing these brain structure necessary. Taking into consideration the REG
      data it is also necessary to use preparations influencing the vascular tone of
      the brain and physiotherapeutical procedures normalizing the cerebral
      hemodynamics.

PMID- 1015087
TI  - [Autonomic paroxysms (of the stenocardia type) in vascular lesions primarily of
      the medio-basal portions of the temporal lobes of the brain].
AB  - In patients with vascular brain pathology the authors observed cases of temporal
      epilepsy in the clinical picture of which prevailed (and sometimes were isolated)
      vegetative-vascular "stenocardia" paroxysms. Such clinical states made it
      possible to suggest that in this contingent there was stenocardia proper.
      Stenocardiac paroxysms, due to cerebral pathology, were in combination with
      affective, mnestic and other psychopathological and neurological symptoms,
      indicating to an involvement into the vascular process of cortical
      representations of vegetative functions in the temporal area: hippocamp,
      amygdalar nucleus and their connections with the diencephalo-stem structures.

PMID- 1015088
TI  - [Pathology of higher cortical functions in patients with chronic respiratory
      insufficiency].

PMID- 1015089
TI  - [Odontologic and other etiologic factors in trigeminal neuralgia].
AB  - Trigeminal neuralgia may be due to many causes, being in this respect secondary.
      To a certain degree trigeminal neuralgia may be facilitated by an individual
      increase of reactivity in the trigeminal system to noxious factors. For this
      reason, in treating trigeminal neuralgia, it is necessary first of all to take
      into consideration the possible etiological factors including different diseases
      of the teeth, in the innervation of which an important role is played by the
      fibers of the trigeminal nerve.

PMID- 1015090
TI  - [Treatment of spondylogenic lumbosacral radiculitis with epidural novocaine
      hydrocortisone blockades].
AB  - The authors analyze some results in the treatment of 100 patients with
      spondilogenic sacro-lumbar radiculitis by epidural novocain-hydrocortisone
      blockades. The materials permit to substantiate indications, contraindications
      and some methodological approache in this form of treatment. In some cases
      epidural blockades were performed in combination with other forms of therapy
      (physiotherapeutical procedures, traction, analgetic drugs). A good therapeutic
      effect was seen in 88 patients.

PMID- 1015091
TI  - [Phenomenon of cerebrospinal fluid lymphocyte blast-transformation in several
      inflammatory diseases of the nervous system].
AB  - Morphological and autoradiographical studies of leukocyte cultures of the CSF in
      20 patients with serous meningoencephalitis of a diverse etiology permitted the
      authors to establish the following condition. There is a phenomenon of lymphocyte
      blastransformation under the influence of phytohemagglutinine (PHA) and
      tuberculin. These data made it possible to suppose of the existence of T2
      lymphocytes in the CSF. A correlation between the obtained data and the clinical
      picture demonstrated that 30-50% of the lymphocytes respond to PHA, irrespective
      of the etiology of meningoencephalitis, while blasttransformation to tuberculin
      occurs only in tuberculous meningoencephalitis. The authors attribute an
      important practical role to these findings for a differential diagnosis between
      obliviated forms of tuberculous meningoencephalitis and serous
      meningoencephalitis of a nontuberculous origin. These data give ground to assume
      that the CSF and the lymphocytes circulating in it form a strong immunological
      "mobile" barrier to the brain.

PMID- 1015092
TI  - [Oscillographic speech recording as a method of differential diagnosis of
      different forms of dysarthria].
AB  - In order to differentiate paralytic, cerebellar and extrapyramidal forms of
      dysarthria the authors used the method of oscillography of speech in 20 normal
      and 30 patients. It was established that as differential diagnostical
      oscillographic criteria such phenomena as disorders of articulation, the latent
      period, role of speech, duration in the pronounciation of separate elements of
      speech, the correlation of the duration of words and pauses, amplitude of
      fluctuations and "oscillogrpahic intonation" of speech can be used.

PMID- 1015093
TI  - [Innervation of the medial group of plantar muscles in man (electrophysiologic
      study)].
AB  - The central response of the medical group of muscles in the foot sole, as a
      reaction to a stimulation of the tibial nerve has an antidrome character in
      normals over 20-22 years of age. However, in children and adolescents, as well as
      in disturbance of the supra-segmental control in this sort of response is a
      prevalent reflectory (monosynaptical) component. A similar trait was found in
      patients with discogenic radiculitis in an isolated lesion of the L5 radicle. And
      on the contrary, a pathology of the S1 radicle not only did not change the
      antidrome character of the response, but prevented the dominance of the
      reflectory component in cases of an accompanying lesion of the descending spinal
      conductors or L5 radical. The conclusion is made that the innervation of the
      protuberant muscles of the 1 finger in the human foot is accomplished by the L
      motoneurons of the anterior horns of the S1 segment.

PMID- 1015094
TI  - [Several aspects of the problem of psychopathy and prospects for scientific
      research in that area].
AB  - The author rises some problems of psychopathy which are the most significant at
      present: etiology and pathogenesis of psychopathy, their clinical classification,
      studies of their dynamics, differentiation of psychopathy from other forms of
      borderline conditions. In respect to the data concerning the modern state of the
      studies in psychopathy new perspectives in this area emerge: epidemiological
      studies of psychopathy, a study of its biological substrate, a creation of a
      unified classification of psychopathy, a differentiation of separate forms in the
      dynamics of psychopathy.

PMID- 1015095
TI  - [Mechanisms of disorders in the assessment of external signals in psychopathies].
AB  - The author discusses some results of studies in evoked brain potentials of
      excitative and inhibitive psychopathic personalities. The evoked brain potentials
      to signal significant stimula in psychopaties are changed these changes being
      different in the groups of excitative and inhibitive psychopaths. In psychopathic
      personalities the amplitude changes to a significant stimula, not so much of the
      late but of the early components of response. The changes of early waves in the
      excitative and inhibited groups are differently directed. It can be supposed that
      these changes reflect the disturbances in the informational brain processes in
      psychopathic personalities which can be most distinctly seen in emotionally
      significant situation.

PMID- 1015096
TI  - [Differences in serotonin and dopamine metabolism in psychopathy and sluggish
      schizophrenia].
AB  - The studies established some differences in the serotonin metabolism in
      psychopaths and in patients with sluggish schizophrenia (261+/-9 ng/ml and 329+/
      7 ng/ml of whole blood respectively). A comparison of the homovanilin acid
      content in the blood serum of patients in both groups (normals -62.1+/-9.3 ng/ml,
      psychopathic personalities -86.0+/-10.1 ng/ml, schizophrenic patients -34.5+/-8.6
      ng/ml) points to a tendency towards an intensification of the dopamine metabolism
      in patients with psychopathy and a drop in the intensity of dopamine metabolism
      in schizophrenic patients.

PMID- 1015097
TI  - [Critical capabilities in psychopathics].
AB  - The authors studied the capabilities of psychopathic personalities (58 cases) to
      control their behaviour by involving such factors as the past experience, the
      existing knowledge selfestimation, the level of pretension. The results of such
      studies established insufficiency of controlling the activities in using the past
      experience, inadequate selfestimation and level of pretension, incapability to a
      prognosis of the aftereffects of personal actions. These disturbances may
      determine the disturbances of critical capabilities in psychopathy.

PMID- 1015098
TI  - [Personality structure mosaicism as a stage in the development of psychopathies].
AB  - An appliance of the principle of dynamics in relation to studies of psychopathy
      (164 cases) permitted to detect the periods of mosaicity in their formation and
      subsequent development. The authors describe some polymorphic phenomena in the
      clinical picture during the first period (complexity of the
      pathocharacterological structure, neurotic signs, the traits of the affective
      pathology, etc.). It was also possible to speak of some aging limits in the
      period of mosaicity and to demonstrate dependence of the clinical content on the
      genetical or clinical type of psychopathy. The report contains some differential
      diagnostical criteria or psychopathy of this age stage with psychopath-like
      conditions of a schizophrenic or organic genesis. Some main recommendations are
      given for a forensic-psychiatric evaluation of the described states.

PMID- 1015099
TI  - [Clinical dynamics of several constitutional psychopathies during the period of
      their development].
AB  - The authors outline the main regularities in the dynamics of the formation of
      constitutional psychopathy in childhood and adolescence on the models of
      epileptoid and schizoid psychopathy. Some age traits of psychopathical and
      psychogenic reactions and their role in the formation of constitutional
      psychopathy are discussed. The period of their formation is considered as
      psychopathic development, due to a complex interaction of constitutional
      anomalies of temperament, instincts and drives with the micro-socio-psychological
      environment.

PMID- 1015100
TI  - [Clinical dynamics of hysterical psychopathy].
AB  - The report contains materials of a long-term clinico-catamnestical and social
      psychological study of 136 patients with hysterical psychopathy. The main stages
      of a formation of psychopathy in 3 genetical subgroups ("nuclear", "borderline"
      and organic) were studied. The authors conducted a typological analysis of
      hysterical psychopathic personality with an elimination of "obligatory" and
      "optional" symptoms. Some regularities in the aging dynamics of hysterical
      psychopathy are given in respect to 3 periods: childhood and adolescency;
      mature:old age.

PMID- 1015101
TI  - [Clinical basis for a differentiated approach to psychopathic personality
      adaptation].
AB  - In the process of compensation of psychopathy there is a complex reformation of
      its structure due to the development of secondary compensatory personality
      changes on the background of primary pathocharacteriological personality traits.
      However, each form of psychopathy maintains its specific clinical symptoms which
      should be taken into consideration in a goal-directed formation of conditions,
      facilitating an adaptation of such patients. Consideration of specific traits in
      the structure of psychopathy and the reaction of patients to different factors
      allows one to select conditions where the requirements to the "weak" side of the
      personality would be reduced, while its relatively "strong" sides were applied
      productively.

PMID- 1015102
TI  - [Interaction of external and internal factors in the manifestations and formation
      of psychopathies and pathological personality development].
AB  - The authors substantiate the concept that the material and pathophysiological
      substrate of psychopathy is the pathological variant of the highest nervous
      activity type, on the basis of which psychopathy appears and begins to form. They
      attempt to answer some questions concerning the correlation between exogenous and
      endogenous origins of psychopathy. A delineation between psychopathy and normal
      variants on the one hand and accentuated personalities and pathocharacterological
      personality development on the other one is made.

PMID- 1015103
TI  - [Characteristics of psycho-traumatic situations in the clinical picture of
      psychogenic reactions].
AB  - On the basis of a clinico-psychopathological study of 90 patients with the most
      frequently encountered forms of reactive conditions, the author eliminates the
      predilective clinical types of psychotraumatizing situations. The appearance of
      reactive depressions and neurasthenia is connected with stress situations and
      exhaustions. Obsessional neurotic states are connected with situations of
      disturbed habitual stereotypes while as hysteric states--with situations of
      infringement of egocentrism. Paranoical reactions appear in situations of a
      denial incompromissity.

PMID- 1015104
TI  - [Development of psychogenic depression in middle age].

PMID- 1015105
TI  - [Assessment of the effectiveness of autogenic training in the complex treatment
      of neurotic and psychopathic states].
AB  - An examination of 68 patients with neurotic and psychopathic states detected the
      existence of significant connections between the method of treatment and reverse
      development of the symptomatology. The author used sets clinical scales and
      methods of statistical canonic, regressional and dispersional analysis. The most
      effective appeared to be autogenic training and aminazine. The effectiveness of
      aminazine was most distinctly seen in arresting hysterical characterological
      disturbances. The action of autogenic training in combination with amytriptiline
      was more effective in the treatment of insomnia and psychopathic disorders of the
      inhibitive type.

PMID- 1015106
TI  - [Role of V. Kh. Kandinskii in the development of Soviet forensic psychiatry].

PMID- 1015107
TI  - [Reproduction of a given frequency of rhythmic movements in lesions of different
      motor formations].
AB  - By means of the tapping method the authors studied the capability of reproducting
      induced paces of rhythmical movements in 22 patients with the localization of the
      pathological process in subcortical nodes and in the brain stem. The induction of
      temporary programmes was accomplished by an electrophotostimulator, while the
      tapping registration--by an electromyo- and electroencephalographic method. It
      was demonstrated that in parkinsonic patients the most successful reproduction
      was accomplished in a pace of 6 hz. In cortical lesion there was a tendency to
      slow pace (1-2 hz), to a perseveration of made mistakes and a difficulty in
      transmitting from one pace to another. In stem lesions there was a disturbance in
      the reproduction of paces in all series of the experiment. The authors discuss
      the hypothesis of an existence of endogenous temporary programmes as an
      independent neurophysiological factor. It is being assumed that a study of the
      influence of external rhythmical signals on the internal (endogenous) time may
      have a decisive importance for special methods of rehabilitation of motor
      functions.

PMID- 1015108
TI  - [Bioelectric activity of paravertebral muscles in experimental scoliosis].
AB  - The paper is concerned with a study of the bioelectrical activity of the
      paravertebral muscles in 2 groups of rabbits with differently expressed degrees
      of experimental scoliosis and in a control group of intact animals. The results
      demonstrated an asymmetry in the tonic bioelectric activity in the paravertebral
      muscles in scoliosis, unlike the reactions of the control group of animals. The
      character of asymmetry depends upon the degree of deformation: in cases of
      moderately expressed scoliosis there is a prevalence of the tonic bioelectric
      activity on the level of the basic arc of distortion on the side of the
      concavity; in severely expressed scoliosis the tonic bioelectrical activity of
      the paravertebral muscles on the concave side appears to be less than on the
      convex side. An asymmetry of the tonic activity takes place on the level of
      compensatory arcs as well. The authors come to the conclusion on the
      pathogenetical role of the muscular dysbalance in the genesis of scoliotic
      deformation.

PMID- 1015109
TI  - [Spectral analysis of the EEG in patients with cerebral contusions and traumatic
      intracranial hematomas].
AB  - The authors subjected to a mathematical analysis 80 electroencephalograms
      registered in 20 patients with contusional foci andintracranial hematomas,
      verified during surgical operations. In order to evaluate the peculiarities of
      the EEG spectrograms an adaptive system of filtration was proposed which was
      based on an approximation of the assessment of the spectral density. The used
      method with the aid of computers permitted to detect the characteristic
      disturbances of the frequency spectrum in the EEG which had a topical and
      differential diagnostical significance for patients in the acute period of a
      severe brain injury.

PMID- 1015110
TI  - [Effect of alcohol abuse on the development and course of acute cerebral
      circulatory disorders].
AB  - A study of 544 patients with acute disorders of cerebral circulation demonstrated
      a correlation between the development of a stroke and the degree of alcohol
      abuse. In patients who abused alcoholic beverages acute disorders of cerebral
      circulation developed at a younger age, were much more acute and more frequently
      had a lethal outcome, especially if the stroke developed during acute alcoholic
      intoxication. The study also showed that in such cases hemorrhagical strokes were
      more common than ischemic.

PMID- 1015111
TI  - [Effect of dexamethasone on indices of cerebral circulation].
AB  - With the aid of a REG method the authors studied the effect of dexametasone on
      the cerebral hemodynamics in 37 patients with cerebral atherosclerosis with
      chronic cerebrovascular insufficiency. It was possible to show that there is an
      accelerated venous blood outflow, a decreased vascular resistance, as well as the
      absence of a vasopressor reaction to a single intravenous administration of 4 mg
      of dexametasone. The capability of the preparation to reduce the volume of
      cerebral pulse waves limits its use in the initial decreased amplitude of
      cerebral pulse fluctuations.

PMID- 1015112
TI  - [Lability of the temperature analyzer in neurologic clinical practice].
AB  - With the aid of thermopulsation the authors determined the maximal frequencies of
      separately percepted thermal stimula in the different areas of the skin surface
      (lability of the thermal analyzer). Such studies were performed in normals and in
      patients with organic brain and spinal lesions. It was established that in
      pathological conditions changes of lability go far beyond the limits of
      corresponding morphological changes and demonstrate distributed neurodynamical
      shifts. These data are considered from the standpoint of extralemniscal disorders
      of general sensitivity.

PMID- 1015113
TI  - [Mnestic disorders in tumors of the temporal lobe].
AB  - The paper contains some results of a neuropsychological study of memory in 32
      patients with tumors of the temporal lobe. The authors distinguished syndromes of
      disturbed speech memory (mainly--auditory-verbal) in tumors of the medial,
      posterior and, to a less degree, frontal areas of the left temporal lobe. In
      tumors of the right temporal lobe changes of memory were less expressed and had
      prevalently a visual-image character. An involvement into the process of the
      hyppocampus leads to a model nonspecific drop of short-time memory, while the
      expansion of the tumor towards the diencephalo-mesencephalic structures--to a
      formation of the Korsakoff syndrome. The results of the study demonstrate a
      certain correlation of disturbed memory with degree of emotional changes. It is
      being assumed that the defect of a retarded reproduction is due to an inertia of
      the nervous processes.

PMID- 1015114
TI  - [Speech disorders in tumors of the left frontal lobe].
AB  - The paper deals with a description of speech activity or dynamic aphasia seen in
      9 patients with tumors of the left frontal lobe. A weakening of volition to
      speech was combined with disorders of naming, verbal memory, logic thinking. All
      these disturbances were accompanied by general motor inhibition. Among the 9
      studied patients in 8 cases the focus of lesion was situated on the medial
      surface of the hemisphere, corresponding to the supplementary Penfield speech
      zone.

PMID- 1015115
TI  - [Combined treatment of Parkinsonism with levopa, midantan and anticholinergic
      drugs].
AB  - For the treatment of 42 patients with different forms of atherosclerotic and
      postencephalitic parkinsonism the author used levopa drugs, medantane, cyclodol
      and parkopan in combination and separately. The most stable improvement was
      obtained from a combination of levopa with cyclodol in patient with rigid
      akynetic-trembling manifestations of parkinsonism. The treatment by medantane
      increased the therapeutical effect in the patients with postencephalitic
      parkinsonism. Methyl-dopa and pyridoxine served as a corrector of levopa. The
      studies on the blood content of acetylcholine and cholinesterase showed a growth
      of cholinolytic and cholinesterase activity in the blood.

PMID- 1015116
TI  - [Serotonin concentration in the blood of patients with tonic seizures localized
      in the brain stem].
AB  - The authors studied the content of general serotonin in different periods of
      attacks in patients with tonic attacks of a stem localization. It was possible to
      demonstrate an increased content of blood serotonin in the initial phase of the
      attack. During the crucial phase the serotonin content compared to the initial
      phase, decreases. However, its level compared to the onset level continued to be
      high. An increase in the serotonin content was accompanied by significant
      neurotic symptoms and in some cases by psychomotor excitation. The spectrograms
      of serotonin eliminated from the blood of patients are different by forms and may
      serve as one of the tests for the establishment of the degree of the disorder.

PMID- 1015117
TI  - [Several biochemical signs of loss and restoration of visual function].
AB  - With the aid of cytophotometry the author studied the cellular chemistry of
      neurons (according to the activity of glutamate dehydrogenase) in the III, IV and
      V layers of the visual cortex in rats during the period of rehabilitation of
      specific functions following long-term light deprivation. It was demonstrated
      that a 2-week stay of deprivated animals in conditions of usual light is
      accompanied by visible normalization of the glutamate dehydrogenase activity in
      the cortical neurons. However, a complete rehabilitation of the control level was
      not attained. The study demonstrated differences in the reactions of identical
      neurons in the IV and V layers to the rehabilitation of specific functions. It is
      being assumed that the rehabilitation of the visual function may be due to
      biochemical reconstructions in the monomodel and certain parts of the polymodal
      neurons in the visual cortex.

PMID- 1015118
TI  - [Psychological features of the level of pretension in goal choice in
      psychopathy].

PMID- 1015119
TI  - [Relationship between perception of facial expression by schizophrenic patients
      and disorders in their assessment of probability].
AB  - The author proposes a method of studying some traits of mimic perception where an
      oral report is avoided. The essence of the method is in a distribution by the
      examine of a series of photographs of the same face into such groups so as to
      have similar facial expressions. The experiments demonstrated that such
      distributions are mainly performed on a direct intuitive level. The examinee is
      given several series of photographs of different faces. In an evaluation of the
      results the probability of different combinations attained in a group of normals
      are being considered. The author compared a group of schizophrenic patients (60
      cases) and a group of normals (100 cases). The patients significantly more
      frequently (p less than 0.001) give combinations of photographs with a low
      probability 0.01-0.05. The preliminary data indicate that this trait correlates
      with the severity of the clinical picture. Among the normals 7% of the examined
      individuals gave a stable high amount of answers with a low probability. This
      group of individuals detected characterological peculiarities reflected in the
      questionnaire. It may be assumed that this trait in the evaluation of mimics is
      due to a constitutional and morbid process.

PMID- 1015120
TI  - [Comparative study of thought characteristics of adolescents healthy and
      schizophrenic].
AB  - The paper is concerned with selectivity formation in the actulization of
      knowledge during the process of thinking in cases of abnormal development of
      adolescents--schizophrenic patients (61 cases). The study was performed in
      contrast to a control group of normals (114 cases) of the same age and
      educational census. The results demonstrate changes in the process of selectivity
      formation in the actualization of knowledge in adolescent schizophrenic patients
      which was detected in a weakening of the organizing role of the adopting system
      of social experience during the development of the cognitive activity.

PMID- 1015121
TI  - [Schizophrenic and schizophrenic-like manifestations in syndrome 47, XYY].
AB  - The authors examined 4446 patients in mental hospitals. Among these patients 15
      displayed the 47 XYY syndrome and 3 with mosaicism 46 XY/47 XYY. A study of these
      patients showed that in 5 cases they were qualified as schizophrenic. They were
      study died from 2-5 years. In 4 cases the diagnosis of schizophrenia was not
      confirmed. In one case the authors diagnosed the disease as an atypical form of
      schizophrenia. The clinical traits of the disease in this case are associated
      with a supplementary Y somasomia.

PMID- 1015122
TI  - [Development of circularity as a manifestation of schizophrenic pathomorphosis].
AB  - On the basis of literature data and personal experience the author indicates the
      pathomorphosis of schizophrenia towards its circularization. It is claimed that
      this phenomenon cannot be explained entirely by the use of psychotropic drugs. A
      study of the reasons of such "nontherapeutical" pathomorphosis requires special
      studies. A necessary condition for such studies is a clear selection of clinical
      material. In this relation the author proposes to base such studies on the origin
      of cyclothymic disorders which may stem from typological traits of the circular
      form, or from a predisposition to vital-affective registers in the premorbid
      personality or developed in the process of schizophrenia. Some clinical features
      of the disease connected with affective pathology are discussed.

PMID- 1015123
TI  - [One of the variants of lucid catatonia with long-term remissions].
AB  - The presentation concerns 10 observations of lucid catatonia and protracted
      remission. Among the group of schizophrenia these cases constitute only 0.8% of
      all cases. They are characterized by a prevalence of negative signs and catatonic
      disorders which can be alloted to the anergic pole and are seen during the entire
      development of the disease. The most striking feature of such cases is their
      "outpatient" development of the process. The protracted remissions (15-37 years)
      are characterized by an expressed defect without positive symptoms.

PMID- 1015124
TI  - [Rehabilitation of schizophrenic patients with a protracted course under usual
      industrial conditions].
AB  - The authors studied the effectively of rehabilitation in 220 patients with a
      protracted course of the schizophrenic process in individually created
      conditions, at a usual industrial plant and in conditions of state farms. The
      clinical observations and dispersed analysis detected that there are multifold
      correlations between different clinical factors and the effectiveness of
      rehabilitation. The authors have their opinion concerning the necessity of
      elaborating differentiated clinical indications to the rehabilitation of
      schizophrenic patients with a prologned continuous stay in a hospital. According
      to 2-year following up the general outcome of rehabilitation was evaluated as
      favourable in 69%. These data permit to expand the present concept of the
      clinical and social prognosis in protracted forms of schizophrenia.

PMID- 1015125
TI  - [Clinico-psychopathologic characteristics of schizophrenic patients who have
      performed socially dangerous acts (comparative epidemiological findings)].
AB  - A statistical analysis of a multifactorial comparative epidemiological study of
      schizophrenic patients performing and not performing dangerous actions during the
      period of the disease detected the following: psychological signs of
      schizophrenia were significantly more frequently seen at different stages of the
      disease in these patients who performed dangerous acts. There was a certain
      correlation between specific clinical signs and the age and sex structure,
      "prepsychotic" personality properties, exogenous influences. It was also possible
      to demonstrate a certain correlation between the frequency of dangerous acts and
      clinical conditions.

PMID- 1015126
TI  - [Reproduction among the mentally ill].
AB  - The authors conducted a comparative analysis of the reproductiveness fertility
      and familial position of 2035 mental patients and 5358 normal females. It was
      possible to demonstrate a general drop during the past several years in the
      fertility, especially in the patients. The index of fertility and brutto
      coefficient of reproductiveness in the group of patients is equal to 30-70% from
      the level of normal reproductiveness. However, in some forms of pathology (in
      patients with periodic schizophrenia) the level of reproductiveness falls more
      slowly than in the general population. It has been established that more than
      half of the children of schizophrenic patients (50.9%) are born after the onset
      of the disease. The level of fertility and the number of children or normals
      depends upon social factors (educational census, family budget). In mental
      patients these indices depend upon the degree of malignancy and the age of the
      onset of the pathological process.

PMID- 1015127
TI  - [Role of the age factor in forming the clinical picture of anorexia nervosa].
AB  - The results of long-term clinical and experimental-psychological studies of
      patients with nervous anorexia were analyzed from the point of view of age
      psychology. Such approaches permitted to distinguish a peculiarity in the
      formation mechanism of this form of pathology. Dynamical studies of the moving
      forces in the personality development in morbid conditions allowed one to
      distinguish certain disorders in the process of periodization of the mental
      development. This in its turn exerts influence on the development of nervous
      anorexia.

PMID- 1015128
TI  - ["Lunar rhythms" in the course of the epileptic process].
AB  - On the basis of a mathematical analysis of 8400 seizures during 101 moon phases
      it was possible to establish a correlation between the frequency of convulsive
      paroxysms (both in the amount of seizures in epeileptic patients and amount of
      patients in whom these seizures appeared) and the phasic position of the Moon-
      periods of a full moon and new moon. The amount of patients and seizures
      increased during the periods of such phases 1.52 and 1.56 times corresponding
      more in comparison to the median significance of these figures. A study of the
      role of physical ressons of a wave and magnetic nature on the development of the
      epileptic process may help to understand the pathogenetical mechanisms of the
      disorder.

PMID- 1015129
TI  - [Hereditary crossed palpebro-palpebral synkinesia].
AB  - The author describes 3 variants of involuntary -- synkinetic movements of the
      eyelid seen in 36 among the 250 examined patients. A study of the genealogy
      demonstrated a hereditary nature of this abnormality. In most of the cases the
      inheritance was of the auto-some-dominant type. Inasmuch as there is a regular
      combination of hereditary crossed palpebro-palpebral synkinesis with inborn signs
      of stem structure insufficiency the importance of such synkinesis for the
      differentiation of inborn and acquired microorganic symptomatology is stressed.

PMID- 1015130
TI  - [Clinico-electromyographic characteristics of piriform muscle syndromes].
AB  - The report is concerned with the screening methods of lesions of the piriformis
      muscle in the piriformis syndrome which is more frequently connected with sacral
      osteochondrosis. However, this syndrome may sometimes appear in an ankylosis of
      the hip joint. All the diagnostical methods may be divided into 3 groups:
      indirect clinical method, palpation and EMG. The first method does not require
      special experience. A palpation of the piriformis muscle is conducted bimanually
      by a method proposed by the authors. EMG studies with the aid of needle
      electrodes permit to distinguish spasms and more crude changes in the piriform
      muscle.

PMID- 1015131
TI  - [Dynamics of neurologic disorders following embolism of the bifurcation of the
      aorta and major arteries of the lower extremities].
AB  - The authors conducted a clinico-EMG study of 118 patients with an embolism of the
      aortal bifurcation and magistral arteries of the lower extremities. Among this
      contingent 58 were studied in the remote period -- from 2-7 years following a
      surgical operation. The clinical symptoms of embolism were expressed in severe
      pain, sensory, motor and vegetative-trophic disturbances in the affected
      extremities. Three degrees of the nervous system lesions were distinguished in an
      embolism. It was also demonstrated that there were significant changes in the
      bioelectrical muscle activity of the extremities. In the remote period following
      embolectomia, in most of the patients there still were sequalae of acute ischemia
      of the nervous tissue, the expressiveness of which depended upon the calibre of
      the occluded vessel, degree of tissue ischemia, the time of treatment and the
      time following the operation. A retarded restitution may be explained by the
      degree of the nervous tissue lesion and the persisting insufficiency of
      circulation in the extremities.

PMID- 1015132
TI  - [Fahr's disease (idiopathic non-atherosclerotic calcification of the cerebral
      arteries)].
AB  - The authors describe one case of Fahr's disease in a 69-year-old male. The
      disease was characterized by a rapid development with polymorphic subcortical
      symptoms (mainly hyperkinetic) and a rapid disintegration of intellectual
      functions. Besides that, cortical and pyramidal disturbances (hemiparesis, visual
      disorders, etc.) were also marked. In the postmortem examination selective
      calcifed cerebral vessels were found, typical for this form of the disease. This
      observation gave no supplementary data on the etiology of the disease. Laboratory
      data did not depict any deviation from the norm.

PMID- 1015133
TI  - [Early diagnosis, early therapy and prognosis of epidemic cerebrospinal
      meningitis].
AB  - The authors convened a special study for purposes of determining early signs of
      epidemic cerebrospinal meningitis and for the dependence of the prognosis from
      early etiotropic and pathogenetic therapy. On the basis of a study of 93 cases
      criteria of early diagnosis are being given. Unlike the data in literature, in
      60.2% of the cases it was possible to initiate treatment during the first hours
      of the disease and in 94.6% -- not later than 48 hours. In most of the cases the
      disease had a grave course. Changed consciousness was observed in 55.9%, an
      increased amount of protein in the CSF -- in 58%. In 8 cases there was a syndrome
      of acute renal insufficiency. Despite these facts all the patients recovered. The
      authors come to the conclusion that prognosis may be significantly improved in
      cases of early diagnosis (during the first hours), intensive penicillin therapy
      (both intravenously and kanamicin into the carotid artery). The authors suggest
      that during reconvalescence it is feasible to prescribe resolving (pyrogenal
      lydase) and general therapy.

PMID- 1015134
TI  - [Intensive therapy of herpes zoster with deoxyribonuclease].

PMID- 1015135
TI  - [Use of glucocorticoid hormones in multiple sclerosis].
AB  - A long-term observation over patients with disseminated scleosis who were treated
      by glucorticoid hormones demonstrated that hormone therapy with short sessions
      and a standard scheme appeared to be uneffective. The presentation is based on an
      examination of 25 patients who had undergone a durative course of hormone therapy
      with an individual scheme of optimal doses equal to middle ones (30-40 mg of
      prednisolon) and a selection of maintenance doses used for a long time or with
      short intervals. Such forms of treatment were more effective. During treatment
      the authors used immunological tests and analysis of electrolytes in the blood,
      sugar, urea, etc. Hormone therapy is indicated in acute forms of disseminated
      sclerosis and in a remittent development in the stage of exacerbation in the II
      and III phases. Along with favourable effects in 3 patients there was a
      development of hormone dependency and complications.

PMID- 1015136
TI  - [Catecholamine excretion and treatment of parkinsonism with midantan].

PMID- 1015137
TI  - [Treatment of spastic torticollis with phenol-glycerin and alcohol-novocaine
      blockade].
AB  - Among the different etiological factors of spastic torticollis the authors
      attribute the main role to the gamma-motor system. They have elaborated a
      treatment method which blocks the neuromotor points of the gamma-motor system in
      the sternocleidomastoid and Musculus trapesius muscle by alcoholnovocain or
      phenolglycerine. Treatment was administered to 44 patients from 17-67 years with
      etiologically different diseases. A significant improvement was marked in 11
      patients, improvement in 28. The absence of a positive effect was seen in
      patients with torsion dystonia. Clinico-EMG data demonstrated that influence on
      the peripheral segment of the reflectory are which is involved in the phasic
      tonic muscle reactions, by a differentiated focal disengagement of gamma-motor
      mechanism facilitates a removal of spasticity and a restitution of a normal tonic
      and motor activity in the muscles of the neck.

PMID- 1015138
TI  - [Treatment of patients with different forms of myotonia with diphenin and
      novocainamide].
AB  - Patients with different forms of myotonia were treated by 2 preparations:
      novocainamide and Diphenine (diphenylhydantoin). Patients with Thomsen's myotonia
      (9 cases) and with atrophic myotonia (7 cases) were treated by novocainamide with
      a daily dosage of 0.75-1.5 gm during 3 weeks. A decrease of the myotonical
      contracture was more marked in patients with Thomsen's myotonia and was arrested
      following 2-3 days after its discontinuation. Treatment of patients with atrophic
      myotonic by novocaiamide was not feasible inasmuch as there were some
      contraindications for its use. In 9 cases of Thomsen's myotonia and in 5 with
      atrophic myotonia treatment was given by diphenine in daily dosages from 0.4-0.5
      gm during 4 weeks. In 6 patients with Thomsen's myotonia and in 3 cases of
      atrophic myotonia there was a significant improvement. In 2 cases diphenine even
      in minimal doses lead to allergic reactions. No effect was marked in 3 cases.
      Diphenine appears to be effective in Thomsen's myotonia and in patients with
      atrophic myotonia with insignificant muscular atrophy. The effect after treatment
      lasted up to 4 weeks.

PMID- 1015139
TI  - [Medical rehabilitation medical-disability expertise of patients with post
      traumatic bone defect of the skull].
AB  - The authors analyzed the results of treating 171 patients with sequelae of brain
      trauma and defects in the bones of the cranial fornix. On the basis of repeated
      examinations disturbances of brain functions were detected in 94 patients. In the
      remaining cases the only reason for invalidity was the cranial bone defect. For
      purposes of cranioplasty different methods were used. The results of surgical
      treatment permit to claim that the operation of choice in closing the bone defect
      is cranioplasty by homobones. In alloplasty of the cranial bone defect and all
      the more so in homobone plasty, it is expedient to reconsider the medico-labour
      examination in this category of patients.

PMID- 1015140
TI  - [Clinical manifestations of the local effect of protons with an energy of 1000
      Mev following irradiation of the hypophysis (experimental)].
AB  - In order to study the clinical picture due to inrradiation of the hypophysis by
      protons with an energy of 1000 Mev with the use of a pendulum technique, the
      authors examined 30 dogs including 27 with an irradiated hypophysis and 3 control
      animals during 2 years. The results were verified in autopsies and in
      histological studies. These examinations demonstrated frequent general cerebral
      symptoms, focal neurological and hypophysis-endocrinological symptoms as well as
      frequent lesions of the cranial nerves, epileptic seizures and nonsymptomatic
      focal brain necrosis. It was also possible to demonstrate a correlation of the
      clinical traits with the dosage of the irradiation and the time past after
      irradiation. The report contains corrections for using these data on humans.

PMID- 1015141
TI  - [Progressive course of the sequelae of closed cranio-cerebral trauma at remote
      periods (in relation to the test of rehabilitating invalids from the Second World
      War)].
AB  - On the basis of modern knowledge of the clinical picture, pathophysiology and
      pathomorphology of the residual period of brain injuries and a study of 140
      cases, examined in the Central Institute for Expertise of Working Capacity the
      author discusses some clinical characteristic of the remote sequelae of brain
      injuries received during the war and the possible variants of their pathogenesis.
      A comprehensive clinical study of such patients with the use of paraclinical
      methods (EEG, REG) permitted to establish a cerebro-vascular nature of these
      disorders with a development of vasopathy, traumatical hypertension, early
      vascular involution with a transition to early cerebral atherosclerosis. Having
      this in view the author considers some problems of the causal connections of
      these disorders with injuries and concussions received at war.

PMID- 1015142
TI  - [Pathologic hypochondriacal personality development (conditions of formation,
      clinical variants, type of course)].
AB  - The paper deals with some results of a complex somato-psycho-neurological study
      of 51 patients with a pathological hypochondriacal personality development which
      led to a stable restriction or a complete loss of working capacity. The author
      indicates a complex pathogenesis of this disorder: a low level of socio-working
      adaptation and psychopathic traits in the premorbid personality; psycho
      traumatizing situation due to an underestimation by the physicians of the
      severity of the somato-neurological disorder which in some cases is supplemented
      by an unfavourable family situation.

PMID- 1015143
TI  - [Organization of dynamic observation of alcoholics and addicts under conditions
      of the out-patient department of a narcologic hospital].

PMID- 1015144
TI  - [Prognosis of juvenile schizophrenia with dysmorphophobic disorders (according to
      catamnestic findings)].
AB  - On the basis of clinico-catamnestical studies of 72 patients with adolescen
      schizophrenia and dysmorphophobic disturbances the author distinguished 3
      variants of the outcome of such conditions. The clinical picture was in
      correlation with the degree of progressiveness of the disease and the type of
      development. Some prognostic criteria concerning the development of the disease
      are given. In favour of a relatively favourable prognosis of dysmorphophobic
      conditions spoke the following phenomena: a monothematical character of
      dysmorphophobia, its nondelusional state, the absence of focal cenesthopathy and
      olfactorial hallucinations, a proximity of the content of dysmorphophobia to
      pubertal psychological signs, a connection between the exacerbation periods with
      depressive states, an undulating charcter of dysmorphophobic symptoms during
      adolescence and the oneset of the disease with psycheastheno-like disturbances.
      An unfavourable prognosis was characterized by a delusional character of
      dysmorphophobic disturbances, bizzare delusional hypochondric systems, including
      dysmorphophobia, ideas of reference, cenesthopathy, tactile and olfactory
      hallucinations, an insignificant dependence of dysmorphophobia from affective
      disorders and early appearing distinct personality changes.

PMID- 1015145
TI  - [Long-term stable remissions in slowly progressive juvenile schizophrenia].
AB  - Protracted stable remissions without residual psychotic disorders are not
      homogenous while as their typology to a great extent depends upon the clinical
      picture of the previous attack and the differences in the structure and degree of
      negative changes. The most stable remissions appeared to be those where the
      negative disorders did not go beyond the pathological personality changes
      (pseudopsychopathic states) which by their structure were similar to the
      expansive pole of schizoid psychopathy. After more polymorphic attacks the
      remissions had a more deep register of negative disturbances, with signs of a
      sluggish development, increasing the probability of repeated attacks.

PMID- 1015146
TI  - [Typology of defective states with a syndrome of monotonous activity in
      schizophrenic patients (problem of late remissions)].
AB  - The authors compared 2 types of defective states with a predominance of the
      syndrome of monotonous activity in the structure of a protracted remission in
      shift-like schizophrenia. Of the syndrome of monotonous activity of the 1st type
      the following conditions were most characteristic: autistic activity; a selective
      attraction to certain forms of work despite their relative high degree of
      organization and complexity; hyperactivity which was next to an overvalued
      approach to work. The 2nd type was characterized by a passive attitude to work, a
      significant restriction of forms of work and machine-like, similar to
      stereotypicity, character of activity.

PMID- 1015147
TI  - [Effectiveness of different methods of treating sleep disorders according to
      electropolygraphic findings].
AB  - The authors report of an electropolygraphical study of 111 patients with
      different forms of neurotical sleep disorders. For therapeutical purposes
      different pharmacological methods (Ca cyclobarbital, eunoctin, elenium,
      difenisid) and psychotherapeutical (hypnosuggestion, autogenic training)
      treatment was used. The achieved data permit to conclude that there is an
      increased activity of the awakening and activizing systems in patients with
      neurotic disorders of sleep. A decrease of the activating changes evoked under
      the influence of pharmacological and psychotherapeutical methods is accompanied
      by an improvement of the objective indices and as a rule correlates with a
      subjective personal feeling of sleep by the patient. The authors studied the
      optimal conditions for using different methods of treatment and based their
      principles for a differentiated therapy of different disorders of sleep in
      neuroses.

PMID- 1015148
TI  - [Effect of psycholeptics on several physiologic indices of stutterers].
AB  - The report is concerned with the action of single doses of aminazine, seduxen and
      benzctyzine on the EMG of the orbicular muscle of the mouth, pulse frequency, GSR
      and EEG during rest and in the process of speech in individuals with stuttering
      and neurotic disturbances (25 cases) and in early organic lesions (20 cases). The
      conclusion is made that there is a selective effect of these preparations on the
      different structures of the functional brain systems in stutterers.

PMID- 1015149
TI  - [Nurse-patient relations in a psychiatric department (experience with a social
      psychology study)].
AB  - The paper is related to some aspects of "nurse-patient" interrelations in
      conditions of rehabilitation of mental patients. The authors studied some factors
      influencing the evaluation (selection) of nurses by patients with the aid of
      special questionnaire techniques of nurses and patients in combination with the
      method of expert assessment. The study covered 141 mental patients and 14 nurses
      working in shifts. It was possible to distinguish some personality and
      occupational characteristics of the nurses who were most closely related to the
      estimation made by the patients. The authors established some relation between
      the assessment made by the patients with the degree of readiness for social
      contacts with mental patients by nurses.

PMID- 1015150
TI  - [Nature of hypnosis and its value in psychotherapy].

PMID- 1015151
TI  - Glycoprotein nature of tannase in Aspergillus niger.
AB  - 1. Tannase (tannin acyl-hydrolase, EC 3.1.1.20) was isolated from the culture
      medium of Aspergillus niger and purified about 200-fold. On polyacrylamide-gel
      electrophoresis it gave a single band. 2. The molecular weight of the enzyme was
      of the order of 55 000 as determined by gel filtration. The enzyme contains 21.5%
      of carbohydrates (mannose and glucose). 3. Treatment of tannase with alkaline
      borohydride decreased the content of threonine, serine and mannose, suggesting
      that the carbohydrate-peptide linkage is of the O-glycoside type, involving
      mannose linked to threonine and serine.

PMID- 1015152
TI  - Effect of some lipids on the activity of renin in vitro.
AB  - A partially purified bovine renin preparation and a homologous renin substrate
      were used to study the effect of some lipids on the amount of angiotensin formed.
      It was found that lecithin and the detergents used (deoxycholate and sodium
      dodecylate) inhibited the renin activity. Palmitic acid, oleic acid and
      cholesterol had no distinct effect. On the other hand, the reaction was enhanced
      by prostaglandins E2 and F2alpha.

PMID- 1015153
TI  - Uptake of folate and its analogue-amethopterin by mouse L-cells.
AB  - 1. The uptake of folate and amethopterin by the mouse transformed L-cells was
      found to depend on their extracellular concentration and time of incubation. The
      uptake conforms to Michaelis-Menten kinetics (Km values 10(-4) M and 10(-6) M for
      folate and amethopterin, respectively) and is temperature-dependent. 2. The
      observed differential effect of actinomycin D, cycloheximide and pCMB on the
      uptake of folate and amethopterin and lack of a pronounced transinhibition in the
      transport of these compounds indicate the existence in L-cells of two separate
      transport systems for folate and its analogue. 3. Methionine added to the culture
      medium enhances the uptake of folate, but not that of amethopterin. 4. Under
      conditions of methionine-dependent increase of folate uptake the activity of
      dihydrofolate reductase remains unaltered while that of methionine synthetase is
      markedly reduced. 5. The efficiency of folate uptake seems to be related rather
      to the modulations of methionine synthetase activity than to changes in the
      activity of dihydrofolate reductase.

PMID- 1015154
TI  - On sulfhydrylation of O-acetylserine and O-acetylhomoserine in homocysteine
      synthesis in yeast.
AB  - Considerable differences in the activities of cysteine and homocysteine synthase
      (EC 4.2.99.8), and in the ratio of these activities were observed in yeast
      strains representing different genera and species. This suggests that
      homocysteine synthesis directly from O-acetylhomoserine may predominate in some
      strains, whereas in the others homocysteine is formed from cysteine via
      cystathionine.

PMID- 1015155
TI  - Fluorescence of radiation-induced collagen aggregates.
AB  - Tropocollagen shows higher ultraviolet fluorescence (emission max, about 305 nm)
      and lower blue fluorescence (emission max. about 420 nm) than the dimers and
      tetramers isolated from irradiated collagen. This indicates dityrosine structures
      in the radiation-induced collagen aggregates.

PMID- 1015156
TI  - The presence of serine protease in pea embryo chromatin.
AB  - 1. It has been shown that chromatin from pea seedlings contains a proteolytic
      enzyme, similar to that of mammalian chromatin. 2. The protease was isolated from
      chromatin by acid extraction and partly characterized. It is a serine-type
      enzyme, sensitive to DFP, of low mol. wt. (about 18 000 - 20 000), with optimum
      pH at about 8 with [3H]N-acetylated histone as a substrate. 3. In chromatin
      complex, histones fl and f3 are preferentially degraded.

PMID- 1015157
TI  - Circular dichroism of partially purified cytochrome P-450 from rabbit liver
      microsomes.
AB  - The heme related circular dichroic bands of solubilized cytochrome P-450 from
      rabbit liver and some of its complexes with type I- and type II-substrayes and
      heme iron ligands were measured in the Soret region. All P-450 dersorption. The
      positions of the dichroic bands together with their ellipticities vary with
      ligand substitution and the oxidative state of the iron. The results are compared
      with CD-date of other hemoproteins and discussed with respect to stereochemical
      properties of the heme pocket.

PMID- 1015158
TI  - [Calcium-dependence of bradykinin-induced contraction in the isolated
      longitudinal muscle of the guinea pig ileum].
AB  - The calcium-dependence of the bradykinin-induced contraction was demonstrated on
      the isolated logitudinal smooth muscle of the guinea-pig ileum. Using the "La
      method" for measuring 45Ca entry into smooth muscle cells we were able to show,
      that bradykinin significantly increases the intracellular Ca-concentration. This
      effect of bradykinin was dose-dependent.

PMID- 1015159
TI  - Effect of chronic exposure to nitrogen dioxide on collagen fractions content in
      skin of guinea pigs.
AB  - Guinea pigs were exposed to nitrogen dioxide in concentration of 2 mg/m3 (8 hrs.
      daily, 180 days). Control group inspired fresh air. Collagen fractions were
      estimated in skin and assayed as hydroxyproline concentration. An increase of
      total collagen content, due to on increase of salt-soluble collagen fraction was
      found in the skin of the exposed animals, while a simultaneous decrease of
      insoluble collagen content was observed.

PMID- 1015160
TI  - Remarks on the investigation of sodium nucleinate by means of the limulus
      amebocyte lysate test.
AB  - Results of investigations of sodium nucleinate by means of the limulus amebocyte
      lysate (LAL) test are described. It was found that the sensitivity of this new
      pyrogen test to bacterial lipopolysaccharides is nearly the same as to sodium
      nucleinate, which is prescribed as pyrogen standard in the Pharmacopeia of the
      German Democratic Republic and recommended as such in the Compendium
      Medicamentorum.

PMID- 1015161
TI  - Stimulation of rat and cat heart adenylate cyclase by triiodothyronine in the
      presence of 5'-guanylylimidodiphosphate.
AB  - Adenylate cyclase activity in particulate preparations from the myocardium of
      rats and cats was unaffected by 3,3',5-triiodo-L-thyronine (L-T3) added in the
      absence of, or together with, 5-guanylylimidodiphosphate (Gpp(NH)p), a potent
      activator of the enzyme. Preincubation of the heart particles with Gpp(NH)p made
      the cyclase sensitive to L-T3 which then caused, in concentrations of 10(-8) M
      and higher, additional increases in enzyme activity up to about 50 per cent above
      the Gpp(NH)p-stimulated level. Similar effects after (GPP(NH)p treatment were
      produced by low concentrations of 3,3',5'-triiodo-L-thyronine (reverse T3) and
      3,3',5-triiodo-D-thyronine, whereas diiodo-tyrosine, 3,5-diiodo-L-thyronine, and
      3'-isopropyl-3,5-diiodo-L-thyronine were without significant effect. The
      stimulatory action of L-T3 on cardiac adenylate cyclase pretreated with Gpp(NH)p
      may help to explain some of the acute effects of thyroid hormones on the heart
      that have been reported in the literature.

PMID- 1015162
TI  - [Localization of adenylate cyclase in red and white skeletal muscle: a
      cytochemical study].
AB  - An attempt was made to demonstrate adenylate cyclase (ATP pyrophosphate-lyase
      (cyclizing) EC 4.6.1.1) activity in white and red skeletal muscle (M. psoas and
      M. soleus) of guinea pigs cytochemically by the lead precipitation technique. 5'
      Adenylylimidodiphosphate served as substrate. The free lead ion concentration in
      the incubation medium was kept below the value that is toxic to the enzyme. An
      electron dense reaction product, presumably lead imidodiphosphate, was deposited
      in the soleus muscle (red muscle fibers) at all parts of the plasma membrane and
      in the psoas muscle (white muscle fibers) chiefly at the membranes of the
      sarcoplasmic reticulum. The reaction at the latter site was enhanced by
      adrenaline; the enhancement was prevented by propranolol. These findings are in
      good agreement with results that have been obtained by other authors in
      experiments on subcellular fractions of the two types of muscle.

PMID- 1015163
TI  - [Glucose metabolism in different regions of the rat brain under hypokinetic
      stress influence].
AB  - In rats kept under long-time hypokinetic stress influence the glucose metabolism
      was studied in 7 brain regions. The regional levels of glucose, lactate,
      glutamate, glutamine, aspartate, gamma-aminobutyrate and the incorporation of 14C
      from plasma glucose into these metabolites, in glycogen and protein were
      determined. From the content and activity data the regional glucose flux was
      approximated guantitatively. Under normal conditions the activity gradient cortex
      and frontal pole greater than cerebellum greater than thalamus and mesencephalon
      greater than hypothalamus and pons and medulla is identical with that of the
      regional blood supply (measured with I131 serum albumin as the blood marker).
      Within the first days of immobilization a functional hypoxia occurred in all
      brain regions, and the utilization of cycle amino acids for protein synthesis was
      strongly diminished. After the first week of stress the capillary volumes of all
      regions increased, the aerobic glucose metabolism was enhanced (factors 1.3-
      2.0), and the incorporation of glucose-14C via cycle amino acids into protein was
      considerably potentiated. The metabolic parameters normalized between the 7th and
      14th week of stress. Blood supply and metabolic rate were most increased in the
      hypothalamus, reaching the value measured for the cerebral cortex in the initial
      state.

PMID- 1015164
TI  - [Asymmetric function of the pes hippocampi in experimental stress-induced
      arterial hypertension of albino rats].
AB  - Relations between a unilateral lesion of circumscribed structures of the Pes
      hippocampi on the one hand, and stress-induced blood-pressure and learning
      behaviour, on the other, were studied. An asymmetric functioning of the CNS was
      analyzed, in which unilateral exclusion of right-hand hippocampal structures
      stimulates processes of excitation, while lesion of left-hand structures causes
      prevalence of inhibitory processes. The resulting impairment of the emotional
      equilibrium potentiates the stress action's contribution to the development of
      arterial hypertension.

PMID- 1015165
TI  - Decreases of local brain temperature due to convection (local brain blood flow)
      and increases of local brain temperature due to activity.
AB  - The influence of local brain blood flow upon variations of local brain
      temperature in chronical experiments was investigated in cats. It was found that
      changes of local brain temperature in chronic experiments are esclusively due to
      changes of local metabolic heat production as long as the temperature of brain
      inflowing blood remains constant. Decreases of temperature due to convection
      (increase of local blood flow) are smaller than increases of temperature due to
      activity.

PMID- 1015166
TI  - [Experimentally produced neurogenic-interoreceptive hypertension in the rat].
AB  - A hypertension characterized by systolic and diastolic blood pressure rises and
      increase in heart rate was produced in albino rats by excluding sino-aortal
      baroreceptors. Cardiac output and peripheral resistance, measured unter barbital
      narcosis, exhibited no significant changes in the development of hypertension.
      With the only exclusion of aortal baroreceptors there occurred almost the same
      blood pressure rises as with sino-aortal deafferentiation. It is concluded
      therefore that this kind of partial elimination of baroreceptors involving a
      simplified operational technique and lower risk will suffice for many problems
      being studied in hypertension research.

PMID- 1015167
TI  - [Dynamics of adaptation and maladaptation phenomena in rats exposed to weak
      chronic stimulation].
AB  - Experiments were carried out with rats to study the influence of disturbing
      artifical light-dark regimens. The findings are consistent with the definition of
      "relatively weak stress-stimuli" which, according to R. BAUMANN, can be essential
      in causing regulation diseases. Disturbances in the circadian patterns of
      spontaneous motor activity are described as an inversion of normal activity
      maxima and minima, as periodicity step-down and as a dissolution of the day
      periodical order. Their occurrence is proportional to the magnitude of the
      disturbing effect. As vegetative disturbing effects there occurred transient
      hypertensive derangements, the extent of which is inversely proportional to the
      magnitude of the stressing stimulus. These differences are discussed basing on a
      hypothesis of differently synthetized cerebro-visceral regulation mechanisms.

PMID- 1015168
TI  - [Use of various statistical procedures for the analysis of biorhythms
      (periodicities of conditional-reflex processes in the minute range) under
      emotional stress and physical exercise].
AB  - Periodicities of conditional-reflectory processes in the minute range were
      measured in albino rats kept under various conditions (emotional stress,
      exercise, normal stall maintenance) and analyzed by different statistical
      procedures. It was possible in this way to judge by selected parameters of
      periodical processes the intensity of loads and effects of exercise. The
      additional use of cluster analysis for scaling the biological effectiveness of
      different communicative relations of the organisms proved useful.

PMID- 1015169
TI  - [Diurnal dynamics of periodicities in conditional-reflex processes in the minute
      range].
AB  - Male adult albino rats living from the 6th week of their lives under conditions
      of artificial light-dark cycle (16 hrs light, 8 hrs dark) were used to study
      possible relationships between circadian sensitivity cycles and synchronization
      of dynamics and the frequency variability of periodicities of reaction times of
      conditional-reflectory processes with wavelengths in the minute range. The
      experiments have revealed differences at the time of the activity maximum and
      minimum of a circadian cycle in the studied parameters of the minute rhythm (mean
      level of oscillation, mean amplitude, length of period and coupling). In the dark
      phase (activity maximum) there prevailed an increased level of central-nervous
      excitation and a tendency towards a higher frequency and diminished coupling of
      minute periods. In the light phase (activity minumum) the animals showed a
      balanced level of excitation, reduced frequency and a rigid coupling of
      periodicities of conditional-reflectory events involved in the process. Relations
      are shown to exist between central-nervous processes and circadian sensitivity
      cycles. For the experimental practice it is concluded that the different times of
      the day should be accounted for in assessing the criteria of minute rhythm and in
      conditional-reflectory studies in pharmacology and toxicology.

PMID- 1015170
TI  - [Studies on the blood pressure effects of various high doses of angiotensin II in
      depot form in rats under defined conditions].
AB  - Daily s.c. injections of 0.02--10.0 mg angiotensin in depot form for 14 days
      caused in rats, under defined conditions, pronounced dose-dependent effects, with
      an unusual tolerance to the drug being observed. The behaviour of the systolic
      and diastolic blood pressure and heart rate allowed to define 4 dose ranges. In
      the lowest dose range of 0.02 mg angiotensin-II a lasting borderline hypertension
      with only straight-line changes of diastolic blood pressure and bradycardia were
      observed. The doses of 0.15--1.25 mg angiotensin-II caused a continual blood
      pressure rise and led, between day 4 and 6 of the experiment, to a pronounced
      lasting resistance high-pressure without appreciable changes in heart rate. The
      strongest resistance high-pressure, which occurred as early as on day 3, with
      pronounced tachycardia was achieved with a dose of 2.5 mg angiotensin-II. Higher
      doses produced pronounced tachycardia but no significant effects on blood
      pressure. The varying dose-dependent effects of depot angiotensin are discussed,
      and the possibility is pointed out to study by the angiotensin-II hypertension
      model various mechanisms of a long-time hypertensive dysregulation.

PMID- 1015171
TI  - [Effect of angiotensin II depot administration on bioelectric functional
      processes of the central nervous system].
AB  - Using the average evoked potential technique, angiotensin-II depot effects (1 mg
      implantate = 3--4 mg/kg body weight angiotensin-II) were studied
      neuroelectrophysiologically in reticular, hippocampal and neocrotical structures
      of albino rats. A multivariate variance and discriminance analysis program
      revealed differentiated changes of the bioelectrical processing data of the CNS.
      Evidence was obtained for a varying structural sensitivity of central-nervous
      substructures under depot administration of angiotensin-II. In later phases of
      angiotensin-II action, the hippocampus was characterized by an electrographic
      synchronization phenomenon with high-amplitude average evoked potentials. The
      reticular formation, and to a lesser extent the visual cortex, showed an
      angiotensin-induced diminution of bioelectrical excitation. However, the
      intensity of the change in functional CNS patterns did not always correlate with
      maximal blood pressure rises. The described changes of afference processing to
      standardized sensory stimuli, especially in hippocampal and reticular structures
      of the CNS foll owing angiotensin depot action, point to a central-nervous action
      mechanism of angiotensin-II.

PMID- 1015172
TI  - N-terminal amino acid sequences of pepsinogens from dogfish and seal and of
      bovine pepsinogen B.
AB  - The N-terminal amino acid sequences of dogfish pepsinogen (8 residues), seal
      pepsinogen (26 residues) and bovine pepsinogen B (25 residues) have been
      determined. The primary structures of all three pepsinogens show considerable
      homology with those of zymogens of gastric proteases sequenced previously.

PMID- 1015173
TI  - Review of 1,375 cases of vascular reconstruction for ischemic disorder of the
      lower limbs Statistical analysis of late postoperative thromboses with evaluation
      of the effect of an anti-platelet agent[tauthor's transl)].
AB  - The authors are presenting 1.375 cases of arterial reconstruciton of the lower
      limbs, those patients having undergone 1.562 operatons between 1963 and 1974.
      Although mention is made of long-term postoperative morbidity (false femoral
      aneurysm, infection, amputation), the study is mainly centered on the problem of
      late thromboses, calculated in percentages per year and classified according to
      the time lapse since the initail operation. Comparison is made between the
      percentages before and after 1972. Since 1972, Dipyridamol, an anti-platelet
      agent, has been administered systematically to all vascular reconstructions of
      the lower limbs. The action of this type of drug on the platelet adhesivenss is
      briefly treated. In this respect the numbers calculated suggests a decrease of
      about 25 % in the numbers of late thrombosis, all other treatment remaining
      unchanged for the past 11 years. In conclusion, operative indication and surgical
      skill remain primordial in this type of surgery. However, the anti-platelet
      treatment, associated with fat-free diet, no tobacco, vasodilators or
      anticoagulants, seems to bring a further guarantee to permeability of arterial
      reconstructions.

PMID- 1015174
TI  - [Treatment of spontaneous pneumothorax and prophylaxis of relapses (author's
      transl)].
AB  - This study reports the treatment of 192 consecutive cases of spontaneous
      pneumothorax observed in 99 patients. Relapses are frequent, but it could be
      shown that their number can be reduced by more aggressive therapy. Conservative
      treatment led to 99 % of relapses, whereas they were reduced to 32 % by
      continuous pleural suction, as shown in 76 cases. Pleurodesis with glucose 40 %
      or 50 % solution followed by continuous suction for 7 days, is advertised by the
      authors for every first episode of spontaneous pneumothorax. Under this treatment
      relapses were observed in only 19 % of the cases. If however after this treatment
      a recurrent pneumothorax occurs, thoracotomy has to be considered for parietal
      pleurectomy and occasional resection of emphysematous bullae. This procedure was
      successfull in all 13 cases where it had been applied.

PMID- 1015175
TI  - [Diaphysal pseudarthrosis of the tibia (author's transl)].
AB  - The authors analyse the etiology and treatment of 18 pseudarthroses of the tibial
      diaphysis occurring in a series of 320 fractures of this bone. This complication
      seldom appears in simple fractures treated by a plaster cast (two cases out of
      144). In addition to classical and well known factors, it appears that
      pseudarthrosis occurs more frequently after traction-immobilization (10 cases out
      of 73), when the fragments had to be repositioned on many occasions under plaster
      cast, or in cases of open fractures. The treatment by bone grafting, principally
      in-lays, with or without plates and visses, yield satisfactory results.

PMID- 1015176
TI  - [Surgery for chronic non neoplastic diseases of the pancreas (author's transl)].
AB  - The authors analyze the surgical indications and procedures for cases of chronic
      pancreatites. There were but few cases and the procedures were chosen for minimal
      harm ; there were : 4 external marsupialisations, 1 resection of a true cyst, 5
      cystoanastomoses, 2 biliary bypasses, 4 left pancreatectomies. Postoperative
      courses were normal in 12 patients; 2 had recurrent pancreatitis because of
      alcoholism. Our attitude towards chronic pancreatic lesions is thus as follows:
      1. Cautions and reserved indications. 2. Ad minima procedures.

PMID- 1015177
TI  - [Idiopathic infarct of the omentum (author's transl)].

PMID- 1015178
TI  - [Ulcer of the colon and Mallory-Weiss syndrome (author's transl)].
AB  - A 71 year old man presents with a high and low hemorrhage with no signs of
      associated shock. Endoscopy shows a laceration of the cardia (Mallory-Weiss
      syndrome). The low hemorrhage is attributed to a left colic lesion that appears
      to be an ischemic colitis. Colonoscopy in addition to baryum enema is useful in
      the differential diagnosis of colon lesions.

PMID- 1015179
TI  - [Classification and operative tactic in the treatment of the small ptotic breast
      (author's transl)].
AB  - The deceiving results obtained by the single implantation of mammary prostheses
      in the treatment of the small ptotic breasts are the consequence of faulty
      judgment and lack of recognition of the various anatomical elements involved in
      the deformity and which bear an incidence on the operative technique and the
      final esthetic result. By studying the three inseparable elements -ptosis, skin
      and hypoplasia -a classification into three types of small ptotic breasts is
      proposed, based mainly on the origin of the ptosis and the hypoplasia and on the
      static qualities of suspension and coverage of the skin : Type I : primary small
      ptotic breast. Type II : secondary small ptotic breast with normal skin. Type III
      : secondary small ptotic breast with skin of bad quality. The respective
      indications and prognosis of the classical methods of treatment are reviewed
      according to this classification. The single implantation of mammary prostheses
      has only restricted indications : when the ptosis of the nipple and/or the lower
      pole of the breast does not exceed 1 tot 1,5 cm. In all the cases where the
      ptosis is more pronounced, the single implantation is contraindicated and a
      reshaping operation will be performed. In cases where the reshaping operation
      does not give enough volume to the breast, a two-stage procedure is strongly
      recommended by the author : a reshaping operation, followed in a second stage by
      the implantation of the adequate prosthesis as soon as the local conditions are
      favorable.

PMID- 1015180
TI  - [Reimplantation of severed fingers (author's transl)].
AB  - Finger reimplantation is actually feasible. Two cases of complete amputation and
      three of partial amputation are presented. There were four successes out of five.
      A partial reimplantation failed on the 12th postoperative day. The technique and
      the postoperative care are presented. Success does not depend solely on
      technique. Physiopathology of the microcirculation at the level of the
      anastomoses, not well known at present, conditions vascular patency and survival
      of the reimplanted finger.

PMID- 1015181
TI  - [Prophylaxis of postoperative deep vein thromboses by means of weak doses of
      subcutaneous heparin (author's transl)].
AB  - The authors intend to control with the marked fibrinogen test, the real frequency
      of postoperative deep vein thromboses (DVT) and the eventual prophylactic effect
      of subcutaneous heparin in weak doses. Heparin was administered 2 hours before
      the operation and every 8 hours during 6 days thereafter, each time at the dose
      of 5,000 U subcutaneously. Ninety-nine patients undergoing major surgery were
      randomized into two groups of 55 control operated patients and 44 operated
      patients treated with heparin. The radioactive fibrinogen test was used in 27
      patients of the control group and in 23 of the treated group. In the control
      group of 55, 7 DVT were clinically recognized : the isotopic test was positive in
      17 patients. In the treated group of 44 no DVT was clinically diagnosed : 6 DVT
      were recognized by the marked fibrinogen test. There were no noticeable
      hemorrhagic complications in the treated group. Low dose of subcutaneous heparin
      is an efficient and safe prophylactic method in postoperative thromboembolic
      accidents.

PMID- 1015182
TI  - Renal artery stenosis and occlusion.
AB  - Renovascular hypertension caused by renal artery stenosis was a coincidental
      discovery in 5 of the 6 patients presented. They did not have any comlaint and it
      was by routine bloodpressure measurement that hypertension was diagnosed. In one
      patient without hypertension stenosis of both renal arteries was seen on the
      aortography for an infrarenal aortic occlusion. Depending on the extent and
      localisation of the stenosis unilateral renal artery stenosis was treated by a
      saphenous vein graft interposition, or by an aortorenal vein patch. In a man with
      bilateral renal artery stenosis a venous bridge was constructed. Once an
      unilateral nephrectomy was necessary, the kidney being atrophic and a vascular
      correction impossible.

PMID- 1015183
TI  - [New views on the pathogenesis of arthrosis].

PMID- 1015184
TI  - [Pelvic osteotomy using the Chiari technic].

PMID- 1015185
TI  - [Surgical treatment of the iliotibial-tract-shortening syndrome resulting from
      infantile paralysis].

PMID- 1015186
TI  - [Chondromalacia of the patella, a common cause of diagnostic errors in knee-joint
      disorders].

PMID- 1015187
TI  - [An unusual case of Brucella osteomyelitis].

PMID- 1015188
TI  - [Substitution of ligaments using bands of plastic material. (Experimental
      study)].

PMID- 1015189
TI  - [Fractures of the arch of the second cervical vertebra].

PMID- 1015190
TI  - [Anatomical and functional results of conservative therapy of diaphyseal forearm
      fractures in children].

PMID- 1015191
TI  - [Bone remodeling of displaced diaphyseal femoral fractures in children].

PMID- 1015192
TI  - [The radiological and endoscopical apsects of benign and malignant ulcerations of
      the stomach (author's transl)].

PMID- 1015193
TI  - [Study of an epidemic of HBsAg, subtype (ay), hepatitis (author's transl)].

PMID- 1015194
TI  - [Report on a case of leiomyoblastoma of the stomach (author's transl)].

PMID- 1015195
TI  - [Basal and postprandial gastrinemia determinations: their value in the study of
      gastric diseases other than the Zollinger-Ellison syndrome (author's transl)].

PMID- 1015196
TI  - Metastatic cancer of the liver. Retrospective analysis of the clinical features
      in 166 patients with discussion on the possibility of early diagnosis.

PMID- 1015197
TI  - [Gastric localisation of malignant lymphogranulomatosis. Case report (author's
      transl)].

PMID- 1015198
TI  - [Digestive lesions induced by kalium chloride. Report on 16 cases among which one
      oesophageal and six gastric localisations (author's transl)].

PMID- 1015199
TI  - [Report on a case of iatrogenic diaphragmatic hernia (author's transl)].

PMID- 1015200
TI  - [Familial polyposis of the colon, associated with extracolic lesions and with a
      degenerated polyposis of the stomach (author's transl)].

PMID- 1015202
TI  - Psychological and psychophysiological aspects of work and fatigue. (A review of
      papers presented at PC-IAOH Sub-Committee meeting on Higher Nervous Functions,
      Prague, july, 1975).

PMID- 1015201
TI  - Cefazolin in the treatment of biliary tract infections.

PMID- 1015203
TI  - Neuro- and psychotropic effects of industrial chemicals and performance-affecting
      drugs (human studies). A review of papers presented at the Workshop of PC-IAOH
      Sub-Committee on Higher Nervous Functions, Prague, July 1975.

PMID- 1015204
TI  - Neurobiological and behavioural toxicity in animals. a review of papers presented
      at the workshop of PC-IAOH sub-committee on Higher Nervous Functions, Prague,
      July 1975.

PMID- 1015205
TI  - Central processing and the role of inhibition in the development of healthy
      learning.

PMID- 1015206
TI  - Development of instrumental learning and memory processes in mice.

PMID- 1015207
TI  - Ontogeny of active avoidance learning and memory.

PMID- 1015208
TI  - Ontogenetic factors in the retrieval of memories.
AB  - Although rats may show extensive forgetting if a long interval is interpolated
      between an aversive-conditioning episode and a retention test, this forgetting
      can be alleviated by a variety of reactivation treatment. This paper reports
      several experiments analyzing the consequences of one reactivation treatment -
      noncontingent presentation, between conditioning and testing, of the
      unconditioned stimulus - when applied to rats which differ in the age at which
      they are given their conditioning episode. After a long retention interval, both
      paradigms tested using this reactivation treatment are relatively ineffective for
      animals conditioned when 16--17 days of age, although both paradigms markedly
      alleviate forgetting when such immature animals are tested after relatively short
      retention intervals (a similar effect seems to occur with very old rats).
      Implications of this finding are tested and discussed.

PMID- 1015209
TI  - Triggering effect of the perinatal crisis on the conditioned reaction in newborn
      guinea-pig.

PMID- 1015210
TI  - Usefulness of piracetam in intensive care.

PMID- 1015211
TI  - Meptazinol: I.M. use in postoperative pain.
AB  - In a population of 39 patients, the new analgesic drug Meptazinol was tested in
      postoperative period at a dose of 100 mg I.M., administered only on request of
      the patient. Cardiovascular and respiratory parameters were not altered
      significantly. The onset of analgesia was rapid (+/- fifteen minutes) with a
      maximum reached after thirty minutes; the provided analgesia was good for about
      two hours as evaluated by the anesthetist and the nurse. The patient asked for a
      new dose only after about five hours.

PMID- 1015212
TI  - First experience with a new analgesic drug: buprenorphine.
AB  - Buprenorphine, a new analgesic drug, was used for treatment of immediate
      postoperative pain in a group of 30 patients. A standard dose of 4 mug/kg was
      given IM. Onset of action occurred 10 to 20 min. later; pain relief was very good
      to good in 73%, fairly good in 23% and insufficient in 3%. Duration of action was
      very long (Mean + SEM: 360 +/- 32 min.) Side effects were few.

PMID- 1015213
TI  - Clinical study on etomidate.

PMID- 1015214
TI  - Etomidate, a new short acting, intravenous hypnotic.
AB  - Etomidate can be recommended for short procedures combined with fentanyl and for
      the induction of neuroleptanesthesia. It has advantages in poor risk patients
      because it has only negligible effects on the heart and the peripheral
      circulation. It has to taken in consideration though, that etomidate has only
      hypnotic and no analgesic action.

PMID- 1015215
TI  - Clinical use of etomidate, influence on blood pressure and heart rate. Comparison
      with thiopentone and methohexital.
AB  - This study deals with blood pressure and heart rate measurements during the use
      of etomidate after premedication; the injection of etomidate is always preceded
      by 0.10 mg of fentanyl. Etomidate is compared with thiopentone and methohexitone.
      There appears to be no gross difference between the drugs as far as the blood
      pressure is concerned: it is decreased by 15-20%. The influence on the heart rate
      is typical for each drug: whereas thiopentone causes a rise of 23%, and
      methohexitone of nearly 40%, the rate remains constant in the etomidate series.

PMID- 1015216
TI  - Clinical use of etomidate.
AB  - Etomidate and methohexital were administered for induction of anesthesia in 45
      patients who had to undergo open heart surgery. The anesthesia technique was
      otherwise standardised. Measurements of blood pressure and heart rate were
      obtained during a period of ten minutes after injection of the induction agent,
      and in a selected group of 16 patients cardiac index and stroke volume index were
      obtained by impedance cardiography. In the group of 45 patients, blood pressure
      one minute after induction was unchanged with Etomidate, but decreased (-6%) with
      methohexital. During intubation, important variations of systolic blood pressure
      occurred, specially with Etomidate (+ 36%) and less with methohexital (+ 21%).
      Heart rate increased in both groups during intubation (+ 41%) and returned
      towards starting value after ten minutes. In the group of 16 patients, cardiac
      index varied with Etomidate, decreasing during intubation (- 21%), increasing to
      + 32% and then returning to starting value afterwards. Heart rate increased with
      intubation (+ 39%) and was still somewhat elevated at ten minutes. Stroke volume
      index decreased with intubation (- 36%) and was still lower than the initial
      value at ten minutes (- 14%). With methohexital, cardiac index variations were
      less pronounced (+ 11%). Cardiac index was lower than the initial value at ten
      minutes (- 14%). Stroke volume index decreased with intubation (- 36%) and was
      still lower than the initial value at ten minutes (- 14%). This was compensated
      by an increase in heart rate. These measurements made during induction reflect
      the complex interaction of drug administration and technical manipulations. Blood
      pressure lowering one minute after the injection of methohexital can be ascribed
      to vasodilatation and myocardial depression. The important blood pressure and
      cardiac index variations observed with Etomidate are probably due to the short
      action and the lack of analgesic properties of this agent.

PMID- 1015217
TI  - Influence of etomidate, a new short acting anesthetic agent, on cerebral blood
      flow in man.
AB  - Cerebral blood flow was measured by means of a ten channel cerebrograph. This
      investigation was done after a corotid angiography; 2 to 3 miCi of Xenon133 was
      injected in the internal carotid artery. Beside CBF we measured arterial
      bloodpressures, heart rate, stroke volume, cardiac output, central venous
      pressures, blood gases and glucose in arterial blood, blood gases and glucose in
      the bulbus of the internal jugular vein and blood gases in mixed venous blood. In
      most regions CBF decreased significantly after Etomidate. The other parameters
      did not change. Only the heartrate slowed significantly.

PMID- 1015218
TI  - Etomidate and tonsillectomy.
AB  - Tonsillectomy under general anesthesia, one of the most commonplace operations
      there are, is more of a problem for the anesthetist than for the surgeon. Once
      intubated, the child or adult will be protected from any operative risks by
      correct ventilation and the protection of his upper airways. The only problem is
      that arising from the anesthesia required to carry out this intubation and from
      the consequences of this anesthesia on the waking period, which should be brief
      in order to avoid, after detubation, any reactions which might induce excessively
      deep sleep at that moment. In this respect we found etomidate, with its short
      duration of action, even after reinjection, just as interesting as methohexital.
      We should mention, however, that his product presents certain disadvantages the
      most troublesome of which seemed to be the pain provoked when this substance is
      injected. A new solution (of basic etomidate) still hardly presented this
      disadvantage.

PMID- 1015219
TI  - A comparative study of etomidate and methohexital as induction agents for
      analgesic anesthesia.
AB  - Two hundred current surgical procedures were done in adult patients using
      neuroleptanalgesia with either methohexital (1 mg/kg) or etomidate induction (0.3
      mg/kg) in half of the cases. The cardiovascular function was less altered with
      etomidate (less occurrence of tachycardia, blood pressure drops or systolo
      diastolic pinching). The etomidate dosage chosen more often gave an immediate
      satisfactory sleep. However, with methohexital induction, less signs of awakening
      were observed during the surgical procedure. The frequent postoperative
      somnolence also points, although indirectly, to a longer residual effect of the
      barbiturate. Both drugs sometimes gave erythema. The injection of etomidate was
      more frequently painful in the arm. On the other hand, hiccups occurred with
      methohexital induction only. Etomidate induced myoclonia in one-third of the
      cases premedicated with diazepam and after preliminary injection of a minimal
      amount of fentanyl. Without these precautions, myoclonia can occur in two-thirds
      of the patients. However, these myoclonia are bothersome and of prolonged
      duration in rare instances and would be of real annoyance only when this drug
      would be used alone for surgical procedures of short duration where perfect
      patient immobility is required. We therefore conclude and confirm that etomidate
      is a good induction agent for neuroleptanalgesia anesthesia procedures.

PMID- 1015220
TI  - Clinical study of althesin and hypnomidate.
AB  - A simple clinical and a more elaborate instrumental study are presented on the
      cardio-circulatory action of Althesine and Etomidate (Hypnomidate) compared to
      thiopental (Pentothal). Statistically is Althesin not significantly worse than
      thiopental but significantly worse than Hypnomidate. Hypnomidate is less
      aggressive than thiopental although non significantly. Succinylcholine (1 mg/kg)
      aggravates the heart depressant actions of the tested drugs, while the intubation
      of the trachea produces sometimes a serious pressor response which can not be
      always blocked by prior administration of a low dose (0.1 mg i.v.) Fentanyl.

PMID- 1015221
TI  - Cardiovascular effects of various anesthetics in man. Four short-acting
      intravenous anesthetics: althesin, etomidate, methohexital and propanidid.
AB  - Four groups of 15 patients without any cardiovascular or pulmonary pathology
      received an intravenous injection of one of the 4 studied anesthetics, Althesin
      (0.07 ml/kg), Methohexital (1.6 mg/kg), Etomidate 0.15 mg/kg) or Propanidid (6
      mg/kg). Arterial pressure, heart rate, stroke volume and cardiac output were
      measured every thirty or sixty seconds. Stroke volume decreased and heart rate
      increased with all of them, but most of all with Propanidid. The only
      statistically significant reduction of cardiac output was observed with Althesin.
      Arterial pressures did not vary. Under the conditions of the present study and at
      the dose levels mentioned, Etomidate produced the least changes in cardiac
      parameters.

PMID- 1015222
TI  - Study of the cerebral blood flow in patients with brain lesions under anesthesia.
AB  - The influence of thiopental (Pentothal) on cerebral blood flow was studied by
      means of ten scintillationcounters in man on occasion of a carotid angiography.
      The patients received a basic anesthesia with 30% oxygen, 70% nitrous oxide and
      pancuronium bromide. When the anesthesia was stabilised, thiopental was given (4
      mg/kg). The influence of barbiturates on autoregulation is discussed.

PMID- 1015223
TI  - Cardiovascular effects of different anesthetics in man. Study of two volatile
      anesthetics: enflurane (ethrane), halothane (fluothane).
AB  - In the first part of this paper we report the effects of 4 short acting
      intravenous anesthetics (althesin, etomidate, epontol, brietal) on the
      cardiovascular effects due to ethrane. In the second part we learn with the same
      induction anesthetic (etomidate) the cardiovascular effects of ethrane and
      fluothane. We have proved that: 1 degree althesin least potentiates the
      variations in the cardiovascular parameters under the action of ethrane, 2
      degrees halothane 2% decreases more the blood pressure than ethrane 1%.

PMID- 1015224
TI  - The effects of Ethrane on the hemodynamics of pulmonary circulation.

PMID- 1015225
TI  - Cerebral blood flow under enflurane anesthesia.
AB  - Cerebral blood flow was measured, under controlled conditions of stable
      ventilation and PaCO2, in 11 patients suffering from cerebro-vascular lesions.
      Comparing the results under N2O-enflurane 1% anesthesia with those under N2O
      fentanyl anesthesia shows an average 8.4% decrease of blood flow. In 5 cases, a
      third measurement was performed under N2O-enflurane 2% anesthesia. This caused an
      average 8.5% complementary decrease. Whereas most inhalational anesthetic agents
      produce an increase of cerebral blood flow, this is not observed with enflurane,
      the tendency rather being towards a decrease.

PMID- 1015226
TI  - Influence of enflurane on blood loss from the pregnant uterus.
AB  - Uterine blood loss was measured in women undergoing therapeutic abortion during
      the first trimester of pregnancy. A first group, operated under paracervical
      block anesthesia, had a mean blood loss of 17 ml. The second group, anesthetized
      with pentothal, nitrous oxide and enflurane 1%, had a mean loss of 41 ml. The
      difference is statistically highly significant, but absolute blood losses
      remained small in both groups.

PMID- 1015227
TI  - The effect of enflurane and halothane on normal values of pulmonary function.

PMID- 1015228
TI  - Impaired early insulin response to glycemic stimulus during enflurane anesthesia
      in dogs.
AB  - We assayed glucose tolerance and insulin secretion in unanesthetised dogs and
      during enflurane anesthesia. When compared to the awake control animals,
      enflurane administration induced glucose intolerance with mild hyperglycemia
      resulting from decreased basal insulin secretion. Moreover, insulin secretion in
      response to a glycemic stimulus (intravenous glucose tolerance test) was
      impaired. Comparison between the net incremental insulin responses and the
      cumulative insulinogenic indexes suggests impaired insulin secretion is mainly
      related to a deficit in secretion from the acutely releasable insulin storage
      pool.

PMID- 1015229
TI  - Study of the renal function during anesthesia with halothane and enflurane.
AB  - In this work, the renal function of ten patients has been studied during an
      anesthesia with halothane (5 patients) or enflurane (5 patients), a new volatile
      anesthetic agent. Before and during the anesthesia, the patients were perfused
      with Lactate Ringer solution. Blood and urine samples were regularly collected to
      allow the measures of the various parameters of the renal function. Halothane
      decreases the glomerular filtration rate, the renal plasmatic flow; the filtrated
      fraction remains stable. Enflurane decreases the glomerular filtration rate but
      increases the renal plasmatic flow; besides the filtrated fraction decreases. As
      far as water and electrolytes are concerned, halothane mainly decreases the urine
      output, the osmolar clearance and the fractional excretion of sodium. This
      suggests that it chiefly acts on the proximal tube of the nephron. Enflurane
      mainly decreases the urine output and the free water clearance. This suggests an
      effect on the distal tube of the nephron.

PMID- 1015230
TI  - New anesthetic agents.

PMID- 1015231
TI  - Ocular tonometry in the child under general anesthesia with IM ketamine.
AB  - In the young child, the ocular tension cannot be taken without general
      anesthesia. Most of the anesthetic drugs lower the ocular tension which may give
      false low results in glaucoma. Ketamine is the only practical drug elevating the
      ocular tension. To determine the amount of the change in ocular tension under
      ketamine, the ocular tension was measured under I.M. ketamine 5 to 10 mg/kg in 30
      children without ocular disease. The ocular tension before the anesthesia has not
      been measured. As soon as the child fell asleep, the ocular tension was recorded
      between 15 to 20 minutes. We  noticed that the ocular tension remains stable in
      the beginning, but that it tends to rise after eight minutes of narcosis. So the
      ocular tension must be measured as soon as possible after induction, as soon as
      the child does not react to stimuli. Abnormal ocular tensions under ketamine are
      discussed. The ocular tensions under two different types of anesthesia (ketamine
      and methohexital + Thalamonal) are compared. Some examples of ocular tensions in
      glaucoma under ketamine are presented.

PMID- 1015232
TI  - Post-traumatic and postoperative treatment of severe brain injuries with
      controlled hyperventilation.
AB  - Controlled hyperventilation has shown to be an effective method of treatment in
      patients with pronounced brain edema and high ICP caused by accidental or
      surgical damage. This treatment has to be started as early as possible after the
      injury to avoid secondary changes and spreading cerebral edema leading to the
      impact of the brain-stem and thus irreversible brain damage. If conducted
      consequently, controlled hyperventilation will diminish mortality rate and
      increase the rate of valuable recoveries in all sorts of brain injuries.

PMID- 1015233
TI  - The prevention of irreversible lung changes following reversible phrenic nerve
      paralysis.
AB  - Phrenic nerve paralysis frequently follows operations on the neck such as
      resection of a cervical or first rib. It all too often passes unrecognised or is
      incorrectly treated, leading to permanent lung damage which may be severe enough
      as to result in a functional pneumonectomy. This is particularly unfortunate
      since the phrenic nerve paralysis is usually temporary. Three case histories are
      described of reversible paralysis of the phrenic nerve in which, due to prompt
      diagnosis, the ensuing lung changes were either prevented or immediatley treated.
      Intermittent assisted respiration with a Monaghan respirator was used to provide
      nebulised inhalations of Mesna several times a day. The method is applicable via
      a tracheostomy, an endotracheal tube or a simple mouthpiece. The latter is
      illustrated. The therapy is not hindered by immobilisation of the head and neck
      and the level of consciousness of the patients is of no importance. Many chest X
      rays demonstrate the rapid clearing of the lungs achieved. All three patients
      were discharged with perfectly normal lungs.

PMID- 1015234
TI  - Management of potentially fatal alcohol intoxication.
AB  - Severely alcohol intoxicated patients pass through all stages of anesthesia
      according to the Guedel classification. Additional illnesses or injuries might be
      present, however. These require careful investigation. Blood alcohol levels are
      no criterion for the degree of intoxication. The treatment varies and is based on
      clinical symptoms. In our series of more than 100 alcohol intoxicated patients
      the treatment generally consisted o Apomorphine, unless unconsciousness was
      present, and peripheral vasopressors, if necessary. Occasionally endotracheal
      intubation was required. On gastric aspiration via nasogastric tube only minimal
      amounts of alcohol could be recovered. With correct diagnosis and effective
      treatment the cure rate of acute alcohol intoxication should be as high as that
      of other intoxications.

PMID- 1015235
TI  - A computer module for the continuous monitoring of cardiac output in the
      operating theatre and the ICU.
AB  - A new pulse contour method to determine stroke volume and cardiac output
      continuously in patients on a beat-to-beat basis from the aortic pressure wave
      has been implemented in the form of a simple, inexpensive, fully automatic
      computing module for a commercially available patients monitoring system (Philips
      Medical Systems). Its reliability has been tested and shown in a computer analog,
      in experimental studies in 10 dogs (not reported here), in 22 hemodynamic studies
      on 20 young healthy volunteers and during 41 days in 20 postsurgical patients in
      the ICU, the most important result being that erros figures (15 and 19%
      respectively in the two human studies) are of the same order as when two standard
      methods, Fick and dye dilution are compared. The clinical studies have further
      indicated the easy applicability of the module 1 degree in the monitoring of
      critically ill patients in ICU's, 2 degrees as a monitor of the systemic
      circulation during anesthesia, and 3 degrees as a tool for studying the
      hemodynamic effects of pharmacological agents. The instrument consitutes no
      burden to the patients and has, several times during the course of the
      evaluation, provided an early warning of a deteriorating hemodynamic status of
      the patient to the physician.

PMID- 1015236
TI  - Study on peroperative bleeding in ear, nose and throat surgery.
AB  - Some interventions in ENT surgery are very difficult or are even impossible if
      the slightest bleeding occurs. Microsurgery of the ear is the best example. For
      this reason we choose this particular intervention to test different anesthesia
      techniques. Bleeding in the surgical field is followed, while simultaneously
      respiratory, venous and arterial pressure tracings are recorded. These parameters
      are followed and changes can be attributed directly to observations by microscope
      of the surgical field. Successively neuroleptanalgesia in its pure form or with
      help of several drugs (trimetaphan, furosemide, enflurane) is studied. One
      conclusion can probably be made of the analysis of our series: an anesthesia with
      "light" analgesia gives better results than an anesthesia protecting completely
      the patient.

PMID- 1015237
TI  - Controlled hypotension induced by sodium nitroprusside. A practical approach.
AB  - Although known since 1849 and introduced in medical practice 1955, sodium
      nitroprusside is used mostly in large medical centres fully equipped with
      monitoring equipment. This attitude has contributed that sodium nitroprusside is
      not as popular as it should be. An attempt is made to show that single banded
      practising anesthesist may and should use sodium nitroprusside to produce
      controlled hypotension, provided certain "safeguards" are followed. These
      safeguards are based on information got from the literature and own experience
      with sodium nitroprusside in obtaining controlled hypotension during anesthesia
      using sophisticated equipment as well as simplified monitoring, which is fully
      explained in the article.

PMID- 1015238
TI  - Cardiovascular effects of metacrylate methyl monomer intravenous injections in
      dogs.

PMID- 1015239
TI  - Some experience of the use of etomidate in children.
AB  - Etomidate 0.2 mg/kg was used as an intravenous hypnotic to induce anesthesia in
      198 children. If proved to be a safe and effective agent, with no appreciable
      side-effects on the cardiovascular or respiratory systems. The main problems in
      use were a high incidence (27%) of pain after injection, and a 10% incidence of
      significant myoclonia. In addition, 0.2 mg/kg was assessed as an inadequate
      induction dose of etomidate in unpremedicated children.

PMID- 1015240
TI  - Study of blood catecholamine levels before, during and after surgery, under
      different types of general anesthesia.

PMID- 1015241
TI  - Cerebral malformation associated with metabolic disorder. A report of 2 cases.
AB  - A clinical and neuropathological study is presented of two cases each of which
      showed neuronal heterotopia. Microgyria was also present in one case. One patient
      was suffering from a degenerative disorder affecting the white matter. The other
      was a case of Menkes' disease. It is suggested that the antenatal damage may have
      been caused by an imbalance of the maternal metabolism, the predisposing factor
      being the mother's carrier state for a metabolic defect. This is the first report
      of teratogenesis in a case of Menkes' disease. It is also noted that in this case
      there is interference with the postnatal as well as the antenatal development of
      the brain.

PMID- 1015242
TI  - Anthrax meningitis. Report of two cases with autopsies.
AB  - The authors report two cases of occupation-related anthrax meningitis; one was
      direct contamination from a diseased animal; the second was due to handling of
      bone powder imported from India. The pathological pattern of involvement of the
      meninges and brain is described and discussed.

PMID- 1015243
TI  - Sequence of morphological alterations in the nervous system of metachromatic
      leucodystrophy. Light- and electronmicroscopic observations in the central and
      peripheral nervous system in a prenatally diagnosed foetus of 22 weeks.
AB  - Light and electronmicroscopic findings are reported in a case of metachromatic
      leukodystrophy diagnosed prenatally who died after iatrogenic abortion during the
      23th week of gestation. The brain of this foetus was not yet myelinated while the
      spinal cord showed early, and the peripheral nerves advanced myelination. The
      onset and the degree of myelination were similar as in a normal foetus of the
      same age. Ultrastructurally there was evidence of sulphatide storage before the
      beginning of myelination. During myelination lysosomal storage material, staining
      metachromatically in acid cresyl violet preparations, appeared in
      oligodendrocytes and Schwann cells. Besides sulphatide storage material,
      prominent amounts of neutral lipids were found in oligodendrocytes. Myelin
      breakdown was encountered very seldom.

PMID- 1015244
TI  - Cerebral "radiation necrosis": vascular and glial features.
AB  - Glial and vascular abnormalities in brain, simulating intracranial neoplasia, are
      described in a patient who received radiation to the pituitary region for
      treatment of an adenoma, 13 months before death. In addition to the expected
      changes of cerebral radionecrosis, four interesting features are cited: 1.
      Diffuse hyperplasia of capillaries in the cerebral cortex with marked endothelial
      hypertrophy; 2. abundant, large multipolar bizarre cells in the perivascular
      connective tissues; 3. focal astrocytic proliferation with many cells resembling
      either Alzheimer type I astrocytes or neoplastic cells, and 4. radiation changes
      in the non-irradiated brain.

PMID- 1015245
TI  - [Soft tissue sarcomas. Diagnosis].

PMID- 1015246
TI  - [Ectopic secretion of ADH].

PMID- 1015247
TI  - [Soft tissue sarcomas. Current therapeutic and clinical aspects].

PMID- 1015248
TI  - [Liver as an inhibitor of mammary tumors in the rat].

PMID- 1015249
TI  - [Variations in the depth of dosage when using lead blocks].

PMID- 1015250
TI  - [Method of calculation for the study of dosage variation].

PMID- 1015251
TI  - [Indirect lymphogammography in otorhinelaryngologic neoplasms].

PMID- 1015252
TI  - Nucleic acids in human normal and osteoarthritic articular cartilage.
AB  - During operations on joints of patients with osteoarthritis, specimens of
      severely degenerated cartilage of the femoral head were removed and cartilage
      from knee joints taken at meniscectomy was used as control material. DNA and RNA
      concentrations were reduced in advanced osteoarthritis, while the synthesis of
      DNA and RNA was increased in relation to the number of cells in the tissue. The
      result showed that in advanced osteoarthritis the remaining chondrocytes are
      metabolically very active.

PMID- 1015253
TI  - Effect of indomethacin on fracture healing in rats.
AB  - The healing of closed, non-immobilized femoral fractures in rats was seriously
      impaired by indomethacin given orally at a dose of 2 mg/kg daily. The fracture
      haematomas were larger and disappeared later in the animals receiving
      indomethacin. Mechanical strength testing of fracture healing showed that maximal
      tensile strength, elastic stiffness and maximal bending moment between fragments
      were significantly diminished in the indomethacin-treated animals. Radiological
      examination showed a smaller amount of mineralized callus and a more pronounced
      angulation between the fragments in these animals than in the placebo-treated
      ones. Hsitological examination showed bridging between the fragments by callus
      tissue 24 days after fracture in placebo-treated animals, whereas indomethacin
      treatment was followed by histological findings resembling those seen in early
      pseudarthrosis development.

PMID- 1015254
TI  - Effect of fracture on longitudinal bone growth in rats.
AB  - The growth rate in proximal tibia and distal radius in rats was investigated by
      the tetracycline method after femoral fracture, tibiofibular fracture, and
      metatarsal fracture. Up to 1 to 2 weeks after the fracture, a higher growth rate
      was recorded on the fractured side than on the unfractured side. This effect
      occurred later after tibiofibular fracture than after femoral and metatarsal
      fracture, but was almost of the same size and about 8 per cent of the normal
      growth rate. This difference in growth rate was caused partly by a general group
      retardation compared with the normal growth rate, and partly by a local growth
      stimulation in the fractured extremity. The growth retardation was pronounced
      after tibiofibular fracture, but was insignificant after femoral and metatarsal
      fracture. The growth rate on the fractured side after the latter two types of
      fractures was higher than under normal conditions. Thirty days after all types of
      fractures, the growth rate was normal, both in fractured extremity and in other
      growth regions.

PMID- 1015255
TI  - Muscle blood flow after amputation with special reference to the influence of
      osseous plugging of the medullary cavity. Assessed by 133 xenon and histamine. An
      animal experiment.
AB  - The muscle blood flow (MBF) in rabbits subjected to amputation of the crus was
      assessed by means of 133 Xenon and Histamine. It was shown that after the
      operation the flow in the amputation stump was initially reduced. MBF in the
      stump increased more rapidly and stayed at a higher level after closure by
      myoplasty than after amputation without myoplasty, and it was still further
      stimulated after osseous plugging of the medullary cavity.

PMID- 1015256
TI  - An unusual case of subluxation of C.3-C.4.
AB  - A case is reported of spontaneous subluxation of C.3 on C.4 in a 6-year-old boy
      due to an upper respiratory infection after surgical treatment for muscular
      torticollis.

PMID- 1015257
TI  - Fracture of the first rib.
AB  - Fifteen cases of isolated fracture of the first rib are submitted. The mechanism
      of the fracture is discussed. It proved compatible with the descriptions in the
      literature, caused either by direct trauma to the shoulder, a sudden violent
      contraction of juxtacostal muscles; or else it was a chance finding, without any
      history of trauma and as such interpreted as a fatigue fracture. A case of
      Horner's syndrome complicating a fracture of the first rib is also described.

PMID- 1015258
TI  - Pelvic strength after major amputation of the sacrum. An exerimental study.
AB  - Major sacral resections up to the level of S 1 and even higher have been
      performed. This has raised the question of the degree to which such operations
      weaken the pelvic ring. Fifteen cadaver pelves, including the fifth lumbar
      vertebra, were loaded to failure, five unresected, five after resection of the
      sacrum between S 1 and S 2, and five after resection about 1 cm below the
      promontory. The weakening of the pelvic ring amounted to approximately 30 per
      cent with the former type of resection and 50 per cent with the latter. Taking
      into consideration the calculated normal load on L 5 in upright standing it seems
      safe from this study to allow patients to stand with full weight-bearing at an
      early stage postoperatively after submaximal resection of the sacrum.

PMID- 1015259
TI  - Wear of the polyethylene head of the Oscobal prosthesis.
AB  - Ten hemiarthroplasties were performed with the Oscobal (Daubenspeck) his
      prosthesis, which consists of a metal stem and a nonrotating ployethylene head.
      Five patients died 1-150 days after the operation. Signs of massive wear of the
      polyethylene head were demonstrated in four out of the five patients still alive
      16-28 months after the operation. We can therefore not recommend the Oscobal
      system for hemiarthroplasty of the hip.

PMID- 1015260
TI  - Bifurcation of the distal femur.
AB  - Bifurcation of the femur has previously b-en reported in the literature in only
      12 cases. Two more cases are added, and the etiology of this congenital anomaly
      is discussed.

PMID- 1015261
TI  - Old total rupture of the adductor longus muscle. A report of seven cases.
AB  - Seven cases of old total rupture of the adductor longus muscle are described.
      Five patients were referred with the suspicion of a soft tissue tumour. Six
      patients reported an adequate trauma when thoroughly questioned; four of them had
      sustained the injury while playing soccer; the seventh patient could not recall
      any trauma. The diagnosis of this lesion is discussed.

PMID- 1015262
TI  - Knee instability. An orthoradiographic study.
AB  - An orthoradiographic method for preoperative assessment of mediolateral
      instability and varus/valgus deviation in gonarthorsis is presented. A special
      definition of the varus/valgus deviation is given. The examination technique has
      been tested on 15 young, healthy subjects with no clinical signs or symptoms in
      their knee joints. To test the accuracy of the method, seven of the subjects were
      re-examined at a later date.

PMID- 1015263
TI  - The incidence of osteochondritis dissecans in the condyles of the femur.
AB  - The incidence of osteochondritis dissecans in the condyles of the femur was
      studied in a defined population and was found to be twice as common in men as in
      women; the maximum incidence in both sexes being between the ages of 10 and 20.
      The site of the lesion in the condyles did not differ between age groups. The
      indicence of diagnosied cases has increased somewhat in recent years but only in
      men. The incidence in the population is less than has been suggested in the past.

PMID- 1015264
TI  - Strontium-85 uptake in knee joints with osteochondritis dissecans.
AB  - The uptake of Strontium-85 in the distal end of the femur and in the immediate
      vicinity of the lesion was measured in 12 young ment with ostoechondritis
      dissecans. The uptake was significantly but only slightly increased. It was
      confined to the area of the lesion, was less than observed in early cases of
      gonarthrosis and an order of magnitude less than in cases of osteonecrosis. It is
      concluded that the repair process of osteochondritis dissecans is very slow and
      involves only minor part of the bone tissue surrounding the lesion.

PMID- 1015265
TI  - Distal disinsertion of the patellar ligament combined with avulsion fractures at
      the medial and lateral margins of the patella. A case report and an experimental
      study.
AB  - A 12-year-old boy presented with a proximally retracted patella 5 months after an
      injury to the left knee. The clinical and radiographic features and the findings
      at operation led to the conclusion that the original lesion had been a distal
      disinsertion of the patellar ligament combined with avulsion fractures at the
      medial and lateral margins of the patella, produced by the medial and lateral
      longitudinal patellar retinacula. Loading experiments on amputation and cadaver
      specimens showed that these retinacula, apart from being tendons for the vastus
      medialis and the vastus lateralis, respectively, constitute a direct fibrous
      connection of considerable strength between the patella and the tibia and thus
      are capable of producing avulsion fractures.

PMID- 1015266
TI  - [Indications for Knowles pinning in femoral neck fractures].

PMID- 1015267
TI  - [Importance of the small trochanter in reduction of pertrotrochanteric
      fractures].

PMID- 1015268
TI  - [Mechanical complications of condylo-cephalic nailing with Kuntscher's curved
      nail].

PMID- 1015269
TI  - [Ender's nailing. Practical ideas derived from its experimental study].

PMID- 1015270
TI  - [Our experience with the Ender technic of fascicular nailing of high femoral
      fractures].

PMID- 1015271
TI  - [Preliminary impressions of use of the Ender technic].

PMID- 1015272
TI  - [Treatment of fractures of the trochanteric region by Ender nailing. Results of a
      continuous series of 120 cases].

PMID- 1015273
TI  - [Reduction of the articular pressure of the hip by surgical lateralization of the
      greater trochanter].

PMID- 1015274
TI  - [Bilateral and symmetric thrombosis of the ulnar artery. Apropos of a case].

PMID- 1015275
TI  - [Abnormalities of the lumbosacral junction and etiology of scoliosis].

PMID- 1015276
TI  - [Goyrand-Smith fractures in adults. Apropos of 32 cases].

PMID- 1015277
TI  - [Treatment of osteochondritis dissecans of the knee].

PMID- 1015278
TI  - Debridement in case of gonarthrosis.

PMID- 1015279
TI  - Surgical treatment of spinal deformities resulting from neuro-muscular disorders.

PMID- 1015280
TI  - Surgical treatment of scoliosis by Harrington's method with additional transverse
      traction and stabilization.

PMID- 1015281
TI  - [Comparative study of acoustic trauma caused by blasts, treated by vasodilators
      or by a combination of vasodilators and hyperbaric oxygenation].
AB  - The authors had comparated two series of patients with noise induced hearing loss
      treated by vasodilatators or vasodilatators and hyperbaric oxygen. This therapy
      seems to give better results than the vasodilatators only, but the patients had
      to be treated before ten days after the noise exposition. In the two series of
      acoustic trauma we see rarely a complete recovery from the hearing loss.

PMID- 1015282
TI  - [Clinical aspects of choanal atresia].
AB  - Clinical examination was performed on 10 patients with recently treated choanal
      atresia, 8 unilateral and 2 bilateral cases. All patients showed an asymmetrical
      facial skeleton, which could be classified as hemifacial microsomia, although
      sometimes in a rather subclinical form. In all unilateral cases of choanal
      atresia hypoplasia of the facial skeleton was manifest on the affected side.
      These cases did not reveal that choanal atresia can occur without any abnormality
      in the facial skeleton. Hemifacial microsomia is not only a clinical entity, but
      also has a distinct pathogenesis. In early embryonic development a trauma occurs
      in the first or second branchial arch, which causes focal mesenchymal
      destruction, and this is thought to present the pathogenesis of hemifacial
      microsomia. Choanal atresia did not always occur with associated orthodontic
      abnormalities. Clinical examination, however, revealed transversal maxillar
      compression at the affected side in three out of eight unilateral cases.

PMID- 1015283
TI  - [Ceruminoma. Apropos of a case of ceruminal adenoma of the middle ear].
AB  - Ceruminoma is a rare form of tumor in man. Most of them are found in the external
      ear, rarely in the middle ear. The authors review the relevant literature and
      report a case of ceruminal adenoma arising in the middle ear. The prognosis of
      these tumors is relatively bad because of their potential malignancy and the
      tendency for recidivation. Recommendations for treatment are deep excision,
      postoperative irradiation in malignant types and regular follow-up visits.

PMID- 1015284
TI  - [Latero-cervical branchial cysts and fistulas].
AB  - Twenty-four cases of cysts and fistulae of the lateral part of the neck are
      presented. They come from the very important modification in the branchial
      apparatus arising during the embryogenesis of the neck. We found these vestigal
      anomalies moreover under the mandibula before the sterno-cleido-mastoidean
      muscle, but every where in the lateral part of the neck too. The differential
      diagnosis must be done between lymph nodes infections, dermoid cysts, benign and
      malignant tumors. Therefore the puncture seems very contributive. The best
      therapy is for everybody the radical removal.

PMID- 1015285
TI  - [A simple method of myringoplasty].

PMID- 1015286
TI  - [Histopathologic study of tympanoplasty].

PMID- 1015287
TI  - [2 cases of cerebrospinal otorrhea].

PMID- 1015288
TI  - [Significance of the fusospirillum complex (Plaut-Vincent angina)].
AB  - The results are discussed of a retrospective study of 126 patients by whom an
      excess of the fusospirochaetal complex was found by direct microscopic
      examination of tonsillar material. These bacteria are not only found in
      unilateral ulcero-necrotic tonsillitis, but also in different other tonsillar and
      general diseases. Vincent's angina appears almost exclusively in young persons,
      aged from 16 to 25 years; in the adolescence (16-20 years) it forms about 40% of
      all cases of acute tonsillitis. The fusospirochaetal complex is also often found
      in chronic tonsillitis and even in morfologically normal tonsils, especially in
      patients with general diseases like rheumatic arthritis. In one third of the
      patients with infectious mononucleosis, the complex is present in the tonsillar
      lesions. The occurrence of Vincent's angina is double as high in women than in
      men. From our assessments we can conclude that the fusospirochaetal complex has a
      very low pathogenity, and that it only can grow in patients with a reduced local
      or general resistance, even without causing local lesions.

PMID- 1015289
TI  - [Calender of congresses, courses, meetings of otorhinolaryngology and related
      sciences].

PMID- 1015290
TI  - Familial hypoplastic left heart syndrome.

PMID- 1015291
TI  - Pulmonary artery pressure changes in infants with bronchiolitis.

PMID- 1015292
TI  - Levamisole therapy for cellular immunologic deficiency with high IgE values.

PMID- 1015293
TI  - Scintigraphic diagnosis of subdural collections in children: improved accuracy
      with delayed imaging.

PMID- 1015294
TI  - Neonatal Coxsackie B3 sepsis.

PMID- 1015295
TI  - Reye's syndrome: much work remains to be done.

PMID- 1015296
TI  - 3H-Thymidine labeled mast cells in mice treated with 20-methylcholanthrene:
      proliferation of precursor cells, their transformation into mast cells and
      migration of the latter.
AB  - In an attempt to clarify the kinetics of increase of mast cells, autoradiographic
      studies were performed on the mice which received a painting of 20
      methylcholanthrene on the skin. In the first experiment, mice received 20
      methylcholanthrene painting on their back for two, four and eight weeks. A fourty
      eight hours' cumulative labeling with 3H-thymidine was performed directly before
      sacrifice. No labeled mast cells were found in the painted skin, despite a marked
      increase of mast cells in number. In the second experiment, mice received 20
      methylcholanthrene painting for thirty-one days. A twenty-four hours' cumulative
      labeling was performed three, five, seven, fourteen, twenty-one and thirty-one
      days before sacrifice. A high labeling index of mast cells, up to 61.29%, was
      obtained in each group. When the time lapse between the time of cumulative
      labeling and the sacrifice is long, the labeling index is higher in the
      subcutaneous tissue, and when the time lapse is short, the labeling index is
      higher in the subepidermal tissue. From these results it was concluded that; 1)
      An increase of mast cells is due predominantly to the proliferation of precursor
      cells and their transformation into mast cells. 2) The proliferation of precursor
      cells occurs mainly in the subepidermal layer of the skin. 3) After the
      transformation, mast cells may migrate into the deeper layer of the skin.

PMID- 1015297
TI  - Sarcoma botryoides arising from the biliary tract of children. A case report with
      review of the literature.
AB  - Sarcoma botryoides (embryonal rhabdomyosarcoma) originating from the common bile
      duct is reported in a 4-year-old girl. Grossly, the tumor is characterized by
      multiple polypoid and grape-like projections into the lumen of the common bile
      duct and shows plate-like thickening of the common bile duct wall. On multiple
      cut-sections these polypoid masses are soft and light yellow white except for
      multifocal hemorrhage. Histologically the tumor consists of undifferentiated
      mesenchymal cells with a myxomatous appearance; rhabdomyoblasts with varing
      degree of maturation are scattered here and there within the matrix. These cells
      are characterized by a strap and racket shape with abundant eosinophilic
      cytoplasm and elongated cytoplasm with cross striations. The histogenesis of the
      tumor may be related possibly to an abnormal differentiation of the primitive
      mesenchymal cells toward striated muscle cells.

PMID- 1015298
TI  - Histopathology of Behcet disease. Review of the literature with a case report.
AB  - An autopsy case of Behcet disease which was considered to be typical both
      clinically and histopathologically was reported. Cerebral abscess was also noted.
      Consequently it was presumed that some of the findings which had been called
      softening, demyelination, cavitation among others as the lesions of Neuro-Behcet
      might be closely related to abscess. Besides suppurative endoaortitis which was
      thought to be of interest as the lesions of Vascular-Behcet was observed. In
      order to substantiate the above, a general review of the literature of Behcet
      disease was made.

PMID- 1015299
TI  - Disturbances in the electrical and contractile gastric activities after bilateral
      transthoracic vagotomy.
AB  - Experiments were made on four dogs with chronically implanted electrodes. Fistula
      according to Bassov was made in one of the animals, and in each of the remaining
      three - two semiconductor silicon tensotransducers were sewn to the gastric wall.
      Bilateral transthoracic vagotomy results in inco-ordination between the rhythm of
      slow potentials generation from the body and from the antrum of the stomach. Slow
      potentials and contractions with frequencies usual for the stomach are recorded
      from the body of the stomach, while in the antrum there appear from time to time
      bursts of slow potential groups with relatively high frequency. These groups are
      not followed by contractions of the stomach wall or by changes in the
      intragastric pressure. Bilateral transthoracic vagotomy leads to disturbances in
      the conduction of the slow potential generated in the proximal segments of the
      stomach, as well as to distrubances in the propagation of the peristaltic wave.

PMID- 1015300
TI  - Character of the mechanical activity of the various sections of the complex
      stomach upon vagal stimulation.
AB  - The experiments are carried out on chloralose-anaesthesized sheep (50-70 mg/kg).
      The increase in the force, frequency and duration of the stimulating impulses in
      a geometric progression leads to an increase in the amplitude of the contractions
      in all sections of the complex stomach. The amplitude and nature of the evoked
      contractions for one and the same parameters of stimulation are different in the
      different sections. The latency of the response in the reticulum is always
      shorter and its contractions increase faster than in the other sections. The
      relaxation of the muscles after elimination of the stimulation to the initial
      level is slowest in the rumen and in the case of high parameters of stimulation
      it takes more than 10 min.

PMID- 1015301
TI  - Participation of adrenergic mechanisms in the genesis of the cortical brain
      electrical activity.
AB  - The changes both in the spontaneous and in the evoked electrical activity of the
      somatosensory cortex, occurring after local or systematic administration of
      chlorpromazine, have been studied on 36 cats. The neuroleptic used weakens both
      the spontaneous cortical electrical activity and that induced by stimulation of
      n. radialis and of MRF. The potentials evoked by stimulation of VPL do not
      change. Systematic administration of chlorpromazine causes analogous changes in
      the electrical activity of the somatosensory cortex. Stimulation of n. radialis
      and MRF, though not of VPL, results in a sharp increase in the activity of the
      adenylate cyclase in the somatosensory cortex. Local administration of
      chlorpromazine leads to statistically significant less marked increase in
      response to applied stimulations of the adenylate cyclase activity. The results
      obtained substantiate the assumption that adrenergic neurones participate in the
      formation both of the spontaneous and of the induced electrical activity in the
      somatosensory cortex of cats.

PMID- 1015302
TI  - On the neurogenic vasoconstriction of the resistive vessels in cutaneous vascular
      bed--rabbit ear.
AB  - A study was made of the effect of increased sympathetic activity during bilateral
      carotid occlusion (BCO), during haemorrhage and during i.v. injection of
      Tetramethylammonium jodatum (TMAI) on the resistive vessels in rabbit ears. The
      animal was under slight urethane anaesthesia, with spontaneous respiration after
      tracheotomy and vagotomy. The ear was perfused by roller pump with constant flow
      with tempered oxygenized Tyrode solution or with blood from a donor-animal. The
      increase in sympathetic activity during BCO, haemorrhage and injection of 100
      mg/kg TMAI did not change the perfusion pressure in the perfused rabbit ear. The
      initial perfusion of the ear with blood increased the resistance of the ear,
      while perfusion with blood from donor-animal which had suffered considerable
      haemorrhage caused additional increase in the resistance by about 150 per cent.
      The effect of sympathetic constrictory influence of the resistive vessels is
      studied in view of the anatomic-functional specificities of the nerve supply of
      the ear and of the cutaneous vessels, in view of the passive dilatation of the
      resistive vessels, and of the thermoregulatory function of the ear. It is
      indicated that considerable hormonal vasoconstriction probably occurs in the
      rabbit ear during haemorrhage.

PMID- 1015303
TI  - Vascular effects upon experimental increase in the interstitial osmolarity.
AB  - Experimental increase in the interstitial osmolarity in the limb of a cat is
      caused by intraarterial infusion of hypertonic solutions. The limb was
      autoperfused with blood at a constant flow using a roller pump. Hypertonic Tyrode
      solutions with increased content of NaCl, glucose, l-ascorbic acid, with normal
      or increased KCl content, were infused together with the blood. The perfusion and
      arterial pressures were measured and the constrictory response upon local
      intraarterial injection of 0.2 mug 1-noradrenaline was determined. The
      intraarterial hypertonic infusion evoked a vasodilatatory response which was
      maintained irrespective of the reduced or preserved vascular contractility. The
      magnitude of the vasodilatation was determined by the hypertonicity of the
      solution and by the KCl content. Hyperosmolaric reduction of the vascular
      contractility was lacking in the case of solutions with increased KCl content or
      addition of l-ascorbic acid. The vasodilatation observed also when the
      contractility was not reduced is discussed in view of the participation of a
      passive vasodilatation caused by the dehydration of the vascular wall. The effect
      of the changes in the transmembrane Na+ and Ka+ concentrations on the reduction
      of the vascular contractility is also discussed.

PMID- 1015304
TI  - In vitro effect of prostaglandine F2alpha on the motility of the myometrium.
      Interactions with adrenergic and cholinergic receptors.
AB  - The in vitro effects of prostaglandine F2alpha(PGF2alpha) on the spontaneous
      contractile activity of the myometrium of rat, guinea-pig and rabbit and its
      interactions with adrenergic and cholinergic receptors were studied. All animals
      were with oestrogen domination. One myometral strip of each animal species was
      placed under identical conditions in a common bath with Krebbs solution. Each
      strip was connected to a strain gauge for the recording of the contractile
      activity. L-Noradrenaline (N) and Adrenaline (A) in doses of 10(-6) g/ml inhibit
      the contractile activity of rat myometrium (stimulation of the beta-receptors)
      and this effect is antagonized by beta-blocking agents. Conversely, N and A
      stimulate the myometrium of guinea-pigs and rabbits (stimulation of the alpha
      receptors) and this effect is antagonized by the alpha-blocking agents. Unlike N
      and A, PGF2alpha stimulates the contractile myometral activity in all three
      species and its effect is not antagonized either by adrenergic or by cholinergic
      blocking agents. The stimulating effect of PGF2alpha antagonizes the inhibitory
      effect of N and A on rat myometrium and potentiates their stimulating effect on
      the myometrium of guinea-pigs and rabbits with a noncompetitive mechanism.

PMID- 1015305
TI  - Effect of exhaustive swimming on the oxidative phosphorylation and the activity
      of some enzymes in rat liver mitochondria.
AB  - In liver mitochondria of control animals and of animals subjected to swimming for
      three hours experiments are made to determine the activities of rotenone
      insensitive NAD.H-cytochrome c-oxireductase, succinate-cytochrome c-oxireductase,
      MDH, SDH, ATP-ase and cytochrome oxidase, as well as oxygen uptake, respiratory
      control index and ADP/O ratio upon oxidation of succinate and glutamate + malate.
      Decrease of the ADP/O ratio and of the respiratory control index, as well as
      increased ATP-ase activity, are established after swimming. The e--transport rate
      decreases. The activity of the remaining enzymes is unchanged. The activities of
      MDH, SDH, NAD.H-cytochrome c- and succinate-cytochrome c-oxireductases decrease
      22 hours after exhaustive swimming. The activities of the cytochrome oxidase and
      the ATP-ase are unchanged compared with the controls. A single exhaustive loading
      results in changes in the capacity of phosphorylation in the liver mitochondria
      and the changes in the activities of the enzymes studied are established 22 hours
      later.

PMID- 1015306
TI  - Experimental study of the effects of imidazol, papaverine and histamine on
      convulsive-seizure reactivity.
AB  - In experiments on male albino rats and mice a study is made of the effects of
      imidazol which is a phosphodiesterase stimulator, papaverine which inhibits
      phosphodiesterase and histamine which stimulates adenylate cyclase, on the
      convulsive-seizure reactivity. The substances are introduced intraventricularly
      and intracerebroventricularly, imidazol also intraperitoneally in different doses
      and at different intervals before the convulsive agent. Electrical,
      pentylenetetrazol (Cor) and strychnine convulsion models are used. The effect of
      imidazol on the spontaneous cortical bioelectrical activity is studied throuth
      its i. v. administration in rabbits. Imidazol markedly increases the convulsive
      reactivity, and in large doses it alone results in electrographic and motor
      convulsions. Paperine slightly lowers the convulsive-seizure reactivity only in
      pentylenetetrazol convulsions. The results obtained and their comparison with the
      results of previous experiments of ours with other drugs affecting the cyclic
      adenosinemonophosphate (cAMP) system, such as lithium, haloperidol, caffeine and
      theophyline, do not permit to assume a considerable significance of the influence
      of these substances (in the doses tested) on the cAMP system in the mechanisms of
      their effects on the convulsive-seizure reactivity.

PMID- 1015307
TI  - Effect of the verbal instruction on the late positive wave P3 of auditory evoked
      potentials in human subjects.
AB  - The changes in the late positive wave P3 of the averaged evoked potentials (AEP)
      are studied under conditions when: (a) only high tones were presented requiring
      no motor response; (b) only low tones were presented requiring motor response;
      (c) the subject was instructed that the two types of tones will be presented in
      random order with a definite probability (50%:50% or 25%:75%, or conversely
      75%:25%) requiring motor response only to the low tones. In fact, however, only
      high tones were presented to which no motor response was required (pseudo-mixed
      series). It has been established that under the effect of the verbal instruction
      used, the P3 wave of the AEP of the pseudo-mixed series increased at the
      beginning of the series, and thereafter the P3 "behaviour" was different with the
      different subjects: (1) In some of them P3 persisted until the presentation of a
      definite number of signals (different for the individual subjects) and afterwards
      it disappeared; (2) In some others P3 now increased now disappeared in a manner
      different for the different subjects; (3) Subjects in which P3 remained
      pronounced throughout the entire series; they also "heard" low tones. All these
      changes in P3 did not depend on the probability characteristics of the pseudo
      mixed series ascribed by the instruction. The dependence of the late positive
      wave P3 on the processes of probability prediction in the human brain
      functioning, and on the changes in the arousal, is discussed.

PMID- 1015308
TI  - Dynamics of the partial restoration of slow-wave frequency of the duodenum below
      transection.
AB  - Transection of the proximal duodenum of dogs was followed by end-to-end
      anastomosis. The electrical activity of the duodenal wall of both segments was
      recorded. On the background of decreased slow-wave frequency below the section
      single slow waves were observed with duration similar to that of the slow waves
      above the section. In the days after surgery their number increased, small groups
      of such waves appearing during and after spike activity. In some of the
      experiments from the end of the first month of the sixth month after surgery the
      slow wave frequency below the section approached the slow wave rhythm above the
      section as evidenced by the histograms. This was a temporary phenomen, which was
      partly eliminated by cholinergic and alpha- and beta-adrenergic antagonists. Such
      a phenomenon was also observed in definitively spearated distal segments of the
      duodenum. Histological examination of intestinal wall taken from the area of
      anastomosis showed on the 3rd day the presence of single smooth-muscle cells
      among the granulation tissue, filling the gap between the wound edges; on the 6th
      day the number of these cells increased and on the 9th and 12th day they formed
      small groups. From the end of the first month to the sixth month small sheaves of
      smooth-muscle cells were observed in the cicatricial tissue. It is concluded that
      the intrinsic nervous system keeps the slow wave frequency below the duodenal
      transection at a higher level than the smooth muscle cell regeneration might
      ensure.

PMID- 1015309
TI  - On the adrenergic mechanism of cerebrovascular resistance regulation.
AB  - It has been found out experimentally that there is a decrease in the pressor
      action of noradrenaline on cerebral vessels during repeated injections, which is
      probably due to the increased concentration of endogenic prostaglandins in
      response to noradrenaline administration. During inhibition of prostaglandin
      biosynthesis we have observed reverse action -- increase in noradrenaline pressor
      action and sympathetic effect on cerebral vessels. The hypothetic scheme of
      prostaglandin participation in adrenergic regulation of cerebrovascular tone is
      presented.

PMID- 1015310
TI  - Effect of the drug AS2 on the central and peripheral mechanisms of vascular tone
      regulation.
AB  - The effect of the compound AS2 (N'-benzhydryl, N''-allylpiperazine
      dihydrochloride) on the central and peripheral mechanisms of vascular tone
      regulation is studied. Six series of experiments on cats are carried out. The
      effect of the compound is tested on a model of central-hypertensive reaction, on
      the spontaneous bioelectrical activity of the renal nerve, on the transmission of
      excitation to the upper cervical ganglion and the ganglia of the solar plexus.
      Experiments are made to study its adrenolytic a-d myotropic properties.
      Cinnarizine is tested as control. The results show that the compound AS2, similar
      to Cinnarizine, affects the central and peripheral mechanisms of vascular tone
      regulation. In small doses (1-5 mg/kg) AS2 manifests poor myotropic properties.
      Administration of the drug in doses of 10-20 mg/kg results in considerable
      inhibition of the vasomotor centres, brief disturbances in the excitation
      transmission in the sympathetic ganglia and slight inhibition of adrenergic
      transmission.

PMID- 1015311
TI  - Effect of imidazole, papaverine and histamine on learning and memory in albino
      rats.
AB  - In experiments for learning of albino rats in a maze and testing of the memory 24
      hours and 30 days after learning, it was established that: Imidazole introduced
      i.p. in doses of 10, 30 and 60 mg/kg had no effect on learning, though it
      improved the memory both after administration 1 to 15 min before learning and
      when injected immediately after learning. Papaverine in doses of 2, 0.5 and 0.1
      mg/rat and histamine in doses of 0.1, 0.01 and 0.001 mg/rat, introduced
      ventricularly before learning, make learning impossible (the large doses),
      deteriorate it (the medium doses), or have no effect on it (the small doses).
      Memory also deteriorates, with the exception of the smallest histamine dose.
      Introduced immediately after learning, the large dose of papaverine deteriorates
      memory, while the small dose results in a tendency to improve the memory indices
      upon testing 24 hours after the administration. The large dose of histamine
      administered after learning has no effect, the small dose results in a certain
      tendency to improve memory when tests are made 30 days after learning. The
      results obtained and their comparison with the results of previous works of ours
      involving other drugs with a known effect on the system of the cyclic
      adenosinemonophosphate (cAMP), e.g. haloperidol, lithium, caffeine and
      theophylline (in the doses tested), do not suggest any essential role of the
      effect of these drugs on the cAMP system in the mechanism of their effects on
      learning and memory.

PMID- 1015312
TI  - Method for assessment and comparison of the average rate of development of the
      phases of the contractile process in isolated smooth muscles.
AB  - In certain methodological setups the pharmacological agent is applied in a
      flowing fluid and washes the smooth-muscle preparation for a certain period of
      time. In such cases it is possible to observe differences in the slope of the
      curves of the contractile and relaxation phases of the contraction and appearance
      of the amplitude maximum at different moments in the total duration of the
      contractile process. The recording of the average development rates of the
      contraction phases, in addition to the commonly accepted indicator of th effect
      of the amplitude maximum, could give an additional characteristic to the action
      of the pharmacological substances. A method is proposed for determination of the
      average rates of the contractile and relaxation phases, as well as the relative
      dependence between them.

PMID- 1015313
TI  - Pharmacological effect on the average rates of development of the contractile and
      relaxation phases of the acetylcholine contractile effect in the smooth muscles
      of guinea-pig caecum.
AB  - The average rates of development of the contractile and relaxation phases and
      their relative dependence in the acetylcholine contractile effect, after
      treatment with papaverine, prostaglandines E1 and F2 alpha and BaCl2, are tested
      on longitudinal and circular smooth muscles of guinea-pig caecum. Changes are
      observed in the effect on the phase rates of the contractile process caused by
      acetylcholine in the two muscles under the effect of the different drugs. In both
      muscles the relative dependence between the phase velocities is lowered by
      papaverine and raised by BaCl2. It is assumed that the interaction of the
      pharmacological substances with the calcium ions plays a role in the rate of
      manifestation of the pharmacological effect.

PMID- 1015314
TI  - Coordination between the longitudinal and circular layers of the stomach during
      the excitator-contractile process.
AB  - The coordination between the longitudinal and circular layers of the stomach
      muscle is studied using strips of cat stomach cut along the longitudinal and
      circular axis of the stomach, preserving the connection between them. The
      longitudinal muscle layer plays a leading role both with respect to the
      bioelectrical and to the contractile activity of the stomach. Under the effect of
      acetylcholine (10-7) the delay time of the circular muscle layer is shortened
      compared with the longitudinal layer (from 2.44+/-0.17 to 0.8+/-0.7 s). Under the
      effect of Ba ions not only shortening of this time is observed, but also
      inversion of the process-the circular layer becomes leading with respect to the
      contractile process in some moments.

PMID- 1015315
TI  - Duration estimation of visual light and dark stimuli.
AB  - Estimation of visual light and dark stimuli duration is studied in eight
      subjects. The intervals are within the range of 100 to 1,100 ms. Three of the
      subjects were trained with intervals presented with light stimuli, the others -
      with dark stimuli. Time intervals presented in both ways were given for
      estimation to both groups of subjects. The extimates depend on the position of
      the time intervals in the range, on the type of the stimuli with which they are
      presented and on the way of training.

PMID- 1015316
TI  - Estimation of time intervals in an array of intervals. I.
AB  - It has been shown that when man estimates the duration of separate brief time
      intervals(300-1,000ms), elements of a certain array of time intervals within the
      same range, the estimation is not affected by changes in the other elements of
      the array. The complex light and dark intervals are considerably underestimated.
      The separate estimation of two elements (light and dark interval) from the array
      has shown that the sum of the separate responses exceeds the estimation when the
      same two elements have to be estimated together as a total interval. The results
      could be explained by the existence of at least two "internal clocks".

PMID- 1015317
TI  - Mechanisms of correction in a "hit the target" task experiment.
AB  - The ability of men to change their behaviors depending on previous errors is
      studied. It is found that in a task involving pressing of a key simultaneously
      with the second of two consecutive light signals with a constant intersimulus
      interval (800 ms), the subjects altered their responses alteration depending on
      the preceding error. Using the same task but with variable intersignal interval
      (750, 800 and 850 ms) and provided the subjects did not understand that in fact
      three different intervals were presented to them, it was found that the same
      corrections were made as in the task with constant interval. The different
      subjects accepted the task differently and therefore their mean response times
      and the slope of the regression line are different.

PMID- 1015318
TI  - Changes in the late positive wave of auditory evoked potentials in simple
      reaction--time tasks.
AB  - A comparison is made of the averaged evoked potentials (AEP) to auditory signals
      obtained in three different series: (a) a series consisting of high tones only to
      which no motor response was required; (b) a series consisting of low tones only
      in which quick motor response was required; (c) a series consisting of the same
      low tones and elimination of the requirement for quick motor response. It was
      found that the late positive wave P3 of AEP changed in the different series. In
      the series requiring no motor response P3 was poorly expressed, in the series
      requiring quick motor response P3 markedly increased and in the series in which
      the requirement for quick motor response was eliminated, it decreased again. The
      AEP configuration from the last series repeated that obtained from the
      indifferent signals. Moreover, on evoked potentials to signal trials and analysis
      was made of the dispersions in the P3 latencies under conditions requiring motor
      response. Their difference was found to be insignificant. The results obtained
      are explained by the assumption that the wave P3 reflects the activity of the
      central nervous system related to evaluation of the outcome and with the result
      of the prediction and the planned speed of the motor response.

PMID- 1015319
TI  - About the human visually evoked cortical potentials in response to train
      stimulation.
AB  - Cortical potentials were elicited by means of light pulse trains delivered at
      varying number and frequencies of flashes. The stimulation trains evoked distinct
      series of individual responses up to flash interval of 35 ms, the shape of which
      was influenced by the number of the flasches in the trains. A gradual decrease of
      the second (and some later) wave in the response was observed beginning at flash
      interval of 80 ms and depending on the number of the flashes in the stimulation
      train. The fading away of the second wave at high-rate intermittent light
      stimulation is discussed in respect to some previous findings at retinal and
      cortical levels.

PMID- 1015320
TI  - Participation of bivalent ions in the acetylcholine-provoked gastric smooth
      muscle phasis contractions.
AB  - Experiments were carried out on muscle strips from cat antrum. Acetylcholine
      added to Ca++ -free medium containing EDTA (10-5M) exerted no effect on the
      phasic contractions of the gastric smooth muscle. Ba++at low concentrations (0,1
      to 0,5mM) replaced Ca++with respect to the acetylcholine effect. On the
      background of blocked cholinergic (atropine 10-5M) and adrenergic (phentolamine
      10-5 M and propranolol 10-5M) structures Ba++ provoked slow potentials and
      cotractions with a frequency of 9 to 10 cpm. delta600 (10-5M) blocked the Ba++
      induced myogenic electrical and contractile activities of the smooth muscle. The
      role of the cholinergic structures for synchronizing the electrical and
      contractile activities of the smooth muscle is considered.

PMID- 1015321
TI  - [Synthesis of derivatives of 1,2,3,4-tetrahydro-5H-(1) benzopyrano (2,3-b)
      pyridin-5-one].

PMID- 1015322
TI  - [Synthesis of s-triazine derivatives of benzimidazole].

PMID- 1015323
TI  - [Acylation of imidazoline-thiol-2, 2-carboxymethylthioimidazoline and 2
      cyanomethylthioimidazoline].

PMID- 1015324
TI  - [Search for anticholinergic agents. II. Synthesis of some spiro- and phenyl-1,3
      dioxolanes].

PMID- 1015325
TI  - [Derivatives of 4-chloro-5-sulfamylbenzoic acid. I Synthesis of 4-chloro-2
      hydrazino-5-sulfamylbenzoic acid].

PMID- 1015326
TI  - [Synthesis of 2,4'-dimethylfurane (2':3'-5:6) chromone-5'-carboxylic acid].

PMID- 1015327
TI  - [Synthesis of 9(11)-ones of androstane and pregnane series].

PMID- 1015328
TI  - [Properties of BaSO-4 in viscous media].

PMID- 1015329
TI  - [Use of irspectrophotometry in quantitative drug analysis. III. Assays of some
      steroid mixtures].

PMID- 1015330
TI  - [Assays of phosphorus compounds in the presence of arsenic compounds in medicinal
      preparations].

PMID- 1015331
TI  - [Effects of gamma radiation on some artificial blood substitutes].

PMID- 1015332
TI  - [Comparison of hypoglycemic activity of crystalline and recrystallized insulin
      preparations and their fractions].

PMID- 1015333
TI  - [Occurrence of peptides in medicinal protein hydrolysates].

PMID- 1015334
TI  - [Comparison of biological properties of 2 L-asparaginase (L-amidohydrolase)
      preparations].

PMID- 1015335
TI  - [Complexometric determination of nialamide].

PMID- 1015336
TI  - [Erythromycin polymorphism].

PMID- 1015337
TI  - [Vital contact with reality].
AB  - From the standpoint of existential phenomenology, the contact with reality lies
      in the very phocus of theory, being closely related to another basic conception:
      that of being-in-the-world. In order to ratify those conceptions, the author
      reviews some concepts imported from Kurt Lewin's Field Theory, among which: a)
      vital psychological space, embedding the subject and in close interchange with
      him; b) intrapsychic regions, having, to a certain extent, autonomous functions,
      but being related to each other and integrated into the higher unity of the
      subject. As both systems are interdependent, any modification of the equilibrium
      of one of them reverberates into the other's, and changes the general conditions
      of both of them. Reviewing, at the same time, Minkowski's views on schizophrenia,
      the author sets forth the production of an inner world that becomes autonomous
      and possesses a degree of reality that overwhelms the true outer world. There is
      not only the splitting from reality, but the creation of a whole fantastic field,
      in which the individual participates with all his vital availability. Both views
      lead to a similar contention: that in some pathological states, the primal link
      man-real world, is replaced by a new inner correspondence, focused on the
      imaginary and having effects similar to those of the real world.

PMID- 1015338
TI  - [The epistemological obstacle in the constitution of social sciences].
AB  - I. General conception. The author contends that the constitution of science
      requires the completion of two different tasks: a) a negative-critical one, i.e.
      the clearing of the theoretical field through expurgating all pre-scientific
      ideologies jeopardizing the growth of scientific concepts; and b) a positive
      constructive one, or the actual building up of a science through the production
      of the formal-abstract object, using ontically indeterminate raw material. Those
      tasks have characteristics that differ from the formal and factic-natural
      sciences to the social sciences. The reasons for the differences are: a) the
      former two have established objects, whereas the latter ones have their objects
      in the process of undergoing constitution, and thus possessing and oscillating
      ambiguity; b) the former two sciences have specific methods related to their
      specific objects, whereas the latter ones have a host of methods, all of them
      advocating scientific status; c) the former two sciences integrate their concepts
      into systems so as to constitute the unity of their meaning, whereas the latter
      ones lack a systematic integration. The consequence is that sciences already
      constituted (formal and factic-natural sciences) have, by the same token,
      established the co-implication of both moments (negative-critical and positive
      constructive), to the extent that they are in the midst of universes admitting
      some law-system. Social sciences, on the contrary, set a double register of
      problems: a) "in-themselves", as they suppose the opening of a new way to
      approach the object; and b) "for-themselves", as long as that opening is
      performed at the expense of pre-scientific ideologies that bar the developments
      to be done "in-themselves". Furthermore, the double task is not accomplished in
      the same fashion in logic-formal sciences and factic-natural ones, both groups
      having an apodictic adequation (absolute in the first group, relative in the
      second one) between the context of discovery and the context of justification, be
      it formal or experimental, whereas in social sciences there is no such
      adequation, as they are still searching and trying to establish the mutually
      foundating relationship between both contexts. II. The epistemological obstacle
      in Psychology. Psychology, belonging to the general class of social sciences, is
      subject to two kinds of epistemological obstacles: a) those stemming from "common
      sense", born and nourished in the naive, day-to-day experience, and being used as
      a general canon for usual as well as entirely new situations; they reach the
      status of a pre-critical "knowing", based solely on beliefs, and advocating to
      provide the grounds for our opinion on singular and general subjects; and b)
      those stemming from the "speculative discourse", understood as a system of
      notions encircling themselves and pretending to have an analogical reference to
      real objects, when analogy only actualizes objects that are absent...

PMID- 1015339
TI  - [The concept of health and disease].
AB  - 1. The author reviews some current concepts concerning the definitions and uses
      of the concepts of health and illness. Starting from the definitions in
      Psychiatry, "normality" is considered from the statistic, the normative and the
      clinical standpoints, and as a part of a continuum stretching from health to
      illness. Several approaches are analyzed, among which Wittaker's, who sets forth
      the following indicators of normality: a) self-knowledge; b) self-esteem; c) self
      security; d) capacity for giving and receiving affection; e) satisfaction of
      corporal needs; f) productivity and capacity for happiness; g) lack of tensions
      and of hipersensitivity. 2. The concept of illness as an operative concept is
      also analyzed, leading to the following statements: a) it is inexistent in non
      biological sciences; b) it appears in social sciences only through extrapolation;
      c) in medicine it means the breacking of homeosthasis; d) in psychology and
      dynamic psychiatry it means the abnormal stressing of normal mechanisms, common
      to all persons. 3. The concept of health as equilibrium is also analyzed, with
      the following precisions: a) equilibrium is defined within a system as affecting
      the whole of it, and implying transformation and self-regulation; b) homeosthasis
      is a case of equilibrium for steady complex systems; c) adaptation is the
      maintenance of equilibrium when there are exchanges with the evironment. 4.
      Finally, those concepts are applied to mental illness and its limits, and the
      following criteria are set forth: a) amount of anguish; b) depression related to
      its motives, intensity, persistence and frequency; c) regression to previous
      development stages; d) use of defense mechanisms in an inadequate or stereotyped
      way.

PMID- 1015340
TI  - [Teaching of mental health in Latin America].
AB  - The author contends that in order to meet Mental Health requirements in Latin
      American countries, an effort must be made in modifying the training of
      personnel, ranging from high ranking psychiatrists and specialists, to community
      leaders. He examines the current possibilities and needs and assesses the
      consequences of new training methods. Starting from a summary review of the three
      main models for Mental Health Programs: Mental Institution or Hospital, Mental
      Health Unit and Comprehensive Program, an evaluation is made of the many
      advantages of the latter. The training of personnel for the Comprehensive Program
      reflects its structure of delegations. The lower level, D5, is the whole
      population having any mental health risks. In order to prevent them, leaders at
      the D4 level must be trained, preferably among recovered patients, at the ratio
      one D4 for every 500 D5. Training and supervision of D4 leaders is made by D3
      leaders, recruited among intermediate professionals: teachers, nurses, priests,
      auxiliaries in mental health, etc. The ratio is one D3 every 20 D4. The following
      level is that of D2 leaders, in which specialists (psychologists, social
      assistants, psychiatric nurses, etc.) act on a professional basis. The ratio is
      one D2 every 4 D3. Finally, the upper level is D1, the directors of the program,
      psychiatrists having the direction, supervision and training of D2 leaders. The
      ratio is one D1 every 2,5 D2. An evaluation is made of the experience carried out
      at Santiago (Chile) where it lasted eight years, and at Cordoba (Argentina)
      during eight months. The final evaluation stresses the advantages of the system,
      which at an extremely low cost/benefit ratio provides a comprehensive covering,
      profiting by the natural health resources of the community, otherwise neglected
      in their full potential benefits.

PMID- 1015341
TI  - [Diagnosis of family relations. A clinical example].
AB  - Starting from the contention that family processes are much too complex to allow
      any direct approach, the author proposes the simultaneous use of four models.
      They are: I. A communication model. Adopting the theory of paradoxes in
      communication, it is possible to formulate in those terms any pathological issue
      of the OEdipus complex. II. An identification model. The outcome of the OEdipus
      complex implies the adoption os a system of identifications. It is possible to
      formulate any pathological structure in terms of disturbed identification
      pattern. III. A kinship model. The anthropological model of Levi-Strauss allows
      an approach to the patterns of alliances and prohibitions; it is also possible to
      read into those patterns the pathological issues of the family group. IV. A
      semiotic model. The sessions can be considered as a corpus liable to analysis
      from the theory of discourse, and of the values in it. Disturbances in the
      discourse can be related to pathological situations. All four models are applied
      to a casestudy, aiming at testing their validity and articulations. Some final
      conclusions are drawn on the usefulness of the method, both for diagnostic and
      therapeutic purposes.

PMID- 1015342
TI  - [Study and treatment of the drug addict and his family].
AB  - The addict was approached at a Hospital of a private community with the following
      working plans: a. Amission. a.1. Diagnostic individual interview. a.2. Familiar
      interview. b. Evaluation. c. Therapeutic criteria and recommendations. c.1.
      Individual psychological. c.2. Group psychological. c.3. Drug therapy
      (Psychiatric). Some general characteristics common to all patients are reviewed,
      among them: age (all patients are adolescents); vulnerability of personality and
      ego weakness; absent father; narcissistic mother; disgregation of the family and
      pathological communication among their members; unaccepted griefs; magic
      expectations on the activity of the drug. Some case-studies are summarized, and
      some conclusions are drawn, among which: a) the patient usually employs maniac
      mechanisms, leading to the omnipotent negation of the illness and the refusal of
      any treatment; b) the family grows very anxious because of the patient, and shows
      marked reluctance to accept its role in the patient's disorders; c) the therapist
      is under permanent pressure from the patient and the family; d) the therapeutic
      team obtains more results from the coordinated action than the single therapist;
      e) the institution must provide an adequate container for the anxieties of all
      people involved in a therapeutic procedure.

PMID- 1015343
TI  - [Attitudes towards alcohol in 2 groups of children 13 years of age].
AB  - Two groups of children, thirteen years of age, were given a questionnaire to
      study their attitudes towards alcohol consumption and alcoholism. The children
      belonged to two different socio-economical levels: low and high, and were
      selected at random, in the zone "Oriente" of the National Health Service, Chile.
      The analysis of answers was made along three directions: a) affective component;
      b) cognitive component; c) reactive component. The results show that children of
      low socio-economical level are more negative and rejective towards alcohol
      consumption than the others, and show more conflicts about it. Both groups
      reproduce adult patterns and opinions of their respective level. A future
      development of this type of research can be the criteria for prognosis in
      relation to early attitudes towards alcohol.

PMID- 1015344
TI  - [Pharmacological and psychosocial aspects of drug dependence].
AB  - Use and abuse of psychotropic drugs start with history, but toxicomania starts
      much later, with the discovery of morphine, in early XIXth. Century; and
      increases sharply after the 2nd. World War. The author reviews the general
      classifications of drug abuse, stressing the many differences among them, as well
      as the differences in clinical approaches to each one of them, and in criteria
      for treatment. Abuse of drugs takes many different forms roughly reduced to
      three: a) "traditional" addicts, with permanent and heavy intake of barbiturates,
      amphetamines, alcohol and narcotics; b) regular mass consumers of medicines,
      legally prescripted by doctors on grounds of unwise criteria or sheer complicity;
      c) members of the "Drug Culture" making of drug abuse a symbol of doctrinary
      social claims. Addictive drugs are classified, according to Lehmann, into three
      groups: 1. Expansive drugs: producing intense feeling and elation, according to
      three classes: a) Thrill drugs, causing an immediate deep pleasure, a jolt in the
      stomach and warm waves towards the abdomen and genitalia, with orgasmic effects;
      b) Easiness drugs, increasing energy and self-reliance and decreasing fatigue or
      ill-feelings; c) self-realization drugs, leading to deep and rich self-awareness,
      and heighted aesthetic and intellectual potential. 2. Reductive drugs: lowering
      the intensity of sensations and emotions, in three kinds: a) Releaser drugs,
      causing removal of inhibitions and production of phantasies; b) Sedation drugs,
      easing tensions and anxieties; c) Stupefying drugs, blurring all contact with the
      outer world. The author analyzes the patterns of intake, which include generally
      two or more different types of drugs, and vary in the same individual according
      to circumstances. Finally, several factors leading to addiction are considered,
      among them: biological and genetical endowment or predisposition; psychological
      conflicts or flaws; and social factors.

PMID- 1015345
TI  - [Therapeutic efficacy of tricyclic and antidepressive agents. Comparative double
      blind test of amitriptyline and mianserin (Org GB 94)].

PMID- 1015346
TI  - [Various possibilities of histological study of the ear-lobe skin in diabetics].

PMID- 1015347
TI  - [Morphological and cytochemical characteristics of the basophil cell in cultures
      of human peripheral-blood lymphocytes].

PMID- 1015348
TI  - [Clinical problems of alcoholic cirrhosis. III. Laboratory findings, reliability
      limits and sensitivity in patients with liver cirrhosis in various phases of the
      disease].

PMID- 1015349
TI  - [Clinical problems of alcoholic cirrhosis. IV. Various phases of liver cirrhosis
      and reliability limits of laboratory analyses performed in such phases].

PMID- 1015350
TI  - [Immunological changes during the treatment of chronic liver diseases with
      immunosuppressive agents].

PMID- 1015351
TI  - [Urticaria factitia tarda with qualitative changes of serum immunoglobulins and
      C3-hypocomplementemia].

PMID- 1015352
TI  - A case report including EM and DNA repair investigations in a dermatosis
      associated with multiple skin cancers: epidermodysplasia verruciformis.
AB  - This report describes the clinical, histological and electron microscopic
      observations in a 51-year-old male with epidermodysplasia veruciformis (EV).
      Cells with early signs of malignant transformation were found closely connected
      with virus infected epidermal regions. Skin cancers appeared initially on sun
      exposed areas, such as the face and ear lobes. The UV-induced DNA repair
      synthesis was therefore studied, utilizing peripheral leukocytes. The patient had
      40% lower UV-induced DNA repair synthesis than the mean of nine healthy subjects
      of the same age. These results suggest that a decrease in UV-induced DNA repair
      synthesis in combination with a possibly oncogenic viral infection may enhance
      the disposition for somatic mutations and malignant transformation in patients
      with EV.

PMID- 1015353
TI  - The postinfarction clinic in Goteborg, Sweden. A controlled trial of a
      therapeutic organization.
AB  - Since Jan. 1, 1968, a Postmyocardial Infarction Clinic has been operating in
      Goteborg, Sweden. The methods used have been presented previously in this
      journal. The present study compares 96 male postinfarction cases, 57-67-year-old,
      treated at the Postmyocardial Infarction Clinic and a random sample of 85
      patients not treated at the clinic. The mortality did not differ between the
      groups but there was a significant difference with regard to non-fatal
      reinfarction. The reasons for this are only partially explained by better control
      of accepted cardiovascular risk factors in the group treated at the clinic.
      Cessation of smoking was vigorously recommended but lipid lowering,
      antiarrhythmic or anticoagulant drugs were never used in this group. The results
      indicate that formalized management of homogeneous patient groups may achieve a
      general reduction of recurrences.

PMID- 1015354
TI  - Prognosis of patients with complete heart block or arrhythmic syncope who were
      not treated with artificial pacemakers. A long-term follow-up study of 101
      patients.
AB  - This paper reports the results of a retrospective study carried out with special
      reference to the survival rate in a series of 101 selected cases including
      patients with complete heart block (CHB) combined or not combined with Adams
      Stokes attacks and patients with arrhythmic syncope without ECG evidence of CHB.
      All these patients were treated in our Department during 1958-68, none being
      artificially paced. Twenty-seven patients were alive at the end of the follow-up,
      i,e 6-15 years after admission to this Department on account of syncopal episodes
      or CHB. The survival rate--higher in females than males--was lower in the cases
      of CHB combined with Adams-Stokes attacks than in the cases of asymptomatic CHB.
      This applied also to the instances in which a complicating disease such as
      ischaemic heart disease (IHD), hypertension, diabetes, digitalis intoxication or
      cardiac enlargement coexisted. The survival rate in the 68 cases of CHB was
      higher at one year (68%) as well as at 5 years (37%) than that reported by other
      investigators. When assessing the survival rate in cases treated with artificial
      pacemakers, it is important to study the individual case histories with special
      reference to a previous or coexisting condition such as IHD, hypertension,
      diabetes or the presence of cardiac enlargement. The present results support the
      view that the indications for treatment with artificial pacing should be wide,
      albeit that the prognosis in this series was more favourable than might have been
      anticipated from observations by others.

PMID- 1015355
TI  - Systolic time intervals in cardiac tamponade.
AB  - Systolic time intervals (STI) have been measured in three patients with cardiac
      tamponade. The left ventricular ejection time (LVET), the preejection period
      (PEP) and the ratio PEP/LVET deviated significantly from the normal values. All
      three parameters improved immediately after pericardiocentesis and aspiration.
      The total electromechanical systole changed to only a minor degree. Measurement
      of STI may be a valuable tool in the diagnosis and treatment of cardiac
      tamponade.

PMID- 1015356
TI  - Mortality pattern among initial survivors of acute myocardial infarction using a
      life-table technique.
AB  - The 5-year pattern of mortality among 475 immediate survivors of acute myocardial
      infarction (AMI) (mean age 65 years on entry) is described by a life-table
      technique. The risk of death was highest during the early part of the follow-up.
      After 3-4 years, the prognostic influence of the AMI seemed to be overshadowed by
      the age effect. Special attention was paid to the incidence of sudden death, a
      fictive elimination of which was shown to reduce the risk of death by 9-22%
      during the different years of the investigation period. The absolute number of
      sudden deaths was highest during the early part of the follow-up period but the
      relative importance of this mode of death was approximately the same during the
      entire 5-year period after the AMI.

PMID- 1015357
TI  - Removal of exogenous triglycerides in subjects with massive obesity before and
      after jejunoileal shunt operation.
AB  - The fractional removal rate of exogenous triglycerides (TG) in 12 obese subjects
      with a mean body weight of 132+/-5 kg (S.E.M.) has been studied before a
      jejunoileal shunt operation. The study was repeated postoperatively at stable
      body weights 30-54 months later. The weight loss ranged from 13 to 65 kg (mean
      weight reduction 27%). In 8 patients, 0.3-6.0 kg of skin and subcutaneous tissue
      were removed surgically for cosmetic reasons during the weight reduction period.
      Serum cholesterol fell from 220+/-8 to 141+/-11 mg/100 ml (p less than 0.001).
      The serum TG reduction was not significant, 1.80+/-0.25 before and 1.50+/-0.19
      mmol/l after operation. The fractional removal rate of exogenous TG, determined
      by the intravenous fat tolerance test (IVFTT) with the Intralipid fat emulsion,
      was not significantly changed. The IVFFT k2 value was 3.5+/-0.5%/min before and
      4.3+/-0.6 after surgery (p greater than 0.05). Previous studies have shown that a
      major part of Intralipid is removed initially in skeletal muscle. The unchanged
      fractional removal rate of Intralipid, despite the marked reduction in the amount
      of adipose tissue, supports the concept that the adipose tissue may play a minor
      role in the initial elimination of exogenous TG from the bloodstream.

PMID- 1015358
TI  - The intercorrelation of serum cholesterol, cigarette smoking and body weight. The
      Oslo Study.
AB  - A screening for coronary risk factors in 18 000 Oslo men yielded 16 525 "healthy"
      men, aged 20-49. The intercorrelation of serum cholesterol, body weight and
      cigarette smoking was found to be more pronounced than described in other
      studies. Increasing daily exposure to cigarette smoke in the order: never-smoker,
      ex-smoker, non-inhaling smoker, inhaling smoker and present non-filter smoker,
      was parallelled by increasing cholesterol levels, but not by increasing body
      weight. Daily cigarette-smokers had lower body weight and higher serum
      cholesterol values than never-cigarette-smokers, with the exception of the 20+
      cigarette-smokers who had higher serum cholesterol values and body weight than
      the never-cigarette-smokers. As regards ex-cigarette-smokers, both body weight
      and serum cholesterol tended to increase with the number of cigarettes smoked
      before quitting. Possible explanations of these findings are discussed.

PMID- 1015359
TI  - Blood levels of 3,5,3'-triiodothyronine and thyroxine: differences between
      children, adults, and elderly subjects.
AB  - The serum levels of 3,5,3'-triiodothyronine (T3) and thyroxine (T4) in children,
      adolescents, adults, and elderly subjects have been measured by
      radioimmunoassays. It was found that while the T4 levels were essentially equal
      in all age groups examined, the T3 levels were markedly different. In children
      and adolescents (1-15 years), high values were recorded; indeed, they exceeded
      the upper normal limit in adults (20-80 years). From the age of 20, the T3 levels
      remained unaltered until the age of 80, after which there was a further
      reduction, to values approaching the lower normal limit for T3 in middle-aged
      subjects. The findings emphasize that separate normal values must be established
      for different age groups, in order to avoid diagnostic misinterpretations and
      therapeutic failures.

PMID- 1015360
TI  - On the influence of concomitant food intake on sulfonamide bioavailability.
AB  - The influence of food intake on the bioavailability of a frequently used short
      acting sulfonamide, sulfaisomidine (Elkosin), has been examined in eight healthy
      volunteers. The drug was administered as a single oral dose, both on an empty
      stomach and together with a standardized breakfast. Numerous venous blood samples
      were drawn for the first eight hours after ingestion of the drug, and the
      concentration of unmetabolized sulfonamide in serum was assessed by
      spectrophotometry. The observations indicate that concomitant food intake alters
      neither absorption rate, peak concentration, time to reach peak concentration,
      elimination rate, nor total amount of sulfonamide reaching the general
      circulation. Thus, the absorption of orally administered sulfaisodimidine is not
      at all affected by concomitant intake of food. This finding contrasts with
      previous observations on some other sulfonamides, and it may signify a
      therapeutic advantage of sulfaisodimidine. In addition, the amount absorbed
      showed only a little interindividual variation. This suggests that the use of
      standardized size and interval of sulfaisodimidine dosage can be recommended. The
      present findings emphasize that conclusions about the absorption of a certain
      drug should not be derived from studies with other, albeit chemically related,
      compounds.

PMID- 1015361
TI  - Thyroid autonomy (Plummer's disease) with contralateral malignancy--mere
      coincidence?
AB  - A patient with an autonomously functioning nodule in the left lobe and a
      papillary carcinoma in the right lobe of the thyroid gland is described. Some
      evidence suggests the association to be more than coincidental.

PMID- 1015362
TI  - Variations in the relationship between the diaphysis and the epiphyses of the
      tibia.
AB  - In all 56 tibiae from Lapps and 56 tibiae from Norwegians have been studied.
      These ethnic groups represent different weight bearing situations. Variables
      expressing adaptation to non-axial loading are dealt with. The bone is mainly
      studied in the AP and the ML planes, as well as in the three dimensional space.
      The material is analyzed statistically. The distribution form is examined and the
      deviations from normality are found to be moderate. Mainly positive skewness
      occurs. Platykurtosis is found as often as leptokurtosis. The deviations from a
      standard normal distribution are not supposed to affect the results
      significantly. There is a non-systematic pattern of distribution. The variability
      is generally lower in Lapps than in Norwegians. The standard deviation shows
      highest numerical values in indices, lowest in linear variables. Systematic group
      differences, especially in similar variables, are supposed to be of greater
      importance than isolated differences. The variables giving deviations from the
      reference planes or the diaphyseal axis, show the largest and the consistent left
      right differences. In linear variables Lapps and females show lower mean values
      than males and Norwegians, respecitvely. In linear variables giving deviations
      from the reference planes, in angular variables and in indices, Lapps usually
      show the highest mean values. Lapps tend to show larger sex differences in
      variables giving deviations from the reference planes or the diaphyseal axis.
      However, the sex differences within the Lapps are small. The variations of the
      tibia are supposed to be the results of mechanical factors in bone remodelling.
      The epiphyseal-metaphyseal parts tend to have a constant shape, the adaptations
      to non-axial loading predominantly appearing in the diaphysis. The relation
      between the weight bearing line and the diaphyseal axis is discussed,
      particularly regarding the ML stability mechanism of the knee joint. The
      occurrence of torsion and its influence upon the AP and ML projected values
      regarding the relationship between the epiphyses and the diaphysis are discussed.

PMID- 1015363
TI  - [Growth of eye and orbit in chick embryo. IX. Developement of eye and skull
      origin in 3-9 day old embryos with experimental bilateral microphthalmia].
AB  - Chick embryos in which on the third day of incubation the lens of both eye
      primordia was removed, were sacrificed at the ages of 5,7 and 9 days and fixed in
      a 70 per cent alcohol solution. An analysis was made of the consequences of the
      absence of normal large eyes upon the structure and growth of the skull.
      Immediately after the operation no changes in the head mesenchyme could be
      observed, but during the next days, as growth goes on, abnormal proportions and
      dimensions develop in the anterior part of the skull. Generally, this part of the
      skull is depressed and shorter than normal; cartilages around the eye have a
      different position and smaller dimensions. A perfect symmetry is only rarely
      maintained. There seems to be a very labile balance in the skull, as may be
      deduced from the presence of a buckled interorbital septum and the deviation of
      the upper beak.

PMID- 1015364
TI  - Morphology of ovarian changes during the reproductive cycle of the house lizard,
      Hemidactylus flaviviridis.
AB  - Ovarian changes during the reproductive cycle of the oviparous wall lizard
      (Hemidactylus flaviviridis Ruppel) are described and discussed. It ovulates from
      mid-March to mid-May with a peak in April. Two eggs, one from each ovary, are
      ovulated at a time. After the breeding season is over, the ovaries are reduced in
      size. From June to third week of February they contain small pre-vitellogenic
      fillicles which start increasing in size with the approach of March when yolk
      deposition occurs rapidly. The histological details of developing the pre
      ovulatory follicles are described. Follicle cell nuclei are taken into the
      ooplasm of pre-vitellogenic follicles; they are finally absorbed before yolk
      deposition starts. Pre-ovulatory follicles show highly vascularized thecae and
      invaginations of the follicular epithelium. Follicular atresia generally occurs
      in follicles with polymorphic granulosae, in post-ovulatory ovaries. Their
      granulosa cells give rist to phagocytes which, after removing the ooplasmic
      contents, degenerate, while the theca interna cells are hypertrophied to form the
      interstitial gland cells in the walls of degenerated follicles. After ovulation,
      the granulosa cells hypertrophy to form luteal cell mass filling the follicular
      cavity. Fibroblasts which appear to arise from the thecal layer, invade the
      luteal cell mass and form septa. Blood vessels occur in the luteal cell mass. The
      possible physiological significance of corpora lutea in the wall lizard is
      discussed.

PMID- 1015365
TI  - [Directed therapy of Parkinson's disease. Clinical evaluations and
      pharmacological choice].

PMID- 1015366
TI  - [Recent findings on the olfactory acuity in epileptic patients].

PMID- 1015367
TI  - [Study on familial dyslalia and oligophrenia].

PMID- 1015368
TI  - [Meningeal carcinomatosis due to gastric neoplasia clinically silent
      (presentation of a case with an acute course of neoplastic liquoral
      pleiocytosis)].

PMID- 1015369
TI  - [Ichthyosis and spastic paraplegia in the adult].

PMID- 1015370
TI  - [Electroencephalographic and electroretinographic study of a family with Leber's
      congenital amaurosis].

PMID- 1015371
TI  - [Behcet's syndrome (apropos of a clinical case of "neuro-Behcet")].

PMID- 1015372
TI  - [2 cases of porphyria].

PMID- 1015373
TI  - [Study of a case of subacute sclerosing leukoencephalitis. Preliminary note].

PMID- 1015374
TI  - [Hemifacial and megadolichobasilar spasm. (Clinical contribution)].

PMID- 1015375
TI  - [Angiographic study of the cerebral arteries using transfemoral catheterization.
      3 years of experiences].

PMID- 1015376
TI  - [Clinical and angiographic study on a case of occlusion of the posterior cerebral
      artery].

PMID- 1015377
TI  - [Possibility of neonatal screening using the method of evoked potentials].

PMID- 1015378
TI  - [Study of the central nervous system in subjects affected by cerebral injuries of
      various origin].

PMID- 1015379
TI  - [Problems in the lateralization of electroencephalographic changes. Preliminary
      note].

PMID- 1015380
TI  - [Relationship between various verbal intelligence tests and monohemispheric
      cerebral lesions].

PMID- 1015381
TI  - [Spino-olivo-cerebello-nigral degeneration. Study of a case begining in infancy].

PMID- 1015382
TI  - [Central metabolism of dopamine and serotonin. I. Determination of cerebrospinal
      fluid levels of HVA and 5-HIAA by the probenecid test (modified)].

PMID- 1015383
TI  - [5-HIAA and HVA levels in the cerebrospinal fluid of hydrocephalic patients].

PMID- 1015384
TI  - [Studies on free amino acids in the cerebrospinal fluid].

PMID- 1015385
TI  - [Cerebrospinal fluid biochemistry and diagnosis. Part II. Clinical biochemistry
      of monoamines and amino acids. Summary].

PMID- 1015386
TI  - [Central metabolism of dopamine and serotonin. IV. Preliminary determinations of
      cerebrospinal fluid HVA and 5-HIAA in epileptic syndromes].

PMID- 1015387
TI  - Homovanillic acid and 5-hydroxyindoleacetic acid in lumbar cerebrospinal fluid of
      patients with acute cerebrovascular lesion.

PMID- 1015388
TI  - [Influence of the age, sex and civil status in Beck's inventory].

PMID- 1015389
TI  - [Automation of information programs in mental health and clinico-psychiatric
      histories].

PMID- 1015390
TI  - [The syndrome of minimal cerebral lesion].

PMID- 1015391
TI  - [Infant juvenile psychiatry: a specialized service in the organized sector of
      Asturias. Study of 200 clinical histories].

PMID- 1015392
TI  - [Psychosurgery and biological psychiatry].

PMID- 1015393
TI  - [Considerations on the WAIS in a sample group from the normal population].

PMID- 1015394
TI  - [Suicide attempted in the general hospital].

PMID- 1015396
TI  - [Psychology of simulation].

PMID- 1015395
TI  - [Ambulatory psychiatric clinic in the general hospital].

PMID- 1015397
TI  - Statistical mechanics of protein folding, unfolding and fluctuation.
AB  - Conformational fluctuations of globular proteins in the native state and the
      processes of folding and unfolding are studied from the statistical mechanical
      point of view. 1) It is pointed out that the formation of the native specific
      conformation of a globular protein is not a result of random sampling of minimum
      energy conformations. This fact provides a motivation for the study of the
      processes of folding, or the paths of folding, of proteins. The processes of
      folding and unfolding are shown to be statistical mechanical in nature. 2) The
      conformational (folding and unfolding) transitions in globular proteins are
      compared with the helix-coil transitions in polypeptides. The gradedness of the
      latter transition is shown to be due to the fact that the phenomenon is of an
      essentially one-dimensional system. The former transition is characterized
      ideally by the fact that it is of the all-or-none type. 3) A lattice model of
      proteins is introduced. "A protein molecule" is defined as a chain of
      noninteresting units of a given length on a two-dimensional square lattice. The
      copolymeric character of protein molecules is incorporated into the model by
      specificities of interunit interactions. 4) This model proved powerful for
      studying the statistical mechanical characterization of protein denaturation and
      fluctuations. The specificities of interunit interactions were shown to be the
      primary factors responsible for the all-or-none type transition from native to
      denatured states of globular proteins. 5) The model is studied by the Monte Carlo
      method of Metropolis et al., which simulates a kinetic process approximately. The
      method is shown to be a promising tool in finding the native conformation of
      proteins from their amino acid sequence. 6) A new theoretical method is developed
      to study phenomenologically the processes of protein folding and unfolding and
      the conformational fluctuations in the native state. An important role is played
      by a quantity S(H): the entropy of a protein molecule in solution in the
      conformational states with a given value of enthalpy H. Qualitative character of
      the S-H curve, such as whether it is convex or concave determines characteristics
      of the conformational  transition in a globular protein such as whether or not it
      is of the all-or-none type. 7) The concept of an ideal process of protein folding
      and unfolding is introduced and defined by three statements. The S-H curve is
      calculated for this ideal process. The curve is shown to be concave, indicating
      that the transition is of the all-or-none type. This conclusion is drawn
      essentially from the globularity and specificity of the native conformational of
      proteins. 8) Residual structures in the denatured state and conformational
      fluctuations in the native state are discussed. In order to discuss the latter,
      an independent fluctuating site model is introduced, in which it is assumed that
      there are several independent fluctuating sites, each localized in some part of
      the protein molecule...

PMID- 1015398
TI  - Oxygen transport on Mount Everest: the effects of increased hematocrit on maximal
      O2 transport.

PMID- 1015399
TI  - Influence of hemoglobin oxygen affinity on oxidation reduction state of
      cytochrome aa3 in perfused liver.

PMID- 1015400
TI  - Metabolic and electron microscopic studies post mortem in brain mitochondria.
AB  - The RCR of malate+glutamate oxidation of isolated rat brain mitochondria
      decreased with increasing duration of anoxia and it ceased completely in the 12
      hour ischemic group. After one hour of ischemic anoxia neither the respiration of
      mitochondria nor their morphology altered irreversibly. There is a strong
      correlation between the ultrastructural changes and RCR value of mitochondria,
      namely the RCR decreased proportionally with increasing number of light type of
      mitochondria. From our results we can conclude that the dense form seems to be
      the functional form, while the light mitochondrial structure is a transition to
      the non functioning homogenous type of brain mitochondria.

PMID- 1015401
TI  - Early structural changes in mitochondria in response to acute reductions in
      capillary flow.

PMID- 1015402
TI  - The application of histological analysis for the localization of tissue PO2 and
      local blood flow with the example of the glomus caroticum of the rabbit
      (Oryctolagus cuniculus).

PMID- 1015403
TI  - Diffusion of oxygen in plasma and blood.
AB  - D in fresh human plasma has been found to decrease almost linearly with total
      protein content over a wide range of concentration and to vary only +/-4% in
      normals and +/-13% in abnormals. The average values for D in normal human plasma,
      at 25 and 37 degrees C, are 1.62 and 2.18 X 10(-5) cm2/sec respectively. For
      normal human blood at 42% hematocrit, the values of D, at 25 and 37 degrees C,
      are 1.20 and 1.62 X 10(-5) cm2/sec respectively.

PMID- 1015404
TI  - Facilitated diffusion of oxygen in red blood cell suspensions.

PMID- 1015405
TI  - Measurement of diffusivity and metabolic rate of O2 and CO2 in respiring tissue.
AB  - The method described is apt to measure, at the same time, Krogh's diffusion
      constant and specific metabolic rates for O2 and CO2 in intact, respiring
      tissues. Due to metabolism tissue thickness for this method is limited to about
      500 mum unless hyperbaric conditions are used. The results suggest that both KO2
      and KCO2 are similar in alive and in dead tissue. Due to tissue inhomogeneity and
      to possible facilitation of O2 or CO2 transport our values of K have to be
      considered as effective mean values for the physiological range of PO2 and PCO2
      in muscle at rest and at exercise.

PMID- 1015406
TI  - Facilitated diffusion of CO and oxygen in the presence of hemoglobin or
      myoglobin.

PMID- 1015407
TI  - Measurement of diffusion parameters with noble metal electrodes.

PMID- 1015408
TI  - A generalized advancing front model describing the oxygen transfer in flowing
      blood.

PMID- 1015410
TI  - The mechanical basis for Fick's law and its generalizations.

PMID- 1015409
TI  - Some model results on hemoglobin kinetics and its relationship to oxygen
      transport in blood.

PMID- 1015411
TI  - A stochastic model for the transport of oxygen to brain tissue.
AB  - Material balances around a small, but finite volume element have formed the basis
      for previous mathematical models describing the transport of oxygen in the brain
      microcirculation. Seeking a model which would be both simple and versatile, a
      stochastic model was proposed based on the assumption that oxygenation of the
      brain can be described quantitatively by simulating the activity of only one
      erythrocyte and the oxygen molecules surrounding it. Compared with existing
      deterministic models, the capillary space-average oxygen partial pressure
      profiles were in close agreement. Tissue tensions were decidedly different.

PMID- 1015412
TI  - Models for O2 and CO2 transfer in macroscopic flow channels and their
      physiological implications.

PMID- 1015413
TI  - A method for simultaneous measurements of bioelectric activity and local tissue
      PO2 in the CNS.

PMID- 1015414
TI  - Monitoring of PO2 in human blood.

PMID- 1015415
TI  - Theoretical and experimental aspects of brain tissue oxygenation dynamics.

PMID- 1015416
TI  - Local tissue PO2 and microflow of the brain cortex under varying arterial oxygen
      pressure.

PMID- 1015417
TI  - An analysis of ion distribution in brain following anoxia.

PMID- 1015418
TI  - Comparison of oxygen tension in the spinal cord and globus pallidus during
      hyperbaric oxygen exposure of rats under pentobarbital anesthesia.

PMID- 1015419
TI  - Autonomic and pharmacological control of oxygen autoregulation mechanisms in
      brain tissue.
AB  - The effect of several agents active on autonomic nervous system functions was
      tested on brain oxygen autoregulation parameters. It was found that atropine,
      propranolol and isproterenol had no influence on the measured parameters.
      Phenoxybenzamine, tolazoline and dibenamine all suppress autoregulation. In an
      additional experimental series, a phenoxybenzamine infusion was given during O2
      breathing. The infusion induced a marked rise in TpO2. It is concluded that an
      alpha-adrenergic mechanism is part of the autoregulation process, and its
      pharmacological blockade could be used to raise TpO2 levels in brain with O2
      breathing at normal atmospheric pressure. Also, the increase in brain TpO2
      induced by 95% O2 - 5% CO2 breathing seems to be blocked by alpha-adrenolytic
      drugs.

PMID- 1015420
TI  - Oxygen supply to the open rabbit cornea.

PMID- 1015421
TI  - A new approach to the experimental measurement of mean tissue PO2.

PMID- 1015422
TI  - Studies on retinal oxygenation.

PMID- 1015423
TI  - The O2 supply of the isolated cell-free perfused rat kidney.

PMID- 1015424
TI  - Effect of vasopressors and hemorrhage on intrarenal oxygenation.

PMID- 1015425
TI  - Renal tissue oxygenation during hypoxic hypoxia.
AB  - No evidence was found to support the existence of changes in the intrarenal flow
      pattern among the different areas or of a compensatory redistribution of
      microcirculation in the renal cortex under hypoxia induced by breathing 10 %
      oxygen. It seems that under these conditions the kidney is able to preserve its
      basic metabolism by diminishing its oxygen consumption.

PMID- 1015426
TI  - Corneal oxygen supply conditions.

PMID- 1015427
TI  - Cellular oxygen concentration.

PMID- 1015428
TI  - Pulmonary tissue oxygen requirement.

PMID- 1015429
TI  - Oxygen delivery and utilization in hypoxic dogs made acidemic and alkalemic.

PMID- 1015430
TI  - Evidence against local control of intestinal tissue oxygenation by myogenic
      mechanisms.

PMID- 1015431
TI  - Effect of ionizing radiation on liver microcirculation and oxygenation.
AB  - Platelet aggregation and adhesiveness, as well as TPO2 responses to hypoxia were
      measured as microcirculation parameters in beagle dogs subject to Co60 ionizing
      radiation to a dose of 4600 rads in 5 weeks. Simultaneously, changes in blood
      chemistry and coagulation were also determined. Marked changes in all studied
      parameters in the post radiation period lead to the conclusion that radiation
      liver damage is at least in part mediated through microcirculation disturbances.

PMID- 1015432
TI  - A factor in lingitudinal tissue gradients: red cell carriage.

PMID- 1015433
TI  - Effects of dopamine and epinephrine on intestinal blood flow and oxygen uptake.

PMID- 1015434
TI  - Kryomicrophotometry as a method for analyzing the intracapillary HbO2 saturation
      of organs under different O2 supply conditions.

PMID- 1015435
TI  - Solution of the diffusion field equation of substrate concentration in the
      intercapillary region considering the decrease in substrate consumption in the
      unsaturated region of cancer cell glycolysis and respiration.

PMID- 1015436
TI  - Computation of glucose and O2 concentration distribution in the intercapillary
      region of intact tumor tissue considering the decrease in substrate consumption
      in the unsaturated region of cancer cell glycolysis and respiration.

PMID- 1015437
TI  - Mesenchyme theory on the increase in resistance experienced during repetition of
      cancer therapy processes.

PMID- 1015438
TI  - Studies on the ability of the tumor respiration in vivo to fulfill its
      physiological functions.

PMID- 1015439
TI  - Oxygen distribution in tumours: influence on cell proliferation and implications
      for tumour therapy.

PMID- 1015440
TI  - Preliminary observations of oxygen levels in microcirculation of tumors in C3H
      mice.

PMID- 1015441
TI  - The distribution of oxygen consumption rates in some tissues before and after x
      irradiation.

PMID- 1015442
TI  - Mechanisms of circulation metabolism coupling in skeletal muscle.

PMID- 1015443
TI  - Spontaneous oscillations of PO2 in muscle tissue.

PMID- 1015444
TI  - Tissue PO2, VO2, venous PO2 and perfusion pressure in resting dog gracilis muscle
      perfused at constant flow.

PMID- 1015445
TI  - Tissue blood flow and oxygenation during large vessel surgery.

PMID- 1015446
TI  - Mechanisms of increased tissue oxygen delivery following release of arterial
      occlusion in canine skeletal muscle and skin.

PMID- 1015447
TI  - Mean myoglobin oxygen tension during exercise at maximal oxygen uptake.

PMID- 1015448
TI  - Oxygen transport in skeletal muscle: capillary geometry in longitudinal section.

PMID- 1015449
TI  - Control of electrode aging by a periodic anodization technique.

PMID- 1015450
TI  - The measurement of myocardial microflow and its reaction to hypoxia and
      hypercapnia.

PMID- 1015451
TI  - Oxygen uptake of the guinea pig at decreased and increased maternal placental
      blood flow.

PMID- 1015452
TI  - Fetal and placental O2 consumption and the uptake of different metabolites in the
      ruminant and horse during late gestation.

PMID- 1015453
TI  - Continuous PO2 and heart rate recording in the human newborn.

PMID- 1015454
TI  - A comparison of transcutaneous and arterial PO2 in sick neonates.

PMID- 1015455
TI  - Effect of umbilical artery catheters on oxygen supply to extremities.

PMID- 1015456
TI  - Oxygen fields induced by recessed and needle oxygen microelectrodes in
      homogeneous media.
AB  - Computer simulations of the operation of both the recessed and conically-shaped
      needle type microelectrodes were developed. The accurate portrayal of their
      geometries was greatly facilitated by the use of specialized three dimensional
      orthogonal coordinate systems with coordinate surfaces coincident with the
      geometry of the problem. From the simulations, calculations were made of the
      induced PO2 fields, oxygen sensitivities, stirring artifacts, measurement errors,
      and time constants.

PMID- 1015457
TI  - The influence of MgCl2 on the O2-Hb-binding curve of human hemoglobin under
      intracellular conditions.

PMID- 1015458
TI  - [The onset and character of menstruation in Bulgarian girls].

PMID- 1015459
TI  - [The problem of sex differences in mental capacity].

PMID- 1015460
TI  - [Incest].

PMID- 1015461
TI  - [Systemization of individual curves of handedness development].

PMID- 1015462
TI  - [15-year follow-up of a total ileo-ureteroplasty].

PMID- 1015463
TI  - [Urologic septicemia. Importance of surgical treatment].

PMID- 1015464
TI  - [Surgical treatment of 40 old bilharzial lesions of the ureter and the bladder].

PMID- 1015465
TI  - [The new Iglesia resectoscope with continuous aspiration and irrigation].

PMID- 1015466
TI  - [A rare tumor of the bladder].

PMID- 1015467
TI  - [Comparative clinical study of ampicillin and sodium cephapirin].

PMID- 1015468
TI  - [Urinary problems masked by sigmoiditis].

PMID- 1015469
TI  - [Polyorchism].

PMID- 1015470
TI  - [Crypto-Y-gonosomial azoospermia (male, 46 XX)].

PMID- 1015471
TI  - Intra-articular treatment of arthritis in race-horses with sodium hyaluronate.

PMID- 1015472
TI  - Toxoplasmosis in sheep. Toxoplasma gondii in muscular tissue, with particular
      reference to dye test titres and haemoglobin type.

PMID- 1015473
TI  - Toxoplasmosis in sheep. The relative importance of the infection as a cause of
      reproductive loss in sheep in Norway.

PMID- 1015474
TI  - Toxoplasmosis in sheep, the reliability of a microtiter system in Sabin and
      Feldman's dye test.

PMID- 1015475
TI  - Toxoplasmosis in sheep. The prevalence of toxoplasma antibodies in lambs and
      mature sheep from different parts of Norway.

PMID- 1015476
TI  - Single cell protein in the diets of pigs and chickens. Effects on the activity of
      DNASE in intestinal contents.

PMID- 1015477
TI  - Studies of transferrin polymorphism in Swedish cattle using agarose gel
      electrophoresis.

PMID- 1015478
TI  - An improved bacteriological method for the detection of sulfonamide residues in
      food.

PMID- 1015479
TI  - Vaccination of pigs against hog cholera (classical swine fever) with a detergent
      split vaccine.

PMID- 1015480
TI  - 5 alpha-androstenone and testosterone in peripheral plasma of the boar during and
      following copulation.

PMID- 1015481
TI  - Pasteurellosis in reindeer in northern Norway. A contribution of its
      epidemiology.

PMID- 1015482
TI  - A comparison of serum concentrations of penicillin after intramuscular injection
      and subcutaneous and deep injection into the dewlap in cattle.

PMID- 1015483
TI  - Heat stable nuclease in mastitic milk.

PMID- 1015484
TI  - Chemotherapy of helminthiasis among wild mammals. II. Baylisascaris transfuga
      (Rudolphi, 1819) Sprent, 1968 infection of polar bear.
AB  - Effective chemotherapy by Mebendazole of Baylisascaris transfuga infection of
      five polar bears is reported and a control measure programme directed towards
      limiting the infection under the prevailing condition is discussed.

PMID- 1015485
TI  - [Myobiiae parasites of rodents, Insectivora and Chiroptera (Acarina:
      Prostigmata)].
AB  - The author studies a collection of myobiid mites parasitic on rodents,
      insectivores and bats. This material contains 15 species, amongst them 7 species
      and 2 subspecies are new and are described for the first time.

PMID- 1015486
TI  - Further observations relating to Trixacarus (Caviacoptes) Caviae Fain, Hovell and
      Hyatt, 1972 in guinea-pigs (Acarina: Sarcoptidae).
AB  - Three cases of sarcoptic mange in guinea-pigs were found to be due to Trixacarus
      (Caviacopties) caviae FAIN et al. The history and lesions of each case are
      described together with a method of treatment.

PMID- 1015487
TI  - [New parasitic Acarina of the superfamily Listrophoroidea (Astigmates)].

PMID- 1015488
TI  - [Pericentric inversion of chromosome 3, homozygote and heterozygote, and
      centromeric translation of chromosome 12 in a family of orangutangs. Evolutionary
      implications].
AB  - An orangutang family is reported in which the father (Piku) is homozygous for a
      pericentric inversion of chromosome 3 and heterozygous for a structural
      rearrangement of chromosome 12 (author's nomenclature for this species). The
      latter is interpreted as transposition of the centromere by insertion into band
      q213 [in cen (12)(q213)]. Piku's mate has a normal female chromosome complement.
      His daughters by this mate (Agnes and Ursula) are heterozygous for both his
      rearrangements.

PMID- 1015489
TI  - Yersiniosis in the Bristol Zoo (1955-1974).
AB  - Ninety one cases of Yersiniosis occurred betwen 1955 and 1974 at Bristol Zoo.
      Species affected included a range of primates and birds, a rodent (Capybara) and
      a carnivore (Caracal Lynx). The incidence of the disease was highest in the
      winter months. There were variations in the annual incidence of Yersiniosis, with
      peaks occurring at intervals of 4-6 years. Common pathological findings included
      miliary focal necrosis and abscess formation.

PMID- 1015490
TI  - [Simple method for approximate and comparative calculation of the reserve mass in
      live snakes].

PMID- 1015491
TI  - Hemoccult detection of fecal occult blood quantitated by radioassay.
AB  - Results from the quaiac slide or Hemoccult (HO) test for fecal occult blood were
      compared with quantitative determinations of gastrointestinal loss after
      intravenous administration of 51Cr-labeled red cells. Subjects were 80
      consecutive patients, without dietary restriction, who were referred because of
      clinical suspicion of gastrointestinal blood loss or complex anemia. A total of
      555 stool specimens analyzed for 51Cr loss were graded negative, trace, or
      positive by the HO method. Of 338 specimens containing 0-2 ml/day by isotope
      assay, 7.4% were positive to the HO qualitative test. Loss of at least 10 ml/day
      in 51Cr equivalent was necessary to assure that the majority of HO reactions
      would be positive. Of specimens containing more than 30 ml/day, 93% were
      positive. The ratio of 51Cr-labeled red cell equivalents to stool volume and the
      percentage of positive HO reactions increased together. When this ratio exceeded
      10%, two thirds of the HO responses were positive.

PMID- 1015492
TI  - Influence of pregnancy on the development of various gastric lesions in rats.
AB  - The influence of pregnancy, and to some extent lactation, on various gastric
      lesions in rats were studied. Shay ulceration and gastric lesions induced by cold
      restraint stress and ulcerogenic agents, such as acetylsalicylic acid (ASA),
      reserpine, or epinephrine, in rats were significantly aggravated by pregnancy
      (day 20 of pregnancy). Gastric hypersecretion, which was observed during
      pregnancy in pylorus ligation preparation, appears to contribute to the mechanism
      of aggravation of gastric lesions. ASA induced a marked back-diffusion of acid in
      pregnant rats which might resulted in the aggravation of ASA-induced gastric
      lesions. In contrast, histamine-induced gastric lesions were markedly inhibited
      according according to the progress of pregnancy but after 10 days' lactation
      returned to the level seen in nonpregnant rats. The histaminase inhibitor
      aminoguanidine strongly aggravated the histamine-induced gastric lesions in
      pregnant rats as compared with the non-pregnant ones.

PMID- 1015493
TI  - Inhibition of water absorption by ricinoleic acid. Evidence against hormonal
      mediation of the effect.
AB  - In three dogs, each with a jejunal and an ileal Thiry-Vella loop, the isolated
      segments were perfused with isotonic electrolyte solutions (control) for 90 min.
      One loop was then perfused with 5mM ricinoleic acid for an additional 90 min,
      while the other loop was perfused with the control solution. Loops perfused with
      ricinoleic acid all showed reduced fluid absorption. Perfusion of one loop with
      ricinoleic acid produced no changes in fluid absorption from the loop perfused
      with the control solution. In other experiments, 4 Ivy dog units (IDU) per kg per
      hr of cholecystokinin (CCK) produced no change in water movement in loopd
      perfused with control solution or recinoleic acid. These experiments suggest that
      the effect of ricinoleic acid on intestinal water transport is not mediated
      through the release of a circulating humoral substance.

PMID- 1015494
TI  - Effect of chronic antacid ingestion on serum gastrin and gastric secretion.
AB  - Basal gastrin and acid secretion, and histamine- and food-stimulated acid
      secretion were examined before and after 6 weeks of regular antacid consumption
      by 20 normal volunteers, in order to test the hypothesis that regular use of
      antacids produces gastrin cell hyperplasia, altered gastrin inhibition by acid,
      and gastric hypersecretion. We found no differences in fasting serum gastrin,
      basal or maximal histamine-stimulated acid, or acid output in response to a
      protein meal after consumption of commercial antacids with or without calcium
      carbonate. The results suggest that normal subjects do not acquire functional
      hyperactivity of the gastrin mechanism after a period of regular antacid use.

PMID- 1015495
TI  - Leukoplakia of the anal canal.
AB  - Two cases of leukoplakia of the anal canal are presented, with illustrations of
      the typical gross and microscopic appearance. The lesions were asymptomatic, and
      were discovered by routine rectal examination. Histological findings included
      hyperkeratosis and acanthosis extending cephalad from the anal verge to the
      dentate line. Followup after 3 and 15 years revealed no evidence of dysplastic
      changes, and a review of the literature did not uncover any reported cases with
      dysplasia or with documented evolution to malignancy. There is little evidence
      that leukoplakia of the anal canal is premalignant but patients should be
      followed carefully, since the natural history of this rare lesion is unknown.

PMID- 1015496
TI  - The role of metoclopramide in peroral jejunal biopsy: a controlled randomized
      trial.
AB  - Metoclopramide is known to enhance gastric emptying and stimulate duodenal and
      small-intestinal peristaltic activity. The effect of the drug on peroral jejunal
      biopsy was examined in a controlled, double-blind, randomized trial. Forty-nine
      patients (24 females and 25 males) who required jejunal biopsy for diagnostic
      purposes were admitted to the study. All the biopsies were performed by the same
      operator using the Quinton multipurpose suction biopsy tube and applying the same
      technique. Twenty-four patients ranging in age from 18 to 67 years (mean 44.5)
      received placebo intravenously (sodium metabisulfite), and 25 patients from 16 to
      73 years old (mean 39.9) received 10 mg of metoclopramide intravenously prior to
      the jejunal intubation. Objective parameters of the study were (1) time in
      minutes required for the intubation at the biopsy site, ie, the area at the
      ligament of Treitz, and (2) fluoroscopy time. Intubation time in the placebo
      group was 22.3 +/- 1.9 min (mean +/- SEM) vs 11.3 +/- 1.4 min in the
      metoclopramide group (P less than 0.001). Fluoroscopy exposure time was 2.47 +/-
      0.25 in the placebo group vs 1.40 +/- 0.12 min in the metoclopramide group (P
      less than 0.001). Subjective clinical evaluation of the operator's assessment of
      the procedure was based on a 0-4 scale (much easier = 0, easier = 1, average = 2,
      harder = 3, and much harder = 4). Metoclopramide administration resulted in a
      significantly easier performance of the procedure (P less than 0.001) but did not
      influence patient tolerance. Three patients who received metoclopramide and one
      receiving placebo developed mild to moderate drowsiness of short duration. The
      results of this controlled trial indicate that metoclopramide significantly
      shortens the time required for jejunal biopsy and reduces fluoroscopy exposure.
      Its regulatory action on gastrointestinal motility contributes to the easier
      performance of a valuable diagnostic procedure.

PMID- 1015497
TI  - Fecal occult blood testing.

PMID- 1015498
TI  - Fulminant hepatic failure secondary to congestive heart failure.
AB  - An elderly female with an acute episode of congestive heart failure,
      unaccompanied by any periods of hypotension, developed fulminant hepatic failure
      with an accompanying coagulopathy. Attempts to establish an etiology for her
      acute hepatic insufficiency, other than cardiac failure, proved negative.
      Fulminant hepatic failure as a consequence of congestive heart failure, without
      prolonged periods of hypotension preceding alteration in hepatic function, has
      not heretofore been described. Liver function is adversely effected in congestive
      heart failure. Hepatic ammonia clearance is impaired in cardiac failure and may
      be diminished to the point of resulting in hepatic encephalopathy. Coagulopathy
      is a frequent concomitant of fulminant hepatic failure. Establishing a clear
      etiology for a coagulopathy in the face of concomitant liver disease is
      difficult, thus making any therapeutic intervention fraught with peril.

PMID- 1015499
TI  - Sororal occurrence of diffuse esophageal spasm.
AB  - In this report, we have described two sisters with classical symptoms,
      radiological appearances, and manometric features of diffuse esophageal spasm. To
      the best of our knowledge, familial occurrence of this disorder has not been
      documented previously.

PMID- 1015500
TI  - Colonic cancer--hypotheses of causation, dietary prophylaxis, and future
      research.
AB  - Colonic cancer is rare in primitive populations. In western populations it was
      uncommon in the past, but now accounts for about 3% of all deaths. The cause
      almost certainly lies with dietary changes. Probably, alterations in bowel milieu
      interieur, from interaction between metabolites and microbacteria, promote
      carcinogenesis. Changes in intakes of protein, fat, sugar, refined cereal
      products, and crude fiber have been advanced as predisposing or causative
      factors. Evidence suggests that (i) fall in fiber intake, but (ii) rise in fat
      intake, in their ability to increase fecal concentrations of bile acids and
      sterols (possible precursors of carcinogens) are most likely to be culpable. As
      preventive measures, a significant rise in fiber intake is practicable only from
      regular bran ingestion. A major reduction in fat intake is grossly unlikely. Even
      were rigorous dietary changes implemented, an early fall in colonic cancer
      incidence is highly improbable due to the long-term character of the disease.
      Future research must include characterization of the diet, metabolism, and
      disease pattern of segments of western populations who have low colonic cancer
      mortality rates; also, elucidation of the bearing of various intakes of different
      food components on the biochemistry and microbiology of the feces.

PMID- 1015501
TI  - Aspirin and prepyloric ulcer.

PMID- 1015502
TI  - Lysine-vasopressin: hemodynamic effects in the anesthetized dog.
AB  - Vasopressin (ADH) is known to reduce secretin-stimulated pancreatic exocrine
      secretion. The present study attempts to relate this inhibitory effect to the
      vasoconstrictive potency of ADH. Regional blood flow in most of the vascular
      areas. The greatest reduction in blood flow was seen in the gastrointestinal area
      especially in the left gastric artery, cranial and caudal pancreaticoduodenal
      arteries, as well as the cranial and caudal mesenteric arteries. Renal blood flow
      was not altered by those concentrations of ADH that reduced gastrointestinal
      blood flow. ADH reduced pancreaticoduodenal blood flow in concentrations
      comparable to those concentrations that reduced pancreatic secretory flow. The
      reduction of gastrointestinal blood flow was due to increased impedance and not
      to diminished cardiac inotropy.

PMID- 1015503
TI  - Effect of carbenoxolone on electrolyte output of salivary glands during
      nasogastric intubation.
AB  - The effect of carbenoxolone on the output of salivary electrolytes stimulated by
      a nasogastric tube was studied in healthy volunteers. Mean +/- SE values for
      volume and electrolyte concentrations in control studies were volume 121 +/- 19
      ml/hr, pH7.39, Na+19 +/-5, K+20 +/- U, Cl-20 +/- 3, HCO3-18 MEq/liter and
      osmolality 71 +/- 8 mOsm/kg. Mean +/- electrolyte outputs were quite large, Na+
      2.4, k+2.4, Cl-26, and bicarbonate 2.2 mEq/hr. Our control data indicate that in
      the course of gastric secretory testing the indwelling gastric tube stimulates
      salivary electrolyte output sufficient to interfere with accurate assessment of
      gastric ionic fluxes and gastric acid analysis. Therapeutic doses of
      carbenoxolone (100 mg three times daily) given orally for 3 weeks had no effect
      on salivary volume, electrolyte output, or concentration. We conclude that
      carbenoxolone has no minerallocorticoid effect on mixed salivary secretion.
      Attention to salivary secretion is recommended in all gastric secretory studies
      and is mandatory where low acid output is suspected.

PMID- 1015504
TI  - The effects of acute and chronic ethanol administration on canine bile secretion.
AB  - In 9 conscious dogs (4 of whom were alcohol-fed for 24 months with 50%
      intragastric ethanol), provided with gastric and duodenal fistulae (Thomas
      cannula), the effects were studied of an acute iv ethanol infusion (1.3 g/kg) on
      hepatic bile secretory plateau levels after emptying of the gallbladder was
      induced by a continuous perfusion of secretin (0.5 CU/kg/hr) plus CCK-PZ (8 Crick
      Harper-Raper U/kg/hr) and sodium taurocholate (0.62 mumol/kg/min). Acute iv
      ethanol infusion in nonalcoholic dogs reduced hepatic bile flow rate (29%), bile
      salt concentration (55%) and output (67%). In alcohol-fed dogs, acute iv ethanol
      reduced only the rate of flow (25%). Hepatic bile salt concentration and output
      plateau values were significantly higher in the alcohol-fed than in the
      nonalcoholic dogs. There were no significant differences between the two groups
      of dogs in the rate of evacuation, bile salt output, or lipid composition of gall
      bladder bile following a single iv injection of CCK-PZ.

PMID- 1015505
TI  - Gastric secretory function in patients with chronic renal failure undergoing
      maintenance hemodialysis.
AB  - Gastric secretion was evaluated in 9 male patients with chronic renal failure on
      maintenance hemodialysis. Five secreted low or normal quantities of acid and 4
      exhibited hypersecretion, 2 of whom had associated peptic ulcer disease. Serum
      gastrin responses to a protein meal were comparable to control subjects. Calcium
      infusion in two basal hypersecretors depressed acid secretion. The only
      statistically significant correlation observed was between basal acid output ans
      serum levels of parathormone. These studies suggest that while acid secretory
      abnormalities vary in patients with chronic renal failure on hemodialysis, there
      is no apparent sensitivity of the gastrin-secreting cells to protein or calcium
      ion which might account for acid hypersecretion. Secondary hyperparathyroidism
      may influence the occurrence of acid secretory abnormalities.

PMID- 1015506
TI  - Fibropolycystic disease of the hepatobiliary system and kidneys.
AB  - This complicated case of fibropolycystic disease of the hepatobiliary system and
      kidneys was ably and incisively analyzed by Professor Sheila Sherlock. Her
      clinical acumen was revealed by her ability to differentiate congenital hepatic
      fibrosis, Caroli's disease, and adult polycystic disease of the liver and kidney.
      Interesting histologic features of this case included hepatic fibrosis with
      intact limiting plates anc central veins and the presence of bile plugs in the
      ducts, but the absence of bile statsis in the parenchyma. A percutaneous
      transhepatic cholangiogram demonstrated the dilated intrahepatic and extrahepatic
      ducts. Washing out the "gunk" from the biliary tract by T-tube drainage has great
      limitations in this type of case. Therefore, Dr. Adson suggested irrigation of
      the biliary ductal system using tubed placed transhepatically, plus a wide
      choledojejunostomy. Dr. Sherlock questioned this surgical approach. The use of
      chenodeoxycholic acid for this "gunk" was suggested. In spite of the dilated
      ducts and pathologic changes in the liver, the patient was not jandiced and did
      not have stones in her biliary tract. The genetics of this patient's problems was
      discussed.

PMID- 1015507
TI  - Giardiasis: an overview for the clinician.
AB  - Since the clinician confronting a case of giardiasis may find the current
      literature confusing and weighted towards rare immunoglobulin deficiency
      syndromes, a classification is proposed to answer questions pertinent to
      understanding and managing this infection. Current thinking of giardiasis must
      involve the realization that (1) asymptomatic carriers exist; (2) that the
      majority of symptomatic patients have no structural disease explaining their
      symptoms; and (3) that those patients with anatomic lesions and giardiasis
      probably have an underlying predisposing condition. A short review of the
      association of giardiasis and immunodeficiency will then be presented, along with
      current concepts of diagnosis and therapy.

PMID- 1015508
TI  - A small strain gage for measuring intestinal motility in rats.

PMID- 1015509
TI  - Corn-on-the cop: treat or treat.

PMID- 1015510
TI  - The natural history of liver disease in former drug users.
AB  - Three hundred and twenty drug-free former narcotic addicts were studied with
      regard to persistence of abnormalities of liver function and morphology, and
      their relation to hepatitis B infection. Hepatitis B antibody was present in 52.4
      per cent, while HBs antigen was detected in only 6 per cent. Transaminase
      abnormalities, initially present in 39 per cent, were found in 22 per cent six
      months after cessation of drug abuse. Abnormalities tended to persist thereafter,
      although there was some continued return to normal levels. Liver biopsy findings
      of chronic persistent and aggressive hepatitis correlated with persistence of HBs
      antigenemia and transaminase elevation. Follow-up liver biopsies in seven
      subjects showed decreased inflammatory reaction in five. None showed progressive
      liver disease. We conclude that: (1) 15 to 20 per cent of former narcotics
      addicts have chronic persistent hepatitis or chronic aggressive hepatitis after
      cessation of drug absuse for six months or more; (2) serologic evidence of
      exposure to HBs antigen is frequent, and rapidly develops after the start of
      needle use; (3) although histologic ad chemical abnormalities usually persist,
      progression did not occur, and some individuals demonstrated spontaneous
      improvement.

PMID- 1015511
TI  - An increase in urinary catecholamines of renal origin in patients with
      "borderline" hypertension.
AB  - Plasma and urinary catecholamines (norepinephrine and epinephrine) and urinary
      dopamine excretion were studied in 45 essential hypertensive patients subdivided
      into borderline (labile) and stable hypertension. Borderline hypertensive
      patients had a higher mean fractional renal clearance of catecholamines (the
      clearance of catecholamines relative to creatinine clearance) than both control
      subjects and stable hypertensive patients. A significantly positive correlation
      between the renal clearance of catecholamines and urinary dopamine excretion was
      also found in those with borderline hypertension, but not in control subjects or
      those with stable hypertension. These data indicate that patients with borderline
      hypertension have a relatively exaggerated renal catecholamine release. They
      probably reflect an increased sympathetic discharge to the kidney in "borderline"
      hypertension, occuring to a lesser degree in stable hypertension and control
      subjects. Thus, urinary catecholamine measurements do not specifically reflect
      the level of circulating catecholamines, particularly in borderline hypertension.

PMID- 1015512
TI  - Meningioma associated with parathyroid adenoma.
AB  - A woman hospitalized because of attempted suicide with diazepam tablets was found
      to have hypercalcemia and other signs of hyperparathyroidism.
      Electroencephalogram indicated a brain lesion which was confirmed by a brain scan
      and angiogram. The hypercalcemia persisted after removal of the meningioma and
      serum levels of calcium returned to normal only after a parathyroid adenoma was
      removed during an additional intervention. This association of meningioma with
      hyperparathyroidism is unique in the literature. The difficulties of diagnosis
      resulting from the neuropsychiatric symptoms common to the two disorders are
      discussed.

PMID- 1015513
TI  - Vibrio fetus endocarditis in a patient with systemic lupus erythematosus.
AB  - Vibrio fetus endocarditis occurred in a patient with systemic lupus erythematosus
      receiving azathoprin and prednisone. Blood cultures required 14 days to become
      positive. The fastidious growth requirement of this organism is reviewed because
      lack of appreciation of these may result in failure to make the diagnosis. This
      is the first reported case of Vibrio fetus endocarditis occurring in the setting
      of a connective tissue disorder and immunosuppressive therapy.

PMID- 1015514
TI  - Purtscher's retinopathy in acute pancreatitis.
AB  - A patient who became blind following an episode of alcohol-induced pancreatitis
      is described. The clinical appearance of this patient's retinal changes
      corresponds most closely to post-traumatic (Purtscher's) retinopathy. The
      etiology of the retinopathy is best explained by retinal vascular occlusion due
      either to fat embolism or thrombosis.

PMID- 1015515
TI  - Polycythemia vera in an anephric man.
AB  - The effect of renal failure and bilateral nephrectomy on erythropoiesis and
      plasma erythropoietic activity was observed in a patient with polycythemia vera.
      For eight years the patient's hematocrit was maintained between 45 and 50 per
      cent by phlebotomy and in spite of the development of renal failure the
      hematocrit did not decline. Following rejection of a renal transplant, the
      hematocrit fell to 18 per cent but rose to 40 per cent with oral iron therapy.
      Following bilateral nephrectomy, the hematocrit fell to 29 per cent but
      subsequently increased to 37 per cent. After an episode of gastrointestinal
      bleeding the hematocrit was 21 per cent but subsequently rose to 32 per cent.
      Erythropoietin could not be detected in the plasma either before or after
      nephrectomy. In addition, erythropoietin failed to stimulate 59Fe incorporation
      into heme in vitro in the patient's marrow cells. The data incidate that, in
      polycythemia vera, erythropoiesis does not require erythropoietin.

PMID- 1015516
TI  - Cardiac tamponade in primary myxedema and review of the literature.
AB  - A case of cardiac tamponade secondary to primary myxedema is described. The
      nature of the patient's pericardial fluid and clinical course compared with other
      cases in the literature is reviewed. The patient had no recurrence of cardiac
      tamponade. Complete resolution of the pericardial effusion occurred 10 months
      followint initial pericardiocentesis and L-thyroxine therapy.

PMID- 1015517
TI  - Hageman factor deficiency in ataxia telangiectasia.
AB  - Ataxia-telangiectasia is clinically characterized by the presence of cerebellar
      ataxia, choreoathetosis, and oculocutaneous telangiectasia. Humorocellular immune
      deficiency may be associated with the disease. So far, no coagulation
      abnormalities have been reported in patients with ataxia-telangiectasia. Presence
      of Hageman factor deficiency in our patient could merely be a coincidental
      occurrence of two rare independent disease states. Since this coagulation
      abnormality in Hageman factor deficiency is rather subtle and not usually
      associated with clinically significant bleeding, this defect can be easily
      overlooked.

PMID- 1015518
TI  - "Pseudo-giant P-waves" and pericardial friction rub following chlorpromazine
      therapy.
AB  - A patient is presented who manifested two previously undescribed complications of
      chlorpromazine therapy: a transient pericardial friction rub and "pseudo-giant P
      waves". After slowing of the heart rate, the "giant P-waves" proved to be
      superimposed U and P-waves. His history demonstrates the protean and at times
      unusual complications of chlorpromazine therapy and illustrates the dramatic
      therapeutic effects diphenhydramine may have in reversing some of this toxicity.

PMID- 1015519
TI  - Strabismus measurements in the Siamese cat.
AB  - Anatomical and neurophysiological studies suggest a relationship between
      "abnormal" visual pathways and strabismus found in the Siamese cat. A
      telephotographic method for measuring eye positions in these cats reveals that
      newborn Siamese cats have a conspicuous exotropia appearance. Adult animals
      appear to have esotropia, orthophoria, or exotropia, which can be intermittent.

PMID- 1015520
TI  - Instrument myopia--microscopy.
AB  - Looking through optical instruments stimulates the eye to accommodate more than
      would be necessary for naked eye viewing; this increased near power is called
      instrument myopia. The amount (up to -5 diopters) varies with the observer and
      the conditions of viewing. Using microscopes produces -1.5 to -2 diopters of
      instrument myopia. More instrument myopia is found with low-power magnification,
      inexperienced users, and when focusing form minus blur to sharp image.
      Physiologically, the instrument myopia appears to be associated with an
      accommodative equilibrium position and, psychologically, with a sensing of
      proximity.

PMID- 1015521
TI  - Does stereopsis change with age?
AB  - Stereopsis thresholds were measured on 242 subjects with normal visual acuity and
      ranging in age from 8 to 46 years. The results showed no trend with age and no
      significant sex difference. The log-second threshold mean was 0.74+/-0.21 with a
      test-retest reliability coefficient of 0.70+/-0.05.

PMID- 1015522
TI  - A new electrode for electroretinography.
AB  - Clinical electroretinography is an uncomfortable, disquieting experience for a
      patient because of the contact lens electrodes used. Such electrodes are either
      expensive to buy or difficult to make. An aluminized Mylar electrode performs
      satisfactorily, elicits minimal patient apprehension or discomfort without
      topical anesthesia, is simple to make, and is disposable.

PMID- 1015523
TI  - Biofeedback reinforcement in the training of limitation of gaze: a case report.
AB  - A 22-year-old patient having a history of congenital strabismus with surgery at
      age 6 and again at age 14 suffered from a limitation of dextroversion following 2
      surgical procedures with diplopia initially experienced beyond 18 degrees. Ten
      sessions of treatment by traditional visual training methods and biofeedback
      reinforcement were compared in extending the deficient range of dextroversion.
      Biofeedback was found to be significantly better than conventional approaches in
      this treatment.

PMID- 1015524
TI  - Epidemiological considerations in predicting regional vision health care needs.
AB  - The use of crude practitioner to population ratios when age-specific ratios are
      more appropriate can lead to significant errors in estimates of the need for
      health care manpower. A comparison of these 2 methods is made using age-specific
      data for Florida as an example. A brief survey of other epidemiological factors
      affecting clinical manpower projections is given.

PMID- 1015525
TI  - Effects of non-contact tonometry on refraction.
AB  - The spherical component of refractive error was measured subjectively before and
      after noncontact tonometry in 19 eyes and also on the fellow (control) eyes
      without tonometry. No significant change in this measure of refractive error was
      found after tonometry. The tested group could not be distinguished from the
      control group.

PMID- 1015526
TI  - Effective degree of mydriasis with phenylephrine and tropicamide.
AB  - The mydriatic effects of several concentrations of phenylephrine and of
      tropicamide were studied in 84 young adults for 90 min following topical
      instillation. Pupillary diameter was estimated (a) under ambient photopic
      illumination and (b) when illumination was increased to that associated with
      direct ophthalmoscopy. Evaluation was made of the "degree of mydriasis," i.e.,
      the difference in pupillary diameter between the eye receiving the mydriatic
      agent and the contralateral control eye when the pupillary light reflex was
      stimulated. In subjects with light or hazel irides, phenylephrine caused maximal
      dilatation in 60 to 75 min, mean values being 5.6 mm with 1 drop of 2%, 6.0 mm
      with 2 drops of 2.5%, and 7.1 mm with 1 drop of 10%. Maxiumum degrees of
      mydriasis were 3.0 mm with 2 drops of 2.5% and 3.1 mm with 1 drop of 10%. With
      0.5% tropicamide, maximum diameter was 8.0 mm in 30 min in subjects with light,
      hazel, or brown irides, and the maximum degree of mydriasis was 5.0 mm. It is
      concluded that when a mydriatic agent is used to facilitate intraocular
      visualization, neither specification in terms of (a) maximum diameter under
      ambient illumination nor (b) degree of mydriasis provides optimal
      characterization. It is suggested that the "clinically effective diameter," i.e.,
      pupillary diameter under illumination corresponding to that to be used during
      examination, would be the most useful specification.

PMID- 1015527
TI  - Dynamic and static violations of Hering's law of equal innervation.
AB  - Hering's Law of Equal Innervation treats the double eye as a single organ. Normal
      humans often execute saccadic eye movements that are dynamic violations of
      Hering's Law. These infractions are produced by differences in the neural
      controller signals sent to each eye and are exemplified by monocular movements,
      such as dynamic overshoot, glissades, and double saccades; these dynamic
      violations occur more frequently in fatigued subjects. In contrast to dynamic
      violations, static violations of Hering's Law are usually indicative of
      pathological conditions.

PMID- 1015528
TI  - Survey of student research in behavioral and developmental optometry.
AB  - Behavioral and developmental optometry are in need of research. Studies conducted
      by optometric students can provide a major contribution. The present paper
      reviews selected student research studies conducted at the Illinois College of
      Optometry. The topics include: trends in developmental vision, phenomena in
      binocular vision, and techniques in diagnosis and treatment.

PMID- 1015529
TI  - The relationship between eye dominance and monocular acuity: an additional
      consideration.
AB  - Multivariate techniques  were used to explore the relationship between ocular
      dominance and asymmetries in visual acuity or acuity dominance. The convergence
      distance under which the acuity testing takes place was found to affect the
      relationship between these two variables.

PMID- 1015530
TI  - Acuity measurements-- do they indicate how well a partially sighted person
      functions of could function?

PMID- 1015531
TI  - Reconstruction after pharyngolaryngectomy-esophagectomy.
AB  - Seventeen patients with carcinoma of the hypopharynx and/or cervical esophagus
      who require total pharyngolaryngectomy-esophagectomy are presented; Twenty-one
      different reconstructive methods were applied in the seventeen patients. An
      overall two year survival rate of 35 per cent was attained with effective
      palliation in 65 per cent of the patients. The Wookey and free jejunal
      transplantation procedures were unsuccessful as primary means of
      pharyngoesophageal reconstruction, although the Wookey principle was occasionally
      useful in salvaging failures of other procedures. The reversed deltopectoral flap
      was successfully employed in a small number of patients with only minimal
      extension below the cricopharyngeus but was found to be unfeasible in several
      other instances because of the extent of esophageal resection required.
      Transposition of the entire stomach was successfully employed in a number of
      suitable patients and is an excellent method of esophageal replacement in
      relatively healthy patients. The reversed gastric tube esophagoplasty was useful
      in more debilitated patients, with resection and reconstruction performed in
      separate stages.

PMID- 1015532
TI  - Squamous cell carcinoma of the oropharynx: why we fail.
AB  - The squamous cancers of the oropharynx in 384 patients were staged according to a
      T and N system. Three hundred seventy-one of them were treated for cure at a time
      when modern surgical and radiotherapeutic technics were available. The patient
      records were analyzed in regard to five year survival, factors influencing
      treatment failure, and the effect of new primary cancers. Failure to eradicate
      the cancer at the primary site remains the largest reason for the patients'
      demise, but as aggressive local and regional treatment becomes more successful,
      greater numbers of patients survive only to become victims of distant metastases
      and second primary cancers.

PMID- 1015533
TI  - Carcinoma of the hypopharynx.
AB  - The data in this study suggest that radical surgical treatment offers the best
      chance for control of disease in patients with cancer of the hypopharynx. The
      cervical lymph nodes are at a very high risk for early involvement by metastatic
      disease. Elective treatment of cervical lymph nodes must be considered in initial
      treatment planning to obtain better control of regional disease.

PMID- 1015534
TI  - Surgical exploration in asymptomatic hypercalcemia.
AB  - The use of the serum auto-analyzer (SMA-12) has resulted in a marked increase in
      the diagnosis of hyperparathyroidism. Seventy-five patients with asymptomatic
      hypercalcemia were explored: sixty-eight with solitary adenomas, six with
      multiple adenomas, and one with diffuse hyperplasia. Postoperatively, all
      patients reverted to normocalcemia. Surgical exploration of asymptomatic
      hypercalcemia is advocated to reduce surgical morbidity and mortality and to
      prevent the development of renal and osseous complications of
      hyperparathyroidism.

PMID- 1015535
TI  - Management of recurrent salivary gland tumors.
AB  - The management of 129 patients with recurrent tumors of the salivary glands is
      analyzed, Principles of approaching recurrent tumors and guidelines for their
      management are outlined in detail. Age distribution, symptoms, time to
      recurrence, cases that showed possible malignant degeneration, and complications
      are reviewed. The surgical procedures, recurrence rate, and survival rates are
      recorded.

PMID- 1015536
TI  - The malignant "cold" nodule of the thyroid.
AB  - From 1958 to 1976, 910 patients with cold nodules of the thyroid underwent
      thyroid surgery (714 females, 196 males). Thyroid carcinoma was present in 202
      patients (22.2 per cent) (149 females, 20.9 per cent; 53 males, 27 per cent).
      Rate of malignancy in an age group was greatest in patients older than seventy
      years (19 of 47 patients, 40.4 per cent) followed by patients twenty-one to
      thirty years of age (37 of 125 patients, 29.6 per cent); 90 per cent of all
      patients were from twenty-one to seventy years of age. Blacks had a lower rate of
      thyroid carcinoma than Caucasians. Data from the Cancer Surveillance Group also
      showed age-adjusted incidence rates in blacks in Los Angeles County to be lower
      than that of Caucasians.

PMID- 1015537
TI  - The undelayed Mutter flap in head and neck reconstruction.
AB  - Twenty-one mastoid-occiput-based shoulder flaps have been used to reconstruct
      patients with head and neck cancer. When the tip of the flap does not extend
      beyond the midclavicle, this flap can safely be elevated and transferred into its
      final position without delay procedures. Not requiring secondary sectioning and
      implantation, the Mutter flap can successfully be used to reconstruct multiple
      defects within its arch. Its utility thus rivals the more commonly used medially
      based deltopectoral flap and forehead flap.

PMID- 1015538
TI  - Results of BCG adjuvant immunotherapy for melanoma of the head and neck.
AB  - The present study was performed to determine if postoperative systemic BCG
      adjuvant immunotherapy would improve survival in patients with pathologic stage
      II melanoma of the head and neck. Seventeen of twenty-five (68 per cent) patients
      treated with BCG are free of disease, whereas only seven of seventeen (40 per
      cent) patients treated by radical neck dissection alone are free of disease.
      Clark's technic for determining the level of invasion of the primary lesion was
      used to predict the presence of metastatic tumor in regional lymph nodes. Results
      indicate that patients with pathologically confirmed lymph node metastases from
      melanoma of the head and neck benefit from postoperative BCG adjuvant
      immunotherapy.

PMID- 1015539
TI  - Analysis of survival and disease control in stage I melanoma of the head and
      neck.
AB  - From 1958 through 1969, 357 patients were treated for melanoma of the head and
      neck. Of these, 166 had invasive, clinical stage I disease. All patients had wide
      local excision of the primary. Elective regional node dissection was performed in
      sixty-nine patients and in the remaining ninety-seven observation only was
      elected. Retrospective analysis of these 166 patients considered (1) survival and
      disease control, (2) sites and timing of failures, and (3) the effect of sex,
      site, type of biopsy, skin grafting, and regional node dissection on disease
      control and survival. More than 80 per cent of the local recurrences developed
      within the first twenty-four months. Similarly, in the patients not undergoing
      initial neck dissection, 80 per cent of those who subsequently had clinically
      positive regional nodes did so within twenty-four months. In the sixty-nine
      patients undergoing elective regional node dissection, the survival rate was 33.5
      per cent at five and ten years in those with histologically positive nodes. Those
      patients with elective neck dissections having histologically negative nodes had
      a survival rate of 75.8 and 67.1 per cent at five and ten years, respectively.

PMID- 1015540
TI  - Advanced and recurrent squamous carcinoma of the lower lip.
AB  - The results of aggressive surgical treatment of primary lip cancer and advanced
      and recurrent carcinoma of the lip are illustrated and discussed. Early detection
      of involved lymph nodes before capsular penetration occurs and careful and
      complete dissection of the submental and submandibular regions are advocated as
      possible ways to prevent persistent upper neck disease, the main killer of these
      patients.

PMID- 1015541
TI  - Carcinoma of the palatine arch.
AB  - 1. Carcinoma of the palatine arch is part of a regional diathesis of carcinoma of
      the mucosa of the upper aerodigestive tract and this concept has a definite
      influence on the choice of treatment. 2. Surgery has an important role in the
      management of both the primary tumors and the regional metastatic nodes. 3.
      Radiation therapy is indispensible in the management of carcinoma of the
      tonsillar crypts, stage IV tumors of the palatine arch, and primary tumors of the
      palatine arch with certain specific extensions. 4. Comprehensive management of
      carcinoma of the palatine arch requires careful evaluation of each patient and
      his disease, vigorous application of the chosen method of treatment by either the
      surgeon or the radiotherapist, and continuous follow-up study and supportive
      treatment for the rest of the patient's life.

PMID- 1015542
TI  - Carcinoma of the oral cavity. factors affecting treatment failure at the primary
      site and neck.
AB  - A retrospective review of the clinical records of patients with carcinoma of the
      oral cavity was undertaken, and several parameters were studied in terms of
      comparing two groups of patients: those who were controlled at the primary site
      and neck and others who failed locally or regionally following initial treatment.
      A comparative statistical analysis of the factors studied revealed that female
      patients who had a higher T status, a higher N status, and thus a higher stage of
      disease did poorly in terms of local and regional control of disease. Those
      patients whose primary tumors manifested deep invasion and those who had positive
      margins after surgical resection at the primary site had also a significantly
      high incidence of local/regional failure. Presence of extracapsular extension of
      disease in cervical lymph nodes and involvement of soft tissues in the neck as
      well as involvement of multiple lymph nodes at multiple levels also put the
      patients in a high risk category. We urge that these factors be considered as
      prognostic criteria and be used to select patients for treatment by additional
      modalities on an elective basis in hope of achieving better local and regional
      control of disease and perhaps better cure rates.

PMID- 1015543
TI  - Treatment of carcinoma of the oral tongue by radium needle implantation.
AB  - Forty-nine patients had a radium implant for carcinoma of the oral tongue. In
      thirty-four of the forty-nine (70 per cent), local three year control of the
      cancer was achieved. Three patients in whom the radiation failed were rescued by
      subsequent surgery. The five year absolute survival in this series was 63.8 per
      cent. In conclusion, we believe that improved survival rates without functional
      and cosmetic defect can be obtained by closer cooperation between surgeons and
      radiotherapists.

PMID- 1015544
TI  - Clinical staging of cancer of the head and neck: a new "new" system.
AB  - A revised clinical staging system for cancers arising in head and neck sites has
      been prepared. It utilizes a uniform N classification for cervical node
      metastases. The T classifications describing the extent of the primary tumor are
      generally similar but differ in specific details for each site. Although the
      present system makes use of past field trials and more recent clinical studies,
      it cannot be considered final. Clinicians managing cancer in head and neck sites
      are encouraged to test the system with their own patient data to elicit further
      areas for improvement.

PMID- 1015545
TI  - Applications of the Karapandzic principle of lip reconstruction after excision of
      lip cancer.
AB  - The number and variety of technics available for lip reconstruction has suggested
      to some authors that no method is ideal. In fact, excellent results can be
      obtained under proper circumstances by any one of several procedures. The
      principle of innervated myocutaneous flaps adds yet another tool to the surgeon's
      armamentarium, but it does not relieve him of the responsibility to select the
      most appropriate procedure in each case. As Karapandzic has stated (or
      understated), "This obviously is not a technique suitable for all lip defects,
      but in selected cases it gives a very satisfactory result."

PMID- 1015546
TI  - Immediate repair of the Commando defect by cervical and pectoral flaps.
AB  - A ten year experience with immediate cervical flap repair of the Commando defect
      is reported in a selected series of more than seventy patients with clinically
      negative neck-nodes. Preoperative radiotherapy of 2"000 and 3,000 r to the neck
      and primary tumor has not interfered with wound healing. The cosmetic and
      functional result is highly commendable.

PMID- 1015547
TI  - Combined radiation-methotrexate therapy in preoperative management of carcinoma
      of the head and neck.
AB  - Fifty patients with primary carcinoma of the head and neck were treated
      preoperatively with 2,000 r and 500 mg/m2 of methotrexate. This combination
      reduces the tumor size in more than 90 per cent of patients, converts many of the
      tumors to a more manageable state, and appears to indicate that improved survival
      will occur.

PMID- 1015548
TI  - [Decrease in erythrocyte 2,3 diphosphoglycerate levels in relation to elevated
      lactate concentration in the medium and restoration of these levels under the
      influence of dihydroxyacetone].

PMID- 1015549
TI  - Changes in some metabolic effects of isoprenaline and glucagon in normotensive
      and spontaneously hypertensive rats.

PMID- 1015550
TI  - [An attempt to interpret certain metabolic effects of ketamine].

PMID- 1015551
TI  - [Changes in nitrogen balance during the period following abdominal surgery and
      use of an injectable anti-aldosterone].

PMID- 1015552
TI  - General and cerebral hypothermia in the treatment of intractable epilepsy. A
      report of 3 cases.

PMID- 1015553
TI  - [State of the cardiac activity of fetus and newborn following electroanalgesia
      during labor].

PMID- 1015555
TI  - [Use of cranio-cerebral hypothermia for treatment of neonatal asphyxia].

PMID- 1015554
TI  - [Value of electropolygraphic studies of sleep for assessment of the condition of
      children born in asphyxia].

PMID- 1015556
TI  - [Osmoregulatory function of the kidneys following parenteral fluid administration
      to premature infants].

PMID- 1015557
TI  - [Ways of reducing perinatal mortality].

PMID- 1015558
TI  - [Functional morphologic characteristics of the placenta in late toxemias of
      pregnancy].

PMID- 1015559
TI  - [Medical rehabilitation of patients with and patients recovered from toxemia of
      pregnancy].

PMID- 1015561
TI  - [Restoration of the menstrual cycle following normal labor].

PMID- 1015560
TI  - [Increased risk of development of late toxemia of pregnancy and its subclinical
      form].

PMID- 1015562
TI  - [Methods for the prevention of puerperal suppurative-septic diseases].

PMID- 1015563
TI  - [Prenatal diagnosis of fetal developmental defects from anamnestic findings and
      the course of pregnancy].

PMID- 1015564
TI  - [Basic principles of antibiotic therapy in infectious puerperal diseases].

PMID- 1015565
TI  - [Effect of complex therapy on the immunologic reactivity of patients with
      inflammation of the internal sex organs].

PMID- 1015566
TI  - [Our experience with the treatment of severe coagulopathic hemorrhages associated
      with uterine atony (hypotonia)].

PMID- 1015567
TI  - [Organizational aspects of preventive screening of women with mass cytological
      studies].

PMID- 1015568
TI  - [Relationship between the spermogram and the means of obtaining sperm].

PMID- 1015569
TI  - [Duration of continuous use of intrauterine contraceptives].

PMID- 1015570
TI  - [Large dermoid cyst of the mediastinum in a pregnant woman].

PMID- 1015571
TI  - [Mixed gonadal dysgenesis with a neoplasm on one side].

PMID- 1015572
TI  - [Concentration of chorionic gonadotropin in the blood of mother and fetus during
      labor].

PMID- 1015573
TI  - [Acid-base equilibrium, gas composition and electrocardiographic observation of
      cases of fetal distress].

PMID- 1015574
TI  - [Epidemiology and prevention of hospital infections in an obstetrics-gynecology
      department].

PMID- 1015575
TI  - [Cervical incompetence. Our experience with McDonald's operation in 220
      pregnancies].

PMID- 1015576
TI  - [Hysterography following repeated cesarean section].

PMID- 1015577
TI  - [Direct determination of the size of the conjugata vera on a profile x-ray of the
      bones of the birth canal].

PMID- 1015578
TI  - [Ionizing radiations and their repercussions on the basic functions of the female
      genital system (external radiation)].

PMID- 1015579
TI  - [Late results of the treatment of endometrial cancer according to materials from
      the district oncologic dispensary of V. Turnovo].

PMID- 1015580
TI  - [Our experience with the use of phototherapy in newborn infants].

PMID- 1015581
TI  - [We lag in the special and intensive care of newborns].

PMID- 1015582
TI  - [Rare case of abdominal pregnancy].

PMID- 1015584
TI  - The current management of malignancy--V tumors of the gastrointestinal tract.

PMID- 1015583
TI  - [Rare cause of antenatal fetal death].

PMID- 1015585
TI  - Gonorrhea control in Alaska.

PMID- 1015586
TI  - President's page.

PMID- 1015587
TI  - [Use of diflucortolone in various dermatological processes].

PMID- 1015589
TI  - [Toxic epidermal necrolysis (Lyell's syndrome)].

PMID- 1015588
TI  - [Current status of iodine therapy in the treatment of asthma in children].

PMID- 1015590
TI  - [The salvage horizontal laryngectomy (personal experience in 31 cases)].

PMID- 1015591
TI  - [Our experience with the exploration and study of cervical nystagmus].

PMID- 1015592
TI  - [Surgical rehabilitation of nose injuries (treatment of endonasal structures)].

PMID- 1015594
TI  - [Evaluation of levels of audition in children].

PMID- 1015593
TI  - [Neural tumors of the larynx. Lateral pharyngectomy in the approach to the
      laryngeal vestibule].

PMID- 1015595
TI  - [Unusual otorhinolaryngology].

PMID- 1015596
TI  - [Anatoma surgical views on the transtemporal approach to the internal auditory
      canal].

PMID- 1015597
TI  - [Sensorineural deafness and perilabyrinthine pneumatization].

PMID- 1015598
TI  - [5 cases of Rendu-Weber Osler disease].

PMID- 1015599
TI  - Training in anesthesiology.

PMID- 1015600
TI  - Electrocardiographic studies during hypotensive anaesthesia using sodium
      nitroprusside.
AB  - Multiple lead electrocardiographic recordings from 20 patients were studied
      before, during and after a period of induced hypotension with sodium
      nitroprusside. Although small changes in ST segment and T wave were observed in 9
      patients, none of these persisted into the postoperative period. Other
      significant changes were confined to a temporary disturbances of cardiac rhythm
      in 2 patients, both of whom spontaneously reverted to sinus rhythm during the
      anaesthetic. Our findings indicate that there are no permanent ischaemic
      myocardial changes associated with induced hypotension using sodium
      nitroprusside.

PMID- 1015601
TI  - Cardio-respiratory changes during pneumoencephalography.
AB  - Carbon-respiratory changes associated with changes in posture and injection of
      intrathecal oxygen were studied in fifeen patients undergoing
      pneumoencephalography in a Phillips isocentric chair, while breathing
      spontaneously and anaesthetised with halothane in oxygen. Haemodynamic changes
      associated with changes in posture were of a minor nature. A rise in PaCO2
      occurred in the prone position in two obese patients. There were significant
      rises in blood pressure following injection of more than 5 ml of oxygen as a
      bolus into the subarachnoid space.

PMID- 1015602
TI  - The administration of metoclopramide with atropine. A drug interaction effect on
      the gastro-oesophageal sphincter in man.
AB  - The effects of intravenous atropine 0-6 mg alone, metoclopramide (Maxolon) 10mg
      alone and atropine 0-6 mg and metoclopramide 10 mg in combination, on the lower
      oesophageal sphincter (LOS) were studied in three groups of normal human
      volunteers. Atropine decreased the LOS pressure by an average of 8 cm H2O (P less
      than 0-001), whereas metoclopramide increased the LOS pressure by a mean of 29
      cmH2O compared to basal values (P less than 0-001). In contrast, no change in
      sphincter tone was noted following injection of atropine-metaclopramide mixture.
      These findings are relevant to the pre-operative preparation of patients
      presenting for emergency anaesthesia, since gasgro-oesophageal reflux and
      pulmonary aspiration of acid gastric content continues to be a significant cause
      of morbidity and mortality.

PMID- 1015603
TI  - The reliability of a linear analogue for evaluating pain.
AB  - A linear analogue for rating pain with 10, 15 and 20 cm lines is significantly
      less variable than a 5 cm line (mean error of 15 cm line is 0-19%, 95% confidence
      limits for the group +/- 2% and an inood correlation between repeated ratins of a
      recalled pain distant in time. The variance of the rating is significantly less
      than the repeated rating of a random mark. The linear analogue rating of a
      constant pain stimulus is reproducible and changes in rating are likely to be
      real changes of opinion. Pethidine 150 mg intramuscularly had no significant
      effect, tested 30 minutes after the administration, on the accuracy or
      reproducibility of the analogue rating. A linear analogue seems a suitable method
      of recording the patient's opion of a severe pain such as that of labour.

PMID- 1015604
TI  - Anaesthetic records in Great Britain and Ireland.
AB  - A survey of anaesthetists and their use of anaesthetic records was carried out in
      Great Britain and Ireland. An analysis of 206 different record sheets from 175
      hospitals or groups showed that, although many features were similar, important
      aspects were omitted in some, while others had too many options which were not
      necessarily relevant to the administration of an anaesthetic. No attempt has been
      made to offer an ideal design for an anaesthetic record, but the information may
      assist those anaesthetists wishing to change the current practice in their
      hospital or group.

PMID- 1015605
TI  - Multiple sclerosis and surgery.
AB  - Five patients with multiple sclerosis showed deterioration following operation
      and anaesthesia. In every case the change was associated with pyrexis due to
      infection. No correlation was found between aggravation and any anaesthetic agent
      used.

PMID- 1015606
TI  - Hyperbaric oxygen in acute ischaemia due to allergic vasculitis.
AB  - A case of a child with allergic vasculitis to penicillin is presented. The
      patient received successful treatment with hyperbaric oxygen (HBO) therapy. The
      pathophysiological mechanism of acute peripheral anoxia and the infleunce of HBO
      treatment on it is described.

PMID- 1015607
TI  - Removal of catecholamine-secreting chemodectoma. The use of neuroleptanaesthesia,
      adrenergic blockade and sodium nitroprusside.
AB  - A case of catecholamine-secreting chemodectoma of the neck in a 47-year-old male
      who also had temporal lobe epilepsy is described. Details of presentation,
      diagnosis and successful treatment are given. He was fully alpha blocked with
      phenoxybenzamine and given neuroleptic drugs but his blood  pressure rose to
      dangerous levels when the tumour was handled and did not respond to intravenous
      phentolamine. Sodium nitroprusside was successfully used to achieve blood
      pressure control.

PMID- 1015608
TI  - Air embolism during anaesthesia for arthography in a child.
AB  - An infant aged 5 months, weighing 6 kg and suffering from congenital dislocation
      of the hip joint, was subjected to air arthrography of the right hip joint under
      general anaesthesia. Air embolism occurred following injection of air into the
      joint. The clinical management is described. Resuscitation was successfully
      accomplished and the patient was discharged from hospital without untoward
      sequelae.

PMID- 1015609
TI  - The Lack anaesthetic system. An assessment during spontaneous ventilation.
AB  - The Lack anaesthetic system is a coaxial modification of the Magill circuit. The
      resistance of the system was found to be unacceptably high. When air was
      administered through the system to spontaneously breathing trained volunteers,
      marked evidence of rebreathing was present when fresh gas flow equalled minute
      volume. It is suggested that a fresh gas glow equal to one and a half-times
      minute volume would be required to prevent rebreathing of alveolar gas.

PMID- 1015610
TI  - A safety block for scavenging systems.
AB  - A safety block is described which protects the patient from expiratory
      obstruction when using scavenging systems, and provides the anaesthetist with a
      visual and auditory check on the functioning of the system.

PMID- 1015611
TI  - A light for anaesthetists.
AB  - A new type of lighting device is incorporated into the ether screen cross-bar,
      enabling better illumination of the patient's face. A 12-V, DC power supply is
      used. The temperature, with vacuum-assisted cooling, should not cause burns to an
      unconscious patient. Assessment of patient colour was evaluated and found to be
      reliable. The lamp must not be used with flammable anaesthetic agents.

PMID- 1015612
TI  - The immediate use of antimicrobial agents.
AB  - The use of antimicrobial agents in the surgical period is discussed with
      reference to the role of the anaesthetist in prophylaxis against the spread of
      infection in the patient, the treatment of established infection, the protection
      of the anaesthetist against infection from the patient and of the patient against
      the side-effects of the antimicrobial agents themselves.

PMID- 1015613
TI  - The effects of deliberate hypotension and foot down tilt on the incidence of deep
      vein thrombosis during plastic surgical operations: a pilot survey.
AB  - The incidence of postoperative deep  vein thrombosis (DVT) has been investigated
      in a group of 88 patients undergoing plastic surgical operations on the head and
      neck, and upper limb. Fifty-two cases were operated upon in the foot-down tilt
      position and 36 were horizontal. With the effects of blood pressure ignored as a
      possible contributory factor, the incidence of thrombosis in the latter group was
      8-3% and was slightly higher in the tilted group (11-5%). Of those who were
      hypotensive, 3 developed DVT out of 41 (7-3%) who were tilted; whilst in the 11
      who were normotensive and tilted 3 developed DVT, an incidence of 27-3%. Of those
      who were normotensive and operated flat the incidence of deep vein thrombosis was
      8-0%, while in those subjected to a foot-down tilt it was 27-3%. The hypothesis
      has been advanced that frequent inflation and deflation of the cuff used for
      monitoring blood pressure in the hypotensive patients may release fibrinolytic
      activity and explain these differences. Age, sex and operative duration were not
      found to have an effect. It is concluded that the incidence of postoperative deep
      vein thrombosis in patients undergoing plastic surgical operations is lower than
      that found in general surgery, and is not worsened by deliberate hypotension.

PMID- 1015614
TI  - The epidural sieve and MBC (minimal blocking concentration): an hypothesis.
AB  - Certain painful stimuli-of which those associated with placental abruptio and
      impending rupture of a uterine scar are examples-can penetrate an apparently well
      established lumbar epidural block. As a possible explantation of this anomaly, it
      is suggested that, when used in the concentrations currently employed, the local
      anaesthetic reaches nerve axons only slightly above the minimal blocking
      concentration (MBC) of the drug, and that a more powerful stimulus can provoke an
      impulse which may be conducted through the "blocked" segment of axon. The
      beneficial aspects of the "epidural sieve" should be welcomed and no attempt made
      to eliminate the phenomenon.

PMID- 1015615
TI  - A method of anaesthesia for fractional coagulation of the Gasserian ganglion.
      Intermittent anaesthesia with propanidid.
AB  - A method of anaesthesia is described for fractional coagulation of the Gasserian
      ganglion. The surgical procedure demands short periods of anaesthesia alternating
      with periods of full consciousness, during which sensory testing is carried out.
      In spite of the rare possibility of a hypotensive reaction, propanidid is
      considered to be the drug of choice for this technique. 31 patients wih typical
      trigeminal neuralgia have been treated with immediate relief of symptoms, whilst
      3 (10%) have been successfully re-treated after recurrence of pain paroxysms. Two
      patients developed lung emboli, from which they recovered, in the post-operative
      period, and a third patient had a non-fatal myocardial infarct a week after
      treatment. Alternative approaches to the problem of intermittent anaesthesia,
      with and without intubation, are discussed.

PMID- 1015616
TI  - Assessment of methods of anaesthesia used for total alloplasty of hip joint with
      application of bone cement.
AB  - The authors analyse 151 cases of anaesthesia for total hip joint alloplasty.
      Fifty-three patients had general anaesthesia and in 98 cases epidural analgesia
      was performed. Although the statistical analysis of correlations between the fall
      of the arterial blood pressure and the age of patients failed to demonstrate
      significant differences between both types of anaesthesia the authors regard
      local analgesia as superior.

PMID- 1015617
TI  - The effect of bone cement used for endoprosthesis stabilization on the activity
      of lysosomal enzymes in peripheral blood granulocytes.
AB  - The effect of bone cement used for stabilization of hip joint endoprosthesis on
      the activity of lysosomal enzymes in peripheral blood granulocytes was studied.
      The operations were carried out under balanced, non-toxic, endotracheal
      anaesthesia using muscle relaxants. The blood for tests was obtained from an
      antecubital vein before and during anaesthesia, before application of bone
      cement, and 10 min., 1 hour and 24, 48 and 72 hours after endoprosthesis
      implantation using bone cement. The activity of acid phosphatase, acid protease
      and neutral protease was determined by calculating it in relation to protein
      level in the studied fractions. During anaesthesia as well as during the
      operation when bone cement was applied no statistically significant differences
      were found in the activity of lysosomal enzymes. On the other hand, after the
      operation statistically significant changes were found in the activity of
      lysosomal marker enzymes. Lability of lysosomal membranes appeared with
      permeation of hydrolases into supernatant. These results confirmed the importance
      of lysosomal proteins in the processes of wound healing and general postoperative
      course.

PMID- 1015618
TI  - Iontophoretic blockade in treatment of carotid sinus syndrome.
AB  - The author describes the results of treatment by his own modification of carotid
      sinus blockade with lidocaine electrophoresis in 17 patients. The results
      confirmed the effectiveness of the method and demonstrates its simplicity and
      safety.

PMID- 1015619
TI  - Improved method for the determination of acrylamide monomer in water by means of
      gas - liquid chromatography with an electron-capture detector.

PMID- 1015620
TI  - Elimination of ionic interferences in the determination of sulphates in water
      using the lead-sensitive ion-selective electrode.

PMID- 1015621
TI  - Semi-automated determination of lead by hydride generation and atomic-absorption
      spectrophotometry.

PMID- 1015622
TI  - Determination of residues of oxamyl in crops and soils by gas - liquid
      chromatography.

PMID- 1015623
TI  - An ultraviolet spectral and polarographic study of nitrofurantoin, a urinary
      tract antibiotic.

PMID- 1015624
TI  - Rapid assay of proteinase activity in papain by measuring the increase in
      opalescence of a casein solution during hydrolysis.

PMID- 1015625
TI  - The development of the intramural nerve plexus of the gastro-intestinal tract.
AB  - The chicken intestinal tract from the 6th day of breeding until the 20th day
      after hatching was examined histochemically for acetylcholinesterase activity.
      The enzyme was detected first in the perikarya and subsequently also in the
      ganglion-cells processes. The appearance of the acetylcholinesterase reaction
      deposit was observed first in the stomach and duodenum and later in the rectum.
      The histogenetic development of the intramural plexus in the small gut proceeds
      caudad, but in the colon in the opposite way, i.e., craniad. In the duodenum and
      colon the nervous development is complete in chicken embryos of 11-12 days and in
      the rest of the small intestine in embryos of 13-14 days of breeding. In the
      human embryo of 60 mm CRL the development of the intramural plexus is already
      completed.

PMID- 1015626
TI  - In vitro elastic fiber formation by aggregated arotic cells of newborn rabbits.
AB  - Cells isolated enzymatically from the aortas of newborn rabbits were aggregated
      and grown in organ culture. Bundles of microfibrils, some of them with an
      amouphous core (elastin), were evident in 3-day-old aggregates. Furthermore,
      droplets of elastin surrounded by darker dots and short filaments, corresponding
      to the elastic units were observed. In 6-day-old aggregates the number of elastic
      fibers composed of bundles of microfibrils with deposited elastin increased.
      Elastic elements which probably resulted from a coalescence of elastic units were
      also present. These two ways of elastic fiber formation in aggregates are
      compared with those described in papers on aortic development.

PMID- 1015627
TI  - The onset of ossification in the human calcaneus.
AB  - A (silver) radiographic and microscopic study of the onset of ossification in the
      calcaneus of 177 human fetuses between 49 and 150 mm C.-R. length has revealed
      the presence of two independent and developmentally different ossific sites. A
      lateral locus, intramembranous (parachondral) in origin and precocious in
      appearance, was observed in slightly over 16% of the fetuses examined between 93
      mm (the first appearance of this bone) and 150 mm C.-R. It occupied the vascular
      connective tissue within the anterior portion of a distinct groove on the
      inferolateral wall of the cartilaginous calcaneus between the retrotrochlear
      eminence anterosuperiorly, and the lateral process of the tuber
      posteroinferiorly. A centrally situated, primary ossific centre, endochondral in
      origin, was detected in only 11% of the fetuses between 118 mm (the initial
      appearance of this centre) and 150 mm C.-R. It was situated in the centre of the
      anterior third of the cartilaginous calcaneus in relation to the sustenaculum
      tali medially and to a distinct cartilaginous prominence on its lateral surface.
      Only four fetuses possessed both ossific sites (lateral and central): at 122,
      143, 145, and 150 mm C.-R., and in only one of these was continuity established
      between them. One fetus (122 mm) possessed two independent endochondral centres
      (superior and inferior).

PMID- 1015628
TI  - The costo-uterine muscle of the guinea-pig: a smooth muscle attaching the uterus
      to the last rib.
AB  - A conspicuous smooth muscle (of transverse sectional area comparable to that of
      the taenia coli) situated in the suspensorium ovarii and in the ligamentum ovarii
      proprium of the guinea-pig is described. The muscle is attached to the last rib,
      it reaches the medial side of the ovary, to which it is loosely attached; it
      passes beyond the caudal pole of the ovary (from which it receives additional
      muscle bundles), it approaches the oviduct, passing ventral to it, then it
      spreads around it and eventually reaches the distal end of the uterus; this
      muscle (which is here indicated as costo-uterine muscle) is in direct
      continuation with, or transforms itself into, the longitudinal outer coat of the
      uterus.

PMID- 1015629
TI  - Distribution of retinal ganglion cells in five mammalian species (pig, sheep, ox,
      horse, dog).
AB  - In order to ascertain shape and location of the central area, the distribution of
      ganglion cells was measured in whole mounts of the retina from pig, sheep, ox,
      horse, and dog. Although exact comparison of corresponding points of measurement
      in different animals was not possible, the measurements allowed the mapping of
      retinal ganglion cell density, typical for the particular species. In all
      ungulates a streak of high cell density extends along a straight horizontal line,
      dorsal to the optic disc. As a rule a maximum of ganglion cell density is found
      close to the temporal end of the visual streak. In the dog a well demarcated oval
      portion of the streak continues into a short temporal (variable) and a long nasal
      linear arm. The functional significance of these findings is discussed.

PMID- 1015630
TI  - A human embryo of 28 mm crown-rump length with cerebral, esophagotracheal and
      cardiovascular malformations.
AB  - The following malformations were observed in a human embryo of 28 mm crown-rump
      length obtained at operation for tubal rupture in a case of extrauterine
      pregnancy: 1. Secondary anophthalmia with dysplasia and in part aplasia of the
      diencephalon. Rudiments of both eyes and eyestalklike proliferations within the
      diencephalon. No lenses and on the left side only a palpebral fissure. Hypoplasia
      of the right telencephalic hemisphere and of the right side of diencephalon,
      mesencephalon and proximal parts of the medulla oblongata. Pseudotumorous
      proliferations in the diencephalon, in the alar plate of the medulla oblongata
      (protruding into the fourth ventricle) and in the arachnoid. Hypoplasia of the
      right internal, middle, and external ear. Dysplasia and in part aplasia of facial
      osseous elements (cebocephalia). 2. Proximal esophageal atresia with distal
      tracheoesophageal fistula. 3. A Fallot's tetralogy with right-sided aortic arch
      and regressive right-sided ductus arteriosus, tricuspid atresia, hypoplasia of
      the right ventricle with excessive hypertrophy of its wall, and hypoplasia of the
      pulmonary trunk. Single left superior vena cava and abnormal, semicircular course
      of the stems of both coronary arteries.

PMID- 1015631
TI  - The cancellous structure in the calcaneus and its relation to mechanical
      stressing.
AB  - The structure of the cancellous bone in the calcaneus is comparable to a three
      dimensional trajectorial system, best adapted to resisting bending stresses. This
      can be seen from the curve trend of the tensile fascicles. Since stressing takes
      place mainly in the sagittal plane, the adaptation of the structure must be
      examined in this plane. The photoelastic experiments prove that similar
      trajectorial patterns result from different types of loading (e.g., standing with
      and without muscular contraction, the transmission of forces before and after the
      fusion of the tuber apophysis); and therefore the stresses remain the same. The
      trajectorial patterns, already established from the experiments, correspond with
      those of the cancellous structure, which indicates that a state of adaptation
      exists. Using the definition given in Roux's "maximum-minimum" law, this means
      that the bone achieves maximum resistance with a minimum of material. The
      photoelastic experiments can also be successfully applied to a short, skeletal
      element, which has been stressed in a complex manner. Furthermore, the theory of
      causal histogenesis in the supporting tissues can be proved, since the position
      of the epiphyseal center coincides with that of a singular poing (hydrostatic
      pressure) in the trajectorial pattern. A division of the trajectorial pattern,
      into lateral and medial fascicles (as described by T. von Lanz and W. Wachsmuth)
      cannot be seen in the bone sections and consequently cannot be regarded as being
      factual.

PMID- 1015632
TI  - The embryological development and cytodifferentiation of the pars distalis of the
      golden hamster (Mesocricetus auratus). A light and electron microscopic study.
AB  - The embryological development of cytodifferentiation of the hamster pars distalis
      was investigated using light and electron microscope techniques in order to
      obtain basic information for comparison with pituitary development in other
      mammalian species. The normal chronological events in the development of the
      hamster pars distalis closely paralleled the pituitary organogenesis of other
      laboratory rodents. Rathke's pouch formed and touched the infundibulum at 8 1/2
      days of gestation and separated from the stomodeum 3 days later. Penetration of
      vascular elements from the developing hypophysial portal system into the pars
      distalis occurred at 12 1/2 days gestation. This was also the first day that
      small secretory granules were seen in any of the parenchymal cells. Further
      cytodifferentiation during the following prenatal, and first few postnatal days
      of life revealed granulated cells which, in most cases, could not be identified
      using morphological criteria or granule size as may be done in the adult. An
      orderly sequence of inductive and morphological events appears to take place in
      the developing hamster adenohypophysis paralleling similar events observed in
      other animals.

PMID- 1015633
TI  - The distribution of intercellular gap junctions in the developing retina and
      pigment epithelium of Xenopus laevis.
AB  - The distribution of gap junctions in the developing retina and pigment epithelium
      of Xenopus has been examined from optic vesicle to photoreceptor outer segment
      stages. In the retina and pigment epithelium walls of the optic vesicle gap
      junctions are found between ventricular cells in the apical contact zone and
      close to the outside wall; a neural tube type of distribution. Optic cup
      formation brings the retina and pigment epithelium into contact and gap junctions
      form between them. After the stage of retinal specification gap junctions,
      previously more numerous dorsally, are more often found in the ventral retina and
      pigment epithelium. They continue to be found in the retinal centre between
      ventricular cell processes in the apical contact zone and near the vitreal
      basement lamella above the ganglion cell layer until stage 35. Gap junctions are
      occasionally made by ganglion cells and their axons, providing possible pathways
      initiating cell differentiation. After stage 35 gap junctions seem to be confined
      to the peripheral rim of the eye cup where new cells are formed throughout larval
      life. The observed distribution suggests that gap junctions may provide
      intercytoplasmic pathways for retinal specification intrinsic to the retina and
      pigment epithelium.

PMID- 1015634
TI  - [Symposium on macromolecular solutes in blood replacement. Strasbourg, November
      29 and 30. Introduction].

PMID- 1015635
TI  - [Physico-chemical properties of dextran].

PMID- 1015636
TI  - [Pharmacokinetics of dextran].

PMID- 1015637
TI  - [Effect of hemodilution on the rheologic properties of blood and oxygenation of
      tissues].

PMID- 1015638
TI  - [Replacement solutes and oxygen transport: physico-chemical and pharmacologic
      study of their combination with a hemoglobin solution].

PMID- 1015639
TI  - [Effect of various replacement solutes on the uptake of colloidal-size
      particles].

PMID- 1015640
TI  - [Macromolecules and balanced sodium-containing solutions].

PMID- 1015641
TI  - [Hemodilution in normal blood volume. A study of blood gases and acid-base
      equilibrium].

PMID- 1015642
TI  - [Macromolecules and hemorhealogy].

PMID- 1015643
TI  - [Effect of dextran on coagulation and hemostasis phenomena].

PMID- 1015644
TI  - [Modified fluid gelatins and platelet aggregation in vivo in man].

PMID- 1015645
TI  - [Macromolecules and prevention of postoperative thromboembolism].

PMID- 1015646
TI  - [Prevention of postoperative thrombosis with low molecular weight dextran.
      Apropos of a series using a radioactive isotope technic].

PMID- 1015647
TI  - [Macromolecules, the reticuloendothelial system and immunologic problems].

PMID- 1015648
TI  - [Macromolecules and the kidney].

PMID- 1015649
TI  - [Use of macromolecules in a kidney hemodialysis center. Physiopathologic support.
      Protocol for use].

PMID- 1015650
TI  - [Action of Rheomacrodex on placental hemodynamics].

PMID- 1015651
TI  - [Replacement therapy using macromolecules: general hemodynamic effects].

PMID- 1015652
TI  - [Effect of perfusion of low molecular-weight dextran on blood output and cerebral
      metabolism].

PMID- 1015653
TI  - [The place of anti-aggregants and macromolecules in the treatment of cerebral
      artery aneurysms].

PMID- 1015654
TI  - [Effect of low molecular-weight dextran on platelet aggregation in
      atherosclerosis patients].

PMID- 1015655
TI  - [Significance of a modified gelatin polymer in the control of hypovolemia.
      Application to hemodialysis].

PMID- 1015656
TI  - [Undesirable effects of macromolecules].

PMID- 1015657
TI  - [A major intolerance reaction related to the injection of modified fluid gelatin.
      Apropos of 1 case].

PMID- 1015658
TI  - [Use of dopamine in the treatment of shock states].
AB  - The utilisation od dopamine at an average dose of 6 mug/kg/mn, for the treatment
      of 19 shock states, is proved to be of particular interest. The lapic action, the
      special amelioration of the left ventricular function suggest that dopamine is an
      useful drug in the treatment of circulatory failure and myocardial inefficiency.
      The renal and mesenteric vasodilatation produced, prevent or treat the acute
      renal failure of shock. The actions of dopamine are different from those of other
      vasopressive amines (norepinephrine, isoproterenol, glucagon) and make dopamine
      on the first drug to treat shock states.

PMID- 1015659
TI  - [A comparative study of the cardiovascular effect of dobutamine. Preliminary
      results obtained in a surgical resuscitation unit].
AB  - Dobutamine (dobutamin hydrochloride, Lilly) is a new inotropic catecholamine; it
      is presented in lyophilized ampoules for I.V. use, each containing 250 mg of
      dobutamine to be reconstituted with 5 per cent glucose or sterile water for
      injection. In the first part of this study, animal pharmacology is reported as
      described in medical literature: inotropic activity with minimal chronotropic
      effects, direct action, no vasconstriction, minimal arrhythmogenic activity and
      minimal diversion of blood flow to skeletal muscles are the main experimental
      features. The authors report afterwards their own experience with dobutamine in 8
      patients (cranial traumas) without cardiac failure, and in 9 patients presenting
      with a cardio-circulatory failure in a toxi-infectious condition. In all patients
      tested, hemodynamics parameters (heart rate, mean A.P., central venous pressure)
      and cardiac output measurement (dye dilution method) were performed. Cardiac
      index and systolic index, total systemic resistances, left ventricular
      performance were also calculated. Dobutamine dosage ranged from 2.5 to 10
      mcg/kg/mn except in patients with low output syndrom (2.5 and 5 mcg/kg/mn).
      Dobutamine offers new possibilities by its constant and indisputable inotropic
      activity contrasting with its minimal chronotropic effect.

PMID- 1015660
TI  - [Dose ketamine respect the protective reflex of the respiratory tree].

PMID- 1015661
TI  - [Cardiovascular impact of the treatment of postoperative pain in cholecystectomy
      using pethidine and intercostal block. Comparative action].

PMID- 1015662
TI  - [Significance and results of blood volume in burn patients (apropos of 94
      measurements in 41 subjects].

PMID- 1015663
TI  - [Consequences of acute bronchial obstruction caused by the inadequate placement
      of the intubation tube].

PMID- 1015664
TI  - [The analgesic activity of piritramide].

PMID- 1015665
TI  - [Cardiac effect of alfatesine in patients with constant heart rate].

PMID- 1015666
TI  - [Sciatic nerve block by the anterior approach. Its significance. Its limits.
      Apropos of 50 cases]es. A propos de cinquante observations.

PMID- 1015667
TI  - [Preoperative arterial clearing in arterial surgery].

PMID- 1015668
TI  - [Semi-micromethod for the assay of vitamin E. Use in neonatal pharmacology].
AB  - A micromethod using 250 mul of plasma was described for assaying vitamin E. The
      complete extraction of the plasmatic vitamin E was made possible. The sensitivity
      and occurency of this method are particularly suitable in pediatric
      determinations. The vitamin E plasmatic levels were measured in the low birth
      weight newborn given or not a 10 mg vitamin E supply in the feeding.

PMID- 1015669
TI  - [Proposal of a new procedure for the exploration of hepatocellular function. The
      trimethoxybenzene test (TMB)].
AB  - The authors propose a new method of exploration of liver cell function based on
      the study of demethylation of a rapidly assimilated atoxic compound,
      trimethoxybenzene (TMB) in dimethoxy-hydroxybenzene (DMHB). Whereas in normal
      subjects, the urinary excretion of the metabolites was rapid and marked, 180 mg
      within 3 hours after taking a 400 mg dose, in patients with liver cell failure,
      the excretion of DMHB was considerably reduced, 80 to 95% in cirrhosis.

PMID- 1015670
TI  - [The diagnosis of a group of Streptococci. 1 - Comparative study of various
      techniques for the extraction of the polyoside antigen from Streptococci].
AB  - The present importance of streptococcal pathology implicates the identification
      of the streptococcal groups. The authors have carried out a comparative study of
      the various methods of extraction of the group specific antigen. They
      demonstrated the advantages and disadvantages of each method and consider the
      pronase extraction method to be the simplest, the most rapid and the most
      specific.

PMID- 1015671
TI  - [Comparison of values, obtained on heparinised serum or plasma, for common
      biochemical examinations].
AB  - The biologist may prefer to use plasma rather than serum to facilitate sampling
      procedures in his laboratory. It is important to know whether or not the
      patients' results will be affected by this change. In daily practice, there is no
      difference to speak of between plasma and serum for bilirubin, calcium,
      potassium, creatinin, urea, cholesterol, sodium, uric acid, triglycerid and iron.
      There are, however, differences for total proteins, phosphates and glucose.

PMID- 1015672
TI  - [Steroid receptors and hormonal receptivity. New pharmacological and therapeutic
      approaches applicable to the control of fertility].
AB  - The definition and main characteristics of the steroid hormone receptors are
      given. One may note a relationship between hormonal receptivity and the
      physiological changes in the concentration of the receptors in the target organs.
      The distribution of the various receptors is given in detail showing the
      existence of (a) different receptors for the same hormone in different target
      cells; (b) different receptors for different hormones in the same cells; (c)
      different receptors for the same hormone in the same cell. A new pharmacological
      approach is proposed based on differentiation of receptivities from which there
      results a dissociation of the therapeutic effects.

PMID- 1015673
TI  - [Androgen receptors. Their value in physiopathological investigations in man].
AB  - There is less knowledge of androgen receptors than of oestrogen receptors but, in
      recent years, important progress has been made. The author thus describes the
      physico-chemical properties of the androgen receptors. He discusses also the
      problems raised by their estimation. The exchange techniques are practically
      unusable as the androgen receptors are easily destroyed even at 15 degrees C. The
      author proposes and describes another method which isolates the hormone-receptor
      complex with protamine sulphate. He also considers the prospects of these
      receptor estimations in prostatic disease, e.g. androgen-dependent adenoma. The
      absence of androgen receptors in testicular feminisation syndrome finally permits
      excellent illustration of the importance of the study of receptors in the
      understanding of cellular insensivity to a hormone.

PMID- 1015674
TI  - [Insulin receptors: physiopathological implications and applications].
AB  - The study of insulin receptors has permitted important progress in the knowledge
      of various pathological conditions, such as, diabetes, obesity. Studies in recent
      years of the changes in the link between insulin and receptors has proved that
      the receptor may present interesting variations in affinity with regard to
      insulin. The notion of negative cooperativity is thus discussed by the lecturer.
      The number of receptors may also vary. A study of insulin receptors in the
      experimental, genetic or acquired obesity and in human obesity, is very
      instructive. Another point emphasized concerns the use of the receptor for the
      study of structure activity relationships, but also the possibility of estimation
      of insulin according to the principle of radiocompetition by the receptor. This
      method of analysis permits one to study the various forms of hormone in patients.

PMID- 1015675
TI  - [Introduction to pediatric oncology].

PMID- 1015676
TI  - [The role of surgery in the treatment of lymphoma (author's transl)].
AB  - 18 cases of abdominal lymphoma in children are reported. Six survived longer than
      two years after surgery, chemotherapy and radiotherapy. Surgery in lymphoma can
      be useful for diagnosis, staging and when the tumor arises within intestinal
      lumen, for cure.

PMID- 1015677
TI  - [Rhabdomyosarcoma in children (author's transl)].
AB  - 48 cases of embryonal sarcoma are reported. 41.6% of them are currently
      surviving, three for longer than five years, two longer than four, five longer
      than three, five longer than two, and five longer than twelve months. Treatment
      is based on surgery, chemotherapy and radiotherapy.

PMID- 1015678
TI  - [Aniridia associated with gonadoblastoma in Smith-Lemli-Opitz syndrome (author's
      transl)].
AB  - One case of bilateral "in situ" gonadoblastoma associated with aniridia and Smith
      Lemli-Opitz syndrom is reported. This observation confirms the incidence of
      gonadoblastoma in intersex patients. Coincidence of this tumor and aniridia is
      considered by the authors as previously unreported.

PMID- 1015679
TI  - [Surgical approach of retroperitoneal neuroblastoma in infancy (author's
      transl)].
AB  - Rarely retroperitoneal neuroblastoma is a well localized, encapsulated tumor,
      like it my appear somewhere else, as in the pelvic floor or mediastinum. Even
      with the same histological findings they are different from de point of view of
      invasion. Therefore the surgical approach should be different in each case. This
      is our main conclusion after de study performed in 48 cases operated upon in the
      last 8 years. We have tried three kinds of operations. 1. The so called curative,
      total resections. Performing a surgical ablation of the tumor and the organs
      macroscopically involved, either prior or after radiotherapy or quimiotherapy. At
      any risk, even of life in the early postoperative period. This kind of surgery
      has been undertaken in 34 cases with an early mortality of 9. The main aim of
      this technique is to divide the tumor in two across the supraaortic line well
      below the renal vessels and up to the diaphragm. In 18 cases the homolateral
      kidney was resected with the suprarrenal gland. Spleen and pancreas in 5 cases,
      colon in 4, and the inferior vena cava in 3. The survivors over 2 years are 19
      cases. 2. Paliative resection, taking out the main tumor only, has been achieved
      in 4 cases, with the highest mortality because postoperative hemorrhage. We
      believed is a dangerous procedure. None of these children survived more than one
      year. 3. Biopsy and surgical macroscopic diagnosis of invasion plus placing clips
      at their margin has been carried out in 12 occasions. This had naturally the best
      early postoperative but not in the long run, none survived more than 2 years. A
      second look up with resection was undertaken in 3 cases with mortality of one.
      Most surgeons are puzzled when dealing with retroperitoneal neuroblastoma and
      some how disappointed before undertaking a long, difficult and highly risk
      operation, but in many instances still is about the only hope they may have.

PMID- 1015680
TI  - [Treatment of neuroblastoma with transfer factor (author's transl)].

PMID- 1015681
TI  - [Craneopharyngioma in children (author's transl)].
AB  - Clinical findings in the initial and developed stages were studied in 33 cases of
      craneopharyngiomas in children under sixteen. A predominance of intracraneal
      hypertension symptoms and sight defects over endocrine symptoms was discovered;
      the latter appearing later on or only being detected after exhaustive studies.

PMID- 1015682
TI  - [Thyroid papillary adenocarcinoma (author's transl)].
AB  - A case of papillary adenocarcinoma of thyroid is reported in a 13 years old boy.
      The clinical and pathological features are discussed and the pertinent literature
      is reviewed.

PMID- 1015683
TI  - [Thyroid cancer in childhood (author's transl)].
AB  - The authors present three cases of thyroid cancer in the child with comments on
      the etiologic, clinical and therapeutic aspects of this rare disease. The authors
      insist on the danger of local radiotherapy and on the need to suspect thyroid
      cancer in cases of persistent laterocervical adenopathies whose diagnosis can
      only be confirmed by means of a biopsy. It is of note that the illness took a
      favourable course and various therapeutic criteria are discussed.

PMID- 1015684
TI  - [Local treatment of angiomas with corticoids (author's transl)].
AB  - The angiomas studied at the Clinica Infantil "La Fe" in a four and a half years
      period are reviewed. The different therapeutic approaches are considered.
      Thirteen cases selected at random have been treated with local injections of
      steroids, with a 84% satisfactory results. The technique seems to be simple and
      without complications. It is recommended in the management of the parotideal,
      small size, subcutaneous and those angiomas in which the therapy could be
      followed by sequelae and in those where other therapy has failed.

PMID- 1015685
TI  - [Correlation between scanning,  Radiological images and clinical findings in
      tumoral processes (author'a transl)].
AB  - During last years bone scanning has shown a great accuracy in the diagnosis of
      primitive bone tumors and bone metastasis in adult patients. With the use of
      short lived tracers this technique has also been used in Pediatrics. The authors
      present their experience in the evaluation of bone scanning in 31 patients with
      different tumoral processes doing a correlation between scanning, radiological
      images and clinical findings. The technique is presented for discussion showing
      its possibilities, limitations and future of its application in Pediatrics.

PMID- 1015686
TI  - [Hemihepatectomy with I.V.C. by-pass. Experience of 11 cases (author's transl)].
AB  - 22 malignant tumors of the liver in children have been treated so far at the "La
      Paz" Childrens Hospital. 11 cases underwent hemihepatectomy with intracaval by
      pass. This technique is described and its advantages underlined.

PMID- 1015687
TI  - [Treatment of one case of severe laryngeal papillomatosis (author's transl)].
AB  - One observation of severe laryngeal papillomatosis is reported. After diagnosis
      by biopsy and tracheostomy the patient was treated with bleomycin and thio-tepa
      associated with punch extirpation of residual papillomata following Kleinsasser.
      Results at two and half years were excellent.

PMID- 1015688
TI  - [Isolation and intestinal sterilization in prevention of infection in patients
      with malignant diseases (author's transl)].
AB  - Results obtained by isolation and intestinal sterilization in prevention of
      infections in 42 patients with malignant diseases are shown. A substantial
      decrease of infection is observed, as compared with a control group of 33
      patients with similar disease, treated in normal hospital conditions. The problem
      of intestinal sterilization is discussed and literature on this subject revised.

PMID- 1015689
TI  - [Our experience in pediatric oncology (author's transl)].
AB  - An initial statistical study on the incidence of oncologic pathology during
      infancy carried out in the Pediatric Department of the University of La Laguna,
      is presented. They study includes 33 tumors which have been collected over a
      period of 3.5 years.

PMID- 1015690
TI  - [Tumor committee and pediatric oncology. Importance for management of infantile
      neoplasias (author's transl)].
AB  - The organization for the diagnosis, treatment and follow-up of the children with
      malignancies at the Hospital Infantil "Virgen del Rocio", are described. There is
      a Tumor Committee made up by two pediatrics oncologist, two pediatrics surgeons,
      one pathologist, one radiotherapist, one pediatric psiquiatrist and one social
      worker. The Oncology Section of the Hospital is made up by one pediatric
      oncologist and one registerers nurse (A.T.S.) and several clinical assistants.

PMID- 1015691
TI  - [Psychological approach in pediatric oncology (author's transl)].
AB  - An attempt to describe the procedures with fatally ill children, from a
      psychotherapeutic point of view is made. Special attention is paid to selecting
      nursing staff assigned to those children, requiring highly human and professional
      qualifications. Children with mild or severe psychopathological reactions, and/or
      their parents, are referred to Psychiatric Services for individual and/or family
      therapy. At the same time, group therapy is carried with parents. Finally,
      parents are followed in order to prevent unwanted psychopathological reactions
      after death of the child.

PMID- 1015692
TI  - Ten-year experience with childhood rhabdomyosarcoma.
AB  - The ten-year (1965-1975) experience of the Pediatric Tumor Clinic with 14 cases
      of proven CRM was reviewed. Seven cases seen prior to 1970 acted as control. They
      were treated by surgery and X--ray therapy alone (one received one
      chemotherapeutic agent). Seven other cases seen after 1970 adhered to a strict
      protocol of therapy. After surgery (resection or biopsy), roentgenological and
      hematological survey for diagnosis and staging, they received curative
      radiotherapy locally in doses of 5,200 r to 6,000 r. Concomitantly a regimen of
      multiple chemotherapeutic agents (vincristine, dactinomycin and cyclophosphamide)
      was administered according to the protocol followed at the M.D. Anderson
      Hospital, Houston. Only one of the seven controls is alive and free of disease
      for 9 years. Only one of the seven cases who adhered to the protocol died. The
      other six are alive and free of disease for periods of one to two and a half
      years (one has a 4 months follow-up so far). One of the six cases presenting with
      a solitary pulmonary metastasis had a lobectomy 2 and a half years after start of
      treatment, as no new metastasis developed. Another, presenting with a local
      recurrence after excision is alive and free of disease 2 years after the star of
      treatment with the protocol. The results of treatment of CRM with the protocol
      adopted show a significant improvement in terms of local recurrences, distant
      metastasis and survival rates.

PMID- 1015693
TI  - The radiographic evaluation of 105 consecutive children with Hodgkin's disease.

PMID- 1015694
TI  - Teratomas in childhood.
AB  - Of 109 teratomas in children 86 were benign and 23 malignant. Sacro-coccygeal and
      pelvic teratomas predominated 52 cases, and these fell into three groups, post
      sacral, dumb bell and pre-sacral. The 34 purely posterior tumours were always
      congenital and benign whilst the incidence of malignancy in dum bell and pre
      sacral teratomas increased as the tumour became more internal. Other sites
      affected in order of frequency were: the gonads, head and neck, retroperitoneal
      anterior mediastinum and the central nervous system. Malignant teratomas were
      carcinomas usually containing glandular, capillary and clear cell areas, and
      metastases were similar. Immature tissues in benign teratomas were usually neural
      or connective tissue. They did not give rise to neuroblastomas or sarcomas and
      did not indicate a worse prognosis. Only two originally benign teratomas later
      developed malignancy.

PMID- 1015695
TI  - Medulloblastoma of the cerebellum.
AB  - On the base of 77 medulloblastomas of the cerebellum, it is a point out the
      actual management of children with medulloblastoma which can be summed up as a
      combination of surgery to relieve pressure and remove as much of the tumor as
      possible, para-operative vincristine, radical treatment of the whole C.N.S. by
      radiotherapy followed by maintenance chemotherapy of B.C.N.U. and vincristine.

PMID- 1015696
TI  - [Adenocarcinoma of the anus. Therapeutic considerations].

PMID- 1015697
TI  - [Apropos of 3 cases on so-called primary steonsing papillitis].

PMID- 1015698
TI  - [Correlations between lymphadenographic and laparotomic findings in Hodgkin's
      disease].

PMID- 1015699
TI  - [Testicular neoplasms: some aspects of fluorescence microscopy].

PMID- 1015700
TI  - [Indications and results of uretero-ureteral "Y" anastomosis. Clinical review].

PMID- 1015701
TI  - [Study on the relations between pulmonary atelectasis and arterial PaO2 in
      abdominal surgery of aged patients].

PMID- 1015702
TI  - [Clinico-statistical findings on hepatic echinococcosis. Considerations on 128
      surgically treated cases].

PMID- 1015703
TI  - [Transanastomotic catheterization in the control of portacaval derivations].

PMID- 1015704
TI  - [Primary adenocarcinoma of the vermiform appendix].

PMID- 1015705
TI  - [Sclerosis of the bladder neck within the framework of cervico-urethral
      "dysectasia"].

PMID- 1015706
TI  - [Duodenal lesions caused by closed abdominal injuries].

PMID- 1015707
TI  - [Recent research on the function of the kidney in the catabolism of gastrin].

PMID- 1015708
TI  - [Portacaval anastomosis in cirrhotics with portal hypertension: summary of
      personal experience].

PMID- 1015709
TI  - [Tube prostheses in the palliative treatment of cancer of the espophagus and
      cardia].

PMID- 1015710
TI  - [Profile of traumatic cardiopathies caused by blunt thoracic injuries].

PMID- 1015711
TI  - [The phytobezoar: an anatomic and historical curiosity].

PMID- 1015712
TI  - [Use of streptokinase in the treatment of venous thrombosis and arterial
      thromboembolism of the lower limb].

PMID- 1015713
TI  - Investigations of red cell glyoxalase in recombinant families.
AB  - The polymorphism of the red cell glyoxalase (GLO), which has recently been found
      to be linked with the major histocompatibility complex (HLA) in man, was
      investigated in a number of selected families showing various recombinations
      between HLA-A, HLA-B and the third locus of the phosphoglucomutase (PGM3). In two
      families with a recombination between HLA-A and HLA-B, the GLO allele travels
      with the HLA-B locus fragment of the chromosome, indicating that GLO is located
      on the side of the HLA-B locus. In other families, recombinations occurred
      between HLA-A and B on one side and GLO and PGM3 on the other side, demonstrating
      that GLO and PGM3 are located on the same side of HLA. Other recombinations
      separated PGM3 from GLO so that it can be assumed that GLO is located between HLA
      B and PGM3. Thus the immunogenetic linkage group on human chromosome C6 has been
      increased by yet another outside marker gene to include now the following genes
      in this order: HLA-A--HLA-C--HLA-B--Bf--HLA-D--GLO--PGM3.

PMID- 1015714
TI  - [3 cases of trichinosis].

PMID- 1015715
TI  - [Apparent spontaneous rupture of the myocardium. A case of false ventricular
      aneurysm treated surgically in a 56-year-old patient with aortic coarctation].

PMID- 1015716
TI  - [Sensitivity of the Notezine test in onchocerciasis (apropos of 25 personal
      cases].

PMID- 1015717
TI  - [Progressive polyserositis complicating a case of biologically stabilized
      rheumatoid arthritis. Constrictive pericarditis treated by pericardectomy].

PMID- 1015718
TI  - [Pelvi-spinal and spinal localizations of Besnier-Boeck-Schaumann's sarcoidosis].

PMID- 1015719
TI  - [Developmental aspects of angioimmunoblastic lymphadenopathy. Apropos of 3
      cases].

PMID- 1015720
TI  - [Importance of echocardiography in aortic valve disorders].
AB  - It would seem that, despite certain limitations, echocardiography may be
      considered to be an important method of investigation in the diagnosis and
      prognosis of aortic valve disease. Quantitative measurements may possible study
      of the progression of the lesions. Nevertheless, echocardiography only appears to
      be a simple technique and emphasis should be placed on the importance of a
      complete investigation as well as the quality of the recordings to be studied.

PMID- 1015721
TI  - [Anatomo-pathologic forms of lymphoid and lymphoreticular fibrosis of the bone
      marrow].
AB  - The development, within the bone marrow, of reticulo-fibrosis with a lymphoid
      organ structure forms part of a pathological model common to several lympho- and
      reticulo-proliferative syndromes. Various cytological types develop within this
      reticulo-fibrous framework: lymphocytes, lymphoblasts, plasmocytes, "hairy cells"
      and histiocytes. This cytological variety has led to different names: leukaemic
      reticulo-endotheliosis, lymphoid myelofibrosis, histio-lymphocytosis, malignant
      histiocytosis, etc. Similar cell type sequence is seen in non-Hodgkins lymphomas,
      with the same problems of parent and daughter cells. In fact the architectural
      metaplasia of the bone marrow prevails over the cellular metaplasia in the
      definition of the single clinical, haematological nature and course of these
      syndromes which have been too widely dissociated by classical haematology.

PMID- 1015722
TI  - [The role and functions of the lung in equilibrium of the internal milieu.
      Protein metabolism and enzyme systems].
AB  - The different anatomical zones of the lung show a high degree of variation in
      metabolic function, involving many protein molecules and complex enzyme systems.
      Recent data in the literature concerning such activity are described with respect
      to bradykinin, fibrinolysis, haemostasis, angiotensin, serotonin, catecholamines,
      prostaglandins, vaso-active amines, the protease-antiprotease system and
      benzopyrene-hydroxylase.

PMID- 1015723
TI  - [Rheology of bronchial secretion and muco-ciliary clearance. Preliminary
      remarks].

PMID- 1015724
TI  - [Defenses of the respiratory system against bacterial infection and its
      disturbances].

PMID- 1015725
TI  - [Principal morphologic data on the pulmonary metabolism of biogenic amines].

PMID- 1015726
TI  - [Insufficiency of secretion from the exocrine pancreas in infants (excluding
      mucoviscidosis) Diagnosis and consequences].
AB  - The diagnosis of insufficiency of exocrine pancreatic secretion was made in two
      infants after demonstration of a marked decrease in the flow rate of enzyme
      secretions during the duodenal infusion of milk and after the IV injection of
      C.C.K.-P.Z. The two infants had a normal sweat test. One had pancreatic
      lipomatosis with neuropaenia, whilst the other had pancreatic deficiency which
      did not fall into the context of Shwachman's syndrome. This study suggests that
      the absence of exocrine pancreatic secretion is accompanied by multiple
      abnormalitites : decreased absorption of fats and vitamin B12 and, it would
      appear, variations in certain activities of the jejunal mucosa and decreased
      insulin stimulation from the intestine. Such a situation reflects the complexity
      of the relations established between the organs participating in the processes of
      absorption and digestion.

PMID- 1015727
TI  - [A radioisotope test of muscular function (skeletal)].
AB  - A new radioisotopic method measuring the alterations in local blood volume of a
      muscle before, during and after exercise would seem to make possible the
      detection of frankly pathological muscular irrigation. The latter is
      characterised by a marked reduction in blood volume during effort, with or
      without slight secondary hyperhaemia. Given the correlation between flow and
      volume, the state of the blood flow may be deduced, and probably to follow the
      spontaneous progression of progress with treatment of the vascular problem and to
      assess its prognosis.

PMID- 1015728
TI  - [Programmed induction of labor by prostaglandin F2 alpha].

PMID- 1015729
TI  - [Nephrotic syndrome and hypersensitivity to pollens].

PMID- 1015730
TI  - [Isolated abolition of a lower abdominal cutaneous reflex, a sign localizing
      pheochromocytoma (5th case) Reappearance of the reflex after exeresis of the
      tumor].

PMID- 1015731
TI  - [A case of megaesophagus occurring with an emotional shock. Remarkable action of
      sulpiride on the dysphagia after failure of 2 Heller operations].

PMID- 1015732
TI  - [Eating behavior in degenerative dementias or mixed dementias with a predominance
      of degeneration in old age].

PMID- 1015733
TI  - ["Analysis of fate" in psychiatry and psychotherapy. II. Correlations withe the
      level of general psychopathology].
AB  - We demonstrated in a group of 166 psychiatric patients, with disorders of
      schizophrenic and cyclothymic circle and with neuroses too, significant relations
      between the results of the projection test of Szondi and between the greatness of
      total psychopathology, evaluated by means of the Minnesota Multiphasic Inquiry
      (M.M.P.I.). We could ascertain, that the patients with the higher level of total
      psychopathology (evaluated by means of M.M.P.I.) have also a greater number of
      abnormal results according to the projection test of Szondi. At these patients we
      saw significantly more "valve groups", which witness to the irresolution in the
      instinctive motivations of behaviour. At these patients we could ascertain
      further the greater number of those personalities, which according to the
      projection test of Szondi suffered from a lack of breaking and self-critical
      elements in their behaviour. Subjects with heightened values of M.M.P.I. have
      significantly more results with abnormal relations of masculinity and of feminity
      according to the sexual index of Szondi test. The choices and the selection from
      the set of 48 fixed photographies, which the patient realises at the Szondi test
      in teen repeated sessions, form so a significant relation not only to the
      psychiatric diagnoses, as was ascertained in the first part of this work, but
      also to the height of total psychopathology, evaluated by means of the M.M.P.I.
      The familial subconsciousness influences so significantly the consciousness of
      personality and can participate substantially in the development of
      psychopathologic symptoms.

PMID- 1015734
TI  - [Psychiatric aspects of Steinert's disease with neonatal onset].

PMID- 1015735
TI  - [Psychiatric aspects of modern drug addiction].
AB  - The author did beforehand a brief historical survey of drug usage, going throught
      the concepts of what might be called classic drug addiction, until the present
      stage of the phenomena of what is known as contemporary drug addiction was
      reached. Accepting the clinical reality of psychiatric accidents, as presented by
      the classic psychiatric nosological classification as a fact, the author points
      out the possibility for establishing a relation between the misuse of
      toxicomanogenic substances and the frequently pre-morbid personality of the user.

PMID- 1015736
TI  - [Kidney failure, hemodialysis and psychiatric problems].

PMID- 1015737
TI  - [Nitrosamines. Review].
AB  - Nitrosamines are an extremely carcinogenic class of compounds. The hasard, bound
      with the occurrence of this compounds in the food and the possibility to be
      formed in vivo, during the digestion, justifies the current works. The authors
      quoting numerous works on different laboratory's animals, remind the toxicity.
      and carcinogenicity of this compounds. The metabolism is also discussed. The N
      nitroso, compounds may be formed in food from the presence of the precursors
      (nitrite or nitrate, amines and amino-acides). The synthesis takes place during
      the technological processes, the storage and the house cooking. Today, the
      marginal effect dose is estimated as 10 mug/kg of daily food. The carcinogenicity
      has not been demonstrated in human, but is strongly suspected. The amount of N
      nitroso compounds in human food is generally low. Many factors can influence the
      reaction; it is inversely related to the basicity of secondary amine and optimum
      pH is around pH 4. A lot of compounds such as sodium ascorbate inhibit the
      synthesis in food. A number of recent reports using reliable methodology have
      identified nitrosamines at the lower part per billion level. Dimethyl
      nitrosamines occurs, very sporadically in a number of cooked meat samples. The
      nitrosopyrrolidine appears frequently in fried but not in uncooked products. The
      nitrosopiperidine seems to be bind with the presence of pepper in food. Finally
      the presence of nitrosamides (nitrososarcosine) and nitrosoaminoacides
      (nitrosoproline, nitrosohydroxy-proline) is being quested. The N-nitroso
      compounds may be synthetized in vivo during the digestion at the acide medium of
      the stomach or by bacterial action during the transit in the gut...

PMID- 1015738
TI  - [Influence of a low-protein diet on the acute toxicity of a pesticide: Nabam].
AB  - Male rats are fed during twenty eight days from the weaning with semi-synthetic
      isocaloric diets containing 3,5 p. 100 and 26 p. 100 of proteins under the from
      of casein and with a standard laboratory diet. At the end of this period the LD50
      and the pathological clinical syndrome of a fungicid belonging to the
      dithiocarbamate series : the Nabame, are determined in each of the groups of rats
      receiving their respective diet. The LD50 is significantly reduced among the rats
      with a deficiency in proteins compared with the LD50 determined among the two
      other groups of animals. A likely explanation is to be looked for, at least for a
      part, on the level of the production or of the activity of detoxicating
      microsomal hepatic enzymes which the restrictions of nitrogen supply could
      reduce. The pathological - clinical syndrome of toxicity : stimulation then
      depression of the central nervous system, severe inflammation of the gastro
      intestinal tract, important renal necrosis, is essentially the same among all the
      animals and it does not seem to be influenced by the level or nature of the
      proteinic supply.

PMID- 1015739
TI  - [Diminution of activity of liver microsomal oxygenase in a rat fed with a diet
      with added zineb].
AB  - Young Wistar CF male rats were fed with diets containing 6,15,60,600,3600 p.p.m
      of zineb (a zinc thiocarbamate used as fongicide). Four weeks after the beginning
      of the treatment, a calcic precipitation method is used for obtaining a
      preparation of liver microsomes from these animals. The microsomes are then used
      for measuring the activity of both aminophenazone demethylase and aniline
      hydroxylase as well as the liver concentration of cyt. P 450 and cyt. b5. The
      weight growth was reduced by the highest dose of zineb, which corresponds to
      about a daily intake of twentieth of the LD 50 per os. The fongicide brings down
      the activity of the microsomal monoxygenases and reduces the P 450 quantity. The
      lessening of the aminophenazone demethylation is apparent starting from a dose
      between 60 and 600 p.p.m...

PMID- 1015740
TI  - [Nutritional effects in the rat of oxythioquinox (morestan) as a function of its
      concentration and of the lipid content of the diet].
AB  - Of two groups of rats, one received a normal diet and the other a high fat diet
      for 5 weeks. The effects of oxythioquinox, administred at diet concentration of
      200, 400 and 800 mg/kg, of fresh food are studied on weight gain, food and
      calorie intake and on the weight and composition of various organs. Growth, food
      and calorie intake are diminished in relation to oxythioquinox concentration in
      the diet. There exist an interaction between the fat content of the diet and the
      toxicity of oxythioquinox. The decrease of the efficiency of calorie by
      oxythioquinox indicates a perturbation of the rats metabolism. An increase in the
      weight of the liver is observed with a significant interaction between the fat
      concentration and the oxythioquinox with the results expressed in weight of organ
      per 100 g body weight. There is an increase in the degree of the water content of
      the animals liver with normal fat diet. In the case of a high fat diet there is
      an increase of cholesterol and fatty acid content. In all case, the variations
      are more strongly marked in relation to the oxythioquinox concentration of the
      diet and at the same concentration, the high fat diet is more effective that the
      normal diet. There is an interaction between the lipids in the diet and the
      oxythioquinox and this interaction indicates, an accentuation of the effects of
      oxythioquinox by lipids of the diet.

PMID- 1015741
TI  - Central retinal vein occlusion: life and sight implications.
AB  - Central retinal vein occlusion is an ophthalmic disease with both life and sight
      threatening implications. Treatment should be aimed at the underlying ophthalmic
      or systemic disease. Questionable modes of therapy (ie, anticoagulation) may
      injure the patient as a whole without offering any really better results for the
      ophthalmic condition.

PMID- 1015742
TI  - Auto-ophthalmodynamometry.

PMID- 1015743
TI  - Fluorescein angioscopy: techniques of partial fluorescence, permanent drawing
      record and photocoagulation.
AB  - Fluorescein angioscopy with the indirect ophthalmoscope might be the preferred
      technique for evaluating and treating certain lesions, particularly those in the
      retinal periphery. Three techniques which are helpful in extending the advantages
      of angioscopy are described. (1) Partial fluorescence is achieved with careful
      adjustment of the cobalt blue filter which relates the fluorescence to retinal
      landmarks, ie, color angioscopy. (2) A permanent record of angioscopy in
      different phases can be made with tracing paper over the retinal drawing. (3)
      Correct localization of lesions to be coagulated is achieved with blue filters
      over the coagulator beam following fluorescein injection. The filter is removed
      during coagulation.

PMID- 1015744
TI  - Vitreoretinal and anterior segment surgery through the pars plana: Part II.

PMID- 1015745
TI  - [Reports on the organization of obstetric-pediatric services and studies on the
      province of Varese].

PMID- 1015746
TI  - [Proposal for a national study group on ovarian carcinoma].

PMID- 1015747
TI  - [The Lombardy Society of Obstetrics and Gynecology: oral ballot on the problem of
      abortion].

PMID- 1015748
TI  - [Clinicacy].

PMID- 1015749
TI  - [Clinico-statistical research in perinatal medicine. Pilot project of a "medical
      card computerized record system].

PMID- 1015750
TI  - [Antepartum cardiotocography and fetal condition at birth].

PMID- 1015751
TI  - [Clinical and therapeutic trends in the treatment of hydatidiform mole].

PMID- 1015752
TI  - [Amniography and fetography: 2 frequently complementary diagnostic technics].

PMID- 1015753
TI  - [Effects of the age factor in dysplasia and preinvasive and invasive cancer of
      the cervix uteri in the Parma area].

PMID- 1015754
TI  - [Double neoplasia of the cervix uteri: epidermoid carcinoma and adenocarcinoma].

PMID- 1015755
TI  - [Clear cell adenocarcinoma of the myometrium. Mesonephric carcinoma].

PMID- 1015756
TI  - [Personal experience with pancuronium in gynecologic surgery].

PMID- 1015757
TI  - [A Piperaceae from Guiana, Peper marginatum Jacq].

PMID- 1015758
TI  - [Microdetermination of organic bases by atomic absorption. I.--Determination of
      quaternary ammonium compounds].

PMID- 1015759
TI  - [A method for counting mastocytes in rat peritoneal lavage fluid].

PMID- 1015760
TI  - [Some pharmacologic properties of a vasoactive combination].

PMID- 1015761
TI  - [Tobacco in the army].

PMID- 1015762
TI  - [Echogarphy in the investigation of silent kidneys and solid renal masses
      (author's transl)].

PMID- 1015763
TI  - [The true lateral view of the patellar facets. A new radiological approach of the
      femoro-patellar joint (author's transl)].

PMID- 1015764
TI  - [Angiographic assessment of patients who received circulatory assistance: with
      reference to 51 cases (author's transl)].

PMID- 1015765
TI  - [Radiological study of trisomy 8 mosaicism (author's transl)].

PMID- 1015766
TI  - [The contribution of phlebography to the detection and the prevention of deep
      venous thrombosis in patients with leg trauma (author's transl)].

PMID- 1015767
TI  - [Isotopic cisternography, Its clinical value (author's transl)].

PMID- 1015768
TI  - [A dosimetric study during cardiac angiography in young children (author's
      transl)].

PMID- 1015769
TI  - [Our experience of humeral arteriotomy in children (80 examinations) (author's
      transl)].

PMID- 1015770
TI  - [The Larsen syndrome. With reference to three new cases (author's transl)].

PMID- 1015771
TI  - [Per-urographic renal extravasation (an unusual paediatric case) (author's
      transl)].

PMID- 1015772
TI  - [Recent dislocation of the acromio-clavicular joint (author's transl)].

PMID- 1015773
TI  - [Acute osteomyelitis of the sternum. Report of a case in an infant (author's
      transl)].

PMID- 1015774
TI  - [The early detection of skeletal metastases in breast cancer patients by
      scintigraphy (author's transl)].

PMID- 1015775
TI  - Elective surgical treatment of duodenal ulcer. Choice of a technique (author's
      transl).

PMID- 1015776
TI  - [Intestinal obstruction due to bezoar. Report of 8 cases (author's transl)].

PMID- 1015777
TI  - [Partial left block and its extent (author's transl)].

PMID- 1015778
TI  - [Myocardial infarction of traumatic origin: a description of three cases
      (author's transl)].

PMID- 1015779
TI  - [Hyperuricaemia and stenotic coronary atherosclerosis. A description of 214
      recent cases of myocardial infarction (author's transl)].

PMID- 1015780
TI  - [Continual electrocardiography in industrial medicine related to job study and
      screening for cardiopathies. A study involving 155 cases (author's transl)].

PMID- 1015781
TI  - [Clinical and radiological aspects of pheochromocytomas (author's transl)].

PMID- 1015782
TI  - [Primary aldosterone syndrome (author's transl)].

PMID- 1015783
TI  - [Electrocardiographic study of the action of amiodarone on intracardiac
      conduction in humans. Comparison between intravenous and oral administration
      (author's transl)].

PMID- 1015784
TI  - [Paradoxical atrioventricular block and left branch block (author's transl)].

PMID- 1015785
TI  - [Late dysfunction of ball mitral valve prosthesis by obstruction of the exit
      opening. Hemodynamic and echocardiographic diagnosis].

PMID- 1015786
TI  - Assay of parathyroid hormone in human serum and its uses.
AB  - The assay of parathyroid hormone has contributed greatly to our understanding of
      calcium metabolism in health and disease. The most important clinical application
      of the assay is in the differential diagnosis of hypercalcaemia, which is an
      increasing clinical problem. PTH assays are of little or no value in the absence
      of other biochemical data, especially accurate determinations of plasma calcium
      and phosphate.

PMID- 1015787
TI  - Hypercalcaemia and malignancy.

PMID- 1015788
TI  - [Analytical and analogical study of a model of the adrenal-postpituitary function
      (author's transl)].
AB  - After an analyitical study of mathematical models connected with osmotic or
      volemic regulations, and the mention of its contribution to the therapeutic act,
      the authors approach the stimulation, by the mean of an analogical computer, of
      the complete and non-linear model which associates both types of regulation. So
      it is possible to attempt to determine the level of adrenal and vasopressin
      actions according to: 1 degree the sum of the agonistic effects and the
      difference of their antagonistic effects; 2 degrees the perturbations brought to
      the system; 3 degrees the parametric values of the model. Theoretical and
      empirical curves seem to be in favour of such a formulation.

PMID- 1015789
TI  - [Proposed new treatment for excessive statural growth using minimal
      corticotherapy. A propos of 11 cases treated with prednisone].
AB  - Treatment for excessive growth has alway constituted, in the endocrinological
      field, and particularly in the United States where such problems are frequently
      encountered, an incompletely solved problem, where the use of oestrogen therapy
      for girls has given more or less convincing results. We believe we have found a
      better solution which comes closer to tackling the real problem by using a minima
      corticotherapy, delayed until a height 1 or 2 cm short of the desired height is
      reached and bridging the time later required for the conjugation cartilages to
      fuse, under the influence of physiological puberty which is allowed to occur
      naturally under this method. 11 adolescents (1 boy, 10 girls) underwent this
      treatment at ages between 12 1/2 and 16 (average age 14 years 2 months), at a
      standard dose of 15 mg/day of prednisone in 3 equal doses over a period of
      between 7 and 25 months with periodical checking of the clinical condition,
      radiological bone structure and satisfactory biological tolerance. Results on
      growth were quite clear: growth rhythm was immediately inhibited, falling from
      7,2 cm to 0,5 cm/year and there was total arrest of expected growth and a final
      height of about 1 or 2 cm more than the height at the onset of treatment was
      reached. The quality of the results obtained by this method seems to be
      considerably better than those obtained by other methods which have so far been
      suggested and this is all the more important as, provided specialised clinical
      and biological checks are carried out very regularly, it is not countered by
      unfortunate side-effects. Side-effects either do not occur at all with this
      method or are very minor and always regress when treatment is terminated.

PMID- 1015790
TI  - [Clomiphen-test in anovulatory sterility (author's transl)].
AB  - Twenty women with sterility due to an anovulatory cycle, were submitted to a load
      of hundred milligramms by day of clomiphene citrate during five days. The test
      was always performed between the 10th and the 14th day of the cycle. Before and
      after the clomiphene administration, FSH and LH in plasma and total estrogens and
      pregnanediol in 24 hours urine, were estimated. The results, are compared with
      those of ten normal women and the observed results may schematically been
      classified into three groups: A) Normal response. -- B) Week gonadotropic
      response. -- and C) High LH baseline. This results seem to indicate three main
      origines for the anovulatory cycle syndrome: hypothalamic, pituitary and ovarian.

PMID- 1015791
TI  - [Influence of the thymus-adrenal interaction on the allograft rejection in rats
      (author's transl)].
AB  - Adrenalectomy was followed in young male Sprague-Dawley rats by a delayed
      rejection of D-A skin grafts. This could be suppressed by implantation of both
      corticosterone and DOC pellets only. Thymic hormone injections did not interfere
      with this action of the corticosteroids.

PMID- 1015792
TI  - [Recurrent hyperaldosteronism and hypertension post adrenalectomy (author's
      transl)].
AB  - Primary Aldosteronism may be due to adenoma or hyperplastic adrenals. Such a
      distinction can be obtained from biochemical studies. In our observation, a man
      with recurrent aldosteronism after right adrenalectomy was studied. Radiological
      and surgical data might indicate an adenoma. This opinion was modified by
      pathological studies. This absence of capsule and the presence of
      microadenomatous hyperplastic lesions indicated pseudo-adenomatous hyperplastic
      glands. On the other hand, high blood pressure remained after adrenalectomy. A
      treatment with beta-blocking substances corrected this hypertension.

PMID- 1015793
TI  - [Antiandrogenic effect of spirolactones: different mechanisms of action (author's
      transl)].
AB  - The spirolactones decrease the plasma testosterone levels in men. They also
      inhibit the specific dihydrotestosterone binding to rat prostate, and have no
      effect on 5 alpha-reductase. The spirolactones are antiandrogenic drugs, acting
      at several levels.

PMID- 1015794
TI  - [Feminishing adrenal tumor with primary hyperaldosteronism. Report of a case
      (author's transl)].
AB  - A case of feminishing adrenal tumor with primary hyperaldosteronism is reported.
      The aim of this report is to emphasize on the terminal evolution of the disease.
      This phase was marked by malignant hypertension, severe renal insufficiency, and
      iatrogenic cellular hyperhydration with hyponatremia secondary to spironolactone
      therapy.

PMID- 1015795
TI  - [Cutaneous manifestations in disseminated intravascular coagulation syndrome].
AB  - The principal cutaneous manifestations indicating the need to seek intravascular
      coagulation are: purpura fulminans, extensive sheets of purpura, acralcyanosis,
      gangrene in a plaque distribution and perhaps, acute necrosis of the digits. The
      biological, anatomo-pathological and immunological signs of the conditions should
      be detected early and precisely by virtue of its nature as a medical emergency.
      The diversity of its clinical manifestations would seem to be related to the
      greater or lesser extent of the coagulopathy and resultant thrombosis in the
      microcirculation. Purpura, though of variable degree, is the constant cutaneous
      accompaniment of this condition, which is considered to be the equivalent of the
      experimental phenomenon of Sanarelli-Schwartzman. Heparin, which blocks the
      tendency to thrombosis in the small vessels in the treatment of choice,
      associated when possible with treatment of the underlying aetiology.

PMID- 1015796
TI  - [Histopathology of cutaneous aphtha in Behcet's syndrome].
AB  - The authors studied cutaneous biopsies of papulo-pustular lesions in Behcet's
      syndrome. In biopsies taken early, superficial oedema of the dermis appeared to
      be the first histological sign, subsequently resulting in a true sub-epidermal
      bulla, containing neutrophil polynuclear and eosinophil leucocytes. At this stage
      no major vascular involvement was seen. In later specimens, by contrast, marked
      vascular changes were seen with the appearances of allergic angiitis. At this
      stage, there is frank epidermal necrosis with resultant ulceration.

PMID- 1015797
TI  - [Dermatomyositis with spinulosis (Wong type dermatomyositis). Histologic study.
      Attempt at pathogenic interpretation].
AB  - The authors present a case of dermatomyositis with generalised spinulosis of
      pilose pityriasis rubra (lichen ruber acuminatus) type, giving a highly
      characteristic appearance of linear verruciform spinulosis of the back of the
      hands. They describe the histological lesions and feel that this spinulosis is
      probably due to marked degenerative smooth muscle myositis of the erector pili
      muscles. They recall the earlier cases of O'Leary and Christianson and above all
      those of Wong. The case reported is the first in a child.

PMID- 1015798
TI  - [Association of Kaposi's sarcoma and Hodgkin's disease].
AB  - The authors report a new case of the association Hodgkin's disease and Kaposi's
      sarcoma. A woman of North African origin and suffering from mediastinal Hodgkin's
      disease developed, after the commencement of polychemotherapy with radiotherapy,
      Kaposi's cutaneous sarcoma, typical, clinically, histologically and by electron
      microscopy. In the light of this new case, the authors review 41 cases of the
      Hodgkin-Kaposi association found in the literature and discuss the inter
      relations between Kaposi's sarcoma and diseases of the haemoreticular system, in
      particular carcinomas, immuno-depressive states (notably in association with
      renal transplants) and virus disorders (essentially herpes). It might be possible
      to incriminate in the aetiology of Kaposi's disease a carcinogenetic process of
      viral origin during a state of immuno-depression.

PMID- 1015799
TI  - [Hla genotype and familial psoriasis].

PMID- 1015800
TI  - [The biochemistry of psoriasis. Serum copper and ceruloplasmin in psoriasis
      patients].

PMID- 1015801
TI  - [Hyperuricemia and psoriasis].

PMID- 1015802
TI  - [Considerations on the treatment of psoriasis].

PMID- 1015803
TI  - [Our therapeutic experiences with psoriasis in Morocco].

PMID- 1015804
TI  - [Allophlogisty in several psoriasis patients].

PMID- 1015805
TI  - [Gluten-free diet and psoriasis].

PMID- 1015806
TI  - [Digestive exploration of 13 psoriasis patients].

PMID- 1015807
TI  - [Long-term unfavorable effect of topical corticoids in psoriasis. Evaluation
      after the study of 400 children].

PMID- 1015808
TI  - [Expert testiminy for social security concerning thermal baths for psoriasis].

PMID- 1015809
TI  - [Psoriasis in blacks of Bamako. Therapeutic notes].

PMID- 1015810
TI  - A mapping function for human chromosomes.
AB  - The available simple mapping functions are surveyed, and a new mapping function
      that provides for positive interference within chromosome arms and no
      interference across the centromere is proposed, together with the corresponding
      formula for centromeric linkage. This new function is derived by assuming that
      all chromosome arms except the short arms of acrocentric chromosomes hav an
      obligatory chiasma, and that the remaining chiasmata are distributed at random;
      assumptions which may correspond reasonably well to reality. A method for the
      comparison of the goodness of fit of mapping functions with family data is given.
      Low levels of interference seem to be indicated, although as yet insufficient
      human data is available to allow interference to the specified. Interference has
      a considerable effect on the estimation of map distances between loci from 3
      point lod scores as is shown by the linkage group Rh, UMPK, PGM1, Amy, 1qh, Fy,
      on chromosome 1.

PMID- 1015811
TI  - Cytogenetics and infertility in man. II. Testicular histology and meiosis.
AB  - Within a group of 207 subfertile men, selected for testicular biopsy,
      histological investigations were made successfully in 194 chromosomally normal
      and 7 chromosomally abnormal individuals. Fifty-two per cent of men with a normal
      karyotype showed normal testicular histology, 31% showed a general depression of
      spermatogenesis and 8% showed deficiency in the late stages. Ten per cent had
      only Sertoli cells in the testis. The range of testicular conditions seen in the
      chromosomally abnormal men was similar to that found in the chromosomally normal.
      Meiotic studies carried out on 118 chromosomally normal individuals gave a mean
      chiasma count of 48-9 per cell. There was a positive correlation between high
      numbers of cells at diakinesis/metaphase I showing X and Y univalents and low
      numbers of cells reaching metaphase II. Meiosis was studied in 3 translocation
      heterozygotes, one 47, XYY male, one 47, XY+mar individual and one patient with a
      ring Y chromosome.

PMID- 1015812
TI  - The testing of dominants for heterozygoisty.
AB  - A simple method of estimating the frequency of heterozygotes among the dominants
      by test-making has been described; and then a maximum likelihood estimate is
      obtained by an iterative counting procedure. Eearly results of Haldane have been
      review and modified. Methods of estimating the gene frequencies, their ratio, and
      the inbreeding coefficient from test-mating results have also been given.

PMID- 1015813
TI  - Estimating distances from the centromere by means of benign ovarian teratomas in
      man.
AB  - Under the assumption that benign ovarian teratomas in man arise parthenogenically
      from a germ cell by suppression of the second meiotic division, the distance of a
      gene from its centromere can be estimated from the observed proportion of
      heterozygous teratomas collected from heterozygous hosts. The frequency of
      heterozygous teratomas of heterozygous hosts is equivalent to the frequency of
      second division segregation at the gene locus which has been used for centromere
      related mapping in fungal genetics for more than 40 years. Mapping functions
      useful for teratoma-based mapping in man are presented.

PMID- 1015814
TI  - A restriction on the space of genetic relationships.
AB  - It was pointed out by Trustrum (1961) that even for non-inbred pairs of relatives
      it is possible for all four cross-parental kinship coefficients to be non-zero,
      and hence that the expression often assumed for the correlation between such
      relatives is not completely general. Van Aarde (1975) has recently made the same
      comment. We derive a restriction on the space of attainable Cotterman
      coefficients for a relationship between two arbitrary non-inbred relatives. This
      restriction implies that the form of the expression for the correlation is in
      fact general, although the components cannot always be interpreted as parental
      kinships.

PMID- 1015815
TI  - The secondary sex ratio in the United States 1969-71: association with race,
      parental ages, birth order, paternal education and legitimacy.
AB  - The simultaneous effects of several variables on the secondary sex ratio have
      been examined using data from over 5,000,000 births which occurred in the United
      States during 1969-71. The previously described negative association of birth
      order and sex ratio has been confirmed. For legitimate and illegitimate births
      combined, maternal age and paternal age are unimportant factors once account is
      made of birth order. This pattern obtains for both blacks and whites. The sex
      ratio for legitimate and illegitimate births is equivalent but the fact of
      legitimacy or illegitimacy may affect the association of the ratio with birth
      order and the parental ages. Paternal education is not significantly related to
      the ratio, but the highest probability of a male birth is found among fathers
      with intermediate levels of attainment. Even though the association between sex
      ratio and order of birth is highly significant in the statistical sense, the
      proportion of male births changes less than 2% over the extreme values of birth
      order. Furthermore, it is emphasized that the association accounts for only a
      very minor (less than 10%) proportion of the total variation in the ratio.

PMID- 1015816
TI  - Two-sided assortative mating for a single locus.
AB  - Most models previously considered for assortative mating were such that no change
      in gene frequencies occurred, or that one-sided assortative mating was occurring.
      Two-sided assortative mating is more realistic for human populations, and in this
      paper a model of two-sided assortative mating is analysed for two autosomal
      alleles with dominance, an important case for human genetics. The concept of a
      relative probability of matin between two phenotypes is used, and this variable
      can take into account factors such as different propensities for assortment in
      the various phenotypes and so forth. It is shown that the gene frequency may vary
      from generation to generation and conditions for the establishment of a stable
      polymorphism are given. For instance, Stanton (1947) has considered a special
      case of two-sided assortative mating with two autosomal alleles and a constant
      correlation between mates, where the value expressed by the heterozygote is
      numerically exactly half-way between the values exhibited by the two homozygotes.
      Also he has considered a special form of assortative mating, where the
      probability of occurrence of matings between the same homozygotes has been
      increased in each generation by the same constant factor as the probability of
      occurrence of matings between different homozygotes has been decreased. The
      probability of occurrence of matings involving heterozygotes remains the same as
      if mating were random. For this particular model the frequency of the genotypes
      in those who mate in generation t is the same as for the general population in
      generation t, but the genotypic frequencies change from generation to generation,
      reaching an equilibrium value. Stark (1976) has also considered a similar model
      to Stanton's (1947), the major difference occurring in the construction of the
      mating frequencies, which in this case occurs according to the canonical
      decomposition of the 2-way table of mating frequencies. Stark shows the
      correspondence between the results for this model and those given by Malecot
      (1939, 1948). The results for all these models depend on the particular values
      assigned to the genotypes. Also these models could be extended as outlined in
      this article for the case of two autosomal alleles with dominance.

PMID- 1015817
TI  - Limits of the general two-allele single locus model with incomplete penetrance.
AB  - A graphical method is presented that allows an investigator to find the
      mathematical limits of the general one locus two allele genetic model for any
      trait whose population prevalence is known. It is seen that while the model is
      quite flexible in its ability to fit family data, there remains a large area
      where the model cannot be fitted. Specific sub-regions corresponding to
      particular hypotheses (e.g. underdominant v. intermediate v. overdominant) can be
      found, thereby limiting the area that needs to be searched by other more
      complicated techniques. Moreover, knowledge of where a set of observations lies
      can enable an investigator to frame and test specific subhypotheses.

PMID- 1015818
TI  - Asymptotic behaviour of the mean of a phenotypic diffusion process.
AB  - Asymptotic genotypic frequencies are evaluated as functions of selection
      parameters and initial conditions of a phenotypic diffusion process. On the basis
      of asymptotic relations between genotypic frequencies some analytic results about
      equilibrium are obtained.

PMID- 1015819
TI  - The fitness of human translocation carriers.
AB  - A simple method to estimate the mean fitness of human translocation carriers is
      described. The method is based on information about the inheritance pattern of
      the translocations. This kind of data can be obtained from the surveys of the
      chromosome constitutions of new-born babies. The following fitness estimates are
      obtained: D/D translocation carriers, 0-94; D/G translocation carriers, 0-83; and
      reciprocal translocation carriers, 0-67. The estimates are rather uncertain due
      to the scarcity of information, but they are consistent with the expected
      results. More accurate estimates will be obtained in the future when more data on
      translocation carriers are available and the cytological classification of the
      different translocations becomes more exact.

PMID- 1015820
TI  - [Perception of movement in depth in infants].

PMID- 1015821
TI  - [Genetic study of semiotic activities in infants from 2 years 6 months to 5-years
      of age. II.--Traces left by an activity].

PMID- 1015822
TI  - [Genetic study of temporal integration of letters into words accessibility and
      deferred responses].

PMID- 1015823
TI  - [Pollution of surface waters: Belgian regulation and microbiologic profile of the
      Sambre].

PMID- 1015824
TI  - [Medico-legal consequences of the practice of hypnosis].

PMID- 1015825
TI  - Effects of hormones and of ethanol on the fructose 6-P-fructose 1,6-P2 futile
      cycle during gluconeogenesis in the liver.

PMID- 1015826
TI  - Acyl coenzyme A dehydrogenases and electron-transferring flavoprotein from beef
      hart mitochondria.

PMID- 1015827
TI  - Studies on histidine-rich polypeptides from human parotid saliva.

PMID- 1015828
TI  - Equilibrium centrifugation of proteins in acid solutions. Ovalbumin in aqueous
      acetic, propionic, and butyric acids.

PMID- 1015829
TI  - Formation of deoxycytidine diphosphate-diglyceride by nuclei isolated from HeLa
      cells.

PMID- 1015830
TI  - Studies on the mode of sugar-phosphate product inhibition of brain hexokinase.

PMID- 1015831
TI  - Progesterone induction of lysozyme and peptidase activities in the porcine
      uterus.

PMID- 1015832
TI  - Creatine amidinohydrolase of Pseudomonas putida: crystallization and some
      properties.

PMID- 1015833
TI  - Metabolism of polyadenylic acid sequences during germination of blastocladiella
      emersoni: Zoospores.

PMID- 1015834
TI  - Multiple forms of rat liver mitochondrial DNA polymerase.

PMID- 1015835
TI  - Clearance of lysosomal hydrolases following intravenous infusion. Kinetic and
      competition experiments with beta-glucuronidase and N-acetyl-beta-D
      glucosaminidase.

PMID- 1015836
TI  - Synthesis of 24S and 24R-hydroxy-[24-3H]vitamin D3 and their metabolism in
      rachitic rats.

PMID- 1015837
TI  - Hepatic heme metabolism in selenium-deficient rats: effect of phenobarbital.

PMID- 1015838
TI  - Incorporation of (3H) leucine into the nucleoli of previtellogenic and early
      vitellogenic oocytes of Xenopus laevis: a high resolution autoradiographic study.

PMID- 1015839
TI  - [Ultrastructure of neurosecretory cells of a ganglion of the ventral nervous
      chain of Eisenia foetida (Sav.) (Annelida-Oligochgeta)].

PMID- 1015840
TI  - [Fine structure of pseudogills in teleosts].

PMID- 1015841
TI  - [Effect of lithium on the embryo of Eisenia foetida (Lombricien)].

PMID- 1015842
TI  - Influence of trypsin and concanavalin A on sponge cell aggregation.

PMID- 1015843
TI  - Exercise-induced bronchocontriction, skin sensitivity, and serum IgE in children
      with eczema.
AB  - Forty-two children with eczema were studied for exercise-induced asthma (EIA),
      skin sensitivity to prick testing, blood eosinophil count, and immunoglobulins.
      29 had a fall in peak expiratory flow rate after exercise greater than 20% and of
      these, 23 had symptoms of wheezing. 13 of the eczematous children showed a fall
      of less than 20%. The children with EIA showed greater cutaneous sensitivity (p
      less than 0.001) and a higher total serum IgE (p less than 0.025). 3 of the group
      with a fall of less than 20% had allergic rhinitis with skin sensitivity to grass
      pollen. The remaining 10 had no clinical evidence of allergic disease, other than
      eczema and skin sensitivity, and total IgE fell within the normal range. It is
      suggested that in a proportion of chilren with eczema there is little evidence of
      reaginic allergy.

PMID- 1015844
TI  - Investigation and management of long-standing chronic constipation in childhood.
AB  - The anorectal physiology of 106 children with long-standing chronic constipation,
      who had failed to response to a trial of medical treatment, was assessed. 10 (9%)
      were shown to have ultrashort-segment Hischsprung's disease, later confirmed on
      histology, The remainder showed evidence of hypertrophy of the internal sphicter
      on anorectal manometry and had a vigorous anal dilatation (to accept 4 fingers)
      under general anesthesia. After this, 38% were able to be weaned off all
      medication and most of the remainder improved. Further anal dilatation and
      internal sphincterotomy allowed a further 10 children to stop laxative, bringing
      the total to 48%.

PMID- 1015845
TI  - Maternal diabetes mellitus and congenital malformation. Survey of 205 cases.
AB  - Twenty-five out of 205 (i.e. 12%) babies born to diabetic mothers in the
      Birmingham Maternity Hospital in the period 1969-1974 were malformed as against
      6% in a control group. The incidence was highest in the group where mothers were
      on insulin at the time of conception (17 out of 117, i.e. 15%). No correlation
      was observed between major malformation in this group and age of onset or
      duration of the diabetes, progressive vascular complications, maternal age, or
      parity. Cardiovascular malformations were over-represented.

PMID- 1015846
TI  - Clinical and subclinical vitamin D deficiency in Bradford children.
AB  - A survey of the vitamin D status of Bradford schoolchildren was carried out in
      April 1973, employing conventional biochemistry, radiology, and measurement of 25
      hydroxycholecalciferol levels. Biochemical evidence of rickets was present in 45%
      of the Asians. When re-examined in September, several children showed spontaneous
      biochemical resolution; nevertheless, radiological abnormalities were present in
      12% of the original sample. No evidence of rickets was detected in the smaller
      White sample. Minor biochemical abnormalities were present in 9 of the 40 West
      Indian children. A study of admissions of Bradford hospitals in the 4 years 1969
      1972 inclusive confirmed that clinical vitamin D deficiency was confined to
      Asians except for a few cases of infantile rickets in White children. The
      probability that one Asian child in 40 may require admission during the period
      from birth to adolescence emphasizes the urgent need for the introduction of
      prophylactic measures.

PMID- 1015847
TI  - Vitamin deficiencies and neural tube defects.
AB  - Serum folate, red cell folate, white blood cell vitamin C, riboflavin saturation
      index, and serum vitamin A were determined during the first trimester of
      pregnancy in over 900 cases. For each of these there was a social classes I + II
      showed the highest levels which differed significantly from other classes, except
      for serum folate. In 6 mothers who gave birth to infants with neural tube
      defects, first trimester serum folate, red cell folate, white blood cell vitamin
      C, and riboflavin values were lower than in controls. In spite of small numbers
      the differences were significant for red cell folate (P less than 0-001) and
      white blood cell vitamin C (P less than 0-05). These findings are compatible with
      the hypothesis that nutritional deficiencies are significant in the causation of
      congenital defects of the neural tube in man.

PMID- 1015848
TI  - Analysis of 100 children with severe and persistent hypertension.
AB  - In 100 children with persistent hypertension seen over the past 5 1/2 years the
      commonest causes of hypertension were chronic glomerulonephritis, reflux
      nephropathy, coarctation of the aorta, and obstructive uropathy, accounting for
      some 70% of cases. 17 children have died, but in the remainder hypertension has
      been controlled by surgery, chronic haemodialysis, or by the use of
      pharmacological agents. Methyldopa was the commonest drug used, and the children
      appeared relatively resistant to the side effects of this and of other drugs,
      even when large doses were used. The improvment is the prognosis of severe
      hypertension in childhood indicated in this survey is largely due to the
      availability of chronic haemodialysis and transplantation for end-stage renal
      disease, but the advances in diagnositc methods and surgical techniques and the
      introduction of new drugs have also contributed.

PMID- 1015849
TI  - Measurements of muscle strength and performance in children with normal and
      diseased muscle.
AB  - A study has been made of two simple means of measuring muscle power in children
      with normal and diseased muscle. In one the length of time that the leg and the
      head could be held at 45 degrees above the horizontal was measured with the child
      supine. In the second, measurements were made of the isometric strength of six
      muscle groups with the newly developed Hammersmith Myometer. In the timed
      performance tests only 5 (8%) of a group of 61 children known to have muscle
      disease achieved the minimum expected values for their ages. Myometer readings of
      the isometric power of the children with muscle disease also have values which
      were below those of a comparable group of normal children. The reproducibility of
      muscle strength measurements in young children has been shown to be good, whereas
      the timed performance tests, though able to differentiate normal children from
      children with muscle disease, did not show sufficient reporducibility for this
      test to be recommended for sequential measurements.

PMID- 1015850
TI  - Quantitative morphological studies of developing human cerebellar cortex in
      various disease states.
AB  - A quantitative morphological assessment was carried out of the cellularity and
      staining properties of the cells of the layers of the human cerebellar cortex,
      both in the normal child and in 41 children suffering from a series of disorders
      including mental retardation. A computerized image analyser and highly
      standardized procedures were used. All of the cases of mental retardation and
      some cases with congenital cardiac anomalies showed abnormal cell concentrations
      and staining properties. 3 cases of 'cot death' also showed abnormal results.
      These findings are presented as a new measurable aspect of brain disease, and as
      a indication for further study.

PMID- 1015851
TI  - Motor nerve conduction velocity in spinal muscular atrophy of childhood.
AB  - The ulnar and posterior tibial conduction velocities were measured in 29 children
      with spinal muscular atrophy, 14 of whom had the servere form of the disease. The
      ulnar nerve velocity was slow in 12 of the 14 severely affected infants, but
      normal or fast in 11 of 14 children less severely affected. The corresponding
      results for the posterior tibial nerve were slow velocities in 11 of 12 infants
      in the severe group and normal or fast in all 11 infants less severely affected.
      The difficulty in distinguishing infantile spinal muscular atrophy from
      peripheral neuropathy is emphasized.

PMID- 1015852
TI  - Failure to thrive and death in early infancy associated with raised urinary
      homovanillic and vanillylmandelic acids.
AB  - A case of failure to thrive in an infant with persistently raised urinary levels
      of homovanillic and vanillylmandelic acids is descirbed. No neural crest tumour
      was discovered at surgical exploration or at necropsy. The relation of this
      biochemical abnormality and failure to thrive is unclear.

PMID- 1015853
TI  - Childhood actinomycosis. Report of 3 recent cases.
AB  - Three cases of childhood actinomycosis are reported, 2 with the commonest
      presentation of cervicofacial abscess and the third with a rarely reported
      superficial chest wall abscess. The importance of prompt bacteriological
      diagnosis and adequate treatment with surgical drainage and chemotherapy is
      stressed. Though in adults males are affected more frequently than females, the
      sexes are probably equally affected in childhood.

PMID- 1015855
TI  - Rapid assessment of gestational age at birth.

PMID- 1015854
TI  - Duchenne muscular dystrophy: early diagnosis, and screening.

PMID- 1015856
TI  - Treatment of hereditary hypophosphataemic rickets.

PMID- 1015857
TI  - Nutritional deprivation during protracted diarrhoea after acute gastroenteritis.

PMID- 1015858
TI  - Criteria for diagnosis of temporary gluten intolerance.

PMID- 1015859
TI  - Does conjugated bilirubin displace unconjugated bilirubin from albumin.

PMID- 1015860
TI  - Measurement and prediction of the disappearance rates from soil of 6
      chloropicolinic acid.
AB  - 6-Chloropicolinic acid is the sole detectable metabolite, other than carbon
      dioxide, arising from decomposition of 2-chloro-6-(trichloromethyl) pyridine in
      soil. The pyridine compound is a potent inhibitor of nitrification now in use
      with ammonium fertilizers. The purpose of this study was to evaluate the relative
      influence of various soil and climatic factors on rates of degradation of 6
      chloropicolinic acid in soil. Experiments with a wide range of soil types (23
      soils) demonstrate that the most important factor influencing the decomposition
      rate of 6-chloropicolinic acid is soil temperature. When temperature is not a
      variable, the quantity of organic matter (0.9 to 6.9% by weight) and pH (4.8 to
      8.1) significantly affect the rate of decomposition, but sand, silt, and clay
      percentages do not. Moisture content was without apparent effect because the
      range of values investigated was too narrow. A fractional-order rate law (0.7)
      describes the disappearance rate best. Application of the Arrhenius equation to
      the data for the decomposition of 6-chloropicolinic acid in soil indicates an
      activation energy of 6.57 kcal per mole, suggesting that the chemical is
      biologically rather than chemically degraded. It was not possible to develop a
      suitably precise equation for prediction of loss rate as affected by the above
      soil and climatic factors because undefined biological factors in the soils
      override the effect of measurable properties of soil and climate.

PMID- 1015861
TI  - Insecticide and nutrient transport in water, related to agricultural land use of
      a stream basin in Ontario, Canada.
AB  - Transport by stream water of insecticides and nutrients in Big Creek, Norfolk
      County, Ontario, Canada, was examined by combining concentrations of substrates
      with flow data. Big Creek has its headwaters in dairy cattle country, its central
      basin area is mainly devoted to tobacco growing, and its lower reaches contain
      mixed farming, corn and vegetables, etc., before it flows into Lake Erie. Three
      sampling sites were chosen to represent these 3 different land uses. Generally
      concentrations of substrates in the water were quite uniform at the 3 sites
      resulting in transport of quantities in proportion to stream flow. Certain
      anomalies occurred and are discussed. The 2 chief insecticides found were DDT and
      dieldrin. Analyses for potassium, calcium and magnesium indicated that these
      nutrient losses into the stream were area-rather than usage-dependent. Midseason
      variations in loss of nitrogen and phosphorus may be the result of agricultural
      practices in the three areas represented in this study. The largest quantities of
      all nutrients lost occurred early in the season before crops were established.

PMID- 1015862
TI  - Toxic, neurochemical and behavioral effects of dieldrin exposure in mallard
      ducks.
AB  - Toxic, neurochemical and behavioral alterations were evaluated in ducks fed
      various dietary levels of dieldrin. Increasing amounts of dieldrin in the diet
      caused an appreciable decrease in the levels of three biogenic amines in whole
      brain, i.e. serotonin, norepinephrine and dopamine. No effect was noted in whole
      brain gamma aminobutyric acid contents. Hepatic microsomal enzymes were assayed
      in these birds using p-nitroanisol and O-ethyl-O-p-nitrophenyl
      benzenethionophosphate as substrates. Sublethal amounts of dieldrin caused an
      increase in hepatic drug metabolizing enzymes. Similar alterations were noted in
      liver protein, deoxyribonucleic acid and ribonucleic acid contents. Studies
      involving encounters between mallard drakes indicated a decline in the tendency
      for dieldrin exposed drakes to take the initiative and establish rights of access
      in approach confrontations. Although many of these changes are compatible with
      life processes, their significance is not well understood, especially in terms of
      lifelong exposure to persistent pesticides. The possible relationship between
      neurochemical alterations and the mechanisms of insecticide neurotoxicity is
      discussed.

PMID- 1015863
TI  - Disappearance of dislodgable residues of five organophosphate pesticides on
      citrus leaves and fruit during dry and wet weather in Florida.
AB  - Citrus leaf discs and fruit taken from trees sprayed at recommended levels and
      twice recommended levels with ethion, parathion, azinphosmethyl, carbophenothion,
      and dioxathion were shaken with water and wetting agent for removal of
      dislodgable residues at 0, 1, 3, 5, 7, 14 and 21 days following treatment. The
      first portion of the field experiment was performed during a period of no
      rainfall (April) and the second when there was rainfall (July) in 1973. Four
      replicates of 50 leaf discs and 4 fruit, respectively, were averaged from each
      sampling to give data reported. A gas chromatograph equipped with a flame
      photometric detector was used for analysis. Dislodgable residues found decreased
      with increasing time following application and samples from the wet period were
      lower than those from the dry period. Moisture and temperature could account for
      the differences in the two sampling period.

PMID- 1015864
TI  - Alteration of O,O-dimethyl S-[alpha-(carboethoxy)benzyl] phosphorodithioate
      (phenthoate) in citrus, water, and upon exposure to air and sunlight.
AB  - The fate of 32P- and 14C-labeled O,O-dimethyl S-[alpha-(carboethoxy)benzyl]
      phosphorodithioate (phenthoate) was determined in citrus, water, and upon
      exposure to air and sunlight. The products recovered from citrus and glass plates
      exposed to sunlight were unchanged phenthoate, phenthoate oxon, demethyl
      phenthoate, mandelic acid, bis-[alpha-(carboethoxy)benzyl] disulfide, O,O
      dimethyl phosphorothioic and phosphorodithioic acid. Similar products generally
      were found in citrus leaf and fruit extracts. Phenthoate was fairly stable in
      phosphate buffered water with a half-life of approximately 12 days at pH 8.0. The
      major hydrolysis products were phenthoate acid, demethyl phenthoate and demethyl
      phenthoate oxon.

PMID- 1015865
TI  - [Statistical research into the diagnostic methodology in bacterial infections of
      the respiratory system as at present practised by various centres (author's
      transl)].
AB  - A research program has been carried out using a questionnaire to survey
      statistically the diagnostic methods obtaining in the bacteriological examination
      of sputum. Of the 336 forms sent to: 1. all the regional, 2. most of the
      provincial, 3. some local, hospital laboratories, only 48 were returned. From
      these limited numbers we have extracted the data discussed in the present paper.

PMID- 1015866
TI  - [Microbiological and cytological aspects of the aspirate bronchoscopy (author's
      transl)].
AB  - The Authors compare by microbiological and cytological aspect the result got by
      sputum and aspirate at bronchoscopy. They point out that aspirate at bronchoscopy
      permits a more significant etiological diagnosis by both microbiological or
      cytological point of view.

PMID- 1015867
TI  - [Sensitivity tests on bacterial strains from respiratory tract: comparison
      between direct and on isolated strains antimicrobial disc susceptibility test
      (author's transl)].
AB  - The validity of the direct antimicrobial disc susceptibility test has been
      compared with the same test carried out on bacterial strains isolated from
      clinical materials obtained from the respiratory tract. The experimental evidence
      so far obtained raises some doubts concerning the reiliability of the direct
      test. The use of the latter seems to be reccomended in urgent cases only
      considering that either with multimicrobic or monomicrobic material the results
      obtained are partial and slightly reproducible. The conclusion is that, in order
      to obtain an accurate picture of the sensitivity to the various antibiotics, the
      direct test should be followed always with the antimicrobial disc susceptibility
      test carried out with isolated strains.

PMID- 1015868
TI  - [Anaerobic flora of the respiratory tract (author's transl)].
AB  - The general outlines for the microbiological study of respiratory tract anaerobic
      flora are indicated. To day research tend to assign to these bacteria a
      significant role in sustaining some diseases of lungs pleural space and upper
      respiratory tract; anaerobes are therefore a subject of outstanding interest for
      clinical microbiologists. Difficult arise in isolation and identification of
      respiratory tract anaerobes owing to normal presence of anaerobic flora in the
      mouth; the difficult can be overcomed by avoiding contamination with normal flora
      (lung puncture for instance) or by quantitative evaluations of bacteria in
      sputum.

PMID- 1015869
TI  - [Significance of mycoplasma species in the respiratory tract (author's transl)].
AB  - After consideration of the tassonomic and biological characteristics of
      Mycoplasma species, the Author discusses the most significant aspects on M.
      pneumoniae infections. On the basis of: natural history of respiratory
      infections; epidemiology; experimental aspects of M. pneumoniae infection;
      immunology; microbiological and serological diagnosis.

PMID- 1015870
TI  - [Mycobacterial infections in man: bacteriological, clinical and epidemiological
      evaluation (author's transl)].
AB  - At present time the direct microscopy of acid-alcohol fast bacteria includes
      Mycobacteria, Nocardia, "rhodochrous complex". Direct microscopy is suitable to
      identify visible and not viable bacteria, the debacillization curve and the fall
      and rise phenomenon. Strains of M. tuberculosis complex are frequently with
      partial virulence low infectivity, and are modified by drugs. Little or no
      reaction to PPD is present.

PMID- 1015871
TI  - [Contributions to the interpretation of the immunoglobulins's variations in the
      bronchial secretions (author's transl)].
AB  - Study of the relationships between the variations of the connections between the
      components of the bronchial secretion and the viscosity of the sputum, with
      particular regard to the role of the IgA IIS and to the secretory piece.

PMID- 1015872
TI  - [The secretory IgA. The local secretory immunitary system (author's transl)].
AB  - The Authors take into examine the local secretory immunitary system (L.S.I.S.)
      starting from the presence of antibody-molecules in secretions: they study
      origin, characteristics, action and excitement procedures of this class of
      molecules, also compared with the immunitary central system.

PMID- 1015873
TI  - [Bidimensional I.E.F. of proteins in the bronchial secretion (author's transl)].
AB  - Qualitative and quantitative determination of the proteins in the bronchial
      secretions (of about 50 patients suffering from chronic bronchitis) after
      extraction.

PMID- 1015874
TI  - [IgE levels in children affected by respiratory allergies (author's transl)].
AB  - Radioimmunological technique has been used in order to measure IgE seric levels
      on 100 children affected by respiratory allergies, on 46 children with non
      allergic respiratory diseases and on 54 healthy children distributed in different
      classes of age. In the 58% of cases, allergic subjects presented IgE levels
      remarkably increased compared with non allergic ones, in the 28% of cases IgE
      levels had an insignificant increase, and in the remaining 14% the values were
      comparable with those of the non allergic subjects.

PMID- 1015875
TI  - [1st cases of histoplasmosis caused by Histoplasma capsulatum in Rwanda].

PMID- 1015876
TI  - [Salmonella isangi. Its role in the epidemiology of human Salmonella infections
      in Kinshasa from 1969-1973].

PMID- 1015877
TI  - [Endemic bladder calculi in children in Rwanda].

PMID- 1015878
TI  - [Lithogenic elements in the rural diet of Rwanda].

PMID- 1015879
TI  - Cysticercosis of pigs in the Republic of Zaire and its relation to human
      taeniasis.

PMID- 1015880
TI  - The effect of normal human serum on trypanosomes of distinct antigenic type (ETat
      1 to 12) isolated from a strain of Trypanosoma brucei rhodesiense.

PMID- 1015881
TI  - [Isolation and distribution of Nocardiae in the Bas-Zaire].

PMID- 1015882
TI  - [Study of the symptomatology of African trypanosomiasis in children (apropos of
      24 cases)].

PMID- 1015883
TI  - [Infestation by Onchocerca volvulus in the Lusambo region (East Kasai, Zaire),
      Parasitological, ophthalmological and immunologic aspects].

PMID- 1015884
TI  - [Study of an epidemiologic model applied to malaria].

PMID- 1015885
TI  - Frequencies of the polymorphic types of red cell acid phosphatase in Zairians and
      in Belgians. Relation between phenotypes and enzymatic activities.

PMID- 1015886
TI  - Recurrent hyperparathyroidism.
AB  - Recurrent hyperparathyroidism occurred in 11 of 295 patients from 10 months to 34
      years after an initially successful operation. Seven patients with recurrent
      hyperparathyroidism had either multiple endocrine adenomatosis type I (MEA) or
      familial hyperparathyroidism (FHP), one patient had parathyroid cancer, and two
      patients had renal failure at the time of recurrence. Four of these patients ahd
      their initial operations elsewhere. Recurrence developed in 33% of patients with
      MEA or FHP but in only 0.4% of 242 patients without MEA or FHP. The presence of
      MEA or FHP was known before parathyroid exploration in 18 (86%) of the 21
      patients. In patients with MEA or FHP, subtotal parathyroidectomy should be
      performed if there is more than one gland involved. Other patients should be
      treated by selective removal of an adenoma because recurrence is rare. Subtotal
      parathyroidectomy should be reserved for patients with diffuse hyperplasia.

PMID- 1015887
TI  - Pancreatectomy for chronic pancreatitis.
AB  - Of one hundred and forty-nine patients (101 male and 48 female) 4-67 years of
      age, 117 were alcoholics and underwent pancreatectomy because of episodic or
      continuous abdominal pain or complications or chronic pancreatitis. Nineteen
      patients underwent pancreaticoduodenectomy, seventy-seven 80-95% distal
      resection, anf fifty-three 40-80% distal pancreatic resection. There were 3
      operative death and 30 late deaths 6 months to 11 years post pancreatectomy.
      Twenty-one patients were lost to followup, 1 to 11 years post pancreatectomy.
      Ninety-five patients are known to be alive, 4 of whom are institutionalized.
      Indications for pancreatectomy in addition to abdominal pain include recurrent or
      multiple pseudocysts, failure to relieve pain after decompression of a
      pseudocyst, pseudoaneurysm of the visceral arteries associated with a pseudocyst,
      recurrent attacks of pancreatitis unrelived by non-resective operations, duodenal
      stenosis and left side portal hypertension. The choice between
      pancreaticoduodenectomy or distal resection of 40-80% or 80-95% of the pancreas
      should be based on the principle site of inflammation whether proximal or distal
      in the gland, the size of the common bile duct, the ability to rule out
      carcinoma, and the anticipated deficits in exocrine and endocrine function. The
      risk of diabetes is very significant after 80-95% distal resection and of
      steatorrhea after pancreaticoduodenectomy. When the disease process can be
      encompassed by 40-80% distal pancreatectomy this is the procedure of choice.

PMID- 1015888
TI  - Abnormalities in gallbladder morphology and function in patients with
      cholelithiasis.
AB  - Thirty-seven symptomatic cholelithiasis patients who had cholecystectomy were
      studied to determine the relationships between clinical manifestations,
      histologic findings and gallbladder absorptive capability. A clinical score was
      calculated from clinical data which we thought might be predictive of abnormal
      gallbladder histology. Histologic parameters indicative of gallbladder disease
      were used to calculate a histologic score. Shortcircuit current measurements,
      which reflect gallbladder sodium absorption,were used to assess absorptive
      function. Patients with very high clinical scores, indicative of pronounced
      clinical score was not predictive of histologic findings or absorptive function
      of the gallbladder is directly related to the degree of histologic abnormality,
      and that absorptive capability is not an all-or-none phenomenon. The data also
      show that visualization on oral cholecystography is an unreliable measure of
      gallbladder absorptive capability.

PMID- 1015889
TI  - Proximal gastric vagotomy: effects of two operative techniques on clinical and
      gastric secretory results.
AB  - PGV performed in 39 patients by separating the lesser omentum from the stomach
      beginning 6 or 7 cm proximal to the pylorus and skeletonizing the distal 1 to 2
      cm of esophagus was followed by 15.4% of proven and 10.2 of suspected recurrent
      ulcers. Insulin tests were done during the first 3 months postoperatively on 31
      of the patients, including the 6 with proven and the 4 with suspected recurrent
      ulcers. The peak acid output to insulin minus tha basal acid output (PAOI-BAO)
      was less than 5 mEq/hr in 16 cases (52%) and from 5 to 25 mEq/hr in the remaining
      15 cases. In 6 patients with proven recurrent ulcer, PAOI-BAO averaged 21.9
      mEq/hr (range, 11.3 to 41.8); in the 4 patients with suspected recurrence, 9.5
      (range, 4.4 to 11.8). The operative technique was changed in one respect; the
      distal 5 to 7.5 cm of the esophagus was skeletonized. In 14 patients, the mean
      PAOI-BAO +/- S.E. within 3 months of PGV was 1985 +/- 0.7 mEq/hr, and 13 of 14
      values were less than 5 mEq/hr. One patient developed recurrent ulcer and
      required re-operation; this patient's value for PAO-BAO was 1.8 mEq/hr. The
      results show quantitatively that great differences in the completeness of PGV
      result from differences in the periesophageal dissection and emphasize its
      importance if optimal results are to be obtained and, especially, if the efficacy
      of the operation is to be judged.

PMID- 1015890
TI  - The value of thymectomy in myasthenia gravis: a computer-assisted matched study.
AB  - In the absence of a prospective randomized study of patients treated
      conservatively or with thymectomy, a computer-assisted retrospective matches
      study was devised. Of 563 patients treated for myasthenia gravis without thymoma
      up to 1965, 104 had thymectomy. With computer assistance, each surgical patient
      was matched with a medical patient on the basis of age, sex, and severity and
      duration of disease. On this basis 80 of the 104 surgical patients could be
      matched satisfactorily. There were 16 males and 64 females in each of the matched
      surgically treated and medical control groups. A complete remission was
      experienced by 27 of the 78 patients in the surgical group as compared to 6 of
      the medical group. Improvement was noted by 26 of 78 surgically treated patients
      and 13 of 78 receiving medical treatment. Survival for patients having
      thymectomy. Thirty-four patients in the medical group had died as compared to 11
      in the surgical group. Comparison of survival in relation to sex, duration of
      symptoms, or age (less than 30 or less than 30 years) did not show a significant
      difference. Until more effective treatment is available for myasthenia gravis,
      thymectomy deserves consideration for both sexes, and with increased age or long
      duration of symptoms.

PMID- 1015891
TI  - Prognosis of gastric ulcer: twenty-five year followup.
AB  - Four hundred twenty-two patients with gastric ulcer treated during 1950-1960 were
      followed up to 25 years with a mean followup of 9 years. Nonoperative treatment
      was used in 59% with a hospital mortality of 35%, one-third of these deaths being
      directly due to gastric ulcer perforation or hemorrhage. Operative treatment was
      used in 41% of patients. The most common operation (86%) was gastric resection
      without vagotomy. Overall operative mortality was 16%; 34% for emergency
      procedures and 6% for elective procedures. Cachexia seemed to be the most
      important factor related to operative mortality. Nonoperative treatment resulted
      in more than twice the hospital mortality compared to operative treatment.
      Approximately one-half of all patients treated non-operatively had a recurrent
      gastric ulcer at some time during this study. The recurrence rate following
      definitive gastric resection was 1.3% compared with 16% during nonoperative
      therapy. Three-fourths of recurrences occurred later than two years and nearly
      half of recurrences after more than 5 years of followup. Patients with a prior
      history of overt bleeding from gastric ulcer disease particularly were at risk
      for further bleeding. There were coincidental duodenal ulcers in 10% of our
      patients and a 0.8% incidence of gastric cancer during followup. Long term
      followup demonstrates the superiority of operative treatment of gastric ulcer and
      also reveals the continuous propensity of such ulcers to recurrence following
      nonoperative treatment. Earlier elective operation in patients with overt
      bleeding, recurrence or persisting symptoms should decrease overall mortality and
      result in a lower overall long-term risk of ulcer complications.

PMID- 1015892
TI  - Ultrasonography as an aid in the diagnosis and management of surgical diseases of
      the pelvis: special emphasis on the genitourinary system.
AB  - Technological advances, particularly the advent of the gray scale technique, has
      greatly extended the application and usefulness of this modality to clinical
      diagnoses and surgery. The ultrasonic beam uniquely provides anatomical profiles
      in the transverse (cross-sectional) and sagittal (longitudinal) planes of the
      body. Intra-rectal and intra-vaginal ultrasonic probes have provided unique
      definition of both the normal and pathologic anatomy of the pelvic organs. The
      present report is drawn from a continuing experience with ultrasonography of the
      genitourinary system with an update of current technological advances.
      Ultrasonography has proven especially valuable in the following clinical
      applications: 1) Early diagnosis of cancer (especially of the prostate); 2)
      Accurate staging of cancer of the bladder and prostate; 3) Monitoring of the
      response of the pathologic process to therapy.

PMID- 1015893
TI  - Parotid neoplasms: a report of 250 cases and review of the literature.
AB  - A 25-year experience with parotid tumors was reviewed. From a total of 250
      neoplasms, 173 were histologically benign and 77 were malignant. Benign mixed
      tumors accounted for 59% of all lesions. Clinical parameters used to diagnose
      parotid neoplasms were found to be unreliable in determining whether a given
      tumor was benign or malignant. The mean age for malignant lesions was 10 years
      greater than for benign lesions. The phenomenon of malignant transformation of a
      benign tumor was considered in four patients. Complete surgical excision is the
      safest and preferred method for diagnosis. Preoperative needle or incisional
      biopsy are associated with a high degree of local recurrence. The appropriate
      management of any parotid tumor is predicated on special histological type. Local
      excision or enucleation no longer have a place in the surgical management of
      benign parotid tumors. Postoperative tumor recurrence and morbidity are directly
      related to awareness of surgical anatomy and pursuit of correct surgical
      techniques for adequate resection. The five-year recurrence rate for 102 benign
      mixed tumors was 6%. Recurrence in malignant tumors varied with specific
      histological types but was generally high. Five-year survival for all malignant
      parotid tumors was 48%.

PMID- 1015894
TI  - Comparison of Payne and Scott operations for morbid obesity.
AB  - One hundred five patients were operated upon for morbid obesity using accepted
      criteria for operation. Forty-five patients with the Payne operation (35 cm of
      jejunum anastomosed end-to-side to 10 cm of ileum) were compared with 45 patients
      having the Scott operation (30 cm of jejunum anatomosed end-to-end to 15 cm of
      ileum with the proximal cut end of ileum vented into the transverse colon). The
      weight loss in the first two years was similar, although the Scott procedure
      patients lost slightly more weight. Comparison of the two groups by a new grading
      system also showed little difference in the two procedures. The Scott procedure
      takes longer and subjects the patient to an additional anastomosis. Study of a
      smaller group of patients having the Scott operation with varying lengths of
      jejunum and ileum indicates that there should not be less than 30 cm of jejunum
      nor more than 15 cm of ileum left in continuity. The length of jejunum is
      particularly important in the production of weight loss, and accurate
      intraoperative measurement of intestinal length is crucial. In the postoperative
      period the length of functional jejunum and ileum can be determined by upper
      gastrointestinal barium roentgenograms.

PMID- 1015895
TI  - [Cardiac prosthesis].

PMID- 1015896
TI  - [Comparative study of the most frequently used clinical methods for the analysis
      of immunoglobulins].
AB  - Methods for the quantitation of seric immunoglobulins are compared in this work:
      euglobulins by the Sia methods vs. IgM by radial immunodiffusion, and
      gammaglobulins with the zinc reactive vs. IgG by radial immunodiffusion. The
      results of the analysis of 81 sera of patients from the National Institute of
      Cardiology indicates that the values obtained with the methods for euglobulins
      and gammaglobulins are comparable to those obtained for IgM and IgG by radial
      immunodifussion.

PMID- 1015897
TI  - [Molecular mechanism of noradrenaline transport by rat auricles in vitro].
AB  - The transport of tritium-labelled noradrenaline (3H-NA) into bisected rat
      auricular appendages in vitro, has been studied, using 14C-inulin as an
      extracellular space tracer, thus allowing a precise measurement of the 3H-NA
      transported into the cells. The NA transport time course is relatively fast, and
      initial rates lasted 5 min. in 150 mM sodium, 3 min. in 26 mM sodium, and about 1
      min. in 50 mM potassium. Intracellular accumulation of 3H-NA by synaptic
      vesicles, was found not to be important in the first minute of transport. In the
      presence of 150 mM sodium a transport Km for NA of 0.59 +/- 0.06 muM (mean +/-
      S.E.M.) and a maximal velocity (Vmax.) of 2.44 +/- 0.43 pmol/mg. protein/min.
      were estimated. When sodium was lowered to 26 mM, the Km increased to 2.26 +/-
      0.7 muM (P less than 0.001), while Vmax. showed no change. With 0 mM sodium
      (choline substitution) active NA transport is completely suppressed, and only a
      diffusional component can be discerned. No binding of NA to beta adrenergic
      receptors was found, and a small but highly significant binding to the non
      specific catechol receptors could be detected.

PMID- 1015898
TI  - [Single ventricle. II. Clinical study. Special studies and surgical treatment].
AB  - A study was made of 29 cases of single ventricle confirmed by autopsy,
      hemodynamic study, or both. It must be emphasized that the term single ventricle
      excludes whatever malformation which shows traces of an intraventricular septum.
      Thus conceived, the malformation has been seen to have different clinical
      courses, which only permit partial diagnosis that may suggest the possibility of
      "single ventricle". In live patients this can only be diagnosed with specialized
      studies. In outline, there exist 4 types of clinical hemodynamic behavior: 1) The
      type with marked increase of pulmonary flow, in which the single cavity vascular
      systems, pulmonary and aortic, had similar pressures. This type behaves, in a
      certain way, like large interventricular communications. 2) The type which
      behaves hemodynamically like a large hypertensive communication with delayed
      cyanosis of rapid evolution and with few manifestations of heart failure. 3) The
      third type also has pulmonary hypertension with delayed cyanosis. This differs
      from the preceeding in that there is a preferential flow in such a way that the
      venous blood proceeding from the right atrium empties into the aorta and the
      arterial blood from the left atrium empties into the pulmonary artery. 4) The
      fourth type is characterized by rapid cyanosis and from the anatomical point of
      view has stenosis or atresia of the pulmonary artery. An analysis was made of the
      varieties which within these four classes actually ocurred or cases which were
      present as theoretical possibilities: single ventricle with crossed great
      arteries; single ventricle with transposition of the great arteries; single
      ventricle with partial distortion of the great arteries; single ventricle with
      common trunc. A detailed analysis was made of the clinical, hemodynamic,
      electrocardiographic, and radiological manifestations which are seen in these
      combinations and an anatomic-embriologic classification is proposed on the basis
      of the systematization of the 29 cases of the present study. Finally brief
      considerations are made of the operability of those cases of single ventricle
      according to their anatomic variety.

PMID- 1015899
TI  - [Diagnostic problems in visceral heterotaxia].
AB  - Due to the lack of uniformity in the criteria for formulating the diagnosis of
      the syndrome of heterotaxy, 12 cases with this abnormality were reviewed. The
      patients were selected on the following basis: symmetrical liver, changeable P
      waves in consecutive electrocardiograms, bronchial isomerism, hematological
      disturbances, anomalous relationship of the inferior vena cava and abdominal
      aorta, anomalous systemic and pulmonary venous drainage and complex cardiac
      malformations. The most frequent findings were: symmetrical liver, changeable P
      waves, anomalous systemic venous return, anomalies of the atrio-ventricular
      valves, particularly atrioventricular canal, aorto-cava juxtaposition, single
      atrium, anomalous pulmonary venous return, transposition of the great arteries
      and pulmonary stenosis. Less frequent anomalies were: atrial and ventricular
      septal defects, atrial isomerism, truncus arteriosus and partial distortion of
      the great arteries. The hematological disturbances as well as the radioisotope
      scanning of the liver and the spleen were of little help. Suggestions are given
      for the diagnosis of the syndrome and for the evaluation of present diagnostic
      procedures making necessary to use the data gathered with more precision.

PMID- 1015900
TI  - [Congenital cardiopathies in the newborn].
AB  - Ten years experience in newborn congenital cardiac malformations with severe
      hemodynamic changes is reported. The anatomic diagnosis was made at necropsy
      (85%) or by cardiac catheterization and angiocardiography (15%). One hundred and
      twenty-six cases were found in which aortic valve atresia or stenosis, tricuspid
      atresia, cardiac anomalies associated to visceral heterotaxy, tetralogy of
      Fallot, aortic coartation, endocardial cushion defect, ventricular septal defect,
      total anomalous pulmonary venous return and pulmonary atresia with intact
      ventricular septum were the most common malformations. They presented with either
      cardiac insufficiency or hypoxia and acidosis. The principal anatomic features of
      these cases were discussed and the associated malformations in other systems was
      noted.

PMID- 1015901
TI  - [Value of the indices of myocardial contraction rate in patients with chronic
      mitral insufficiency].
AB  - Determinations of dp/dt max, Vec and Vmax were made in 20 patients with chronic
      mitral regurgitation of several degrees. Each of these results was correlated
      with the corresponding ejection fraction. Only dp/dt max showed adequated
      correlation and few scattering of individual results, demonstrating its true
      dependence on the intrinsec contractile state of the left ventricule. Vec. and
      Vmax. determinations also reflected contractility changes, but their variability
      and difficult clinical applicability does not allow to recommend its routine
      utilization in a clinical setting. We could not demonstrate any influence of the
      valvular lesion on the results of the measured contractility indicators.

PMID- 1015902
TI  - [Electrocardiography changes in newborn infants during the 1st 6 weeks of life in
      Mexico City. Physiological implications].
AB  - The electrocardiograms of 150 newborns who were born in Mexico City (2,240 m.
      above sea level) were obtained in the first 24 hours of life and six weeks later.
      The electrocardiographic changes were similar to those observed at sea level;
      AQRS shifted to the left, the T waves became negative in the right precordial
      leads and the R/S relation increased in the left precordial leads. Mid-altitude
      does not affect the pulmonary vascular maturation of the normal newborn.

PMID- 1015903
TI  - [Diagnosis of venous thrombosis by using radioisotopes].
AB  - Thromboembolism problem is a grave complication which occurs with great frequency
      in patients hospitalized in a critical state. The association between periferical
      venous thrombosis and the thromboembolic accident is plainly demonstrated,
      although the accurate establishment of the clinical diagnosis of phlebothrombosis
      is only feasible in 50% of the cases. In the present work, we describe the
      methodology and the experience which we have acquired with the use of
      radioisotops in the diagnosis of these problems. We studied 64 patients to whom
      in the supine position we injected into a vein in both heels, from 3 to 5
      millicuries of 99m-Tecnecio, practicing three stages: dynamic venography, a
      static study, and a pulmonary gammagram. In the normal cases, we clearly
      identified the tracts of the principal femural, iliac, and the inferior third of
      the inferior vena cava veins. In the abnormal studies, we observed the
      obstructive process manifested by the absence of radioactivity in the affected
      venous tract, with appearence of collateral circulation, definitive data which
      establishes with certainty the diagnosis. It can be concluded that the method is
      rapid and easily carried out, meaning that it could be a routine practice in all
      of those patients who are suspected of having this problem.

PMID- 1015904
TI  - [Treatment of supraventricular paroxysmal tachycardia and auricular flutter by
      auricular stimulation].
AB  - Although the management of supraventricular tachycardias (SVT) and atrial flutter
      (AF1) with drugs or cardioversion is usually effective, their use in the high
      risk patient commonly digitalized, may be dangerous. Since the availability of an
      alternate therapeutic method is desirable, the usefulness of atrial pacing was
      evaluated in 31 episodes of tachyarrhythmia in 31 patients with varied heart
      conditions. The arrhythmia diagnosis and the stimulation were done through a
      right atrial electrode. In most cases the rate of stimulation was higher than
      that of the atria (up to 400 stimuli per min). Of 17 cases with SVT (four with
      preexcitation syndrome), pacing led to sinus rhythm (SR) in all, even though it
      was transient in two. SR was obtained in six of eleven cases of AF1, through a
      short lasting atrial fibrillation (AF) in three of them. Four patients with
      paroxysmal atrial tachycardia with A-V block changed to AF. SR was achieved
      shortly after termination of the procedure in two of the latter. It is concluded
      that atrial pacing is a valuable therapeutic method since it is effective, it has
      very low risk specially in digitalized patients, its does not require anesthesia
      and because it may be used repeatedly in case of recurrence. The technique of
      atrial pacing permits, in some cases, the identification of the mechanism
      responsible for the arrhythmia.

PMID- 1015905
TI  - [Hemodynamics changes in children and adolescents with mitral valve replacement].
AB  - The authors analyze the pre and post-operative hemodynamic picture of 30 children
      and adolescents with mitral valve replacement, which corresponds to a group of
      106 patients operated on from 1964 to 1974. At variable time periods, between 9
      days and 48 months (average 28 months) from the valve replacement, a new
      catheterization was done. The majority of the studies were done in the period
      between 13 and 36 months. Of the 30 cases, 21 were carriers of the Starr-Edwards
      valve, and the rest of different types. The Starr-Edwards valves produced a
      lawering of the CVP from 23.0 to 11.0 mm. Hg (average values) whereas with the
      other types the average pre-operative figure was 21.0 and in the post-operative
      period it fell to 11.0 mm. Hg. In the group with SE valves, pre-operative SPP was
      an average of 64.3 and in the post-operative period it was 32.0 mm. Hg. In the
      cases of SE valves the pre-operative total pulmonary resistances were 12.3 units
      and post-operatively they fell to 3.7 units. With the other types of valves the
      pre-opeative average was 10.9 units and post-operatively it was 5.3 units. The
      hemodynamic results obtained over a period of time with valvular substitution
      were similar in the distinct types of valves. However in the SE the benefits
      resulted more constant. The value of radiological and electrocardiographic study
      in order to predict the early post-operative hemodynamic changes is discussed.
      These studies serve essentially for a long range evaluation, whereas the
      hemodynamic, and clinical improvement maintained a strict relationship. This work
      shows that, in children and adolescents, the presence of severe venous-capillary
      and arterial pulmonary hypertension, and the elevated pulmonary resistences, are
      not contraindications for surgical treatment. It equally proves the eficacy of
      the valvular replacement, when the surgical indication and the control of the
      patients are handled in the proper way.

PMID- 1015906
TI  - Antihypertensive activity of a propranolol analog (ORF 12,592) in rodents.
AB  - Studies were carried out to determine the antihypertensive effects of the 5
      hydroxy derivative (ORF 12,592) of propranolol. Acute administration of ORF
      12,592 produced a reduction in mean systolic blood pressure in
      desoxycorticosterone acetate (DOCA) rats and in spontaneously hypertensive rats
      (SHR). Propranolol was not effective in DOCA rats and produced a significant
      blood pressure reduction in SHR 48 hr after acute administration. These results
      demonstrated antihypertensive activity of an analog of propranolol and support
      the concept that the antihypertensive effects of propranolol may be mediated
      through a metabolite.

PMID- 1015907
TI  - A comparison of skeletal, cardiac, and smooth muscle actions of dantrolene sodium
      -a skeletal muscle relaxant.
AB  - Dantroline sodium, a skeletal muscle relaxant, has been proposed to inhibit the
      relase of Ca++ from the sarcoplasmic reticulum. Such a mechanism suggests that
      other muscle contractile systems operating with the same Ca++ denominator should
      also be affected by the drug. In the present studies dantrolene sodium effects on
      smooth, cardiac and skeletal muscle have been evaluated with in situ and in vitro
      techniques. In anesthetized dogs in situ skeletal muscle contractions were
      inhibitied in a dose-dependent manner, but cardiac muscle contractions were not.
      Effects on intestinal smooth muscle responses were highly variable and of short
      duration. In vitro, ED50 values were developed with dantrolene sodium (0.15-120
      mg/l) in DMSO for each tissue. Skeletal muscle was the most sensitive (ED50 = 4.1
      mg/l), cardiac muscle contractions were not inhibited by the drug and intestinal
      smooth muscle (ED50 = 59.0 mg/l) was approximately 1/14 as sensitive as skeletal
      muscle. It is concluded that skeletal muscle is uniquely sensitive to dantrolene
      sodium. A hypothesis for this specific action is offered.

PMID- 1015908
TI  - The effect of acetylcholine on biliary excretion of ouabain in the physostigmine
      pretreated isolated perfused rat liver.
AB  - The effect of acetylcholine (ACh) on bile flow and biliary excretion of 3H
      ouabain was studied in the physostigmine pretreated isolated perfused rat liver.
      ACh added into the perfusion medium to give a concentration of 1 X 10(-4)M after
      the addition of physostigmine (2 X 1 X 10(-5)M) transiently decreased bile flow
      and biliary concentration of tritium, originated from 3H-ouabain. A deficit of 34
      mul of bile during the decreased bile flow could be calculated, compared to the
      control group. This deficit in bile flow possibly reflects an inhibitory
      secretory effect of ACh on canalicular bile secretion, or enhanced reabsorption
      of water in the biliary tree. The decline in the concentration of 3H-oubain in
      the bile after the addition of ACh indicates that ACh inhibits biliary transport
      of ouabain by an unknown mechanism, in addition to its effect on bile flow.
      Physostigmine alone possibly was without an effect on biliary elimination of
      ouabain. The results show that ACh retards the biliary elimination of ouabain
      through its influence on bile flow and biliary concentraton of ouabain.

PMID- 1015909
TI  - [Effect of intravenous disopyramide on the hemodynamics of patients hospitalized
      in intensive care units].
AB  - A single dosis of disopyramide (100 mg), given intravenously in 10 min to 30
      patients admitted in the coronary or respiratory care unit, induces a reduction
      of cardiac output of 13.4%, which is highly statistically significant, without
      altering the systemic and pulmonary pressures. The heart rate is also slightly
      diminished.

PMID- 1015910
TI  - [Heart and circulatory effects of quinidine stereoisomers].
AB  - Quinidine sulfate shows dose-related activity. On the cardio-vascular system of
      anaesthetized cats. It reduces heart rate, prolongs QRS and QT of the ECG, lowers
      peripheral blood pressure and depresses slightly myocardial contractility.
      Quinidine hydrochloride lowers blood pressure but alters the ECG only in very
      high doses. Epiquinidine has no blood pressure lowering activity. According to
      the Easson and Stedman hypothesis this may be the result of stereoselectivity of
      alpha-adrenergic receptors. Only very high doses of the epimer produce a
      transient decrease of blood pressure. The ECG-waves are, however, markedly
      altered. QT is prolonged only with epiquinine-epiquinidine-sulfate. The salts of
      epiquinidine tested are much better water-soluble than those of quinidine.

PMID- 1015911
TI  - An increase of liver uptake of thyroxine, an initial step of an increased fecal
      loss of thyroxine in response to propylthiouracil in rats.
AB  - Propylthiouracil augmented fecal loss of thyroxine (T4), but methimazole was
      without effect in this respect in rats. In vitro uptake of labeled T4 by the
      liver was significantly enhanced by a small amount of propylthiouracil in the
      presence of dilute rat plasma. Methimazole was without effect under comparable
      conditions. In contrast, propylthiouracil and methimazole failed to affect in
      vitro uptake of labeled T4 by the kidney and diaphragm in the presence of dilute
      rat plasma. Since deiodination of T4 does not occur in the presence of dilute rat
      plasma, it is suggested that propylthiouracil specifically stimulates liver
      uptake of T4 as an initial step of an increase of biliary-fecal excretion of T4
      in rats.

PMID- 1015912
TI  - Neurotoxicity of digitoxin in adult and newborn rats: drug distribution.
AB  - Electrocardiographic monitoring of adult and 1 week old (newborn) rats during
      severe acute digitoxin toxicity demonstrated a lack of acrdiotoxicity despite
      marked neurotoxicity in both age groups. To examine the possibility that drug
      disposition is a factor in the unusual digitoxin sensitivity of newborn rats, 3H
      digitoxin distribution in liver, heart, brain, kidney, adrenal, blood and fat was
      compared in 1 and 3 week old (weanling) rats at 2, 12 and 24 hr. H3-label was
      rapidly sequestered by the liver in weanlings but not in newborn rats. Newborns
      had significantly higher concentrations of 3H-substance in all other organs,
      particularly in brain (greater than 25% of the administered dose at 24 hr),
      indicating a cerebrotoxic basis for the newborn's sensitivity to digitoxin. Only
      trace amounts of 3H-substance were recovered from adult rat brain during severe
      neurotoxicity (72 hr) suggesting that digitoxin metabolites may be potent
      cerebrotoxins. Extremely high adrenal concentrations were noted in all animals.

PMID- 1015913
TI  - The effects of digitoxin and its metabolites on the transmembrane potential and
      contractile characteristics of guinea-pig ventricle strips.
AB  - The effects of 10(-7) and 10(-6) M digitoxin, and some of its metabolites,
      digitoxigenin-bis-digitoxoside, digitoxigenin-mono-digitoxoside and digitoxigenin
      on the transmembrane potential and contractile characteristics of guinea-pig
      right ventricle strips were studied to define the role of the sugar side-chain in
      these cleavage products of digitoxin. Digitoxin and digitoxigenin produced their
      maximum inotropic responses, without induction of arrhythmias, at about 30 min.
      However, the bis and mono compounds produced arrhythmias within 12 min, so the
      inotropy recorded may not be the maximum response. Digitoxin with 3 sugar
      residues and the bis compound with 2 sugar residues produced a prolongation in
      the action potenital duration. In contrast, the mono compound with one sugar
      residue and the digitoxigenin with no sugar residue produced a shortening of the
      action potential duration. There may be a relationship between the number of
      sugar moieties and the action potential duration; digitoxin and its bis
      derivative increased the action potential duration and mono- and digitoxigenin
      decreased the action potential duration. There also appeared to be an unusual
      relationship between the number of sugar moieties and induction of arrhythmias;
      arrhythmogenicity occurred at the doses employed with only the bis- and mono
      digitoxoside. Finally, there appeared to be no simple relationship between
      chemical structure and inotropic potency.

PMID- 1015914
TI  - Relationships between chronotropic effect, 1-3H-noradrenaline uptake and tissue
      concentrations of desipramine, protripyline and doxepin in rat isolated atria.
AB  - The pharmacological effects of three tricyclic antidepressant agents
      (desipramine, protriptyline and doxepin) are evaluated in rat isolated atria in
      relation to their accumulation and efflux kinetics. The pharmacological effects
      studed are: inhibition of 1-3H-noradrenaline uptake, potentiation of 1
      noradrenaline chronotropic response, and changes in spontaneous atrial rate. All
      drugs inhibit noradrenaline uptake and potentiate noradrenaline chronotropic
      response (desipramine congruent to protriptyline greater than doxepin).
      Desipramine and protriptyline, at concentrations of 10(-7) -- 10(-6)M stimulate
      the spontaneous rate; higher concentrations (greater than 10(-6)M) depress it.
      Doxepin has only a negative chronotropic effect. When the drugs are removed from
      the incubation medium, the depressing effect starts to disappear immediately for
      doxepin and desipramine and after 20 min for protriptyline. On the contrary the
      stimulating effect persists after repeatedly washing the preparations.
      Desipramine, protriptyline and doxepin extensively accumulate in the myocardial
      tissue (desipramine larger than or equal to protriptyline greater than doxepin).
      In the efflux studies doxepin is washed out more rapidly than desipramine and
      protriptyline. Although the kinetics of uptake and efflux of the three compounds
      are not sufficient to interpret their different pharmacological activities in
      isolated atria, they give useful information on the persistance of the
      sympathomimetic effect and the rapid disappearing of the negative chronotropic
      effect after washing.

PMID- 1015915
TI  - Calcium-dependent, iproveratril-resistant contractions of aortic strips induced
      by a convulsant barbiturate.
AB  - At 3 X 10(-5) M concentratons, 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid
      (CHEB) causes a contraction of rabbit aortic strips that is equivalent to about
      half of the maximal response to norepinephrine. If a calcium-free medium is
      substituted for normal bathing solution and drug is added immediately thereafter,
      there is no response to the convulsant barbiturate but a nearly normal response
      to norepinephrine. When calcium is replaced in stepwise increments, the
      contractor response to CHEB appears in corresponding increments. The prompt
      influence of changes in external calcium-concentration suggests that CHEB-induced
      contraction occurs as a result of calcium influx into cells rather than a release
      of free calcium from previously accumulated intracellular stores. CHEB effect,
      like that of potassium, is prevented by pretreatment with lanthanum (5 X 10(
      3)M). CHEB differs from potassium in that its effects are even more sensitive to
      changes in extracellular calcium concentration. Nevertheless, CHEB can contract
      aortic strips in the presence of iproveratril at a concentration (10(-4)M) that
      blocks all response to potassium (100 mM).

PMID- 1015916
TI  - Effect of some antihypertensive drugs and catecholamine depletors on the plasma
      renin activity in the rat.
AB  - The effect of some antihypertensive drugs and catecholamine depletors on the
      plasma renin activity (PRA) has been investigated in the rat. Diazoxide and CIBA
      4416-Go. increased and clonidine decreased the PRA significantly. The increase in
      PRA following diazoxide was partially blocked by oxprenolol, adrenalectomy and
      demedullation. Adrenal cortex does not seem to contribute to this increase in PRA
      following diazoxide. Pretreatment of rats with reserpine, guanethidine or 6
      hydroxydopamine alsine, guanethidine and 6-hydroxydopamine when given acutely or
      repeatedly (for 3 days) did not produce any significant change in PRA. It is
      concluded that vasodilators like diazoxide and CIBA 4416-Go. increase PRA
      resulting from sympathetic activation which follows hypotension; this increase is
      blocked by catecholamine depletors like reserpine, guantethidine and 6
      hydroxydopamine.

PMID- 1015917
TI  - Role of neuronal and extraneuronal factors in temperature mediated responsiveness
      of adrenoceptors.
AB  - Changes in bath temperature caused changes in the adrenergic responsiveness of
      rabbit iris dilator muscle as indicated by shifts in dose-response curves along
      the log axis and changes in maximum responses. Responses of control tissues to an
      alpha agonist (norepinephrine) were increased at lower temperatures and responses
      to a beta agonist (isoprenaline) were increased at higher temperatures. Responses
      of control tissues were compared with responses of tissues pretreated with
      cocaine or with responses of adrenergically denervated tissues (chemical and
      surgical). Changes in ED50 values with temperature change are similar in control,
      cocaine pretreated or denervated muscles. In contrast, changes in maximum
      response with temperature change are reversed by cocaine pretreatment or
      denervation. Pretreatment of tissues with an inhibitor of catechol-o-methyl
      transferase (tropolone) or an inhibitor of monoamine oxidase (iproniazid) did not
      affect the temperature sensitivity of adrenoceptors. Also, responses to
      terbutaline, a beta agonist not susceptible to catechol-o-methyl transferase,
      changed with temperature. These data indicate that for rabbit iris dilator muscle
      both a neuronal and an extraneuronal component are involved in adrenoceptor
      response changes induced by temperature change and that changes in rates of
      activity of metabolizing enzymes are not involved.

PMID- 1015918
TI  - Effects of droperidol on cardiovascular adrenoceptors.
AB  - The influence of droperidol on the pressor effect of noradrenaline was
      investigated in pithed rats injected with propranolol. Droperidol induced a dose
      dependent shift of the noradrenaline dose-response curve to the right, but proved
      to be 20 times less potent than phentolamine. Droperidol produced a considerably
      more pronounced inhibition of the effect of tyramine than of that of
      noradrenaline.--The influence of droperidol on the increase in tension induced by
      noradrenaline was determined in isolated aortic strips of rats. The drug caused a
      marked parallel shift of the noradrenaline concentration-response curve to the
      right (pA2:7.99). In this preparation droperidol and phentolamine were
      equieffective.--Droperidol did not produce a significant shift of the
      noradrenaline concentration-response curves obtained for the positive
      chronotropic and inotropic effects in spontaneously beating right guinea-pig
      atria and in electrically driven left atria, respectively.--It is concluded that
      droperidol is a competitive inhibitor of the vascular alpha-adrenoceptors,
      leaving the beta-adrenoceptors of the heart unaffected, and that it inhibits the
      neuronal uptake mechanism of noradrenaline.

PMID- 1015919
TI  - Differential species sensitivity to the inhibitory effect of cardiac glycosides
      on 3H-1-noradrenaline accumulation by tissue slices.
AB  - Effects of three cardiac glycosides on the accumulation of 3H-1-noradrenaline (3H
      1-NA) by slices of heart and spleen were studied. Ouabain, digitoxin and digoxin,
      all produced a concentration dependent inhibition of 3H-1-NA uptake in both types
      of tissue slices. The maximum amount of 3H-1-NA accumulated as well as the rate
      of uptake was decreased. Digitoxin and ouabain were equipotent; however, digoxin
      was significantly less potent. Tissues from different mamalian specis did not
      exhibit the same degree of sensitivity to the inhibitory effect of cardiac
      glycosides on 3H-1-NA accumulation. Dogs were most sensitive and guinea-pigs an
      order of magnitude less sensitive. Rats were least sensitive by roughly two
      orders of magnitude when compared with guinea-pigs. The relationship of the
      effect of digitalis on 3H-1-NA accumulation to digitalis-induced cardiac
      arrhythmias is discussed. Finally, the pattern of species sensitivity found here
      is compared with that observed in relation to inhibition of Na+-K+-ATPase by
      cardiac glycosides.

PMID- 1015920
TI  - Ouabain cardiotoxicity, a reassessment of methodology.
AB  - The capacity of ouabain (1 mug/kg/min and 2 mug/kg/min) to induce cardiotoxicity
      was explored in control cats and cats after spinal cord transection. In cats
      receiving 1 mug/kg/min, a higher dose of ouabain was needed to produce lethal
      arrhythmias in spinal cats compared to intact cats. However, in cats receiving 2
      mug/kg/min, there was no difference in dose to death between intact and spinal
      cats. At death, the serum level and ventricular contents of ouabain was higher in
      animals with spinal cord transection regardless of the rate of ouabain infusion.
      Thus it appears that determination of the myocardial tissue digitalis
      concentration more accurately reflects the state of digitalis sensitivity than
      the administered dose. Additionally, seemingly paradoxical findings with regard
      to dose are explicable when serum and tissue concentration are simultaneously
      evaluated.

PMID- 1015921
TI  - Haemodynamic effects of prazosin.
AB  - Parzosin, 0.001 to 10 mg/kg, was administered intravenously to anesthetized
      normal rats. In the dose range 0.001 to 0.01 mg/kg, the drug induced highly
      significant, dose-related falls in blood pressure, pulse pressure and heart rate.
      With doses above 0.01 mg/kg, there was a plateau in hypotensive efficacy and a
      diminution in negative chronotropic activity. Both actions of prazosin (0.01
      mg/kg) were unaffected by vagal blockade with atropine, while hypotensive potency
      was unimpaired after beta-adrenoreceptor blockade. The vasodilator, diazoxide,
      lowered blood pressure, widened pulse pressure and caused tachycardia in rats pre
      treated with pentolinium. In contrast, all effects of prazosin were abolished by
      ganglion blockade. These findings, together with the absence of compensatory
      tachycardia or gross renin hypersecretion during prazosin-induced hypotension,
      are compatible with an antisympathotonic mode of action for the drug. However,
      consistent with its effects on cyclic nucleotide distribution, prazosin appears
      to enhance isoprenaline-induced beta-receptor stimulation.

PMID- 1015922
TI  - Effects of scopolamine and methscopolamine on acquisition and retention of rat
      one-way shuttle box behavior and total brain acetylcholine.
AB  - The effects of scopolamine HBr (0.032 to 10.0 mg/kg), methscopolamine Br (1.0 and
      10.0 mg/kg) and 0.36 mg/kg NaBr on acquisition and retention of one-way avoidance
      behavior and total brain acetylcholine (ACh) were studied in male albino rats.
      Compared to equimolar NaBr, scopolamine caused a dose-related impairment in
      acquisition of avoidance responding while methscopolamine did not. Retention of
      avoidance behavior in trained rats was also disrupted, but the detrimental effect
      was smaller and occurred only following large doses of scopolamine. The per cent
      escape behavior was not decreased by any of the treatments. It increased as
      avoidance was decreased. Scopolamine caused a dose-related increase in latency
      and avoidance and escape responding compared to equimolar NaBr. However,
      scopolamine increased the latency of avoidance at lower doses and to a greater
      degree than it increased the latency of escape. Escape latencies were
      significantly increased only at the largest dose (10 mg/kg). These dose-related
      effects of scopolamine were greater during acquisition than during retention.
      Small doses (0.032 mg/kg) shortened latency of avoidance during retention.
      Methscopolamine increased avoidance and escape latencies only at the largest dose
      (10 mg/kg). Scopolamine produced a dose-related decrease in brain ACh which
      correlated well with the per cent avoidance in acquisition (r = 0.95) and
      retention (r = 0.88) trials. It is concluded that a muscarinic cholinergic
      antagonist with central actions like scopolamine affects selective aspects of
      avoidance behavior in low doses, and that these changes are highly correlated
      with brain ACh levels.

PMID- 1015923
TI  - The effect of apomorphine and haloperidol on the RNA content of brain structures
      of the rat.
AB  - At a dose of 0.5 mg/kg, apomorphine caused an increase of the RNA content of the
      septal nucleus of rats (n. medialis + n. lateralis + n. accumbens); after 2.5
      mg/kg this effect became more marked and, in addition, there was an increase of
      RNA in the caudate nucleus. All effects were antagonized by 0.5 mg/kg of
      haloperidol. These data suggest that apomorphine acts, at different dose levels,
      on different sites of the brain. This might be related to the also different
      behavioral effects of apomorphine at those two dose levels. Haloperidol on its
      own caused a fall of RNA in the amygdaloid nucleus which was not counteracted by
      any of the two doses of apomorphine. Neither drug had any influence on
      hypothalamic RNA concentration.

PMID- 1015924
TI  - The local anesthetic activity of saxitoxin alone and with vasoconstrictor and
      local anesthetic agents.
AB  - STX (saxitoxin), alone and with various vasoconstrictor and local anesthetic
      agents, was evaluated for its ability to produce topical anesthesia on the rabbit
      cornea, peripheral nerve block in the rat, and epidural anesthesia in the dog.
      High frequency and long duration of block can be attained if sufficiently high
      concentrations of STX are used, although latency is long and the doses used may
      produce systemic toxicity. Frequency of satisfactory blocks and mean duration of
      block can be increased and systemic toxicity reduced if STX is administered with
      a vasoconstrictor agent. Conventional local anesthetic agents also enhance the
      nerve blocking activity of STX. When appropriate concentrations of STX,
      vasoconstrictor and local anesthetic agents are used, systemic toxic effects are
      not manifested and the blocks produced exhibit the rapid onset and high frequency
      of block characteristic of the local anesthetic agent and the remarkably long
      duration of STX.

PMID- 1015925
TI  - On the mechanism of action of bombesin on gastric and pancreatic secretion of the
      chicken.
AB  - The present experiments have been carried out in order to establish whether the
      stimulatory effect of bombesin on the chicken gastric acid secretion is a direct
      effect or is mediated by the release of hormones, such as the Avian Pancreatic
      Petide and/or Gastrin. removal of the pancreas, which is known to be the site of
      starage of the Avian Pancreatic Polypeptide, does not produce any decrease of the
      stimulant effect of bombesin on gastric secretion. Removal of the zone between
      the gizzard and duodenum, which shows histological features similar to those of
      the mammalian antrum and in which gastrin cells have been described, sharply
      decreases the basal values of gastric secretion as well as the stimulant effect
      of bombesin, while the effectiveness of caerulein, a gastrin-like peptide
      directly acting on oxintopeptic cells, is maintained. In chickens deprived of the
      duodenum-gizzard zone, bombesin shows a stimulant effect on pancreatic secretion
      indistinguishable from that observed in intact animals. It is concluded that the
      gastric but not pancreatic, action of bomtesin is mediated through the release of
      a factor(gastrin) from the gizzard-duodenum junction. Release of Avian Pancreatic
      Polypeptide from the pancreas is not involved in the mechanism of the action of
      bombesin on gastric secretion of the chicken.

PMID- 1015926
TI  - Anti-ulcer activity of colloidal bismuth subcitrate in Shay-rats.
AB  - The anti-ulcer action of colloidal bismuth subcitrate (CBS) was tested in rats
      with a ligated pylorus (the Shay preparation). The liquid form used in the clinic
      displayed a dose-related inhibition of gastric ulceration. the recently developed
      solid form appeared to be just as effective. On the other hand, non-processed,
      non-colloidal bismuth salts and the CBS vehicle blank were completely inactive.
      The anti-ulcer activity of CBS was found to be unrelated to its buffering
      capacity.

PMID- 1015927
TI  - Effect of furosemide on renal hilar lymph flow.
AB  - Furosemide is known to increase total renal blood flow. The purpose of this study
      was to determine the relationship between this hemodynamic change and renal hilar
      lymph flow. Renal blood flow was measured with an electromagnetic flowmeter
      placed on the left renal artery of anesthetized dogs. Lymph was collected from a
      cannulated hilar vessel. Urine volume loss was not replaced. In the first 10 min
      after furosemide (1 mg/kg i.v.), lymph flow was significantly increased and then
      declined toward control within 30 to 40 min. The decline in lymph flow lagged
      behind the decline in blood flow by about 10 min. In 11 experiments in which
      there was a significant increase in renal blood flow, renal hilar lymph flow also
      increased. In 5 experiments in which renal blood flow did not increase after
      furosemide, lymph flow also did not increase. In both groups, urine volume was
      significantly increased but the diuresis was less in the group in which renal
      blood flow and lymph did not increase. When hydrochlorothiazide (5 mg/kg, i.v.)
      was administered, neither renal blood flow nor hilar lymph flow was altered. The
      effect of equi-diuretic doses of furosemide and hydrochlorothiazide on renal
      tissue water content were compared. The amount of water present after furosemide
      was significantly greater than the amount present after hydrochlorothiazide.
      These data support the concept that changes in renal hilar lymph flow are more a
      consequence of changes in renal blood flow than in urine volume.

PMID- 1015928
TI  - [Comparative study, in the anesthetized dog, of the dromotropic effects of N
      propyl ajmaline bitartrate, ajmaline hydrochloride and ajmaline
      monochloroacetate, by recording of His electrogram].
AB  - A-V and intraventricular conduction disturbances induced by 3 different salts of
      ajmaline: N-propyl ajmaline bitartrate (NPAB), hydrochloride (CHA) and mono
      chloro-acetate (MCAA), were studied by recording endocavitary His bundle activity
      in pentobarbital anesthetized dogs. Cumulative dose-response curves were obtained
      with 3 doses of each compound. The results demonstrate that: a) NPAB exerts a
      significant depressor effect (9 to 10 times more potent than CHA) on the
      following three conduction times: auriculo-Hisian, His-Pinkinje and Purkinje
      ventricular; b) on His-Purkinje and intra ventricular conduction, MCAA exerts a
      weaker depressor effect than that of Nab. The lack of parallelism of dose
      response curves prevents further  comparative quantification; c) on atrio-hisian
      conduction, MCAA presents a delayed dose-related depressor effect suggesting the
      presence of an active metabolite. It is concluded that among ajmaline derivatives
      studied, Nab appears to be the most depressor on A-V and intraventricular
      conduction in the pentobarbital anesthetized dog.

PMID- 1015929
TI  - [Seroepidemiologic study of human cysticerosis in the predominantly indigenous
      rural Indian population of the State of Chiapas].
AB  - The overall proportion of sera with antibodies against cyticercus antigens in
      3226 serum samples collected among the Indian rural population in the proximity
      of San Cristobal de Las Casas, Chiapas, Mexico is 0.49. The proportion of
      positive sera varied from 0.4 to 7.6% inversely with the number of inhabitants in
      the community. The global proportion of positive sera in Chiapas being
      considerably lower than that expected from the autopsy frequency of brain
      cysticercosis in Mexico City (1.4-3.6%), it is perhaps indicative of different
      epidemiologic dynamics in rural and urban areas.

PMID- 1015930
TI  - [Determination of delta aminolevulinic acid in urine in a population exposed to
      lead].
AB  - Uninary levels of delta-aminolevulinic acid (ALA) were determined in 93 workers
      exposed to lead. Control groups were made up of 32 employees of the same
      factories of test group and of 24 patients with no history of lead exposure. In
      the first group, urinary concentration of ALA was 28.55 mg/1; it was 3.36 mg/1 in
      the second group and 2.98 mg/1 in the other control group. Differences between
      workers and controls were statistically significant.

PMID- 1015931
TI  - [Experimental study of post-labyrinthectomy compensation by means of the torsion
      pendulum].
AB  - Recovery patterns after unilateral labyrinthectomy were studied using a torsion
      pendulum to produce angular accelerations in unanaesthetized, immovilized cats.
      The oculomotor activity before and during angular accelerations was recorded and
      cuantified in 10 post-labyrinthectomized cats during 26 days of recovery both
      with and without environmental fixation (eyes open or covered). The integrated
      nistagmus obtained with rotation in each direction was used as a measure of
      oculomotor activity, as well as an indicator of directional preponderance. It was
      found this indicator to be far more sensitive than the raw electronystagmic
      tracings to detect asymmetries in the oculomotor response. The integrated
      movement of the eyes without ambiental fixation (eyes covered) was consistently
      40% of the pendulum's displacement; while having both eyes open, the ocular
      displacement was equal (100%) to that of the environment. These relations changed
      in a predictable and characteristic way after labyrinthectomy. Approximately
      between 5 and 12 days post-labyrinthectomy, the responses to stimulus in both
      directions become of very small magnitude, indicating a depression of the
      reflexes originating in the remaining normal labyrinth.

PMID- 1015932
TI  - Olfactory nerve reconstitution in the homing pigeon after resection:
      ultrastructural and electrophysiological data.
AB  - Homing pigeons were subjected to uni- or bilateral resection of the olfactory
      nerves. A control of the operated region carried out five months later, showed
      that the olfactory nerves were continuous from the olfactory mucosa to the bulb.
      Cross sections of the regenerated nerve, observed under the electron microscope,
      showed morphological alterations with respect to the normal. Total measurement of
      the cross surface of both olfactory nerves showed that the regenerated nerve is
      always smaller than the intact nerve; this is also apparent in the total number
      of the fibres counted. Electrophysiological tests, performed on the regenerated
      nerve showed that the conduction along the resected nerve is restored.

PMID- 1015933
TI  - Temporal distribution of rapid eye movements and related monophasic potentials in
      the brain stem following injection of an anticholinesterase.
AB  - The temporal distribution of the horizontal rapid eye movements and the related
      monophasic potentials recorded from the ascending MLF following intravenous
      injection of o.i mg/kg of anticholinesterase has been investigated in
      precollicular decerebrate animals. In particular the intervals between individual
      MLF potentials occurring during successive REM episodes have been evaluated over
      a total period of 2000 sec on each experiment. 2. There was a bimodal
      distribution of intervals due to the fact that all the rapid eye movements and
      the related MLF potentials were grouped in bursts which occurred at quite regular
      intervals. 3. During the cholinergically induced episodes of REM, there were
      usually bursts of REM in one direction followed by bursts of REM in the opposite
      direction. The mean number of individual eye movements within each burst was 4.67
      +/- 0.84, S.D., while the average interval between the individual eye movements
      corresponded to 167 +/- 36 msec, S.D. 4. There was a great regularity in the
      periodic occurrence of the bursts of REM. In particular the mean interval between
      the beginning of a burst of REM in one direction (i.e., towards the left side)
      and that of the next train oriented in the opposite direction (i.e., towards the
      right side) was 1.97 +/- 0.47 sec, S.D., while the mean interval between the
      beginning of this last train and that of the successive train oriented in the
      former direction corresponded to 2.97 +/- 0.48 sec, S.D. Moreover, the duration
      of the whole period corresponding to the interval between two successive bursts
      of REM oriented in the same direction (i.e., towards left or towards right)
      corresponded on average to 4.94 +/- 0.55 sec S.D. and 4.99 +/- 0.52 sec, S.D.
      respectively. 5. In addition to these "simple bursts" of rapid eye movements
      oriented in one direction, there were "complex bursts" in which an alternation of
      the individual eye movements within each burst was observed. In these instances
      the mean number of spikes was greater (5.35 +/- 1.20, S.D.) and the mean interval
      shorter 119 +/- 44 msec, S.D.) than those observed in the "simple bursts", About
      10-15% of the bursts occurring during the cholinergically induced REM episodes
      were of the complex type. 6. These findings obtained from an individual
      experiment were confirmed in all the decerebrate animals treated with the same
      dose of anticholinesterase; only slight quantitative differences were detected
      from case to case. 7. Since the bursts of REM induced by the anticholinesterase
      depend upon the activity of the vestibular nuclei, it is postulated that
      cholinergic reticular neurons activate structures which show waxing and waning in
      their activity before acting on the vestibulo-oculomotor system. This system
      probably contains the inhibitory interneurons which transform the regularly
      modulated input into  a rhythmic vestibular output...

PMID- 1015934
TI  - Study of genetic relationships among marine species of the genera Beneckea and
      Photobacterium by means of in vitro DNA/DNA hybridization.
AB  - Strains representative of species of the marine genera Beneckea and
      Photobacterium were used as reference standards in in vitro DNA/DNA competition
      experiments. Within a given species, strains were found to be related by over 80%
      competition. (Competition was defined as the amount of radioactive DNA displaced
      by heterologous DNA relative to the amount displaced by homologous DNA.) On the
      basis of interspecies competition values (expressed as averages), the following
      groupings could be made: 1. "Photobacterium" fischeri was related to strain ATCC
      15382 by a competition of 38% and was distinct from all the other strains tested
      (competition less than or equal to 11%). 2. The genus Photobacterium consisted of
      3 species, P.phosphoreum, P.leiognathi, and a newly designated species,
      P.angustum (composed of non-luminous strains). The latter species was found to be
      related to P.leiognathi and P.phosphoreum by 56 and 28% competition,
      respectively, while P.phosphoreum was related to P.leiognathi by 29%. 3. In the
      genus Beneckea, 65% competition was detected between B.harveyi and B.campbellii
      as well as between B.parahaemolytica and B.alginolytica. These pairs of species
      were related to each other by 51-58% and to B.natriegens by 34-56% competition. A
      newly designated pathogenic species, B.vulnifica, appeared to have a low but
      significant relationship to all the above mentioned species of Beneckea. 4. Two
      biotypes, related by 68% competition, were recognized in the species B.splendida.
      Similarly, B.pelagia was found to consist of 2 biotypes related by a competition
      of 67%. The competition values between these species were 38-40%. 5. B.nereida,
      B.nigrapulchrituda, and "Vibrio" anguillarum had competition values less than or
      equal to 30% to each other as well as to other species of Beneckea. 6. With
      Vibrio cholerae as the reference standard, V.albensis was found to be related by
      a competition of 82%, while V.proteus and V.metschnikovii had competition values
      of 22 and 12%, respectively. These results suggested that V.albensis should be
      synonymized with V.cholerae, while the latter two organisms should remain
      distinct from this species. V.cholerae as well as the other terrestrial organisms
      tested did not appear to be significantly related to any of the marine strains
      (competition values less than or equal to 27%). The speciation derived from the
      results of the DNA/DNA competition experiments was compared to previous
      speciation based on phenotypic similarities.

PMID- 1015935
TI  - Chemotaxis in Actinoplanes.
AB  - The chemotactic properties of spores of Actinoplanes brasiliensis were examined.
      The spores are attracted to chloride and bromide solutions but not to a number of
      organic compounds that are capable of supporting growth in chemically defined
      media. Chloride attraction has been tested in several other species of the genus
      and in a number of Actinoplanes strains isolated from soils. Some are attracted
      to chloride, but most strains are indifferent to the halide. In dense
      suspensions, the spores of A. brasiliensis show an apparent microaerophilic
      behavior. The ecolotical implications of the chemotactic properties of the A.
      brasiliensis spores are discussed.

PMID- 1015936
TI  - The effect of a non-metabolizable analog on mandelate catabolism in Pseudomonas
      putida.
AB  - DL-2,3,4,5,6-pentafluoromandelic acid (PFM) specifically inhibits the growth of
      Pseudomonas putida (ATCC 12633) on medium containing mandelate as sole carbon and
      energy source by competitive inhibition of mandelate dehydrogenase. PFM is not
      metabolized and is neither an inducer of the mandelate catabolic enzymes nor an
      antagonist of induction. Mutants resistant to the inhibitory effects of PFM
      (PFMr) were isolated; most prove to be superinducible, i.e. synthesize
      corrdinately the mandelate-specific catabolic enzymes at elevated levels
      following induction. In at least one case the PFMr mutation maps very near the
      structural genes that encode the enzymes functional in the first two steps of
      mandelate catabolism. It is reasoned that the PFMr mutation is of the promotor
      type. Resistance to substrate analogs such as PFM offers a general method for
      isolation of regulatory mutants in catabolic metabolism.

PMID- 1015937
TI  - Desulfuromonas acetoxidans gen. nov. and sp. nov., a new anaerobic, sulfur
      reducing, acetate-oxidizing bacterium.
AB  - Anaerobic sea or fresh water media with acetate and elemental sulfur yielded
      enrichments of a new type of strictly anaerobic, rod-shaped, laterally
      flagellated, Gram-negative bacterium. Three pure culture-strains from different
      sulfide-containing sea water sources were characterized in detail and are
      described as a new genus and species Desulfuromonas acetoxidans. The new
      bacterium is unable to ferment organic substances; it obtains energy for growth
      by anaerobic sulfur respiration. Acetate, ethanol or propanol can serve as carbon
      and energy source for growth; their oxidation to CO2 is stoichiometrically linked
      to the reduction of elemental sulfur to sulfide. Organic disulfide compounds,
      malate or fumarate are the only other electron acceptors used. Butanol and
      pyruvate are used in the presence of malate only; no other organic compounds are
      utilized. Biotin is required as a growth factor. The following dry weight yields
      per mole of substrate are obtained: in the presence of sulfur: 4.21 g on acetate,
      9.77 g on ethanol; in the presence of malate: 16.5 g on acetate, 34.2 g on
      ethanol and 46.2 g on pyruvate. Accumulations of cells are pink; cell suspensions
      exhibit absorption spectra resembling those of c-type cytochromes (abs. max. at
      419, 523 and 553 nm). Malate-ethanol grown cells contain a b-type cytochrome in
      addition. In the presence of acetate, ethanol or propanol, Desulfuromonas strains
      form robust growing syntrophic mixed cultures with phototrophic green sulfur
      bacteria.

PMID- 1015938
TI  - Characterization of a benzoate permease mutant of Pseudomonas putida.
AB  - A spontaneous mutant of Pseudomonas putida (PRS 2017) has been isolated which is
      incapable of growth on benzoate, does not induce the enzymes of the catechol
      branch of the beta-ketoadipate pathway when grown in the presence of benzoate,
      cannot accumulate radioactively labeled benzoate, yet grows well with mandelate
      as sole source of carbon and energy. This strain apparently lacks a benzoate
      permease, which in the wild type shows a Km of about 0.1 mM for benzoate, is
      inducible, and is not under the control of the regulatory system which governs
      the induction of the enzymes of the catechol branch of the beta-ketoadapate
      pathway. The lesion in PRS2017 is apparently single site and maps near other
      genes governing benzoate dissimilation.

PMID- 1015939
TI  - The uptake of 2-ketogluconate by Pseudomonas putida.
AB  - The uptake of 2-ketogluconate is inducible in Pseudomonas putida: 2
      ketogluconate, glucose, gluconate, glycerol and glycerate were each good
      nutritional inducers of this ability. 2-Ketogluconate uptake obeyed saturation
      kinetics (apparent Km in 2-ketogluconate-grown cells was 0.4 mM). 2-Ketogluconate
      was transported against a concentration gradient, apparently in an unchanged
      state, and the process required metabolic energy, all of which indicate an active
      transport system. A number of independently isolated mutants with deranged
      activity of a common glucose-gluconate uptake system were found to be also
      defective in 2-ketogluconate transport. Strains unable to transport 2
      ketogluconate which grew readily on glucose and gluconate were also isolated.
      These results suggest that 2-ketogluconate transport is governed by at least two
      genetic elements: one which is also required to take up glucose and gluconate and
      another which appears to be specific for 2-ketogluconate transport. Similarly,
      glucose and gluconate transport appears to require at least one factor which is
      not necessary for 2-ketogluconate transport, as suggested by the lack of
      induction of the common glucose-gluconate uptake system by glycerol and
      glycerate, substrates which are good inducers of 2-ketogluconate uptake.

PMID- 1015940
TI  - The bacterial oxidation of nicotinic acid. N-formylmaleamic and N-formylfumaramic
      acids.
AB  - N-Formylmaleamic acid, a probable intermediate in the bacterial metabolism of
      nicotinic acid, has been synthesized by photoisomerization of its trans isomer, N
      formylfumaramic acid. The compound previously reported to be N-formylmaleamic
      acid has been shown to be N-formylfumaramic acid.

PMID- 1015941
TI  - Fatty acid composition of selected prosthecate bacteria.
AB  - The cellular fatty acid composition of 14 strains of Caulobacter speices and
      types, two species of Prosthecomicrobium, and two species of Asticcacaulis was
      determined by gas-liquid chromatography. In most of these bacteria, the major
      fatty acids were octadecenoic acid (C18:1), hexadecenoic acid (C16:1) and
      hexadecanoic acid (C16:0). Some cyclopropane and branched chain fatty acids were
      detected in addition to the straight chained acids. Hydroxytetradecanoic acid was
      an important component of P.enhydrum but significant amounts of hydroxy acids
      were not detected in other prosthecate bacteria examined.

PMID- 1015942
TI  - Bacterial carotenoids. L. Absolute configuration of zeaxanthin dirhamnoside.
AB  - Zeaxanthin dirhamnoside is the major carotenoid of Corynebacterium autotrophicum.
      The absolute configuration 3R,3'R followed from CD-properties of its hexaacetate,
      alpha-L-assignment and 1C4 conformation were concluded from 1H NMR data by
      comparison with model compounds.

PMID- 1015943
TI  - Enzymatic synthesis of poly-beta-hydroxybutyrate in Zoogloea ramigera.
AB  - The enzyme activity synthesizing poly-beta-hydroxybutyrate (PHB) was mainly
      localized in the PHB-containing particulate fraction of Zoogloea ramigera I-16-M,
      when it grew flocculatedly in a medium supplemented with glucose. On the other
      hand, the enzyme activity remained in the soluble fraction when the bacterium
      grew dispersedly in a glucose-starved medium. The soluble PHB synthase activity
      became associated with the particulate fraction as PHB synthesis was initiated on
      the addition of glucose to the dispersed culture. Conversely, the enzyme activity
      was released from the PHB-containing granules to the soluble fraction when the
      flocculated culture was kept incubated without supplementing the medium with
      glucose. PHB synthase was also incorporated into the newly formed PHB fraction
      when partially purified soluble PHB synthase was incubated with D(-)-beta
      hydroxybutyryl CoA in vitro. Although attempts to solubilize the particulate
      enzyme were unsuccessful, and the soluble enzyme became extremely unstable in
      advanced stages of purification, both PHB synthases had the same strict substrate
      specificity for D(-)-beta-hydroxybutyryl CoA, and showed the same pH optimum at
      7.0.

PMID- 1015944
TI  - Purification, some properties and quaternary structure of the D-ribulose 1,5
      diphosphate carboxylase of Alcaligenes eutrophus.
AB  - D-Ribulose 1,5-diphosphate carboxylase has been purified from autotrophically
      grown cells of the facultative chemolithotrophic hydrogen bacterium Alcaligenes
      eutrophus. The enzyme was homogeneous by the criteria of polyacrylamide gel
      electrophoresis. The molecular weight of the enzyme was 505000 determined by gel
      filtration and sucrose density gradient centrifugation, and a sedimentation
      coefficient of 18.2 S was obtained. It was demonstrated by sodium dodecyl
      sulphate-polyacrylamide gel electrophoresis that the enzyme consists of two types
      of subunits of molecular weight 52000 and 13000. Electron microscopy on the
      intact and the partially dissociated enzyme lead to the construction of a model
      for the quaternary structure of the enzyme which is composed of 8 large and 8
      small subunits. The most probable symmetry of the enzyme molecule is 4:2:2.
      Michaelis constant (Km) values for ribulose 1,5-diphosphate, Mg2+, and CO2 were
      0.59 mM, 0.33 mM, and 0.066 mM measured under air. Oxygen was a competitive
      inhibitor with respect to CO2 suggesting that the enzyme also exhibits an
      oxygenase activity. The oxygenolytic cleavage of ribulose 1,5-diphosphate was
      shown and a 1:1 stoichiometry between oxygen consumption and 3-phosphoglycerate
      formation observed.

PMID- 1015945
TI  - On the mechanism of salt tolerance. Production of glycerol and heat during growth
      of Debaryomyces hansenii.
AB  - As glycerol was suggested as an osmotic agent in the salt tolerant Debaryomyces
      hansenii the concentrations of total, intracellular, and extracellular glycerol
      produced by this yeast was followed during growth in 4 mM, 0.68 M, and 2.7 M NaCl
      media. The total amount of glycerol was not directly proportional to biomass
      production but to the cultural salinity with maximum concentrations just prior to
      or at the beginning of the stationary phase. In all cultures the cells lost some
      glycerol to the media, at 2.7 M NaCl the extracellular glycerol even amounted
      maximally to 80% of the total. A distinct maximum of intracellular glycerol,
      related to dry weight or cell number, appeared during the log phase at all NaCl
      concentrations. As the intracellular calculated glycerol concentrations amounted
      to 0.2 M, 0.8 M, and 2.6 M in late log phase cells at 4mM, 0.68 M, and 2.7 M
      NaCl, respectively, whereas the corresponding analysed values for the glycerol
      concentrations of the media were 0.7 mM, 2.5 mM, and 3.0 mM, glycerol contributes
      to the osmotic balance of the cells. During the course of growth all cultures
      showed a decreasing heat production related to cell substance produced, most
      pronounced at 2.7 M NaCl. At 2.7 M NaCl the total heat production amounted to-
      1690 kJ per mole glucose consumed in contrast to--1200 and--1130 kJ at 4 mM and
      0.68 M NaCl, respectively. The Ym-values were of an inverse order, being 129,
      120, and 93 at 4 mM, 0.68 M, and 2.7 M NaCl respectively.

PMID- 1015946
TI  - Spirochaeta halophila sp. n., a facultative anaerobe from a high-salinity pond.
AB  - A facultatively anaerobic spirochete isolated from a high-salinity pond grew
      optimally when 0.75 M NaCl, 0.2 M MgSO4, and 0.01 M CaCl2 were present in media
      containing yeast extract, peptone, and a carbohydrate. The organism failed to
      grow when any one of these three salts was omitted from the medium. Aerobically
      grown colonies of the spirochete were red, whereas anaerobically-grown colonies
      showed no pigmentation. Non-pigmented mutants of the spirochete were isolated.
      The spirochete used carbohydrates, but not amino acids, as energy sources.
      Glucose was fermented to CO2, H2, ethanol, acetate, and a small amount of
      lactate. Determinations of radioactivity in products formed from glucose-1-14C
      and enzymatic assays indicated that glucose was dissimilated to pyruvate mainly
      via the Embden-Meyerhof pathway. Pyruvate was metabolized through a clostridial
      type clastic reaction. Cells growing aerobically performed an incomplete
      oxidation of glucose mainly to CO2 and acetate. Comparison of aerobic and
      anaerobic growth yields indicated that oxidative phosphorylation occurred in
      cells growing aerobically. The guanine + cytosine content of the DNA of the
      spirochete was 62 moles %. It is proposed that the spirochete described herein be
      considered a new species and that it be named Spirochaeta halophila.

PMID- 1015947
TI  - Hyphal tip growth in Phytophthora. Gradient distribution and ultrahistochemistry
      of enzymes.
AB  - Germinating cysts and isolated walls from germinating cysts incorporated 14C-UDPG
      into wall material of which 22.5 and 15% respectively were insoluble in boiling 1
      N HCl, indicating that part of the synthetase activity is located in the wall
      itself. A combination of Urografin and Ficoll density gradients was used to
      separate various intracellular fractions. A consistent separation of beta
      glucanase and UDPG-transferase enriched fractions was achieved. The beta
      glucanase fraction contained dictyosome vesicles and fragments along with some
      plasma membranes. The UDPG-transferase fraction was relatively rich in membranes
      resembling rough and smooth ER. The results suggest the two enzymes are
      transported to the wall by different intracellular routes, and two types of
      vesicle may be involved. Alkaline phosphatase, beta-glucosidase and acid
      phosphatase were found extracellularly and their distribution in density
      gradients determined. The results of histochemical staining for acid phosphatase,
      alkaline phosphatase and polysaccharide are described and compared with the
      biochemical data. beta-1,3-glucanase, found intra- and extracellularly, induced
      distorted growth of germ tubes and also removed most of the apical wall when
      added to the incubation medium. None of these responses were observed with
      cellulase. Determinations of the osmotic pressure of germinating cysts and
      incubation medium revealed that the turgor of germinating cysts amounts to about
      1.8 at under the conditions used.

PMID- 1015948
TI  - Growth and pigment production by Arthrobacter pyridinolis n. sp.
AB  - A new bacterium capable of growing on 2-hydroxypyridine as sole source of carbon
      and nitrogen was isolated from soil. During its growth on solid medium,
      approximately 50% of this substrate was converted to a brilliant blue crystalline
      pigment which was deposited extracellularly in the colony mass. The pigment was
      identical to that produced by Arthrobacter crystallopoietes during its growth on
      2-hydroxypyridine. The new isolate exhibited the typical cycle of morphogenesis
      characteristic of the genus Arthrobacter. The organism is different from all
      other reported species of Arthrobacter. It is proposed that the organism be named
      Arthorbacter pyridinolis n. sp.

PMID- 1015949
TI  - Photorespiration in diatoms. IV. Two pathways of glycolate metabolism in
      synchronized cultures of Cylindrotheca fusiformis.
AB  - Cylindrotheca fusiformis is shown to be able to convert glycolate to glycerate
      via tartronic semialdehyde as well as by the better known route involving
      transamination to glycine. Enzymes related to photorespiration were compared in
      light-dark synchronized cultures of C. fusiformis kept in continuous light in a
      complete synthetic seawater medium or starved for nitrogen or silicon. Glycolate
      oxidation remained constant throughout the cell cycle and was unaffected by
      starvation. Transamination of glyoxylate was stimulated by light, inhibited
      during nitrogen starvation, and dramatically stimulated by reintroduction of
      nitrate to the medium. Glyoxylate carboligase was also stimulated by light and
      inhibited during nitrogen-starvation but only partially recovered activity after
      reintroduction of nitrate.

PMID- 1015950
TI  - [Degradation of 4-chlorobenzoic acid by an Arthrobacter species (author's
      transl)].
AB  - An Arthrobacter sp. growing on 4-Chlorobenzoic acid as its sole source of carbon
      excretes 4-hydroxygenzoic acid and protocatechuic acid into the culture medium.
      Protocatechuic acid is further attacked by "meta"-cleavage. During growth of the
      Arthrobacter sp. on benzoic acid cis-cis muconic acid can be isolated from the
      medium, suggesting the involvement of the "ortho"-cleavage pathway. The enzymes
      both for the "meta"- and the "ortho"-cleavage pathway are inducible.

PMID- 1015951
TI  - Chemical and biochemical studies for the differentiation of coagulase-positive
      staphylococci.
AB  - The cell wall composition, the configuration of lactic acid produced from glucose
      under anaerobic conditions, the occurrence of fructose-1,6-diphosphate (FDP)
      activated L-lactate dehydrogenase (L-LDH), and the esterase pattern were
      determined from more than 80 strains of coagulase-positive staphylococci isolated
      from man and animal. Strains isolated from man, swine, bovines and hares form a
      rather homogeneous group. They exhibit a similar cell wall composition, produce
      predominantly D,L-lactate and have a characteristic and simple esterase pattern.
      Coagulase-positive staphylococci isolated from dogs, horses, minks and pigeons
      are quite distinct from typical Staphylococcus aureus strains. They exhibit a
      different cell wall composition, produce only L-lactate, possess an L-LDH which
      is specifically activated by FDP, and have a quite complex esterase pattern.

PMID- 1015952
TI  - [Mechanism of the variation of the acetate/lactate/ratio during glucose
      fermentation by bifidobacteria (author's transl)].
AB  - It is demonstrated that most strains of bifidobacteria form much more acetate and
      less lactic acid from glucose than is to be expected according to the breakdown
      of glucose via the "bifidoshunt". The analysis of isotope distribution among the
      fermentation products of glucose labeled in different positions showed that the
      excess of acetate is the result of the phosphoroclastic splitting of a part of
      the pyruvate arising from carbons 4, 5, and 6 of glucose. In addition to acetate
      (carbons 5 and 6), formate is formed from carbon 4 and some acetate is reduced to
      ethanol. The formation of "extra" acetate occurs mainly during the log phase and
      is less pronounced in resting cells. The extent of the phosphoroclastic splitting
      of pyruvate varies considerably among different strains even among those from the
      same species.

PMID- 1015953
TI  - The role of energy-spilling reactions in the growth of Klebsiella aerogenes NCTC
      418 in aerobic chemostat culture.
AB  - When cell-saturating amounts of glucose and phosphate were added to steady state
      cultures of Klebsiella aerogenes that were, respectively, glucose- and phosphate
      limited, the organisms responded immediately with an increased oxygen consumption
      rate. This suggested that in neither case was glucose transport the rate-limiting
      process, and also that organisms must possess effective mechanisms for spilling
      the excess energy initially generated when a growth-limitation is temporarily
      relieved. Steady state cultures of mannitol- or glucose-limited organisms also
      seemingly generated energy at a greater rate than was required for cell synthesis
      since gluconate-limited cultures consumed oxygen at a lower rate, at each
      corresponding growth rate, than did mannitol- or glucose-limited cultures, and
      therefore expressed a higher YO value. Thus, mannitol- and glucose-limitations
      must be essentially carbon (and not energy) limitations. The excess energy
      generated by glucose metabolism is one component of "maintenance" and could be
      used at lower growth rates to maintain an increased solute gradient across the
      cell membrane, imposed by the addition of 2%, w/v, NaCl to the growth
      environment. The maintenance rates of oxygen consumption of K. aerogenes also
      could be caused to increase by adding glucose discontinuously (drop-wise) to a
      glucose-limited chemostat culture, or by exchanging nitrate for ammonia as the
      sole utilizable nitrogen source. The significance of these findings to an
      assessment of the physiological factors circumscribing energy-spilling reactions
      in aerobic cultures of K. aerogenes is discussed.

PMID- 1015954
TI  - Regulation of amino acid transport in growing cells of Streptomyces hydrogenans.
      II. Correlation between transport capacity and growth rate in chemostat cultures.
AB  - The uptake of various amino acids into Streptomyces hydrogenans grown in
      chemostatically and turbidostatically controlled steady state cultures has been
      investigated. A close correlation between transport capacity and the growth rates
      of the cells was found. As shown by kinetic analysis, the increased transport is
      due to elevated maximum uptake rates, the apparent Michaelis constants remaining
      unchanged. Analysis of the unidirectional fluxes of cycloleucine revealed that
      not only the influx is raised as the growth rate is increased but also the
      efflux. Hence, the conclusion is drawn that the growth-rate dependent modulation
      of transport capacity is, at least, partially due to the variation of the
      concentration of active transport components. Since the cells were grown in the
      absence of external amino acids the results suggest that amino acid transport
      into S. hydrogenans is under control of endogenous effectors.

PMID- 1015955
TI  - Induction of D-6-hydroxynicotine oxidase in resting cells of Arthrobacter
      oxidans.
AB  - Resting cell suspensions of Arthrobacter oxidans were shown to synthesize the
      inducible enantiozyme, D-6-hydroxynicotine oxidase, in the presence of D-nicotine
      or D-6-hydroxynicotine. The corresponding L-enantiomers, as well as gamma
      methylaminopropyl-(6-OH-pyridyl-3)-ketone, which is the product of the reaction
      catalyzed by the enzyme, were ineffective as inducers. L-6-Hydroxynicotine
      inhibited induction by D-nicotine and D-6-hydroxynicotine while L-nicotine
      inhibited induction by D-6-hydroxynicotine and had no effect on induction by D
      nicotine. Enzyme induction was also found to be inhibited by glucose, 2-deoxy-D
      glucose and by several intermediates of the tricarboxylic acid cycle. An absolute
      requirement for protein synthesis and for oxygen was also demonstrated to be
      necessary for the reactions involved in the covalent attachment of flavin adenine
      dinucleotide to pre-existing precursor protein to yield the catalytically active
      D-6-hydroxynicotine oxidase.

PMID- 1015956
TI  - Growth of Hansenula polymorpha in a methanol-limited chemostat. Physiological
      responses due to the involvement of methanol oxidase as a key enzyme in methanol
      metabolism.
AB  - Hansenula polymorpha has been grown in a methanol-limited continuous culture at a
      variety of dilution rates. Cell suspensions of the yeast grown at a dilution rate
      of 0.16 h-1 showed a maximal capacity to oxidize excess methanol (QmaxO2) which
      was 1.6 times higher than the rate required to sustain the growth rate (QO2).
      When the dilution rate was decreased to 0.03 h-1, QmaxO2 of cells increased to a
      value of more than 20 times that of QO2. The enzymatic basis for this tremendous
      overcapacity for the oxidation of excess methanol at low growth rates was found
      to be the methanol oxidase content of the cells. The level of this enzyme
      increased from 7% to approximately 20% of the soluble protein when the growth
      rate was decreased from 0.16 to 0.03 h-1. These results were explained on the
      basis of the poor affinity of methanol oxidase for its substrates. Methanol
      oxidase purified from Hansenula polymorpha showed an apparent Km for methanol of
      1.3 mM in air saturated reaction mixtures and the apparent Km of the enzyme for
      oxygen was 0.4 mM at a methanol concentration of 100 mM. The involvement of an
      oxygen dependent methanol oxidase in the dissimilation of methanol in Hansenula
      polymprpha was also reflected in the growth yield of the organism. The maximal
      yield of the yeast was found to be low (0.38 g cells/g methanol). This was not
      due to a very high maintenance energy requirement which was estimated to be 17 mg
      methanol/g cells X h.

PMID- 1015957
TI  - The characterization of the rumen bacterium Eadie's oval, Magnoovum gen. nov.
      eadii sp. nov.
AB  - The rumen bacterium Eadie's Oval was examined by means of cell wall analysis and
      biochemical tests with a view to determine its taxonomic position. The purified
      cell walls contained components consistent with the organism being a Gram
      negative bacterium, and despite its large size no abnormal cell wall constituents
      were found. The biochemical tests indicate that Eadie's Oval is not a member of a
      previously described family. The name Magnoovum gen. nov. eadii sp. nov. is
      proposed.

PMID- 1015958
TI  - [The metabolic interactions between Paramecium bursaria Ehrbg. and Chlorella
      spec. in the Paramecium bursaria-symbiosis. II. Symbiosis-specific properties of
      the physiology and the cytology of the symbiotic unit and their regulation
      (author's transl)].
AB  - The endosymbiotic association of Paramecium bursaria Ehrbg. with Chlorella spec.
      (green Paramecium) was studied both physiologically and cytologically. Comparison
      of the properties of the symbiotic unit with those of the symbiotic partners
      which had been isolated from it revealed the following features and differences:
      1. Up to 6000 lux the photosynthetic capacity of the symbiotic unit is higher
      than that of the isolated symbiotic algae grown independently in mass culture
      under defined conditions. Alga-free Paramecium bursaria (colourless Paramecium)
      show a very low rate of CO2-fixation. 2. The green Paramecium has a higher
      compensationpoint of photosynthesis (4000-5000 lux) than the isolated alga (200
      400 lux). 3. Green paramecia consume less oxygen in darkness than colourless
      organisms but more than the isolated algae. 4. The uptake of carbohydrates from
      the culture medium by green parpmecia is lower than the uptake by alga-free P.
      bursaria but higher than the one of the isolated algae. 5. Symbiotic algae within
      the intact symbiotic unit show tightly packed photosynthetic membranes and an
      intense disposition of starch. In the presence of 3-(3,4-Dichlorophenyl)-1,1
      dimethylurea (DCMU) or in darkness the arrangement of thylakoids is less compact
      and the deposition of starch is reduced. The growth and the number of the
      symbiotic algae in situ is regulated by a complex mechanism to which the
      intracellular level of carbohydrates belongs. The results are discussed in
      connection with ecological aspects of the Paramecium bursaria-endosymbiosis.

PMID- 1015959
TI  - Acetate metabolism in Rhodopseudomonas gelatinosa and several other
      Rhodospirillaceae.
AB  - When Rhodopseudomonas gelatinosa was grown on acetate aerobically in the dark
      both enzymes of the glyoxylate bypass, isocitrate lyase and malate synthase,
      could be detected. However, under anaerobic conditions in the light only
      isocitrate lyase, but not malate synthase, could be found. The reactions, which
      bypass the malate synthase reaction are those catalyzed by alanine glyoxylate
      aminotransferase and the enzymes of the serine pathway. Other Rhodospirillaceae
      were tested for isocitrate lyase and malate synthase activity after growth with
      acetate; they could be divided into three groups: 1. organisms possessing both
      enzymes; 2. organisms containing malate synthase only; 3. R. gelatinosa
      containing only isocitrate lyase when grown anaerobically in the light.

PMID- 1015960
TI  - Macromolecular synthesis and cell division during morphogenesis of Arthrobacter
      crystallopoietes.
AB  - The sphere-rod-sphere morphology cycle of Arthrobacter crystallopoietes was
      accompanied by changes in the rate of growth and the rates of DNA, RNA and
      protein synthesis. The patterns of macromolecule synthesis resembled those found
      in other bacteria during a step-up followed by a step-down in growth rate. During
      the step-up in growth spherical cells grew into rods and macromolecules were
      synthesized in the absence of cell division. During step-down, successive rounds
      of septation produced progressively smaller cells which did not separate and
      remained in chains. The morphology of the cells was dependent on the growth rate
      and could be altered by changing the dilution rate in the malate-limited
      chemostat. Gradual transitions in morphology and gradual increases in
      macromolecule content of the cells occurred as the growth rate was increased in
      the chemostat. Sphere to rod morphogenesis occurred when DNA synthesis was
      inhibited by treatment with mitomycin C or by thymine starvation. The DNA
      deficient rods did not divide and eventually lysed. DNA, RNA and protein
      synthesis were continuously required for the reductive division of rods to
      spheres.

PMID- 1015961
TI  - S-formylgluthathione: the substrate for formate dehydrogenase in methanol
      utilizing yeasts.
AB  - Formaldehyde dehydrogenase and formate dehydrogenase were purified 45- and 16
      fold, respectively, from Hansenula polymorpha grown on methanol. Formaldehyde
      dehydrogenase was strictly dependent on NAD and glutathione for activity. The Km
      values of the enzyme were found to be 0.18 mM for glutathione, 0.21 mM for
      formaldehyde and 0.15 mM for NAD. The enzyme catalyzed the glutathione-dependent
      oxidation of formaldehyde to S-formylglutathione. The reaction was shown to be
      reversible: at pH 8.0 a Km of 1 mM for S-formylglutathione was estimated for the
      reduction of the thiol ester with NADH. The enzyme did not catalyze the reduction
      of formate with NADH. The NAD-dependent formate dehydrogenase of H. polymorpha
      showed a low affinity for formate (Km of 40 mM) but a relatively high affinity
      for S-formylglutathione (Km of 1.1 mM). The Km values of formate dehydrogenase in
      cell-free extracts of methanol-grown Candida biodinii and Pichia pinus for S
      formylglutathione were also an order of magnitude lower than those for formate.
      It is concluded that S-formylglutathione rather than free formate is an
      intermediate in the oxidation of methanol by yeasts.

PMID- 1015962
TI  - Surface coat transformation and capsule formation by Leuconostoc mesenteroides
      NCDO 523 in the presence of sucrose.
AB  - When Leuconostoc mesenteroides NCDO 523 was grown in MRS browth, electron
      microscopy of cells fixed in the presence of ruthenium red showed that the cell
      wall was covered with a thin layer of filamentous material. When MRS-grown cells
      were resuspended in the same medium supplemented with 3.6% sucrose, this surface
      coat doubled in thickness and a number of radial thickenings appeared within it.
      After 3 h, the filamentous component of the surface coat had disappeared leaving
      only the radial projections. The progressive accumulation of polymer to produce a
      capsule visible by light microscopy was observed in only about 20% of the
      population. In this minority of cells, a dense globular dextran composed of
      fibrillar and particulate elements was always produced in the initial stages of
      synthesis. After 18 h, the dextran capsule was generally composed of an inner
      globular and outer fibrillar layer. It appeared that the outer layer was derived
      from the globular dextran of the capsule by a process of dispersion.

PMID- 1015963
TI  - [LD50 values and selenium concentration in rabbit organs after parenteral
      administration of sodium selenite and determination of toxicity of urososelevit
      pro inj].
AB  - The LD50-values of sodium selenite after i/m injection to rabbits was determined
      by means of probit-regression straight line. Simultaneously a combination of
      vitamin E and sodium selenite was tested for toxicity in order to examine the
      effect of vitamin E on the selenium toxicity. The LD50/24h was 2.53 mg sodium
      selenite/kg body mass and in combination with vitamin E (30 IU vitamin E/5 mg
      NaSeO3) 2.73 mg/kg. Furthermore the selenium concentration was determined in
      blood, liver, kidney and muscles of animals which died or were killed after 24 h
      respectively. Not only chemical analysis but also relations of time-dose
      efficiency and significantly increased LD50-values show a certain protective
      effect of vitamin E on selenium intoxication.

PMID- 1015964
TI  - [Effect of noise on the physiological functions in fowl. 1. Effect of primary
      strong noise on the 11-OHKS level in broilers and leghorns].
AB  - The effects of first noises on broilers and white leghorns were tested by plasma
      levels on 11-hydroxycorticosteroid (11-OHKS). The noises were 100 dB, 60 to 8,00
      Hz, and applied 30 minutss to one group of broilers, aged 14, 28, and 56 days,
      and to another group of broilers and white leghorns in adult age. The reactions
      were compared. Acoustic stimulation was followed by temporary activation of the
      hypothalamic pituitary-suprarenal system. The rise of the plasma
      glucocorticosteroid level in leghorns was three times as high as that in adult
      broilers, which was interpreted as a reflection of stronger organic stress.
      Reactions differed in intensity, depending on age as well. Plasma-11-OHKS levels
      went up by 32 per cent maximum in broilers aged 56 days or by 73 per cent in
      animals aged 14 days or 120 per cent in those aged 28 days. The above results
      seemed to support the conclusion that noises of the above quantity and quality
      represented stress on fowl.

PMID- 1015965
TI  - [Effect of noise on the physiological functions in fowl. 2. Adaptation to noise
      of white leghorns and broilers].
AB  - Two experimental groups and series were compared (leghorns and broilers as well
      as two age groups of broilers) for their adaptive responses to repeated noise
      application. The noise was 100 dB and applied daily 30 minutes. The reference for
      comparison was the plasma-11-hydroxycorticosteroid concentration (11-OHKS). The
      results differed somewhat from those obtained earlier from one first short-time
      noise application, in that the rise in plasma glucocorticosteroid concentrations
      dropped from 431 to 210 per cent of the initial values in adult leghorns exposed
      to repeated noise stress over seven days. Adult broilers, however, did not
      exhibit any difference in the magnitude of rise of 11-OHKS concentrations by
      comparison between first and seven days of repeated stress. The initial values,
      however, were reached earlier by repeated noise application.

PMID- 1015966
TI  - [Effect of noise on the physiological functions in fowl. 3. Effects of primary
      and repetitive acoustic stimulation on glucose and free-fatty-acid plasma levels
      in broilers of different age groups].
AB  - The effects of first and repetitive noise applications to broilers, aged 14, 28,
      and 56 days, were tested by the responses of the energetic substrates plasma
      glucose concentration and free fatty acids. The plasma concentrations of glucose
      and free fatty acids in broilers at slaughter age with no exposure to noise were
      higher than those in younger animals. Regular daily noise application of 100 dB,
      60 to 8,000 Hz, for 30 minutes, which began on the first day of age, led to rises
      in the plasma glucose levels of animals aged 56 and 28 days even prior to renewed
      acoustic stimulation, which obviously was a conditioned reflex. Such rises were
      accompanied by decline in plasma concentrations of free fatty acids, which
      phenomenon was attributed to higher initial values of plasma glucose. First as
      well as repetitive noise application led to changes in the plasma content of
      energetic substrates. Both the direction and magnitude of the reaction appeared
      to depend on the given initial value. The plasma level responses of glucose and
      free fatty acids were opposite to one another in all animals, 56 days of age,
      which were exposed to repeated noise.

PMID- 1015967
TI  - [Comparative morphological studies on the vascular systems of testes in cattle,
      swine, horse and dog under functional conditions].
AB  - The metacrylate and latex corrosion techniques were used to establish that the
      vascular system of testes is based on one coherent principle in common domestic
      mammals. The cone-shaped Plexus pampiniformis consists of numerous venous rami,
      between 0.25 mm and 1.0 mm in thickness and forming a dense vascular network,
      which practically encase the spiral-shaped A. spermatica interna (cooling coil
      principle). The testicular veins and arteries in the Tunica albuginea constitute
      a somewhat voluminous layer of vessels for dissipation of heat, with rami
      branching off radially into the testicular parenchyma. Most of the artieral rami
      with radial penetration of the testicular parenchyma turn towards the surface in
      the mediastinum testis for three-shape ramification. The vascular rami are
      characterised by countless meanders, primarily for temperature control, pulse
      flattening for more regular and even blood flow, and blood reflex pumping.

PMID- 1015968
TI  - [Endocrine and sperminogenic testicular function. 7. Relationship between
      testicular and plasma androgen concentrations in boars of different ages].
AB  - Testicular tissue and blood samples (V. spermatica interna) were taken from 32
      boars during castration. The animals were of different age groups. Against this
      background, comparative studies were conducted into the relationships between
      testicular and plasma testosterone. A very close correlation was found to exist
      between the androgen values in testicular tissue and those in the blood plasma of
      V. spermatica interna (r = 0.9795), wich appeared to support the conclusion that
      by determination of blood plasma the androgen content in the testes can be
      established with high probability.

PMID- 1015969
TI  - [Endocrine and sperminogenic testicular function. 8. Relationships between
      testicular and plasma testosterone concentrations as well as between the number
      of Leydig cells in testicular tissue and their cell nucleus volume in boars of
      different ages].
AB  - Testicular tissue and blood samples (V. spermatica interna) were taken from 32
      boars during castration. The animals were different age groups. Against this
      background, studies were conducted into the correlations between testicular and
      plasma testosterone, on the one hand, and the amount of interstitial cells of
      Leydig in testicular tissue as well as the latters' cell nuclei volumes, on the
      other. The results seemed to support the conclusion that any age-dependent
      increase of testicular and plasma testosterone concentrations was caused
      unambigously by an absolute increase in volume of androgenic testicular tissue,
      in concomitance with testicular growth, in other words, by rise in the total
      number of interstitial cells of Leydig.

PMID- 1015970
TI  - [Influence of feeding mixed rations, containing 3 premixed components, on animal
      health in intensively-ground kept broilers with special reference to the
      reduction of perosis].

PMID- 1015971
TI  - [Determination of glucose-6-phosphate dehydrogenase activity in cattle and swine
      erythrocytes using the optical test under optimal measuring conditions].
AB  - To find out optimal measuring conditions for determination of G-6-PDH-activity in
      erythrocytes of cattle and pigs by means of the optical test the dependence from
      nature, concentration and pH of buffer surroundings as well as from concentration
      of substrate (G-6-P), coenzyme (NADP) and activator (Mg++) was studied. From the
      results obtained, best reaction conditions for determination of G-6-PDH-activity
      in this species exist taking the following composition of the measuring sample
      (final concentration): 120 mM TRIS/HCl-buffer, pH 9.0; 10 mM MgSO4; 2 mM G-6-P;
      0.2 mM NADP and 0.1 ml haemolysate in 3.0 ml of the measuring volume. The
      influence of an optimal planning of the reaction conditions on registration of G
      6-PDH-activity in erythrocytes of the farming animals is discussed.

PMID- 1015972
TI  - [Serum lysozyme in ulcerative colitis and Crohn's disease].

PMID- 1015973
TI  - [Serum lysozyme in Crohn's disease and ulcerative colitis].

PMID- 1015974
TI  - [Duodenal intramural hematomas of pancreatic origin (author's transl)].

PMID- 1015975
TI  - [The upward displacement of the right kidney: a frequent radiographic abnormality
      in cirrhosis (author's transl)].

PMID- 1015976
TI  - [Obstructive jaundice caused by pancreatic metastasis from an ocular
      nevocarcinoma operated on 30 years previously].

PMID- 1015977
TI  - [Endocrine testing in the Willi-Prader syndrome].

PMID- 1015978
TI  - [Use of French as the language of scientific publication. Warning concerning the
      "paper drain"].

PMID- 1015979
TI  - [The fate of children with galactosemia].

PMID- 1015980
TI  - [Hereditary fructose intolerance with early onset].
AB  - Four cases of hereditary fructose intolerance with an early onset are reported.
      The features of acute liver failure in the neonatal period include a haemorrhagic
      syndrome, collapse, neurological features, hypoglycaemia, disturbed bleeding and
      clotting studies and abnormal liver function tests. Investigations into the
      aetiology include a search for bacterial or viral infection but particularly for
      a metabolic cause: especially for hereditary fructose intolerance which may be
      difficult to distinguish from tyrosinosis. Finally, methods of treatment are
      discussed: continuous glucose infusion, exchange transfusion, assisted
      ventilation, and dietary measures beginning with protein exclusion. The
      importance of careful observation is stressed (particularly sequential studies of
      bloodclotting factors).

PMID- 1015981
TI  - [HL-A antigens in dust allergy in children].
AB  - The distribution of 29 HLA antigens has been compared in 60 unrelated children
      presenting a dust allergy and in 300 healthy controls. We observed an increased
      frequency for HLA-Aw19 and HLA-B5 in patients. Yet, the differences are not very
      significant and there is probably no association between one HLA gene and the
      dust allergy.

PMID- 1015982
TI  - [Study of orosomucoid in the newborn. Value in the diagnosis of bacterial
      infections].
AB  - The seromucoid concentration was estimated in 131 newborn infants who were
      divided into four groups (controls, dysmature-postmature, infected,
      miscellaneous). Elevation of seromucoids suggested neonatal bacterial infection.
      The non-specific nature of the elevation is compensated for by the ease and the
      speed of obtaining a result.

PMID- 1015983
TI  - [Acute intermittent porphyria at 4 months of age].
AB  - Acute intermittent porphyria was diagnosed in a child who presented with an acute
      abdomen and neurological signs of the age of four months. The diagnosis was
      confirmed by the absence of uroporphyrinogen synthetase in the erythrocytes. The
      rarity of the disorder at this age is emphasised.

PMID- 1015984
TI  - [Iconographic rubric].

PMID- 1015985
TI  - Transmission and scanning electron microscopy of the human ceruminous apocrine
      gland. I. Secretory glandular cells.
AB  - The secretory portion of the apocrine sweat gland of the human external auditory
      meatus which is also called the ceruminous gland was observed by transmission and
      scanning electron microscopy. The secretory glandular cells contain a well
      developed smooth endoplasmic reticulum and Golgi apparatus. Cisternae of rough
      endoplasmic reticulum are often closely applied to large round mitochondria.
      These large mitochondria have no relationship to the secretory granules. Near the
      concave surface of the Golgi lamellae several tubules can be found. In these
      golgi-associated tubules a dark substance may accumulate to form specific large
      dense granules. Many less dense droplets or vacuoles may appear in these dark
      prosecretory granules and become liberated from their surface. Vacuoles formed in
      this manner then migrate to the apical cell surface and often discharge their
      contents into the gland lumen by the mechanism of exocytosis. Also, some of these
      vacuoles may be released into the lumen by the pinching off of small protrusions
      of cytoplasm, that is, they are released by the so-called apocrine secretory
      mechanism. Acid phosphatase activity was demonstrated not only in the dark
      prosecretory granules but also in clear vacuoles situated at the apical end of
      the cell and in the gland lumen. Such a histochemical finding may indicate that
      the secretory substance of the apocrine sweat gland may contain hydrolytic
      enzymes derived from lysosomes, which are the prosecretory granules of this
      gland, and these enzymes may play a role in dissolution and break down of the
      material extruded into the lumen by apocrine secretion. Apocrine secretory
      process of various sizes were observed on the luminal surface with the scanning
      electron microscope.

PMID- 1015986
TI  - Transmission and scanning electron microscopy of the human ceruminous apocrine
      gland. II. Myoepithelial cells.
AB  - The myoepithelial cells of the human ceruminous apocrine gland were observed with
      transmission and scanning electron microscopes. The myoepithelial cells are long
      fibrous cells about 100-150 mum in length and 3-5 mum in width. They are arranged
      in parallel with each other, and their long axes are parallel to that of the
      secretory tubule itself. The tips of cells are often sharply pointed and their
      lateral tapering surface may be contiguous with adjacent cells forming a side-by
      side contact, while other cells may have a blunt tip which is conjuncted with a
      similar tip of the next cell forming an end-to-end junction. The myoepithelial
      cells are joined to each other by desmosomes and there are also desmosomes at
      their junction with secretory cells. The outer surface of the cell abutting on
      the basal lamina has some exaggerated densities which are undoubtedly identical
      to the hemidesmosomes of epidermal cells. There are well developed foldings in
      the plasma membrane of the secretory cells, but the surface of the myoepithelial
      cells has very few foldings and projections. The relative shortage of
      intercellular attachment devices between the secretory and myeopithelial cells
      makes it easy to peel off the secretory cells to disclose the myoepithelium, a
      useful feature of scanning electron microscopy. The nucleus-containing part of
      the cell protrudes slightly upward and invades the secretory epithelium. The
      cytoplasmic rim surrounding the nucleus contains a small Golgi apparatus and some
      other organelles. The cytoplasm of the basal half of the cell contains closely
      packed myofilaments running parallel to the long axis of the cell. There is no
      definite arrangement of thin and thick myofilaments. Microtubules which often
      occur in pairs are arranged parallel to the myofilaments.

PMID- 1015987
TI  - An electron microscopic study on the innervation in the taste buds of the mouse
      circumvallate papillae.
AB  - Taste buds of the mouse circumvallate papillae were studied by electron
      microscopy to elucidate the innervation involving the adrenergic nerve supply.
      Typical afferent synaptic contacts, with increased density of the membranes and
      aggregations of synaptic vesicles in the cytoplasm adjacent to the nerve endings,
      were demonstrated between the type III cells and the nerve endings. Along the
      regions of contact between the type II cells and the nerve endings, cisternae of
      endoplasmic reticulum were often seen beneath the cell membrane, and the nerve
      endings contained relatively many synaptic-sized vesicles. Such an innervation
      seems to be efferent in nature. For the detection of the adrenergic nerve supply,
      5-hydroxydopamine (5-OH-DA) was injected after pretreatment with L-DOPA and
      nialamide. The mice showed numerous adrenergic nerve fibers in the connective
      tissue underlying the taste buds. On very few occasions, the adrenergic nerves
      penetrated the basal lamina of the taste buds and came into contact with the bud
      cells. Some adrenergic nerves were distributed among the epithelial cells around
      the taste buds. The reaction product from acetylcholine esterase activity was
      found around the adrenergic nerve fibers labeled with 5-OH-DA.

PMID- 1015988
TI  - Microcirculation of the rat small intestine as studied by the injection replica
      scanning electron microscope method.
AB  - Mucosal blood supply in the rat small intestine was studied by the injection
      replica scanning electron microscope method. The blood vascular plexus in the
      villus is originated at the tip of the villus and confluenced near the base of
      the villus. This supports the classical "fountain pattern" of MALL in the villous
      microcirculation. The capillary plexus in the crypt is derived at the base of the
      crypt and converged near the base of the crypt. The capillary plexuses in the
      villus and the crypt communicate with each other. It is considered that the basal
      segment of the villus, where the arterial termination is lacking, is supplied by
      the cryptal capillaries via this communication.

PMID- 1015989
TI  - Scanning electron microscopic study on the saccus vasculosus of the rainbow
      trout.
AB  - Both free and cracked surfaces of the saccus vasculosus in adult rainbow trout
      (Salmo gairdneri) have been investigated by scanning electron microscopy (SEM).
      The saccus vasculosus is the rich-folded epithelium composed of highly
      specialized coronet cells, supporting cells, and presumable liquor-contact
      neurons. The coronet cells are characterized by both numerous specialized cilia,
      so-called "globules" projecting into the saccus lumen and abundant smooth
      endoplasmic reticulum in the cytoplasm. By the appearance of these globules,
      coronet cells are roughly divided into two types: botryoidal coronet cells and
      flower-like. The former is supplied with grape-shaped globules, whose density is
      60-80 pieces a cell. The latter contains club- or petal-shaped globules, which
      number 50-60 pieces a cell. The functional significance of these globules is
      additionally discussed. The free surface of the supporting cells is relatively
      smooth, and short microvilli lie scattered on the surface. The cells called
      liquor-contact neurons (the third type) possess a head-like protrusion where long
      solitary cilia can be recognized.

PMID- 1015990
TI  - Changes in glucoamylase activity under the influence of drugs affecting the
      adrenergic receptors in myocardium and skeletal muscle.
AB  - The activity of neutral glucoamylase and alpha-amylase were determined in the
      myocardium and skeletal muscle after in vivo pharmacologic stimulation of
      adrenergic receptors. The activity changes of these enzymes were found to not
      always occur parallelly. The activity of both these enzymes is decreased under
      beta-agonistic influence of isoprenaline, adrenaline, as well as under the
      influence of acetylcholine. On the other hand, alpha-agonistic function of
      phenylephrine mainly results in the increase of neutral glucoamylase activity.
      Similar effects are obtained by suprarenal ligation. The above pharmacological
      effects did not appear when the said pharmacologic drugs were added to incubated
      muscle extracts.

PMID- 1015991
TI  - Synthesis and pharmacologic properties of pyridoyl derivatives of 3
      methylaminoindole 2-methyltryptamine and isotryptamine.
AB  - Six new pyridoyl derivatives of 3-methylaminoindole, 2-methyltryptamine and
      isotryptamine were synthesized by condensation with chlorides of nicotinic and
      isonicotinic acids. The central action of these compounds seems to depress the
      central nervous system, as they reduce spontaneous motility (I, II, IV, V, VI)
      and amphetamine hypermotility (II, IV, V), prolong hexobarbital sleeping time
      (II, IV, V, VI), display analgesic action in the "writhing test" (all compounds)
      and in the "hot plate test" (IV, V). The compounds do not change body temperature
      and display no anticonvulsant action.

PMID- 1015992
TI  - Search for new aminoguanidine derivatives with immunosuppressive and cytostatic
      properties. II. Synthesis of cyclic derivatives of amino-, nitroamino-, and
      diaminoguanidine.

PMID- 1015993
TI  - Potential acetylcholinesterase reactivators: oxime and amidoxime derivatives.
AB  - Out of 12 oximes and amidoximes (3 of which were new to the literature) the
      following showed a distinct antilethal effect in DFP poisoning: RA14 (1
      methylbenzimidazole-2-aldoxime methiodide), RA14 (pyridine-4-aldoxime dodecyl
      bromide), and RA24 (pyridine-2-aldoxime dodecyl bromide). These compounds also
      reactivated acetylcholinesterase (AChE) in vitro, but had no effect on this
      enzyme in vivo. Moreover, addition of the dodecyl chain to pyridinealdoxtimes, or
      in a less degree replacement of the pyridine ring with benzimidazole in
      aldoximes, distinctly increased acute toxicity and lipophilicity when compared
      with the parent pyridine compounds, along with protective action in DFP
      poisoning.

PMID- 1015994
TI  - Evaluation of the influence of epoxide resins and their hardeners on the female
      body. II. Biochemical studies.
AB  - In women employed in an industrial plant in direct contact with epoxide resins
      and their hardeners, the following biochemical parameters were determined in
      blood: total protein, seromucoid, haptoglobin, hemoglobin variants,
      methemoglobin, alpha1-inhibitor of trypsin, lactate dehydrogenase, aspartate and
      alanine aminotransferases, alkaline and acid phosphatase, gamma-glutamyl
      transpeptidase, leucylaminopeptidase, and alanine aminopeptidase. Depending on
      duration of work, Hb A2 fraction and lactate dehydrogenase increased
      significantly, and aspartate aminotransferase, acid and alkaline phosphatase
      activities decreased. In pregnant women, leucylaminopeptidase activity and
      isozyme of placental alkaline phosphatase were decreased.

PMID- 1015995
TI  - Hydroproteolytic activity of the pancreas after single or fractionated x-ray
      irradiation of rats.
AB  - The enzymic activity of lipase, lysosomal markers (beta-glucuronidase and acid
      phosphatase) and cathepsin was checked in the pancreatic subcellular fraction of
      control and whole-body X-irradiated rats. Incubation of granules (zymogen and
      mitochondrial fraction) under hypoosmotic conditions resulted in greater activity
      of lipase and cathepsin in the irradiated than in the control group. However,
      formation of different pattern of enzymatic activity was found (both in the
      sediments and in the supernatant) in single and fractionated irradiated pancreas.

PMID- 1015996
TI  - [Colloidal, partition and binding properties of phenothiazine derivates, III;
      Influence of hydrotropic compounds on molecular association (author's transl)].

PMID- 1015997
TI  - [Colloidal, partition and binding properties of phenothiazine derivatives. 4.
      Relationships between partition coefficients and association properties].

PMID- 1015998
TI  - [C-5(4) cyclic substituted histamines and N alpha-methylhistamines (author's
      transl)].

PMID- 1015999
TI  - [Thiocyanatochromium(III) complexes with pilocarpine and the analytical
      determination of this alkaloid (author's transl)].

PMID- 1016000
TI  - [Preparation and structure of pyrazolone azomethine dyes (author's transl)].

PMID- 1016001
TI  - [E/Z-isomerism of substituted 4-oximinopyrazolin-5-ones (author's transl)].

PMID- 1016002
TI  - [Methaqualon-like benzothienopyrimidines (author's transl)].

PMID- 1016003
TI  - [Derivatives of 3-aminothieno(2,3-d)pyrimidine and of 3-amino(1)benzothieno(2,3
      d)pyrimidine (author's transl)].

PMID- 1016004
TI  - [Antiviral agents, XI: Nucleophilic substitutions and additions with 2
      aminoadamantane (author's transl)].

PMID- 1016005
TI  - [Reactions of N-alkoxycyclimonium salts. 7. The reactivity of N-methoxypyridinium
      salts with Grignard compounds].

PMID- 1016006
TI  - [Synthesis of 2-methoxycarbomethylidene-1H-perimido(2,1-b)3-thiazolidinone].

PMID- 1016007
TI  - [The reaction of all-cis cyclopentanetetracarboxylic acid dianhdride with
      methylamine].

PMID- 1016008
TI  - [Nucleophile substitltion on the Ar-ring of methoxynitrochromones].

PMID- 1016009
TI  - [Nitrones. 6. Isoxazolidine compounds. 6. Malonic ester addition of nitrones with
      large N-substituents].

PMID- 1016010
TI  - [1,2-cyclization reactions of indole derivatives. 6. The dimerization of 1-methyl
      9-phenyl-3H-pyrrolo(1,2-a)indole-3-one].

PMID- 1016011
TI  - Flashbacks: a personal follow-up.
AB  - During the period 1971-1973, it was found that 53 out of 91 young drug abusers in
      a psychiatric hospital had experienced flashbacks. This applied to as many as 50
      out of the 65 patients who had used LSD, but also to abusers of organic solvents
      and cannabis. As many as 38% of the patients were found to be severely
      incapacitated by their flashbacks. On a personal follow-up 1 1/2-4 years after
      the first therapeutic contact, 35 patients were still troubled by flashbacks. On
      the whole reactions were less intense than at the time of the first contact. No
      relation between the flashbacks and protracted psychotic development could be
      established. The overall clinical and social course was worse for patients with
      flashbacks than for the rest of the population. Patients still bothered by
      flashbacks used drugs and alcohol as sedatives to a greater extent than the rest.

PMID- 1016012
TI  - Restricted associations of aphasics and schizophrenics.
AB  - Matched groups (N = 25) of fluent and nonfluent aphasics, brain-damaged and
      normal controls as well as schizophrenics were requested to name (1) as many
      animals and (2) as many things that are typically yellow as possible within 5
      min. The main results of Gloning & Muller (1972) as to smaller numbers of correct
      responses, higher percentages of repetitions, shorter association clusters, and
      higher popularity in aphasics could be replicated for animal task. Comparing the
      data from both tasks for fluent and nonfluent aphasics with the various control
      groups led to considerable doubts as to what extent these results follow directly
      from quantitative differences in verbal output or have to be interpreted as
      qualitative differences in memory storage, retrieval, and self-editing processes.

PMID- 1016013
TI  - [Dysfunctions of space perception and spatial ability in schizophrenia (author's
      transl)].
AB  - Thirty-seven acute schizophrenics and 25 normal subjects were investigated with
      regard to their spatial perception, representation, and their spatial ability,
      Schizophrenics showed significantly poorer performances (in terms of quantity) in
      those variables, which characterized the ocular apprehension of structures and
      wholes, the relation of parts to a whole, or the analysis of a whole in its
      various components as well as the availability of visual engrams, partly in the
      sense of spatial representation, and the practical realization of imagined
      spatial configurations. On the other hand, in ocular apprehension,
      interpretation, and when necessary the practical realization of two-dimensional
      represented spatial symbols and configurations and perspective abilities there
      was only statistical trend for quantitatively poorer performances in
      schizophrenics compared with healthy persons. Factor analysis of the
      intercorrelation matrices for 14 variables separated out the same 4 factors in
      each group for space perception and spatial ability. In spite of the demonstrated
      "quantitative" differences for the single variables between the two groups a
      marked similarity in a "qualitative" sense was found, when the two-factor
      structures were compared mathematically (similarity coefficient: 0.664). In order
      to specify these differences, 56 schizophrenics were classified as paranoid or
      nonparanoid and investigated in the above-mentioned manner. While these groups
      did not show any significant quantitative difference concerning their
      performances at variable level, they showed entirely different structures using
      factor analysis. Spatial perception of the paranoid schizophrenics seemed less
      structured and their perceptual conception less systematical. On the other hand,
      when factor structures from nonparanoids and healthy controls were compared
      mathematically, both groups showed a marked similarity (0.783). An attempt was
      made to relate these results to other findings of literature and to theories of
      cognitive and perceptual dysfunctions of schizophrenics.

PMID- 1016014
TI  - [Methodologic studies of the Hamilton rating scale for depression (author's
      transl)].
AB  - Within the scope of psychopharmacologic therapies, the Hamilton Rating Scale for
      Depression was applied 3 times on each of 197 psychiatric patients. An extended
      version (24 symptoms) of the Hamilton Scale was employed, which included the
      original symptoms. Various formal analyses (frequency of symptoms, influence of
      sex, item analyses, estimation of reliability, factor analysis) allow the
      following conclusions: With the original version, the single factor solution is
      the most consistent; several factors are not acceptable. With the extended
      version (used in the U.S.A.) the single factor solution can be equally
      recommended, but the two factor solution could also be taken into consideration,
      whereby a distinction is made between retarded depression and somatic depression
      aspects. The total score of the Hamilton Scale is satisfactorily consistent and
      hardly dependent on sex.

PMID- 1016015
TI  - [Comparative investigations of psychoses in parents, children and siblings
      (author's transl)].
AB  - Psychoses in 441 hospital patients from 210 families have been investigated
      comparatively. In 106 families 109 parents and 117 children suffer as do 215
      siblings in 104 families. It has been established that the sexual appurtenance
      does not have a decisive importance in the genetic transmission of the psychoses,
      while comparing the diagnoses, a high percentage (84.5%) of coincidence is
      founded. Similarities appear in the clinical features, in their course, and the
      therapeutical effect. The psychoses begin at an earlier age and are taking a
      heavier course in children, when compared to parents and in the younger brothers
      and sisters when compared to the elder. In couples with different diagnoses, a
      similarity is determined as far as the investigated indices are concerned. The
      clinical features are atypical and symptoms and syndromes, characteristic for the
      different families, are manifested.

PMID- 1016016
TI  - [Visual stabilization of free stance in infants: a sign of maturity (author's
      transl)].
AB  - The development of the visual contribution to postural stabilization has been
      tested using a large visual display rotating around the stationary subject's line
      of sight. This, in the adult, causes a marked optokinetic postural reaction with
      a shift of the body center of gravity toward the direction of pattern motion.
      Scalings of the reactions in children between 6 months and 16 years revealed
      three phases of development: (1) 6--12-month-old-babies show none or very little
      optokinetic disturbance of their newly acquired ability to sit. With the
      development of upright stance and gait, optokinetic influences become
      increasingly important. (2) Children between the age of 2--5 show a marked
      dependence of postural stability on vision. In them, the disturbing optokinetic
      stimulus leads to a marked ipsilateral postural deviation or irresistible fall.
      (3) From 5 to 15 years of age, visual effects on postural balance slowly decrease
      to their final strength in adulthood--moderate head and body tilt--in response to
      the rotating stimulus. It is concluded that the optokinetic loop participates
      rather late in the multisensory process of postural stabilization. The
      calibration of the three main loops, visual, vestibular, and proprioceptive,
      seems to be sequential and mutually interactive. Optimal functioning requires the
      continuous evaluation of the reafferent sensory consequences of self-generated
      body movements. Optokinetic destabilization of stance requires the maturity of
      opto-vestibulo-spinal pathways. Its clinical applicability as a maturity test,
      however, sofar seems limited.

PMID- 1016017
TI  - Effects of selective sleep deprivation on sleep-linked prolactin and growth
      hormone secretion.
AB  - 1. The secretion of prolactin and growth-hormone (hGH) was investigated during
      sleep in 10 healthy volunteers (8 males and 2 females): The comparison of one
      baseline night, one night after daytime physical exercise, and one night with
      selective deprivation of sleep stages 3 and 4 and paradoxical sleep showed clear
      differences of prolactin and hGH secretion during sleep. 2. Prolactin secretion
      is entrained into the sleep cycle of Non-REM and REM periods. A maximum of plasma
      hormone elevations occurs during the first quarter of sleep cycles, i.e., during
      Non-REM periods and less frequent rises at the end of the cycles, mainly during
      REM periods. 3. In contrast to growth hormone, concentrations of prolactin remain
      high also during later cycles occurring toward morning. This shows that high
      prolactin, but not high concentrations of hGH, regularly occur during sleep
      cycles with small amounts of slow-wave sleep. 4. Maximal prolactin concentrations
      during sleep are affected neither by preceding daytime physical exercise nor by
      selective deprivation of slow sleep stages 3 and 4. This is further evidence that
      slow-wave sleep stages are not necessary for the development of high plasma
      prolactin concentrations. However, peak values of growth hormone in the first and
      second cycle are significantly diminished after selective deprivation of sleep
      stages 3 and 4. 5. In abnormally long sleep cycles with artificial delay of the
      first REM period, the cyclical rhythmicity of prolactin release seems disturbed.
      This is further evidence for the sleep-dependent rhythmicity in the secretion of
      this hormone.

PMID- 1016018
TI  - [Concepts of psychiatric diagnoses: a further investigation of the reliability of
      psychiatric diagnoses (author's transl)].
AB  - A total of 128 physicians and psychologists, working in six psychiatric
      hospitals, were asked to allocate 10 psychiatric diagnoses on the basis of
      typical clinical criteria (symptoms, course of illness, etiological and
      anamnestic data), with which they were supplied. The correct diagnosis was made
      in 45.3%, while in 82% the broad diagnostic group was correctly ascribed. The
      respondents were divided into two groups, according to the amount of diagnostic
      data they had been given (though in fact the information necessary for
      differential diagnosis was given equally to both groups). The group which made
      diagnosis on the grounds of more comprehensive data (ten characteristic
      diagnostic items) did significantly worse them the group which had few data (six
      characteristic items). The stereotypes for mania, endogenous depression,
      obsessional-compulsive neurosis, and antisocial personality disorder were
      correctly defined by 75% of more of the respondents. The profiles of the
      remaining six diagnostic groups were associated with the corresponding diagnoses
      by 50% or fewer of the respondents.

PMID- 1016019
TI  - [Autoradiographic investigations in repeated experimental brain concussion
      (author's transl)].
AB  - Single brain concussion in rabbits causes an increased proliferation of glial and
      mesenchymal cells. Repeated experimental concussions in rabbits (3 times at
      intervals of 24 h) led to an increased incorporation of H3-thymidine in glial and
      mesenchymal cells with a maximum at 48 h after the third concussion. This is
      interpreted as an indication of increased cell proliferation. The first and the
      second concussion did not cause a comparable reaction, thus suggesting that
      concussions may inhibit DNA synthesis under the conditions of our experimental
      setup. When the concussions were induced at an interval of 48 h the result was
      different: 48 h after each concussion we found an increase of labeled cells
      compared with the controls. After the second concussion the reaction was still
      more enhanced compared with the reaction following the first concussion. In
      contrast to this the number of labeled cells after the third concussion was
      significantly decreased compared with those after the second one. Parallels with
      pugilistic encephalopathy are discussed.

PMID- 1016020
TI  - Season of birth and Schneider-oriented diagnosis of schizophrenia, "neurosis" and
      psychopathy.
AB  - Most earlier studies and all studies on national samples in Scandinavia and in
      England and Wales have shown that schizophrenics have a significant excess of
      births in the early months of the year when compared with the expected
      distribution of the normal population. The present German study, carried out on
      schizophrenic patients diagnosed in a strongly Kurt Schneider--oriented clinic,
      in contrast to almost all other authors, demonstrated no such significant
      overrepresentation of births in the winter months. Thus, the findings of
      Danneel's (1973) German report, also utilizing Schneider-diagnosed
      schizophrenics, seem, at least for the present, to be confirmed.

PMID- 1016021
TI  - [Clinical observations on the psychopathology of amnesic episodes (transient
      global amnesia) (author's transl)].
AB  - Observations obtained by psychopathologic examination and some psychologic
      testing of two patients in the course of amnesic episodes (transient global
      amnesia) are presented and discussed. In both cases the psychopathologic findings
      are those of a reversible isolated amnesic syndrome, characterized by diffuse
      retrograde amnesia and recent memory deficit, whereas immediate and remote
      (personal) memory are preserved. Stereotype questions, disorientation in time,
      and--in one case--anxious restlessness, which accompany the amnesic syndrome, are
      probably due to impaired memory and the patient's awareness of it. This typical
      syndrome allows differentiation of amnesic episodes from other types of amnesia.
      In the first case, which had been under clinical observation from the beginning
      to the end of the amnesic episode, a special evolution of the event could be
      ascertained. The acute amnesic episode reached its climax with a certain delay
      and thereafter decreased gradually. It can be presumed that--at least during the
      remission phase in the second case--the ability of recall is impaired rather than
      that of registration and retention. Other findings obtained in the second case-
      and compared with observations in the literature--point out that in the phase of
      remission the timespan of retrieval seems to become longer and, in respect to
      previously applied sensory modalities, improves in a different manner.

PMID- 1016022
TI  - [What is missed by Eyseneck's personality inventory (EPI)].

PMID- 1016023
TI  - [Problems in the dependence of AFS-scales on demographic variables].

PMID- 1016024
TI  - ["Good impression" and attitudes. Contribution to the problem of fakeability of
      attitude inventory].

PMID- 1016025
TI  - [Affective evaluation of meaningful acoustic stimuli in wakefulness and its
      influence on sleep behavior. II. Affective evaluation of meaningful acoustic
      signals in wakefulness].

PMID- 1016026
TI  - [Intervention effects in clinical time series].

PMID- 1016027
TI  - [Readiness and selectivity of reaction codes].

PMID- 1016028
TI  - [Clustering, subjective organization and reproduction performance].

PMID- 1016029
TI  - [Appearance of quasiequivalent solutions, in a generalization of the Kruskal
      scale technic, to metric spaces using a Minkowski metric].

PMID- 1016030
TI  - [Centration osteotomy in the prevention and therapy of arthrosis in hip
      dysplasia].

PMID- 1016031
TI  - [Surgical incisions in orthopedics and in tension lines of the skin].

PMID- 1016032
TI  - [Anterior somatotomy of the cervical spine].

PMID- 1016033
TI  - [Preliminary results in the reduction and surgical stabilization of
      spondylolisthesis].

PMID- 1016034
TI  - [Surgical treatment of ulnar nerve compression syndromes at the wrist and of
      simultaneous compressions of the ulnar and median nerve at the wrist].

PMID- 1016035
TI  - [Valgus osteotomy in various forms of secondary arthrosis of the hip].

PMID- 1016036
TI  - [Habitual dislocation of the patella. (Revision of cases treated using the Putti
      Goebbel method) Synopsis of the subject].

PMID- 1016037
TI  - [Luxations and fracture-luxations of the elbow].

PMID- 1016038
TI  - [Therapy of aneurysmatic bone cysts].

PMID- 1016039
TI  - [Association of tuberculous lesions and carcinomatous vertebral metastases].

PMID- 1016041
TI  - [Osteoclast model for the correction of congenital varus-supinatus foot].

PMID- 1016040
TI  - [Surgical correction of a vere case of congenital coxa vara].

PMID- 1016042
TI  - [2-needle cannula for the topical treatment of skeletal lesions].

PMID- 1016043
TI  - [Multiple congenital arthrogryposis].

PMID- 1016044
TI  - [A new apparatus for integral asepsis in surgical interventions: the surgical
      sack. Preliminary report].

PMID- 1016045
TI  - [Total hip prostheses with acrylic cement fixation. Preliminary study of 100
      consecutive Charnley prostheses].

PMID- 1016046
TI  - [Treatment of pelvic obliquity in paralytic scoliosis].

PMID- 1016047
TI  - [Difractometric x-ray study on surgically-removable extra- and para-articular
      calcifications].

PMID- 1016048
TI  - [Topical effect of corticosteroids in microcrystals in various diseases of the
      skeleton].

PMID- 1016049
TI  - [Treatment of recent fractures of the femoral neck and their sequelae in
      childhood and adolescence].

PMID- 1016050
TI  - [Isobutylene diurea as a new source of NPN for ruminants. 1. Nitrogen balance and
      plasma amino acid composition after feeding of isobutylene diurea to sheep].
AB  - The paper first presents a survey of the existing literature where studies on the
      effects of isobutylidene diurea (IBDH) as NPN source for ruminants are discussed.
      Following this the authors discuss their own experiments on IBDH turnover. IBDH
      showed no toxi cation when tested in toxicity studies with rats which were
      carried out under standardized conditions. Within the framework of metabolism
      trial 4 growing male sheep (average liveweight: 30 kg) were fed a semisynthetic
      diet containing IBDH as sole N source. Each animal received 60 g IBDH per day.
      The average value for the apparent N digestibility was found to be 77.6%, the
      percentage for the average N ballance was 27.6%. The blood of the sheep was
      investigated, on a comparative basis, for the behaviour of free amino acids after
      the administration of an experimental semisynthetic diet containing IBDH or
      extracted soya bean meal as sole N source. The use of IBDH produced a higher
      concentration of free amino acids and a five-fold increase if urea concentrations
      in the blood plasma but reduced the Asp, Cys and Tyr levels when compared with
      the feeding of extracted soya bean meal. Similarly, IBDH supplementation
      increased the relative proportions of Gly, Lys, and His in blood plasma but
      reduced those of Asp, Val and Tyr. A positive relationship between the rate of
      IBDH hydrolysis and the decrease in pH was found in experiments studying the
      hydrolysis behaviour of IBDH at pH values from 1-7.

PMID- 1016051
TI  - [Histological studies on cow intestinal mucosa and electron microscopic studies
      of the ruminal epithelium of cows fed a deficient diet for a prolonged time].
AB  - Histological and histochemical studies were carried out on the gastro-intestinal
      mucosa of three experimental cows (roughages/maize silage) and three control
      animals. The animals were slaughtered on termination of the long-term trial.
      Mucosa samples were taken, for further study, from the rumen, the duodenum, the
      jejunum, the large intestine and the appendix. Histochemical analysis did not
      reveal any essential differences in the activities of non-specific esterase,
      alkaline and acid phosphatase and lactic acid dehydrogenase in the mucosa of the
      rumen, the large and the small intestine and the appendix of both the
      experimental animals and the controls. The experimental animals were found to
      exhibit a higher rate of glutamate-dehydrogenase activity in the ruminal mucosa
      and in the mucosa of the large and small intestine. A higher succinate
      dehydrogenase activity was observed in the ruminal mucosa of the experimental
      animals, relative to that of the controls, while the activity in the intestinal
      mucosa was decreased. Only slight changes were noted in the activity of the
      enzymatic systems tested. Electron microscopic studies did not reveal any
      differences in the ultrastructure of the epithelial cells of the ruminal mucosa
      in both the experimental animal and the controls.

PMID- 1016052
TI  - [Excessive oral administration of iron to sheep. 1. Digestibility of rations,
      results of fattening and carcass yields].
AB  - 4 digestibility trials (4 male sheep per group) and 2 growth trials were carried
      out with 24 (V 1) and 32 (V 2) fattening lambs to investigate the effect of
      abundant oral Fe doses on the digestibility of crude nutrients in a ration of
      barley + dried green feed and on the results of fattening and carcass yields. Fe
      supplementation (less than 1400 mg per sheep/day) did not significantly change
      the digestibility coefficients of crude nutrients. Increasing Fe levels in the
      concentrates decreased the rates of liveweight increase and food consumption in
      both growth trials. Well-established statistical evidence was provided for the
      decline in absolute carcass yields resulting from the lower weight of the lambs
      at the end of the fattening period after Fe supplementation.

PMID- 1016053
TI  - [Nickel content in the milk of lactating rats under intake of various amounts of
      nickel].
AB  - Model experiments were carried out with rats showing that the average Ni
      concentrations in the milk of the experimental animals receiving a Ni deficient
      diet (40 ppb of dietary Ni), relative to those of the controls (20 ppm), declined
      from 1088 ng/g to 726 ng/g (33%). This produced a Ni deficiency in the youngs of
      the rats resulting in retarded growth, reduced Fe absorption and a decline in
      enzymatic activity. An increase in the Ni content of the milk from both the
      experimental animals and the controls was observed during lactation. In the Ni
      deficient group this upward trend was longer noticeable from about the middle of
      the lactation period onwards. Animals in the Ni deficient group excreted about
      three times as much Ni through the milk as was ingested with the food. Because of
      the wide range of deviations of the Ni content in the different animals the Ni
      content of the milk cannot be used, under practical conditions, as an index of a
      state of Ni deficiency.

PMID- 1016054
TI  - [The problem of the use of urea in feeding swine].
AB  - For a period of 9 days growing fattening pigs (with liveweights ranging from 40
      to 50 kgs were fed a ration of autumn barley, dried skim mild and wheat gluten
      supplemented with 0.5% of 15N labelled urea (12.5% of the total N). The N balance
      and the rate of 15N protein retention as well as the rates of protein and amino
      acid synthesis in the different organs and tissues of the carcasses were
      estimated by emission spectrometry after amino acid fractionation. On an average,
      19.3% of the ingested urea were retained, while only 4% N were retained in the
      essential amino acids found in the carcasses. This proportion will, to a large
      extent, result from transamination processes and, to a lesser extent, from
      microbia synthesis. From this it may be concluded that urea N does not induce any
      appreciable synthesis of amino acids in pigs so that urea cannot be regarded as a
      suitable substitute for protein feeds in the feeding of monogastric animals.

PMID- 1016055
TI  - [The substitution of lysine supplemented high protein wheat for protein feeds
      during the rearing and laying periods of hens. 8. Nitrogen excretion and true
      amino acid digestibility as an effect of various lysine levels and successive
      laying periods].
AB  - Digestibility trials were performed with laying hens receiving 3 types of rations
      containing equal proportions of the same dietary components. The percentage of
      high-protein wheat in these rations was 74%. Ration I was supplemented with 0.12%
      lysine while 0.06% lysine was added to ration II; ration III remained
      unsupplemented. The crude protein content of rations 1 to 3 was 16.1%, 16.5% and
      16.6%, respectively. The corresponding lysine percentages were 0.66, 0.62 and
      0.56. Studies were made to investigate the influence of different lysine levels
      on the rate of N excretion and various amino acid data. These studies were
      carried out during two successive laying periods. Only random differences between
      the data for urinary N excretion and N balances per kg liveweight were obtained
      in the two laying periods and for the different lysine levels. The true lysine
      digestibility was significantly lower in the poor-lysine ration as compared with
      the ration with 0.66% lysine. Moreover, the absorptive capacity for thio-amino
      acids is influenced by the lysine level of the ration. The proportion of lysine
      contained in faecal crude protein increased with the decreasing lysine content of
      the ration. Similarly, the total number of amino acids present in faecal crude
      protein increased with the declining supply of lysine. These findings suggest
      that relatively more NPN compounds are excreted in the faeces if adequate amounts
      of amino acids are supplied rather than when one amino acid is deficient.

PMID- 1016056
TI  - [The substitution of protein feed by lysine supplemented high protein wheat
      during the rearing and laying period in hens. 9. True amino acid digestibility of
      rations with varying lysine levels in hens who had a colostomy].
AB  - 24 experimental birds were fed the same basal ration containing 74% high-protein
      wheat, 4% extracted soya bean meal, 7% extracted groundnut meal, 2% feed yeast,
      1.75% dried green meal, 1.25% mixed vitamins and 10% of a mineral mixture. The
      birds were placed in 4 groups each comprising 6 hens. The first two groups
      received an optimum of lysine (0.68%) added to the ration. The rations for the
      two other groups contained 0.55% lysine. 6 birds of each group receiving either
      the lysinesupplemented or the unsupplemented rations were colostomated to
      investigate in which way the hydrolysed urine would affect the true amino acid
      digestibility. 8.3% of urinary N from the total amount of faecal N were
      precipitated as uranyl acetate in the faeces of hens fed the lysine-supplemented
      ration as compared with 7.3% urinary N in birds receiving the unsupplemented
      ration. The corresponding figures for non-precipitable faecal N were 8.9% and
      8.2%. A comparison was made between the levels of amino acids excreted by
      colostomated and non-colostomated hens showing that 12.4% +/- 3% and 11.7% +/- 3%
      more amino acids (figures for the supplemented and unsupplemented rations) were
      excreted in the presence of urine. On the basis of these results the authors
      recommend that only colostomated hens should be used in digestibility and total
      metabolism trials.

PMID- 1016057
TI  - [Studies on methods for the determination of amino acid requirements for
      metabolic balance based on the oxidation rate of 14C labeled lysine to 14CO2].
AB  - Male experimental rats (100 gm liveweight) were distributed into 10 groups of 8
      animals each and received balanced diets, with the exception of lysine which was
      added to the diets in graded amounts in such a way that the lysine content of the
      diets ranged from 2.44 to 5.92 gm/16 gm N. After a feeding period of 7 days the
      animals received 3H- and 14C lysine injected intraperitoneally, 4 animals of each
      group were investigated for the total CO2 excretion and 14CO2 excretion during
      the first 2 hrs after the injection and for the urinary excretion of
      radioactivity (48 hours). The remaining animals in each group were used for
      determining the plasma amino acids and for establishing the specific
      radioactivity of free lysine in the liver and muscles after an 1-hour
      incorporation period. Total CO2 excretion was not found to be influenced by the
      lysine contents while the level of excretion of 14C activity through CO2 and that
      of specific 14C activity of CO2 increased with increasing lysine concentrations.
      This produced a broken curve pattern, showing an increased release of 14CO2
      (under maintenance conditions) if the diet contained 4 gm lysine/16 gm N and
      more. Investigations for the specific 14C activity of free lysine in the liver,
      the main site of lysine oxidation, showed that the increase in 14CO2 release was
      due to an enhanced rate of lysine catabolism and was not brought about by changes
      in the pool volume or in specific radioactivity. The levels of urinary 14C
      excretion were not found to be related to the lysine content of the diets,
      whereas the curve pattern of 3H excretion observed 5 to 8 hrs after injection was
      similar to that of 14CO2 excretion. The lysine content of blood plasma and the
      content of free lysine in the liver increased continuously with increasing levels
      of dietary lysine. The methodological studies made in the present paper showed
      that in scientific research a determination of amino acid requirements on the
      basis of CO2 oxidation data may be a very exact and sensitive method. It will
      also yield values for maintenance requirements.

PMID- 1016058
TI  - [Studies on the true amino acid digestibility in pigs of various wheat varieties
      from the Soviet Union].
AB  - Studies were carried out with pigs for determining, with classical methods, the
      true digestibility of amino acids contained in 5 intensively grown wheat
      varieties imported from the Soviet Union and in one wheat variety grown in the
      GDR. Of all the varieties tested the variety Mironovskaya 808 exhibited the best
      characteristics. An extremely low true lysine digestibility was established for
      the variety Avrora (68%). If this variety is to be more extensively grown and
      used for feeding purposes further studies will have to be made to see whether
      this low lysine digestibility is really characteristic of this variety.

PMID- 1016059
TI  - [The effect of addition of formic acid to the rations on the energy metabolism of
      sheep and young bulls].
AB  - Total metabolism trials were carried out with 8 fattening bulls and 4 male sheep
      receiving rations supplemented with formic acid. Comparative trials were
      performed with lucerne conservates. The following results were obtained: Formic
      acid supplements of up to 0.7 gm/kg liveweight per animal/day did not influence
      the ruminal fermentation and the digestibility of the food beyond ordinary
      dissimilation processes nor did they influence the energy turnover in the
      animals. Already in the rumen, the added HCOOH was largely broken down into CO2
      and CH4. Higher levels of N retention were observed if the animals were fed fresh
      lucerne silage supplemented with formic acid as compared with dried green feed
      and the other types of silage.

PMID- 1016060
TI  - [The protozoa population in the rumen of fattening bulls fed varying feed and the
      effect of artificial transfer of protozoa].
AB  - High protozoa concentrations were found in the ruminal fluid of fattening bulls
      weighing 400 kg which were raised for the first five months of age in a large
      size calf-raising plant. The ruminal fluid of these bulls, however, contained no
      protozoa of the group Holotricha. If the animals were fed a mixture of
      concentrates and pelleted straw (pH 6, 12.5 mMole of volatile fatty acids per 100
      ml) 1 ml of the ruminal fluid was found to contain 827,000 protozoa whereas if
      the animals received rations rich in concentrates (pH 5.8, 14 mMole of volatile
      fatty acids) 1 ml of ruminal fluid contained only 578,000. Through protozoa
      transfer carried out by infusing 41 of a mixture of ruminal fluid from other cows
      per animal it was possible to settle other species, viz. Isotricha, Dasytricha
      and Ophryoscolex; this, in turn, produced a concomitant decrease in the number of
      Entodinium and a noticeable decline in the total protozoa population. Further
      work will be necessary to find out whether it would be advisable to influence the
      protozoa population of growing cattle kept in large-size cow plants in similar
      ways as described above.

PMID- 1016061
TI  - [The effect of straw in ground and pelleted form on the rumen fermentation and
      protozoa].
AB  - Cows possessing a large ruminal fistula were fed straw meal and pelleted wheat
      straw to investigate its effect on ruminal fermentation (concentration of NH3 and
      volatile fatty acids (FFS), pH, molar proportions of FFS, rates of FFS
      production) and on the protozoa population. The straw-concentrate mixture used in
      the present trial contained 40% of straw. The feeding of pelleted straw produced
      a significant rise in FFS concentrations (from 8.8. to 12.3 mMole/100 ml) and a
      corresponding decline of pH (from 6.7 to 6.1). With high molar proportions of
      acetate (72 mole%) the influence of the straw diet on molar FFS proportions was
      low. The NH3 peak observed 1 hr after feeding was higher with the pelleted straw
      than with the straw meal. The feeding of finely gound straw produced a higher
      level of FFS production (by 10%) than that of straw pellets. (3.88 and 4.29 mMole
      per gm DM). The number of protozoa (per ml of ruminal fluid) was 335,000 (straw
      meal) and 121,833 (pellets). The number of large infusorial cells (Isotricha,
      Diplodinium, Ophryoscolex) decreased correspondingly from 70,000 (straw meal) to
      18,870 per ml (pellets). These results suggest that the feeding of pelleted straw
      concentrate mixtures to cows as sole feed will not bring about optimum conditions
      for ruminal fermentation (FFS formation, protein synthesis) and for the layering
      of ruminal contents.

PMID- 1016062
TI  - [Protein utilization of mixed feed rations in the lactating pig with reference to
      the essential amino acid content of the feed proteins. 1. Report. Description of
      the study methods for protein utilization in the use of peanut extraction
      residues and dry skim milk in the ration].
AB  - A method is discussed which has been used to investigate protein utilization in
      lactating sows. Two N balance trials were carried out to establish the degree of
      protein utilization of mixed feed rations. The rations contained barley, oats and
      flaked potatoes. Extracted pea nut meal or, for comparison, dried skim milk, were
      added as protein sources. The average biological value achieved was 42% if
      extracted pea nut meal was fed and 59% if dried skim milk was added. The
      corresponding PPV data were 33% for the rations containing extracted pea nut meal
      and 49% for the dried skim milk rations. Balances made for the rate of dietary
      amino acid intake and amino acid excretion in the milk showed that lysine
      deficiency occurred when rations were fed containing the extracted pea nut meal.

PMID- 1016063
TI  - [The effect of proteinase inhibitors in rats. 1. Report. Effect of a short-term
      application on the N balance, the free amino acids in liver and muscles and the
      biological half-life of the intestinal tissue proteins].
AB  - Short-term trials with a triazin derivative and a peptide aldehyde were carried
      out to investigate the in-vivo administration of proteinase inhibitors in rats
      for improving the N balance of the animals. The results of N balances suggest
      that the peptide aldehyde may be regarded as a promising substance that may be
      used to increase the rate of utilization of the absorbed N in the intermediary
      metabolism. The short-term use of both active compounds did not affect the true N
      digestibility. The two compounds did not influence the concentration of free
      amino acids in the liver and muscle tissue under the experimental feeding
      conditions used. Similarly, tests of the biological half-life of proteins taken
      from the small and large intestine did not reveal any changes due to the presence
      of the inhibitors. Animals receiving a protein-free diet exhibited longer half
      life periods for proteins from the small and large intestine compared with
      animals of the other groups. A protein-free nutrition of the animals caused a
      general increase in the levels of free non-essential amino acids in the liver.
      This was accompanied by a simultaneous decrease in essential amino acids. The
      same type of nutrition led to a general decline in the concentration of free
      amino acids in muscular tissue, particularly of the essential amino acids. High
      protein nutrition led especially to an increase in the concentration of branched
      chain amino acids in both types of tissues investigated.

PMID- 1016064
TI  - [The nitrogen metabolism of broiler chickens with 15N-labeled wheat. 2. Report.
      15N concentration in the gastrointestinal tract and its contents].
AB  - 17 broilers received a wheat-soya bean meal-pea nut ration containing an excess
      of 15N atom% (6.54%). The birds were slaughtered 3, 6, 12, 36, 60 and 108 hours
      after the last 15N'-intake. Up to 12 hrs after slaughtering the contents of the
      crop and the stomachs were found to contain a higher excess of 15N atom% than the
      food. The contents of the small intestine at that time contained only 1/4 of the
      15N concentration present in the crop and the stomachs (2.7%). Later on the
      excess of 15N atom% decreased to 1.7%, 1.4% and 0.8% and was 4 times as high as
      that found in the crop and the stomach. Higher 15N' concentrations, compared with
      those in the small intestine, were found in the contents of the caecum, the
      colon, and the rectum, for a period of up to 12 hrs after administration of the
      last portion of labelled food. The 15N' concentrations in the crop and the
      stomachs are due to a more prolonged storage of wheat relative to that of the
      extracted meals. The interrelationship between the contents of the small
      intestine and the contents of the higher sections of the gastro-intestinal tract
      suggests that a secretion of N-containing substances takes place, although it was
      not possible to determine these substances quantitatively. Values for the excess
      of 15N atom% in the crop and oesophagus and in the muscular stomach were found to
      be in close correspondence both with regard to their level and time pattern. The
      decline in the glandular stomach was more rapid than in the muscular stomach. A
      very close correlation (r=0.99) was found between the 15N atom% in the contents
      of the intestine and in the intestinal wall. The N content of the small intestine
      (expressed as mg) was significantly higher after 3 hrs and 6 hrs of fasting than
      after a fasting period of 12 hours. Theoretical aspects of the involvement of the
      intestine in the process of metabolism are discussed in some detail.

PMID- 1016065
TI  - Study of the lymphocyte in vitro response to rubella antigen and
      phytohemagglutinin by a whole blood method.
AB  - A whole blood culture method was used to study lymphocyte in vitro responses to
      rubella antigen and to phytohemagglutinin (PHA) in rubella infection. The acute
      phase of infection in four cases was characterized by high spontaneous
      incorporation of 14C-thymidine in the cultures, unresponsiveness of lymphocytes
      to rubella antigen, and absence of response, or relatively low response, to PHA.
      Cells showing vigorous in vitro response to rubella antigen appeared at about two
      weeks after the onset of rash. Lymphocyte PHA response returned to normal by day
      31. Three rubella vaccinees exhibited a similar response. The use of whole blood
      lymphocyte cultures stimulated with multiple doses of mitogen and with antigen
      appears to be a promising technique for studies of "general" and "specific" cell
      mediated immunity in viral infections.

PMID- 1016066
TI  - [Epidemiological study of chronic symptoms of upper and lower respiratory
      airways].

PMID- 1016067
TI  - The fate of pesticides in aquatic environment. II. Hydrolysis of dichlorvos in a
      model system and in river water.

PMID- 1016068
TI  - [Occupational exposure to carbon monoxide in steel mill of converter type].

PMID- 1016069
TI  - [Problems and symptoms of dependence in the exposure to trichloroethylene].

PMID- 1016070
TI  - [Effects of pesticides on eye and vision].

PMID- 1016071
TI  - [Biologically active amantadine derivatives].

PMID- 1016072
TI  - Pneumatosis cystoides intestinalis associated with jejunoileo bypass. A case
      report.

PMID- 1016073
TI  - Nuclear medicine.

PMID- 1016074
TI  - Radiology case of the month. Case no. 17.

PMID- 1016075
TI  - The Arizona Maternal Mortality Committee.

PMID- 1016076
TI  - Hairy women or hirsute patient?

PMID- 1016077
TI  - Pemphigus -- a review.

PMID- 1016078
TI  - [Problems of pathomorphology of generalized Sanarelli-Shwartzman phenomenon in
      endotoxic shock].
AB  - On the basis of 52 sectional observation on post-delivery and post-abortion
      complications the clinico-morphological picture of endotoxin shock, which
      proceeded according to the type of the generalized phenomenon of Sanarelli
      Schwartzmann, is discussed. The condition was characterized by an acute onset,
      signs of shock with a drop of arterial pressure, the hemorrhagic syndrome.
      Morphologically, disorder of the microcirculation was observed: hyperemia, stases
      in many organs, disseminated microthrombosis in capillaries. The thrombosis was
      complicated by origination of necroses of the adrenal cortex and adrenals,
      hypophysis, by ulcers in the stomach and intestine. The "coagulopathy of
      consumption" was the cause of appearing multiple hemorrhages and bleedings.

PMID- 1016079
TI  - [Acute renal insufficiency in exogenous poisoning (problems of classification and
      pathogenesis)].
AB  - Acute renal insufficiency (ARI) -- one of the most frequent manifestations of
      many exogenous intoxications. On the ground of a morphological investigation of
      625 kidneys in poisoning with various poisons, the authors have come to the
      conclusion that the acute nephrotic syndrome is the basis of ARI in a "toxic"
      kidney". A morphological classification of the nephrotic syndrome is given:
      necrotic nephrosis hydropic nephrosis (glycolic nephrosis), cortical necrosis of
      the kidney, excretory nephrosis, acute lipid nephrosis. Morphological
      characteristics of the nephrotic syndrome forms referred to above are presented.
      Lesions of the kidney in exogenous intoxications are caused first of all by the
      direct toxic action of a poison. Toxic shock is an important factor in the
      development of ARI.

PMID- 1016080
TI  - [Desmoid tumors and their mitotic system (morphological diagnosis and problems of
      prognosis)].
AB  - Results of histological studies of desmoid tumours of various localisation and
      determination of their mitotic regimen are presented. the mitotic regimen of
      nonrelapsing desmoids is characterized by an extremely low mitotic index (on the
      average 0.9 mitosis per 1000 cells), a normal ratio of phases of mitosis and by
      the presence of only individual pathological mitoses. In the group of relapsing
      desmoids the mitotic index on the average is 2.4%; the analysis of the percentage
      ratio of mitosis phases reveals predominance of metaphases, the frequency of
      pathological mitoses being increased. These changes apparently reflect the trend
      of these tumours towards the unlimited growth, which is confirmed by their
      clinical course.

PMID- 1016081
TI  - [Topography of changes in the mucosa of the gastro-duodenal region in chronic
      gastritis and peptic ulcer].
AB  - Topographic studies of 789 gastro- and duodenobiopsies obtained from 493 patients
      with chronic gastritis and peptic ulcer and from 37 individuals without gastro
      duodenal pathology obtained various regions of the stomach and the duodenum were
      carried out. It was found out that investigation of only one piece of the tissue
      not in all cases reflected a histological state of the mucosa of the certain
      regions of the gastro-duodenal area. An isolated gastritis in the body of the
      stomach in patients with chronic gastritis was found to occur 3 times as seldom
      as in its distal region. The mucosa of the duodenum was affected almost equally
      often both in peptic ulcer of this organ and in chronic gastritis. In a number of
      patients the clinical picture diagnosed as chronic gastritis in reality turned
      out to be caused by morphological changes in the mucosa of the duodenum, but not
      of the stomach. At the same time, in a duodenal localization of ulcer not
      infrequently there were observed histological changes in the gastric mucosa
      aggravating the course of the main pathological process.

PMID- 1016082
TI  - [Cryptococcosis of appendiceal mucocele].

PMID- 1016083
TI  - [Determination of density, circumference, thickness of the wall and volume of the
      vascular bed of the aorta].

PMID- 1016084
TI  - [Morphological diagnosis of renal cell carcinoma. Histo-cytological parallels].
AB  - A detailed parallel histo-cytological investigation of 100 observations on renal
      cell carcinoma showed that these tumours had a various macro- and microscopic
      structure. For the substantiation of correct diagnosis material should be taken
      from several places of the tumour of different microscopic structure. In
      diagnosis all detected variants of the structure of the tumour and the degree of
      cellular anaplasia should be mentioned. A clear-cell variant in the pure form was
      revealed in 52% of cases, other one-type variants were very rare (7%). In tumours
      of a mixed structure (41%) there were observed various combinations of all the
      variants occurring in the order: clear-cell, granular-cell, sarcoma-like,
      glandular. Collation of Histological and cytological data showed that in the
      overwhelming majority of cases (97%) there was a complete coincidence in
      determination of the morphological type of renal cell carcinoma.

PMID- 1016085
TI  - [Dermatofibrosarcoma protuberans].
AB  - Observations were conducted on 26 patients with protruding dermatofibrosarcoma of
      the skin. Histological and histochemical characteristics, as well as the mitotic
      regimen of these tumours, were investigated. Protruding dermatofibrosarcoma is a
      fibroblastic tumour characterized by a slow growth, usually a big size,
      persistent multiple reoccurrence, late metastases into the lymphatic nodes and
      lungs. No regularities concerning periods and frequency of developing of
      reoccurrences could be established. Clinico-anatomical collations failed to show
      correlation between the mitotic activity of dermatofibrosarcomas and the degree
      of their malignancy and rate of growth of the tumour.

PMID- 1016086
TI  - [Enzymohistochemical and immunomorphological study of experimental thyroid gland
      carcinoma].
AB  - A total of 8 medullary carcinimas, 134 adenomas of C-cells, 32 solid focal over
      growths of C-cells, and 124 normal thyroid glands of rats were investigated by
      histochemical, immunomorphological and histological methods. Modullary carcinomas
      were characterized by a high enzymes of hydrolysis of ethers of carboxylic acids,
      tissue respiration, and by a moderate or low activity of enzymes of the initial
      link of glycolysis, oxidative deamination, synthesis of amino acids, hydrolysis
      of monoethers of orthophosphoric acid, pentose and citric acid cycles. In
      medullary carcinomas, as well as in normal C-cells and adenomas of C-cells, there
      was revealed the phenomenon of occult metachromasia with the absence of a
      microsomal tissue-specific antigen and direct reaction to amyloid. The authors
      consider medullary carcinomas to be analogues of solid carcinoma with amyloidosis
      of the stroma of the human thyroid gland, differing from the latter by specific
      metabolic reactions, and therefore, they may serve as an experimental model in
      studies of these diseases.

PMID- 1016087
TI  - [Histochemical characteristics of mast cells in hemangiomas].
AB  - Mast cells of hemangiomas localized in the skin and in the mucous membrane of the
      oral cavity, have a similar histochemical characteristics of protein and
      carbohydrate components. The histochemical characteristics of the carbohydrate
      component indicate either a high (as compared with the norm) degree of sulfating
      of heparin molecules, or quantitative accumulation of its molecules in the mast
      cells cytoplasm. Moreover, in mast cells there were revealed protein and a
      neutral carbohydrate component. An assumption is put forward that histochemical
      changes in mast cells in hemangiomas were of compensatory-adaptive character and
      were directed to prevent the thrombogenesis in hemangiomas.

PMID- 1016088
TI  - [Vascular changes in genesis of necrotic and inflammatory lesions of the lungs in
      Wegener's granulomatosis].
AB  - Clinico-morphological and histochemical studies of changes in the lungs were
      carried out in 15 fatal cases of Wegner's granulomatosis. Morphological
      manifestations of the lesions consisted in bilateral extensive destructive
      productive panangiitis in the system of bronchial, was well as pulmonary arteries
      and veins. As a rule, there developed an extremely polymorphic granular tissue
      which subsequently underwent necrosis with resulting cavern formation. Deep and
      sometimes irreversible changes observed in the vessels of the microcirculatory
      bed led to alveolar-capillary blockade and hypoxia, the latter culminating with
      circulatory crisis. Drastic dyscirculatory disorders were complicated with auto-
      and superinfection: development of destructive-suppurative bronchitis,
      peribronchitis, interstitial and also confluent pneumonia with "motley" exudate
      in alveoli, not infrequently with an abscess formation, sometimes with formation
      of hyaline membranes. The whole complex of these changes play a significant part
      in pathogenesis of pulmonary-cardiac insufficiency occurring in the majority of
      patients with Wegener's granulomatosis and often is responsible for fatal
      outcomes.

PMID- 1016089
TI  - [Carcinosarcoma of the larynx].
AB  - Sometimes in the larynx tumours develop having the structure of carcinosarcoma
      and growing in the form polyp. Histologically they consist of squamous-cell
      carcinoma and sarcomatous stroma. An observation in which contrary to the cases
      described earlier, the tumour consisted not of two, but of three tumour
      components, is discussed.

PMID- 1016090
TI  - [Possibilities of studying 3-dimensional structure of the arterial wall with help
      of scanning electron microscope].
AB  - A complex of methods for investigation of the architectonics of the vascular wall
      is suggested. It was established that an elastin carcass of all the layers of the
      arterial wall was formed of laminar membranes consisting of cylindrical elastic
      fibers with a diameter 1.5--3 mcm having a fibrillar structure. The window-like
      structure of the laminas was due to separation of bibers. In the laminar
      membranes of the intima and media, including internal ones, elastic fibers had
      circular, and in adventitia--longitudinal distribution, which ensured radial and
      longitudinal elasticity of the wall of arteries. Smooth muscle cells, that had
      spiral orientation, were attached with their ends to the adjacent membranes thus
      regulating their tonus. They are surrounded with elastic and collagenous
      fibrillas, which cover also membranes and connect all the layers of the wall of
      arteries into one morpho-functional system with a high structural stability and
      plasticity.

PMID- 1016091
TI  - [Nature of diverse molecular diseases in man].
AB  - The article comprises the literature data on a new group of enzymopathies in man
      associated with the defect of the cell reparative mechanisms, which in the norm
      restore damages of DNA induced by factors of a different character. Special
      attention is paid to molecular processes observed in the hereditary disease in
      man--xeroderma characterized by a high sensitivity of the patient to ultraviolet
      irradiation and by a high incidence of cancer of the skin. Experimental evidences
      are presented testifying to an elevated sensitivity of cells of such patients to
      carcinogens, some viruses, and illustrating peculiar features of formation of
      structural mutations of chromosomes induced by physical, chemical and biological
      agents. Defects of individual enzymes of reparation in progeria, Fanconi's anemia
      and some other human diseases are described. The author recommends to simulate
      defects of reparative enzymes on diploid human cells infected with the virus of
      leukemia.

PMID- 1016092
TI  - [Morphologic changes in the parathyroid glands in primary hyperparathyroidism].
AB  - On the basis of studies of the histological structure of 7 parathyreoadenomas
      removed in connection with primary hyperparathyroidism three types of their
      structure (trabecular, acinose, and solid) were singled out. As to their cellular
      composition, the adenomas could be divided into clear-cell and dark-cell adenomas
      (of main cells), oxyphilic adenomas, and adenomas of C-cells. The same cells
      (predominantly main clear cells) were found in the 9 studied hyperplastic
      parathyroid glands. Certain differences between the ultrastructure of cells of
      parathyreoadenomas and that of the hyperplastic parathyroid glands were
      established.

PMID- 1016093
TI  - [Dynamics of necrotic changes in skeletal muscle in the prolonged crush
      syndrome].
AB  - Forms, dynamics of and relationships between necrotic changes in the skeletal
      muscles in the early period of the crush syndrome, following 9-hour compression
      of the soft tissue of the dog's thigh and 2 -- 7 hours after removal of the press
      are considered. Two interdependent forms of necrosis of muscles have been
      established -- diskoid and coagulative. Electron-microscopy studies showed that
      discoid necrosis of muscular fibres began with the lysis of the myofilaments of
      isotropic disks and Z-strips with subsequent destruction of myofibrils and
      outcome into myolosis. The peculiar feature of this form of necrosis was nearly
      complete absence of lysosomes. In a light microscope discoid necrosis was
      revealed as clear-cut transversed streaky fibres. Morphologically, coagulation
      necrosis was manifested on the ultrastructural level by formation of myofilic
      conglomerates consisting of overcontracted myofibrils, these being subjected to
      gradual fragmentation and splitting by hydrolases of leukocytes and macrophages.
      Discoid necrosis predominated in the muscles prior to the removal of the press
      and apparently developed because of ischemia. Coagulation necrosis of myofibrils
      was observed mostly following re-vascularization and might be one of outcomes of
      discoid necrosis.

PMID- 1016094
TI  - [Pathomorphology of the nervous system in beta-thalassemia major].
AB  - Pathomorphology of symmetrical areas of various departments of the central
      nervous system was studied in 8 children aged 3--8 years who had died of beta
      thalassaemia major. In 5 patients transient cerebral vascular disorders occurred
      against the background of hemolytic crisis, in 2 -- phenomena of
      polyradiculoneuritis, in 1 -- spinal desorders with lower flaccid paraparesis.
      Vessles were found to be damaged by the pathological process first. Impairment of
      permeability of vascular membranes, hemorrhages and edema of the brain substance
      were observed. As to neurons lesions, along with normal neurons there were nerve
      cells with reactive and dystrophic changes. In pulpous nerve fibres periaxonal
      alterations and Wallerian degeneration predominated. The combination of the
      erythroblastic process with secondary impairment of the metabolism, toxicosis,
      hypoxaemia contributed to the mixed character of the morphological changes, which
      accounted for the polymorphism of neurological symptoms.

PMID- 1016095
TI  - [Morphology and pathogenesis of peritonitogenic pancreatitis].
AB  - Morphological studies of the pancreas in patients who had died of peritonitis at
      various periods of its development were carried out. Moreover, an experiment was
      fulfiled on reproducing peritonitis on 41 dogs. In the pancreas in all sectional
      observations there was observed a picture of acute inflammatory process of a
      various degree of intensity (peritonitogenic pancreatitis) depending upon the
      form of peritonitis. It was established that in pathogenesis of acute
      peritonitogenic pancreatitis an important role was played by direct transfer of
      the inflammatory process to the tissue of the gland on the side of the abdominal
      cavity. At the same time, of great importance were also regurgitation of the
      intestinal content into the system of the excretory ducts of the gland and
      hemodynamic disorders. The morphological picture of the reproduced in the
      experiment on dogs acute peritonitogenic pancreatitis was similar to that in the
      section observations. Both sectional and experimental data confirm the duct
      enzymatic theory, or the theory of "common canal", of the pathogenesis of
      pancreatitis in general of and peritonitogenic pancreatitis in particular.

PMID- 1016096
TI  - [So-called empty liver cell nuclei in hepato-cerebral dystrophy and other
      diseases].
AB  - The frequency of identification of "empty" nuclei of hepatocytes was investigated
      in 65 patients (25 patients with hepato-cerebral dystrophy, 18 patients with
      cirrhosis of the liver, 15 patients with chronic diseases of the extrapyramidal
      nervous system and other diseases) with the help of fluorescent and electron
      microscopy, cytophotometric determination of DNA, and on the basks of bioptic
      material (in 60 patients) and autopsy findings (in 5 cases). The so-called
      "empty" nuclei of hepatocytes are not specific for hepato-cerebral dystrophy,
      although in this disease they were observed in a greater number than in other
      diseases. Their dependence on the degree of portal hypertension and on some
      endocrine factors was noted. "Empty" nuclei were identified most often in the
      periportal regions and were characterized by a considerable increase in the
      volume, invaginations of the membrane, intranuclear inclusions, polyploidy. The
      study of polyploidy of the ordinary nuclei of hepatocytes in hepatocytes in
      hepato-cerebral dystrophy, bearing in mind the reduplicated DNA, revealed the
      predominance of diploid nuclei.

PMID- 1016097
TI  - [Functional morphology of vessels in the distribution of the pulmonary
      circulation of people adapted to the Northeast USSR].
AB  - Studies of the contrasted vessels of the lungs in practically healthy men who had
      lived in the north-eastern region of the USSR over 3 years and who had died of
      casual causes in Magadan were carried out by stereoroentgenogrammetry and
      morphometry. The studies revealed a rearrangement of the distribution arteries of
      the lesser circulation according to the hypervolemic type: a reliable dilatation
      of the lumen, thinning of the walls of the right pulmonary artery, superlobar
      trunk, branches of the segmentary arteries of the superior and middle lobes of
      the lung. The pronounced desorganization and perish of elastic laminae in the
      wall of the stretched arteries were compensated by the appearance of layers of
      the smooth muscles -- by the so-called hypermuscularization of arteries of the
      elastic type. The enlarged capapcity and intensification of the blood flow in the
      arteries of the superior and middle lobes of the lung represented an important
      mechanism of adaptation of the lesser circulation in man under extreme climatic
      conditions in the north-eastern region of the USSR.

PMID- 1016098
TI  - [Ultrastructural changes in the arterioles of rats with experimental salt
      hypertension].
AB  - The ultrastructure of arterioles in experimental salt loading in rats was
      studied. It was established that prolonged feeding with salt-rich diet led to
      stable hypertension in some experimental animals, and ultrastructural changes in
      arterioles were noted only in rats which had developed stable hypertension. The
      changes in arterioles in experimental salt hypertension in principle were similar
      to those observed in other chronic forms of hypertensive states, but they
      developed slower and were less pronounced. The present study does not confirm the
      views advocated by some authors about a direct effect of salt on the
      ultrastructure of the arteriolar wall. The mechanism responsible for the changes
      in the arterial wall occurring in experimental salt hypertension remains unclear.

PMID- 1016099
TI  - [Morphologic diagnosis of chordoma in children].

PMID- 1016100
TI  - [Hemodynamic study of patients with Starr-Edwards prosthesis in the mitral valve
      position].

PMID- 1016101
TI  - Fourteen year cardiological follow-up of patients with high and low levels of low
      density lipoproteins. I. The value of low density lipoprotein determination in
      serum as a reliable prognostic index of future myocardial infarction.

PMID- 1016102
TI  - [Centered Lillehei-Kaster disk prosthesis in valve substitutions. Initial
      results].

PMID- 1016103
TI  - [Considerations on the measuring technic of the left heart ventricle volume
      through cineventriculography. Study of the plastic models].

PMID- 1016104
TI  - [Sodium nitroprusside in the treatment of heart failure].

PMID- 1016105
TI  - [Vectorcardiographic studies of ventricular repolarization immediately after the
      ergometric test. Its relation with cineangiocoronariography].

PMID- 1016106
TI  - Double-outled right ventricle concept and classification.

PMID- 1016107
TI  - [Surgical management of the functional tricuspid valve insufficiency].

PMID- 1016108
TI  - [Myocardial infarct in patients with non-obstructive coronary insufficiency].

PMID- 1016109
TI  - [Malposition of the great arteries. Mitral valve saddling in the ventricular
      septum (mitral stradding) Report of a case. Part II. Embryological and
      pathological anatomy].

PMID- 1016110
TI  - Osteoporosis--some thoughts by a non-physician.

PMID- 1016111
TI  - Presentation and detection of chronic renal disease in children and adults.
AB  - Chronic renal failure develops slowly and insidiously in most patients.
      Prevention depends on the early detection and full assessment of the patient at
      risk. Indications for investigation in children and adults with
      glomerulonephritis and urinary infection are outlined.

PMID- 1016112
TI  - Investigation of urinary infection in childhood.
AB  - The first proven urinary infection in both girls and boys should be investigated
      with an IVP and micturating cystourethrogram. If both investigations are normal,
      recurrent infections will not produce renal scars. Renal scars will develop in 10
      per cent of children with reflux, unless renal infections are prevented by
      appropriate drug or surgical treatment.

PMID- 1016113
TI  - SI units in clinical pathology.
AB  - By now, most doctors in Australia will have had some experience with the new SI
      units which are being used for pathology test results, especially chemical
      pathology. While the usage of SI units has spread rapidly through public
      hospitals in Australia, spread in the non-hospital sector has been slower.
      However, the change will occur, and so the following is presented to assist
      general practitioners to understand the reasons for the change, and to interpret
      results expressed in the new system.

PMID- 1016114
TI  - Geriatric nursing care--a philosophy.

PMID- 1016115
TI  - Survey of general practice--1971.
AB  - In this survey an attempt has been made to document a profile of certain aspects
      of the work carried out by a general practitioner in Australia. This includes the
      type of practice, and especially the range and frequency of the procedures he
      carries out. It is realised that, as this survey was conducted in 1971, some of
      the facts may have become dated. However, a proportion of the information given
      is unobtainable elsewhere, and it is believed that through publishing the survey,
      interested readers may be prompted to seek additional information from the
      author.

PMID- 1016116
TI  - Problems in practice--head injury.

PMID- 1016117
TI  - Extending the role of the nurse into family practice.

PMID- 1016118
TI  - Country doctors in Western Australia.

PMID- 1016119
TI  - Effects of the sympathetic nervous system and the adrenal medullary hormones on
      dog hind limb blood flow after haemorrhage.
AB  - The contributions of the sympathetic nervous system and the adrenal medullary
      catecholamines to the response of dog hind limb resistance vessels to haemorrhage
      were examined. Anaesthetized dogs were bled either 30% or 45% of blood volume.
      There was little difference between the vascular conductance response in
      untreated hind limbs and sympathectomized limbs. Conductance in limbs that had
      been both sympathectomized and alpha-adrenergically blocked with phenoxybenzamine
      was markedly above that of untreated limbs. Blood flow in both the untreated
      limbs and the sympathectomized limbs was closely similar to that predicted from
      the pressure-flow curve for the hind limbs obtained in non-bled dogs. Flow was
      higher than predicted in the limbs with combined sympathectomy and alpha
      adrenergic blockade. It is concluded that the sympathetic nervous system exerted
      little vasoconstrictive influence after haemorrhage, but that circulatory
      catecholamines exerted a strong vasoconstrictive influence that was opposed in
      the normal limbs by an almost equally powerful vasodilatory force of undetermined
      origin.

PMID- 1016120
TI  - Release of gastrin by vagal stimulation in the acid secretory response to food.
AB  - Gastric pouches were constructed in 8 dogs; in 4 they were of denervated type and
      in 4 the innervation was intact. An oesophageal fistula was then prepared in each
      dog. The acid secretory response to oral, tube and sham feeding was determined
      before and after denervation of the pyloric antrum. The results support the view
      that vagal release of gastrin makes a relatively small contribution to the total
      acid secretory response to food.

PMID- 1016121
TI  - The origin of immunoglobulins in salivary secretion of sheep.
AB  - A comparative study was made on the secretion of IgG1 and IgA into parotid and
      submaxillary saliva of sheep. The purpose of the study was to examine the
      suggestion that in the external secretory organs of ruminants there is an inverse
      relationship between the capacity to selectively transfer IgG1 and the
      development of the IgA secretory system. Despite a marked difference in the
      secretion of IgA between the parotid and submaxillary salivary glands, the
      magnitude of selective transfer of IgG1 was similar. Thus, there appears to be no
      relationship between the selective transfer of IgG1 and the secretion of IgA into
      the saliva of sheep.

PMID- 1016122
TI  - Relationship between vasoconstriction and histamine induced vasodilation.
AB  - Histamine produced significantly greater vasodilation in rabbit ear arteries
      constricted by noradrenaline than when the same arteries were constricted by
      either caffeine or barium. Histamine dilation in the presence of caffeine was
      also significantly greater than that in the presence of barium. These results
      suggest that histamine may produce vasodilation through at least two different
      modifications of intracellular calcium mobilisation.

PMID- 1016123
TI  - An evaluation of selective broths based on the bi-selenite ion and on hypertonic
      strontium chloride in Salmonellae detection in egg products.
AB  - Of the 104 isolations of Salmonella sp. from egg pulp, 97 were obtained from
      strontium chloride M broth, 42 from strontium selenite broth and 57 from
      strontium selenite A broth. The results suggest that the first medium may be used
      more successfully than bi-selenite based media for enrichment and subsequent
      detection of salmonellae in egg products; however, the growth of S. pullorum was
      not satisfactory in strontium chloride M broth.

PMID- 1016124
TI  - Passive transfer of immunity to infection with Nematospiroides dubius from
      immunised mice to their offspring.
AB  - The results given below show that, whilst it is not possible to transfer immunity
      to infections with Nematospiroides dubius passively with serum from immune mice
      to normal adult mice, young born to immune females are resistant to this
      infection. The immunity is dependent on an intake of immunoglobulin via the milk
      for a period longer than 24 h. The passive transfer of immunity from immune
      mothers to neonatal mice does not appear to be dependent on a specific class of
      immunoglobulins.

PMID- 1016125
TI  - Intrahepatic microvascular changes in carbon tetrachloride-induced cirrhotic
      livers in the rat.
AB  - Liver cirrhosis was produced in the rat by combined carbon tetrachloride
      phenobarbitone treatment, and the microcirculation in the cirrhotic liver was
      observed by a quantitative in vivo transillumination technique. The total
      sinusoidal flow in the observed region of the cirrhotic liver did not differ
      significantly from that in the normal liver, despite the reduced number of
      sinusoids and the increased portal venous pressure. The cirrhotic liver also
      presented a fast-velocity population of portal and hepatic venules and sinusoids
      in addition to the normal slow-velocity population. The possible mechanism of
      these "arterialized" microvessels is discussed.

PMID- 1016126
TI  - Effect of the ligation of hepatic artery on the microcirculation in the cirrhotic
      liver in the rat.
AB  - The significance of the hepatic arterial supply in the intrahepatic
      microcirculation in normal and carbon tetrachloride-induced cirrhotic livers was
      studied by dye injection method and by ligation of the hepatic artery. The in
      vivo distribution of dye injected into the hepatic artery evidenced the presence
      of arterio-venous shunts in the cirrhotic liver. When the hepatic artery of the
      cirrhotic liver was ligated, the elevated portal venous pressure dropped
      significantly, and the fast-flowing population of microvessels and sinusoids in
      the bimodal frequency distribution plot disappeared. The fast-flowing microvessel
      and sinusoids appeared to be the "arterial" microvessels and sinusoids, and they
      were converted into the slow-flowing venous channels after hepatic arterial
      ligation. The transmission of arterial pressure via the A-V shunts may be of
      greater significance in the pathophysiology of portal hypertension than
      previously believed.

PMID- 1016127
TI  - Serological evidence of inter-epidemic infection of feral pigs in New South Wales
      with Murray Valley encephalitis virus.
AB  - The sera of 617 feral pigs, collected from three widely separated areas of
      northern and central New South Wales, were examined for antibody to Murray Valley
      encephalitis (MVE) virus and to Ross River virus. Haemagglutination-inhibition
      (HI) antibody was detected to MVE in 58% of sera and to Ross River virus in 15%
      of sera. Neutralization tests suggested that the MVE HI antibody resulted from
      infection with MVE virus in the summers of 1971-1972 and 1972-1973 when the virus
      was not known to be active in New South Wales. These same tests suggested that
      more than one flavivirus infected the feral pigs in the summer of 1973-1974 and
      that Kunjin virus was active in the summer of 1975-1976.

PMID- 1016128
TI  - Basophil leucocytes in cutaneous hypersensitivity reactions in nematode-infected
      guinea-pigs.
AB  - Cutaneous hypersensitivity reactions were elicited in guinea-pigs infected with
      the parasitic nematode Trichostrongylus colubriformis by injecting them with a
      crude extract of T. colubriformis fourth-stage larvae. The reaction was
      characterized by early oedema and pronounced cellular infiltration, initially
      with neutrophils but later with mononuclear cells, basophils and variable numbers
      of eosinophils. Because basophils have been implicated as effector cells in the
      protective immune response of guinea-pigs to this nematode, the capacity to
      elicit a basophil-rich cellular infiltrate in infected animals might be a useful
      assay for T. colubriformis protective antigen(s).

PMID- 1016129
TI  - The relationship between the transfer of immunoglobulins, sodium and potassium
      into mammary secretion of the parturient ewe.
AB  - The experiment comprised two sections. First, radiotracer techniques were used to
      study the metabolism of IgG1 and IgG2 in 5 non-pregnant and 4 pregnant ewes. In
      the pregnant ewes, the rates of synthesis for IgG1 and IgG2 were similar to the
      rates observed in non-pregnant animals. However, the irreversible loss of IgG1
      was significantly greater than IgG2 in pregnant ewes and IgG1 in non-pregnant
      ewes. Additionally, it was found that most of the IgG1 and virtually all of the
      IgG2 in mammary secretion was serum derived. Secondly, the levels of sodium,
      potassium and lactose and the selective index for IgG1 in mammary secretions of 5
      pregnant ewes were monitored over the parturient period. The values of all the
      measures remained relatively constant until one day before parturition. From one
      day pre-partum, the levels of potassium and lactose in mammary secretion began to
      increase and had risen 2-3 fold by 5 days post-partum. Over the same period, the
      selective index for IgG1 decreased 20 fold, wehreas the level of sodium fell from
      approximately 32 mmol/l to 18 mmol/l. The concentration of IgG1 in plasma slowly
      declined from approximately 23 g/l to 15 g/l over the last 10 days of pregnancy.
      During the parturient period, the decline in plasma IgG1 levels, in comparison
      with IgG2, without alteration in the rates of synthesis of either immunoglobulin,
      supports the hypothesis that selective transport of IgG1 into mammary secretion
      occurs without degradation. The results also indicate that the transport of
      sodium and potassium into mammary secretions are altered over the parturient
      period.

PMID- 1016130
TI  - Fibrinogen-like proteins and fibrinolytic proteins in a saline eluate from
      sucrose washed bovine erythrocytes.
AB  - Plasminogen and a spectrum of fibrinogen-like proteins are found in a saline
      eluate of sucrose washed bovine erythrocytes. It seems probable that these
      proteins are membrane bound in vivo, and, as such, their physiological
      significance is discussed.

PMID- 1016131
TI  - Inhibition of intestinal uptake of amino acids by unconjugated bile salt.
AB  - The unconjugated bile salt, sodium deoxycholate, at a concentration of 0.5 mM was
      shown to inhibit the intestinal uptake of the amino acids L-glycine, L-leucine, L
      proline, L-lysine and L-tyrosine in rats in vitro. This effect was acutely
      reversible except for the basis amino acid L-lysine and is therefore not simply
      due to tissue damage. These results, and the recent finding that sodium
      deoxycholate inhibits intestinal absorption of amino acids in vivo, suggest that
      impaired intestinal amino acid transport may contribute to hypoproteinaemia in
      patients with bacterial overgrowth in the upper small intestine in whom
      deoxycholate is present in the small intestinal lumen in excessive
      concentrations.

PMID- 1016132
TI  - The effects of 2-phenylalanine 8-lysine vasopressin (octapressin) on blood
      vessels in the rat tail.
AB  - Isolated perfused segments of the ventral rat tail artery have been used in this
      study to investigate the effects of octapressin on vascular smooth muscle and its
      interaction with other vasoconstrictor agents. It was found that repeated
      octapressin administration was associated with tachyphylaxis and that the onset
      and rate of development of this phenomenon could be modified by cocaine. The
      constrictor action of catecholamines, electrical stimulation and serotonin on the
      rat tail artery was potentiated by octapressin. Mechanisms which may be involved
      in octapressin tachyphylaxis are discussed.

PMID- 1016133
TI  - The induction of parturition using dexamethasone.
AB  - Premature parturition was successfully induced with a preparation containing 2
      dexamethasone esters in 709 out of 716 cows and heifers of gestational periods
      ranging from 3 to 8 months. A mortality rate of 38.5% was experienced among
      calves produced by induced cows, while only a 2.7% mortality rate occurred among
      4,330 calves from normal parturitions. Approximately 50% of all treated cattle
      retained foetal membranes, but with apparently no ill-effect. The treatment
      apparently did not affect milk production, post-calving fertility, and the
      overall incidence of dystocias in cows and post-calving diseases. Three deaths
      occurred among induced cattle, but they could not be attributed to the treatment.
      It was concluded that the technique may prove to be of great value in dairy
      cattle, in seasonal milking areas.

PMID- 1016134
TI  - Infection rates and outbreaks of disease due to Babesia argentina in unvaccinated
      cattle on 5 beef properties in south-eastern Queensland.
AB  - Serums from unvaccinated groups in 5 herds of beef-cattle in South-East
      Queensland were tested for antibodies to Babesia argentina at intervals while the
      cattle were increasing in age from about 6 months. An indirect fluorescent
      antibody test was used. Infection rates, indicating the proportions of the groups
      that had been exposed to tick-transmitted infection were 49.2, 56.9 and 69.1% for
      cattle aged approximately 6, 12 and 18 months, respectively. The degree to which
      cattle were infested with the vector, Boophilus microplus, was estimated. There
      appeared to be a strong correlation between infection rate and tick incidence.
      Four serologically negative animals died of either confirmed or suspected
      babesiosis during the sampling period. Sickness was observed in 5 others. The
      serological status of 57 changes from negative to positive without symptoms being
      observed, indicating relatively low mortality and morbidity rates in the enzootic
      situation studied.

PMID- 1016135
TI  - Vaccination with Babesia argentina in 5 beef herds in south-eastern Queensland.
AB  - Observations on the use of a vaccine containing Babesia argentina in 5 partly
      susceptible beef herds in south-eastern Queensland were made on 1,029 female
      breeding cattle over a period of 4 years. Groups averaging about 20 heifers were
      given 0, 1, 2 or 3 vaccinations. Incidence derived from groups experiencing
      clinical attacks were 17.9% for unvaccinated cattle and 1.2% for vaccinates.
      Increasing the number of vaccinations did not appear to increase protection. The
      one clinical manifestation of infection with B. bigemina was associated with a
      concurrent reaction to vaccination with Anaplasma centrale. There were no cases
      of haemolytic anaemia in new-born calves. No severe reactions followed primary
      vaccination, but 2 revaccinated animals became sick.

PMID- 1016136
TI  - Tuberculosis-like granulomas in cattle caused by Actinomycetes.
AB  - From 280 lesions from normal cattle at slaughter, 10 were found to contain thin,
      branching, Gram-positive organisms belonging to the Nocardia/Streptomyces group
      and this was confirmed by culture in 3 cases. Macroscopically the older lesions
      were similar in appearance to those of tuberculosis. Microscopically, all lesions
      contained numerous foreign body giant cells and thin, branching organisms. The
      older lesions also contained areas of necrosis, caseation, mineralisation and
      fibrosis.

PMID- 1016137
TI  - A pathological and bacteriological study of the mammary glands of beef cows in
      north Queensland.
AB  - Pathological and bacteriological studies were made of a total of 507 udders from
      slaughtered beef cows originating from various locations in northern Queensland.
      Incidence of supernumerary tests was 28%, their distribution being caudal (80%),
      intercalary (8%), ramal (5%) and anterior 1%; 6% had both caudal and intercalary
      teats. They were seen most frequency in British breed and British-Brahman
      crossbreds (each 29%) and less frequently in Brahmans (22%). Gross lesions were
      found in 11.4% of cows; these lesions comprised cysts (2.8%), leech infestation
      (1.0%), mastitis (0.6%), teat occlusionsion (3.9%), papillomatosis (1.2%),
      cutaneous horns (0.4%), teat fistulas (0.4%), teat trauma (0.6%) and udder
      fibrosis (0.6%). Mastitis was obviously low in occurrence, while leech
      infestation and teat occlusion were relatively frequent in cows from one area.
      Bacteriological examination of single quarters in 364 cows, revealed infection in
      154 (42.3%). A total of 199 isolations were made of which 3.5% were recognised
      mastitis pathogens. Pathological conditions were found, and bacterial isolations
      were made more frequently in aged than in mature or young cows.

PMID- 1016138
TI  - Polyarthritis of pigs in western Australia: the role of Erysipelothrix
      rhusiopathiae.
AB  - A 3-month survey of polyarthritis in pigs was carried out at 3 metropolitan
      abattoirs in Western Australia. The incidence of total carcass condemnations for
      polyarthritis was 0.46% and partial condemnation for "arthritis" 1.66% of 15,919
      pigs. It was demonstrated that the majority of joint lesions found in either
      total or partial condemnations were identical pathological conditions, usually
      differing only in the number of joints involved. Erysipelothrix rhusiopathiae was
      isolated from the joints of 63% of pigs condemned for polyarthritis; it appears
      that this organism is the most significant aetiological agent of polyarthritis in
      Western Australia. The role of mycoplasmas has not been determined. The groww and
      microscopic lesions seen in affected joints were those of a non-suppurative
      proliferative polysynovitis. The stifle and elbow joints showed the highest
      incidence of the most severe lesions. Pigs condemned for polyarthritis over a 6
      month period were traced back to 125 farms. Eighty per cent of pigs that had been
      condemned for polyarthritis had not been vaccinated against erysipelas or were of
      doubtful vaccination status. Only 3% of pigs had been vaccinated as recommended.
      The results would suggest that erysipelas vaccine is not directly implicated in
      the pathogenesis of polyarthritis. The majority of pigs condemned for
      polyarthritis originated from poorly managed small piggeries run as sideline
      enterprises. There was no significant pattern to the geographical distribution of
      polyarthritis cases in Western Australia. Likewise, no significant realtionship
      was established between polyarthritis condemnations and either breed, sex or
      bodyweight of thepigs involved.

PMID- 1016139
TI  - Complications following a ruptured bladder in a 60-day-old foal.
AB  - The death of a 60-day-old foal due to massive haemorrhage associated with erosion
      of the left umbilical artery into the left ureter is reported. Surgical repair
      attempts are described together with post-mortem findings.

PMID- 1016140
TI  - The "Dag" and swollen abaxial midpiece spermatozoan defects in bulls.

PMID- 1016142
TI  - The veterinary profession and the future in Australia.

PMID- 1016141
TI  - Some thoughts on academic institutions.

PMID- 1016143
TI  - Supply and demand for veterinarians in Australia.

PMID- 1016144
TI  - Osteoarthrosis of the elbow joint in dogs.

PMID- 1016145
TI  - Babesiosis of a horse in Australia.

PMID- 1016146
TI  - The species of flies reared from struck sheep in south-eastern Australia.

PMID- 1016147
TI  - Mimosine in Leucaena leucocephala is metabolised to a goitrogen in ruminants.

PMID- 1016148
TI  - Avulsion of the tibial tuberosity in the greyhound.

PMID- 1016149
TI  - Congenital bovine epizootic arthrogryposis and hydranencephaly in Australia.
      Distribution of antibodies to Akabane virus in Australian Cattle after the 1974
      epizootic.
AB  - At the end of the 1974 epizootic of bovine congenital arthrogryposis and
      hydranencephaly in south-eastern New South Wales, an Australia-wide serological
      survey (about 4,000 serums) was made to determine the ditribution of cattle
      possessing serum neutralising antibodies against Akabane virus. Eighty per cent
      of the serums from cattle in northern Australia (Western Australia, Northern
      Territory, and Queensland) were positive. A detailed study in the epizootic area
      in New South Wales (particularly around Bega) showed that 80 to 100% of serums
      from cows in herds in this area possessed neutralising antibodies. The animals
      possessing antibodies extended as far south as Genoa in north-eastern Victoria,
      and as far west as Darlington Point on the Murrumbidgee River. There were no
      positive herds along the Murray River, where an outbreak of the mosquito-borne
      disease Murray Valley encephalitis occurred in 1974. Serums tested from cows in
      the rest of Victoria, South Australia, south-western Western Australia, and
      Tasmania were negative. Arthrogrypotic calves born in Tasmania and south-western
      Western Australia were not associated with the presence of Akabane virus. In
      Papua New Guinea, serums collected from cattle at Boroka, Lae, and Goroka did not
      possess neutralising antibodies. The distribution of cattle possessing antibodies
      in Australia would fit a spread of the virus by Culicoides brevitarsis, a biting
      midge from which Akabane virus had been isolated on three occasions. The
      possibility of other vectors, as well as C. brevitarsis, was suggested by the
      presence of cows possessing antibodies at Alice Springs, where this biting midge
      has not been found. Possibly most cattle in northern Australia become infected
      early in life. The epizootics in New South Wales could occur when seasonal
      conditions allow a southerly extension of virus-infected C. brevitarsis which
      feed on susceptible pregnant animals. C. brevitarsis also bites sheep, and both
      neutralising antibodies to Akabane virus and congenitally deformed lambs have
      been observed in the epizootic area. An understanding of the distribtuion of
      Akabane virus and C. brevitarsis, a possible Australian vector for bluetongue
      virus, may prove useful if bluetongue should enter Australia.

PMID- 1016150
TI  - A review of respiratory agents associated with disease of sheep, cattle and pigs
      in Australia and overseas.

PMID- 1016151
TI  - Custom collection and processing of bull semen.
AB  - Three systems of custom collection and processing of semen are reported. In the
      first system, semen was collected, evaluated and partially diluted and returned
      to a central Government laboratory for final dilution and freezing. In the second
      system the procedure was similar to the first except the semen was returned to
      the author's laboratory for final dilution and freezing. System 2 reduced the
      failure to process rate from 20.4% to 6%, but did not significantly improve
      fertility (64% v's 68% for systems 1 and 2 respectively). A single-stage diluent
      was used in system 3 and the time from collection to freezing in the author's
      laboratory was reduced. Both the failure to process rate (0.1%) and the fertility
      rate of the semen (76%) improved over the other 2 systems.

PMID- 1016152
TI  - Control of reproductive function of cattle using cloprostenol.
AB  - Two intramuscular injections of cloprostenol were given 12 days apart to
      synchronise oestrus in a group of 47 heifers and following the second injection,
      38 were found in oestrus in 2 to 6 days, 1 in 11 days and 8 in 22 to 27 days. The
      conception rate of the synchronised animals was 24 of 38 (63%). Twenty-nine
      heifers were given injections of cloprostenol in late pregnancy and parturition
      was induced with a latent period of 6 +/- 3 days when injected at 266 to 267
      days. When injected at 254 to 262 days, 3 of 16 heifers (19%) were unresponsive
      and the remainder calved with a latent period of 12 +/- 6 days. The survival rate
      of calves from induced heifers was 71% with 80% survival from controls.
      Approximately 50% of the induced heifers, and none of the controls, retained
      their foetal membranes.

PMID- 1016153
TI  - The incidence of dystocia in Dorset Horn ewes.
AB  - The incidence of dystocia was recorded in flocks of Dorset Horn ewes lambing in
      winter, spring or summer and grazed at 8, 12 or 16 ewes per hectare over a ten
      year period. The mean incidence of dystocia was 34% of ewes lambing.
      Significantly more ewes experience a difficult birth at winter (35%) and spring
      (39%) than summer (26%) lambings. Neither stocking rates nor pre-lambing ewe
      bodyweight were related to the incidence of dystocia. The incidence of dystocia
      was significantly greater in 2-year-old ewes than in any other age group. Foetal
      size was of major importance in the occurrence of dystocia. Approximately 60% of
      single and twin born lambs that had birth weights greater than 4.5 kg had a
      difficult birth whereas in lambs weighing less than 3.2 kg only about 10% were
      affected. Thirty-six per cent of all perinatal mortality was attributable to
      dystocia. Approximately 27% of single and 73% of twin presentations in assisted
      births were abnormal, 31% of all lambs assisted had 1 or both legs retained, 4%
      had posterior (including breech) presentations and the remaining 8% were of
      varied forms of malpresentation. Significantly more single male than female lambs
      experienced a difficult birth and the mean birth weights of single, twin and
      triplet born lambs that had a difficult birth were greater than the birth weights
      of singles, twins and triplets born normally.

PMID- 1016154
TI  - Simulated natural infection of chickens with Australian lentogenic newcastle
      disease virus and subsequent challenge with virulent virus.
AB  - A total of 291 eight-week-old chickens were exposed to chickens infected with
      either of two Australian lentogenic strains (V4 and AVL NDV-1) of Newcastle
      disease virus (NDV). At 3 weeks after exposure, all chickens exposed to V4
      infected chickens had developed haemagglutination-inhibition (HI) antibody. All
      chickens exposed to AVL NDV-1 virus infected chickens had developed HI antibody 5
      weeks later. This sudden late appearance of HI antibody, to titres higher than
      those observed with V4 chickens, was explained by V4 virus being introduced to
      the AVL NDV-1 group of chickens. When groups of these chickens were challenged
      with Roakin virus (mesogenic NDV) at 3 weeks and Fontana 1083 virus
      (viscerotropic velogenic NDV) and Texas GB virus (neutrotropic NDV) at 3, 5, 10
      and 21 weeks only three chickens developed clinical illness one of which died.
      These chickens were one AVL NDV-1 chicken contact challenged with Fontana 1083
      virus at 3 weeks, one V4 chicken oronasally challenged with Texas GB virus at 5
      weeks and one V4 chicken challenged oronasally with Fontana 1083 virus at 10
      weeks. Susceptible non-vaccinated chickens died soon after challenge. Challenge
      by oronasal infection with 10(7.0) ELD50 of virus or contact with susceptible
      infected chickens enabled virulent virus to be isolated from most chickens and
      was accompanied by a large anamnestic increase in serum HI antibody.

PMID- 1016155
TI  - Some factors affecting the measurement of blood inorganic phosphorus in cattle.
AB  - Sixty cows were studied over 3 days, to determine the effect of site of sampling,
      handling stress and the tranquilliser xylazine hydrochloride, on blood inorganic
      phosphorus (P). Jugular venous and coccygeal mixed arterial and venous blood were
      compared. Saliva was also analysed for P. Buffered and unbuffered trichloracetic
      acid (TCA) were compared as deproteinising agents. Tail blood P was consistently
      12% (range 7-17%) higher than that from the jugular vein (P less than 0.01). This
      difference decreased when jugular blood was sampled first but increased following
      administration of the tranquilliser. The drug significantly (P less than 0.01)
      increased the concentration of P in the saliva on 2 out of 3 days. The possible
      role of salivary P in affecting jugular P values, is discussed. The buffered TCA
      analyses gave consistently lower P readings than the unbuffered analyses. The
      magnitude of this effect was time dependent, being greater when the samples were
      left for 4 days (P less than 0.05) than when analysed the next day. There was a
      very strong correlation between plasma and whole blood P. It was concluded that
      the tissue of choice in phosphorus studies is tail blood (plasma or serum)
      treated with buffered TCA.

PMID- 1016156
TI  - Scrotal mesothelioma in a bull.

PMID- 1016157
TI  - An attenuated vaccine against bovine ephemeral fever.

PMID- 1016158
TI  - Suspected aspergillosis in a dog.

PMID- 1016159
TI  - Treatment of pregnancy toxaemia in ewes by induction of parturition.

PMID- 1016160
TI  - Lesions in sheep and guinea pigs pen fed parasitised annual ryegrass (Lolium
      rigidum)

PMID- 1016161
TI  - Artificial insemination of horses.

PMID- 1016162
TI  - Stimulation of the development of infective Babesia bovis (= B. argentina) in
      unfed Boophilus microplus larvae.

PMID- 1016163
TI  - Equine hydatidosis in Australia.

PMID- 1016164
TI  - A study of nephritis of beef cattle in North Queensland.
AB  - The incidence of subclinical nephritis in beef cattle slaughtered at a Townsville
      abattoir during the period 1970-73 was 3.8 percent. A rising incidence coincided
      with the wet summer of 1973-74 reaching a peak of 8.2 percent thereafter in June
      1974. All but 1 of 100 cases macroscopically identified as nephritis and studied
      histologically proved to be of interstitial type in which lymphocytic
      infiltration predominated. Follicular lymphoid hyperplasia was also a common
      feature. The exceptional case showed proliferative glomerulonephritis.
      Leptospires were isolated from 16 percent of cases cultured, and observed in 8
      percent of specimens examined histologically. All of the 8 isolates subjected to
      serogrouping were L. pomona. Of the animals tested serologically against 2
      serotypes 66.2 percent were positive to L. pomona (33.8 percent), L. hardjo (18.9
      percent) or both (13.5 percent). The total incidence is significantly higher than
      in other random surveys carried out in the region. These findings suggest that
      Leptospira sp. are a major cause of bovine nephritis. Since other pathogens
      endemic in the area, for example, Babesia and Theileria sp., may be capable of
      causing nephritis in cattle an accurate assessment of the aetiology of that form
      of renal disease in north Queensland cannot yet be made.

PMID- 1016165
TI  - Anthelmintic treatment of young beef cattle in the Wallum region of south-eastern
      Queensland.
AB  - An anthelmintic treatment trial on 125 Brahman-British crossbred 2 to 4 month old
      calves was undertaken on Wallum country in south eastern Queesland. The calves
      were divided into 5 experimental groups, grazed together and treated as follows
      for 17 months: Group 1--Untreated controls; Group 2--Monthly levamisole-
      niclosamide on 4 occasions; Group 3--Monthly levamisole until 1 month after
      weaning; Group 4--Levamisole 3 to 6 weeks after saturating rains; Group 5--No
      levamisole--niclosamide as for Group 2. The mean body weight gains for cattle in
      Groups 1 to 5 were 95, 124, 105, 121 and 97 kg respectively. Four cattle were
      lost from each of Groups 1 and 3 and five from Group 5. Most of these losses
      occurred towards the end of the second summer rainfall season. Faecal egg count
      maxima were recorded around weaning in untreated groups and during the summer
      rainfall period of both the first and second summer in all groups. The most
      prevalent nematode species encountered were H. placei, Cooperia spp and O.
      ostertagi. It is recommended that in this region cattle under 2 years of age
      should receive anthelmintic treatment at least in autumn and spring.

PMID- 1016166
TI  - Humpy back of sheep. Clinical and pathological observations.
AB  - Humpy back, a disease of Merino sheep in western Queesland, occurs during
      mustering for shearing. It is usually seen in summer 6-10 weeks after substantial
      rainfall and is thought to be caused by the ingestion of a toxic plant. The
      disease is characterised clinically by a short-stepping, stilted gait of the hind
      limbs, followed by lowering of the head, arching of the back and inability to
      continue walking. Histopathological examination of 8 cases from 5 properties
      revealed a Wallerian degeneration of the white matter throughout the length of
      the spinal cord with the ventral and lateral columns most severely affected. A
      similar degenerative change was seen in the posterior cerebellar peduncles of 3
      of the sheep. A more severe hind limb incoordination with more extensive
      degeneration of the white matter of the spinal cord, medulla and cerebellum was
      seen in a case of humpy back of two years duration. Similar, but much milder,
      spinal cord lesions were found in apparently unaffected sheep from the same group
      as the sheep affected with humpy back on 2 properties. Severe myodegeneration of
      hind limb muscle groups was seen in 3 affected sheep. It was thought to be
      associated with the long rail journey (1500 km) to the laboratory after the sheep
      were affected in the field.

PMID- 1016167
TI  - Studies on the prevalence of ringworm among horses in racing and breeding
      stables.
AB  - A survey of 568 horses in training and 2,535 horses on breeding farms has shown
      32 percent of the horses in training to be clinically affected while only 1.1
      percent of breeding horses were affected with pathogenic dermatophytes. The
      majority of lesions on racing horses were located on the girth areas.
      Trichophyton equinum var. autotrophicum, M. canis and M. equinum were found to be
      restricted to racing horses only. M. gypseum occurred in racing, riding and
      breeding horses.

PMID- 1016168
TI  - A standardised haemagglutination inhibition test for porcine parvovirus antibody.
AB  - Basic variables of the haemagglutination inhibition (HI) test for porcine
      parvovirus antibody were investigated. Nonspecific serum inhibitors were
      satisfactorily removed without loss of specific antibody when undiluted serum was
      adsorbed with 25 percent kaolin in borate saline at pH 9.0. Natural
      haemagglutinins in test serums could be completely removed using 0.1 ml of packed
      erythrocytes to 0.6 ml of kaolin treated serums. Adsorption of prediluted serum
      resulted in a depression of specific antibody titres. Highest HI titres were
      obtained using guinea pig erythrocytes, following incubation of virus-serum
      mixtures for 18 hours at 4 degrees C, 3 hours at 25 degrees C or 2 hours at 37
      degrees C. Micro- and macro-tests gave comparable HI titres.

PMID- 1016169
TI  - Leptospiral agglutinins in dogs in Sydney.
AB  - From June 1971 to June 1972, sera from 600 dogs in Sydney were tested for
      leptospiral agglutinins by a rapid slide agglutination method. The end-point
      titre was taken at 50 percent agglutination of the live organisms. Forty-one
      samples (6.8 percent) had a significant leptospiral titres (100 or greater) and 5
      of these reacted to 2 serotypes. Thirty serums (5 percent) contained agglutinins
      against L. copenhageni, and 6 (1 percent) against L. pomona, while a few samples
      reacted against hardjo, tarassovi, australis, grippotyphosa or pyrogenes
      serotypes. No significant titres were found to L. canicola, L. hebdomadis, L.
      autumnalis or L. bataviae.

PMID- 1016170
TI  - Suspected equine infectious anaemia in a foal.

PMID- 1016171
TI  - Solanum esuriale, a possible cause of humpy back in sheep.

PMID- 1016172
TI  - Extension of the range of Rhipicephalus sanguineus in Western Australia.

PMID- 1016173
TI  - The role of dietary fat in alleviating fatty liver and kidney syndrome in
      broilers.

PMID- 1016174
TI  - Reactivation of recent or remote memory before electroconvulsive therapy does not
      produce retrograde amnesia.

PMID- 1016175
TI  - Dissociation of odor and taste in shock-avoidance learning.

PMID- 1016176
TI  - Parallel but independent effects of pentobarbital and scopolamine on hippocampus
      related behavior.

PMID- 1016177
TI  - A comparison of free-operant shuttle avoidance in Mongolian gerbils and albino
      rats.

PMID- 1016178
TI  - Differentiation of response biases elicited by scopolamine and d-amphetamine:
      effects on habituation.

PMID- 1016179
TI  - An experimental test of diaschisis.

PMID- 1016180
TI  - Social and genotypic aspects of open-field behavior of two lines of mice.

PMID- 1016181
TI  - The response of male guppies (Poecilia reticutata, Peters) to repeated exposure
      to an open field.

PMID- 1016182
TI  - Adaptation and aversive brain stimulation. II. Effects of current level and pulse
      frequency.

PMID- 1016183
TI  - Adaptation and aversive brain stimulation. III. Excitability characteristics of
      behaviorally relevant neural substrates.

PMID- 1016184
TI  - Conditioned taste aversion: oral and postingestional factors.

PMID- 1016185
TI  - The CNS weighting of external and internal factors in feeding behavior.

PMID- 1016186
TI  - The influence of calcium and beta-sympathomimetics on force-frequency
      relationship and resting potentiation in guinea pig papillary muscle.
AB  - The influence of various calcium concentrations and of the beta-sympathomimeticum
      orciprenaline (Alupent) on the force-frequency relationship and on the resting
      potentiation of isolated isometrically contracting papillary muscles of the
      guinea pig heart was studied. Elevation of Ca concentration and/or addition of
      orciprenaline augment the amplitudes of contractions elicited by rhythmical
      stimulation, but they diminish the amplitudes of test contractions elicited after
      a test interval of 1-2 s. It is suggested that calcium and orciprenaline
      strengthen the calcium loss from the sarcoplasmic reticulum out of the cell
      during a prolonged interval.

PMID- 1016187
TI  - Evaluation of physical performance by rectangular-triangular bicycle ergometry
      and computer-assisted ergospirometry.
AB  - A great deal of information about physical adjustment to work can be obtained
      from quantitative stress testing. Maximal stress limited by symptoms of
      exertional intolerance is the concept of the 2 min duration work increment test
      (rectangular-triangular exercise test). Compared to steady-state work tests
      strict observation of the standardized procedure- and computer assisted
      evaluation of ergospirometric parameters offer innovatory opportunities: (1) the
      test is of short duration (8-14 min), (2) the subjects recover rapidly, even from
      an exhausting test, (3) one is more likely to be able to observe plateauing of
      VO2, should determination of maximal VO2 be desired, (4) adaptation to increasing
      work rates and maximal work capacity is assessable, (5) computer technics provide
      on-line assessment of aerobic and anaerobic power in quantitative terms, (6)
      measurements proved to be highly reproducible, (7) the relationship between
      variables such as increments of heart rate and systolic blood pressure,
      respiratory minute volume, oxygen uptake during the early phase of the non-steady
      state condition and the index of anaerobic power, and the influence of factors
      such as work load and work output, has been studied to derive standard values.
      Soft-ware programs have been designed to estimate deviation of parameters
      actually measured from standard values in terms of multiples of the standard
      deviation of the standard regression line. In particular, evaluating oxygen
      uptake during short time-intervals (0.5 min) provides information about adequate
      adaptational forces of the cardio-circulatory system. Energy that is not
      accounted for by reactions involving the VO2 measured is computed by substracting
      the caloric equivalent of oxygen uptake during work exceeding the steady-state
      level during rest from the energy demand to sustain a given work load
      aerobically. This index of anaerobic power is defined in kcal, cal/kg body wt.,
      and as a percentage of the total amount of energy required (moderately trained
      athletes 350-500 cal/kg; sedentary people 200-300 cal/kg). A close relationship
      to parameters of metabolic acidosis (base excess) exists. It is concluded that
      the physical performance of sedentary people, athletes and patients with impaired
      cardio-pulmonary function can be more precisely qualified in quantitative terms
      by means of computer assisted rectangular-triangular ergospirometry. Results
      obtained in patients with diseased conditions must be carefully interpreted,
      their condition suggesting the use of more invasive investigations to reveal the
      pathophysiologic mechanism.

PMID- 1016188
TI  - [A variant analysis of static body mass, height, surface area, radiological heart
      volume and aerobic capacity. Comparison findings between 200 high performance
      athletes with 80 untrained persons (author's transl)].
AB  - Static body mass and parameters of aerobic capacities were investigated in 200
      high performance athletes and 80 untrained persons. The results were subjected to
      a variant analysis. A subdivision of the athletes into strength and endurance
      sports has been shown to be of value. The mean range in untrained persons,
      strength athletes, endurance sports athletes and other athletes is presented.
      Significant variations were observed. Body mass, height and surface area was
      measured and the findings in athletes and untrained persons were compared. From
      the variant analysis of absolute and relative heart volume, the statement can be
      made, that athletes have larger hearts and that differences between sports exist.
      On the average the maximal O2-Puls and maximal Wattpuls as a measure of the
      aerobic capacity are greater in trained than in untrained persons. A close
      correlation between maximal O2-Puls and Wattpuls was demonstrated. Between
      strength and endurance athletes significant differences in both parameters are
      observed. A comparison of several statistics from the West German sport medicine
      literature of recent decades has shown, that in spite of changes in training
      quality and quantity in high performances athletes no evidence could be found for
      an increase in the performance parameters of the aerobic capacity.

PMID- 1016189
TI  - Maximal rate of pressure rise and time parameters in the right ventricle under
      isovolumic conditions. Investigations in the canine heart-lung preparation.
AB  - In contrast to the left ventricle, the maximal rate of intraventricular pressure
      rise in the right ventricle does not occur within the isovolumic phase of the
      contraction. Occlusion of the pulmonary artery by inflation of a balloon during
      the diastole causes an isovolumic systole of the following heart beat. The canine
      heart-lung preparation was used to test whether dP/dtmax measured isovolumically
      and the peak ventricular pressure Pmax as well as the parameters derived are
      useful indices for the contractile state of the right ventricle. Changes only of
      the aortic pressure influence neither dP/dtmax, Pmax and the time values from the
      onset of contraction to dP/dtmax (t-dP/dtmax), nor the time to Pmax (t-Pmax). A
      rise in heart frequency leads to an increase in dP/dtmax and Pmax at lowered
      enddiastolic pressure. It does not influence the time interval t-dP/dtmax and t
      Pmax. With augmented diastolic filling, dP/dtmax as well as Pmax increase, and t
      dP/dtmax and t-Pmax are extended. The present study suggests that dP/dtmax and
      Pmax measured isovolumically provide accurate and practical measurements of right
      ventricular contractility, provided that changes in enddiastolic pressure and
      heart frequency are taken into account. The time parameters are found to be not
      useful.

PMID- 1016190
TI  - The maximal rate of pressure rise in the right ventricle of isolated canine
      hearts in isovolumic and auxotonic systole under various hemodynamic and
      inotropic conditions.
AB  - The influence of changes in pre- and afterload, heart frequency and inotropic
      state on the difference between right ventricular dP/dtmax measured
      isovolumically and auxotonically has been investigated in canine heart-lung
      preparations. Isovolumic systoles were obtained by occluding the pulmonary artery
      during diastole by balloon inflation. The mean difference between isovolumic and
      auxotonic dP/dtmax is 40 mm Hg/sec (15 to 80 mm Hg/sec) - i.e. about 10% of the
      value measured auxotonically. Neither hemodynamic (pre- and afterload changes)
      nor inotropic changes influence this difference. Heart rate increase from 140 to
      200/min also has no effect. This corresponds with the unchanged time interval
      between pulmonary valve opening and right ventricular dP/dtmax under all these
      conditions. Only heart rates below 100/min seem to enhance the difference between
      isovolumic and auxotonic dP/dtmax. Since the difference is not altered at various
      inotropic states, the result of this study leads to the conclusion that the
      relative changes in contractility could be slightly overestimated by using the
      auxotonic dP/dtmax for inotropic assessment. Practically, this inexactitude is
      within the error range of the method. Therefore, the use of dP/dtmax measured
      auxotonically does not introduce a marked disadvantage related to isovolumic
      dP/dtmax for assessment of relative inotropic changes of the right ventricle in
      isolated hearts.

PMID- 1016191
TI  - [The noninvasive determination of cardiac output by means of impedance
      cardiography. Comparative evaluation with a thermal dilution technique (author's
      transl)].
AB  - When a high frequency alternating current is passed through the thorax by means
      of tape-electrodes, the electrical impedance Z is changing synchronously with the
      cardiac cycle. The relation between the first derivative dZ/dt and the stroke
      volume is the basis for the application of impedance cardiography (IK)
      Determinations of cardiac output (CO) at rest during ergometer exercise using
      this noninvasive technique were compared with CO values obtained by the thermal
      dilution method. In 57 subjects simultaneous determinations using both methods
      were performed at resting conditions. The correlation coefficient was r = 0.63.
      In addition, in 48 of the subjects CO was measured with both methods during
      supine ergometer exercise. Comparison of the exercise values resulted in a
      correlation coefficient of r = 0.63. In all 48 cases there was a concordant
      change of the IK and thermodilution CO values. It is concluded that relative
      changes of CO are reliably detected by IK. The absolute values can be utilized
      only approximately.

PMID- 1016192
TI  - Hemodynamic response to digitalization in patients with hypertensive
      cardiovascular disease.
AB  - Twenty-eight patients with hypertensive cardiovascular disease (HCD) and
      incipient myocardial dysfunction underwent hemodynamic studies at rest and during
      exercise before and 30 minutes after administration of 0.6 mg beta-methyl-digoxin
      intravenously. Measurements were made during right heart catheterization with a
      balloon-tipped catheter. The hemodynamic changes after administration of
      digitalis did not demonstrate a consistent and uniform improvement of cardiac
      performance in all patients with HCD and myocardial dysfunction. When separating
      11 patients with pervious myocardial infarctions or documented coronary artery
      disease (CAD) (= Group I) from the remaining 17 subjects without clinical and/or
      angiographic signs of CAD (= Group II), there were significant differences in the
      hemodynamic response to digitalis: In Group I, pulmonary artery wedge pressure
      (PAWP) after digitalis decreased only slightly and insignificantly from 8.7 to
      7.4 mm Hg at rest and from 27.6 to 26.4 mm Hg during steady state exercise.
      Cardiac output (CO) remained essentially unchanged with a tendency to decrease
      after digitalis: 5.9 vs. 5.8 L/min at rest and 11.5 vs 11.1 L/min during
      exercise. At rest, even patients of Group II showed only minor decrease of PAWP
      from 8.8 to 7.2 mm Hg; during exercise these patients demonstrated marked
      improvement of cardiac performance with a significant decrease of PAWP after
      digitalis from 27.8 to 22.3 mm Hg (p less than 0.01). With one exception, there
      was a more or less pronounced reduction of PAWP after the drug was given. No
      significant change of CO after digitalis was measured in this group: 6.2 vs. 5.9
      L/min at rest and 13.4 vs. 13.5 L/min during exercise. The different hemodynamic
      patterns of responders and non-responders to the glycoside will be discussed.

PMID- 1016193
TI  - Experimental hypothyroidism: depression of myocardial contractile function and
      hemodynamics and their reversibility by substitution with thyroid hormones.
AB  - Hemodynamics and myocardial muscle mechanics have been studied in 22 euthyroid
      and 60 hypothyroid cats in which experimental hypothyroidism has been produced by
      thyroidectomy 61 days prior to the examination. Left ventricular to body weight
      ratio was altered due to a decrease in left ventricular weight and an increase in
      body weight. Heart rate, cardiac output and cardiac index were decreased (by 12
      15 per cent), whereas stroke volume remained unchanges. Peak systolic pressure of
      the left ventricle was moderately decreased, the other pressures were in the
      normal range. There was a marked and significant reduction of isovolumic
      contractility indices indicating a depression of myocardial contractility in situ
      by 20-27 per cent. The isolated ventricular myocardium exhibited decreases of
      isotonic muscle shortening, of maximum isometric tension development and of the
      rates of both, isotonic shortening and isometric tension development by 12-35 per
      cent. Force-velocity relationships of contraction and relaxation were depressed
      to lower values of contraction and relaxation velocity as well as of maximum
      isometric muscle tension. The alterations in myocardial muscle mechanics and
      hemodynamics were completely reversible following substitution of the hypothyroid
      group with physiological doses of L-thyroxine (5 mug/kg/day for 8-18 days).
      Excess increases of parameters of myocardial performance were found following
      substitution of the hypothyroid group with L-thyroxine (500 mug/kg/day) in
      accordance with the induction of experimental hyperthyroidism in these animals.
      The results demonstrate impaired myocardial contractility and hemodynamics in
      experimental hypothyroidism. These changes are completely reversible by
      substitution with L-thyroxine in accordance with a reversible thyroid
      cardiomyopathy. The cellular mechanisms responsible for the altered cardiac
      activity in experimental hypothyroidism are discussed.

PMID- 1016194
TI  - The influence of dihydroergotamine on adenosine-induced and reactive coronary
      vasodilation. Interaction of dihydroergotamine and coronary vasodilation.
AB  - The influence of dihydroergotamine on adenosine-induced and reactive vasodilation
      after long and short periods of coronary artery occlusion was investigated in
      thoracotomized dogs. Adenosine-induced vasodilation (intracoronary
      administration) and vasodilation after long periods of coronary artery occlusion
      (25-35 beats) were similarly influenced, i.e. decreased by the i.v.
      administration of 10 mug/kg dihydroergotamine. By contrast vasodilation after
      short periods of coronary artery occlusion (4-7 beats) tended to be increased.
      This difference in response is thought to arise from two distinct mechanisms of
      coronary vasodilation after coronary artery occlusion depending on the duration
      of the occlusion period. The vasodilation after short periods of coronary artery
      occlusion possibly corresponds to physiological autoregulation. With longer
      periods of coronary artery occlusion an additional, consecutive mechanism is
      called into action.

PMID- 1016195
TI  - Effects of fendilin hydrochloride (sensit) on systemic and coronary hemodynamics
      and on retrograde coronary blood flow in dogs.
AB  - Fendilin hydrochloride was tested in 9 normal anesthetized dogs and in 7
      anesthetized dogs with acute coronary artery occlusion. The compound (1 mg/kg
      i.v.) caused a slight short lasting increase in coronary blood flow together with
      an increase in cardiac metabolic rate for oxygen of similar magnitude. There was
      no measurable effect on collateral conductance. No noteworthy effects on systemic
      hemodynamics were observed.

PMID- 1016197
TI  - The role of individual recognition by odors in the social interactions of the
      Mongolian gerbil (Meriones unguiculatus).

PMID- 1016196
TI  - Studies on the regulation of myocardial blood flow in man. I.: Training effects
      on blood flow and metabolism of the healthy heart at rest and during standardized
      heavy exercise.
AB  - In a comparative study 11 athletes and 11 untrained students were investigated at
      rest, of these 6 trained and 5 untrained individuals during exercise as well.
      Myocardial blood flow was measured by the argon method. Myocardial oxygen
      consumption, myocardial substrate uptake of glucose, lactate, and free fatty
      acids and cardiac output were determined by the direct Fick principle. Exercise
      was standardized according to 65% of an individual's maximal oxygen uptake (delta
      VO2 max). Coronary flow reserve was determined by dipyridamole injections. All
      measurements were made during hemodynamic and respiratory steady-state conditions
      with the subject in a supine position. At rest, myocardial blood flow and
      myocardial oxygen consumption were significantly lower in trained subjects
      compared to the untrained ones. These differences were more pronounced during
      heavy exercise. They cannot be explained completely by hemodynamic parameters. -
      During exercise, myocardial substrate uptake shifted to a predominant lactate
      uptake of almost 90% of total substrate uptake. Total substrate uptake as well as
      lactate uptake correlated significantly with myocardial oxygen. - Coronary flow
      reserve was lower in the trained group. It is concluded that the heart muscle of
      a trained individual requires less energy at a given work load than in the
      untrained state.

PMID- 1016198
TI  - A classification of tumor development based on an analysis of enzymes in tissue
      sections of hypernephroid carcinoma in man.
AB  - Sections of hypernephroid carcinoma from 20 cases were investigated for aldolase
      isozymes A and B by a mixed aggregation immuno-cytochemical technique, and for
      the brush border membrane enzymes aminopeptidase and alkaline phosphatase by
      conventional histochemical techniques. It was found that the cases could be
      grouped into four types: type 1 (1 case) contained all 4 enzymes; type 2 (7
      cases) contained all enzymes except aldolase-B; type 3 (7 cases) possessed
      aldolase-A and one brush border membrane enzyme; type 4 (5 cases) contained only
      aldolase-A. The aldolase-A concentration in all tumor cells was higher than that
      in proximal tubule cells, whereas the concentration of the two brush border
      enzymes was lower. In cases tydolase-B and/or higher amounts of the brush border
      enzymes than the surrounding cells. No correlation was observed between clear
      cell and granular cell hypernephroid carcinomas or the invasiveness or the
      nuclear polymorphism of the tumors on the one hand with their enzyme type on the
      other. These histological enzyme analyses suggest that most, if not all,
      hypernephroid carcinomas are derived from kidney proximal tubule cells and that
      the tumor cells then progressively lose aldolase-B, and subsequently the brush
      border enzymes, but at the same time producing more aldolase-A. The presence of
      the enzyme-rich patches suggest different patterns of proliferation and
      differentiation among the tumor cell population. Three tumors other than
      hypernephroid carcinoma were also examined in this way. The results suggest that
      histoenzymological analyses are of general applicability in studies of tumor
      progression. They should also be useful for biopsy and aspiration cytology.

PMID- 1016199
TI  - Quantitative electron microscopic study of capillaries in diabetes mellitus.
AB  - A systematic microscopic examination of all elements of the capillary wall was
      performed on quadriceps muscle biopsies from 9 diabetic patients and 8 controls.
      The capillary basement membrane (CBM) was markedly thicker in diabetics; it
      consisted of several lamellae and contained large vacuoles which were never
      observed in non-diabetic subjects. Large magnifications revealed fibrils in
      greater number and markedly larger in diameter in diabetics, these accounting for
      a considerable volume of the CBM and the adventitia and increased diameter and
      thickness of the capillary wall, without encroaching on the lumen. The
      intracellular fibrils in pericytes and endothelial cells were also larger and
      thicker in diabetic subjects. The prevalence of fibrillar material in the
      vascular disease of diabetes mellitus suggests the importance of research into
      possible measures to arrest fibril formation.

PMID- 1016200
TI  - The significance of DNA flow-through fluorescence cytophotometry for the
      diagnosis of prostate carcinoma.
AB  - Flow-through fluorescence cytophotometric determination of nuclear DNA content
      was employed for the diagnosis of prostate carcinoma. Fine needle aspiration
      biopsy material from the prostate of 220 patients was used for study. A false
      negative rate of 11.4% and a false positive rate of 29.7% were obtained when the
      results of flow-through photometry were compared with those of traditional
      cytodiagnosis. It was found that 4.5% of the specimens were unsuitable for
      cytologic diagnosis and 10.9% for flow-through cytophotometry. False negative DNA
      histograms may be due to two factors: either the number of tumor cells is small
      or there are tumor cells whose nuclear DNA content does not differ from that of a
      normal cell population. False positive findings result from proliferating cells
      in inflammatory activation. Errors in preparation of the material and mechanical
      mistakes, such as cellular clumping and coincidences, are less likely causes. The
      greater percentage of specimens which were inadequate for cytophotometry was due
      to the large number of cells needed for a utilizable flow-through photometric
      histogram. The high rate of false negative and false positive results (11.4% and
      29.7%, respectively) argues against using flow-through photometric nuclear DNA
      determination for the diagnosis of prostate carcinoma.

PMID- 1016201
TI  - [Postmortem demonstration of portal vein collateral circulation (author's
      transl)].
AB  - INTRODUCTION: Postmortem investigation of esophageal varices and the portal
      system is difficult, because veins are collapsed at autopsy. The demonstration of
      varices is possible by illumination of the isolated mucous membrane or by
      puncturing esophageal varices and filing them with different materials. MATERIAL
      AND METHODS: We use a 15% aqueous gelatine solution (if needed with additional
      barium sulfate for x-ray examination) which is supplemented by 40% formaldehyde
      (40 ml in 1 1 gelatine solution). The superior mesenteric vein is catheterized
      and filled by a clyster-pump. RESULTS: The mixture of gelatine and formaldehyde
      hardens within a few minutes. The autopsy is delayed only about half an hour.
      Within this time the portal system is well outlined. This method can show exactly
      the drainage of the portal system into the inferior vena cava. In cases of
      portocaval shunt or of esophageal transsection the result of the operation can be
      verified. The localization of the bleeding source of esophageal varices can be
      demonstrated by escape of the filling mass.

PMID- 1016202
TI  - [Biochemical viewpoints and technic of screw and plate osteosynthesis].

PMID- 1016203
TI  - [Technic of lock nailing with a new targeting device. Analysis of 64 cases of
      surgery].

PMID- 1016204
TI  - [The stabilization of distal radius fragments and ulnar fractures by means of
      Kirschner wires].

PMID- 1016205
TI  - [Talocrural arthrodesis after injuries].

PMID- 1016206
TI  - [Experimental lymphostatic arthropathy].

PMID- 1016207
TI  - [The Lambrinudi method of surgery of the paralytic pointed foot].

PMID- 1016208
TI  - [Problems of etiology, prevention and treatment of juvenile muscular
      torticollis].

PMID- 1016209
TI  - [Traumatic sternum osteitis with substernal abscess].

PMID- 1016210
TI  - [A new pelvic nail].

PMID- 1016211
TI  - [A new drilling device].

PMID- 1016212
TI  - [Evaluation of arterial occlusive disease].
AB  - In giving an opinion on arterial circulation disorders, an arterial occlusion is
      predominant. As a rule, the diagnosis based on anamnestic data, clinical
      examinations and some functional tests causes no difficulties. An angiography
      simplifies the evaluation, but it should be carried out only to distinguish a
      generalized vasculopathy from a local one. The arterial occlusion is a chronic
      and progressive disease with coronary vessels being mainly involved. The muscular
      force of the patient is reduced, local infections and traumatisms menace him thus
      reducing his working capacity. Anticoagulants must often be given continuously,
      the vascular systems of the heart and the brain may be impaired. It is extremely
      difficult to elucidate causal relationships, especially in case of injuries
      suffered during military service. It is the general opinion nowadays that cold
      injuries entail a limited angiitis but no generalized vasculopathy.

PMID- 1016213
TI  - ["Superficial spreading melanoma" within a psoriasis focus as a delayed sequela
      following arsenic therapy for psoriasis].
AB  - After a longlasting psoriasis (25-30 years) and after an arsenotherapy of
      psoriasis per os fifteen years ago an arsenic-caused injury occured with
      formation of a melanoma within the surrounding psoriasis. In examinating
      comparable Moselle vine dressers with late arsenic-caused injuries during the
      years 1972-1975, altogether 1600 examinations, precancerosis, basaliomas, morbus
      Bowen, spinaliomas, and transitional epithelium carcinomas have been found and
      have been histologically confirmed. No melano malignom has been found. Al in
      eleven other cases of vine dressers with arsenic-caused late injuries showing
      keratosis, precancerosis, and basaliomas together with a long-lasting psoriasis
      vulgaris no melano malignom has been found.

PMID- 1016214
TI  - Studies on live attenuated mumps vaccine. II. Follow-up study on the efficacy of
      Biken Vaccine.
AB  - Clinical and serological follow-ups were made on 18 children for 3 years and on
      another 18 children for 4 years, after immunization against mumps by attenuated
      mumps vaccine; Biken vaccine. To evaluate the protective efficacy of the vaccine,
      matched controls were studied during the same period. Serological examinations
      revealed that 77% of the vaccinees and 93% of the controls were infected with
      mumps after close contacts with mumps patients. Regular mumps was contracted by
      88% of the controls, but none of the vaccinees. There was no substantial decrease
      in the antibody titers in unexposed vaccinees after vaccination.

PMID- 1016215
TI  - Antitumor effects of interferon on transplanted tumors in congenitally athymic
      nude mice.

PMID- 1016216
TI  - Effect of hormone treatment on genital herpetic infection in mice.

PMID- 1016217
TI  - Isolation and purification of D-alanyl-meso-2, 6-diaminopimelic acid
      endopeptidase of Streptomyces L-3 enzyme using soluble substrates of known
      chemical structure from Lactobacillus plantarum cell wall digests.
AB  - D-alanyl-meso-2, 6-diaminopimelic acid (D-Alanyl-meso-A2pm) endopeptidase was
      isolated and purified from a crude Streptomyces L-3 enzyme preparation by ion
      exchange chromatography and isoelectric focusing in a density gradient. During
      its purification, its hydrolytic activity was assayed on cell walls of
      Lactobacillus plantarum ATCC 8014 and soluble glycopeptides and peptides, of
      known chemical structures, prepared enzymatically from these cell walls. A
      fraction with an isoelectric point of pH 7.9 cleaved the bond between the
      carboxyl group of the D-alanine residue at the C-terminal in one peptide subunit
      and one of the two amino groups of the A2pm residue in the neighboring peptide
      subunit. Unlike the crude enzyme, the endopeptidase in this fraction showed no N
      acetylmuramyl-L-alanine amidase, A2pm carboxyamide amidase or proteinase(s)
      activity and it was immunologically homogeneous.

PMID- 1016218
TI  - Studies of the cell envelope of Vibrio para-haemolyticus A55: isolation and
      purification of bag-shaped peptidoglycan (murein sacculus).
AB  - The peptidoglycan (PG) component of the envelope of Vibrio parahaemolyticus A55
      was studied in relation to the salt dependency of the organism. A bag-shaped PG
      (murein sacculus) was isolated and purified by digestion of freshly harvested
      intact whole cells with sodium dodecyl sulfate (SDS) and then protease treatment.
      Whole cells lyze in salt-deficient or hypotonic conditions and this can be
      measured by turbidometry. Lysis is prevented by addition of 0.35 M NaCl or
      acidification to below pH 4.5. The isolated PG or murein sacculi did not seem to
      require salt for structural integrity. The PG obtained by the same method from
      subcellular fractions, that is, envelope fractions, prepared either with or
      without NaCl, was extensively fragmented. The main amino acids and amino sugars
      of the murein sacculus were glucosamine, muramic acid, alanine, glutamic acid, 2,
      6-diamnopimelic acid (A2pm) in a molar ratio of 0.4:0.6:1.7:0.9:1.0. A
      polyglucose, which was only degraded by Pseudomonas isoamylase,and poly-beta
      hydroxybutyrate (PHBA) were found in the murein sacculus. The murein sacculus of
      the organism is discussed in comparison with PG of other gram negative bacteria
      and marine or halophilic microorganisms.

PMID- 1016219
TI  - Genetic control of heat sensitivity and activity level of murine arylsulfatase B.
AB  - BALB/c male mice possess twofold higher kidney p-nitrocatechol-SO4 arylsulfatase
      B than do A/HeJ male mice; however, their liver arylsulfatase activities are
      comparable. Twentyfold-purified kidney arylsulfatases B from these two strains
      have similar Michaelis constants, electrophoretic mobilities, pH optima, and
      inhibitor profiles; however, the BALB/c enzyme is more heat stable than the A/HeJ
      enzyme. BALB/c, C3H/HeJ, DBA/2J, and SWR/J mice share an autosomal allele, As-1a,
      which apparently determines the heat-stable arylsulfatase B, while A/HeJ and
      C57BL/6J mice possess the As-1b allele, which determines the heat-sensitive
      enzyme. A second autosomal locus, Asr-1, determines liver arylsulfatase B
      activity. C57BL/6J mice carry the Asr-1a allele, which results in high liver
      activities, while C3H/HeJ mice are homozygous for the low-activity allele, Asr
      1b. Male mice generally have 30-40% higher kidney activities than females;
      however, female kidney arylsulfatase activities rise and actually surpass those
      of males during late pregnancy and lactation.

PMID- 1016220
TI  - The enzymatic deficiency conditioned by the shrunken-1 mutations in maize.
AB  - Evidence is presented to show that the Sh locus specifies sucrose synthetase in
      the developing endosperm of maize. The sh/sh/sh endosperm possesses less than 10%
      sucrose synthetase activity as compared to the normal Sh/sh/sh endosperm. The
      residual enzyme activity in five independently derived mutant genotypes is
      attributable to a protein molecule of different electrophoretic and
      immunochemical specificities that is presumably independent of the sh locus.
      Sucrose synthetase activity in the embryo in both the genotypes is
      electrophoretically indistinguishable from the one present in the mutant
      endosperm. Mutant endosperm has a reduced starch content as compared to the
      normal. This observation constitutes genetic evidence supporting a critical role
      for sucrose synthetase in starch biosynthesis.

PMID- 1016221
TI  - Multiple structural genes for the alpha chain of canine (Canis familiaris)
      hemoglobin.
AB  - There are two forms of the alpha chain of canine hemoglobin differing only at
      residue 130. One form (taualpha) contains threonine at this position, the other
      (Aalpha) contains alanine. Studies of two Labrador dog families strongly support
      the existance of multiple alpha-chain structural genes as the basis of the alpha
      chain heterogeneity. There must be at least one gene locus for Talpha and one for
      Aalpha; the exact number of loci has not been determined. Two other dog breeds,
      the Basenji and the Beagle, also have both Talpha and Aalpha chains.

PMID- 1016222
TI  - Analysis of repetitive DNA in three species of Gossypium.
AB  - The rate of reassociation of denatured DNA was determined for two selected
      diploid species, Gossypium thurberi (D genome) and G. arboreum (A genome), and
      one allotetraploid species, G. hirsutum (AD genome). The relative genome size and
      DNA content of the chromosomes of the diploids were A greater than D.
      Renaturation curves indicated that the differences in genome sizes were due
      primarily to the repetitive DNA content.

PMID- 1016224
TI  - Chromosome number and flavonoid synthesis in Briza L. (Gramineae).
AB  - Following a recent reidentification of the apigenin C-glycosides in diploid Briza
      media, the luteolin C-glycosides were reexamined and three acylated derivatives
      of a luteolin C-glycoside were found. In an attempt to identify the chromosome or
      group of chromosomes responsible for the change in flavonoid synthesis from 4'
      hydroxy- in diploid plants to 3',4'-dihydroxyflavone C-glycosides in
      autotetraploid plants, leaf flavonoids of artificially produced aneuploids of B.
      media were examined. Among these plants three different leaf flavonoid profiles
      were recognized: diploid, tetraploid, and a "modified" tetraploid pattern. All
      the aneuploids with the normal or "modified" tetraploid pattern were trisomic for
      one of the small acrocentric chromosomes. Induced polyploids of other Briza
      species were usually found to have similar flavonoid patterns in the two
      chromosome races. Flavonoid sulfates were found in three South American species
      but are absent from all the European species.

PMID- 1016223
TI  - Allelic expression in intergeneric fox hybrids (Alopex lagopus x Vulpes vulpes).
      I. Comparative electrophoretic studies on blood enzymes and proteins in arctic
      and silver foxes.
AB  - Twenty-seven blood enzymes and proteins, whose structures are presumably
      controlled by at least 33 genes, were assayed in Arctic and silver foxes by
      starch gel electrophoresis. Two types of protein and enzyme electrophoretic
      patterns were distinguished: one exhibiting a single enzyme, the other several
      isozymes. The two fox species were found to differ in seven of the 27 enzymes and
      proteins studied: glucose-6-phosphate dehydrogenase, adenylate kinase,
      erythrocyte carboxylesterase, diaphorase, prealbumin, transferrin, and albumin.
      No differences were established between the species for the other enzymes and
      proteins. The data are interpreted as evidence for the existance of a set of
      enzymes and proteins differentiating the Arctic from the silver fox.

PMID- 1016225
TI  - Identification of wheat (Triticum aestivum L.) chromosomes with genes controlling
      the level of nitrate reductase, nitrite reductase, and acid proteinase using the
      Chinese Spring-Hope substitution lines.
AB  - The levels of nitrate reductase, nitrite reductase, and acid proteinase were
      compared in the primary leaves of 8-day-old wheat seedlings of Chinese Spring,
      Hope, and the 21 disomic substitution lines of Hope in Chinese Spring. Two
      chromosomes, 7B and 7D, were considered to contain genes controlling the level of
      nitrate reductase. Substitution of Hope chromosome 7B caused a highly significant
      increase in the in vitro stability of nitrate reductase. Nitrite reductase
      appeared to be controlled by two major genes, located on chromosomes 4D and 7D,
      and two minor genes, located on chromosomes 3D and 5A. In the case of acid
      proteinase, substitution of chromosome 1D caused a significant reduction in
      enzyme activity.

PMID- 1016226
TI  - Genetic control and distribution of leucine aminopeptidase in the cultivated
      chenopods (Chenopodium) and related weed taxa.
AB  - Isozymes of leucine aminopeptidase (LAP) in leaf tissue of the cultivated
      chenopods (Chenopodium quinoa and C. nuttalliae) and their sympatric weedy
      relatives (C. hircinum and C. berlandieri) can be electrophoretically resolved
      into a sum total of five anodally migrating bands. These are the products of two
      unlinked gene loci which apparently reflect genetic duplication via
      allotetraploidy. Accessions from the Andean and Mexican areas of cultivation are
      characterized by a lack of electrophoretically detectable variation. Andean weed
      and cultigen accessions appear to be genetically identical at both Lap loci, as
      do weed and cultigen material from Mexico. The two cultigens, and their sympatric
      weeds, can be differentiated by variation at the Lap-B locus, whereas they are
      monomorphic at Lap-A. This locus is, however, highly polymorphic in weedy C.
      berlandieri populations of western North America.

PMID- 1016227
TI  - Correlation between structural variation and activity of murine kidney beta
      galactosidase: implications for genetic control.
AB  - Two closely linked regulatory genes have been reported to control activity levels
      of beta-galactosidases in murine tissues. The specific effects of these genes on
      murine glycolipid metabolism have not been elucidated. A/HeJ kidney 4
      methylumbelliferyl-beta-galactosidase exhibited lower thermostability than the
      corresponding C57BL/6J and SWR/J enzymes. This altered response to heat
      segregated with the Bgsh allele among progeny derived from backcrosses of F1
      (A/HeJ; SWR/J) mice to the respective parental strains. Restriction of the heat
      sensitive A/HeJ beta-galactosidase to kidney tissue suggests that it is not
      determined by the Bgs locus, since the latter appears to be expressed in all
      tissues. More likely, the Bgs region of chromosome 9 contains a gene cluster
      consisting of a number of regulatory and structural loci. The proposed structural
      genes share affinity for the artificial substrates commonly employed for their
      assay but may differ in their relative affinities for glycosphingolipid
      substrates. Presence of the Bgsh allele results in an increase of kidney GM1
      ganglioside-beta-galactosidase; however, galactosylceramide-beta-galactosidase
      appears unaffected by this allele.

PMID- 1016228
TI  - On the detection of functional and structural enzyme mutants by coordinated
      affinity chromatography and isoelectric focusing.
AB  - A method of studying structural and functional heterogeneity of enzymes has been
      developed and tested on chymotrypsin. The enzyme, prepared from single mouse
      pancreata, has been fractionated with respect to function and charge content by a
      combination of affinity chromatography and isoelectric focusing. By comparing
      chymotrypsin isolated from isogenic strains, chymotrypsinogen of strains A/Sn and
      NZB was found to be genetically heterogeneous, thus not revealed as different
      chymotrypsin forms of a single zymogen. Chymotrypsinogen originating from two
      loci was investigated, and structural and functional differences of the
      corresponding enzymes were determined. At both loci, structural allelomorphism
      was indicated. At one locus, the structural heterogeneity was also found to be
      reflected in functional heterogeneity of the corresponding enzymes. By mating the
      two strains and fractionating the enzyme of the cross, the differences were shown
      to be inherited.

PMID- 1016229
TI  - An investigation of the products of 53 gene loci in three species of wild
      Canidae: Canis lupus, Canis latrans, and Canis familiaris.
AB  - This article describes an investigation of inter- and intraspecific variation in
      three small populations of wild Canidae-wolf, coyote, and dingo. The products of
      53 gene loci were examined. Very little interspecies variation was observed, but
      the level of intraspecific variation was compatible with that found in man.

PMID- 1016230
TI  - Gene action in fish of tetraploid origin. V. Cellular RNA and protein content and
      enzyme activities in cyprinid, clupeoid, and salmonoid species.
AB  - The ratio of cellular RNA and protein content is about 1:1 between
      phylogenetically diploid and tetraploid species of the teleost family Cyprinidae,
      but is roughly in proportion to ploidy in species of the teleost order
      Isospondyli. Enzyme activities do not unequivocally comply with this scheme.
      These findings are discussed in view of the hypothesis that a regulatory
      mechanism which reduces genic activity has evolved in the tetraploid cyprinids
      but not in the tetraploid species of the order Isopondyli.

PMID- 1016231
TI  - Genetic study of pancreatic proteinase in mice (Mus musculus): linkage of the Prt
      2 locus on chromosome 8.
AB  - The Prt-2 locus is linked with Es-1 and Es-2 loci on chromosome 8 (linkage group
      XVIII). Recombination frequencies were 8.2% between Es-1 and Es-2 12.7% between
      Es-1 and Prt-2, and 4.5% between Es-2 and Prt-2. From these data, the map
      position of Prt-2 has been estimated on chromosome 8. The Prt-1 and Prt-3 loci,
      which are linked very closely on the same chromosome, were not determined.

PMID- 1016232
TI  - Demonstration of a new mammalian isoleucine catabolic pathway yielding an Rseries
      of metabolites.
AB  - 1. Normal human urine contains small amounts (less than 4 mg/g of creatinine) of
      2-ethylhydracrylic acid, formed, we believe, by a previously undisclosed
      endogenous catabolic pathway for the oxidation of a newly described series of R
      metabolites of isoleucine. 2. Urinary excretion of 2-ethylhydracrylic acid is
      variably increased in defects of isoleucine oxidation at distal steps in the
      catabolic pathway (3-oxoacyl-CoA thiolase deficiency and methylmalonyl-CoA mutase
      deficiency) and is diminished when proximal steps of the oxidative pathway are
      blocked as in branched-chain oxo acid decarboxylase deficiency ('maple-syrup
      urine' disease). 3. Precursors of R-pathway metabolites [R(-)-2-methylbutyrate
      and 2-ethylacrylate ] lead to increased 2-ethylhydracrylate excretion in the
      mammal(rat, rabbit and dog); the corresponding S metabolites [S(+)-2
      methylbutyric acid and tiglic acid ], when given in equimolar amounts, have
      little effect on its excretion, suggesting that little or no interconversion
      between S and R metabolites occurs in vivo. 4. Studies with 2H-labelled
      precursors indicate that conversion of R 2-methylbutyrate into 2-ethylhydracrylic
      acid occurs by a direct pathway (apparently via 2-ethylacrylic acid). 5. The
      further oxidation of 2-ethylhydracrylic acid to ethylmalonic acid was
      demonstrated, and may be analogous to S-metabolite oxidation via methyl malonate.
      6. Valine metabolites do not interact with the R=isoleucine pathway under the
      conditions of these experiments in vivo.

PMID- 1016233
TI  - Radioactive labelling of ribosomal proteins with reductive alkylation and its use
      in studying ribosome-cytosol interactions.
AB  - Mouse brain ribosomes were radioactively labelled by a cell-free reductive
      alkylation reaction with NaBH4 and [14C]formaldehyde. The radioactivity was
      largely associated with ribosomal proteins, but little, if any, of the rRNA was
      radioactive after the alkylation procedure. Both ribosomal structural proteins
      and loosely associated components were successfully labelled by this procedure.
      The sedimentation properties of the ribosomes were unaltered and their ability to
      carry out poly(U)-directed protein synthesis, although decreased, was largely
      retained. Incubation of 14C-labelled ribosomes with brain cytosol resulted in a
      17% loss of radioactivity, although treatment of the ribosomes with 1.0 m-KCl to
      remove the loosely associated factors rendered the ribonucleoprotein particles
      resistant to cytosol effects. The ribosome-cytosol interactions did not appear to
      be related to an exchange process, since the released radioactivity was largely
      degraded to acid-soluble material. In addition, the incubation of native
      ribosomes with brain cytosol resulted in an almost complete loss in the ability
      of the ribosomes to participate in cell-free protein synthesis.

PMID- 1016234
TI  - The effect of calcium ions on testosterone production in Leydig cells from rat
      testis.
AB  - Leydig-cell suspensions, prepared from rat testes, were incubated with different
      amounts of Ca2+ with and without added luteinizing hormone. The basal
      testosterone production in the absence of luteinizing hormone was unaffected by
      the Ca2+ concentration in the incubation medium. The luteinizing hormone
      stimulated testosterone production, however, was progressively decreased in the
      absence of Ca2+ to one-third of that with 2.50 mM-Ca2+. This decrease in
      luteinizing hormone-stimulated testosterone production was independent of the
      different concentrations of luteinizing hormone (0-10mug/ml) used and could be
      restored by the addition of Ca2+ to the incubation medium. The restoration of the
      stimulation was achieved within 30 min after the addition of Ca2+ to the medium.
      Activation of cyclic AMP-dependent protein kinase by luteinizing hormone was not
      decreased by omission of Ca2+ from the incubation medium, suggesting that Ca2+
      may be involved in steroidogenesis at a stage beyond the luteinizing hormone
      receptor-adenylate cyclase-protein kinase system.

PMID- 1016235
TI  - Total plasmalogens and O-(acylalkylglycerophosphoryl) ethanolamine from labelled
      hexadecanol and palmitate during hypoxia and anoxia in rat heart.
AB  - By the use of the Langendorff technique, surviving isolated rat hearts were
      perfused with [1-14 C] palmitate, [1-14C] hexadecanol or [1-14C,1-3H] hexadecanol
      under normal or anoxic conditions. After perfusion for 30min with either
      precursor, when oxygenated or in an hypoxic condition, or when 1mM-KCN was
      included in the system, the heart tissues showed no significant chemical changes
      in their content of total lipids, total phospholipids or total ethanolamine
      containing phospholipids. Changes were observed in the ratio of alkyl-to alk-1
      enyl-glycerophosphorylethanolamine in the tissue perfused with N2+CO1 plus CN-. A
      slight increase from 4.0+/-0.3 to 4.9+/-0.2% in alkyl derivatives and a decrease
      from 11.2+/-0.4 to 9.4+/-0.3% in alk-1-enyl derivatives was observed. The
      incorporation of the [14C] palmitate and the [14C] hexadecanol into the recovered
      phospholipids and plasmalogens was severely decreased in the tissues perfused
      with CN-: in the hypoxic state only a mild inhibition was observed compared with
      the oxygenated systems. Considerable 3H from [1-14C, 1-3H] hexadecanol was
      retained (25-35%) in the alk-1-enylether chains of plasmalogens under both the
      oxygenated conditions and with CN-, suggesting that the same mechanism of
      incorporation is operational at high or low O2 concentrations. The results are
      consistent with an O2-dependent, CN-sensitive step in the biosynthesis of
      plasmalogens in the rat heart.

PMID- 1016236
TI  - Intranuclear maturation pathways of rat liver ribosomal ribonucleic acids.
AB  - The maturation of pre-rRNA (precursor to rRNA)in liver nuclei is studied by
      agar/ureagel electrophoresis, kinetics of labelling in vivo with [14C] orotate
      and electron-microscopic observation of secondary structure of RNA molecules. (1)
      Processing starts from primary pre-rRNA molecules with average mol. wt.
      4.6X10(6)(45S) containing the segments of both 28S and 18S rRNA. These molecules
      form a heterogeneous peak on electrophoresis. The 28S rRNA segment is homogeneous
      in its secondary structure. However, the large transcribed spacer segment
      (presumably at the 5'-end) is heterogeneous in size and secondary structure. A
      minor early labelled RNA component with mol.wt. about 5.8X10(6) is reproducibly
      found, but its role as a pre-rRNA species remains to be determined. (2) The
      following intermediate pre-rRNA species are identified: 3.25X10(6) mol.wt.(41S),
      a precursor common to both mature rRNA species ; 2.60X10(6)(36S) and
      2.15X10(6)(32S) precursors to 28S rRNA; 1.05X10(6) (21S) precursor to 18S rRNA.
      The pre-rRNA molecules in rat liver are identical in size and secondary structure
      with those observed in other mammalian cells. These results suggest that the
      endonuclease-cleavage sites along the pre-rRNA chain are identical in all
      mammalian cells. (3) Labelling kinetics and the simultaneous existence of both
      36S and 21S pre-rRNA reveal that processing of primary pre-rRNA in adult rat
      liver occurs simultaneously by at least two major pathways: (i) 45S leads to 41S
      leads to 32S+21S leads to 28S+18S rRNA and (ii) 45S leads to 41S leads to 36S+18S
      leads to 32S leads to 28S rRNA. The two pathways differ by the temporal sequence
      of endonuclease attack along the 41 S pre-rRNA chain. A minor fraction
      (mol.wt.2.9X10(6), 39S) is identified as most likely originating by a direct
      split of 28S rRNA from 45S pre-rRNA. These results show that in liver
      considerable flexibility exists in the order of cleavage of pre-rRNA molecules
      during processing.

PMID- 1016237
TI  - Re-activation of the peptidyltransferase centre of rabbit reticulocyte ribosomes
      after inactivation by exposure to low concentrations of magnesium ion.
AB  - 1. The larger subrivosomal particles of rabbit reticulocytes retained full
      activity in the puromycin reaction and in poly(U)-directed polyphenylalanine
      synthesis after 4h at 0 degrees C when buffered 0.5M-NH4Cl/10-30mM-MgCl2 was the
      solvent. 2. Activity in the puromycin reaction was diminished to approx 10% after
      15-30 min at 0 degrees C when the concentration of MgCl2 was lowered to 2mM. 3.
      Activity was not restored when the concentration of MgCl2 was raised from 2mM to
      10-30 mM at 0 degrees C. However, activity was recovered as measured by both
      assay systems when the ribosome fraction was heated to 37 degrees C at the higher
      concentrations of MgCl2. 4. Recovery of activity was noted during the course of
      the polyphenylalanine synthesis in 50 mM-KCl/5mM-MgCl2/25mM-Tris/HCl, pH 7.6, at
      37 degrees C. Re-activation was slow at 20 degrees C and below. 5. No more than
      about 5% of the protein moiety of the subparticle was lost in 0.5M-NH4Cl on
      decreasing MgCl2 concentration from 10mM to 2mM. No proteins were detected in the
      supernatant fractions by gel electrophoresis after ribosomes were separated by
      differential centrifugation. The supernatant fraction was not essential for the
      recovery of activity. However, at higher (e.g. 1M) concentrations of NH4Cl,
      proteins were split from the subparticle. 6. The loss and regain of activity
      found on lowering and restoring the concentration of MgCl2 at 0.5M-NH4Cl appears
      to arise from a conformational change that does not seem to be associated with a
      loss and regain of particular proteins. 7. A 2% decrease in E260 was noticed when
      the concentration of Mg2+ was restored, and the change in the spectrum indicated
      a net increase of approx. 100A-U base-pairs per subribosomal particle. 8. When
      the concentration of Mg2+ was restored, S20,W of the subparticle remained at 52+/
      1S until the sample was incubated at 37 degrees C when S20,W increased to 56 +/-
      1S compared with the value of 58 +/- 1S for the subparticle as originally
      isolated.

PMID- 1016238
TI  - Reassembly of the peptidyltransferase centre of larger subparticles of rabbit
      reticulocyte ribosomes from a core-particle and split-protein fraction.
AB  - We report the reconstruction, from a core-particle and split-protein fraction, of
      the larger subribosomal particle of rabbit reticulocytes. The reassembled
      particle was active in polyphenylalanine synthesis and in the puromycin reaction.
      The core-particles and split-protein fractions were obtained by treatment of the
      larger subparticle with salt solutions containing NH4+ and Mg2+ in the molar
      ratio 40:1 over the range 2.25-2.75 M-NH4Cl/56-69mM-MgCl2 at 0 degrees C. This
      treatment led to the loss of about eight proteins (approx. 17% of the protein
      moiety), which were found wholly or largely in the split-protein fraction as
      shown by two-dimensional gel electrophoresis. The core particle retained 5S rRNA
      and had much decreased (no more than 10% of control) ability to function in the
      puromycin reaction or in poly (U)-directed polyphenylalanine synthesis. Activity
      was recovered when the recombined core-particle and split-protein fractions were
      dialysed overnight at 4 degrees C against 0.3M-NH4Cl/15mM-MgCl2/1mM
      dithiothreitol/15% (v/v) glycerol/20mM-Tris/HCl, pH 7.6, and then heated for 1 h
      at 37 degreesEES C. The recovery was 40-80% of the original activity. Raising the
      concentration of MgCL2 to 300 mM in 2.5 M-NH4CL led to the removal of seven
      rather than eight proteins, and the core particle remained active in the
      puromycin reaction. We infer that the protein retained by raising the
      concentration of Mg2+ is an essential component of the peptidyltransferase centre
      of the ribosome.

PMID- 1016239
TI  - Developmental changes in purine phosphoribosyltransferases in human and rat
      tissues.
AB  - 1. The hypoxanthine/guanine and adenine phosphoribosyltransferase activities in a
      wide variety of human tissues were studied during their growth and development
      from foetal life onward. A wide range of activities develop after birth, with
      especially high values in the central nervous system and testes. 2. Postnatal
      development of hypoxanthine/guanine phosphoribosyltransferase was also defined in
      the rat. Although there were increases in the central nervous system and testes,
      there was also a rise in activity in the liver, which was less marked in man. 3.
      A sensitive radiochemical assay method, using dTTP to inhibit 5'-nucleotidase
      activity, suitable for tissue extracts, was developed. 4. No definite evidence of
      the existence of tissue-specific isoenzymes of hypoxanthine/guanine or adenine
      phosphoribosyltransferase was found. Hypoxanthine/guanine
      phosphoribosyltransferase in testes, however, had a significantly different
      thermal-denaturation rate constant. 5. The findings are discussed in an attempt
      to relate activity of hypoxanthine/guanine phosphoribosyltransferase to
      biological function. Growth as well as some developmental changes appear to be
      related to increase in the activity of this enzyme.

PMID- 1016240
TI  - Degradation of hepatic zinc-thionein after parenteral zinc administration.
AB  - A low-molecular-weight protein, zinc-thionein, a metallothionein, was implicated
      as having a regulatory function in zinc metabolism. The half-life (t 1/2) of
      hepatic zinc-thionein was determined by pulse-labelling with either L-[35S]
      cystine and/or 65Zn. In two experiments with L-[35S]cystine, the t 1/2 of zinc
      thionein was 18h and 19h. Most of the soluble 35S-labelled hepatic proteins had a
      t 1/2 of 4 days. The t 1/2 of zinc-thionein calculated by using 65Zn was 20h. The
      close similarity between the calculated and measured t 1/2 values for zinc
      thionein suggests that release of Zn2+ from zinc-thionein probably occurs
      simultaneously with degradation of the protein moiety.

PMID- 1016241
TI  - Tryptophan concentrations in rat brain. Failure to correlate with free serum
      tryptophan or its ratio to the sum of other serum neutral amino acids.
AB  - Groups of rats were deprived of food overnight and then given free access to
      diets designed to raise (carbohydrate) or lower (carbohydrate and large neutral
      amino acids) brain tryptophan concentrations. Similar diets were supplemented
      with 40% fat and fed to other groups. All animals were killed 2h after food
      presentation. Sera from animals fed carbohydrate plus fat contained 2.5 times as
      much free tryptophan concentrations did not differ. Similarly, sera from rats fed
      on carbohydrate, large neutral amino acids, and 40% fat contained 5 times as much
      free tryptophan as those from rats given this meal without fat, but brain
      tryptophan concentrations increased by only 26%. Correlations were made between
      brain tryptophan and (1) free serum tryptophan, (2) the ratio of free serum
      tryptophan to the sum of the other large neutral amino acids in serum that
      compete with it for uptake into the brain, (3) total serum tryptophan or (4) the
      ratio of total serum tryptophan to the sum of its circulating competitors. The r
      values for correlations (3) and (4) (i.e. those involving total serum tryptophan)
      were appreciably higher than those for correlations (1) and (2). Brain tyrosine
      concentrations also were found to correlate well with the ratio of serum tyrosine
      to the sum of its competitors. Competition for uptake into the brain among large
      neutral amino acids (represented here by serum ratios) thus appears to determine
      the changes in the brain concentrations of these amino acids under physiological
      conditions(i.e. after food consumption). Total, not free, serum tryptophan is the
      relevant index for predicting brain tryptophan concentrations.

PMID- 1016242
TI  - A quantitative study of pinocytosis and lysosome function in experimentally
      induced lysosomal storage.
AB  - The highly pinocytic epithelial cells of the visceral yolk sac from 17.5-day rat
      conceptuses were used as a model in which to induce engorgement of the vacuolar
      system by direct accumulation of substances that are not hydrolysed by lysosomal
      enzymes. The ultra-structural appearances of these cells in pregnant animals that
      24-48h before had received intraperitoneal injections of Triton WR-1339,
      polyvinylpyrrolidone, dextran or sucrose revealed gross abnormalities that were
      confined to the vacuolar system; in comparison with normal tissue the number, and
      in some cases the size, of vacuoles was increased, leading to close packing
      within the apical cytoplasm and distortion of the normal rounded shape. By
      culturing yolk sacs in vitro, rates of ingestion of 125I-labelled
      polyvinylpyrrolidone and of 125I-labelled bovine serum albumin were determined,
      together with the rate of digestion of the labelled protein. The rates of
      exocytosis of 125I-labelled polyvinylpyrrolidone and of lysosomal enzymes were
      also determined. No significant differences between normal and highly vacuolated
      tissues were found. Apparently marked vacuolation of these cells by these agents
      is without significant effect on pinocytosis, exocytosis or intralysosomal
      proteolysis.

PMID- 1016243
TI  - Latency of some glycosidases of rat liver lysosomes.
AB  - The latency of the alpha-glucosidase activity of intact rat liver lysosomes was
      studied by using four substrates (glycogen, maltose, p-nitrophenyl, alpha
      glucoside, alpha-fluoroglucoside) at a range of substrate concentrations. The
      results indicate that the entire lysosome population is impermeable to glycogen
      and maltose, but a proportion of lysosomes are permeable to alpha-fluoroglucoside
      and a still higher proportion permeable to p-nitrophenyl alpha-glucoside.
      Incubation at 37 degrees C in an osmotically protected buffer of of pH 5.0 caused
      lysosomes to become permeable to previously impermeant substrates and ultimately
      to release their alpha-glucosidase into the medium. The latencies of lysosomal
      beta-glucosidase and beta-galactosidase were examined by using p-nitrophenyl beta
      glucoside and beta-galactoside as substrates. The results indicate permeability
      properties to these substrates similar to that to p-nitrophenyl alpha-glucoside.
      On incubation in an osmotically protected buffer of pH 5, lysosomes progressively
      released their beta-galactosidase in soluble form, but beta-glucosidase remained
      attached to sedimentable material. Lysosomal beta-glucosidase was inhibited by
      0.1% Triton X-100; alpha-glucosidase and beta-galactosidase were not inhibited.

PMID- 1016244
TI  - Effect of L-azetidine-2-carboxylic acid on glycosylations of collagen in chick
      embryo tendon cells.
AB  - The glycosylations of hydroxylysine during collagen biosynthesis in isolated
      chick-embryo tendon cells were studied by using pulse-chase labelling experiments
      with [14C]-lysine. The hydroxylation of lysine and the glycosylations of
      hydroxylysine continued after a 5 min pulse label for up to about 10 min during
      the chase period. These data differ from those obtained previously in isolated
      chick-embryo cartilage cells, in which, after a similar 5 min pulse label, these
      reactions continued during the chase period for up to about 20 min. The collagen
      synthesized by the isolated chick-embryo tendon cells differed markedly from the
      type I collagen of adult tissues in its degree of hydroxylation of lysine
      residues and glycosylations of hydroxylysine residues. When the isolated tendon
      cells were incubated in the presence of L-azetidine-2-carboxylic acid, the degree
      of glycosylations of hydroxylysine during the first 10 min of the chase period
      was identical with that in cells incubated without thcarboxylic acid for at least
      60 min, whereas no additional glycosylations took place in the control cells
      after the 10 min time-point. As a consequence, the collagen synthesized in the
      presence of this compound contained more carbohydrate than did the collagen
      synthesized by the control cells. Additional experiments indicated that azetidine
      2-carboxylic acid did not increase the collagen glycosyltransferase activities in
      the tendon cells or the rate of glycosylation reactions when added directly to
      the enzyme incubation mixture. Control experiments with colchicine indicated that
      the delay in the rate of collagen secretion, which was observed in the presence
      of azetidine-2-carboxylic acid, did not in itself affect the degree of
      glycosylations of collagen. The results thus suggest that the increased
      glycosylations were due to inhibition of the collagen triple-helix formation,
      which is known to occur in the presence of azetidine-2-carboxylic acid.

PMID- 1016245
TI  - Platelet-aggregating activity of type I and type III collagens from human aorta
      and chicken skin.
AB  - Human or chicken type III collagen dissolved in 0.1 M-acetic acid was much more
      potent than type I collagen at inducing platelet aggregation. After incubation in
      0.38M-Na2HPO4 to promote fibrillogenesis, the platelet-aggregating activity of
      both collagen types increased, and type I was then virtually equiactive with type
      III. Preincubation in cell-free plasma increased the activity of chicken but not
      that of human collagen. The platelet-aggregating activity of type III collagen
      did not appear to depend on the integrity of the intrachain disulphide bonds.

PMID- 1016246
TI  - Effect of maternal ethanol consumption on foetal and neonatal rat hepatic protein
      synthesis.
AB  - Effects of maternal ethanol consumption were investigated on the rates of protein
      synthehsis by livers of foetal and neonatal rats both in vivo and in vitro, and
      on the activities of enzymes involved in protein synthesis and degradation. The
      rates of general protein synthesis by ribosomes in vitro studied by measuring the
      incorporation of [14C]leucine into ribosomal protein showed that maternal ethanol
      consumption resulted in an inhibition of the rates of protein synthesis by both
      foetal and neonatal livers from the ethanol-fed group. The rates of incorporation
      of intravenously injected [14C]leucine into hepatic proteins were also
      significantly lower in the foetal, neonatal and adult livers from the ethanol-fed
      group. Incubation of adult-rat liver slices with ethanol resulted in an
      inhibition of the incorporation of [14C]leucine into hepatic proteins; however,
      this effect was not observed in the foetal liver slices. This effect of
      externally added ethanol was at least partially prevented by the addition of
      pyrazole to the adult liver slices. Pyrazole addition to foetal liver slices was
      without significant effect on the rates of protein synthesis. Cross-mixing
      experiments showed that the capacity of both hepatic ribosomes and pH5 enzyme
      fractions to synthesize proteins was decreased in the foetal liver from the
      ethanol-fed group. Maternal ethanol consumption resulted in a decrease in hepatic
      total RNA content, RNA/DNA ratio and ribosomal protein content in the foetal
      liver. Foetal hepatic DNA content was not significantly affected. Ethanol
      consumption resulted in a significant decrease in proteolytic activity and the
      activity of tryptophan oxygenase in the foetal, neonatal and adult livers. It is
      possible that the mechanisms of inhibition of protein synthesis observed here in
      the foetal liver after maternal ethanol consumption may be responsible for at
      least some of the changes observed in 'foetal alcohol syndrome'.

PMID- 1016247
TI  - A proposed sequence of hormones controlling the induction of luteal 20alpha
      hydroxy steroid dehydrogenase and progesterone withdrawal in the late-pregnant
      rat.
AB  - 1. The previously reported induction of luteal 20alpha-hydroxy steroid
      dehydrogenase by administration of aminoglutethimide to late-pregnant rats was
      shown to be unaffected by prior removal of the foetuses. Aminoglutethimide
      therefore does not act via the foetuses in this context. 2. The ability of
      injected oestrogen to prevent the above induction was lost by delaying the
      injection for 12h after aminoglutethimide, although the increase in enzyme
      activity begins only after 24h. 3. Induction of 20alpha-hydroxy steroid
      dehydrogenase by foetoplacental removal on day 18 of pregnancy was inhibited by
      human choriogonadotropin, lutropin (luteinizing hormone) and pregnant-mare serum
      gonadotropin, but not by somatotropin (growth hormone), thyrotropin or
      follitropin (follicle-stimulating hormone) 4. Indomethacin blocked the normal
      induction of 20alpha-hydroxy steroid dehydrogenase in late pregnancy and that
      caused by aminoglutethimide. It partially blocked that caused by human
      choriogonadotropin given on days 19-20 and that caused by 2-bromo-alpha
      ergocryptine on days 5-6, but failed to block that caused by human
      choriogonadotropin on days 15-16 or by foetoplacental removal on day 18 of
      pregnancy. 5. These findings, and the control of progesterone synthesis in late
      pregnancy, are interpreted in terms of a sequence of hormonal or enzymic
      syntheses, each of which is inhibited by the product of the preceding synthesis.

PMID- 1016248
TI  - The glycerol phosphate, dihydroxyacetone phosphate and monoacylglycerol pathways
      of glycerolipid synthesis in rat adipose-tissue homogenates.
AB  - 1. Fat-free homogenates from the epididymal fat-pads of rats were used to measure
      the rate of palmitate esterification with different substrates. The effectiveness
      of the acyl acceptors decreased in the order glycerol phosphate, dihydroxyacetone
      phosphate, 2-octadecenyl-glycerol and 2-hexadecylglycerol. 2. Glycerol phosphate
      and dihydroxyacetone phosphate inhibited their rates of esterification in a
      mutually competitive manner. 3. The esterification of glycerol phosphate was also
      inhibited in a partially competitive manner by 2-octadecenylglycerol and to a
      lesser extent by 2-hexadecylglycerol. However, glycerol phosphate did not inhibit
      the esterification of 2-octadecenylglycerol. 4. The esterification of
      dihydroxyacetone phosphate and 2-hexadecylglycerol was more sensitive to
      inhibition by clofenapate than was that of glycerol phosphate. Norfenfluramine
      was more effective in inhibiting the esterification of 2-hexadecylglycerol than
      that of glycerol phosphate or dihydroxyacetone phosphate. 5 It is concluded that
      rat adipose tissue can synthesize glycerolipids by three independent routes.

PMID- 1016249
TI  - The effects of diet on the esterification of glycerol phosphate, dihydroxyacetone
      phosphate and 2-hexadecylglycerol by homogenates of rat adipose tissue.
AB  - 1. Male rats were fed for 5 weeks after weaning on a diet containing (by weight)
      59% of starch or on diets that contained 39% of starch and 20% of either sucrose,
      beef tallow or corn oil. 2. The rats fed on the beef tallow consumed more energy
      than did the rats fed on the starch and sucrose diets. The rats fed on the corn
      oil drank less water than did the other groups of rats. 3. There were no
      significant differences between the four groups in terms of body-weight gain,
      epididymal-fat-pad weight and in the size, number and triacylglycerol content of
      the adipocytes in the fat-pads. 4. There was a significant correlation (P less
      than 0.001) between the activities of glycerol phosphate acyltransferase and
      monoacylglycerol acyltransferase in individual rats. Both of these activities
      were highest in the group fed on the high-starch diet and both correlated with
      the consumption of glucose by individual rats in the four groups. 5. The
      percentage of glycerol phosphate converted into diacylglycerol and
      triacylglycerol was positively correlated with the mean diameters, surface area
      and triacylglycerol content of the adipocytes for individual rats and was greates
      in the sucrose-fed rats. 6. The specific activity of dihydroxyacetone phosphate
      acyltransferase was highest in the rats fed on beef tallow. This activity was
      positively correlated with the energy intake for all dietary groups over the 5
      week feeding period. 7. The results are discussed in terms of the functions of
      the three routes of glycerolipid synthesis in adipose tissue.

PMID- 1016250
TI  - Uptake and effects of copper in rat liver mitochondria.
AB  - The rate and extent of Cu2+ uptake by rat liver mitochondria was measured under
      various conditions. 1. The uptake is both greater and faster without an energy
      supply. 2. The uptake, when occuring in ionic media, has a biphasic character,
      that is it always slows down after an initial burst, and then re-accelerates. 3.
      Uptake of Cu2+ in the presence of energy initiates K+ uptake from K+-containing
      media with accompanying swelling and respiratory stimulation. Depending on the
      amounts of Cu2+ added and the K+ concentration, an inhibition of respiration
      later ensues. 4. Chelation of the Cu2+ by substrates (notably glutamate)
      decreases the effects. 5. Prior exposure to Cu2+ decreases or prevents energy
      dependent Ca2+ uptake.

PMID- 1016251
TI  - Orotate decreases the inhibitory effect of ethanol on galactose elimination in
      the perfused rat liver.
AB  - 1. The galactose-elimination rate in perfused livers from starved rats was
      decreased in the presence of ethanol (2-28mM) to one-third of the control values.
      Orotate injections partly reversed the effect of ethanol, so that the galactose
      elimination rate was about two-thirds of the control values. Orotate alone had no
      effect on the galactose-elimination rate. 2. Ethanol increased [galactose 1
      phosphate] and [UDP-galactose], and decreased (UDP-glucose] and [UTP], both with
      and without orotate. Orotate increased [UTP], [UDP-galactose], both with and
      without ethanol. The increase of [galactose 1-phosphate] in the presence of
      ethanol was inhibited by orotate. Orotate alone had no appreciable effect on
      [galactose 1-phosphate]. 3. Both the effect of ethanol and that of orotate on the
      galactose-elimination rate can be accounted for by assuming inhibition of
      galactokinase by galactose 1-phosphate with Ki about 0.2mM, the inhibition being
      either non-competitive or uncompetitive. 4. The primary effect of ethanol seems
      to be inhibition of UDP-glucose epimerase (EC 5.1.3.2), followed by accumulation
      of UDP-galactose, trapping of UDP-glucose and increase of [galactose 1
      phosphate]. Orotate decreased the effect of ethanol, probably by increasing [UDP
      glucose].

PMID- 1016252
TI  - Ribonucleic acid synthesis in rabbit erythroid cells.
AB  - Kinetic studies on the synthesis of RNA in mature bone-marrow erythroid cells
      from rabbits were made by measuring the incorporation of [2-3H]adenosine into the
      ATP pool and RNA over periods up to 8h. By use of equations to fit the pool
      specific radioactivity and an equation using the same type of pool to generate
      the rate of linear DNA synthesis, good agreement between the pool parameters is
      found, provided that the ATP pool is measured in whole cell extracts, and
      assuming that the dATP and ATP pools equilibrate rapidly. RNA-synthesis rates
      were measured by using curve fits to equations developed by using the pool
      specific-radioactivity curves. The rate of synthesis of poly(A)-containing RNA
      varied in three experiments from 90 to 220mol/min per cell, with half-life of
      nuclear processing of 12-22 min with a mean of 16 min. Ribosomal RNA is
      synthesized at a rate of 70-200 mol/min per cell with an average half-life of
      nuclear processing of 37 min for the 18S RNA and 214 min for the 28S RNA. When
      the stable rRNA components are subtracted from the nRNA synthesis, the rate of
      nRNA synthesis is between 2 and 6fg/min per cell with an average half-life of
      degradation of 27 min. The rate of synthesis of poly(A)-containing RNA is 1.5
      3.5% of the RNA-synthesis rates. These rates are compared with the RNA-synthesis
      rates found in L cells and concentrations of globin mRNA found in various
      erythroid-cell preparations.

PMID- 1016253
TI  - Microbiological degradation of bile acids. Nitrogenous hexahydroindane
      derivatives formed from cholic acid by Streptomyces rubescens.
AB  - The metabolism of cholic acid (I) by Streptomyces rubescens was investigated.
      This organism effected ring A cleavage, side-chain shortening and amide bond
      formation and gave the following metabolites: (4R)-4-[4alpha-(2-carboxyethyl)
      3aalpha-hexahydro-7abeta-methyl-5-oxoindan-1 beta-yl]valeric acid (IIa) and its
      mono-amide (valeramide) (IIb); and 2,3,4,6, 6abeta,7,8,9,9aalpha,9bbeta-decahydro
      6abeta-methyl-1H-cyclopenta[f]quinoline-3,7-dione(IIIe)and its homologues with
      the beta-oriented side chains, valeric acid, valeramide, butanone and propionic
      acid, in the place of the oxo group at C-7, i.e.compounds (IIIa), (IIIb), (IIIc)
      and (IIId) respectively. All the nitrogenous metabolites were new compounds, and
      their structures were established by partial synthesis except for the metabolite
      (IIIc). The mechanism of formation of these metabolites is considered. A
      degradative pathway of cholic acid (I) into the metabolites is also tentatively
      proposed.

PMID- 1016254
TI  - Microbiological degradation of bile acids. The conjugation of a certain cholic
      acid metabolite with amino acids in Corynebacterium equi.
AB  - 1. (4R)-4[4alpha-(2-Carboxyethyl)-3aalpha-hexahydro-7abeta-methyl-5-oxoindan
      1beta-yl]valeric acid (II) could not be utilized by Arthrobacter simplex, even
      though the acid was one of the metabolites formed from cholic acid (I) by this
      organism. Therefore the further degradation of the acid (II) by Corynebacterium
      equi was investigated to identify the intermediates involved in the cholic acid
      degradation. 2. The organism, cultured in a medium containing the acid (II) as
      the sole source of carbon, produced unexpected metabolites, the conjugates of
      this original acid (II) with amino acids or their derivatives, although the yield
      was very low. These new metabolites were isolated and identified by chemical
      synthesis as the Na-((4R)-4-[4alpha-(2-carboxyethyl)-3a alpha-hexahydro-7a beta
      methyl-5-oxoindan-1 beta-yl]-valeryl) derivatives of L-alanine, glutamic acid, O
      acetylhomoserine and glutamine, i.e. compounds (IIIa), (IIIb), (IIId)
      respectively. 3. The possibility that the bacterial synthetic reaction observed
      in the acid (II) metabolism with C. equi is analogous to peptide conjugation
      known in both animals and higher plants is discussed. A possible mechanism for
      this bacterial conjugation is also considered.

PMID- 1016255
TI  - Lack of effect of amino acid concentration on protein synthesis in the perfused
      rat liver.
AB  - The effect of increasing the perfusate concentration of amino acids on the
      incorporation of labelled valine into protein was followed in perfusions of rat
      livers lasting for 2h. A fixed amount of labelled and unlabelled valine was added
      to the perfusate as the other amino acids were increased in multiples of the
      concentrations normally found in rat plasma. Under these conditions no increase
      in valine incorporation was observed, which appeared to be in conflict with
      results published by other workers, However, a different method of labelling from
      that used here was used in the earlier studies. An increasing amount of a
      labelled amino acid was added as the concentrations of the unlabelled amino acids
      were increased in the perfusate. An experiment directly comparing to the two
      labelling methods produced results that indicated that the apparent increase in
      liver protein synthesis observed by the other workers could have been due to the
      method of radioisotope addition. It is therefore concluded that increasing the
      perfusate concentration of amino acids does not increase amino acid incorporation
      into liver protein.

PMID- 1016256
TI  - Carcass glycogen as a potential source of glucose during short-term starvation.
AB  - In small rats deprived of food for 19h (or 43h), 36% (or 39%) of the glycogen
      that disappeared was lost from the carcass and 64% (or 61%) from liver. Carcass
      glycogen is potentially a substantial source of glucose during short-term
      starvation via the Cori cycle.

PMID- 1016257
TI  - Effect of detergents on the N-and ring-hydroxylation of 2-acetamidofluorene by
      hamster liver microsomal preparations.
AB  - Effects of detergents such as cholate, deoxycholate and Triton X-100 were studied
      on N-and ring-hydroxylation of 2-acetamidofluorene by reconstituted and
      unresolved microsomal systems from livers of hamsters pretreated with 3
      methylcholanthrene. Triton X-100 (2.5 mg/nmol of cytochrome P-448) inhibited N
      and ring-hydroxylation by wholemicrosomal preparations by 40 and 90% respectively
      Deoxycholate at the same concentration inhibited both hydroxylations completely,
      whereas cholate inhibited N-and ring-hydroxylation by 40 and 50% respectively. In
      reconstitution studies, the presence of Triton X-100(0.5-1.0mg/nmol of cytochrome
      P-448) along with unsolubilized cytochrome P-448 fraction and solubilized
      reductase fraction increased N-hydroxylation to an appreciable extent compared
      with ring-hydroxylation. Both cholate and deoxycholate at 0.5-1.0 mg
      concentrations had a greater stimulatory effect on ring-than on N-hydroxylation
      activity in such a reconstituted system.

PMID- 1016258
TI  - Dialysis experiments on urinary immunoreactive human growth hormone by means of a
      collodion bag.

PMID- 1016259
TI  - The use of glucose-1-[32P]phosphate for the determination of hexose-1-phosphate
      uridyl transferase activity in red blood cells.

PMID- 1016260
TI  - Improved method for determining parathyroid hormone in biological material.

PMID- 1016261
TI  - Comparison of methods for the measurement of human protein synthesis.

PMID- 1016262
TI  - Liver phenylalanine hydroxylase assay.

PMID- 1016263
TI  - Response of well-fed adrenalectomized rats to tryptophan force-feeding on hepatic
      protein and RNA synthesis.

PMID- 1016264
TI  - [14C]oxalate synthesis from [U-14C]glyoxylate and [1-14C]glycollate in isolated
      rat hepatocytes.

PMID- 1016265
TI  - The isolation, properties, and assay of phenylalanine hydroxylase from human and
      rat liver.

PMID- 1016266
TI  - [Observations on the frequency of neoplasms and inflammatory processes of the
      oral cavity during the period from 1961 to 1970 (author's transl)].
AB  - The Authors carried out a clinical and statistical study of the frequency of
      malignant and benign neoplasms, inflammatory processes and pre-cancerous states
      in the mouth over the period from 1961 to 1970, comparing their findings with
      those provided by a previous investigation covering a similar period of time.
      Benign tumours appear to be more frequent than malignant ones, and the latter are
      found most frequently in males in their fifties. The most frequent site of
      malignant tumours is the lower lip, and histologically they are mainly found to
      be epithelial.

PMID- 1016267
TI  - [The physiotherapic aspect of omeral epicondilitis (author's transl)].
AB  - The Authors describe history, etiopatogenesis, clinic, therapy of omeral
      epicondilitis, very frequent affection. Physiotherapic aspects are studied by
      different methods. The indications are different compared to clinical aspect,
      pain modality, relapse eventuality. They conclude with personal considerations
      based on what observed in Orthopedic Clinica of Parma University.

PMID- 1016268
TI  - [Fulminant acute hepatitis treated by immunologic therapy (author's transl)].
AB  - Following the most recent results on immunological pathogenetic mechanism, on
      which seems to be based the malignant evolution of acute viral hepatitis the AA.
      have treated a patient affected of acute fulminant hepatitis by means of
      immunologic therapy with specific globulins anti-HBsAg. The result of this
      personal experience and the analysis of the data from the literature suggest the
      opportunity to use specific antibodies (HBsAb) associated with syntomatic and
      depurative therapies, with obvious limits of single experience.

PMID- 1016269
TI  - [The diagnostic accuracy of liver scanning by Tc99m s.c. (Confrontation with
      autoptic reports) (author's transl)].
AB  - The Authors for an exact valuation of the diagnosis of epatic diseases by Tc99m
      s.c. verified all autoptic reports of the Ospedali Riuniti in Parma during the 3
      last years. The Authors value diagnostic accuracy concerning the examinated cases
      of the epatic scanning.

PMID- 1016270
TI  - [Oral and i.v. iron therapy in haemodialysis patients (author's transl)].
AB  - Low serum iron level with a transferrin saturation below 16% is a crucial
      aetiologic factor of anaemia in haemodialysed patients. Current therapy usually
      is a correct dialytic and dietetic treatment and i.v. iron supply. Two groups of
      haemodialysis patients with low serum iron but a normal transferrin saturation,
      have been studied by comparing the efficacy of the i.v. and the oral iron supply.
      The serum iron of the two groups changed from low to normal level with highly
      significant difference. Haemoglobin and haematocrit did not change because of the
      normal transferrin saturation before the treatment. In conclusion, in uraemic
      patients treated by chronic dialysis, the oral and the i.v. iron therapy probably
      give the same result.

PMID- 1016271
TI  - [Effect of carbenoxolone (CBO) on metabolism of nucleic acids, polyamines and
      proteins of gastric mucosa "in vivo" and "in vitro" (author's transl)].
AB  - Carbenoxolone was administrated, by intubation per os, to guinea-pigs, then the
      animals were killed 2 and 4 hours later. In perfusion experiments, carbenoxolone
      was injected for 5,10 and 20 min respectively. The results show a decreased
      uptake of formiate-H3 into RNA and DNA in vivo. During perfusion of stomach, CBO
      causes a precocious enhancement of specific radioactivity of nucleic acids, then
      a decrease was observed. The pattern of polyamines in perfused stomach shows an
      increased uptake of putrescine-C14 into spermidine. Finally, the specific
      radioactivity of proteins was enhanced in vivo and in vitro by CBO. The results
      demonstrate that the drug  alterates the proliferative cell cycle and induces the
      synthesis of proteins.

PMID- 1016272
TI  - [Acid-base modifications induced by treatment with concentration-reinfusion of
      ascitis fluid in cyrrhosis (author's transl)].
AB  - In 9 cyrrhotic patients with ascites we have studied the acid base status and the
      renal acidogenic capacity (urinary titrable acidity, ammonia) before, during and
      after reinfusion of concentrated ascitic fluid. Acid-base parameters have been
      evaluated also in the ascitic fluid and in the concentrated reinfusion fluid. The
      treatment does not determine any significant variation of acid base equilibrium
      in the cyrrhotic patients, while there is a remarkable loosing of CO2 with
      lowering of pCO2 in the concentrated ascitic fluid. We discuss the main
      physiopathological factors involved in such a type of treatment.

PMID- 1016273
TI  - [Regulation of amino acid transport in avian fibroblasts from growing and
      quiescent cell cultures (author's transl)].
AB  - The regulation of amino acid transport across the cell membrane by adaptive
      mechanisms has been studied in chick embryo fibroblasts obtained from growing and
      quiescent cell cultures. Changes in transport activity as a function of time
      under various in vitro conditions (amino acid dependence, active and inhibited
      protein synthesis) have been evaluated by measurements of initial entry rates
      with representative amino acids.

PMID- 1016274
TI  - [Adriamycin induced chronic cardiotoxicity: a morphological ultrastructural study
      on ventricular myocardium and conducting system of rabbit heart (author's
      transl)].
AB  - The administration of high doses of adriamycin in rabbits causes morphologically
      evident alterations of cardiac myocites, such as cellular structure
      disorganization, myofilaments disappearance and vacuolar degeneration through the
      cytoplasm. The less damaged myocites show protein synthesis activation with newly
      produced myofilaments. Macrophages and fibroblasts are seen in the interstitium
      among markedly injured cells. As a response to the toxic damage induced by
      adriamycin, it would be seen an hypertrophic compensatory response in the well
      preserved cells and interstitial fibrosis. The conducting system shows similar
      but less extensive lesions as the ventricular myocardium.

PMID- 1016275
TI  - [Lesions of the femoral nerve during the gynaecological operations (author's
      transl)].
AB  - The Authors present two cases of unilateral and bilateral lesions of the femoral
      nerve and emphasize the frequency, the characteristics, the mechanisms and the
      course of such lesions.

PMID- 1016276
TI  - [Diagnostic problems posed by hypotrophic facio-scapulo-humeral syndromes
      (author's transl)].
AB  - The Authors, on the ground of the literature and of their own observations,
      stress the diagnostic non specificity of hypotrophic facio-scapulo-humeral
      syndromes: these sindromes, contrary to the current opinion, aren't always of
      primitive myodistrophic nature but may also be "neurogenic", inflammatory,
      collagenopathis, etc. In this connection they present an illustrative case of
      facio-scapulo-humeral syndrome which had clinical features typically "myogenic"
      but turned out to be "neurogenic" after electromyographic and histochemical
      investigation.

PMID- 1016277
TI  - [Long term follow-up after radical mastectomy for breast cancer (author's
      transl)].
AB  - 110 of 126 patients treated with Halsted mastectomy and postoperative loco
      regional radiotherapy, during period 1961-1969 have been controlled. Overall 5
      years survival resulted as following: Columbia Clinical Classification stage A
      90,6%, stage B 66,6%, stage C 28,5%, stage D 33,3%; 10 years survival in patients
      operated on in the period 1961-64 was: stage A 69,2%, stage B 53,3%, stage C 40%,
      stage D 0%. On the basis of the satisfing results obtained the authors conclude
      that it appears by now unjustified to modify this method in treating stage A and
      B breast cancer either utilizing less extended resections, or renoncing to the
      postoperative irradiation.

PMID- 1016278
TI  - [Effect of cardiopulmonary bypass on serum digoxin concentration (author's
      transl)].
AB  - The use of digitalis following cardiopulmonary bypass is studied by digitalemia's
      radioimmunoassay. The Authors does not find relation between digitalis and post
      operative arrhytmias. They think digitalis's tolerance is very good but suggest
      that further studies are necessary to state the correct use of the drug after
      open heart surgery.

PMID- 1016279
TI  - [The problem of spinal myoclonus (author's transl)].
AB  - A case of the so called "spinal myoclonus" in a 71 year-old-man affected by lung
      carcinoma is reported. Clinical manifestations and comparison with similar
      previously described in literature induce to believe in the existence of a
      myoclonic syndrome, whose pattern seems to give support to the attribute of
      "spinal", at least as conventional term. An involvement of intercalated neurons
      is advanced as pathogenic ground. Anyhow, possible suprasegmental implications
      are also considered.

PMID- 1016280
TI  - [On the mechanism of the formation of traumatic lesions of the larynx:
      observations on three cases (author's transl)].
AB  - The authors, having drawn attention to the rarity of traumatic lesions of the
      larynx, illustrate three cases mentioning in particular the disproportion between
      the external and internal lesions, (as has already been pointed out by other
      authors), and the mechanism of the formation of such lesions. This, in
      particular, on the strenght of interpretations of slight cutaneous lesions.

PMID- 1016281
TI  - [The Guyon's tunnel syndrome (author's transl)].
AB  - The Authors present two cases of compression of the ulnar nerve at the level of
      the Guyon's tunnel with a peculiar etiology. In fact, in the first patient the
      compression was caused by dilatation of veins accompaning the nerve and in the
      second case by the hypertrophic "piso hamata" ligament. The Authors also take the
      opportunity of making some pathogenetic and someiotic considerations this
      syndrome.

PMID- 1016282
TI  - [Post-traumatic syringomyelia (author's transl)].
AB  - We have examined a clinical case concerning a patient who, five years after a
      spinal cord injury, showed a series of symptoms due to the presence of a
      intramedullary cyst according to neurologists' general opinion. They think this
      cavitation is a development of acute myelomalacic cores or of a central
      haemorrhage. The extension of the cavities is regarded as a result of trasmission
      of venous pressure, brought about by coughing, straining and sneezing, to the
      spinal cord and of tethering of the cord at the side of trauma by dense
      arachnoidal adhesions, hence its adaptability to the extremes of movements is
      hampered.

PMID- 1016283
TI  - [Studies on the water quality of the river Po and its tributaries between Monte
      Cremona and Casalmaggiore. II. Period 1971-2].
AB  - The results relating to the research carried out on the river Po upstream and
      downstream Cremona town, at Casalmaggiore and at the mouths of the right side
      tributaries Arda-Ongina and Taro in the period 1971-72 are reported in the
      present note. The samplings took place once every month and on the same day flow
      measurements were effected by the Magistracy of the river Po in the five
      stations. The results of this first series of sampling have shown a good
      stability of the water quality of the river Po, in the different seasons and in
      the different hydrological conditions. No significative differences were poi nted
      out for the most part of the determined parameters between the stations upstream
      and downstream Cremona and Casalmaggiore, except the turbid load (turbidity,
      suspended matter at 105 degrees C, setteable solids) which presented at
      Casalmaggiore an average value absolutely higher than the calculated one which
      was achieved considering concentrations and river flow at Cremona and at the
      mouths of Arda-Ongina and Taro. With few exceptions the water quality keeps a
      good level for fish life and its actual pollution degree let us think it possible
      to improve the situation in a short time. Only microbiological parameters are
      excepted, as they exceed the proposed limits for recreation and bathing uses
      (W.Q.C.).

PMID- 1016284
TI  - [Duchenne muscular dystrophy in girls (author's transl)].
AB  - The AA., after a review cases of girls suffering from a muscular dystrophy like
      Duchenne, present two cases that they think to set in the same nosographical
      context. Even though they admit its extreme rarity and the possiblility that many
      cases previously published are controversial, they accept that Duchenne
      myodistrophic syndromes certainly occur in girls, even if their substantial
      nature remain uncertain.

PMID- 1016285
TI  - [Syringomyelia: four clinical cases are reported as opportunity to reexamine the
      pathogenetic hypotheses (author's transl)].
AB  - In this paper four clinical cases of syringomyelia are presented as an
      opportunity to reexamine more discussed pathogenetic hypotheses. The authors are
      referring in particular to Gardner's theory since he has the merit of explaining
      the anomalies often associated with syringomyelia. In Gardner's opinion
      syringomyelia might be due to the non-perforation of the rhombic roof.

PMID- 1016286
TI  - [Combined treatment for malignant primitive brain tumors in infants using CCNU,
      neurosurgery and radiotherapy (author's transl)].
AB  - The preliminary data (13 cases) is used to make a comparison between the survival
      length from the beginning of chemotherapy of these pediatric neuro-oncotypes with
      that of adults bearing sovra-tentorial astrocytomas or glioblastomas given the
      same treatment. Approximating, by means of normal distributions, the experimental
      results the Authors also note that the clinical efficacy of CCNU is more or less
      the same for infants and adults.

PMID- 1016287
TI  - [The chemiolysis of the hypophysis: a technical improvement (author's transl)].
AB  - The anesthesist is very often asked to manage severe painful syndromes in
      patients suffering widespread malignant tumours. So often, the extent of
      neoplastic diffusion is such that common technics for analgesic block cannot be
      performed. The chemiolysis of the hypophysis-according to Moricca-performed
      primarily for therapeutic purposes has also shown a powerful analgesic effect.

PMID- 1016288
TI  - Bronchial histamine reactivity: its relationship to the reactivity of the bronchi
      to allergens.
AB  - The aim of this study was to examine the proposal that the magnitude of the
      response of the bronchi to an immediate allergic reaction depends not only on the
      degree of sensitization of the bronchi by allergen specific IgE antibody but also
      on the reactivity of the bronchi to the vasoactive mediators which are released
      during immediate allergic reactions. This was done by determining the bronchial
      reactivity to Dermatophagoides pteronyssinus and to histamine of both symptomatic
      and asymptomatic groups of atopic subjects who had comparable serum levels of D.
      pteronyssinus specific IgE. Positive bronchial responses to the D. pteronyssinus
      extract were recorded with both the symptomatic and asymptomatic subjects, the
      mean bronchial threshold dose of allergen being significantly higher in the
      asymptomatic than in the asthmatic patients. There was a highly significant
      correlation between the serum level of allergen specific IgE and the bronchial
      threshold dose of allergen extract and also between the bronchial threshold dose
      of allergen extract and of histamine in all groups of subjects. The ability to
      predict bronchial reactivity to the allergen from the serum level of allergen
      specific IgE within each group was significantly better if the bronchial
      reactivity to histamine was included in the correlation analysis. This supports
      the hypothesis that whether a particular subject who is producing specific IgE
      antibody will develop symptoms on the inhalation of that allergen depends not
      only on the amount of allergen which he inhales and on the degree of
      sensitization of his bronchi but also on the reactivity of his bronchi to the
      vasoactive mediators which are released by allergen-IgE interaction.

PMID- 1016289
TI  - A new immunodiagnostic test in onchocerciasis.
AB  - The radioallergosorbent (RAST) technique was used as a diagnostic test for
      onchocerciasis. IgE antibodies for Dirofilaria immitis antigen were found in
      thirty-one of fifty-seven (54%) affected patients.

PMID- 1016290
TI  - Asthma due to inhaled chemical agents--fumes from 'Multicore' soldering flux and
      colophony resin.
AB  - Four patients with occupational asthma associated with exposure to soldering flux
      or hot-melt glue containing pine resin (colophony) were subjected to occupational
      type inhalation challenge testing. All four gave immediate bronchial reactions to
      inhalation of the fumes, varying from one breath to 3 min of exposure. The
      clinical history and provocation test reactions suggest hypersensitivity to
      colophony fumes.

PMID- 1016291
TI  - Allergenic potency of bee antigens measured by RAST inhibition.
AB  - The potency of various bee antigens including bee venom, several whole bee body
      extracts and fractions of bee venom was studied using the RAST inhibition method.
      As compared to whole bee body extract, bee venom was a much more potent inhibitor
      of both bee venom and whole body RAST, suggesting that venom has a greater
      capacity to bind specific bee IgE antibodies. Whole body extracts also varied
      substantially in their inhibiting activity. Phospholipase A and hyaluronidase
      were the most potent of the bee venom fractions suggesting their potential use as
      an assay for standardization of insect extracts.

PMID- 1016292
TI  - [International strategies in medical education: technical assistance and
      technical cooperation].
AB  - This article reviews the evolution of international activity for national
      development in general and for medical education in particular. The concepts of
      traditional technical aid and the new method of technical cooperation are
      studied. That method appeared just before the beginning of this decade as a
      response to needs existing at the time to coordinate development with the
      emerging international economic order. This article discusses the emphasis given
      to strategy in this new concept of international activity. Strategy, in this
      sense, consists of a clear definition of goals and objectives by the countries
      themselves, mobilization of local resources, and full participation of national
      personnel in all phases of the process. The projects promoted by the Pan American
      Health Organization in applying technical cooperation to the field of health
      manpower training are discussed. Such activities include: coordinating the above
      mentioned training, providing overall support for institutional development,
      training professors and administrators, developing educational technology,
      creating and developing a network of biomedical information, developing social
      sciences as applied to medicine, and encouraging medical, epidemiological,
      social, and operational research.

PMID- 1016293
TI  - [Teaching of physiology in veterinary medicine education in Latin America].

PMID- 1016294
TI  - [Considerations on graduate education of sanitary engineering in Latin America].
AB  - The author reviews the profound process of change in Latin America which presents
      serious problems for environmental engineering and, consequently, for education
      in the various disciplines that comprise this specialization. The explosive
      growth of knowledge and the increase responsibilities of professionals place
      extreme pressure on engineering schools. These schools are forced to consider
      curricular changes as well as changes in admission policies and in the image and
      the service which they should present to society. At the present time, 25
      engineering schools offer an "option" of sanitary engineering and 12 schools
      offer graduate courses for an M.A. in environmental engineering. In the schools
      themselves, a combination of fulltime and part-time professors prevails. Graduate
      teaching programs are expected to provide: a) increasingly complex, new
      scientific and technologic knowledge, b) duly selected disciplines; and c)
      balanced management techniques. Certain plans of action may be considered. Among
      these are increasing the number of schools that offer graduate courses, revising
      curricula, encouraging higher enrollment, including research as a standard
      element in teaching and, in general, seeking higher standards of excellent.
      Prospects for the future seem to indicate that the following actions should be
      taken: 1) increasing interdisciplinary programs; 2) making use of the potential
      offered by continuing education; and 3) encouraging the development of doctoral
      studies.

PMID- 1016295
TI  - [Problems of the postgraduate training of sanitary physicians in labor hygiene].

PMID- 1016296
TI  - [Physiological evaluation of different types of monotonous work].

PMID- 1016297
TI  - [Analysis of the development of the skill of handling an inertial object in an
      emotionally stressed situation].

PMID- 1016298
TI  - [Assessment of the opthalmological changes in persons subjected to the action of
      microwaves].

PMID- 1016299
TI  - [Method for studying the action of radio frequency electromagnetic waves on the
      human body under industrial conditions].

PMID- 1016300
TI  - [Reliability of the computational methods for determining the MAC value for
      harmful chemical substances in the air of a work area].

PMID- 1016301
TI  - [Features of teaching preventive sanitary inspection in industry].

PMID- 1016302
TI  - [Organization of laboratory control over working conditions in Kiev industrial
      enterprises].

PMID- 1016303
TI  - [Work hygiene problems and the state of health of workers in the manufacture of
      mixed feeds].

PMID- 1016304
TI  - [Changes in the enzymatic activity in the lung tissue of rats with experimental
      silicosis].

PMID- 1016305
TI  - [New data on the use of the hexenal test in a toxicological experiment].

PMID- 1016306
TI  - [Safety criteria for the penetration of industrial poisons into the body through
      the skin].

PMID- 1016307
TI  - [Effect of adenosine monophosphoric acid on oxidative phosphorylation in the
      liver under the prolonged action of microwaves].

PMID- 1016308
TI  - [Toxicological and hygienic study of the dust from a glass plastic based on a
      phenol-formaldehyde resin].

PMID- 1016309
TI  - [Determination of the erythrocyte count in rat blood with the aid of a
      photoelectrocolorimeter (FEK-M)].

PMID- 1016310
TI  - [Follow-up of a group of institutionalized aged].

PMID- 1016311
TI  - [The institutions for the aged in Israel].

PMID- 1016312
TI  - [Mediastinal tumors in infants and children].

PMID- 1016313
TI  - [Hemoglobin C in an Arab family].

PMID- 1016314
TI  - [Acute adrenal insufficiency].

PMID- 1016315
TI  - [Clinical experience with the Jamshidi liver biopsy needle and syringe].

PMID- 1016316
TI  - [Fibrosarcoma of the dura mater].

PMID- 1016317
TI  - [Human subcutaneous myiasis due to Dermatobia hominis].

PMID- 1016318
TI  - [War eye injuries, with special reference to foreign bodies. Part 2: blunt
      traumata].

PMID- 1016319
TI  - [Staphylococci in foods: recent achievements of food industries and public health
      authorities].

PMID- 1016320
TI  - [The sudden death syndrome in infancy].

PMID- 1016321
TI  - [Hemorrhoids].

PMID- 1016322
TI  - [Renal insufficiency accompanying hepatic insufficiency].

PMID- 1016323
TI  - [The overweight infant--a disadvantage].

PMID- 1016325
TI  - [Nobel Prize winners in medicine--1976].

PMID- 1016324
TI  - [Precordial pain and smoking].

PMID- 1016326
TI  - [Pulmonary fibrosis in childhood].

PMID- 1016327
TI  - Chromatolytic changes in Deiters' nucleus following spinal cord lesions in the
      rat.

PMID- 1016328
TI  - Reaction of the olivary and tectal neurons to hemisection or transection of the
      cervical cord (studied by a modification of Gudden's method).

PMID- 1016329
TI  - Morphological development of the choroid plexus in chick embryos.

PMID- 1016330
TI  - Relationships in the developing body wall and limb bud blastemas of the chick
      embryo.

PMID- 1016331
TI  - A note on an anomalous outgrowth of mesonephros in Heteropneustes fossilis
      (Bloch).

PMID- 1016332
TI  - Variability and development of the quadratus plantae muscle in man.

PMID- 1016333
TI  - Growth and position of the mandible during secondary palate closure in the mouse.

PMID- 1016334
TI  - Satellite cells in the limb musculature of the axolotl.

PMID- 1016335
TI  - Comparative morphology and histology of the alimentary canal of two Indian birds.

PMID- 1016337
TI  - Windsor C. Cutting Memorial Lecture. Clinical pharmacology: hard sell or soft?

PMID- 1016336
TI  - Basic morphometric parameters of development of the mouse placenta.

PMID- 1016338
TI  - Prevalence of rodent endemic typhus on the Island of Maui.

PMID- 1016339
TI  - IMP: a new method for health problem assessment.
AB  - This paper presents a new method for health problem assessment, called IMP. It is
      based upon the premise that the critical step in the development of policy
      decisions isthe definition of health problems at the community level. The method
      is an extension of the Delphi technique but has been significantly improved by
      the determination of the critical variables in the problem set and by the
      incroporation of a structured logic system and of professional judgment. The
      study compares the IMP method with data gathered by traditional, epidemiological
      prevalence surveys and also with data from a computer simulation. The conclusion
      is unavoidable: the IMP method is an accurate as the other methods, at far less
      cost. The problem of preventable bureaucratic blindness has been used as an
      illustration of the application of this technique.

PMID- 1016340
TI  - Evaluating drugs and determining the drug needs of developed and developing
      countries.
AB  - The practice of reviewing drug utilization provides a surveillance system for
      monitoring the efficiency of drug distribution and drug consumption; it also
      provides a data base for the interpretation of the frequency of adverse drug
      reactions and helps to identify gaps in the delivery of a crucial aspect of
      health services: the provision of safe and efficacious medicines. Malconsumption
      (either over- or under-utilization or needless prescribing) can be identified and
      economies might be achieved, once these problems are corrected. Linking drug
      utilization with standard health indices, such as morbidity and mortality rates,
      can help assess the effects of widely used drugs, both adverse and beneficial.
      Drug utilization review should be considered an essential activity of a well
      organized health delivery system; it has great potential for both health planning
      and evaluation. These positions are discussed as they relate to developed and
      developing countries.

PMID- 1016341
TI  - Health services research and health policy.
AB  - Health services research (HSR) has the potential to influence the decision-making
      process in a health services system that is acutelearchers feel, with some truth,
      that their research has had only a limited effect on health policy. Some reasons
      for this are described, including the primacy of political, rather than
      technical, considerations in policy making, the lack of a comprehensive health
      policy, and the poor quality and irrelevance of much HSR. The role of funding for
      HSR by the Federal government is described; it is shown that the Federal effort
      is fragmented, despite the consolidation efforts made in 1968. Increased support
      for specific targeted, problem-solving health services research is proposed, and
      some possible methods to achieve this are described.

PMID- 1016342
TI  - A proposal for a primary care registry.
AB  - A regional, voluntary, registry mechanism is proposed through which any citizen
      could indicate his intention of seeking primary health care from a physician,
      clinic, or institution that has also registered. By mutual agreement, the
      provider would recognize the registrant as a regular primary care patient.
      Providers would regularly receive lists of their registered primary care
      patients, including descriptive statistical summaries where appropriate. Such a
      registry would aid health care planners to promote a more equitable and efficient
      delivery system for primary care services.

PMID- 1016343
TI  - Building a comprehensive geriatric health care system: a case study.
AB  - This case study focuses on the efforts of three urban medical care institutions-
      a Health Maintenance Organization, a nursing home, and a university hospital--to
      form an interorganizational relationship. The purpose of the relationship was to
      utilize the services of the three organizations in order to respond to the
      comprehensive health needs of an urban geriatric population. Movements in this
      triadic organizational relationship are described and analyzed in terms of four
      conceptual stages--exploration, negotiation, interaction and performance, and
      termination. Problems arising during these stages were not resolved and the
      relationship was terminated after approximately two years of existence. A
      sociological discussion of the case focuses on why the relationship failed. The
      organizational relationship was disrupted by three stresses that occurred during
      the four stages of the relationship. Stresses emerged for each organization in
      the areas of organizational integration, professional coordination, and
      environmental adaptation, making it difficult for the three to become integrated
      into an organizational system. As a result, the HMO, the nursing home, and the
      hospital did not benefit from relationships that could have enabled them to
      develop the multi-organizational system necessary to sustain an innovative,
      comprehansive geriatric health project. If, as Whitehead said, the greatest
      invention of the nineteenth century was the invention of the method of invention,
      the task of the succedding century has been to organize inventiveness. The
      difference is not in the nature of invention or of inventors, but in the manner
      in which the context of social institutions is organized for their support.

PMID- 1016344
TI  - As long as you're up, pick me a name.

PMID- 1016345
TI  - Medical care as a commodity: an exploration of the shipping behavior of patients.
AB  - A 10% household sample of high- and low-income census tracts was interviewed to
      assess the extent of doctor shopping. In 632 households studied, 53% of high
      socioeconomic status and 51% of low socioeconomic status families had shopped for
      or changed doctors of their own volition. During the previous year, 4% of each
      socioeconomic group had consulted more than one doctor without referral for the
      same episode of illness. Shoppers could be distinguished from non-shoppers-
      shoppers were younger, were better informed about medical specialties, were less
      self-reliant, more hypochondriacal, expressed less hostility towarn physicians,
      and had less positive attitudes toward the medical care system. The differences
      between shoppers and non-shoppers were generally similar for both high and low
      socioeconomic status groups. In addition, 52% of the families studied had been
      forced to change doctors because of circumstances beyond their control, i.e., the
      patient moved or the doctor moved, retired, or died.

PMID- 1016346
TI  - Preventive and episodic health care of inner-city children.
AB  - Children in low-income, inner-city households who used different sources of
      ambulatory care were analyzed with regard to their experiences in securing
      preventive and episodic illness care. This analysis is derived from a larger
      study that investigated the utilization of health care systems by groups within
      an inner-city community; it focused on the Outpatient Department of a large
      teaching hospital and on the impact of a new Health Maintenance Organization
      (HMO). Data were obtained through household interviews of three sample
      populations: enrollees in an HMO, residents of a public housing project, and
      persons from the general community. When preventive health care was examined, our
      findings showed that, while the majority of children of school age were
      immunized, only about half of the children under age 6 were. Among children aged
      3 through 5, those attending day care centers were more likely to be immunized
      than those not in such programs. There were indications that children using the
      HMO were more frequently receiving preventive services, particularly general
      physical examinations. There was no relationship between the usual source of
      care, or day care participation, and whether a child received care for an episode
      of illness. There were differences by age and usual source of care in seeking
      care for earaches and in receiving regular care for asthma. The patterns of
      health care utilization found in this study promote interest in the influence of
      the source of ambulatory care for children in other socioeconomic groups.

PMID- 1016347
TI  - Sodium metabolism in hypertension: Part I. Sodium content in cardiovascular
      tissue in spontaneously hypertensive rat.

PMID- 1016348
TI  - Sodium metabolism in hypertension: Part II. Effects of salt loading on urinary
      excretion of sodium in spontaneously hypertensive rat.

PMID- 1016349
TI  - Sodium metabolism in hypertension: Part III. Effects of hypertensive and
      antihypertensive agents on sodium metabolism in perfused hearts.

PMID- 1016350
TI  - [Condition of the stomach in chronic and acute diseases of the gallbladder and
      liver].

PMID- 1016351
TI  - [Bile acid content in blood serum of patients with chronic inflammatory diseases
      of the liver and biliary tract].

PMID- 1016352
TI  - [Use of neomycin in the treatment of acute hepatoportal encephalopathy].

PMID- 1016353
TI  - [Relation between central hemodynamics and hepatic blood flow].

PMID- 1016354
TI  - [Functional condition of the pancreas in aging].

PMID- 1016355
TI  - [Acute disorder of renal function in pancreatitis].

PMID- 1016356
TI  - [Bactericidal properties of blood serum in patients with typhoid].

PMID- 1016357
TI  - [Paraamyloidosis of the heart in myeloma].

PMID- 1016358
TI  - [Thromboembolic syndrome in pulmonary carcinoma].

PMID- 1016359
TI  - [Acute renal insufficiency in thrombosis of renal arteries].

PMID- 1016360
TI  - [Acute steroid-induced stomach ulcer complicated by profuse hemorrhage in a
      patient with serum hepatitis].

PMID- 1016361
TI  - [Case of situs inversus].

PMID- 1016362
TI  - [Perspectives in the treatment of peptic ulcer].

PMID- 1016363
TI  - [Prostaglandin content in blood plasma in various endocrine diseases].

PMID- 1016364
TI  - [Myocardial infarct in young persons].

PMID- 1016365
TI  - [Pathogenesis, immunity and specific  prophylaxis of bacterial carrier state in
      salmonellosis].

PMID- 1016366
TI  - [Meaning of various factors in changes of physical load tolerance in patients
      with chronic ischemic heart disease].

PMID- 1016367
TI  - [Use of steroid and nonsteroid anabolites in ischemic heart disease].

PMID- 1016368
TI  - [Evaluation of functional condition of the myocardium in patients with
      cholecystitis].

PMID- 1016369
TI  - [Glucose tolerance test and excretion of insulin in coronarogenic diseases].

PMID- 1016370
TI  - [Complications in the treatment of paroxysmal arrhythmias with novocaine amide].

PMID- 1016371
TI  - [Role of genotype in the development of ischemic stroke].

PMID- 1016372
TI  - [Clinical peculiarities of vasomotor cephalgia].

PMID- 1016373
TI  - [Hypertension and anomalous kidneys].

PMID- 1016374
TI  - [Condition of kidneys in protective inhibition coma in patients with cerebral
      stroke].

PMID- 1016375
TI  - [Speed of pulse wave in thromboobliterating diseases of the arteries in the
      extremities].

PMID- 1016376
TI  - [Adrenal cortex hormones in surgical treatment of patients with embolism of major
      arteries in the extremities].

PMID- 1016377
TI  - [Blood coagulation and resistance of capillaries in patients with rheumatic heart
      disease].

PMID- 1016378
TI  - [Current questions on the pathogenicity of lamblia].

PMID- 1016379
TI  - [Errors and difficulties in diagnosis of diverse purulent peritonitis].

PMID- 1016380
TI  - [Role of calcium in secretion of hydrochloric acid].

PMID- 1016381
TI  - [Damage to inner organs in chronic alcohol abuse].

PMID- 1016382
TI  - [Paraneoplastic syndromes in internal medicine].

PMID- 1016383
TI  - [Stridor congenitus in macroglossia and dysplasia of tracheal cartilage].

PMID- 1016384
TI  - [Pneumatic dilatation of esophageal achalasia].

PMID- 1016385
TI  - [Endoskopie am operierten Magen mit dem panendoskop F7].

PMID- 1016386
TI  - [Hemodynamics of the pulmonary circulation during a multistep exercise test in
      healthy subjects].

PMID- 1016387
TI  - [Therapy of drug dependence in adolescents. Clinical aspects of somatic
      detoxification].

PMID- 1016388
TI  - [Sodium carbenoxolone. A review].

PMID- 1016389
TI  - [Pelvis examination model " Gynny" for instruction of students].

PMID- 1016390
TI  - [Local treatment of chronic arthritis].

PMID- 1016391
TI  - [Contribution to the problem of Arthrogryposis multiplex (author's transl)].
AB  - A case of Arthrogryposis multiplex appearing after birth and of no
      characteristical course is described. It is shown that in respect to existing
      works for diagnosis of Arthrogryposis multiplex the insufficiency of the hitherto
      existing valid diagnostic criterions is obvious. This especially because the
      pathogenesis of Arthrogryposis multiplex is unknown. Trying to look for the
      condition of the connective tissue of our patient, it was found that the collagen
      of skin shows a young matter of polymerisation and a nearly correlating electron
      microscopical picture.

PMID- 1016392
TI  - [Treatment of arthritic psoriasis with Demoplas Clinical and scintigraphic study
      in 10 patients (author's transl)].
AB  - Clinical, X-ray, and scintigraphic (6mCi 99mtechnetium pertechnetate, 4mCi
      99mtechnetium pyrophosphate) tests for joint involvement were conducted on 11
      inpatients with psoriasis (4 female, 7 male), 6 of them cases of what is
      conventionally termed psoriatic arthropathy. These tests were performed both
      before and after a 12-day period of therapy with daily 4 x 1 coated tablets of
      Demoplas containing 150 mg phenylbutazone Scintigraphic tests showed that
      pathological radionuclide concentrations were present in at least one joint or
      group of joints in 10 out of 11 patients. Following therapy the previously
      pathological scintigraphic findings had stabilized completely in 4 patients and
      partially in 3 patients, but had not stabilized in 3 patients. The results of
      therapy with Demoplas as demonstrated by joint scintigraphy were thus good to
      satisfactory in 7 patients and unsatisfactory in 3 patients- possibly owing to
      the short duration of therapy. The improvement in scintigraphic results testifies
      to the therapeutic action of phenylbutazone on arthritic psoriasis. This can also
      be regarded as additional proof that psoriatic joint involvement is of an
      inflammatory and proliferative nature.

PMID- 1016394
TI  - The Salisbury Crags murder: H.M. Advocate v Ernst Dumoulin.

PMID- 1016393
TI  - Lassa fever.

PMID- 1016395
TI  - Identification of suspects in criminal cases.

PMID- 1016396
TI  - Ammonia absorption from the rumen to the systemic circulation with urea poisoning
      in goats.
AB  - To confirm the transfer of ammonia leaking from the rumen content via the liver
      to the perid by laparotomy. When ammonia leakage from the hepatic vein occurred,
      it was followed by an increase in ammonia concentration in the jugular vein.
      There were increases of ammonia concentration in the intestinal vein and in the
      thoracic duct after urea drenching. These increases suggested neither trapping
      ammonia in the peritoneal fluid nor responsibility for increases of ammonia in
      the systemic circulation, respectively. At times when respiration ceased due to
      urea poisoning, the peritoneal fluids wee in the fluid. The hypothesis of the
      peritoneal cavity-thoracic duct route of ammonia absorption, presented by some of
      previous workers on urea toxicity, was not supported in the present study.

PMID- 1016397
TI  - [Intensive counseling of parents in pediatric psychiatry].

PMID- 1016398
TI  - [Hallucinatory phenomenona during the withdrawal of stimuli].

PMID- 1016399
TI  - [Diagnosis and treatment of acute alcoholic intoxication].

PMID- 1016400
TI  - [Mania--very rarely diagnosed?].

PMID- 1016401
TI  - [Educational service in psychiatry. "Special" school for adults].

PMID- 1016402
TI  - [Myasthenia gravis and surgical mortality in thymectomy. Comment on the review by
      Lechner, Ott and Aranibar: "Immunosuppressive therapy of myasthenia gravis" (this
      J. 47, 353-356 (1976)].

PMID- 1016403
TI  - [Discussion contribution to the article by R. Haupt and H. Isermann "Learning and
      concentration ability of elderly patients with depressive syndrome and disorders
      of cerebrovascular circulation" (this J. 47, 269-271/1976)].

PMID- 1016404
TI  - [Psychotherapeutic defect or defective psychotherapy? Reply to the article:
      "Psychotherapeutic defect" by F. Reimer (this J. 46, 214/1975)].

PMID- 1016405
TI  - [Reply to the discussion comment by H. Ludeke: Psychotherapeutic defect of
      defective psychotherapy? (this J. 47, 742/1976)].

PMID- 1016406
TI  - [Concluding views of F. Reimer on the discussion comments of Mr. Hole and Messrs
      Rosin and Wessel to his lecture "The psychotherapeutic defect" (this J. 46,
      214/1975)].

PMID- 1016407
TI  - [Transfer factor].

PMID- 1016408
TI  - [Remarks on rupture of the heart in recent myocardial infarct].

PMID- 1016409
TI  - [Traumatic rupture of a pathological spleen in a case of sea-blue histiocyte
      syndrome].

PMID- 1016410
TI  - [Proliferating trichilemmal cysts (review of the literature and report of 2
      cases)].

PMID- 1016411
TI  - [Spongioblastoma of the cerebral hemispheres (histological and in vitro study)].

PMID- 1016412
TI  - [Inverted papilloma of the bladder (histogenetic hypothesis and report of a
      case)].

PMID- 1016413
TI  - [Peutz-Jeghers disease: considerations on a case followed for 19 years].

PMID- 1016414
TI  - [Case reports of cardiac and vascular dysplasia].

PMID- 1016415
TI  - [A case of coarctation of the middle-thoracic descending aorta].

PMID- 1016416
TI  - [Present status of pharmacoradiology of the gastrointestinal tract (author's
      transl)].
AB  - Based upon the findings in over 1200 patients, technique, indication and validity
      of pharmacoradiology in examinations of esophagus, stomach, duodenum, small and
      large intestine are critically evaluated and summarized. Dosis, effects, side
      effects and contraindications of the mostly applied pharmaca (Buscopan, Pro
      Banthine, Paspertin, Glucagon, Cholecystokinin and Caerulein) are listed. The
      value of pharmacoradiology of the gastrointestinal tract for clinical
      roentgenology is stressed.

PMID- 1016417
TI  - [Visceral and peripheral pharmacoangiography with angiotensin and bradykinin
      (author's transl)].
AB  - In a prospective study of 156 patients a total of 110 pharmacoangiographic
      examinations using Angiotensin and 46 investigations with Bradykinin were
      performed. In 21 cases both pharmaca were applied. In 111 patients with
      pathologic findings (tumors, cysts and inflammatory lesions) diagnostic
      information compared with conventional angiography, was improved in 80, equal in
      26 and reduced in 5 cases. In 21 studied patients using Angiotensin and
      Bradykinin, the overall diagnostic information was improved. Angiotensin is a
      suitable pharmacon in demonstration of malignant lesions. Bradykinin improves the
      demonstration of vessels affected by local inflammation and allows better
      visualization of the veins. The application of both pharmaca may help in certain
      cases to differentiate between inflammatory and malignant lesions.

PMID- 1016418
TI  - [Visualisation of gastric wall lesions in malignant tumors (author's transl)].
AB  - A simple and harmless method to determine the thickness of the stomach wall is
      described. The examination consists of a pneumoperitoneum with CO2 and a barium
      meal. The principle is the absorption of x-rays in three different media: gas,
      stomcah wall and barium. The method allows determination of the tumor-size and
      may avoid unnecessary surgery. All cases were verified by operation or autopsy.

PMID- 1016419
TI  - [Continuous electrocardiographic registering with magnetic ribbon: Holter's
      method].

PMID- 1016420
TI  - [Growth disorders in congenital heart diseases].

PMID- 1016421
TI  - [Temporary endocavitary pacemaker in acute myocardial infarct].

PMID- 1016422
TI  - [Vectorcardiographic analysis of ventricular repolarisation in acute myocardial
      infarct].

PMID- 1016423
TI  - [Electrolytic changes in patients operated on under extracorporeal circulation
      and total hemodialution].

PMID- 1016424
TI  - [Catheterisation in the newborn (evaluation of our experiences in 154
      catheterized cases)].

PMID- 1016425
TI  - [Epidemiology of congenital heart diseases in the island of Tenerife].

PMID- 1016426
TI  - [Management of valvular dysfunction. Our experience with the Bjork-Shirley disk
      prosthesis].

PMID- 1016427
TI  - [The myocardial factor in mitral valve stenosis; its evaluation by means of
      segmentary study of left ventricle contraction].

PMID- 1016428
TI  - [Supravalvular aortic stenosis. Report of 8 cases].

PMID- 1016429
TI  - [Systolic murmur with artificial cardiac pacemaker].

PMID- 1016430
TI  - [Lutembacher's syndrome: report of a case surgically corrected].

PMID- 1016431
TI  - [Surgical correction of transposition of the great arteries with interventricular
      communication and obstruction of the outlet of the left ventricle (Rastellis'
      operation)].

PMID- 1016432
TI  - [Frequency of hematological diseases in Mexico (author's transl)].

PMID- 1016433
TI  - [Chromosome studies in azoospermic patients (author's transl)].

PMID- 1016434
TI  - [Some aspects of myocardial metabolism of coronary patients studied in Mexico
      city (author's transl)].

PMID- 1016435
TI  - [Alveolar arterial oxygen gradient in normal adults living at 2240 m. above sea
      level (author's transl)].

PMID- 1016436
TI  - [Classification, diagnostic criteria and some therapeutic considerations of the
      solitary thyroid nodulf (author's transl)].

PMID- 1016437
TI  - [Mietens-Weber syndrome. A case report (author's transl)].

PMID- 1016438
TI  - [Pseudolymphoma of the small bowel. A case report (author's transl)].

PMID- 1016439
TI  - [A contribution of new cytogenetic techniques to the knowledge of chromosomal
      abnormalities (author's transl)].

PMID- 1016440
TI  - [Renal disease and pregnancy].

PMID- 1016441
TI  - [General principles of corticosteroid therapy (a reevaluation)].

PMID- 1016442
TI  - [Scintillographic examination of the straight chest syndrome].

PMID- 1016443
TI  - [Improved turbidity technic for the determination of lysozyme activity].

PMID- 1016444
TI  - [Hemodynamic course in the early postoperative period after myocardial
      revascularization surgery].

PMID- 1016445
TI  - [Carbohydrate metabolism in the postoperative period. Experimental study].

PMID- 1016446
TI  - [Gastric intramural infiltration by antral carcinoma].

PMID- 1016447
TI  - [Training of residents in mental health pediatrics].

PMID- 1016448
TI  - [A standard workplace card for the chemical industry- an important work tool for
      occupational medical care and research].

PMID- 1016449
TI  - [Results of airborne dust measurements in an industrial broiler farm].

PMID- 1016450
TI  - [The influence of various performance requirements on time estimation, visual
      discrimination reaction time, degree of alertness, spontaneous EEG activity and
      heart rate].

PMID- 1016451
TI  - [The development of self-adhesive low-ohm gel electrodes for the determination of
      bioelectric parameters].

PMID- 1016452
TI  - [Effects of combined administration of carbon monoxide and ethanol on motor
      neural conduction velocity in rats].

PMID- 1016453
TI  - [The effect of environmental noise on man at work and at home].

PMID- 1016454
TI  - [Workers' sensitivity to noise in relation to age].

PMID- 1016455
TI  - [The use of deaf workers for noisy jobs from the point of view of occupational
      medicine].

PMID- 1016456
TI  - [Stress on the vocal cords caused by phonation during noise exposure].

PMID- 1016457
TI  - [X-ray mass screening for neighborhood fluorosis].

PMID- 1016458
TI  - [Smell- and taste disturbances in chromium dye workers].

PMID- 1016459
TI  - [Current questions of air hygiene research].

PMID- 1016460
TI  - [Air hygiene studies in the district of Halle- immission measurements in the
      urban areas of Halle and Halle-Neustadt].

PMID- 1016461
TI  - [City council consultations- an effective method of taking responsibility for
      maintaining clean air].

PMID- 1016462
TI  - [Community hygiene monitoring in the city of Bautzen- a program for measuring
      aerosol-bound lead concentration in atmospheric air].

PMID- 1016463
TI  - [The distribution of epixylous lichens in the district town of Parchim
      (Mecklenburg)].

PMID- 1016464
TI  - [Experimental studies of the increased concentration of organic substances in
      shore-filtered ground water (waterworks of Halle-Beesen)].

PMID- 1016466
TI  - [Household pests and their significance for health].

PMID- 1016465
TI  - [The effect of an anion-active synthetic detergent base (dodecyl-benzene-sodium
      sulfonate) on some bacteria which are important for the self-cleaning of surface
      waters].

PMID- 1016467
TI  - [The effect and evaluation of boron compounds used in cockroach control].

PMID- 1016468
TI  - [Occurrence and control of cockroaches in bakeries].

PMID- 1016469
TI  - ["Typus melancholicus" from a psychometric viewpoint (part 1)].

PMID- 1016470
TI  - [Definition and measurement of the results of therapy].

PMID- 1016471
TI  - [Personality development of tie structure. Theoretical assessment of the
      practical relevance of the diagnosis "frustrated adolescent"].

PMID- 1016472
TI  - [Body image in hysterical psychoses].

PMID- 1016473
TI  - [Psychotherapy, pharmacotherapy and sports therapy for emotionally disturbed
      adolescents. Comparative analysis of ward and ambulatory therapy using
      physiological and psychological methods].

PMID- 1016474
TI  - [Close contact with the "unconscious". Apallic syndrome as an experience].

PMID- 1016475
TI  - Electron microscopy of stages of Isospora felis of the cat in the mesenteric
      lymph node of the mouse.
AB  - Stages of Isospora felis of the cat in the mesenteric lymph node of the mouse 25
      days after oral inoculation with oocysts, have been described at the
      ultrastructural level. The organisms occurred singly within parasitophorous
      vacuoles in host cell cytoplasm and were sporozoite-like, having a large
      crystalloid body up to 5.5 mum in length posterior to the nucleus. The size and
      appearance of the parasitophorous vacuole varied. Some vacuoles contained
      numerous, small, electron dense granules about 30 nm in diameter. Because of the
      aggregation of granules and their arrangement within the parasitophorous vacuole,
      the impression was sometimes gained by light microscopy that parasites were
      surrounded by a sheath or cyst wall. However, a cyst wall was not present. In
      host cells, spherical, membrane-bound bodies with a homogeneous, electron dense
      core and a maximum diameter of 0.25 mum were filed along the limiting membrane of
      the parasitophorous vacuole. These extra-intestinal parasites were considered to
      be waiting stages, with a biological function similar to that of the tissue cyst
      stage of other general of isosporan coccidia.

PMID- 1016476
TI  - [Scanning electron microscope studies of Echinococcus multilocularis cysts
      (author's transl)].
AB  - In the present paper, morphologic studies on experimental echinococcosis are
      reported. Following i.p. infection of gerbils (Meriones unguiculatus) with
      Echinococcus multilocularis scolices, the development of cysts within the
      internal organs of the experimental animals could be readily visualized by
      scanning electron microscopy.

PMID- 1016477
TI  - The development of brood capsules and protoscolices in secondary hydatid cysts of
      Echinococcus granulosus. A histological study.
AB  - Using the Mongolian jird (Meriones unguiculatus) as a laboratory host for the
      cystic stage of the British horse strain of Echinococcus granulosus, the mode of
      development of brood capsules and protoscolices was studied histologically. The
      successive stages in development in secondary hydatid cysts are described and
      shown to correspond closely with previous observations on primary hydatid cysts.
      The usefulness of this experimental model for future ultrastructural studies is
      emphasized.

PMID- 1016478
TI  - Stereoscan studies of eggs, free-swimming and penetrating miracidia and early
      sporocysts of Fasciola hepatica.
AB  - The egg of Fasciola hepatica has a smooth surface with a slightly elevated circle
      marking the fracture of the operculum. The operculum and the aperture have
      crenated edges. The epithelial cells of the miracidium are covered with long
      cilia. When miracidia are vibrated in an ultrasonic cleaner the cilia of the
      epithelial cells of the four posteroir tiers are broken off only leaving
      longitudinal rows of cilium stubs, whereas the cilia of the first tier are still
      retained. The apical papilla is provided with a dorso-ventral furrow,
      multiciliated pits and isolated sensory cilia. The narrow intercellular ridge is
      smooth, whereas the epithelial cells have small cytoplasmic knobs between the
      cilia. The penetration into the snail (Lymnaea truncatula) and the transforamtion
      into sporocyst may be separated into three phases. (1) Less than 1 min after
      attachment to the snail the ciliated cells of the anterior tier are shed and swim
      away. (2) The cilia of the remaining cells beat violently and after about 5 min
      most cilia are broken off near the cell surface. The miracidium remains for about
      15 min embedded as far as the intracellular ridge receptors (lateral papillae and
      sheathed ciliated nerve endings). During this period extensive contraction and
      relaxation of the body are performed. (3) The final penetration of the snail
      epithelium takes about 15 min. Simultaneously with the penetration into the snail
      tissue the "bald" cells (epithelial cells with cilium stubs only) of the four
      posterior tiers loosen, florm globules and fall off. The surface below the cells
      is smooth and in cytoplasmic continuity with the intercellular ridge and the
      apical papilla, and this syncytium forms the later tegument of the sporocyst.
      After a few days the tegument of the sporocyst is provided with microvillus-like
      projections and the apical papilla and sensory structures are lost.

PMID- 1016479
TI  - [Comparative study of the biological properties of strains of M. hominis].

PMID- 1016480
TI  - [Spatial conformation of cold antibodies].

PMID- 1016481
TI  - [Effect of damage to structures of the anterior and posterior hypothalamus on the
      uptake and digestion of labeled antigen by macrophages].

PMID- 1016482
TI  - [Dynamics of changes in the concentration of nucleic acids in the ovaries and
      endometrium of rats with experimental polycystosis].

PMID- 1016483
TI  - [Combined effect of vitamin E and peroxidates of unesterified fatty acids on
      urokinase and histidase activity].

PMID- 1016484
TI  - [Reactions of the hypothalamo-adrenal-ovarian complex of rats during use of local
      hypothermia].

PMID- 1016485
TI  - [Disorders of cholinergic mediation under hyperthermic conditions and their
      experimental pharmacotherapy].

PMID- 1016486
TI  - [Dynamics of changes in the concentration of copper and zinc in the bodies of
      rats with parasitemia].

PMID- 1016487
TI  - [Role of noradrenaline in regulating the vascular thermoregulatory response of
      the body].

PMID- 1016488
TI  - [Characteristics of cerebrovascular diseases according to findings of neurologic
      hospitals].

PMID- 1016489
TI  - [Use of actographic studies in intensive care units].

PMID- 1016490
TI  - [Anatomy and topography of the trunk of the accessory nerve].

PMID- 1016491
TI  - [Blood enzyme spectrum in cancer and precancerous diseases of the stomach].

PMID- 1016492
TI  - [Effect of underwater spinal traction on the functional state of the
      cardiovascular system of patients with lumbosacral radiculitis].

PMID- 1016493
TI  - [Use of different compositions of cyanacrylate glue for experimental suture-less
      united of lung wounds].

PMID- 1016494
TI  - [Electromyographic study of ureteral motor function in the presence of stones in
      the renal pelvis and different parts of the ureter].

PMID- 1016495
TI  - [Dermatoglyphic studies of the hands of relatives of children with congenital
      defects in brain development].

PMID- 1016496
TI  - [Treatment of migraine patients with the new anti-serotonin preparation Dezeril
      retard].

PMID- 1016497
TI  - [Differential diagnosis of neurocirculatory dystonia of the hypertensive type
      from stage I hypertension].

PMID- 1016498
TI  - Hydro- and hemodynamic effects of catheterization of vessels. II. Model
      experiments comparing circular and annular lumen area reduction.
AB  - Experiments and a simple theoretical analysis have been performed concerning the
      flow through circular (stenosis) and annular (catheter piece) lumen area
      reduction of rigid- and elastic-walled vessels. Both steady and pulsatile flow at
      various volumetric flow rates were investigated. A good agreement between the
      experimental and the analytical results has been found. A critical annular lumen
      area reduction exists on a par with the well-known critical stenosis. The
      strongest reduction in pressure and in volumetric flow rate was caused by the
      catheter pieces, compared with the stenoses. The per cent reduction in pulse mean
      pressure and in volumetric mean velocity at pulsatile flow was equal to the per
      cent reduction in pressure and volumetric mean velocity at steady flow. The
      influence of the geometrical shape of the stenoses and the catheter pieces is
      further discussed.

PMID- 1016499
TI  - Catheter angiography and venous thrombosis.

PMID- 1016500
TI  - Estimation of coronary artery stenosis. Limitations of present methods.

PMID- 1016501
TI  - Technique of coronary angiography.
AB  - A new manufacturing process and new shapes of the left and right catheters for
      coronary angiography by the transfemoral route increase the safety of the
      examination by reducing the time and avoiding the risks involved in catheter
      occlusion of the arteries. The simultaneous filling of the sinus and the whole
      coronary artery from its origin increases the anatomic information. Pressure
      monitoring is unnecessary.

PMID- 1016502
TI  - Growth rate of renal carcinoma as demonstrated by repeat angiography.
AB  - Thirteen patients with renal carcinoma, primarily not operated upon, were re
      evaluated 1 to 71 months after the first nephroangiography. Tumour progression
      could be demonstrated in 7 cases with a maximum linear diametric growth rate of
      0.5 cm/2.5 months. The reasons for absence of growth in the remainder are not
      apparent, but probably related to the state of immunologic defense mechanism of
      the host.

PMID- 1016503
TI  - Nephroangiography in amyloidosis.

PMID- 1016504
TI  - Epinephrine in the angiographic evaluation of experimental kidney trauma.
AB  - Selective nephroangiography was performed in the dog following percutaneous
      needle biopsy to evaluate epinephrine response. Traumatized vessels respond
      normally to epinephrine, often with increased extravasation as the vessel
      recovers from epinephrine. A selective inability of the traumatized vessel to
      constrict was not noted.

PMID- 1016505
TI  - Complications of percutaneous transthoracic needle aspiration biopsy.
AB  - After 5,300 percutaneous transthoracic needle aspiration biopsy procedures in
      2,726 patients pneumothorax occurred in 27.2 per cent of the patients. Only 7.7
      per cent required exsufflation or drainage. The factors influencing the relative
      frequency and the severity of pneumothorax are discussed. Bleeding around the
      punctured lesions was found in 11 per cent, and hemoptysis in 2 per cent but were
      of no clinical importance. In one case evidence of needle track implantation was
      found. The theoretical and practical importance of tumour cell spread and spread
      of infection through the needle track is discussed. No air embolism or mortality
      occurred.

PMID- 1016506
TI  - Pneumocystography of benign and malignant intracystic growths of the female
      breast.
AB  - Pneumocystography established the preoperative diagnosis of 20 intracystic breast
      tumours including 9 benign intracystic papillomas and 11 cases of intracystic
      carcinoma generally considered to be a rarity. The method is described and
      details about the clinical and radiologic appearances of both benign and
      malignant intracystic tumours are given. The importance and advantages of the
      method are emphasized.

PMID- 1016507
TI  - Bone growth in the rabbit after irradiation.
AB  - The effect on bone growth of two locally given, different, unfractionated
      radiation doses (0.1 and 24 Gy) was tested in a rabbit litter aged 57 days. The
      effects on growth were registered with roentgen stereophotogrammetric length
      measurements for 75 days after irradiation. Growth of the right irradiated tibia
      was compared with the growth of the left non-irradiated tibia. After 7 to 9 days,
      24 Gy had caused a linear fall in growth to about 15 per cent. After a period of
      complete cessation, a slight growth was registered. 0.1 Gy had no significant
      growth retarding effect.

PMID- 1016508
TI  - Radiologic aspects of BCG-osteomyelitis in infants and children.
AB  - An account is given of results of the radiologic examination of 29 infants and
      children with bone tuberculosis caused by the Bacilli Calmette-Guerin (BCG) as a
      complication to intradermal vaccination. The diagnosis is based on radiologic
      appearances, microscopy and bacteriologic examination of specimens obtained from
      the bone lesions. The radiologic appearance of the bone lesions is in most cases
      characteristic and differs decisively from that of pyogenic osteomyelitis and
      malignant disease.

PMID- 1016509
TI  - Pelvimetry in breech and cephalic presentation.
AB  - Pelvic measurements in a group of 115 women delivering in breech presentation
      were compared with those in a group of 100 delivering in cephalic presentation.
      The average pelvic measurements were all a few mm larger in the breech cases and
      the average sum of the outlet diameters was significantly larger. Pelvic
      disproportion was not more common in breech presentation and no support was found
      for the theory that large pelvic measurements predispose to breech presentation.
      The small differences found are attributed to the moulding of the pelvis
      occurring during parturition.

PMID- 1016510
TI  - Vertebral motion in spondylolisthesis.

PMID- 1016511
TI  - Radiographic measurements on the radio-carpal joint in distal radial fractures.
AB  - Radiography of 40 wrists with fractures in the distal part of radius was
      performed. In the lateral view the inclination of the radial joint surface was
      analysed in different degrees of pronation and supination. The central ray was
      directed 15 degrees proximally and the results were compared with those obtained
      with a perpendicular central ray. In the perpendicular projections even moderate
      differences in pronation or supination between two examinations could seriously
      alter the measured inclination of the joint surface of the radius. The projection
      with the central ray directed 15 degrees proximally highly significantly
      decreased the errors between the measurements when compared to the perpendicular
      projection. The joint surface was depicted more dorsally inclined than in the
      perpendicular projection.

PMID- 1016512
TI  - Thromboresistance and stability of a heparinized polymer.
AB  - Untreated shunts and shunts heparinized according to a modification of the method
      of Eriksson et coll. were inserted between the femoral artery and vein in
      mongrels. Scanning electron microscopy of pieces excised at different time
      periods of exposure to blood was performed. The heparinized surface had excellent
      thromboresistant properties with no thrombus formation after 4 hours, while the
      untreated shunts were covered with platelets already within 20 min. The leakage
      of heparin in vitro was less than 3 per cent of the total wall-bonded heparin
      during 90 min.

PMID- 1016513
TI  - Double-lumen balloon catheter.

PMID- 1016514
TI  - Lipid components of plasma obtained from different sites of rabbit cardiovascular
      system during experimental acute uraemia.

PMID- 1016515
TI  - The effect of calf thymus extract on radiation-induced changes in lysosomal acid
      phosphatase activity in polymorphonuclears in mice.

PMID- 1016516
TI  - Spontaneously increased platelet adhesiveness in multiparous rats--a model for
      the evaluation of antithrombogenic drugs.

PMID- 1016517
TI  - Typology of thermal sweating.

PMID- 1016518
TI  - Quantitative angiographic studies on the left ventricular function in mitral
      stenosis in relation to clinical disability.

PMID- 1016519
TI  - Clinical manifestations and treatment of sick sinus syndrome.

PMID- 1016520
TI  - Low galactose level in the nondialysable sugar-peptide fraction isolated from the
      serum and urine of diabetic patients.

PMID- 1016521
TI  - Low ratio of sialic acid to proteins in the seromucoid of diabetic patients.

PMID- 1016522
TI  - Changes of serum lipid composition in patients with multiple sclerosis.

PMID- 1016523
TI  - The regulation of bronchomotor tone.

PMID- 1016524
TI  - Anticholinergic and beta-sympathomimetic inhalation challenges in asthma and
      bronchitis.

PMID- 1016525
TI  - Review of beta sympathomimetic treatment of asthma.

PMID- 1016526
TI  - [beta-adrenergic drugs on the treatment of bronchial asthma. Use and dangers
      (author's translation)].

PMID- 1016527
TI  - [Prevention of tuberculosis by BCG (AUTHOR'S TRANSLATION)].

PMID- 1016528
TI  - [Hundred eighty tuberculous children treated at home (author's translation)].

PMID- 1016529
TI  - [Occurrence and management of spontaneous pneumothorax (author's translation)].

PMID- 1016530
TI  - [Amyloidosis of the heart (author's translation)].

PMID- 1016531
TI  - [Australia antigen in rheumatoid arthritis].
AB  - Australian antigen (Au Ag) was first described by Blumberg in the serum of an
      Australian aborigen. Its main clinical significance is based on the fact of its
      association with the presence of hepatitis B (Okochi, Nurakami, 1968; Prince,
      1968) (9). Almeida (1969) outlines the intervention of immune complexes on the
      production of the referred illness. Later works show the importance of the type
      of immunologic response created by Au Ag (2). Alpert et al. (1) (1970) state the
      possibility that immune complexes developed by Au Ag and anti Au Ag antibodies
      may produce in patients with hepatitis B other allied manifestations including
      arthritis. On the basis of similar immunopathological findings (illnesses
      including immunocomplexes on their production), Au Ag investigation in rheumatoid
      arthritis (RA) has been the object of several works, whose results reveal certain
      discrepancies. We have investigated the presence of Au Ag on 70 patients whose
      diagnostic was RA "classical (according to the judgement of the American
      Rheumatism Association). We used immunoelectrophoresis (counter
      immunoelectrophoresis-CIEP-) and radioimmunoassay (RIA) techniques. We prepared
      individual records including clinical, epidemic, biochemical and personal data.
      Au Ag investigation both through different techniques gave negative results in 70
      cases, of which only four referred a possible previous hepatitis B clinic
      history, not showing during the investigation suggestive clinical data of
      hepatitis or biochemical alterations. Panus et al. (1970) (5), Desche-Labarte et
      al. (1972), Trempo (1972), Burrel (1973) (6), Serre et al. (1973) (8), obtained
      negative results in the matter, with similar or lower casuistics than ours.
      Notwithstanding Roques et al. (1975) (7), in 300 cases of RA showed the presence
      of Au Ag in a significant number of cases (5%) as compared to Au Ag incidence in
      the French population (estimated in about 0.22%) (6). However, Roques did not
      find in their Au Ag positive cases any evidence which enables to think that this
      antigen has played an important role on the origin and development of the
      rheumatic illness. These important discrepancies may be due to different reasons:
      a) Use of different techniques for Au Ag detection. b) The transitory character
      of the presence of Au Ag in the serum. c) Important differences in the antigen
      geographic distribution. d) Previous hepatitis B. There are som other factors
      which have attained importance recently, as a consequence of the broad
      epidemiological studies carried out. So, Au Ag increased incidence has been found
      -statistically significant--on groups of persons who have been submitted to
      several surgical interventions and/or have needed repeated hospitalizations or
      reiterated blood transfusions (6). These three conditions--especially the first
      two--are accomplished in an illness with chronic and invalidating characteristics
      as RA...

PMID- 1016532
TI  - Cultures of house-dust mites on animal skin scales.
AB  - The main constituent of one of the most suitable media for growing house-dust
      mites (D. pteronyssinus) are human skin scales. In this study it is shown that
      skin scales of a number of other animals are also accepted as food by these
      mites, with evidence of allergen production. Production of house-dust mite
      allergen for diagnosis and treatment should not be done on non-human animal skin
      scales, because of their own high allergenicity.

PMID- 1016533
TI  - The interpretation of total IgE in patients with allergy.
AB  - IgE level was determined by radioimmunosorbent technique (RIST) using Phadebas
      IgE test in the sera of 37 patients with allergic manifestations to inhalant
      agents, foods, drugs and insect stings. High IgE level was found in 90% of the
      inhalant group and in 87.5% of the food group, whilst in the drug and in the
      insect sting groups the incidence was 9.1% and 0%, respectively.

PMID- 1016534
TI  - Why does a tumor grow.

PMID- 1016535
TI  - [Diabetes, pregnancy and labor].

PMID- 1016536
TI  - [Vectorcardiographic studies before and after delivery].

PMID- 1016537
TI  - [Acute hepatic insufficiency as a consequence of disseminated intravascular
      coagulation during pregnancy].

PMID- 1016538
TI  - [Course of pregnancy and birth following caesarea section].

PMID- 1016539
TI  - [Place of cesarean section in pregnant women with heart disease].

PMID- 1016540
TI  - [Our experience with acute renal insufficiency in obstetric-gynecologic
      complications].

PMID- 1016541
TI  - [Diagnostic value of the bromthymol test in amniotic sac rupture].

PMID- 1016542
TI  - [Vacuum-aspiration abrasion--method of choice in gynecologic practice].

PMID- 1016543
TI  - [Colpopoiesis of the pelvic peritoneum--a prospective surgical method].

PMID- 1016544
TI  - [Technic of intrafascial hysterectomy according to Aldridge].

PMID- 1016545
TI  - [Cytogenetic studies of women with menstrual disorders working within range of
      ionizing radiation (external radiation)].

PMID- 1016546
TI  - [Non-specific desensitization in sterile women with proven sperm-antibodies
      against the spermatozoa of their husbands].

PMID- 1016547
TI  - [New more-effective model of intrauterine contraceptive loop covered with copper
      wire--TC 200].

PMID- 1016548
TI  - [Effect of alkalizing therapy on the course, outcome and morphologic changes of
      the idiopathic respiratory distress syndrome in newborns].

PMID- 1016549
TI  - [Rare case of intraligamentous ectopic pregnancy].

PMID- 1016550
TI  - [Hodgkin's disease. Clinical and histopathological aspects].
AB  - Histopathological aspects with relative classification criteria and
      anatomoclinical features are examined in a review of Hodgkin's disease. The major
      classifications proposed are reported and discussed, mention being made of that
      of Jackson and Parker going back to 1944 (paragranuloma, granuloma and sarcoma)
      which provided the starting point for further discussion and research. Through a
      reworking of the calssification of Lukes et al. (1963) this led to the adoption
      of the Rye classification (1965) which distinguished 4 varieties: lymphocyte
      predominance, nodular sclerosis, mixed cellularity, lymphocyte depletion. This
      classification is still accepted by most researchers. The first part of the paper
      is completed by some cytological and microscopic findings. The anatomoclinical
      classification criteria (Rye and Ann Arbor) are then described. The clinical
      aspects of the various localizations, symptomatology and haematological findings
      are examined. Finally, a small personal series is reported, emphasis being laid
      on the fact that often it is only by explorative laparotomy completed by
      splenectomy that it is possible to obtain a definite judgment on the real
      clinical stage of the disease, together with better therapeutic results.

PMID- 1016551
TI  - [Current value of epidemiology of arterial hypertension].

PMID- 1016552
TI  - [Epidemiological data on arterial pressure and hypertension as compiled by the
      Centro per le Malattie Cardiovasculari of the Ospedali Riuniti in Rome].

PMID- 1016553
TI  - [Epidemiological data on arterial pressure and hypertension as compiled at the II
      Clinica Medica of the Padua University].

PMID- 1016554
TI  - [Epidemiological data on arterial pressure and hypertension as compiled by the
      Rome project for the prevention of coronary heart disease].

PMID- 1016555
TI  - [Various comparative data on the distribution of arterial pressure and on the
      prevalence of arterial hypertension in samples of the Italian population].
AB  - After a foreword concerning the present interest for the epidemiology of arterial
      hypertension mainly in relationship with the prevalence of the condition, its
      recognition in the general population and its systematic treatment, three
      separate chapters show the distribution of arterial blood pressure, its mean
      values and the prevalence of hypertension collected by three research groups: the
      Centre for Cardiovascular Diseases, St. Camillo Hospital, Rome, with 8 population
      groups (6929 subjects of whom 447 women, aged 20 to 64, belonging to the city of
      Rome and to other locations of 5 different regions); the II Medical Clinic,
      University of Padua, with 2 population groups (5852 men and women aged 20-64,
      belonging to a defined area of Veneto); the Research Group of the Roman Project
      of Coronary Heart Disease Prevention, with 2 population groups (2611 men aged 40
      59, from Rome). The data provide a description of some characteristics of blood
      pressure and hypertension in different Italian areas and population groups and
      show the existence of large differences in the mean values of blood pressure and
      in the prevalence of hypertension, also within the country.

PMID- 1016556
TI  - [Significance of the electric current characteristics used in rheography. Study
      on the relationship between frequency, voltage and intensity of the current with
      reference to impedance values of the body mass].
AB  - Impedance variations of corporeal segments were evaluated in relation to the
      variations in current frequency and intensity using a tetrapolar measuring
      apparatus. The results appear to confirm the reliability of the technique and, on
      the basis of the study of current transmission in the segment, it is suggested
      that frequencies between 70 and 240 KHz. particularly around 140 KHz, are the
      most suited to this type of measurement.

PMID- 1016557
TI  - [Susceptibility of leukemias with increased antigenicity to immunological lysis].
AB  - Leukaemic sublines obtained following in vivo treatment with antineoplastic drugs
      present increased antigenic properties and these are transmitted in heredity
      after suspension of treatment. The pharmaco-altered sublines are rejected by
      compatible animals with related lymphoma. Susceptibility to humoral and cellular
      immunological lysis on the part of pharmaco-altered sublines with respect to
      related lines has been studied. Lymphocytes of C3HC57Bl/10 mise and non-inbred
      rats immune to histocompatibility antigens of mouse DBA/2 exert the same lysis
      action towards related cells as towards pharmaco-altered cells. The same
      susceptibility to lysis on the part of various cell populations was observed with
      cytotoxic antisera obtained in the same animals. Nor did the immunitary response
      obtained by inoculating the tumours show any different "fragility" to
      immunological lysis. Rejection of the pharmaco-altered sublines does not appear
      to be even partially due to increased fragility with respect to immunitary
      functions.

PMID- 1016558
TI  - [Positive ionotropic action of glucose-1-phosphate. Clinical research during
      heart catheterization].
AB  - The effect of glucose-1-phosphate, administered in a single dose (5 g by slow
      intravenous route), on myocardial contractility was evaluated in a group of
      patients undergoing diagnostic cardiac catheterization. The study of the
      hemodynamic values observed demonstrated that glucose-1-phosphate has positive
      inotropic action and is able to strengthen the effect of the cardioactive
      glucosides.

PMID- 1016559
TI  - [Induced changes of the deflux coefficient, scleral resistance, intraocular
      tension and visual field in eyes subjected to external trabeculotomy].
AB  - Changes in intraocular tension, the visual field, scleral rigidity and the deflux
      coefficient of the aqueous humor following external trabeculotomy indicate that
      this operation is at least as successful as others employed in the management of
      glaucoma.

PMID- 1016560
TI  - [Characteristics of the population which submits to medical check-ups. Analysis
      on a sample of 1000 patients examined in the Italian Diagnostic Center].
AB  - A statistical analysis was made of the historical questionnaires filled in by
      1000 adults subjected to a check-up at the Italian Diagnostic Centre, the aim
      being to assess the medical and social background of persons taking advantage of
      services of this kind.

PMID- 1016561
TI  - [Case of pulmonary fibrosis with normal thoracic x-ray].
AB  - Respiratory performance tests and the gas diffusion data sometimes clinch the
      diagnosis of lung disease when all other findings are negative. A subject with
      cyanosis, dyspnea, drumstick fingers, a normal chest X-ray picture and
      restrictive functional changes accompanied by inefficient diffusion is described.

PMID- 1016562
TI  - [A perinatal mortality sample].
AB  - The Authors consider the cases of delivery occurred in the Clinic of Obstetrics
      and Gynaecology of Parma University in the five-year period 1971-5 and the
      relative perinatal mortality. Whereas fetal mortality during labour has gone to
      be progressively reduced by the modern monitoring techniques, considerable
      importance is still attached to pre-partum fetal mortality. As a result of the
      examination of the causes, EPH Gestosis appears to be the most responsible one
      and the Authors emphasize its inadequate prophylaxis.

PMID- 1016563
TI  - [The diagnosis of adrenal glands adenoma with 131-I 19 iodocholesterol scanning
      (author's transl)].

PMID- 1016564
TI  - [Isotopic study of the C.S.F. hydrodynamic in the Arnold-Chiari malformation
      (author's transl)].
AB  - Six cases of Arnold-Chiari malformation Type I were studied according to the
      following instrumental protocol; skull and atlanto-occipital hinge X-rays,
      including the tomography of these regions, X-rays of the spine, vertebral
      angiography, isotopic cisternography using RIHSA injected intraspinally,
      fractionated pneumoencephalography, Dimer-X ventriculography and iodized
      myelography. The AA emphasize the importance of the cisternographic test with
      radioisotopes for pre-operative and post-operative control of the C.S.F. dynamic.

PMID- 1016565
TI  - [High performance thin-layer chromatography in specific blood diagnosis (author's
      transl)].
AB  - Furthering their research into the differentiation of various haemoglobins (both
      human and animal) with the use of thin layer chromatographic methods, the Authors
      have applied Kaiser's high performance thin layer chromatography (HPTLC) to the
      specific diagnosis of blood. Although the method was superior to ascending one
      dimensional thin layer chromatography for its sensitivity, Rf reproducibility and
      much briefer migration times, it did not turn out to be suitable for application
      to the specific requirements of forensic haematology.

PMID- 1016566
TI  - [Determination of the retention indices (Rf) of hypnotic and anticonvulsant
      sedatives by thin layer chromatography using Merck silica gel plates (author's
      transl)].
AB  - In view of the sometimes considerable differences between absolute retention
      indices (Rf) given in the literature even with the same solvent, same type of
      adsorbent layer and same operating temperature, the Author proposes the adoption
      of a standard method derived from the analytical repeatability of Rf values on a
      thin layer; this would provide a means of searching for a specific parameter by
      which to identify whole categories of drugs, classified according to their
      primary therapeutic activity. The study here covers numerous items in the
      category of hypnotic and anticonvulsant sedatives (barbiturates, non-barbiturate
      hypnotic drugs, hydantoins, suxinimides, and anticonvulsant agents with various
      different structures.

PMID- 1016567
TI  - [Acetylsalicylic acid and platelet aggregation. Clinical study].

PMID- 1016568
TI  - [I.U.D., pregnancy, perforation of the uterus (author's transl)].
AB  - The author report a case of pregnancy reaching as far as the 37th week in a
      patient holding an I.U.D. certainly in site at the beginning of pregnancy and
      with asymptomatic perforation of the uterus during the pregnancy with
      incorporation of the device by the omentum. Emphasis is laid on the importance of
      echographic monitoring for the location of I.U.D.s especially when the anchor
      thread of the device is not to be found in the vagina and initial pregnancy is
      suspected. On the other hand, as yet available data are not sufficient for
      assessing the influence of copper devices on the fetal condition.

PMID- 1016569
TI  - [Catamnestic study of 139 cases maxillo-facial fractures and medico-legal
      considerations (author's transl)].

PMID- 1016570
TI  - [A case of multiple fractures at 4 levels of the upper limb (author's transl)].

PMID- 1016571
TI  - [Combination of corticosteroids and antibiotics in inflammatory conditions of the
      gingivae (author's transl)].

PMID- 1016572
TI  - [Resistance to antibiotics and resistance factors in Salmonella wien strains
      isolated in Sicily].
AB  - The majority of the strains of S. wien isolated in Sicily were resistant to six
      different antibiotics, showing the same resistance pattern (ASKCTSu) observed in
      strains isolated in other provinces of Italy. After conjugation with E. coli K12,
      the transfer of the whole pattern or of various groups of resistances was
      observed, which suggests the presence of several co-existent R plasmids. The
      results obtained suggest that the various outbreaks occurred in Italy have the
      same origin. They can be correlated with the epidemic of S. wien with the same
      transferable pattern of antibiotic resistance, spread in France in recent years
      from Algiers.

PMID- 1016573
TI  - Trace elements and immunologic defects. Zinc deficiency and activity of lysosomal
      acid phosphatase in lymphocyte of mice.
AB  - Activity of lysosomal acid phosphatase in peripheral blood lymphocytes of mice
      fed a low-Zn diet has been studied. The study comprised 40 CBA T6T6 mice, female,
      aged 8 weeks, with body weight equal to about 18.0 g. The animals were fed during
      10 days with a low-Zn diet. This latter diet, as well as the control one
      contained 0.8 mg% and 11.4 mg% of zinc, respectively; potable water contained
      0.06 mg% of this element. Activity of the enzyme was determined
      semiquantitatively using cytochemical method of Barka and Anderson. Peripheral
      blood lymphocytes in mice fed a low-Zn diet exhibited statistically significant
      lowering of the intracellular enzyme activity when compared with control groups.
      Absolute count of enzyme-positive lymphocytes was also significantly lowered. The
      Authors discuss the importance of their observations for evaluation of immune
      reactivity in trace-elements-deficient animals.

PMID- 1016574
TI  - [Positivity frequency for hepatitis B antigen (HBsAg) in sera of healthy
      individuals from a rural center in the Catania province].

PMID- 1016575
TI  - IgG, IgA and IgM concentration in human sera from different age groups:
      statistical evaluation.
AB  - A statistical analysis is presented of the results obtained from the measure of
      the serum concentration of IgG, A, M in 773 blood donors. In each of the two
      groups identified by sex, four subgroups were established according to age in ten
      years intervals from 20 to 59. On the basis of the results of the analysis,
      different fiducial intervals of normal values (calculated as mean +/- 2 X
      standard deviation) have been proposed. 1) A unique interval for IgG: 87-234 U.I.
      2) Two intervals for IgA: 54-236 U.I. for subjects under 40 years and 64-270 U.I.
      for subjects over 40 years. 3) Four intervals for IgM: one for males under 40
      years: 65-364 U.I., one for males over 40 years: 57-314 U.I., one for females
      under 50 years: 47-363 U.I., and one for females over 50 years: 53-434 U.I.

PMID- 1016576
TI  - Administration of antigen by intralymphatic route in the rat I. Humoral response
      to soluble antigens. (delta). Preliminary report.
AB  - Male rats were immunized against bovine albumin injected by either intradermic or
      intralymphatic routes. A significantly higher number of animals treated by the
      latter route did respond, probably because antigens introduced by this route
      directly reach lymph nodes, by passing blood and tissue lytic enzymes.

PMID- 1016577
TI  - The lysosomal enzymes of lymphocytes in human fetuses.

PMID- 1016578
TI  - Effect of non-permissive temperature on protein synthesis of frog virus 3
      infected cells.
AB  - In the present paper we describe the kinetics of virus specific protein synthesis
      in FV3-infected BHK cells incubated at the non-permissive temperature of 33
      degrees C. Some quantitative differences were detected, in comparison with
      proteins synthesized at permissive temperature (26 degrees C). Thereafter we
      studied the fate of polypeptides pulse labelled at non-permissive temperature, by
      shifting the infected cells to permissive temperature. In such experimental
      conditions infectious virus is readily produced; however the profiles of
      electrophoretically separated polypeptides did not differ remarkably from those
      obtained from cells maintained at 33 degrees C.

PMID- 1016579
TI  - [Prevalence of antibodies to A/New Jersey/76, A/Victoria/3/75 and B/Hong
      Kong/5/72 influenza viruses in the population of Milan examined in the late
      spring of 1976 and evaluation of the past experience of the same population with
      probable agent of the 1918-20 pandemics].
AB  - Hemagglutination inhibiting antibodies (h.i.a.) to influenza viruses A/New
      Jersey/76, A/Victoria/3/75 and B/Hong Kong/5/72 were titrated in 227 serum
      samples collected in Milan in the late spring 1976 from healthy subjects of 0 to
      90 years of age. In 185 of these neuraminidase-inhibiting antibodies (n.i.a.) for
      the type A strains were also titrated. Subjects up to 40 years of age lack h.i.a.
      to A/New Jersey/76 strain; antibody levels equal to or greater than 1:40 are
      occasionally present in the 41-50 year group and the incidence rises to 75% and
      more after 60 years. N.i.a. are absent in the sera from persons of 0-30 years and
      titers equal to or greater than 1:100 were found only in the age group over 40.
      Of the sera examined 44% is lacking in h.i.a. to A/Victoria/3/75 strain and
      antibodies at protective levels were found in 14% of the subjects, usually among
      the youngest (0-15 years) and the elderly (over 60 years). N.i.a. for this strain
      are present in 40% of the samples and 10% have titers equal to or greater than
      1.100. Half of the sera under test has h.i.a. to B/Hong Kong/5/72 strain, but
      only 19% with titers equal to or greater than 1:40. The age distribution of h.i.
      and n.i. antibodies to A/New Jersey/76 virus suggests that strains antigenically
      related to the swine virus were widespread in our population until about 1929.
      The presence of n.i.a., but not of h.i.a. in subjects born between 1935 and 1946
      supports the hypothesis of cross-reaction between the neuraminidases of the swine
      and of the A-O strains.

PMID- 1016580
TI  - [Evaluation of the immunity to A/swine influenza virus in a sample of population
      of Rome].
AB  - Hemagglutination-inhibiting (HI) antibodies in respect of type A/swine influenza
      virus (strain NIB/3) were titrated on 225 serum specimens taken in Rome during
      1976. No HI antibodies to the A/swine virus were found in the serum specimens of
      the 155 subjects under 50 years of age, while the majority (94%) of the serum
      specimens of the subjects over 70 years of age showed HI antibody reactivity to
      the virus, with a mean geometric titre of 21.75. The vaccination of 38
      individuals over 50 years of age with live attenuated influenza virus (strain
      H3N2 - A/Port Chalmers/1/73) failed to cause any elevation of HI antibody titres
      against A/swine influenza virus, though producing significant seroconversion in
      respect of the A/Port Chalmers influenza virus in more than 60% of the vaccinees.

PMID- 1016581
TI  - [Complement fixation, hemagglutination inhibition and neuraminidase inhibition
      reactions in the seroepidemiologic evaluation of an influenza A epidemic].
AB  - Complement-fixing (CF), hemagglutination-inhibiting (HI) and neuraminidase
      inhibiting (NI) antibodies in respect of type A influenza virus were titrated on
      2080 serum specimens. The sera were collected between December 1974 and May 1975
      for the open population of Rome, in groups of an average of 300 samples per
      month. Influenza type A strains, related to the Port Chalmers variant, were
      isolated in Rome in January and February 1975, during that time a significant
      increase of antibody titers and of serum positivity was detected. The increase of
      positive response for influenza type A antigen was of 21%, 17% and 8% for FC, HI
      and NI reactions, respectively. The NI reaction proved to be less responsive that
      the CF and HI reactions for the purposes of sero-epidemiological evaluation of
      the influenza epidemic.

PMID- 1016582
TI  - [Methods for identification of rhodochrous bacterial complex].
AB  - Branching observation, color and emulsionability of colonies, growth on BHI-agar,
      Mc Conkey-agar, Sabouraud, Mannitol Salt-agar, galattosidase, degradation of
      polyethylene glicol in 7H-10 medium, drug sensitivity to antituberculous drugs
      and semi-synthetic penicillins are reactions able to differentiate the
      rhodochrous complex from pathogenic pigmented Mycobacteria and Nocardia.
      Numerical taxonomy performed among 14 strains belonging to rhodochrous complex
      and 17 strains of Nocardia revealed a distinct separation of the two species and
      the non omogeneity of rhodochrous complex.

PMID- 1016583
TI  - An improved method for PHA-culturing mouse lymphocytes using Ficoll-Hypaque
      gradient.
AB  - A simple, reproducible method is described for in vitro culture of mouse
      lymphocytes purified by differential centrifugation through Ficoll-Hypaque
      gradient. Peripheral blood, spleen and thymus purified lymphocytes responded well
      to in vitro PHA stimulation as measured by blast transformation and tritiated
      thymidine incorporation; the lowest values were observed with thymus lymphocytes.

PMID- 1016584
TI  - Phytohemagglutinin unresponsiveness of spleen cells of mice bearing an allogeneic
      lymphoma.
AB  - The in vitro response of spleen cells to phytohemagglutinin (PHA) was studied in
      BALB mice bearing an allogeneic AKR lymphoma (progressors). A significant
      decrease in blast transformation and DNA synthesis was observed in these animals
      as compared with those rejecting the tumor (regressors) or with unchallenged
      controls. It is postulated that either an alteration in PHA lymphocyte receptors
      or the presence of enhancing serum factors may be responsible for this decrease
      in PHA response.

PMID- 1016585
TI  - [Demonstration of a granulocyte defect in aged persons correlated with the
      presence of autoantibodies].
AB  - Assessment of PMN leukocyte function and search for autoantibodies were performed
      in 36 aged human subjects (more than 60 years of age) and in 15 younger controls
      (40 to 60 years of age). Autoantibodies were found in 15 of the 36 aged subjects,
      and in none of the controls. Leukocyte function defects were therefore correlated
      to old age and to markers of autoimmunity. Phagocytosis of bacteria was
      significantly impaired in both groups of old-aged subjects, irrespective to the
      presence or absence of autoimmunity. Intracellular killing of bacteria was shown
      to be normal in all the examined subjects. Nitroblue tetrazolium reduction by
      resting and latex-stimulated leukocytes was significantly impaired only in the
      group of old-aged subjects with autoimmunity. These leukocyte function defects
      are similar to those already described in human autoimmune diseases --
      particularly S.I.E. -- and confirm the possible association between P.M.N.
      dysfunction and autoimmunity.

PMID- 1016586
TI  - [Infection due to hepatitis B virus and host immune response].
AB  - Cell-mediated immunity (CMI) to hepatitis B surface antigen (HBsAg) was
      investigated in patients who recovered from acute hepatitis B and in chronic
      carriers of the antigen, either with or without liver disease. The study was
      performed using leucocyte migration inhibition test and purified HBsAg. In
      antigen-negative post-hepatitis patients the frequency of cellular immunity to
      HBsAg (63.6%) showed a significant difference to controls. On the other hand,
      only one out of 5 antigen-positive post-hepatitis patients showed sensitisation
      to HBsAg; four out of these cases had chronic hepatitis at liver biopsy. In HBsAg
      chronic carriers, with or without liver disease, the frequency of CMI to HBsAg
      was not significant to controls. A significant correlation was noted between
      inflammatory activity and inhibition of migration. Our results suggest that a
      normal cellular immune response to HBsAg is necessary for the recovery from acute
      hepatitis B and for the clearance of the virus. In HBsAg-chronic carriers this
      response seems to be absent or inadequate, leading to the state of healthy
      chronic carriers or to the evolution to HBsAg-chronic hepatitis, respectively.
      The high frequency of CMI in HBsAg-negative chronic active hepatitis, suggests
      that hepatitis B virus infection may play a role in the ethiology of the disease.

PMID- 1016587
TI  - [The sexual transmission of Australia antigen (HBsAg)].
AB  - Examination was made of 300 serum specimens taken from patients with latent
      syphilis, in order to study the incidence of HBsAg antigen as compared with the
      normal population. Examination was by means of counter immunoelectrophoresis,
      radioimmunoassay and electron microscope with negative staining. The incidence as
      shown by counter immunoelectrophoresis is 2.33%, by RIA 10% with 86.6% of sub
      type AY and 13.3% of sub-type AD, which is significantly higher than the
      incidence in the normal population. These data would therefore seem to confirm
      the possibility of sexual transmission of hepatitis B.

PMID- 1016588
TI  - Ultrastructural aspects of Peptichemio action on mouse sarcoma 180.
AB  - The electron microscope study of the cellular elements originating from mice
      experimental tumours (sarcoma 180) treated and non-treated with Peptichemio
      showed alterations of the nuclear and cytoplasmic structures in the animals
      treated. The data herein accord fully with the results obtained by other
      histological, biochemical and biomolecular techniques and make it possible once
      again to lay stress on the double alkylating and antimetabolic action of this
      antitumour drug, very likely taking place simultaneously both at nuclear and
      cytoplasmic level.

PMID- 1016589
TI  - [The coagulase test. I].
AB  - A syntetic review of data about the free coagulase and the clumping factor has
      been made. The importance of the test, the different methods, the possible
      reasons of mistake are discussed.

PMID- 1016590
TI  - Immunization against human and swine-like influenza A: serological response to
      two inactivated vaccines of different formulation.
AB  - The immunizing capacity and the tolerability of two purified vaccines containing
      the inactivated A/New Jersey/76 ( x 53 recombinant) swine-like strain were
      studied. A trivalent vaccine (A/New Jersey/76-300 I.U.; A/Victoria 3/75-300 I.U.;
      B/Hong Kong 5/75-300 I.U.) was administered to 31 subjects over 50 years of age.
      No side-effects were observed and it caused a good HI antibody response to A/New
      Jersey/76, fairly good for B strain and modest for A/Victoria 3/75. A monovalent
      vaccine (A/New Jersey/76-400 I.U.) was administered to 32 subjects in the age
      range from 16 to 43 years. HI antibodies occurred in 84% of the subjects, devoid
      of antibodies before vaccination. Younger subjects (between 16-20 years)
      generally developed fairly low antibody titres; one among them (16-year-old) had
      a temperature rise within 48 h after vaccination. The Authors expect that the X
      53 recombinant with the surface antigens of the A/New Jersey/76 strain may be
      employed for the preparation of the inactivated vaccine to be used in an
      emergency situation and discuss the composition of the vaccine more adapt for the
      present epidemiological situation.

PMID- 1016591
TI  - With reference to a simple kit for short-term lymphocyte culture tested in
      experimental animals.
AB  - The results on blastic transformation of peripheral-blood lymphocytes from
      different species of experimental animals studied in short-term cell culture made
      with a fully pre-prepared Kit, are here illustrated and discussed. Lymphocyte
      donors were: mice, rats, hamsters, guinea-pigs, and rabbits. The Kit used in
      these experiments was the so-called Blasto-Kit, prepared by the Istituto
      Sieroterapico Milanese. It contains a lyophilized mixture of all the culture
      medium components, including the mitogen (in our study: PHA). The lyophilized
      mixture was diluted with the proper solvent just at the culture time, and then
      supplemented  with 5 drops (200 mul) of whole blood. The extent of blastic
      transformation was evaluated in morphology, by counting the blast-like cells on
      culture smears; but the method provides adequate data also when lymphocyte
      transformation is evaluated via the extent of 3H-Tdr incorporation. The results
      showed quite significant discrimination (blastic indices) between the mitogen
      stimulated cultures and the non-stimulated controls in all the animals tested. On
      the other hand, different transformation extents were observed in relationship to
      the single animal species: it appeared that guinea-pigs, and mostly the rabbits
      gave the most beautiful blast-like cells, which appears to indicate that they are
      the most appropriate for this study among all those tested. It should be finally
      emphasized that : (1) the simplicity of the method makes the investigation on the
      transformation capability of lymphocytes easy to be carried out in every Lab; and
      (2), the small quantity of blood which is needed to perform the test makes it
      possible to investigate each single animal even in the case, when it has to be
      examined before, during, and after given treatments.

PMID- 1016592
TI  - [Liver-specific proteins and autoimmunity in inflammatory liver diseases].
AB  - Cell-mediated immunity to a liver specific membrane protein (LP1) has been
      studied in patients with different types of liver diseases, using the leucocyte
      migration inhibition test. A high frequency of cellular sensitization to LP1 was
      detected in untreated chronic active hepatitis, with no significant differences
      between HBsAg-positive and negative cases. Inhibition of migration is a long
      lasting reaction in the spontaneous evolution of the disease, while
      immunosuppressive treatment normalizes the test only in cases with complete
      remission. In viral hepatitis B cell-mediated immunity to the liver specific
      membrane protein can be detected in the acute phase of the disease as a time
      limited reaction, exhausted with the clearance of the virus from the liver. An
      inhibition of migration with LP1 was found also in some cases of HBsAg-positive
      post-hepatitis patients, in chronic persistant hepatitis, mainly HBsAg-positive,
      and in asymptomatic chronic carriers of the antigen B. Most of these cases showed
      a progression to chronic active hepatitis, in clinical and histopathological
      prospective studies. Our results suggest that cell-mediated immune response to
      liver specific antigens plays a major role in the pathogenesis of chronic active
      hepatitis. Moreover the evaluation of these reactions in chronic liver diseases
      may help in the diagnosis and in the control of the immunosuppressive therapy.
      Hepatitis B virus infection must be considered one of the possible cause
      responsible for the rising of autoimmunity to the liver.

PMID- 1016593
TI  - Peripheral lymphocytes in paraproteinemia.
AB  - In 22 cases of myeloma and 12 cases of benign paraproteinemia the functional
      situation of circulating lymphocytes was studied. The technique used was the
      incorporation of 3H-Thymidine after PHA stimulation. E rosette formation and
      immunoglobulin bearing cells were evaluated. A reduction of 3H-Thymidine
      incorporation in the blastic cells was seen in the patients with myeloma (2,942
      +/- 421 cpm/10(6) lymphocytes in respect to 13,182 +/- 920 of the control group).
      The difference was statistically significant: p less than 0.001. In benign
      monoclonal gammopathies the reduction was moderate and was at the limits of the
      significance: 9,482 +/- 1,100. The percentage of E rosettes and of
      immunoglobulins bearing cells was normal. The different behaviour of the blastic
      response in vitro in the two groups of patients tested confirms that the
      respective condition of the immunocompetent system is clearly different. A
      possible interpretation of this type of behaviour is discussed.

PMID- 1016594
TI  - [Anti-inflammatory agents and lymphocytary reactivity].
AB  - The acetylsalicylic acid, like other drugs with analogous properties, is an anti
      inflammatory drug, whose mechanism of action is still unknown. Lymphocyte
      release, on stimulation, phlogogenic substances (lymphokines) which are
      responsible for some phlogistic processes, above all chronic. Acetylsalicylic
      acid inhibits some lymphocyte functions, therfore its mechanism of action may be
      possibly accounted for by this activity. This paper dealt with the effect
      observed that acetylsalicylic acid on mitogen-induced lymphocyte blastization. In
      vitro it was observed that acetylsalicylic acid inhibits blastization only when
      it is present in the incubation medium and that the inhibitor effect is dose
      dependent. In vivo, in the rat, it was observed that acetylsalicylic acid
      inhibits blastization only when administered some hours before lymphocyte
      withdrawal. The Authors believe that this effect may be accounted for by a
      metabolite of the drug itself.

PMID- 1016595
TI  - [Sensitization to metals in patients submitted to arthroplasty].
AB  - The sensitization of the patients submitted to arthroplasty has been pointed out
      with increasing frequency. This paper attempted to establish the occurrence rate
      and the importance of this sensitization in patients submitted to arthroplasty of
      metallic or plastic type, by means of the patch-test, blastization and macrophage
      inhibition test. The highest positivity incidence was observed towards chromium
      (9.7%) and cobalt (6.4%) in the patients submitted to arthroplasty of metallic
      type, while that of plastic type showed a 1% positivity to methylacrylate. These
      data stress the importance of the adoption of the patch-test in all patients,
      before being submitted to any type of prosthesis, and of the preferential use of
      those prostheses which turned out less sensitizing.

PMID- 1016596
TI  - Limulus test, parenteral drugs and biological products: an approach.
AB  - The Authors report the results concerning the control of the presence of
      bacterial endotoxins in parenteral drugs, blood products and immunological
      reagents and drugs, by means of Limulus amebocyte lysate test. All the data
      suggest that Limulus assay is a simple, rapid, sensitive test, mostly when it is
      correctly performed.

PMID- 1016597
TI  - Introduction to HPLC.

PMID- 1016598
TI  - [Technology of pharmaceutic powders: tablets produced using a special
      technology].

PMID- 1016599
TI  - [Use of rheologic analysis in the study of physical stability of antibiotic
      suspensions].

PMID- 1016600
TI  - [Rapid method for the detection and identification of cannabinols in Cannabis].

PMID- 1016601
TI  - [Lactulose: pharmacodynamic evaluation].

PMID- 1016602
TI  - [Comparative research on the absorption of paracetamol and aminophenazone in man
      after oral or rectal administration].

PMID- 1016603
TI  - [New synthesis of derivatives of the quinoline nucleus].

PMID- 1016604
TI  - [Nitrofurantoin: dimensions of crystals and biologic availability].

PMID- 1016605
TI  - [Optical resolution and configuration of 1-aminobenzocyclobutene and 1
      aminoindane].

PMID- 1016606
TI  - [In-vitro study on the diffusion velocity constants of p-2-(n-octyloxy)-benzoyl
      aminobenzoate of N-diethylmethylammonioethyl bromide].

PMID- 1016607
TI  - [Determination of fluocinolone acetonide in a dermatologic cream using
      differential UV spectrophotometry].

PMID- 1016608
TI  - [Examination of parameters which could influence the functioning of industrial
      autoclave for steam sterilization].

PMID- 1016609
TI  - [Ascending curves of new products: an instrument of marketing].

PMID- 1016610
TI  - [Technology of pharmaceutic powders: direct compression].

PMID- 1016611
TI  - Urinary elimination of dihydro-ergotoxine after oral administration and
      intravenous infusion.

PMID- 1016612
TI  - [Condensation of 2,3-dimethyl-4-carbetoxyisoxazoline-5-one with aromatic
      aldehydes].

PMID- 1016613
TI  - Mucosecretolytic effect of 1-methyl-4-(2-hydroxy-isopropyl)-cyclohex-1,2-en-6-ol
      (sobrerol) in the rabbit.

PMID- 1016614
TI  - On the characteristics of diluents for direct compression.

PMID- 1016615
TI  - [Lactulose: toxicological evaluation].

PMID- 1016616
TI  - [Introduction to high-speed liquid chromatography (HSLC)].

PMID- 1016617
TI  - [Technology of pharmaceutic powders: dry and humid granulation].

PMID- 1016618
TI  - [Interaction of formebolone and natural cortico-adrenal extracts].

PMID- 1016619
TI  - [Absorption and distribution of vitamin A (11,12)-H3 acetate introduced via the
      rectum to the rabbit].

PMID- 1016620
TI  - [Pharmacological research on a deethylate metabolite of 4-amino-5-chloro-N-(2
      diethylaminoethyl)-2-methoxybenzamide (metoclopramide)].

PMID- 1016621
TI  - The effect of some wetting agents on the characteristics of suspensions of
      sulfamethoxypyridazine and its "N1-acetyl derivative.

PMID- 1016622
TI  - [Preliminary observations on the characterization of a microbial strain isolated
      from mud and active in saline medium with added phenanthrene].

PMID- 1016623
TI  - Histochemical method to detect antiproteolytic activity in tissues.

PMID- 1016624
TI  - Antiproteolytic activity in human coronary arteries affected by long-dating
      atherosclerosis.

PMID- 1016625
TI  - Antiproteolytic activity in human placenta and decidua.

PMID- 1016626
TI  - Antiproteolytic activity in foetal organs with low fibrinolytic potential.

PMID- 1016627
TI  - Antiproteolytic activity in foetal organs with high fibrinolytic potential.

PMID- 1016628
TI  - [Interference of Hymenolepis nana parasitosis on body weight development in
      mice].

PMID- 1016629
TI  - [Positive correlation between nuclear volume and cell growth in the chicken
      feather].

PMID- 1016630
TI  - [Repeated arousal during non-REM sleep in normal humans. Changes in anxiety,
      depression and aggressiveness and HVA and 5-HIAA levels in the lumbar
      cerebrospinal fluid].

PMID- 1016631
TI  - [Total sleep deprivation in normal humans. Changes in anxiety, depression and
      aggressiveness and HVA and 5-HIAA levels in the lumbar cerebrospinal fluid].

PMID- 1016632
TI  - [Homovanillic acid (HVA) and 5-hydroxyindoleacetic acid (5-HIAA) levels in the
      lumbar cerebrospinal fluid in epileptic patients].

PMID- 1016633
TI  - [Effects of vinblastine and vincristine on the innervated rat stomach].

PMID- 1016634
TI  - [Inhibition by agaric acid of citrate transport in mitochondria].

PMID- 1016635
TI  - [Effect of an anticholinergic drug, biperiden, on serum prolactin levels in
      humans].

PMID- 1016636
TI  - [Preliminary observations on the transfer RNA content of the rat liver during
      differentiation and growth].

PMID- 1016637
TI  - [Peripheral pulmonary flow in hypervolemia].

PMID- 1016638
TI  - [Pulmonary and peripheral arterial flow in hypovolemic shock].

PMID- 1016639
TI  - [Changes in pulmonary artery and carotid flow in hypovolemic shock].

PMID- 1016640
TI  - [Changes in pulmonary, renal and mesenteric arterial flow in hypovolemic shock].

PMID- 1016641
TI  - Pressure antagonism of anaesthetic-induced conduction failure in frog peripheral
      nerve.
AB  - Experiments to investigate pressure-induced antagonism of the effects of general
      anaesthetics in isolated peripheral nerve from the frog are described. The doses
      of four gaseous general anaesthetic agents required to reduce electrically evoked
      action potentials by 50% (mean +/- SEM) were nitrous oxide 490 +/- 40.4 kPa,
      ethylene 665 +/- 212 kPa, dichlorodifluoromethane 108 +/- 17.2 kPa and
      cyclopropane 70 +/- 5 kPa. The combination of high pressure and the anaesthetic
      agent partially or completely restored the action potential amplitudes for the
      gaseous and some of the volatile agents (chloroform, diethyl ether, helothane).
      However, reversal of the effects of other volatile agents (ethanol, butanol),
      sodium pentobarbitone and two local anaesthetic agents (procaine, dibucaine) did
      not occur. The pressures used to effect a reversal were less than anticipated.
      This apparent inconsistency with the critical volume hypothesis for anaesthesia
      is discussed.

PMID- 1016642
TI  - The effect of splenectomy on circulatory adjustments to hypoxaemia in the
      anaesthetized dog.
AB  - Six intact and seven splenectomized dogs were subjected to a similar degree of
      hypoxaemia while under light anaesthesia and artificial ventilation. In the
      intact animals, heart rate, cardiac output, myocardial contractility and oxygen
      consumption were increased as a result of hypoxaemia; oxygen transport was not
      affected. In the splenectomized animals the changes in cardiac output and
      myocardial contractility were small, and oxygen availability was decreased.

PMID- 1016643
TI  - A further study of general anaesthesia for Caesarean section.
AB  - Methoxyflurane or trichloroethylene in concentrations of 0.2% or 0.1% used in
      anaesthesia for Caesarean section were compared. There were no differences in the
      acid-base state or the clinical condition of the infant at delivery, or in the
      incidence of maternal complications, which could be related to the choice of
      volatile agent. Either volatile agent in the 0.2% concentration was associated
      with an overall incidence of maternal awareness and unpleasant dreams of 2.5%,
      compared with 4.9% when the 0.1% concentration was used. The incidence of
      maternal nausea and vomiting was less in the 0.2% series. There was an apparent
      relationship between the induction-delivery interval and (a) the degree of
      neonatal acidosis and (b) the Apgar-minus-colour scores at one minute ((A-C)1).
      The correlation between those indices of increasing foetal depression and
      increasing length of the uterine incision-delivery interval was highly
      significant. There was no systematic relationship between the one-minute score
      for "colour" and the umbilical artery PO2.

PMID- 1016644
TI  - Haemodynamics and myocardial oxygen consumption during isoflurane (forane)
      anaesthesia in geriatric patients.
AB  - The influence of isoflurane on haemodynamics and myocardial oxygen consumption
      was examined in seven geriatric patients under conditions of controlled
      ventilation and a normal arterial carbon dioxide tension. During
      isoflurane/nitrous oxide in oxygen anaesthesia (0.75 and 1.5 vol% inspired
      isoflurane) no significant changes occurred in cardiac output, stroke volume,
      heart rate, central venous and pulmonary artery pressure. Arterial pressure
      decreased, as did total peripheral resistance. A reduction in left ventricular
      maximum dp/dt (18-39%) was, at least in part, a result of changes in loading
      conditions. Total body (CaO2--CVO2) and base excess values remained within the
      normal range. We consider that the oxygen supply was adequate to meet the
      metabolic demands of the body as a whole. Myocardial oxygen consumption decreased
      by 25% during 0.75 vol% inspired isoflurane and by 43.5% with deepening of
      anaesthesia (1.5 vol% isoflurane).

PMID- 1016645
TI  - Pharmacokinetic analysis using an electrical analogue.
AB  - After i.v. administration, the distribution and elimination of many drugs may be
      simulated by a compartmental mathematical model. The analogue can be used to
      construct such models in electrical terms. When programmed with an appropriate
      model, the analogue can be used in a wide range of predictive studies. The
      application of the analogue is illustrated by analysis of serial plasma
      concentrations of fentanyl and pancuronium.

PMID- 1016646
TI  - Tubocurarine and the neonate.
AB  - Tubocurarine, given as a single bolus, may be used safely for neuromuscular
      blockade in the neonate. The recommended dose is 250 mug/kg at birth, increasing
      to 500 mug/kg at 28 days of age. This dose should be reduced in the event of
      prematurity, acidosis or hypothermia, or when certain antibiotics or inhalation
      anaesthetic agents are present in the tissues. A single dose as described has a
      duration of approximately 1 h and it is only after this time that satisfactory
      antagonism can be obtained. The potency of pancuronium when compared with
      tubocurarine in the study is 6:1, from birth to 28 days.

PMID- 1016647
TI  - Laryngeal incompetence during neuroleptanalgesia in combination with diazepam.
AB  - In eight patients, following carotid angiography under neuroleptanalgesia, a
      radiopaque dye was instilled into the pharynx. The chest was x-rayed 15 min
      later. All eight patients were observed to have aspirated the dye. The technique
      of neuroleptanalgesia described should not be used without safeguarding the
      airway in patients liable to regurgitate and inhale gastric contents.

PMID- 1016648
TI  - Tetany, tetanus or drug reaction? A case report.
AB  - An 8-year-old child was given perphenazine to prevent vomiting after surgery and
      developed an acute dystonic reaction; There were features of both tetany and
      tetanus without any of the classical features of extrapyramidal disturbance. The
      diagnostic difficulties are discussed. The reaction was treated successfully with
      i.v. diazepam. The prescribing of anti-emetics after surgery is examined
      critically with special reference to children.

PMID- 1016649
TI  - Hypersensitivity to suxamethonium in a Suffolk family.
AB  - Suxamethonium apnoea developed in a patient who was a homozygote for the atypical
      gene. Fifty-five members of the patient's family were investigated. Seven further
      homozygotes were found. Suxamethonium apnoea had been demonstrated previously in
      one of these. Thirty-two members of the family were heterozygotes.

PMID- 1016650
TI  - [Purification of alpha-amylase by affinity chromatography on cross-linked
      starch].
AB  - Affinity chromatography on cross-linked starch affords a simple and rapid
      procedure for alpha-amylases (EC 3.2.1.1.) purification. When starch is cross
      linked in alkaline medium by epichlorhydrin in the conditions described, the
      insoluble polysaccharide obtained is able to retain specifically the alpha
      amylase which is then eluted with 2M maltose solution. alpha-amylase can be
      obtained in a pure form with a 60% yield. The exoenzyme beta-amylase (EC 3.2.1.2)
      is not retained by the support and is eluted with other contaminant proteins.
      Therefore, this procedure allows the separation of the endo- and exoamylase
      activities.

PMID- 1016651
TI  - [Primary structure of the casein macropeptide of caprine kappa casein].
AB  - The amino acid sequence of caprine CMP, the negatively charged C-terminal
      fragment released by chymosin (rennin EC 3.4.23.4) from goat K-casein at the
      initial stage of the milk-clotting process, has been investigated. The complete
      sequence has been determined by analysing chymotryptic and "thermolysin"
      fragments of the CMP. Caprine CMP contains 66 amino acid residues, 2 being
      phosphorylated. Asp2, Asn5, Thr11, Ser6, SerP2, Glu7, Gln2, Pro6, Ala9 Val5,
      Met1, Ile6, Lys3, His1, and the carbohydrate-free polypeptide chain has a
      molecular weight of 6,998 daltons. The occurrence in caprine CMP of an additional
      phosphate group, linked to serine 168 in the C-terminal region Thr-Ser168-Thr
      Glu170-Val.OH of the polypeptide chain, has given support to the phosphorylation
      code for caseins that we postulated earlier [28, 27]. According to this
      hypothesis, a specific phosphoryl kinase may recognize an anionic phosphorylation
      site corresponding to the tripeptide sequence Thr/Ser-X-Glu, X being any amino
      acid residue. Since the C-terminal sequence of bovine and caprine CMPs differ by
      the substitution Ala/Glu170 (caprine), phosphorylation of caprine serine 168
      could be explained by the occurrence of the new phosphorylation site Ser168-Thr
      Glu170.

PMID- 1016652
TI  - [Preparation and immunoephelometric quantitation of fibrinogen in rabbits].
AB  - Pure rabbit fibrinogen was prepared by a method involving two ammonium sulfate
      precipitations, one 2 M phosphate buffer precipitation, one DEAE cellulose
      chromatography and lastly one Sepharose 6 B chromatography. The aminoacid
      composition was determined and an immunonephelemetric assay was proposed. This
      assay followed an accurate determination of fibrinogen concentration in a rabbit
      with inflammatory reaction.

PMID- 1016653
TI  - Transfer ribonucleic acid methylase activity in adult and foetal rat liver.
AB  - Foetal rat liver extracts were found to have higher tRNA methylene activities
      than corresponding extracts of adult liver. When the specific activities were
      expressed per mg of liver or per mg of protein, the foetal tRNA methylating
      enzymes were respectively 2.5 and 6 times higher than those of adult livers. The
      presence of an inhibitor in adult liver can be excluded, since the same
      recoveries of total tRNA methylase activity were obtained after partial
      purification of both adult and foetal liver extracts: yields were close to 100%.
      The apparent Km's for the substrates in the methylating reactions were the same
      when tRNA methylases from either adult or foetal liver were used: values were 0.2
      muM for Escherichia coli tRNA and 2.1 muM for S-adenosyl-L-methionine. After T1
      T2 ribonuclease digestion of an in vitro methylated tRNA, similar methyl
      nucleotide patterns were observed in foetal and adult enzymatic extracts. It is
      concluded that the same tRNA methylase pool is present in adult and foetal liver.
      In addition, it is hypothesized that the different reaction rates exhibited by
      these enzymes might be due to the tRNA functional requirements rather than to the
      presence of a tRNA methylase inhibitor.

PMID- 1016654
TI  - [Biological methylations in the crab Carcinus maenas; in vitro inhibition by a
      fraction purified from androgen gland extracts].
AB  - Extracts from muscles, testis, seminal vesicles and ovaries of the Crab, Carcinus
      maenas, have been studied in vitro, in presence of [14C]-methyl S
      adenosylmethionine, with an E. coli tRNA as methyl acceptor. The highest level of
      methylases is found in the testis. It has been reported previously that a
      purified fraction extracted from the androgenic glands of Carcinus maenas
      inhibits the vitellogenesis in ovaries. We now show that the same fraction
      inhibits tRNA methylation in an extract of testis as methylase; a 50% inhibition
      is obtained with about 10 mug of a purified fraction corresponding to 15 glands.
      With an enzymatic preparation from the ovaries, a 50% inhibition of the tRNA
      methylase is observed with the purified extract from 4 glands.

PMID- 1016655
TI  - [Structure, amount and composition of sulfuric, sulfonic and phosphoric esters of
      glycosyldiglycerides of three fucacea].
AB  - The mono and polyester glycosyl sulfates or phosphate diglycerides account for a
      group of polar lipids which is found in large amounts in the three fucacae that
      are studied: Pelvetia canaliculata (L) Deen and Thur, Fucus vesiculosus (L),
      Fucus serratus (L).  These polar lipids have been shown to have complex
      structures, most of them are unknown in the present nomenclature. Both quantity
      and composition of these polar lipids are species characteristics, forming the
      equipment of polar lipids for every species of algae. Glycosyl ester sulfate and
      phosphate diglycerides are very unstable substances when pure, moreover
      photolabile and thremodegradable. This extreme fragility caused many difficulties
      in the determination of molecular structures which require a very high purity of
      isolated substances, The determination of the structures, studies of quantities
      and composition cytological localization of these polar lipids should allow to
      define clearly their physiological function and importance from the biochemical
      and ecological point of view.

PMID- 1016656
TI  - [Aliphatic alcohol sulfates: new polar lipids isolated from various Fucacea].
AB  - Four new sulfolipids have been found in the three Fucacea from the coast of
      Britany P. canaliculata (L) Deen et Thur, F. vesiculosus (L), F. serratus (L).
      These four polar lipids form a separate group, their structures being very
      different from those of the glyceride by-products already known. By acid
      hydrolysis of these substances the aliphatic mono and dialcohols can be
      separated. The aliphatic hydrocarbons studied by gas chromatography and
      spectrometric methods (IR, MASS), have been established as being saturated C30
      mono or dialcohols, saturated C18 and C20 monoinsaturated dialcohols. SAA are the
      only substances found: there was no sulfonate or phosphate ester in the three
      algae studied. The quantity and composition of SAA are not characteristic of the
      species. Their variations depend on the physiological and biochemical states of
      the thallus and on the conditions of extraction and purification.

PMID- 1016657
TI  - [Purification and properties of catechol-0-methyltransferase (EC.2.1.1.6) from
      human placenta].

PMID- 1016658
TI  - [Use of polyethylene glycol for the precipitation of a hormone-antibody complex
      in radioimmunologic determination of rat gonadotropins].

PMID- 1016659
TI  - Purification and structure of arginase of Bacillus licheniformis.

PMID- 1016660
TI  - A sensitive radioimmunoassay for prostaglandin E2 using dialysis equilibrium.

PMID- 1016661
TI  - [A new method for the preparation of hemopexin from rats].

PMID- 1016662
TI  - Ocular development and involution in the European cave salamander, Proteus
      anguinus laurenti.
AB  - The anatomy and development of the eye of Proteus anguinus are described. The
      relationships between organogenesis of the eye in embryos and larva and its
      involution in the young and the adult are discussed. The availability (in
      breeding cultures) of a significant number of Proteus embryos (which are normally
      rare) allowed experimental analysis of the effects of light, xenoplastic
      differentiation and thyroid hormones on the development of the eye. The results
      of this study suggest that development and involution of the eye of Proteus are
      controlled by genetic factors which are not greatly influenced by environment,
      and one can, therefore, consider the microphthalmy of Proteus as a relict
      characteristic which is the result of a specific development with disturbance of
      the normal ontogenic process.

PMID- 1016663
TI  - Observations on the feeding mechanism, diet and digestive physiology of
      Histriobdella homari Van Beneden 1858: an aberrant polychaete symbiotic with
      North American and European lobsters.
AB  - 1. The aberrant annelid Histriobdella homari (Polychaeta:Eunicida) lives in the
      branchial chambers of the marine lobsters Homarus americanus and H. vulgaris
      where it feeds on the rich microflora of bacteria, blue-green algae and related
      organisms which grow on the inner surface of the branchial chamber, the setae
      fringing the edges of the carapace, the gill filaments and, especially, the
      surfaces and setae of the epipodite plates between the gills. H. homari,
      therefore, is to be regarded as an epizoic microphagous cleaning symbiote of the
      lobsters. 2. The alimentary canal consists of mouth, buccal cavity, oesophagus,
      proventriculus, stomach, intestine and anus. The much-modified proboscis lies
      ventrally below the oesophagus and proventriculus, with its anterior portions
      protruding into the rear of the buccal cavity. 3. The proboscis consists of two
      fixed parallel mandibles, a transverse carrier which slides upon the mandibles
      and to which is attached, posteriorly, a median flexible dorsal rod and,
      anteriorly, four pairs of movable articulated maxillae, paired external and
      internal retractor muscles and various tensor, flexor and extensor muscles. 4.
      Contraction of the retractor muscles withdraws the carrier and maxillae
      posteriorly, causing bowing of the dorsal rod which is fixed at its posterior
      end. Relaxation of the muscles allows the rod to straighten and, thus, causes
      protraction of the carrier and protraction and lateral expansion of the maxillae.
      Contraction and relaxation of the relaxation of the retractor muscles are
      supplemented by appropriate changes in the other muscular components of the
      proboscis. 5. During feeding the serrated anterior ends of the mandibles are
      applied to the food, the maxillae are fully expanded and then dawn ventro
      posteriorly toward the mid-line by contraction of the retractor muscles in the
      effective movement of the feeding mechanism. This draws the food organisms across
      the anterior ends of the mandibles, detaching them from the substratum and
      allowing their ingestion by ciliary action. The first pair of maxillae are also
      capable of independent action and can be used while the remainder of the
      proboscis apparatus is held in the protracted position. 6. Detached
      microorganisms are entangled in a sticky mucous secretion from the salivary
      glands; other salivary secretions provide a transport medium for the clumped
      particles and a third set contain C-esterases which initiate digestion. 7.
      Ingested food is held briefly in the proventriculus, then passed to the stomach
      where gland cells secrete A- and C-esterases which continue and extend the
      digestion initiated by the salivary C-esterases. 8. Some soluble products of
      gastric digestion are taken up by absorptive cells in the stomach wall and their
      digestion is completed intracellularly by enzymes which include  beta
      glucuronidase. Others pass into the intestine for absorption and completion of
      digestion by cells similar to the gastric absorptive cells but which lack beta
      glucuronidase...

PMID- 1016664
TI  - Thermal compensation in protein and RNA synthesis during the intermolt cycle of
      the American lobster, Homarus americanus.
AB  - 1. The in vitro rates of incorporation of precursors into protein and RNA and the
      concentration of RNA were measured in tissues of intermolt and premolt lobsters
      acclimated to 5 degrees C and 20 degrees C. Midgut gland, abdominal muscle and
      gill of intermolt lobsters respond to temperature acclimation by a compensatory
      translation of the rate-temperature (R-T) curves with respect to the rates of
      incorporation of 3H-leucine and 3H-uridine into the acid-insoluble fraction.
      Midgut gland and muscle of premolt animals exhibit either no compensation or
      inverse compensation; gill tissue exhibits a rotation of the R-T curve. 2. The
      existence of the complete de novo pathway of pyrimidine biosynthesis is
      demonstrated in the class Crustacea. NaH14 CO2 is incorporated into orotic acid
      and orotic-14 C-acid is incorporated into the acid-insoluble fraction. 3. Both
      the concentration of RNA and the rates of incorporation of precursors of both the
      salvage and de novo pyrimidine pathways are enhanced in the midgut gland of
      premolt lobsters, relative to intermolt tissue, under conditions of warm
      acclimation.

PMID- 1016665
TI  - Morphological adaptation to thermal stress in a marine fish, Fundulus
      heteroclitus.
AB  - Populations of Fundulus heteroclitus (Cyprinodontidae), a coastal marine fish,
      were studied in control and artificially heated environments on the north shore
      of Long Island to determine patterns of variation in morphology and the extent to
      which this variation reflected adaptation to environmental characteristics.
      Principal components and discriminant function analyses were used to analyze
      variation in and among seventeen morphological characters. Fishes living in water
      artificially heated by a power plant exhibited marked divergence from control
      populations in head morphology, and convergence with a population sampled at more
      southern latitudes. Hence, these differences were interpreted as adaptations to
      warm environments. Greater morphological variation is detected at the heated
      locality than at control localities, and this may be partially due to a breakdown
      in developmental homeostasis, and partially due to selection favoring phenotypes
      that are rare in this environment.

PMID- 1016666
TI  - Development and metamorphosis of the sea-star, Astropecten scoparius
      Valenciennes.
AB  - 1. Astropecten scoparius develops to a bipinnaria with simple ciliary bands and
      short bipinnari arms through a wrinkled blastula by holoblastic, radial cleavage.
      2. About seven days after insemination, the posterior portion of the bipinnaria
      becomes swollen and fine spicules appear on it, while the anterior portion, the
      stalk, remains unchanged. 3. Metamorphosis takes place gradually at the posterior
      portion, while the metamorphosing bipinnaria is pelagic. Two weeks after
      insemination, the stalk rapidly shrinks and the larva sinks to the bottom. 4.
      About 18 days after insemination, the juvenile completes metamorphois with the
      opening of the mouth. The newly metamorphosed juvenile is 600 mu in diameter and
      each arm bears two pairs of the tube-feet, each having a sucker at the tip, and
      one terminal tentacle with red eye-spot. 5. The aboral skeletal system of the
      juvenile immediately after metamorphosis is composed of one central, one
      madreporic, ten radial and interradial plates, in addition to five terminal
      plates on the arms. 6. The juveniles smaller than about one cm in R do not bear
      some of the diagnostic features in this species. 7. A characteristic feature of
      the development of Astropecten, i.e., the lack of a brachiolaria stage, is
      stressed. The term "nonbrachiolarian type" is tentatively proposed to distinguish
      the development of Astropecten and Luidia, which do not pass through a
      brachiolaria stage, from the usual indirect type of development.

PMID- 1016667
TI  - Symbiotic association of Photobacterium fischeri with the marine luminous fish
      Monocentris japonica; a model of symbiosis based on bacterial studies.
AB  - Isolation of bacteria from the luminous organ of the fish Monocentris japonica
      has revealed that the organ contains a pure culture of luminous bacteria. For the
      four fish examined, all contained Photobacterium  fischeri as their luminous
      bacterial symbiont. This is the first time that P. fischeri has been identified
      in a symbiotic association. A representative isolate (MJl) of the light organ
      population was selected for in vivo studies of its luminous system. Several
      physiological features suggest adaptation for symbiotic existence. First, MJl has
      been shown to produce and respond to an inducer of luciferase that could
      accumulate in the light organ. Secondly, the specific activity of light
      production was seen to be maximal under low, growth-limiting concentrations of
      oxygen. Thirdly, unlike another luminous species (Beneckea harveyi), synthesis of
      the light production system of these bacteria is not catabolite repressed by
      glucose--a possible source of nutrition in the light organ. Fourthly, when grown
      aerobically on glucose these bacteria excrete pyruvic acid into the medium. This
      production of pyruvate is a major process, accounting for 30-40% of the glucose
      utilized and may serve as a form of regulatory and nutritional communication with
      the host.

PMID- 1016668
TI  - Exchanges of sodium and chloride at low salinities by Nereis diversicolor
      (Annelida, Polychaeta).
AB  - 1. Experiments to compare the exchange (total influx) of sodium and chloride in
      the polychaete Nereis diversicolor in steady-state adaptation to very low
      salinities are reported. 2. The Na-uptake mechanism shows a high affinity for
      sodium, reaching half the maximal uptake rate at an external Na-concentration of
      8-10 mM/liter (ca. 2% SW), and becomes "saturated" or reaches a plateau of uptake
      at concentrations of 40-50 mM/liter (ca. 10% SW) up to ca. 350 mM/liter (75% SW),
      above which Na-exchange is proportional to the external concentration. 3. The Cl
      uptake curve differs from the Na-uptake curve in showing a relative depression at
      very low salinities before reaching "saturation" at Cl-concentrations of 50-60
      mM/liter (ca. 10% SW). Cl-uptake becomes proportional to external concentration
      in salinities of 50% SW or greater, suggestive of passive diffusion in the ionic
      and osmotic conforming range. 4. It is shown that the permeability of the body
      wall, both to Na and to Cl, is reduced at very low salinities, thus destroying
      one of the assumptions upon which a previously-presented balance-sheet for
      chloride exchanges in N. diversicolor was based (Smith, 1970a). 5. Attempts to
      demonstrate an activation of the Na-uptake mechanism at very low salinities were
      inconclusive; reduction of body-wall permeability to sodium masks any possible
      activation. 6. It is suggested that the inside-negative body-wall potential is
      related to the depression of the Cl-uptake curve in salinities below 10% SW.

PMID- 1016669
TI  - Osmotic adjustment in an estuarine population of Urosalpinx cinerea (Say, 1822)
      (Muricidae, Gastropoda).
AB  - Individuals from a subtidal, estuarine population of the common oyster drill,
      Urosalpinx cinerea (Say, 1822), were brought into the laboratory and tested for
      osmotic adjustment to changing salinity. Tissue variables monitored at seven
      experimental salinities ranging from 10 to 40% were tissue fluid osmolality,
      chloride, sodium, potassium, free amino acids (FAA), ninhydrin-positive
      substances (NPS) and water content. The results of this study demonstrate that
      the test animals did not exhibit anisosmotic regulation at any of the
      experimental salinities. However, the data do suggest a high degree of hyper
      ionic regulation of potassium at all experimental salinities and a hyporegulation
      of sodium between the 25 and 40% salinities. Taurine, aspartic acid, alanine and
      glycine were the four FAA present in relatively consistent high amounts. These
      four amino acids comprised from 59.6 to 75.7% of the total FAA pools. It is
      postulated that the population does not maintain its euryhaline survival status
      through an osmoregulatory mechanism. Rather, the population has probably adapted
      physiologically to withstand dilution of its body fluids during spring conditions
      of low salinities.

PMID- 1016670
TI  - [Use of French as language for scientific publication. Warning of the "paper
      drain"].

PMID- 1016671
TI  - [Transplantable lines and cell cultures obtained from intestinal carcinomas
      chemically induced in rat (author's transl)].

PMID- 1016672
TI  - [Quantitative study on the influence of different alkaline agents on the
      experimental ulcerogenic and analgesic activity of aspirin (author's transl)].

PMID- 1016673
TI  - [Fate of tritiated gastrin (3HGI) in the rat after total gastrectomy and after
      antrum transposition to colon (author's transl)].

PMID- 1016674
TI  - Mucus depletion, plasma protein leakage and latent or gross bleeding from gastric
      mucosa, following extragastric war wounds in Vietnam.

PMID- 1016675
TI  - [The acid concentration of the parietal component of the gastric juice in normal
      individuals and in patients with gastroduodenal disease (author's transl)].

PMID- 1016676
TI  - [Radioimmunoassays of CEA and an alpha-1-acid glycoprotein in gastric juice.
      Respective interest in the detection of gastric cancer (author's transl)].

PMID- 1016677
TI  - A method of measuring the temporal/distance factors of gait.
AB  - There exist many clinical situations where it is desirable to have some measure
      of a patient's ability to walk. The complex nature of human locomotion is
      reflected by the number of parameters that have been measured in previous studies
      of gait analysis. The temporal/distance factors of gait have been found to be
      extremely useful as a measure of a person's functional mobility. This paper
      describes a system which has been developed to measure these parameters of gait.

PMID- 1016678
TI  - A solid state delayed auditory feedback system for speech therapy.
AB  - A delayed auditory feedback system has been constructed using solid state
      integrated circuit components. The construction of the instrument is described
      and the advantages of such an electronic device over conventional electro
      mechanical systems are discussed.

PMID- 1016679
TI  - Elevated myo-inositol concentrations in cerebrospinal fluid of neonates and of
      patients with an impaired state of consciousness.
AB  - A simple, semiquantitative paper chromatographic method was used to identify
      samples of cerebrospinal fluid containing elevated concentrations of myo
      inositol. All patients whose CSF inositol concentrations were greater than 70
      mug/ml (as determined by S. carlsbergensis microbiological assay) showed
      disturbances of the state of consciousness, reported as stupor, coma or confusion
      in adults, or apathy and stupor in infants. An elevated level of inositol in
      cerebrospinal fluid appeared to be a characteristic finding in infants under one
      year of age. Among other age groups no common etiology was correlated with high
      inositol concentration.

PMID- 1016680
TI  - Inhibition of free fatty acid release from isolated rat epididymal fat cells by
      some natural occurring organic acids.
AB  - The effects of some mono-, di- and tricarboxylic substrates (acetate, pyruvate, L
      lactate, L-alanine, D,L-beta-hydroxybutyrate, succinate, D,L-malate, alpha
      oxoglutarate, L-glutamate and citrate) on the basal lypolytic activity of
      isolated white adipocytes from fasted rats were investigated "in vitro". At
      concentrations ranging from 1 to 10 mM, the compounds tested, except lactate, had
      no influence on the rate of glycerol release but markedly reduced the free fatty
      acid (FFA) release. Lactate reduced both the glycerol and FFA release. As this
      "in vitro" lowering effect on FFA release was observed using concentrations
      occurring "in vivo" in the blood for lactate, beta-hydrobutyrate, and alanine,
      these results suggest that, besides lactate and beta-hydroxybutyrate, alanine may
      also assume an important role in the "in vivo" regulation of peripheral FFA
      mobilization and consequently of ketogenesis.

PMID- 1016681
TI  - Enhancement of murine erythrocyte auto-antibody responses by Rauscher
      leukemogenic virus and by a weak allogeneic stimulation.
AB  - B6/c mice do not develop spontaneous positive direct Coomb's tests (DCT), but
      they are highly susceptible to the induction of erythrocyte auto-antibodies by
      immunization with cross reacting rat blood cells (36% positive DCT). Rauscher
      leukemogenic virus (RLV) does not directly induce DCT in these susceptible mice;
      neither does the inoculation of parental spleen cells. On the other hand both RLV
      and allogeneic stimulation by parental spleen cells enhance the incidence of the
      rat blood cell-induced DCT (up to 75% and 69% respectively). This is discussed in
      terms of a separate etiology to antinuclear and anti-erythrocyte auto-antibodies
      and of the possible mechanisms of auto-immune stimulation by oncogenic viruses or
      allogeneic stimulation.

PMID- 1016682
TI  - Fluorescence and flow dichroism of F-actin-epsilon-ADP; the orientation of the
      admine plane relative to the long axis of F-actin.
AB  - The excitation polarization spectrum of epsilon-ADP bound to F-actin shows that
      two absorption dipoles at 260 nm and 340 nm are oriented in different directions
      relative to the emission dipole. On the other hand, the linear dichroism of F
      actin-epsilon-ADP gives that the dichroic ratio of the bound epsilon-ADP is
      approximately constant (about-0.5) in the wavelength region form 250 to 350nm.
      Furthermore, the fluorescence polarization of epsilon-ADP bound to F-actin which
      is oriented in the field of flow shows that the emission dipole is nearly
      perpendicular to the long axis of F-actin. From these observations we conclude
      that the adenine plane of the bound nucleotide is almost perpendicular to the
      long axis of F-actin.

PMID- 1016683
TI  - Optical studies on complexes between DNA and pseudoisocyanine.
AB  - Linear dichroism (LD) results when pseudoisocyanine=PIC (1,1-diethy1-2,2-cyannine
      iodide) binds to flow-oriented DNA. LD may be used to follow the complexation
      both stoichmetrically and structurally, since when specified to unti complex
      concentration LD provides a measure of the average orientation of the absorbing
      transition dipole. Two different types of complexes can be distinguished: I. One
      strong, ionic-strength insensitive complex with monomeric PIC with an orientation
      indication intercalation. II. Several weaker complexes of electrostatic nature
      (only observed at I less than 0.2M Na Cl) among which those with dimeric (IIa)
      and with polymeric (IIb) PIC are concluded both from LD and from circular
      dichroism (CD). The dimer is probably formed by employing one intercalated PIC as
      a second site. The polymer complex is characterized by a very sharp absorption
      band at 553 nm polarized parallel to the DNA-axis (with positive LD and positive
      CL). The structure, a right-handed helical array of PIC molecules, is discussed
      in terms of exciton theory in relation to that of polymeric free PIC ("Scheibe
      polymer") which is also shown to interact with DNA (IIc) yielding a large
      aggregate which is degraded at a distinct flow force field...

PMID- 1016684
TI  - Model calculations of casein micelle size distributions.
AB  - A previously proposed model for the formation and structure of casein micelles
      from subunits of variable composition is used to calculate theoretical micelle
      size distributions. Using the fractional content of k-casein as the only variable
      but with a value near that observed in a sample of milk serum, the model
      successfully reproduces experimentally determined distributions. Predicted size
      distributions are quite sensitive to the value of the variable and shift toward
      smaller average size as the assumed fractional content k-casein gets larger.
      Also, there is a discontinuity in the distributions which predicts that there
      will be essentially no micelles with radii smaller than 25-30 nm. These
      predictions are all in accord with experimental observations. The good agreement
      between theory and experimenet supports the micelle structure suggested by the
      model.

PMID- 1016685
TI  - On the analysis of linear binding effects associated with curved Scatchard plots.
AB  - First the question is examined as to which binding data, especially if given as
      Scatchard plots, can be described in terms of a basic model mechanism. This
      referes to a linear lattice of equivalent binding sites (as for example located
      on a linear biopolymer) which can exert cooperative interaction between nearest
      neighbors. It is shown that the effect of overlapping of potential site (so
      called "multiple-contact"binding), as may occur with larger ligands, will largely
      be compensated by a higher degree of cooperativity. Therefore, in practice such
      properties can scarcely be separated by means of oridnary binding experiments. A
      pronounced inflection point in the Scatchard plot turns out to be clearly
      indicating a more complex mechanism involving at least two rather antagonistic
      cooperative interactions which may, however, occur even between equivalent
      binding sites. Finally some consequences of different classes of bindings sites
      are considered. In particular a simple approach is introduced by which the
      binding to mutually exclusive classes of sites may be described. Such a model is
      of interest for multiple-mode binding of ionic ligands to oppositely charged
      polymers.

PMID- 1016686
TI  - Aggregation of chlorophylls in monolayers.
AB  - The interaction of dioxane vapor with monolayer and multilayers of chlorophyll
      has been studied using electronic and infarared spectroscopies. Our results
      indicate the formation of a complex implying the oxygene of the dioxanc molecules
      with the magnesiums of adjacent chlorophyll molecules. These results are
      consistent with the molecular orbital calculations, using the "free electron
      network" method done by Le Brech, Leblanc and Antippa [Chem. Phys. Letters
      26(1974) 37-44].

PMID- 1016687
TI  - High pressure enzyme kinetics of dextransucrase.
AB  - The pressure dependence of enzymatic dextran formation has been observed up to
      1000 at for several substrate concentrations. First order denaturation effects
      could be separated from the thermodynamic effects, which lead to a volume of 30.4
      to 44.0 ccm per mole for the formation and -13.6ccm per mole for the activation
      of the enzyme-substrate complex. Denaturation depends on the substrate
      concentration. This leads to the conslusion that only the free enzyme is
      denatured, wheras the ES complex is stable.

PMID- 1016688
TI  - Thermodynamic properties of polyelectrolyte solutions containing mixtures of
      monovalent and trivalent counterions.
AB  - The osmotic coefficients, heats of dilution, and volume changes on dilution of
      aqueous solutions containing mixtures of polystyrenesulfonic acid and its
      lanthanum salt have been determined at 25 degrees C. The curve representing the
      osmotic coefficient as a function of the equivalent fraction of the acid has a
      maximum; the corresponding curves for the enthalpy and volume changes on dilution
      have a sigmoidal shape. Experimental results have been compared with predictions
      of the theory based on the cell model with cylindrical symmetry. A
      semiquantitative agreement between theory and experiment has been found.

PMID- 1016689
TI  - Investigation of the electronic term scheme of deoxygenated human haemoglobin by
      a least squares fit procedure using simultaneously magnetic susceptibility and
      Mossbauer data.
AB  - The calculation of the magnetic susceptibility from a published term scheme for
      the ferrous iron in deoxygenated human haemoglobin is discussed and a procedure
      for the simultaneous least squares fit of susceptibility and Mossbauer data is
      presented. The application of this procedure to the appropriate measurements on
      human haemoglobin leads to a rearrangement of the low lying electronic levels of
      the iron. The term schemes received as results of two different sets of
      susceptibility data used in combination with one set of Mossbauer data overlap
      with their error bars. The obtained level scheme of the Fe is correlated with the
      distance of the iron atom from the haem plane and the distance Fe-HIS F8, and
      some biological implications of these correlations are discussed.

PMID- 1016690
TI  - The problem of nonstationary ion fluxes in excitable membranes.
AB  - Time-dependent electrodiffusion through a membrane is analysed within a simple
      model treating the boundary-layers in a consistent manner. It is shown that time
      independent reversal potentials for the ion fluxes exist only under steady-state
      conditions. We argue that this result holds very generally. Therefore
      nonstationary effect like ion storage and depletion inside the membrane should
      not contribute to the phenomena of excitability.

PMID- 1016691
TI  - Theory of fluorescence polarization of oriented pigment molecules in spherical
      arrays.
AB  - Theoretical results are presented which are appropriate for the analysis of the
      static polarized fluorescence experiment with oriented pigment molecules in
      spherical arrays (vesicles). Though the global orientation mediated over the
      whole sphere is isotropic, the fluorescent molecules may have preferred local
      orientation with respect to the local plane. As in a former paper, concerning
      fluroescence polarization in planar arrays, three basic (local) orientation
      distributions of the electronic transition moments are investigated, which may be
      expected to describe a wide class of real cases with sufficient accuracy.
      Analytic expressions for the degree of polarization are derived. One important
      result is that the degree of polarization may be extremely dependent on the local
      orientation of transition moments. Hence the usual method of determination of
      microviscosities from experiments with vesicles with the use of the theory of
      fluorescence polarization for macromolecules in solutions should be regarded with
      great caution.

PMID- 1016692
TI  - Orientation and rotational freedom of fluorescent probes in lecithin bilayers.
AB  - The fluorescence polarization properties of lecithin bilayers stained with 2,6
      MANS and 1,8 ANS under applied potential steps have been studied. The
      fluorescence signal components of both dyes were found to have different sign and
      relative amplitude, suggesting that 1,8-ANS and 2,6-MANS behave differently when
      bound to black lipid membranes. In order to determine the location and the extent
      of rotational brownian motions of the bound chromophores, the experimental data
      were analyzed by using a simplified physico-mathematical model. According to it
      2,6-MANS appears to have a ratio rho/tau higher than 1.8-ANS (rho being the
      rotational relaxation of in plane rotations and tau the lifetime of the excited
      singlet state of the bound molecules), suggesting that the former chromophore is
      more tightly held inside the bilayers. Furthermore, 2,6-MANS is found to possess
      the absorption and emission oscillators more closely oriented to the normal of
      membrane surface, while 1,8-ANS has both oscillators almost near the plane of the
      bilayers. The results furnish also a fair estimate of the random molecular motion
      own by the phospholipid molecules at room temperature. The comparison of the
      present data with those obtained from squid axon membranes confirms the validity
      of the proposed physical model, yielding a rough estimate of the axon membrane
      area covered by integral protein macromolecules. These preliminary results
      derived from lecithin model membranes suggest that fluorescence polarization
      techniques can provide valuable informations if applied to study the
      macromolecular organization of in vitro reconstituted membranes.

PMID- 1016693
TI  - Kinetic isotope effects in the photochemical cycle of bacteriorhodopsin.
AB  - Kinetics were determined for the four transients K590, L540, M410, O660 of the
      photochemical cycle of bacteriorhodopsin (BR570) both in 1H2O and in 2H2O over a
      wide temperature range. Breaks in the Arrhenius plots, observed at 25 degrees-32
      degrees for the longest-lived transients coincide with a transition point in the
      microviscosity of the membrane as measured by depolarization of an added
      fluorescent probe. The earliest isotope effect occurs in the decay of L540, and
      is present in the subsequent formation and decay of M410 and O660. Thus in the
      light-driven proton pump of BR570, proton ejection from the Schiff base
      correlates with decay of L540 and reprotonation occurs with the decay of both
      M410 and O660 back to BR570.

PMID- 1016694
TI  - Facilitated diffusion of amino acids across bimolecular lipid membranes as a
      model for selective accumulation of amino acids in a primordial protocell.

PMID- 1016695
TI  - Complementary molecular models of learning and memory.
AB  - The functional capabilities of the brain are formally characterizable interms of
      a finite system along with a memory space which it can manipulate. Two types of
      learning are possible: (1) modification-based learning, associated with alternate
      realizations of the finite system; (2) memory-based learning, associated with the
      assimilation, manipulation, and retrieval of memories. Constructive models which
      fulfill these conditions and which at the same time operate on the basis of
      molecular information processing principles have certain general features. We
      describe these features in terms of two interfaced submodels, the first for the
      finite system and the second for the memory space. The finite system may be
      realized by networks of neurons in which the specificity of enzyme molecules
      controls the nerve impulse. Such a realization is amenable to modification-based
      learning mediated by processes analogous to those of natural evolution and
      selective theories of antibody synthesis. The memory space is realizable by
      networks of neurons in which the conformation of dendritic receptor molecules
      controls the nerve impulse. In this case certain neurons firing in response to an
      external input undergo sensitization at the dendrites and in such a way that they
      are loadable and later callable by reference neurons, thereby allowing for
      reconstruction of manipulation of the firing pattern associated with this input.
      The overall construction makes a large number of biochemical, anatomical,
      physiological, and psychological predictions which are either testable or in good
      agreement with fact.

PMID- 1016696
TI  - The handedness or chirality of biological structure at the molecular and at
      higher levels of structural organisation.

PMID- 1016697
TI  - Abiotic synthesis of some polysaccharide-like and polypeptide-like structures in
      cold plasma.
AB  - Starting from methane, ammonia and water vapors polypeptide-like and
      polysaccharide-like structures have been synthesized in cold plasma conditions.
      By gel filtration analysis of the raw product eight fractions of different
      molecular weight have been separated. The partial chemical nature of each
      fraction and of the hydrolysis products has been determined using elementary
      analysis, IR spectroscopy, paper, thin-layer and gas-chromatography. It is
      noteworthy that higher proportions of H2O in the feed composition increase the
      amount of sugar and polysaccharide-like compounds in the reaction product.

PMID- 1016698
TI  - [Mechanism of the fast neurogenic component of the respiratory response to
      muscular work].
AB  - Dynamics of pulmonary ventilation, electric activity of the intercostal muscles
      and of the alveolar gas composition was studied in 12 healthy men during dosaged
      muscular work; these men were given different gas mixtures to breathe. The
      respiratory response at the initial period of work in inhalation of the hypoxic
      hypercapnic gas mixture was greater than that in persons who breathed room air.
      This response practically disappeared after oxygen hyperventilation. Apparently
      the rapid component of the ventilation response to the muscular work was largely
      due to increased sensitivity of the respiratory centre to the chemoreceptive
      drive.

PMID- 1016699
TI  - [Changes in the cerebral serotonin and noradrenaline levels in the brains of
      white rats trained with emotionally different reinforcement].
AB  - The changes in the serotonin (5-OT) and noradrenaline (NA) content in the brain
      of rats taught on the emotionally-positive (food) and emotionally-negative (pain)
      reinforcement were compared. The process of animal learning was accompanied by
      increase in the biogenic amine level. But when the teaching was conducted on the
      emotionally-positive reinforcement there was a greater increase in the 5-OT and
      NA level than in the case of the emotionally negative reinforcement. The process
      of animal teaching on food reinforcement was accompanied by an elevation of 5-OT
      chiefly in the cerebral cortex which apparently reflected the active functioning
      of the 5-OT system. An intensification of the NA system occurred in teaching the
      animals in the defence situation. A conclusion was thus drawn that the character
      of the changes in the biogenic amine level in the brain during learning depended
      on the emotions experienced by the animal (the emotional reinforcement utilized).

PMID- 1016700
TI  - [Effect of copper, manganese and cobalt ions on the chemical sensitivity of
      interoceptors].
AB  - Acute experiments were conducted on 82 cats; a study was made of the influence of
      copper, manganese and cobalt on the chemical sensitivity of interoceptors.
      Administration of copper chloride caused inversion of the reflex reactions of the
      blood pressure and respiration to acetylcholine, cobalt chloride weakened these
      reactions, and manganese chloride intensified them. It is supposed that changes
      in the interoceptive reflexes observed depended chiefly on the direct action of
      microelements on the functional condition of the interoceptors.

PMID- 1016701
TI  - [Functional state of the left ventricle of the heart in cardiocytotoxic shock].
AB  - Changes in the cardiodynamics and the contractile myocardium function under
      experimental shock caused by intracoronary injection of the anticardial cytotoxic
      serum were studied on 20 anesthetized dogs. Along with the symptoms of
      disturbance of the left ventricle function (a decrease of the systolic index,
      stroke work index of the left ventricle, rate of the intraventricular pressure
      rise, indices of myocardial contractility, ejection fraction) a decrease of the
      end-diastolic volume and pressure in the left ventricle was observed. These data
      show that disturbances in the cardiodynamics were cause not only by the cytotoxic
      heart damage, but also by derangement of the blood flow to the left heart.

PMID- 1016702
TI  - [Effect of different types of excessive feeding on the state of vascular walls in
      rats].
AB  - Immature male rats were overfed for a long time with an excess of fats or
      carbohydrates; this caused obesity. Carbohydrate overfeeding led to a greater
      body weight gain and a greater increase in the weight of epididymal fat and of
      the adipose cell volume than fat overfeeding, but failed to decrease the
      lipolytic activity of the aorta. Prolonged fat overfeeding decreased the
      lipolytic activity of the aorta considerably. Thus, the results of the mentioned
      experiments showed that the predisposition of the aortic wall to atherogenesis
      did not correlate with the gain in weight and depended on the character of
      nutrition.

PMID- 1016703
TI  - [Erythropoietic activity of human blood following exposure to hyperbaric
      hyperoxygenation].
AB  - Before exposure of man to hyperoxia the blood plasma posessed erythropoietic
      activity, but 18 to 20 hours after exposure to compressed air condition in the
      high pressure chamber corresponding to the depth of 100 metres there proved to be
      a marked fall of the erythropoietic activity. No statistically significant shifts
      were revealed in the peripheral blood indices by that time.

PMID- 1016704
TI  - [Interrelationship between the structure, microcirculation and tissue-vascular
      permeability of the liver after experimental toxic damage].
AB  - Biomicroscopic and morphological studies demonstrated that in experimental
      heliotrine affection  of the liver there occurred very early and marked
      microcirculatory disturbances which preceded the parenchymal damage. With the
      further progress of the pathomorphological changes and chronization of the
      pathological process in the liver one of the leading roles was played by the
      advance of microcirculatory disturbances and of the tissue-vascular permeability
      leading to hypoxia of the hepatic tissue and derangement of the metabolic
      processes in the organ.

PMID- 1016705
TI  - [Role of the kidneys in the mechanism of erythrodieresis in hemolytic
      (phenylhydrazine) and acute posthemorrhagic anemia].
AB  - The degree of hemolysis was studied comparatively in intact and nephrectomized
      rats after the phenylhydrazine injection. In the nephrectomized animals hemolytic
      (phenylhydrazine) anemia was expressed by a lesser reduction of the total
      erythrocyte count, of the percentage of Cr51-labeled erythrocytes, and of the
      intensity of the reaction for hemosiderin in the organs and tissues. A lesser
      degree of erythrodieresis was found in the nephrectomized rats and after an acute
      unsubstituted blood loss. Blood perfusion through the kidney of anemic rats led
      to increase of the potassium concentration in the plasma perfusate, reduction of
      the electrophoretic mobility of erythrocytes, their resistance, hemolysis
      duration, and to decrease of albumin fractions with the mol wt of from 74 500 to
      27 000 in the erythrocyte stroma.

PMID- 1016706
TI  - [Functional state of the hypothalamo-hypophyseo-adrenal system of guinea pigs
      under the influence of angular acceleration].
AB  - Experiments were conducted on guinea pigs. A study was made of the influence of
      increased gravitation on the activity of the hypothalamo-hypophysio-adrenal
      system. It appeared that a single centrifugation led to the activation of the
      mentioned system; however, repeated action of the angular accelerations on the
      animal organism failed to lead to any increase in the blood corticosteroid level
      (on the 6th-11th days); this can be attributed to the adaptation of the central
      link of the hypophysio-adrenal system to the given stimulus, and not to the
      exhaustion of the adrenal cortex.

PMID- 1016707
TI  - [Effect of cytostatic drugs on fever development following administration of
      bacterial pyrogen].
AB  - A study was made of the development of pyretic reaction to the administration of
      a bacterial lipopolysaccharide (pyrogenal) after preliminary treatment of rabbits
      with actinomycin D and cortisone. Such treatment failed to change the reactivity
      of thermoregulating centres to the endogenous pyrogen. Intravenous injection of
      bacterial pyrogen was followed by marked shortening of pyretic reaction; the
      reaction was markedly inhibited in response to its intracysternal administration.
      An important role played by polymorphonuclear leukocytes in the formation of
      endogenous pyrogens in the mechanism of pyrexia induced by bacterial pyrogens was
      shown in this work.

PMID- 1016708
TI  - [Changes in the activity of 3beta-OH-steroid dehydrogenase in the adrenals of rat
      fetuses following decapitation in utero].
AB  - The activity of 3beta-OH-steroid dehydrogenase in the adrenal cortex of 21-day
      fetuses in control and 3 days after decapitation in utero was estimated
      quantitatively by microspectrophotometry. The enzyme activity calculated as per
      conditioned cell in the fascicular zone exceeded that in the forming glomerular
      zone. After hypophysectomy the activity of the 3beta-OH-steroid dehydrogenase
      decreased in both the fascicular and glomerular zones.

PMID- 1016709
TI  - [Effect of insulin on the adipose tissue of patients with diabetes mellitus].
AB  - A study was made of insulin sensitivity of the adipose tissue biopsied in 11
      healthy women, and in 10 women with normal weight suffering from newly-detected
      diabetes mellitus. In difference from healthy persons in the adipose tissue of
      patients suffering from diabetes, insulin in a concentration of 50 mu/ml failed
      to enhance the oxidation of glucose to CO2, and in a concentration of 50 and 100
      mu/ml failed to enhance the glycogen synthesis from glucose. Reduction of the
      sensitivity of different ways of glucose metabolism in the adipose tissue to
      insulin in patients suffering from diabetes mellitus pointed to the possibility
      of disturbance of insulin interaction with the cell membrane in this disease.

PMID- 1016710
TI  - [Heterogeneous hemoglobin system in anemic rats].
AB  - Fractional contents of hemoglobins of the peripheral blood, spleen and the bone
      marrow was studied in intact and anemic rats by using electrophoresis in
      polyacrylamide gel. Anemia was caused by injection of phenylhydrazine (HCl) into
      the animals. The principal regularities in the formation of the heterogeneous
      system of hemoglobin, depending on its source and the animal condition, was
      established. Possible mechanisms responsible for the rebuilding of the fractional
      contents of the protein investigated and its biological sense are discussed.

PMID- 1016711
TI  - [Changes in the intensity of retinal protein synthesis].

PMID- 1016712
TI  - [RNA concentration in neuron-neuroglia systems of the retina and visual zones of
      the cerebral cortex during light deprivation and light stimulation].
AB  - A two-wave-length cytophotometry of the gallocyanin-chromium alum-stained
      preparations showed that in adult rats kept for 30 days in complete darkness
      there was a decrease in the RNA content in the perineuronal neuroglia of the
      retinal ganglion cell layer only, with no changes in the corresponding neurons.
      No changes were found in the neurons and in the perineuronal glia of the layer II
      --III of the visual cerebral cortex. After the end of light deprivation a 2-hour
      stimulation with a constant or flickering light did not influence the RNA content
      in the neurons of both regions of the visual analyzer studied, whereas in control
      rats this stimulation induced a marked increase in the RNA content in these
      neurons. Qualitative changes in the metabolism of the cellular RNA in the nervous
      system of adult animals under the effect of light deprivation are emphasized.
      Differences in the biochemical peculiarities of various neuron-neuroglia systems,
      depending on their localization in the visual analyzer, are discussed.

PMID- 1016713
TI  - [Effect of muscular load on the invertase activity of the small intestine].
AB  - Acute experiments were conducted on male albino rats; a study was made of the
      invertase activity of the proximal, middle and distal portions of the small
      intestine after a 2-, 4- and 10-hour muscular load in the form of swimming in
      water at a temperature of 35 +/- 1 degree C. After 2 hours of swimming the
      invertase activity in the first two portions showed a rather sharp fall; it was
      restored to the initial level in 48--72 hours. This reduction was much less in
      the distal portion. Both the 4- and the 10-hour swimming led to an insignificant
      elevation of the enzymatic activity in all the three portions during 24 hours,
      with a subsequent decrease in the first two portions and a marked elevation in
      the distal portion after 48 hours. It is supposed that these changes were
      realized by means of the hypothalamo-hypophysio-adrenal system by the principle
      of the common nonspecific adaptive syndrome.

PMID- 1016714
TI  - [Structural changes in nucleoprotein systems under the influence of serum from
      ill and healthy subjects].
AB  - A thermomechanical method was applied to the study of the interaction of the
      model desoxyribonucleoprotein systems (DNP-systems) of chromatin with the blood
      sera of healthy and sick persons. It was demonstrated that the blood sera of
      healthy persons caused decondensation of the DNP-systems. The intensity of this
      action varied when the sera with the composition altered as a result of pathology
      were used: the sera of the patients suffering from systemic lupus erythematosus
      increased the condensation; in comparison with the sera of healthy persons, the
      sera of schizophrenic patients intensified the DNP-system decondensation. The
      sera action was not connected with the activity of the serum enzymes. The role
      played by the serum components in regulation of the structural-functional
      chromatin properties is discussed.

PMID- 1016715
TI  - [Isolation of the most active DNA synthesizing cells of hematopoietic organs by
      fractionation on a density gradient of albumin].
AB  - After separation of the bone marrow or the spleen suspension on the discontinuous
      albumin gradient cell fractions were obtained in which the activity of the DNA
      dependent DNA polymerase, aspartate carbamoyl transferase, as well as the rate of
      the 14C-thymidine incorporation in the DNA was 2 to 3 times higher than in the
      original suspension. The most actively DNA-synthesizing cells were concentrated
      in the 5th-6th fractions when the osmolarity of 35% BSA was 370 mOsm, or in the
      2nd-3rd fractions when the osmolarity of 35% BSA was 380 mOsm.

PMID- 1016716
TI  - [Participation of GABA and glycine in the formation of somato-sympathetic
      reflexes].
AB  - Experiments were conducted on cats with intact spinal cord, and after
      spinalization a study was made of the action of strychnine and picrotoxin
      (synaptic GABA and glycine antagonists) on the components of somatosynaptic
      reflexes caused by stimulation of the skin and muscular intercostal afferents.
      Induced potentials were recorded in the white ramus of the third thoracic
      segment. The action of strychnine and picrotoxin on the values of different
      reflex components was not identical; this pointed to a different localization of
      the inhibitory action of GABA and glycine in the central link of the
      somatosympathetic reflex arch.

PMID- 1016717
TI  - [Analysis of the effect of morphine and promedol on uptake and release of
      noradrenaline by myocardial tissue].
AB  - A study was made of the effect of morphine and promedol on the content, uptake,
      and release of norepinephrine (NE) on rat myocardium. Promedol proved to decrease
      the NE level in the myocardium. Morphine failed to influence the release of the
      NE-14C from the isolated perfused heart, whereas promedol increased it
      significantly, altering both the "slow" and the "rapid" release of the mediator.
      Promedol failed to influence the uptake of NE-14C by the perfused heart, whereas
      morphine decreased it significantly. The competition between morphine and NE was
      characterized by the effect of incomplete inhibition: morphine and NE produced
      reciprocal effects on the affinity of one another to the receptor, and their
      interaction depended on the ratio of the concentrations of these drugs.

PMID- 1016718
TI  - [Synchronization of cellular proliferation in mice with sarcoma 37 by using
      hydroxyurea].
AB  - The synchronizing effect of hydroxyurea on the passage of sarcoma 37 cells
      through the stage of the S-phase and mitosis was investigated in albino mice. The
      study was performed with consideration to the circadian variations in the mitotic
      activity and the labelled nuclei indices. The degree of synchronization was
      assessed by the changes in the cell count and the rate of changes in
      synchronicity. The tumour consisted of at least two cell populations in which the
      variations in the number of cells both at the S-period, and, possibly, in mitosis
      were shifted in respect to one another by phase. The rate of artificial cell
      synchronization in the mitosis proved to be much greater than the natural one in
      the tumour undivided into individual populations. However, the number of cells
      subjected to artificial synchronization showed no significant difference not only
      from the cell count in the tumour undivided into individual populations, but also
      from the number of cells synchronized naturally in one of the populations. This
      could be explained by the fact that hydroxyurea acted on one group of cells only
      since variations in the number of DNA-synthesizing cells were shifted in
      individual populations in respect to one another by phase.

PMID- 1016719
TI  - [Inhibiting effect of cholera vibrio neuraminidase in Rauscher mouse leukemia].
AB  - A study was made of the inhibitory effect of neuraminidase of cholera vibrio in
      mouse Rauscher leukemia. It was shown that the processing of cells of the spleen
      of mice suffering from leukemia with neuraminidase (in a dose of 50 units/ml and
      more) significantly inhibited the capacity of these cells to induce leukemia in
      their injection to BALB/c mice. In the mentioned concentration neuraminidase
      injected repeatedly parenterally produced no therapeutic effect in Rauscher
      leukemia.

PMID- 1016720
TI  - [Effect of the enterotropic carcinogen 1,2-dimethylhydrazine on the level of
      biogenic amines in the hypothalamus of rats].
AB  - The hypothalamic levels of noradrenaline (NA), dophamine (DA), serotonine (5-HT),
      5-hydroxyindolacetic acid (5-HIAA) were found to be decreased in male rats 24
      hours after subcutaneous injection of 1,2-dimethylhydrazine (SDMH) in a dose of
      21 mg/kg. During 3 to 12 hrs after the SDMH treatment the hypothalamic level of
      NA was decreased, whereas the 5-HT turnover became greater. The hypothalamic
      histamine level increased 30 min after the SDMH injection only. In the brain stem
      and the great hemispheres the biogenic amine level displayed no significant
      changes under the effect of SDMH. The endocrine-metabolic changes due to the
      selected SDMH effect on the hypothalamic biogenic amine level are supposed to be
      of great significance in the realization of the carcinogenic action of SDMH in
      rats.

PMID- 1016721
TI  - [Possibility of migration of several elements in biological systems following x
      irradiation].
AB  - The effect of local X-irradiation on the content of trace elements of subcellular
      fractions (nuclear, mitochondrial) and the blood serum of rats with sarcoma M-1
      was studied. It was shown that systematic local irradiation of sarcoma M-1
      (single dose--250 R) during the tumour growth promoted zinc redistribution from
      the nuclei into the mitochondria. In addition, there were revealed statistically
      significant postirradiation changes in the blood serum Ca content of rats with
      sarcoma M-1 after one-time local irradiation of the tumour with 1000 R.

PMID- 1016722
TI  - [Comparative study of the level of mitotic activity and duration of mitosis over
      a 24 hour period in mouse tumors and normal tissue].
AB  - Circadian rhythm of cell division in the forestomack epithelium proved to be
      largely similar to that in the transplantable (continuous) carcinoma of the
      forestomack; the duration of mitosis in these tissues changed in the course of 24
      hours. The mean 24-hour mitotic activity in the tumour was double that in the
      forestomack contrary to this, colchamine (colcemide) accumulated in the course of
      the 24-hours 121.1% mitoses in the forestomack and 83.8% mitoses in the
      carcinoma. A greater number of mitoses in the tumour with the usual count is
      attributed to the fact that the mean 24-hour duration of mitosis of the remen
      carcinoma was 2.7 greater than in the epithelium of the forestomack.

PMID- 1016723
TI  - [Mitotic activity changes in the corneal epithelium of rats of different ages
      following exposure to pain].
AB  - A study was made of pain stimulus (amputation of 1/3 of the tail) on the mitotic
      activity in the corneal epithelium of 21-day fetuses, 1-, 3-, 4-, 5-, 7-, 10-, 15
      , 20- and 25-day rats. In 45 minutes after the infliction of trauma no
      significant change was seen in the cornea of the fetuses and of the one-day-old
      ratlings. A gradual establishment of the reactive inhibition of mitoses in
      response to pain occurred between the 3rd and the 10th day of postnatal
      development. This reaction became more intense after the 10th day, reaching the
      maximum by the 25th day. Reactive inhibition of the mitotic activity was
      connected with the inhibition of the entrance of cells into mitosis.

PMID- 1016724
TI  - [Diurnal changes in the number of mitoses and cells synthesizing DNA in the
      tissues of young rats].
AB  - Regular circadian variations in the mitotic index and in the number of cells
      synthesizing DNA (labelled nuclei index) were shown in the liver, epidermis, and
      in the exocrine portion of the pancreas in 7-day-old rats. The nature of these
      changes differed in the tissues under study. No regular correlations between the
      carcadian variations in these two indices were revealed.

PMID- 1016725
TI  - [Changes in the mitotic activity of the corneal epithelium of white rats
      following coolong of the animals at different times of the day].
AB  - A study was made of the influence of moderate hypothermia on the mitotic activity
      of albino rat corneal epithelium. The animals were cooled by the contact method
      for one hour to 28 degrees C; such procedure was conducted at 6 a.m., at noon,
      and at 6 p.m.; the epithelial reaction to cooling proved to depend on the time,
      the greatest suppression of mitotic activity (14-fold) occurring at daytime 3
      hours after the cooling. A tendency to normalization of cell division was
      observed 6 and 12 hours after the cooling. The number of mitoses decreased 3
      hours after the evening cooling, no changes in the mitotic activity in 3 and 6
      hours after the morning cooling; cell division was found to be suppressed in 12
      hours.

PMID- 1016726
TI  - [Effect of spleen and bone marrow regeneration on the number of hematopoietic
      colonies in mouse spleen].
AB  - The spleen (2/3) was removed in CBA male mice (the 1st group); in the 2nd group
      the bone marrow from the right posterior shin was removed. The hemopoietic
      splenic colonies were counted on the 8th day after the lethal irradiation and
      injection of 1 X 10(-6) nucleated cells of the intact spleen. A significant
      increase of the number of colonies in comparison with their number in control
      intact mice was observed. The authors suppose that this increase could also be
      caused by the local influence of the regenerating stroma of the spleen and by
      some stimulating factor discharge by the regenerating hemopoietic tissue.

PMID- 1016727
TI  - [Recovery processes in the muscles of dogs following free transplantation under
      auto- and homoplastic conditions].
AB  - Whole gastrocnemius muscles, preliminarily (one month before) denervated, were
      auto- and homotransplanted in dogs. The transplanted muscles took at the site of
      transplantation; some of the transplanted material was lost and was resorbed;
      myoblasts were released from the viable disintegrating material. The muscle organ
      was built anew as a result of further differentiation of myogenic elements in the
      autotransplants under conditions of timely restoration of the circulation and
      innervation. No stable take of the transplant occurred in the case of homoplasty-
      the newlyformed muscle was lost as a result of the incompatibility reaction.
      Thus, preliminary denervation serves as an effective means of preparation of the
      muscle tissue for the autotransplantation.

PMID- 1016728
TI  - [Cytologic changes in the myocardia of rats trained to altitude hypoxia].
AB  - Rats trained to the high-altitude hypoxia displayed signs of intensification of
      both the plastic and lytic processes; one of these processes prevailed in
      different cells. There was no significant change in the mitochondrial and
      myofibrillar ratio. An increase of the relative volume of the microcirculatory
      bed on account of dilatation of small vessels without any increase of their count
      was noted.

PMID- 1016729
TI  - [Effect of sympathomimetic substances and DOPA on the ultrastructure of the
      nervous apparatus of the heart].
AB  - After a single administration of norepinephrine or DOPA to albino rats there
      occurred an incorporation of norepinephrine into the adrenergic axons of the
      heart and its deposition in the form of granules in small synaptic vesicles,
      about 300 A in diameter. The adrenergic and cholinergic axons can be thus
      differentiated. The amount of cholinergic axons in the auricles is greater than
      that of the adrenergic ones. The adrenergic terminals came into the most intimate
      contact with the cholinergic terminals and with the endothelial cells of the
      blood capillaries and the myocardial muscle cells. It is supposed that adrenergic
      fibers can act upon the heart muscle in three ways: by means of presynaptic
      inhibition through the cholinergic axons, by humoral route, and directly on the
      myocardial muscle cells.

PMID- 1016730
TI  - [Electron-microscopic study of satellite cell formation in skeletal muscle under
      conditions of physical loading].
AB  - An increase of condensed chromatin was found in the nuclei of the muscle fibers
      of rat skeletal muscle after secondary exhastive physical exercises. Some nuclei
      of the muscle fibers with a part of the sarcoplasm separated from the muscle
      fibers. Satellite cells formed from the separated parts of the muscle fibers.

PMID- 1016731
TI  - [RNA synthesis in the circular nucleoli of hepatocytes].
AB  - By analysis of serial sections it has been revealed that the so-called ring-like
      nucleoli of hepatocytes consist of a cavity with an amorphous contents surrounded
      by fibrillar and granular material. Such nucleoli are sometimes encountered in
      normal animals; the number of ring-like nucleoli increases considerably in
      chronic pathological process caused by repeated CCl4 injections. The capacity of
      RNA synthesis in the ring-like nucleoli was revealed by means of electron
      microscopic autoradiography.

PMID- 1016732
TI  - [Topographic features of the ultrastructure of parietal cells of the gastric
      mucosa (morphometric study)].
AB  - A new methodical approach to the study of the ultrastructure of the parietal
      cells of the gastric mucosa is suggested. Electron microscopic study of
      peculiarities of the submicroscopic cell organization at the three main levels
      (the generative zone, the zone of the most active cells, and the gland floor) is
      necessarily followed by the morphometric analysis of the results obtained. Marked
      differences in the ultrastructural morphometric indices of the parietal cells
      located at various levels of the glands were demonstrated with the aid of the
      mentioned method. Despite certain difficulties, such approach can be also applied
      to the study of other cell elements of the gastric mucosa and also of many other
      tissues with continuous quick cell renewal.

PMID- 1016733
TI  - [Assessment of human regional cerebral circulation by venocclusive
      rheoplethysmoencephalography].
AB  - A possibility was shown of using the method of venocclusion
      rheoplethysmoencephalography (RPEG) for the assessment of the extent of changes
      in the cerebral circulation (CC) in individual regions of the cerebral
      hemispheres of a practically healthy man in various functional loads. The changes
      in the CC was recorded in per cent in respect to its initial background value.
      Data on the increase (by 114%) of the CC in the centralparietal region of the
      left cerebral hemisphere in movement with the right hand and on its reduction (by
      45%) in sound stimulation. In the adjacent (temporal) region the changes in the
      CC were of other character.

PMID- 1016734
TI  - [Morphofunctional express-diagnosis of liver conditons].
AB  - Methods of simultaneous detection of the vitally-essential indices of the hepatic
      tissue status by injecting neutral red vital dye into the portal vein are
      described. The liver tissue morphological status, the hepatic cell absorbing
      capacity, the blood microcirculatory efficacy and the pH shift were assessed on a
      histological preparation from the liver slice. The dye was extracted from the
      other portion of the same liver slice and the total amount of the dye absorbed
      was estimated.

PMID- 1016735
TI  - Influence of magnesium on calcium- and potassium-related responses in vascular
      smooth muscle.
AB  - The influence of Mg on Ca- and K-related responses of rabbit aortic strips was
      studied. Aortic strips bathed in either a K-free or 60.0 mM K solution were less
      sensitive to Ca in the presence of 1.2 mm Mg. Ca induced greater maximum tension
      in the aortic strips in the presence of Mg when bathed in 60.0 mM K. Addition of
      K to a K-free medium induced a slight relaxation at low concentrations (is less
      than 1.0 mm) which was Ca dependent. The relaxation was less in the presence of
      Mg. Wiolution were less sensitive to Ca in the presence of 1.2 mm Mg. Ca induced
      greater maximum tension in the aortic strips in the presence of Mg when bathed in
      60.0 mm K. Addition of K to a K-free medium induced a slight relaxation at low
      concentrations (is less thth Mg in the medium throughout the experiment (90 min),
      the threshold concentration of K, including a contractile response, was increased
      as was the maximum tension. Acute addition of Mg decreased the maximum response
      to K. When K was lowered from 5.4 to 0.0 mm a contractile response, absent in the
      presence of Mg, occurred. When the K was increased, the tension returned to
      baseline. At 25-30 mm K, the tension again increased, reaching a maximum at 40-50
      mm K. Ca uptake was stimulated at all K concentrations producing a contraction.
      Mg depressed this increase in uptake. 45Ca efflux was more rapid into a 50.0 mm
      than into 0.0 mm K solution. Mg delayed Ca efflux. It is concluded from these
      data that Mg has two components in its effect on the Ca associated with K
      responses. One is a competition with Ca at extracellular sites probably at the
      membrane, and the other is intracellular, probably a competition with Ca at
      sequestration sites.

PMID- 1016736
TI  - Standstill of nailfold capillary blood flow during cooling in scleroderma and
      Raynaud's syndrome.
AB  - Capillary blood flow in nailfold capillaries, observed continuously by capillary
      microscopy during standardized cold exposure (16 degrees C) has been compared in
      15 patients with scleroderma (SD), 6 patients with Raynaud's syndrome (RS)
      without known organic pathology, and 9 normal controls. Capillary microscopy
      affords direct observation of capillary blood flow and allows one to determine if
      standstill of capillary circulation occurs (as defined by the movement of the red
      blood cell column), a state impossible to differentiate from near zero flow by
      conventional methods. Complete standstill of capillary blood flow occurred in 10
      of 15 patients with SD and in 1 of 6 patients with RS. Intermittent standstill
      was observed in 5 of 15 SD and in 4 of 6 RS patients. In all normal subjects and
      in 1 of 6 patients with RS the capillary blood flow continued throughout the
      cooling period. Thus all 15 patients with SD and 5 of 6 patients with RS could be
      distinguished from control subjects by the development of capillary standstill on
      cooling. It is concluded that capillary microscopy can separate SD and RS
      patients from control subjects during cold exposure and may be useful in early
      diagnosis and prognosis of rheumatic syndromes and in the evaluation of therapy
      designed to improve the nutritional capillary blood flow of the skin. Whereas the
      complete standstill of capillary blood flow appears to be definitely associated
      with pathology, the intermittent standstill pattern as defined in this study may
      be an exaggerated form of flow fluctuation also seen in normal subjects. A larger
      number of subjects will have to be studied to determine whether patients with RS
      of the vasopastic type without connective tissue disease can be distinguished
      from normal subjects with low finger blood flow rates in cold conditions.

PMID- 1016737
TI  - Comparison of the excitatory and inhibitory effects of angiotensin and
      vasopressin on mammalian portal vein.
AB  - Angiotensin produced inhibitory and excitatory responses in guinea pig portal
      vein and excitatory responses in rabbit and rat portal vein. Vasopressin produced
      inhibitory responses in guinea pig and rabbit portal vein and excitatory and
      inhibitory responses in rat portal vein. In guinea pig portal vein, inhibition by
      angiotensin and vasopressin was associated with an increase in membrane potential
      which was, on average, smaller than that produced by isoprenaline, and with a
      suppression of spike discharges. Tachyphylaxis of the responses to angiotensin
      and vasopressin in portal vein was not observed and their effects were unaffected
      by tetrodotoxin, atropine and phentolamine plus propranolol.

PMID- 1016738
TI  - Density of perivascular nerves on some cerebral and extracerebral blood vessels.
AB  - The perivascular adrenergic nerves were counted as they crossed a grid-line
      superimposed on rat cerebral or femoral arteries and arterioles, and on the
      portal vein and its tributaries. The nerves were visualized with the formaldehyde
      vapor, fluorescence technique. No support was received for the hypothesis that
      cerebral vessels are better innervated than extracerebral vessels. In fact, the
      density of nerves was significantly greater on the femoral and portal vessels
      than on the cerebral.

PMID- 1016739
TI  - [Development of the renal glomerulus examined by transmission and scanning
      electron microscopy].
AB  - The kidneys of 2 to 10 days old albino rats were fixed by perfusion and examined
      by transmission and scanning electron microscopy. Furthermore, vascular casts of
      renal vessels in rats of the same ages were effectuated by injection of
      methacrylate into the aorta and observed by SEM. The observation of
      glomerulogenesis in different stages has indicated that the glomerular
      capillaries originate in the interstitial vessels which penetrate into the cleft
      formed in the wall of the renal vesicle. Initially the capillaries have an aspect
      of small sinusoids which then expand peripherally and undergo successive
      subdivisions: the anastomosis in each glomerular lobule persists. The podocytes
      originate from the cells of the renal vesicle facing the penetrating capillaries.
      The initially primitive cells branch off successively and extend around the
      expanding capillaries with their small processes -- the foot processes which
      interdigitate with the corresponding structures of the neighbour cells.

PMID- 1016740
TI  - [Descriptive anatomy of the posterior root of the trigeminal nerve (preliminary
      study)].
AB  - By 25 dissections, an angulation of 40 degrees at the emergency of the trigeminal
      nerve was observed. To the three types of fibers described by SICARD, a fourth
      type is added of V2 fibers wrapped by cranio-median and caudo-lateral fibres. Two
      groups form the motor root, a postero-superior group and an antero-inferior
      group. Anastomoses exist between the motor and sensitive roots as well as a few
      unusual sensitive rootlets.

PMID- 1016741
TI  - [Pulmonary atresia (with ventricular septal defect)].
AB  - The study has been carried out on eight cases of pulmonary atresia with
      ventricular septal defect, this abnormality involves both valvular atresia and
      the stenosis of the outflow tract of the right ventricle; that means a pulmonary
      atresia both valvular and infundibular. The atresia is always combined with a
      dextroposition of the aorta, overriding the ventricular septum; often with an
      auricular septal defect or a patency of the foramen ovale. In two cases, other
      associative caridac malformations exist : either a single ventricle or an atresia
      of the tricuspid valve. The arterial supply to the lungs may be assured by a
      persistent duct or by systemic arteries, or an association of both.

PMID- 1016742
TI  - [Effects of adaptation temperature on the development of brown adipose tissue in
      the rat].
AB  - Male Long Evans rats were acclimated to 28 degrees C, 5 degrees C or to a daily
      fluctuating temperature (Cy group). The development of brown adipose tissue (BAT)
      was compared to that of controls maintained at 22 degrees C. Acclimation to 28
      degrees C did not affect the BAT weight. After 10 days of cold exposure, the
      total BAT weight was increased in the 5 degrees C group, but not in the Cy group
      compared to controls. After four months the BAT weight was increased by about
      130% in 5 degrees C group and only by 60% in Cy. In both groups the increase of
      abdominal BAT was four times larger than the interscapular one. No histological
      difference was observed between interscapular and abdominal BAT of cold
      acclimated rats : the size of lipid droplets is smaller than in controls. The
      physiological significance of the important cold induced hypertrophy of abdominal
      BAT is discussed.

PMID- 1016743
TI  - [Study of correlations linking the volumes of the hypophyseal lobes and the
      epiphysis to body and brain weights in Chiroptera].
AB  - Study of the correlations binding the different lobes of the hypophysis and the
      pineal gland to body weight and brain weight in Chiroptera shows that the
      hypophysis is better correlated to body and brain weight than the pineal gland,
      fact that we already observed in Rodents and Primates. The allometry coefficient
      (M.R.A.) related to body weight varies from 0,80 to 0,98 for the hypophyseal
      lobes. The value of this coefficient for the pineal gland (1,60) is greater than
      that found (1,009) in another group of Mammals (Insectivora, Lemurians and
      Primates). It is less sure as the important variations in volume of this gland
      determine a lower correlation coefficient.

PMID- 1016744
TI  - [Comparison of the intraspecific growth of the endocranial organs (hypophyseal
      lobes, pineal gland, SFO) in the white Wistar rat. Rattus norvegicus
      (Berkenhout), with their interspecific growth in the rodents].
AB  - The intraspecific growth of various endocranian organs (hypophysis, pineal gland
      and SFO) in the Rat compared to a group of Rodents shows that their allometry
      coefficient/somatic weight is : close to isometry for the anterior and
      intermediate lobes of the hypophysis which is suitable for endocrine glands;
      lower and close to that found for the relation brain weight/somatic weight for
      the nervous lobe in the Rat and in Rodents; and extremely low (0,33) for the SFO
      in the Rat, which is comparable to that found in Rodents (0,44). The allometry
      coefficient found for the pineal gland is not comparable to that found in Rodents
      (1,25). Many facts (important intra and interspecific variations, existence of
      species or individuals deprived of pineal gland) seem to indicate that this gland
      is not related to an essential somatic function.

PMID- 1016745
TI  - [Fine structure of the public symphysis in the mouse].
AB  - Classical histological descriptions of the modifications of the mouse pubic
      symphysis (PS) during pregnancy did not take sufficient account of its structural
      heterogeneity. Precise morphological study of the PS, in adult male and virgin
      female mice, was carried out under light and electronic microscopy. Our
      observations on pregnant females are still imcomplete. Two regions of the PS
      should be distinguished according to their structure and evolution during
      pregnancy. The cranial region shows diarthrodial articular characteristics. This
      region disappears in the female during the first pregnancy and is not
      reconstituted after parturition. The caudal region comprises two types of cells
      in the female : typical chondrocytes and a peculiar cell-type whose function has
      yet to be defined. The latter seems to be responsible for the loose structure of
      the symphyseal cartilage and to contribute to the development of pseudocavities
      in the ligament in the final days of pregnancy. It is possible that such cells
      may be stimulated by relaxin and may secrete a hydrophilic factor such as
      hyaluronic acid.

PMID- 1016746
TI  - [Validity of descriptive characteristics in the sexual differentiation of the
      skull].
AB  - Revision of former results concerning the sexing of skulls by anatomical
      characteristcs, confirms the interest of the following data : superciliary arches
      protuberance, upper orbitary rim's shape, supramastoidian temporal crest
      protuberance. Other data have no bearing for this problem.

PMID- 1016747
TI  - [Structural correlations between dimensions of the trunk].
AB  - Almost all the great dimensions of the trunk are correlated. Some of them
      correspond to the social stratification of the biological characteristics, others
      to anatomical structures, as shown by the study of partial correlations for a
      given stature, or by multiple partial correlations for a given stature and
      weight.

PMID- 1016748
TI  - [Ultrastructural variations of synapses in the normal human cerebral cortex].
AB  - The numerous synapses in the normal human brain cortex display various aspects.
      The authors have also observed some electronic type synapses which are more
      numerous around the pericaryons. The cortical synapses are classed according to
      their synaptic vesicle richness : synapses with very few vesicles, synapses very
      rich in vesicles and synapses with a middling vesicular density. With the help of
      observations on these aspects and on variations of the synaptic cleft and that of
      the postsynaptic density, the authors advance an hypothesis on synaptic
      plasticity, the synaptic structures going from a simple intercellular contact
      (probably non functional) to a completly formed synapse and vice versa.

PMID- 1016749
TI  - [Dendroarchitectonic study of the inferior colliculus in the cat].
AB  - A network analysis of dendritic fields of the cells of the inferior colliculus
      has been performed in the adult cat. The cells of the dorso-medial nucleus have a
      smaller volume, less terminal segments and more dendritic spines than the cells
      of the ventral lateral nucleus. The bifurcation ratio of the different cells
      makes it possible to separate two different types of cells: order 2 cells with a
      strictly monochotomous branching on random segment and order 3 cells which
      dendrites grown by terminal branching on random pendant arcs.

PMID- 1016750
TI  - [The internal remodeling of compact bone in children].
AB  - The internal remodeling of bone in children is characterized by the presence of
      large osteones with irregular undermineralized deposits and large Havers canals.
      These Havers canals undergo a lateral displacement by progressive erosion of
      their internal side. These remodeling units decrease progressively in number and
      in dimensions and disappear after the age of 12 years. The metabolic necessities
      of childhood would explain the importance of the remodeling. The decentred form
      evokes a relation to strains imposed on the bone.

PMID- 1016751
TI  - Distribution of 2,4-D and picloram applied by a mist blower.

PMID- 1016752
TI  - Behavior of mallard ducklings from parents fed 3 ppm DDE.
AB  - Mallard ducks fed a diet containing 3 ppm DDE (equal to about 0.6 ppm in a
      natural succulent diet) laid eggs that contained an average of 5.8 ppm DDE;
      ducklings that hatched from these eggs differed from controls in behavioral tests
      designed to measure responses to a maternal call and to a frightening stimulus.
      In response to the maternal call, ducklings from parents fed DDE were hyper
      responsive; compared to controls, a greater percentage approached the call and a
      greater percentage of those that approached remained near the call for the
      remainder of the test. In a test of avoidance behavior, ducklings whose parents
      were fed DDE traveled shorter distances from the firghtening stimulus than did
      controls.

PMID- 1016753
TI  - Analysis of pesticide residues in 290 samples of Guatemalan mother's milk.

PMID- 1016754
TI  - Copper toxicity in the pacific oyster Crassostrea gigas.

PMID- 1016755
TI  - Mouse teratology studies with chlorodibenzo-p-dioxins.

PMID- 1016756
TI  - The acute toxicity of four herbicides to 0-4 hour nauplii of Cyclops vernalis
      Fisher (Copepoda, Cyclopoida).

PMID- 1016757
TI  - Persistence and biodegradation of hinosan in soil.

PMID- 1016758
TI  - Apparent potentiation of the cotton defoliant DEF by methyl parathion in
      mosquitofish.

PMID- 1016759
TI  - The uptake and interorgan distribution of mercury in a carnivorous crab.

PMID- 1016760
TI  - The effect of a No. 2 fuel oil and a South Louisiana crude oil on the behavior of
      the soft shell clam, Mya arenaria L.

PMID- 1016761
TI  - A descriptive evaluation of the effects of No. 2 fuel oil on the tissues of the
      soft shell clam, Mya arenaria L.

PMID- 1016762
TI  - Effects of lead nitrate ingestion on open-field behavior of mallard ducklings.
AB  - Mallard ducklings were fed a control diet or a diet containing 5, 50, or 500 ppm
      lead as lead nitrate, ad libitum, and their open-field behavior was tested after
      either 3 or 8 days on treatments. Differences in open-field performances among
      treatments were not significant. Percentage weight gain differed significantly
      among treatment groups over an 8 day period, with the least growth occurring in
      the 5 ppm treatment group.

PMID- 1016763
TI  - Nitrosation of benzoxazolinone.

PMID- 1016764
TI  - Uptake and accumulation of the nickel ion by Mytilus edulis.

PMID- 1016765
TI  - Multielement absorption by crops grown on Ithaca sludge-amended soil.

PMID- 1016766
TI  - Trace metals in teeth at birth (1957-1963 and 1972-1973).

PMID- 1016767
TI  - Acid-base changes in acute exacerbation of chronic hypercapnia in man.
AB  - Acid-base parameters were studied in 10 adult patients with chronic respiratory
      failure during spontaneous acute exacerbations of chronic hypercapnia and after
      return and stabilization of PaCO2 values at previous levels with improvement of
      clinical conditions. All factors interfering with acid-base equilibrium were
      carefully avoided. The results of this investigation confirm qualitatively those
      obtained by GOLDSTEIN et al. [7] in dog studies and those of INGRAM et al. [9]in
      human studies: increasing degrees of chronic hypercapnia tend to minimize the pH
      reduction induced by acute PACO2 changes. From a quantitative standpoint INGRAM's
      data in humans are considerably different from GOLDSTEIN's data obtained in dogs.
      Our data, although numerically limited, confirm the acute deltaH+/deltaPaCO2
      slope obtained from dogs by GOLDSTEIN et al. As data are not yet sufficient,
      definitive conclusions cannot be drawn. However the pattern of acid-base
      equilibrium changes in man in this situation seems to be similar to that observed
      by GOLDSTEIN et al. in the dog and could be described with reasonable accuracy by
      the theoretical model of LEUENBERGER et al.[13].

PMID- 1016768
TI  - Venous carbon dioxide tensions in chronic obstructive lung disease.
AB  - Eighteen patients with severe chronic obstructive lung disease (arterial PCO2
      greater than 45 mmHg arterial PCO2 less than 55 mmHg) were studied during a
      stable period of their disease. Samples of arterial blood and blood from the main
      pulmonary artery, internal jugular vein, hepatic vein, renal vein and femoral
      vein were taken by manipulating a Cournand catheter to each of these sites in
      rapid succession. An estimate of the regional distribution of blood flow was
      derived from the arterio-venous oxygen content difference of each organ. Expired
      air was collected into a spirometer. There was a redistribution of blood flow in
      these patients with chronic lung disease in accord with the observations made by
      others in the past. Carbon dioxide concentration in the venous blood depends on
      1. the blood flow to an organ, and 2. the carbon dioxide production by the organ.
      The total body CO2 production was within normal limits and there is no reason to
      suspect any alteration in carbon dioxide production by individual organs in these
      resting patients. Thus the venous CO2 levels are intimately linked with organ
      blood flow but even a substantial increase in organ blood flow cannot always
      compensate for the disorder in the lung. The exact role of CO2 in regulating the
      peripheral circulation cannot be assessed from this study but they do emphasize
      the importance of regional blood flow in regulating the concentration of CO2 in
      the venous blood and presumably in the tissues making up the organ.

PMID- 1016769
TI  - [Effects of long term hypercapnia on plasma amino acids in the rat (author's
      transl)].
AB  - Rats have been placed for periods from two hours to 22 days in a chamber, the
      atmosphere of which was enriched in CO2 (FICO2: 0.10). The acute phase of
      hypercapnia induces multidirectional changes of many plasma amino acids. Some of
      these changes lessen or become of an opposite direction during the first days of
      exposure; most of them disappear when the hypercapnic acidosis is partly
      compensated. The variety of these reactions seems due to the fact that CO2 brings
      into play various mechanisms of synthesis, circulation and catabolism.

PMID- 1016770
TI  - CO2 stores of the lung.

PMID- 1016771
TI  - Elevation in erythrocyte-l-glutamate in chronic hypoxia and hypercapnia.

PMID- 1016772
TI  - [Intermediates of erythrocyte glycolysis during three days hypercapnia in the dog
      (author's transl)].
AB  - Ten mongrel dogs (mean weight: 27 kg) awake and with an implanted femoral
      catheter have been maintained for three days in a controlled chamber (10% CO2 and
      21% O2). Arterial blood samples, taken before admission and after one, two, four,
      six, 24, 48 and 72 hours of exposure, allowed to study blood gases and acid-base
      equilibrium. Glycemia, phosphatemia, erythrocyte concentration of glucose-6
      phosphate (G-6-P), fructose-6-phosphate (F-6-P), fructose-1,6-diphosphate (F-1,6
      DP), 2,3-diphosphoglycerate (2,3-DPG), pyruvate, lactate and ATP were also
      titrated by various enzymatic methods. In addition, nine reference subjects were
      studied in air (without CO2). During the hypercapnia, [H+] rapidly increases to
      70 nmol/1, then progressively decreases after 24 hours, while [HCO3-] slowly
      rises. The glycemia stays high during the whole exposure. There is also an
      increase in inorganic phosphate, G-6-P and F-6-P, but during the first 24 hours
      only. F-1,6-DP, pyruvate and lactate remain lowered during the whole exposure.
      The 2,3-DPG diminishes after the sixth hour. These phenomena, related to the
      acidosis and probably to the phosphofructokinase inhibition don't arise in the
      reference subjects. However the latter present after a two and four hour-stay in
      the chamber a small decrease in pyruvicemia and lactacidemia.

PMID- 1016773
TI  - [CO2 storage in various organs during chronic experimental hypercapnia (author's
      transl)].
AB  - The total CO2 is titrated in liver, abdominal and leg's muscles, brain and thigh
      bone of rats exposed to 8 +/- 1% of carbon dioxide under normoxic (20-23% of O2)
      and normobaric conditions during zero, two, four or six weeks. Total (H2Ot) and
      extracellular (H2Oe) water is measured in these organs by the 3H-inulin method.
      The CO2 storage in organs is expressed in relation to the PaCO2 increase (mmol-kg
      1 fresh tissue-torr-1). During a four week hypercapnia, this CO2 increase is very
      important in bone and brain compared with that of other organs and of the whole
      body. With regard to the whole body, the bone CO2 content is still increasing
      after four weeks. The increase in extracellular bicarbonate (delta[HCO3-e]/delta
      PaCO2) is negligible (1/100 th) in comparison with the whole carbonic increase
      (delta CO2/delta PaCO2). The bone extracellular compartment diminishes in
      relation with the experimentation duration, without any significant change in
      H2Oi (Student's analysis). A factorial analysis (BENZECRI) shows that the weight
      of H2Oe in the information diminishes for all organs, both with the duration of
      normal subjects observation (ageing) and with the hypercapnia duration.

PMID- 1016774
TI  - [Metabolism during exercise in young men breathing 4% CO2 (author's transl)].
AB  - Fourteen young men (on the average 25 years), well trained (maximal oxygen
      consumption, VO2 max., between 2.7 to 3.5 1) have been studied at two different
      levels of exercise: 90 and 140 watts (about 40 and 70% of VO2 max.) in chamber,
      where the atmosphere was regulated. The subjects performed the exercise after a
      sojourn of six hours in the chamber, at the same level, either in air or in
      hypercapnic conditions (FICO2: 0.04; FIO2: 0.21); the order of the exercise tests
      was determined at random. The rise of total ventilation (VE) during exercise in
      CO2 atmosphere was particularly related to the increased tidal volume (VT). In
      spite of the larger increase of VE in hypercapnia, CO2 output (VCO2) and
      respiratory quotient (R) were lower while PaCO2 was elevated (48 at rest and 54
      mmHg during exercise). Oxygen consumption during exercise was the same in both
      conditions. Values of arterial lactic acid concentration were not different at 90
      watts level. On the contrary, at the level of 140 watts, the lactic acid
      concentration was significantly lower in CO2 atmosphere. The well known changes
      during exercise of other electrolytes (rise of Na+, K+ and total Ca) was similar
      in air and in CO2. Only the inorganic phosphorus was higher in CO2 atmosphere at
      140 watts.

PMID- 1016775
TI  - [CO2 exchange between blood and bone compartment (author's transl)].

PMID- 1016776
TI  - [Iliac crest bone CO2 and CO2/Ca ratio in man during respiratory failure
      (author's transl)].
AB  - The bone is often considered as a slow exchanger and bone sampling from the iliac
      crest, by needle-biopsy, is a commonly used and atraumatic technique; therefore
      the significance of the evolution of CO2 stores has been investigated in iliac
      crest in respiratory failure. Samples are taken before ventilation and on the
      first, second, and in some cases third days after ventilation. The results show
      that ageing is to be considered, since the CO2/Ca ratio varies according to the
      age group (0.84 at 30 years and 1.35 at 60 years). Patients with respiratory
      failure may be distributed into two main categories: hypoxic patients without
      hypercapnia, and patients with predominant hypercapnia. Hypercapnic patients may
      be differentiated from the hypoxic ones, both before assisted ventilation and on
      account of the dynamic phenomena that come into play during respiratory support
      in this group of patients. If the equilibrium state (at least five days with
      rigorously steady gazometry), before assisted ventilation, remains unknown, it is
      not possible to distribute the patients in one of these two groups. The results'
      significance is discussed, as well as the possible therapeutic applications.

PMID- 1016777
TI  - Effects of chronic hypercapnia on calcium metabolism.

PMID- 1016778
TI  - [Bone electrolytes in experimental chronic hypercapnia (author's transl)].
AB  - The role of the skeleton in electrolyte equilibrium, well known for various
      diseases, remains difficult to understand during chronic hypercapnia. An
      experimental study of normoxic (O2:21%) hypercapnia (CO2:8 +/- 1%) was carried
      out for two, four and six weeks, followed by a systematic quantitative
      determination, in thigh-bone samples of Na+, K+, Ca++, PO4--, N2 and CO2 in 72
      rats, and of total H2O and extracellular H2O (H2Oe) in 129 rats. Considering the
      mean values of groups (from 16 to 42 subjects for each group), at various times
      of hypercapnia, bone K+ was increased during hypercapnia (+3 to 4 X 10(-3) mEq/g
      fresh tissue), Ca++ diminished (--12.5 to 15.4 mEq). PO4-- and Na+ temporarily
      decreased at two and four weeks of hypercapnia. On account of the scatter of
      individual results, only the variation of K+ was statistically significant (at
      two weeks). This increase in bone K+, accompanying a partially compensated
      acidaemia, is to compare with the significant hyperkaliemia observed at two and
      four weeks, whereas this period is characterized by a decrease in K+ in skeletal
      muscle, as shown in a previous work. In a group of 72 rats, the analysis of
      correspondances and correlations points out the bone CO2 as a very significant
      variable, opposite to the variable H2Oe. PO4--is positively correlated to Na+.
      The complexity of the results does not permit a decisive interpretation of the
      phenomenon. On the other hand, this study corroborates the bone calcium loss and
      reveals the gain in bone potassium during hypercapnia.

PMID- 1016779
TI  - [The dociciliary ventilatory assistance (author's transl)].

PMID- 1016780
TI  - [CO2 "wash-out" : a factor contributing to increase myocardial performance in the
      face of hypoxia (author's transl)].
AB  - The cardiovascular system of the anaesthetized dog has been used as an
      experimental model for studying the mechanisms of the haemodynamic responses to
      hypoxia. Together with aortic and left circumflex coronary artery blood flow
      (electromagnetic flow transducers), aortic and left ventricular pressures have
      been recorded and blood has been sampled from the aorta and the coronary sinus
      (PO2, PCO2, pH). During short periods of hypoxia an improvement of myocardial
      performance has been observed both before and after administration of a beta
      adrenergic receptor blocker and a marked reduction of coronary sinus PCO2 has
      been noted. When hypoxia was caused by a mixture of nitrogen (95%) and CO2 (5%)
      an improvement of performance was observed only before administration of the beta
      blocker. The slope of the relationship between PCSCO2 and cardiac performance was
      found to be similar before and after administration of the beta-blocker and also
      similar to that observed in studies of the response of the isolated heart muscle
      to acute hypocapnia. Besides beta-adrenergic receptor stimulation, a reduction of
      coronary sinus PCO2 (CO2 wash-out due to an increase of coronary blood flow)
      could be a factor contributing to the maintenance of myocardial performance in
      the face of hypoxia.

PMID- 1016781
TI  - The effect of inhalation hypercapnia in healthy subjects on the acidity of
      gastric juice.
AB  - The pathogenesis of gastroduodenal ulcer associated with chronic pulmonary
      obstructive disease is complicated, as is the pathogenesis of these two disease
      entities separately. It is evident that a multifactorial dependence is involved
      which has not yet been resolved completely. Hence, there is no "magna cause
      morbi" but rather a multiform and dynamically variable chain of causes,
      consequences and conditions, some of which may be of genetic dependence. In the
      possible complex of causes leading to the genesis of gastroduodenal ulcer
      associated with chronic pulmonary obstructive disease, the author investigated
      the effect of isolated hypercapnia on the acidity of gastric juice and mucous
      membrane in 18 healthy normacid subjects. The results of this study that in
      healthy subjects isolated hypercapnia leads to a statistically significant
      increase in acidity of gastric juice and mucous membrane.

PMID- 1016782
TI  - [Acute hypercapnia and bile. Experimental studies in the rat (author's transl)].
AB  - The bile acid-base parameters are analyzed in 42 male Wistar rats under
      pentobarbital anaesthesia, in normal conditions of blood acid-base equilibrium.
      The reproducibility of the results is emphasized. In acute hypercapnia (FICO2 :
      0.12 for 15 min) without hypoxia, and for the same increase in PCO2, and pH
      variation is lesser in bile than in blood, thus showing an high buffer capacity.
      In vitro and in vivo comparative studies show that bile buffer capacity is about
      five times higher in vivo, independently of a possible increase in choleresis.
      Comparative studies of bile-acid-base equilibrium are effected during perfusions
      of dehydrocholate, sodium taurocholate, secretin and acetazolamide. Sodium and
      chlorine remain stable during hypercapnia both in blood and in bile ; potassium
      concentration is increased in the two media. To explain these results, the role
      of the liver is still to specify.

PMID- 1016783
TI  - Carbon dioxide and liver blood flow.
AB  - This study was designed to determine blood flow to the liver during hypercapnia
      and combined hypercapnia-hypoxia with the portal vein and hepatic artery intact
      except for placement of an electromagnetic flow probe around these vessels.
      Twenty mongrel dogs weighing 30-45 kg were anesthetized with pentobarbital and
      flow probes and occluders were surgically implanted. Ten of these dogs were
      subjected to hypercapnia alone. During inspiration of 6% CO2 in room air, portal
      vein flow increased from 588 +/- 73 ml/min to 731 +/- 113 ml/min (p less than
      .05), while hepatic artery flow did not change significantly from its control
      mean of 221 +/- 38 ml/min. In the remaining dogs, inhalation of 6% O2 resulted in
      a reduction of portal blood flow within 30 min from 527 +/- 55 ml/min to 381 +/-
      41 ml/min (p less than .01). Again, mean hepatic artery flow did not increase
      significantly above its control of 273 +/- 43 ml/min. Subsequent inhalation of 6%
      CO2 plus 6% O2 (combined hypercapniahypoxia) for 30 min in these same animals
      resulted in a significant increase of portal vein blood flow from 514 +/- 46
      ml/min to 716 +/- 116 ml/min (p less than .05). Thus, hypercapnia alone increases
      total liver blood flow, primarily by an increase in portal vein flow. Hypoxia
      results in a decrease in portal vein flow. The superimposition of hypercapnia on
      hypoxia restores blood flow to a level close to that found with hypercapnia
      alone. Hypercapnia in the range of 63 +/- 4 mmHg PCO2 overwhelms the tendency
      toward a reduction of portal vein blood flow induced by an arterial PO2 of 42 +/-
      5 mmHg in the presence of mild hypocapnia (PCO2 : 30.2 +/- 1 mmHg).

PMID- 1016784
TI  - Brain organic acids during hypercapnia.
AB  - Experiments in rats during acute and prolonged periods of hypercapnia show
      important changes in the glutamate and glutamine content of the brain.
      Compartmentation studies using labelled glutamate intracisternally injected show
      an increased turnover of the small glutamate compartment. The possible
      pathophysiological significance of these observations is discussed.

PMID- 1016785
TI  - [Effect of atmospheric pollution on respiratory function in children from Venice
      (author's transl)].
AB  - The respiratory function has been compared in two standard school populations. A
      sample, of 700 children from the industrial quarters of Venice (highly polluted)
      and 350 children from the Historic Center (not polluted), has been subjected to a
      respiratory questionnaire, clinical investigation and plethysmographic functional
      testing with measurement of airways resistance by the panting method. The changes
      in the airways resistance were related to the residing area and to the bronchitic
      episodes in the past, while the family's socio-economic situation and the living
      area did not play any role.

PMID- 1016786
TI  - [Variation of effective compliance with respiratory frequency. Test of
      inhomogeneity of the ventilatory mechanical system (author's transl)].
AB  - A decrease in effective compliance (Ce) with increase in respiratory frequency
      (f) is considered as representing an inhomogeneity in the distribution of the
      pulmonary time constants. The Ce variation in relation with f reflects the
      inadequacy of the first order linear mono-alveolar model usually used to describe
      the ventilatory mechanical properties. Such an assertion is widely accepted, but
      few attempts have been done to validate this point in patients and to determine
      the various components likely to affect the Ce, f relationship. In 171 patients,
      selected in order to sample different types of lesions of some pulmonary
      structures, the authors calculated the next functional parameters :
      VC/theoretical VC ratio, RV by dilution method and by plethysmography, airway
      resistance and distribution index of inspired gas. Moreover, by means of a
      computerised system, the effective compliance and its variation with respiratory
      frequency have been calculated. After discussion of the procedure and of the
      method used to express the compliance-frequency relationship (linear regression),
      the authors develop the arguments which allow to assert that despite the
      elementary type of expression the relation is a good discriminative parameter.
      Its signification is discussed by analysing results obtained in patients and by
      simulating a mathematical model of the ventilatory mechanics where the mechanical
      parameters are distributed. It seems likely that a negative slope of the
      compliance-frequency relationship expresses an important mechanical
      inhomogeneity. Taking into account the fact that the whole frequency-compliance
      relationship gives little information, at this moment, in the face of an
      unpleasant test for the patients, the authors propose a simplified procedure,
      adapted to the usual practice.

PMID- 1016787
TI  - Mucociliary transport in central and intermediate size airways: effect of
      aminophyllin.
AB  - Mucociliary transport and the percentage of ciliated cells were studied in large
      and intermediate sized airways (generations 0-3) of anesthetized mongrel dogs
      before and after aminophyllin administration. The mean percentage of ciliated
      cells decreased respectively from 22.0% and 25.4% in the trachea and main bronchi
      to 8.0% in the lobar and 2.7% in the segmental bronchi. The fastest mean mucous
      velocity was found in the trachea (4.9 mm/min, S.E. 1.0). Mucous velocity
      decreased 38% from the trachea to the main bronchi, 55% to the lobar bronchi, and
      66% to the segmental bronchi. A positive correlation (r = 0.75) was demonstrated
      between mucous velocity and the percentage of ciliated cells. After aminophyllin
      administration, mucous velocity increased 59% in the trachea and 27% in the main
      bronchi. No statistical difference in mucous velocity could be demonstrated in
      the smaller airways after aminophyllin, probably due to relative insensitivity of
      the method in short bronchi with low mucous velocities.

PMID- 1016788
TI  - Disturbances in pulmonary gaseous exchange in primary hyperlipoproteinemias.
AB  - Carbon monoxide diffusion (DLCO), blood gas analysis at rest and after exercise,
      distribution of ventilation and perfusion by Xenon 133 were carried out in 43
      hyperlipidemic patients, Fredrickson's types I, IIA, IIB, and IV. DLCO was
      significantly reduced in hypertriglyceridemic and to a lesser degree in
      hypercholesterolemic patients. A significant negative correlation was found
      between DLCO and triglyceride values. Significantly lower basal PaO2 values,
      which improved after exercise, were observed in both type IIA and type IV
      hyperlipemic patients. The ventilation/perfusion ratio distribution (V/Q) did not
      increase from the basal to the apical segments of the lungs in hyperlipidemic
      patients as it did in normals. The hypothesis of an alteration in pulmonary
      surface-active lipoprotein, directly related to hyperlipoproteinemia or
      indirectly caused by fat microembolism, may explain the reduced DLCO, the loss of
      V/Q gradient, and the decrease in PaO2 (which improves after exercise) observed
      in hyperlipemic patients. Disturbances in pulmonary gas exchange and PaO2
      reduction could play an important role in the pathogenesis of both angina pain
      due to ischaemic heart disease, which is frequently observed in hyperlipemic
      patients, and the postprandial angina syndrome.

PMID- 1016789
TI  - [Value and reproducibility of TLCO, TMCO and Vc in healthy subjects (author's
      transl)].
AB  - Transfer factor (TLCO) and its components (TMCO and Vc) have been measured in 47
      healthy subjects. The regressions with respect to age and body surface were close
      to those found in the literature. The reproducibility of these indices has been
      investigated in a sub-group of 5 subjects, examined at two days intervals, for 24
      to 42 days. For TLCO measured with a 16% O2 mixture, the reproducibility was good
      (coefficient of variation of 5%). For Vc and TMCO, the dispersion was more
      important and varied among the subjects. The lack of reproducibility appeared to
      be due, among other factors, to reading errors on the variables, and more
      frequently FACO. Four among these 5 subjects were asked to keep alveolar pressure
      close to atmospheric during the apnea; the coefficient of variation decreased
      from 23.5 to 7.5% for Vc and from 25.9 to 12.4% for TMCO.

PMID- 1016790
TI  - [Differential diagnosis of chronic obstructive lung disease, A statistical
      analysis of the discriminating power of various lung function tests (author's
      transl)].
AB  - Among 65 patients admitted to the hospital for chronic obstructive lung disease,
      the following pulmonary tests were systematically performed : spirometric vital
      capacity and total lung capacity, FEV1, functional residual capacity and total
      lung capacity measured by body plethysmography, airway resistance and specific
      conductance, CO diffusion capacity measured by single-breath test, N2 clearance
      by single breath oxygen dilution, and blood gases. The patients were divided into
      bronchitics, emphysematous and broncho-emphysematous, according to the clinical
      and radiological Nash's score, and to another personal score derived from the
      former. The simple and multiple correlations between the clinico-radiological
      score and the functional results are low. The clustering analysis groups the 65
      patients into four clouds of points, around two principal axes : the volume axis
      and the overinflation axis. This study indicates that the most suggestive results
      for emphysema diagnosis are increased FRC and TLC and low Tlco/V'a. The clinical
      score is not dominant for the clustering of the patients into the dynamic clouds.
      Beneath the bronchitic, the broncho-emphysematous and the emphysematous groups,
      the clustering analysis individualizes a fourth group of cases characterized by
      chronic asthma, and which were not isolated by Nash's score.

PMID- 1016791
TI  - Early detection of airway abnormalities in a selected group of population.
AB  - Functional data were collected from 5,746 males from a country region, whose ages
      ranged from 14 to 65 years. Out of this population we excluded a group of 466
      males (9%) who had abnormal results of traditional pulmonary function screening
      tests (FVC less than 80% reference values or FEV1% FVC less than 70%) and chose a
      group of 1,092 males (19%) with normal values for the above two parameters but
      with abnormal forced mid-expiratory flow. In randomly selected persons of the
      second group we found frequency dependent dynamic compliance (100%), abnormal
      maximum expiratory flow at 25% of vital capacity (98%), increased residual volume
      (76%), decreased maximum expiratory flow at 50% of vital capacity (67%), and
      increased closing capacity (57%); on the contrary static complicane and airway
      resistance were normal. To account for these results we suppose that measurement
      of forced mid-expiratory flow, abnormal values of which we obtained in
      practically one fifth of the experimental population, could represent, in
      agreement with other reports, a suitable screening test for first or early
      detection of airway abnormalities.

PMID- 1016792
TI  - [Specificity of tests for detection of small airway disease (author's transl)].

PMID- 1016793
TI  - [Methods for determination of the oxygen dissociation curve (author's transl)].

PMID- 1016794
TI  - [Relationship between the initial dimensions of bronchial ring and its
      contraction after acetylcholine (author's transl)].
AB  - Contractions produced by comulative doses of acetylcholine were studied in
      isolated canine bronchical rings from 2 to 10 mm internal diameter. The maximal
      active tension achieved was directly related to the initial caliber of the ring
      and to the amount of smooth  muscle. The maximal decrease in caliber was
      relatively greater (--39%) in the smaller than in the larger bronchi (--17%).
      However the corresponding increase in airway resistance may be predicted to be
      more important in the larger resistive bronchi.

PMID- 1016795
TI  - [Acute respiratory insufficiency in chronic pulmonary disease. Future directions
      for research].

PMID- 1016796
TI  - Emphysema as possible explanation for the alteration of expiratory PO2 and PCO2
      curves.
AB  - The present explanation of the shape of deformed expiratory partial pressure
      curves of O2, CO2, N2 and foreign gases as being caused by sequential convective
      emptying of compartments with decreasing VA/Q is put into question, since the
      same deformation can be observed in healthy subjects during simultaneous
      breathing of helium and SF6, where the SF6 curve is deformed and the helium curve
      has a normal shape. The high molecular weight of SF6 causes a delay of its
      gaseous diffusion from the peripheral air spaces of the lung. A similar delay can
      be caused by emphysematous changes such as a longer distance for diffusion, an
      increased alveolar volume and a reduction of the number of small airways, where
      the gas has to pass through. Different data from cross-sectional and longitudinal
      studies, from induced changes of bronchomotor tone, from comparison of patients
      with relatively pure emphysema and patients with airway obstruction and from
      autopsy suggest that stratification and serial inhomogeneities, caused by
      emphysema, are at least a reasonable, if not a better explanation for the
      deformation than the VA/Q concept with sequential emptying of parallel units.

PMID- 1016797
TI  - A sampling method for mean alveolar gas in normal subjects and patients with
      respiratory disease.
AB  - The paper describes an alveolar gas sampling method based on the criterion of
      equality of mean alveolar (RA) and expired (RE) respiratory quotients. Expired
      gas is sampled at an expired volume equal to VT/2 + VD by means of a mechanical
      sampler controlled by an analog computer. Eleven normal subjects and 50 patients
      with cardiopulmonary disease have been tested. When the difference between mean
      alveolar and expired respiratory quotients did not exceed 0.05, the result was
      considered to be satisfactory. Such results have been obtained in 40 patients and
      all of the normal subjects. For the remaining 10 patients, either experimental
      error and/or particular non-homogeneities in ventilation seemed to be the cause
      of the unsatisfactory results. Arterial to alveolar PCO2 differences have been
      calculated. The mean difference in normal subjects was never negative (1.86 +/-
      1.58 torr).

PMID- 1016798
TI  - [Radiological indices of pulmonary hypertension in chronic obstructive pulmonary
      disease (author's transl)].
AB  - This study attempted to correlate mean pulmonary arterial pressure with four
      radiological indices of pulmonary hypertension in 159 patients with chronic
      obstructive pulmonary disease. The mean pulmonary arterial pressure at rest
      (PAPR) and with exercise (PAPE) and four indices measured from the plain chest
      radiograph were considered. The measurements were: 1) DIP: the distance between
      the bifurcation of the right and left main pulmonary arteries, 2) DIP/T X 100
      where T is a maximal thoracic diameter, 3) R: the diameter of the right
      descending pulmonary artery, and 4) R/h x 100 where h is T/2. The mean index
      values +/- SD obtained from three observers were: DIP = 11.4 +/- 1 cm, DIP/T x
      100 = 36.1 +/- 3.5 R = 1.9 +/- 4cm, R/h x 100 = 12 +/- 2.7. An analysis of
      variation demonstrated that the interobserver error was unacceptable for R and
      R/h x 100 but small for DIP and DIP/T x 100. Increased PAP does not implicate
      high index values but high values specify abnormal PAP. The results suggest that
      DIP greater than 13 cm or DIP/T x 100 greater than 42 are diagnostic. A minority
      presented such values, but in 20 to 30% of these cases this preceded clinical or
      electrocardiographic manifestations of cor pulmonale.

PMID- 1016799
TI  - Respiratory function of infants in relation to subsequent respiratory disease: an
      epidemiological study.
AB  - Crying ventilatory function was measured in 487 infants shortly after birth. Over
      the following five years 129 infants suffered attacks of pneumonia or bronchitis.
      Their initial crying ventilatory function was compared with that of the 358
      infants who escaped these illnesses. No statistically significant differences
      were found in crying ventilatory function between these two groups of infants.
      This has been interpreted as indicating that newborn infants who subsequently
      suffer attacks of pneumonia or bronchitis do not start life with deficits in
      their ventilatory function. In the same study crying ventilatory function was
      measured in 550 infants at their first birthday; 70 had suffered attacks of
      pneumonia or bronchitis by that age and made a clinical recovery. Their crying
      ventilatory function showed no consistent difference from the 480 infants who
      escaped their illnesses. The reasons for the lack of a difference in crying
      ventilatory function is discussed.

PMID- 1016800
TI  - [Reference values of pulmonary compliance (author's transl)].
AB  - Pulmonary compliance has been measured, using a classical method in 156 healthy
      subjects aged between 18 and 74 years, breathing spontaneously. Pulmonary
      compliance (ml-cmH2O-1) was related to height in meters (H) by an allometric
      relationship such as C = aHb. As b was not significantly different from three,
      than C/H3 ratio was studied. This ratio was not dependent on age so that it was
      possible to establish that, in men, C (ml-cmH2O-1) = 36.6 H3 (m) and in women, C
      (ml-cmH2O-1) = 33.3 H3 (m). These two relationships were significantly different.
      From these relationships and from reference values of pulmonary volumes, specific
      pulmonary compliance could be calculated but since confidence limits were very
      wide, their utilization is limited. Furthermore, it is difficult to apply
      specific compliance in respiratory impairment.

PMID- 1016801
TI  - Ventilatory impairment and hypoxemia in chronic non-specific lung disease.
AB  - The relation between arterial oxygen tension at rest (Pao2) and ventilatory
      performance (VC and FEV1.0) was studied (198 determinations) in a group of 156
      patients (11 females) aged 31 to 76 (mean 52.1) years, with chronic non-specific
      lung disease (asthmatics non included). The average results were 72.7 mmHg for
      Pao2, 2.87 1 for VC, 1.32 1 for FEV1.0 and 44.9 % for the FEV1.0/VC ratio. Ninety
      per cent of the patients had ventilatory impairment (FEV1.0 less than 81 %
      predicted) and 2/3 had hypoxemia (Pao2 less than 75 mmHg). The Pao2 - spirometric
      variables linear correlation coefficients were of medium value (0.35 to 0.51),
      but highly significant due to the large number of observations. The correlation
      was high in patients with severe ventilatory defect (FEV1.0 less than 40% pred.),
      weak in those with moderate (FEV1.0 41-60 % pred.) and absent in those with minor
      or absent ventilatory impairment. In respect to the clinical type of obstructive
      disease, Pao2 and FEV1.0 showed a high correlation (r=0.69) in "bronchitics", a
      looser one (r=0.45) in "intermediate" patients, and no correlation for
      "emphysema" patients. The regression equation relating Pao2 and FEV1.0 (Pao2=64.4
      + 5.9 X litres) had too high a standard error of estimate (20 % of the mean) to
      be of practical value.

PMID- 1016802
TI  - Rebreathing and single breath pulmonary CO diffusing capacity in man at rest and
      exercise studied by C18O isotope.
AB  - The pulmonary diffusing capacity for carbon monoxide, Dco, was estimated in
      normal subjects, using both a single breath technique (DcoSB) and a rebreathing
      technique (DcoRB). In order to measure CO by mass spectrometry, the stable
      isotope C(18)O was used. In three normal subjects Dco was measured at different
      lung volumes at rest, and at different levels of bicycle exercise. DcoRB was
      found on the average 30% higher than DcoSB when compared at the same mean lung
      volume, and both increased slightly during exercise. The advantages and drawbacks
      of the rebreathing method are critically discussed.

PMID- 1016803
TI  - Diurnal variations and reproducibility of the N2 closing volume test in healthy
      subjects.
AB  - To assess the diurnal variation of closing volume measurements, 11 non-smokers
      and 10 somkers, all healthy, were tested with the single-breath nitrogen test. In
      each subject, 3 satisfactory tracings were recorded at 9:a.m., 11:a.m., 1:p.m.,
      3:p.m. and 5:p.m. on each of two consecutive days. Duplicate copies of the
      tracings were read in radom order by two independent observers. The "best+ and
      the mean values of closing volume to vital capacity ratio (CV/VC or phase 4/VC)
      and of the slppe of phase 3 were calculated. The study shows that: (1) the time
      of the day may be a source of variation of the closing volume measurements. Meals
      and cigarette smoke did not appear to be responsible for this diurnal variation,
      (2) values obtained with the "best" tracing method can, at least in some readers,
      give systematic differences with the mean of several traces, (3) individual
      variations in CV/VC and in the slope of phase 3 are the highest with the "best"
      trace analysis, and (4) the vlaues obtained by two independent readers may
      significantly differ. The differences observed between hours, although
      significant, were nevertheless small in magnitude and did not explain most of the
      variation of the measurements. Variations in trace aspect were small in some
      subjects. The reproducibility of the test was remarkable in them, at least when
      the junction of phase 4 with phase 3 was well defined. In other subjects, the
      coefficient of variation was high mainly because of varying curve shape and/or
      poorly defined departure of phase 4. This explains for a great part the intra-and
      interreader variations observed in this study.

PMID- 1016804
TI  - [Rheology of bronchial secretions and mucociliary transport (author's transl)].
AB  - Optimal relationships between mucociliary clearance and rheological properties of
      bronchial secretions expectorated by patients with chronic bronchitis have been
      analysed by successive measurements of visco-elasticity with a rotational
      rheometer and of transport velocity on frog palate mucosa. It appears that the
      role of the elastic component is predominent. Sputum characterized by very low
      strain recovery (SR less than 4 units) or conversely by very high elasticity (SR
      greater than 20 units) is transported at a low rate in comparison to that of the
      control frog mucus (relative transport rate less than 0.5). Pronounced
      hyperviscosity of sputum (no greater than 200 poises) appears also as a limiting
      factor to the mucociliary transport. The best transported secretions (relative
      transport rate greater than 0.7) are characterized by a relative elasticity (SR)
      of 4 to 13 units and a viscosity (no) of 25 to 200 poises. Under the action of
      mucolytic agents such as N-acetylcysteine, sputum initially characterized by low
      strain recovery (SR less than 4 units) is transported at a much slower rate which
      is related to the increased loss of elasticity. These results indicate that
      mucolytic drugs must be administered with great care in patients with chronic
      bronchitis. Moreover, they should not be used in patients with very low visco
      elastic secretions which reflect the non-functional state of the bronchial
      mucosa.

PMID- 1016805
TI  - [Hyperalaninaemia during acute hypoxia in the anesthetized rabbit (author's
      transl)].
AB  - Blood alanine (Ala), an important glucose precursor, has been demonstrated to
      result mainly from the transamination of pyruvate derived from glucose in muscle
      [10]. A positive relationship between blood pyruvate and blood alanine was
      reported during muscular exercise and fasting. The alanine/pyruvate relationship
      in arterial blood has been studied in male fasted anesthetized rabbits before,
      during and after a short term hypoxic stress (50 minutes). Three groups of
      animals were studied : normoxic control (FIO2 = 0.28 ; n = 3) (C), hypoxic
      hypoxia (FIO2 = 0.10 ; n = 4) (HH) and hypoxia induced by respiring the animals
      with a carbon monoxide containing gas mixture (FIO2 = 0.28, FICO = 0.002 ; n = 6)
      (HCO). The hypoxic stress was of similar magnitude in HH and HCO groups. During
      the hypoxic periods an increase of [Ala] was observed along with hyperlactatemia
      and hyperpyruvatemia. Hyperalaninemia and hyperlactatemia was higher in HH than
      in HCO groups and hyperglycemia was observed only in HH group (adrenergic
      stimulation). In normoxic conditions [Ala] correlates positively with pyruvate.
      This relationship vanishes during the hypoxic and post hypoxic periods. The
      percentage increase of [Ala] during hypoxia was larger than that of pyruvate.
      These data, as well as recent reports in the literature, suggest that elevated
      [Ala] during hypoxia may result from increased muscular production from
      glycolytic pyruvate and other amino acids and decreased hepatic utilization
      (gluconeogenesis).

PMID- 1016807
TI  - A hygienic analysis of mechanical vibrations in a voyage aboard the semicontainer
      ship M/S "Kalinowski".

PMID- 1016806
TI  - Studies of the visible spectrum of the welding arc.

PMID- 1016808
TI  - Blood coagulation and fibrinolysis system in occupational exposure to some
      chemical factors.

PMID- 1016809
TI  - Risk factors for coronary heart disease among seamen.

PMID- 1016810
TI  - The influence of Sinequan of the reactivity of the vegetative system in neuroses
      among seamen of the Polish merchant marine.

PMID- 1016811
TI  - Several observations of the survival of a population of Dermestes maculatus
      Degeer, 1774, in unfavourable trophic conditions.

PMID- 1016812
TI  - Rodents in warehouses of the Port of Gdynia and their ectoparasites investigated
      in the years 1974--1975.

PMID- 1016813
TI  - Salmonella serotypes isolated from soldiers of the Polish Contingent of the
      United Nations Emergency Forces back from Egypt.

PMID- 1016814
TI  - Lytic enzyme Vi phage III infected Salmonella typhi lysate.

PMID- 1016815
TI  - Resistance to antibiotics and sulfathiazole of Salmonella strains isolated from
      humans and animals in 1974--1975.

PMID- 1016816
TI  - Smallpox today.

PMID- 1016817
TI  - Neurophysiology of pain-peripheral aspects. Speculation concerning the
      possibility of a unitary peripheral cutaneous input system for pressure, hot,
      cold and tissue damage.
AB  - The gate theory of pain is criticized at three levels: (1) at the dorsal horn
      "gate", where pre-synaptic inhibition in the primary afferent endings may go
      beyond mere reduction of synaptic power at the afferent endings and induce
      antidromic impulses (dorsal root reflexes) that may modulate peripherally by
      blocking; (2) central to the "gate", where postsynaptic neuronal repetitive
      (epileptiform) firing is believed to be an important underlying mechanism in
      clinical chronic pain syndromes; and, (3) in the periphery, where there is more
      to input coding than a balance between the ratio of large and smaller fiber
      inputs. Contrary to the belief of many sensory neurophysiologists, the present
      authors contend that pattern theory is viable; and that specificity, while
      important and not to be ignored, should be considered as only a partially evolved
      refinement superimposed on a basic underlying spatial and temporal patterning of
      input that probably requires central decoding, which begins in the dorsal horn.

PMID- 1016818
TI  - Development of a detachable vascular balloon catheter. A preliminary report.

PMID- 1016819
TI  - Technique for accurate localization with the CT scanner.
AB  - A method for accurate localization of intracranial lesions on CT scans is
      described, using a marker wire and a radiograph exposed by the CT scanner.

PMID- 1016820
TI  - A brief trial of phenytoin therapy for thalamic pain.
AB  - Phenytoin was given in full dosage to eight patients with thalamic pain and two
      others with intractable pain resistant to other forms of treatment. Serum levels
      were monitored and correlated with dosage levels. Three patients improved
      markedly, two improved only minimally, two were unchanged, and three were worse.
      Those patients who had improved noted return of original pain on stopping
      phenytoin. The results indicate the need for a further study of the drug in
      thalamic and other chronic pain states.

PMID- 1016821
TI  - [Deceptively reassuring x-rays in injuries of the cervical spine].

PMID- 1016822
TI  - [Rejection and tolerance of human grafts].

PMID- 1016823
TI  - [Medical aspects of antibiotic resistance plasmids].

PMID- 1016824
TI  - The management of the patient with calcium stones.
AB  - Results of investigation of 800 patients with renal calculi are presented. The
      high incidence of medullary sponge kidneys (tubular ectasia) in patients of
      either sex is stressed as is the low incidence of idiopathic hypercalciuria in
      the female. Hydrochlorothiazide has been found to be highly effective in
      preventing recurrence of calcium stones in our personal experience with over 300
      patients who have been treated for as long as 14 years with this agent. The
      efficacy and mode of action of other measures advocated for stone prevention is
      reviewed.

PMID- 1016825
TI  - Size of renal calculi, recurrence rate and follow-up.
AB  - Stones smaller than 5 mm in diameter seldom need any operation other than the use
      of the stone-basket. Stones larger than 10 mm in diameter usually need an
      operation, are more often accompanied by infection, and have a higher recurrence
      rate. The size of the stone is unrelated to the level of urinary calcium or to
      body surface area. In planning the follow-up of patients with calculi the size of
      the first stone is a useful guide.

PMID- 1016826
TI  - Recurrence of infected calculi following postoperative renal irrigation with
      stone solvent.
AB  - Renacidin has been shown to dissolve small fragments of infected renal calculi in
      vitro. 34 patients with infected calculi have undergone pyelolithotomy and
      postoperative renal irrigation with Renacidin. 30 patients were women and Proteus
      was the commonest infecting organism. Renal irrigation appears to be safe if
      closely monitored and covered by antibiotic therapy. 24.4% of calculi had
      recurred at a mean follow-up of 42 months. The rate of recurrence or unilateral
      calculi was much less than that of bilateral calculi (15% vs. 40%). Persistent
      postoperative urinary tract infections later led to recurrent stone formation.

PMID- 1016827
TI  - Primary hyperparathyroidism---a review of cases in the Sheffield area.
AB  - 73 patients with primary hyperparathyroidism are reviewed. The elevated serum
      calcium was the main diagnostic index but estimation of the parathyroid hormone
      was useful confirmatory evidence when raised. A normal level does not exclude the
      diagnosis being found in 32% of patients. Intravenous methylene blue was a useful
      adjunct to surgery. 95% of the patients had relief of their hypercalcaemia after
      a single operation. 78% of patients had stones and there was a marked reduction
      in further stone formation after surgery.

PMID- 1016828
TI  - Reflux induced pelvi-ureteric obstruction.
AB  - The phenomenon of pelvi-ureteric obstruction which is induced by vesico-ureteric
      reflux is well documented but ill understood. The radiographic findings can be
      impressive to an extent that obstruction is probably often over-diagnosed. Before
      considering a pyeloplasty it is essential to confirm the true obstructive nature
      of the problem. Where the urogram is not suggestive of an obstruction a re
      implantation of the ureter will usually stop the gross pelvic dilatation. It is
      suggested that the obstruction is at least partially an active process.

PMID- 1016829
TI  - Occupational bladder tumour cases identified during ten years' interviewing of
      patients.
AB  - All patients attending the Royal Marsden Hospital with urothelial tumours have
      their occupational histories taken. About 10% of histories suggest a possibility
      of past exposure to urinary carcinogens, and on examination 4% indicate definite
      exposures justifying claims for Prescribed Industrial Disease benefit.

PMID- 1016830
TI  - Inverted papilloma of the lower urinary tract.
AB  - A study of 35 cases of inverted papilloma of urothelium confirms that it is a
      distinctive entity and typically benign. These lesions occur mainly in males, may
      be multiple, and are sometimes situated elsewhere than in or near the trigone,
      which is their characteristic site. Their precise histogenesis remains uncertain.
      It must be stressed that not all transitional cell tumours of inverted pattern
      are of this type; some will have the appearance of and behave as malignant
      tumours. The same diagnostic criteria of malignancy established for the more
      common exophytic papillary neoplasms must be applied also to the inverted
      papillary tumours herein described.

PMID- 1016831
TI  - The value of lymphography in the management of bladder cancer.
AB  - 228 bilateral pedal lymphograms in patients with bladder cancer have been
      correlated with the features of the primary bladder tumour and patient survival.
      In 70 cases, radiographic findings were correlated with operative node histology.
      The results show that it is not possible to predict accurately which cases have
      lymphatic spread without this investigation. Positive lymphograms were found in
      91 cases, and were associated with a very poor prognosis. Only 6% of patients
      with unilaterally involved iliac nodes survived 5 years, and all patients with
      bilateral iliac or para-aortic disease died within 3 years. Histological
      correlation was found in 90% of cases, and the results indicate that this
      investigation slightly underestimates the incidence and extent of microscopic
      lymphatic metastases. It is concluded that this investigation is essential in
      planning the treatment of infiltrating bladder tumours.

PMID- 1016832
TI  - Radiotherapy in the treatment of recurrent bladder cancer.
AB  - A retrospective review of 1,518 cases of transitional cell carcinoma treated by
      supervoltage irradiation is presented. The majority of patients had recurrent
      disease after previous treatment. An appreciable salvage rate has been achieved.
      A "high risk" group for distant metastases has been identified (T3) and the
      suggestion is made that adjunctive therapy be employed to deal with occult
      metastases. The place of preoperative irradiation in Stage T2 tumours has been
      referred to. It is recognised that this is an ageing population. Many die not of
      their cancer but from other causes. It is difficult to compare these results with
      others published because of problems in selection and differences in staging the
      tumours.

PMID- 1016833
TI  - Hyperthermia in the treatment of bladder tumours.
AB  - High temperature bladder irrigation was employed in 4 men as an alternative to
      cystectomy because of their age and frailty. Hyperthermic irrigation of the
      bladder from 63 degree C for 70 minutes to 82 degree C for 25 minutes caused
      partial, but not total, necrosis of the bladder. Transitional cell carcinoma
      appears to be resistant in vivo, in some cases, to heating at temperatures that
      destroy adjacent normal structures. Hyperthermic irrigation of the bladder at
      these high temperatures may be hazardous. In view of these findings we cannot
      recommend high temperature bladder irrigation as an alternative to cystectomy
      even in poor risk patients.

PMID- 1016834
TI  - Treatment of advanced bladder cancer with adriamycin and 5-fluorouracil.
AB  - The cytotoxic drug combination of adriamycin and 5-fluorouracil has resulted in a
      35% objective response in 20 patients with advanced bladder cancer. This has been
      achieved with minimal toxicity and on an out-patient basis. If the survival rate
      of patients with invasive bladder cancer is to be improved it seems likely that
      some form of systemic treatment will need to be added to the local measures
      currently in use. Further studies of different chemotherapeutic agents should
      help to define an effective and safe form of adjunvant therapy.

PMID- 1016835
TI  - The endemic bladder stones of Indonesia---epidemiology and clinical features.
AB  - Bladder stone is a relatively common disease of childhood in West Sumatra with an
      incidence of 8.3/100,000 population per year. We have studied 87 cases with a
      peak age of onset of 2-4 years and a male/female ratio of 12:1. The majority of
      these are from poor families with a diet low in protein and phosphate. Diarrhoea
      is common. The composition of the stones is primarily ammonium acid urate.
      Patients with sterile urine have shown significantly higher levels of urinary
      ammonia than controls, and only approximately 50% of patients' urine were
      infected. This is consistent with excretion of a high acid load, due both to an
      acidogenic rice diet and diarrhoea, combined with a low level of phosphate. This
      condition was once endemic in Europe but is now confined to a belt of countries
      from the Balkans through Asia.

PMID- 1016836
TI  - Distension therapy for the unstable bladder: later results including an
      assessment of repeat distensions.
AB  - 51 patients with urgency and urge incontinence of urine and enuresis have been
      treated by prolonged bladder distension. At recent follow-up, 16 patients were
      symptom free, 25 substantially improved and 10 symptomatically unchanged, at a
      mean of 13 months after distension. 13 patients whose symptoms relapsed after a
      previous distension or who failed to obtain a satisfactory improvement have had a
      further distension for a more prolonged period. The early results in this group
      are not as good as for patients having first distensions, although 2 patients
      have become symptom free, and 6 have shown a substantial symptomatic improvement.

PMID- 1016837
TI  - Clinical and experimental studies on the action of prostaglandins and their
      synthesis inhibitors on detrusor muscle in vitro and in vivo.
AB  - Experiments on muscle strips have shown that prostaglandin is naturally produced
      by the detrusor, and acts to increase the tone and spontaneous activity. An
      intimate relation between acetylcholine and prostaglandin has been demonstrated.
      Therapeutic application of prostaglandins has been successful in the treatment of
      chronic retention in women.

PMID- 1016838
TI  - Anti-reflux surgery in the congenital neuropathic bladder.
AB  - 42 refluxing ureters were re-implanted into the bladder in 28 children with
      neuropathy. In each case other measures directed at enhancing bladder emptying
      were employed. Reflux was cured in 36 of 38 ureters investigated after operation.
      The incidence of contralateral reflux following unilateral re-implantation was
      50%. 1 of 12 undilated units showed late post-operative deterioration. 22 of 28
      initially hydroureteronephrotic units either improved or stabilised  at a
      satisfactory level. In 6 children urinary diversion was subsequently performed
      because of persistent reflux (2 cases), postoperative deterioration (1 case) or
      failure of severely dilated upper tracts to improve (3 cases). Since reflux from
      a high pressure bladder can rapidly cause severe renal damage, cystography is
      indicated when there is clinical or pyelographic suspicion of its existence.
      Operative cure is needed when reflux is of major degree or if, when of lesser
      severity, it does not stop spontaneously following improved bladder emptying
      resulting from therapeutic lessening of the urethral resistance.

PMID- 1016839
TI  - The assessment of sphincteric activity in patients following trans-sphincteric
      urethral reconstruction.
AB  - 12 patients who had previously undergone trans-sphincteric urethral
      reconstruction were studied with regard to their sphincter mechanisms. The method
      of study was by urethral pressure profile and urethral voluntary sphincteric
      pressure increment. This study showed that patients may undergo trans-sphincteric
      urethral reconstruction with preservation of normal profiles and voluntary
      pressure increases indicating preservation of the "external" sphincter mechanism.

PMID- 1016840
TI  - An assessment of surgical treatment of vesical outlet obstruction in spinal cord
      injury: a review of 471 cases.
AB  - An assessment of 139 cases of outlet obstruction following spinal cord injury, in
      a consecutive series of 471 patients, is presented. The figures in relation to
      the level and extent of the spinal lesion and the type of operation
      (transurethral resection and external sphincterotomy), are reviewed. The
      incidence of repeat operation is recorded and assessed. It is concluded that
      transurethral resection and external sphincterotomy, either alone or combined,
      will relieve outlet obstruction in most cases of neuropathic bladder following
      spinal cord injury.

PMID- 1016841
TI  - A simple artificial implantable sphincter.
AB  - A device is presented for the cure of urinary incontinence in males. 16 cases
      have been operated on, 10 have been cured, 1 improved and 5 failed. Most of the
      failures were due to sepsis. Despite this small number of cases the results are
      extremely encouraging. The device, because of its simplicity, both in
      construction and ease of insertion, is considered worthy of extensive trials.

PMID- 1016842
TI  - Excretion urography in the investigation of prostatism.
AB  - The excretion urogram and urodynamic studies of 201 patients presenting with
      prostatism were reviewed. The urographic features of trabeculation and
      diverticula were found to be associated with bladder instability as shown on
      inflow cystometry but not to be associated with outflow obstruction as shown by
      the pressure-flow analysis of micturition. The bladder shadow on the preliminary
      film and the bladder size on the post-evacuation film were associated with the
      measured residual urine and with outflow obstruction. The basal prostatic filling
      defect was also associated with outflow obstruction.

PMID- 1016843
TI  - Lymphography and pelvic lymphadenectomy in carcinoma of the prostate.
AB  - 20 of 45 new patients with prostatic carcinoma have undergone lymphography and
      lymphadenectomy to determine the N-category. The overall accuracy of lymphography
      was 75%. Lymphadenectomy was a safe procedure with minimal morbidity. Although it
      would be premature to recommend its universal adoption in the management of this
      disease, its further application and study seems desirable. Full TNM
      classification has proved to be of considerable value in the management of these
      patients. This study confirms that 50% of T3 MO tumours are free of lymph node
      metastases.

PMID- 1016844
TI  - Urethroplasty in context.

PMID- 1016845
TI  - Hypospadias--problems of postoperative fistulae formation and a modified 2-stage
      procedure to reduce these.
AB  - A retrospective review of hypospadias repair reveals a high incidence of
      postoperative fistula nad stenosis. Further studies using Silicone casts have
      revealed a potential cause for the occurrence of these complications. The close
      co-operation between urologists and plastic surgeons has resulted in a grea er
      awareness of the surgical problems and the development of a simplified 2-stage
      technique which it is hoped will reduce these.

PMID- 1016846
TI  - Plasma gonadotrophic hormones, testicular biopsy and seminal analysis in the men
      of infertile marriages.
AB  - The first step in the investigation of infertile men is to obtain 2 seminal
      analyses 3 days after the previous ejaculation. Clinical assessment of testicular
      size is an unreliable means of assessing spermatogenesis and is best done by
      performing bilateral testicular biopsies. Azoospermic men with grossly elevated
      FSH levels should be advised to consider AID or adoption. Those with normal or
      mildly elevated FSH levels should undergo testicular exploration in an attempt to
      correct an obstructive lesion. Azoospermic men with subnormal FSH levels may have
      an isolated hormone defect which will respond to treatment with Pergonal.
      Different treatment programmes for oligozoospermic men depending on the results
      of the FSH and LH assays may lead to a more rational approach to therapy.
      Infertility associated with varicocele may possibly be associated with a local
      disturbance of "inhibin" and FSH concentrations.

PMID- 1016847
TI  - The development of the isthmo-optic nucleus.
AB  - The nucleus of origin of centrifugal fibers to the retina (the so-called isthmo
      optic nucleus - ION) has been used as a model for the study of the major features
      of neural development, from the period of cell proliferation until after the
      formation of its afferent and efferent connections. 3H-thymidine autoradiography
      has established that in the chick cells of the ION are generated (i.e., become
      post-mitotic) between the middle of the 5th and the end of the 7th days of
      incubation. The first-formed cells are found in the ventrolateral part of the
      nucleus, while those that are generated at successively later stages come to
      occupy progressively more medial and dorsal positions within the nucleus. The
      anlage of the ION can be identified on the 8th day of incubation, and by the 11th
      day, when it is numerically complete, it occupies a prominent position in the
      caudo-dorsal part of the midbrain tegmentum at the level of the IVth nerve
      nucleus. At this stage the nucleus contains about 22,000 neurons, and shows no
      signs of cytoarchitectonic differentiation. Between the 13th and 17th days of
      incubation, about 60% of the neurons in the nucleus degenerate; as a result of
      this degeneration, the arrival of afferent fibers, and the growth of the cells'
      processes, the nucleus comes to have its characteristic adult form of a complex,
      folded, bilaminar sheet, in which each part of the retina is precisely
      represented. Experiments based on the retrograde transport of horseradish
      peroxidase (HRP) from the eye indicate that the first centrifugal fibers, in the
      isthmo-optic tract (IOT), reach the retina on the 10 day of incubation, and by
      the 12th day all but about 5% of the neurons in the ION can be retrogradely
      labeled in this way...

PMID- 1016848
TI  - Brain circuits for consciousness.
AB  - The question is explored of the location of consciousness in the human brain. The
      author's own studies of defects of consciousness as the result of the splitting
      of the corpus callosum are described and disorders of consciousness associated
      with damage to other specific areas of the brain, are reviewed. A circuit
      spanning the brain is described which stretches from the parietal lobe at one
      side to the parietal lobe at the other and includes the splenium of the corpus
      callosum. The medial banks of the hemispheres, the callosal as well as the
      cingulate areas, are also thought to be involved.

PMID- 1016849
TI  - Telencephalon of the lizard Gekko gecko (Linnaeus): some connections of the
      cortex and dorsal ventricular ridge.
AB  - Interhemispheric connections of the telencephalon in the lizard, Gekko, were
      studied with anterograde degeneration methods following lesions variously placed
      in the medial, dorsal, and lateral cortices and/or the dorsal ventricular ridge
      (D.V.R.). After lesions involving dorsal cortex, the medial wall, and the DVR,
      the majority of degenerated fibers decussate in the hippocampal commissure and
      terminate in the septum, medial wall, dorsal cortex, and the lateral edge of the
      DVR contralaterally. Lesions confined to dorsal cortex result in a similar
      pattern of degeneration, while lesions confined to the lateral wall result in
      degeneration in the contralateral lateral cortex, DVR and striatum, mainly via
      the anterior commissure. Some variation has been reported on the pattern of
      interhemispheric projections among reptiles studied to date; two possible
      interpretations of the data are that (1) dorsal cortex may be homologous as a
      field to parts of both neocortex and the hippocampal formation of mammals or (2)
      only the lateral part of dorsal cortex may be homologous to neocortex.

PMID- 1016850
TI  - Behavioral correlates of 'tectal compression' in goldfish. I. Intensity and
      pattern discrimination.
AB  - Goldfish were trained to perform visual intensity and pattern discriminations.
      Three groups of fish had bilateral ablation of the caudal optic tectum, a fourth
      consisted of unoperated controls and a fifth group consisted of sham-operated
      controls. The fish were tested after various postoperative intervals ranging from
      19 to 147 days. The lesions produced modest deficits in intensity discrimination
      irrespective of postoperative interval. The fish that began training on the
      pattern discrimination after 14-18 postoperative days showed no improvement in
      performance. Fish that began training after 39 postoperative days showed
      improvements in performance after about 65 postoperative days. The group that
      began training 158-160 postoperative days showed steady and persistent
      improvements in discrimination performance. The results suggest that improvements
      in pattern vision after partial tectal ablation follow the same time course as
      compression of the retinotectal map after partial ablation of the tectum.

PMID- 1016851
TI  - Behavioral correlates of 'tectal compression' in goldfish. II. Visual acuity.
AB  - Visual acuity was measured in three normal goldfish and two goldfish in which the
      caudal optic tectum had been ablated bilaterally. Compression of the retinotectal
      map was assumed to have occurred in the two operated fish, which were tested more
      than 200 days after surgery. The results indicated that the visual acuity of the
      normal fish ranged from 0.94 to 0.95 degrees of visual angle. The visual acuity
      of the fish with presumed compression of their retinotectal maps ranged from 1.91
      to 2.07 degrees. The results suggest that compression of the retinotectal map
      occurs at the expense of the spatial-resolution ability of the visual system.

PMID- 1016852
TI  - [Phospholipids of the vinyl ether type in the cytosol fraction of the brain].

PMID- 1016853
TI  - [The morphology of Krabbe's globoid-cell leukodystrophy].

PMID- 1016854
TI  - [Peculiarities in the histological picture of the liver in cold-blooded
      vertebrates].

PMID- 1016855
TI  - [Surgery of the epithelial bodies].

PMID- 1016856
TI  - [Memory testing in rats after loading with sudan yellow 3G].

PMID- 1016857
TI  - [The epidemiology of viral hepatitis].

PMID- 1016858
TI  - [Determination of the quantitative significance of various risk factors in
      physiological aging].

PMID- 1016859
TI  - [Dynamic characteristics of manometric systems].

PMID- 1016860
TI  - [Thrombolytic therapy].

PMID- 1016861
TI  - [Surgery for hydrocele using the Lord technic].

PMID- 1016862
TI  - [Normal and risk pregnancy monitored by means of HPL (human placental lactogen)].

PMID- 1016863
TI  - Human values in medicine.

PMID- 1016864
TI  - Plasma cell sarcoma complicating a case of multiple myeloma.

PMID- 1016865
TI  - [Home air pollutants: their role in broncho-pulmonary pathology].

PMID- 1016866
TI  - [Effects of non-occupational air pollutants on the tracheo-bronchial mucosa
      (bronchial cancer excepted)].

PMID- 1016867
TI  - [Attempt of correlation between the data on atmospheric pollution in Bordeaux and
      school absenteeism of children due to broncho-respiratory causes].

PMID- 1016868
TI  - The bronchi in the fibrotic forms of the extrinsic pulmonary granulomatoses.

PMID- 1016869
TI  - [Bronchial lesions in rheumatoid pulmonary fibrosis].

PMID- 1016870
TI  - [Bronchial changes in pulmonary fibrosis].

PMID- 1016871
TI  - [Large bronchi in diverse cases of pulmonary fibrosis].

PMID- 1016872
TI  - The mineral dust load of human lungs.
AB  - Studies of the dust content of lungs from non-industrially exposed city dwellers
      have shown that many people build up during life a total dust load of 2 grammes
      or more. This dust load may include up to 17 X 10(6) mineral fibres large enough
      to be visible with the light microscope and 360 X 10(8) fibres visible only by
      electron-microscopy. All lungs examined contained a small percentage of fibres
      that appeared structurally similar to chrysotile asbestos. It was found that the
      total dust content and content of light microscope sized mineral fibres was much
      lower in a non-industrialised city than in one with a high level of heavy
      industry, but levels of electron-microscope sized fibres did not differ markedly
      between the two groups. It would appear that these very small fibres are part of
      a general mineralogical background rather than resulting from industrial
      atmospheric pollution. This was further indicated by the fact that many of the
      dust particles, including large numbers of the fibrous ones proved to be derived
      from diatom skeletons.

PMID- 1016873
TI  - [Use of a small computer in ergospirometry].

PMID- 1016874
TI  - [Blood gas analysis by means of computer calculation of the acid-base
      equilibrium].

PMID- 1016875
TI  - [Use of a computer in pulmonary function tests].

PMID- 1016876
TI  - [Simultaneous memorization of data on microfilm and magnetic tapes].

PMID- 1016877
TI  - A new method of intrathoracal biopsy using thoracoscope and tissue adhesive.

PMID- 1016878
TI  - [Open thorax pleuro-pulmonary biopsies. Study of optimal conditions for sampling
      (apropos of 141 cases)].

PMID- 1016879
TI  - [Indications and results of open thorax pulmonary biopsies bilateral disseminated
      processes].

PMID- 1016880
TI  - [Open thorax pulmonary biopsy in bilateral diffuse lung diseases].

PMID- 1016881
TI  - [Pleuro-pulmonary surgical biopsy in high pulmonary risk patients].

PMID- 1016882
TI  - [Nonsurgical treatment of nontumoral tracheal stenoses].

PMID- 1016883
TI  - [Rheology of expectoration and control of mucolytic therapy by use of a
      thermostatic capillary viscometer].

PMID- 1016884
TI  - [Functional diagnosis of pulmonary fibrosis].

PMID- 1016885
TI  - Sarcoid reactions in pulmonary neoplasms.

PMID- 1016886
TI  - [Transplantation antigens].

PMID- 1016887
TI  - [Molecular biology of a genetic malady: thalassemia].

PMID- 1016888
TI  - [Pulmonary function testing].

PMID- 1016889
TI  - [Treatment and rehabilitation of spinal cord-injured patients and amputees].

PMID- 1016890
TI  - [Isotope methods of study of cerebral blood flow; current aspects and prospects].

PMID- 1016891
TI  - [Painful diseases of the anus].

PMID- 1016892
TI  - [Value of tiapride in treatment of the behavior disorders of chronic alcoholism].

PMID- 1016893
TI  - Effect of some lipid compounds on the development of Colorado potato beetle
      (Leptinotarsa decemlineata Say).

PMID- 1016894
TI  - A study on the role of some protein compounds in the development of Colorado
      potato beetle (Leptinotarsa decemlineata Say).

PMID- 1016895
TI  - Exo-ploygalacturonate lyase of Fusarium culmorum.

PMID- 1016896
TI  - Resolution of chloroplast lamellar proteins by sodium tetradecyl sulphate gel
      electrophoresis.

PMID- 1016897
TI  - Different frequencies of point mutations in barley ears after treatment with N
      nitroso-N-methylurea.

PMID- 1016898
TI  - The structure of the alimentary canal and the dimensions of the mucosa in the
      smooth newt (Triturus vulgaris L.).

PMID- 1016899
TI  - Effect of Trichinella spiralis (Oven, 1835) infection on ultrastructure of
      epithelium of small intestines in germfree or conventional mice.

PMID- 1016900
TI  - The effect of insulin or 2-deoxy-D-glucose administration of body temperature
      during physical exercise in dogs.

PMID- 1016901
TI  - Measurements of mineral content and its crystallinity in some selected bones of
      rats surviving twenty days in conditions of weightlessness.

PMID- 1016902
TI  - Scintillation autoradiography as a quick method for detection of radioactivity in
      cells and tissues.

PMID- 1016903
TI  - New Siphonaptera from the fauna of Bulgaria.

PMID- 1016904
TI  - Tabanus castellanus Strobl, 1906 (Diptera, Tabanidae)--a species distinct in the
      European fauna.

PMID- 1016905
TI  - Abundances of Mn, Na, Zn, Co, Ag, U and Ba in males and females of Dioecocestus
      asper (Mehlis, 1831) (Cestoda: Dioecocestidae).

PMID- 1016906
TI  - Effect of methoxychlor on the embryonic development and respiratory metabolism of
      Fasciola hepatica (Trematoda) and Triaenophorus nodulosus (Cestoda) embryos.

PMID- 1016907
TI  - Effects of the insulin-secreting action of lysine on some metabolic parameters of
      blood and of tissues in subdiabetic rats.

PMID- 1016908
TI  - [Diffusion of new technics in medical ambulatory practice: opinions and behavior
      of liberal physicians. Preliminary results of a survey].

PMID- 1016909
TI  - [Statistical publications on medical organization].

PMID- 1016910
TI  - [Emergency admissions at the hospital. Comparative study of regional hospital
      centers].

PMID- 1016911
TI  - [Medical care in France and the United States].

PMID- 1016912
TI  - [Preliminary results of a national survey on midwives].

PMID- 1016913
TI  - [Statistical study of patients taking cures at spas in the Paris area].

PMID- 1016914
TI  - Isoelectric points and molecular weights of salt-extractable ribosomal proteins.
AB  - Rat liver ribosomes prepared in low salt buffer contain basic and acidic proteins
      not found on ribosomes washed in high salt buffer. Proteins extracted from liver
      ribosomes by 500 mM KCL were characterized by acid urea-polyacrylamide gel
      electrophoresis, sodium dodecyl sulfate - polyacrylamide gel electrophoresis and
      gel isoelectric focusing. The salt-solubilized proteins contain 12 polypeptides
      with a molecular weight over 67000, several polypeptides with molecular weights
      less than 67 000, and three polypeptides whose molecular weight exceeded 130 000.
      Ten to 12 of the proteins were basic, and about 24 acidic proteins were partially
      or wholly extracted from the ribosomes. Four of the acidic proteins have
      isoelectric points less than 4.5.

PMID- 1016915
TI  - Preparation of active run-off 80S ribosomes and their subunits from mouse liver.
AB  - A method is described for the preparation of active "run-off" 80S ribosomes and
      40S and 60S subunits of mouse liver. A polysome preparation was incubated at 37
      degrees C for 10 min under the condition for protein synthesis (4 mM Mg2+, 100 mM
      KCL). Puromycin (10 mM)and 2 M KCL were added to a final concentration of 0.1 mM
      and 500 mM, respectively, and the reaction mixture was further incubated at 37
      degrees C for 10 min. This latter treatment destabilized small polysomes and
      "stuck" 80S particles, which were remaining after the first incubation, leading
      to complete release of 40S and 60S particles. Thus, the present method minimized
      variations in yield of subunits due to polysome preparations and preincubation
      conditions. The subunits were separated by sucrose density-gradient
      centrifugation or recovered by precipitation following reassociation into 80S
      particles (run-off 80S). The reformation of 80S particles from the subunits
      occurred spontaneously at 5 mM Mg2+ and 100mM KCL. The isolated 40S and 60S
      subunits, separately, showed low phenylalanine-incorporating activity in the
      presence of poly(U), but when recombined, polymerized up to 10 phenylalanine
      residues per couple.

PMID- 1016916
TI  - Purine catabolism in man: inhibition of 5'-phosphomonesterase activities from
      placental microsomes.
AB  - The 5'-phosphomonoesterase activity of 5'-nucleotidase (EC 3.1.3.5) and alkaline
      phosphatase (EC 3.1.3.5) participates in the catabolism of purine ribonucleotides
      to uric acid in humans. Initial velocity studies of 5'-nucleotidase suggest a
      sequential mechanism of interaction between AMP nad MgCl2, with a Km of 14 and 3
      muM, respectively. With product inhibition studies the apparent Ki's for
      adenosine, inosine, cytidine, and inorganic phosphate were 0.4, 3.0, 5.0, and 42
      mM, respectively. A large number of nucleoside mono-, di-, and tri-phosphate
      compounds were inhibitors of the enzyme. Allopurinol ribonucleotide, ADP, or ATP
      were competitive inhititors when AMP was the substrate, with a Ki slope of 120
      muM. The phosphomonoesterase activity of human placental microsomal alkaline
      phosphatase had a pH optimum of 10.0 and had only 18% of maximum activity at pH
      7.4. Substrates and inhibitors included almost any phosphorylated compound. The
      Km for AMP was 0.4 mM and the apparent Ki for Pi was 0.6 mM. Activity was
      increased only 19% by 5 mM MgCl2. These observations suggest that 5'-nucleotidase
      and alkaline phosphatase may be inhibited by ATP and Pi, respectively, under
      normal intracellular conditions, and that AMP may be preferentially hydrolyzed by
      5'-nucleotidase.

PMID- 1016917
TI  - Converging evidence for automatic perceptual processing in visual search.

PMID- 1016918
TI  - The Western psychiatrist and his non-western clientele. Transcultural experiences
      of relevance to psychotherapy with Canadian Indian patients.

PMID- 1016919
TI  - Supernatural influence in psychopathology. Puerto Rican folk beliefs about mental
      illness.

PMID- 1016920
TI  - Children of immigrants. The adjustment of Ugandan Asian primary-school children
      in Canada.

PMID- 1016921
TI  - Psychiatry in Ethiopia.

PMID- 1016922
TI  - Psychiatric disorders among natives and non-natives in Saskatchewan.

PMID- 1016923
TI  - The extent of mental disorder. Beyond the layman's madness.

PMID- 1016924
TI  - Youth and contemporary religious movements: psychosocial findings.

PMID- 1016925
TI  - Outcome of hospitalization of geriatric patients in public psychiatric wards in
      New York and London.

PMID- 1016926
TI  - The double blind method.

PMID- 1016927
TI  - Therapeutic abortion and psychiatric disturbance in Canadian women.

PMID- 1016928
TI  - Female physicians as psychiatric patients.

PMID- 1016929
TI  - Comparison of depression inventories in a clinical population.

PMID- 1016930
TI  - Depression in a university clinic population.

PMID- 1016931
TI  - Psychiatry in family practice.

PMID- 1016932
TI  - Intravenous methylphenidate as a diagnostic and psychotherapeutic instrument in
      adult psychiatry.

PMID- 1016933
TI  - The effect of liquor store strike upon psychiatric hospital admissions for
      alcoholism.

PMID- 1016934
TI  - Electroconvulsive therapy (ECT)

PMID- 1016935
TI  - Decreased uptake of orotate in kidney tumors.
AB  - The uptake of isotope by three transplanted kidney tumors after i.p. injection of
      3H-labeled orotate was less than 5% of that in the host kidney cortex. A decrease
      of similar magnitude in the uptake into the acid-soluble tissue fractions from
      the kidney tumors was observed with very low incorporation into RNA relative to
      the host kidney cortex. Total uptake of orotate-3H and incorporation into RNA
      were several fold higher in the normal kidney cortex than in the kidney medulla
      and for the kidney cortex both parameters were less in young than in old rats.
      The uptake of uracil-3H by two kidney tumors was approximately 40% of that in the
      kidney cortex of host rats. Although the uptake of orotate-3H in kidney cortex
      was greater than that for uracil-3H the reverse situation was observed with
      kidney tumors, indicating that renal neoplasia in the rat is accompanied by an
      altered pattern of uptake of these metabolites.

PMID- 1016936
TI  - Shapes of carcinogenic benz[alpha]anthracenes: an x-ray crystal structure
      analysis of 12-methylbenz[alpha]anthracene.
AB  - The crystal structure of the moderately active carcinogen 12
      methylbenz[alpha]anthracene (12-MBA) has been determined by application of direct
      methods to X-ray single-crystal diffraction data. Least-squares refinement to a
      residual R = 0.09 over 929 independent reflections enabled carbon positions to be
      established with apparent e.s.d.s. of atomic coordinates about 0.008 A. Deviation
      from planarity is exemplified by the 15.5 degrees inclination of the benz ring
      (A) to the anthracene nucleus and by the 0.89 A distance of the methyl carbon out
      of the best plane through the whole benzanthracene nucleus. Comparison with the
      structure of the highly carcinogenic 7,12-dimethylbenz[alpha]anthracene (7,12
      DMBA), and with the recently solved structures of the weak carcinogen 1-MBA and
      the extremely weak carcinogen 1,12-DMBA, shows a close similarity in the
      anthracene parts; in 1-MBA, and 1,12-DMBA, the phenanthrenic K-region bond is
      close to 1.34 A and the M-region bond about 1.38 A. In 12-MBA, overcrowding in
      the 'bay' region causes the central anthracene ring C and the benz ring A each to
      be bent about 10 degrees in opposite directions from the phenanthrenic B ring,
      much as in 1-MBA and 7,12-DMBA, but less than in 1,12-DMBA; the 12-methyl carbon
      lies about the same distance (0.55 A) above the anthracene plane in 12-MBA as in
      1,12-MBA and 7,12-DMBA.

PMID- 1016937
TI  - Temporal changes in chromatin isolated from Friend virus-infected mouse spleens.
AB  - Differences noted in enzyme II directed RNA synthesis under varying salt
      conditions in nuclei isolated from uninfected and Friend virus (FV)-infected
      spleen cells, have been attributed to chromosomal modifications (Babcock and Rich
      1973). This investigation was undertaken to determine if compositional changes
      occur in the chromatin of FV-infected spleens, which correlate with an altered
      rate of synthesis by enzyme II. A quantitative study of the chromatin
      constituents at various times after infection indicated that they vary in the
      same temporal manner as the rate of RNA synthesis in isolated nuclei. Relative to
      DNA, RNA, histone, and nonhistone protein reached a maximum at 14 days
      postinfection. This was followed by a gradual decrease during the remainder of
      the infection. Chromatin endogenous DNA-dependent RNA polymerase activity varied
      in the same manner, suggesting that RNA synthesis directed by enzyme II is
      modulated by chromosomal proteins.

PMID- 1016938
TI  - Theoretical prediction of mutagenicity and carcinogenicity of chemical
      substances.
AB  - The pseudopotential with respect to free electrons has been calculated for a
      series of chemical substances. These potentials are different for carcinogenic,
      mutagenic-carcinogenic, and mutagenic substances thus allowing the theoretical
      prediction of their biological activity. The reaction mechanism is discussed on
      the basis of the interaction potential.

PMID- 1016939
TI  - Minimizing false negatives in electron microscope searches for virus or other
      specific features of cancer cells.
AB  - Electron microscopic searches for virus particles and other specific features of
      cancer cells involve exceptionally poor sampling statistics. It is probable that
      most searches conducted in the past were of limited value in establishing whether
      such viruses or special features are associated with one or more tumor types. On
      the other hand, in a few cases, the electron microscope has provided the first,
      or even the only, evidence of virus particles. A radical change in the way the
      electron microscope is applied to this problem is suggested whereby a high
      voltage microscope is used to examine thicker sections and an image-processing
      arrangement is used to focus and select images and to search the images for virus
      particles. It is suggested that it is important to distinguish virus producers
      amongst oncogenic viral genome carriers since these may be in a more advanced
      state of tumor induction and may be capable of transmitting the virus to others.

PMID- 1016940
TI  - Behavior of rat liver catalase during electrophoresis in a pH gradient.
AB  - Investigations were conducted on the distribution of rat liver catalase
      subsequent to electrofocusing in a pH gradient. Differences were observed
      depending on the enzyme being extracted from the total mitochondrial fraction,
      from the supernatant of the homogenate or from purified peroxisomes. Catalase
      solubilized from the total mitochondrial fraction exhibits an apparent
      isoelectric point lower than that of catalase derived from the supernatant.
      Catalase released from purified peroxisomes shows a behavior similar to that of
      the supernatant catalase. It has been concluded that, in a total mitochondrial
      fraction, a factor is present that alters the electric charge of the catalase
      molecule during or after the extraction of the enzyme. This factor is probably
      associated with lysosomes existing together with peroxisomes and mitochondria in
      a total mitochondrial fraction. As a matter of fact, the addition of an extract
      of purified lysosomes to purified peroxisomes or to supernatant will cause a
      shift towards a more acid pH of catalase distribution subsequent to
      electrofocalization.

PMID- 1016941
TI  - Transfer RNA and aminoacyl tRNA synthetases in hormone dependent and independent
      mammary tumors of GR mice: II. Isoacceptor tRNA's in hormone dependent and
      independent mammary tumors of GR mice.
AB  - The chromatographic elution profiles of 15 aminoacyl tRNA's from dependent and
      independent mammary tumors of GR mice have been studied using the reversed phase
      chromatography (RPC 5). The seryl tRNA from the dependent tumor displayed three
      isoacceptor peaks while only two isoacceptor peaks were observed in the case of
      the independent tumor when the tRNA's were charged in the presence of the GR mice
      liver enzyme. Charging of the tRNA's with radioactive leucine by homologous and
      heterologous enzyme revealed major differences in the leucyl isoacceptor species.
      The homologous dependent tumor system charges five leucyl tRNA species while the
      independent system only charges four. The leucyl tRNA from the dependent tumor
      has a new peak which is only recognized by its own enzyme, but this peak is
      either suppressed or completely absent in the independent tumor.

PMID- 1016942
TI  - Carcinogenic effects of different nitroso-compounds in chinese hamsters: N
      dibutylnitrosamine and N-nitrosomethylurea.
AB  - Three hundred and twenty Chinese hamsters (Cricetulus griseus) (CH) were
      subcutaneously (s.c.) treated with 1/5, 1/10 or 1/20 the mean lethal dose (LD50)
      of N-dibutylnitrosamine (DBN) or N-nitrosomethylurea (NMU). In several respects
      these two substances produced the same organotropy in the CH as in the Syrian
      golden (SGH) and European hamsters (EH). DBN prolonged lung tumours and neoplasms
      of the injection site. NMU induced tumours of the injection site only.

PMID- 1016943
TI  - Polycyclic aromatic hydrocarbons in human bronchial carcinoma.
AB  - A study was made to determine whether and to what extent polycyclic aromatic
      hydrocarbons (PAH) are present in human bronchial carcinoma. Twenty-four
      carcinomas, obtained from surgical operations and autopsies, were examined. The
      samples were tested for 12 PAH; these were determined by direct fluorescence
      analysis on thin-layer plates. Only 4 of the 12 PAH were detected in the
      cancerous tissue: benzo(a)pyrene, fluoranthene, benzo(ghi)perylene. Beno(a)pyrene
      was found in all carcinomas. The reasons for increased concentration of the
      detected PAH in cancerous tissue are discussed with respect to deposition and
      elimination of inhaled particles as well as the metabolism of these compounds.

PMID- 1016944
TI  - A further pancreatic carcinogen in Syrian golden hamsters: N-nitroso-bis(2
      acetoxypropyl)amine.
AB  - Weekly subcutaneous injection of N-nitroso-bis(2-acetoxypropyl)amine (BAP) for 20
      weeks to Syrian golden hamsters induced pancreatic neoplasms in 50% of the
      animals, as early as 15 weeks from the start of treatment. The carcinogenic
      potency and organotropic spectrum of BAP were similar to those of N-nitroso-bis(2
      hydroxypropyl)amine (BHP). Metabolism studies indicated that BAP was readily
      converted in vivo to BHP and that BHP was also the major urinary metabolite.

PMID- 1016945
TI  - Human breast carcinoma: heterotransplantation to newborn rats.
AB  - Cultured cells from a human breast carcinoma (HBC) were injected subcutaneously
      in newborn cortisone-treated Sprague-Dawley rats (CNBR). Tumors of predominantly
      epithelial nature appeared in all within 30 days, and wipespread metastases
      occured often. Cells cultured from these tumors rapidly produced similar tumors
      in CNBR. Rat-to-rat passage by implanting fragments of tumor tissue was 100%
      successful in CNBR. The in vivo model described is simple and inexpensive.

PMID- 1016946
TI  - Tumorgenicity of L cell derivatives and hybrid cells derived from them.
AB  - Hybridization studies on high and low malignant L cell derivatives support our
      previous conclusions, in showing that crosses between highly tumorigenic and
      poorly tumorigenic lines to a marked suppression of the malignant phenotype.
      Malignant behaviour is not, however, suppressed when cells from one highly
      tumorigenic line are crossed with those of another tumorigenic line. The present
      results show further that these rules apply even when all the cells crossed are
      closely related derivatives of one cell line.

PMID- 1016947
TI  - Investigations on esophageal carcinogenicity by methyl-phenyl-nitrosamine and
      ethyl alcohol in rats.
AB  - Methyl-phenyl-nitrosamine was administered subcutaneously or orally to Sprague
      Dawley rats. Carcinomas of the esophagus were found in 46-87% of the animals. The
      induction period of tumors was 170-290 days. Simultaneous application of 25%
      ethyl alcohol given instead of drinking water did not alter tumor incidences and
      induction periods. Hepatotoxic effects of ethyl alcohol were not observed. Mean
      life expectancies of animals were not reduced.

PMID- 1016948
TI  - Vaccinia virus: the possibilities of its oncogenicity in humans.
AB  - Contrary to the earlier generally accepted view that vaccinia virus replicates in
      the cytoplasm only of suitable target cells, steadily accumulating data show that
      the viral genome spends a limited period of time in the nucleus. This, together
      with the many cases where a close association has been suspected or established
      between skin cancer and vaccination, suggests that vaccinia virus may, under
      certain yet undefined physiological conditions, act as an oncogenic virus in
      humans.

PMID- 1016949
TI  - Early membrane alterations in isolated cells treated in vitro with chemical
      carcinogens.
AB  - Membrane alterations were detected in isolated epithelial cells treated in vitro
      with 5 x 10(-4) M dibutylnitrosamine (DBN) or 1.2 x 10(-9) M diethylstilbestrol
      (DES) for 30 min. Addition of DBN to bladder cells and DES to endometrial cells
      elicited a striking increment in Con A-mediated hemadsorption, but not Con A
      binding, to the treated cells as compared to those not treated with carcinogens.
      Concomitantly, release of the lysosomal proteinase, cathepsin B1, to the
      extracellular medium was essentially doubled in the preparations exposed to the
      carcinogens, as compared to corresponding controls. The increased cellular
      hemagglutination in response to carcinogen treatment was significantly reduced by
      prior incubation of the epithelial cells with ovomucoid, a proteinase inhibitor
      that suppresses the activity of cathepsin B1.

PMID- 1016950
TI  - Modification of photocarcinogenesis by two immunosuppressive agents.
AB  - The carcinogenic effect of ultraviolet radiation (UVR) on the skin of hairless
      (hr) mice was modified by two immunosuppressive agents, rabbit anti-mouse
      lymphocytic serum (ALS), and 6-mercaptopurine (6MP). Daily exposure of mice to
      UVR resulted in multiple tumor production. Carcinogenesis was measured in terms
      of affected mice (prevalence) and numbers of tumors produced. By both criteria,
      photocarcinogenesis was enhanced by ALS but inhibited by 6MP.

PMID- 1016951
TI  - Carcinogenic effects of a single dose of diethylnitrosamine in three unrelated
      strains of mice: genetic dependence of the induced tumor types and incidence.
AB  - The carcinogenic effects of a single dose of diethylnitrosamine (DEN) were
      studied in three inbred strains of mice. The most predominant tumors observed
      were lung adenomas, leukemia, and liver tumors. Mice of strain AKR/J developed
      both leukemia and lung tumors; SWR/J mice were most susceptible to lung tumor
      development; and in C57BL/6J mice liver lesions including liver tumors occurred.
      The influence of the genetic background on the organ susceptibility to DEN
      carcinogenesis is discussed.

PMID- 1016952
TI  - Proliferation of endocrine (APUD-type) cells during early N-diethylnitrosamine
      induced lung carcinogenesis in hamsters.
AB  - Pronounced proliferation of amine precursor uptake and decarboxylase activity
      (APUD-type) cells was found in the segmental bronchi and bronchioles of Syrian
      golden hamsters during N-diethylnitrosamine (DEN)-induced lung carcinogenesis.
      Since similar epithelial alterations did not occur in previous experiments after
      benzo(a)pyrene (B(a)P) treatment, it is concluded that the initial stages of lung
      carcinogenesis differ with respect to the carcinogen administered.

PMID- 1016953
TI  - DNA damage and repair in intact animals. Single-stranded regions in rat liver DNA
      following administration of dimethylnitrosamine.
AB  - Rat liver DNA was radioactively labelled by administration of [3H]thymidine
      following partial hepatectomy. Two weeks later, the rats were treated with the
      carcinogen, dimethylnitrosamine. DNA was isolated and fractionated by elution
      from benzoylated DEAE-cellulose with NaCl and caffeine solution. The caffeine
      eluted fraction was increased by administration of dimethylnitrosamine. This
      increase was proportional to the dose of carcinogen injected and persisted for at
      least 24 h after administration of the carcinogen. These data, together with the
      results of hydroxyapatite chromatography, suggest that the DNA contains short
      single-stranded sections associated with much longer regions of native DNA.

PMID- 1016954
TI  - On the carcinogenic polycyclic aromatic hydrocarbon benzo(a)pyrene in volcano
      exhausts.
AB  - The content of benzo(a)pyrene in the juvenile ashes of the volcano Tyatya
      (Kunashir Island, Kuriles) and in the soil, vegetation and volcanic mud collected
      near volcanos in Kamchatka was studied. It was concluded that volcanic activity
      does not play a large role in forming the background level of this carcinogen in
      the human environment.

PMID- 1016955
TI  - Stimulatory effect of staphylococcal leukocidin on granulopoiesis disturbed by
      cytostatic agents.
AB  - Functional tests of granulopoiesis (leukocytosis, bone marrow picture, incubation
      in vitro of bone marrow with [3H]thymidine followed by radioautography and
      counting of labeled promyelocytes and myelocytes, serum muramidase level,
      liberation of granulocyte bone marrow reserve, Nitro-BT reduction in blood
      granulocytes, enzyme cytochemistry, and phagocytosis) were performed in rabbits
      given bubulphan (10 mg/kg) or 5-fluorouracil (200 mg/kg). Determinations were
      carried on serially during treatment with cytostatics. Some of the cytostatic
      treated animals received intravenous (i.v.) injections of purified staphylococcal
      leukocidin in daily doses of 0.1 mg/kg. In control animals, theleukocidin
      resulted in stimulation of granulopoiesis (leukocytosis, increased number of
      [3H]thymidine-labeled myelocytes, elevated serum muramidase level). Animals
      receiving cytostatics suffered from marked inhibition of granulopoiesis
      accompanied by decrease of bone marrow granulocyte reserve. Injection of
      staphylococcal leukocidin during the period of myelosuppression evoked by
      cytostatics resulted in partial protection of granylopoiesis and faster
      regeneration of the leukocyte system.

PMID- 1016956
TI  - Decreased transforming ability of a temperature-sensitive mutant of human
      adenovirus type 12.
AB  - A mutant of human adenovirus type 12, temperature-sensitive for virus replication
      an for the enhancement of thymidine incorporation in resting human embryonic
      kidney cells, is described. The mutant was also temperature-sensitive for
      transformation of rat cells. The results indicate that a viral gene required for
      the virus growth cycle is also required for transformation.

PMID- 1016957
TI  - Random repression, immunological surveillance and hyperthermia.
AB  - A theoretical model of random repression of genetic information in a cancer cell
      is related to the efficiency of the immune system in removing cancer cells. It is
      suggested that at some elevated temperature, binding of a certain repressor
      molecule to the genome ceases and that the cell loses its random properties. We
      conclude with the idea that elevated temperature increases the efficiency of the
      immune system.

PMID- 1016958
TI  - Effect of sodium ascorbate on tumor induction in rats treated with morpholine and
      sodium nitrite, and with nitrosomorpholine.
AB  - Groups of male MRC Wistar rats were treated for 2 years either with morpholine
      (10 g/kg food) together with sodium nitrite (3 g/l drinking water) or with N
      nitrosomorpholine (NM, 0.15g/l drinking water). In both cases, a group of rats
      was given sodium ascorbate (22.7 g/kg food) in addition to these treatments. When
      ascorbate was present, the liver tumors induced by morpholine and nitrite showed
      a 1.7-fold longer induction period, a slightly lower incidence, and an absence of
      metastases in the lungs, indicating that ascorbate had inhibited the in vivo
      formation of NM. Ascorbate did not affect liver tumor induction by the performed
      NM. The group treated with morpholine, nitrite, and ascorbate had a 54% incidence
      of forestomach tumors, including an 18% incidence of squamous cell carcinomas,
      possibly because ascorbate promoted NM action in this organ.

PMID- 1016959
TI  - Skin tumor initiating ability of benzo(a)pyrene 4,5- 7,5- and 7,8-diol-9,10
      epoxides and 7,8-diol.
AB  - The skin tumor initiating abilities of both K-region and non-K-region epoxides of
      benzo(a)pyrene(BP) were determined in mice using a two-stage system of
      tumorigenesis. BP-4,5-epoxide and BP-7,8-dihydrodiol-9,10-epoxide (anti) were
      found to be weak tumor initiators whereas BP-7,8-epoxide had about a third of the
      activity as the parent hydrocarbon, BP. However, the 7,8-dihydrodiol of BP was
      found to be approximately as potent as BP suggesting that it may be a proximate
      carcinogen.

PMID- 1016960
TI  - The effect of withaferin A on human peripheral blood lymphocytes. An electron
      microscope study.
AB  - Cultures of normal human peripheral blood lymphocytes stimulated by
      phytohaemagglutinin (PHA) were treated with withaferin A and examined by an
      electron microscope. The compound was found to affect the spindle microtubules of
      cells in metaphase. There were no intact pole-to-pole microtubules or pole-to
      kinetochore microtubules found in the treated cells; the centrioles were located
      in the center. Furthermore, cells at interphase were also affected, the membrane
      system of the cells being damaged.

PMID- 1016961
TI  - The effect of withaferin A, a natural steroidal lactone, on the fine structure of
      S-180 tumor cells.
AB  - Mouse sarcoma 180 (S-180) solid and ascites tumor cells were treated in vivo and
      in vitro with withaferin A and observed with the electron microscope. The
      compound was found to effect this spindle microtubules of cells in metaphase. An
      interesting finding was the double membranes surrounding the chromosomes in the
      treated cells; probably the nuclei were reconstructed directly from the metaphase
      stage in the in vivo withaferin A-treated cells. In addition the membranes of the
      cells in interphase were affected by in vivo or in vitro treatment with the
      compound.

PMID- 1016962
TI  - Effect of chronic administration of dimethylnitrosamine on the excision of O6
      methylguanine from rat liver DNA.
AB  - Rats were exposed chronically to unlabelled N,N-dimethylnitrosamine (25 ppm in
      the drinking water) then given a single dose of N-[3H]methyl-N-nitrosourea (10
      mg/kg body weight). The rates of loss of tritium-labeled 7-methylguanine, O6
      methylguanine and 3-methyladenine from the liver DNA in control and
      dimethylnitrosamine-treated rats were found not to be significantly different.
      Thus, under the conditions used, inhibition of the O6-methylguanine excision
      repair system does not seem to be a factor in the induction of liver tumours by
      chronic DMN application.

PMID- 1016963
TI  - Induction of renal pelvic tumours in Sprague-Dawley rats by di
      isopropanolnitrosamine.
AB  - Transitional cell papillomas and carcinomas of the renal pelvis were observed in
      Sprague-Dawley rats after subcutaneous (s.c.) treatment with di
      isopropranolnitrosamine (DIPN). These tumours occurred unilaterally and appeared
      as early as 24 weeks after the commencement of treatment. The tumours frequently
      filled the entire renal pelvis and compressed the kidney parenchyma. The
      malignant neoplasms demonstrated infiltrative growth into the adjacent medullary
      parenchyma.

PMID- 1016964
TI  - Echocardiographic evaluation of adriamycin cardiotoxicity in children.
AB  - Thirty children with malignant solid tumors receiving adriamycin had serial
      evaluation of left ventricular (LV) function by echocardiography. The
      echocardiographic studies showed a progressive decrease in myocardial
      contractility as evidenced by changes in several parameters of LV function with
      increasing cumulative doses of the drug. Using the patients as their own
      controls, serial echocardiography appears to be a reliable method for detecting
      early alteration of cardiac function in the asymptomatic patient. This technique
      may prove useful to prevent cardiomyopathy secondary to adriamycin and to prolong
      therapy beyond the currently established limits.

PMID- 1016965
TI  - Studies of the effects of cyclophosphamide, vincristine, and prednisone on some
      hepatic oxidations and conjugations.
AB  - The effects of low and high doses of three anticancer agents, cyclophosphamide,
      vincristine, and prednisone (given individually or in various combinations), on
      oxidative and conjugation pathways were studied in Sprague-Dawley male rats.
      Cyclophosphamide used alone at low doses decreased aniline hydroxylase and
      ethylmorphine demethylase activities by about 20% and at high doses produced a
      30%-50% decrease in the specific activities of several microsomal mixed-function
      oxygenase activities, in the contents of cytochromes P-450 and b5, and in the
      magnitudes of type I and II drug-binding spectrum. The levels of microsomal
      glucouronidase, glucuronyl transferase, and sulfatase per gram of liver were also
      decreased (30%-50%) by the high dose of cyclophosphamide. The high dose of
      cyclophosphamide in conjunction with either vincristine or prednisone also
      produced a noticeable decrease in several activities tested; however, when
      cyclophosphamide was given at either low or high doses in combination with
      vincristine and prednisone, the activities tested were comparable to those seen
      in untreated controls. The mechanism of this protection is presently unknown.
      Vincristine, at both low and high doses, produced little effect on oxidative
      pathways; however, at low doses it caused a significant increase (80%) in the
      specific activity of hepatic microsomal sulfatase. This effect was also
      discernible when vincristine was given in combination with cyclophosphamide and
      prednisone. Other than producing a 15% decrease in liver weight and a 40%
      decrease in the specific activity of microsomal glucuronidase, the high dose of
      prednisone used had no effect on various activities tested. Results of these
      studies indicate a potential for drug interaction among anticancer agents and
      supportive drugs used in combination cancer chemotherapy.

PMID- 1016966
TI  - Survival and cycle-progression delay of human lymphoma cells in vitro exposed to
      VP-16-213.
AB  - The lethal and kinetic effects of VP-16-213 were analyzed in a human lymphoid
      cell line (T1 cells) in vitro. When asynchronous T1 cells were exposed to
      increasing concentrations of VP-16-213 for 1 hour, an exponential survival curve
      with a Do (mean lethal dose equal to the concentration required to reduce
      survival by 63% on the exponential part of the survival curve) of 3 mug/ml was
      obtained. Increasing exposure time also reduced survival exponentially.
      Synchronized cells showed age-dependent sensitivity to VP-16-213 with the
      greatest lethal damage experienced by cells treated in S and G2 phase. The major
      kinetic response of the T1 cells to VP-16-213 was a delay in G2 phase, the extent
      and duration of which was a function of drug concentration, exposure time, and
      cell cycle stage of drug addition; thus, cells in S phase were most effectively
      blocked in the subsequent G2 phase. Continuous treatment with concentrations of
      VP-16-213 (greater than 0.5 mug/ml for greater than 3 hours) caused a retardation
      of S-phase transit with prompt recovery after drug release. Treatment with 10.0
      mug/ml for greater than 3 hours resulted in a "frozen state" of the whole life
      cycle, inducing only minor compartment changes. DNA synthesis was inhibited in
      the majority of cells with an S-phase DNA content. There was no correlation
      between the extent of perturbation and lethal effects after treatment with VP-16
      213.

PMID- 1016967
TI  - Studies with 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride.
      II. Effects on macromolecular synthesis in cell culture and evidence for
      alkylating activity.
AB  - 2,5-Piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride (NSC-135758)
      inhibited DNA synthesis but not RNA and protein synthesis in Adenocarcinoma 755
      cells in culture. The expression of such inhibition was delayed in time; it was
      necessary to expose tumor cells to NSC-135758 for 10-12 hours before measuring
      the macromolecular synthesis in order to demonstrate selective inhibition of DNA
      synthesis. Inhibition of DNA synthesis was demonstrated to be irreversible in
      human epidermoid carcinoma cells in culture. Exposure of cells in suspension
      culture to NSC-135758 or to melphalan for 1-4 hours, and then incubation of cells
      in the absence of an inhibitor for 20 hours, resulted in preferential inhibition
      of DNA synthesis; inhibition of RNA synthesis was observed under these conditions
      but was less pronounced. Chemical evidence for alkylating activity of NSC-135758
      and of the bis-aziridine derived from it (NSC-201424) was obtained by
      demonstrating their reaction with 4-(p-nitrobenzyl)pyridine. NSC-135758 was more
      potent as a cytotoxic agent than was its derivative, a result which suggests that
      NSC-135758 is the active alkylating agent. Reaction of NSC-135758 with
      diethylamine was examined; the product obtained upon alkylation of diethylamine
      by NSC-135758 was identified from its proton magnetic resonance spectrum and by
      field desorption mass spectral analysis. These results support the view that NSC
      135758 acts as an alkylating agent in inhibiting DNA synthesis and cell
      proliferation of tumor cells in culture.

PMID- 1016968
TI  - Studies with 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride.
      III. Biochemical and therapeutic effects in L1210 leukemias sensitive and
      resistant to alkylating agents: comparison with melphalan, cyclophosphamide, and
      BCNU.
AB  - 2,5-Piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride (NSC-135758)
      selectively inhibits DNA synthesis in L1210/0 leukemia and in cyclophosphamide
      resistant L1210 (L1210/CPA). Melphalan (L-PAM) inhibits nucleic-acid synthesis
      but not protein synthesis in L1210/0 and L1210/CPA. CPA selectively inhibits DNA
      synthesis in L1210/0 but does not inhibit DNA synthesis in L1210/CPA. NSC-135758
      is as active in vivo against L1210/CPA and BCNU-resistant L1210 (L1210/BCNU) as
      it is against L1210/0. It is inactive against ic implanted L1210/0. These data
      clearly indicate important differences in the biologic activity of this compound
      compared to either CPA or BCNU. L-PAM is similar to NSC-135758 in activity
      against L1210/CPA and L1210/BCNU.

PMID- 1016969
TI  - Amino acid-conferred resistance to melphalan. I. Structure-activity relationship
      in cultured murine L1210 leukemia cells.
AB  - Melphalan cytotoxicity to murine L1210 leukemia cells in culture was reduced in
      growth medium containing amino acids. Investigation of the effect of single amino
      acids revealed that the L-isomers of glutamine and leucine, but not the D
      isomers, were the most active in decreasing cytotoxicity. Protection was
      concentration dependent, with maximum protection occurring at approximately 0.25
      mM, a physiologic concentration. The LD90 for melphalan in the presence of 0.1 mM
      L-glutamine or L-leucine was increased by 7.3- and 10.8-fold respectively, under
      conditions where the cells had been pre-incubated with the amino acids. These
      results are interpreted to suggest that melphalan transport by the L1210 leukemia
      cell is mediated by a system also responsible for the transport of glutamine and
      leucine and that interaction with such a system may play a significant role in
      the chemotherapeutic activity of this alkylating agent.

PMID- 1016970
TI  - Combination chemotherapy with mitomycin C, 5-fluorouracil, and cytosine
      arabinoside in gastrointestinal cancer.

PMID- 1016971
TI  - Comparison of the biologic activity of VP-16-213 given iv and orally in capsules
      or drink ampules.

PMID- 1016972
TI  - Combination cytotoxic chemotherapy for metastatic cutaneous malignant melanoma
      with DTIC, BCNU, and vincristine.

PMID- 1016973
TI  - Phase II study of ICRF-159 in patients with metastatic colorectal carcinoma
      previously exposed to systemic chemotherapy.

PMID- 1016974
TI  - Combination therapy with mitomycin C,5-fluorouracil, and cytosine arabinoside in
      P815 ascites and solid mouse neoplasms.

PMID- 1016975
TI  - Pigmentation of the tongue after treatment with adriamycin.

PMID- 1016976
TI  - Antiestrogens in the treatment of breast cancer.

PMID- 1016977
TI  - Prostaglandins and cancer.

PMID- 1016978
TI  - Radiosensitizers of hypoxic cells in solid tumors.

PMID- 1016979
TI  - Enol acetates of nucleoside-5'-aldehydes: potential intermediates for substituent
      incorporation at C-4'.

PMID- 1016980
TI  - Utilization of unsaturated amino sugars in the synthesis of nucleosides.

PMID- 1016981
TI  - Synthesis of 2-acetamido-2-deoxy-3-O-beta-D-mannopyranosyl-D-glucose.
AB  - Condensation of 4,6-di-O-acetyl-2,3-O-carbonyl-alpha-D-mannopyranosyl bromide
      with benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-alpha-D-glucopyranoside (2)
      gave an alpha-D-linked disaccharide, further transformed by removal of the
      carbonyl and benzylidene groups and acetylation into the previously reported
      benzyl 2-acetamido-4,6-O-benzylidene groups and acetylation into the previously
      reported benzyl 2-acetamido-4,6-O-benzylidene-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl
      alpha-D-mannopyranosyl)-alpha-D-glucopyranoside. Condensation of 3,4,6-tri-O
      benzyl-1,2,-O-(l-ethoxyethylidene)-alpha-D-glucopyranose or 2-O-acetyl-3,4,6-tri
      O-benzyl-alpha-D-glucopyranosyl bromide with 2 gave benzyl 2-acetamido-3-O-(2 O
      acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranosyl)-4,6-O-benzylidene-2-deoxy-alpha
      D-glucopyranoside. Removal of the acetyl group at O-2, followed by oxidation with
      acetic anhydride-dimethyl sulfoxide, gave the beta-D-arabino-hexosid-2-ulose 14.
      Reduction with sodium borohydride, and removal of the protective groups, gave 2
      acetamido-2-deoxy-3-O-beta-D-mannopyranosyl-D-glucose, which was characterized as
      the heptaacetate. The anomeric configuration of the glycosidic linkage was
      ascertained by comparison with the alpha-D-linked analog.

PMID- 1016982
TI  - The synthesis of 2-acetamido-2-deoxy-4-O-beta-D-mannopyranosyl-D-glucose.
AB  - Condensation of 4,6-di-O-acetyl-2,3-O-carbonyl-alpha-D-mannopyranosyl bromide
      with 2-amino-2-N,3-O-carbonyl-5.6-O-isopropylidene-D-glucose diethyl acetal gave,
      unexpectedly, 2-amino-2-N,3-O-carbonyl-2-deoxy-4-O-(4,6-di-O-acetyl-2,3-O
      carbonyl-alpha-D-mannopyranosyl)-5,6-O-isopropylidene-D-glucose diethyl acetal,
      futher transformed, by de-esterification followed by acetylation, into the
      previously known 2-amino-2-N,3-O-carbonyl-2-deoxy-5,6-O-isopropylidene-4-O-alpha
      D-mannopyranosyl-D-glucose diethyl acetal and its tetra-O-acetyl derivative.
      Benzyl 2-acetamido-3,6-di-O-benzyl-2-deoxy-beta-D-glucopyranoside was condensed
      with 2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranosyl bromide to give benzyl 2
      acetamido-4-O-(2-O-acetyl-3,4,6-tri-O-benzyl-beta-D-glucopyranosyl)-3,6-di-O
      benzyl-2-deoxy-beta-D-glucopyranoside. Removal of the 2-O-acetyl group, followed
      by oxidation with acetic anhydridedimethyl sulfoxide, gave a beta-D-arabino
      hexosid-2-ulose (25). After reduction with sodium borohydride, removal of the
      benzyl groups gave crystalline 2-acetamido-2-deoxy-4-O-beta-D-mannopyranosyl-D
      glucose (27). The anomeric configuration of the glycosidic linkage was
      ascertained by comparison with the alpha-D-linked disaccharide.

PMID- 1016983
TI  - The synthesis, binding, and agglutinating activity of 6-aminohexyl beta-D
      mannopyranoside.

PMID- 1016984
TI  - Synthesis of prumycin and related compounds.
AB  - Prumycin (1) and related compounds have been synthesized from benzyl 2
      (benzyloxycarbonyl)amino-2-deoxy-5,6-O-isopropylidene-beta-D-glucofuranoside (4).
      Benzoylation of 4, followed by deisopropylidenation, gave benzyl 3-O-benzoyl-2
      (benzyloxycarbonyl)amino-2-deoxy-beta-D-glucofuranoside (6), which was converted,
      via oxidative cleavage at C-5-C-6 and subsequent reduction, into the related
      benzyl beta-D-xylofuranoside derivative (7). Benzylation of 3-O-benzoyl-2
      (benzyloxycarbonyl)-amino-2-deoxy-D-xylopyranose (8), derived from 7 by
      hydrolysis, afforded the corresponding DERIVATIVES (9,11) of beta-and alpha-D
      xylopyranoside, and compound 7 as a minor product. Treatment of benzyl 3-O
      benzoyl-2(benzyloxycarbonyl)amino-2-deoxy-4-O-mesyl-beta-D-xylopyranoside (10),
      formed by mesylation of 9, with sodium azide in N,N-dimethylformamide gave benzyl
      4-azido-3-O-benzoyl-2-(benzyloxycarbonyl)amino-2,4-dideoxy-alpha-L
      arabinopyranoside (13), which was debenzoylated to compound 14. Selective
      reduction of the azide group in 14, and condensation of the 4-amine with N-[N
      benzyloxycarbonyl)-D-alaninoyloxy]succinimide, gave the corresponding derivative
      (15) of 1. Reductive removal of the protecting groups of 15 afforded 1. Prumycin
      analogs were also synthesized from compound 14. Evidence in support of the
      structures assigned to the new derivatives is presented.

PMID- 1016985
TI  - Methylation studies of the polysaccharides resulting from sequential Smith
      degradations of the galactan from the snail Strophocheilus oblongus.
AB  - When the galactan from the albumen glands of the snail Strophocheilus oblongus
      was submitted to three Smith-degradation, the degraded polysaccharide, isolated
      in 6% yield, was much more linear. Methylation analysis showed that the Smith
      degraded polysaccharide gave an increased percentage of 2,4,6-tri, decreased
      percentages of 2,3,4,6-tetra-and 2,4-di, and a large variation in the amount of
      2,3,4-tri-O-methyl-D-galactose. The sugars in the polysaccharide which result in
      the formation of 2,3,4,6-tetra- and 2,3,4-tri-O-methyl-D-galactose are destoryed
      in subsequent degradation procedures. The above observations suggest that the
      degradation by periodate oxidation proceeds via non-reducing end-groups and
      though some internal residues that are exposed as the degradation proceeds. As a
      result of the overall process, new non-reducing end-groups are formed and new (1
      leads to 6)-linked D-galactose residues are then exposed. The  isolation of
      glycosides of low molecular weight supports the suggestion that the molecule, in
      the main, is sequentially degraded from the external layers.

PMID- 1016986
TI  - Synthesis of O-beta-D-galactopyranosyl-(1 linked to 4)-O-(2acetamido-2-deoxy-beta
      D-glucopyranosyl)-(1 linked to 2)-D-mannose and its interaction with various
      lectins.
AB  - 2-Methyl-[3,6-di-O-acetyl-2-deoxy-4-O-(2,3,4,6-tetra-O-acetyl-beta-D
      galactopyranosyl)-alpha D-glucopyrano]-[2,1-d]-2oxazoline (4) was prepared from 2
      acetamido-3,6-di-O-acetyl-2-deoxy-4-O-(2,3,4,6-tetra-O-acetyl-beta-D
      galactopyranosyl)-alpha-D-glucopyranosyl chloride. Condensation of 3,4:5,6-di-O
      isopropylidene-D-mannose dimethyl acetal with 4 in the presence of a catalytic
      amount of p-toluenesulfonic acid afforded O-(2,3,4,6-tetra-O-acetyl-beta-D
      galactopyranosyl)-(1 linked to 4)-O-(2-acetamido-3,6-di-O-acetyl-2-deoxy-beta-D
      glucopyranosyl)-(1 linked to 2)-3,4:5,6-di-O-ispropylidene-D-mannose dimethyl
      acetal (6) in 8.6% yield. Catalytic deacetylation of 6 with sodium methoxide,
      followed by hydrolysis with dilute sulfuric acid, gave O-beta-D-galactopyranosyl
      (1 linked to 4)-O-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-(1 linked to 2)-D
      mannose (7). The inhibitory activities of 7 and related sugars against the
      henagglutinating activities of various lectins were assayed, and 7 was found to
      be a good inhibitor against Phaseolus vulgaris hemagglutinin.

PMID- 1016987
TI  - Chemical modification of aminocyclitol antibiotics.
AB  - The aminocyclitol antibiotic neamine has been chemically modified at the hydroxyl
      group on C-6 of the 2-deoxystrepatamine moiety. The partially acetylated neamine
      derivatives, 6,3,4-tri-O-acetyl- (3) and 5,3-57,4-tri-O-acetyl-1,3,2,6-tetra-N
      (ethoxycarbonyl)neamine (4), were prepared by random hydrolysis of the 5,6-O
      ethoxyethylidene derivative (2), followed by chromatographic purification.
      Condensation of 4 and 2,3,5-tri-O-benzoyl-D-ribofuranosyl chloride led to 6-O
      (beta-D-ribonfuranosyl)neamine (7). Analogous condensation of 4 with 2,3,4,6
      tetra-O-acetyl-alpha-D-glucopyranosyl bromide or 2,3,4,6-tetra-O-acetyl-alpha-D
      galactopyranosyl bromide afforded the corresponding 6-O-(D
      hexopyranosyl)neamines.

PMID- 1016988
TI  - Changes in carbohydrate content of surface membranes of human erythrocytes during
      ageing.
AB  - The carbohydrate content (neutral hexoses, fucose, sialic acid, and hexosamine)
      of human erythrocytes is significantly higher in young than in old erythrocytes.
      The differences observed in the carbohydrate content of surface glycopeptides,
      obtained after incubation with either Pronase or trypsin, is still more striking,
      suggesting important modifications of the carbohydrate moeties of the erythrocyte
      membrane during in vivo ageing.

PMID- 1016989
TI  - Studies of the epimerization of 2-acetamido-2-deoxy-D-glucopyranose:selective
      deuteration at C-2 of 2-acetamido-2-deoxyaldoses.

PMID- 1016990
TI  - Synthesis of O-beta-D-glucopyranosyl-(1 linked to 3)-O-alpha-L-fucopyranosyl-L
      threonine.

PMID- 1016991
TI  - The synthesis of N-(benzyloxycarbonyl)-3-O-E13,4,6-tri-O-acetyl-2-deoxy-2-(2,4
      dinitroanilino)-beta-D-glucopyranosyl]-L-serine methyl ester, and its
      condensation with activated esters of amino acids.

PMID- 1016992
TI  - Isolation of 3-O-methyl-D-ribose from a Rhizobium polysaccharide.

PMID- 1016993
TI  - Venous pressure and exercise tolerance.
AB  - Compared to the number of contractions obtained when a blood pressure cuff on the
      upper arm was at zero pressure, inflation of the cuff to pressures ranging
      between 5 and 40 mm Hg resulted in an augmentation of the number of hand
      contractions that could be performed prior to the development of ipsilateral
      severe fatigue or intolerable pain. Cuff pressures of 60 mm Hg reduced the number
      of contractions below the control level. These results are consistent with the
      concept that exercise during venous congestion facilitates the washout of the
      toxic catabolite presumed to be produced during muscular contraction.

PMID- 1016994
TI  - Factors affecting the transvalvar pressure difference in a hydraulic model of
      aortic stenosis.
AB  - Mechanical factors that can modify the peak transvalvar pressure differences
      (delta P) in aortic stenosis were evaluated in a model. A latex rubber sac
      simulated the ventricle. Expansion of the walls of the sac by means of a negative
      pressure applied to its outer wall introduced a measure volume into the sac and
      placed the wall materials under tension. The stretched sac was then permitted to
      contract and to expel its contents through "aortic valvar" orifices of various
      severities of stenosis, into an aortic standpipe of selected diameters
      (compliances). Factors that increased the peak delta P included the strength
      (thickness) of the ventricular wall, the rate at which it mobilized and applied
      its tensile force to compress the sac contents, the unstressed volume of the sac,
      the total volume in the sac at onset of contraction, the severity of the valvar
      stenosis, the compliance of the aorta, the rate of arterial run-off, and the
      aortic diastolic pressure. Loss of forward stroke volume due to mitral
      regurgitation lowered the peak delta P. Elevations in diastolic arterial pressure
      also lowered delta P. All of these mechanical factors should be considered in the
      analysis of the severity of clinical aortic valvar stenosis and in decisions for
      medical therapy and surgical correction. The several factors which do not depend
      directly on the orifice area or on the forward stroke volume vitiate the sole use
      of the orifice formula in the analysis of the dynamics of aortic stenosis. The
      application of this approach in related problems is indicated.

PMID- 1016995
TI  - Effect of ischemia and infarction on regional content of adenine nucleotides and
      derivatives in canine left ventricle.
AB  - Samples of myocardium from four areas of ischemic and infarcted canine ventricle
      were examined over a 20-day period for content of the three adenine nucleotides
      as well as inosine, hypoxanthine, adenosine, and inosine monophosphate. The
      adenosine triphosphate (ATP) content of central and peripheral areas within the
      infarct fell to 11% and 8% of control, respectively, 1 day after coronary
      occlusion. The total adenine nucleotide (TAN) content in these areas fell to 17%
      of control and showed no significant recovery during the period of study. In the
      functional myocardium immediately surrounding the infarct the ATP content was
      depressed to 58% control after 1 day, and the TAN content was also depressed. In
      the healthy myocardium near the apex, the ATP content was significantly depressed
      only at the 3-day sample period. Adenine nucleotide derivatives were detected
      only at 30 min in the central ischemic area. The absence of the nucleoside and
      nucleobase compounds formed during adenine nucleotide degradation is attributed
      to their high membrane diffusibility. Loss of these compounds is considered a
      contributing factor in the prolonged depression of adenine nucleotide content in
      both ischemic and non-ischemic regions.

PMID- 1016996
TI  - Massive left atrial thrombus: a case report.
AB  - This case report describes a patient with aortic and mitral valvular disease who
      had a massive left atrial thrombus. The left atrial thrombus produced a
      disappearance of signs of mitral stenosis and a reversed pan diastolic mitral
      valve gradient. This gradient occurred in the absence of any diastolic mitral
      insufficiency and may have been due to artifactual lowering of the left atrial
      pressure by an organized left atrial clot.

PMID- 1016997
TI  - Pericarditis associated to acquired toxoplasmosis in a child.

PMID- 1016998
TI  - [Angina with the elevation of the S-T tract. Variant angina or no?].

PMID- 1016999
TI  - [Alcoholic heart disease : precocious insufficiency of myocardial contractility].

PMID- 1017000
TI  - [Surgical treatment of high-risk coronary disease].

PMID- 1017001
TI  - [Prognostic significance of the appearance of hemiblock during acute myocardial
      infarct].

PMID- 1017002
TI  - [Acute idiopathic pericarditis and pleuropericarditis : clinical, etiological and
      epidemiological studies in the period from 1969 to 1974].

PMID- 1017003
TI  - [The Wedensky effect].

PMID- 1017004
TI  - Central commitee of the Czech Medical Society.

PMID- 1017005
TI  - [Ultrasonic assessment of changes occurring in the hemodynamics of carotid and
      vertebral circulation (author's transl)].

PMID- 1017006
TI  - [Effects of propranolol on plasma lipids and renin activity in young men with
      labile borderline hypertension (author's transl)].

PMID- 1017007
TI  - [Magnesemia in patients with renal insufficiency in the period of time proceding
      the hemodialysis therapy (author's transl)].

PMID- 1017008
TI  - [On the problem of calcium concentration in water and in the dialysate in Czech
      hemodialysis centres (author's transl)].

PMID- 1017009
TI  - [Herpes virus hominis type 1 and mental diseases (author's transl)].

PMID- 1017010
TI  - Capping of eucaryotic mRNAs.

PMID- 1017011
TI  - Selection of temperature-sensitive CHL asparagyl-tRNA synthetase mutants using
      the toxic lysine analog, S-2-aminoethyl-L-cysteine.
AB  - We developed a procedure, using the toxic lysine analog S-2-aminoethyl-L-cysteine
      (thialysine) as the selective agent, to obtain mutant Chinese hamster lung (CHL)
      fibroblasts with temperature-sensitive defects affecting protein synthesis. The
      procedure is efficient, rapid, and simple. Using this selective system, we
      isolated six temperature-sensitive mutants that fail to grow (plating
      efficiencies less than 10-5) and synthesize protein at 39 degrees C. The
      temperature-sensitive phenotype of five of the six mutants is suppressed in vivo
      by exogenous asparagine. In the mutant studied in the greatest detail, asparagyl
      tRNA synthetase activity is extremely thermolabile in vitro. Asparagine
      suppressible, temperature-sensitive mutants are induced at a high frequency by
      the mutagen ethylmethane sulfonate (EMS), and they can be efficiently recovered
      using the proper selective conditions. Our results suggest that CHL cells have
      only one functional copy of the gene encoding for asparagyl-tRNA synthetase.

PMID- 1017012
TI  - Control of lysozyme induction in the differentiation of myeloid leukemic cells.
AB  - A system has been developed with clones of mouse myeloid leukemic cells in
      culture to study the induction of synthesis and secretion of lysozyme in relation
      to other steps in myeloid cell differentiation. Lysozyme was initially absent in
      all the clones studied. The different clones can be divided into three types
      according to their ability to be induced to undergo normal cell differentiation
      by the protein inducer MGI (macrophage and granulocyte inducer). One type of
      clone that can be induced by MGI to form Fc and C3 receptors and differentiate to
      mature macrophages and granulocytes (MGI+D+) was also induced by MGI to
      synthesize and secrete lysozyme. Lysozyme was induced after Fc and C3 receptors,
      and labeling with 35S-methionine has shown that the induced lysozyme was newly
      synthesized. MGI+D+ clones were also induced to synthesize and secrete lysozyme
      by dexamethasone, prednisolone, cytosine arabinoside, or thymidine and in one of
      four clones by dimethylsulfoxide but not by sodium butyrate. Inhibition of cell
      multiplication by itself was not sufficient to induce lysozyme synthesis. A
      second type of clone which can be induced by MGI to form Fc and C3 receptors but
      not mature cells (MGI+D-) was more weakly inducible by MGI for lysozyme and was
      not inducible by any of the other compounds. A third type of clone (MGI-D) MGI
      for receptors or mature cells. One of four MGI-D- clones was induced to
      synthesize but not secrete lysozyme by dexamethasone together with sodium
      butyrate, but there was no lysozyme induction by MGI or any of the other
      compounds separately. The different clones maintained their different properties
      for at least 6 months in culture. The results indicate that clones with different
      hereditary blocks in the ability to be induced to differentiate by specific
      compounds can be used to dissect the process of myeloid cell differentiation,
      that the sequence of differentiation is induction of Fc and C3 receptors leads to
      lysozyme leads to mature cells, and that there are separate controls for these
      developmental steps.

PMID- 1017013
TI  - The expression of three abundance classes of messenger RNA in mouse tissues.
AB  - Using the technique of mRNA-cDNA hybridization, we have shown that there are
      between 11,500 and 12,500 different mRNAs in three different mouse
      tissues:kidneys, brains, and livers. Several experiments suggest that in each
      tissue the mRNAs are organized into three abundance classes rather than as a
      continumm with respect to concentration. Cross-hybridization experminets show
      that the most abundant class of mRNA in each tissue is characteristic, and that a
      high proportion of the total sequences are common between tissues. For a more
      complete analysis, cDNA was fractionated into three classes. Studies using
      isolated abundant cDNA show that some abundant sequences of liver and kidney are
      present in other tissues, but among the lower frequency classes. Thus tissue
      specific differences in mRNA populations may be related to abundance as well as
      qualitative differences. Using isolated middle frequency cDNA of the kidney, it
      was shown that of the 550 or so sequences in this class, approximately 500 are
      shared with the liver. Similarly, between 9,500 and 10,500 of the low frequency
      kidney cDNAs are shared with the brain and liver, respectively, suggesting that
      the majority of mRNAs may be involved with "housekeeping" activities. In an
      attempt to see whether abundance of mRNA is related to repetition of the sequence
      in the genome, it was shown that abundant and middle frequency cDNA of the liver
      and kidney contain a component that anneals with DNA repeated approximately 100
      fold. However, the low frequency cDNA of the kidney contains no repeated
      sequences.

PMID- 1017014
TI  - A radiological analysis of the transcription units for heterogeneous nuclear RNA
      in cultured murine cells.
AB  - Ultraviolet irradiation of cultured murine cells damages chromosomal DNA, thus
      causing premature termination of synthesis of hnRNA chains. We have utilized this
      effect for measuring the sizes of transcription units for the various classes of
      hnRNA. Target size analyses of the loss of synthesis of hnRNA species suggest
      that hnRNA, through its entire size range, constitutes mostly primary transcripts
      that is, the shorter RNA molecules are not processed from longer precursors.
      Polyadenylated hnRNA appears to be a primary transcript as well. Our data,
      however, are also consistent with processing of precursors to poly(A)+ hnRNA from
      the 5'termini of larger hnRNA molecules. They are not consistent with models
      which postulate that poly(A)+ hnRNA sequences originate at the 3' termini of
      precursors which are considerably larger (greater than 30%) than the
      polyadenylated hnRNA molecules themselves. Finally, we have found that the
      process of polyadenylation is not measurably affected by ultraviolet irradiation
      of cells.

PMID- 1017015
TI  - Identification and characterization of multiple forms of actin.
AB  - Multiple forms of actin have been found in a variety of mammalian cell lines and
      tissues by the use of high resolution, two-dimensional gel electrophoresis. One
      form (alpha actin) was found only in differentiated muscle cells, and its
      synthesis is induced during myogenesis in culture. Two other forms (beta and
      gamma actin) are present in all nonmuscle cell types examined, and they continue
      to be synthesized in cultured muscle cells after fusion. Tryptic peptide
      comparisons have shown that muscle actin is distinguished from the two
      "nonmuscle" actins by several peptide differences, and that the two non-muscle
      actins are nearly identical. All three forms contain equimolar amounts of N
      methylhistidine, and extensive controls have shown no evidence of artifactual
      heterogeneity. In addition to the three major actins, two other proteins were
      identified as probably forms of actin by affinity for DNAase I-agarose. These
      proteins are similar in charge and molecular weight to the major actin forms, but
      are unstable and have lifetimes in the cell of less than 2 hr.

PMID- 1017016
TI  - The effect of ecdysterone on nonhistone proteins in salivary gland chromosomes of
      Sciara coprophila.
AB  - Synthesis and transport of proteins to the cell nucleus during puff induction was
      studied in S. coprophila. Changes in grain distribution along chromosomes (L
      methionine [35S] incorporation into protein) were correlated with puffs induced
      by ecdysterone in vitro; A pattern of specific labelling at the sites of
      incipient puffs was noted within 2 h after the addition of the hormone, i.e.
      grains on the chromosomes were in clusters, characteristic for this time point
      and not seen in the controls (where only non-specific labeling was noted 0-4 h).
      Characteristic chromosomal puffs appeared between 3-4 h after the addition of
      ecdysterone. It was concluded that during ecdysterone-induced puff formation in
      salivary gland chromosomes, proteins which had been previously synthesized were
      selectively transported from the cytoplasm to specific sites on the chromosomes.

PMID- 1017017
TI  - Changes in type of collagen synthesized by chick fibroblasts in vitro in the
      presence of 5-bromodeoxyuridine.
AB  - Chick embryo fibroblasts cease to synthesize their normal collagen product when
      grown in the presence of the thymidine analogue, 5-bromodeoxyuridine (BrdU). The
      drug causes an alteration of synthesis from the normal Type I collagen (alpha1
      (I)2alpha2) to a mixture of Type I and Type I trimer (alpha1(I)3). While the
      significance of the synthesis of Type I trimer is unclear, it has been noted that
      chondrocytes synthesize this collagen type following in vitro senescence and in
      the presence of BrdU. Since BrdU may cause a switching in the temporal pattern of
      collagen biosynthesis in chondrocytes and in fibroblasts it is proposed that BrdU
      may alter the normal regulatory controls acquired by the cells during the course
      of their differentiation. The synthesis of type I trimer might provide a marker
      for such a break-down in a wide variety of cell types.

PMID- 1017018
TI  - Recombination of embryonic haemoglobin chains during the development of the
      chick.
AB  - Embryonic differentiation is at present interpreted as the expression of variable
      gene activity. It is commonly thought that derepression of operator gene groups
      is the main cause of progress during development. However it is equally possible
      that gene repression plays a role in the appearance of new phenotypic
      characteristics. This paper illustrates such a possibility. It is known that in
      chickens embryonic haemoglobins exist which are replaced by other haemoglobins at
      about the sixth day of incubation. Analyses of globin chain composition of these
      haemoglobins by chromatography and urea/starch gel electrophoresis as well as TLC
      fingerprinting and amino acid analyses of the individual globin chains showed
      that the haemoglobin switch was not associated with appearance of new globin
      chains but rather with disappearance of a number of embryonic chains. Moreover
      the relative proportion of the various chains changed at that time. From these
      findings we conclude that new haemoglobins arise from a recombination
      ('hybridization in vivo') of those globin chains which remain after the
      repression of a gene coding for embryonic chains.

PMID- 1017019
TI  - Evidence of hormonal control of the nucleolar activity in Sciara ocellaris.
AB  - The nucleolus organizing region in the salivary gland of Sciara ocellaris becomes
      gradually less active as the larvae approach pupation. The cytological visible
      condensation of the nucleolar puff is paralleled by a decrease in the
      incorporation of [3H]-uridine into the ribosomal RNA. Alterations in the
      nucleolar behavior were brought about by extirpation of the neuroendocrine glands
      at six stages of development. There is a 'critical stage' during the 7th day of
      the 4th instar when the hormonal stimulus for pupation occurs. If the ligature is
      performed before this stage the NOR remains expanded and the larval-pupal ecdysis
      is inhibited; if done later on the NOR condenses at a normal rate and the ligated
      larvae mount to head-less pupae. These results suggest that inhibition of rRNA
      synthesis and consequent condensation of the NOR is under the control of the
      moulting hormone.

PMID- 1017020
TI  - [Studies on tablets. XIII. Determination of the scope of permanent deformation
      induced by changes in the apparent density of tablets].

PMID- 1017021
TI  - [Studies on tablets. XXIV. Influence of the speed of compression and of various
      other factors in the condensation of powdered materials].

PMID- 1017022
TI  - [Derivatives of laurophenone. I. Quaternal ammonium and pyridine salts with the
      laurophenone skeleton and their antimicrobial effects].

PMID- 1017023
TI  - [Progress in drug technology in 1974 and 1975].

PMID- 1017024
TI  - [Methods for the determination of vitamin D and its hydroxyderivatives].

PMID- 1017025
TI  - [Primary sclerosing cholangitis].

PMID- 1017026
TI  - [Contribution to the regional incidence of chronic calcifying pancreatitis
      (author's transl)].

PMID- 1017027
TI  - [Changes of vegetative reflexes and the cold test in patients with peptic ulcers
      and healthy subjects (author's transl)].

PMID- 1017028
TI  - [Vitamin C and vigilance (author's transl)].

PMID- 1017029
TI  - [Endoscopic diagnosis of duodenal neoplasms].

PMID- 1017030
TI  - [Transumbilical portomanometry].

PMID- 1017031
TI  - [Polypous angiomatosis of the rectum (author's transl)].

PMID- 1017032
TI  - [Remedial exercise of some diseases of the digestive tract (author's transl)].

PMID- 1017033
TI  - [Some new findings pertaining to coeliac sprue in adults (author's transl)].

PMID- 1017034
TI  - [The development of cerebrospinal fluid in chick embryo].

PMID- 1017035
TI  - [Electrophysiological manifestations of the development of interhemispheric
      connections in the rat cerebral cortex].

PMID- 1017036
TI  - [Mathematical modeling of intra- and extracellular potentials in active neurons].

PMID- 1017037
TI  - [Comparison of various methods for the administration of Czechoslovak 14C dextran
      to normovolemic mice].

PMID- 1017038
TI  - [Penetration of 22NaCl, 22NaCl, 86RbCl and 86RbOH through the cornea into the
      aqueous humor of the rabbit eye].

PMID- 1017039
TI  - [Significance of serum cholinesterase determination in patients with glaucoma].

PMID- 1017040
TI  - [Thermography and ultrasonography in ophthalmology].

PMID- 1017041
TI  - [Use of aloe extracts in the treatment of experimental corneal ulcers].

PMID- 1017042
TI  - [Relation of the color of the iris to the pigmentation and width of the anterior-
      chamber angle in patients with primary glaucoma].

PMID- 1017043
TI  - [Retinal fluoroangiographic findings after long-term exposure to carbon sulfide].

PMID- 1017044
TI  - [Surgery of cataract in patients with trachoma].

PMID- 1017045
TI  - [Treatment of central retinal venous occlusion using Rheodextran Spofa].

PMID- 1017046
TI  - [Determination of the need for strabological hospital beds using the Monte Carlo
      method].

PMID- 1017047
TI  - [The etiology and therapy of febrile convulsive attacks in the infant age].

PMID- 1017048
TI  - [Etiopathogenesis and prognosis of febrile convulsions].

PMID- 1017049
TI  - [Prognosis of febrile convulsions].

PMID- 1017050
TI  - [Problems in the preventive treatment of repeated febrile convulsions].

PMID- 1017051
TI  - [Thymus hyperplasia in childhood and its x-ray picture].

PMID- 1017052
TI  - [Respiratory functions and their changes in children living in an area with
      increased air pollution and in a control area].

PMID- 1017053
TI  - [Isolation of Tahyna virus from the blood of sick children].

PMID- 1017054
TI  - [HBs antigen findings in mothers and children].

PMID- 1017055
TI  - [Changes of heart rate and heart conductivity in the course of corrective heart
      surgery in infants and youngest children].

PMID- 1017056
TI  - [Double kidney in x-ray diagnosis].

PMID- 1017057
TI  - [Family environment in intersexual persons].

PMID- 1017058
TI  - [Long-term study on the development of the disease in myositis ossificans
      progressiva].

PMID- 1017059
TI  - [Vertebrogenic headaches in childhood].

PMID- 1017060
TI  - [Vitamin D and rachitis].

PMID- 1017061
TI  - [Incidence of epilepsy among patients of Social Welfare Institutes in the North
      Bohemian Region].

PMID- 1017062
TI  - [Experience with infusion pumps at the ward for premature children].

PMID- 1017063
TI  - [Affection of kidneys in unusual genetic diseases].

PMID- 1017064
TI  - [Importance of cytogenetics in the determination of genetic prognosis in families
      with an isolated incidence of various unusual chromosome aberrations].

PMID- 1017065
TI  - [Incidence of trisomy 13 and 18 in the material of the cytogenetic laboratory in
      1965-1975].

PMID- 1017066
TI  - [Pulmonary function in patients with recurrent bronchititis beginning in
      childhood].

PMID- 1017067
TI  - [Vaccination of children with impaired health using the ADTP (Diphtheria,
      Tetanus, Pertussis) vaccine].

PMID- 1017068
TI  - [Relationship between the levels of calcium, magnesium, anorganic phosphorus,
      citric acid and total proteins in the blood serum of the mother and fetus during
      labor].

PMID- 1017069
TI  - [Ratio of the width of the cranium and the face and the diagnosis of
      craniostenosis].

PMID- 1017070
TI  - [Nosocomial epidemics due to Salmonella bareilly at a newborn infant department].

PMID- 1017071
TI  - [Study on the incidence of rachitis in the children population of the Martin
      district and the relationship of vitamin D to early deformities of the thorax].

PMID- 1017072
TI  - [A-V block of the 2nd degree Wenckebach A-V block in a 17-months-old child].

PMID- 1017073
TI  - [Significance of the correction of leg-length inequality in children].

PMID- 1017074
TI  - [Analysis of the causes of repeated hospitalizations of up-to-2-year-old children
      at the 2nd Pediatric Clinic of the Medical School in Bratislava during 1974
      1975].

PMID- 1017075
TI  - Isolation of an acute hypotensive substance from bovine brain lipid fraction.

PMID- 1017076
TI  - Azabicycloalkanes as analgetics. IV. 4-Phenyl-2-azabicyclo[2,2,1]heptanes.

PMID- 1017077
TI  - The structures of toxic metabolites of Aspergillus candidus. II. The compound B
      (xanthoascin), a hepato- and cardio-toxic xanthocillin analog.

PMID- 1017078
TI  - A comparison of 19-iodocholesterol-131I with 6beta-iodomethyl-19-norcholest-5(10)
      en-3beta-ol-131I as an adrenal-scanning agent.

PMID- 1017079
TI  - Autoradiographic studies on the distribution of quaternary ammonium compounds.
      IV. Adsorption of bisonium ions to rat tissues as revealed by in vitro whole-body
      adsorption autoradiography.

PMID- 1017080
TI  - Further investigations of the effect of riboflavine photolysates on the
      intestinal absorption of certain drugs in rats and their mechanisms of action.

PMID- 1017081
TI  - Fluorometric determination of cephalexin in urine.

PMID- 1017082
TI  - Constituents from seeds of Alpinia galanga Wild, and their anti-ulcer activities.

PMID- 1017083
TI  - Mechanism of the inhibitory effect of polysorbate 80 on intramuscular absorption
      of drugs.

PMID- 1017084
TI  - Purification and characterization of hypocalcemic protein from porcine parotid
      gland.

PMID- 1017085
TI  - Effect of ginseng saponins on nuclear ribonucleic acid (RNA) metabolism. I. RNA
      synthesis in rats treated with ginsenosides.

PMID- 1017086
TI  - Antitumor effect of bisbenzylisoquinoline alkaloids.

PMID- 1017087
TI  - Biosynthesis of streptothricin antibiotics. II. Catabolite inhibition of glucose
      on racemomycin-A production.

PMID- 1017088
TI  - Synthesis of 4-d1-testosterone and 4-d1-androstenedione.

PMID- 1017089
TI  - Studies on the syntheses of heterocyclic compounds. DCLXXI. An alternative total
      synthesis of yohimbine.

PMID- 1017090
TI  - Intestinal absorption of drugs from solubilized systems of long-chain fatty acids
      in the rat.

PMID- 1017091
TI  - Quantitative analysis of the isomers of hydroxyphenylalanine by ion-exchange
      chromatography.

PMID- 1017092
TI  - Studies on prostaglandins. II. Synthesis of 4-alkoxymethyl-2-norbornen-5-one and
      its oxidation reaction with m-chloroperbenzoic acid.

PMID- 1017093
TI  - Studies on the syntheses of analgesics. XLI Optical resolution of (+/-)-N
      cyclopropylmethyl-3-hydroxy-9-azamorphinan (studies on the syntheses of
      heterocyclic compounds. Part DCLXIX).

PMID- 1017094
TI  - Studies on prostaglandins. I. The resolution of dl-(2-beta-benzyloxymethyl-3alpha
      hydroxy-4-cyclopenten-1alpha-yl)acetic acid using L-arginine).

PMID- 1017095
TI  - Mass fragmentographic determination of d- and l-chloropheniramine with aid of the
      stable isotope technique.

PMID- 1017096
TI  - Antitumor polysaccharide fraction from the culture filtrate of Fomes fomentarius.

PMID- 1017097
TI  - Dissolution of slightly soluble drugs. II. Effect of particle size on dissolution
      behavior in sodium lauryl sulfate solutions.

PMID- 1017098
TI  - The particle size evaluation of parenteral suspensions of chloramphenicol and
      correlation of particle size to plasma levels.

PMID- 1017099
TI  - Studies on microcapsules. XIX. Effect of phospholipid treatment on cation uptake
      by carboxylated polyphthalamide microcapsules.

PMID- 1017100
TI  - Synthesis of aristeromycin analogs.

PMID- 1017101
TI  - Synthesis of 7 alpha-methoxy-7-[2-(substituted thio)acetamido]cephalosporin
      derivatives and their antibacterial activities.

PMID- 1017102
TI  - Determination of aldolase activity in serum.

PMID- 1017103
TI  - Studies on benzoheterocyclic derivatives. XVI. Synthesis and analgesic action of
      benzofuran derivatives.

PMID- 1017104
TI  - Effects of 1,2-benzisoxazole-3-acetamidoxime on central monoamine neurons in the
      rat.

PMID- 1017105
TI  - Phosphorus in organic synthesis. XII. Amino acids and peptides. XXII. Reaction of
      penicillin sulfoxides with diethyl phosphorocyanidate (DEPC).

PMID- 1017106
TI  - Physical properties of pyrimidine and purine antimetabolites. II. Permeation of 5
      fluorouracil and 1-(2-tetrahydrofuryl)-5-fluorouracil through cellophane,
      collagen, and silicone membranes.

PMID- 1017107
TI  - Analysis of the correlation between collagen and desoxyribonucleic acid syntheses
      under the influence of hydroxyurea in the inflammatory connective tissue.

PMID- 1017108
TI  - Studies on drug metabolism by use of isotopes. XVII. Mass spectrometric
      quantification of urinary metabolites of deuterated l-ephedrine in man.

PMID- 1017109
TI  - Molecular weight determination and the secondary structure of the hypocalcemic
      protein purified from bovine parotid gland.

PMID- 1017110
TI  - Molecular orbital index-activity relationship between atrial antiarrhythmic
      activity and disopyramide derivatives.

PMID- 1017111
TI  - Stimulation of serum protein synthesis in ginsenoside treated rat.

PMID- 1017112
TI  - Transmucosal fluid movement and intestinal drug absorption in alloxan diabetic
      rats.

PMID- 1017113
TI  - Metabolism of budralazine, a new antihypertensive agent. I. Identification of the
      metabolites of budralazine in rats.

PMID- 1017114
TI  - Anticoccidials. I. Syntheses and anticoccidial activity of 2-amino-5-aryl-1,3,4
      oxadiazoles, 5-alkoxy-3-aryl-1H-1,2,4-triazoles, and 3-aryl-delta2-1,2,4
      triazolin-5-ones.

PMID- 1017115
TI  - Multiple forms of rat kidney mutarotase.

PMID- 1017116
TI  - Vespakinin-M, a novel bradykinin analogue containing hydroxyproline, in the venom
      of Vespa mandarinia Smith.

PMID- 1017117
TI  - Fluorophotometric assay of proteins using hypochlorite-thiamine reagent.

PMID- 1017118
TI  - [Pseudocysts of the pancreas. (Personal cases)].
AB  - After reviewing all the various procedures for surgical treatment of pseudocysts
      of the pancreas, the Authors, analysing the advantages and disadvantages of each
      method, present a set of nineteen personal cases treated by simple
      cystogastrostomy, simple cystojejunostomy and cystojejunostomy combined with
      entero-entero-anastomosis according to Braun, or cystojejunostomy on
      defunctionalised loop according to Roux. After stading the overall criteria for
      selection of the technique to be applied individually, the Authors conclude by
      stressing the advantages that cystojejunostomy on defunctionalised loop according
      to Roux offers as compared with all the other procedures.

PMID- 1017119
TI  - [Gastroesophagitis caused by biliary reflux in gastrectomized patients].

PMID- 1017120
TI  - [Arteriovenous fistulas in hemodialytic treatment].
AB  - In view of the necessity for patients under periodical dialysis to preserve in
      operating condition the artero-venous fistulas performed on them, so that the
      application of the dialytic processes is extended as much as possible, particular
      technical suggestions are put forward, also taking into account the requirements
      of immediate dialysis for acute uremia and endeavouring to recover any artery and
      vein that may be used for external by-passes.

PMID- 1017121
TI  - [Use of the femoral artery for chronic hemodialytic treatment].
AB  - In 4 patients subjected to periodical haemodialytic treatment a new route of
      access to the vessels was used; the common femoral artery and the large saphena
      to the outlet into the femoral vein. All four patients presented serious problems
      with regard to application of a new shunt in view of the previous reiterated use
      of the vessels commonly utilized. At the maximum distance of 46 months from
      implantation, only one of the four by-passes is still in use; 2 were removed for
      obstruction and the fourth, still operating at the time, was removed for a renal
      transplant performed on the patient. In view of the frequency  of troubles and
      the use-months of the femoral by-pass compared with the traditional ones, the
      femoral route of access may be considered favourably when the traditional shunt
      implantation or fistula creation procedures are precluded.

PMID- 1017122
TI  - [Retroperitoneal liposarcoma].
AB  - The various aspects of this comparatively rare neoplasia are discussed on the
      basis of two cases of retroperitoneal liposarcoma and an analysis of the
      literature. Consideration are expressed on the clinical symptoms, the
      pathological anatomy, its marked tendency to evolve with repeated local relapses
      and the need to properly localise the mass and the feeding peduncles prior to the
      operation, so that radical exercise can be performed, since this leads to a more
      favourable long-term prognosis. The utility of radiotherapy, which leads to a
      lengthened period of freedom from the disease and to an increased  survival time,
      is also stressed.

PMID- 1017123
TI  - [Benign gastric tumors. A case of torsion of a gastric angiocavernoma].

PMID- 1017124
TI  - [Presentation of an orthopedic corset for low scoliosis].

PMID- 1017125
TI  - [Senile dysplasias of Vater's ampulla].
AB  - Adenomiosis of Vater's papilla is an organospecific dysplastic process, clearly
      linked to age and not dependent on other pathological processes of the biliary
      axis. The reasons for which it is diagnosed in preoperative biopsies with a
      frequency lower than should be expected on the basis of investigations performed
      on cadavers are stated. In particular, pathogenetic weight is stressed as a cause
      of Vaterian stenosis, especially in elderly subjects cholecystectomized many
      years earlier.

PMID- 1017126
TI  - [New method of solid phase radioimmunologic determination of total serum
      thyroxine compared with the competitive technic (T4-test)].

PMID- 1017127
TI  - [Role and aspects of cardiothyreosis in the Senegalese. Apropos of 35
      hospitalized cases].

PMID- 1017128
TI  - [Hyperthyroidism in children. Apropos of 6 cases observed inthe Pediatric
      Department of the University Teaching Hospital, Dakar].

PMID- 1017129
TI  - [Neuromuscular manifestations of thyroid diseases].

PMID- 1017130
TI  - [Panorama of thyroid diseases at the Hopital Principal from 1972 to 1975].

PMID- 1017131
TI  - [Cold thyroid nodules (apropos of 170 operated cases)].

PMID- 1017132
TI  - [A case of neonatal goiter observed at the University Hospital Center of Dakar].

PMID- 1017133
TI  - [Pulmonary miliaria revealing a thyroid cancer in a 7-year-old girl].

PMID- 1017134
TI  - [Endemic goiter in Kati (survey conducted in the Samakebougou quarter)].

PMID- 1017135
TI  - [Postpartum pan-hypopituitarism in a Senegalese (Sheehan's syndrome)].

PMID- 1017136
TI  - [A new hemoglobin C with sickling: hemoglobin C Ziguinchor. Its discovery and
      observation in an African Senegalese family].

PMID- 1017137
TI  - [Comatose forms of purulent meningitis].

PMID- 1017138
TI  - [Cerebral vascular malformations in Senegal. II. Development, treatment and
      prognosis].

PMID- 1017139
TI  - [Wallenberg's syndrome revealing Osler's endocarditis in an adult Senegalese with
      undiscovered mitral stenosis].

PMID- 1017140
TI  - [Multiple cancers in Senegal. Apropos of 10 cases observed in the Institut du
      Cancer de Dakar].

PMID- 1017141
TI  - [Treatment of poliomyelitic hips. 4 year's experience in Dakar].

PMID- 1017142
TI  - [A case of cervico-brachalgia caused by apophysomegaly, treated surgically].

PMID- 1017143
TI  - [Fracture-dislocations of the astragalus. Apropos of 5 cases].

PMID- 1017144
TI  - [Recent diaphyseal fractures of the femur. Therapeutic indications and results
      apropos of 157 cases].

PMID- 1017146
TI  - [Study of comparative sensitivity to tuberculin in lepromatous and tuberculoid
      lepers (preliminary data-February 1976)].

PMID- 1017145
TI  - [Pleuro-pulmonary aspergillosis in African blacks (apropos of 5 cases observed in
      Dakar)].

PMID- 1017147
TI  - [Basic principles in the use of ultrasound in cardiology].

PMID- 1017148
TI  - [Use of radiculosaccography in radiologic examination of sciatica].

PMID- 1017149
TI  - [Use of continuous monitoring of glycemia in the study of sugar diabetes. 2.
      Special significance early diagnosis of sugar diabetes].

PMID- 1017150
TI  - [What precedes hypoglycemia in the adult?].

PMID- 1017151
TI  - [Adverse effects of acetylsalicylic acid].

PMID- 1017152
TI  - [Problems in tympanoplasty. Personal methods].

PMID- 1017153
TI  - Clinical pharmacokinetics in infants and children.
AB  - Wide variations in drug dose recommendations for children of the same or
      different ages reflect the inadequacy of data on pharmacokinetics and
      pharmacodynamics in children. Selected aspects of available literature on
      pharmacokinetics of drugs used in older infants and children has been reviewed
      with special attention to calculation of an age-appropriate dose. During the
      neonatal period and early infancy the elimination of many drugs that are excreted
      in the urine in unchanged form is restricted by the immaturity of glomerular
      filtration and renal tubular secretion. On the other hand, in late infancy and/or
      in childhood, a similar or greater rate of elimination from plasma than in adults
      has been observed for many drugs, notably digoxin, phenobarbitone, phenytoin,
      carbamazepine, ethosuximide, diazoxide, clindamycin and propoxyphene. Consistent
      with this, it has been shown that some drugs exhibit a lower plasma level/dose
      ratio in infancy and early childhood as compared with the adult. This is true for
      phenobarbitone, phenytoin and ethosuximide. Some age groups of children remain
      uninvestigated with regard to pharmacokinetics, even for the drugs reviewed.
      Therefore, pediatric therapy remains empirically based for many drugs.

PMID- 1017154
TI  - Pharmacokinetics and effects of propranolol in terminal uraemic patients and in
      patients undergoing regular dialysis treatment.
AB  - Propranolol blood and plasma levels were measured after a single oral dose of 40
      mg in patients with chronic renal failure, in patients undergoing regular
      dialysis treatment, and in healthy volunteers. Peak levels were observed in all
      cases within 1.5 to 3 hours. However, peak blood and plasma concentrations of
      propranolol in the chronic renal failure group were 2- to 3-fold higher (161 +/-
      41 ng/ml) than those observed in the dialysis patients (47 +/- 9 ng/ml) and in
      the healthy volunteers (26 +/- 1 ng/ml). The apparent plasma clearance was also
      significantly reduced in the patients with chronic renal failure. The data
      suggest a reduced hepatic extraction in chronic renal failure patients. A
      significant increase in the fraction of the dose available to the systemic
      circulation was also found, together with a modification of apparent plasma half
      life and volume of distribution in regular dialysis patients during the dialysis
      day as compared with the after-dialysis day. No extraction of propranolol by the
      dialyzer was noticed. Marked fluctuations in propranolol blood concentrations
      were also observed in patients on regular dialysis following continuous
      propranolol treatment. The suppressive effect of propranolol on plasma renin
      activity did not fully correlate with the hypotensive effect of the drug. On the
      basis of the reported data, propranolol should be used with great caution and at
      low doses in chronic renal failure.

PMID- 1017155
TI  - [Coenzyme A in viral hepatitis].

PMID- 1017156
TI  - [Further studies of antidiuresis induced with carbamyldibenzoazapine and with
      ethyl parachlorophenoxyisobutyrate in diabetes insipidus].

PMID- 1017157
TI  - [Calculosis of the biliary tract: clinico-statistical considerations on 1,000
      cases].

PMID- 1017158
TI  - [Autoimmunity and autoimmune diseases. Meeting on the treatment of autoimmune
      diseases. Introduction].

PMID- 1017159
TI  - [Clinical use of a new hypoglycemic agent: buformin].

PMID- 1017160
TI  - [Current trends in chemoantibiotic therapy of tuberculosis].

PMID- 1017161
TI  - [Death of the heart: physiopathological, electrocardiographic and therapeutic
      aspects. Personal observations].

PMID- 1017162
TI  - [Treatment of gout].

PMID- 1017163
TI  - [Relationship between renin-aldosterone system and efficacy of a beta-blocking
      agent in hypertensive patients].

PMID- 1017164
TI  - [Electrophysiologic effects of verapamil in patients with conduction
      disturbances. Studies of 16 cases by recording  of the electrocardiogram of the
      bundle of His].

PMID- 1017165
TI  - [Case of nonsecretory multiple myeloma].

PMID- 1017166
TI  - [Treatment of obesity in infancy and adolescence. I. Findings on frequency and
      assessment of weight loss in relation to patient's age and sex, type of obesity
      and duration of the disorder].

PMID- 1017167
TI  - [Multicentric monohospital trial of a new antibiotic preparation].

PMID- 1017168
TI  - [Combination of amiloride chlorhydrate and hydrochlorothiazide in the ambulatory
      treatment of mild and moderate hypertension].

PMID- 1017169
TI  - [Side and toxic effects of salicylates].

PMID- 1017170
TI  - [Therapy of obesity in childhood and adolescence. II. Comparison of results
      obtained with dietary and drug treatment].

PMID- 1017171
TI  - [Use of rifampicin in venous perfusion in a group of patients with pulmonary
      tuberculosis].

PMID- 1017172
TI  - [Toxic coma due to drugs].

PMID- 1017173
TI  - [Current trends in the diagnosis and treatment of rheumatoid arthritis].

PMID- 1017174
TI  - [Preliminary study on hemodynamics in heart patients treated with a single dose
      of indoprofen].

PMID- 1017175
TI  - [Uric acid calculi: therapeutic trends].

PMID- 1017176
TI  - [Paraneoplastic syndrome treated with indomethacin].

PMID- 1017177
TI  - Photoepicutaneous testing with the chamber method.
AB  - The chamber test, so far successfully applied to epicutaneous testing, proved to
      be suitable for photoepicutaneous testing as well. A simple and reliable method
      was developed by dividing the test areas (after removing the tests from the skin)
      into two equal parts, one for ultraviolet irradiation and the other for dark
      control. Variations in the amounts of the test substances had a slight influence
      on the size but not on the strength of the reactions.

PMID- 1017178
TI  - Allergic contact dermatitis from propellants in deodorant sprays in combination
      with allergy to ethyl chloride.
AB  - Allergic contact eczema from the use of deodorant sprays is sometimes caused by
      sensitization to the propellants. Positive reactions were seen in three patients
      when patch testing to Freon 11 (trichloromonofluoromethane). One patient also
      reacted to Freon 12 (dichlorofluoromethane). Another patient had an eczematous
      eruption after ethyl chloride was sprayed on the skin prior to taking biopsy. The
      two other patients showed strongly positive patch tests with this compound.
      Further investigations of the sensitizing capacity propellants with chemical
      resemblance have to be carried out to solve the problem of cross-sensitization.

PMID- 1017179
TI  - Scindapsus dermatitis.

PMID- 1017180
TI  - Rejection of metal to metal prosthesis and skin sensitivity to cobalt.
AB  - Metal to metal prostheses give satisfactory results in 90% of patients. About
      half of the failure rate may be due to allergic reaction to the metals involved,
      particularly cobalt. A total of 35 patients in this unsatisfactory group have
      been patch-tested; 16 were positive to metals, 13 to cobalt, 4 to nickel, and 2
      to chromate. Only two patients showed any skin lesions - one a localized
      dermatitis round the knee joint from nickel sensitivity, and one to cobalt who
      had a widespread scattered circular erythematous lesion suggestive of a
      generalized allergic vasculitis. Patients requiring a metal/metal prosthesis
      should have a careful history taken for metal sensitivity and be patch-tested
      with the metals. All the patients in this investigation had metal/metal
      prostheses and no reaction was seen after metal/high density polyethylene
      implants. Titanium 318 may be a satisfactory substitute for cobalt chrome alloy
      if reactions are encountered.

PMID- 1017181
TI  - Phytophotodermatitis from Heracleum mantegazzianum.
AB  - Five individuals developed striate bullous dermatitis two days after exposure on
      a clear day to Heracleum mantegazzianum, Umbelliferae (Parsnip) family.
      Photopatch testing confirmed phototoxicity from the plant. This and 28 other
      Heracleum species yield linear furanocoumarins.

PMID- 1017182
TI  - Cement burns.
AB  - Four cases are presented of men who sustained burns after contact with premixed
      concrete. The pathogenesis of the condition is discussed.

PMID- 1017183
TI  - Sensitization to propantheline bromide, trichlorocarbanilide and propylene glycol
      in an antiperspirant.
AB  - Out of 14 patients with axillary dermatitis due to an antiperspirant, and with
      positive patch test reactions to the product, the sensitizer could be
      demonstrated in 12. Of these, 11 were positive to propantheline bromide, 3 to
      trichlorocarbanilide and one to propylene glycol. The antiperspirant contains 90%
      propylene glycol, which is an irritant under occlusion. When applied in the
      axillae, where occlusive conditions usually prevail, an irritant effect of
      propylene glycol may have promoted sensitization to the ingredients of the
      antiperspirant.

PMID- 1017184
TI  - Contact hypersensitivity to sesquiterpene lactones in Chyrsanthemum dermatitis.
AB  - In six persons with contact allergy to chrysanthemum of florists, patch tests
      were performed with 25 sequiterpene lactones. Positive responses were observed to
      15 lactones. The most frequently encountered positive responses were to
      alantolactone (positive in all cases) and to arbusculin A, 8-deoxycumambrin,
      ambrosin, damsin and psilostachynin. The findings corroborate the assumption that
      an alpha-methylene group attached to the gamma-lactone ring is an essential
      prerequisite for allergenic activity of sesquiterpene lactones. Pyrethrum
      produced a positive reaction in one of the patients, pyrethrins gave negative
      reactions in all. Some of the chrysanthemum patients were also hypersensitive to
      turpentine and colophony and to garlic, primin and tars.

PMID- 1017185
TI  - Results of routine office patch testing.
AB  - The results of patch testing over the past 18 months in a general dermatology
      clinic are presented and compared with the data recently reported by the North
      American Contact Dermatitis Group. Good correlation exists between the results of
      the two studies for all the reported allergens except nickel sulfate and
      potassium dichromate. The increased incidence of sensitivity to these allergens
      reported in our series probably reflects the tendency for all metal related
      contact dermatitis to be referred to our clinic, even though recognized as such
      by the referring physician. The 16.8% reactivity to a dye mix used in our
      screening kit, and not reported by others, proved most interesting. In the light
      of continuing reports of dye related allergic contact dermatitis, our experience
      prompts us to suggest that a dye mix of some sort should be evaluated in future
      large-scale studies of patch test screening kits.

PMID- 1017186
TI  - Squaric-acid-diethylester - a strong sensitizer.
AB  - A patient developed a circumscribed contact dermatitis after a single contact
      with squaric-acid-diethylester (SADE). Patch tests with low concentrations of
      SADE were positive. Based on these observations, experimental studies on the
      sensitizing capacity of SADE were performed on guinea-pigs. The results disclosed
      that this compound is a strong sensitizer. Derivatives of SADE, such as the
      nearly insoluble squaric acid, squaric acid-1,2-diamide and dithio-N,N'
      dicyclohexyle-1,2-diamide were not able to produce allergic skin reactions in the
      sensitized patient nor in guinea pigs. The chemistry and the range of uses of
      squaric acid and its derivatives are briefly mentioned. A hypothesis on the
      molecular mechanism of conjugation of SADE to human proteins and thereby on
      sensitization is discussed. A warning is given for taking precautionary measures
      before handling this substance.

PMID- 1017187
TI  - Allergic contact dermatitis to a salicyclic acid plaster.
AB  - We report two patients who developed allergic eczematous contact dermatitis to a
      salacid plaster used to treat plantar warts. Both patients were subsequently
      shown to be allergic to dehydroabietic acid, a resin contained in the plaster.

PMID- 1017188
TI  - Computer-derived exposure lights for common contact dermatitis antigens.
AB  - An established computer file was searched for lists of products containing 45
      antigens recognized as causes of allergic contact dermatitis. The final lists
      included over 8000 products. The problem, ptoential and limitations of such lists
      are discussed.

PMID- 1017189
TI  - Histological differences between irritant and allergic patch test reactions in
      man.
AB  - The results of a study of the histological aspects of the application of DNCB on
      the skin of unsensitized and sensitized persons are discussed. The nature of the
      histological changes in primary irritant and allergic reactions to DNCB in human
      skin appeared to be identical. The differences appeared to be primarily of a
      quantitative character. It is furthermore concluded from data in the literature
      that the skin of some persons may react with a primary irritant reaction to
      concentrations of a compound thought to cause only allergic reactions. In these
      persons histological examination of the patch test result may give insufficient
      clues as to the nature of the reaction. The practical consequences of the data
      presented are discussed.

PMID- 1017190
TI  - The development of metal hypersensitivity in patients with metal-to-plastic hip
      arthroplasties.
AB  - Sixty-six patients who had to undergo total hip replacement by means of a metal
      to-plastic Stanmore prosthesis, were patch-tested prior to and 6 to 12 months
      after surgery with the standard ICDRG all allergens series and with acrylic
      monomer 5% in acetone. In 62 patients the history of metal allergy as well as the
      patch tests to all tested allergens were negative. One patient with a history of
      metal allergy reacted negatively before surgery; about 6 months after surgery the
      patch test to nickel sulphate was positive (2 plus). Three other patients
      developed positive patch test reaction after surgery: two reacted positively to
      nickel sulphate (2 plus) and one to cobalt chloride (2 plus). In none of the 66
      patients have local side effects of the prostheses been found to date.

PMID- 1017191
TI  - Phototoxicity of methoxsalen in various vehicles.
AB  - Methoxsalen (8-methoxypsoralen) was used as the photoxic substance in the study
      of the properties of various vehicles in photoepicutaneous testing. Macrogols as
      such were relatively poor bases, and positive reactions were seen only
      occasionally at a concentration of 0.05% methoxsalen. Increasing amounts of water
      in macrogols brought forth more numerous and stronger reactions. The photoxicity
      also increased when ethanol was added. The reactions were, however, weaker than
      to those with aqueous bases. Wool fat and glycerol as vehicles usually reacted in
      the same way as polyethylene glycols when water was added. An explanation of the
      mechanism of the changes in the properties of vehicles due to the addition of
      water/ethanol requires further investigation.

PMID- 1017192
TI  - Incidence of neomycin and framycetin sensitivity.
AB  - A total of 450 consecutive patients were patch-tested to both neomycin and
      framycetin (20% in petrolatum). Thirteen patients were sensitive to both
      preparations, 10 to neomycin alone and four to framycetin alone. The significance
      of these results is discussed, with particular reference to the constituents of
      the preparations and the allergenic groups involved.

PMID- 1017193
TI  - Validity of patch test results.

PMID- 1017194
TI  - Contact hypersensitivity to glycerol.

PMID- 1017195
TI  - Routine patch testing with Irgasan DP 300.

PMID- 1017196
TI  - Allergy to balsam of Peru and wood tars: an increasing problem?

PMID- 1017197
TI  - Colophony collar dermatitis.

PMID- 1017198
TI  - Preoperative cervical dilatation by oral PGE2.

PMID- 1017199
TI  - A statistical study of the copper T and copper 7 intrauterine devices.

PMID- 1017200
TI  - Evaluation of 15(S) 15-methyl-PGF 2 alpha-methyl ester vaginal suppositories for
      cervical dilatation and second trimester pregnancy termination.

PMID- 1017201
TI  - Intravaginal contraception with the synthetic progestin, R2323.

PMID- 1017202
TI  - Comparative study of the estrogenic effect of ethinylestradiol and mestranol on
      the endometrium.

PMID- 1017203
TI  - A study of four antigon models and factors in the use-effectiveness of the IUD.

PMID- 1017204
TI  - The place of irradiation in the treatment of malignant tumors of the salivary
      glands.
AB  - 1. Radiation therapy is not indicated after surgical removal with adequate
      margins of low-grade tumor. 2. Radiation therapy is indicated with a) Inadequate
      surgical margins in low-grade tumors b) All high-grade tumors c) All recurrent
      malignant tumors 3. Irradiation of nerve pathways is indicated with demonstrated
      nerve and perineural invasion and/or with adenoicystic carcinoma. 4. Irradiation
      of the entire ipsilateral neck is indicated a) Wtih high-grade tumors unless
      radical neck dissection shows negative nodes b) In the place of radical neck
      dissection.

PMID- 1017205
TI  - Radiation therapy in the management of carcinoma of the prostate.

PMID- 1017206
TI  - Soft tissue sarcomas.

PMID- 1017207
TI  - Combined irradiation and surgery for rectal and sigmoid carcinoma.

PMID- 1017208
TI  - The systolic click-murmur syndrome: clinical recognition and management.
AB  - The midsystolic click-late systolic murmur syndrome is a complex entity with
      variable manifestations that involves a primary process causing myxomatous
      degeneration of the mitral valve leaflet(s) and subsequent systolic mitral valve
      leaflet prolapse. Other cardiac diseases may cause mitral valve prolapse and
      regurgitation associated with a midsystolic click that mimics this primary
      syndrome. The prolapsing mitral valve leaflet(s) syndrome occasionally may be
      familial. Most patients are asymptomatic but some complain of chest pain,
      palpitation, dyspnea or fatigue. Prolapsing mitral valve leaflet(s) can be
      distinguished from other causes of systolic clicks and mitral regurgitation
      murmurs by the characteristic movement of the clikmurmur complex in systole with
      various hemodynamic interventions. The clinical diagnosis usually can be
      confirmed by echocardiography, which demonstrates the abnormally prolapsdrome
      usually is minimal but can be progressive and lead to the need for prosthetic
      valve replacement. Most symptomatic patients can be managed medically but some
      require cardiac catheterization to evaluate the possibility of coexistent
      coronary artery disease, to assess the degree of mitral regurgitation and to
      evaluate other associated cardiac lesions. All patients with this syndrome should
      receive antibiotic prophylaxis prior to any surgical or dental procedures. Those
      patients suspected of having arrhythmias should be evaluated by continuous
      ambulatory ECG monitoring and dangerous arrhythmias probably should be treated.
      The prognosis usually is excellent, but sudden death and rapidly progressive
      mitral regurgitation due to ruptured chordae tendineae have been reported.
      Although more than a decade has elapsed since the midsystolic click-late systolic
      murmur syndrome was first recognized, much remains to be learned about this
      common but complex clinical entity.

PMID- 1017209
TI  - Innocent vs significant murmurs.

PMID- 1017210
TI  - Choices for intravascular contrast agents.

PMID- 1017211
TI  - Therapeutic instruction.

PMID- 1017212
TI  - When can a baby make antibody?

PMID- 1017213
TI  - Semi-permanent hair color.

PMID- 1017214
TI  - The "vanilla fudge" cyst.
AB  - A white cyst, partially covered by jet black splotches and streaks, had a surface
      appearance of vanilla fudge ice cream. Histologically, the cyst was lined with
      two distinctly different types of follicular epithelium--one identical to that of
      the infundibulum and the other to that of the matrix. The black pigment was
      melanin, produced by numerous dendritic melanocytes that were situated only in
      the region of the epithelium-resembling matrix.

PMID- 1017215
TI  - Cutaneous bilharzial granulomas: a histopathologic study.
AB  - Histopathological studies were done on seven cutaneous lesions; all but two were
      clinically diagnosed as cutaneous bilharzial granulomas. Epidermal, dermal,
      vascular, sweat and sebaceous gland changes were demonstrated. The purpose of
      this paper is to present the pathogenesis of these granulomas.

PMID- 1017216
TI  - Update: seabather's eruption and swimmer's itch.
AB  - Swimmer's itch and seabather's eruption, while similar in morphology, differ in
      important aspects. Seabather's eruption occurs chiefly in salt water and involves
      covered parts of the body. Swimmer's itch occurs chiefly in fresh water and
      involves uncovered parts. The cause of swimmer's itch is definitely known to be
      schistosome cercariae, while the cause of seabather's eruption is for the most
      part unknown. Algae, coelenterates and schistosomes as well as other organisms
      found in seawater have been suggested. Control of swimmer's itch is best
      accomplished by decreasing the snail population.

PMID- 1017217
TI  - Observations on a lactate-containing emollient cream.

PMID- 1017218
TI  - Cutaneous Hodgkin's disease.
AB  - A case of specific cutaneous Hodgkin's disease, which is sparsely mentioned in
      the literature, is reported. The lesion was nodulo-ulcerative and corresponded to
      the Grosz-Hirschfield type. It was confirmed by biopsy and the pattern was
      similar to that of an excised supraclavicular node examined two years previously.
      The lesion responded to treatment with gentamicin topically, clindamycin orally
      and 500 r of cauterizing X-ray. There has been no recurrence to date and no other
      new cutaneous lesions. This report further confirms what Ferdinand von Hebra
      implied one hundred years ago--that a dermatologist should not only know skin
      diseases but also the cutaneous manifestations of visceral diseases.

PMID- 1017219
TI  - Scalp psoriasis: improved treatment with a shampoo machine.

PMID- 1017220
TI  - Trichloroacetic acid peeling.
AB  - Trichloroacetic acid peeling refers to a system whereby a corrosive chemical is
      applied to the skin. The resultant good effect is due to epidermal regeneration,
      as well as the regenerating of new collagen in the dermis. The technique of deep
      chemical peeling in treatment of actinic degeneration and acne scarring is
      presented.

PMID- 1017222
TI  - Infantile asthma.

PMID- 1017221
TI  - Reactions to antioxidants in cosmetics and foods.

PMID- 1017223
TI  - Laser surgery in cosmetic dermatology.

PMID- 1017224
TI  - Cutaneous manifestations of hypothyroidism including purpura and ecchymoses.
AB  - Hypothyroidism has distinctive cutaneous manifestations which may be diagnostic.
      Biopsy and histologic study of the skin may provide a simple and useful tool for
      diagnosing hypothyroidism. Purpura and ecchymoses, although not often mentioned
      among cutaneous manifestations of hypothyroidism, occurred in nine of 222
      hypothyroid patients at Ochsner Clinic between 1958 and 1972.

PMID- 1017225
TI  - Herpes zoster: a cause of acute detrusor muscle paralysis.
AB  - The essence of this report is to apprise the dermatologist of this fascinating
      but unusual complication of herpes zoster and to underscore the help he may give
      in establishing the diagnosis along with assisting in the management of this
      disorder.

PMID- 1017226
TI  - Photoallergy induced by quinidine.
AB  - An 82-year-old woman presented with a lichenified dermatitis over light-exposed
      areas. The eruption cleared upon withdrawal of quinidine and recurred on re
      administration of the drug. Though quinidine has not been recognized as a photo
      sensitizing agent, upon review of the literature we have uncovered other cases
      which meet the criteria and justify including this drug among those capable of
      causing such reactions.

PMID- 1017227
TI  - Coexistence of discoid lupus erythematosus and porphyria cutanea tarda.
AB  - A case of coexistent porphyria cutanea tarda and discoid lupus erythematosus is
      presented. Abnormal urinary porphyrins, the presence of liver fluorescence,
      chronic alcoholism, fatty metamorphosis of the liver and histologically typical
      LE with the demonstration of basement membrane fluorescence were present in the
      patient. Awareness of the possible coexistence of these two conditions is of
      practical significance for the practicing dermatologist. The nature of the
      relationship between these conditions remains obscure. Is it coincidental or does
      it represent a common pathophysiological mechanism? Further work on this unique
      pair of diseases seems indicated.

PMID- 1017228
TI  - Acute neutrophilic dermatosis.

PMID- 1017230
TI  - Wrinkles.

PMID- 1017229
TI  - Porphyria precipitated by hydroxychloroquine treatment of systemic lupus
      erythematosus.
AB  - This case report emphasizes the fact that patients presenting with
      photosensitivity could have lupus erythematosus or porphyria or both; and since
      the therapy for one may aggravate the other, extreme caution is indicated.

PMID- 1017231
TI  - Allergic conjunctivitis.

PMID- 1017232
TI  - Radiotherapy of skin cancer: modern indications and techniques.
AB  - Skin cancer is the most frequent indication for radiation therapy in dermatology.
      X-ray treatments are particularly valuable in cutaneous neoplasms in special
      anatomical locations. Advantages and disadvantages of dermatologic radiation
      therapy are outlined, and modern indications, radiation methods and the selection
      of physical radiation factors are discussed.

PMID- 1017233
TI  - Geographic lip: a variant of geopgraphic tongue.
AB  - The following aspects of the classic geographic tongue are discussed: clinical
      polymorphism with the appearance of annulus migrans, histological appearacne of
      the spongiform pustule, frequent association with pustular psoriasis and related
      diseases, and its relationship to psoriasis buccalis. Two cases of geographic lip
      are described in which annulus migrans was present. In one case, the geographic
      lip was associated with a plicated lip, a labial form of plicated tongue.

PMID- 1017234
TI  - Lichen spinulosus: response to therapy.
AB  - Two cases of lichen spinulosus and the response to therapy with Keralyt under
      occlusion are presented. It is evident that Keralyt under occlusion for two
      consecutive weeks will clear these lesions. However, twice weekly application of
      Keralyt must be used in order to keep these areas free of lesions. An undesirable
      side effect in the two patients presented was a burning, stinging sensation
      immediately following application of Keralyt.

PMID- 1017235
TI  - Common warts: immunity as a result of therapy.
AB  - Warts that don't regress frequently have wart cell specific immune globulin
      M(IgM), but no wart virus specific Immune Globulin M (IgM) in the circulatory
      system. Warts that regress spontaneously have multiple circulating antibodies
      wart cell specific IgM, IgG, and IgA. When the antibodies of IgG class appear in
      the circulation, the warts will commonly disappear. Topical application of cell
      toxic, irritant materials will elicit discernible amounts of virus specific IgM
      and IgG. Those B Cells which produce IgG have a "computer bank memory" and IgG
      should be recalled if wart virus antigen reappears as a result of reinfection.
      Therefore, persistent, consistent, topical application of irritant modalities to
      warts that will cause them to regress and disappear, should confer immunity on
      the individual through the production of wart virus specific IgG. Over a seven
      year span 150 cases of wart were cleared in our office by an irritant method. In
      that group of cases there were eight recurrences. Two cases cleared spontaneously
      within two weeks, and four cleared with an acute inflammatory response within a
      few days of reirritation.

PMID- 1017236
TI  - Accidental vaccinia of the vulva.
AB  - Vaccinia of the vulva in a 32-year-old married woman is described. The
      vaccination was apparently due to a heteroinoculation from her husband during
      sexual contact. Clinically it presented as an indurated ulcer with a few isolated
      umbilicated vesicles and was associated with an acute biological false-positive
      serological reactions.

PMID- 1017237
TI  - Tinea pedis in children.
AB  - Many children have dermatoses involving the feet. Such problems are often
      misdiagnosed as tinea pedis, which is relatively uncommon in this age group. On
      the other hand, tinea pedis should not be ignored as a diagnostic possibility
      just because of its infrequent occurrence. Six cases are reported to demonstrate
      that this diagnosis will be missed if appropriate laboratory studies are not done
      as a part of the evaluation of these dermatoses.

PMID- 1017238
TI  - Hormonal dependency in Darier disease.
AB  - Variation in the severity of keratosis follicularis relative to states of homonal
      change was noted in eight women with the disease. Observations included frequent
      onset near puberty, puberty, exacerbation during menses, and improvement while
      patients are pregnant or on oral contraceptive agents. It is proposed that states
      of relative estrogen excess are associated with quiescence of this skin disorder.
      In support of this hypothesis, three postpubertal women with Darier desease were
      observed to undergo significant improvement with the use of estrogen-dominant
      birth control pills.

PMID- 1017239
TI  - An introduction to dynamic dermatology for residents and fellows starting
      dermatology training.

PMID- 1017240
TI  - Axillary and inguinal striae induced by systemic absorption of a topical
      corticosteroid.
AB  - A 21-year-old woman developed huge atrophic striae in the axillary and inguinal
      areas from the topical application, with occlusion, of potent corticosteroid
      preparation applied to the axillary or inguinal areas. It is postulated that the
      mechanism is systemic absorption of enough medication to produce a state of
      hyperadrenalism with subsequent striae formation as a sequela.

PMID- 1017241
TI  - Lupus erythematosus exacerbated by griseofulvin.
AB  - Because griseofulvin is one of the safest systemic medications, its side effects
      are often forgotten. This paper serves as a reminder that griseofulvin can
      precipitate or exacerbate lupus erythematosus. Two patients are described: one
      had a photosensitivity reaction to griseofulvin which precipitated discoid LE
      skin lesions, without any previous evidence of LE. The other, who had known
      systemic LE, developed a systemic reaction, consisting of fever and malasise.

PMID- 1017242
TI  - Fibrodysplasia ossificans progressiva.

PMID- 1017244
TI  - Cryosurgery of skin cancer.

PMID- 1017243
TI  - Supernumerary nipple on the shoulder.

PMID- 1017245
TI  - The razor blade as a biopsy tool.

PMID- 1017246
TI  - Topical treatment for perioral dermatitis.

PMID- 1017247
TI  - Cosmetic aspects of cryosurgery.

PMID- 1017248
TI  - Making skin medicines attractive as well as effective.

PMID- 1017249
TI  - Flaunting the FDA--a hazard.

PMID- 1017250
TI  - Oral lesions of gonorrhea and syphilis.

PMID- 1017251
TI  - Molluscum contagiosum.

PMID- 1017252
TI  - Immunologic mechanisms of infectious syphilis.
AB  - We believe that humoral and cellular immunity both are involved in the response
      of the host to infection with T. pallidum. A complex interaction between
      stimulation and suppression of cell-mediated immunity may be involved. This
      interaction may explain the unusual clinical course in which secondary syphilis
      waxes and wanes before culminating in immunity.

PMID- 1017253
TI  - Lupus erythematosus and reactive tests for syphilis: update.
AB  - Sera of patients with lupus erythematosus can produce false-positive reactions in
      most serologic tests for syphilis, including the FTA-ABS test. False-positive
      reactions in the FTA-ABS test can exhibit beaded, borderline or reactive patterns
      of fluorescence. Beaded fluorescence is commonly associated with anti-DNA
      antibody and other correlates of lupus activity. Borderline and reactive results
      are common in both systemic and discoid lupus erythematosus, and are usually not
      associated with increased clinical activity. TPI and MHA-TP tests appear helpful
      in detecting false-positive FTA-ABS results.

PMID- 1017254
TI  - Examination of the cerebrospinal fluid in syphilis.
AB  - In the diagnosis of neurosyphilis, a cerebrospinal fluid cell count or
      cerebrospinal fluid total protein are inconclusive by themselves, but together
      with a cerebrospinal fluid VDRL are of great diagnostic value. At present, the
      VDRL Slide Test on Spinal Fluid remains the serologic test of choice for the
      diagnosis of neurosyphilis. The significance and specificity of treponemal tests
      on spinal fluid remain to be established. Like all other laboratory tests,
      cerebrospinal fluid findings may be variable and an absolute diagnosis of
      neurosyphilis should not be made on the result of any one laboratory test alone,
      but should be viewed in light of all laboratory evidence, including serum
      serologic tests, and clinical findings.

PMID- 1017255
TI  - The current status of gonococcal serology.

PMID- 1017256
TI  - Genital candidiasis: topical management with clotrimazole.
AB  - Clotrimazole was administered in the form of 100 mg tablets to patients with
      vaginal candidiasis, and in the form of a 1% solution to patients with cutaneous
      candidiasis of the genital and perigenital areas. The clinical and mycological
      response observed and the excellent tolerance and lack of side effects indicate
      that clotrimazole may be proposed as a treatment for candidiasis.

PMID- 1017257
TI  - Pseudoanaphylactic reactions with procaine penicillin.

PMID- 1017258
TI  - Syphilis in modern art.

PMID- 1017259
TI  - Cross-reactions between epoxy resin "amine" hardeners and ethylenediamine.

PMID- 1017260
TI  - Anesthesia and allergy.

PMID- 1017261
TI  - Home hair care.

PMID- 1017262
TI  - Allergic contact sensitivity. Personal experiences and observations.

PMID- 1017263
TI  - Ethnic pigmentation: 1975.

PMID- 1017264
TI  - Familial malignant melanoma.
AB  - Two sisters simultaneously developed a superficial spreading malignant melanoma
      on their legs. Concurrently, a brother was affected with fatal metastatic
      melanoma. Several explanations for familial malignant melanoma are reviewed,
      including: 1. Genetically determined predisposition; ,2 Phenotypic and
      environmental factors; and 3. Infectious etiology (virus?). Relatives of patients
      who develop malignant melanoma spould be aware that they have a higher risk than
      the general population of developing this serious type of cancer.

PMID- 1017265
TI  - Hidradenitis suppurativa occurring on the leg.
AB  - The case of a patient with a recurrent, painful ulceration on the lower leg,
      clinically and histologically resembling hidradenitis suppurativa, is presented.
      The fact that this site is devoid of apocrine glands supports the concept that
      apocrine involvement in hidradenitis suppurativa is coincidental and that these
      glands are involved secondarily. It is suggested that in this patient the
      pathogenesis of the disease is follicular occlusion rather than selective
      apocrine poral closure.

PMID- 1017266
TI  - Photolocalized tinea facialis.
AB  - The case of a 34-year-old white woman with tinea facialis that persisted for nine
      months prior to diagnosis is presented. The confluent plaquelike erythematous
      eruption of the face with eyelid lichenification that flared outdoors was thought
      to represent polymorphic light eruption and was refractory to antibiotics,
      corticosteroids (topical and systemic), and antimalarials. A KOH preparation was
      positive when the dermatosis spilled onto the mandibular region, and restaining
      of the initial skin biopsy revealed fungal hyphae. Complete resolution was
      accomplished with griseofulvin and MicTin. Tinea cab be added to the list of
      infectious agents that have a photosensitivity component. The fungus possibly
      "photolocalizes" to sun-damaged areas, ie, areas of increased capillary
      permeability. This case illustrates the importance of including tinea in
      considering diagnoses of sun-exposed lesions of the face.

PMID- 1017267
TI  - Acanthosis nigricans and wart-like lesions associated with metastatic carcinoma
      of the stomach.
AB  - A 63-year-old white man developed malignant acanthosis nigricans one year after a
      hemigastrectomy for adenocarcinoma of the stomach. Multiple "wart-like" lesions
      involving the dorsa of the hands, arms and trunk were also present. The malignant
      acanthosis nigricans in the patient appears to have paralledled the course of the
      metastatic gastric adenocarcinoma. Discrete verrucous lesions can occur in
      malignant acanthosis nigricans which histopathologically may show either squamous
      or basal cell hyperplasia.

PMID- 1017268
TI  - Poikiloderma vasculare atrophicans.
AB  - A 46-year-old Negro man with poikiloderma vasculare atrophicans is described. The
      disease progressed graduall.y for 22 years, with lesions appearing over the neck,
      trunk and extremities in an asymmetrical distribution, but it did not become
      lymphoma or collagen disease. Treatment did not appear to influence the course of
      the disease.

PMID- 1017269
TI  - Painful pigmented prosthesis pressure papules.
AB  - Two patients who presented with tender hyperkeratotic papules involving their
      weight-bear.ing amputation stumps were studied. Although these clinical findings
      are common in the experience of prosthetists, the author has been unable to find
      any documentation of these findings in the literature. All attempts at relining
      and reshaping the cups of the original offending prostheses by experienced
      prosthetists were unsuccessful. The eruption cleared only after entirely new
      prostheses were designed. It would appear that this condition is due to a poorly
      fitting prosthesis.

PMID- 1017270
TI  - Erythema chronicum migrans.
AB  - Erythema chronicum migrans is characterized by an expanding erythematous band
      about an arthropod bite. While rare, it is an important disease to recognize
      because of its rapid response to even modest doses of antibiotics. This response
      and the association with arthropod bites suggest a microbial vector. Richettsial
      titers have been demonstrated in several cases but we were unable to show them in
      our patient, who we believe is the second reported case of erythema chronicum
      migrans incurred by an American without traveling abroad.

PMID- 1017272
TI  - Allergy: 1976.

PMID- 1017271
TI  - Superficial and deep granulomatous lesions caused by Trichophyton violaceum.
AB  - A patient with cutaneous and reticulo-endothelial lesions, lymphadenopathy and
      osteitis caused by Trichophyton violaceum is presented. Two types of skin lesions
      were found: 1. Erythematous, scaly plaques on the arms, chest and abdomen; 2.
      areas of diffuse infiltration, granulomatous ulceration, fistulation and
      destruction of the sternal bone. Long-term treatment with penicillin,
      streptomycin, sulfonamides, and griseofulvin, gave temporary improvement.

PMID- 1017273
TI  - Epoxy resin dermatitis.

PMID- 1017274
TI  - Cosmetic dermatology: toward a common language.

PMID- 1017275
TI  - Insect sting allergy.
AB  - Allergy to insect stings may be quite serious, and occasionally lethal.
      Evaluation of these patients involves careful history taking. Skin testing for
      the stinging insects is helpful both for diagnosis and finding a beginning dose
      for hyposensitizing injections. According to many reports, these injections have
      been very effective in preventing subsequent severe reactions to insect stings.
      Prompt emergency treatment usually involves adrenalin injections. Insect
      avoidance procedures are effective.

PMID- 1017276
TI  - Allergic reactions to molds.
AB  - Allergy to mold is common, and results from inhalation of mold spores or
      ingestion of mold related foods. Mold spores are complex, hardy organisms capable
      of eliciting diverse immune responses and illnesses which may be mild or severe.
      Diagnosis and treatment with mold antigens are outlined and environmental
      recommendations made. Mechanisms of reactions to treatment of mold allergy are
      postulated.

PMID- 1017277
TI  - Treatment of asthma in adults.

PMID- 1017278
TI  - Hypersensitivity pneumonitis.

PMID- 1017279
TI  - Ocular allergy.

PMID- 1017280
TI  - Urticaria and angioedema.

PMID- 1017282
TI  - Cosmetic review.

PMID- 1017281
TI  - Psoriasis: treatment with a tar gel.
AB  - Crude coal tar has long been an effective and safe form of therapy for psoriasis.
      However, as compounded in an ointment base it has many objectional features and
      usually is limited to hospital use. A new tar gel has been studied which appears
      to equal the effectiveness of crude coal tar, is convenient to apply, and is
      cosmetically acceptable. This new tar preparation is a valuable addition to the
      therapy of psoriasis.

PMID- 1017283
TI  - The worldwide distribution leprosy: its impact on world health.

PMID- 1017284
TI  - Leprosy: differential diagnosis.

PMID- 1017285
TI  - Treatment of Hansen's disease.

PMID- 1017286
TI  - The so-called "salicylate-free diet.".

PMID- 1017287
TI  - Coloring the hair.

PMID- 1017288
TI  - Plantar squamous cell carcinoma.

PMID- 1017289
TI  - Dermatitis artefacta of the genitals.

PMID- 1017290
TI  - Nevoid basal cell carcinoma syndrome.
AB  - A case report of a young girl with nevoid basal cell carcinoma syndrome is
      presented. The patient showed cutaneous and skeletal findings characteristic of
      the syndrome. Multiple basal cell carcinomas, rib abnormalities, along with
      clinical evidence of frontal bossing and ocular hypertelorism were the primary
      features of the syndrome in this patient. It is suggested that other
      characteristics of the syndrome, such as jaw cysts, palmar and plantar pitting
      and calcification of the falx cerebri will develop as the patient grows older.
      Careful observation, particularly for medulloblastoma and malignant degeneration
      and invasiveness of basal cell carcinomas, will be an integral part of this young
      patient's care.

PMID- 1017291
TI  - Electrolysis---the dark horse referral.

PMID- 1017292
TI  - Suction cup ecchymosis of the forehead.

PMID- 1017293
TI  - Basal cell carcinoma of the scortum.

PMID- 1017294
TI  - Candidiasis of the lips.

PMID- 1017295
TI  - The chemical face peel.

PMID- 1017296
TI  - Malignancy treated with liquid nitrogen.

PMID- 1017297
TI  - Contact dermatitis with underlying malignancy.

PMID- 1017298
TI  - Erthropoietic protoporphyria: first report of cases in the American Nergo.
AB  - The first two cases of erthropoietic protoporphyria in the American Nergo are
      reported. The eruption was limited to the lips, subungual and periungual areas,
      which are relatively nonpigmented. Onset was at a later age and length of sun
      exposure required to produce symptoms was longer than that in most whites with
      the disease. The different presentation in Negroes is believed to be related to
      their increased pigmentation. Melanin appears to provide protection because of
      its free radical formation and absorption of 400 nm electromagnetic radiation.

PMID- 1017299
TI  - The esthetics of hair transplantation.
AB  - There are many potential candidates, and greater attention to esthetic
      considerations has accelerated the interest in the hair transplantation field.
      Although discriminatory selection is essential, there are few interested patients
      who could not benefit from this procedure. Successful hair transplantation and
      patient satisfaction depend on the physician's skillful sustained concentration
      on the frontal hairline, tenacious motivation of the patient to seek a sufficient
      number of transplants, and the choice of a pleasing hair style with utilization
      of recommended grooming aids.

PMID- 1017300
TI  - Painful bruise syndrome.

PMID- 1017301
TI  - The so-called salicylate-free diet. Part II.

PMID- 1017302
TI  - Hair dyes: temporary colorings.

PMID- 1017303
TI  - Skin changes and lesions in our senior citizens: incidences.
AB  - One hundred and sixty-three community volunteers were interviewed and examined.
      After a decade, the 69 survivors were again interviewed and examined. The
      incidences of their skin changes and lesions were recorded and interrelationships
      sought relative to internal and external signs of aging. Asteatosis of moderate
      or severe degree, large numbers of scrotal angiomas in men, and retention of nevi
      appeared to be associated with a relatively shortened life expectancy and may be
      signs of decline and approaching death in older individuals.

PMID- 1017304
TI  - Skin cancer.

PMID- 1017305
TI  - Cutaneous ulcers: treatment with gold leaf.

PMID- 1017306
TI  - Sunlight and aging of the skin.

PMID- 1017307
TI  - Foot complaints of the elderly.

PMID- 1017308
TI  - Geriatric hands.

PMID- 1017309
TI  - Permanent hair colorants--vegetable and metallic dyes. Part I: Vegetable.

PMID- 1017310
TI  - Measles and the immune system.

PMID- 1017311
TI  - Surgical management of herpes simplex keratitis.
AB  - The various surgical managements of herpes simplex keratitis are listed. Our
      management is "atraumatic" keratoplasty, if vision is reduced, if the disease is
      protracted, or if perforation occurs. Our preoperative care is aimed at the
      production of a quiet eye with no active virus infection, by the use of antiviral
      drops, steroids, antibiotics, and bandage contact lenses. Removal of all corneal
      disease is desirable, but not mandatory. Perforations are managed in the same
      manner, but the host window is started at the perforation. Postoperative
      management is characterized by the use of therapeutic modalities necessary to
      prevent or treat complications, including steroids and frequent observation to
      check for complications of treatment. Our understanding of herpes simplex virus
      infections as they relate to surgical management is presented. The results of
      treatment warrant continuation of our efforts--but lead to the conclusion that it
      would be most helpful if latent virus infection could be eradicated.

PMID- 1017312
TI  - Pyoderma gangrenosum with carcinoid tumor.
AB  - A patient with the classic lesions of pyoderma gangrenosum was found on autopsy
      to have a carcinoid tumor of the ileum. The simultaneous occurrence of a
      carcinoid tumor with pyoderma gangrenosum is interesting because both conditions
      are associated with immunologic defects.

PMID- 1017313
TI  - Hyperpigmentation problems: effectiveness and rationale of therapy.

PMID- 1017314
TI  - Synthesis of nuclear acidic proteins in mature and immature avian erythrocytes.
AB  - The synthesis of the nuclear acidic proteins in immature and mature avian
      erythroid cells was compared. Synthesis of these proteins was found to occur in
      both types of cells. However, there are quantitative and qualitative differences
      in incorporation of labelled amino acids into the electrophoretic patterns of
      these proteins. There was an overall decline in the specific activity of the
      proteins as erythrocyte maturation proceeds. In particular, one protein band of
      molecular weight 81,000 is predominantly synthesizied in the immature cells but
      not in the mature cells.

PMID- 1017315
TI  - The DNA of Volvox carteri: a biophysical and biosynthetic characterization.
AB  - Various biophysical and biosynthetic characteristics of deoxyribonucleic acid
      (DNA) from Volvox carteri are examined. The DNA from three strains (HK-10,NB-7
      and KA-1) is compared, and all strains are shown to contain at least two distinct
      DNA species which band at densities of 1.714-1.715 and 1.704-1.705 g/cm3 in
      neutral CsCl and correspond to nuclear and "cytoplasmic" DNA, respectively. Base
      compositions calculated from these densities, 55-56% G+C for nuclear DNA, and 45
      46% G+C for cytoplasmic DNA, are in close agreement with % G+C values estimated
      from thermal denaturation data. DNA from strain KA-1 has a third component with a
      buoyant density of 1.693 g/cm3. DNA synthesis is analysed using radioactively
      labelled heterogeneously grown strains of Volvox carteri and profiles obtained
      following preparative CsCl density gradient centrifugation are presented. In
      addition, dissimilarities in patterns of DNA synthesis at various periods in the
      asexual life cycle are reported for synchronous cultures of strain HK-10. These
      differences in temporal patterns of DNA synthesis clearly indicate that while
      nuclear DNA is make to some degree throughout the life cycle, cytoplasmic DNA
      synthesis appears to occur only at discrete intervals.

PMID- 1017316
TI  - Quantitative analysis of human chromosome segregation in man-mouse somatic cell
      hybrids.
AB  - The presumed random and independent process of human chromosome segregation in
      man-mouse somatic cell hybrids was studied. The results of chromosome analysis on
      196 cells from 15 related hybrid strains have provided the first convincing
      evidence that segregation of human chromosomes can be nonindependent and often
      concordant. Different human chromosomes were not retained with equal frequency in
      these hybrid clones. Some were present in 80% of all the cells, whereas others
      appeared in less than 10% of the same cells. Linear regression analysis was used
      to test for correlation of the frequencies of all pair-wise combinations of human
      chromosomes present in these hybrid clones. Twenty-two of 136 possible
      correlations were statistically significant, indicating that concordant
      segregation of particular pairs of human chromosomes is a rather frequent
      occurrence.

PMID- 1017317
TI  - Cytological demonstration of mitotic crossing-over in man.
AB  - Quadriradial (QR) configurations from four different human lymphocyte metaphase
      samples have been analyzed: a patient with Fanconi's anemia; normal female cells
      X-irradiated with 150 or 200 R in S or G2; spontaneous QRs occurring in 13,584
      metaphases; and cells from two sibs with Bloom's syndrome. That mitotic chiasmata
      are caused by crossing-over rather than by random breakage and reunion was
      concluded from the following observations: (1) In the spontaneous sample, mitotic
      chiasmata are about as frequent as all other QRs together. (2) The frequencies of
      mitotic chiasmata and of other QRs are not correlated in the different samples.
      (3) The break points in other QRs are situated at random relative to chromosome
      length, whereas the distribution of chiasmata is highly nonrandom. (4) Although
      the centromeres of chromatid translocations occur in alternate and adjacent
      positions with approximately equal frequencies, there are very few adjacent
      counterparts to mitotic chiasmata. These can best be interpreted as a result of
      an abnormal U-type rejoining of chromatids in a chiasma. (5) Chiasmata found in
      heteromorphic chromosome pairs show that crossing-over has, indeed, taken place.

PMID- 1017319
TI  - Association of the sex chromosomes in meiosis of mouse species.

PMID- 1017318
TI  - Gene dose effect: regional mapping of human glutathione reductase on chromosome
      8.

PMID- 1017320
TI  - Somatic cell hybrid assignment of a structural gene for human beta-glucuronidase
      to chromosome 7 by use of an X/7 translocation.

PMID- 1017321
TI  - Deletion in the short arm of chromosome 9 from a subject with congenital cerebral
      maldevelopment. Repository identification No. GM-870.

PMID- 1017322
TI  - A (2;4) translocation, unbalanced, 46 chromosomes. Repository identification No.
      GM-501.

PMID- 1017323
TI  - A (2;4) translocation, balanced, 46 chromosomes. Repository identification No. GM
      1064.

PMID- 1017324
TI  - A (10;17) translocation, 46 chromosomes. Repository identification No. GM-959.

PMID- 1017325
TI  - [Treatment of congenital scoliosis].

PMID- 1017326
TI  - [Surgical treatment of spondylolisthesis by means of an interbody fusion].

PMID- 1017327
TI  - [Treatment of inveterate congenital hip dislocation by means of hemiarthroplasty
      and muscle elongation].

PMID- 1017328
TI  - [Osteotomy in the correction of a multi-plane and multi-site deformity of the
      lower extremity].

PMID- 1017329
TI  - [Treatment of delayed union and non-union of the long bones and pseudarthroses by
      means of Paltrinieri's method].

PMID- 1017330
TI  - [Treatment of infected pseudarthroses of the tibia].

PMID- 1017331
TI  - [Deformations occurring in an anatomical specimen of the spine at the L4-S1 level
      under the influence of a single and of repeated compression].

PMID- 1017332
TI  - [Heredity as an etiological factor of congenital hip dislocation].

PMID- 1017333
TI  - [Effect of B-12 vitamin on glycogen content in skeletal muscles and liver of rats
      intoxicated with carbon tetrachloride].

PMID- 1017334
TI  - [Spa rehabilitation of patients with spastic paresis].

PMID- 1017335
TI  - [Total stiff hip replacement].

PMID- 1017336
TI  - [Treatment of tetraplegia and paraplegia stemming from old spinal cord lesions].

PMID- 1017337
TI  - [Radioisotopes in the diagnosis and treatment of osteomyelitis].

PMID- 1017338
TI  - [Changes in cat dorsal muscles following spinal deformity caused by rhizotomy].

PMID- 1017339
TI  - [Treatment of scoliosis with metal distractors].

PMID- 1017340
TI  - [Treatment of 2-level fractures of the lower extremitities].

PMID- 1017341
TI  - [Hyperplastic callus in osteogenesis imperfecta].

PMID- 1017342
TI  - [Sanguinary treatment of diaphyseal fractures of the humerus].

PMID- 1017343
TI  - [Our experience with fractures of the humeral diaphysis treated using Rush's
      "closed" dynamic osteosynthesis].

PMID- 1017344
TI  - [Prosthetic replacement in joint tumors].

PMID- 1017345
TI  - [Surgical correction of pronatory and supinatory syndromes of the forearm as
      sequelae of obstetrical paralysis].

PMID- 1017346
TI  - [Partial dissociated paralysis of the radial nerve due to a ganglion of the elbow
      joint].

PMID- 1017347
TI  - [Esthetic and functional prosthesis of the hand].

PMID- 1017348
TI  - [Painful total hip prosthesis examined using radioisotopes (preliminary note)].

PMID- 1017349
TI  - [Focal intervention in Pott's disease : current anesthesiological trends].

PMID- 1017350
TI  - [Osteosynthesis using the Rush nail in fractures of the peroneal malleolus].

PMID- 1017351
TI  - [Jejunum-ileal bypass in the treatment of experimental obesity in the rat. I.
      Surgical technics].

PMID- 1017352
TI  - [Jejunum-ileal bypass in the treatment of experimental obesity in the rat. (II.
      Long-term behavior of some biohumoral parameters)].

PMID- 1017353
TI  - [Morphological and ultrastructural aspects of intestinal mucosa after transileal
      uretero-cutaneostomy (findings 5 years after surgical intervention)].

PMID- 1017354
TI  - [Reduction of lumbosacral spondylolisthesis with major displacement in children,
      using Harrington's instruments followed by intersomatic L5-S1 arthrodesis.
      Apropos of 6 cases].

PMID- 1017355
TI  - [Treatment of gastroesophageal reflux in children].

PMID- 1017356
TI  - [Incontinence after treatment of anorectal inperforations].

PMID- 1017357
TI  - [Colonic esophagoplasty in children. Apropos of 15 cases].

PMID- 1017358
TI  - [Knife wounds of the carotid arteries in their cervical segment. Apropos of 3
      cases].

PMID- 1017359
TI  - Chronobiology in the diagnosis and treatment of mesor-hypertension.
AB  - An elevation of systolic and diastolic bloodpressure to values regarded as
      abnormal ones on the basis of conventional criteria was recognized by self
      measurement. For both systolic and diastolic blood pressure, the overall means
      adjusted for rhythms, the so-called mesors, also were elevated in the light of
      their response to treatment: these mesors were found to be lowered with
      statistical significance when values during treatment were compared by an
      objective test with values measured before treatment. Individualized rhythmometry
      quantitatively characterizes a predictalbe portion of the variability in human
      blood pressure and tests for the statistical significance of changes in blood
      pressure as a function of the treatment and also as a function of the  circadian
      timing of such treatment. The case report thus illustrates an individualized
      chronotherapy of systolic and diastolic mesor-hypertension, diagnosed
      retrospectively from the tested effect of hydrochlorothiazide. In the case
      reported, and perhaps routinely, computer-analyzed self-measurements can serve 1)
      to prescribe the right kind and amount with the right timing, for a given
      therapy, and 2) for diagnosis and prevention as well (Meyer et al.; Halberg et
      al.).

PMID- 1017360
TI  - Evidence for a circadian oscillation in the gonadal response of the tropical
      weaver bird (Ploceus philippinus) to programmed photoperiod.
AB  - The effect of an asymmetrical skeleton photoperiod scheduleee was studied on the
      gonadal development in a tropical finch, the weaver bird (Ploceus philippinus).
      The schedul comprised a short nonstimulatory primary photoperiod of 6 hrs and a
      secondary  much shorter lightperiod given as a 15-min light pulse at different
      times in the dark period. The light pulse 11 hrs after the basic period resulted
      in gonadal stimulation, while light pulse in contimuation with the basic period
      or 8, 14 or 21 hrs after the basicperiod was not stimulatory. The "photoinducible
      phase" was much more precisely outlined by shifting the birds from an 8-h to a 10
      h pulse, and from an 11-h to 12-h pulse and was found to be very short, lasting
      about an hour falling between 11 and 12 hrs after the primary light period. The
      short photoinducible phase may be of an adaptive value since in the tropics the
      difference between the shortest and the longest daylength is also rather small (3
      hrs and 15 min at Varanasi, 25degrees N). Clearly the weaver bird possesses a
      fine time-measuring device involving an endogenous circadian rhythm in
      photosensitivity. In nature, spermatogenesis in this bird also begins in March
      when the daylength exceeds 11 hrs (thus perhaps coinciding with the
      photoinducible phase). In rather small, photoperiod may not serve as a cue to
      trigger seasonal reproductive periodicity, it seems that photoperiod can act as a
      Zeitgeber for the initiation of spermatogenesis in the weaver bird at least.

PMID- 1017361
TI  - The role of pineal and eyes in the photoperiodic effect on the gonad of the
      medaka, Oryzias latipes.
AB  - Studies on gonadal development in the female medaka, Oryzias latipes, intact,
      blinded or blinded-pinealectomized, maintained on different lighting schedules,
      i.e. LD14:10 and LD 10:14 and under natural daylight conditions, revealed that:
      1)blinded fish were capable of responding to annual photoperiodic shifts with
      alterations of gonadal development, if the pineal was left intact; 2)the mean
      gonosomatic index(GSI) was higher in blinded fish than in intact fish, during a
      period from October through April, under LD 14:10, LD 10:14 and the natural
      daylight conditions; 3)when reared under the natural daylight conditions, the
      mean GSI in blinded fish was approximately half of that in intact ones in May and
      June, although the values were significantly larger than those in fish examined
      during all the other seasons; and 4)in December, the mean GSI was larger in
      blinded-pinealectomized fish than in intact and blinded ones. These findings seem
      to indicate that, during the breeding season, the gonadal growth in the medaka is
      stimulated by the pineal blocking the inhibitory mechanism against the
      hypothalamo-hypophyseal gonadotropic system, whereas during non-breeding seasons,
      the gonadal involution is induced by an anti-gonadal factor released by the
      pineal. It is likely that the effects of photoperiods are exerted on the pineal
      through the eyes.

PMID- 1017362
TI  - Sequence determination of proteins with 2-p-isothiocyanophenyl-3-phenylindenone.

PMID- 1017363
TI  - Thiolation of melittin with n-acetylhomocysteine thiolactone and study of the
      structure of oxidated thiolated products.

PMID- 1017364
TI  - Synthesis and physiological activity of certain chloralphenylbiguanides.

PMID- 1017365
TI  - Unified rhythm of the slow wave of the small and large intestines in the
      ileocecal region.

PMID- 1017366
TI  - Desmosome-like structures of the peripheral nerve fibres.

PMID- 1017367
TI  - Renin activity in the prehypertensive and early hypertensive stage of
      spontaneously hypertensive rats.

PMID- 1017368
TI  - Outcome of the California Civil Addict commitments:1961-1972.

PMID- 1017369
TI  - Antecedents of narcotic use and addiction. A study of 898 Vietnam veterans.
AB  - Previous studies of predictors of narcotic abuse have been retrospective and
      based on samples of long-term addicts obtained from legal or medical channels.
      There are several methodological problems in this approach. The present study is
      an attempt to test certain alleged predictors of narcotic use in a cohort of 898
      Vietnam veterans. The design overcomes several of the methodological weaknesses
      of previous studies. Eight variables which have been reported as predictors of
      drug use or addiction in the drug literature were inquired about during a
      personal interview which included the premilitary life of each subject. The
      antecedent variables were socioeconomic background, inner city residence,
      psychiatric illness, broken home, race, employment history, education and
      antisocial history. Using information obtained from interviews and military
      records, we then tested the predictive value of each of these antecedents by
      comparing narcotic used and addiction in Vietman and use after Vietnam in men
      differing with respect to each antecedent. Results indicate that some of the
      variables were very poor, and others very good predictors of the various levels
      of narcotic involvement. The predictive value and overall importance of each of
      the variables we tested are discussed.

PMID- 1017370
TI  - The future of federal drug abuse research. How can we best maximize scarce
      resources?

PMID- 1017371
TI  - Treatment effectiveness as judged by successfully and unsuccessfully treated
      alcoholics.
AB  - Thirty-seven successfully and 46 unsuccessfully treated male alcoholics were
      asked to judge the effectiveness or ineffectiveness of six treatment methods
      routinely offered by a state hospital. For each treatment method, the total
      frequencies of judgments of most and least helpful, respectively, were as
      follows: detoxification (16%, 14%), lectures (16%, 20%), group therapy (54%, 7%),
      individual counseling (26%, 6%), work therapy (17%, 22%) and family therapy (13%,
      14%). The two groups of subjects differed significantly in the frequencies of
      treatment methods judged to be "least helpful", but not in the frequencies of
      "most helpful" treatment. The similarity between the judgments of successfully
      and unsuccessfully treated alcoholics might reflect the positive effects of
      previous treatment in the unsuccessful group.

PMID- 1017372
TI  - Addicts' attitudes toward drugs: a semantic-differential study.
AB  - The Drug Rating Scale, an adaptation of the Osgood semantic-differential
      technique, was devised to measure the connotative aspects of attitudes toward
      drugs. Sixty-two heroin-addict clients and fourteen staff members of the Haight
      Ashbury Free Medical Clinic completed the Scale. The Addict group tended to
      regard heroin in a negative light, possibly consistent with their own lack of
      self-esteem. Amphetamines and LSD had the greatest distance from heroin in the
      addicts' "semantic space"; this was consistent with addicts' relative preference
      for alternative drugs to heroin. The evaluative and activity dimensions provided
      a plausible assignment of the eight drugs inquired about into four quadrants.

PMID- 1017373
TI  - Reassessing the goal of drug education: diversity of preference among teachers
      and students.
AB  - Most of the proponents of drug education assume that the primary objective of
      such programs is to deter student drug use. To test this assumption,
      administrators, students and teachers from six public school districts were
      surveyed about what they thought the primary role of the school should be. While
      most administrators and teachers thought that the school's role should be limited
      to developing responsible attitudes or providing drug information, students
      selected a more diverse set of objectives for the schools. The policy
      implications of these findings are discussed.

PMID- 1017374
TI  - Metabolic disposition of 2-phenylethylamine and the role of depression in
      methadone-dependent and detoxified patients.
AB  - We have now postulated that differences in the innate capacity of individuals to
      synthesize, store and utilize biogenic amines may provide the biological basis
      for human abuse of narcotic and other drugs, and that these drugs are used in an
      apparent unconscious effort to self-medicate against an inherent affective
      disorder. In this communication, we attempted a preliminary characterization of
      the narcotics withdrawal syndrome on biochemical and clinical parameters.
      Abstinence was found to be characterized by low urinary excretion of 2
      phenylethylamine and depression. An indication for use of tricyclic drugs has
      been discussed.

PMID- 1017375
TI  - Neurological assessment of patients on prolonged methadone maintenance.
AB  - Medical histories, neurological examinations and electroencephalograms of 25
      methadone-maintained subjects were compared with those of 25 abstinent controls.
      Comparisons on all measures failed to show significant differences between
      groups. The incidence of abnormalities was low for all subjects. None of the
      observed conditions appeared to involve methadone in their etiology.

PMID- 1017376
TI  - Effects of methadone on alcohol consumption and growth in mice.

PMID- 1017377
TI  - Clinical pharmacological studies with 6-azidomorphine.
AB  - The intravenous (i.v.) administration of 4 mug/kg 6-deoxy-6-dihydroazido
      isomorphine (6-AM) base to healthy, young adult male volunteers caused no
      circulatory and relatively little, short-lasting respiratory depression. Of the
      ten volunteers all felt lightheaded, two became euphoric and when they became
      ambulatory at the end of the experiment, three vomited and two other became
      nauseated. The intramuscular (i.m.) administration of the same dose of 6-AM had
      considerable analgesic effect against various types of experimental pain. It was
      more effective against ischemic pain, than against pain induced by electrical
      stimulation of the earlobe or the tooth pulp and it effected severe pain more
      than mild or moderate pain. In the six subjects investigated, 6-AM produced
      significant myosis. Of the 16 subjects who received 4 mug/kg 6-AM i.m. five
      experienced mild euphoria, two felt lightheaded, six became pale and sweaty in
      the course of the experiments carried out in the sitting position. When they
      becam ambulatory after the completion of the experiments, two subjects vomited
      and six others became nauseated. The findings of this study indicate that 6-AM
      causes less circulatory and respiratory depression than is to be expected from
      equianalgetic doses of morphine. Its other side effects (e.g., nausea, vomiting)
      are also less frequent and severe than those encountered after the administration
      of comparable doses of morphine to ambulating volunteers.

PMID- 1017378
TI  - Seven attitude scales used in assessing cannabis use amongst students.
AB  - A number of newly constructed attitude measures are described and correlated with
      two previously established measures, on a sample of 830 university students.
      Scales were devised to measure political orientation, permissive-restrictiveness,
      puritan ethic, parental congruence and extra-intra punitiveness. In addition a
      checklist concerned with degree of social and political activity, a modified
      (shortened) version of Crumbaugh's Purpose in Life Test, Srole's Test of Anomie
      (complete), and the shortened form of the E.P.I. were used. Item loadings on the
      main facotr in each scale and overall correlations between the scales are given.

PMID- 1017379
TI  - Neuronal depletion in the globus pallidus of heroin addicts.
AB  - Decreased neuronal population densities are described in the globus pallidus of
      narcotic addicts. Toxicologic studies indicate mixed addiction to be frequent,
      but exposure to parenteral heroin is the only common factor. This permanent brain
      damage seems more likely to be caused by recurrent episodes of hypoxia during
      severe reactions to narcotics than to be related to direct neurotoxic effects of
      heroin. The lesion may account for some of the long term changes observed in
      addicts.

PMID- 1017380
TI  - Motivation for alcohol in rats: position and bottle preferences do not cause
      drinking.
AB  - Position preference, i.e., the tendency to drink from onelocation rather than the
      other, was found to be relatively unimportant in determining the drinking
      behavior of rats presented with a choice between water and a 7% (v/v) ethanol
      solution in typical two-bottle choice situations. It accounted for essentially
      none of the variance in rats generally drinking more alcohol solution than water
      after prolonged previous alcohol experience, and in rats consuming very little
      alcohol; only in rats drinking slightly less alcohol solution than water was it
      found to have an influence. Similarly, bottle preference, i.e., the tendency to
      drink from one of the two bottles regardless of its position or contents,
      andposition preference were found to have almost no effect on heavy-drinking rats
      even on their first day of exposure and on low-drinking rats after about three
      days of access to alcohol.

PMID- 1017381
TI  - The drinking habits of residents of a rehabilitation program with a controlled
      drinking option: a preliminary report.
AB  - Residents of an alcoholism rehabilitation program with a controlled drinking
      option were asked to give daily reports on their drinking. Program staff were
      also asked to report evide-ce of resident drinking. A comparison of information
      from these two sources showed, among other things, that residents were generally
      reluctant to report drinking which was proscribed the the program. Such drinking
      as was reported varied from isolated, non-problematic, small quantity drinking,
      to heavy, regular and problem-producing drinking. In general, residents' drinking
      did not prevent them from work while in residence. The men's reluctance to report
      proscribed drinking is seen as largely accounted for by the system of fines for
      intoxication and drinking without rights. It is concluded that it would be
      premature to recommend the program's drinking policies to other residential
      programs, but future experimentation is indicated.t is concluded that it would be
      premature to recommend the program's drinking policies to other residential
      programs, but future experimentation is indicated.

PMID- 1017382
TI  - Radioimmunoassay of amphetamines in rat parotid saliva.
AB  - Amphetamines, a commonly abused class of drugs, have been detected in various
      biological specimens, in particular, urine and blood. However, little information
      is available concerning the detection of these drugs in saliva. This
      investigation, utilizing the rat salivary secretions, has been attempted to
      establish the ability of amphetamines to be secreted in saliva and to determine
      the feasibility of using radioimmunoassay (RIA) for drug detection in saliva. The
      results of this investigation showed that (1) d-amphetamine and methamphetamine
      decreased salivary flow, (2) after d-amphetamine RIA tests were demonstrated in
      both saliva and plasma for a period of fifty minutes, and (3) positive RIA
      reactions were obtained by the following metamphetamine metabolites: amphetamine,
      4-hydroxynorephedrine and 4-hydroxyamphetamine. Methamphetamine and 4-hydroxy-N
      methylamphetamine were found to be non-reactive in the radioimmunoassay
      procedure. The results indicate that saliva could be radioimmunoassayed for the
      detection of amphetamine or amphetamine derivatives after the administration of
      either d-amphetamine and methamphetamine.

PMID- 1017383
TI  - A sociological theory of the diffusion and social setting of opiate addiction.
AB  - The theory presented here is intended to apply to socially deprived areas where
      heroin addiction is endemic, narcotics are available, and adolescents are not
      naive about the consequences of heroin use. In such settings rapid epidemic
      changes occur in which within a short period of time large numbers are involved.
      The transition of heroin use is a conversion-type phemonenon which is facilitated
      by the basic belief system, the network of social circles and the social and
      psychological inducements for compliance.

PMID- 1017384
TI  - Experiences of a methadone detoxification programme for opium addicts.
AB  - The conduction of a new programme of methadone detoxification of opium addicts in
      a general hospital setting is described. A blind technique of dispensing
      methadone in a powdered form mixed with powdered aspirin to two groups of opium
      addicts was used: Group A were given a gradual reduction of the methadone over a
      period of ten days, while group B were maintained on the initial stabilising dose
      for the ten days and then abruptly withdrawn from methadone on the eleventh day.
      It was observed that the number of complaints and abstinence symptoms was
      markedly reduced in Group B. It is suggested that this technique is a major
      improvement over the standard progressive reduction method of methadone
      detoxification. A follow-up of these patients over a period of 1 1/2 years is
      reported.

PMID- 1017385
TI  - The impact of methadone and drug-free treatment on criminal behavior.
AB  - The present study was initiated to evaluate the effect of methadone versus drug
      free treatment on a series of criminal involvement measures. A 50% random sample
      of the 776 clients who had registered with the Central Intake Unit over a one
      year period was selected for intensive study. Data were collected through
      examination of intake and treatment files for pre- and post-admission time
      periods. Arrest, conviction and incarceration rates as well as correctional
      status were measured and compared across pre-treatment, intake and three month
      post-intake periods. The arrest rate for the total sample decreased radically
      from 92.8% upon entering treatment to 8% after three months in treatment. The
      subsequent rates at 6, 9 and 12 months decreased in a fairly consistent manner.
      This trend was similar in the methadone, drug-free, and methadone/drug-free
      groups for either arrests, convictions or incarceration rates with time in
      treatment. The relationship between arrests and employment and drug use was also
      examined. No association was found between use of opiates as measured by
      urinalysis results and frequency of arrest. Similarly, arrest rates showed no
      significant association with employment rates during the first nine months of
      treatment, although the comparison at twelve months was significant with only
      16.7% of those employed clients being arrested.

PMID- 1017386
TI  - Drug abuse: a manifestation of the cyclic nature of human behavior.
AB  - The authors conclude that a cyclic pattern of drug use behavior can be documented
      in a given population. While such a study provides a microcosmic view of such
      behavior, it is postulated that this same cyclic pattern was experienced in the
      macrocosm of society at large by drug-abusing populations over centuries past.

PMID- 1017387
TI  - A study on the personality characteristics of Iranian addicts.
AB  - The present study was undertaken to investigate the personality characteristics
      of addicts in Iran and to investigate the applicability of the Persian version of
      the Manson Evaluation Scale in a sample of 107 hospitalized male addicts as
      compared with a group of 90 non-addicts. All MES values attained statistically
      significant t-value at or better than 0.01 level of confidence between the two
      groups. The study supports findings in Western socities except that our sample
      exhibits psychoneurotic traits more than psychopathic trends.

PMID- 1017388
TI  - Chronic polyarthritis at the Kenyatta National Hospital.

PMID- 1017389
TI  - The misdiagnosis of chronic constrictive pericarditis.

PMID- 1017390
TI  - Multiple myelomatosis in Ibadan: a comparative study.

PMID- 1017391
TI  - Tabes dorsalis: two case reports.

PMID- 1017392
TI  - Some aspects of public health and medical care in China (Challenges to developing
      countries).

PMID- 1017393
TI  - Teaching hospitals and their administration in developing countries: suggestions
      for future improvement.

PMID- 1017394
TI  - Actions of morphine and sympathomimetic amines on isolated chick oesophagus.

PMID- 1017395
TI  - Pericardial effusion in childhood endomyocardial fibrosis.

PMID- 1017396
TI  - The pattern of adult medical admissions in Addis Ababa, Ethiopia.

PMID- 1017397
TI  - Pain relief in labour using methoxyflurane.

PMID- 1017398
TI  - Blood glucose values in healthy full-term African newborn infants during the
      first 28 days of life.

PMID- 1017399
TI  - Bleeding disorder in three male siblings.

PMID- 1017400
TI  - Acute leukaemia in pregnancy. A case report from the Kenyatta National Hospital.

PMID- 1017401
TI  - Poisonous snake bite--a reappraisal.

PMID- 1017402
TI  - Notes on antibiotic usage in the Netherlands.

PMID- 1017403
TI  - [Influence of poisoning on the liver and intestines].

PMID- 1017404
TI  - [Primary malabsorption syndrome in the adult].

PMID- 1017405
TI  - [Calciphylactic pancreatitis and immunology].

PMID- 1017406
TI  - [Influence of therapy on glucose and lipid metabolism as well as insulin
      secretion in diabetes mellitus].

PMID- 1017407
TI  - [Possibilities for information processing and operations simplification in
      multidimensional tasks of morphokinetic synthesis].
AB  - The authors propose an iterative method for separating classes of objects by
      reduction of multidimentional space of sings, which describe objects by
      twodimentional space of two integral processings of the differences between
      sings. For this purpose the differences are evaluated by three steps rating:
      positive difference, negative difference and no difference. The proposed
      iterative algorhythm allows by finite and a small number of procedures to remove
      indeterminace which in the general case is contained in the so defined on the
      work integral processings. The application of the algorhythm does not require a
      special mathematical training. Represantation of the objects by integral
      characteristics is made in twodimentional space. In the paper the report the
      authors give a generalization for the case of M-steps rating for evaluation of
      the differences between the signs of the objects.

PMID- 1017408
TI  - [Morphologic characteristics of carbon tetrachloride poisoned liver in the
      presence of iron loading].
AB  - The author examined the influence of abnormal amounts of iron on the development
      of early fibrosis (14th day), early and advanced cirrhosis (45th and 90th day) in
      liver esperimentaly damaged by carbon tetrachloride by means of morphological and
      histochemical methods. On the basis of the obtained data she could suggest that
      while at early stages iron did not have significant influence on the rate of
      development and gravity of the pathologic process, later (advanced cirrhosis) the
      changes were less manifested. She asumed that three valence iron, administered in
      the organism of the animals intoxicated by carbon tetrachloride, improved the
      course of the metabolic processes in the damaged liver cells, a manifestation of
      which was later and weaker development of the cirrhotic process.

PMID- 1017409
TI  - [Structuro-functional parallels in several liver lesions in rats resulting from
      dietary protein deficiency].
AB  - The authors examined 60 white rats of the Wistar strain with initial age of four
      monts and weight of 200 -- 15 gm, subjected to deficient food regime with varous
      protein content (5.74%, 11.48%, but the control was 17.50% of protein) for a
      period of 16 weeks. After this period half of the animals were stimulated by an
      antigen -- 10% of human gamma globulin. They determined total protein and protein
      fractions in serum, histological changes in liver and some morphometric indices.
      It was established that there was a correlation between the level of serum
      proteins and the observed changes in liver parenchyma and mesenchyma, in which
      the factor "protein deficit" had significantly greater effect than the factor
      "heterologous serum protein" as an antigenic stimulus.

PMID- 1017410
TI  - [Changes in myocardial activity of several enzymes of glycolysis, the
      tricarboxylic acid cycle and pentosephosphate shunt in rats with experimental
      hypertension].
AB  - The authors examined dynamicaly from the third day to the third month the
      activity of enzymes, participating in glycolysis (ALD, PK, LDH),
      pentosemonophosphate shunt (G6P-DH), citric cycle (MDH, INDH) in the myocardium
      of rats with hypertension, induced by the method of Selye, modified by Kolarova.
      There were phase changes in enzymatic activity in the myocardium, manifested at
      the first stages by lowering (LDH, ALD, INDH) or elevation (MDH, PK, G6-DH). The
      activity of all examined enzymes was over that of the control group on the
      thirteenth day, while there were also oscillations on the nineteenth day. Only
      the actimity of G6-DH revealed a progressive elevation during the whole
      experimental period. The changes in the enzymic activity of the myocardium at the
      first stages were interpreted as a sign of nonspecific adaptation to the changed
      conditions of heart activity. The later changes were manifestations of the
      disturbances at various metabolic links, which were unevenly involved in the
      processes of myocardial hypertrophy.

PMID- 1017411
TI  - [Effect of preparation TB-68 on spermatopoiesis in rats (autoradiographic
      study)].
AB  - Male mature rats were treated per of with TB-68 and intraperitonealy with 3H
      thymidine during 7 and 12 days. By means of statistical count of labelled cells
      in semi niferous tubules a considerable increase of DNA replicating cells in
      experimental animals was established. The higher percentage of labelled calls
      reveales an stimulating effect of TB-68 concerning the spermatogonial
      proliferation, some acceleration of the meiosis and positive influence of the
      spermatopoiesis as a whole.

PMID- 1017412
TI  - [Effect of arpenal on the EMG-potentials of the anterior tibial muscle in cats
      during acute phosdrine poisoning].
AB  - The authors examined the changes in the nerve-muscular conductivit occuring after
      acute poisoning with phosdrine and treatment with arpenal and oximic
      reacytivators of HE-toxogonine and TMB-4 on 20 cats, anesthethised with urethane
      and atropine protection under the conditions of artificinal respiration. They
      found that there was a total nerve-muscular block cessation of the mediation in
      the myoneural synaptic zones, characterized by complete cessation also of the
      induced electrical responses after single and serial stimuli, during acute
      intoxications with phosdrine, used in lethal doses of 300 mg/kg intramuscularly.
      After treatment with H-cholinolitics (arpenal) there was a quick recovery of the
      muscle contractions as well as of the evoked myopotentials after stimulation with
      single electric stimuli. In contrast to the oximnic reactivators of He
      (toxogonine, TMB-4) during serial electric stimuli (10,20 and 30 per second after
      treatment with arpenal there was a quick contraction only after the first
      stimulus, after which a progresive weakening of the induced electric
      myopotentials followed till the appearence of a total nerve-muscular block. This
      phenomenon was explained by the lack of reactivating properties of H
      cholinolitics to HE, inhibited by FOV.

PMID- 1017413
TI  - [Rheographic method of determining cardiac strok volume in an acute experiment].

PMID- 1017414
TI  - Target organ toxicity: lung introduction.

PMID- 1017415
TI  - Physiologic basis and interpretation of common indices of respiratory mechanical
      function.
AB  - Tests of pulmonary mechanical function may be used in determining the prominent
      site of pulmonary reaction to intervention. Responses may be localized from a
      knowledge of changes in lung resistance and compliance. A peripheral airway or
      parenchymal response is characterized by a decrease in lung compliance. A central
      airway reaction is characterized by an increase in pulmonary resistance. In mixed
      reactions both parameters may change. In this communication some of the
      physiologic determinants of pulmonary resistance and compliance are discussed and
      examples of localized responses given.

PMID- 1017416
TI  - Role of metabolic activation in the pathogenesis of chemically induced pulmonary
      disease: mechanism of action of the lung-toxic furan, 4-ipomeanol.
AB  - Many xenobiotics produce hepatic injury due to their metabolism in the liver to
      highly reactive electrophile intermediates which form covalent conjugates with
      nucleophilic cellular constituents. This presentation describes studies
      indicating that the production of chemically reactive metabolites by pulmonary
      metabolism of xenobiotics can also play a fundamental role in the pathogenesis of
      chemically induced lung disease.

PMID- 1017417
TI  - Paraquat toxicity: proposed mechanism of action involving lipid peroxidation.
AB  - The purpose of this study was to investigate the hypothesis that paraquat
      pulmonary toxicity results from cyclic reduction-oxidation of paraquat with
      sequential generation of superoxide radicals and singlet oxygen and initiation of
      lipid peroxidation. In vitro mouse lung microsomes catalyzed an NADPH-dependent,
      single-electron reduction of paraquat. Incubation of paraquat with NADPH, NADPH
      cytochrome c reductase, and purified microsomal lipid increased malondialdehyde
      production is a concentration dependent manner. Addition of either superoxide
      dismutase or a single oxygen trapping agent 1,3-dipheylisobenzo furan inhibited
      paraquat stimulated lipid peroxidation. In vivo, pretreatment of mice with
      phenobarbital decreased paraquat toxicity, possibly by competing for electrons
      which might otherwise reduce paraquat. In contrast, paraquat toxicity in mice was
      increased by exposure to 100% oxygen and by deficiencies of the antioxidants
      selenium, vitamin E, or reduced glutahione (GSH). Paraquat, given IP to mice, at
      30 mg/kg, decreased concentrations of the water-soluble antioxidant GSH in liver
      and lipid soluble antioxidants in lung. Oxygen-tolerant rats, which hae increased
      activities of pulmonary enzymes which combat lipid peroxidation, were also
      tolerant to lethal doses of paraquat as indicated by an increased paraquat LT50.
      Furthermore, rats chronically exposed to 100 ppm paraquat in the water had
      elevated pulmonary activities of glucose-6-phosphate dehydrogenase and GSH
      reductase. These results were consistent with the hypothesis that lipid
      peroxidation is involved in the toxicity of paraquat.

PMID- 1017418
TI  - Secretory cells of the peripheral pulmonary epithelium as targets for toxic
      agents.
AB  - The extracellular lining of the pulmonary peripheral airways is of vital
      importance to the lung. In this report, some aspects of the pulmonary
      extracellular lining and the epithelial cells believed to be responsible for its
      formation and secretion have been briefly reviewed. The influence of a number of
      toxic agents on the extracellular lining either directly or via those cells
      involved in its formation indicates that the extracellular lining may be
      important in understanding numerous toxic agent interactions with the lung.

PMID- 1017419
TI  - Overview: recent developments in the toxicity of environmental oxidants.

PMID- 1017420
TI  - Inhalation exposure of animals.
AB  - Relative advantages and disadvantages and important design criteria for various
      exposure methods are presented. Five types of exposures are discussed: whole-body
      chambers, head-only exposures, nose or mouth-only methods, lung-only exposures,
      and partial-lung exposures. Design considerations covered include: air cleaning
      and conditioning; construction materials; losses of exposure materials; evenness
      of exposure; sampling biases; animal observation and care; noise and vibration
      control, safe exhausts, chamber loading, reliability, pressure fluctuations; neck
      seals, masks, animal restraint methods; and animal comfort. Ethical
      considerations in use of animals in inhalation experiments are also discussed.

PMID- 1017421
TI  - An isolated perfused rat lung preparation.
AB  - An isolated perfused rat lung preparation (IPL) is described and its physiologic
      status is evaluated. The evaluation includes light and electron microscopy after
      perfusion and estimations of substrate utilization. ATP content, lactate
      production, and incorporation of glucose carbons into lipids and CO2. It is
      concluded that the IPL is useful for short-term metabolic and physiologic
      experiments and offers some unique advantages in evaluating effects of reactive
      gases upon lung function.

PMID- 1017422
TI  - Studies on the uptake, metabolism, and release of endogenous and exogenous
      chemicals by use of the isolated perfused lung.
AB  - The isolated perfused lung is a valuable tool for studying many lung functions.
      The kinds of information one can obtain from the isolated perfused lung are
      illustrated by examples from our studies on the uptake, accumulation, and
      metabolism of endogenous and exogenous chemicals.

PMID- 1017423
TI  - Use of tracheal organ cultures in toxicity testing.
AB  - Fragments of tracheal epithelium alone or in continuity with connective tissues,
      can be maintained in culture medium and used for short term or long term studies
      of toxicity of a variety of chemicals. Large numbers of uniform cultures are
      prepared with the aid of a slicing device or by application of simple method for
      dissecting sheets of epithelium free from underlying cartilage. The cultures may
      be placed in an exposure chamber-incubator mounted on a microscope stage and
      monitored continually for ciliostasis and exfoliation of cells. Morphology is
      further studied by fixation of selected specimens and preparation for light
      microscopy and electron microscopy. Synthetic functions are evaluated by
      autoradiographic measurement of incorporation of radioactive precursors into
      macromolecules and other dynamic features are indirectly assessed by
      histochemical and histoenzymatic methods. Short-term studies using these several
      techniques have shown that ciliostasis does not correlate with cell injury in all
      instances, and a long-term study has demonstrated dose dependence of a cytotoxic
      agent when duration of culture viability is measured. The method lends itself to
      a broad range of investigations in which dose, period of exposure, and role of
      cofactors must be independently and quantitatively assessed.

PMID- 1017424
TI  - Biochemical studies of isolated hamster tracheal epithelium.
AB  - The epithelial lining of respiratory air passageways is a primary target tissue
      for toxicity and carcinogenesis in man and in animal models of human disease. The
      importance of this target tissue was the basis for development of methods to
      study its biochemistry, and with this information to distinguish the unique
      properties of this tissue from properties common to all cell types. Biochemical
      methods employed labeling of macromolecules in isolated hamster treacheas during
      brief (less than 4 hr) incubation in vitro. Studies of RNA metabolism in isolated
      tracheas demonstrated a pattern of maturation of ribosomal RNA like that shown
      for other cell types. Alterations in RNA metabolism were observed in isolated
      tracheas obtained from vitamin A-deficient hamsters and hamsters previously
      treated by intratracheal administration of benzo[a]pyrene (BP) plus ferric oxide
      (Fe2O3) in vivo. Studies with toyocamycin, actinomycin D, and alpha-amanitin, all
      inhibitors of RNA metabolism, were performed to characterize the class of RNA
      molecules with a decreased proportion of labeling in tracheas from vitamin A
      deficient hamsters. In another series of experiments, BP was shown to bind to DNA
      in epithelial cells of isolated tracheas. The quantity of BP binding was
      increased by prior intratracheal treatment of hamsters with BP plus Fe2O3 in
      vivo, this induced binding was inhibited by addition of 7,8-benzoflavone to the
      incubation medium. Increased BP binding was also observed in isolated tracheas
      from hamsters believed to be in states of increased susceptibility to respiratory
      carcinogenesis in vivo. The results show that biochemical studies are feasible
      with this tissue. Furthermore, a number of questions of importance with regard to
      this target epithelium are best studied directly in its constituent cells.

PMID- 1017425
TI  - Labelling and metabolism of methionine-methyl-11 C.
AB  - Carbon 11 which is a 20.4 minutes half life isotope emitting positrons was used
      for methionine labelling on the methyl group by action of 11C-methyl-iodide on DL
      or L homocysteine. With the method described, 20 to 30 mCi of 11C-methyl
      methionine (Specific activity 50 mCi/muM) may be obtained within 25 minutes. The
      20 Mev proton beam used for 11C production was 10 muA. The metabolism of 11C
      methionine studied on mice shows a high uptake in pancreas and to a smaller
      extent in brain. On humans sequential images were obtained at the head level
      which allowed measurement of the uptake of the radio-labelled compound in the
      brain so as to study the radioactivity curve in different parts of the organ.

PMID- 1017426
TI  - Experience with 201 thallium in detection of myocardial infarction.
AB  - Our preliminary experimental and clinical results with 201Tl myocardial scanning
      are presented. 48 patients with normal coronary vessels, acute trasmural
      myocardial infarction, localized and diffuse coronary heart diseases and
      congestive myocardiopathy were investigated. Results of scans and the usual
      cardiological investigations were in good agreement thus justifying further use
      of 201Tl myocardial scintigraphy as an adjunctive method in cardiology.

PMID- 1017427
TI  - The uptake of gallium 67 in colonic macrophages.
AB  - A case is presented in which a patient with a well-differentiated adenocarcinoma
      showed high gallium concentration in the segment with melanosis coli proximal to
      the obstruction. Although in this case the Gallium was associated with an
      increased number of faecal pigment containing macrophages it is unlikely that
      macrophages are the main factor in tumour uptake of Gallium compounds.

PMID- 1017428
TI  - Technetium-99m-sulfur colloid. In vitro studies of various commercial kits.
AB  - The quality of five commercial 99mTc-sulfur colloid kits was compared. A number
      of chemical parameters, which characterize the colloids, was used in order to
      study the influence of variations in the preparation procedures and storage of
      the final products. The differences between the kits could mainly be referred to
      the order of addition of the reagents. The quality was generally unaffected by
      variations in time-intervals during preparation. However, a certain heating time
      was necessary for optimal labeling. Variations in quantities of acid and buffer
      were found to influence the particle size as well as the content of unreacted
      pertechnetate. No deterioration in quality by storage was observed; on the
      contrary in some cases the content of free activity decreased.

PMID- 1017429
TI  - Specificity of immunoassays. I. Effect of plasma proteins on the specificity of
      steroid immunoassay.
AB  - The theory of the measurement of the specificity of antigen binding by antibodies
      is reviewed. The specificity of steroid immunoassay has been investigated using a
      new solid phase radioimmunoassay system. The effects of plasma proteins on the
      specificity of the immunoassays have been tested. The methods used and the
      conclusions reached have been tested with homogeneous antibodies in order to
      simplify the interpretation of the results obtained. A new criterium of antibody
      homogeneity is proposed. The importance of correcting all results accurately for
      "non-specific binding" is emphasised. A new method for plotting radioimmunoassay
      standard curves is presented.

PMID- 1017430
TI  - Trace elements analysis in biological samples by radioisotopic x-ray
      fluorescence.
AB  - The X-ray fluorescence technique, induced by radioisotopic sources, provides a
      very simple method for the simultaneous analysis of trace elements in biological
      samples. For blood, serum, platelets, etc., samples of about 0.1 ml were
      deposited on filter paper disks, dried, and analyzed. In such a way the "thin
      specimen" approximation is realized, resulting in the following advantages: The X
      ray intensity of a given element is a liner function of mass per unit area over
      several orders of magnitude. Interelement effects became negligible. The ratio of
      fluorescent X-rays to scattered radiation is increased. The sensitivity of the
      technique for elements with atomic number ranging from about 20-92 varies from
      some units to some tens of parts per million by weight in 100 s measuring time,
      by using a gas proportional counter, and from about some tenths to some parts per
      million by using an X-ray semiconductor detector, in a measuring time of 10(3)
      10(4)s. In such a way and with the described features, the Cl, K, Ca, Fe, Cu, Zn,
      Br content of several speciments of blood and serum was determined. Measurements
      were further carried out in order to labelling blood components with stable
      tracers and to detect their concentration by means of the X-ray fluorescence
      technique. The life span of platelets was, for example, measured after labelling
      platelets with stable Selenocystine. The sensitivity of the XRF technique can
      further be enhanced by about three orders of magnitude by using a pre-enrichment
      step with ion-exchange resins and liquid volumes not lower than 500 ml. Urine
      analyses have been carried in such a way, and copper in about 20 ml serum after
      selective extraction.

PMID- 1017431
TI  - Radioisotope X-ray fluorescence technique in the dynamic study of thyroid
      behaviour under iodine load.

PMID- 1017432
TI  - A rational approach toward determining the candidacy of the prostatic cancer
      patient for cryoimmunotherapy: an interim report.
AB  - While receiving only cursory attention compared to that of other malignant
      neoplasms, studies of patients with prostatic cancer have suggested that host
      responses, mediated in part by immunobiologic factors, may play a significant
      role in the pathogenesis and thus, the therapeutic management of this disease.
      For nearly a decade cryosurgery has gradually attained some degree of acceptance
      as one of the efficacious treatment modalities available in the therapeutic
      armamentarium for prostatic cancer. In addition to the localized destruction of
      the primary tumour, reports of secondary tumour cell destruction, i.e. of distant
      metastases, have supported the suggestion that cryosurgery, as documented in
      various animal species, may also be immunopotentiating in man. Although our
      understanding of immunopotentiation of the host's response to tumour via
      cryosurgery is far from complete, information derived from experimental studies
      demonstrating that the developement of an immunologic response following
      cryosurgery of the prostate may be attributed to androgenically and ontogenically
      dependent autoantigens may have clinical relevance. This together with knowledge
      that in the therapeutic management of the patient with prostatic cancer we are
      confronted with the treatment of an individual who, in the majority of cases,
      possesses waning immunocompetence, emphasizes the potential significance of
      evaluating what may be referred to as the 'cryosensitivity' of the prospective
      cryosurgical patient. At present this 'cryosensitivity' may be said to be
      dependent upon: (1) concentration of prostatic tissue [secretory(tumour?)]
      specific or tumour-associated auto-(neo?) antigen(s); (2) physiologic state
      (elaboration of androgen), and (3) immunocompetence. It is hopeful that
      evaluation of these parameters may provide a rational approach toward determining
      the acceptability of cryosurgery as the treatment of choice in a given patient.

PMID- 1017433
TI  - Inactivation of 5-fluorouracil by the liver during continuous regional and
      systemic infusion in pigs.
AB  - During continuous systemic or portal infusion of 5-fluorouracil (5-FU) to
      anaesthetized pigs, the cytostatic activity was reduced in blood traversing the
      liver. The liver eliminated between 15 and 50% of the amount 5-FU given per time
      unit. During jugular infusion the concentration of cytostatic compounds in portal
      blood was equal to or less than in systemic blood. The cytostatic activity was
      much higher in portal blood and lower in systemic blood during portal infusion.
      The findings speak in favour of portal infusions of 5-FU to patients with
      disseminated cancer in the liver.

PMID- 1017434
TI  - The effects of transections on the basic electrical rhythm in the canine jejunum.
AB  - The basic electrical rhythm (BER) was studied in situ in the jejunum in 14
      anaesthetized mongrel dogs by the mean six monopolar electrodes. The BER
      frequency was measured in the intact intestine and after proximal and distal
      transections of the gut 5 cm apart from the electrodes. No significant
      differences were found between the BER frequencies recorded by each electrode,
      demonstrating the existence of a frequency plateau which remained after each
      transection. In the intact intestine the frequency in the plateau was 13.2 +/-
      0.3 cpm2. After the proximal transection, this frequency dropped to 12.0 +/- 0.4
      cpm (p less than 0.05) and, after the distal transection, it dropped to 10.9 +/-
      0.4 cpm (p less than 0.005). This last frequency change shows the influence of
      the distal intestine on the electrical behaviour of the jejunum.

PMID- 1017435
TI  - Survival in burned mice after treatment with tryglycylvasopressin.
AB  - Standardized skin burn injuries were induced in 253 NMRI mice. The burned surface
      corresponded to 15% of the total surface of a 25-gram mouse. All animals received
      intraperitoneal injection of an isotonic saline solution in a dose of 20% of body
      weight/day for 5 days. The material was divided into three groups, i.e. group A
      (controls) which received no further treatment, groups B and C which, in
      addition, received triglycylvasopressin (a vasopressin with prolonged effect) 100
      and 200 mug/kg body weight, respectively, subcutaneously twice a day. The highest
      survival rate was registered in group B (61%), while the controls had a survival
      of 36%.

PMID- 1017436
TI  - Pancreatic metabolic rate measured in vivo with heat-accumulation technique.
AB  - This study is the first attempt to apply the heat-accumulation technique for
      metabolic studies to the pancreas. The initial temperature rise during arterial
      occlusion was measured with thermocouples sutured into the pancreas of seven
      anaesthetized pigs. Temperature recording were obtained during alterations of the
      metabolism induced by infusions of 2,4-dinitrophenol (DNP) and sodium cyanide
      (NaCN) into the pancreatic head. DNP 2.0 mg/min almost doubled, and NaCN 0.6
      mg/min reduced the heat accumulation rate to one half of control. In four pigs
      the metabolism was estimated by measurements of oxygen consumption in an isolated
      in situ preparation of the pancreatic head. Median metabolic rate in the
      unstimulated gland was 0.09 cal/cm3-min. Metabolic rate estimated by heat
      accumulation technique in a similar situation was 0.11 cal/cm3-min. The method is
      considered useful for evaluation of relative variations of pancreatic metabolism.

PMID- 1017437
TI  - Memory and blood pressure in the aged.
AB  - Memory loss, as measured by the Wechsler Memory scale was examined as a function
      of diastolic blood pressure during a 6.5-year follow-up period among individuals
      initially tested in their 60's. On the initial testing, memory was not related to
      blood pressure. At the end of the follow-up period, the hypertensives showed
      greater impairment in memory for nonverbal material involving time limits and a
      psychomotor component than did their age peers with normotensive and borderline
      elevations of blood pressure. The hypertensives' poor performance, however, was
      found only on specific sub-task items and appeared not to be influenced by item
      difficulty alone but rather by other performance factors such as difficulty in
      deciding what to do, understanding test instructions, or state anxiety associated
      with the testing situation. Memory for highly meaningful verbal material was not
      related to blood pressure.

PMID- 1017438
TI  - Biogenic amines in the Caenorhabditis briggsae.
AB  - Dopamine, epinephrine, norepinephrine and serotonin were demonstrated from
      homogenates of Caenrohabditis briggsae by two-dimensional thin layer
      chromotography and the identification confirmed by gas liquid chromtography. In
      Vitro studies with 14C precursors of these biogenic amines demonstrate the
      ability of C. briggsae to synthesize each compound. The results provide required
      preliminary data for studying the neurophysiology of aging utilizing the nematode
      as a model.

PMID- 1017439
TI  - Age differences in learning and memory on a digit-symbol substitution task.
AB  - Fifteen young (18 to 28 years) and fifteen old (65 to 75 years) persons were
      given ten 30-second trials on a modified Digit-Symbol task. Both immediate and
      delayed (24-hour) recall and recognition measures were used to determine how well
      they remembered the digit-symbol pairs. Both age groups showed similar,
      significantly improvement over the 10 trials, although the performance level of
      the young group was higher throughout. The young group showed significantly
      higher recall and recognition (both immediate and delayed) for the digit-symbol
      pairs and were more likely to report the use of mnemonic techniques in learning
      the pairs.

PMID- 1017440
TI  - Disparate time spans in sequential studies of aging.
AB  - In several published studies of intelligence and adult age, a sequential design
      was used in which birth cohort and time of measurement were the independent
      variables in an ANOVA. The time span of these two variables were quite disparate;
      the cohort variable covered about 50 years whereas the time-of-measurement
      variable covered 7 or 14 years. It was demonstrated here that when time spans are
      disparate, even when all differences are attributable entirely to age changes,
      the F values typically will be larger for the cohort variable and errors in
      interpretations became likely. When cohort differences are statistically
      significant and time-of-measurement differences are not, the conclusion that age
      differences are "generational" and not due to age changes within individuals may
      be wrong.

PMID- 1017441
TI  - Health status as a variable in aging research.
AB  - Findings from several studies bearing on the association between disease and age
      associated behavior changes were briefly reviewed in order to stress the need for
      health assessment in gerontological psychology research. Despite the evidence
      favoring the need for health assessment such procedures have generally not been
      undertaken. Implications for experimental aging research were discussed.

PMID- 1017442
TI  - Partitioning chi-square the analysis of contingency tables with repeated
      measurements.
AB  - Categorical variables are commonly used in gerontological research. Although
      analysis of such variables presents no problem as long as the observations are
      independent, problems do arise when they are found in a design with repeated
      measurements. In this paper, two procedures from the statistics literature are
      combined to provide an analysis for data from a mixture of between and within
      categorical variables. First, a response pattern is used to form a contingency
      table with observations which are completely independent. Next, the Pearson chi
      square statistic from the table is partitioned to provide tests analogous to
      simple effects in analysis of variance.

PMID- 1017443
TI  - "Attitudes" toward the elderly: a comparison of measures.
AB  - College students were presented five questionnaires traditionally used to assess
      attitudes toward old people. The intercorrelations among the measures were low,
      accounting for no more than 24% of the variance between any two measures. The
      results suggest that the measures are not equivalent; it was argued that the
      practice of utilizing a single instrument to measure attitudes toward the elderly
      may contribute to inconsistencies reported in the literature.

PMID- 1017444
TI  - Age differences in cognition in healthy educated men: a factor analysis of
      experimental measures.
AB  - Performance measures for a wide variety of cognitive laboratory tasks were factor
      analyzed, and the factors were identifiable as aspects of cognitive processing.
      The sample consisted of 96 healthy, educated men whose ages ranged from 20 to 80
      yr. The factors were identified as speed of information processing, secondary
      memory, attention, and primary processing efficiency. Factor scores for each
      factor were correlated with age; r = -0.35, -0.30, -0.40, and -0.15 respectively,
      with better performance associated with lower age. The sample was divided into
      subsamples of 32 young (20-39), 32 middle (40-59), and 32 old (60-80) subjects;
      and each subsample was factor-analyzed separately to determine whether the factor
      structure was similar for all age groups. Evidence for factor-structure
      invariance with adult age was found in that all four factors in the primary
      analysis were identifiable in each of the age subsamples. The findings are
      consistent with a model of continual cognitive decline with age in healthy,
      educated adult males.

PMID- 1017445
TI  - Age and tachistoscopic perception.
AB  - A perception experiment involving tachistoscopic exposures of 10 alphabetic
      characters was conducted in order to answer the following questions. Do young and
      old adult subjects exhibit performance differences in tachistoscopic perception
      which involves the earliest stages of information processing; and, if so, what is
      the nature of these differences? The answer to the first part of the question was
      a clear and definite yes. Old adult subjects were found to perform at a
      significantly lower level than younger adult subjects in nearly all measures of
      perceptual performance. With respect to the second part of the question, both
      strategy and capacity differences were found to be responsible for the poorer
      performance of the older subjects. The older subjects used a suboptimal
      performance strategy more frequently, and were apparently slower at processing
      visual information than younger subjects.

PMID- 1017446
TI  - Aging and in vivo norepinephrine-uptake in mammalian brain.
AB  - In order to examine the cellular effect of aging in the central nervous system,
      the regional distribution and the dynamic aspects of catecholamine metabolism in
      the brain were investigated. Results indicated that the endogenous norepinephrine
      (NE) content is lower in hypothalamus and brain stem of older rats (25 mo. n = 6)
      than younger rats (12 mo. n = 6). We have also observed in these animals that the
      age pigments were apparently absent in the brain tissue of young rats but become
      a very distinct feature for the old rats and that the catecholamine strong
      vesicles appear to be less dense in the nerve terminals of old as compared with
      the young ones. 3H-NE was administered intracerebrally to mice of different age
      groups (4, 8, 12, 21 and 24 months) and the NE-uptake activity was examined by
      measuring the radioactive NE inside the isolated synaptosomes 5 min after 3H-NE
      injection. The result indicated that the young group (4 mo) has highest uptake
      activity. The uptake activity decrease with the older mice and reached the lowest
      in the age group of 21-24 mo. The decrease in NE-uptake activity may be related
      to the deterioration of synaptosomal membranes.

PMID- 1017447
TI  - Growth, development and activity in rat offspring following maternal drug
      exposure.
AB  - Seventy-nine Sprague-Dawley derived primimparous rats were injected
      subcutaneously throughout pregnancy and the nursing period with either (1) 30
      mg/kg of pure nicotine, (2) 5.0 mg/kg methamphetamine HCL, (3) saline vehicle,
      or, (4) non-injected. Vital and developmental measures were taken on the
      offspring throughout the nursing period and for one additional week.
      Metamphetamine-injected females had a shorter, and nicotine-injected females a
      longer gestational period, and both gained less weight over the 21-day period
      than the control groups. The pups of methamphetamine and nicotine dams were
      significantly underweight at birth and the 28 day postnatal period and exhibited
      developmental delay. Male offspring were divided into behavioral, aging, and
      autopsy on Day 28. Male offspring of methamphetamine-injected dams remained
      significantly lighter in weight for the first 15 months of life (aging groups).
      Their counterparts in the behavioral groups and the offspring of non-injected
      dams exhibited significantly greater activity for eight of the first twelve
      monthly assessments which began at 90 days of age. Additional vital, performance,
      and sensory measures will continue throughout the lifespan of the animals.

PMID- 1017448
TI  - Age, sex and genotype effects on stimulus exploration and locomotor activity in
      young mice.
AB  - Age and sex effects on stimulus exploration and locomotor activity were
      investigated in three genetic stocks of mice. Three measures of exploratory
      behavior and one measure of locomotor activity were recorded in an arena testing
      situation. The results showed that measures requiring locomotor activity are more
      affected by differences in age and sex than measures of stimulus exploration. The
      results are discussed in terms of the previously established genetic models of
      stimulus exploration and activity.

PMID- 1017449
TI  - Matching, the null hypothesis and the aging variable: would the real age effect
      please stand up.
AB  - The concepts of hypothesis testing and maching are discussed in terms of their
      relationship to the findings of no age differences and sample bias, respectively.
      Suggestions are also offered concerned statistical substitutes for more rigid
      experimental controls.

PMID- 1017450
TI  - Age-related increase of cuticle permeability in the nematode Caenorhabditis
      briggsae.
AB  - The external cuticular surface of nematodes, which resembles cellular membranes
      in certain ways, appears to deteriorate with age. For example, when the
      permeabilities to radioactive water of young and old nematodes were compared, and
      the data were corrected for the different surface: volume ratios, the older
      nematodes were significantly more permeable. In both living and dead nematodes,
      the same rates of water exchange were observed, indicating that the major route
      of exchange was probably by passive diffusion through the cuticle rather than by
      active processes such as swallowing or excreting water.

PMID- 1017451
TI  - The relationship of scoring treatment and age in perceptual-integrative
      performance.
AB  - The present study was designed to reexamine the hypothesis that timed perceptual
      integrative performance tests are negatively biased measures of the abilities of
      the elderly. Unlike an earlier study by Doppelt and Wallace (1955) which did not
      support this hypothesis, the current study consisted of a college-age group in
      addition to the elderly group, and also included an additional scoring treatment.
      Each subject was tested with the WAIS Block Design and Object Assembly. Tests
      were scored in three ways: (1) Standard scoring (WAIS Manual); (2) "regular"
      scoring (timed, omitting bonus points); (3) "Irregular" scoring (untimed,
      omitting bonus points). For both tests, Age, Scoring, and the Age by Scoring
      ineraction were significant. Post hoc analyses for significant effects suggest
      that the elderly are helped most by additional solution time, whereas younger
      adults derive greater benefits from the bonus points for quick performance. The
      results also suggest that subjects must be of sufficiently high ability to
      effectively use increased or unlimited solution time.

PMID- 1017452
TI  - The effect of age on the speed of sentence formation and incidental learning.
AB  - To test the hypothesis that older persons tend not to use verbal mediators in
      paired-associate learning because it takes them too long to form an appropriate
      mediator, the time needed by young and old subjects to generate sentences
      incorporating given pairs of nouns was measured. Older subjects formed sentences
      just as rapidly as did the young. Despite their equivalent speed in creating
      these verbal associations when tested later for the occurrence of incidental
      learning of the noun pairs, the older subjects showed much poorer recall than did
      the younger subjects. This age difference in learning did not appear to be a
      function of any major dissimilarities in the generated sentences themselves,
      i.e., in the grammatical constructions used, or in the imageability of the
      relationships expressed by the sentences. The rated imagery value of the stimulus
      nouns was found to affect both the speed of sentence formation and the accuracy
      of incidental learning; in both younger and older subjects, formation time was
      less, and recall was better for the high imagery noun pairs.

PMID- 1017453
TI  - Differences in the sequential integration of form as a function of age and
      interstimulus interval.
AB  - The sequential integration of visual stimuli was studied in 12 young (18-28
      years) and 12 old (51-62 years) men and women. Stimuli were constructed as
      corresponding word halves and inter-stimulus intervals (ISI's) of varied duration
      (0-150 msec.) were introduced between the presentation of the two halves. Correct
      word identification was found to be an inverse function of ISI for both young and
      old subjects. The number of stimuli correctly identified was significantly lower
      for the older subjects at all levels of ISI. None of the interactions of age,
      sex, and ISI was significant. The data appear to question the "stimulus
      persistence" model as applied to age differences in the temporal organization of
      form.

PMID- 1017454
TI  - Speed and age: multiple rates of age decline.
AB  - There is frequent reference in the literature on aging and performance to the
      "slowing with age phenomenon". If there truly is one "slowing with age"
      phenomenon, then all activities requiring speeded performance should decline with
      age at approximately the same rate. This report compares relative rates of age
      decline in several speeded physical activities ranging from simple reaction time
      to long distance running events. The activities differ in the rate of slowing
      with those requiring a greater muscular involvement or more stamina exhibiting
      the steepest declines. It is concluded that when one refers to slowing with age
      it is necessary to be quite specific about the activity to which one is referring
      because different activities decline at different rates.

PMID- 1017455
TI  - Attrition in a longitudinal study of an aged population.
AB  - This report focuses upon attrition in longitudinal studies of older persons using
      a Florida survey as an illustration. In 1959 interviews were completed with a
      probability sample (N = 2544) of older noninstutionalized residents (age 65+) of
      a retirement community. Data were collected on health status, health practices,
      social factors, and activities. Nine years later a follow-up study of the same
      sample was undertaken. In this report 1959 data for 2497 of these persons are
      analyzed by results of the 1968 effort (reinterviewed, lost to follow-up, or
      deceased). About one third of this highly migratory sample could not be located
      in 1968; death certificates were located for another one third; and the remaining
      one third was reinterviewed. Social characteristics, housing arrangements,
      activities, and chronic conditions of the three subpopulations are compared.
      Persons reinterviewed were found to differ from dropouts in age, sex, type of
      dwelling unit, activity patterns, and prevalence of chronic conditions. No
      significant differences were found in educational level, household composition,
      usual occupation, and retirement status (when controlled for sex).

PMID- 1017456
TI  - Thresholds of food odors in the elderly.
AB  - Thresholds for nine food odors were found for two groups of subjects, young and
      elderly. Dravniek's dynamic triangle olfactometer, which employs the forced
      choice, triangle principle and controls for guessing was used. Elderly subjects
      were found to have a considerably reduced sensitivity to these odors compared
      with young subjects.

PMID- 1017457
TI  - Relationship between central and autonomic nervous system activity: correlates of
      psychomotor performance in elderly men.
AB  - The relationship between heart rate deceleration (HRD) and the contingent
      negative variation (CNV) was evaluated in 12 healthy, elderly men during
      performance of a signaled reaction time task. While amplitude of the CNV and HRD
      did parallel RT, CNV alone was found to be predictive of individual differences
      in speed of response indicating that phasic concordance of these physiological
      responses is probably not an important factor in age changes in RT. The results
      indicate the probable importance of central physiological indices such as the CNV
      over peripheral events such as HRD in the evaluation of RT performance in elderly
      individuals.

PMID- 1017458
TI  - Ethanol preference in C57BL/6 and BALB/c mice at three ages and eight ethanol
      concentrations.
AB  - Eight ethanol concentrations (4%, 6%, 8%, 10%, 12%, 14%, 16%, 18%) were used. A
      reduction in ethanol preference with increasing age was seen in the C57BL/6 mice,
      but not in the BALB/c animals. For C57BL/6 mice the largest difference in ethanol
      preference occurred between the 10% and 18% ethanol solutions. It was found that
      the ethanol preference of the 14-16 mo. C57BL/6 mice was similar to the 7-9 mo.
      old C57BL/6 mice at the first 5 concentrations. For the remaining concentrations
      the 14-16 mo. mice more closely resembled the 22-24 mo. mice in ethanol
      preference. The results of this study suggested that increased age does not
      simply result in a reduction in ethanol preference, but is a function of the
      genotype and concentration of the ethanol solution.

PMID- 1017459
TI  - The relationship of task reinforcement to personal loss themes revealed in
      earliest memories of elderly subjects.
AB  - Institutionalization of the aged has been viewed as an environmental stressor,
      producing covert negative affect which is manifest as personal loss themes in the
      individual's earliest memories. It was hypothesized that reinforcement given for
      a cognitive task would produce a positive emotional response in the individual
      and result in decreased personal loss feelings. Subjects were 64 elderly persons
      (aged 65-88); half of each sex, half nursing home and half community residents,
      half receiving reinforcement and half receiving none. Subjects' earliest memories
      were scored for personal loss themes. Significant findings were that among
      subjects who were reinforced, those in the community had higher loss scores than
      those in the nursing home; there was no difference in loss scores between
      community and nursing residents who had not been reinforced. Among community
      subjects, those who were reinforced had significantly higher loss scores than
      those who were not; the opposite tendency was observed in nursing home subjects.

PMID- 1017460
TI  - Misuse of analysis of covariance in aging research revisited.
AB  - Storandt and Hudson's treatment of the issue of which general linear model
      technique is preferable to use when age effects are confounded is misleading.
      Contrary to their position that hierarchical ANOVA or step-wise multiple
      regression is superior to ANCOVA, it is demonstrated, using hypothetical data,
      that identical amounts of variance can be explained by ANCOVA relative to
      hierarchical ANOVA and multiple regression. Multiple regression is recommended as
      the most appropriate technique for a variety of pragmatic reasons concerning
      calculation of significance tests, the distinction between gross and net effects,
      and the choice of the metric used in measurement.

PMID- 1017461
TI  - Monetary incentive, age, and cognition.
AB  - Results from studies of cohort differences suggest that older and younger
      volunteers may differ in aspects other than age. In this study subjects, who had
      or had not been promised $10.00 payment for their participation, were compared on
      certain personality and intelligence factors. No differences between incentive
      conditions were observed for 2466 potential subjects on willingness to
      participate, nor for 591 subjects eventually tested on their scores on the
      Primary Mental Abilities Test, the Test of Behavioral Rigidity and Cattell's 16
      PF. However, differences by incentive condition were observed on the
      intercorrelation matrices for women on Form B of the 16 PF. Results of these
      analyses suggest that, with few exceptions, supplying a monetary incentive to
      induce subjects to participate in a study does not significantly alter the
      characteristics of a volunteer sample with regard to age or sex.

PMID- 1017462
TI  - Aging effects on hypothalamic dopamine and norepinephrine content in the male
      rat.
AB  - Hypothalamic content of dopamine and norepinephrine was measured in young (4 mo)
      and aged (24-26 mo) male rats by aluminum oxide adsorption and microfluorescence.
      Hypothalamic content of both dopamine and norepinephrine was significantly less
      in aged than in the young groups. Average dopamine content of the young and aged
      groups was 32.5 +/- 9.3 and 15.6 +/- 2.5 ng/hypothalamus, respectively.
      Norepinephrine content averaged 47.6 +/- 10.7 and 22.8 +/- 1.8 ng/hypothalamus in
      the young and aged groups. These data suggested that alterations in hypothalamic
      catecholamine function contribute to changes in endocrine control mechanisms
      during aging.

PMID- 1017463
TI  - Trithiozine (ISF 2001): gastric antisecretory effects and treatment of peptic
      ulcer.

PMID- 1017464
TI  - Metabolism of carbamazepine-10,11-epoxide in rats.

PMID- 1017465
TI  - Radiopaque contrast media. XL- Isolation and identification of the metabolites of
      iopronic acid in the urine and bile of the dog.

PMID- 1017466
TI  - Radiopaque contrast media. XLI-Isolation and identification of the metabolites of
      iopronic acid in the rat.

PMID- 1017467
TI  - Radiopaque contrast media. XLII-Metabolism of iopronic acid in human.

PMID- 1017468
TI  - [Cerebrovascular disorders : facial thermography as a means to evaluate the
      therapeutic effectiveness of nicergoline].

PMID- 1017469
TI  - [Preliminary electroencephalographic study on the effects of propranolol in man].

PMID- 1017470
TI  - Experimental EEG study on central effects of propranolol.

PMID- 1017471
TI  - [Bioavailability of raubasine in various pharmaceutical forms in the dog].

PMID- 1017472
TI  - The effect of compression force on the characteristics of coated acetylsalicyclic
      acid tablets.

PMID- 1017473
TI  - [Instrumental analysis in pharmaceutical research].

PMID- 1017474
TI  - Dissolution and enzymatic hydrolysis of chloramphenicol palmitic and stearic
      esters.

PMID- 1017475
TI  - The functional capacity of the isolated perfused rat liver in relation to the
      colloidal-osmotic composition of the perfusion medium.

PMID- 1017476
TI  - [Evaluation of the precision and accuracy of analytical methods for medical
      specialities using the technic of reconstructed pharmaceutical preparations].

PMID- 1017477
TI  - [Rapid determination of caffeine in coffee and decaffeineted coffee using high
      pressure liquid chromatography].

PMID- 1017478
TI  - O- and N-alkylation with "Meerwein's reagent": the unusual behaviour of two
      lactams.
AB  - Usually tertiary oxonium salts are excellent O-alkylating agents of lactams; in
      some cases indiscriminate O- and N-alkylations have been described. In this paper
      the particular behaviour towards Meerwein's reagent of two isomers with a
      lactamic structure is pointed out: in one case the usual O-alkylation occurs, in
      the other N-alkylation is the only reaction that takes place.

PMID- 1017479
TI  - [Effects of various natural prostaglandins on human gastrointestinal motility in
      vitro].
AB  - The effects of three natural prostaglandins, E1, E2 and F2alpha, on the human
      gastrointestinal tract were investigated by means of an in vitro technique.
      Prostaglandin F2alpha showed a stimulatory effect on all the segments examined
      and its activity was comparable to that of acetylcholine (threshold doses 0.5-2
      mug). Prostaglandin E1 relaxed the circular muscles of the stomach (minimum
      active dose was 1 mug/ml) but contracted the longitudinal ones and taenia coli.
      Prostaglandin E2 showed an interesting inhibition of the stimulant effect of
      acetylchooline on circular muscles of the stomach (1 mug/ml) and a weak
      spasmogenic activity on the other tracts. The mechanism of action of
      prostaglandins has not been completely elucidated; it seems plausible to suggest
      a direct effect of the drugs on the smooth muscle, however the release of an
      unknown mediator cannot be excluded.

PMID- 1017480
TI  - [Homoanalogs of aldofuranosylnucleosides. XI. 3,6-Anhydro-1-deoxy-1-(5
      halogenouracil-1-yl)-D-mannitol].
AB  - 3,6-Anhydro-1-deoxy-1-(5-bromouracil-1-yl)-D-mannitol (II) and 3,6-anhydro-1
      deoxy-1-(5-iodouracil-1-yl)-D-mannitol (III) were prepared by direct halogenation
      of the corresponding bis-homonucleosides; the 5-fluoro isomer (V) was prepared by
      N-alkylation of 5-fluorouracil by 2-o-acetyl-3,6-anhydro-4,5-o-isopropylidene-1-o
      p-tolysulfonyl-D-mannitol in dimethylsulfoxide in the presence of potassium
      carbonate followed by hydrolysis of the protective groups in an acid medium. The
      ultraviolet spectroscopy, mass spectrometry and nuclear magnetic resonance
      studies of these compounds are described and the results of pharmacological tests
      on L 1210 leukemic cells are given.

PMID- 1017481
TI  - [Research on heterocyclic compounds. V. Imidazo/2,1-b/thiazole-6-ascetic acids
      and imidazo/2,1-b/benzothiazole-2-acetic acids].
AB  - We have prepared a group of ethyl imidazo [2,1-b]thiazole-6- and imidazo[2,1
      b]benzothiazole-2-acetates, starting from some substituted 2-aminothiazoles and 2
      aminobenzothiazoles, by reaction with ethyl 4-bromoacetoacetate. From these
      esters we have obtained the corresponding acetic acids, and we have tested their
      anti-inflammatory activity.

PMID- 1017482
TI  - Structure-activity relationship for antitumor thiosemicarbazones.
AB  - The in vitro antitumore activity of a series of thiosemicarbazones was studied by
      means of the Free-Wilson method. Both lipophilic and electronic effects are shown
      to play an important role.

PMID- 1017483
TI  - Antimycotic activity in vitro and in vivo of a new hydrosoluble polyene
      antibiotic.
AB  - The in vitro and in vivo activity of a new water soluble polyene antibiotic,
      anmed SPA-S-222, has been studied on numerous Candida and Cryptococcus species.
      The in vitro tests were carried out in comparison with nystatin and amphotericin
      B whose antimycotic properties are already well known. The inhibition of
      "germination" of various strains of Candida albicans was also investigated. The
      results show that SPA-S-222 has greater antimycotic activity than nystatin or
      amphotericin B. Tests on the protection afforded by SPA-S-222 in Swiss albino
      mice infected with C, albicans were satisfactory as regards both the total
      protective dose and the partial protective dose (P.D. 50%).

PMID- 1017484
TI  - Derivatives of 2H,3H-benzimidazo(1,2-b)oxazole.
AB  - The Authors report the synthesis and chemical properties of a number of
      derivatives of 2H,3H-benzimidazo(1,2-b)oxazole. These substances were prepared in
      order to investigate their pharmacological activity.

PMID- 1017485
TI  - [Relationship between chemical structure and sweet taste. XIII. Derivatives of L
      acylamidosuccinanilic acids].
AB  - Several derivatives of L-acylamidosuccinanilic acids have been prepared inorder
      to study the relationship between the chemical structure and the sweetening
      activity by modifying the amino or the acylamido portions of the molecule. Some
      synthesized compounds possess a pronounced sweet taste, the L-4'-nitro-(2,2,2
      trichloroacetamido)succinanilic acid is the most outstanding compound, being
      approximately 3000-4500 times as sweet as sucrose.

PMID- 1017486
TI  - [Retrospective analysis of drug projection using correlative technics].
AB  - The problem of choosing substituents to allow correct correlative analysis
      according to the "Hausch Approach" is discussed. The problem of colinearity among
      parameters is considered in a case study on 296 anilides which inhibit the Hill
      reaction. The difficulty in of determining whether, pi or MR is the important
      variable in changes in activity is shown. "Cluster analysis" is discussed and
      proposed as a rational method for the selection of substituents to be introduced
      into biologically active structure in order to explore the scope of each defined
      physico-chemical parameter. An example of the use of this method conerning auxin
      activity of 1- and 2-benzotriazole derivatives is given.

PMID- 1017487
TI  - Biological activities of a new specific stimulant of histamine H2 receptors.
AB  - Compound N-methyl-2-(5-methyl-4-imidazolyl)ethylamine (5-methyl-N
      methylhistamine) was submitted to a thorough pharmacological examination and was
      found to be a potent stimulant of H2 receptors, devoid of any appreciable effect
      on H1 receptors. Because of its high degree of specificity it therefore seems to
      represent an interesting drug to be used in clinical gastric secretory tests and
      an useful tool for the study of histamine H2 receptors.

PMID- 1017488
TI  - [Electrical reactions of the cerebellar cortex during stimulation of different
      groups of thalamic nuclei].

PMID- 1017489
TI  - [Effect of bilateral destruction of the head of the caudate nucleus on the
      carbohydrate function of the liver].

PMID- 1017490
TI  - [Change in bile formation under the influence of serotonin].

PMID- 1017491
TI  - [Effect of insulin on oxidative phosphorylation and concentration of sulfhydryl
      groups in the liver and spleen mitochondria of rats following hydrocortisone
      administration].

PMID- 1017492
TI  - [Catecholamine concentration in different parts of the heart in acute myocardial
      dystrophy].

PMID- 1017493
TI  - [Rat adaptation to contrasting temperatures].

PMID- 1017494
TI  - [Regulation of acid-base balance in the blood of fishes during their adaptation
      to changes in water temperature].

PMID- 1017495
TI  - [Effect of stimulation and destruction of the cortico-medial region of the
      amygdaloid nuclei on the testes of white rats with intact pituitaries and
      following hypophysectomy].

PMID- 1017496
TI  - [Effect of estradiol and progesterone on the thyroid gland and its sensitivity to
      thyroid hormone in rats of different sex].

PMID- 1017497
TI  - [Changes in the testes of sexually mature rats under the influence of the
      combined action of hypoxia, hypercapnia and cooling].

PMID- 1017498
TI  - [EEG studies of neurophysiologic features of paroxysmal states in pathology of
      the human limbic system].

PMID- 1017499
TI  - [Resuscitation following protracted clinical death from asphyxia by using the
      S.S. Briukhonenko method of artificial circulation].

PMID- 1017500
TI  - [Effect of antimyocytotoxic serum on the work capacity of animals of different
      ages].

PMID- 1017501
TI  - [Several indices of steroid homeostasis and reactivity of the adrenal cortex in
      patients with cancer of the uterine cervix before and after radiotherapy].

PMID- 1017502
TI  - [Influence of experimental conditions on several indices of acid-base and
      electrolyte homeostasis].

PMID- 1017503
TI  - [Effect of seawater in the concentration of DNA and RNA in the organs of rats].

PMID- 1017504
TI  - [Concentrating function of the frog gall bladder at different environmental
      temperatures].

PMID- 1017505
TI  - [Absorptive function of the pericardium in the dynamics of the course of
      experimental pleurisy].

PMID- 1017506
TI  - [Influence of frequency of splanchnic nerve stimulation on development of
      habituation in the cat cerebral cortex].
AB  - Changes of amplitude of evoked potentials in the areas SI and SII of the cortex
      on repeated stimulation of the splanchnic nerve were studied in anesthetized and
      immobilized cats. The rate of decrement amplitude responses is increased with
      increasing of the frequency of stimulation from 0.5 to 5 stimuli per 1 sec. in
      the focus of maximal activity and in peripheral areas SI and SII. The decrement
      responses are more obvious in the peripheral sites of these areas. The data
      obtained seem to indicate a development of habituation in the cortex.

PMID- 1017507
TI  - [Role of the medial region of the hypothalamus in regulating the activity of the
      respiratory neurons of the medulla oblongata].
AB  - The influence of high frequency stimulation of postero- and anteromedial
      hypothalamic regions on the activity of single neurons of the bulbar respiratory
      center was studied in anesthetized cats with normal respiration. No strictly
      localized facilitatory or inhibitory points were found in these regions.
      Excitatory as well as inhibitory descending pathways were activated by the
      hypothalamic stimulation. The effect was mainly facilitating. The excitatory and
      inhibitory influences of the medial hypothalamus modulated spike activity of both
      inspiratory and expiratory neurons of the bulbar respiratory center. Some
      functional aspects of the mechanism for hypothalamic regulation of the activity
      of bulbar respiratory neurons are discussed.

PMID- 1017508
TI  - [Thresholds of dorsal hippocampus stimulation for development of epileptiform
      discharges at different stages of the sleep--wakefulness cycle].

PMID- 1017509
TI  - [Features of individual sympathetic preganglionic neurons and their axons in the
      superior thoracic portion of the spinal cord].
AB  - The existence of B- and C-preganglionic fibers in T3 spinal cord segment was
      shown with the aid of recording the antidromic waves in the ventral root
      filaments elicited by corresponding white ramus stimulation. Conduction velocity,
      excitability, and refractory period of these fibers were obtained. Antidromic
      discharges of sympathetic preganglionic neurons with high-speed B-axons were
      found in ventral horn. Sympathetic preganglionic neurons of the lateral horn have
      B-axons with slower conduction velocity, and those situated in lateral part of
      the intermediate zone have C-axons.

PMID- 1017510
TI  - [Phasic character of the process of color sensitivity in the visual analyzer].
AB  - In subjects with normal three-chromatic vision, during long-term uninterrupted
      adaptation (6--8 min) to spectral stimuli of different spectral areas
      (lambda=650+585 nm; lambda=535+585 nm), it was found that the state of color
      sensitivity undergoes changes in the form of alternating active (correct) and
      passive (wrong) phases of color discrimination. First, the phase of active color
      discrimination prevails, then both phases become sort of balanced, and in the end
      of the adaptation the phase of passive color discrimination increases
      considerably. The time of duration of these phases depends on the wave--length of
      the adapting stimulus.

PMID- 1017511
TI  - [Interaction of muscle fibers in preserving indefatiguability].
AB  - Dynamics of isometric tension, EMG, and character of AP generation were studied
      in separate muscle fibers in albino rats during prolonged indirect stimulation
      (40 HZ) of m. gastrocnemius and m. soleus. M. soleus was capable to maintain 50-
      60% of maximal tension during 2.5 hrs, whereas m. gastrocnemius maintained only
      15--20% of the maximal tension for about 15 min after the onset of stimulation.
      According to character of AP generation, fibers of the muscles were divided into
      three major types: "silent", sporadically functioning, and constantly
      functioning. Mechanisms of these features of the muscle function are discussed.

PMID- 1017512
TI  - [Effect of intravenous infusions of thrombin and heterogenous blood on lymph
      coagulability].
AB  - In dogs, i.v. administration of thrombin leads to hypocoagulation, consumption of
      fibrinogen, increasing fibrinolysis, and to a slight raise of antithrombin. This
      has no connection with appearance of natural anticoagulants and fibrinolytic
      agents in the lymph stream. After the heterotransfusion shock, apart from
      hypocoagulation and hyperfibrinolysis in the blood, the incoagulability of lymph
      developes due to a sharp increase of free heparin in it. The hypocoagulation
      after the heterotransfusion shock seems to depend on appearance of anticoagulants
      in the tissue fluid and lymph. Common and different features of thrombin and
      heterogenic blood effects on the mechanism of hypocoagulation and
      hyperfibrinolysis, are discussed.

PMID- 1017513
TI  - [Thermoregulation in rats during combined adaptation to heat and cold].

PMID- 1017514
TI  - [Multi-channel microelectrodes for microiontophoretic feeding of substances to
      neurons].

PMID- 1017515
TI  - [Sodium and calcium ions and frequency-dependent contractile phenomena in fish
      myocardium].

PMID- 1017516
TI  - [Device for determining the concentration of osmotically active substances in
      biological fluids].

PMID- 1017517
TI  - Monitoring emergency nutrition programmes in India.

PMID- 1017518
TI  - Nutrition education at the village level.

PMID- 1017519
TI  - Benin: nutritional considerations on trace elements in the diet.
AB  - The increasing use of the atomic absorption technique makes it possible to study
      man's trace-element requirements with a very accurate methodology. Some of these
      elements are present in the daily diet in minute quantities of micrograms which
      are, however, indispensable for the proper functioning of the body. But apart
      from such trace quantities present in conditions which are not affected by
      abnormal environmental concentration, there may be situations in which trace
      element levels in foods and diets reach very high values. If very high, the
      levels may expose a population to the risk of toxicity; on the other hand, they
      may lead to wrong interpretations of trace-element requirements because they may
      lead the nutritionist to regard some high values as normal levels and therefore
      appropriate for meeting man's requirements. Inversely, they may also induce the
      nutritionist to regard lower values as unsatisfactory. Therefore, since these
      environmental factors, which are not always identifiable, can induce erroneous
      judgements due to overestimation of the requirements, it would seem appropriate,
      if figures on the total supplies of the diet are to be used, to refer to the
      tabled values of the individual foods of the diet, rather than to analyses of the
      whole diet ready for consumption. In fact, an abnormally high or low value of a
      trace element of any single food of a food composition table would have little
      influence on the calculation of the total supply of the diet, whereas the use of
      values obtained from meals which have been exposed to contamination during
      technological processes(e.g., through the cooking water of foods or cooking
      utensils) may result in overestimation. However, the analysis of global diets
      seems to be the method of choice in toxicological research, because in this type
      of investigations the basic elements of an evaluation often derive indeed from
      abnormal conditions identified at consumer level. Regarding the importance of
      copper and iron in haematopoiesis, the following hypotheses can be put forward:
      (a) In the haematopoietic phenomena occurring in intrauterine life, copper seems
      to play a role equal to that of iron, and perhaps even more important. (b) This
      role does not seem to be an autonomous one, but is mediated by availability of
      serum globulin to the child. In other words, this hypothesis relates the problem
      more generally to the protein nutrition of mother and foetus...

PMID- 1017520
TI  - [Report on 3 cases of toxic phytophotodermatitis due to Heracleum mantegazzianum
      (giant cow parsnip)].

PMID- 1017521
TI  - [Photochemotherapy of psoriasis using 8-methoxypsoralen and UVA. II. Binding of
      the photosensitizator to protein].

PMID- 1017522
TI  - [Spectrophotometric studies on the dectection of photosensitizing agents].

PMID- 1017523
TI  - [Significance of the paramecium-test for the detection of photosenziting agents].

PMID- 1017524
TI  - [Immunologic behavior of progressive scleroderma].

PMID- 1017525
TI  - [Specific desensitization in patients with chronic urticaria due to yeasts and
      intestinal colonization of yeasts].

PMID- 1017526
TI  - Role of keratinases in dermatophytosis. IV. Reactivities of sera from guinea pigs
      with heat-inactivated keratinase II.
AB  - Complement-fixing antibodies to the heat-inactivated keratinase II of
      Trichophyton mentagrophytes var. granulosum were detectable in sera from
      approximately 40% of the Hartley strain guinea pigs previously infected with this
      dermatophyte. However, no precipitating antibodies to the heat-inactivated
      keratinase II were detectable in these sera. Guinea pigs immunized with the heat
      inactivated keratinase II had both complement-fixing and precipitating antibodies
      to the keratinase II. Circulating antibodies in sera from both the infected and
      the immunized guinea pigs also reacted with the active keratinase II but did not
      inhibit its proteolytic activity.

PMID- 1017527
TI  - [Corneal lesions in ichthyosis].
AB  - Corneal lesions in ichthyosis, here combined with alopecia, are rarely described
      in the literature. The present observation relates to two sisters, whose
      grandparents were siblings. The mode of inheritance is autosomal recessive, as is
      usual in ichthyosis congenita but is also observed in ichthyosis vulgaris. The
      clinical picture and the histological findings correspond to ichthyosis vulgaris.

PMID- 1017528
TI  - Treatment of vitiligo with oral corticosteroids.
AB  - 17 patients with generalized vitiligo and 5 patients with localized vitiligo were
      treated with oral corticosteroids. Six patients with generalized vitiligo showed
      over 75% repigmentation in at least one of the patches. Two patients with
      generalized vitiligo and 1 patient with localized vitiligo showed a partial
      repigmentation of 25-75%, while 5 patients with generalized vitiligo and 1
      patient with localized vitiligo showed a minimal repigmentation of less than 25%.
      Four patients with generalized vitiligo and 3 patients with localized vitiligo
      failed to respond. Repigmentation became evident within 4 weeks in most cases,
      and in general was more markedly noted in exposed areas.

PMID- 1017529
TI  - Pyoderma gangrenosum with Koebner effect and Mondor's disease in the same
      patient.

PMID- 1017530
TI  - Lymphangioma circumscriptum of the tongue.
AB  - A case is reported of severe transient macroglossia after biopsy from the tongue
      in a 13-year-old boy who has had intermittent macroglossia since the age of 1
      year as a result of extensive lymphangioma circumscriptum of the tongue. The
      acute lesions appear to result from haemorrhage into the lymphatic spaces
      following rupture of blood vessels in connective tissue septa and possibly
      secondary infection.

PMID- 1017531
TI  - Generalized granuloma anulare in a 15-month-old infant.
AB  - A Japanese girl aged 15 months had an eruption of 3 months' duration on the face,
      trunk, and extremities except for the palms and soles. The lesions were
      infiltrated papules varying from 2 to 3 mm in diameter. Blood eosinophilia of 5%
      was demonstrated. Skin biopsy specimen revealed a necrobiotic palisading
      granuloma in the corium. All lesions began to subside after 1 weeks'
      administration of oral corticosteroid and completely involuted in 2 months. A
      possible etiologic role of insect bites was considered.

PMID- 1017532
TI  - Cell-mediated immunity in epidermodysplasia verruciformis.
AB  - Investigations were performed in 6 cases of epidermodysplasia verruciformis and 2
      healthy family members. Nonspecific cell-mediated immunity (CMI) was studied by
      measuring response to phytohemagglutinin (PHA) and concanavalin A (Con A),
      percentrages of E- and EAC-rosette-forming lymphocytes, bacterial skin tests, and
      allergic reactions to dinitrochloro-benzene (DNCB). Impairment of CMI was
      manifested by reduction in the percentage of E rosettes, and lowered response to
      PHA, and- to a lesser degree- to Con A. The immune response to DNCB sensitization
      was invariably negative. Impairment of CMI was greater in cases of long duration
      and with extensive lesions. The cases of similar duration and extent of lesions,
      which never showed tendency to tumor formation, were not different in CMI in
      comparison with cases with numerous tumors. Only in cases with very advanced
      tumors CMI was impaired parallel to the gravity of the patient's general
      condition.

PMID- 1017533
TI  - Onset of the vasoconstrictor effect of diflucortolone valerate, betamethasone
      valerate, and fluocinolone acetonide ointments applied for varying periods under
      occlusive dressings.
AB  - Evaluation of cutaneous vasoconstriction after applications of varying duration
      of topical corticoids on the flexor surfaces of the forearms of 20 patients with
      intact skin shows a significantly faster blanching effect with diflucortolone
      valerate ointment than with fluocinolone acetonide and betamethasone valerate
      ointments. Furthermore, the test shows that even for a highly active preparation,
      such as the diflucortolone valerate ointment, an application time of less than 3
      h only exceptionally leads to vasoconstriction in the healthy skin.

PMID- 1017534
TI  - Diffuse biphasic amyloidosis.

PMID- 1017535
TI  - Reproduction and human welfare: a challenge to research.

PMID- 1017536
TI  - The epidemiology of hyperlipoproteinemia in a Rumanian general population sample.
      Study of 7,085 cases.
AB  - Using a two stages screening method the prevalence in the general population of
      hyperlipoproteinemias (HLP), separated in the five types proposed by Fredrickson,
      Levy and Lees, and adopted by WHO has been studied. The study included 7,085
      subjects of both sexes, aged 25-65 years, representing 84,52 % of a population
      taken at random within a district of Bucarest. HLP was found in 1,013 cases, i.e.
      14,29 % of the investigated population. 48.37 % were men and 51.63 % women. The
      prevalence of HLP was lowest in the first decace of age studied (25-35 years) and
      highest in the last two decades (45-65 years). Overweight was more frequently
      encountered in these patients (64.46 %) than in the total population (32.3 %). Of
      the 1,013 cases with HLP, 42.35 % (6.05 % of the total population) were of type
      IV, 27.05 % (3.86 % of the total population) of type II-b, 22.80 % (3.26 % of the
      total population) of type II-a, 4.74 % (0.67 % of the total population) of the
      type III and 3.06 % (0.43 % of the total population) of the type V. 22.70 % of
      the HLP patients were considered primary familial HLP, 66.54 % primary non
      familial HLP and 10.76 % secondary HLP; IN 109 secondary HLP, the most frequently
      encountered disease was diabetes mellitus (42.20 %), followed by hypothyroidism
      (24.77 %), alcoholism (12.84 %), obstructive liver diseases (9.17 %),
      pancreatitis (5.50 %), nephrotic syndrome (2.75 %) and treatment with estrogens
      and steroids (2.75 %).

PMID- 1017537
TI  - [Diabetes and synovial chondromatosis (author's transl)].
AB  - In the series of the fourty cases of synovial chondromatosis observed at the the
      department of rheumatology of Marseille since 1960, seventeen patients were
      suffering from diabetes mellitus, all of them not-insulin-dependent. This raises
      the question of the nature of this association, not previously reported.

PMID- 1017538
TI  - Vitamin B 12 and folic acid serum levels in diabetics under various therapeutic
      regimens.
AB  - The aim of the present study was to reconsider the problem of the haematological
      consequences of biguanide treatment by evaluating serum vitamin B 12 and folic
      acid levels as well as classical haematological parameters in 30 diabetics
      treated by metformin. For purpose of comparison, similar evaluations were done in
      diabetics treated with insulin (27 patients) or sulfonylureas (13 patients).
      Results indicated that mean serum levels of vitamin B 12 were significantly lower
      in patients receiving metformin than in both other groups. In the metformin
      treated group, five patients had serum levels of vitamin B 12 below 270 pg/ml and
      five had borderline values. No difference was found in the mean serum folic acid
      levels between the three groups. Similarly, there were no differences in the red
      blood cell counts, volumes or haemoglogin concentrations nor in the mean values
      of serum iron and lacticodeshydrogenase levels between the three groups. Since
      the haematologic and neurologic complications of vitamin B 12 deficiency may only
      appear after the deficiency had existed for 10-15 years, the lack of
      haematological alteration may be explained by the fact that the vitamin B 12
      deficiency was not present for a sufficient period of time. We conclude that it
      may be wise to monitor the haematological values as well as vitamin B 12 levels
      at regular intervals in diabetic patients treated with metformin so that B 12
      hypovitaminosis and its complications can be prevented.

PMID- 1017539
TI  - Hypoglycaemia induced by adrenal gland neoplasia (Anderson's syndrome) : report
      of a case.
AB  - A patient with hypoglycaemia associated with an adrenal neoplasia (Anderson's
      syndrome) is reported. Endocrinological investigation showed increased secretion
      of cortisol and catecholamines as well as an increased urinary steroid excretion
      along with profound inhibition of both basal and stimulated insulin secretion.
      During IVGTT, Conard's coefficient was reduced. The hyperglycemic response to
      glucagon injection was blunted, suggesting that liver glycogen stores were
      decreased or unavailable.

PMID- 1017540
TI  - [Sex differences in the blood glucose fall induced by short fasts (author's
      transl)].
AB  - Overnight fasting venous plasma glucose concentration was lower in premenopausal
      women than in men. This difference increased during a low caloric and low
      carbohydrate diet and above all after a 48 h fasting period. Venous blood glucose
      variation during this period of fasting was the same in post-menopausal women as
      in men. These facts and the previous observation by our group of a fall in
      fasting and post absorptive venous blood glucose after intramuscular injection of
      oestradiol benzoate (10) indicate that sex variations in the blood glucose fall
      following a period of fasting are at least partly linked to the oestrogenic
      status of the premenopausal woman.

PMID- 1017541
TI  - [Artificial insemination by frozen donor sperm. Psychological, judicial, moral
      and religious aspects].

PMID- 1017542
TI  - Assessment of pregnancy testing for population programmes.

PMID- 1017543
TI  - Intrauterine progesterone-releasing contraceptive systems.

PMID- 1017544
TI  - [Advances in the biology of gametes. I. Problems in males].

PMID- 1017545
TI  - [Advances in the biology of gametes. II. Biology of female gametes].

PMID- 1017546
TI  - [Salmonella serotypes isolated from dead animals, products of animal origin and
      fodder].

PMID- 1017547
TI  - [Carrier state of Salmonella bacilli in epidemic foci in the lomza region].

PMID- 1017548
TI  - [Properties of Mycobacterium avium and atypical mycobacteria isolated from
      animals in Poland].

PMID- 1017549
TI  - [Agglutination reactions in the performance of reduction tests].

PMID- 1017550
TI  - [Evaluation of bactericidal activity of Sterinol, Hibitan, Roccal, Sagrotan and
      Kodan].

PMID- 1017551
TI  - [Determination of selenium content in the blood of milking cows from Lower
      Silesia].

PMID- 1017552
TI  - [Efficacy of treatment of mastitis in cows with Orbenin Dry Cow and indications
      for its use].

PMID- 1017553
TI  - [Effect of liver fluke treatment in cows and the yield of milk].

PMID- 1017554
TI  - [Prophylactic use of Trimerazine and Tylavit-Sulfa during early periods of pig
      fattening].

PMID- 1017555
TI  - [Pilobezoars as a cause of tympany in calves in the course of intensive
      fattening].

PMID- 1017556
TI  - [Absorption of Trimerazine and Biseptol in calves and piglets (preliminary
      report)].

PMID- 1017557
TI  - [Hydrops of the gallbladder in a calf].

PMID- 1017558
TI  - [Aplasia of the right kidney coexisting with an abnormal left kidney in a dog].

PMID- 1017559
TI  - [Vaccines against leptospirosis].

PMID- 1017560
TI  - [Etiology of pathological changes in the liver of fattened geese].

PMID- 1017561
TI  - [Aerosol immunization of pigs against erysipelas].

PMID- 1017562
TI  - [Effectiveness of fenbendazole (Panacur-Hoechst) and cambendazole (MSD) against
      roundworms in horses' alimentary tract].

PMID- 1017563
TI  - [Role of esophagostomiasis in the breeding of suckling piglets].

PMID- 1017564
TI  - [Effectiveness of Terenol-Hoechst and Zanil-ICI in the control of Paramphistomum
      sp. in cattle].

PMID- 1017565
TI  - [Effectiveness of various coccidiostatics in the control of Eimeria necatrix in
      poultry].

PMID- 1017566
TI  - [Treatment of hoof rotting in sheep].

PMID- 1017567
TI  - [Effect of subclinical invasion of Trichocephalus suis on body weight gain in
      pigs].

PMID- 1017568
TI  - [Semen quality in bulls during their growth in the 1st year of life].

PMID- 1017569
TI  - Peripheral progesterone levels in pregnant and non-pregnant heifers following use
      of HCG.

PMID- 1017570
TI  - [The phenomenon of conduction. Marginal comment on a lecture by J. Mackenzie].

PMID- 1017571
TI  - [Arthralgia and arthritis during a course of acute viral hepatitis. Incidence,
      prognostic significance and correlation with hepatitis B antigen (HBsAg)].

PMID- 1017572
TI  - [Changes in the serum levels of isoenzymatic fractions of lactate dehydrogenase
      during cytostatic therapy].

PMID- 1017573
TI  - [Health problems among the student population of the autonomous National
      University of Mexico. I. Introduction].

PMID- 1017574
TI  - [Most frequent diseases among the university population].

PMID- 1017575
TI  - [Health problems among the student population of the autonomous National
      University of Mexico. IV. Proposed solutions. Health education for the university
      student].

PMID- 1017576
TI  - [Health problems among the student population of the autonomous National
      University of Mexico. III. Comments and conclusions].

PMID- 1017577
TI  - [Endocrinology and genetics].

PMID- 1017578
TI  - [Brain stimulation, further therapeutic approach of epilepsy].

PMID- 1017579
TI  - Accuracy of diagnosis of cancer among autopsy cases: JNIH--ABCC population for
      Hiroshima and Nagasaki.
AB  - The accuracy of death certificate diagnoses of cancer in the fixed population of
      about 100,000 samples in Hiroshima and Nagasaki was determined for the period
      1961 approximately 1970 by comparison with autopsy findings. In general, when the
      death certificate listed cancer as a cause of death it was found at autopsy in a
      high proportion of cases. However, cancer was not always reported on death
      certificates, indicating that cancer occurs more frequently than recorded by
      official mortality statistics. Older persons, persons who die at home, and
      persons with certain cancers are more likely not to have cancer named on their
      death certificates. It is estimated that in the 10,749 deaths occurring at home
      or in hospital, there were 32% more deaths due to cancer than certified on death
      certificates (3,095 vs. 2,345) and for persons aged 70 or more dying at home it
      is estimated there were 55% more stomach cancer (269 estimated vs. 174 listed)
      and 244% more lung cancer (141 estimated vs. 41 listed) than were certified on
      death certificates. The death certificate is not a good source of information for
      cancer of the cervix because many cases of this disease reported on death
      certificates as cancer of the uterus. This practice needs to be taken into
      account in the use of mortality data for cervical cancer in Japan.

PMID- 1017580
TI  - Predication of the effect of carcinostatic agents on tumor-bearing host by the
      sensitivity test using acid phosphatase activity in vitro.
AB  - For the purpose of predicting the effect of carcinostatic agents on tumor-bearing
      host in vitro, a sensitivity test of a drug in tumor bearers was developed. This
      test is based on the change in the specific activity of acid phosphatase of
      individual tumor and liver tissue, and the difference in them was used as an
      indicator of effectiveness. The value was called the "effective value." The
      present papar is concerned with the relationship between the effective value and
      effectiveness of the agents in rodents and man. The results showed that the
      effective value became higher with increasing concentration of Mitomycin-C
      incubated with tumor and liver tissues. The survival time of Ehrlich carcinoma
      bearing mice, which were given Mitomycin-C intraperitoneally, was longer and
      increase in the dose of Mitomycin-C. In ascitic or subcutaneous form of Ehrlich
      carcinoma, AH-130, and Yoshida sarcoma, the effective value was parallel with the
      survival time of or the inhibition of tumor growth in tumor-bearing animals
      treated with Mitomycin-C. In 25 patients with gastric carcinoma treated with
      Mitomycin-C, the postoperative survival time was more closely correlated with the
      effective value calculated by the titers of both tumor and liver than the value
      of tumor alone.

PMID- 1017581
TI  - Interaction of antitumor agents including carboquone in sarcoma-180 system.
AB  - Combination effect of antitumor agents including carboquone was evaluated on the
      concept of pharmacological synergism and not therapeutic synergism in ascites
      sarcoma-180 system. Combinations of carboquone plus cyclophosphamide,
      doxorubicin, and Methotrexate in simultaneous administration and carboquone plus
      doxorubicin in alternate one provided synergism. Combination effect of agents was
      affected by the schedule of drug administration. Toxicity of carboquone in
      combination with many antitumor agents, generally, decreased in simultaneous
      administration. Approved agents in combination with carboquone in simultaneous
      administration were Mitomycin-C, daunorubicin, Actinomycin-d, vinblastine,
      vincristine, Ancytabine, and 6-mercaptopurine. Those in alternate administration
      were Actinomycin-D and vinblastine.

PMID- 1017582
TI  - Antibody-dependent macrophage-mediated cytolysis in a murine syngeneic tumor
      system.
AB  - Peritoneal immune macrophages from C3H mice immunized against syngeneic MM46
      ascites tumor cells specifically lysed these tumor cells in the presence of
      immune sera in vitro. An active factor(s) essential for macrophage-mediated
      cytolysis was purified nonspecifically by gel filtration and then three types of
      ion-exchange column chromatography. One factor was a specific antibody belonging
      to the IgG2 a subclass. Neither immune macrophages nor the syngeneic antitumor
      antibody alone had a cytolytic action on the target cells. Thus, we named the
      reaction antibody-dependent immune macrophage-mediated cytolysis. The immune
      macrophages apparently destroyed the sensitized tumor cells in vitro by a
      nonphagocytic form of cell-contact and this type of cytolysis was independent of
      a complement. No evidence was obtained for a soluble cytotoxic factor released on
      interaction of immune macrophages with sensitized tumor cells. Living immune
      macrophages were essential for the cytolytic action and their activity depended
      on contractile microfilaments and protein synthesis as revealed by studies with
      specific inhibitors.

PMID- 1017583
TI  - Methylguanidine content in food.
AB  - A combination of column chromatography using microcrystalline cellulose and ion
      exchange resin, paper chromatography, gas chromatography, and gas chromatogrraphy
      mass spectometry was used to determine the content of methylguanidine in various
      meats of fish and animals, and their processed products. All the samples of fresh
      fish meat and beef analyzed contained trace amounts (0.2 approximately 0.9 ppm)
      of methylguanidine. Various types of dried or canned fish also contained trace
      amounts, while most of the "Bushi-rui," a highly processed dried meat of bonito,
      mackerel, or sardine contained 21 to 106 ppm of the compound. Two brands of
      peptone made by digesting meat probably with pepsin and trypsin also contained 12
      and 70 ppm of methylguanidine, respectively. Samples of ham, sausage, salami
      sausage, powdered skim-milk, and a few others did not contain any detectable
      amount (less than 0.2 ppm).

PMID- 1017584
TI  - Differentiation of host-mediated antitumor agents from mitotic posons by the
      antitumor foot-pad reaction in Ehrlich carcinoma-ddY mouse system.
AB  - The effect of antitumor agents (lentinan, PS-K, Mitomycin-C, 6-mercaptopurine,
      etc.) on the antitumor delayed hypersensitivity reaction (DHR) measured by the
      foot-pad test was compared with their effect on tumor growth in ddY mice with
      Ehrlich tumor. These agents all inhibited growth of Ehrlich carcinoma. Lentianan
      and PS-K enhanced the antitumor DHR, but Mitomycin-C and 6-mercaptopurine did
      not. By plotting the effect of agents on the anti-tumor DHR against these effects
      on tumor weight, host-mediated antitumor agents could be differentiated from
      mitotic poisons. Attempts to distinguish these two types of agents by the same
      method using a syngeneic tumor system were unsuccessful.

PMID- 1017585
TI  - Blastoid transformation of human lymphocytes cultured with protein-bound
      polysaccharide preparation, PS-K, in vitro.
AB  - The protein-bound polysaccharide preparation, PS-K, isolated from a mushroom,
      Coriolus versicolor, was found to stimulate human lymphocytes and induce them
      into blastogenesis in vitro. This stimulatory effect seemed to be nonspecific
      since lymphocytes from cord blood of newborn babies were also stimulated by PS-K.
      The highest lymphocyte blastogenesis by PS-K was observed after 5 days in
      culture.

PMID- 1017586
TI  - Micrometastasis in resected lungs of lung cancer patients.
AB  - In order to find causes for recurrence and/or metastasis after removal of human
      lung cancer, microscopic metastasis was examined histologically in the seemly
      unaffected areas of the lung in primary lung cancer patients. In 55 of 116 cases
      (47%), microscopic metastases were found in the areas of the lung which looked
      normal. These micrometastases were localized in 22 cases and disseminated in 33
      cases. The sites where tumor cells were growing were identified in lung tissue as
      blood vessels, lymphatics, and aerial spaces, although it was difficult to
      identify a few cases. The incidence of microscopic metastases was significantly
      lower in the lungs of the group in which the diameter of a tumor was less than 3
      cm, than those in which the diameter was more than 3 cm. In addition there was a
      significant decrease in the rate of microscopic spreads in the specimens without
      lymph node involvement as compared to those with lymph node involvement. The rate
      of postoperative recurrence and/or metastases was significantly high in the cases
      with micrometastasis compared to those without, suggesting that most of the
      microscopic spreads would become distinct tumors if unresected.

PMID- 1017587
TI  - Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil in a variety of
      experimental tumors.
AB  - Antitumor activity of 1-hexylcarbamoyl-5-fluorouracil against various tumors was
      examined. Therapeutic ratio (ILSmax/ILS30) in L-1210 system was 4.5 by oral
      administration, while those of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5
      fluorouracil were 1.9 and 1.0, respectively. Therapeutic ratio of the compound in
      C-1498 system was 11, while those of 5-fluorouracil and 1-(2-tetrahydrofuryl)-5
      fluorouracil were 3.3 and 2.5, respectively. 1-Hexylcarbamoyl-5-fluurouracil was
      also active against solid and ascites tumors by oral administration. It was
      markedly active against Nakahara-Fukuoka sarcoma, adenocarcinoma=755, and ascites
      sarcoma-180, and moderately active against Ehrlich ascites carcinoma. This
      compound had a wider tumor spectrum than 5-fluorouracil and 1-(2-tetrahydrofuryl)
      5-fluorouracil by oral administration.

PMID- 1017588
TI  - Further studies on the isozyme patterns of branched-chain amino acid transminase
      in cultured rat hepatocytes.
AB  - Among several lines of cultured rat hepatocytes examined, one line, IAR-22,
      contained enzyme III as well as enzyme I of the isozymes of branched-chain amino
      acid transaminase (EC 2.6.1.42) and this cell line was tumorigenic. None of the
      cell lines tested contained enzyme II (EC 2.6.1.6) or tyrosine transaminase (EC
      2.6.1.5) and addition of dexamethasone did not induce these transaminases. The PC
      1 line, containing only enzyme I and having a high percentage of diploid cells,
      showed deviation of its chromosomal number and tumorigenicity, but no change in
      its isozyme pattern when transformed with N-methyl-N'-nitro-N-nitrosoguanidine.
      Therefore, judging from expression of isozymes of the transaminase, this
      transformed cell line retained moderate differentiation.

PMID- 1017589
TI  - Possible important role of urinary N-methyl-N(3-carboxypropyl)nitrosamine in the
      induction of bladder tumors in rats by N-methyl-N-dodecylnitrosamine.

PMID- 1017590
TI  - Effect of enterohepatic circulation on bile production in regenerating liver.
AB  - In an investigation of the role of portal blood flow in bile production and of
      changes in the enterohepatic circulation of bile in the regenerating liver,
      various branches of the portal vein were ligated in dogs, bile was collected from
      the liver lobes supplied by ligated and by nonligated portal branches, and the
      composition of the bile was analyzed. 1. Bile flow and bilirubin excretion from
      the ligated, atrophic liver lobes decreased with a disappearance of glycine
      conjugated bile acids, but bilirubin excretion and especially bile flow increased
      greatly without any changes in bile acids composition in the nonligated,
      regenerating liver lobes as the portal blood flow to them per liver weight
      increased. 2. Infusion of gallbladder bile into the terminal ileum stimulated
      bile secretion in the nonligated lobes in the postoperative period, but not in
      the ligated lobes except immediately after the ligation of the portal vein
      branches supplying two-thirds of the liver. These findings indicate that bile
      secretion by the ligated lobes could be stimulated via the hepatic artery and the
      nonligated lobes might be via both the portal vein and the hepatic artery after
      the infusion during early postoperative period.

PMID- 1017591
TI  - Studies on the functional disturbances of the papillary region using a pressure
      sensor.
AB  - Investigation of the duodenal papilla and the bile duct by EPCG is essential to
      diagnose the organic and functional disturbances of the papillary region. We have
      developed a pressure sensor based on a semi-conductor in order to obtain a more
      objective observation of pathological conditions in the papillary region. Using a
      duodenofiberscope, the pressure sensor was placed on the tip of canula, and it
      was inserted into the papilla and measured the movements of the papillary region.
      The pressure sensor method was carried out in 18 normal subjects and 69 patients
      with various diseases. As the result of analysis of wave forms in normal
      subjects, regular wave form patterns were obtained. In about 71% of cases with
      biliary diseases irregular wave forms were observed. Irregular wave form patterns
      were also observed 40% of cases with cholecystolithiasis, while irregular
      patterns were revealed in 86% cases with choledocholithiasis. The pressure sensor
      method during for duodenofiberscopy is important diagnostic procedure for the
      determination of functional disturbances in the papillary region.

PMID- 1017592
TI  - Serum glycoproteins in the liver diseases. I. Studies on sialic acid-free
      glycoproteins-improved competitive binding assay of desialylated glycoprotein by
      rat liver plasma membrane.
AB  - An improved method for quantitation of desialylated glycoproteins was developed.
      The assay was carried out in non-saturating condition other than saturating
      condition which has been used by the other authors. In the present method a lower
      radioactivity in the assay solution can be used. Standard curves obtained by
      adding an increasing amount of desialylated alpha1-acid glycoprotein to the assay
      solution made it possible to measure desialylated glycoproteins equivalent to 5
      200 ng of desialylated alpha1-acid glycoprotein. Desialylated alpha1-acid
      glycoprotein used for the assay could be prepared in large scale by hydrolysis
      with 0.1 N-H2SO4.

PMID- 1017593
TI  - Serum glycoproteins in the liver diseases. II. Radioimmunoassay of alpha-1 acid
      glycoprotein.
AB  - A radioimmunoassay for human alpha1-acid glycoprotein has been developed. 97.8%
      of 125I-alpha1-acid glycoprotein prepared for the assay were immunoprecipitable
      with specific anti-sera against the protein. alpha1-acid glycoprotein
      concentration in sera from normal adults was found to range between 70 and 114
      mg/100 ml, with a mean of 93. Fulminant hepatitis, liver cirrhosis or chronic
      active hepatitis with sublobular necrosis caused a significant lowering of alpha1
      acid glycoprotein concentration. Sera obtained from patients with acute hepatitis
      in convalescence, chronic inactive hepatitis or primary biliary cirrhosis gave
      normal concentration of the glycoprotein.

PMID- 1017594
TI  - Gastric carcinoma combined with distant gastric ulcer.
AB  - The cases of the gastric carcinoma combined with distant benign gastric ulcer
      were 90 of 1257, 7.1%, and the carcinomas were frequently found in the lesser
      curvature of the antrum and the combined gastric ulcers frequently in the lesser
      curvature and posterior wall of the corpus. Average age in the combined cases was
      58.8 which was older about 7 years than that in the cases of the gastric ulcer.
      The cases, in which the ulceration in the gastric ulcer was same or deeper than
      that in the gastric carcinoma, occupied about 70% of these combined cases. It
      should be considered that the malignant transformation does not always occur in
      the preceding ulcerative lesion. However, the intestinal metaplasia was usually
      severe, and so the well-differentiated carcinomas were twice frequent to the low
      differentiated ones. The repeated regeneration of the epithelial cells associated
      with the erosive or ulcerative change may be of some relation to the
      carcinogenesis, because the intestinal metaplasia appears usually associated with
      the repeated defect and repair of the propria mucosae.

PMID- 1017595
TI  - Sibling cases of chronic recurrent hepatocerebral disease with
      hypercitrullinemia.
AB  - Two sibling cases with chronic recurrent hepato-cerebral syndrome which
      correspond to the nutritional form of hepato-cerebral disease entitled by Shikata
      et al. and the data of plasma free aminoacids analyses of these cases were
      reported. The one case is 27 years old male and the other case is 36 years old
      female. Their parents were cousins. Both cases have had unbalanced diet,
      especially liked legumes unusually. Their main symptom was recurrent disturbance
      of conciousness and convulsive seizures. Slight abnormality of liver function
      test and hyperammonemia were demonstrated. Electroencephalogram showed the
      pattern of triphasic wave. Coeliac angiography did not revealed a portal-systemic
      shunt. Hepatic biopsy specimen revealed liver fibrosis with fatty change in the
      one case and mild fatty change in the other case. Analyses of plasma free
      aminoacids showed particurally high level of citrulline in both cases. From the
      results of plasma free aminoacids analyses, it is considered that pathogenesis of
      these patients is congenital hereditary urea cycle disorders.

PMID- 1017596
TI  - The application of caerulein to cholangiography.
AB  - Caerulein was applied to oral cholecystography and the opacity of the common bile
      duct was evaluated at intervals. To 127 subjects whose gallbladder had been
      visualized by cholecystography was administered caerulein by intramuscular route
      in a dose of 0.2 mug per kg of body weight. As a result: 1. The visualization of
      the common bile duct reached its maximum 15 minutes after administration of
      caerulein (52% of the subjects); in total, 62.2% of the subjects responded to
      this cholecystography. 2. The visualization by caerulein was superior to that by
      the yolk both in its rate and intensity. 3. The cholangiogram taken after
      administration of caerulein was preferably available for diagnosis of bile duct
      lesions. Caerulein used for a pretreatment of drip infusion cholangiography (DIC)
      remarkably improved the picture in 3 of the 10 subjects in whom DIC alone had
      failed to show the bile duct. Thus, the application of caerulein to
      cholangiography facilitated diagnosis of bile duct lesions.

PMID- 1017597
TI  - Basic studies on cholesterol solubilization in bile salt solution.
AB  - Previous studies on cholesterol solubilization by bile salts have often shown
      inconsistencies. To obtain basic informations on this problem, cholesterol
      solubilization in the aqueous solution of several bile salts have been
      reexamined. Kinetic studies revealed that not only the rate but also the
      magnitude of solubilization depended on the amount of excess cholesterol and the
      concentration of bile salt. An appropriate proportion of added cholesterol to
      bile salt was evaluated as 1:5-10 (w/w), corresponding to about 200% excess
      amount to approximate supposed solubility. The solubilization equilibrium was
      rather difficult to fix and must be checked by the procedure used. A linear
      relation was obtained between the quantity of solubilized cholesterol and the
      concentration of bile salt. The slope of the straight line was designated k. As
      the solubilizing power could be given by the ratio of the solubilizate to the
      solubilizer, it was expressed numerically by k value as well as graphically by
      the molar ratio of cholesterol to bile salt as ordinate and the molar
      concentration of bile salt as abscissa in which the above relation was
      hyperbolic, k being as asymptote. k values obtained for cholate,
      chenodeoxycholate, deoxycholate and equimolar cholate-deoxycholate mixture were
      3.72 X 10(-2), 6.79 X 10(-2), 8.10 X 10(-2) and 6.55 X 10(-2) respectively.

PMID- 1017598
TI  - Studies on intestinal malabsorption in chronic pancreatitis.
AB  - Pancreozymin-secretin test (PS test) and intestinal absorption tests were
      performed in 21 patients with chronic calcific pancreatitis and 32 patients with
      chronic noncalcific pancreatitis to evaluate exocrine functions of the pancreas.
      And the following results were confirmed. (1) Fecal fat excretion increased in
      33% of chronic pancreatitis (47% of calcific pancreatitis and 25% of noncalcific
      pancreatitis). Serum carotene leves showed significantly low levels in 44% of
      chronic pancreatitis (67% of calcific pancreatitis and 27% of noncalcific
      pancreatitis). (2) D-xylose tolerance test was abnormally low in only 6% of
      chronic pancreatitis, but Schilling test was evaluated abnormally low in 29% of
      chronic pancreatitis (50% of calcific pancreatitis and 11% of noncalcific
      pancreatitis). (3) Fecal fat excretion increased in cases of severe exocrine
      insufficiency of the pancreas with decreased amylase output and decreased maximum
      bicarbonate concentration in PS test. (4) Correlation of fecal fat excretion to
      maximum bicarbonate concentration was statistically significant, but those to
      amylase output or volume of pancreatic juice were not significant. (5) Antacid
      drugs combined with pancreatic extracts seems to be indispensable in the
      treatment of chronic pancreatitis as far as malabsorption in chronic pancreatitis
      is concerned.

PMID- 1017599
TI  - A case of malignant reticulosis with chronic hepatitis.

PMID- 1017600
TI  - Effects of prenatal and postnatal exposure to LSD on brain maturation.

PMID- 1017601
TI  - Antagonism of glutamate and acetylcholine excitation of rat cerebral cortical
      neurones by diphenylhydantoin.

PMID- 1017602
TI  - Depression of drug metabolism in liver microsomes after treating rats with
      unsaturated fatty acids.

PMID- 1017603
TI  - Effect of stress on newborn hypothalamic phenylethanolamine-N-methyltransferase.

PMID- 1017604
TI  - [Air movements in middle high spaces in various kinds of ventilation].

PMID- 1017605
TI  - [Calculation of sun-radiation intensities for technical studies of warmth in
      house construction].

PMID- 1017606
TI  - [Characteristics of allergic pathology among the child population of an
      industrial center].

PMID- 1017607
TI  - [Embryotropic effect of dissociation products of herbicides based on 2,4
      dichlorphenoxyacetic acid].

PMID- 1017608
TI  - [Sanitary-toxicologic characteristics of butyl alcohol under conditions of
      prolonged inhalation].

PMID- 1017609
TI  - [Methods of calculating health standards for chemically polluted water].

PMID- 1017610
TI  - [10 years of water fluoridation in Ivano-Frankovsk].

PMID- 1017611
TI  - [Hygienic assessment of the anticorrosive hermatic AG-4 used in a hot water
      supply system].

PMID- 1017612
TI  - [Present principles for substantiating approximate innocuous levels of body
      exposure to chemical substances].

PMID- 1017613
TI  - [Hygienic assessment of tertiary adsorption purification of home and industrial
      sewage].

PMID- 1017614
TI  - [Hygienic assessment of the effectiveness of biological purification of sewage
      from sleeper treatment plants].

PMID- 1017615
TI  - [Criteria and methods of hygienic assessment of household chemicals].

PMID- 1017616
TI  - [Electroencephalographic studies of workers at computer centers during their
      work].

PMID- 1017617
TI  - [Possibility of optimizing the learning process using different teaching media].

PMID- 1017618
TI  - [Hygienic standards for training loads for swimmers in child-adolescent sports
      schools].

PMID- 1017619
TI  - [Several methodologic problems in elaborating hygienic aspects of environmental
      protection].

PMID- 1017620
TI  - [Principal tasks and ways of improving the preparation of health officers during
      the 10th five-year plan].

PMID- 1017621
TI  - [New curriculum of the sanitation-hygiene department].

PMID- 1017622
TI  - [Materials toward setting health standards for monoisopropyl and monobutyl esters
      of ethylene glycol in atmospheric air].

PMID- 1017623
TI  - [Photoplethysmographic method of measuring arterial pressure in rats].

PMID- 1017624
TI  - [Determination of serum ionized calcium].

PMID- 1017625
TI  - [Gas chromatographic determination of total concentration of organic substances
      using air as a gas-bearer].

PMID- 1017626
TI  - [Determination of asulam in air by the thin-layer chromatography method].

PMID- 1017627
TI  - [Photometric determination of the methyl ester of benzonesulfonic acid in the air
      of industrial premises].

PMID- 1017628
TI  - [Preliminary sanitary-chemical study of gas generation by polymeric materials].

PMID- 1017629
TI  - [Methods for optimizing conditions for radiometric and gamma-spectrometric
      biological tests with little activity content].

PMID- 1017630
TI  - [Use of paper and thin layer chromatography in hygiene research].

PMID- 1017631
TI  - [Sanitary supervision of swimming pools].

PMID- 1017632
TI  - [Unified information system for control of environmental conditions on the
      premises of large industrial complexes].

PMID- 1017633
TI  - [Sanitary and hygienic evaluation of the working conditions in a new type of
      hothouse].

PMID- 1017634
TI  - [Working posture of the operators of welding rigs].

PMID- 1017635
TI  - [Experience in operating stationary suction devices for taking atmospheric
      samples].

PMID- 1017636
TI  - [Some problems of measuring noise and studying its action on the body].

PMID- 1017637
TI  - [Dynamics of the work capacity and physiological indices of upper-class students
      in the course of the school year].

PMID- 1017638
TI  - [Working conditions of working pensioners].

PMID- 1017639
TI  - [Work experience of the Angarsk Branch of the All-Russian Society of Hygienists
      and Sanitary Physicians].

PMID- 1017640
TI  - [Importance of homology in setting hygienic standards for industrial pollutants
      in the water of reservoirs].

PMID- 1017641
TI  - [Hygienic evaluation of the effect of synthetic surface-active substances and
      detergents based on them (MS type) on the body].

PMID- 1017642
TI  - [Combined action of hypoxia, hypercapnia and hyperthermia].

PMID- 1017643
TI  - [Hygienic characteristics of rubbers containing N,N'-dithiodimorpholine and
      intended for contact with food products].

PMID- 1017644
TI  - [Tasks of work hygiene in the light of decisions of the 25th Congress of the
      CPSU].

PMID- 1017645
TI  - [Hygienic evaluation of the instructional regimen of vocational-technical school
      students].

PMID- 1017646
TI  - [Physiological and hygienic characteristics of the occupational training of hand
      molders].

PMID- 1017647
TI  - [Dynamics of certain functional indices of the children in a kindergarten].

PMID- 1017648
TI  - [Assessment of the degree of irradiation of individual organs in x-ray studies of
      the lungs].

PMID- 1017649
TI  - [Effect of organic solvents on Am241 penetration of the body via the skin].

PMID- 1017650
TI  - [Use of correlation-regression analysis for studying the effect of industrial
      hazards on the body].

PMID- 1017651
TI  - [Diffusion method of obtaining low concentrations of volatile substances in
      hygienic research].

PMID- 1017652
TI  - [Methods of determining lithium and cesium in environmental objects].

PMID- 1017653
TI  - [Gas chromatographic determination of carbon monoxide in the atmosphere using a
      flame ionization detector].

PMID- 1017654
TI  - [Photometric method for the separate determination of a number of mineral acids
      in the atmosphere].

PMID- 1017655
TI  - [Determination of propylene in the air by a paper chromatographic method].

PMID- 1017656
TI  - [Determination of mineral oils in water by a spectrophotometric method].

PMID- 1017657
TI  - [Hygienic characteristics of phosphanitelia atmosfernogo vozdukha].

PMID- 1017658
TI  - [Determination of petroleum products in the soil].

PMID- 1017659
TI  - [Use of the impression method in studying the distribution range of viable
      microorganisms].

PMID- 1017660
TI  - [Hygienic problems of protecting reservoirs from pollution by thermoelectric
      power stations].

PMID- 1017661
TI  - [Sr90 content in the bony tissue of the population of Slovakia].

PMID- 1017662
TI  - [Immunobiological reactivity of the body exposed to carbon monoxide and
      formaldehyde in the atmosphere].

PMID- 1017663
TI  - [Setting of "double" standards for chemical substances in the atmosphere].

PMID- 1017664
TI  - [Complex of air control tasks in enterprises in the Moscow ACU-sanitation
      system].

PMID- 1017665
TI  - [Hygienic evaluation of the operating efficiency of the purification structures
      of the Kharkov Tractor Factory].

PMID- 1017666
TI  - [Prevention of bacterial pollution of distilled water in the technological
      systems of pharmacies].

PMID- 1017667
TI  - [Basic principles and approaches for approval of experimentally established
      MPEL's for noxious substances in the air of working zones].

PMID- 1017668
TI  - [Natural silk as an occupational allergen].

PMID- 1017669
TI  - [Clinical picture and diagnosis of occupational bronchial asthma from exposure to
      formaldehyde containing polymers].

PMID- 1017670
TI  - [Assessment of immunologic reactivity of workers in the glass insulation and
      enameling divisions of a cable factory].

PMID- 1017671
TI  - [State of circulation in the limbs of patients with angiodystonic disorders of
      vibrational origin].

PMID- 1017672
TI  - [Antisilicotic effectiveness of polymers with tetra-substituted ammonia
      residues].

PMID- 1017673
TI  - [Comparative toxicity of chlorinated and fluorinated derivatives of the methane
      and ethane group].

PMID- 1017674
TI  - [Toxicology of esters of acrylic acid and higher aliphatic alcohols].

PMID- 1017675
TI  - [Causes of morbidity with occupational erysipeloid at a meat packing plant].

PMID- 1017676
TI  - [Protection of workers at high-frequency installations for induction heating].

PMID- 1017677
TI  - [Improving sanitary working conditions in the production of ammophos].

PMID- 1017678
TI  - [Results of testing a complex of measures to decrease the dustiness in facing
      combines PK-8M and 4PP-2].

PMID- 1017679
TI  - [5-Hydroxyindoleacetic acid as a biological test of lead absorption].

PMID- 1017680
TI  - [Results of a study of the allergic properties of viscose rayon].

PMID- 1017681
TI  - [Effect of an aerosol of calcined soda on the body (natural and experimental
      findings)].

PMID- 1017682
TI  - [Photometric method of determining lauroyl peroxide in air].

PMID- 1017683
TI  - [Improving sanitary working conditions and environmental protection at plants
      producing articles from metallic beryllium].

PMID- 1017684
TI  - [Sanitary-toxicologic classification of dangerous cargo].

PMID- 1017685
TI  - [Several results of scientific research with regard to occupational hygiene in
      the 9th five-year-plan].

PMID- 1017686
TI  - [Electromyographic studies in localized monotonous muscular tasks].

PMID- 1017687
TI  - [Comparative hygienic characteristics of working conditions with different
      technological methods of producing iodine from borehole water].

PMID- 1017688
TI  - [Clinico-electroencephalographic analysis of sleep disorders in several forms of
      occupational neurotoxicoses].

PMID- 1017689
TI  - [Genetic danger of the fungicide tsineb under production conditions].

PMID- 1017690
TI  - [General toxic effect of dusts from the production of crude nickel].

PMID- 1017691
TI  - [Growth of the economic effectiveness of expenditures for prevention of chronic
      occupational diseases in industry].

PMID- 1017692
TI  - [Hearing changes in persons working on electric locomotives].

PMID- 1017693
TI  - [Experience in improving the sanitary conditions of work in areas using the
      coolant fluid "Sul'fofrezol"].

PMID- 1017694
TI  - [5 cases of allergic myocarditis in workers in a cobalt department].

PMID- 1017695
TI  - [Basis for the MPEL of the terphenyls HTP, TPM and IPMTP in the air of the
      working area].

PMID- 1017696
TI  - [Effect of benzene on stem cell hematopoiesis].

PMID- 1017697
TI  - [Effect of tertiary butyl hydroperoxide on the body of the mother and fetal
      development].

PMID- 1017698
TI  - [Chromatographic means of determining several chemical substances from the
      production of isoprene rubber in the saliva of workers].

PMID- 1017699
TI  - [Experimental findings on the characteristics of primary responses of the body to
      hexamethylene diamine exposure].

PMID- 1017700
TI  - [Relationship between fractionation of the administered dose and coefficients of
      accumulation of bromorganic substances].

PMID- 1017701
TI  - [Polarographic determination of selenium and selenium dioxide in the air of
      industrial premises].

PMID- 1017702
TI  - [Effectiveness of physiologically rational intra-shift work schedules for miners
      of preparatory and cleaning faces of Donbass coal mines].

PMID- 1017703
TI  - [Physiologic-hygienic characteristics of the work of laborers in the chief
      occupations at wire plants].

PMID- 1017704
TI  - [Effect of multielectrolyte physiological solution on uterine contractility in
      labor].

PMID- 1017705
TI  - [Use of Fortral in perinatal analgesia].

PMID- 1017706
TI  - [Menstruation in diabetic girls].

PMID- 1017707
TI  - [Case of lateral sacculation of the uterine isthmus].

PMID- 1017708
TI  - [Advanced ectopic pregnancy].

PMID- 1017709
TI  - [Induction and stimulation of premature labor].

PMID- 1017710
TI  - Effect of intraluminal oxygen on experimental ischaemia of the intestine.
AB  - The small bowel of 44 rats has been made ischaemic for 120 minutes by occluding
      the superior mesenteric artery. Gaseous oxygen was introduced into the small
      bowel lumen of 18 of the rats, and gaseous nitrogen into the bowel lumen of a
      further eight, 30 minutes after the start of the ischaemia. The mortality rate of
      the control group of 18 rats was 89%, significantly higher than the 39% mortality
      of the oxygen-treated rats (p less than 0-005). None of the eight rats treated
      with intraluminal nitrogen survived. Histological changes caused by ischaemia
      were much reduced in the intestine of the oxygen treated rats. It is suggested
      that intraluminal oxygen might be useful additional form of therapy for the
      treatment of the partially ischaemic bowel that may be retained after the
      resection of definitely non-viable ischaemic bowel at initial laparotomy.

PMID- 1017711
TI  - Evidence for the mixing of residue in the human gut.
AB  - Mixing the residue in the gut has been studied in 24 normal subjects using five
      different types of radio-opaque pellets. By giving single doses of different
      pellets to the subjects on three successive days and measuring their appearances
      in the stool by radiographs evidence of mixing was found in 83% of studies. Mean
      transit time (MTT) of markers through the gut was measured from the single dose
      studies (MTT-S) and also by giving the pellets to subjects continuously with each
      meal (MTT-C). By comparing MTT-C with MTT-S evidence was found for a mixing pool
      with exponential decay. The turnover time of this pool was estimated as about 30%
      of the total MTT.

PMID- 1017712
TI  - Effect of motilin on the lower oesophageal sphincter.
AB  - The effect of motilin on lower oesophageal sphincter (LES) pressure has been
      studied in unanesthetised specially trained dogs using an infusion manometric
      technique. Motilin produced significant rises in resting pressure and
      contractions of the LES after doses ranging from 0-009 mug/kg to 0-05 mug/kg.
      Doses greater than 0-05 mug/kg resulted in repetitive high amplitude
      contractions. Atropine 30 mug/kg completely abolished the effect of the lower
      doses of motilin. Higher doses of motilin in atropinised dogs still caused a
      small rise in baseline pressure and contractile activity still appeared.
      Hexamethonium 2 mg/kg resulted in both a diminished rise in LES pressure and the
      disappearance of contractions after motilin. Hexamethonium and atropine together
      completely abolished the LES response to motilin. We conclude that motilin
      increases LES pressure by acting on preganglionic cholinergic neurones to release
      acetylcholine which excites other cholinergic neurones supplying the circular
      muscle of the LES.

PMID- 1017713
TI  - Responses of the competent and incompetent lower oesophageal sphincter to
      pentagastrin and abdominal compression.
AB  - Responses of the lower oesophageal sphincter (LOS) to pentagastrin, given by
      continuous intravenous infusion in doses ranging between 0 and 9 mug/kg/h, and to
      external abdominal compression were measured by infused catheters in healthy
      subjects and in a group of patients with reflux oesophagitis. In separate
      experiments, pressures were measured both by sensors stationary within the LOS,
      and by repeated continuous withdrawals of sensors from stomach to distal
      oesophagus. In normal subjects, doses of pentagastrin within the physiological
      range (0.9 mug/kg/h) produced modest but statistically significant increases in
      LOS pressure. By comparison, sphincteric responses in patients with oesophagitis
      were small and a dose of 4-5 mug/kg/h was the lowest that produced a significant
      increase in LOS pressure. During abdominal compression increases in LOS pressure
      did not significantly exceed increases in intragastric pressure in either
      patients or normal subjects. This was so at all doses of pentagastrin that were
      tested. Hence, there was no evidence of synergism between the effects of
      pentagastrin and abdominal compression upon the LOS. We infer from our findings
      that gastrin does play a modest role in the physiological regulation of human LOS
      tone. Relative insensitivity of the incompetent LOS to pentagastrin represents,
      we believe, sphincteric muscle failure. Our results are not consistent with the
      hypothesis that LOS incompetence is due to loss or impairment of an adaptive
      response of the LOS to alterations in intra-abdominal pressure.

PMID- 1017714
TI  - Pancreatitis--a retrospective study.
AB  - A retrospective study has been made of all adult patients admitted to Manchester
      Royal Infirmary with exocrine pancreatic disease between 1968 and 1974, in order
      to define the factors which influence the variable mortality and morbidity rates
      in published accounts of patients with acute pancreatitis. The most plausible
      explanation is that some series with low mortality rates include a variable
      number of patients with relapsing acute pancreatitis and acute exacerbations of
      chronic pancreatitis. Both these pathological entities have a negligible
      mortality and morbidity rate compared with single attacks of acute pancreatitis.
      The difficulties encountered by the clinician in determining the prognosis of
      acute pancreatitis at the time of admission to hospital are discussed. Attention
      is drawn to the differing role of alcohol as an aetiological factor in relapsing
      chronic pancreatitis and acute pancreatitis.

PMID- 1017715
TI  - Suppression of giardiasis during the intestinal phase of trichinosis in the
      mouse.
AB  - The interaction of the intestinal phases of Giardia muris and Trichinella
      spiralis was investigated in Swiss albino mice. Intraoesophageal inoculation of
      G. muris cysts seven days before, or seven days after, similar inoculation of T.
      spiralis larvae resulted in significant reduction in the numbers of Giardia
      trophozoites in small bowel and Giardia cysts in stools. This effect was not
      observed when G. muris cysts were administered after resolution of the intestinal
      phase of trichinosis. Giardiasis had no effect on trichinosis as assessed by
      numbers of adult worms in small bowel and larvae in skeletal muscles. Studies of
      small bowel morphology showed that the intestinal phase of trichinosis was
      associated with increased numbers of inflammatory cells in the lamina propria, a
      significant increase in Paneth cells in crypts, and a marked reduction in the
      villus:crypt ratio of jejunum. These observations suggest that the intestinal
      phase of trichinosis induced environmental changes in small bowel, perhaps
      related to inflammation, which resulted in suppression of proliferation of
      Giardia trophozoites.

PMID- 1017716
TI  - Galactose elimination capacity as a prognostic index in patients with fulminant
      liver failure.
AB  - In 25 patients with fulminant hepatic failure the prognostic value of a
      quantitative liver function test, the galactose elimination capacity, was
      assessed and comapred with routine liver function tests and clinical features.
      The galactose elimination capacity was significantly higher (P less than 0-05) in
      the five patients who survived than in the 20 patients who died. None of the
      other liver function tests, was significantly different. The values of the
      galactose elimination capacity overlapped considerably between survivors and non
      survivors, but all patients with a galactose elimination capacity below 12-8
      mumol galactose/min and kg body weight died. The disease among most patients who
      died having a galactose elimination capacity greater than 13 mumol ran a subacute
      course. It is suggested that quantitative liver function tests be included when
      new treatments of fulminant hepatic failure are investigated.

PMID- 1017717
TI  - Idiopathic bile acid catharsis.
AB  - In the course of extensive routine screening for bile acid malabsorption a few
      patients were detected in whom chronic diarrhoea was apparently induced by excess
      bile acid loss which was neither associated with demonstrable conventional
      ileopathy nor with any other disorder allied to diarrhoea. In three patients
      subjected to scrutiny the results obtained were in harmony with a concept of
      idiopathic bile acid catharsis. Ingestion of cholestyramine was followed by
      immediate relief, but the diarrhoea recurred whenever this treatment was
      withdrawn. It it suggested that idiopathic bile acid catharsis should be
      suspected in patients with unexplained chronic diarrhoea and especially in those
      with a diagnosis of irritable colon with diarrhoea.

PMID- 1017718
TI  - Intravenous administration of diazepam in patients with chronic liver disease.
AB  - The EEG response and drug kinetics after intravenous infusion of diazepam at 1-0
      mg/min until nystagmus, dysarthria, and moderate sedation developed, has been
      investigated in five normal subjects and 17 patients with chronic liver disease.
      Diazepam induced adequate premedication with a similar clinical response in all
      subjects with no adverse reactions. Maximal response was during or within five
      minutes of infusion. The dose of diazepam required in liver chronic disease was
      17-9 +/- 1-4 mg (M +/- SEM) compared with 27 +/- 5-4 mg in controls (p less than
      0-01). Dose correlated significantly with serum albumin (p less than  0-05).
      Baseline mean dominant frequency (MDF) and slow wave index (SWI) significantly
      correlated with albumin (p less than 0-01). After diazepam, the MDF decreased and
      SWI increased. The change was greatest at the time of maximal clinical response.
      It was greater in liverdisease and was greatest in patients with previous
      hepaticencephalopathy. In spite of reduced dose requirements in liver disease,
      there was no significant difference in plasma concentration at the end of drug
      infusion...

PMID- 1017719
TI  - Patchiness and duodenal-jejunal variation of the mucosal abnormality in coeliac
      disease and dermatitis herpetiformis.
AB  - The incidence and degree of patchiness of mucosal abnormality in both coeliac
      disease (CD) and dermatitis herpetiformis (DH) is documented. As judged by both
      stereomicroscopy and subjective histology, patchiness occurred frequently in both
      CDand DH patients. In most cases the difference of abnormality was of only one
      grade, but in approximately 25% as assessed by stereomicroscopy and 10% as
      assessed by histology the difference was of two or more grades. In control
      subjects with normal small bowel mucosa the variation of the mucosal appearance
      between the duodenum and proximal jejunum was studied. Contrary to popular
      belief, no significant difference of villous and crypt measurements or of
      apparent villous "bridging" and "branching" between these two sites was found, if
      only well-orientated sections were studied. The stereomicroscopic appearances
      were also similar at these two sites, although villi tended to be broader in the
      duodenal biopsies. The duodenal-jejunal variation was also studied in CD and DH
      patients and although by both stereomicroscopy and subjective histology the
      appearances were similar in most patients, in approximately 33% the duodenal
      abnormality was the most severe and, surprisingly, the jejunal abnormality was
      more severe in approximately 15%. It is concluded that multiple, precisely
      located biopsies of both the duodenum and proximal jejunum are invaluable in the
      investigation of small bowel disease and in assessing response to treatment.

PMID- 1017720
TI  - Potential difference across the normal and the abnormal gastric mucosa in man.
AB  - The mucosal potential difference in the body of the stomach was measured in 18
      patients with gastric ulcers, five with gastritis, and three with pernicious
      anaemia. The results were compared with those of 12 normal volunteers.
      Significantly lower than normal levels were found in the groups of patients with
      gastric ulcers and gastritis. The patients with pernicious anaemia had even lower
      potential differences. In an additional 25 subjects, measurements were made in
      the duodenal bulb and at five sites in the stomach under direct vision at
      endoscopy. Biopsies were taken from each site for histology. Subjects with
      gastritis at the high lesser curve had a significantly lower potential difference
      at that site than those without gastritis. In the latter group, the potential
      difference at the high lesser curve was as low as in the antrum, and invariably
      lower than at the high greater curve.

PMID- 1017721
TI  - Predictive value of perioperative gastric acid tests.
AB  - Preoperative acid studies and early postoperative insulin tests in 275 patients
      undergoing various forms of vagotomy have been related to recurrent ulceration.
      Follow-up time has been from two to nine years, mean 4-3 years. Recurrence is
      directly related to basal acidity in both tests but is not related to stimulated
      acid levels preoperatively. In the insulin tests higher levels of acidity after
      insulin are associated with a higher incidence of recurrence. When positive,
      Hollander's and multiple criteria are both associated with a higher recurrence
      rate.

PMID- 1017722
TI  - Antifactor Xa activity measured with amidolytic methods.
AB  - Methods for the assay of antifactor Xa activity in the presence and absence of
      heparin are described. Diluted plasma is incubated with bovine, activated factor
      X (Xa) in stage I, and remaining Xa is measured with the chromogene substrate Bz
      Ile-Glu-Gly-Arg-pNA in stage II. In the presence of heparin, the inactivation is
      completed in 30 sec, and this method measures total Xa-inactivating capacity in
      diluted plasma (Method I). In a clincal material, this capacity showed a strong
      positive correlation (r=0.85) to the thrombin-inactivating capacity of diluted
      heparinized plasma (heparin cofactor activity) and apparently reflects
      antithrombin III (At-III) concentration. In the absence of heparin, the
      inactivation of factor xa occurs slowly. With an incubation of 5 min, about 25%
      of Xa is inactivated, and this assay reflects initial inactivation of Xa (Method
      II). With this method, a positive, but less strong correlation to the thrombin
      inactivating capacity was found (r=0.58), indicating that inhibitors different
      from At-III accounts for a minor part of the initial inactivation. Determinations
      in plasma, in which At-III was removed by immunoadsorption, indicated that At-III
      accounts for about 80% of the initial inactivation. The results of the assays are
      not significantly influenced by varying concentrations of fibrinogen, fibrinogen
      degradation products or heparin in the test plasma.

PMID- 1017723
TI  - Evaluation of hypercoagulability in septic abortion.
AB  - Soluble fibrin monomer complexes (SFMC) were determined in patients with septic
      abortion (body temperatures of more than 39 degree C and/or chills without
      apparent signs of endotoxic shock), with infected abortion, with non-infected
      abortion and with normal pregnancies. Quantitative gel filtration (4% agarose) of
      beta-alanine precipitated plasma samples yielded the relative (percent of total
      fibrinogen content) and absolute (mg/100 ml plasma) amount of SFMC. The relative
      (5.5+/-1.4%, mean+/-SD) and absolute (21.5+/-8.6 mg/100 ml) amount of SFMC was
      significantly increased in patients with septic abortion compared to patients
      with normal pregnancies or non-infected abortion (p less than 0.001). Patients
      with infected abortion (p less than 0.001). Patients with infected abortion
      already revealed increased levels of SFMC (4.3+/-1.2%, 14.2+/-6.8 mg/100 ml)
      though their platelet count was still unaltered (infected abortion: 221+/-47 X
      10(3) platelets/mm3; septic abortion; 99+/-36 X 10(3) platelets/mm3). The use of
      heparin in patients with septic abortion resulted in a decrease in SFMC. Chain
      characterization of SFMC frequently revealed a slight degradation of the alpha
      chains probably due to fibrinolytic activity in vivo; gamma-gamma dimers
      representing intermolecular covalent bindings were not observed. The findings are
      in agreement with our former assumption that patients with septic abortion have a
      pronounced state of hypercoagulability.

PMID- 1017724
TI  - A technique for the evaluation of platelet-collagen adhesiveness in vitro.
AB  - A method for the evaluation in vitro of platelet-collagen adhesiveness has been
      developed. This method is based on counting platelets both before and after their
      contact with an insoluble collagen (IC) suspension. The results are expressed as
      adhesiveness index (AI). A number of variables which could influence the test has
      been evaluated and standardized in a way suitable for the routinary use of the
      technique described.

PMID- 1017725
TI  - Coagulation defect in experimental trypanosomial infection.
AB  - Some coagulation parameters have been studied in animals experimentally infected
      with trypanosomial organisms (T. brucei or T. congolense). The partial
      thromboplastin time test with kaolin was regularly abnormally prolonged in all
      animals during infection. Although results of some coagulation factors in the
      intrinsic pathway cannot be used to explain this finding, it is suggested that
      the partial thromboplastin time test can be used as a test to monitor infection
      and recovery from this organism.

PMID- 1017726
TI  - Treatment of thrombosis by sequential therapy with ancrod followed by
      streptokinase. Clinical pharmacology and rheology.
AB  - The effects of sequential therapy with ancrod followed by streptokinase are
      reported in a series of patients with thrombotic disease. Measurements have been
      made in blood coagulation, fibrinolysis and whole blood and plasma viscosity.
      Intravenous infusion of ancrod resulted in a significant reduction in plasma
      fibrinogen which was associated with highly significant reduction in both plasma
      and whole blood viscosity. Sequential therapy with streptokinase resulted in a
      gradual rise in fibrinogen and a slight but significant rise in whole blood and
      plasma viscosity. All patients showed clinical improvement and no haemorrhagic
      complications resulted.

PMID- 1017727
TI  - Distribution and variation of fibrinolytic activity in the walls of human
      arteries and veins.
AB  - A systematic study on the location and intensity of the fibrinolytic activity in
      more than 500 samples of human arteries and veins from 50 routine necropsies and
      35 blood vessel biopsies was performed. Data were obtained for an overall
      comparison of the fibrinolytic activity along and across the walls of human blood
      vessels by the use of a standardized fibrin slide technique. Arteries generally
      showed little or no fibrinolytic activity in the intima and media but strong
      activity in the adventitia. Veins showed a comparable strong fibrinolytic
      activity in the external layer of loose connective tissue. Fibrinolytic activity
      in the venous intima, media and adventitia was generally weaker but varied
      greatly according to position in the body. Veins situated in the lower parts of
      the body had less fibrinolytic activity than the veins at the upper levels.
      Fibrinolytic activity was found to be related to the endothelium of the vasa
      vasorum and/or of the main lumen of the vascular wall. Increased fibrinolytic
      activity was observed in arteries and veins in cases of sudden death, vasogenic
      shock, cerebral hemorrhage and cirrhosis. Decreased fibrinolytic activity was
      encountered in blood vessels in cases of endotoxin shock, hyaline membrane
      disease and a case of Waterhouse-Friderichsen syndrome.

PMID- 1017728
TI  - [Total pancreatectomy].

PMID- 1017729
TI  - [Celiac disease].

PMID- 1017730
TI  - [Ectopic thyroid in two children].

PMID- 1017731
TI  - [Treatment of migraine by an antiprostaglandin].

PMID- 1017732
TI  - [Cholelithiasis in childhood].

PMID- 1017733
TI  - [Extra-adrenal pheochromocytoma].

PMID- 1017734
TI  - [Latero-abdominal spigelian hernia].

PMID- 1017735
TI  - [Pemphigus sudaminosus].

PMID- 1017736
TI  - [War eye injuries with special reference to foreign bodies. Part III: invasive
      traumata].

PMID- 1017738
TI  - [Posture changes in childhood].

PMID- 1017737
TI  - [Fetal monitoring in a diabetic].

PMID- 1017739
TI  - [Joint symtoms in hyperparathyroidism].

PMID- 1017740
TI  - [Laboratory techniques in brucellosis].

PMID- 1017741
TI  - [Television and juvenile delinquency].

PMID- 1017742
TI  - [Epidemiologic studies as the basis for the planing of prevention and treatment
      of cardiovascular diseases].

PMID- 1017743
TI  - [Epidemiology of cardiovascular diseases. Study of urban population in the City
      of Cracow].

PMID- 1017744
TI  - [Coronary pain in the inhabitants of Cracow in the light of epidemiologic
      studies].

PMID- 1017745
TI  - [Epidemiological suspicion of past myocardial infarct in the population of
      Cracow].

PMID- 1017746
TI  - [Epidemiology of intermittent claudication in the population of Cracow].

PMID- 1017747
TI  - [Hypertension in the population of Cracow. An epidemiological study].

PMID- 1017748
TI  - [Nutritional conditions among the inhabitants of Cracow].

PMID- 1017749
TI  - [Epidemiological analysis of smoking habits as the main factor of
      arteriosclerosis risk].

PMID- 1017750
TI  - [Incidence of disorders of the Q wave, the S-T segment and the T wave in the
      population of Cracow].

PMID- 1017751
TI  - [Incidence of electrocardiographic rhythm and conduction disorders in the
      population of Cracow].

PMID- 1017752
TI  - [Selected cardiovascular diseases in the population of Cracow evaluated
      subjectively (Buerger's disease, valvular heart disease, myocarditis)].

PMID- 1017753
TI  - [Current cardiologic situation of theinhabitants of Cracow in the light of
      epidemiological studies].

PMID- 1017754
TI  - First record of bacillary rickettsia-like organisms in European tick Dermacentor
      marginatus (Sulzer).
AB  - Bacillary rickettsia-like organisms (BRLO) were found in the tick Dermacentor
      marginatus. They are gram-negative and differ from common bacteria and
      reckettsiae both in the cultivation conditions and morphology. BRLO are non
      pathogenic for ticks and guinea pigs. In our studies they were isolated on half
      engorged females of D. marginatus, on which they are still maintained.

PMID- 1017755
TI  - Observations on the development of Rhabdochona phoxini Moravec, 1968 (Nematoda:
      Rhabdochonidae).
AB  - The life-cycle of the nematode Rhabdochona phoxini, an intestinal parasite of the
      fish Phoxinus phoxinus, has been studied experimentally. The mayfly nymphs,
      Habrophlebia lauta Eaton and H. fusca (Curtis) were found to serve as
      experimental intermediate hosts. After the eggs of R. phoxini have been swallowed
      by the mayfly nymph, the toothed first-stage larvae of this parasite are released
      and penetrate through the intestinal wall into t-e body cavity of the mayfly.
      Before reaching the infective third stage, the larvae moult twice in the body of
      the invertebrate host (2 to 16 and20 to 36 days after infection at water
      temperatures of 13--15 degrees C). However, the development of the encysted
      infective larvae does not cease in the intermediate host and the larvae may
      undergo one more moult. One of two moults then occur in the intestine of the
      definitive host (Phoxinus phoxinus) (depending on the fact whether it was
      infected with third- or fourth-stage larvae) before the larvae attain the
      maturity. The development of R. phoxini in the definitive host lasts about two
      months.

PMID- 1017756
TI  - Morphological determination of the age of Cysticercus bovis in very young calves
      with cysticercosis.
AB  - Characteristics and measurements are given for early developmental stages of
      Cysticercus bovis. The data emerging from our study indicate that the age of a
      one to two month-old larva from a spontaneous infection can reliably be
      determined in histological sections. On these grounds we have been able to
      determine that the cysticercus infection in the two calves (aged 21 and 27 days
      respectively) had been acquired prenatally.

PMID- 1017757
TI  - Influence of microclimate on the life cycle of the common tick Ixodes ricinus
      (L.) in thermophilic oak forest.
AB  - Under conditions of the South Moravian thermophilic oak forest (Valtice near
      Breclav), the life cycle of the common tick Ixodes ricinus was studied by
      continuous recording of main elements of microclimate (temperature and humidity)
      in three different biotopes: forest, margin of the forest and meadow.
      Simultaneously conditions and the process of tick hibernation were studied in
      four soil layers (surface, depths of 10, 20 and 30 cm). Observations made in the
      winter and vegetation periods were assessed by mathematical-statistical tests.
      Results obtained in the forest biotope and at its margin are presented in this
      paper; results from the meadow biotope will be published separately.

PMID- 1017758
TI  - On the regularities of distribution of Hypoderma bovis De Geer larvae
      parasitizing cattle herds in different parts of the range of this warble fly.
AB  - The type and parameters of the distribution of the second and third instar larvae
      of Hypoderma bovis in cattle herds in Czechoslovakia (54 herds, 7233 head),
      Mongolia (20 herds, 1809 head) and the USSR (48 herds, 4978 head) were studied. A
      statistical analysis showed a) that in the majority of cases negative binomial
      distribution serves as a model of the distribution of larvae with sufficient
      reliability; b) that the regularity of dependence of the distribution exponent k
      of the negative binomial distribution on the incidence of infestation remains
      constant in different parts of the range of this warble fly. The latter fact
      indicates that the regulatory systems limiting the population numbers of this
      warble fly are associated with host-parasite relationships and do not depend on a
      complex of conditions specific for various natural zones. In order to understand
      the regulatory processes in parasite populations it is necessary to study equally
      the regulatory mechanisms operating primarily on  the level of specimens as well
      as the regulatory systems operating on the level of populations.

PMID- 1017759
TI  - Some contemporary aspects of natural focality and epidemiology of tick-borne
      encephalitis.

PMID- 1017761
TI  - A biofeedback study of postural sway.
AB  - An experiment was performed to control postural sway under auditory and visual
      feedback signals using a new apparatus. The subjects of 52 healthy high school
      girls were divided into 13 small groups. Each small group had four subjects who
      were assigned to one of the following four groups; 1) visual feedback group, 2)
      auditory feedback group, 3) auditory and visual feedback group, and 4) control
      group. Comparisons were made as to the duration of the green lamp being on, which
      indicated sway stayed around the initial central gravity. The results showed that
      auditory and visual feedback groups had a significant increase in the duration as
      compared to other three groups. With regard to the changes in the areas of
      postural sway, the largest increase was seen in the auditory and visual group.
      While the three feedback groups showed downward curves, the control group showed
      an upward one. Thus it is suggested that postural sway can be voluntarily
      controlled by a combination of an auditury feedback procedure and a visual
      feedback procedure, but not be either of them independently.

PMID- 1017763
TI  - Juvenile polyneuropathy due to vitamin B1 deficiency-clinical observations and
      pathogenetic analysis of 24 cases.

PMID- 1017764
TI  - Effects of electrical stimulation of the substantia nigra on responses of lateral
      geniculate body neurons to light.
AB  - Effects of electrical stimulation of substantia nigra on responses of the lateral
      geniculate neurons to light were studied. Responses of the neurons to flash were
      enhanced or inhibited by conditioning stimulation of the substantia nigra.
      Enhancement of firing by nigral stimulation more often occurred in neurons
      excited primarily by flash, but inhibition was more commonly observed in those
      which showed a primary neuronal silence after light.

PMID- 1017766
TI  - Acute and short-term toxicity studies on erythrosine BS in rodents.

PMID- 1017767
TI  - Short-term toxicity of erythrosine BS in pigs.

PMID- 1017768
TI  - Studies on the absorption, distribution and excretion of citral in the rat and
      mouse.

PMID- 1017769
TI  - Influence of dietary nitrate on nitrite content of human saliva: possible
      relevance to in vivo formation of N-nitroso compounds.

PMID- 1017770
TI  - The effect of nitrate intake on nitrite formation in human saliva.

PMID- 1017771
TI  - Some effects of dietary citric acid in small animals.

PMID- 1017772
TI  - Tannic acid: acute hepatotoxicity following administration by feeding tube.

PMID- 1017773
TI  - Mycotoxicosis produced in mice by cultural products of an isolate of Aspergillus
      ochraceus.

PMID- 1017774
TI  - Comparative metabolism of dieldrin in the rat (CFE) and in two strains of mouse
      (CF1 and LACG).

PMID- 1017775
TI  - Histochemical and biochemical studies of chemically induced acute kidney damage
      in the rat.

PMID- 1017776
TI  - 2,3,7,8-tetrachlorodibenzo-p-dioxin elimination in the rat: first order or zero
      order?

PMID- 1017777
TI  - Pharmacokinetics: first order or zero order.

PMID- 1017778
TI  - Pharmacokinetics: first order or zero order.

PMID- 1017779
TI  - A dental care model for the United States with comparative data.

PMID- 1017780
TI  - Rural health care research: past accomplishments and future challenges.

PMID- 1017781
TI  - Accountability: a critical dimension in health care.
AB  - The intent of this paper has been to present the notion that the public's demands
      for accountability present health professionals with unprecedented opportunities.
      Good health is the bedrock upon which social progress, personal attainment, and
      individual happiness are built. If health professionals are personally
      accountable and if they work cooperatively, they can transform the energy now
      expended in lamenting about crises of confidence, crises of control, and crises
      of performance into positive action directed toward improving the nation's
      health. Their rewards will indeed be great.

PMID- 1017782
TI  - Health care from a behavioral-ecological viewpoint.
AB  - While the intended thrust of this paper has been to elicidate the tremendous
      potential of the behavioral-ecological perspective for health care research and
      application, the intent has not been to underplay the important role of the
      biological sciences in the same venture. However, it is my contention that a
      behavioral-ecological approach to the study of health care has been widely
      neglected in health care functions and research. In terms of conventional
      research designs and terminology, the behavioral-ecological research implications
      can be summarized as follows: a behavioral-ecological perspective of health care
      research suggests research that is experimental rather than correlational
      descriptive; that focuses, because of its naturalistic thrust, on external
      validity more than internal validity; that incorporates as independent design
      variables the environmental context in which health behaviors occur; and that
      allows single-subject as well as multiple-group designs as research strategy.
      Finally, in terms of dependent variables, the research design requires a clear
      identification of the observable characteristics of the target health behaviors
      under consideration. In summary, health research geared toward professional goals
      appears to profit significantly from an ecological-behavioral approach which
      provides a model of high explication, specificity, and objectivity for knowledge
      generation and immediate application.

PMID- 1017783
TI  - Conflict and conflict resolutions: theories and processes relevant to the health
      profession.

PMID- 1017784
TI  - Predictive nursing: the baby and parents.
AB  - Predictive nursing as a health care strategy is not entirely new. What is new and
      emerging are means of sharpening our assessments of the events and conditions
      that support health, as well as specific models engaging the individual in
      assessing and altering or maintaining his position on the health continuum. This
      study has been shared with the readers to provide an encouraging direction toward
      new modes of health care delivery. We believe it is the most encouraging strategy
      for assisting families in promoting optimal health of infants from a very early
      point in the infant's life. The assessment techniques discussed in this paper
      relate to methods of identifying individual behavior patterns of newborn infants,
      behavioral interaction patterns of parents and infants during the early months
      and years of life, and the parents' perception of the infant. All of these
      measures are now being tested by the Nursing Child Assessment Project staff and
      will result in a systematic format of screening and assessing infants and
      families "at risk". With current knowledge, astoundingly correct predictions
      about cognitive development and achievement at school age of groups of children
      can be made with information about the mother's levels of education and the
      events of the perinatal periods. The measures discussed in this article
      concerning the infants' behavior, parent-child interaction, and the parents'
      perception of the child are factors which will go beyond our present ability to
      identify potential problems early. Predictive nursing of the infant and young
      child is our eventual goal. This means going a step beyond the current level of
      practice by beginning to systematically identify the proneness of individuals to
      good or bad health outcomes--specifically, the proneness of children to have
      developmental delays or problems--and to then provide a meaningful type of
      intervention before the developmental problem occurs.

PMID- 1017785
TI  - Observations of a health and healing system in a Papago community.
AB  - The Papago people in the Tohono village have a repertoire of culturally stylized
      patterns of behavior to help them maintain their health. The use of foods and
      ceremonies for preventing illness and maintaning health are emphasized in the
      styles of the people as well as the concept of taking care of self and others.
      Comfort and discomfort, fatigue, aches, thirst, hunger, and sadness are daily
      experiences of the people. Laughter, crying, "taking care of self and others",
      walking slowly, eating beans and tortillas, maintaining calm thoughts, and so on,
      are all culturally defined patterns for coping with alterations in feeling. When
      professional healers are needed, they will be consulted according to how helpful
      people perceive these healers to be by their sensitive attitudes and actions. The
      medicine man, nurses, medicine ladies, the ladies-who-pray, physicians, and St.
      Francis are perceived to be members of the health care team for the Papago
      people. The meaningful patterning of culturally defined behavior must be
      understood within the context of the Papago cultural system. As illustrated by
      the Tohono, "taking care of self and others" is highly valued, but it is only
      meaningful as we understand the rules of the Papago society, particularly the
      religious and kinship systems. These systems tell us that family members are
      important in taking care of themselves and others. Thus, the description in this
      paper of culturally patterned health practices with their rituals, ceremonies,
      and ways to help maintain health and heal the sick help the reader to understand
      the importance of health and healing behaviors within a designated cultural
      context. In this study, it is the Papago community and their specialty life ways
      of maintaining health and preventing illnesses.

PMID- 1017786
TI  - Towards conceptualization of transcultural health care systems: concepts and a
      model.

PMID- 1017787
TI  - Of wine and bottles, old and new: an anthropological perspective on the "new"
      family physician.

PMID- 1017788
TI  - Gaining awareness of cultural difference: a case example.

PMID- 1017789
TI  - Cognitive analysis and decision-making in medical emergencies.

PMID- 1017790
TI  - Oestradiol receptors in non-neoplastic gynaecomastic tissue of phenotypic males.
AB  - Cytoplasmic oestradiol receptors have been reported in breast tumor tissue but
      not in the uninvolved tissue from the same patients. Since gynaecomastic tissue
      is highly predisposed to neoplastic transformation, such receptors were looked
      for in this tissue from 13 phenotypic males of whom 6 had Klinefelter's syndrome.
      High affinity saturable binding (Kd approximately 10(-10) M) of 3H-oestradiol-17
      beta was found in the breast tissue from 12 of these patients by gel elution and
      dextran-coated charcoal techniques. The concentration of binding sites were found
      to range from 16 to 359 fmol/mg cytosol protein. Previous studies by the present
      authors showing steroid aromatising capacity and the present finding of specific
      oestradiol receptors in a 'high-risk tissue' in the absence of any histologically
      detectable neoplasms might be relevant in elucidating the natural history of
      breast cancer in such individuals.

PMID- 1017791
TI  - Radioimmunoassay for non-suppressible insulin-like activity.
AB  - By immunizing rabbits--tolerant against the bulk of normal human serum proteins-
      with highly purified non-suppressible insulin-like activity (NSILA-S), an
      antiserum was obtained which made possible the development of a double-antibody
      radioimmunoassay. Its sensitivity is about 30 pg NSILA-S per tube or 150 pg NSILA
      S/ml. The specificity exceeds that of the bioassay used for comparison which is
      based in the stimulation by NSILA-S of 125IUDR incorporation into chicken
      fibroblasts in culture. The radioimmunoassay is sufficiently sensitive and
      specific to allow direct NSILA-S measurement in serum or plasma samples of humans
      and experimental animals. In human plasma samples NSILA-S levels, carrying
      between less than 0.15 and 25 ng/ml , were found to have an average of about 4
      ng/ml. In rats higher levels were observed with a mean of 7.7 ng/ml in 4-week-old
      animals, increasing to about 60 ng/ml in 6-month-old rats. In fasting rats the
      NSILA-S plasma level is reduced. In acid-treated samples of plasma considerably
      higher NSILA-S amounts are found.

PMID- 1017792
TI  - Polymorphonuclear leucocyte function in hypothyroidism.
AB  - The quantitative nitroblue-tetrazolium test demonstrated that polymorphonuclear
      leucocytes from patients with hypothyroidism reduced the dye less well than
      leucocytes from euthyroid persons. The ability of these cells to ingest and kill
      staphylococci were unimpaired. The abnormality of the nitroblue-tetrazolium test
      in hypothyroid patients was corrected after their treatment with thyroxine.

PMID- 1017793
TI  - Failure of cyprohepatdine to inhibit vasopressin-stimulated cortisol release in a
      patient with Cushing's disease.
AB  - A case of a 21-year-old woman with Cushing's disease due to a pituitary tumor is
      described. The patient was treated with cyprohepatadine for 4 weeks immediately
      following pituitary alpha-particle irradiation. A standard vasopressin test to
      measure ACTH-mediated cortisol release was performed four times: prior to
      pituitary irradiation, after irradiation, after 4 weeks of cyproheptadine
      therapy, and off cyproheptadine for 2 weeks. Cyproheptadine failed to modify
      vasopressin-stimulated cortisol release in the patient described. This study
      suggests that cyproheptadine, which has previously been shown to decrease ACTH
      secretion, probably acts principally at the hypothalamic, rather than at the
      pituitary level.

PMID- 1017794
TI  - [Basic peptides in bee venom, II. Synthesis of two pentapeptides from the
      sequence of the mast-cell-degrading peptide (author's transl)].
AB  - The synthesis of two protected pentapeptides is described. The peptides are
      fragments of the sequence of a mast-cell degranulating peptide from bee venom.
      The fragments Boc-Lys(Z)-Ile-Cys(SiPr)-Gly-Lys(Z)(I) and Boc-Pro-His(Trt)-Ile
      Cys(Trt)-Arg(Tos) (II) were synthesized conventionally. The deprotection of the
      alpha-amino group by HCl/acetic acid of Boc-Ile-Cys(SiPr)-Gly-Lys(Z) was
      accompanied by a disulfide exchange at the cysteine residue. After the hydrolysis
      of fragment II with 6N HCl, allo-isoleucine could be detected by gas
      chromatography and amino-acid analysis.

PMID- 1017795
TI  - [An enzymic assay for the determination of vitamin B12 (author's transl)].
AB  - A procedure which extends the very sensitive propanediol-dehydratase reaction for
      5'-deoxy-5'-adenosylcobalamine determination to cyanocobalamine and
      hydroxocobalamine is described. In this procedure, the cobalamines are
      adenosylated by vitamin B12 coenzyme synthetase and the resulting 5'-deoxy-5'
      adenosylcobalamine can be determined by the propanediol-dehydratase reaction.
      Aldehyde, the product of the latter, can be registered by the alcohol
      dehydrogenase reaction.

PMID- 1017796
TI  - Neuraminic acid derivatives newly discovered in humans: N-acetyl-9-O-L
      lactoylneuraminic acid, N,9-O-Diacetylneuraminic acid and N-acetyl-2,3-dehydro-2
      deoxyneuraminic acid.
AB  - The free and glycosidically bound acylneuraminic acids from human serum and
      saliva and the free acylneuraminic acids from human urine have been characterized
      by thin-layer chromatography and gas-liquid chromatography/mass spectrometry.
      Acylneuraminic acid mixtures obtained from serum and saliva contain mainly N
      acetylneuraminic acid and N-acetyl-9-O-L-lactoylneuraminic acid, whereas small
      amounts of N,9-O-diacetylneuraminic acid are also present. No free N,O
      diacylneuraminic acids could be detected in the urine samples. None of the
      investigated fluids contained N-glycoloylneuraminic acid. The unsaturated N
      acetyl-2,3-dehydro-2-deoxyneuraminic acid is usually a component of the free
      acylneuraminic acid fractions of serum, saliva and urine. The body fluids of a
      patient with sialuria contain the same O-acylated and unsaturated N-acetyl
      neuraminic acid derivatives as mentioned above, but the total amounts of free
      acylneuraminic acids in these materials are significantly higher than found for
      normal persons.

PMID- 1017797
TI  - Studies on the kynurenine adminotransferase activity in rat liver and kidney.
AB  - The kynurenine aminotransferase activity of supernatant and mitochondrial
      fractions obtained from rat liver and kidney was studied with L-kynurenine and L
      3-hydroxykynurenine as substrates. A substrate inhibition with L-kynurenine at
      concentrations higher than 6-7mM was observed with all four enzyme preparations.
      This did not happen with L-3-hydroxykynurenine as a substrate. Moreover, the
      liver mitochondrial enzyme shows a Km for pyridoxal phosphate 2-4 times smaller
      than the other preparations when assayed with L-3-hydroxykynurenine as a
      substrate. Therefore, the accumulation of xanthurenic acid and not of kynurenic
      acid in B6 deficiency could be related both to this high activity of liver
      mitochondrial kynurenine aminotransferase with L-3-hydroxykynurenine, even at
      small concentrations of B6, and to substrate inhibition observed with L
      kynurenine and not with L-3-hydroxykynurenine.

PMID- 1017798
TI  - Haemocyanins in spiders, III. Chemical and physical properties of the proteins in
      Dugesiella and Cupiennius blood.
AB  - The haemolymph of the tarantulas, Dugesiella (Eurypelma) californica and
      Dugesiella (Eurypelma) helluo contains high molecular weight haemocyanin (80-82%
      of total blood proteins) and a second protein not related to haemocyanin (18
      20%). In the Lycosid spider, Cupiennius salei, haemocyanin (75% of total blood
      protein) occurs in two states of association. The haemocyanins were isolated by
      ultracentrifugation, gel filtration, isoelectric focusing, or preparative gel
      electrophoresis. Their sedimentation constants are 36.7 S (both tarantulas), 23.4
      S and 15.9 S (Cupiennius). After alkaline dissociation, polypeptides sedimenting
      at 5.8 S (D. californica) and 4.7 S (Cupiennius) were obtained. The molecular
      weight of the intact functional subunit is (by sedimentation equilibrium) 70 300
      (D. californica) and 69 900 (Cupiennius). Copper analysis results in closely
      similar values. By sodium dodecylsulphate gel electrophoresis, molecular weights
      of 71 000 (D. californica), 72 000 (Cupiennius) and 74 000 (D. helluo) were
      obtained. Denaturation with various agents did not lead to smaller polypeptides.
      The amino acid composition of the haemocyanins was determined (Table 1). The
      amino end group is blocked. The haemocyanins contain 1.2-1.5% of neutral
      carbohydrates and 0.3-0.5% of glucosamine (possibly acetylated). The neutral
      carbohydrates were identified with glucose, mannose, fucose, and arabinose,
      glucose being the dominant species. Neuraminic acid was not detected. The
      haemocyanins of the three species cannot be distinguished by their carbohydrate
      moieties, while there is a significant difference in amino acid composition
      between tarantula and Cupiennius haemocyanins. The second, non-respiratory
      protein isolated from spider blood sediments with 16.1 S (Dugesiella) or 15.9 S
      (Cupiennius). Its isoelectric point is at pH 5.5 It is stable in weakly alkaline
      solutions but can be denatured to yield polypeptide chains with molecular weights
      of 95 000 and 110 000. The amino acid composition is reported. As in the
      haemocyanins, the N-terminus is blocked. The carbohydrate content is 0.9%,
      glucose being the only sugar identified.

PMID- 1017799
TI  - Hydrophobic agaroses: basis for a model of multivalent effector-receptor
      interactions.
AB  - An increase in the density of butyl residues bound to Sepharose 4B leads to an
      enhancement of the affinity of these gels for phosphorylase b in the presence of
      1.1M ammonium sulfate. A Hill coefficient of 2.9 indicates that a minimum of ca.
      3 binding sites is involved in the positive cooperative adsorption of this
      enzyme. Binding studies of phosphorylase b on butyl-Sepharose of a specific
      degree of substitution demonstrate that the affinity of the gel for this ligand
      decreases as a function of fractional saturation. A Hill coefficient of 0.44
      indicates negative cooperativity as a result of multivalent binding. From these
      observations a multivalent, mobile receptor model is derived which can explain
      such characteristics of effector-receptor interactions as: positive and negative
      cooperativity, high binding constants and low dissociation rate constants. The
      application of this model to experiments taken from the literature on the binding
      of the multivalent effectors concanavalin A and cholera toxin to fat cells shows
      that the postulated mode of interactions is probably realized in nature.

PMID- 1017800
TI  - Snake venom toxins. The amino acid sequence of three toxins (CM-2e, CM-4a and CM
      ) from Naja haje annulifera (Egyptian cobra) venom.
AB  - Three toxins (CM-2e, CM-4a and CM-7) were purified from the venom of Naja haje
      annulifera by gel filtration on Sephadex and by ion-exchange chromatography on CM
      cellulose. They comprise 60 amino acid residues and are cross-linked by four
      intrachain disulphide bridges. The complete amino acid sequences of the three
      toxins have been elucidated. The toxicities, the serological properties, the
      sequences and the invariant amino acid residues of toxin CM-2e, CM-4a and CM-7
      resemble the corresponding properties of the cytotoxin group.

PMID- 1017801
TI  - Liver cell heterogeneity. The distribution of pyruvate kinase and
      phosphoenolpyruvate carboxykinase (GTP) in the liver lobule of fed and starved
      rats.
AB  - Pyruvate kinase and phosphoenolpyruvate carboxykinase activities were determined
      in microdissected freeze-dried liver cells from the periportal and pericentral
      area of the liver lobule. Pyruvate kinase activity was measured by a
      microfluorimetric procedure adapted to 20-200 ng tissue dry weight. In livers
      from fed rats, its activity was twice as high in the central zone as in the
      periportal cells; starvation reduced this gradient by decreasing central
      activities. Phosphoenolpyruvate carboxykinase activity was measured by a
      microradiochemical technique in 100-300 ng tissue dry weight. In livers from fed
      rats, this enzyme was nearly 3 times more active in the periportal cells than in
      the central area. Starvation increased this enzyme in both zones with a more
      pronounced change in the central cells. The results indicate a heterogeneous
      distribution of enzymes of carbohydrate metabolism in the liver lobule.
      Gluconegenesis seems to be localized preferentially in periportal hepatocytes,
      whereas the glycolytic enzyme was found to be more active in cells surrounding
      the pericentral liver cells.

PMID- 1017802
TI  - [The sequence of a dimetric hemoglobin (component IIbeta, Chironomus thummi
      thummi, Diptera) (author's transl)].
AB  - The primary structure of the dimeric hemoglobin CTT 11beta from the insect larva
      Chironomus thummi thummi (Diptera) is given. The sequence of a dimeric hemoglobin
      is presented for the first time. Some details of this primary structure are
      discussed and compared with human alpha-chains. The sequence was determined
      automatically.

PMID- 1017803
TI  - Effects of estrone, estradiol and estriol combined with dihydrotestosterone on
      mounting and lordosis behavior in castrated male rats.

PMID- 1017804
TI  - Androgen dependence of a marking pheromone in rat urine.

PMID- 1017805
TI  - The effects of the antiestrogen CI-628 on sexual behavior activated by androgen
      or estrogen in quail.

PMID- 1017806
TI  - Hormonal control of scent marking in the Indian musk shrew, Suncus murinus
      viridescens (Blyth).

PMID- 1017807
TI  - Effects of septal lesions on the courtship behavior of male ring doves
      (Streptopelia risoria).

PMID- 1017808
TI  - Hormonal control of male courtship behavior and female attractivity in the garter
      snake (Thamnophis sirtalis sirtalis).

PMID- 1017809
TI  - Adrenal disruption of maternal behavior in the caesarean-sectioned rat.

PMID- 1017810
TI  - Effects of ventromedial nucleus lesions on estradiol induced ovulation in the
      rat.

PMID- 1017811
TI  - Hypohaptoglobinemia in rural and urban populations of Bahia state, Brazil.

PMID- 1017812
TI  - Sesamoid bones of the hand: relationships to growth, skeletal and sexual
      development in girls.

PMID- 1017813
TI  - Relationships between body size and second metacarpal dimensions in Oaxaca
      (Mexico) school children 6 to 14 years of age.

PMID- 1017814
TI  - The relationship between growth in infancy and growth in adolescence: report of a
      longitudinal study among urban black adolescents.

PMID- 1017815
TI  - Total finger ridge-count and the polygenic hypothesis: a critique.

PMID- 1017816
TI  - Paternal age in relation to selected birth defects.

PMID- 1017817
TI  - Rural and urban Seminole Indian fertility.

PMID- 1017818
TI  - The correlations between anthropobiological and climatic variables in sub-Saharan
      Africa: revised estimates.

PMID- 1017819
TI  - Association between PTC taster status and goitre in a Papua New Guinea
      population.

PMID- 1017820
TI  - Relationship between reproductive fitness and anthropometric dimensions in a
      Mexican population.

PMID- 1017821
TI  - Pediatric overview [editiorial].

PMID- 1017822
TI  - Drug prescribing for the elderly.

PMID- 1017823
TI  - The geriatric patient.

PMID- 1017824
TI  - In Japan: health care for all and a 'demographic miracle'.

PMID- 1017825
TI  - The case of the retained antrum.

PMID- 1017826
TI  - Embryogenesis of argentaffin cells.

PMID- 1017827
TI  - CPK isoenzymes in evaluation of myocardial ischemic injury.
AB  - Enzymatic criteria for diagnosis of myocardial infarction have suffered from a
      lack of specificity, since enzyme elevations also occur in noncardiac disorders.
      The MB isoenzyme of creatine phosphokinase has provided a way out of this
      difficulty. Not only is it specific to injured myocardium but a recently
      developed plasma assay makes possible both diagnosis and, in many cases,
      measurement of the extent of damage.

PMID- 1017828
TI  - Reconstruction ('undiversion') of the diverted urinary tract.
AB  - Two operations to permit urinary drainage had been performed in a 2 1/2-year-old
      boy born with obstructing urethral valves, but infections and other compications
      were a constant threat, especially since the child had only one functioning
      kidney. After the anomalous valves were ablated endoscopically, the urinary tract
      was reconstructed, as shown here, to "undivert" the previously fashioned ileal
      loop bypass.

PMID- 1017829
TI  - Our "amber waves of grain".

PMID- 1017830
TI  - Dietary fiber and diverticular disease.
AB  - Can the regular consumption of bran and other fibrous foods help in preventing
      diseases of the colon? Indirect evidence supports the idea, although much remains
      to be learned. It seems probable that bulkier feces could increase the diameter
      of the colon and prevent sudden sharp rises in pressure that are believed to be
      responsible for the formation of diverticula. For most people, fiber is probably
      harmless and it may do some good.

PMID- 1017831
TI  - The case of the bubbly pancreas.

PMID- 1017832
TI  - The six million dollar man.

PMID- 1017833
TI  - Partial hepatectomy for metastatic carcinoma.
AB  - Three years after colonic resection for a rectal carcinoma, the patient evinced
      some weight loss and alkaline phosphatase elevation. Detailed workup revealed
      what appeared to be a solitary, well-defined metastatic lesion of the right
      hepatic lobe. Since the patient could be considered a good candidate for surgery,
      and given the grim prognosis of alternative approaches, hepatic lobectomy was
      carried out, as described here.

PMID- 1017834
TI  - GI problems in children: II.
AB  - Accurate differentiation of such disorders as intrahepatic and extrahepatic
      cholestasis and the two types of megacolon must precede attempts at treatment.
      Gastroesophageal reflux, viral hepatitis, and Reye's syndrome are also discussed.

PMID- 1017835
TI  - The krypton thunderbolt.

PMID- 1017836
TI  - Blood glucose: how reliable an indicator of brain glucose?
AB  - It is usually assumed that the concentration of glucose in the brain reflects
      that in the blood, so that measuring the latter provides an accurate index of the
      former. However, in two experimental situations analogous to anoxia and
      salicylate poisoning, brain glucose was found to be dangerously low in the
      presence of normal or even elevated blood glucose levels, and in these
      experiments administering glucose prolonged survival.

PMID- 1017837
TI  - Training black physicians: the current status.

PMID- 1017838
TI  - Health care in Caracas and Lima--oil makes difference..

PMID- 1017839
TI  - The case of the cardiophrenic mass.

PMID- 1017840
TI  - Whose energy?

PMID- 1017841
TI  - Termination of atrial fibrillation.

PMID- 1017842
TI  - Middle ear disease in children.

PMID- 1017843
TI  - Priorities governing the care of the critically ill.

PMID- 1017844
TI  - Disorders of the aging GI system.

PMID- 1017845
TI  - A cytotoxic substance in insect cell culture spent media.
AB  - Spent media from five different insect cell lines when inoculated into
      Trichoplusia ni (TN-368) cultures produced cytotoxicity resulting in rounding and
      detachment of cells. The substance in spent medium from the established cellline
      Carpocapsa pomonella (CP-169) is believed to be a toxin, based on the failure to
      serially passage the agent, the early appearance of the cytotoxic effect, and the
      inability to detect microbes by culturing techniques as well as by electron
      microscopy. The ability to extract the toxic substance from CP-169 cells
      indicates that it is cell associated. Biophysical and biochemical properties of
      the CP-169 cytotoxin are presented.

PMID- 1017846
TI  - [Problems of amoebiasis (author's transl)].
AB  - The problem by the amoebiasis is to differenciate the symptoms against the other
      similar diseases of the gastro-intestinal tract, also in cases of amoebic
      abscesses in liver, lungs, brain and other organs. The presence of zystes and
      minutaforms of E. histolytica in the stool is not to identify with amoebic
      dysenterie. Dysenterie in the tropics can have many different reasons and not
      alone amoebic infection. Persons with amoebic-infection are under the hygienic
      condition of central-europe not a risk for their surrounding persons and not like
      persons who excrete salmonelles. For the diagnostic the restoscopical picture and
      the X-ray of the colon are very important. To clear the diagnosis amoebic
      liverabscess serological tests, , immunelectrophoresis and immundiffusion are
      necessary, especially szintigraphic or sonographic examination; For therapie of
      amoebiasis we have to-day very good drugs. Even the liver abscess early diagnosed
      is possible to cure.

PMID- 1017847
TI  - [Treatment of schistosomiasis haematobium with metritionate in OPD-patients
      (author's transl)].
AB  - 40 patients--5 to 50 years of age--voiding eggs of Schistosoma haematobium in
      their urine--underwent treatment with Metrifonate at the OPD of Bong Mine
      Hospital, Liberia. The patients received 10 mg/kg body weight 3 times at a
      fortnight's interval. The drug was swallowed under medical supervision. 27
      patients no longer passed eggs after the 1. dose of Metrifonate, 37 no longer
      voided eggs after the 2. administration. 1 patient did not show up for control
      after the 3. dose. Theoretically he may not be healed. 1 other patient who came
      for control after 12 months had been exposed to reinfection and again voided eggs
      in her urine. She had been negative after the 2. treatment. Reinfection may have
      happened. Patients could be controlled over a period of 6-14 months. Thus,
      Metrifonate seems to be an effective drug in the treatment of urinary
      schistosomiasis. Side-effects (nausea, abdominal pains, and--very rare--vomiting)
      were mild and disappeared spontaneously within less than 24 hours after
      medication. Patients did not have to interrupt school, daily activities, and
      treatment. Statistically, Metrifonate did not show any influence on transaminase
      SGOT, SGPT, and LDH during and after the course of treatment. The same evaluation
      applies to eosinophilia. There is no increase or decrease of this particular type
      of cell during and after treatment 7 patients showed alterations of their ECG
      curves. There were changes of the T-wave in V1-4. In adults traces were normal
      again several months after completion of treatment. It seems to be difficult to
      interpret ECGs in West African youngsters. X-ray photos of the lungs never
      revealed any pathological findings which could be connected to the course of
      treatment. Metrifonate seems to be a valuable drug in treatment of Schistosoma
      haematobium-infection. The drug is well tolerated if the treatment scheme-
      mentioned above--is used.

PMID- 1017848
TI  - [Fatal diphtheria in a 26-year-old man. Repetitorium; Known and current aspects
      of diphtheria].
AB  - This paper reports on a 26 year old male who died of toxic diphtheria with all
      typical features such as: Bullneck, paralysis of the soft palate, renal failure
      accompanied by proteinuria and--most notably--myocarditis (very typical
      microscopically) with circulatory disturbances and finally left and right hand
      failure. The myocarditis hat caused increases of SGOT, SGPT, CPK, LDH and HBDH to
      values not seen before by us in the course of myocarditis. The patient had been
      immunized against diphtheria as a child. Initial treatment consisted of the
      application of ampicillin which caused rapid regression of the local symptoms in
      the pharyngeal region including the bullneck-symptom; of course the course of
      intoxication was not influenced, even after the patient had been admitted to the
      hospital, the disease correctly diagnosed and antitoxin given three days before
      death.

PMID- 1017849
TI  - [Assessment of the efficiency of vaccination against influenza (author's
      transl)].
AB  - The efficiency of the vaccination against influenza resp. its assessment depends
      on methodological factors, on the vaccine in use and on the epidemiological
      situation. According to serological tests protection rates (p) may be found of
      0,8-0,9; a combined clinical and serological evaluation leads to a value of p=0,7
      and after clinical estimation p=0,5. For statistical evaluation it is important
      to know whether the groups of persons to be compared were randomized or selected.
      Vaccination groups consisting of volunteers were selected in as much as the
      vaccines apparently exhibited a higher premorbidity than the control groups.
      Further on the protection rate is influenced by the number of vaccinations
      performed. Another very important factor is the composition of the vaccine in
      use, which should be in accordance with the recommendations of the WHO.
      Concentration of antigen and addition of adiuvant also influences the efficiency
      of inactivated vaccines. The antigenic composition is also relevant in live
      attenuated vaccines. Epidemiological factors are of importance in as much as the
      efficiency of the vaccination rises with the morbidity of the population.
      However, even in interepidemic periods the vaccination offers a certain degree of
      clinically observable protection (0,3). The indication for vaccination against
      influenza is influenced by age. In older persons the vaccination depresses
      morbidity and mortality rates, in middle aged working people lower morbidity and
      a drop in days of absence resulted as consequence of a vaccination campaign,
      whereas in children shedding of virus is prevented by the vaccination.

PMID- 1017850
TI  - [Lysosomal proteinasen and peptidasen in serum of children with inflammatory
      diseases (author's transl)].
AB  - In the serum of 43 children the activities of proteinases and peptidases by mean
      of 41 substrates have been determined in order to get knowledge of overall
      activities and differentiation of lysosomal proteolytic enzymes. Proteinases,
      cathepsins A, B, C and D, aminopeptidases, carboxypeptidases, dipeptidases,
      tripeptidases and aminoacidarylamidases have been checked. The enzyme pattern of
      the serum of a collective of 15 healthy children or those without serious
      clinical signs is demonstrated, also the alterations and differentiations in the
      serum of children with leucemia, pneumonia, inflammatory diseases of the
      respiratory tract, other inflammatory diseases and common diseases. Leucyl-glycyl
      glycyltripeptidase, glycyl-glycyl-glycyltripeptidase, a proteosterase,
      carboxypeptidase A, a neutrale proteinase and basic proteinase (cathepsin B) and
      cathepsin C are increased. A distinct elevation has been found only in children
      with leucemia and pneumonia.

PMID- 1017851
TI  - Isolation and physico-chemical characterization of bovine serum and colostral
      immunoglobulin G (IgG) subclasses--a comment.

PMID- 1017852
TI  - Laser light scattering spectroscopic immunoassay for mouse IgA.

PMID- 1017853
TI  - Laser light scattering spectroscopic immunoassay in the agglutination-inhibition
      mode for human chorionic gonadotropin (hCG) and human luteinizing hormone (hLH).

PMID- 1017854
TI  - A study on cell mediated immunity to rabies virus: lymphocyte-mediated
      cytotoxicity in vitro.

PMID- 1017855
TI  - Extraction of vaccinia virus and purification of vaccinia elementary body
      suspension with Mafron 11.

PMID- 1017856
TI  - Antibiotic sensitivity pattern of V. cholerae strains isolated in 1974.

PMID- 1017857
TI  - Bacteriological study of group D streptococci.

PMID- 1017858
TI  - Classification of subjects as slow or rapid inactivators of isoniazid based on
      the ratio of acetylisoniazid to isoniazid in urine determined by a simple
      colorimetric method.

PMID- 1017859
TI  - Clinical and biochemical evaluation of low protein diet in chronic renal failure
      in India.

PMID- 1017860
TI  - Babies with severe intra-uterine growth retardation-linear physical growth from 0
      24 months.

PMID- 1017861
TI  - G-6-PD, PK, GSH levels and GSH stability in some haematological disorders.

PMID- 1017862
TI  - Alteration in the ABH blood group antigens during pregnancy--a preliminary
      communication.

PMID- 1017863
TI  - The effect of Bengal gram on acid mucopolysaccharide content of aorta in
      experimental atherosclerosis.

PMID- 1017864
TI  - Onion and garlic in experimental cholesterol induced atherosclerosis.

PMID- 1017865
TI  - Cirrhosis of the liver in rabbits induced by a high cholesterol diet--an
      experimental model.

PMID- 1017866
TI  - Dosimetry in radioisotope placentography.

PMID- 1017867
TI  - Polyethylene glycol in radioimmunoassay of TSH.

PMID- 1017868
TI  - Chromosomal and DNA analysis of human lymphoma cases.

PMID- 1017869
TI  - Small intestinal functions in diabetes mellitus.

PMID- 1017870
TI  - Suicidal attempt or accident.

PMID- 1017871
TI  - Hodgkin's disease-histopathological study of 85 cases.

PMID- 1017872
TI  - Peritoneal and haemodialysis in children.

PMID- 1017873
TI  - Initial manifestations of septicaemia mimiking rheumatism in children.

PMID- 1017874
TI  - A clinico-bacteriological study of meningitis in infancy and childhood.

PMID- 1017875
TI  - Volvulus of the small bowel due to ascaris.

PMID- 1017876
TI  - Hydrocephalus due to prenatal infection with the lymphocytic choriomeningitis
      virus.
AB  - The results are presented of serological examinations in a total of 4235 subjects
      including blood donors (341 persons), pregnant women (1784), newborns (833),
      patients with malignant tumours (248), patients with influenza-like diseases
      (548), patients with abacterial meningitis (295), infants under one year with
      hydrocephalus (40), infants under two years with other nervous system diseases
      (110), mothers of seropositive children with hydrocephalus (12) and mothers of
      seronegative children with hydrocephalus (24). The investigations revealed 16
      cases of serologically confirmed prenatal lymphocytic choriomeningitis virus
      infection. Immunofluorescent antibody to this virus was detected in the children
      in most cases at high titers and in their mothers at moderate and low titers. In
      14 children hydrocephalus was manifest, one child was suffering from infantile
      cerebral palsy, and one child from congenital right side blepharoptosis. Foci of
      chorioretinal degeneration were found in 14 patients. During pregnancy six
      mothers had an influenza-like illness; the other ten mothers denied any disease
      associated with fever.

PMID- 1017877
TI  - Concentrations of cefazolin in human skeletal muscle.
AB  - Tissue concentrations of cefazolin were measured in 18 patients undergoing
      urological operations. Specimens of skeletal muscle and blood were taken
      simultaneously at predetermined intervals. The concentrations in serum and
      homogenized skeletal muscle were determined by means of the agar well diffusion
      method. A comparison of standard curves obtained with phosphate buffer solution
      and the supernatant of muscle homogenate revealed no substantial binding of
      cefazolin to the supernatant of muscle homogenate. Because of methodological
      difficulties in determining the different compartments of a tissue specimen
      concentrations in tissue were not corrected. Within two hours after a short
      infusion (25 min.) of 2 g of Cefazolin in muscle tissue a peak concentration of
      20 mug/g was reached. A tissue level above 10 mug/g maintained for three hours.
      This concentration is high enough to inhibit nearly all strains of E. coli,
      Klebsiella, Salmonella, Shigella and a large part of Proteus mirabilis, whereas
      nearly all gram-positive bacteria are inhibited at a lower concentration.

PMID- 1017878
TI  - Viridans streptococci associated with periapical dental abscesses.
AB  - Viridans streptococci isolated in apparently pure culture from periapical dental
      abscess have been examined. It has been found that each abscesses is associated
      with only one type of a given species of Streptococcus. The distribution of types
      of Strep. mitis found in abscesses differed from the distribution in healthy
      mouths, but no particular type occurred significantly more often in abscesses
      than in mouths.

PMID- 1017879
TI  - [The patient as a source of bacteria in intensive care units: influence of
      antibiotics and tracheal intubation (author's transl)].
AB  - 133 patients in an intensive care unit, who prior to admission had not shown any
      signs of bacterial infection and had not received antibiotic treatment, were
      assigned to two groups at random. One group received antibiotic prophylaxis with
      penicillins or cephalosporins (+Pat.), the other group did not receive
      antibiotics (-Pat.). Staph. aureus was the most frequent facultative pathogen in
      tracheal secretions and in the environment of "-Pat.". This organism was
      significantly more frequent in "-Pat." than in "+Pat." in both the tracheal
      secretions and the environment. Klebsiella spp. outnumbered all other species in
      "+Pat.". They were significantly more frequent in tracheal secretions of "+Pat."
      than of "-Pat.". In the first week of hospitalisation marked changes were seen in
      bacterial flora of tracheal secretions of "+Pat.". Colonization with
      grammnegative bacteria rose to nearly 100%, the frequency of Staph. aureus
      diminishing at the same time. Monitoring by contact cultures revealed that
      gramnegative rods were significantly more numerous in the environment of "+Pat."
      than of "-Pat.". Matching bacterial strains cultured from tracheal secretions and
      from the environment of the patients proved that "+Pat. spread significantly
      higher numbers of their gramnegative bacteria into the environment. The same is
      true of "-Pat." for Staph. aureus. Intubation had no noticeable effect on the
      degree of contamination of the surroundings with Staph. aureus. Gramnegative rods
      were significantly more frequent in tracheal secretions of patients with
      intubation than in patients without. The same trend was observed for
      environmental contamination. As the clinical results of this study have shown,
      antibiotic prophylaxis does not protect patients from infections to the extent
      expected. Patients, and particularly intubated patients, receiving antibiotic
      treatment have to be considered as sources of highly resistant gramnegative
      organisms.

PMID- 1017880
TI  - Ototoxicity and nephrotoxicity of netilmicin.
AB  - Comparative functional and histological tests were performed in eight groups of
      ten quinea pigs each, which were administered 50, 75, 100 and 150 mg of
      netilmicin respecitvely b.i.d. for 29 days, 15 and 25 mg of gentamicin and 50 and
      100 mg of amikacin per kg body weight respecitvely b.i.d. and in one control
      group of ten animals. The tests showed a low degree of ototoxicity and
      nephrotoxicity of netilmicin.

PMID- 1017881
TI  - [The nitroblue tetrazolium test in the diagnosis of purulent meningitis (author's
      transl)].
AB  - The nitroblue tetrazolium (NBT) reduction test was performed in 26 children
      suffering from purulent meningitis using the technique of Gifford and Malawista
      modified by Kim et al. 53.,% of the children showed a relative and absolute
      elevation in the nelative NBT-value only, 15.4% had an absolute elevation of the
      formazan cell count only, and 19.2% showed values within the normal range. While
      the elevation of the relative NBT-value is important for diagnosis, results
      showing normal absolute and relative NBT-values or elevate absolute NBT-values
      only should not be used for establishing the diagnosis of bacterial infection. In
      such cases the negative result may demonstrate a neutrophil dysfunction state
      during severe systemic illness.

PMID- 1017882
TI  - [The problem of resistance to antibiotics: a focal point of research in molecular
      genetics (author's transl)].
AB  - The molecular basis of bacterial resistance to antibiotics is discussed as an
      example of one of the focal points of research in bacterial genetics. The
      practical implications of research in this field are pointed out, and measures
      for curbing antibiotic resistance are suggested.

PMID- 1017883
TI  - [Clinical study of septicaemia (author's transl)].
AB  - The internationally accepted term septicaemia is used to describe illnesses in
      which pathogenic microorganisms are present in the blood. Septicaemia should be
      defined according to the causative organism, the portal of entry and the
      underlying disease. In the last 16 years the causative organisms in 788 cases of
      septicaemia in our hospital were found to be gram-positive cocci in 28.1% gram
      negative rods in 37.6%, and other organisms in 24.i%. Infections with Psuedomonas
      in particular have become more frequent in recent years. The range of causative
      organisms in septicaemia varies considerably with the patient groups involved.
      Thus patients with myeloid insufficiency contracted primarily gram-negative
      septicaemia. As in the past, the pathogens in endocarditis today are primarily
      streptococci. In hemodialysis staphylococci and gram-negative rods are shown to
      occur with equal frequency. The most important clinical manifestation of
      septicaemia is fever with rigor. The poor prognosis in gram-negative septicaemia
      is mainly due to the onset of septic shock. Skin colonisation is often a typical
      sign of septicaemia and can also sometimes serve as a diagnostic indication.
      Hemorrhagic pustules surrounded by a zone of inflammation are typical in
      septicaemia caused by meningococci or gonococci. Skin eruptions are rare in
      septicaemia caused by streptococci of staphylococci. Whereas skin eruptions are
      absent in septicaemia due to enterobacteria, they are very often present in
      septicaemia caused by Pseudomonas. In bacterial endocarditis a wide variety of
      skin lesions can occur.

PMID- 1017885
TI  - Dextran-induced anaphylactoid reactions in man: role of dextran reactive
      antibodies.
AB  - Dextran reactive antibodies (DRA) were studied in 123 patients having experienced
      dextran-induced anaphylactoid reactions (DIAR) during 1970-1975. No evidence for
      reaginic DRA was obtained by radioallergosorbent technique and passive cutaneous
      anaphylaxis in Cynomolgus monkeys; total IgE levels were within normal range. It
      is concluded that DIAR are not mediated by dextran-specific reagins. Further, no
      reaginic antibodies against potential contaminants from the dextran manufacturing
      process were demonstrable. In two population samples of normal human sera from
      Sweden and Germany hemagglutinating DRA (IgG, IgA, and IgM classes) were found in
      63 and 74%, high titres (16-256) comprising 14 and 25%. In dextran reactors a
      direct positive correlation between titres of hemagglutinating DRA and increasing
      severity of DIAR was observed. The accumulation of high DRA titres in severe
      reactions may be taken as circumstantial evidence for the causal role of
      hemagglutinating DRA in these cases. However, if high titres of DRA alone were
      responsible for triggering DIAR, the expected frequency would be more than
      thousand times higher than the reported global incidence of DIAR. To explain this
      discrepancy, involvement of certain Ig classes or subgroups, possibly in
      combination with other predisposing factors is suggested. In mild reactions DRA
      appear to play a negligible role. Positive dextran wheal and flare reactions,
      often correlated with high titres of hemagglutinating DRA, were seen in 32% of
      dextran reactors, indicating that skin tests are of limited predictive value. No
      significant difference between sexes, age groups, or pre- and intraoperatively
      started dextran infusions was observed; association with certain diseases was not
      apparent.

PMID- 1017884
TI  - [Ototoxicity of the aminoglycoside antibiotics (author's transl)].
AB  - A report is given on advances in our knowledge of the ototoxicity of
      aminoglycoside antibiotics. The pharmacokinetics of gentamicin, tobramycin,
      sisomicin and amikacin in the inner ear, cerebrospinal fluid, compartments of the
      eye and serum were determined by means of pharmacokinetical investigations. The
      influence of long-term treatment, and the effects of otitis media and uremia were
      also studied. Furthermore, the influence of therapeutic methods on ototoxic
      damage was investigated, and the ototoxicity of these antibiotics was compared.
      The experiments were performed in guinea pigs, concentrations of the antibiotics
      being measured by a microbiological method and confirmed by investigations with
      C14 labeled gentamicin. The hair cell degeneration pattern after administration
      of the new aminoglycosides was determined using surface preparations. The
      prophylactic effect upon ototoxicity of the administration of dimercaptopropanol
      or of dividing up the daily dosage was examined. Studies were made of ototoxicity
      in children, and in patients with otitis media or renal impairment, and the
      effect of simultaneous ethacrynic acid or noise was assessed. The problem of
      delayed and progressive ototoxicity, and the reversibility of ototoxic damage
      caused by these antibiotics was examined histologically, and the ototoxicity of
      gentamacin, tobramycin, sisomicin and amikacin was compared. The influence of the
      new aminoglycoside antibiotics upon the amount of acidic and alkaline phosphatase
      and unspecific esterases in the inner ear was studied. The clinical importance of
      the latest experimental findings is emphasised. The clinical picture of ototoxic
      damage after administration of the new aminoglycoside antibiotics shows no
      special characteristics. The ototoxicity of these antibiotics after topical use
      is mentioned. Attention is drawn to guidelines for the prevention of ototoxic
      damage by aminoglycosides.

PMID- 1017886
TI  - Effect of catecholamines and sympatholytics on survival and circulatory
      parameters in protracted anaphylactic shock of guinea pigs.
AB  - Protracted anaphylactic shock of guinea pigs led to death in over 90% of the
      animals, and good protection was obtained with an infusion of adrenaline after
      dibenamine pretreatment. Adrenaline alone, in doses which prevented the
      anaphylactic fall of arterial blood pressure, had no beneficial effect. Practolol
      abolished the therapeutic action of the combination of dibenamine/adrenaline.
      Stimulation of beta-receptors by isoproterenol did not increase the survival
      rate. With dopamine, however, a significant prolongation of the survival times
      was obtained.

PMID- 1017887
TI  - The requirement of thymus competence for both humoral and cell-mediated steps in
      expulsion of Nippostorngylus brasiliensis from mice.
AB  - The worm damaging process (step 1 of Nippostrongylus brasiliensis expulsion from
      rodents) does not occur in congenitally thymus-deficient (nude) mice as
      determined by worm morphology, female worm fecundity, and kinetics of worm
      expulsion upon transfer into normal rats. Expulsion of damaged N. brasiliensis
      (step 2) does not occur subsequent to transfer of such worms from rats into nude
      mice. Morphological changes and reduced fecundity appeared in adult worms from
      normal thymus-bearing mice as early as the first day of patency (day 6 of
      infection). Thus, the worm damaging process is initiated several days earlier in
      mice than in rats and may, therefore, account for the reduced longevity of N.
      brasiliensis in mice compared with rats.

PMID- 1017888
TI  - Cryoprecipitates and immune complexes: differentiation between cold insoluble
      immune complexes and nonspecific cryoprecipitates.
AB  - Cold insoluble circulating immune complexes occurred in 77% of rabbits immunized
      with 125I BSA. 9.8% of the total cryoprotein was 125I BSA. This represented 43%
      of the serum antigen. Tripling the antigen concentration in vitro decreased the
      amount of cold insoluble antigen by as much as 83%. In nonspecific
      cryoprecipitates only 0.4% of the total cryoprotein was 125I BSA. This
      represented only 0.028% of the serum antigen. Tripling of the antigen
      concentration in vitro increased the amount of cold insoluble antigen. Cold
      insoluble circulating immune complexes occur at a critical antigen-antibody ratio
      and can be differentiated from nonspecific cryoprecipitates.

PMID- 1017889
TI  - Effect of alterations in metabolic rate on the duration of tolerance in
      neonatally injected animals.
AB  - Exposure to low environmental temperature caused a decrease in the half-life of
      human albumin (HA) in rabbits injected with 20 mg HA at birth, and a twofold
      increase in the proportion of animals which lost their tolerance by 150 days of
      age. Administration of thyroxin produced an even greater effect with respect to
      tolerance loss. Simlar mechanisms may be involved in the effects of cold exposure
      and thyroxin administration on tolerance duration. One possible mecahnism is that
      the duration of tolerance is dependent upon the metabolic half-life of the
      tolerance-inducing antigen. An alternative mechanism could be a cold- or thyroxin
      induced enhancement of the recruitment of immunologically competent cells from an
      undifferentiated population of stem cells.

PMID- 1017890
TI  - Studies on passive transfer of anti-dextran and anti-egg albumin reactivity in
      the rat.
AB  - We were unable, passively, to transfer reactivity against dextran to the skin or
      peritoneal mast cells of non-dextran-reactive rats, by using serum or material
      eluted at pH 3 from mast cells of spontaneously dextran-reactive rats. When the
      dextran-reactive donor rats had also been immunized against egg albumin (EA) with
      pertussis vaccine (inducing IgE anti-EA antibody), passive sensitivity against EA
      (but not against dextran) could easily be transferred. The results indicated that
      the anti-dextran reactivity is not due to IgE antibody. Systemic reactions
      against dextran and EA differed in pattern, supporting the concept that the two
      substances acted through different mechanisms.

PMID- 1017891
TI  - IgE production in five inbred rat strains following immunization with alum
      precipitated egg albumin.
AB  - Five inbred rat strains were assessed for their ability to mount IgE responses to
      alum-precipitated egg albumin (alum EA). Fischer (FI) and Lewis (LE) rats which
      possess the B1 at the major histocompatibility (Ag-G) locus exhibited weak IgE
      responses to this antigen. High titer IgE responses were obtained in rats
      possessing the B3 allele at the Ag-B locus. In some instances the anti-EA IgE
      response was enhanced following an infection with Nippostrongylus brasiliensis.
      An effort was also made in these studies to determine whether or not there is
      some correlation between high IgE production and a depressed capacity for
      cellular immunity. The basis of these experiments was twofold: (a) recent reports
      have shown elevated serum levels of IgE in some clinical diseases where cellular
      immunity is depressed, and (b) in the studies reported here, high titers of IgE
      were obtained in one rat strain known to be somewhat deficient in its capacity
      for cellular immunity, whereas very low titers were produced by a strain which is
      much stronger in this respect. From the results obtained, there appears to be no
      correlation between IgE production and an inherently weaker capacity for cellular
      immunity.

PMID- 1017892
TI  - Adenylate cyclase activity in heart and lung: effect of epinephrine and histamine
      in control and sensitized guinea pigs.
AB  - The effect of epinephrine and histamine on adenylate cyclase activity in lungs
      and hearts of control and ovalbumin-sensitized guinea pigs was investigated.
      Epinephrine at 10(-6) M concentration stimulated adenylate cyclase from both
      organs of the sensitized animals but had no effect on the enzyme from control
      tissues. At 10(-4) M, epinephrine stimulated equally the enzyme activity from the
      control and sensitized lungs and hearts. Histamine, 10(-6) and 10(-4), stimulated
      equally adenylate cyclase in tissues from both groups of animals. The results
      suggest that ovalbumin sensitization leads to hypersensitivity of the beta
      adrenergic receptors to epinephrine without changing their sensitivity to
      histamine.

PMID- 1017893
TI  - Diagnosis of reaginic allergy with house dust, animal dander and pollen allergens
      in adult patients. I. A comparison between RAST, skin tests and provocation
      tests.
AB  - RAST analyses were performed with house dust, animal dander and eleven pollen
      allergens in 410 adult patients with asthma and/or rhinitis and the findings were
      compared with skin test and provocation test results. The overall correlation
      between 1,316 provocation tests and RAST was 78% and the correlation between
      1,778 skin tests and RAST was 66%. The relationships between RAST and in vivo
      tests differed considerably from allergen to allergen. No significant differences
      were found between various age groups. According to the in vivo tests the RAST
      showed more often positive results in patients with pronounced allergy than in
      patients with low-grade allergy. Higher RAST classes were most often combined
      with positive in vivo tests. It is concluded that in cases with RAST classes 2-4,
      a reasonably well-established allergy diagnosis can be reached without the
      inclusion of additional in vivo tests. In other cases, however, application of
      further diagnostic methods is required.

PMID- 1017894
TI  - Immunoglobulins in nasal secretion with special reference to IgE. I.
      Methodological studies.
AB  - Different ways of collecting relatively large volumes of nasal secretion with as
      physiological a composition as possible were studied. Nasal secretion was
      collected by the so-called nasal spray washing method from 5 patients with
      allergic rhinitis due to pollen and 5 healthy persons during a pollen-free
      season. The collection was performed without any provocation and following nasal
      provocation with histamine or allergen solution. With the radioimmunosorbent
      test, in which the lower limit of measurement was 0.1 units/ml, IgE could be
      quantified in 52 of 60 analysed secretions. IgA, IgG and albumin were
      demonstrated in all secretions. In the allergic patients, following histamine and
      allergen provocation, a relative increase in the concentration of IgE and albumin
      and a significant decrease of the IgA/albumin ratio in nasal secretion was found.
      In the healthy subjects, such changes in the secretion were observed only after
      histamine provocation. Calculations also suggested some local production of IgE,
      but not at all of the same order of magnitude as of IgA.

PMID- 1017895
TI  - Immunoglobulins in nasal secretion with special reference to IgE. II. Seasonal
      studies of Timothy-specific IgE-antibody in patients with allergic rhinitis.
AB  - 14 adult patients with allergic rhinitis due to timothy pollen were observed for
      13 weeks during the grass pollen season. IgE, IgA and timothy-specific IgE
      antibodies could be quantified in all serum and secretion samples. Total IgE and
      specific IgE antibodies in both serum and secretion reached significantly higher
      levels in samples taken during and after the pollen season than before the
      season. These seasonal changes proved to be significantly more pronounced in
      nasal secretion than in serum. An indication of local production in the nasal
      mucosa of IgE, IgA and secific IgE antibodies was also found.

PMID- 1017896
TI  - Anaphylactoid reactions in rats and the blood sugar level.
AB  - When the blood sugar level in rats is reduced by insulin, the carrageenan
      anaphylactoid reaction in one hindpaw is inhibited although the dextran
      anaphylactoid reaction in the other hindpaw of the same animals is potentiated.
      When the blood sugar level is raised after alloxan pretreatment, the carrageenan
      reaction is potentiated whereas the dextran reaction is inhibited. The results
      support the hypothesis that the two local irritants exert their effects by
      involving different mechanisms.

PMID- 1017897
TI  - In vitro activity of anti-DNA antibodies from SLE patients in antibody-dependent
      cell-mediated cytotoxicity.
AB  - Peripheral blood lymphoid cells from normal individuals were cytotoxic to target
      cells coated with DNA when incubated with serum from patients with systemic lupus
      erythematosus (SLE) but not when incubated with serum from normal subjects. Sera
      from SLE patients with clinically acitve disease were more active than sera
      obtained from those patients in remission. In the absence of normal lymphocytes,
      SLE sera were not cytotoxic to the DNA-coated cells. The active fraction in the
      serum appeared to be IgG anti-DNA antibodies. These studies indicate that anti
      DNA can operate through the antibody-dependent cell-mediated cytotoxicity
      mechanisms in vitro.

PMID- 1017898
TI  - Carrageenan and dextran in rats.
AB  - Carrageenan injected subcutaneously into one hindpaw of the rat produces an
      anaphylactoid reaction which prevents the same paw responding to a second dose 14
      days later but does not alter the response to dextran. However, dextran does not
      modify the response of the hindpaw to a subsequent dose of either dextran or
      carrageenan 14 days later. When using these models of inflammation for testing
      the anti-inflammatory activity of drugs, valuable extra information may be gained
      by adopting the cross-over technique and using both paws of each animal.

PMID- 1017899
TI  - Serologic languages and the A1-A2 blood groups.

PMID- 1017900
TI  - Factors in the tissue eosinophil responses in human immediate hypersensitivity
      reactions.
AB  - Factors underlying the eosinophil responses in the tissue sites of immediate
      hypersensitivity reactions have been investigated. A quantitative assessment of
      the number of eosinophils appearing in skin test reactions to ragweed antigen and
      compound 48/80 in ragweed-sensitive humans has been compared with several other
      parameters. There was a moderate, statistically significant, correlation with
      serum levels of IgE-class antiragweed antibody; also, eosinophil responses were
      minimal or absent in minimally positive threshold dilution skin tests. Tissue
      eosinophil responses were generally limited to those with baseline blood
      eosinophil levels of at least 150 mm3; however, there was no correlation between
      blood and tissue eosinophil levels in individual subjects. These findings suggest
      that the pathogenesis of the observed tissue eosinophil responses may be
      multifactorial.

PMID- 1017901
TI  - Preparation and stability of 131I-tetracycline.

PMID- 1017902
TI  - [Method for measurement of the effective left ventricular ejection fraction by
      coupling radiocardiography-cardiac-scintigraphy. Its interest for the
      determination of aortic and mitral regurgitations (author's transl)].

PMID- 1017903
TI  - From heroin to methadone-social role changes and reinforcement differentials in
      relation to outcome on methadone. Part II. The study of social role changes.
AB  - The life-styles of addicts who are Successful, Marginally Successful, and
      Failures in a methadone maintenance program are examined by in-depth interviews
      in five time periods-early family life, the preheroin period, late heroin,
      premethadone, and methadone maintenance. The hypothesis is confirmed that the
      more the methadone patient has managed to develop a new and more conventional set
      of peer group, familial, and occupational roles, the greater the likelihood of
      his success on methadone maintenance. The in-depth view of the groups over time
      suggests that the pattern of alternation of positive reinforcements and punishing
      situations may be associated with outcome.

PMID- 1017904
TI  - Behavioral competence training: a model of rehabilitation.
AB  - Approaches to the treatment and rehabilitation of drug abuse populations are
      examined. It is argued that a new model is needed which will more effectively
      assist in the task of rehabilitation than traditional psychiatric treatment or
      completely medically oriented programs. A Behavioral Competence Training Model is
      proposed, based on learning concepts of behavior and psychosocial definitions of
      adjustment. Its implications for assessment, therapeutic design, and research are
      discussed. It is concluded that despite possible limitations, the model has a
      definite place in the rehabilitative process, and may effectively be included in
      any multiform program serving a diverse population.

PMID- 1017905
TI  - The veridicality of addicts' self-reports in social research.
AB  - This report examines the accuracy or veridicality of information obtained through
      interviews with drug addicts. Comparisons were made between the self-reports on
      six items of the interview and official records of the Baltimore City Police
      Department, the Baltimore City Juvenile Court, and the Federal Bureau of
      Investigation. The findings provide no evidence of systematic distortion intended
      to "cover-up" the criminal side of addict life. While errors of recall probably
      do affect self-reports, the incomplete status of official records frequently used
      to validate self-reports should be of equal concern.

PMID- 1017906
TI  - Group embedded figures test performance as a predictor of cognitive impairment
      among alcoholics.
AB  - The present study investigated the sensitivity of the Group Embedded Figures Test
      (GEFT) as a predictor of cognitive impairment among alcoholics. The GEFT, Shipley
      Hartford, and Memory-for-Designs tests were administered to 90 male alcoholics.
      GEFT performance correlated significantly with measures of impairment even when
      the influence of age and education were controlled. Field-dependent Ss performed
      at a significantly more impaired level on measures of abstract reasoning,
      perceptual-motor function, and short-term visual-spatial memory when compared
      with intermediate and field independent Ss; no differences were found among
      groups on general verbal ability. The results suggest that the GEFT might
      profitably be included in screening batteries for impaired cognitive function.

PMID- 1017907
TI  - Drug dependence and self-esteem.
AB  - A number of recent studies have dealt with variables related to self-esteem, but
      despite suggestions in the literature, there are few empirical studies concerned
      with the association between self-esteem and drug dependence. In an investigation
      of self-esteem, 71 subjects completed semantic differential forms for their self
      and ideal-self concepts. Four hypotheses were investigated. It was predicted that
      differences in self-esteem (as measured by the discrepancy between self and ideal
      self concepts), would be found between inpatient and outpatient groups, males and
      females, intravenous and oral users, and between drug-dependent subjects and a
      control group. No differences were found between inpatients and outpatients, or
      between intravenous and oral groups. However, females who were dependent upon
      drugs were found to have lower self-esteem than males in terms of the evaluation
      factor. No such sex differences were found between all drug groups and the
      control group on the evaluation and potency factors. It is suggested that the
      results show considerable deficiencies of self-esteem among drug-dependent
      patients, and that female addicts are especially deficient in this respect. In
      terms of etiology, this association between drug dependence and low self-esteem
      may indicate that those individuals with a deficient self-image who are exposed
      to drugs may be at risk; this may carry implications also for alcohol and
      nicotine dependence. It is suggested that self-image therapy may be of value for
      certain drug-dependent patients, especially females.

PMID- 1017908
TI  - Nonmedical drug use by high school students: a three-year survey study.
AB  - The characteristics of high school student nonmedical drug users and nonusers
      were assessed by three successive yearly surveys. The surveys asked about
      respondents' personal, parent, and family characteristics; their behavior; their
      attitudes concerning themselves; their parents and family, adult society, and
      school. Drug use estimates for respondents' parents and peers, as well as
      themselves, were also assessed. Drug users were consistently different from
      nonusers in many areas. The incidence of drug increased in each of the three
      successive surveys, drug users tending to be older and male. With regard to
      behavior, drug users more frequently acted in a nonadult approved manner than
      nonusers. Drug users estimated their parents more likely to use alcohol and
      cigarettes, and estimated more peers to use nonmedical drugs than nonusers.
      Prediction of drug users from the data could be made with 80% and better
      accuracy. The findings are discussed in terms of their significance in
      understanding the nature of adolescent drug use.

PMID- 1017909
TI  - A follow-up study of dropouts from a methadone maintenance program.
AB  - This is a follow-up study of 112 dropouts from one of the largest methadone
      maintenance programs in New York City. It was found that 47% of the sample were
      on methadone at other programs at the time of the follow-up interviews, 26% were
      drug-free, 16% were using drugs, and 11% were in institutions. However, because
      of certain sample biases, inferences to the total population of dropouts were
      made through weighted estimates. A more accurate, although approximated,
      percentage distribution of the outcomes is that 20% of all dropouts were on
      methadone at other programs, 43% were drug-free, 23% were using heroin again, and
      14% were in institutions. Some of the implications of these findings are
      discussed.

PMID- 1017910
TI  - An application of stepwise discriminant analysis to the characterization of
      military heroin dependents, illicit drug users, and psychiatric patients.
AB  - This application of stepwise discriminant analysis explores a way to structure
      skewed-sample interview data, discusses some implications of the results and the
      conceptual limitations of assumptions about deviancy, and suggests a focus for
      future studies of the complex phenomena of drug abuse. The methodology differs
      from previous reports in that it uses a constant probability level, letting the
      computational procedure determine the number of significant variables. It also
      provides a method of determining the "chance" level (the amount of correct
      classification when there are no differences between the groups) so that the
      observed correct classification values may be usefully interpreted.

PMID- 1017911
TI  - A unique approach to methadone maintenance service delivery.

PMID- 1017912
TI  - Prediction of successful response to multimodality treatment among heroin
      addicts.
AB  - In an effort to identify predictor variables associated with successful response
      to multimodality treatment among heroin addicts, this investigation compared
      addict-clients classified by means of behavioral ratings into success and failure
      groups on 16 social history and 18 psychological variables using stepwise
      discrimination techniques. Statistical analyses correctly classified 100% of the
      treatment failure group and 92% of treatment successes. Successful clients were
      characterized by more advanced educational achievement at intake, later onset of
      opiate use, higher scores on MMPI Scales Es and L, and lower scores on MMPI Scale
      7. Results suggest that collection and nanlyses of such data at intake may
      provide a reliable basis for prediction of treatment outcome as well as an
      objective means for early identification of "high risk" individuals who may
      require a more concentrated and individualized therapeutic effort.

PMID- 1017913
TI  - Evaluation of drug prevention programs by youths in a middle-class community.
AB  - Based on an analysis of data fron a survey of middle-class junior and senior high
      school youths in a New York City surban community, this paper examines: (1) young
      peoples' reaction to various drug prevention programs in which they have involved
      and (2) the program topics they would like to see discussed. Important
      relationships are found to exist between substance use, prevention program
      evaluations, and desired program topics. The results suggest that the youths
      selectively relate to and want prevention experiences that confirm their
      substance relationships.

PMID- 1017914
TI  - Retention of patients in the New York City methadone maintenance treatment
      program.
AB  - The retention, termination, and readmission of patients admitted to the New York
      City Methadone Maintenance Program from November 1970 through the end of 1973
      were analyzed. Sixty-seven percent of patients remained in continuous treatment
      for 1 year and 50% for 2 years. The retention of patients admitted in successive
      years declined. Women had somewhat higher retention than men, as did patients
      over age 30 compared with those 30 or under; there were no differences among
      ethnic groups. Termination rates were determined for specific reasons for
      termination from the program as a function of length of time in treatment and
      also for calendar trimesters. A sharp increase in the rate of voluntary
      terminations was noted during the second and third trimesters of 1973. Rates of
      readmission to the program were obtained, specific for reason for first
      termination and length of time in initial treatment. One out of five terminated
      patients was readmitted to the program within 24 months.

PMID- 1017915
TI  - Minamata disease with a long-term follow-up.

PMID- 1017916
TI  - Pathogenesis of mental retardation in amino acid disorders.

PMID- 1017917
TI  - Historical reflections on the backgrounds of neurophysiology: inhibition,
      excitation, and integration of activity.

PMID- 1017918
TI  - Connections of superficial and internal adrenal veins.
AB  - Histologic specimens, microangiograms, as well as corrosion and dissection
      preparations of 220 human adrenals were evaluated in order to determine the
      venous pattern. All the glands were subjected to examination after injection of
      Micropaque into the central vein. Numerous connections of intra-and
      extraglandular veins were demonstrated. They varied in calibre from a few microns
      to 2 mm. The distribution of anastomoses was not uniform. They was much more
      numerous of the anterior aspect than on the posterior of renal surfaces of the
      gland. The anastomoses play an important part in adrenal function and adrenal
      circulation, creating the possibilty of bidirectional onflow of the venous blood
      from the gland. Such venous arrangement permits to ligate safely the central vein
      and to fill both venous systems (intra-and extraglandular) with opaque medium
      during adrenophlebography.

PMID- 1017919
TI  - Tumours of the testis. A report of 128 cases.
AB  - The records of 128 patients treated between 1960 and 1971 at the University
      Hospital, Lund, because of tumour of the testis were analysed in respect of age
      at onset of the tumour, symptoms, histology, diagnosis, treatment and survival
      rate. Teratoma occured in 67 cases, in the majority at the age of 20-30 years.
      Treatment consisted in orchiectomy, lymphadenectomy, administration of
      cytostatics and radiation alone or combined, depending upon the histology and
      spread of the tumour. The 5-year survival rate was 40%. Sixty-one patients had
      seminoma, most of which appeared between 30 and 40 years of age. The patients
      were treated with orchiectomy and radiation. The 5-year survival rate was 82%.

PMID- 1017920
TI  - Uremic autonomic neuropathy: evaluation of ephedrine sulphate therapy for
      hemodialysis-induced hypotension.
AB  - The hemodynamic response to ephedrine sulphate were studied in a patient on
      maintenance hemodialysis therapy with chronic renal failure due to renal
      amyloidosis. The evaluation (including cardiac catheterization studies) and
      estimation of responses to Valsalva maneuvers before and after ephedrine
      administration documented the diagnosis of autonomic insufficiency. Oral
      ephedrine failed to influence the episodes of severe dialysis-induced
      hypotension. Also the patient did not benefit from the infusion of Aramine. These
      studies suggest that catecholamine stores of adrenergic nerves may be depleted in
      uremic patients with clinical signs of autonomic neuropathy.

PMID- 1017921
TI  - Double renal biopsy with Menghini needle.
AB  - The complications of percutaneous renal biopsy with Menghini needle, performed in
      400 cases by the author, are reviewed. Position of the kidney was located by
      intravenous pyelography and was checked by further radiography if 1. the
      pyelogram was of inadequate technique, 2. the kidneys were small, or 3. ptotic.
      In two thirds of the cases the specimens were taken in duplicates, so as to
      provide sufficient material for light-, electron-, polarization-microscopic and
      immunofluorescent studies. On the evidence of the present observations the
      technique of double biopsy involves no higher incidence of complications than the
      conventional procedure, nor did it cause complications of major severity in the
      individual cases.

PMID- 1017923
TI  - Food consumption trends in Ireland.

PMID- 1017922
TI  - Q fever in the Republic of Ireland.

PMID- 1017924
TI  - Glucose tolerance in viral hepatitis.

PMID- 1017925
TI  - Left colon reconstruction of the pharynx after pharyngolaryngectomy.

PMID- 1017926
TI  - Non-paraprotein producing myeloma.

PMID- 1017927
TI  - Typing of hyperlipoproteinemia in an Israel hospital.
AB  - In this study we report on lipid and lipoprotein levels among a patient
      population at the Hadassah University Hospital, Jerusalem. The normal group
      consisted at 65 examinees whose mean plasma cholesterol and triglyceride levels
      were 208 and 104 mg/dl, respectively. Lipoprotein lipid levels were determined
      after ultracentrifugation and specific polyanion precipitation. All procedures
      were monitored by lipoprotein electrophoresis on paper. The mean levels of very
      low density, low density and high density lipoproteins of the normal group,
      expressed as cholesterol, were 24, 140 and 44 mg/dl, respectively. Of the 285
      patients investigated, 280 were classified as having lipoprotein patterns of type
      IIa (117), IIb (90) or IV (73); two patients had type III; and three patients had
      type V hyperlipoproteinemia. All groups differed considerably in their plasma
      lipid and lipoprotein levels. Based on individual values the ratios of plasma
      triglyceride to plasma cholesterol and plasma triglyceride to very low density
      lipid cholesterol were calculated. The low density lipoprotein cholesterol
      content was also calculated by subtracting the high density lipoprotein and an
      assumed very low density lipoprotein cholesterol content (plasma triglyceride
      level divided by 5) from the total plasma cholesterol. It is suggested that by
      the use of these values, together with lipoprotein electrophoretic procedures,
      the ocrrect typing of hyperlipoproteinemia can be established for most patients,
      without the use of the ultracentrifuge.

PMID- 1017928
TI  - Effects of exposure to Finnish sauna.
AB  - Pathophysiological effects of exposure to Finnish sauna (80 to 90 C, 30 to 40%
      relative humidity) were investigated in 60 volunteers--33 men and 27 women aged
      between 18 and 63 years. The volunteers entered the sauna after a rest period of
      20 min, and remained there for 20 min or until they suffered discomfort. Weight,
      height, rectal and skin temperatures, blood pressure, heart and respiratory rates
      and ECG were recorded 20 min prior to the sauna, during the sauna, and 20 min
      after leaving the sauna. Marked physiological changes appeared in the first few
      minutes in the sauna without any prodromal warning. At the 20th min the mean
      heart rate was 143 +/- 25 (SD) beats/min (greater than 160 beats/min in 32% of
      the subjects). Mean rectal temperature was 38.6 +/- 0.6 (SD) C (greater than 39 C
      in 22%): mean skin temperature was 40.4 +/- 1 (SD) C (greater than 40 C in 35%);
      mean systolic blood pressure was 130.5 +/- 26.6 (SD) mm Hg (greater than 160 mm
      Hg in 17%); and mean diastolic pressure was 66.6 +/- 15.9 (SD) mm Hg (greater
      than 50 mm Hg in 17%). The mean total sweat loss was 457 +/- 264 (SD) g. Three
      subjects experienced syncope, and one developed an anginal attack; ECG changes
      suggestive of coronary insufficiency were recorded. No decrease in blood pressure
      occurred in patients with preexisting high blood pressure. It is concluded that
      sauna bathing involves dangers to the bather's health, which may appear suddenly,
      without prodromal warning signs.

PMID- 1017929
TI  - Cardiovascular complications in matched pairs of low and normal renin
      hypertensive patients.
AB  - A nomogram for plasma renin activity (PRA), based on 31 normal volunteers, was
      constructed, and the 95% tolerance limits were computed to the regression line of
      PRA on 24-h urinary sodium excretion. On this nomogram, reproducibility of the
      PRA profile for the same patient with essential hypertension was good.
      Retrospectively, 20 essential hypertension patients with low PRA were matched for
      age and sex with essential hypertension patients with normal PRA. No
      statistically significant difference was found between the two groups in either
      the number of cardiovascular complications or in the blood pressure means. It is
      concluded that the incidence of cardiovascular complications tends to be similar
      in all cases of essential hypertension of a similar degree of severity.

PMID- 1017930
TI  - Variations in acoustic admittance related to type of ear tip. A plea for a
      standardized method.
AB  - In order to assess the validity of using various ear tips, tympanometry and
      acoustic admittance were studied in 20 young healthy subjects, and three
      different types of ear tip used to seal the external auditory canal. Significant
      variations in the admittance components and tympanometry curves were observed,
      resulting most probably from changes in the canal volume and the physical nature
      of the tipe. It appears advisable to develop and adopt an appropriate, standard
      ear tip for studies of admittance audiometry.

PMID- 1017931
TI  - Effect of levan on the stages of development of experimental allergic
      encephalomyelitis.
AB  - Experimental allergic encephalomyelitis was induced in male guinea pigs of the
      N13 strain by inoculation of an emulsion of basic protein of myelin with complete
      Freund's adjuvant. The disease was also passively transferred to other animals of
      the same strain by i.p. injection of sensitized lymphocytes obtained from donors
      inoculated with the antigenic emulsion eight days previously. Daily
      administration of levan markedly reduced the incidence and severity of the
      disease in actively sensitized animals. Little, if any, effect was obtained by
      levan treatment of animals with the passively transferred disease. The findings
      indicate that the previously reported inhibitory effect of levan on the
      development of experimental allergic encephalomyelitis is probably due mainly to
      a derangement of the afferent path (stage of sensitization). Administration of
      levan also causes a depletion of lymphocytes in the lymph nodes and this may
      presumably also affect the efferent path.

PMID- 1017932
TI  - Echocardiographic findings in constrictive pericarditis. A case report.
AB  - The echocardiographic findings in a 73-year-old woman with constrictive calcified
      pericarditis are presented. The diagnosis was confirmed by physical examination,
      chest X-rays and cardiac catheterization. The echocardiogram demonstrated
      abnormal motion of the interventricular septum and of the left ventricular
      posterior wall, multiple thickened echoes of the posterior pericardium, and a
      localized dense band of anterior pericardial echoes, which corresponded to the
      calcification seen on the chest X-ray.

PMID- 1017933
TI  - Prenatal diagnosis of heterozygous beta-thalassemia.
AB  - The parents of a child with homozygous thalassemia of the beta O variety
      requested prenatal diagnosis during a subsequent pregnancy. At the 19th week of
      pregnancy, a sample of blood containing fetal cells was obtained by
      placentocentesis. Radiochromatography of globin chains demonstrated production of
      a beta-chain with a beta/gamma synthetic ratio of 0.049, which is low for this
      gestational age. The conclusion that the child would be heterozygous for the beta
      thalassemia gene was confirmed after birth.

PMID- 1017934
TI  - Hypercalcemia during the polyuric stage of acute renal failure.
AB  - Hypercalcemia developed during the polyuric phase of acute renal failure in a
      patient with crush injury. The hypercalcemia persisted for one week, with a
      maximal serum calcium level of 13.1 mg/dl. Possible mechanisms for the
      hypercalcemia are discussed, with emphasis on the combined effect of extensive
      tissue damage and acute renal failure.

PMID- 1017935
TI  - Chordal rupture: a common complication of myxomatous degeneration of the mitral
      valve.
AB  - In two patients with a clinical picture of acute mitral insufficiency, the
      presence of chordal rupture secondary to myxomatous degeneration of the mitral
      valve was disclosed during surgery. There was no evidence of previous rheumatic
      valvulitis, subacute bacterial endocarditis or other etiologies. It appears from
      the literature and from the cases described that ruptured chorda tendinea is a
      not uncommon complication of myxomatous transformation of the mitral valve. While
      this fact has been mentioned in anatomophological reports, clinicians are less
      aware of the association. In the absence of supportive evidence for a rheumatic
      or arteriosclerotic etiology, a clinical picture of acute mitral insufficiency
      should suggest ruptured chorda tendinea secondary to myxomatous degeneration of
      the mitral apparatus. This is particularly true in older patients, especially
      among those followed for a midsystolic click-late systolic murmur or an apical
      pansystolic murmur of pure mitral regurgitation.

PMID- 1017936
TI  - Osteogenesis imperfecta with mitral insufficiency due to ballooning of the mitral
      valve. A case report.
AB  - A further case of osteogenesis imperfecta with valvular heart disease is added to
      the 12 already reported in the literature. The presence of a dilated mitral
      annulus and a ballooned mitral leaflet in this case together with the findings
      reported in the literature leave little doubt as to the relationship between the
      valvular lesion and the underlying connective tissue disorder.

PMID- 1017937
TI  - Membrane-bound immunoglobulin on cells on effusions from patients with malignant
      diseases.

PMID- 1017938
TI  - Cholesterol content of gallstones in Israel.

PMID- 1017939
TI  - Predictive value of cervical dilatation rates in labor in multiparous women.
AB  - A modified version of Philpott's partogram, previously used by us to analyze
      patterns of labor in primiparous and grand multiparous women in Israel, was
      applied to multiparous women. The results for labor in multiparous women closely
      resemble those found for primiparous and grand multiparous labors. The rate of
      cervical dilatation, as measured early in the active phase of labor [initial rate
      (IR)], is an accurate indicator of the outcome of labor. Ninety-eight percent of
      all multiparas with an IR of cervical dilatation of 0.75 cm/h or greater
      delivered spontaneously. Sixty-two percent of women with an IR of less than 0.75
      cm/h required an assisted delivery or cesarean section. Mean IR of cervical
      dilatation for spontaneous deliveries, assisted deliveries, and cesarean sections
      were, respectively, 1.53, 0.67, and 0.46 cm/h. No significant differences were
      observed among different population groups. Cervical dilatation rates among all
      parities appeared similar. The only major difference was in dilatation rates for
      assisted delivery in primiparas, which were faster than in labors in multiparous
      or grand multiparous women.

PMID- 1017940
TI  - Fertility and perinatal and infant mortality in the Jewish population of
      Beersheba and the Negev, 1972.
AB  - There were 4,569 Jewish births in the Negev (southern Israel) in 1972, the first
      year of birth registration by the Unit for Evaluation and Planning of Kupat Holim
      and the Ben-Gurion University center for Health Sciences. The crude birth rate
      was 28.8 per 1,000 population, with 130.7 live births per 1,000 women aged 15 to
      44 years. Total fertility was 3.9 per woman, varying from 3.4 in the kibbutzim
      and 3.5 in Beersheba to 5.2 in the moshavim (collective settlements) and 3.7 to
      6.3 in the development towns. Late fetal and perinatal death rates were 9.4 and
      19.0/1,000, and the neonatal and infant mortality rates, 11.0 and 18.1/1,000
      respectively. The proportion of males was 0.51, the twinning rate was 9.5/1,000
      women delivered, and 1.1% of babies were illegitimate. Low birth weight (less
      than 2.5 kg) was recorded in 6.9% of births. Fifty-three percent of births were
      to immigrant mothers from North Africa; the remainder were divided equally among
      mothers born in Israel, the Asian Near East, and Western countries. The Asian
      immigrant group was at high risk for infant death, with a rate of 3.64/1,000 as
      compared with 14.8, 14.2 and 5.8 recorded for the offspring of mothers born in
      Israel, North Africa and Western countries, respectively. Patterns of mortality
      in relation to maternal age, birth order and education were similar to those
      reported for developed countries.

PMID- 1017941
TI  - Tay-Sachs disease in a Moroccan Jewish family:  a possible new mutation.
AB  - The parents of a Jewish Moroccan family, in which a previous child had died of
      Tay-Sachs disease, both proved to be carriers of the mutant gene. Hexosaminidase
      A activity in the father was similar to that in Ashkenazic heterozygotes, while
      the mother showed extremely low hexosaminidase A activity in peripheral
      leukocytes. Amniocentesis was performed on the mother during a subsequent
      pregnancy; the fetus proved to be affected and the pregnancy was interrupted.
      Acrylamide isoelectrofocusing of fetal liver and leukocytes of additional family
      members revealed a variant mutation for Tay-Sachs disease.

PMID- 1017942
TI  - Frequency and distribution of sister chromatid exchanges in human peripheral
      lymphocytes.
AB  - The frequency and distribution of sister chromatid exchanges (SCE) were examined
      in a population of 10 normal individuals (five males and five females) and
      compared with those in patients with various numerical and structural chromosomal
      aberrations. Statistically significant differences within each group were
      observed among the normal subjects as well as among patients with similar
      cytogenetic aberrations. A consistent nonrandom distribution of SCE, with regard
      to chromosome length, was demonstrated, with a significant increase of SCE in the
      centromere region of some chromosomes.

PMID- 1017943
TI  - Coexistence of factor XI (plasma thromboplastin antecedent) deficiency and
      Gaucher's disease.
AB  - The findings of Factor XI (plasma thromboplastin antecedent) deficiency in a
      patient with Gaucher's disease was investigated. A family study, which included
      measurements of leukocyte glucocerebrosidase activity and Factor XI levels,
      revealed that the two genetic disorders segregated independently. One of 12
      additional unrelated patients with Gaucher's disease showed a diminished Factor
      XI level and two of seven unrelated  Factor XI-deficient patients showed
      decreased glucocerebrosidase activity. It is possible that the common occurrence
      of both genetic disorders results from a high gene frequency of both defects in
      Ashkenazic Jews.

PMID- 1017944
TI  - Effect of calcium content of diet on absorption of diphenylhydantoin.
AB  - The effect produced by changes in the calcium content of the diet on the plasma
      concentration of diphenylhydantoin was studied. In subjects on a high calcium
      intake, plasma diphenylhydantoin levels were significantly lowered, probalby
      resulting from both the formation of an insoluble calcium-drug complex and the
      direct effect of calcium on the intestinal membrane. A similar but less
      pronounced effect was observed when calcium-rich foods were excluded from the
      diet. These observations indicate the need for a balanced calcium diet during
      diphenylhydantoin treatment.

PMID- 1017945
TI  - Chronic saline loading in anoxic renal failure in rats.
AB  - The effect of saline loading was compared in two types of experimental acute
      renal failure--due to i.m. administration of glycerol or to anoxia. In the
      glycerol model, chronic saline loading for about three weeks  prior to the
      experiment achieved almost complete prevention of the uremia. The blood urea and
      serum creatinine levels 24 h after the experiment were 44 +/- 2 and 1.3 +/- 0.3
      se) mg/dl, respectively. The values for the water-drinking rats were 292 +/- 23
      and 3.7 +/- 0.4 mg/dl, respectively. In the anoxic model of acute renal failure,
      produced by uninephrectomy and contralateral renal artery clamping, chronic
      saline loading reduced the severity of the resultant uremia, although less
      impressively than in the glycerol model. The blood urea and serum creatinine 24 h
      after the experiment were 148 +/- 15 and 1.8 +/- 0.2 mg/dl, respectively. The
      values for the water-drinking rats were 237 +/- 15 and 2.3 +/- 0.2 mg/dl,
      respectively. Plasma renin activity was similar in the saline-loaded rats in both
      the toxic and anoxic models. It seems, therefore, that all known models of acute
      renal failure have at least a common pathogenic mechanism, which can be
      influenced by chronic saline loading prior to onset of the disease, and which is
      most probably not renin dependent. In the anoxic model additional factors, which
      cannot be counteracted by chronic saline loading, are active in the development
      of uremia.

PMID- 1017946
TI  - Distribution of room size in hospitals.
AB  - In the design of such complex buildings as hospitals the planner's problem is to
      provide a minimal amount of permanent structure so that it shall not get in the
      way of functional behavior of the occupants and their ability to change their
      environment. The purpose of this study was to discover which intervals seem to
      occur in hospitals by measuring the room size distribution found in existing
      buildings or buildings ready for construction. The results seem to confirm that
      the range of room sizes required is small and that exceptions are relatively
      rare.

PMID- 1017947
TI  - How many beds should a hospital department serve?
AB  - Departmental cost functions are constructed for selected hospital departments,
      using total number of beds in the hospital served as a proxy output measure.
      Calculation of maxima or minima for the resulting cost functions reveals that, on
      average, different departments have extremes in their cost functions of different
      levels of output. A relative cost index is constructed, using parameters of the
      departmental cost functions, and departmental costs are compared across regions.
      The significance of departmental differences in optimum output is discussed with
      regard to sharing of services and modified system design.

PMID- 1017948
TI  - Episodes of illness and access to care in the inner city: a comparison of HMO and
      non-HMO populations.
AB  - Using data from a 1974 household survey, accessibility to ambulatory care is
      compared for residents of an inner-city area (East Baltimore) whose usual source
      of care is an HMO (the East Baltimore Medical Plan) and residents of the same
      area with other usual sources of care. Accessibility is measured by the
      probability of receiving care for an episode of illness. Results from
      multivariate linear and probit regressions indicate that children using the HMO
      are more likely to receive care than are children with other usual care sources,
      but no significant differences in the probability of receiving care are found
      among adults. Evidence of a substitution of telephone care for in-person care is
      also found among persons using the HMO. Data from a 1971 household survey of the
      same area suggest that selectivity is not an important confounding factor in the
      analysis.

PMID- 1017949
TI  - A social systems model of hospital utilization.
AB  - A social systems model for the health services system serving the state of New
      Mexico is presented. Utilization of short-term general hospitals is viewed as a
      function of sociodemographic characteristics of the population and of the supply
      of health manpower and facilities available to that population. The model
      includes a network specifying the causal relationships hypothesized as existing
      among a set of social, demographic, and economic variables known to be related to
      the supply of health manpower and facilities and to their utilization. Inclusion
      of feedback into the model as well as lagged values of physician supply variables
      permits examination of the dynamic behavior of the social system over time. A
      method for deriving the reduced form of the structural model is presented along
      with the reduced-form equations. These equations provide valuable information for
      policy decisions regarding the likely consequences of changes in the structure of
      the population and in the supply of health manpower and facilities. The
      structural and reduced-form equations have been used to predict the consequences
      for one New Mexico county of state and federal policies that would affect the
      organization and delivery of health services.

PMID- 1017950
TI  - An approach to an index of hospital performance.
AB  - Two indexes are described, based on measures of administrative effectiveness and
      patient care effectiveness. The measures used were selected and ranked by a
      Delphi panel from a list of 30 measures drawn from the literature. Weights were
      assigned by the panel to 19 selected measures. The resulting indexes did well in
      a test on data collected from 32 Texas hospitals.

PMID- 1017951
TI  - [Synthesis of 1,3-disubstituted adamantanes (author's transl)].

PMID- 1017952
TI  - Transformations of 9 alpha, 10 alpha-epoxy-hexahydrocannabinol acetate.

PMID- 1017953
TI  - Isolation and structure of eucosterol and 16beta-hydroxyeucosterol, two novel
      spirocyclic nortriterpenes, and of a new 24-nor-5alpha-chola-8, 16-diene-23-oic
      acid from bulbs of several Eucomis species.

PMID- 1017954
TI  - [The aromatic amino acid constituent of echinocandin B: 3, 4
      dihydroxyhomotyrosine (author's transl)].

PMID- 1017955
TI  - [Homoisoflavonones. IV. New constituents of the eucomin series of Eucomis bicolor
      (author's transl)].

PMID- 1017956
TI  - [Synthesis of a homologous 3beta-hydroxycard-5,22-dienolide (author's transl)].

PMID- 1017957
TI  - The crystal structure of axillarine hydrobromide ethanol solvate: a pyrrolizidine
      alkaloid.

PMID- 1017958
TI  - The stimulation of the cholesterol synthesis in rat liver by hydrocortisone.

PMID- 1017959
TI  - [Stereospecific synthesis of two 9,11,12,13, 13a, 14
      hexahydrodibenzo(f,h)pyrrolo(1,2-beta)isoquinolines (author's transl)].

PMID- 1017960
TI  - Isolation and identification of three urinary metabolites of retinoic acid in the
      rat.

PMID- 1017961
TI  - Preferred spatial arrangement of the aromatic side chains in linear oligopeptides
      containing tyrosine.

PMID- 1017962
TI  - Cinchona alkaloids. Total synthesis of cinchonamine.

PMID- 1017963
TI  - Conversion of penicillin to cephalosporin lactones.

PMID- 1017964
TI  - [Identification of alkyl-5H-6,7-dihydrocyclopenta[b]pyrazines in roasted meat
      flavor. Model reaction used as basis for natural product formation and new
      synthesis (author's transl)].

PMID- 1017965
TI  - [Synthesis of alkyl-5H-cyclopenta[b]pyrazines (author's transl)].

PMID- 1017966
TI  - [13C-NMR. Studies on ion-selective liquid membranes (author's transl)].

PMID- 1017967
TI  - The absolute configuration of the glutarimide antibiotics streptimiodone and 9
      methylstreptimidone.

PMID- 1017968
TI  - [Investigations on the distribution of the stereoisomeric muscarines within the
      order of agaricales (author's transl)].

PMID- 1017969
TI  - 13C-NMR. Spectroscopy of naturally occurring substances. XLV. Iboga alkaloids.

PMID- 1017970
TI  - [Synthesis and absolute configuration of clemastine and its isomers (author's
      transl)].

PMID- 1017971
TI  - [Isolation and identification of two beta-carbolins in roasted chicory root
      (author's transl)].

PMID- 1017972
TI  - [Metabolites from microorganisms. Conocandin, a new fungi-static antibiotic
      (author's transl)].

PMID- 1017973
TI  - Photochemistry of imidazolides. I. The photo-Fries-type rearrangement of N
      substituted imidazoles.

PMID- 1017974
TI  - Photochemistry of imidazolides II. C2-C3 cleavage of carboxylic acid chains. A
      convenient new method for the side-chain degradation of bile acids and of
      lanosterol.

PMID- 1017975
TI  - [Synthesis of human insulin. III. Preparation of the A(14-21) - B(17-30) fragment
      (author's transl)].

PMID- 1017976
TI  - Total synthesis of indole and dihydroindole alkaloids. IX. Studies on the
      synthesis of bisindole alkaloids in the vinblastine-vincristine series. The
      biogenetic approach.

PMID- 1017977
TI  - [Synthesis of the macrocyclic spermidine alkaloids oncinotine, neooncinotine,
      isooncinotine and pseudoonicotine in racemic forms (author's transl)].

PMID- 1017978
TI  - [Role of the duodenum and antrum on the regulation of pressure in the lower
      esophageal sphincter in dogs].

PMID- 1017979
TI  - [Biliary atresia].

PMID- 1017980
TI  - Psychological and neurodevelopmental outcome of high risk newborn infants.
AB  - Among 142 high-risk-newborns, 111 could be regularly followed-up to 3 years of
      age. 79 (71%) are normal, 6 (5.5%) have minor neurological sequels, 9 (8.1%) have
      major neurological sequels, associated in 4 cases with mental deficiency, 16
      (14.5%) have developmental abnormalities (speech delay, behavioral problems,
      perceptual-motor and praxis disturbances), and one mental deficiency without
      neurological sequels. Neonatal cerebral distress proved to be the most dangerous
      clinical situation with regard to the ultimate neurodevelopmental prognosis
      (73.6% of neurological sequels or developmental abnormalities). The presence of
      transient abnormalities of tone in the course of the first year of life was
      associated with ultimate developmental abnormalities in 33.3% of the cases.
      Social and cultural status seemed to play a role in the intellectual, linguistic
      and perceptual-motor performance of this group of infants. In spite of these
      encouraging results, the need for a systematic long term follow-up of high risk
      newborns is stressed, since neurological sequels and developmental abnormalities
      are approximately 4 times more frequent in this group than in a normal infantile
      population.

PMID- 1017981
TI  - [Early treatment of cerebral movement disorders: findings among 50 school
      children].
AB  - It is difficult to assess objectively the effectiveness of treating children with
      cerebral palsy during the first year of life. 50 pupils with cerebral palsy were
      selected for handicap and intelligence and carefully examined. All children were
      treated with the neurodevelopmental technique of BOBATH, 22 of them within the
      first year of life, 28 thereafter. The examination in school age showed
      differences between the two groups. When treatment is commenced before nine
      months of age, children with spastic diplegia resulting from premature birth are
      unlikely to require special schooling for reasons of their physical handicap.
      After early treatment, patients with severe neuromuscular dysfunction in early
      life frequently display disturbances of a predominantly ataxic nature when
      reaching school age. Spasticity appears to respond well and athetosis less
      favorably to early treatment. More severe brain damage in the early treated
      children is possibly indicated by the higher incidence of epilepsy. Pupils who
      were treated early show significantly fewer behavioural disturbances, with the
      exception of cases where symbiotic neurosis in the mother is present. This is
      important for the development of the personality and the individual capacity of
      integration.

PMID- 1017982
TI  - Cutaneous pO2-measurements in newborns with respiratory distress syndrome.
AB  - Correlation between cutaneously measured pO2-values and arterial pO2 in 9
      newborns with respiratory distress syndromes was investigated with the Basel skin
      electrode [3]. At an electrode temperature of 42 degrees C, correlation was low
      (r = 0.63), at 43 degrees C the coefficient increased to 0.71 at 44 degrees C the
      over all statistical correlation improved markedly (r = 0.97). cpO2 for given
      paO2-values, however, varied widely: reliable discrimination between hypo-, normo
      and hyperoxemia was impossible. Continuous registration allows recognition of
      the consequences of common clinical situations and nursing manipulations on cpO2.
      The electrode, however, is still susceptible of technical modifications.

PMID- 1017983
TI  - Hepatic toxicity of antituberculous drugs in children.
AB  - Three cases of children who developed hepatic toxicity of different degree while
      on antituberculous treatment with isoniazid and rifampicin are reported. The
      clinical picture is presented and the pathogenesis of the hepatic damage is
      discussed. The pathological findings in the liver are those of a drug induced
      hepatitis. The combined treatment of tuberculosis in children with isoniazid and
      rifampicin is potentially dangerous and should be reserved for cases in which
      resistance to other drugs has been demonstrated.

PMID- 1017984
TI  - Lethal neonatal argininosuccinate lyase deficiency in four children from one
      sibship.

PMID- 1017985
TI  - Vascular obstruction of the superior renal calyces in children.
AB  - The authors describe 5 cases with a pathology peculiar to the superior calyces
      due to vascular compression, observed from 1969 to 1975 among 938 urographic
      tests performed in the Pediatric Clinic of Florence. Three of these cases have
      been checked up to this date. In every patient the urographic tests show clear
      evidence of a vascular compression at the level of the right upper calyces,
      associated with stasis and/or ectasis. In two cases there is a symptomatology of
      abdominal pains; in the remaining 3 patients haematuria is revealed. It is
      important, particularly in children, to follow the course of the clinical and
      urographic features, in order to carry out a surgical intervention at the right
      moment, according to the evolution of the process. The chronic segmental (upper
      pole) pyelonephritis is the most dangerous evolution.

PMID- 1017986
TI  - Primary proximal renal tubular acidosis; A therapeutical approach and long term
      follow-up.
AB  - This paper reports a case of proximal renal tubular acidosis followed during 4
      years, in a 4-year-old girl. High doses of alkali could not be administered owing
      to gastric intolerance of the patient; diuretic therapy carries the risk of
      causing severe dehydration or hypotension. We administered such a dose of NaHCO3
      to obtain a normal blood pH--with persistent hyperventilation-, subnormal
      bicarbonatemia, and acid urine. This treatment could cause an improvement of
      rickets, growth and laboratory data. At present, the biochemical data, including
      urinary excretion of bicarbonate with normal bicarbonatemia, are normal; this
      indicates a spontaneous recovery of the syndrome. We think that low doses of
      alkali are useful in the transient form of proximal renal tubular acidosis to
      prevent bone lesions and failure to thrive. But even in the irreversible form of
      this syndrome--when high alkali doses and diuretics cause dangerous effects--this
      therapy may be useful to treat some symptoms.

PMID- 1017987
TI  - Transplantation of psychiatrists from foreign cultures.

PMID- 1017988
TI  - Systems theory in psychoanalysis.

PMID- 1017989
TI  - Role strain in high-commitment career women.

PMID- 1017990
TI  - Psychoanalysis and the behavioral therapies.

PMID- 1017991
TI  - Parenting in the single parent family.

PMID- 1017992
TI  - Death trend and adaptation: a psychoanalytic theory of accident.

PMID- 1017993
TI  - Anger as a basis for a sense of self.

PMID- 1017994
TI  - Neurotic dependency in successful women.

PMID- 1017995
TI  - The retreat from a psychiatry of people.

PMID- 1017996
TI  - Developing and maintaining the therapeutic alliance with the narcissistic
      personality.

PMID- 1017997
TI  - Dreams stimulated by the analyst-patient relationship.

PMID- 1017998
TI  - The effects of fatherless homes upon daughters: clinical impressions regarding
      paternal deprivation.

PMID- 1017999
TI  - The emotional stress of psychotherapeutic practice.

PMID- 1018000
TI  - Death as a determinant of psychosomatic syndromes in Africa.

PMID- 1018001
TI  - Some notes and an exercise with regard to male homosexuality.

PMID- 1018002
TI  - The therapeutic use of writing in the service of the ego.

PMID- 1018003
TI  - On the homology of the alisphenoid.
AB  - The relationships of the elements of the cavum epiptericum in a hypothetical
      primitive mammalian precursor are reconstructed, and these are analysed in
      relation to the development of recent mammals, especially the fruit bat
      Nyctinomus johorensis. The alisphenoid in mammals is part cartilage bone, part
      membrane bone. The mammalian homologue of the primitive reptilian processus
      ascendens appears to be internal to the maxillary nerve. If so, then the 'lamina
      ascendens', that portion of the alisphenoid of mammals which lies between
      maxillary and mandibular nerves, cannot be a true processus ascendens but must be
      neomorphic. It is suggested that the mammalian lamina ascendens arose from an
      upgrowth of the root of the quadrate ramus of the epipterygoid in cynodonts,
      separating foramen rotundum from foramen ovale. In Ditremata the alisphenoid is
      completed by an element of membrane bone; this, it is suggested here, originated
      as the anterior lamina of the periotic in cynodonts, which is retained in
      monotremes. It is suggested that the alicochlear commissure of mammals originated
      as the later flange of the periotic in cynodonts.

PMID- 1018004
TI  - An autoradiographical study of [3H]thymidine incorporation into subcutaneously
      transplanted mouse molar teeth. Cell proliferation and migration in transplanted
      teeth.
AB  - Mice bearing either allografts or isografts of 10 day old molar teeth were
      injected with [3H]thymidine to identify proliferating and migrating cells within
      the graft and surrounding tissues. In isografts proliferating cells were found
      successively in the area underlying the cervix, in the cervical pulp and the
      coronal pulp. However, cells did not migrate from the cervical host tissue into
      the pulp, and it was concluded that donor cells are responsible for reparative
      processes in tooth isografts. Very few labelled cells were identified at any time
      in tooth allografts, which were not repaired. It is suggested that allografts are
      not repaired because allogeneic inhibition prevents the residual donor tissue
      from proliferating and differentiating. Inhibition of proliferation of residual
      cells may also account for the absence of a cell-mediated immune response to
      tooth allografts.

PMID- 1018005
TI  - The interfrontal bone and mutant genes in the mouse.
AB  - The relationship between corrected skull width and the presence and size of an
      interfrontal bone is discussed with regard to the effect of certain mutant genes
      in the mouse known to affect the development of the neural tube. All genes
      reviewed which increase the incidence of the interfrontal bone and affect the
      neural tube also change the proportions of the adult skull.

PMID- 1018006
TI  - Retardation of bone growth in triamcinolone-treated mice.
AB  - Immature mice were treated for up to 8 weeks with daily doses of triamcinolone
      diacetate. The epiphyseal cartilage plate and its surrounding bone from the
      humeral head were studied histologically at regular intervals. Concomitantly,
      roentgenographic measurements were performed on the humeri in toto. By the tenth
      injection significant morphological changes were noted in the cartilaginous
      plate, followed by complete cessation of bone growth. Severe triglyceride
      accumulation appeared in the experimental livers and humeral bone marrow.
      Osteoporosis also occurred and became severe from the fifth week of triamcinolone
      administration. Possible explanations for the above findings are discussed.

PMID- 1018007
TI  - The functional anatomy of the bronchial circulation of the domestic fowl.
AB  - The bronchial circulation was studied in 25 adult domestic fowls. The right and
      left bronchial arteries originated caudal to the syrinx from a bronchoesophageal
      artery which is a branch of the right common carotid artery. Each bronchial
      artery ramified on the wall of the extrapulmonary part of the corresponding
      primary bronchus and finally anastomosed directly with a branch of the pulmonary
      artery at the hilus of the lung. Thr bronchial artery did not accompany the
      intrapulmonary part of the primary bronchus. The branches of each bronchial
      artery formed an anastomosing network on the wall of the extrapulmonary part of
      the primary bronchus. The calibre of the bronchial artery at its anastomosis with
      the branch of the pulmonary artery was greater than at its origin from the
      bronchoesophageal artery. Intravenous injections of Lycopodium spores indicated
      that the blood flows from the pulmonary artery into the bronchial artery. Small
      bronchial veins drained the extrapulmonary part of the primary bronchus into the
      pulmonary vein and the oesophageal veins. The intrapulmonary part of the primary
      bronchus was supplied by branches of the pulmonary artery and drained by
      tributaries of the pulmonary vein. The blood supply to the primary bronchus could
      constitute a shunt capable of passing blood from the pulmonary artery into the
      pulmonary vein without going through the exchange tissue. The parabronchial
      (atrial) muscles received a blood supply directly from the exchange tissue via
      septal venules which formed a network underneath the muscle bundles, without
      actually penetrating between the muscle cells. These venules drained into atrial
      veins which were tributaries of the pulmonary vein. The atrial muscles probably
      also received oxygen by direct diffusion from the parabronchial lumen. The pleura
      was supplied by the oesophageal branches of the bronchoesophageal artery, and by
      small twigs from the internal thoracic and intercostal arteries.

PMID- 1018008
TI  - Cyto-differentiation and portal vascular development in the mouse
      adenohypophysis.
AB  - Pituitaries of fetal and postnatal (15 days p.c.-28 days p.n.) and adult (male)
      mice were studied by light and electron microscopy to correlate the developmental
      pattern of the hypothalamo-hypophysial vascular system with the time of onset of
      function of the adenohypophysis. The superior and anterior regions of the
      adenohypophysis become vascularized at 17 days p.c., when portal vessels extend
      from oral primary plexus to the pars distalis for the first time.
      Adenohypophysial vascularity and the number of portal vessels steadily increase
      to reach the adult pattern at 5 days p.n. At 1 day p.n. deep capillary loops
      appear in the caudal regions of the oral primary plexus; a capillary (tangential)
      plexus underlies the ependymal lining of the third ventricle by 6 days p.n.
      Superficial capillary loops were not observed until the third postnatal week.
      Granulation of secretory cells commences at 16 days p.c., predominantly in the
      upper and anterior adenohypophysis; at 17 days thyrotropes, gonadotropes and
      corticotropes are recognizable and by morphological criteria appear actively
      secretory on days 17-18 p.c., although few appear active at 19 days p.c. and 1
      day p.n. Somatotropes are first seen at 18 days p.c., predominantly in the
      central and lateral regions of the pars distalis. Active secretory cells increase
      in number over the period 2-10 days p.n., but after 11 days p.n. thyrotropes and
      corticotropes seem to become progressively less active; fewer gonadotropes are
      seen after 15 days p.n., and these apparently become progressively less active
      from day 19. Most somatotropes appear active until 28 days p.n. The observations
      suggest that hypothalamic control of adenohypophysial function may exist in the
      mouse from 17 days p.c.

PMID- 1018009
TI  - The nerve supply and conducting system of the human heart at the end of the
      embryonic period proper.
AB  - The nerve supply and conducting system were studied in a stage 23 human embryo of
      exceptional histological quality. The nerves on the right side arose from
      cervical sympathetic and from cervical and thoracic vagal filaments. Out of their
      interconnexions vagoxympathetic nerves emerged, which (1) sent a branch in front
      of the trachea to the aorticopulmonary ganglion, thereby supplying arterial and
      venous structures, and (2) formed the right sinal nerve, which supplied the sinu
      atrial node, and gave filaments to the interatrial septum which could be traced
      to the atrioventricular node and pulmonary veins. The nerves on the left side
      arose similarly from cervical sympathetic and from cervical and thoracic vagal
      filaments. These formed several descending, ganglionated, vagosympathetic
      filaments that descended to the right of the arch of the aorta and entered the
      aorticopulmonary ganglion. Filaments leaving the ganglion supplied the pulmonary
      trunk, ascending aorta, interatrial septum, pulmonary veins, and, as the left
      sinal nerve, the fold of the left vena cava. The thoracic vagal filaments
      descended to the left of the arch of the aorta and supplied chiefly the arterial
      end of the heart. No thoracic sympathetic cardiac filaments were found. The sinu
      atrial node began as a crescentic mass in front of the lower part of the superior
      vena cava. It gradually extended on each side of the superior vena cava and came
      to form its posterior wall at a more caudal level. The atrial myocardium that
      formed the septum spurium, venous valves, and interatrial septum could be traced
      from the sinu-atrial to the atrioventricular node. Myocardium also encircled the
      atrial aspects of the atrioventricular orifices, and could be traced caudally to
      the atrioventricular nde. The atrioventricular node was a conspicuous mass in the
      anterior and lower part of the interatrial septum, from which a clearly defined
      bundle left to enter the interventricular septum. Right and left limbs were
      observed, the former being a rounded bundle that passed immediately in front of
      the root of the aorta.

PMID- 1018010
TI  - Plantar aponeurosis and internal architecture of the ball of the foot.
AB  - On the basis of its internal structure, the ball of the foot can be divided into
      three transverse areas, each with a different mechanical function: (1) an area
      proximal to the heads of the metatarsals in which the retinacula cutis are
      developed into a series of transverse bands, and in which the deep fibres of the
      plantar aponeurosis form ten sagittal septa connected to the deep transverse
      metatarsal ligament and through this the proximal phalanges of the toes, (2) an
      area below the heads of the metatarsals in which vertical fibres from the joint
      capsules and the sides of the fibrous flexor sheaths form a cushion below each
      metatarsal head, and in which fat bodies  cover the digital nerves and vessels in
      their passage between the cushions, and (3) a distal area which comprises the
      interdigital web. The superficial fibres of the plantar aponeurosis are inserted
      into the skin of this distal area, and deep to them the plantar interdigital
      ligament forms a series of transverse lamellae connected to the proximal
      phalanges by a mooring ligament which arches from one fibrous flexor sheath to
      the next. When the metatarsophalangeal joints are extended, the fibres of the
      three areas are tensed and the skin is anchored firmly to the skeleton. The
      direction of the fibres in the distal and proximal area promotes the transfer of
      forces exerted on the skin during push-off and braking respectively, while the
      intermediate area is adapted to bear the weight of the body. A concentration of
      Pacinian corpuscles is found along the digital nerves in the weight-bearing area
      below the transverse metatarsal ligament. The nerves for the second, and
      especially for the third, interstice are close to or in contact with the sharp
      proximal edges of the sagittal septa.

PMID- 1018011
TI  - Vascular segments in the human spleen.
AB  - Corrosion casts of human splenic arterial trees revealed the presence of two
      segments-a superior, and an inferior - in 84% of cases and three segments - a
      superior, a middle and an inferior - in 16% of cases. These segments are
      separated by avascular planes.

PMID- 1018012
TI  - Substrate limitation of bacterial growth at meat surfaces.

PMID- 1018013
TI  - Enzymic breakdown of amino acids and related compounds by suspensions of washed
      mycobacteria.

PMID- 1018014
TI  - An adaptable system for timed aseptic sampling and storage of microbial cultures.

PMID- 1018015
TI  - Action of chondroitinases. II. Numerical calculation of the degree of multiple
      attack.
AB  - Further investigation was carried out on the action patterns of two
      chondroitinase-AC [EC 4.2.2.5.] preparations obtained from Arthrobacter aurescens
      and Flavobacterium heparinum. To infer the action patterns of the
      chondroitinases, we proposed a new method for the calculation of the degree of
      multiple attack, based on the concept established by Robyt and French ((1967)
      Arch. Biochem. Biophys. 122, 8-16). It was shown that the degree of multiple
      attack (DM) is represented by the ratio of the initial velocity of number-average
      degree of scission to that of viscosity-average degree of scission. By this
      method, DM for A-Chase was estimated to be 3.03 and for F-chase, 1.31.

PMID- 1018016
TI  - Preferential acid-catalyzed hydrolysis of the formamide linkage of N'
      formylkynurenine in frozen solution.
AB  - Acid-catalyzed hydrolysis of the formamide linkage of N-acetyl-N'-formyl-L
      kynurenineamide in frozen dilute hydrochloric acid solution followed first-order
      kinetics, yielding N-acetyl-L-kynurenineamide as the sole reaction product. The
      maximum rate of reaction in the frozen solution was found at around -7.5 degrees
      and approximated that of the reaction in liquid solution at 40 degrees. By
      freezing the dilute acid solution at -8 degrees the reaction was accelerated by
      60 times compared with that in super-cooled liquid solution at the same
      temperature.

PMID- 1018017
TI  - A study of the native-denatured (N in equilibrium with D) transition in lysozyme.
      II. Kinetic analysis of protease digestion.
AB  - Kinetic analyses of the protease digestion of several chemical derivatives of
      lysozyme [EC 3.2.1.17] showed that only the D(denatured) state of the protein is
      digested and that the reaction velocity is proportional to the equilibrium
      constant (KD) of the N in equilibrium with D transition of the protein.
      Alteration of the net charge of lysozyme by acetylation caused a shift of the N
      in equilibrium with D transition to the right (ten-fold increase in KD compared
      to that of native enzyme). Both the formation of a lysozyme-inhibitor complex and
      the introduction of a covalent bond in the lysozyme molecule restricted the
      transition. The magnitude of the N in equilibrium with D transition is related to
      the susceptibility of lysozyme to protease digestion and it is estimated that the
      N in equilibrium with D transition in proteins is generally important in the
      intracellular catabolism of proteins.

PMID- 1018018
TI  - A method for the deductive and unique determination of the values of three
      parameters involved in fractional functions applicable to relaxation kinetics.
AB  - A novel method is proposed to determine deductively and uniquely the values of
      three parameters, a, b, and c in a fractional function of the form, y=a+bx/(c+x)
      where x and y are experimentally obtainable variables. This type of equation is
      frequently encountered in chemistry and biochemistry involving relaxation
      kinetics. The method of least squares with the Taylor expansion is employed for
      direct curve fitting of observed data to the fractional function. Approximate
      values of the parameters, which are always necessary prior to commending the
      above procedure, can be obtained by the method of rearrangement after canceling
      the denominator of fractional functions. This procedure is very simple, but very
      effective for estimating provisional values of the parameters. Deductive and
      unique determination of the parameters involved in the fractional function shown
      above can be accomplished for the first time by the combination of these two
      procedures. This method is extended to include the analysis of relaxation kinetic
      data such as those of temperature-jump method where the determination of
      equilibrium concentrations of reactants in addition to the three parameters is
      also necessary.

PMID- 1018019
TI  - Incorporation of [14C]glucose from UDP[14C]glucose into a phosphoglycolipid by
      cell-free particulate systems of a moderately halophilic gram-negative bacterium,
      Pseudomonas halosaccharolytica ATCC 29423.
AB  - A glucosyl group from uridine diphosphate [U-14C]glucose is incorporated into a
      phosphoglycolipid, probably a glucosylphosphatidylglycerol, by a disrupted
      membrane enzyme preparation from a gram-negative, moderately halophilic
      bacterium, Pseudomonas halosaccharolytica ATCC 29423. The conversion of
      [14C]phosphatidylglycerol into phosphoglycolipid by the particulate preparation
      was also enhanced in the presence of non-labelled UDP-glucose. A chemical
      degradation study of labelled phosphoglycolipid showed the bulk of the
      radioactivity from UDP[U-14C]glucose to be associated with the glucose moiety,
      which also appeared to be attached to the hydroxyl group of a second glycerol.

PMID- 1018020
TI  - Polyamine-dependent deoxyribonuclease activity from rat-liver nuclei.
AB  - When nuclei isolated from rat liver in a low salt buffer were washed with 0.1 M
      NaCl solution, the supernatant showed a deoxyribonuclease (DNase) activity. The
      activity required Mg2+ and in addition spermine or spermidine, and its optimal pH
      was 7.2-7.4. The activity was higher on denatured (single stranded) DNA than on
      double-helical DNA. With both substrates the activity was highest at a polyamine
      concentration at which the DNA-polyamine complex began to precipitate. No
      Mg2++Ca2+ dependent DNase activity was detected in the preparation.

PMID- 1018021
TI  - The effect of inositol hexaphosphate on the absorption spectra of alpha and beta
      chains in nitrosyl hemoglobin.
AB  - The spectral changes of nitrosyl hemoglobin on addition of inositol hexaphosphate
      were studied in hybrid-heme hemoglobins. The results showed that the decrease in
      absorption in the Soret region was mainly due to a spectral change in alpha
      chains, and that the tension on heme in the quaternary T structure was much
      stronger in alpha than in beta chains.

PMID- 1018022
TI  - An anomaly in the resonance Raman spectra of cytochrome P-450cam in the ferrous
      high-spin state.
AB  - Resonance Raman spectra of cytochrome P-450cam (P-450cam) and its enzymatically
      inactive form (P-420) in various oxidation and spin states were measured for the
      first time. The Raman spectrum of reduced P-450cam was unusual in the sense that
      the "oxidation-state marker" appeared at an unexpectedly lower frequency (1346 cm
      1) in comparison with those of other reduced hemoproteins (approximately 1355
      approximately 1365 cm-1), whereas that of oxidized P-450cam was located at a
      normal frequency. This anomaly in the Raman spectrum of reduced P-450cam can be
      explained by assuming electron delocalization from the fifth ligand, presumably a
      thiolate anion, to the antibonding pi orbital of the porphyrin ring. The
      corresponding Raman line of reduced P-420 appeared at a normal frequency (1360 cm
      1), suggesting a status change or replacement of the fifth ligand upon conversion
      from P-450cam to P-420. The Raman spectrum of reduced P-450cam-metyrapone complex
      was very similar to that of ferrous cytochrome b5.

PMID- 1018023
TI  - Amino acid composition of peptidoglycan in Caulobacter crescentus.
AB  - Peptidoglycan of a gram-negative stalked bacterium, Caulobacter crescentus CB13,
      contained alanine, diaminopimelic acid, and glutamic acid, in molar ratios of 2 :
      1 : 1. The amino acid compositions of peptidoglycans isolated from cultures
      enriched in swarmer and stalked cells, and from a stalk-less mutant were similar.
      This finding conflicts with a previous observation that swarmer peptidoglycan
      does not contain diaminopimelic acid (Goodwin and Shedlarski (1975) Arch.
      Biochem. Biophys. 170, 23-36). It appears that, despite the morphological
      differences, the Caulobacter cells all contain a similar peptidoglycan in the
      cell wall.

PMID- 1018024
TI  - The site-specific deoxyribonuclease from Bacillus pumilus (endonuclease
      R.Bpu1387).
AB  - A new site-specific endonuclease (DNase) was isolated from the cells of Bacillus
      pumilus AHU 1387 strain. This enzyme (endonuclease R.Bpu 1387) introduced double
      stranded scissions at unique sites on DNA's of coli phage lambda, lambdadvl, coli
      phage T7, Bacillus phage phi105C, Bacillus phage SP10, and Simian Virus 40, in
      the presence of magnesium ion. The activity was stimulated by the presence of
      NaCl.

PMID- 1018025
TI  - The choice of treatment in Pott's disease.

PMID- 1018026
TI  - The operating microscope isn't everything--a warning and a prediction.

PMID- 1018027
TI  - A five-year assessment of controlled trials of in-patient and out-patient
      treatment and of plaster-of-Paris jackets for tuberculosis of the spine in
      children on standard chemotherapy. Studies in Masan and Pusan, Korea. Fifth
      report of the Medical Research Council Working Party on tuberculosis of the
      spine.
AB  - In two centres in Korea 350 patients with a diagnosis of tuberculosis of the
      thoracic and/or lumbar spine were allocated at random: in Masan to in-patient
      rest in bed (IP) for six months followed by out-patient treatment or to
      ambulatory out-patient treatment (OP) from the start; in Pusan to out-patient
      treatment with a plaster-of-Paris jacket (J) for nine months or to ambulatory
      treatment without any support (No J). All patients recieved chemotherapy with PAS
      with isoniazid for eighteen months, either supplemented with streptomycin for the
      first three months (SPH) or without this supplement (PH), by random allocation.
      The main analysis of this report concerns 299 patients (eighty-three IP, eighty
      three OP, sixty-three J, seventy No J; 143 SPH, 156 PH). Pre-treatment factors
      were similar in both centres except that the patients in Pusan had, on average,
      less extensive lesions although in a greater proportion the disease was
      radiographically active. One patient (J/SPH) died with active spinal disease and
      three (all No J/SPH) with paraplegia. A fifth patient (IP/PH) who died from
      cardio respiratory failure also had pulmonary tuberculosis. Twenty-three patients
      required operation and/or additional chemotherapy for the spinal lesion. A sinus
      or clinically evident abscess was either present initially or developed during
      treatment in 41 per cent of patients. Residual lesions persisted in ten patients
      (four IP, two OP, one J, three No J; six SPH, four PH) at five years. Thirty-two
      patients had paraparesis on admission or developing later. Complete resolution
      occurred in twenty on the allocated regimen and in eight after operation or
      additional chemotherapy or both. Of the remaining four atients, all of whom had
      operation and additional chemotherapy, three died and one still had paraparesis
      at five years. Of 295 patients assessed at five years 89 per cent had a
      favourable status. The proportions of the patients responding favourably were
      similar in the IP (91 per cent) and OP (89 per cent) series, in the J (90 per
      cent) and No J (84 per cent) series and in the SPH (86 per cent) and PH (92 per
      cent) series.

PMID- 1018028
TI  - Quantitative histology of the human growth plate.
AB  - This paper describes a study in the human femur of the relationship between cell
      division in growth cartilage and overall bone growth. Growth rates for the distal
      femur from birth to eighteen years were determined from serial radiographs
      available from the Harpenden Growth Study; An average of 1-4 cm/year was found
      for the ages of five to eight years. The development of the growth plate is
      illustrated in a series of photomicrographs of femur sections. These sections
      were also used for quantitative histology; The length of the proliferation zone
      was estimated from cell counts to be twenty-four cells per column. On the basis
      of this value and the measured growth rate, an approximate mean cycle time of
      twenty days was found for the proliferating cells of the human growth plate.
      Since the corresponding cycle time is two days for rodent growth plates, which
      also have a different structure, it is unwise to extrapolate the findings in this
      tissue from mouse to man.

PMID- 1018029
TI  - Mechanical function as an influence on the structure and form of bone.
AB  - Rosette strain gauges were attached to the cranial and caudal aspects of the
      proximal half of the radius in eight skeletally mature female sheep; The sheep's
      radius has a slight cranially convex curvature. During walking it was deformed so
      that the cranial surface was subjected to tension aligned along the bone's lon
      axis, and the caudal surface to compression similarly aligned. The compressive
      strain on the caudal aspect of the bone was consistently larger (X 1-9) than the
      tensile strain on the cranial aspect. The thickness of the cortex did not reflect
      this difference but in younger animals the process of osteonal remodelling seemed
      further advanced in the cortex which was customarily subject to the larger
      deformation. The relevance of these findings is discussed in relation to the
      technique of internal fixation and to our understanding of the basis of the
      mechanical adaptability of bone.

PMID- 1018030
TI  - The aetiology of congenital angulation of tubular bones with constriction of the
      medullary canal, and its relationship to congenital pseudarthrosis.
AB  - It is suggested that there is a group of cases of congenital angulation of
      tubular bones in which the lesion is a defect of ossification of the primary
      cartilaginous anlage and in which neurofibromatosis is not implicated. It appears
      that in this group the prognosis with regard to the resolution of deformity and
      the prevention of pseudarthrosis with conservative treatment or relatively simple
      surgical procedures is better than that in the neurofibromatous type.

PMID- 1018031
TI  - The pathogenesis of Perthes' disease.
AB  - It has been shown that in the puppy, two infarcts separated by an interval of
      four weeks produce a disorder of long duration which results in flattening and
      broadening of the femoral head and which reproduces the radiological changes seen
      in Perthes' disease in man. The histological appearances produced by two infarcts
      are characteristic. In this study the histological appearance of fifty-seven
      femoral head biopsy specimens in Perthes' disease in man have been studied. In 51
      per cent of hips histopathological changes characteristic of double infarction
      were present, and there were grounds for postulating that double infarction might
      eventually occur in all cases. The findings support the concept that the
      deformation of the femoral head and the chronicity of Perthes' disease in man may
      be due at least as much or even more to repeated episodes of infarction and the
      ensuing abnormalities of growth as to mechanical factors related to weight
      bearing.

PMID- 1018032
TI  - Spondylolytic fractures.
AB  - A method is described whereby fractures of the neural arch similar to those in
      spondylolysis are produced experimentally. The forces, bending moments and
      displacements required to initiate the fractures are given; The mechanical
      aspects in the aetiology of spondylolysis are explained by a simplified two
      dimensional force analysis.

PMID- 1018033
TI  - Fracture-dislocations of the sacrum. Report of three cases.
AB  - The pattern of fracture-dislocation of the upper part of the sacrum is
      demonstrated in three patients. The fracture line followed the segmental form of
      the sacrum and was usually caused by a posterior force against the pelvis which
      had been locked by hip flexion and knee extension. Fractures of the lumbar
      transverse processes also occurred, presumably from avulsion by the quadratus
      lumborum muscle. The damage to the sacral plexus found in all three cases
      recovered after several months. Radiographs of the injury are difficult to obtain
      in severely injured patients but oblique views of the sacrum help to determine
      the extent of the forward dislocation.

PMID- 1018034
TI  - Successful replantation of a hand amputated through the metacarpus.
AB  - A successful replantation is reported of a hand completely severed by a circular
      saw through all five metacarpals. The sequence of primary reconstruction of all
      important structures beginning three hours after the injury and the functional
      results eighteen months later are presented.

PMID- 1018035
TI  - The clinical manifestations and pathomechanics of contracture of the extensor
      mechanism of the knee.
AB  - Experience with thirty-eight Asian children and adolescents who presented with
      either stiffness of the knee, genu recurvatum, habitual dislocation of the
      patella or congenital lateral dislocation of the patella showed that all those
      disorders were manifestations of contracture of the extensor mechanism, which
      fell into two groups according to the components involved. In Group I the main
      components affected were in the midline of the limb, namely rectus femoris and
      vastus intermedius; these patients presented with varying degrees of stiffness of
      the knee, or worse, with genu recurvatum. In Group II the main components
      involved were lateral to the midline of the limb, namely vastus lateralis and the
      ilio-tibial band; these patients presented with habitual dislocation of the
      patella, or worse, congenital lateral dislocation of the patella. In both groups
      untreated patients developed secondary adaptive changes such as subluxation of
      the tibia or marked genu valgum which made operative procedures more formidable
      and less effective. Release of the contracture should therefore be performed as
      early as possible.

PMID- 1018036
TI  - Excision of the head of the radius in rheumatoid arthritis.
AB  - The results of excision of the head of the radius in forty-four elbows affected
      by rheumatoid arthritis are presented. Relief of pain was obtained in 90 per cent
      and an increase in the range of flexion and extension was seen in 70 per cent.
      Involvement of the humero-ulnar joint seen radiologically is no contra-indication
      to the operation; simple excision of the radial head often gives gratifying
      results; In our experience the relief of pain and increased range of movement
      have greatly reduced the need for total replacement arthroplasty.

PMID- 1018037
TI  - Radial club hand with absence of the biceps muscle treated by centralisation of
      the ulna and triceps transfer. Report of two cases.
AB  - Two children with radial club hand and absence of the biceps muscle were treated
      by centralisation of the ulna into the carpus and triceps transfer. The two
      operations were performed only a short time apart so that the period between the
      procedures could be used to stretch the triceps and to enable the children to
      adapt to an altered position of the wrist and to mobility of the elbow at one
      step and following a single period of plaster immobilisation. It is very likely
      that function is better than it would have been had the condition remained
      untreated. Before operation the children had only a crude hook function of the
      hand against the forearm and could not bring the hand to the mouth. Even if
      function is not much improved, the improvement in appearance is considerable and
      is by itself sufficient to justify the procedures.

PMID- 1018038
TI  - Whence the arthrogrypotics?
AB  - During the course of a nation-wide survey of patients with bone and joint
      deformities, twenty-six individuals with arthrogryposis multiplex congenita, in
      the narrow and precise sense of the term, were investigated. No patient was more
      than twenty-four years of age. However, on a basis of the figures of population,
      it can be estimated that 21-0 +/- 6-5 older affected individuals should have been
      encountered. Furthermore, there was a relative excess of younger children. The
      series was reasonably unbiased, and as arthrogryposis is non-lethal the
      deficiency of affected adults is an anomalous finding. It is tentatively
      suggested that arthrogryposis might result from the intra-uterine influence of an
      unknown environmental agent which has been present in South Africa for only a
      limited period of time. Detection of this factor could be an important step in
      the prevention of the disease.

PMID- 1018039
TI  - An operation for chronic prepatellar bursitis.
AB  - An operation for chronic prepatellar bursitis is described in which only the
      posterior wall of the bursa is excised, thus preserving, undamaged, healthy and
      normally sensitive skin. This procedure is easier and less traumatic than
      complete excision of the bursa and results in fewer complications. It is
      suggested that removal of tha anterior wall of the bursa results in unnecessary
      and harmful interference with the underlying skin. The operation described gives
      a good functional and structural result; leaving the anterior wall of the bursa
      does not predispose to recurrence.

PMID- 1018040
TI  - The locked patella. An unusual complication of haemophilia.
AB  - Mechanical derangements of the knee are an uncommon complication of chronic
      haemophiliac arthropathy. Two patients with locking of the patella were treated
      by manipulation. The mechanism of the injury was forced flexion of the knee joint
      beyond the limit of its restricted range. The injury is a serious one and may
      take six months to recover.

PMID- 1018041
TI  - Pollen ultrastructure in anther cultures of Datura innoxia. I. Division of the
      presumptive vegetative cell.
AB  - Ultrastructural features of embryogenic pollen in Datura innoxia are described,
      just prior to, during, and after completion of the first division of the
      presumptive vegetative cell. In anther cultures initiated towards the end of the
      microspore phase and incubated at 28 degrees C in darkness, the spores divide
      within 24 h and show features consistent with those of dividing spores in vivo.
      Cytokinesis is also normal in most of the spores and the gametophytic cell-plate
      curves round the presumptive generative nucleus in the usual highly ordered way.
      Further differentiation of the 2 gametophytic cells does not take place and the
      pollen either switches to embryogenesis or degenerates. After 48-72 h, the
      remaining viable pollen shows the vegetative cell in division. The cell, which
      has a large vacuole and thin layer of parietal cytoplasm carried over from the
      microspore, divides consistently in a plane parallel to the microspore division.
      The dividing wall follows a less-ordered course than the gametophytic wall and
      usually traverses the vacuole, small portions of which are incorporated into the
      daughter cell adjacent to the generative cell. The only structural changes in the
      vegetative cell associated with the change in programme appear to be an increase
      in electron density of both plastids and mitochondria and deposition of an
      electron-dense material (possibly lipid) on the tonoplast. The generative cell is
      attached to the intine when the vegetative cell divides. Ribosomal density
      increases in the generative cell and exceeds that in the vegetative cell. A thin
      electron-dense layer also appears in the generative-cell wall. It is concluded
      that embryogenesis commences as soon as the 2 gametophytic cells are laid down.
      Gene activity associated with postmitotic synthesis of RNA and protein in the
      vegetative cell is switched off. The data are discussed in relation to the first
      division of the embryogenic vegetative cells in Nicotiana tabacum.

PMID- 1018042
TI  - Pollen ultrastructure in anther cultures of Datura innoxia. II. The generative
      cell wall.
AB  - In young pollen grains of Datura innoxia, a wall of the usual hemispherical type
      separates the 2 gametophytic cells initially and, in the electron microscope,
      appears as an electron-translucent matrix which is contiguous with the intine.
      Before detachment of the generative cell from the intine, the matrix decreases in
      thickness and in places is dispersed altogether leaving the plasmalemmae on
      either side of it in close apposition. A particularly prominent zone, triangular
      in profile, is left where the wall joins with the intine. After detachment of the
      cell, remnants of the matrix can be seen distributed irregularly around the cell
      and it is supposed that these are partly derived from material in the triangular
      zone as the cell is drawn away from the intine. The wall residues persist
      throughout the maturation phase of the pollen and are considered to be either
      callose resulting from incomplete digestion of the initial wall, or some other
      polysaccharide material which is unevenly laid down along the wall and
      concentrated at the junction with the intine. In pollen induced into
      embryogenesis by anther culture, wall material is also distributed irregularly
      around the detached cell in a series of discrete zones, but these are more
      extensive than in vivo, closer together and in many instances highly dilated. The
      wall profiles thus have a beaded appearance, the 'beads' being connected together
      by short links of the 2 apposed plasmalemmae. The contents of the swollen zones
      have a similar electron density to that of the matrix in vivo but also show
      traces of a fibrillar component. It is postulated that this unusual swelling is a
      prelude to dispersal of the wall by disruption of the plasmalemmal links and to
      the establishment of cytoplasmic continuity between the 2 cells. The significance
      of such binucleate pollen grains in the formation of non-haploid embryos is
      discussed.

PMID- 1018043
TI  - Pollen ultrastructure in anther cultures of Datura innoxia. III. Incomplete
      microspore division.
AB  - During the microspore division in Datura innoxia, the mitotic spindle is oriented
      in planes both perpendicular (PE) and oblique (OB) to the spore wall against
      which the nucleus is situated. However, irrespective of polarity, the usual type
      of hemispherical wall is laid down at cytokinesis and isolates the generative
      cell from the rest of the pollen grain (type A). In PE spores the vegetative
      nucleus initially occupies a central position in the pollen grain, whereas in OB
      spores the vegetative nucleus lies at the periphery of the grain close to the
      generative cell. In anther cultures initiated just before the microspore division
      is due to take place, no marked change can be observed in either orientation or
      symmetry of the mitotic spindle when the spores divide. In some, however,
      cytokinesis is disrupted and deposition of the hemispherical wall arrested. In
      the absence of a complete wall, differentiation of the generative cell cannot
      take place and binucleate pollen grains are formed having 2 vegetative-type
      nuclei (type B). The 2 nuclei in the B pollens are always situated against the
      pollen-grain wall, suggesting that the disruption phenomenon is related to the OB
      spores. The incomplete wall always makes contact with the intine on the intine
      side of the spindle. Wall material may be represented merely as short stubs
      projecting out from the intine into the cytoplasm, in which event the 2 nuclei
      lie close to each other and are separated by only a narrow zone of cytoplasm. In
      other grains the wall is partially developed between the nuclei and terminates at
      varying distances from the tonoplast; in these, the nuclei are separated by a
      wider zone of cytoplasm. The significance of these binucleate grains in pollen
      embryogenesis is discussed.

PMID- 1018044
TI  - Timing of nucleolar DNA replication in Amoeba proteus.
AB  - Light- and electron-microscope autoradiography have been used to follow the
      incorporation of [3H]thymidine at different stages during the interphase of
      synchronously growing populations of Amoeba proteus. Two main patterns were found
      for tritiated thymidine incorporation, i.e. DNA synthesis. The major
      incorporation was in the central region of the nucleus, but a lesser degree of
      incorporation occurred in the nucleolar region. The bulk of this nucleolar DNA
      was found to be late replicating, i.e. it replicated during the G2 phase.

PMID- 1018045
TI  - Circus movements and blebbing locomotion in dissociated embryonic cells of an
      amphibian, Xenopus laevis.
AB  - Circus movements, which involve the circumferential rotation of a hyaline
      cytoplasmic protrusion, occur in cells obtained by EDTA dissociation of gastrula
      stage Xenopus laevis embryos. Only a few dissociated blastula-stage cells show
      circus movements, more early gastrula-stage cells show them, and nearly all late
      gastrula-stage cells show them. Circus movements cease in cells prior to mitosis
      and begin again in daughter cells after mitosis is completed. In early gastrulae,
      only 17% of prospective endodermal cells show circus movements while 79% of
      prospective mesodern, archenteric roof, and posterior neural ectoderm do so.
      Isolated cells as well as groups of cells in vitro are often propelled by circus
      movements. There is an obvious antagonism between cell contact and circus
      movements. The morphogenetic significance of circus movements and blebbing
      locomotion is discussed.

PMID- 1018046
TI  - A decay of gap junctions in association with cell differentiation of neural
      retina in chick embryonic development.
AB  - Ultrastructural studies of thin-sectioned and freeze-cleaved materials were
      performed on developing retinal tissues of 3- to 9-day-old chick embryos to
      clarify the junctional structures between neural retinal cells and between neural
      retinal cells and cells of the pigmented epithelium. Frequency, size and position
      of gap junctions in developing neural retina are different at each stage of
      development. In 3-day-old embryos, some cells adhere to each other by gap
      junctions immediately below the outer limiting membrane of neural retinae. The
      size and number of gap junctions increase remarkably during 5-6 days of
      incubation. In this period of development, well developed gap junctions
      consisting of subcompartments of intramembrane particles are found between cell
      surfaces at both the outer limiting membrane region and the deeper portion of the
      neural retina. Gap junctions disappear thereafter, and at 7-5 days of incubation,
      small gap junctions are predominant between cell surfaces at the outer limiting
      membrane region, while the frequency of gap junctions in the deeper portion is
      very low. At 9 days of incubation, gap junctions are rarely found. Typical gap
      junctions are always found between neural retinal cells and those of the
      pigmented epithelium in embryos up to 7-5 days of incubation. Tight junctions are
      not found in the neural retina or between neural retina and pigmented epithelium
      throughout the stages examined.

PMID- 1018047
TI  - Gap junctions in the differentiated neural retinae of newly hatched chickens.
AB  - Gap junctions in the neural retinae of newly hatched chickens were examined in
      thin section and by freeze cleaving. Unusual gap junctions containing linear
      arrays of intramembrane particles are found between principal and accessory cones
      which form a double cone at the region of the outer limiting membrane. These
      unusual gap junctions are often continuous with macular aggregates of hexagonally
      packed intramembrane particles which are characteristic of a typical gap
      junction. Typical gap junctions are also found in both the outer and the inner
      plexiform layers and in the outer nuclear layer, but are not so abundant as in
      the outer limiting membrane region. The sizes of intramembrane particles and
      their centre-to-centre spacing within the macular aggregate of a gap junction in
      differentiated neural retinae are slightly larger than those in undifferentiated
      neural retinae. Tight junctions are not found in differentiated neural retinae.

PMID- 1018048
TI  - Mechanism of myofibril growth and proliferation in fish muscle.
AB  - The mechanisms of myofibril growth proliferation were investigated in the red and
      white muscles of fish. In both types of muscle the ratio of lattice filament
      spacings between the Z disk and M line was found to be greater than that required
      for perfect transformation of a square into a hexagonal lattice. This mismatch
      was considered to result in the thin filaments being pulled obliquely instead of
      at right angles to the Z disk. The angle of pull of the thin filaments was
      measured in longitudinal sections. The splitting process was found to decrease
      the degree of pull. Splitting was also observed in transverse sections of the
      peripheral myofibrils. In both red and white fibres these myofibrils were found
      to commence splitting when they reached a size of approximately 1-2 mum diameter.
      Evidence from ultrastructural and autoradiographical studies suggested that
      growth of the myofibrils within the fibres is centrifugal. The outermost
      myofibrils appear to be the ones which are being built up and which split. The
      data indicated that in fish muscle a considerable number of filaments may be
      added to the daughter regions whilst splitting of the myofibril is still
      continuing.

PMID- 1018049
TI  - A special pattern of the smooth endoplasmic reticulum in the kidney of the snail
      Cryptomphalus aspersa.
AB  - A special structural pattern of the smooth endoplasmic reticulum (SER) has been
      observed in the kidney of the snail Cryptomphalus aspersa. Two types of cells
      (clear and dark) cover the foldings of the renal sac; the dark cells are by far
      the most numerous. A cisterna of SER enveloping the nucleus appears invariably in
      both types of cells, with no disruptions, or small ones (from 50 to 90 nm) along
      its profile. The layer of cytoplasm lodged between the external nuclear membrane
      and this cisterna is found invariably to be from 0-20 to 0-25 mum in width.
      Glycogen is abundant in the cytoplasm as alpha particles, and also in the
      nucleus, but as beta particles. It is noteworthy that absolutely no glycogen is
      present in the layer of cytoplasm lodged between the nuclear membrane and the
      surrounding SER envelope. Long profiles of SER are also observed closely
      approaching and parallel to the plasma membrane of the dark cells. Considering
      the role of SER in glycogen metabolism in the kidney of the snail, the possible
      function of these cisternae as a support system ofr enzymes involved in the
      metabolism of glucides is discussed.

PMID- 1018050
TI  - Phagocytosis of concanavalin A in normal and enucleated cultures of mammalian
      cells.
AB  - The fate of concanavalin A (Con A) bound to normal and enucleated L cells was
      followed at the ultrastructural level over a 20-h period. In both enucleates and
      normal cells the Con A is seen to be distributed in a uniform manner over the
      entire cell surface following a 30-min pulse with a low concentration of Con A.
      In the subsequent chase period the cells then aggregate the Con A and Con A sites
      into large clusters on the cell membrane. The cells then phagocytoze the Con A
      and large phagocytic vacuoles containing it are observed. Thus, enucleated cells
      are capable of phagocytozing Con A and its sites in the same manner as normal
      cells.

PMID- 1018051
TI  - Cytoplasmic streaming in Chara corallina studied by laser light scattering.
AB  - An apparatus is described by means of which the power versus frequency spectrum
      of the photomultiplier current can be obtained for laser light scattered by
      streaming cytoplasm in the algal cell Chara corallina. A Doppler peak is noted in
      the spectrum which is abolished when cytoplasmic streaming is arrested by
      electrical stimulation. For 5 cells of Chara, this simple laser-Doppler
      velocimeter gave streaming velocities (46-7 mum s-1, S.D. +/- 4-8 at 20 degrees
      C) similar to those obtained for the same cells using the light microscope (44-3
      mum s-1, S.D. +/- 5-3 at 20 degrees C). A narrow distribution of streaming
      velocities is indicated. The technique described provides a rapid, quantitative
      assay of the in vivo rheological properties of cytoplasm.

PMID- 1018052
TI  - Assay of intercellular adhesiveness using cell-coated Sephadex beads as
      collecting particles.
AB  - A simple, rapid and precise method, based on a previous method, for measuring
      relative rates of intercellular adhesion is described. DEAE-Sephadex beads were
      treated with nitrocellulose in order to allow cells to grow on their surfaces.
      Balb/c 3T3 and Balb/c 3T12 cells were used to characterize the assay. They formed
      confluent cell layers on nitrocellulose-treated DEAE-Sephadex. These cell-coated
      beads were employed to collect 32P-labelled cells from single cell suspensions.
      Since they formed statistically uniform, large collecting surfaces, the
      collection of labelled cells was markedly improved as compared to the original
      assay. The cell-coated beads collected a large percentage of the labelled cells
      in a short time. The percentage of cells collected was independent of the
      concentration of labelled cells in the assay mixture, and the collection was
      linear for approximately 60 min. The variability between replicate assays was
      usually +/- 5%. The assay allows the rapid and precise determination of
      intercellular adhesion in large numbers of individual samples. These features
      make it useful to screen for effects of different treatments on intercellular
      adhesions.

PMID- 1018053
TI  - Mechanisms of cell adhesion: early-forming junctions between aggregating
      fibroblasts.
AB  - When cultured fibroblasts (16C) are mildly dissociated with EGTA or trypsin/EDTA,
      they aggregate rapidly. The formation of aggregates has been found to involve
      junctions of the gap and adhaerens types which are seen by electron microscopy
      within minutes of allowing cells to come together. The process of adhesion
      between freshly dissociated, transformed 16C fibroblasts is therefore organized
      and establishes its usefulness as a model for studying cellular interactions in
      relation to supracellular organization.

PMID- 1018054
TI  - Jaw mechanics during release of the stuttering moment: some initial observations
      and interpretations.
AB  - As a part of a larger study (Hutchinson and Watkin, 1974), this investigation was
      undertaken to examine jaw mechanics during the release of stuttering moments. Six
      adult subjects (four stutters, ranging in severity, and two normal talkers) read
      a series of sentences containing phonetic sequences requiring jaw depression.
      Strain-gauge transducers were employed to record articulatory movement. Only
      those stutterings occurring immediately prior to and during jaw opening were
      studied. The results confirmed generally faster jaw velocities for the opening
      and closing gestures; which was interpreted to suggest that the spindle motor
      system is maximally active to preserve synchrony in on-going vocal tract events
      following the dysfluency. In cases where an asynchrony between vocalization and
      jaw opening was noted, it was suggested that imprecision in predicting voice
      onset resulted in articulatory-laryngeal incoordination. It would appear from
      these interpretations that the clinical efficacy of the "pull out" procedure
      results from reduced demands on the gamma loop system and facilitation of
      articulatory-laryngeal synchrony through reduced supraglottal velocities.

PMID- 1018055
TI  - Traumatic aphasia in children: a case study.
AB  - Traumatic aphasia in children has been recognized as a distinct clinical
      pathology, differing from adult aphasia in symptomatology and course of recovery.
      The upper limit for complete recovery has been identified as age 10. However,
      there is a paucity of literature documenting recovery of children with traumatic
      aphasia. It is apparent that definitive statements of the upper age limit for
      complete recovery from traumatic aphasia in children cannot be made at this time.
      This article reviews the literature concerning traumatic aphasia and presents
      case information of a 10-year-old traumatic aphasic girl seen at the North Texas
      State University Speech and Hearing Center. The design, execution, and assessment
      of therapeutic interaction and the observed language abilities of the client are
      reported.

PMID- 1018056
TI  - Relationship of clinician feedback to child initiated verbalization during
      language training.
AB  - A systematic observational procedure was used to obtain frequency counts of
      client and clinician initiated interchanges and clinician feedback during these
      interchanges. Repeated recordings were made of eight different speech
      pathologists interacting with two groups of four preschool children. Child
      responses to clinician initiated interchanges received significantly more
      positive feedback than child initiated verbalizations to the clinician. However,
      considerable variation among clinicians was found both in the frequency of
      spontaneous verbalizations by their clients and their reaction to this
      verbalization. Stepwise multiple regression analyses indicated that the type and
      amount of clinician feedback for client initiated verbalizations was
      significantly related to the frequency of these utterances to the clinician, but
      not to other children.

PMID- 1018057
TI  - Cognitive conditioning therapy in the treatment of stuttering.
AB  - A therapy is described in which clients vividly imagine the cognitions that
      usually trigger their stuttering, and then contingently experience a painful
      shock. With the cessation of shock, alternate desirable cognitions are imagined
      that are designed to facilitate fluent speech. A case study illustrating the
      treatment is presented. Stuttering is compared with addictive behaviors such as
      smoking, and it is concluded that cognitive commonalities exist among seemingly
      disparate behaviors. The cognitive conditioning framework provides an integrative
      model that can be usefully applied in a variety of situations.

PMID- 1018058
TI  - Perceptual and acoustic analysis of repetitions in stuttered speech.
AB  - This study presents perceptual and acoustic data on a carefully selected set of
      part-word repetitions from the speech of adult stutters. Results indicated that
      the schwa vowel was perceived in only 25% of the repetitions, far less than
      previously indicated. Spectrographic analysis showed that although abnormal
      consonant duration and C-V formant transitions characterized the initial segment
      of the stuttered word, the remainder of the word is identical to its identical to
      its fluently produced counterpart. The results were interpreted to mean that for
      the type of dysfluency selected, the articulatory breakdown is confined to the
      initial consonant, and it is likely that abnormal formant transitions from
      initial consonant to vowel, when present, are due to deviant formation of the
      consonant rather than to faulty transition dynamics.

PMID- 1018059
TI  - A refinement of the concept "reticence".
AB  - This report has 1. Made a distinction between speech disorders involving defects
      and those that are primarily reticence, but in any case identified speech
      disorders as negotiated states as opposed to fixed disease states. 2. Argued that
      there is a clear analytical separation between speech disorders and speech
      behaviors which are indicative of neurotic disorders. 3. Attempted to remove
      anxiety as a component of the communication process by according it its rightful
      place, which is central in human personality. Furthermore, we have attempted to
      dispel the notion that anxiety is evil and the perennial (and sole) cause of
      speech disorders. 4. Identified a specialist known as the rhetoritherapist (a
      specially trained speech teacher) as the particular king of professional
      qualified to deal with speech disorders (in conjuction with speech pathologists
      and/or psychotherapists where necessary). We have accorded to the
      rhetoritherapist the province of instruction and training in all aspects of
      invention, delivery, and reception of rhetorical speech without reference to its
      moral intent. 5. Identified "reticence" as the most useful of the various
      imprecise terms used to refer to people with speech problems, because it is
      devoid of connotations that go beyond the speech process. Further refinement of
      specific categories of speech disorders is necessary to order to expand the
      repertoire of available treatment strategies. Such refinement will probably
      include reference to the various subprocesses of human speech identified earlier
      in this paper as they are related to the rhetorical situation. The
      rhetoritherapist thus emerges as the trouble-shooter, but not the
      "psychotherapist," of speech pedagogy.

PMID- 1018060
TI  - Giant and "granular melanosomes" in Leopard syndrome: an ultrastructural study.
AB  - Electron microscopy of lentigines was performed to study the pigmentation
      abnormality in two children with LEOPARD syndrome. Giant melanosomes similar to
      those seen in cafe-au-lait spots of neurofibromatosis and nevus spilus were found
      in a lentigine from one of our cases. Our results show that "spherical granular
      melanosomes" described in neurofibromatosis, are lysosomal-like structures
      associated with the development of complex melanin granules. Our study also
      demonstrates that immature melanosomes are present in some keratinocytes of
      LEOPARD syndrome. This finding is in contrast to the prevailing concept that only
      mature melanosomes are transferred to keratinocytes. The occurrence of individual
      melanosomes of normal size and shape in keratinocytes of skin in whites with
      LEOPARD syndrome, suggests that neither the size of melanosomes, nor the racial
      differences are the factors determining the distribution of melanosomes in
      keratinocytes.

PMID- 1018061
TI  - Lichenoid benign keratosis.
AB  - One hundred thirty-eight patients who presented with solitary cutaneous lesions
      appearing clinically as papules or plaques and histologically showing a lichenoid
      tissue reaction were studied. Many of the lesions occurred in sites not usually
      exposed to sunlight and histologically the lesions did not show significant
      atypical change in keratinocytes and many did not show evidence of solar
      elastosis in the superficial corium. Our study indicates that the lesions are
      benign keratoses showing a lichenoid tissue reaction or lichenoid benign
      keratoses.

PMID- 1018062
TI  - Dermal changes in osteoporosis following prolonged treatment with human growth
      hormone.
AB  - Five patients with osteoporosis were treated with human growth hormone (hGH) for
      a year and the changes in their skin were studied by light and electron
      microscopy. The abnormally thin skin of osteoporosis appeared to change towards
      normal after treatment with hGH. There was a consistent proliferation of blood
      vessels, and increased number of mast cells and fibrocytes. The collagen bundles
      and elastic tissue fibers appeared hyperplastic and more horizontally oriented.
      The fine, vertical elastic fibrils of the papillary dermis had appeared decreased
      before treatment, but seemed to be restored to their normal configuration after
      treatment. Since there was no evidence of stimulation of hair, sebum, or melanin
      such as occurs in acromegaly, it is suggested that the scope of the direct action
      of hGH on the skin is limited to mesenchymal structures.

PMID- 1018063
TI  - Deposition of complement in the lesions of experimental cutaneous candidiasis in
      guinea pigs.
AB  - Deposits of C3 have been demonstrated at the dermo-epidermal junction in the
      lesions of experimental cutaneous candidiasis in guinea pigs. The deposits were
      granular in character and similar to those previously found in the lesions of
      chronic mucocutaneous candidiasis in humans. Immunoglobulin, C4 and candida
      antigen were not detected in the lesions. C3 was also found in a similar pattern
      at the dermo-epidermal junction of candida-infected skin from homozygous C4
      deficient guinea pigs. From these observations, it is postulated that complement
      deposition occurs in these lesions as a result of alternative pathway activation,
      perhaps by cell wall components from the infecting organisms.

PMID- 1018064
TI  - Transfollicular extrusion of sebaceous glands: natural phenomenon or artifact? A
      case report.
AB  - A sebaceous gland tumor on the back of a 28-year-old man underwent periodic
      exudation of yellowish material in association with local irritation.
      Pathological examination revealed entire sebaceous gland lobes lying subcorneally
      in the orifices of sebaceous follicles. This case appears to represent
      transfollicular extrusion of sebaceous gland lobes as a natural phenomenon rather
      than as an artifact.

PMID- 1018065
TI  - Condylomata acuminata.
AB  - A 5-year-old Thoroughbred chestnut mare was presented because of multiple lesions
      noticed for approximately one year over the vulva and ther perianal areas.
      Clinically, there were moist warts that stood out because of their whitish color
      which contrasted strikingly with the surrounding, normally pigmented, uninvolved
      skin (Fig. 1). Repeated topical applications of 20% podophyllin in 95% ethyl
      alcohol produced rapid involution. Histopathologically, marked acanthosis,
      numerous mitoses, prominently vacuolated epidermal cells and a chronic dermal
      inflammatory infiltrate were seen (Figs. 2, 3, and 4). Interestingly, melanin in
      the basal cell layer was not visible in the lesions, but was very apparent in the
      normal epidermis at the edges of the lesions. Thus the contrast between the
      affected and the non-affected skin was also strikingly microscopically (Fig. 2
      arrows).

PMID- 1018066
TI  - Inhibition of adenylate cyclase by arsenite and cadmium: evidence for a vicinal
      dithiol requirement.
AB  - The effect of sodium arsenite and cadmium chloride on adenylate cyclase activity
      was examined in turkey erythrocyte membranes. Sodium arsenite was a weak
      inhibitor of adenylate cyclase -7mM produced only 60% inhibition. Its effect,
      however, was greatly potentiated by equimolar 2,3 dimercaprol- wherein 0.7 mM
      sodium arsenite inhibited 100% with an apparent Ki of 0.1 mM. Equimolar
      mercaptoethanol was less effective in potentiating sodium arsenite inhibition.
      Thus 0.7mM sodium arsenite in the presence of equimolar mercaptoethanol inhibited
      adenylate cyclase 56%. Excess 2,3 dimercaprol reversed inhibition by sodium
      arsenite or cadmium chloride. Sodium arsenite or cadmium chloride inhibited all
      forms of adenylate cyclase activity tested, including nonhormonal stimulation.
      Equimolar sodium arsenite and dimercaprol, at concentrations that caused 100%
      inhibition of adenylate cyclase activity, reduced the binding of the beta
      receptor specific ligand iodohydroxybenzylpindolol by less than 15%. These
      results suggest that turkey erythrocyte membranes contain closely juxtaposed
      thiol groups and that interaction of such groups with arsenate interferes with
      the catalytic function of adenulate cyclase.

PMID- 1018067
TI  - Glaucoma crossroads.

PMID- 1018068
TI  - Clinical and theoretical considerations of a patient with narrow angles and
      shallow anterior chambers.
AB  - Clinicians must always be on the alert to identify those individuals who appear
      to be anatomically disposed to narrow angle glaucoma. However, it is not
      axiomatic that these individuals can be provoked into an attack even if a history
      of subacute attacks exists. In this paper, and in one other to follow, the case
      histories of several interesting patients that were seen by the author for
      routine eye examinations will be discussed. The intent of the papers is to
      demonstrate that the diagnosis of glaucoma, existent or potential, can be quite
      time consuming and is dependent on far more than just tonometry.

PMID- 1018069
TI  - Adverse reactions to topical ocular anesthetics.
AB  - The purpose of this article is to clarify some of the misunderstanding about
      adverse reactions to topical ocular anesthetics. Discussion will include: types
      of adverse reactions that are theoretically and practically possible; advice on
      handling the reactions that can occur; and precautions for minimizing their
      occurrence.

PMID- 1018070
TI  - Protective spectacles for retinitis pigmentosa patients.
AB  - On the hypothesis that ophthalmic filters with appropriate light transmission
      characteristics may be beneficial in retarding the progress of retinal
      degeneration in early retinitis pigmentosa, the characteristics of several
      plastic and glass filters have been evaluated. A dark brown plastic goggle has
      been found which meets the theoretical criteria previously postulated for such
      protection. Its characteristics and those of other filters are compared with a
      lens which was specially designed for RP protection and was previously reported
      on by Adrian and Schmidt.

PMID- 1018071
TI  - Modification of Welch-Allyn "11500 ophthalmoscope for visuoscopy.
AB  - Visuoscopy is an indispensable test in the evaluation of the monocular fixation
      pattern. Unfortunately, the instrumentation needed to accurately perform the test
      is often costly. A procedure describing how the Welch-Allyn "11500 ophthalmoscope
      may be inexpensively modified for the routine performance of visuoscopy is
      presented.

PMID- 1018072
TI  - An evaluation of the use of topical anesthetics and low concentrations of
      phenylephrine HCl for mydriasis.
AB  - When used in conjunction with a topical anesthetic, low concentrations of
      phenylephrine HCl produce the same degree of mydriasis as is produced by higher
      concentrations of the drug used alone. Contrary to previously published reports,
      however, there is no evidence to suggest that the use of lower concentrations
      lessens the risk of adverse reactions. The analysis of available information
      given here suggests that the risks may in fact be increased when an anesthetic is
      used.

PMID- 1018073
TI  - Accommodative blur in pilocarpine-treated glaucoma.
AB  - Accommodative blurring of distance visual acuity is a common problem among young
      patients being treated for glaucoma with pilocarpine. A single case is reported
      in which a clip-on prescription was given to alleviate such problems. The
      development of accommodative blur following instillation of pilocarpine is
      monitored. The dioptric changes required to restore distance acuity to 20/20 are
      also monitored.

PMID- 1018074
TI  - Neurological syndromes involving the visual system.
AB  - Because optometrists are the primary deliverers of eye care, their role in
      pathology detection is of primary importance. The neurological syndromes of the
      visual system have been reviewed and put into a chart format as an aid to the
      optometric clinician.

PMID- 1018075
TI  - Polaroid photomacrography using the SX-70 camera.
AB  - This paper describes a technique for taking color photographs of the external eye
      using the Polaroid SX-70 camera and a biomicroscope. It is particularly useful in
      providing a photographic record of anomalies such as pterygium, in which the rate
      of progression across the cornea can be observed over a period of months or
      years.

PMID- 1018076
TI  - The differential diagnosis of fundus pathology,.

PMID- 1018077
TI  - Advanced retinitis pigmentosa: a case report.

PMID- 1018078
TI  - The ligaments of the wrist.
AB  - The ligaments of the wrist were studied by dissecting ten fixed and seven fresh
      frozen wrists. In three other specimens multiple cross-sections were prepared.
      These studies show that the wrist ligaments can be classified into two groups:
      extrinsic and intrinsic. In the extrinsic group, the deep volar radiocarpal
      ligaments are three strong and very important structures connecting the radius to
      the capitate, the radius to the lunate, and, in a deeper layer, the radius to
      both the scaphoid and the lunate. A ligamentous deficiency was noted frequently
      between the capitate and the lunate. There also are very strong volar connections
      between the radius and the medial or ulnar carpus. These studies suggest that
      certain patients with a generalized ligamentous laxity and weakness will develop
      a pathological disruption of the volar ligaments with trauma. These torn volar
      ligaments should be repaired or reconstructed, for repair of only the dorsal
      ligaments seldom will provide good stability to such wrists.

PMID- 1018079
TI  - Comparison of histologic and functional recovery after peripheral nerve repair.
AB  - After repair, nerve stains of skin and subcutaneous tissue biopsies of 23
      fingertips contained identifiable axons in all patients. The level of recovery
      was more advanced in some patients than in others, as manifested by identifiable
      nerve in various plexuses and receptors. Meissner's corpuscles were observed to
      be reinnervated in 12 of 17 patients and in 16 of 23 fingertips. The degree and
      level of reinnervation did not correlate with clinical testing or subjective
      impression of the result. The authors conclude that sensibility is the result of
      several factors active in the peripheral and central nervous system. Axonal
      regrowth is but one of these.

PMID- 1018080
TI  - Restoration of strong grasp and lateral pinch in tetraplegia due to cervical
      spinal cord injury.
AB  - Patients with tetraplegia who have "strong" sixth cervical neurologic (C-6)
      function often can be given active grasp and strong lateral pinch by tendon
      transfers and tenodeses. Wrist control can be retained by the extensor carpi
      radialis brevis and flexor carpi radialis and can permit transfer of the extensor
      carpi radialis longus to provide finger flexion. Either the brachioradialis or
      pronator teres then is available for transfer to restore adduction-opposition of
      the thumb with an in situ tendon graft of a paralyzed flexor superficialis
      rerouted to the thumb through a palmar fascial pulley. The other motor can
      provide thumb flexion for strong lateral pinch. Extrinsic extension can be
      provided by tendoeses. With seventh cervical neurologic (C-7) function retained,
      active digital extension is present and functional expectations are better. Ten
      hands in seven patients with traumatic tetraplegia from injuries at C-6 or C-7
      level have been reconstructed. The average grasp and pinch force after operation
      was 5.5 and 3.0 Kg., respectively. All patients but one were pleased with the
      increased function a

PMID- 1018081
TI  - The importance of middle or long finger realignment in ulnar drift.
AB  - Based upon the hypothesis that ulnar drift is the result of a chain reaction
      starting with a medial shift of the proximal phalanx at the metacarpophalangeal
      joint and progessing to subluxation of the extensor tendon and finally
      subluxation of the metacarpophalangeal joint, the author recommends early
      operative realignment. The extensor tendon is partially divided and a portion
      passed through the base of the phalanx, the intrinsic tendons are transferred to
      divided, the junctura tendnium is served, the periosteum is stripped from the
      neck of the metacarpal, and areas of bony erosions are curetted. In 25 patients
      with involvement of the middle finger only, alignment was maintained in all over
      a period of 3 months to 7 years, the average follow-up period being 1.4 years.
      When deformity was severe and the radical collateral ligament has been disrupted,
      correction was not always maintained. Early treatment is recommended.

PMID- 1018082
TI  - Squamous cell carcinoma of the nail bed.
AB  - Twenty-seven cases of squamous cell carcinoma of the nail bed seen by the author
      have been reviewed. Sixteen were thought to be primary tumors and eleven to be
      secondary to chronic exposure to radiation. All had been present for a long time
      prior to definitive treatment. The tumor was of low grade malignancy with a
      tendency to invade the distal phalanx. No metastases have been found. Treatment
      was amputation of the distal phalanx and involved tissues.

PMID- 1018083
TI  - Digital nerve grafts with the lateral antebrachial cutaneous nerve.
AB  - The lateral antebrachial cutaneous nerve was used as a nerve graft to bridge a
      defect in a digital nerve, when with the digit in full extension the nerve ends
      could not be approximated without tension. Thirteen grafts have been followed
      from 7 to 23 months. Two patients did not regain two point discrimination and
      therefore had a poor result. The remaining 11 patients recovered two point
      discrimination between 7 and 20 mm.

PMID- 1018084
TI  - Rate and extent of functional recovery after flexor tendon grafting with and
      without silicone rod preparation.
AB  - Forty-six consecutive patients requiring flexor tendon grafts were evaluated at
      4, 6, 8, 10, 12, 16, 20, 22, 24, 28, 34, and 52 weeks after grafting. The
      patients were divided into two groups: those who did not require a silicone
      rubber rod prior to tendon grafting (Group I), and those who did require a
      silicone rubber rod prior to grafting (Group II). Analysis of the rate of
      functional recovery as measured by total active motion, gross grip strength, and
      pinch grip strength showed no significant difference between the two groups.
      Analysis of the extent of functional recovery at one year, as measured by total
      active motion and distance of digital pulp from distal palmar crease, showed no
      significant differences between Groups I and II.

PMID- 1018085
TI  - Patterns of neuromuscular activity following tendon transfer in the upper limb: a
      preliminary study.
AB  - Early results of a continuing study of the electrical activity of muscles after
      transfer, with an integrated system of electromyographic and video tape
      recording, recorded motions of the simple voluntary type, mostly with isometric
      contractions. A triceps-to-biceps transfer showed activity in the new motion one
      day after operation. A partial transfer of the pectoralis major (Clark)
      demonstrated isolated activity of the transfer after one year. A superficialis
      transfer to clawed ring and little fingers functioned to flex the
      metacarpophalangeal joints and to extend the interphalangeal joints. Transfer of
      superficialis to finger extensors showed that antagonists acted to provide
      unresisted extension. The original phasic activity of a muscle was retained in a
      study of extensor indicis proprius to thumb for opposition. New phasic activity
      was shown in transfer of extensor carpi radialis longus to digital flexors. In
      two instances of transfer of spastic wrist flexors to wrist extensors, the
      original phasic activity was retained, but in only one was the function assumed
      by the transfer even though wrist extension was improved.

PMID- 1018086
TI  - The abducted little finger in low ulnar nerve palsy.
AB  - In 12 dissections the extensor digiti minimi tendons inserted into the abductor
      tubercle of the proximal phalanx. In eight of the 12, the tendons passed to the
      ulnar side of the abductor-adductor axis of the metacarpophalangeal joint. A
      separate tendon from the extensor digitorum communis to the little finger was
      found in only one dissection, with all others showing a connecting band which
      varies in its obliquity and thus in its adducting effect. To correct an abducted
      little finger, the ulnar portion of the extensor digiti minimi was transferred to
      the radial side of the little finger. Two methods were used: (1) the tendon was
      passed to the volar side of the metacarpophalangeal joint, if the joint could be
      hyperextended; if not, (2) a simple transfer to the radial collateral ligament
      was performed.

PMID- 1018087
TI  - Proximal row carpectomy with muscle transfers for spastic paralysis.
AB  - Fourteen patients with spastic paralysis from various causes (eight with cerebral
      palsy) who needed minimal two handed activities to assist in self-care and who
      desired improvement in appearance were treated by proximal row carpectomy. In
      twelve transfer of flexor carpi ulnaris to extensor carpi radialis brevis was
      done, and in two the extensors of the wrist were shortened. Various other
      procedures were done in some patients. Prolonged splinting was carried out.
      Better extension of the wrist was obtained and supination improved more when the
      transfer was subcutaneous around the ulnar border than when through the
      interosseus membrane. Less tendency for the carpus to displace ulnarward was seen
      when the distal half of the scaphoid was not removed. Strength of grasp and pinch
      improved, but ability to release objects was diminished due to the more
      dorsiflexed position of the wrist. Subjective use for two handed activities was
      improved and the patients were satisfied with the appearance.

PMID- 1018088
TI  - The pronator quadratus in motions and in stabilization of the radius and ulna at
      the distal radioulnar joint.
AB  - Based upon the findings of dissections of 15 forearms and clinical observations
      in patients with disturbed architecture of the distal radioulnar joint, the
      pronator quadratus was found to be composed of two heads. A superficial head
      originated from the ulna and passed transversely to its insertion into the
      radius. It averaged 5.1 cm. in length, 4.5 cm. in width, 0.2 cm. in thickness,
      with a cross-sectional area of 0.95 cm.2 and a contractile volume of 2.6 cm.3.
      The deep head ran obliquely from a more proximal origin on the ulna to a distal
      insertion on the radius, with an average length of 4.0 cm., average width of 3.2
      cm., and a thickness of 0.4 cm. Its average cross-sectional area was 1.64 cm.2
      and its contractile volume 2.5 cm.3. A group of fibers occasionally was noted
      deep to both heads, running at right angles to them and paralleling the direction
      of the fibers of the interosseous membrane. The superficial head initiates
      pronation while the deep head coapts the joint surfaces and stabilizes the joint.

PMID- 1018089
TI  - Opera-glass hand in rheumatoid arthritis.
AB  - Characteristic deformities occur in the fingers, thumb, and wrist in the opera
      glass hand in rheumatoid arthritis. Shortening and instability are the result of
      bone resorption and dislocation and can be severely disabling. Early spontaneous
      fusion of the proximal interphalangeal joint preserves digital length. Functional
      improvement can be obtained in the fingers by interphalangeal joint arthrodesis
      and metacarpophalangeal prosthetic arthroplasty and in the thumb with
      metacarpophalangeal and/or interphalangeal arthrodesis. With interphalangeal
      arthrodesis, interposition grafts often are required in order to restore length
      and secure fusion. "Prophylactic" arthrodesis of interphalangeal joints should be
      considered when resorption seems imminent.

PMID- 1018090
TI  - Volkmann's ischemic contracture due to soft tissue injury alone.
AB  - Fifteen upper extremities, in 14 patients in whom incipient or actual Volkmann's
      ischemic contracture was present, were seen in a 5 year period. Nine patients
      were stuporous due to drug overdose and had laid on the extremity; two had
      received a recent injury of main arterial trunks; two had sudden severe
      compression; one with chronic myelogenous leukemia had each arm involved at
      different times in a bizarre autoimmune response causing massive swelling. No
      patient had a fracture or dislocation. Pain and tenderness, loss of sensibility,
      resistant muscle contracture, and rock-hard muscle compartments were warning
      signs. Immediate fasciotomy was done. Useful function was restored when treatment
      was carried out in the early stages of the ischemia.

PMID- 1018091
TI  - The dorsal ganglion of the wrist: its pathogenesis, gross and microscopic
      anatomy, and surgical treatment.
AB  - During a period of 25 years, 500 dorsal ganglions of the wrist were treated
      surgically. Three hundred and forty-six were followed for a minimum of 9 months;
      there were three recurrences. Dissection of the cysts under magnification of six
      to 25 times and serial microscopic studies showed evidence of a one way,
      valvelike system between the scapholunate joint and the ganglion. Stress, as a
      cause of ganglions, is suggested. Operative treatment involved excising all
      attachments to the scapholunate ligament.

PMID- 1018092
TI  - Digital vessel trauma from repetitive impact in baseball catchers.
AB  - The impact to the catcher's hand in baseball was studied. Modification or
      additional padding in the glove seems indicated to prevent vascular injury.

PMID- 1018093
TI  - [Electron microscopic and light microscopic studies of optical and cortical
      afferents in the lateral geniculate body, pars dorsalis, of albino rats with
      special attention to synaptic organization].
AB  - 1. In the CGLd of the albino rat there are to be found two forms of retinal
      terminals in electronmicroscopic investigations, they are identical with 2a and
      2b terminals described formerly in Golgi-preparations. 2. The small 2b terminals
      are situated previously in the extraglomerular neuropil, which is identical with
      the terminal part of P-neuron dendrites. They establish asymmetric GRAYtype I
      contacts with dendrites and spines of the relay-cell-dendrites. 3. The large 2a
      terminals form filamentous contacts with the smooth surfaces of the dendrites of
      the stem-and branching-zones. Synaptic contacts (GRAY I) are established with the
      grape-like appendages in the branching zone of P-neuron dendrites. 4. In the
      glomeruli of the CGLd there are three main components, which are the nerve
      endings of large optic axons, the interneuron dendritic terminals and the relay
      cell-dendrites. They are surrounded by astrocytic processes. 5. In the extra
      glomerular neuropil there are numerous small nerve endings, they form GRAY type I
      contacts with relay-cell-dendrites and their spines. They are partly identical
      with the type I endings in Golgi-preparations (cortical terminals). 6. After the
      eye enucleation and ablation of the visual cortex the type 2a and 2b and type 1
      terminals degenerate. There are two forms of degeneration, the light and the dark
      one. 7. After eye enucleation two forms of degenerations in the degenerating
      retinal axons occur, which are the "watery" and the "dense" form. Besides the
      astrocytes the oligodendrocytes remove the destroyed particles. 8. The
      ultrastructural characteristics of the interneuronal dendritic terminals and
      their possible funktion are discussed. 9. There is added a table of the synonyma
      of CGLd structures.

PMID- 1018094
TI  - Histoenzymological mapping of acetylcholinesterase and butyrylcholinesterase in
      the diencephalon and mesencephalon of Uromastix hardwickii.
AB  - The paper deals with a detailed histochemical mapping of acetylcholinesterase
      (AChE) and butyrylcholinesterase (BChE) in the diencephalon and mesencephalon of
      Uromastix hardwickii. In AChE in contrast to BChE preparations, most of the
      nuclei reveal intense activity Interestingly, the hypothalamic nuclei demonstrate
      positive reactions to AChE but totally negative reactions in BChE preparations.
      The enzymatic activity in fiber tracts is totally negative for AChE; on the
      contrary, it is intensely positive for BChE. Neurosecretory substance, in the
      hypothalamic region, is positive for the two preparations of the enzymes. The
      role of these enzymes, as related to the functional activities of the various
      nuclei and fiber tracts, has also been discussed.

PMID- 1018095
TI  - [Neuron structure of the rat septum telencephali].
AB  - 1. The neuronal structure of the septum of adult rats was studied after GOLGI
      impregnation. On the basis of cytoarchitectonic investigations the septum of the
      rat was divided into three big nuclei: nuclei septalis lateralis, septalis
      medialis, and tractus diagonalis (s. ANDY and STEPHAN). 2. The nc. septalis
      medialis contains cells with pyramidal, oval, round, spindle-shaped, fusiforme or
      triangular pericarya, while in the nc. septalis lateralis cells with pyramidal
      pericarya are absent. In the nc. tractus diagonalis four different forms of cells
      bodies occur: oval, triangular, round, and parymidal ones. 3. The existence of
      single, characteristic cell forms is not restricted to certain areas within a
      nucleus; the different kinds of cells are distributed irregularly and arranged
      ina different distance. 4. Mostly after a dichotome division the dendrites spread
      into all directions (bipolar to star-shaped dendritic arborisation). An
      orientation of the dendrites of single neurones into a special direction (i.e. to
      the ventricle) was not observed. 5. Neurons of the septum have dendritic fields
      with a mean diameter of 300 mum. The dendritic diameter regularly remains
      constant in the distance between two branchings and decreases only after the
      division of the dendrite. 6. The distribution of spines on the dendrites is
      typical for interneurons. Immediately after their origin from the pericaryon the
      dividing dendrites have a segment free of spines which extends up to the first
      outgrowth of a lateral dendrite. In neurons with poorly ramified dendrites this
      spines-free segment is absent; the first spines are found close by the
      pericaryon. Bferore and after a ramification of dendrites a different density of
      spines exists. 7. The neurons of the septum are morphologically and functionally
      classified as interneurons. Their dendritic fields correspond to those of star
      cells and are even similar to pyramidal cells. For the cell types described a
      great structural variability in the dentritic arrangement occurs.

PMID- 1018096
TI  - Differences in psychological sex, adjustment, and familial influences among
      homosexual and nonhomosexual populations.
AB  - The present study investigated differences in psychological sex, present and past
      adjustment, and parental influences among homosexual cross-dressers, homosexual
      non-cross-dressers, applicants for sex change surgery, and heterosexuals. The
      homosexual non-cross dresser and heterosexual groups were found to have the most
      masculine gender role, with the sex change group having the most feminine gender
      identity. The two homosexual groups were most accepting of homosexuality, with
      the sex change group having the least acceptance of homosexuality. Support was
      not found for the prediction that the sex change group would have the worst
      present and past adjustment followed by the homosexual cross-dressers with the
      poorest past adjustment. As predicted, however, fathers were perceived as more
      nurturant in the heterosexual group than among the remaining three groups. These
      findings suggest that variations in sexual-life-style can be understood as
      manifestations of different combinations of the components of psychological sex
      and that a nurturant father is important in the development of a heterosexual
      life-style.

PMID- 1018097
TI  - Age-status labeling in homosexual men.
AB  - Ninety-five homosexual men between 25 and 68 years of age were asked to classify
      themselves as young, middle-aged, or old. Most men in their 20s and 30s described
      themselves as young; most men in their 40s and all men over 50 described
      themselves as middle-aged. The popular suggestion of accelerated aging in
      homosexual men was not supported. Homosexual men who anticipate such accelerated
      aging might possess poorer physical and or psychological health than those who do
      not.

PMID- 1018098
TI  - Homosexuality in the Rorschach: a new look at the old signs.
AB  - Content responses to the Rorschach inkblot test have been used by clinicians to
      assess homosexuality. In comparing educated, adjusted male homosexuals to
      educated, adjusted heterosexuals, no differences were found between the groups
      when the traditional index of homosexuality on the Rorschach was used. The index
      was unable to distinguish the groups on a number of criteria. The reliability of
      the index was found to be significantly greater for the homosexual group than for
      the heterosexual group. It was suggested that the traditional index is not valid
      and that it should not be used in a clinical setting as a measure to assess
      homosexuality.

PMID- 1018099
TI  - The effects of a homophile organization on the self-esteem and alienation of its
      members.
AB  - Wth the expanding number and kinds of homophile organizations, a need exists to
      evaluate the effect these organizations have upon their members. Stemming from a
      previous investigation by the author, this study of the relationship between
      membership in a homophile organization and the dependent variables Self-Esteem
      and Alienation was conducted. It was found that Self-Esteem remained unaffected
      while Alienation levels decreased initially but started rising again a 1-year
      period of participation in the organization. The author hypothesizes reasons for
      these relationships and suggest areas for subsequent investigations.

PMID- 1018100
TI  - Iatrogenic homosexuality: gender identity in seven 46,XX chromosomal females with
      hyperadrenocortical hermaphroditism born with a penis, three reared as boys, four
      reared as girls.
AB  - This paper describes seven chromosomal and gonadal females with the adrenogenital
      syndrome who were born with a penis as a result of extreme fetal androgenization.
      Four of them were reared as girls and differentiated a female gender identity
      with tomboyism. The other three were reared as boys, differentiated a male gender
      identity, and performed sexually as men with women partners. Even though these
      men are by no means homosexual in the everyday meaning of the term, the sexual
      relation is homosexual on the criteria of chromosomal and gonadal sex. The
      prenatal hormonal environment as well as the social experience of the rearing
      have thus demonstrated a formula for creating the perfect female homosexual.

PMID- 1018101
TI  - The use of stimulus/modeling videotapes in assertive training for homosexuals.
AB  - The purpose of this study was to develop and apply an experimental approach for
      teaching assertive behaviors in selective problematic interpersonal situations
      encountered by homosexuals. Specifically, the approach explicates a treatment
      format that combines the use of stimulus/modeling videotapes with behavioral
      rehearsals, videotape feedback, and home assignments. Results of a single-subject
      interrupted time-series analysis suggest that the client displayed significantly
      more assertive behaviors on four of the six criterion measures. The findings
      further suggest that with contextual modification this interventive format can be
      applied to a variety of sexual behavior patterns.

PMID- 1018102
TI  - Code switching and sexual orientation: a test of Bernstein's sociolinguistic
      theory.
AB  - Bernstein's theory was tested in the homosexual's "closed" community to determine
      code-switching ability and its relationship to jargon. Subjects told a story
      based on homoerotic photographs where knowledge of sexual orientation was varied.
      Rather than finding the restricted code associated with in-group communication,
      an analysis of data trends (since all hypotheses were rejected) suggests that
      homosexual hemophyly encouraged elaboration, and status differentiation resulted
      in a more restricted code. Story length was the most significant variable across
      groups. Some of Bernstein's theoretical explanations require modification to
      account for subjects' behavior in stigmatized social groups.

PMID- 1018103
TI  - Forbidden colors of love: patterns of gay love and gay liberation.
AB  - A typology of styles of loving is applied to the search for partners among gay
      males, using a sample of advertisers in a gay newspaper. Characteristics of
      advertisers and of the partners they seek are analyzed. The impact of gay
      liberation ideology on gay male relationships is considered as a model of
      predicted changes in heterosexual male selection patterns.

PMID- 1018104
TI  - Reported consequences of decriminalization of consensual adult homosexuality in
      seven American states.
AB  - This article reports results of a survey of police officials, prosecuting
      attorneys, and members of homosexual groups in the seven states that had
      decriminalized private homosexual behavior between consenting adults. Despite the
      dire predictions of many, the responses indicate that, among other things,
      decriminalization has had no effect on the involvement of homosexuals with
      minors, the use of force by homosexuals, or the amount of private homosexual
      behavior. Additionally, decriminalization reportedly eased somewhat the problems
      of the homosexual community and allowed the police to devote more time to the
      investigation of what generally are regarded as more serious criminal offenses.

PMID- 1018105
TI  - The role of cognitive and situational variables in aggression toward homosexuals.
AB  - The relationship of several antecedents of aggression toward homosexuals was
      investigated. Attitudes toward homosexuality, perceived similarity to the target
      homosexual, and type of prior contact with the target homosexual were found to
      interact in influencing such aggressiveness. The implication of these findings to
      the "personal threat" and "scapegoating" hypotheses of aggression toward
      homosexuals is discussed.

PMID- 1018106
TI  - Sexual aspirations and sexual behaviors among homosexually behaving males and
      females: the impact of the gay community.
AB  - Questionnaires were administered to 100 males and 168 females who expressed
      strong homoerotic aspirations. These two groups were further divided into those
      who were members of the gay community and those who were not. Two questions
      served to focus the research effort: (a) to what extent is the relationship
      between homoerotic sexual aspirations and subsequent gratifications different for
      homosexuality behaving females and males, and (b) what, if any, effect does
      membership in the gay community have on the sexual facilitation of these
      aspirations? Analysis of the data suggests that issues pertaining to differences
      between homosexually behaving males and females cannot be addressed apart from
      corresponding issues concerning the impact of the gay community as a facilitator
      of homoerotic sexual aspirations.

PMID- 1018107
TI  - A factor-analytic conceptualization of attitudes toward male and female
      homosexuals.
AB  - A wide spectrum of opinions and beliefs concerning homosexuals was sampled,
      compiled into a questionnaire format, and administered to a large group of
      heterosexual subjects. Factor analysis yielded six independent sets of attitudes
      that describe the variance in heterosexual reactions to homosexuals. The
      relationship of sex differences and familiarity with homosexuals to variations in
      response style is discussed.

PMID- 1018108
TI  - Homophobia: the quest for a valid scale.
AB  - Using a modified version of Smith's "homophobic scale", this study examines
      attitudinal differences between 60 homosexual and 60 heterosexual Caucasian,
      middle-class males. While Smith's items fail to meet minimal Guttman Scalogram
      requirements, significant attitudinal differences were recorded between groups.
      Furthermore, homosexual subjects were significantly more liberal than
      heterosexual subjects regarding the propriety of masturbation extramarital sexual
      activities, as well as the sexual activities of their teenage sisters. Although
      homosexual subjects evidenced a consistent liberal attitude toward sexual
      behavior in general many heterosexuals indicated a strong margin of attitudinal
      uncertainty in their responses.

PMID- 1018109
TI  - Case management of the gender incongruity syndrome in childhood and adolescence.

PMID- 1018110
TI  - Lesbian/feminist orientation among male-to-female transsexuals.
AB  - Autobiographical case studies of two male-to-female transsexuals reveal a pattern
      of strong female identity couples with lesbian sexual-affectional preference and
      feminist value orientation. For both informants there is evidence of social
      concern and activism from an early age, which led them to perceive their gender
      dilemmas in a political as well as personal way. This case material challenge the
      notion that transsexuals are necessarily "sexualy Uncle Toms" and demonstrated
      that male-to-female transsexuals (like genetic women) can achieve an affirmative
      lesbian identity; it suggests more generally that the development of sexual
      identity is an ongoing, lifelong process.

PMID- 1018111
TI  - Task demand as reflected in catecholamine excretion and heart rate.
AB  - Immediate effects and aftereffects of exposure to a color-word conflict task were
      studied in two groups of subjects, one of which performed the task without
      auditory interference ("single conflict"), the other with auditory interference
      ("double conflict"). Physiological arousal indices were more susceptible than
      performance measures to the level of task demand. Thus, the higher demand imposed
      by the double-conflict task was reflected in relatively larger increases of
      adrenaline excretion and heart rate, both during the conflict task and during the
      subsequent arithmetic task, whereas the performance measures remained unaffected.

PMID- 1018112
TI  - Why do women liver longer than men?
AB  - In the contemporary United States, mortality is 60% higher for males than for
      females. Forty percent of the excess of male mortality is due to arteriosclerotic
      heart disease, which is more common among men in part because they smoke
      cigarettes more than women do, and apparently also because they more often
      develop the competitive, aggressive Coronary Prone Behavior Pattern. Men who do
      not develop this Behavior Pattern may have as low a risk of coronary heart
      disease as comparable women. Oophorectomy of young women may increase the risk of
      coronary heart disease, but administration of female hormones generally does not
      reduce risk. One third of the sex differential in mortality is due to men's
      higher rates of suicide, fatal motor vehicle and other accidents, cirrhosis of
      the liver, respiratory cancers and emphysema. Each of these causes of death is
      linked to behaviours which are encouraged or accepted more in males than in
      females: using guns, drinking alcohol, smoking, working at hazardous jobs, and
      seeming to be fearless. Thus, the behaviors expected of males in our society make
      a major contribution to their elevated mortality.

PMID- 1018113
TI  - Health patterns associated with type A behavior: a managerial population.
AB  - Type A Behavior is a behavioral syndrome found to be related to coronary heart
      disease and characterized by excessive drive, ambition, and competitiveness.
      Managers from 12 different companies were examined for this syndrome and for a
      number of the known risk factors in coronary heart disease (blood pressure,
      cholesterol, triglycerides, uric acid, smoking, and fitness). Those individuals
      exhibiting extreme Type A Behavior (Type A) showed significantly higher blood
      pressure (systolic and diastolic) and higher cholesterol and triglyceride levels.
      A greater percentage of these individuals were cigarette smokers. On serum uric
      acid there were no differences. In each age group, Type A's were less interested
      in exercise, although differences in cardio-respiratory fitness were found only
      in the oldest age group. Type A Behavior also was related to age, education,
      company growth rates, and stress symptoms. Overall, the Type A1's were found to
      be higher on a number of risk factors known to be associated with coronary heart
      disease. With regard to the Type A2's (individuals with less developed Type A
      Behavior), the findings were not conclusive.

PMID- 1018114
TI  - Effect of stress due to anticipated minor surgery upon in vivo platelet
      aggregation in humans.
AB  - When measured just prior to hospital admission, platelet aggregation was faster
      and systolic and diastolic blood pressure were higher compared to measurements
      just prior to surgery and upon discharge fromthe hospital.

PMID- 1018115
TI  - Why do women live longer than men?
AB  - In the contemporary United States, males have 60 percent higher mortality than
      females. In Part I, published in the previous issue, we showed that 40 percent of
      this sex differential in mortality is due to a twofold elevation of
      arteriosclerotic heart disease among men. Major causes of higher rates of
      arteriosclerotic heart disease in men include greater cigarette smoking among
      men; probably a greater prevalence of the competitive, aggressive Coronary Prone
      Behavior Pattern among men; and possibly a protective role of female hormones. In
      addition, men have higher death rates for lung cancer and emphysema, primarily
      because more men smoke cigarettes. In Part II we analyze the other major causes
      of men's higher death rates: accidents, suicide, and cirrhosis of the liver. Each
      of these is related to behaviors which are encouraged or accepted more in men
      than in women in our society--for example, using guns, being adventurous and
      acting unafraid, working at hazardous jobs and drinking alcohol. We conclude with
      suggestions for reducing male mortality; for example, by changing the social
      conditions which foster in men the behaviors that elevate their mortality.

PMID- 1018116
TI  - Stress, illness, and illness behavior.
AB  - This paper examines adaptation as a transactive process involving the skills and
      capacities of individuals and their supporting groups on the one hand, and the
      types of challenges they face on the other. Many difficulties in understanding
      stress processes in illness result from the confusion between illness and illness
      behavior. It is argued that the medical record is as much a history of the
      individual's behavior and social selection processes as it is a reflection of
      levels of physical health. Various examples are discussed, illustrating how
      medical records can be misleading in research examining the relationship between
      stress and illness, and how influences attributed to stress may be the result of
      illness behavior. The paper concludes by examining alternative conceptual models
      for studying the relationships between life challenges, illness behavior and
      illness.

PMID- 1018117
TI  - Temporal uncertainty, anticipation time, and cognitive coping under threat.
AB  - The effects of temporal uncertainty, anticipation time, and coping orientations
      on anticipatory reactions to an inevitable electric shock were investigated. One
      hundred eight male subjects were randomly assigned to the experimental
      conditions: they knew or did not know (temporal uncertainty) exactly when shock
      would occur; they waited either 1, 3, or 12 minutes for the shock, and were given
      either a vigilance, avoidance, or no orientation for preparing for the shock.
      Physiological measures were recorded continuously and pre- and post-trial
      questionnaires were completed to assess thoughts and feelings. Temporal
      uncertainty and anticipation time interacted to affect stress reactivity--i.e.,
      as shock became imminent, temporal uncertainty led to the increased use of
      avoidant (as opposed to vigilant) modes of coping and was associated with a
      progressive lowering of reactivity, especially under the longer anticipation
      times. The results are consistent with the theory that coping processes mediate
      stress reactions under conditions of threat.

PMID- 1018118
TI  - Urban commuting: crowdedness and catecholamine excretion.
AB  - Male passengers regularly commuting by train on the Stockholm-Nynashamn line were
      investigated on two morning trips to Stockholm. These trips were made under
      different levels of crowding, before (Trip 1) and after (Trip 2) a period of gas
      rationing during the oil crisis in 1974. However, seats were available for almost
      everyone during both trips. One group of subjects boarded the train at its first
      stop (Nynashamn), the other midway on its route (Vasterhaninge). Physiological
      reactions were assessed from the rate of catecholamine excretion in urine and
      subjective experiences were measured by self-ratings. The results showed that
      feelings of discomfort grew more intense as the train approached Stockholm and
      the number of passengers increased. Perceived crowdedness increased as the square
      of the number of passengers. During both trips the subjects from Nynashamn
      (longer trip) had a lower rate of adrenaline and noradrenaline excretion on the
      train than those from Vasterhaninge. Furthermore, it was found that the rate of
      adrenaline excretion was higher for both groups during Trip 2, when the train was
      more crowded. The results support previous findings indicating that the stress
      involved in travelling by train varies more with the social and ecological
      conditions of the trip than with its length or duration.

PMID- 1018119
TI  - Underload and overload in working life: outline of a multidisciplinary approach.
AB  - A research project is outlined in which concepts and methods from social
      psychology and psychophysiology are integrated in the study of human adaptation
      to underload and overload related to technically advanced work processes.
      Attempts are made to identify aversive factors in the work process by studying
      acute stress reactions, e.g., catecholamine excretion, in the course of work and
      relating these to long term, negative effects on well-being, job satisfaction and
      health. Data from a pilot study of sawmill workers support the view that machine
      paced work characterized by a short work cycle and lack of control over the work
      process constitutes a threat to health and well being.

PMID- 1018120
TI  - Effects of prolonged stress on coping style in terminal renal failure patients.
AB  - Fifty-nine patients with terminal renal failure and 59 comparison subjects
      matched on age, sex, origin, education and marital status were administered the
      Shanan Sentence Completion Test at the onset of hemodialysis, to test the
      hypothesis that 1) prolonged stress reduces the tendency to cope actively and
      that 2) the extent of reduction would vary according to the patients' background.
      Findings provided massive support for the first hypothesis; in nearly all aspects
      of coping style investigated, hemodialysis patients obtained significantly lower
      scores, indicative of passivity, negative self-perception and of tendencies to
      withdraw by denial from the harsh reality. Findings on the second hypothesis were
      equivocal. Only sex and education showed interaction with illness and coping.
      Women appeared to be more vulnerable than men. The effects of education on coping
      were reduced as a consequence of the illness. Findings are discussed in terms of
      their implications for stress research and for the advancement of preventive
      measures in hemodialysis treatment.

PMID- 1018121
TI  - Life events before myocardial infarction.
AB  - One-hundred and-twenty-one men between the ages of 35 and 65 who had been
      admitted to a Coronary Care Unit were interviewed within a mean of 2.3 days of
      that admission, concerning their experience of certain specified predesignated
      life events in the previous three months before myocardial infarction. Ninety-one
      of them who were proven to have sustained a myocardial infarction were randomly
      matched individually with 91 men from an industrial payroll for sex, age and
      occupational level. Both groups matched, as groups, on marital status and
      household size. Significantly more patients (p less than .01) than comparison
      subjects reported these life events in the three weeks before infarction, whether
      this was experienced acutely or in an anginal setting. Most events were
      apparently independent of patients' or comparison subjects control; these were
      reported significantly more often by patients, both during the entire 12 weeks
      prior to illness (p less than .01) and during the three weeks immediately before
      infarction (p less than .02). Methodological difficulties are delineated which
      hinder credence as to the role of life events before illness.

PMID- 1018122
TI  - Surgery and mortality in peptic perforation.

PMID- 1018123
TI  - Effect of PGF 2 alpha and stress on the ascorbic acid content of rat adrenal
      gland (a histochemical observation).

PMID- 1018124
TI  - Filarial acute abdomen in pregnancy.

PMID- 1018125
TI  - Giant cell tumour of the bone.

PMID- 1018126
TI  - Dubin-Johnson syndrome (Dubin-Johnson-Sprinze disease).

PMID- 1018127
TI  - Surgery and mortality of perforated peptic ulcer.

PMID- 1018128
TI  - Leucorrhoea in perimenopausal women.

PMID- 1018129
TI  - Pulmonary stenosis.

PMID- 1018130
TI  - Percutaneous needle biopsy of lung (new dimensions).

PMID- 1018131
TI  - Profile of central and peripheral nervous system involvement in muscular
      dystrophy.

PMID- 1018132
TI  - Rheumatic heart disease in Pondicherry (a clinical study).

PMID- 1018133
TI  - Comparative trial of co-trimoxazole and tetracycline in the treatment of lower
      respiratory tract infections.

PMID- 1018134
TI  - Under-Five's Clinic and rural India.

PMID- 1018135
TI  - New approaches to the delivery of child care.

PMID- 1018136
TI  - Health care of rural population of 0-5 age group.

PMID- 1018137
TI  - Small-for-dates babies (follow-up study of 107 cases).

PMID- 1018138
TI  - Acute intestinal obstruction (a review of 1020 operated cases).

PMID- 1018139
TI  - Some common skin conditions of the newborn.

PMID- 1018140
TI  - Panhypopituitarism presumably of diabetic origin.

PMID- 1018141
TI  - Endomyocardial fibrosis.

PMID- 1018142
TI  - Profile of rheumatic heart diseases in India.

PMID- 1018143
TI  - Primary nasal neuroblastoma.

PMID- 1018145
TI  - Peritonitis in children.

PMID- 1018144
TI  - Anodontia.

PMID- 1018146
TI  - Peritonitis in children.

PMID- 1018147
TI  - Origin of popliteus muscle in man.

PMID- 1018148
TI  - Plasma non-esterified fatty acids in diabetes mellitus with coronary artery
      disease.

PMID- 1018149
TI  - Paediatric premedication with oral atropine.

PMID- 1018150
TI  - Vogt-Koyanagi syndrome.

PMID- 1018151
TI  - Changing concepts of medical education.

PMID- 1018152
TI  - Recommendations of the II National Conference on Medical Education, March 1976
      (under the auspices of the Indian Medical Association).

PMID- 1018153
TI  - Role of general practitioners in medical education.

PMID- 1018154
TI  - Orthopaedic training in developing countries.

PMID- 1018155
TI  - Barefoot doctors or health auxiliaries: a plan of action.

PMID- 1018156
TI  - Fiberoptic bronchoscopy: experience with 100 consecutive patients.

PMID- 1018157
TI  - Tuberculous infection in New Orleans.

PMID- 1018158
TI  - Stevens-Johnson syndrome: a pediatric experience.

PMID- 1018159
TI  - Mediastinal tumors. IV. Malignant thymoma.

PMID- 1018160
TI  - Heart throbs: fact or artifact?

PMID- 1018161
TI  - Hypersensitivity in the anterior median eye of a jumping spider.
AB  - Changes in sensitivity of the photoreceptor cells of the anterior median eye of
      the jumping spider Menemerus confusus Boes. et Str. have been studied by
      recording electroretinograms (ERGs) and receptor potentials. The amplitudes of
      the responses (ERGs and receptor potentials) increase during repetitive
      stimulation, with a maximum increase at 3-5 s intervals. The sensitivity of the
      photoreceptor cell is greater for about 60 s following illumination (maximum
      magnitude at 3-5 s) than it is during complete dark adaptation. This phenomenon,
      which we call 'hypersensitivity', is lost within one day following surgery in
      physiological saline. Upon loss of hypersensitivity, the sensitivity decrease
      during light adaptation is greater than for the normal eye and the small increase
      of sensitivity following the onset of illumination observed for the normal eye is
      lost.

PMID- 1018162
TI  - The effects of osmotic stress on the electrical properties of the axons of a
      marine osmoconformer (Mala squinado. brachyura: crustacea).
AB  - In contrast to the depolarization observed in hyperosmotic media, exposure of
      peripheral nerve to hyposmotic conditions induced pronounced axonal
      hyperpolarization. It is suggested that this hyperpolarization resulted from
      increased potassium and chloride permeabilities which could assist axonal volume
      regulation in hyposmotic conditions. The hyperpolarization was readily
      reversible, but the spike-generating mechanism suffered irreversible damage at
      hyposmotic concentrations below 665 m-osmoles. It is suggested that this axonal
      damage contributes to the lethal effects of hyposmotic stress in this crustacean
      osmoconformer and, possibly, in some euryhaline osmoregulators.

PMID- 1018163
TI  - Spirillum swimming: theory and observations of propulsion by the flagellar
      bundle.
AB  - The hydrodynamics and energetics of helical swimming by the bacterium Spirillum
      sp. is analysed using observations from medium speed cine photomicrography and
      theory. The photographic records show that the swimming organism's flagellar
      bundles beat in a helical fashion just as other bacterial flagella do. The data
      are analysed according to the rotational resistive theory of Chwang & Wu (1971)
      in a simple-to-use parametric form with the viscous coefficients Cs and Cn
      calculated according to the method of Lighthill (1975). Results of the analysis
      show that Spirillum dissipated biochemical energy in performing work against
      fluid resistance to motion at an average rate of about 6 X 10(-8) dyne cm s-1
      with some 62-72% of the power dissipation due to the non-contractile body. These
      relationships yield a relatively low hydromechanical efficiency which is
      reflected in swimming speeds much smaller than a representative eukaryote. In
      addition the Cn/Cs ratio for the body is shown to lie in the range 0-86-1-51 and
      that for the flagellar bundle in the range 1-46-1-63. The implications of the
      power calculations for the Berg & Anderson (1973) rotating shaft model are
      discussed and it is shown that a rotational resistive theory analysis predicts a
      5-cross bridge M ring for each flagellum of Spirillum.

PMID- 1018164
TI  - Passive exchanges during water vapour absorption in mealworms (Tenebrio molitor):
      a new approach to studying the phenomenon.
AB  - The weights of single mealworms were continuously recorded at 20 degrees C during
      exposure to periods of constant humidity and to abrupt changes in atmospheric
      vapour pressure. Two exchange stages were recognized in each animal. Weight
      changes were either limited to slow losses, suggesting transpiration through the
      external cuticle, or showed more rapid humidity-dependent gains as well as
      losses. Rapid exchanges indicated that water was gained or lost through permeable
      barriers, from a fluid compartmet of significantly lower vapour pressure than the
      haemolymph, equivalent to about 90% R.H. Weight gains and losses during humidity
      changes provided evidence of a significant, passively exchanging fluid
      compartment located between the exchange surface and absorbing mechanism. Weight
      changes in faecal pellets following their elimination provide further support for
      a rectal site of atmospheric absorption.

PMID- 1018165
TI  - Neuronal basis of a sensory analyser, the acridid movement detector system. III.
      Control of response amplitude by tonic lateral inhibition.
AB  - 1. The Lobular Giant Movement Detector neurone (LGMD) of Schistocerca responds
      with spikes when small areas of the visual field change in luminance. Previous
      work has shown that changes of +/- 1 log 10 unit are enough to produce maximal ON
      and OFF responses. 2. Using a 5 degree test area, it is shown that the number of
      spikes generated by such a stimulus depends on the luminance of the surrounding
      area. When the surround is dark, the response is maximal; when it is brightly
      lit, the response is minimal. Intermediate intensities produce intermediate
      values of response. A X 2 change in response is produced by about 3 log 10 units
      change in surround intensity. 3. A bright annulus, with diameters of 10-5 degrees
      and 25-8 degrees, inhibits both ON and OFF responses when concentric with the 5
      degree test area, but not when it is 30 degrees eccentric to the test area. The
      inhibitory effect shows no decrease after 4 min. 4. These results are interpreted
      to indicate a tonic lateral inhibitory network, sited peripherally in the optic
      lobe prior to the divergence of the separate ON and OFF channels found in the
      projection from the medulla to the LGMD. It is probably identical with that
      described for the lamina by previous workers.

PMID- 1018166
TI  - Primitive nervous systems: electrophysiology of the pharynx of the polyclad
      flatworm, Enchiridium punctatum.
AB  - 1. Electrical activity accompanying motor activity can be recorded from the
      excised pharynx of Enchiridium punctatum. Multiple stimuli elicit behaviour which
      consists of an initial aperture closure followed by extension and then
      peristalsis. If the stimulus parameters are increased the preparation bends from
      side to side instead of proceeding through the behavioural sequence. Bending
      appears to inhibit other movements differentially. 2. The conduction involved
      with peristalsis is polarized and proceeds in a proximal direction. 3. With
      stimulus intensities greater than those needed to produce the behavioural
      response an initial muscle potential (IMP) is evoked. The IMP is frequency
      sensitive. Maximum facilitation occurs within 100 ms and drops to 50% of maximum
      within 250 ms. 4. Conduction velocities of the IMP range from 0-05 m s-1 to 1-9 m
      s-1. Conduction velocities appear to increase with facilitation.

PMID- 1018167
TI  - Rhythmic swimming activity in neurones of the isolated nerve cord of the leech.
AB  - 1. Repeating bursts of motor neurone impulses have been recorded from the nerves
      of completely isolated nerve cords of the medicinal leech. The salient features
      of this burst rhythm are similar to those obtained in the semi-intact preparation
      during swimming. Hence the basic swimming rhythm is generated by a central
      oscillator. 2. Quantitative comparisons between the impulse patterns obtained
      from the isolated nerve cord and those obtained from a semi-intact preparation
      show that the variation in both dorsal to ventral motor neurone phasing and burst
      duration with swim cycle period differ in these two preparations. 3. The increase
      of intersegmental delay with period, which is a prominent feature of swimming
      behaviour of the intact animal, is not seen in either the semi-intact or isolated
      cord preparations. 4. In the semi-intact preparation, stretching the body wall or
      depolarizing an inhibitory motor neurone changes the burst duration of excitatory
      motor neurones in the same segment. In the isolated nerve cord, these
      manipulations also change the period of the swim cycle in the entire cord. 5.
      These comparisons suggest that sensory input stabilizes the centrally generated
      swimming rhythm, determines the phasing of the bursts of impulses from dorsal and
      ventral motor neurones, and matches the intersegmental delay to the cycle period
      so as to maintain a constant body shape at all rates of swimming.

PMID- 1018168
TI  - Evidence for calcium inactivation during hormone release in the rat
      neurohypophysis.
AB  - 1. A study has been made of the relationship between 45Ca uptake into and hormone
      release from isolated rat neurohypophyses incubated in vitro. 2. Hormone
      secretion is triggered by high-K (56 mM) but long exposure to the stimulus does
      not generate a maintained release of hormone. 3. When hormone release began to
      wane, addition of Ba of La increased hormone output which suggests that the
      decline in output did not result from depletion of the neurosecretory granules at
      the nerve terminals. 4. 45Ca uptake is enhanced in the presence of high-K
      concentration, but the initial high rate declines during long exposure to the
      potassium stimulus with a time constant similar to that of the decline in hormone
      release. 5. After a period of incubation in a K-rich, calcium-free medium,
      addition of calcium to the medium induced hormone release. The magnitude of this
      release was dependent on the time of exposure to excess potassium. 6. After
      inactivation of secretion, mobilization of internal calcium by means of a calcium
      ionophore increased hormone release.

PMID- 1018169
TI  - Heart action of the freshwater bivalve Anodonta anatina during activity.
AB  - 1. Heart action of Anodonta anatina (L.) was investigated by recording the
      electrocardiogram (ECG), heart impedance, and ventricular and pericardial cavity
      pressure during different aspects of the normal behaviour. The contribution of
      mechanical and nervous mechanisms in controlling changes in heart action is
      discussed. 2. Pressure recordings were generally more reliable than the other
      methods and it is suggested that pericardial pressure pulses indicate the stroke
      volume output of the ventricle. 3. During spontaneous periods of prolonged shell
      closure there was an initial small increase in heart activity followed by a large
      reduction in both heart rate and systolic pressure, indicating that total heart
      output was considerably reduced. When the shell reopened, heart rate increased
      very rapidly with an initial overshoot of the normal level; systolic pressure
      increased more slowly with no overshoot. 4. These major changes in heart activity
      appear to be associated with respiratory changes and are controlled largely by
      the nervous regulatory system, but some minor rhythmic variations in the
      amplitude of heart beat are probably caused by mechanical factors. 5.
      Characteristic patterns of change in heart action were recorded during burrowing.
      These appear to result from haemodynamic changes associated with the muscular
      movements of the digging cycle. Control of the heart by the nervous regulatory
      system is apparently of much greater importance in relation to respiratory
      control than in relation to the haemodynamic functioning of the fluid-muscle
      system in locomotion.

PMID- 1018170
TI  - Modulation of Hydra attenuata rhythmic activity: phase response curve.
AB  - We investigated the effect of photic stimulation on the frequency of Hydra
      attenuata column contractions. We used positive or negative abrupt light
      transitions, single or repetitive light or darkness pulses, and alternation of
      light and darkness periods. The main results are: (a) The frequency of the
      contraction pulse trains (CPTs) varies transiently in response to an abrupt
      variation of the light intensity. (b) CPTs in progress can be inhibited by
      different types of photic stimuli. (c) The response time to a single photic
      stimulus varies during the inter-CPT interval and depends also on the polarity of
      the stimulus. (d) The CPTs are entrainable with repetitive light stimulation of
      various frequencies. (e) Long-lasting variations of the frequency of CPTs occur
      after the end of a repetitive light stimulation. We suggest that the mechanism
      responsible for the rhythym of column contractions is quite similar to that on
      which other biological rhythmic phenomena are based.

PMID- 1018171
TI  - Events following the infections of enucleate cells with measles virus.
AB  - The development of measles virus (Edmonston) and SSPE measles virus (Horta
      Barbosa) has been examined in enucleate BSC 1 cells. New antigen synthesis in
      measles virus infected enucleate cells has been demonstrated by fluorescent
      antibody, by the formation of extensive syncytia from enucleate cells alone and
      by analysis of polypeptide formation by polyacrylamide gel electrophoresis. All
      polypeptides formed in nucleate cells were also present in enucleate cells but
      the amount synthesized was reduced to around 20% of that in nucleate cells. There
      was also a significant reduction in the amount of antigen detected by fluorescent
      antibody in enucleate as compared to nucleate preparations. Examination of RNA
      synthesis in infected enucleate cells revealed only a marginal increase in acid
      insoluble material. Titration of the output of infectious virus from enucleate
      cells infected at both 37 and 31 degrees C indicated a consistent reduction of
      almost two log units compared to nucleate cells. That the enucleate cells were
      capable of replicating input genome at these times was demonstrated by the
      successful growth of respiratory syncytial virus, both at 37 and 31 degrees C.
      SSPE measles virus grew to higher yield in nucleate BSC 1 than measles virus but
      there was again a reduction of more than two log units in enucleate cells. All
      polypeptides synthesized in SSPE infected nucleate cells were apparent in
      enucleate cells.

PMID- 1018172
TI  - Homogenization-resistant and -susceptible components of tobacco mosaic virus
      replicative form RNA.
AB  - When prepared from tissue frozen with liquid nitrogen, tobacco mosaic virus
      replicative form RNA (TMV RF) was uniform in size but when prepared by high-speed
      homogenization, or when TMV RF prepared with liquid nitrogen was homogenized, 80
      to 90% of the RF broke into relatively discrete pieces. The unbroken RF was not
      fragmented by additional homogenization. The TMV RF components susceptible and
      resistant to breakage, respectively, were synthesized with similar kinetics in
      relation to length of labelling period, but the slightly more resistant component
      was synthesized during the early infection period. Both components were produced
      by different strains of TMV but leaves infected with cowpea chlorotic mottle or
      southern bean mosaic viruses yielded only RF resistant to breakage. TMV
      replicative intermediate RNA was also broken by homogenization. The occurrence of
      the two RF components may be of significance in the replication of RNA viruses.

PMID- 1018173
TI  - Ortho- and paramyxoviruses from migrating feral ducks: characterization of a new
      group of influenza A viruses.
AB  - Ortho- and parainfluenza viruses isolated from the cloacas of migrating feral
      ducks shot on the Mississippi flyway included three strains of influenza. A virus
      (Hav6 Nav1, Hav6 Nl, Hav7 Neq2) as well as Newcastle disease virus. One influenza
      virus, A/duck/Memphis/546/74, possessed Hav3 haemagglutinin, but the
      neuraminidase was not inhibited by any of the known influenza reference antisera.
      The neuraminidase on this virus was related to the neuraminidases on
      A/duck/GDR/72 (H2 N?), A/turkey/Ontario/7732/66 (Hav 5 N?), A/duck/Ukraine/1/60
      (Hav3 N?) and A/turkey/Wisconsin/68. We therefore propose that the neuraminidase
      on this group of influenza viruses be designated Nav6. The A/duck/Memphis/546/74
      influenza virus caused an ocular discharge in 1 of 5 ducks and was shed in faeces
      for 10 days; it was stable in faecal samples for up to 3 days at 20 degrees C.
      These results suggest that ecological studies on influenza in avian species
      should include attempts to isolate virus from faeces. Faecal-oral transmission is
      an attractive explanation for the spread of influenza virus from feral birds to
      other animals.

PMID- 1018174
TI  - Xf phage invading the host cells with their protein coats.
AB  - The Xf phage coat protein associated with infected cells could not be removed by
      washing with antiserum and tris-EDTA buffer. Although the infected cells were
      consecutively washed 6 times with tris-EDTA buffer, the ratios of parental phage
      6H-DNA to 14C-protein were not changed. A considerable amount of the parental 14C
      protein and 3H-DNA in the original ratio were detected in the membrane and the
      soluble cytoplasmic fractions of infected cells. The studies of the change in Xf
      14C-protein and 3H-DNA incorporation into the host cells and their release showed
      that DNA and protein penetrate together into the host cells during the first 60
      min after infection (p.i.). While virtually all parental DNA was conserved, re
      utilized and released from the infected cell 60 min p.i., no apparent release of
      parental protein was observed. Approx. 40% of the parental protein became
      degraded and could be washed from the infected cell after 90 min; the rest of the
      parental protein remained and probably was re-utilized by the host.

PMID- 1018175
TI  - On the regulation of protein synthesis in vaccinia virus infected cells.
AB  - All eukaryotic mRNA species show a characteristic individual translational
      efficiency under conditions of restricted polypeptide chain initiation caused by
      an increase in the osmolarity of the growth medium. In vaccinia virus infected L
      cells or HeLa cells virus mRNAs can be grouped into classes on the basis of their
      relative labelling under standard and hypertonic conditions. Under the latter
      conditions, most of the "early" mRNAs possess very high translational
      efficiencies, most of the "intermediate" mRNAs show an intermediate efficiency
      and the most prominent "late" mRNAs show a translational efficiency which is
      lower than that of other virus mRNAs but still higher than the average cellular
      mRNA. Late in the infection cycle virus mRNAs with a relative low translational
      efficiency are preferentially translated under standard growth conditions whereas
      "early" virus mRNAs which are still present and which show a higher translational
      resistance to hypertonic conditions are not translated. These results indicate a
      unique translational control operating late in the growth cycle of vaccinia
      virus.

PMID- 1018176
TI  - A rapid method for the quantitative study of RNA from canine distemper virus
      infected cells.
AB  - Centrifugation through CsCl was used to isolate 32P-labelled RNA in a one-step
      purification procedure. The method is suitable for quantitative as well as
      preparative studies and appears to have considerable advantages over conventional
      methods of RNA extraction. We have used this procedure to investigate the RNA
      synthesized in Vero cells infected with canine distemper virus (CDV). We show
      that the combination of CsCl centrifugation and affinity chromatography on poly-U
      Sepharose provides a rapid method for isolating messenger RNA from virus infected
      cells.

PMID- 1018177
TI  - Inhibition of vaccinia virus growth by the nucleoside analogue 1-beta-D
      ribofuranosyl-1,2,4-triazole-3-carboxamide (virazole, ribavirin).
AB  - Virazole or Ribavirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide)
      inhibits the growth of vaccinia virus at a concentration ode to a certain extent
      in the presence of Virazole, the DNA fails to acquire resistance to
      deoxyribonuclease and virus particles are not formed. Reversibility of the
      antiviral effect occurs when the drug is washed out from the infected cultures or
      when guanosine at an equimolar concentration is added.

PMID- 1018178
TI  - The use of contact B mode ultrasound in pediatric ophthalmology.
AB  - It has been shown that an ultrasound system such as the Bronson-Turner Contact B
      Mode can be added, fruitfully, to the armamentarium of the individual pediatric
      ophthalmologist. It can be used quickly and precisely with an ophthalmological
      training and without patient discomfort or anesthesia no matter what the age.
      Valuable anterior segment information can be readily gained without a waterbath.
      Examples are shown of children with opaque media who were found to have
      congenital cataracts and congenital aphakia, microphthalmos, PHPV, retinal
      anomalies and ectatic coloboma.

PMID- 1018179
TI  - Fascia lata sling in blepharoptosis: enhancement of result by postoperative
      adjustment.

PMID- 1018180
TI  - Rhinosporidiosis in children.

PMID- 1018181
TI  - Freeze-cleaved replicas of the anterior surface of the vitreous body in premature
      infants.
AB  - An electronmicroscopic structure of the anterior vitreous surface of premature
      human infant cadavers at the age of six, seven and eight months demonstrated with
      replica technique is presented. A regular hexagonal structure has been found
      behind the center of the lens. Towards the equator of the lens this structure is
      losing its regularity and may exhibit the forms of pentagons, rectangles, etc.
      This is probably due to the technique applied in the preparation. In one case a
      "mixed type" of fibrillar structure appeared, the arrangement of which does not
      seem to fit into the present concept of the orientation of the collagen fibrils.

PMID- 1018182
TI  - The fusional balancing innervation in heterophoria for control of antipodal
      deviations at a null point: a previously undescribed type of binocular
      innervation.

PMID- 1018183
TI  - Strabismus in children with cerebral palsy.
AB  - A group of 238 patients with cerebral palsy were identified of whom 108 could be
      studied through their charts. Only 20 of these patients had strabismus. Of this
      group, 10 received no surgical therapy. In these patients followed up to a period
      of four years, no evidence of significant change in the strabismic deviation was
      found. Patients who were treated by medical and optical means alone did not show
      evidence of improvement. Surgical therapy was effective in providing a
      cosmetically acceptable result. Surgery was performed between two and one-half
      and 13 years of age in eight patients, with an average age of surgery of 6.5
      years. The results which we obtained are comparable to those obtained by others
      at an earlier age. It does not appear that the age of surgery affects the
      ultimate cosmetic nor functional outcome in children with cerebral palsy.

PMID- 1018184
TI  - Infantile cataracts, Coats' disease, and ketotic hypoglycemia.

PMID- 1018185
TI  - Optic disc pigmentation associated with a field defect following chickenpox.

PMID- 1018186
TI  - Aplasia of the optic nerve.
AB  - A case of unilateral true aplasia of the optic nerve in an otherwise normal and
      healthy child is presented. Twenty-eight previously reported cases of aplasia
      have been reviewed and classified according to criteria which we have presented.
      Only six of these cases, including the present case, represent true aplasia,
      manifested by total blindness and complete absence of the optic disc and retinal
      vessels.

PMID- 1018187
TI  - Recurrence risks for retinoblastoma: a model for autosomal dominant disorders
      with complex inheritance.
AB  - The characteristics of retinoblastoma pertinent to genetic counseling are
      presented. Vogel's model for the inheritance pattern of the tumor is described
      and then used to derive recurrence risks for the important genetic counseling
      situations in retinoblastoma. The effect on the risk of the degree and number of
      unaffected relatives to the index case in a pedigree is quantified.

PMID- 1018188
TI  - Thrombosis of the central retinal artery in retinoblastoma.

PMID- 1018189
TI  - Comparative study of the surgical management of congenital esotropia of 50 prism
      diopter or less.
AB  - Fort-nine patients with congenital esotropia of 50 prism diopters or less were
      selected at random. Twenty-five had bimedial recessions performed initially
      followed by bilateral rectus resections when needed. Twenty-four had
      recession/resections performed initially and when needed, were followed by the
      same procedure on the fellow eye. The average corrections obtained after first
      procedure and after second procedure were compared and analyzed. The results
      showed the initial procedures of both groups to be equally effective. The results
      obtained after the second procedure in the recession/resection group were
      significantly better. Therefore, it would appear that for the patient we have
      described, the most effective surgical approach is ultimately the surgical
      regimen of recession/resection followed by the same procedure on the fellow eye.

PMID- 1018190
TI  - A new approach to the Hirschberg test.
AB  - Forty patients with horizontal strabismus were examined in order to establish a
      correlation between measurements obtained by the alternate cover under the
      amblyoscope and measurements made by passively placing the corneal reflex in
      symmetry of that of the fixating eye. In order to reduce errors, the pupils were
      constricted to two mms and a very intense and bright one mm corneal reflex
      produced. Both measurements were very similar and a correlation of r=0,94 was
      found. Accuracy was significant at the p=0,005 level.

PMID- 1018191
TI  - Clinical picture and management of subperiosteal hematoma of the orbit.
AB  - A subperiosteal hematoma was seen in a 14-year-old boy following a blow to his
      head during a car accident. The involved orbit exhibited exophthalmus and
      inability of the eye to move above the horizontal. X-rays revealed a hairline
      fracture of the skull and a hemotympanum was found on the injured side. A
      subperiosteal hematoma of the orbital roof was suspected. Needle aspiration of
      the blood from the orbital hematoma resulted in an almost immediate cure of all
      orbital and occular problems.

PMID- 1018192
TI  - Hyphema in infancy and childhood: a brief review and report of an unusual case.

PMID- 1018193
TI  - Juvenile glaucoma in the Rubinstein-Taybi syndrome.
AB  - A 10-year-old retarded child was seen by an ophthalmologist because of
      strabismus. Examination of the optic nerve heads revealed cupping consistant with
      glaucoma and initiated a referral. The appearance of this girl, with flat-broad
      based thumbs and toes, small head, low set ears, high arched brows, antimongoloid
      slant to the eyes, high arched palate, associated with mental retardation, and
      strabismus suggested the Rubinstein-Tabyi Syndrome. Gonioscopy revealed a high
      iris insertion, while tonometry indicated mildly elevated pressures in the right
      eye. Examination of the optic nerve heads showed large glaucomatous type cups,
      more so on the right with compromise of the temporal rim. Trabeculectomy was
      effective in controlling the intraocular pressure in the right eye. The
      association of juvenile glaucoma with the Rubinstein-Taybi Syndrome requires that
      ophthalmic referral to assess glaucoma be an essential part of the evaluation.

PMID- 1018194
TI  - Trabeculectomy for adolescent onset glaucoma in the Sturge-Weber syndrome.
AB  - Two patients with adolescent onset glaucoma associated with Sturge-Weber Syndrome
      have been presented. Both patients were successfully treated with ab externo
      trabeculectomy. This procedure is suggested as an additional means for
      controlling the late onset glaucoma associated with the syndrome without
      provoking additional complications or deterioration. Early treatment is
      emphasized before the irreversible changes of chronic glaucoma become manifest.

PMID- 1018195
TI  - Feathered eyebrows and high myopia.

PMID- 1018196
TI  - Enucleations in Nigerian Igbo children.
AB  - A series of 32 eyes enucleated from Nigerian Igbo children has been reviewed.
      Retinoblastoma accounted for 19 enucleations, both sexes being equally affected
      and most growth being far advance. The seven cases of known trauma were with one
      exception encountered in boys and involved mostly plant material. Inflammatory
      pseudotumor was seen in two girls during the first year of life and malignant
      lymphoma in a boy of 15 years. Corneal ulceration was responsible for enucleation
      in three boys, one of them being the aftermath of measles.

PMID- 1018197
TI  - Experimental creeping muscle.
AB  - Using healthy rabbits, medial and lateral rectus muscles were recessed. Classical
      Swann incisions, along with limbal incisions with and without conjunctival
      recession, were performed. The second variable of reactability of suture
      material, utilizing absorbable 6-0 chromic and nonabsorbable 6-0 tycron sutures,
      was tested. Using a 9-0 nylon marking suture for documentation of area of
      recession, anterior advancement could be accurately measured. Five months after
      surgery, the animals were sacrificed, and each muscle was examined. Regardless of
      incision perfored and regardless of suture type used, no anterior advancement of
      retroplaced muscles occurred.

PMID- 1018198
TI  - Pediatric dosing considerations in ophthalmology.
AB  - In almost all cases concerned with topically applied ophthalmic drugs, no
      distinction is made between adults and infants or children with regard to the
      concentration and amount of drug used. Even though maximal therapeutic effects
      are usually observed, there can be significant short- and long-term toxicity
      problems. Based on some modest assumptions it should be possible to reduce doses
      without sacrificing therapeutic effectiveness in infants and children up to three
      years of age. The overriding concern should be, however, potential toxicity
      problems which may exist  in infants and children, in particular the neonate, due
      to their low body weight and the fact that in most cases, more than 90 percent of
      an instilled dose in potentially available to act systemically. Total body
      surface area can be used as a measure for determining potentially toxic doses in
      children. Especially for potent drugs, with both short- and long-term
      manifestations, toxicity considerations may necessitate some sacrifice in
      therapeutic effectiveness of a given drug or switching to an alternate drug in
      order to insure a reduction in toxic side effects.

PMID- 1018199
TI  - Panuveitis -- presenting symptom of systemic sarcoidosis in a child.

PMID- 1018200
TI  - Giant hairy nevus: preventable cause of amblyopia.
AB  - An infant with a congenital giant hairy nevus causing occlusion of the visual
      axis of the right eye is presented. The nevus was removed at the early age of
      three weeks because of concern that the child would develop deprivation
      amblyopia. Since such nevi can undergo malignant changes, early removal may be
      justified for that reason alone.

PMID- 1018201
TI  - Abnormal macular arteriovenous communication.

PMID- 1018202
TI  - The special blood supply of the retina in optic nerve gliomas.

PMID- 1018203
TI  - Ocular pathology of Lowe's syndrome in a female infant.
AB  - The ocular pathologic findings are presented in a case of a female infant with
      clinical and biochemical evidence of Lowe's syndrome. A small but increasing
      number of reports suggest that the mode of inheritance is not always sex-linked.
      The ocular histopathologic findings in the present case parallel those previously
      described for this syndrome. While the pathologic findings in other systems are
      variable, it is thought that the constellation of lens and anterior segment
      changes are sufficiently characteristic to identify cases of Lowe's syndrome.

PMID- 1018204
TI  - Isolated oculomotor nerve palsy in childhood from leptomeningeal polymorphic cell
      sarcoma.

PMID- 1018205
TI  - Atypical vertical retraction syndrome: a case study.
AB  - A case of unilateral retraction of the eyeball in downward gaze as well as
      downshoot with the retraction when an outward horizontal movement of the
      contralateral eye was attempted has been introduced. The case has an exotropia
      with inability to adduct involved eye. The face turned to the left to minimize
      diplopia in the primary position. During the retraction, the lid widened
      slightly. An analyses by electrooculography and electromyography suggested that
      there was an abnormal neural connection between the vertical recti of the
      involved eye and the contralateral lateral rectus muscle. Co-contraction of
      vertical recti and loss of the reciprocal innervation were seen at the involved
      eye. Surgical treatment for exotropia, and total transplantation of vertical
      recti to the insertion of the involved medial rectus resulted in a slight
      reduction of the exotropia with the face straight, but not in the retraction as
      well as adduction and elevation of the involved eye. Based on the results, a
      central mechanism to produce above abnormality was described.

PMID- 1018206
TI  - Electroretinogram and visually evoked cortical potential in Tay-Sachs disease: a
      report of two cases.
AB  - The electroretinogram (ERG) and visually evoked cortical potential (VECP) were
      recorded in two cases of Tay-Sachs disease where diagnosis was well established:
      1. ERGs of high amplitude and of normal wave form were recordable with prominent
      oscillatory potentials. Responses were always equal in both eyes. 2. VECPs were
      extinguished in both cases. These findings were interpreted as showing that Tay
      Sachs disease is caused by the degeneration of ganglion cells in the nervous
      system and that the ganglion cells in the retina do not affect the ERGs of
      vertebrate animals.

PMID- 1018207
TI  - Ectopia lentis with Marfan's syndrome -- case with a useful optical correction.

PMID- 1018208
TI  - Bilateral retinoblastoma and verbal intelligence.
AB  - Sighted and blind patients with bilateral retinoblastoma were compared with their
      unaffected siblings on standardized tests of verbal intelligence. IQs of blind
      subjects were found to be significantly higher than those of their siblings while
      no such difference was noted between sighted subjects and their controls. It was
      concluded that the IQ superiority of the blind group is associated with blindness
      rather than with the disease.

PMID- 1018209
TI  - Recurrent nonaccidentally inflicted chemical eye injuries to siblings.

PMID- 1018210
TI  - Massive congenital ocular toxoplasmosis.

PMID- 1018211
TI  - Embryopathic time-table of cataract formation in congenital rubella.

PMID- 1018212
TI  - Retinoblastoma in an eighteen-year-old male.

PMID- 1018213
TI  - Familial retinoblastoma--a cautionary tale.

PMID- 1018214
TI  - Clinical applications of research in strabismus.

PMID- 1018215
TI  - The cornea in mucolipidosis IV.

PMID- 1018216
TI  - Space occupying orbital lesions in Indian children: a clinical study of 66
      consecutive cases.

PMID- 1018217
TI  - The surgery and results following traumatic cataracts in children.
AB  - Ninety eyes undergoing surgery for the removal of traumatic cataracts have been
      evaluated. In this group, the visual results relate to the coincident
      complications and amblyopia. Most commonly, they may be related to the extent of
      the preoperative trauma to the injured eye or to the age of the patient at the
      time of the injury. Forty-eight eyes (54%) achieved an acuity of 20/20 to 20/80
      with 38 (42%) eyes achieving acuity of 20/20 to 20/30. A visual result of 20/80
      or better was obtained in 12 eyes of the 29 patients six years of age or less.

PMID- 1018218
TI  - Perforating injuries of the eye in childhood.

PMID- 1018219
TI  - Tapeto-retinal degeneration and familial juvenile nephronophthisis (FJN).

PMID- 1018220
TI  - Incidence of retinoblastoma in Malawi.
AB  - The annual incidence of retinoblastoma in Malawi seems to be two cases per
      100,000 children under five or one case per 10,000 live births. A higher
      frequency of one case per 21,700 to 17,900 children under five or one per 4,340
      to 3,580 live births has been found in the Zomba and Mangochi districts.
      Analyzing the cases according to sex and laterality, 61.1 percent of the
      unilateral cases were girls and 58.3 percent of the bilaterals were boys. Among
      boys, 33.3 percent were bilateral while unilateral involvement of the left eye
      was found in 19.1 percent. Among the girls, the frequency of bilateral cases was
      18.5 percent while the unilateral involvement of right and left eye was nearly
      similar.

PMID- 1018221
TI  - The diagnostic significance of worm tracks in cases of pseudoglioma retinae.

PMID- 1018222
TI  - Arachnoiditis and VECP change.
AB  - A five-year-old boy presented with tuberculous meningitis and subsequently
      developed amaurosis with optochiasmatic arachnoiditis (OCA) late in the
      convalescent stage of the illness. The visual evoked cortical potentials were
      correlated with the decreased and improved postoperative acuity. The diagnosis
      and classification of OCA have been discussed with emphasis given to prompt
      neurosurgical treatment.

PMID- 1018223
TI  - Congenital upper eyelid retraction.
AB  - This report describes a six-year-old boy born with a unilateral upper eyelid
      retraction resulting in mild exposure keratopathy. The fissure on that side was 4
      millimeters larger and lagophthalmos was present. At the time of levator
      recession surgery, the muscle was found to have a restriction at the medial and
      lateral horns preventing downward excursion. This condition has some of the
      features of congenital orbital fibrosis and is postulated to have been due to an
      intrauterine infection or inflammation.

PMID- 1018224
TI  - Anomalies of the retinal veins and their incidence.
AB  - Nonaneurysmal anomalies of the retinal veins were studied in 1,400 consecutive
      locally and systemically healthy individuals whose ages ranged from eight to 66
      years. The anomalies included veno-venous crossing, triconfluence, congenital
      dilatation, prepapillary loop, anomalous macular veins, and retinociliary vein.
      Excluding the last three, these anomalies are not at all rare. Hypotheses to
      explain the development of veno-venous crossings and the bifurcation of retinal
      veins are also presented.

PMID- 1018225
TI  - "Tissue-drag" with polyglycolic acid (Dexon) and polyglactin 910 (Vicryl) sutures
      in strabismus surgery.
AB  - The new absorbable synthetic sutures, polyglycolic and (Dexon) and Polyglactin
      910 (Vicryl), are excellent sutures for strabismus surgery, but they have a
      bothersome tendency to attract adjacent tissue (tissue-drag). This difficulty is
      found especially with the 5-0 size suture, less so with the 6-0 size suture, and
      minimally with the 7-0 size suture. The presence and number of short, stubbly,
      protuberant strands (hooklets) seen on the surface of these sutures under high
      magnification correlates with the lack of ease with which the sutures pass
      through tissue. Other factors involved in tissue-drag include the crevices
      between braids in these sutures and the fiber-tissue friction due to the innate
      nature of the suture materials. Sutures which pass with ease through tissue, such
      as catgut and nonabsorbable sutures, are seen to have smooth surfaces under high
      magnification. Coating the 5-0 and 6-0 Dexon and Vicryl sutures to smooth their
      surfaces and reduce tissue-drag was ineffective with isotonic saline solution,
      minimally to moderately effective with glycerine and with methylcellulose and
      polyvinyl alcohol solutions, but highly effective with peanut and sesame oils.
      Though tissue-passage of Dexon and Vicryl sutures was much improved by coating
      with oil and entirely satisfactory, it still was not quite as good as with
      catgut. Clinically, the oil did not compromise the knot security or ease of
      handling of the sutures. No unusual postoperative reaction was seen with the use
      of the oiled sutures. Although oiling the synthetic absorbable sutures at time of
      surgery is effective, we recommend that suture manufacturers reduce the tissue
      drag of synthetic absorbable sutures either by smoothing the surface in the
      manufacturing process or by developing an absorbable coating applied to the
      sutures during manufacture.

PMID- 1018226
TI  - Physiological mediation of attitudinal responses.
AB  - A study was undertaken to try to ascertain the best model of the relationship
      between stimuli, physiological responses, and attitudes. Subjects were asked to
      indicate their attitudes toward various nations after having received various
      bogus information about how they responded physiologically to the stimuli. The
      results indicate the following: (a) In general, attitudes appear to be
      physiologically mediated; (b) physiological mediation of attitudes is strongest
      when prior knowledge about the stimuli is low but is independent of prior
      attitudes about the stimuli; (c) bogus physiological feedback does not seem to be
      verbally mediated; and (d) the most fruitful distinction between types of bogus
      feedback is between any feedback versus no feedback, not between change versus no
      change or between increase versus decrease in response.

PMID- 1018227
TI  - Sex typing and the avoidance of cross-sex behavior.
AB  - This article presents evidence for the hypothesis that cross-sex behavior is
      motivationally problematic for sex-typed individuals and that they actively avoid
      it as a result. In particular, when asked to indicate which of a series of paired
      activities they would prefer to perform for pay while being photographed, sex
      typed subjects were more likely than either androgynous or sex-reversed subjects
      to prefer sex-appropriate activity and to resist sex-inappropriate activity, even
      though such choices cost them money. Moreover, actually engaging in cross-sex
      behavior caused sex-typed subjects to report greater psychological discomfort and
      more negative feelings about themselves.

PMID- 1018228
TI  - Sugars and sugar derivatives which inhibit the short-circuit current of the
      everted small intestine of the rat.
AB  - 1. The short-circuit current of everted rat intestine supported on a perforated
      cannula proved to be stable for up to 3 hr and has been used to study competition
      between transportable and non-transportable sugars. 2. 4,6-O-Ethylidene-alpha-D
      glucopyranose (ethylidene glucose) and 4,6-O-benzylidene-e alpha-D-glucopyranos
      (benzylinene glucose), two nontransportable inhibitors of the hexose transfer
      system in human erythrocytes, were found to reduce the short-circuit current
      generated by transportable sugars such as galactose or 3-O-methyl glucose. 3.
      These compounds were also found to reduce the basal short-circuit current
      established by the everted intestine in a sugar-free Krebs solution. Both types
      of inhibition approached saturation at the higher concentrations used. 4. Similar
      inhibitory properties were shown by mannose, a non-actively accumulated
      monosaccharide, and by the beta-disaccharides lactose and cellobiose. 5. It is
      suggested that this common pattern of behaviour is due to the ability of these
      compounds to react with the sites for active hexose transfer but without
      translocation by the system. The significance of the inhibition of the basal
      short-circuit current is briefly discussed in this context.

PMID- 1018229
TI  - Manganese-dependent propagated action potentials and their depression by
      electrical stimulation in guinea-pig myocardium perfused by sodium-free media.
AB  - 1. Propagated action potentials were recorded in right ventricular papillary
      muscles from guinea-pig heart while exposed to Na-free, Ca-free and Mg-free
      solutions containing Mn. 2. When Na was totally replaced by 95 mM-Mn the
      overshoot was about 45 mV while the resting potential was about -90mV. 3. The
      overshoot of action potentials was increased by about 20-30 mV per tenfold
      increase of Mn concentration over the range of 2-50 mM. 4. Similar increases of
      overshoots with increasing of Mn concentration also occurred in the presence of 0
      6 mM-Ca. Increasing of Ca from 5 to 20 mM had little influence on the overshoot
      but shortened the duration of the Mn-dependent action potential in the presence
      of 5 mM-MN. 5 Mn-dependent action potentials were not depressed by 3 X 10(5) M
      tetrodotoxin but by La. 6. These results suggest that Mn passes through the slow
      inward current channel to generate the action potential seen under the Na-free
      condition. 7. The overshoot and duration of the Mn-dependent action potential
      decreased with stimulation. At stimulus frequencies (Hz) of 0-5, 0-2, 0-1, 0-017
      and 0-0033 the overshoot of action potential in 5 mM-Mn Tyrode decreased by 0-5-1
      mV per an action potential.  This depression of the action potential is explained
      by assuming intracellular accumulation of Mn.

PMID- 1018230
TI  - Afferent sympathetic nerve fibres with aortic endings.
AB  - 1. We recorded the electrical impulse activity of thirty-five single afferent
      fibres with aortic endings isolated from the third to the sixth left thoracic
      sympathetic rami communicantes of anaesthetized cats. The endings of each fibre
      were localized by mechanical probing of the opened aorta at the end of each
      experiment. 2. Twenty-four fibres had a single aortic receptive field. Eleven
      fibres had several and distinct receptive fields (from two to four): they were
      usually located in nearby aortic areas or, in addition, in other proximal
      portions of the arterial tree or in the adjacent pleura and connective tissue. 3.
      Twenty-nine fibres had conduction velocities ranging between 5 and 27 m/sec
      (Group Adelta), while six fibres had conduction velocities between 0-2 and 1
      2m/sec (Group C). 4. The spontaneous impulse activity was in phase with the
      aortic pressure pulse and consisted of not more than one impulse per pressure
      pulse. It was increased during increases in aortic pressure and, conversely,
      decreased during decreases in aortic pressure. In vivo and post mortem studies
      showed that these mechanoreceptors had an impulse activity which rapidly adapted
      during sustained stimuli. They thus seem to signal pulsatile aortic stretch. 5.
      These aortic sympathetic afferents are likely to be part of a nervous pathway
      through which pressor reflexes, exhibiting positive feed-back characteristics,
      can elicited.

PMID- 1018231
TI  - Influence of the sodium pump on intercellular communication in heart fibres:
      effect of intracellular injection of sodium ion on electrical coupling.
AB  - 1. The effect of intracellular sodium injection on the electrical coupling
      between cardiac Purkinje cells was investigated. 2. It was found that an increase
      in the intracellular sodium concentration produces uncoupling in about 500 sec
      and increases the input resistance of the injected cell. Both effects were
      completely reversible. 3. Inhibition of the sodium pump by ouabain (6-8 x 10(7)
      M) also causes electrical uncoupling. 4. The decoupling of heart cells achieved
      by sodium injection was considerably accelerated in fibres treated with ouabain.
      5. The influence of sodium injection on cell communication seems to be related to
      the intracellular calcium concentration 6. The above results indicate that the
      maintenance of a low intracellular sodium concentration by the sodium pump is
      essential for the preservation of a high junctional conductance in cardiac
      fibres.

PMID- 1018232
TI  - The force generated by a visceral smooth muscle.
AB  - 1. Strips of taenia coli from the caecum of the guinea-pig were mounted in an
      organ bath at 37 degrees C; isometric contractions were elicited with 10(5)M
      carbachol. Each taenia was stretched to the length at which it produced the
      maximum active tension; it was then fixed and embedded for measurement of the
      transverse sectional area. 2. The maximal force produced ranged between 96-1 and
      138-3 mN. This corresponded to a force of between 251 and 513 mN.mm(2) (mean: 416
      +/-28 [n = 10]). Temperature changes in the range 23-38 degrees C had little
      effect on the maximal force output.3. When allowance is made for the
      extracellular space (about 32% of the transverse sectional area), for the non
      muscular cells present in the taenia (about 5%), and for the non-contractile
      material present in the muscle cells (about 10%), the maximal force generated was
      about 734 mN.mm(2) of contractile material (or almost twice as large as in
      skeletal muscle).4. Electron microscopy revealed terminal apparatuses at the ends
      of muscle cells, anchoring the cells to the connective tissue, and cell-to-cell
      junctions (attachment plaques). In addition, many dense patches of dense bands,
      sites near the cell surface where filaments are seen to end, were scattered along
      the entire length of the muscle cell and lay close to bundles of collagen
      fibrils. 5. It is suggested that the production of such a large force by this
      smooth muscle is partly explained by the lateral attachment of some contractile
      units to sites along the entire cell length, which in their turn are anchored to
      the collagen network; the latter may be considered a sort of intramuscular
      tendon.

PMID- 1018234
TI  - A simple, inexpensive mechano transducer system using frequence modulation
      [proceedings].

PMID- 1018233
TI  - A superfusion technique for isotope efflux studies and concurrent
      electrophysiological investigation in the rat cuneate nucleus [proceedings].

PMID- 1018235
TI  - A simple and effective ruminal cannulation technique for sheep [proceedings].

PMID- 1018236
TI  - On the acid-induced abolition of reticulo-ruminal motility in sheep
      [proceedings].

PMID- 1018237
TI  - Spatial properties of horizontal cell responses in the turtle retina.
AB  - 1. Intracellular recordings were made from horizontal cells in the retina of the
      turtle Pseudemys scripta elegans. Spatial properties of the responses were
      determined using brief flashes of monochromatic light. 2. For a light stimulus in
      the form of a long narrow slit the peak response decayed approximately
      exponentially with displacement from the centred position. 3. With variation in
      the area of a centred circular patch, the peak response increased in a graded
      manner with stimulus area but was not proportional to area. 4. The model of
      electrical coupling in the horizontal cell layer proposed by Naka & Rushton
      (1976) was applied to the results. For the case of dim illumination a
      simplification is applicable, and the voltage distribution for circular and slit
      shaped patches of light can be expressed in terms of two unknowns: the voltage
      resulting from diffuse illumination and a characteristic 'length constant'. 5.
      The measured variation of response amplitude was well described by the theory.
      Measured length constants were distributed from less than 100 mum to greater than
      1 mm, and in a given cell the values determined by the slit displacement method
      and the area variation method were in reasonable agreement. 6. It is concluded
      that with dim illumination the model provides an accurate description of the
      voltage spread in the cells. Deviations were found to occur at higher intensities
      and possible reasons are discussed. 7. The implications of the model on the
      measurement of resistance changes during illunination are discussed.

PMID- 1018238
TI  - Conjugated and unconjugated pentazocine in the human foeto maternal system and
      neonate [proceedings].

PMID- 1018239
TI  - Collagenolytic activity in peritoneal eosinophils from rats [proceedings].

PMID- 1018240
TI  - The excitatory junction potential in tracheal smooth muscle [proceedings].

PMID- 1018241
TI  - Synaptic properties of identified neurones in the cerebral ganglion of Aplysia
      [proceedings].

PMID- 1018242
TI  - The action of noradrenaline on the smooth muscle of the guinea-pig ureter
      [proceeding].

PMID- 1018243
TI  - Some factors influencing the vulnerability to an induced ventricular arrhythmia
      in the isolated rat heart [proceedings].

PMID- 1018244
TI  - Some observations on abnormal pace-maker activity in endocardial Purkinje fibres
      surviving myocardial infarction [proceeding].

PMID- 1018245
TI  - Effects of modifications of the extracellular potassium concentration on
      excitation-contraction coupling in frog atrial fibres [proceedings].

PMID- 1018246
TI  - Delayed rectification in the skeletal muscle fibre of the crab [proceedings].

PMID- 1018247
TI  - Renal excretion of ammonium and of creatinine: relation to age and to body size
      in the male [proceedings].

PMID- 1018248
TI  - Scorpion venom-induced enzyme secretion in rat pancreatic slices [proceedings].

PMID- 1018249
TI  - The relation between intercellular coupling and electrical noise in turtle
      photoreceptors.
AB  - 1. Intracellular recordings from cones and rods in the retina of the turtle,
      Pseudemys scripta elegans, revealed that in darkness the cell voltage fluctuated
      spontaneously about its mean level. The fluctuations were reduced during bright
      steady illmination of the cell often to a level close to that obtained with the
      electrode outside the cell where the noise did not change significantly during
      illumination. 2. The magnitude of the intrinsic dark noise (voltage variance in
      darkness minus voltage variance in strong light) varied widely from cell to cell.
      In the noisiest cones it was about 0-4 mV2 while in quiet cones it was often as
      low as 0-01 mV2. The noise appeared radom and could be fitted by a Gaussian
      probability density function. 3. The spread of voltage in the network of coupled
      photoreceptors was estimated by measuring the spatial profile of the response to
      a brief flash of constant intensity moved across the retina. For a light stimulus
      in the form of a long narrow slit, the peak flash response usually decayed
      exponentially with displacement from the centred position. 4. For maximum
      responses less than about 5 mV in cones, the length constant of exponential
      decay, lambda, varied from less than 10 mum to greater than 35 mum, and the
      values obtained in opposite directions were often unequal. Background
      illumination did not significantly change lambda. In cells with extremely narrow
      spatial profiles, an exponential fit to the decay could not be made reliably. 5.
      Occasionally the spatial profiles had definite secondary peaks. In the most
      pronounced examples in a red-sensitive cone and in a rod the maxima were
      separated by about 20 and 50 mum respectively; for each, one peak was
      approximately as sharp as the optical stimulator while the second was broader. 6.
      Cones with short length constants displayed high dark noise while cones with long
      length constants were relatively quiet. 7. Three models of electrical coupling
      between cells were investigated: one based on a distributed network, one on a
      discrete square grid arrangement, and one on a discrete hexagonal array. Each
      model predicts a strong dependence of both noise and input resistance on length
      constant, and for tightly coupled cells each predicts that voltage variance is
      proportional to lambda-2. 8. The measured relationship between voltage variance
      and lambda in a large sample of cones was well described by both discrete models
      when the average cell spacing was taken to be approximately 15 mum. 9...

PMID- 1018250
TI  - Post-operative hypoxaemia and oxygen therapy [proceedings].

PMID- 1018251
TI  - Oxygen consumption related to ambient temperature in rats of diffrent thyroid
      status [proceedings].

PMID- 1018252
TI  - Development of thermal stability in the neonate rat [proceedings].

PMID- 1018253
TI  - The effect of age and eye position on the normal ocular microtremor record
      [proceedings].

PMID- 1018254
TI  - Enhancement of a phase of reduced firing in the response of spontaneously active
      cortical neurones to somatic stimulation [proceedings].

PMID- 1018255
TI  - Stretch reflexes in forearm muscles [proceedings].

PMID- 1018256
TI  - Influence of rate of pressure change upon human carotid baroreflex responses
      [proceedings].

PMID- 1018257
TI  - Comparison of the carotid sinus and adjacent common carotid artery, and the
      effects of noradrenaline [proceedings].

PMID- 1018258
TI  - Searching procedure in an ant (Cataglyphis bicolor Fab [proceedings].

PMID- 1018259
TI  - Changes in size and protein turnover of skeletal muscle after immobilization at
      different lengths [proceedings].

PMID- 1018260
TI  - Relationship between physical working capacity and body size and shape of male
      adolescents [proceedings].

PMID- 1018261
TI  - Cardiovascular responses to distenson of the pulmonary arteries in the
      anaesthetized dog [proceedings].

PMID- 1018262
TI  - Histamine and its metabolites in cat portal venous blood and intestine after
      duodenal instillation of histamine [proceedings].

PMID- 1018263
TI  - The sodium-dependent absorption of sugars across the coroid plexus of the sheep
      [proceedings].

PMID- 1018264
TI  - An investigation of the permeability of the rabbit colon [proceedings].

PMID- 1018266
TI  - Epithelial membrane potentials of the epididymis in rats [proceedings].

PMID- 1018265
TI  - The effect of reversed jejunal segments on the myoelectrical activity of the
      small bowel [poceedings].

PMID- 1018267
TI  - The effect of trypsin inhibitors on the in vitro acrosome reaction of guinea-pig
      spermatozoa [proceedings].

PMID- 1018268
TI  - The physiological changes in the vascular supply of the human palcenta - a
      scanning and transmission electron microscopy study [proceedings].

PMID- 1018269
TI  - Chloride transport across sheep and guinea-pig amnion [proceedings].

PMID- 1018270
TI  - Transient inward current underlying arrhythmogenic effects of cardiotonic
      steroids in Purkinje fibres.
AB  - 1. Voltage-clamp experiments were carried out in calf Purkinje fibres to
      determine the basis of transient depolarizations (TDs) associated with digitalis
      induced arrhythmias. 2. Under the influence of strophanthidin, depolarizing clamp
      pulses were followed by a transient inward current (TI) which was small or absent
      in untreated preparations. The TI also appeared in the wake of a train of action
      potentials. 8. The TI can help generate spontaneous depolarizations in
      preparations showing the low voltage oscillations which often occur with advanced
      digitalis toxicity. 8. The TI can help generate spontaneous depolarizations in
      preparations showing the 'low voltage oscillation' which often occur with
      advanced digitais toxicity. It was designated TI because its magnitude and timing
      were appropriate to account for the TD. 3. Longitudinal voltage non-uniformity
      during the TI was determined with two voltage-recording micro-electrodes.
      Although the non-uniformity was not severe, the TI wave form was observed when
      the voltage difference signal was used to measure membrane current density. 4.
      Over the diastolic range of potential, the strophanthidin-induced TI appeared
      superimposed upon the normal pace-maker mechanism, the decay of a potassium
      current, iK2. The TI could be dissociated from iK2, however, by means of its
      unusual kinetic properties. 5. TIs could also be recorded at holding potentials
      positive to -55 mV, i.e. outside the range where iK2 deactivation occurs. 6. The
      TI amplitude showed a slow and strongly sigmoid dependence on the duration of the
      preceding depolarizing pulse. Stronger depolarizing reduced the TI amplitude,
      while slowing and exaggerating the sigmoid time-dependence. 7. Two clamp pulses
      in close succession gave additive effects in evoking a subsequent TI. This
      finding and the sigmoid time-dependence fit with previous observations that TDs
      are most prominent following a series of closely spaced action potentials.

PMID- 1018271
TI  - On the analysis of nerve signals deduced from metacontrast experiments with human
      observers.
AB  - 1. This paper reviews Alpern, Rushton & Torii's (1970a-d) derivation of the size
      of the inhibitory nerve signal arising from after flashes in the metacontrast
      experiment. 2. Their geometric argument is recast in terms of simple functional
      equations. This form of argument clearly displays the role of their assumptions
      in obtaining their main conclusion: nerve signal is linear in intensity over a
      range of 3-4 log units. 3. Two disadvantages of their approach are discussed.
      First, it is noted that in the presence of the data the assumption they employ in
      their analysis is logically equivalent to their conclusion. 4. Secondly,
      accepting their claim that the nerve signal generated by the after flash is
      linear over a broad range of intensities, and that this inhibitory signal simply
      cancels the excitatory signal of the test flash, leads to the conslusion that
      over this same intensity range the excitatory nerve signal is a power function
      with an exponent of close to two. This is incompatible with the suggestion that
      photoreceptor signals have been measured.

PMID- 1018272
TI  - Circadian and other rhythmic activity of neurones in the ventromedial nuclei and
      lateral hypothalamic area.
AB  - 1. The frequency of firing was simultaneously recorded from single neurones of
      the ventromedial nuclei (VMN) and the lateral hypothalamic area (LHA) in urethane
      anaesthetized rats for many hours. 2. There were circadian changes of VMN and LHA
      neurone activity. The pattern of this circadian rhythm is as follows: throughout
      the day LHA neurones show higher activity than that of VMN, as indicated by
      higher frequency and more fluctuations in their rates of firing. In late
      afternoon the discharge rate of LHA neurones increases further, showing
      oscillations of short duration. In the early evening hours LHA neurone activity
      gradually goes down, as the VMN neurones become active. Throughout the night, VMN
      neurones are more active than those of LHA, just the opposite of the day period.
      In early morning hours VMN neurones gradually become quiet, while LHA neurones
      begin to show activity. 3. Superimposed on the circadian rhythm, at certain
      periods of the day, VMN and LHA neurones showed short duration oscillations in
      rate of firing, roughly every 7-15 sec and every 3-5 min. 4. Activities in
      neurones of the VMN and LHA were reciprocally related; a decrease in firing rate
      of one was associated with an increase in the other. This phenomenon was shown
      clearly by analysis of auto- and cross-correlation functions of firing patterns
      of VMN and LHA neurones. 5. The effects of stimulations of the prefrontal cortex
      and splanchnic afferents on VMN and LHA neurones depended on the basic firing
      frequency, thus they varied with the time of day. Definite relationships exist
      between basic firing frequency of a cell and the magnitude of changes evoked by
      these stimuli. Reactions of VMN and LHA neurones were the opposite in most
      instances. Septal stimulations (at more than 10/sec) always produced inhibition
      of LHA neurone activity. 6. Intravenous injection of glucose inhibited LHA
      neurones and accelerated firing of VMN cells. This was true during the day period
      as well as at night when background activities of VMN and LHA neurones were
      different from that of the day. 7. Stimulation of the septal area with
      subthreshold pulses at a low rate (1-0.3/sec) suppressed or altered oscillations
      in firing frequency of LHA neurones. Severance of connection between LHA and
      structures caudal thereto had no effect on LHA neurone firing rates or rhythms.
      Sections between the septal area and LHA, however, abolished or greatly altered
      the oscillatory rhythms of LHA cell activity, although spontaneous discharges
      continued at a somewhat lower rate for periods of hours. 8. Stimulation of
      suprachiasmatic nuclei with weak intensity and low frequency also changed
      oscillatory fluctuations in firing of LHA neurones. 9. Possible origins of
      circadian rhythm and oscillations of short duration in firing pattern of VMN and
      LHA neurones were discussed.

PMID- 1018273
TI  - Short-term synchronization of intercostal motoneurone activity.
AB  - 1. The hypothesis is advanced that the joint occurrence of unitary excitatory
      post-synaptic potentials e.p.s.p.s) evoked in motoneurones by branches of common
      stem pre-synaptic fibres causes short-term synchronization of their discharge
      during the rising phases of the unitary e.p.s.p.s. 2. This hypothesis was tested
      using the pre- and post-stimulus time (PPST) histogram to detect synchronized
      firing among groups of intercostal motoneurones discharging in response to their
      natural synaptic drives. 3. Motor nerve action potentials were recorded
      monophasically from nerve filaments of the external intercostal muscles of
      anaesthetized, paralysed cats maintained on artificial ventilation. 4. Computer
      methods were used to measure peak spike amplitude, spike amplitude, spike
      interval and filament identification for simultaneous recordings from four
      filaments. The spike amplitude histograms were derived for each filament and
      groups of spikes were selected for analysis. 5. With spikes of one group
      designated as 'stimuli' (occurring at zero time) and those of a second as
      'response' the PPST histogram was computed with different time bin widths. 6.
      With bin widths of 100 and 10 msec the central respiratory periodicity was
      apparent in the PPST histogram. With 1.0 msec bins the PPST histogram showed a
      narrow central peak extending to +/- 3.0 msec at its base. This 'short-term
      synchronization' supports the hypothesis of joint firing due to common
      presynaptic connectivity. 7. It was shown that detection of short-term
      synchronization was critically dependent on a sufficient quantity of data but
      that provided a simple criterion of adequate counts per bin in the PPST histogram
      was met, short-term synchronization could be detected between intercostal
      motoneurones of the same and adjacent segments.

PMID- 1018274
TI  - Action potentials in the rat chromaffin cell and effects of acetylcholine.
AB  - 1. Electrophysiological properties of the rat chromaffin cell were studied using
      intracellular recording techniques. 2. The resting potential in the chromaffin
      cell was -49 +/- 6 mV (mean +/- S.D., n = 14) in standard saline containing 10 mM
      Ca whereas that in Na-free saline was -63 +/- 9 mV (n = 17). At rest, the
      membrane has a substantial Na permeability. 3. Action potentials were evoked by
      passing current through the recording electrode. In standard saline the major
      fraction of the action potential disappeared either upon omission of external Na
      ions from standard saline or addition of 1 muM tetrodotoxin (TTX). We conclude
      that action potentials in the chromaffin cell are due mainly to an increase in
      the permeability of the membrane to Na ions. 4. Small but significant
      regenerative action potentials were observed in Na-free saline, and when Ca in Na
      free saline was replaced by Ba, prolonged action potentials occurred. We conclude
      that action potentials in the chromaffin cell also have a Ca component. 5.
      Iontophoretic application of acetylcholine (ACh) produced a transient membrane
      depolarization in standard saline. 6. Spontaneous action potentials were recorded
      extracellularly by microsuction electrodes. They occurred at a rate of 0-05-0
      1/sec in almost all cells. 7. When the perfusion fluid contained 3 x 10(-7) M to
      10(-4) M ACh the spike frequency increased up to about 2/sec. This stimulatory
      effect of ACh was blocked by 10(-7) M atropine but not by 10(-3) M hexamethonium
      nor by 10(-5) M-d-tubocurarine. 8. The importance of Ca entry during action
      potentials for catecholamine secretion is discussed

PMID- 1018275
TI  - Behaviour and aeration of the respiratory system in the domestic fowl embryo.
AB  - 1. The monitoring of developmental stage and under-water dissection were used to
      examine the initial aeration of the respiratory system in domestic fowl embryos.
      2. A virtually complete absence of free air within the chorioallantois was found
      before the beak had begun to make 'beak-clapping' movements, even when the
      membranes were already draped over its tip. 3. During the 'beak-clapping' stage,
      but before the membranes were pierced and before respiratory movements had begun,
      many embryos were found to contain free bubbles of air within the trachea and air
      sacs. 4. All embryos in which the respiratory system was aerated were found also
      to have froth in the crop or other parts of the digestive system. 5. Air was
      found in both the respiratory and digestive systems of all embryos examined after
      membrane penetration by the beak. 6. When air was injected into the
      chorioallantois before the stage of initial aeration it was recovered 5 min later
      from both the respiratory and digestive systems in under-water dissections. 7. It
      is suggested that lung ventilation takes place in the avian embryo in three
      distinct stages: the major air-ways become aerated, then respiratory movements
      begin and lastly the tertiary bronchi are slowly aerated. It is suggested also
      that movements involved in the imbibing of fluids play a part in aeration before
      the membranes are pierced.

PMID- 1018276
TI  - Physiological properties and receptive fields of mechanosensory neurones in the
      head ganglion of the leech: comparison with homologous cells in segmental
      ganglia.
AB  - A study of the head ganglion of the leech was made to compare the properties of
      specific sensory cells in this ganglion with those of homologous neurones in the
      segmental ganglia. 1. In the head ganglion, cells were identified that had
      electrical properties, sensory modalities and adaptation properties similar to
      those of touch (T), pressure (P) and nociceptive (N) cells in the segmental
      ganglia. The cell bodies of these neurones were situated in characteristics
      positions that could be correlated with those in the segmental ganglia. Several
      lines of evidence suggested that they were primary sensory neurones. Fewer T, P
      and N neurones were identified in the head ganglion than would be expected from
      its six constituent segmental ganglia. 2. The receptive fields of identified T, P
      and N cells were situated on the external surface of the head and the interior of
      the mouth with considerable overlap. They were generally smaller in size than
      those situated on the main part of the body. The receptive fields were also
      displaced anteriorly so that some of them were situated in segments anterior to
      those of the innervating cells. 3. The morphology of the sensory cells in the
      head ganglion was studied by intracellular injection of horseradish perioxidase.
      The general branching characteristics of the cells and the structural appearance
      of their processes resembled those of homologous cells in the segmental ganglia.
      However, the routes taken to the periphery by some of the cells were not constant
      from head ganglion to head ganglion. This variability was confirmed by
      electrophysiological evidence, and differed from the constancy seen in segmental
      sensory cells.

PMID- 1018277
TI  - Receptive fields, geometry and conduction block of sensory neurones in the
      central nervous system of the leech.
AB  - 1. In segmental ganglia of the leech, the cutaneous mechanosensory neurones
      responding to to touch innervated the skin of their own segment and of part of
      the anterior and posterior adjacent segments. Each touch receptive field could be
      divided into three non-overlapping areas: a central part innervated by the
      branches of the cell which ran in the nerve roots of the ganglion containing the
      cell body, and anterior and posterior parts innervated by its branches which ran
      in the nerve roots of the anterior and posterior adjacent ganglia. 2. Impulses
      originating from the anterior and posterior parts of the receptive fields were
      susceptible to conduction block within the central nervous system when the touch
      cells fired repetitively at frequencies that could readily be elicited with weak
      mechanical stimulation. In contrast, impulses originating from the central part
      of the receptive fields were less susceptible to block. 3. The morphology of
      touch cells revealed by intracellular injection of horseradish peroxidase
      suggested that conduction block occurred at specific bifurcation points where
      small cell processes joined the main process. Different physiological experiments
      supported this conclusion. 4. In some touch cells, bifurcation points with
      particularly low safety margins of conduction operated as low-pass filters,
      limiting the frequency of impulses capable of invading certain branches. 5. The
      results suggest that mechanical stimuli which would likely be encountered by the
      animal can lead to conduction block within its central nervous system and as a
      result modify its integrative activities.

PMID- 1018278
TI  - The thermal sensitivity of the polymodal nociceptors in the monkey.
AB  - 1. The static and dynamic sensitivities to thermal and mechanical stimuli of
      polymodal nociceptors in hairy skin of the anaesthetized monkey have been
      investigated by recording activity in their primary nerve fibres. 2. Polymodal
      nociceptors responded to skin pricking, pinching and heating to temperatures
      higher than 40 degrees C. They did not respond to touch, stretch or cold. The
      conduction velocity of their axons was from 0.6 to 1.1 m/sec. 3. Three types of
      cutaneous receptive fields have been observed: single spot-like areas of 1-2 mm2;
      multiple spot-like areas of 1-2 mm2; and larger areas up to 25 mm2 with
      heterogeneous sensitivity. 4. Polymodal nociceptors were subjected to heat
      stimuli that commenced from a 33 or 37 degrees C adapting temperature. A series
      consisted of heating their receptive fields to 43, 45, 47 and 50 degrees C from
      one or the other adapting temperatures at a constant rate of 0.2 degrees C/sec.
      Each heat stimulus intensity was maintained for 4 min after which the skin was
      returned to the adapting temperature. Immediately after the first series the
      identical series was repeated in order to determine the effect of prior heating
      upon the dynamic responses to re-heating. The dynamic responses were
      characterized by three phases: an initiation of a discharge at a threshold level
      of skin temperature; a dynamic discharge during the suprathreshold change, that
      reached a peak frequency when the temperature reached its maximum; and an
      adaptation phase while the temperature remained at the high intensity. Adaptation
      was rapid initially, and then slowed during the final minutes at the high
      intensity. 5. Adapting the receptive field to either 33 degrees C or to 37
      degrees C before the heat stimuli did not affect the sensitivity and the
      discharge pattern of the polymodal nocicpetors. 6. During the first series of
      stimulations, the threshold at which the individual polymodal nociceptors began
      to discharge to heat stimuli varied from 40 to 46.5 degrees C. The mean threshold
      of the population was 42.5 degrees C. 7. No change in the threshold was observed
      when responses to 0.2 and 1.5 degrees C/sec rates of heating were compared...

PMID- 1018279
TI  - Predictors of pain during prepared childbirth.

PMID- 1018280
TI  - Headache and personality.

PMID- 1018281
TI  - Heart rate and sleep latency in young men.

PMID- 1018282
TI  - Microvibration and autonomic functions.

PMID- 1018283
TI  - Scaling the seriousness of illness: a methodological study.

PMID- 1018284
TI  - Body image--an apparatus for measuring disturbances in estimation of size and
      shape.

PMID- 1018285
TI  - Nocturnal hormonal profiles in massive obesity, anorexia nervosa and normal
      females.

PMID- 1018286
TI  - A possible relationship between anxiety in pregnancy and puerperal depression.

PMID- 1018287
TI  - Creative dramatics: an outlet for mental handicaps.

PMID- 1018289
TI  - Violence to the spirit of independence.

PMID- 1018288
TI  - Avocational evaluation and work adjustment: a deterrent to dependency.

PMID- 1018290
TI  - Finger replant patient undergoing rehabilitation.

PMID- 1018291
TI  - Live mass gains and wool production of merino sheep: three treatment programmes
      for parasite control.
AB  - A trial is described comparing the live mass gains and wool production of three
      groups of Merino sheep treated either at four-weekly intervals, strategically or
      not at all for the control of helminths and Oestrus ovis during a 19 month
      period. The group treated at four-weekly intervals had the greatest gain in
      masass was not greater than that of the group treated strategically. At both
      shearings the four-weekly treated group produced more wool than did the
      strategically treated group. The latter group produced more wool in total than
      did the untreated group. The seasonal incidence of nematodes, cestodes and
      Oestrus ovis on the trial farm was determined by the slaughter of tracer lambs at
      regular intervals.

PMID- 1018292
TI  - Immunization against coccidiosis in fowls.
AB  - Immunity plays a major role in the control of coccidiosis. With the presently
      practised system of "protected exposure" under chemoprophylactic medication,
      problems are encountered because of seasonal variation in litter moisture and
      coccidial challenge. The alternative, "controlled exposure" or "vaccination"
      products a more solid immunity and more reliable results. This was found to be
      the method of choice in coccidiosis control in replacement pullets in the semi
      arid subtropical climate of Rhodesia.

PMID- 1018293
TI  - Subclinical septic bovine mastitis: critical evaluation of intramammary
      immunoglobulin therapy.
AB  - A series of 152 quarters affected with subclinical staphylococcal and
      streptococcal mastitis was treated at random by intramammary infusion with one of
      4 formulations containing inert solvent, specially prepared immunoglobulin (Ig)
      and antibiotics (penicillin G and streptomycin) in various combinations. The
      effect of treatment was measured by assessing the conversion of mastitic quarters
      to a normal or mastitis-negative state over a post-treatment period of 28 days.
      Considering the solvent as a placebo, solvent plus Ig had no significantly better
      effect than solvent only; solvent plus antibiotics gave results that were highly
      significant after 14 days even though about a third of the strains of S. aureus
      were resistant in vitro to one or both of the antibiotics; solvent plus
      antibiotics and Ig gave results that were highly significant during the whole 4
      weeks after treatment. The Ig solution appeared to be considerably more effective
      against staphylococcal than streptococcal mastitis, but the small numbers
      precluded statistical analyses. It was concluded that use of the particular batch
      of Ig alone had no value in the treatment of the common forms of subclinical
      bacterial mastitis but that in combination with antibiotics the Ig had a somewhat
      better effect than was obtained with antibiotics alone.

PMID- 1018294
TI  - The comparative incidence of subclinical bacterial bovine mastitis in 17 herds
      when using two sets of diagnostic criteria.
AB  - On the single examination of 6804 quarter milk samples during a routine mastitis
      survey in 17 herds it was found that whereas 12,4% of quarters were diagnosed as
      subclinically mastitic when using the IDF standard set of diagnostic criteria,
      only 2,4% were positive when applying the additional criterium of a positive test
      for bovine serum albumin. The remaining 10% of quarters were then classified as
      being affected with septic inflammation of the ducts. The ratio of true
      subclinical septic mastitis to duct and test canal infections is recorded and the
      implications of the findings are briefly discussed.

PMID- 1018295
TI  - Canine systemic lupus erythematosus. The disease, clinical manifestations and
      treatment.
AB  - The similarities between human and canine systemic lupus erythematosus are
      enumerated, using the incidence of symptoms reported for man as a guide to the
      possible incidence of clinical signs in the dog. Differences between the human
      and canine diseases are listed. Four clinical cases of the disease are reported.
      Diagnostic procedures were confined to the observation of clinical signs and
      serological and haematological methods.

PMID- 1018296
TI  - The blood grouping systems of dogs.

PMID- 1018297
TI  - The determination of plasma bicarbonate levels as an aid in the treatment of
      canine biliary fever.

PMID- 1018298
TI  - Canine tetanus.
AB  - A report of tetanus in a dog is presented. The symptoms were typical and the dog
      was successfully treated. The differential diagnoses and the therapy of tetanus
      are discussed with emphasis on the dose of antitoxin required.

PMID- 1018299
TI  - [The problem of people and their pets].

PMID- 1018300
TI  - A search for linkage in cystic fibrosis.
AB  - Linkage between the locus for cystic fibrosis and other genetic markers was
      explored in 40 families from Birmingham and 20 from Manchester. No strong
      evidence was found for linkage with any of the markers examined. There was
      evidence against close linkage with ABO, HLA, and Rh.

PMID- 1018301
TI  - A family study of coarctation of the aorta.
AB  - Families of 100 patients with coarctation of the aorta and 50 controls for age,
      sex, and social status were studied to assess the influence of genetic and
      environmental variables in the aetiology. A tendency to familial aggregation of
      the condition and other congenital heart defects compatible with multifactorial
      inheritance was discerned. Recurrence risk for sibs is approximately 1 in 200 for
      coarctation of the aorta, and 1% for any form of congenital heart defect. The
      heritability of coarctation is estimated at 58%. The tendency for other non
      cardiac defects to occur in the patients with coarctation does not appear in
      their sibs and is not so pronounced as in some other congenital heart conditions.
      Of the several environmental variables examined, there was no definitive
      association with any other than season of birth, which implies a possible
      association with maternal infection; there is also a suggestion of a paternal age
      effect, but these require investigation in a prospective survey.

PMID- 1018302
TI  - Infantile cystinosis in France: genetics, incidence, geographic distribution.
AB  - A national distribution of 66 French patients, from 49 sibships, has been
      studied. Segregation analysis, using the maximum likelihood method, was found to
      agree with the theoretical values expected in recessive autosomal inheritance.
      The birthplaces of these patients show an unequal geographic distribution of
      cystinosis, the incidence being higher in Western France. Compared with the total
      number of live births during the period 1959 to 1972, the minimum incidence of
      the condition in the province of Brittany is 1 per 25 909, and the gene frequency
      0.0062. In the rest of France, the minimum incidence is 1 per 326,440 and the
      gene frequency 0.0018. Application of Dahlberg's formula gives a similar result.
      The mean inbreeding coefficient is 530 X 10(-5), a figure 23 times higher than
      the mean coefficient of France. An indirect test of inbreeding, the distance
      between parental birthplaces, was studied, first using the French administrative
      boundaries, second by using kilometers. This distance was constantly smaller for
      the parents of patients than for the parents of controls. Analysis of two
      erythrocyte polymorphisms (ABO and Rh) showed a large excess of group A patients
      when compared with overall French data. These findings are difficult to interpret
      on genetic grounds. The genetic reasons for the unequal geographic distribution
      of cystinosis in France are discussed.

PMID- 1018303
TI  - Pyloric stenosis in the Oxford Record Linkage Study area.
AB  - The files of the Oxford Record Linkage Study were employed to identify 220
      infants presenting with infantile hypertrophic pyloric stenosis (IHPS) in the 6
      year period 1966 to 1971. Information on these infants was obtained from birth
      certificates and maternity notes. The overall incidence was 2.5 per 1000
      livebirths. There was a distinct seasonal variation, with highest incidence to
      infants born in the third quarter of the year as well as variation in incidence
      with area: the cities had much lower rates of IHPS than the adjacent rural or
      small urban areas. It was shown that the rates in the south and east of the area
      studied were far greater than in the north and west. In the present study there
      was no excess of primiparae, the peak maternal age group was 20 to 24; there was
      a slight excess of parents of social classes I and II; and a significant
      association with mothers who were Rhesus negative. The rate of IHPS among sibs
      was 85 per 1000. Though there was the usual correlation with the male sex (M:F
      ratio = 5.5:1), there was no variation with birthweight and only among the
      females was an association found with prolonged gestation. There appeared to be
      an inverse relation between gestation and age on admission to hospital.

PMID- 1018304
TI  - Lowe's syndrome: identification of carriers by lens examination.
AB  - Lens examinations were performed on 7 obligate and 7 possible carriers of the X
      linked gene for Lowe's syndrome, and on 117 controls. By quantitatively grading
      punctate cortical opacities, it was possible to discriminate between the obligate
      carriers and the controls with a fair degree of confidence. In the age group most
      important for genetic counselling, that of child bearing, the data are too
      limited for the derivation of precise estimates, but may, nevertheless, be
      useful. More such data are needed.

PMID- 1018305
TI  - Congenital scalp defects with distal limb anomalies: report of a family.

PMID- 1018306
TI  - Hereditary index finger polydactyly: phenotypic, radiological, dermatoglyphic,
      and genetic findings in a large family.
AB  - Index finger polydactyly in a Turkish family is reported. The transmission of the
      malformation fits the pattern of regular autosomal dominant inheritance. Some of
      the affected individuals had one or two phalanges on their first digits, but all
      had triphalangeal second fingers. Subjects with polydactyly had very interesting
      dermatoglyphs, such as an extra a triradius under the super-numerary index
      finger, the proximal radiant of this triradius (an extra A-line) ending on the
      radial border of the hand, and arch tibials in the hallucal areas. The carpal
      bones, beginning with os multangulum majus, or alternatively with the extra one
      were articulated with two metacarpals. A similar finding was found in the feet.

PMID- 1018307
TI  - Haemoglobin E Saskatoon beta 22 Glu replaced by Lys in the Shetland Islands.
AB  - A survey of blood samples from the inhabitants of the Shetland Islands has
      revealed the presence of a variant haemoglobin in 1 individual out of the 345
      tested. The rariant haemoglobin accounted for 46% of the total haemoglobin.
      Tryptic digestion and amino acid analysis indicated that the variant haemoglobin
      was caused by the substitution of a glutamic acid residue at position 22 in the
      beta chain by a lysine residue. This is the same amino acid substituion as found
      in haemoglobin E Saskatoon.

PMID- 1018308
TI  - Dicentric X isochromosomes in man.
AB  - Four cases of Turner's syndrome are presented in which an apparent X
      isochromosome i(Xq) has been found to possess two regions of centromeric
      heterochromatin. It is suggested that these chromosomes were isodicentric
      structures capable of functioning as monocentric elements as a result of the
      inactivation of one centromere. The prevalence of mosaicism is believed to be a
      consequence of the dicentric nature of these chromosomes, and it is considered
      possible that a high proportion of X isochromosmes are structurally dicentric.
      Banding patterns showed that the exchange site involved in the formation of the
      dicentric chromosome was different in at least three of the cases.

PMID- 1018309
TI  - Severe mental retardation in a boy with partial trisomy 10q and partial monosomy
      2q.
AB  - A severely mentally subnormal child with many physical stigmata was shown to have
      the karyotype 46,XY,-2,+der(2),t(2;10)(q31;q24)pat. Full evaluation of this
      patient's karyotype depended on the family studies. It was shown that a balanced
      translocation t(2,10) was present in 4 normal males in 3 generations.

PMID- 1018310
TI  - Atypical serum cholinesterase in a family with congenital distichiasis.
AB  - This paper describes the coexistence of genetically determined reduced
      cholinesterase activity and congenital distichiasis in the same family. The
      pedigree suggests that these two autosomal dominant diseases are segregated
      independently and do not show evidence of linkage.

PMID- 1018311
TI  - Triple X female and Turner's syndrome offspring.
AB  - A mentally retarded young female having 47 chromosomes with a triple X karotype
      produced a child with Turner's syndrome associated with mental defeciency. To our
      knowledge this is the first example of a triple X female giving birth to a child
      with Turner's syndrome.

PMID- 1018312
TI  - Renal function studies in an infant with 4p (-) syndrome.
AB  - An infant with the syndrome of deletion of the short arm of chromosome 4 is
      described. In addition, this child had renal insufficiency, which is found rarely
      in association with the 4p(--) syndrome. Previous reports of this syndrome have
      described only isolated gross structural abnormalites of the urinary tract. In
      the case discussed here, we present clinical and functional data which indicate
      that this patient had bilateral renal dysplasia.

PMID- 1018313
TI  - A case of partial trisomy 3q.

PMID- 1018314
TI  - A case of ring chromosome.
AB  - A girl with a G22 ring chromosome is described. There are few physical
      abnormalities, performance quotient is in the low normal range but verbal skills
      are much retarded.

PMID- 1018315
TI  - Familial Ebstein's anomaly.
AB  - A family is described in which both a father and son are affected with Ebstein's
      anomaly, while several other family members manifest different cardiac
      malformations. Five additional instances of familial Ebstein's anomaly were found
      in the literature and compared with our family. Inspection of possible modes of
      inheritance in this group of families suggests that Ebstein's anomaly is probably
      inherited as a polygenic character with a threshold phenomenon.

PMID- 1018316
TI  - Partial trisomy D: a diagnostic and cytogenetic dilemma.
AB  - An 18-month-old proposita with psychomotor retardation and other congenital
      abnormalities is presented. Chromosomal analysis of both parents proved normal.
      However, the karyotype of the proposita contained 47 chromosomes in both
      lymphocytes and cultured fibroblasts. The marker chromosome proved to be a
      deleted No. 14 or 15. Comparison of the reported cases of partial trisomy D
      indicates that a definitive clinical syndrome is not apparent in either case.

PMID- 1018317
TI  - Larsen syndrome in two generations of an Italian family.
AB  - This paper describes a familial case of Larsen syndrome. Typical anomalies were
      present in the propositus and 2 of his 6 daughters. In addition, all patients had
      progressive deafness and the 2 daughters had cleft palate. The certain exclusion
      of any consanguinity between the couple, suggests, in this instance, the dominant
      mode of transmission of the syndrome.

PMID- 1018318
TI  - Self-assembly of bovine epidermal keratin filaments in vitro.

PMID- 1018319
TI  - RNA synthesis in plant leaf tissue: the characterization of messenger RNA species
      lacking and containing polyadenylic acid.

PMID- 1018320
TI  - Units of functional stability in bacteriophage messenger RNA.

PMID- 1018321
TI  - Fluctuational opening of the double helix as revealed by theoretical and
      experimental study of DNA interaction with formaldehyde.

PMID- 1018322
TI  - Molecular packing of collagen: three-dimensional analysis of electrostatic
      interactions.

PMID- 1018323
TI  - Transcription of bacteriophage phi-X174 in vitro: selective initiation with
      oligonucleotides.

PMID- 1018324
TI  - Transcription of bacteriophage phiX174 in vitro: analysis with restriction
      enzymes.

PMID- 1018325
TI  - A tobacco mosaic virus mutant with non-functional coat protein and its revertant:
      relationship to the virus assembly process.

PMID- 1018326
TI  - Effects of isoproterenol on myocardial lipid metabolism in rat hearts perfused
      with and without exogenous substrates.

PMID- 1018327
TI  - Biochemical and contractile properties of heart muscle after prolonged alcohol
      administration.

PMID- 1018328
TI  - Changes in high-energy phosphate compounds of isolated rat hearts during Ca2+
      free perfusion and reperfusion with Ca2+.

PMID- 1018329
TI  - Evolutionary divergence and length of repetitive sequences in sea urchin DNA.
AB  - The organization of repetitive and single copy DNA sequences in sea urchin DNA
      has been examined with the single strand specific nuclease S1 from Aspergillus.
      Conditions and levels of enzyme were established so that single strand DNA was
      effectively digested while reassociated divergent repetitive duplexes remained
      enzyme resistant. About 25% of sea urchin DNA reassociates with repetitive
      kinetics to form S1 resistant duplexes of two distinct size classes derived from
      long and short repetitive sequences in the sea urchin genome. Fragments 2,000
      nucleotides long were reassociated to Cot 20 and subjected to controlled
      digestion with S1 nuclease. About half of the resistant duplexes (13% of the DNA)
      are short, with a mode size of about 300 nucleotide pairs. This class exhibits
      significant sequence divergence, and principally consists of repetitive sequences
      which were interspersed with single copy sequences. About one-third of the long
      duplexes (4% of the DNA) are reduced in size after extensive S1 nuclease
      digestion to about 300 nucleotide pairs. About two-thirds of the long resistant
      duplexes (8% of the DNA) remains long after extensive SI nuclease digestion.
      These long reassociated duplexes are precisely base paired. The short duplexes
      are imprecisely paired with a melting temperature about 9 degrees C below that of
      precisely paired duplexes of the same length. The relationship between length of
      repetitive duplex and precision of repetition is confirmed by an independent
      method and has been observed in the DNA of a number of species over a wide
      phylogenetic area.

PMID- 1018330
TI  - Hemoglobin Vancouver [alpha2beta2(73)(E17) Asp replaced by Tyr]: its structure
      and function.
AB  - Hemoglobin Vancouver is a new abnormal hemoglobin with an amino acid substitution
      of the normal aspartyl residue 73 of the beta chain by a tyrosyl residue. It was
      discovered in a man of Chinese descent in association with beta thalassemia. It
      was subsequently detected in a sister in association with normal Hb A. The oxygen
      affinity of the abnormal hemoglobin is decreased but its subunit interaction is
      normal. The Bohr effect may be slightly increased. This is the fourth abnormal
      hemoglobin to be found with a substitution at beta73. The others are Hb C-Harlem
      (alpha2beta2 6Glu replaced by Val and 73 Asp replaced by Asn), Hb Korle-Bu
      (alpha2beta2 73Asp replaced by Asn), and Hb Mobile (alpha2beta2 73Asp replaced by
      Val). Although Hb Mobile was found in the present studies to have a decreased
      affinity for oxygen, Hbs C-Harlem and Korle-Bu have been reported to be normal.
      These observations of functional differences for variants of beta73 added to
      earlier observations of the role of the normal beta73 residue to the aggregation
      of sickle deoxyhemoglobin indicate that this position of the molecule may be
      important in intra as well as intermolecular interactions.

PMID- 1018331
TI  - Congruency of phylogenies derived from different proteins. A molecular analysis
      of the phylogenetic position of cracid birds.
AB  - This communication examines the question of phylogenetic congruency--i.e.,
      whether or not the branching order of evolutionary trees is independent of the
      protein studied. It was found that trees constructed for birds on the basis of
      immunological comparison of their transferrins, albumins, and ovalbumins agree
      approximately with a published tree based on the amino acid sequences of their
      lysozymes c. This congruency is especially noteworthy with respect to the
      phylogenetic position of the chachalaca, a Mexican bird classified on
      morphological grounds in the family Cracidae of the order Galliformes. At the
      protein level, this species differs as much from non-cracid galliform birds as
      does the duck, which belongs to another order. Despite the organismal similarity
      between cracid and non-cracid galliform birds, the molecular relationship is
      remote. If this contrast between organismal and molecular results had been based
      on comparative studies with only lysozyme, one could have ascribed the contrast
      to the possibility that chachalaca lysozyme was paralogous, rather than
      orthologous, to the other bird lysozymes c. Examination of several proteins is
      thus desirable in cases of possible paralogy.

PMID- 1018332
TI  - Origin of organic compounds on the primitive earth and in meteorites.
AB  - The role and relative contributions of different forms of energy to the synthesis
      of amino acids and other organic compounds on the primitive earth, in the parent
      bodies or carbonaceous chondrites, and in the solar nebula are examined. A single
      source of energy or a single process would not account for all the organic
      compounds synthesized in the solar system. Electric discharges appear to produce
      amino acids more efficiently than other sources of energy and the composition of
      the synthesized amino acids is qualitatively similar to those found in the
      Murchison meteorite. Ultraviolet light is also likely to have played a major role
      in prebiotic synthesis. Although the energy in the sun's spectrum that can be
      absorbed by the major constituents of the primitive atmosphere is not large,
      reactive trace components such as H2S and formaldehyde absorb at longer
      wavelengths where greater amounts of energy are available and produce amino acids
      by reactions involving hot hydrogen atoms. The thermal reaction of CO + H2 + NH3
      on Fischer-Tropsch catalysts generates intermediates that lead to amino acids and
      other organic compounds that have been found in meteorites. However, this
      synthesis appears to be less efficient than electric discharges and to require a
      special set of reaction conditions. It should be emphasized that after the
      reactive organic intermediates are generated by the above processes, the
      subsequent reactions which produce the more complete biochemical compounds are
      low temperature homogenous reactions occurring in an aqueous environment.

PMID- 1018333
TI  - A basic study of the Hanssen technique for evaluation of single nephron
      glomerular filtration rate.
AB  - The purpose of this study was mainly to examine some basic problems of the
      Hanssen technique for the evaluation of single nephron glomerular filtration rate
      (SNGFR). Firstly, experiments were performed using Wistar rats to determine the
      amount of C14-ferrocyanide necessary to give sufficient C14 radioactivity in
      dissected nephrons. Using 200 muCi of C14-ferrocyanide, the samples of dissected
      nephrons provided only twice as much as background. Hence, we chose the amount of
      600 to 700 muCi of C14-ferrocyanide for each rat in the later experiments, which
      yielded the radioactivity 5 to 6 times as much as background. Secondly, the
      homogeneity of intrarenal C14-ferrocyanide distribution was tested. Five
      superficial (SUP) and juxtamedullary (JM) proximal tubules four different regions
      were dissected and the radioactivity of those nephrons was counted. The
      distribution of C14-ferrocyanide in each piece was representative of the overal
      distribution. The summary of morphologic and clearance studies were as follows.
      The mean lengths of proximal tubules of 40 SUP nephrons, 5.3 +/- 0.2 mm, and 39
      JM nephrons, 6.3 +/- 0.1 mm, were significantly different (P less than 0.01). The
      mean glomerular diameter of the JM nephrons, 110 +/- 2.7 mu, was significantly
      greater than that of the SUP nephrons, 95 +/- 3.1 mu (P less than 0.01). The mean
      SNGFR of 129 SUP nephrons, 23.4 +/- 4.2 nl/min/100g Body Weight (BW), and that of
      130 JM nephrons, 34.5 +/- 5.1 nl/min/100g BW, were significantly different (P
      less than 0.01). The ratio of superficial/juxtamedullary nephron glomerular
      filtration rate (S/JM Ratio) was 0.85 +/- 0.02. We conclude that C14-ferrocyanide
      is regularly distributed to the kidney and that it is necessary to infuse
      sufficient amount of C14-ferrocyanide in this technique.

PMID- 1018334
TI  - The effects of atropine on atrio-ventricular conduction in patients with Wolff
      Parkinson-White syndrome. Studies with His bundle electrogram.
AB  - The effects of atropine on normal and anomalous A-V pathways were investigated
      using HBE in 40 cases consisting of 25 subjects without pre-excitation (group I)
      and 15 cases with WPW syndrome (group II). In group I, A-H interval shortened
      with a mean decrease of 30% following the administration of atropine (p less than
      0.001), while P-A and H-V intervals as well as QRS duration remained unchanged.
      In group II the electrocardiogram showed WPW syndrome pattern (pattern W) in 12,
      normalization (pattern N) in 1 and both patterns (pattern WN) in 2 cases during
      the control study. In 10 cases pattern W persisted after atropine. Atropine
      changed pattern W to WN in 2 cases, WN to W in 1, WN to N in 1 and N to WN in one
      case. P-d interval remained constant. Atropine had no effect on the conduction
      time within atrium. His-Purkinje system and anomalous A-V pathway, but
      accelerated the transmission through A-V node. Atropine decreased the QRS
      duration of pattern W in 11 of 13 cases showing pattern W or WN both before and
      after atropine. Since the QRS duration showing pattern W correlated with P-H
      interval and (see article) and had the negative correlation with H-d interval (p
      less than 0.001), fusion mechanism was considered as the genesis of
      electrocardiographic pattern in most cases with WPW syndrome. Atropine influence
      was negative on QRS complex of pattern W i2 cases showing the co-existence of
      Kent bundle and James fibers or exclusive Kent bundle conduction. In the latter
      case the selection of antiarrhythmic agents should be made with caution. A-V
      dissociation with junctional rhythm developed in 9 cases (4 in group II) within 2
      and a half minutes after atropine. The duration was as short as 15 seconds or
      less in 6 cases. The continuous tracing is necessary not to miss the AV
      dissociation. The disappearance of delta wave after atropine was observed during
      the change to pattern WN and the occurrence of A-V junctional rhythm or beat in 5
      of 12 cases showing pattern W prior to the drug administration, and right bundle
      branch block was disclosed in 2 cases. The normalization of QRS complex also made
      it possible to measure His-Purkinje conduction time. In this point atropine is
      superior to the other antiarrhythmic agents which prolong H-V interval.
      Paroxysmal supraventricular tachycardia induced after atropine revealed shorter A
      H with fixed H-V and V-A intervals, compared with the tachycardia before atropine
      in one case. The administration of atropine serves as an aid to evaluate the
      participation of anomalous A-V pathway in the tachycardia circuit.

PMID- 1018335
TI  - Experimental studies of effects of acute renal venous congestion on renal
      function --with particular reference to renal arterio-venous plasma sodium
      difference.
AB  - Effects of acute renal venous congestion on renal function were studies. In
      anesthetized mongrels with intermittent or sustained elevation of the renal
      venous pressure produced experimentally by unilateral constriction of the renal
      vein, changes in renal function were investigated with the clearance method and
      plasma concentrations of electrolytes, protein and Ht of collected arterial and
      venous blood oals were divided into two groups according to the initial
      conditions concerning the various level of renal arterio-venous plasma sodium. In
      dogs (Group A) whose initial values of renal arterio-venous plasma sodium
      difference were not less than -1 mEq/L, the difference showed a negative tendency
      both during intermittent and during continuous congestion. In dogs (Group B)
      whose initial values of the difference were less than -1 mEq/L, the difference
      showed a positive tendency during renal venous congestion. (2) In dogs of Group
      A, i) the sodium reabsorption rate increased when renal physiological values (GFR
      and RPF) remained unchanged (during intermittent congestion) as well as when
      these values decreased (during continuous congestion). ii) The calculated
      "postglomerular" oncotic pressure and the sodium reabsorption rate were strongly
      correlated at the control period, showing a slightly less correlation during
      intermittent renal congestion, whereas during sustained congestion, the latter
      increased independently of the former. iii) The NCPF/CPAH remained unchanged or
      slightly increased during intermittent congestion and was remarkably elevated
      during sustained congestion. (3) In dogs of Group B, i) Diminution of renal
      functions such as GFR and RPF was prominent during renal congestin and
      satisfactory recovery of renal functions to the initial level did not occur even
      after release from congestion. ii) No significant increase of sodium reabsorption
      rate was obtained during continuous renal congestion. (4) The balance of sodium
      ion between the kidney and blood of dogs of Group A was discussed. The effects of
      acute renal venous congestion on renal function were divided into two groups and
      it was concluded that this renal arteriovenous plasma sodium difference is a most
      significant factor.

PMID- 1018336
TI  - Effect of changes in inputs to atrioventricular node on AV conduction.
AB  - The effect of different inputs into the atrioventricular node (AVN) on orthograde
      impulse transmission was studied. In rabbit AVN preparations, two stimulating
      electrodes were placed posteriorly in the crista terminalis (P) and anteriorly in
      the interatrial septum (A). Electric stimuli were given individually (P,A) or
      simultaneously (P + A). Premature stimulation, when properly timed (e.g. 70-100
      msec at the basic cycle length of 400 msec) achieved AV conduction only in P + A
      but not in either P or A. Action potentials (APs) in AVN in this situation
      revealed an incomplete depolarization in P and A, but became a fullsized AP in P
      + A. This might be explained by summation. The site of simmation appeared to be
      in the upper node, because APs distal to the middle node as well as APs in the
      His bundle behaved in an "all or none" fashion. Time intervals between the
      stimulus artifact and the His bundle AP upstroke (S-H) were shorter in P + A was
      enhanced with the decrease of the S-H difference between P and A suggested an
      accelerated conduction by summation in AVN. A hyperpolarizing current flowing
      through the suction electrodes which were attached in the vicinity of AVN caused
      different amounts of S-H shortening between P and A input. The above data support
      the view that AVN has a summating property engendered by the slow inactivation of
      ionic channel on which the upstroke of AP depends and by the limited number and
      sites of atrial inputs which might connect with some preferential paths within
      the AVN.

PMID- 1018337
TI  - Responses of the His-Purkinje conducting system to supraventricular premature
      beats--in vitro and in vivo canine experiments on ventricular aberrant
      conduction.

PMID- 1018338
TI  - Automaticity and time-dependent conduction disturbance produced in canine
      ventricular myocardium. New aspects for initiation of ventricular arrhythmias.
AB  - 1) In isolated canine ventricular myocardium, automaticity could be induced by a
      passage of small depolarizing DC-currents. The mechanism was attributed to
      inflowing Ca++ and Na+ currents and time-dependent deactivation of outward K+
      current under a condition of high membrane resistance due to an anomalous
      rectification. Significance of the automaticity was discussed in relation to the
      ventricular arrhythmias encountered in very early stage of myocardial infarction.
      2) In in situ canine hearts, chloropromazine induced time (preceding cycle
      length)-dependent decrease in conduction velocity within the ventricle. Thus QRS
      duration of non-premature beats was lenghtened at rapid pacing rates while QRS
      duration of atrial premature beats was lengthened also at short coupling
      intervals in the drug-treated dogs. These slow conductions were not due to
      reduced take-off potential of action potentials bue due to drug-induced slow
      recovery of rapid Na+ system. The phenomenon may be responsible for reported QRS
      prolongation and fatal ventricular arrhythmias encountered in the patients
      receiving phenothiazines.

PMID- 1018339
TI  - Role of slow inward current in the genesis of ventricular arrhythmia.
AB  - Action potentials of premature beats in ventricular muscle fibers showed a
      transient prolongation of duration as well as an increase in second
      depolarization of the plateau phase when the preceding diastolic intervals were
      progressively shortened. These changes were abolished by manganese ions. Voltage
      clamp experiments also disclosed a transient increase in slow inward current in
      premature excitations, of which time course was very similar to that in action
      potential changes. These results suggested that prolongation of action potential
      durations was mainly brought about by changes in slow inward current and this was
      partly related to the characteristics of recovery from inactivation of this
      current. An increase of slow inward current produced depressed conduction on the
      subsequent beat and it also shared the effects to extend the areas of slow
      response. These effects may accelerate the occurrence of re-entry.

PMID- 1018340
TI  - Mechanism of supraventricular tachycardia and pharmacological effects on it.
AB  - Electrophysiologic study in 30 patients with documented SVT, 16 of whom had
      preexcitation, and in 24 control subjects were reported. The mechanism of SVT
      were found to be various and to include reentry confined to the AV node, SA node
      or the atrium, reentry through accessory pathway and ectopic atrial automaticity.
      It was noted that some of SVT might use concealed accessory pathway in VA
      direction while the some of SVT in WPW syndrome might not utilize accessory
      pathways. Electrophysiological properties in cases with SVT did not differ from
      those observed in controls. There were no differences in the mode of
      electrophysiological action of drugs between XVT and control groups. Both
      propranolol and procaine amide slightly depressed AV conduction. However, the
      action of the drugs on echo zone were not the same. The basic mechanisms of the
      action of the drugs in SVT were discussed.

PMID- 1018341
TI  - Role of the autonomic nerves in the pathogenesis of primary ventricular
      fibrillation: experimental and clinical studies in dogs and man.

PMID- 1018342
TI  - Electrophysiological mechanisms for digitalis arrhythmias.

PMID- 1018343
TI  - Purification of host DNA synthesis-suppressing factor (DSF) produced by infection
      with measles virus.
AB  - Host DNA synthesis-suppressing factor (DSF) produced into culture fluid of cloned
      HeLa cells (HeLa C-9) infected with a small plaque variant of Toyoshima strain of
      measles virus was purified by precipitation with ammonium sulfate, chromatography
      on CM-cellulose and DEAE-cellulose, and gel-filtration on Sephadex G-100 and G
      200. The specific activity of the finally purified DSF was 302 units/mg of
      protein representing approximately 300-fold purification. The molecular weight of
      DSF was estimated to be about 55 000. By isoelectric focusing, two kinds of DSF
      having isoelectric points of 4.24 and 5.24 were detectable. The purified DSF was
      able to suppress host DNA synthesis of HeLa cells, continuous human lymphoid
      cells (NC-37), mouse L cells and Meth-A cells derived from an ascitic tumor of
      the mouse. The activity of the purified DSF was inactivated by heating at 56 C
      for 30 min or by treatment with trypsin.

PMID- 1018344
TI  - Isolation of a small rod with lytic activity against Vibrio parahaemolyticus from
      fresh sea water.
AB  - A small rod, capable of formine crater-like plaques on lawns of Vibrio
      parahaemolyticus, was isolated from a marine environment. The isolate was a gram
      negative straight rod with round ends and was small in size, equal to that of
      halophilic Bdellovibrio strain 5501. The isolate appeared to have close taxonomic
      relationships to Cytophaga, since this bacterium moved slowly in a gliding manner
      on a solid agar surface, hydrolyzed agar and starch, contained yellow pigment and
      was halophilic. The isolate was able to grow not only under host-dependent but
      also under host-independent conditions when low nutrient media were used for
      cultivation, and its bacteriolytic mode was different from that of Bdellovibrio,
      an endoparasite. The isolate was halophilic and required Mg++ and Ca++ in
      addition to 3% saline for growth. The isolate showed a broad host rnage when
      tested for plaque-forming activity on gram-negative bacteria but not on the gram
      positive bacteria tested so far.

PMID- 1018345
TI  - Binding of tobacco mosaic virus to membrane material isolated from tobacco
      leaves.
AB  - Binding of tobacco mosaic virus (TMV) to disrupted tobacco leaf membrane was
      studied. Membrane isolated from tobacco leaves was treated successively with
      (NH4)2SO4, Li-diiodosalicylate and then pronase. TMV-binding substance was thus
      isolated in a soluble form. From enzymatic digestion experiments, it was
      suggested that the binding substance was composed of lipid and carbohydrate.

PMID- 1018346
TI  - Mycobacterium intracellulare from public bath water.

PMID- 1018347
TI  - Lymphocyte responsiveness to phytohemagglutinin (PHA) and serum inhibitory effect
      in patients with gastric cancer.
AB  - The in vitro lymphocyte response to PHA was determined in patients with gastric
      cancer in various stages prior to the surgical treatment. The lymphocyte
      responsiveness in the presence of homologous pooled AB serum in patients of
      stages II, III and IV were markedly reduced as compared with that in healthy
      controls (stages II, III; p less than 0.05, stage IV; p less than 0.01).
      Inhibition of normal lymphocyte responsiveness to PHA by serum from patients in
      stages III and IV were statistically significant only in the advanced stage. It
      was concluded that the suppression of the immune response in the early stage of
      gastric cancer was mainly due to the impairment of lymphocyte itself, which
      advanced with the progress of the stage and was modified by the serum inhibitory
      effect in advanced stages. In patients with advanced cancer, the higher was the
      lymphocyte responsiveness to PHA and PWM prior to the initial treatment, the more
      effective was the immunotherapy. This shows that the indication of the
      immunotherapy in patients with advanced cancer could be initiated. Furthermore,
      the correlation between the lymphocyte responsiveness to PHA and the clinical
      results of immunotherapy was discussed.

PMID- 1018348
TI  - Carcinomas of the stomach in the young adults.
AB  - The clinical and pathologic characteristics of the gastric carcinomas in the
      young adults were described in special comparison with the carcinomas in the old
      men. They were found to be similar in many respects, but had some different
      features like the histologic findings with particular references to the
      histogenetic background.

PMID- 1018349
TI  - Evaluation of hepatic reserve for surgical treatment in portal hypertension.
AB  - Based on a hepatic hemodynamic study, estimated by hepatic catheterization
      technique in 233 patients of portal hypertension, a classification of hepatic
      reserve is proposed. Surgical treatments for preventing esophageal variceal
      bleeding which does not decrease portal pressure may safely be applied to the
      patients whose effective hepatic blood flow of over 300 ml/min/M2, intrahepatic
      shunting rate below 40 per cent, IGC disappearance rate of over 0.04 min-1, or
      BSP 30 minute retention rate of below 35 per cent.

PMID- 1018350
TI  - Percutaneous transtracheal ventilation.
AB  - The technique of percutaneous transtracheal ventilation (intermittent  jets of
      oxygen under high pressure, 50 pounds per square inch [psi]) has been used for
      resuscitation during anesthesia and prior to tracheostomy, and has been
      established as an important adjunct to life-support techniques. The technical
      aspects are described together with experimental evidence that intermittent jet
      ventilation is necessary to eliminate carbon dioxide. The complications occurring
      with a series of 80 patients are reported along with experimental work in
      ventilation of dogs with compressed air sources, including truck tires. Emergency
      physicians should be familiar with this technique and equipment for its use
      should be readily available in the emergency department. The potential role of
      transtracheal ventilation in the mobile intensive care unit at accident sites has
      been explored and appears promising. Conventional airway support techniques
      should be applied prior to resorting to transtracheal ventilation.

PMID- 1018351
TI  - Hydrocarbon ingestion in children: a six-year retrospective study.
AB  - The results of a six-year retrospective study of 116 children admitted with the
      diagnosis of hydrocarbon ingestion showed that the major toxicity of hydrocarbons
      was to the respiratory tract, with 79 patients (68%) developing pneumonia. There
      was a significantly higher initial white blood cell count in children who
      developed pneumonia (15,900/cu mm vs 12,000/cu mm, p less than .001). All
      hydrocarbon products studied had a similar incidence of complicatons, except
      turpentine products, which had a significantly lower incidence of pneumonia (p
      less than .005). There was no correlation between amount ingested and development
      of complicatons. Initial treatment, which consisted of induced vomiting, gastric
      lavage, administration of oil or saline cathartics, was not associated with fewer
      complications. Oil administration correlated with higher incidence of pneumonia
      (p less than .025). The present study recomends only supportive treatment
      following hydrocarbon ingestion in children.

PMID- 1018352
TI  - Caffeine intoxication: a case of paroxysmal atrial tachycardia.
AB  - Caffeinism is a syndrome resulting from the excessive ingestion of caffeine and
      characterized primarily by cardiovascular and central nervous system
      manifestations. A variety of tachyarrhythmias and extrasystoles are believed to
      reflect the toxic, cardiotonic effects of caffeine. A case of paroxysmal atrial
      tachycardia (PAT) related to caffeine abuse is PAT. The importance of considering
      this and other less frequent conditions as potential causes for this arrhythmia
      is stressed.

PMID- 1018353
TI  - Jarisch-Herxheimer reaction. Case report.
AB  - The Jarisch-Herxheimer reaction is a response to the treatment of syphilis. The
      most common findings are fever, malaise, headache, and exacerbation of cutaneous
      lesions. The reaction is thought to be due to the effects of treponema breakdown
      products, and it should not be confused with an allergic reaction to the
      antibiotic employed. Thus, further therapy must not be withheld. Treatment is
      symptomatic.

PMID- 1018354
TI  - A conceptual framework for emergency care planning.
AB  - The experience of functional program planning, in addition to facilitating the
      planning process for a new emergency unit, has had additional benefits. It has
      given the staff a common conceptual framework for analyzing patient care as
      provided and for identifying areas where improvements can be made. Also, a new
      approach has been developed for communicating with other departments and with
      hospital administration about day-to-day operating problems which may be useful
      for addressing other resource allocating and operating room time schedules. By
      developing a planning framework, it is possible to integrate the expertise of
      various services, while retaining an integrated overall orientation within which
      the efficacy of different proposals can be judged. This approach is critically
      important in helping to avoid the adverse effects of fragmented planning.

PMID- 1018355
TI  - The emergency joint: arthrocentesis and synovial fluid analysis.
AB  - Arthrocentesis and the subsequent evaluation of synovial fluid is often the
      definitive diagnostic procedure for the patient presenting with a joint effusion
      or intrasynovial hemorrhage. The difficulty of performing arthrocentesis varies
      with the joint in question, but those joints most frequently involved are easily
      entered. The indications and contraindications for this procedure are discussed.
      Effusion-producing pathologic processes often yield fluids of a characteristic
      nature permitting their classifications into categories of noninflammatory (Group
      I), inflammatory (Group II), septic (Group III), and hemorrhagic. This
      categorization of the effusion may permit specific diagnosis or the narrowing of
      the differential diagnosis. Criteria are established on the basis of joint fluid
      features to differentiate septic arthritis, which requires inpatient treatment,
      from those entities for which the patient may reasonably be treated as an
      outpatient.

PMID- 1018356
TI  - The American College of Emergency Physicians in the bicentennial year.

PMID- 1018357
TI  - A cautionary note about PTV.

PMID- 1018358
TI  - Cold injury from skin refrigerants.

PMID- 1018359
TI  - Insect sting reactions.

PMID- 1018360
TI  - Algorithm-directed triage in an emergency department.
AB  - At Brooke Army Medical Center the Emergency Services Section has developed an
      algorith,-directed triage system to be used by "screeners" who may be basic
      medical corpsmen but sometimes have had no previous medical experience. After 25
      hours of classroom and 120 hours of on-the-job training, the screeners use the
      algorithms to triage patients into one of three treatment areas in the emergency
      section or to clinics outside the emergency section during the day and evening.
      The screeners may consult with a triage physician if the algorithm-directed
      disposition appears inappropriate, Triage dispositions of 78,822 patient visits
      during the calendar year 1975 are presented.

PMID- 1018361
TI  - Effectiveness of nurse triage in the emergency department of an urban county
      hospital.
AB  - The effectiveness of patient triage by a specially trained registered nurse in
      the emergency department of an urban county hospital, San Francisco General
      Hospital, was evaluated over a three-month period. Ambulatory patients thought to
      have nonemergent illnesses were directed to the Walk-In Service for physician
      evaluation and treatment; the remainder were seen in the Emergency Service. In
      three months, 11,329 patients registered for care, and 4,150 (37%) were referred
      to the Walk-In Service. Of the 77 admitted patients, six were thought to require
      treatment within a few hours, 67 within hours to days, and four were considered
      elective admissions. There were no deaths. Error in triage was about equally
      divided between mistaken diagnosis and underestimated severity of illnes. The
      overall accuracy of triage was 98%.

PMID- 1018362
TI  - Laryngotracheal trauma: recognition and management.
AB  - In 23 patients with laryngotracheal trauma at the Louisville General Hospital
      during a ten-year period, 19 survived. One death was directly atributable to the
      airway injury. The most common postinjury complication was hoarsensess
      attributable to direct injury to the cords or recurrent nerve paralysis. One
      patient had further operation for subglottic stenosis. In general, blunt injuries
      were more severe than penetrating injuries. Subcutaneous emphysema, aphonia or
      dyshonia, hemoptysis, signs of injuries, a sucking wound, are presumptive
      findings of laryngotracheal injury. Appropriate endoscopy and radiographic
      studies should confirm the diagnosis. Control of the airway is achieved by
      emergency tracheostomy or intubation followed by tracheostomy. Prompt operative
      intervention and primary repair follow.

PMID- 1018363
TI  - Rape evidence kit: simplified procedures for the emergency department.
AB  - The crime of rape requires medical evaluation and therapy concomitant with the
      collection of legal evidence for potential prosecution. A practical, inexpensive
      evidence kit has been disigned that meets the needs of the local health
      department, police department, hospital emergency centers, and district attorney
      personnel. Costs of assembly and specimen analysis are assumed by the police
      department. Chain of custody is assured through tamper-proof bags, appropriate
      reporting forms and police involvement in specimen pick-up. Victims participate
      in chain of custody by sharing in collection and authorization. The requirement
      for physician appearance in court is thus lessened. Standardization of
      examination and reporting prompts all community hospitals to share in
      examinations, preventing over loading of a single, busy facility. Six months'
      experience had borne out the anticipated simplification of collection,
      standardization of reporting, and reduction of physician involvement in legal
      procedures.

PMID- 1018364
TI  - Public relations in the emergency department.

PMID- 1018365
TI  - Status epilepticus.

PMID- 1018366
TI  - The role of the emergency physician in mass casualty/disaster management. ACEP
      position paper.

PMID- 1018367
TI  - Quo vadis--UA/EMS? (University Association for Emergency Medical Services)

PMID- 1018368
TI  - The President of the United States of America: a neglected person in our
      emergency medical system.

PMID- 1018369
TI  - Drugs given or prescribed in the emergency department.

PMID- 1018370
TI  - Emergency medicine and family practice - room for both.

PMID- 1018371
TI  - Updated reprint filing system for the emergency physician.

PMID- 1018372
TI  - The crush injury: a high risk wound.
AB  - A standardized experimental impact injury model was developed to produce soft
      tissue trauma that simulated impact injuries to soft tissue overlying the
      cranium. An aluminum impact instrument was constructed so as to deliver a
      measured amount of energy to a finite area of soft tissue over a fixed
      foundation. Impact injury resulted in readily demonstrable changes in the
      morphology of the tissue and its blood flow. As measured by the distribution of
      fluorescein dye, the blood flow to the impact site was considerably less than
      that to unwounded tissue. The magnitude of this reduction in blood flow to the
      site of injury was proportional to the level of energy absorbed by the tissue.
      The injury to skin resulting from the impact was restricted primarily to the
      subcutaneous tissue and panniculus carnosus. Loss of adipose tissue and necrosis
      of skeletal muscle fibers in these layers were associated with the development of
      a dense inflammatory infiltrate. The structural damage to the tissue and its
      reduced perfusion were correlated with the tissue's increased susceptibility to
      infection by bacteria delivered either by direct infection or as a result of a
      bacteremia. The magnitude of this damage to the host's defenses is, again,
      directly related to the amount of energy absorbed per unit area of soft tissue.
      Antibiotics did suppress the growth of bacteria in these experimental soft tissue
      impact wounds, even when treatment was delayed eight hours. While the therapeutic
      efficacy of antibiotics was readily apparent in soft tissue impact wounds, the
      degree to which they could suppress bacteria in these wounds was less than that
      encountered in the treated control wounds not subjected to impact.

PMID- 1018373
TI  - Provider performance in the recognition and treatment of telemetered
      electrocardiogram patterns.
AB  - A test of electrocardiogram diagnostic skills in the form of a ten-slide
      presentation of six-second rhythm strips was administered to 25 emergency
      department nurses, 23 intensive care unit (ICU) nurses, 34 cardiac technicians
      (CRT, EMT) and 37 physicians. The ICU nurses had the best performance overall.
      Physicians had difficulty with mechanical problems, viz, loose leads, flat line
      and inverted leads. ICU nurses had less difficulty identifying and treating flat
      line than did emergency department nurses. The study's limitations were that the
      sample was self-selected and that the providers might respond differently to a
      real life situation.

PMID- 1018374
TI  - A unique academic approach to critical care-emergency medicine training.
AB  - The four-year program for training physicians in critical care-emergency medicine
      at Sacramento Medical Center, University of California, Davis School of Medicine
      is described. Its purpose is to train the physician in resuscitation, emergency
      care for life-threatening conditions, and intensive care, so that the graduate
      can staff community hospital emergency departments and intensive care units, be
      director of an emergency department or intensive care unit, or pursue an academic
      career in emergency medicine.

PMID- 1018375
TI  - Abscess formation as a complication of parenteral methylphenidate abuse.
AB  - Case reports of five patients suffering from either skin abscesses or cellulitis
      following parenteral methylphenidate abuse are presented. Four patients had
      similar lesions consisting of abscesses or cellulitis which demonstrated typical
      signs and symptoms of an infective process and were treated with local
      symptomatic therapy, incision and drainage if indicated, and systemic
      antibiotics. The fifth patient suffered from a circular, necrotic, nonpurulent
      ulcer on the dorsum of the right foot which produced no local or systemic toxic
      effects. Attempts to culture a responsible organism yielded Streptococcus
      viridans, an organism which is normal flora of the skin and, although
      opportunistic, is generally considered nonpathogenic. These cases further
      substantiate the belief that local vasospasm, chemical irritation, or both,
      produced by the methylphenidate solution may primarily cause a necrotic ulcer
      susceptibble to secondary bacterial infection.

PMID- 1018376
TI  - Xylocaine viscous as an aid in the differential diagnosis of chest pain.
AB  - Sixty patients with chest pain, chest and epigastric pain, or predominantly
      epigastric pain, not explained by electrocardiographic (EKG) changes or pulmonary
      findings, were given 20 cc of Xylocaine Viscous orally. Thirty-seven out of 60
      experienced complete or almost complete relief within 10 to 15 minutes. Of this
      group, none were found to have suffered a myocardial infarction. Of the 23
      patients who did not experience pain relief, six had a myocardial infarction and
      seven were diagnosed as having cardiac angina. Determination of serum lidocaine
      levels after oral ingestion of 20 cc of Xylocaine Viscous in patients with normal
      gastric function demonstrated a maximum level of 0.55 mu/ml--a serum level
      unlikely to result in adverse side effects.

PMID- 1018377
TI  - Can the well trained EMT-paramedic maintain skills and knowledge?
AB  - Reliable criteria exist to assess emergency medical technician (EMT)-paramedic
      team and individual competence. In addition to written and oral examiniation,
      reliable individual manipulative skill data, and on-scene observation of
      emergency care by responsible physicians, EMT-paramedic team competence may be
      assessed by using tracer conditions that reflect patient outcome converted to a
      standard base population per unit time. Using standard definitions of
      "resuscitation" and "save," and the pulseless, nonbreathing patient as tracer, 75
      (31%) of 241 patients were resuscitated and 34 (14%) were saved. Team
      manipulative skill competence may also be determined by an appropriate tracer.

PMID- 1018378
TI  - The portable Doppler: practical applications in EMS care.
AB  - The practical application of a new, commercially available, portable Doppler
      ultrasound device to the operation of a busy city-county emergency department and
      ambulance service was investigated. An initial evaluation using healthy
      volunteers confirmed accuracy and reproducibility of the Doppler blood pressure
      readings comparable to that of auscultatory and palpatory measurement. In
      selected patients, the Doppler readings correlated well with readings from
      patients who had intra-arterial lines. When used in several low flow states, such
      as testing adequacy of cardiopulmonary resuscitation (CPR) and verification of
      electromechanical dissociation, the Doppler aided the clinical evaluation and
      treatment in many cases where traditional methods were useless. The Doppler was
      also helpful in the evaluation of local arterial injury but this unit was not
      found sensitive enough for venous disease. Finally, the Doppler enhanced the
      obtaining of vital signs in the noisy environment of our ambulances.

PMID- 1018379
TI  - A caveat for xylocaine viscous and chest pain.

PMID- 1018381
TI  - Plea for research in emergency medicine.

PMID- 1018380
TI  - Public Law 93-641 and the emergency physician.

PMID- 1018382
TI  - Phenothiazines and anticholinergics in heat stroke.

PMID- 1018383
TI  - Prehospital use of the military anti-shock trouser (MAST).
AB  - Complications of prehospital use of the military anti-shock trouser (MAST) in
      treating hypotensive and hypovolemic patients have been few and minor.
      Undesirable consequences--compromised respiratory excursion or autonomic
      disturbances such as emesis, urination or defecation--were rare. Forty-seven
      (88.7%) of 53 patients with conditions classed as potentially lethal or severe
      survived. Close communications between prehospital and emergency department
      personnel can assure accurate transmission of circumstances of MAST application
      and result in optimal responses and improved inhospital patient care. Both "false
      positives" (supposed initial hypotension or hypovolemia) and "false negatives"
      (seeming stability in the face of major anatomic derangements) require a
      carefully structured operational sequence. Further evaluation of the device,
      particularly in cardiovascular/cardiopulmonary cases, is in progress.

PMID- 1018384
TI  - Resuscitation--opening the airway. A comparative study of techniques for opening
      an airway obstructed by the tongue.
AB  - The effectiveness of three techniques for opening an airway obstructed by the
      tongue was studied and compared. The research involved patients who were
      anesthetized for elective surgery. The first group of patients, not breathing on
      their own, were ventilated by mouth-to-mouth breathing. The second group was
      unconscious, making spontaneous respiratory effort, but had total airway
      obstruction produced by the tongue from relaxation of the lower jaw. The three
      techniques--neck lift, chin lift, and jaw thrust--were performed on all patients
      in both groups. The adequacy of ventilation was compared subjectively and by
      measuring air flow with a Wright Respirometer. Results indicate that the chin
      lift technique provides the most consistently adequate airway.

PMID- 1018385
TI  - Spontaneous bladder rupture: rare cause of peritonitis.
AB  - Spontaneous rupture of the urinary bladder is an uncommon, but important, cause
      of generalized peritonitis. It is a surgical emergency which may be rapidly fatal
      if diagnosis and treatment are delayed. Bladder disease or obstruction, coupled
      with a sudden increase in intra-abdominal pressure usually accounts for the
      rupture. Characteristic symptoms are acute lower abdominal pain followed by
      generalized peritonitis. In most cases, the rupture is intra-peritoneal.

PMID- 1018386
TI  - Hypothermia--a sign of hypoglycemia.
AB  - Hypothermia may occur in association with hypoglycemia, and indeed may be the
      only sign. Two cases are presented. In one, the patient presented with
      hypoglycemic encephalopathy. In the insulin dependent diabetic, the condition is
      life-threatening. Subnormal temperature is a clue to hypoglycemia in the
      alcoholic. The mechanism of hypothermia has been extensively studied, but remains
      unclear.

PMID- 1018387
TI  - An emergency intravenous route for the pediatric patient.
AB  - In pediatric patients, percutaneous venipuncture is preferable to cutdown,
      especially in inexperienced hands. The best route for maintenance fluid
      administration is a  No. 19, No. 21 or No. 23 scalp vein needle or No. 18 or No.
      20 plastic cannula placed in a superficial hand or foot vein. An incision 1 cm
      proximal to the medial malleolus of the tibia over the great saphenous vein is
      the classic pediatric cutdown. Other alternatives are brachial vein, saphenous
      vein distal to the medial aspect of the knee and, in extreme emergencies, the
      external jugular vein or cephalic vein in the arm. The cutdown technique with
      facilitating suggestions and possible dangers is described.

PMID- 1018388
TI  - Emergency medicine condition/skills list.

PMID- 1018389
TI  - Emergency medical technician-paramedic training.
AB  - With a nationally standardized emergency medical technician-paramedic training
      program soon to be adopted, certain factors in the planning of training programs
      should be emphasized. (1) The facilities should provide an opportunity for the
      paramedics to gain clinical experience in intensive care units and emergency
      departments. Teaching must be appropriate to the students' educational
      background. (2) The course content should include advanced life-support. (3) Full
      time and part-time programs must be developed, possibly using a modular format.
      (4) The operating procedure should conform to local medical and legal practice.
      (5) Mechanisms for evaluation and recertification must be developed. (6)
      Continuing education, as important or more important than the original training,
      should be included in program planning.

PMID- 1018390
TI  - Clinical use of the "G-suit".
AB  - The "G-suit," a device for combating hypovolemic shock with external pneumatic
      counterpressure, represents an application of an old idea to a relatively common
      medical problem. Its simplicity of use and quick therapeutic effect buys time for
      the patient with hypovolemic shock, whether the suit is applied in the
      prehospital or emergency department setting.

PMID- 1018391
TI  - Southern California frostbite.

PMID- 1018392
TI  - Splint the patients, not the fractures, where they lie.

PMID- 1018393
TI  - Treatment of choice for brown recluse spider bites.

PMID- 1018394
TI  - On-the-scene emergency care by the primary physician.
AB  - One year's experience with on-the-scene emergency responses by a rural family
      physician equipped for advanced life-support is analyzed. Three (6.7%) out of 45
      consecutive emergency responses were lifesaving, specifically because the
      physician was there. No definite reduction in morbidity was documented. Accurate
      assessment of emergencies when reported and at the scene of spontaneous events
      was enhanced by the physician's familiarity with  the patient and/or the
      reporter. Economic considerations, useful equipment, and special problems
      encountered in on-the-scene emergency care are discussed. The primary physician
      is a reasonable candidate to provide on-the-scene emergency care, especially in
      communities where advanced life-support is otherwise inadequate. His properly
      equipped vehicle deserves emergency vehicle status. Simultaneous summoning of the
      physician along with other emergency personnel by a central dispatching agency
      would be ideal in these communities.

PMID- 1018395
TI  - Airway obstructed by foreign material: the Heimlich maneuver.
AB  - To investigate the application of a cough-creating thrust for the removal of
      airway-obstructing foreign material, the thrust was applied to six adult male
      anesthetized volunteers at the waist, at the low chest level, and at the midchest
      level, with the subjects in both the horizontal-lateral and the sitting
      positions. Air volume, peak air flow rate, and airway measurements were made.
      Both the low chest and midchest thrusts produced significantly better results
      than did the abdominal thrust. There were no side effects attributable to the
      thrusts. The ease of application and consistently better level of results
      indicate that the chest thrust is the technique of choice. The application of the
      chest thrust should be integrated into the concepts of basic life-support and
      cardiopulmonary resuscitation.

PMID- 1018396
TI  - Psychiatric training for emergency medicine residents on a multidisciplinary
      team.
AB  - The Cincinnati General Hospital Emergency Department has a training program for
      emergency medicine residents on a multidisciplinary emergency psychiatry team.
      This essential training should occur in the emergency department setting rather
      than in psychiatric inpatient units of state hospital settings. There are
      advantages and disadvantages to this arrangement. Nonmedical members of the
      emergency psychiatry team train and support emergency medicine residents in a
      multidisciplinary approach to treatment. Some observations are made about how the
      emergency medicine residents deal with emotionally disturbed patients. Finally,
      80% of emergency medicine residents responded to questionnaire on their reactions
      to the multidisciplinary emergency psychiatry team.

PMID- 1018398
TI  - Botulism.

PMID- 1018397
TI  - Nerve blocks of the foot.
AB  - Emergency treatment of foot injuries can be made less painful by regional block
      anesthesia. There is limited medical literature on these techniques and many
      physicians, while familiar with regional anesthesia of the upper extremity, are
      not experienced with nerve blocks in the lower extremity. Infiltration anesthesia
      of the plantar structures of the foot and toes can be very painful and may
      inhibit healing. Regional anesthesia avoids both of these problems and can prove
      effective and useful. This paper discusses the techniques and possible
      complications of nerve block anesthesia of the foot.

PMID- 1018399
TI  - Upper airway obstruction.
AB  - A large number of diseases may present  with respiratory distress. In adults,
      upper airway obstruction (UAO) is relatively rare. Consequently, UAO may
      initially be overlooked in the differential diagnosis of the dyspneic patient.
      Because it may progress rapidly, delays or errors in diagnosis can be critical.
      During an eight-month period in one emergency department, seven adult patients
      with potentially life-threatening diseases of the upper airway were seen. To
      reacquaint physicians with the syndrome of mechanical obstruction of large
      airways, several illustrative cases are presented and the syndrome is discussed.

PMID- 1018400
TI  - Relief of airway obstruction.

PMID- 1018401
TI  - The teaching of life-support technics in medical schools.

PMID- 1018402
TI  - Electrocardiographic changes in traumatized patients.

PMID- 1018403
TI  - ED surgery for the embedded broken-off needle.

PMID- 1018404
TI  - Plasma cortisol in tuberculosis.

PMID- 1018405
TI  - [Chemistry, biology, and pathology of Mycobacteria grown in vivo. 1.
      Intracellular parasitization of the organism and various types of tissue
      reactions--with special reference to experimental tuberculosis of mice].

PMID- 1018406
TI  - [Aggravation and relapse of tuberculosis studied according to therapeutic regimen
      and background factors (author's transl)].

PMID- 1018407
TI  - [Aggravation and relapse of tuberculosis before and after the clinical
      application of rifampicin (author's transl)].

PMID- 1018408
TI  - [Aggravation and relapse of pulmonary tuberculosis: with special reference to
      radiographically recognized new lesions].

PMID- 1018409
TI  - [Aggravation and relapse of tuberculosis: From a viewpoint for management of
      patients (author's transl)].

PMID- 1018410
TI  - [Standardization of the definition and grading of aggravation of pulmonary
      tuberculosis and critical comments on the definition of exacerbation established
      by the Gakken Standard].

PMID- 1018411
TI  - [Evolution of pulmonary hypertension in the late period following correction of
      congenital heart defects].
AB  - The presented analysis is based on the data of haemodynamics studies in 62
      congenital heart disease patients prior to and following surgery within 1 to 13
      years (mean -- 5 years). Patent arterial duct ligation was performed in 34 cases,
      ventricular septal defect was closed in 28. Twenty of the patients had moderate,
      42 -- high pulmonary hypertension (IIIa stage in 37 cases, IIIb stage -- in 5).
      Late postoperative haemodynamic studies have shown that Stage II patients
      demonstrated its normalization, the pulmonary artery pressure remaining above the
      normal level only in few cases in whom it had been 50 mm Hg and higher. In IIIa
      stage patients no normalization of haemodynamics is usually achieved, and in 9.1%
      of the cases an evolution of the total pulmonary resistance was noted. However, a
      distinct improvement of the haemodynamic parameters in the majority of such cases
      proves the efficacy of their urgical management. The persistence of high
      pulmonary hypertension or its progressive course in IIIb stage patients, caused
      by the spreading of the sclerotic process in the pulmonary vessles, indicates the
      inefficacy of surgery in this group of patients.

PMID- 1018412
TI  - [Echocardiography in the differential diagnosis of various forms of mitral heart
      defect].

PMID- 1018413
TI  - [Diagnosis of thrombosis of the left atrium in rheumatic heart defects, using the
      main components methods].
AB  - A new method of diagnosis of left atrial thrombosis was developed for rheumatic
      heart disease patients. The mathematic method of the main components was used
      that permits to detect the thrombosis of the left atrium in 94.3% of the cases.
      Fourteen most frequently encountered symptoms of this complication were singled
      out, the probability of the occurrence of these symptoms was calculated for the
      patients with rheumatic heart diseases and atrial fibrillation with and without
      thrombosis. A computer was employed to develop the method, while no computer is
      needed for the diagnosis itself. Symptoms from the list must be identified in the
      given patient, the digital values of the main components found in the table be
      summed up with that of the free member, with due regard of the sign, and the
      presence of the thrombus be determined on the basis of the presented chart.

PMID- 1018414
TI  - [Interpretation of a bundle of His electrogram (using the spike potentials of the
      sinus node and atrial conduction tracts in the analysis)].
AB  - Spike potentials of the sinus node and of the atrial conductivity pathways were
      recorded by way of heart microcatheterization via the subclavian vein in 40
      canine experiments and in 307 patients, using the obtained data for a more
      precise interpretation of the bundle of His electrogramme taken in the course of
      these examinations. The importance of the density of the spikes for their
      successful recording was studied, and it was found that the onset of the atrial A
      -wave preceeded that of the P-wave by 10-30 ms on ECG tracings recorded from the
      body surface. The atrial A--complex recorded with the aid of an intracardiac
      unipolar electrode from the right atrium was found to consist of a slow
      depolarization wave of the atria and of three spike potentials (A1, A2 and A3).
      The A2 spike coinsides with the peak of the P-wave in the II lead and reflects
      the moment of the impulse's arrival at the atrioventricular node along the
      Bachman and Wenkebach's tract, while the A3 spike coinsides with the termination
      of the P-wave in the II lead being dependent on the depolarization of the Torel's
      tract. The P--A interval should be measured between the sinus spike and the A2
      spike, while the A--H interval--between the A2 spike and the H-potential.

PMID- 1018415
TI  - [Coagulation of arterial and venous blood in acute myocardial infarct].
AB  - The conducted study has demonstrated that aged patients with large focal and
      transmural myocardial infarctions had coagulation changes throughout the acute
      period of the disease that manifested themselves predominantly in the arterial
      bed and displayed clear phase-wise fluctuations. The coagulability of peripheral
      venous blood failed to give a distinct picture of the true state of blood
      coagulation.

PMID- 1018416
TI  - [Interrelationship of lipid metabolic disorders and hemostasis in
      arteriosclerosis].
AB  - Proceeding from the obtained data, the authors conclude that two factors are of
      paramount importance in the pathogenesis of atherosclerosis: 1) lipid
      infiltration, 2) fibrin and platelets deposits on the vascular wall. It seems
      hardly proper to oppose the lipid-infiltrationab of pathogenesis of
      atherosclerosis to the thrombogenic one, since they do not necessarily exclude
      one another. Moreover, they seem to present two aspects of a single process: on
      the one hand, lipids increase platelet adhesion and aggregation on the vascular
      wall; on the other hand, platelets during aggregation help the penetration of
      beta-lipoproteins into the arterial wall by increasing the permeability of the
      endothelium and by adsorbing cholesterol-rich beta-lipoproteins on their own
      surface. A vicious circle occurs that must underly one of the mechanisms of the
      atherosclerosis development.

PMID- 1018417
TI  - [Effect of circulatory insufficiency on immunological indices in rheumatic heart
      defects].

PMID- 1018418
TI  - [Mechanism of the development of cardiac insufficiency in alcoholic
      myocardiopathy].

PMID- 1018419
TI  - [Thrombin clearance and the activity of complex heparin compounds during recovery
      of the function of the anticoagulation system in animals maintained on an
      atherogenic diet].

PMID- 1018420
TI  - [Cardiac insufficiency in the Democratic Republic of Vietnam].

PMID- 1018421
TI  - [Method of using Sokolow's and Lyon's electrocardiographic signs for the
      diagnosis of chronic cor pulmonale].
AB  - A method introduced by the authors for the diagnosis of chronic cor pulmonale
      based on the evaluation of Sokolov's and Lion's electrocardiographic criteria is
      described. The results presented were checked by comparing the pathoanatomic data
      of 124 patients dying of chronic pulmonary lesions, as well as the analysis data
      of ECG recorded in 92 normal individuals with a vertical or semi-vertical
      electric position of the heart. The advantages of the suggested method over that
      of Widimski are indicated.

PMID- 1018422
TI  - [Diagnosis of pulmonary hypertension with the aid of electrokymography].
AB  - Electrokymography was carried out in 198 patients with cor pulmonale and mitral
      defect with clinical signs of elevated blood pressure in the pulmonary
      circulation. The electrokymographic signs of pulmonary hypertension were
      developed, as well as those for the evaluation of the functional state of the
      myocardium of both ventricles. In making the diagnosis of elevated--pressure in
      the pulmonary artery system of special importance is the analysis of the
      electrokymogrammes of the pulmonary artery, right atrium and right ventricle, and
      the determination of the pulse wave speed along the pulmonary vessels. The study
      of the electrokymogrammes and their comparison with the clinical pattern
      permitted to classify all the electrokymographic criteria of pulmonary
      hypertension into true and relative ones, requiring verification. A
      differentiated analysis of the systolic and diastolic phases of the left and
      right ventricles was conducted. All the phases of the cardiac cycle were
      calculated with due regard of the contractions rate. The phase analysis permitted
      to assess separately the functional state of the myocardium of both halves of the
      heart. Electrokymography helped to reveal pulmonary hypertension that could be
      often diagnosed with its aid at an early stage. It permitted to diagnos an
      initial reduction of the contractile finction of the right ventricle.

PMID- 1018423
TI  - [Significance of external respiratory indices in the diagnosis of pulmonary
      hypertension].
AB  - The results of the presented study include the parameters of pulmonary
      ventilation, respiratory volumes, pulmonary diffusion, oxygen saturation of
      arterial blood in patients with mitral stenosis, aortic valve insufficiency, and
      primary forms of pulmonary hypertension, as well as the dynamics of several
      parameters of pulmonary respiration in a group of patients following an
      alleviation of their circulatory insufficiency. Some pecularities of the changes
      in the studied parameters were demonstrated with reference to the peculiarities
      of the haemodynamic shifts in the pulmonary circulation, to the nature of
      pulmonary hypertension in particular, as well as the correlation between the
      severity of the functional disorders in the pulmonary respiration system and the
      severity of circulatory insufficiency. Some pathogenetic mechanisms of the
      changes of certain pulmonary respiration parameters were analysed in the
      mentioned pathological conditions. The importance of a compound dynamic study of
      the pulmonary respiration state is emphasized for an objective assessment of the
      degree and peculiarities of the functional disorders developing in these
      conditions, and for an evaluation of the efficacy of the conducted treatment.

PMID- 1018424
TI  - [Echocardiographic signs of pulmonary hypertension].
AB  - The results of examination of patients with primary and secondary pulmonary
      hypertension by means of the echocardiographic method are presented in the
      article. Basing on the analysis of their own data and foreign literature the
      authors have set out the most informative indices of pulmonary hypertension on
      the echogram of the vulve of the pulmonary artery and the right ventricle. It has
      been noted that in the left hypertension the form of the echocardiogram of the
      left cusp of the pulmonary valve is depressed, the amplitude of the precardiac
      wave "a" increased, and the amplitude and rate of the cusp opening decreased. The
      anterior-posterior size of the right ventricle is significantly increased and a
      parodoxal movement of the interventricular septum appears with a relative
      insufficiency of the tricupsid valve.

PMID- 1018425
TI  - [Changes in the electro- and vectorcardiograms in primary vascular pulmonary
      hypertension].
AB  - A progressive elevation of the blood pressure in the pulmonary circulation in
      patients with primary vascular pulmonary hypertension results in isolated
      hypertrophy of the right-ventricle. According to electro- and vectorcardiographic
      data of the McFee--Parungao system, a significant predominance of the right
      vetricular potentials is noted, distinct reorientattion observed in those
      sections of the vectors that may reflect the process of hypertrophy and
      dilatation of the outflow tracts of the right ventricle.

PMID- 1018426
TI  - [Phonocardiogram characteristics in different forms of pulmonary hypertension].
AB  - To study the peculiarities of phonocardiogrammes in pulmonary hypertension of
      different genesis a comparison was conducted between the phonocardiographic data
      and those of heart catheterization and zonotomography. The study was conducted in
      49 normal individuals and 177 patients with various lesions accompanied by an
      elevated pressure in the pulmonary vessels. It was found that no
      phonocardiographic peculiarities inherent in pulmonary hypertension are typical
      for any of the examined entities. The common features of pulmonary hypertension
      are: 1) growing amplitude of the pulmonary component of the II sound, increasing
      parallel to the degree of hypertension (with the exception of patients with
      chronic non-specific pulmonary lesions in whom the pulmonary component of the II
      sound does not grow, in absolute figures); 2) reduction of the coefficient
      II/IIIP of the II sound components, also developing parallel to the growth of
      hypertension; 3) detection of the ejection sound on the phonocardiogramme, as
      well as of a systolic murmur of the ejection and of a diastolic murmur; 4)
      increasing indices of the IV sound recordings in primary vascular hypertension.
      Not infrequently the amplitude of the Isound is also increased in cases of
      pulmonary hypertension, although its direct relationship with pulmonary
      hypertension is hardly possible.

PMID- 1018427
TI  - [Some pressing problems concerning the interrelationship of circulation and
      respiration].

PMID- 1018428
TI  - [Primary pulmonary hypertension and the difficulties of clinical diagnosis].
AB  - An analysis of 38 patients is presented of whom 23 had primary pulmonary
      hypertension proper, 6--congenital heart diseases, and in 6 pulmonary
      hypertension was combined with chronic recurrent thrombophlebitis and
      thromboembolic episodes in the pulmonary artery system, and in 3--with
      sclerodermia. The greatest difficulties arise when primary pulmonary hypertension
      has to be clinically differentiated from some congenital heart diseases (septal
      defects and patent Botalli duct). The discreapances of clinical and anatomic
      diagnoses of primary pulmonary hypertension happen most often in cases of the
      above mentioned congenital heart diseases. Catheterization of the cardiac
      cavities is an important tool in the diagnosis of primary pulmonary hypertension
      that permits to differentiate it from congenital heart diseases.

PMID- 1018429
TI  - [Clinical and instrumental characteristics of primary high altitude arterial
      pulmonary hypertension].
AB  - The clinical pattern of primary high altitude pulmonary arterial hypertension
      observed in permanent residents of mountain regions is described. The diagnostic
      value of some non-invasive instrumental methods in primary high altitude
      pulmonary artery hypertension is analysed: electro- and vectorcardiography,
      rheopulmonography, and indirect pulmonary artery pressure determination. It is
      suggested to distinguish the labile, stable and decompensated forms of the
      disease on the basis of its clinical and functional peculiarities. The criterion
      for the initial two forms consists in the persistence of the pulmonary artery
      pressure elevation, while the latter form is established when the high altitude
      cor pulmonale gets decompensated. Functional vasoconstriction of the pulmonary
      resistive vessels was shown to play an important role in the genesis of the
      disease: the administration of 0.5 mg of nitroglycerine and a 5-minute oxygen
      inhalation caused a positive dynamics in the indices of the pulmonary rheogramme
      and a reduction of the pulmonary artery pressure, which did not reach the level
      of the plane inhabitants, though.

PMID- 1018430
TI  - [Pneumooxyhemographic method for the comprehensive study of circulation and
      respiration].
AB  - Over 3000 pneumoxyhaemogrammes were recorded in 1840 persons. Periods, types and
      criteria of pathology were differentiated in the structure of the
      pneumoxyhaemogramme. The method permits to reveal early forms of cardiovascular
      pathology. It is applicable for the examination of both normals and patients for
      early diagnosis of cardiovascular pathology, for the control of the therapeutic
      effect, and for a dynamic observation in the course of a dispensary screening.

PMID- 1018431
TI  - [Hemodynamics of the lesser and greater circulation in chronic bronchitis and
      chronic pneumonia].

PMID- 1018432
TI  - [Pulmonary circulation in ischemic heart diseases under bicycle ergometer load
      and acute strophanthin test conditions (based on data from catheterization of the
      right heart and pulmonary artery)].
AB  - On the basis of monitoring the systolic, diastolic and mean pulmonary artery
      pressur at rest, during ergometric exercises and under identical conditions
      following premedicatio with cardiac glycosides (48 measurements in 12 patients
      with ischaemic heart disease) the authors concluded on the importance of studying
      this parameter for the diagnosis of initial stage cardiac insufficiency, and on
      its high informativeness for deciding the indications for initiating therapy with
      cardiac glycosides.

PMID- 1018433
TI  - [Changes in the hemodynamic indices of the pulmonary circulation and in the
      functional state of the right ventricular myocardium in stage II hypertension
      under certain types of hypotensive therapy].
AB  - The author observed 76 patients with Stage II essential hypertension undergoing
      combined therapy with Rauwolfia serpentaria, Isobarine and Hypothiazid, 37
      patients treated with Dopegit, and 44--with Obsidan. The examined patients
      demonstrated pulmonary arterial hypertension or a tendency towards its
      development, an increasing lung-ear time interval, and a reduced functional
      capacity of the right ventricular myocardium. A direct correlation was
      established between the level of blood pressure in the general circulation and
      the pressure in the pulmonary artery and the degree of blood flow deceleration in
      the lung-ear interval. Combined therapy results in a reduction of the elevated
      blood pressure not only in the general, but also in the pulmonary circulation.

PMID- 1018434
TI  - [Pulmonary hemodynamics in the immediate and late periods after mitral
      commissurotomy in children, based on rheopulmonographic data].
AB  - On the basis of the analysis of rheopulmonograms the condition of the pulmonary
      blood flow was studied in 35 children with mitral stenosis prior to operation and
      on the 20--30th day and 6 months after the operation. There was revealed partial
      normalization of the pulmonary blood flow in patients with "pure" stenosis and
      insufficient effectiveness of commissurotomy in persons with concomitant mitral
      valve insufficiency.

PMID- 1018435
TI  - [Clinical diagnosis and prognosis of the course of congenital heart defects with
      pulmonary stenosis].
AB  - An analysis of 433 observations is presented (164 cases of isolated pulmonary
      stenosis, 132 cases of its combination with atrial septal defect, and 137--with
      ventricular septal defect), the patients being 1 year 1 month to 36 years old,
      and the form of their heart disease being verified during surgery on a "dry"
      heart. The mentioned diseases were classified into 3 groups according to the
      tactical importance of the pulmonary stenosis. Haemodynamic studies in patients
      with pulmonary stenosis and an intact ventricular septum have demonstrated that
      with age right-ventricular hypertension progresses the faster the greater the
      pulmonary artery valve is stenosed. A combination of a valvular stenosis with a
      large ventricular communication is accompanied by a levelling of the pressure in
      both ventricles, its absolute figures being somewhat higher in patients over 16
      years of age.

PMID- 1018436
TI  - [Intracardiac hemodynamics after pulmonary artery valvuloplasty].
AB  - Studies of intracardiac haemodynamics were conducted in 30 patients subjected to
      valvuloplasty of the pulmonary artery valve. The method of continuous (for
      several days) right ventricle and pulmonary artery catheterization was employed.
      The isometric hyperfunction of the right ventricle was found to persist following
      the elimination of pulmonary valve stenosis. Myocardial insufficiency then
      develops that requires intensive cardiac therapy.

PMID- 1018437
TI  - [Status and main trends of development of surgical service in the Ukrainian SSR
      in the 10th Five-Year-Plan].

PMID- 1018438
TI  - [Correction of metabolic disorders and acid-phase equilibrium in diffuse purulent
      peritonitis].

PMID- 1018439
TI  - [Disorder of protein metabolism in acute peritonitis].

PMID- 1018440
TI  - [Rectal fistulas in children and their treatment].

PMID- 1018441
TI  - [Early diagnosis of inflammatory complications developing in the pleural cavity
      after transthoracic operations].

PMID- 1018442
TI  - [25-year experience in surgical treatment of goiter in Rovno district].

PMID- 1018443
TI  - [Surgical treatment of superficial varicose veins complicated by trophic ulcers
      and thrombophlebitis].

PMID- 1018444
TI  - [Interposition of dolicho-megasigmoid].

PMID- 1018445
TI  - [Strain-induced diseases of the femur in young soldiers].

PMID- 1018446
TI  - [Treatment of various diseases of the limb stumps by alternating magnetic field].

PMID- 1018447
TI  - [Acute gynecologic diseases erroneously diagnosed as acute appendicitis].

PMID- 1018448
TI  - ["Herniotomy" in syphilitic bubo].

PMID- 1018449
TI  - [Anaphylactic shock caused by intravenous injection of isotonic solution of
      sodium chloride].

PMID- 1018450
TI  - [Analysis of causes of late hospitalization of patients with acute surgical
      diseases of the abdominal organs].

PMID- 1018451
TI  - [Glycemic curves in patients with erroneously performed gastroileoanastomosis
      during gastric resection].

PMID- 1018452
TI  - [Local changes of blood flow and available oxygen in the brain after severe
      cranio-cerebral injury].

PMID- 1018453
TI  - [Certain characteristics of brain injury in fracture of the base of the skull].

PMID- 1018454
TI  - [Morphological characteristics of wound healing after use of dressings with
      actinated sunflower oil].

PMID- 1018455
TI  - [Complex treatment of diffuse purulent peritonitis].

PMID- 1018456
TI  - [Hernia of the xiphoid process].

PMID- 1018457
TI  - [Device for removal of thrombi].

PMID- 1018458
TI  - [New symptom in the diagnosis of strangulated inguinal and femoral hernias].

PMID- 1018459
TI  - [Accidents and lethality in ocular surgery (author's transl)].
AB  - The mortality and morbidity rates in eye surgery are low as compared to other
      surgical specialities. The lethality rate is not, however, as low as one might
      suppose if one follows the fate of patients which require postoperative transfer
      into other (non ophthalmologic) clinics. The morbidity rate differs markedly,
      depending on whether a local or general anesthetic is used. Following local
      anesthetics, the incidence of pulmonary emboli was 2.4 times greater, and
      thrombophlebitis twice as common as with general anesthetics, whereas cardiac
      complications occurred more frequently with general anesthetics. Pre- and
      postoperative measures are presented which have proven useful in the reduction
      and prevention of such mishaps.

PMID- 1018460
TI  - [Trepanation with scleral flap (Elliot-Fronimopoulos) in acute narrow-angle
      glaucoma (author's transl)].
AB  - 120 eyes with acute closed angle glaucoma were operated by goniotrepanation
      (Elliot-Fronimopoulos). The follow-up controls showed excellent results.
      Especially the quick restoration of the anterior chamber and the increase in its
      depth must be emphasized. There are very rare complications and the resulting eye
      pressure is normal.

PMID- 1018461
TI  - [Exposure of the ciliary body. A new operative method for treatment of
      irreversible angle closure glaucoma and aphakiaglaucoma (author's transl)].
AB  - In various forms of glaucoma with an unfavorable prognosis an operation developed
      by us in the Eye Clinic of the University of Graz since 1972, ciliary body
      exposure, has been performed. Up till now 68 such operations have been performed.
      In 63.2% of cases we had a good result. Technique, indications, post-operative
      care an complications are discussed.

PMID- 1018462
TI  - [Silicon sponge: ultrastructural examinations in chronic infection (author's
      transl)].
AB  - Ultrastructural examinations of a silastic sponge implant (which was removed with
      the clinical diagnosis rejection against the silicon material) revealed massive
      infiltration of so called apothogenic bacteria and macrophages. The results of
      this examination support the idea that in most of the cases with symptoms of
      inflammation, there is not a rejection against the sponge material itself but
      acute or chronic bacterial infection. In the bradytrophic area of the sponge
      socalled apathogenic bacteria may grow and lead to considerable reactions,
      because antibodies are decreased.

PMID- 1018463
TI  - [Running time of ultrasound in the distal portion of the optic nerve (author's
      transl)].
AB  - In 160 cross sectional ultrasonograms of normal optic nerves the double running
      time of ultrasound in 4.5-5 musec. The standard deviation is up to 1 musec. The
      conditions of measurement and the typical ultrasonographic patterns are
      discussed. These results are of value in the differential diagnostic of bilateral
      optic nerve lesions. Increased running time of ultrasound could be found in
      papilloedema due to neuritis, raised intracranial and intraorbital pressure, and
      in trauma and tumor. It can be decreased in optic atrophy.

PMID- 1018464
TI  - [The behaviour of plastic catheters within the anterior segment of rabbit's eyes
      (author's transl)].
AB  - The location and tolerance of plastic tubes (2 polyvinyl and 7 silicone
      respectively) within the anterior segment of the eyes of nine rabbits were
      observed for periods of 3 to 9 months. In 3 animals the tube was held in place
      with a single (scleral) suture: the catheter was ultimately totally displaced
      into the anterior chamber. In the remaining 6 cases a second (corneal) suture was
      applied. As a result only a limited migration of the silicone catheters was
      observed. The suprascleral as well as the intracameral portions of the tubes were
      well tolerated. Even the catheters that had migrated completely into the anterior
      chamber did not cause any inflammatory reaction.

PMID- 1018465
TI  - [Choroid neurilemmoma. Considerations for clinical differential diagnostics].
AB  - A report is given on an extremely rare case of neurilemmoma of the choroid and
      observations are made on the difficult differential diagnosis of malignant
      melanoma. Clinical diagnosis and treatment apart from enucleation, was
      impossible. The recognition of the nature of this tumor could be made only on
      histological examination.

PMID- 1018466
TI  - [Results of a glaucoma mass screening program (author's transl)].
AB  - During a so called "glaucoma-week" the intraocular pressure of 4661 persons was
      measured and the statistics obtained were evaluated according to the spss
      program. The mean value of the intraocular pressure was 17.18 mm Hg, the standard
      deviation +/-3.78 mm Hg. The frequencies of various pressure values were in
      accordance with a Gaussian distribution up to 21 mm Hg. For higher applanation
      scores a deviation from the Gaussian line became obvious, increasing in intensity
      with age. Therefore a subpopulation is postulated consisting of persons with
      diabetes, arteriosclerosis or family history of glaucoma.

PMID- 1018467
TI  - [Ektoprosthesis with a synchronically movable eyelid (author's transl)].
AB  - An ektoprosthesis with a synchronically movable, electronically controlled eyelid
      has been developed. A suitable trigger-signal is derived from the movement of the
      natural contralateral eyelid. The miniaturized electronic processing unit is
      intergrated into the spectracle frame. The artificial eyelid is moved by an
      electromagnet situated in the orbital cavity.

PMID- 1018468
TI  - [Experiences in the therapy of acute glaucoma with Miopos-eye ointment "stark"
      (POS) in the surgery (author's transl)].
AB  - The author demonstrates 5 cases of acute glaucoma. In one of them (case 4). the
      i.o. pressure of 60 mm Hg appl. was normalized only by the above mentioned
      ointment combination of Pilocarpin/Physostigmin; the remaining patients received
      in addition intravenous injections of 500 mg Acetazol-Nitrium, but it seemed
      retrospectively that the latter was not necessary.

PMID- 1018469
TI  - [Late complications with anterior chamber lenses (author's transl)].
AB  - 6 intraocular lenses (type Dannheim) which had given good optical results after
      implantation had to be removed after 7-19 years because of keratopathy, iritis,
      and secondary glaucoma. The most important finding was an advanced arrosion of
      the supporting supramide loops. This often caused breaking of the loops and was a
      major factor for late complications.

PMID- 1018470
TI  - [Complete or peripheral iridectomy in acute glaucoma? (author's transl)].
AB  - The re-examinations of 28 complete sector and 27 peripheral iridectomies,
      performed because of acute glaucoma, showed an equally good regulation of IOP
      from both methods, even in longstanding cases (stadium III of Leydhecker) and
      when an operation during an attack is necessary. The postoperative reduction in
      vision mainly caused by cataract, was seen more frequently after sector
      iridectomy. In acute glaucoma the peripheral iridectomy as the less extensive and
      less severe procedure is to be preferred to the sector iridectomy with the
      exception, that an optical iridectomy is indicated.

PMID- 1018471
TI  - [Assessment of eye damage in private accident insurance (author's transl)].
AB  - Following a fundamental sentence of the German Supreme Court eye damage affecting
      both eyes - actual or preexisting - has to be judged under the aspect of
      coordinating function. So the usual practice of isolated judgement of each eye
      can only be performed in unilateral damage associated with complete function of
      the other eye.

PMID- 1018472
TI  - [A short observation on the cause of myopia (author's transl)].
AB  - The increased excretion of acid mucopolysaccharides in the urine of patients with
      advanced myopia is indeed relevant for understanding the chemical processes in
      the sclera during this period, but it does not say anything concerning the
      genesis of myopia as such. This is due more to an infiltrative malformation of
      the eyeball and the optic nerve. The behaviour of the connective tissue can also
      be due to infiltration, or contrariwise induced from parenchyma at the
      appropriate time. Hence therapeutic possibilities can hardly be deduced from the
      chemistry of the sclera. Abnormally small corneas in people with high myopia
      point to a genetic connection between such eyes and "true" microphthalmos with
      orbital cyst.

PMID- 1018473
TI  - The etiology of transmissible murine colonic hyperplasia.
AB  - The etiology of a transmissable colonic mucosal hyperplasia of mice was
      investigated. Hyperplasia was produced in mice inoculated with unfiltered colonic
      suspension from affected mice, but infectivity was lost after passage through a
      0.45 mum filter. The etiologic agent was subsequently identified as a variant of
      Citrobacter freundii. The organism induced colonic mucosal hyperplasia when
      inoculated into germfree mice, and it was recovered in pure culture from the
      affected animals.

PMID- 1018474
TI  - Vaginal septa in mice: incidence, inheritance, and effect on reproductive,
      performance.
AB  - Dorso-ventral vaginal septa were observed in 38% of the recently weaned BALB/cJ
      female mice in the production colony at The Jackson Laboratory. The frequency of
      septa in two other BALB/c substrains and eight different inbred strains ranged
      from 0 to 8%. The vaginal anomaly was similar regardless of genetic background
      although individual variations were observed. The remainder of the reproductive
      tract was normal. Microscopically, the septum consisted of a fibrous partition
      covered by normal epithelium. Genetic analysis was undertaken by outcrossing
      septate BALB/cJ females to C57BL/6J, DBA/2J, or BALB/cBy males. Examination of
      female F1 and F2 progeny indicated more than one recessive gene was involved and
      genetic background influenced expression of these genes. Reproductive performance
      of septate and nonseptate BALB/cJ females was compared using several criteria.
      Fewer septate females were fertile, but the fecundity of fertile septate females
      was not affected.

PMID- 1018475
TI  - Effect of repeated halothane anesthesias on Syrian hamster lung lipids.
AB  - Sixteen adult Syrian hamsters were exposed 33 times over a 19-day period to
      enough halothane to induce a deep surgical plane of anesthesia. The exposures
      caused no significant change in the total amount of lipid in the exposed lungs;
      however, the percentage of neutral lipid due to cholesterol increased from 29 +/-
      5% to 43 +/- 7% while the percentage of free fatty acid decreased from 33 +/- 3%
      to 22 +/- 5%. Among the phosphoglycerides, there was a slight shift toward more
      phosphatidyl choline and less phosphatidyl serine, phosphatidyl glycerol, and
      phosphatidyl ethanolamine.

PMID- 1018476
TI  - Hemoglobins of the opossum (Didelphis marsupialis). II. Polymorphism;
      electrophoretic and chromatographic observations.
AB  - Eighty-five adult opossums (Didelphis marsupialis) were examined for variation of
      hemaglobin by means of electrophoresis and column chromatography. A single
      hemoglobin was found in 83 animals while two hemoglobins were observed in two
      animals. The results of the chromatography studies suggested that the
      polymorphism was due to primary sequence differences in the alpha chain. Attempts
      to confirm this result by hybridization with human or canine hemoglobins were
      unsuccessful. The polymorphism was found not to be due to size differences and
      further investigation into its genetic basis was suggested.

PMID- 1018477
TI  - Semen volume and sperm concentration in the ferret (Mustela putorius).
AB  - Semen was obtained from 40 of 62 attempted electro-ejaculations of nine
      anesthetized male ferrets. The ejaculations were performed using a bi-polar
      rectal electrode and an electrical stimulus of about 4 V and 0.35 mA applied for
      approximately 4 seconds and repeated at 10-second intervals. The mean number of
      stimuli required to obtain an ejaculation was 12.3. The spermatozoa concentration
      per mm3 ranged from 0.07 x 10(6) to 1.98 x 10(6) with a mean of 0.62 x 10(6). The
      mean number of spermatozoa per ejaculate was 16.35 x 10(6) and the mean volume of
      semen per ejaculate was 0.026 ml.

PMID- 1018478
TI  - Changes in anticoagulation in dogs assayed by three methods.
AB  - As a preliminary to a membrane oxygenator study, a study was made of clotting
      indices in dogs and their intercorrelation and relationship to human data. The
      most useful criterion for monitoring coagulation in experimental extracorporeal
      systems was sought. Linear regression and correlation analysis indicated that
      activated partial thromboplastin time (APTT) predicted whole blood clotting time
      with a correlation of 0.77 (p less than 0.01). Changes in the APTT with time
      after heparinization were similar to those previously reported in man, making the
      animal model an acceptable one for use in developing extracorporeal systems such
      as the membrane oxygenator. When blood activated recalcification time (BART),
      APTT, and whole blood clotting time (WBCT) assays were compared on the basis of
      applicability to studies of extracorporeal support, the APTT and the BART assays
      proved superior to the WBCT assay due to their reduced variability and increased
      speed of determination. The variability of the BART assay was the lowest, and its
      sensitivity was the same as the APTT assay. The principal drawback to the BART
      assay was not experienced in this study; that is, its dependence on adequate
      platelet levels which are unpredictable in extracorporeal systems.

PMID- 1018479
TI  - Comparison of hemagglutination inhibition pregnancy tests in the chimpanzee and
      the orangutan.
AB  - A hemagglutination inhibition pregnancy test (Subhuman Primate Pregnancy Test),
      based on antiserum to the beta-subunit of ovine luteinizing hormone was evaluated
      for use in the chimpanzee and orangutan. The test was shown to give earlier
      indication of pregnancy in both species that two sensitive tests currently
      available for use in man (the Pregnosticon Accusphere Test and the UCG-Test). A
      comparison of sensitivity to chimpanzee chorionic gonadotropin was performed. The
      Subhuman Primate Pregnancy Test was 10 and 15 times as sensitive as the UCG-Test
      and the Pregnostican Accusphere Test respectively.

PMID- 1018480
TI  - A device for the cutaneous exteriorization of chronic intravascular catheters.
AB  - A device has been designed which permits the cutaneous exteriorization of
      chronically implanted intravascular catheters. From one to three catheters may be
      exteriorized for withdrawing blood samples or for connecting to a pressure
      transducer. The device is uniquely suited for studying animals in a conscious and
      unrestrained state such as during exercise.

PMID- 1018481
TI  - Exteriorized carotid-jugular shunt for hemodialysis of the goat.
AB  - A surgical technique was developed for the establishment of a permanent
      exteriorized artificial shunt between a carotid artery and a jugular vein of a
      goat. The shunt allowed continuous hemodialysis with an artificial kidney for
      hours or a prosthetic unit for days and intermittent experimental use of the
      animal for months.

PMID- 1018482
TI  - Particulate matter induced periorbital abscess in gnotobiotic athymic nu/nu
      (nude) mice.

PMID- 1018483
TI  - A simple technique for kidney perfusion in the mouse.

PMID- 1018484
TI  - Effect of overnight fasting of young rats on water consumption, body weight,
      blood sampling, and blood composition.

PMID- 1018486
TI  - Eroticism in infancy and childhood.

PMID- 1018485
TI  - Trichophyton mentagrophytes infection in rabbits successfully treated with a
      polyvinyl iodine solution.

PMID- 1018487
TI  - The home situation and the homosexual.

PMID- 1018488
TI  - Three cases of genital self-surgery and their relationship to transexualism.

PMID- 1018489
TI  - Vasectomy: its effect upon marital stability.

PMID- 1018490
TI  - Comparative psychiatric status of male applicants for sexual reassignment surgery
      jejunoileal bypass surgery, and psychiatric outpatient treatment.

PMID- 1018491
TI  - Status inconsistency effects on sexual liberalness.

PMID- 1018492
TI  - Sex therapy in Australia.

PMID- 1018493
TI  - Some paediatric liver diseases encountered in Singapore.

PMID- 1018494
TI  - Clinical features in children of infection caused by the influenza A2 variant
      A/Victoria/3/75.

PMID- 1018495
TI  - Early diagnosis of tuberous sclerosis.

PMID- 1018496
TI  - Changing patterns of paediatric diseases in Singapore.

PMID- 1018497
TI  - Hydrocephalus in infancy.

PMID- 1018498
TI  - [Perspectives of intrauterine contraception].
AB  - The author describes the current research in intrauterine contraception. It is
      directed in two ways: to improve the design of inert devices and to construct an
      optimal bioactive IUD. The design of the inert IUD should be adapted as much as
      possible to anatomical and functional conditions of the uterus. In developing new
      bioactive devices it is ained at finding the optimal dosage of metals and
      hormones as well as the new material acting as carriers of bioactive substances.
      With new constructions and the determination of the optimale dosage of
      antifertile and antifibrinolitic substances it is hoped to reduce three main
      insufficiences of intrauterine contraception: bleeding, expulsion and pregnancy.

PMID- 1018499
TI  - [C-reactive protein in inflammatory processes of the female genital organs].
AB  - C-reactive protein (CRP) was investigated in 202 women: in 20 women with acute
      non-specific inflammation and the presence of different bacteria (Streptococcus
      pyocyaneus, Enterococcus, Escherichia colli, Proteus), in 12 women with confirmed
      genital tuberculosis, in 66 women with the chronic inflammation of genital
      organs, and in 104 women with normal genital findings. In all patients with acute
      inflammations CRP was positive. It was highly positive in those with elevated
      temperature and sedimentation values. CRP was also positive in the group of women
      with genital tuberculosis. A quantitative analysis mainly gave low CRP values in
      these women. The CRP values correlated with the Middelbrook-Dubos reaction titer.
      In women with chronic inflamations and those with a normal genital finding CRP
      proved negative. In women with CRP was positive even when the antistreptolysin
      caused by streptococci but also for those caused by other agents. It is concluded
      that C-reactive protein is a useful indicator of the activity of different
      inflammatory processes and that it may be affected by different drugs.

PMID- 1018500
TI  - [Surgical interventions in the digestive tract during gynecological and obstetric
      operations].
AB  - At the University Hospital Department of Gynecology and Obstetrics in Novi Sad,
      from 1945 to 1975, there were 17,362 major gynecological (laparotomies and
      vaginal) operations and cesarean sections. During these operations 0.11% of
      patients (19 women) had accidental injuries of the digestive organs (small or
      large intestines, or the mesenterium). All these injuries were treated during one
      and the same surgical act (sutures or resections of the small or large
      intestines). In 39 (0.22%) women, owing to a wrong preoperative diagnosis,
      laparotomy revealed inflammatory changes or tumours of the digestive tract which
      required primary surgical treatment: resection of the small or large intestines
      or the treatment of the perforated or gangrenous appendix, etc. Among the
      operations performed there were also 944 appendectomies and 65 hernitomies (in
      the course of gynecological operations or, less frequently, as separate
      interventions), 13 intestinal injuries during legal and illegal abortions, as
      well as 9 other surgical interventions (splenectomies, surgical treatment of the
      ileus, etc). In a total of 1079 pelvic operations also operations of the
      digestive tract were jointly made, which makes 6.46% of all major gynecological
      operations and cesarean sections. Obviously, it is not rare that the gynecologist
      obstetrician faces situations requiring surgical interventions in the abdominal
      organs along with those in the genital tract. This raises the question of how
      much the gynecologist-obstetrician should be qualified also for abdominal surgery
      and urology, which is particularly important from the point of view of
      postgraduate education of gynecologists-obstetricians. In this country there are
      still certain dilemmas concerning this question.

PMID- 1018501
TI  - [Intrauterine growth and its variations in different populations].
AB  - Intrauterine growth of newborns in the population of Novi Sad shows markedly low
      values in the median and the tenth and ninetieth percentiles between the 35th and
      the 37th gestation week. These data suggest a higher pathology of gravidity in
      the third trimester and inadequate antenatal care. After the 38th gestation week
      the intrauterine growth curve shows an extremely positive trend. In the tenth
      percentile the curve for male newborns exceeds the value of the tenth percentile
      for newborns in Prague, Pecs, Denver, and Aberdeen.

PMID- 1018502
TI  - [Incidence of aplasia of the umbilical artery in fetuses with intrauterine
      retardation].
AB  - The author analysed the occurrence of the aplasia of the umbilical artery in 320
      umbilical cords of fetuses with intrauterine retardation and in 225 umbilical
      cords of normal fetuses and a normal course of pregnancy used as controls.
      Aplasia of the umbilical artery in umbilical cords of fetuses with intrauterine
      retardation was found in 5.93% and in the control group in 0.44% of cases (P less
      than 0.05). Fetuses with intrauterine retardation and aplasia of the umbilical
      artery showed a velamentous insertion of the umbilical cord in 31.57% of cases,
      an approximate duration of pregnancy of 36 weeks and 5 days, and the mean birth
      weight of 2250 +/- 2 S.D. 420 g. Out of 19 fetuses with intrauterine retardation
      and aplasia of the umbilical artery, 6 had congenital anomalies which in 50% of
      cases could not be detected by external examination. Perinatal mortality of
      fetuses with intrauterine retardation and aplasia of the umbilical artery proved
      to amount to 368.43% and of fetuses in the control group to 8.88% (P less than
      0.05).

PMID- 1018503
TI  - [Induction of ovulation by antiestrogens].
AB  - The mode of action of antioestrogens is in blocking oestrogen receptors in the
      target cell cytoplasm. For this reason they can be used only in cases where basal
      oestrogen activity is present. We treated two groups of patients with
      antioestrogens. In the first group (30 patients) with oligomenarrhoe and an
      ovulatory sterility we had 15 pregnancies. In the second group of  26 patients
      with amenorrhoe and sterility we had 4 of pregnancies and 12 menstruations. In
      this very small group a child with enterocoele was born to a 38-years old
      patient. All other patients' children were normal. Out of 19 pregnancies 4 were
      completed by early abortion.

PMID- 1018504
TI  - [Unusual form of dystocia - constriction ring].
AB  - A rare form of distocia, the constriction ring, is presented. The etiology of
      this kind of distocia is vague and the diagnosis complicated, almost invariably
      made only during the cesarean section itself. The increased basal tonus or
      uterine musculature, always present in this kind of distocia, would indicate the
      administration of tocolytics but there is too little experience at hand so far.

PMID- 1018505
TI  - [Cancer of the stomach, pregnancy and labor].
AB  - The authors describe a case of gastric carcinoma coupled with pregnancy, the only
      such case they encountered in 80,064 deliveries over a period of 30 years. The
      pregnancy was complicated by pronounced anemia and general weakness. By
      administering roborants, antianemic therapy, and blood transfusion to improve the
      patient's general condition, the pregnancy was completed by the birth of a
      clinically healthy at-term live child, weighing 3150 g. The patient lived only 6
      months after delivery.

PMID- 1018506
TI  - [Cervical pregnancy].
AB  - Cervical pregnancy is still a diagnostic and therapeutic problem. What is
      important in its treatment is to preserve women's fertility but very often more
      radical surgical interventions cannot be avoided. Two cases of cervical pregnancy
      are presented. In one case only the cervix was amputated, so that the women's
      fertility was preserved. In the other patient the uterus had to be removed
      because, after attempts to apply more conservative surgical treatment, intense
      bleeding was threatening the woman's life.

PMID- 1018507
TI  - [Single oral administration of Fasigyn in the treatment of genitourinary
      trichomoniasis].
AB  - In 35 women and 30 men with Trichomoniasis one day therapy with Fasigyn was
      applied. 8-th day after treatment Trichomonas vaginalis was found in only three
      women and two men, but they were also curred by the repeated treatment. Side
      effects were not observed. Authors opinion is that this kind of therapy is
      specially acceptable in women with metrorhagia and those in preoperative care.

PMID- 1018508
TI  - Byssinosis and airway responses due to exposure to textile dust.

PMID- 1018509
TI  - Effect of low concentrations of sulfur dioxide on respiratory function in man.

PMID- 1018510
TI  - Carboxyhemoglobin levels in fire fighters.

PMID- 1018511
TI  - Reaction following allergen inhalation via mouth and via tracheal tube on dogs.

PMID- 1018512
TI  - Lung volumes in healthy boys and girls, 6 - 15 years of age.

PMID- 1018513
TI  - Obstruction of small airways in patients after acute myocardial infarction.

PMID- 1018514
TI  - [Closing volume and resistance-lung-volume-relationship in simple coal worker's
      pneumoconiosis (author's transl)].

PMID- 1018515
TI  - [Disorders of hemostasis in acute leukemias].

PMID- 1018516
TI  - [Possibilities of treatment and rehabilitation of gynecologic patients with
      thermomineral water and peloids of Ilidza baths].

PMID- 1018517
TI  - [Quantitative analysis of early phases of brain scintigram by means of
      radioactive pertechnetate-Tc 99m].

PMID- 1018518
TI  - [Analysis of the work of the glaucoma department of the ophthalmologic clinic in
      Sarajevo from May 1974 to the end of the year 1975].

PMID- 1018519
TI  - [Our experience in the cava catheter introduction by means of subclavian vein
      puncture].

PMID- 1018520
TI  - [Immunosuppressive therapy - review of up-to-date experience in the world and in
      our country].

PMID- 1018521
TI  - [Epidemiology and current accomplishments in postinfective prevention of rabies].

PMID- 1018522
TI  - [Review of our patients with leptospirosis accompanied by jaundice syndrome].

PMID- 1018523
TI  - [Carcinoma of the breast].

PMID- 1018524
TI  - Brief guide to office counseling: marihuana and sex.

PMID- 1018525
TI  - [The "extinct" liver. Major hypofixation of colloidal gold in scinigraphy of
      alchoholic cirrhosis and hepatitis].

PMID- 1018526
TI  - [The acute abdomen in cirrhosis].

PMID- 1018527
TI  - [Pseudoneoplastic sigmoid stenosis caused by endometriosis].

PMID- 1018528
TI  - [Familial Mediterrean fever. Apropos of 7 Greek cases].

PMID- 1018529
TI  - [Pribram's test and severe suppurative angiocholitis with miliary abscesses of
      the liver].

PMID- 1018530
TI  - Omental torsion.

PMID- 1018531
TI  - [Hepatic complications of mucoviscidosis].

PMID- 1018532
TI  - [New therapeutic contribution in proctology: esberiven].

PMID- 1018533
TI  - [Lysine acetylsalicylate administered parenterally. Action on the gastric juice].

PMID- 1018534
TI  - [Effects of Panthenol on the intestinal electrical activity].

PMID- 1018535
TI  - [The role of mucilages in the treatment of constipation].

PMID- 1018536
TI  - [Hepatic metabolism of estrogens and progesterone].

PMID- 1018537
TI  - [Changes in carbohydrate and lipid metabolism and biliary function induced by
      estro-progestagens and during pregnancy].

PMID- 1018538
TI  - [Cholestasis of pregnancy].

PMID- 1018539
TI  - [Jaundice caused by oral contraceptives].

PMID- 1018540
TI  - [The pill and biliary lithiasis].

PMID- 1018541
TI  - [Tumors of the liver and hepatic purpura associated with the administration of
      oral contraceptives].

PMID- 1018542
TI  - [Liver nodules, purpura and the pill. Pathologic anatomy].

PMID- 1018543
TI  - [Ultrastructure of the liver in the course of taking oral contraceptives].

PMID- 1018544
TI  - [Budd-Chiari syndrome and oral contraceptives].

PMID- 1018545
TI  - [Difficulties of interpretation of the role of estrogens-progestagens in the
      etiology of venous theromboses. Apropos of a case of Budd-Chiari syndrome].

PMID- 1018546
TI  - [Budd-Chiari syndrome and oral contraceptives].

PMID- 1018547
TI  - [Drug vigilance and oral contraceptives].

PMID- 1018548
TI  - [Whole body tomometry: preliminary results in exploration of the liver and future
      prospects].

PMID- 1018549
TI  - [Antibiotic therapy and bacterial dysmicrobism].

PMID- 1018550
TI  - [L-asparaginase and L-glutaminase activity in staphylococci].

PMID- 1018551
TI  - [Biochemical and toxic properties of staphylococci isolated from postpartum
      women].

PMID- 1018552
TI  - [Capability of starved staphylococci to grow in serum].

PMID- 1018553
TI  - [Partial amino acid sequence of the tetanus toxoid protein as determined by the
      Edman method and with dansyl chloride].

PMID- 1018554
TI  - [Immunoconglutinin in sera of patients with influenza].

PMID- 1018555
TI  - [Effect of various phosphoorganic pesticides on the function of human fibroblasts
      in vitro. IV. Effect on acid phosphatase, fats and the rate of CPE development].

PMID- 1018556
TI  - [Autoradiographic localization of the nucleic acid synthesis in Cysticercus
      cellulosae (Cestoda)].

PMID- 1018557
TI  - Pronominal usage, cohesion and explicitness in working-class speech: towards an
      evaluative technique.

PMID- 1018558
TI  - The relationship between self-rating of expressed inclusion and speaking time.

PMID- 1018559
TI  - Acoustic study of /i,u/ in the Spanish diphthong.

PMID- 1018560
TI  - Frequency and availability in the encoding of spontaneous speech.

PMID- 1018561
TI  - A normative study of children's listening rate preferences.

PMID- 1018562
TI  - The duration of intervocalic stops in Ceylon Tamil.

PMID- 1018563
TI  - Elicited imitation and production of language by severely subnormal children.

PMID- 1018564
TI  - The effect of mandibular nerve block upon the speech of four-year-old boys.

PMID- 1018565
TI  - Language and play: a study of the relationship between functions and structures
      in the language of five year old children.

PMID- 1018566
TI  - Facilitating the disappearance of perceptual error to the Poggendorff illusion.

PMID- 1018567
TI  - [Cytological diagnosis of pulmonary carcinoma in the 2-year period 1974-1975 in
      Perugia].

PMID- 1018568
TI  - [Alcoholic myocardiopathy and sudden death].

PMID- 1018569
TI  - [Treatment of malignant tumors].

PMID- 1018570
TI  - [Progressive hypoplasia of the thymus and spleen of PM/Se mice with congenital
      polycystic kidney].

PMID- 1018571
TI  - [Nephrotic syndrome in rats due to adriamycin chlorhydrate].

PMID- 1018572
TI  - [Functional conditions of the respiratory system and work site pollution. III.
      Relationships between "risk indicators" and "respiratory risk" in a chemical
      industry (author's transl)].
AB  - The results are reported of a retrospective study carried out by the authors on
      717 workers of a chemical industry whose exposure was diversified and quantified
      through a work environment survey. A comparison between "risk indicators" and
      both objective (respiratory function changes) and subjective (chronic
      bronchopneumopathy symptoms) "risks" showed a significant probability of the
      causal role played by work environment pollution in respect of the repiratory
      changes found by the authors.

PMID- 1018573
TI  - [Lead poisoning hazard in pewter manufacturing industry and in art bronze
      foundries (author's transl)].
AB  - Two manufacturing processes are reported by the authors, which proved to be
      sources of lead poisoning hazard, due to the presently employed row materials.
      The results of a survey performed in 50 pewter manufacturing workers, as well as
      in 16 workmen involved in artistic bronze melting, are also reported. The
      inspection of the manufacturing processes made it possible to find out the poison
      sources in both the above mentioned types of industry.

PMID- 1018574
TI  - [Considerations and remarks on new list of occupational diseases in industry and
      agriculture].

PMID- 1018575
TI  - [Liver dye metabolism and constitutional indocyanine green retention syndrome in
      Japan (author's transl)].
AB  - Some recent studies from Japan on liver dye metabolism are presented. Special
      attention has been given to 17 cases of constitutional indocyamine green
      retention syndrome. This syndrome consists of marked ICG-retention and normal BSP
      excretion. Other liver function tests such as enzymes or serum fractions are
      normal. In liver biopsy specimens there are no significant abnormal findings. The
      cause of the syndrome is still unknown but disturbance of passage through the
      membrane is considered. So far, this syndrome has only been noted in Japan.

PMID- 1018576
TI  - [The present state of cholelithiasis research in Japan (author's transl)].
AB  - Research on cholelithiasis in Japan deals with such different aspects as
      development and composition of gallstones, geographical distribution of the
      disease, intrahepatic formation of gallstones, diagnostic and surgical
      procedures. This paper presents results on these current research topics.

PMID- 1018577
TI  - [Diagnostic procedures in congenital dilatation of the bile ducts (author's
      transl)].
AB  - A report is given of 29 cases with congenital dilatation of the bile ducts, and
      the value of different diagnostic procedures is discussed. Histology in
      combinations with clinical symptoms allows the diagnosis in cases with
      microhamartoma or with congenital fibrosis of the liver. Sonography is the most
      important procedure in the diagnosis of cysts of the liver (solitary cysts or
      polycystic conditions); it may be complemented by peritoneoscopy if diagnosis
      cannot be established with certainty by echogramm. If segmental dilatation of
      intrahepatic bile ducts (Caroli's disease) is suspected, intravenous
      cholangiography ought to be the first diagnostic step. A more reliable diagnostic
      procedure is endoscopic retrograde cholangiography (ERC) in theses cases; if ERC
      does not help, percutaneous transjugular cholangiography may be indicated. In
      establishing the diagnosis of cysts of the choledochus and of intra- plus
      extrahepatic dilatations of the bile duct systems sonography ought to be used in
      the first place; the method of choice in these latter conditions however is the
      ERC.

PMID- 1018578
TI  - [Torsion of the gallbladder (author's transl)].
AB  - The torsion of the gallbladder is a rare disease. A case of torsion of the
      gallbladder is reported who came to surgery under the diagnosis of acute
      appendicitis in an elder person. Factors facilitating torsion of the gallbladder
      are discussed. The only form of therapy is immediate cholecystectomy.

PMID- 1018579
TI  - [Some experience in the treatment of bronchus and lung carcinoma (author's
      transl)].

PMID- 1018580
TI  - [The immune response of patients with visceral lupus erythematosus treated with
      corticosteroids (author's transl)].

PMID- 1018581
TI  - [On the etiopathogenesis and clinical picture of congenital nystagmus (author's
      transl)].

PMID- 1018582
TI  - [An unusual hand and foot malformation (author's transl)].

PMID- 1018583
TI  - [Arterial brain aneurysm as the most frequent cause of spontaneous subarachnoid
      hemorrhage (author's transl)].

PMID- 1018584
TI  - [Enteroclysm (author's transl)].

PMID- 1018585
TI  - [Innovations in physical diagnostics and therapy (author's transl)].

PMID- 1018586
TI  - [Modern prevention of cerebral palsy (author's transl)].

PMID- 1018587
TI  - [Muscle testing (author's transl)].

PMID- 1018588
TI  - [Rehabilitation of polytraumatized patients (author's transl)].

PMID- 1018589
TI  - [Natural medicinal substances used for therapeutic purposes with special regard
      to sea peloids-limans (author's transl)].

PMID- 1018590
TI  - [Medical report in Croatian Alpinist expedition to Andes].

PMID- 1018591
TI  - [Surgical treatment of secondary lung tumors (author's transl)].

PMID- 1018593
TI  - [Geriatric surgery (author's transl)].

PMID- 1018592
TI  - [Cytologic changes in the CSF suring the course of viral serous meningitis
      (author's transl)].

PMID- 1018594
TI  - [High-altitude pulmonary edema (author's transl)].

PMID- 1018595
TI  - [Dip-stick screening method to detect the asymptomatic bacteriuria of pregnancy
      (author's transl)].

PMID- 1018597
TI  - [Cerebrospinal fluid cells (author's transl)].

PMID- 1018596
TI  - [The help of coagulation tests in preventing thromboembolism in neurosurgery
      patients (author's transl)].

PMID- 1018598
TI  - [Detection of urinary tract infections (author's transl)].

PMID- 1018599
TI  - [Mountain medicine (author's transl)].

PMID- 1018600
TI  - [Early medical rehabilitation in general hospitals (author's transl)].

PMID- 1018601
TI  - [Present conditions and possibilities of the medical rehabilitation in special
      hospital-institutes in health resorts (author's transl)].

PMID- 1018602
TI  - [Cutaneous and rectosigmoidal cavernous hemangiomas. Bean's syndrome].

PMID- 1018603
TI  - [Radiologic aspects of schwannomas of the 2nd duodenum with extrinsic development
      (apropos of 3 cases)].

PMID- 1018605
TI  - [Internal lateral sphincterotomy].

PMID- 1018604
TI  - [Role of lateral sphincterotomy in the treatment of anal fissures].

PMID- 1018606
TI  - [Insulins and insulin therapy].

PMID- 1018607
TI  - [Anti-collagen autoantibodies in the aged].

PMID- 1018608
TI  - [Comparative ventilatory adaptation during thermal stress at altitude and at sea
      level].

PMID- 1018609
TI  - [Research on automatic perimetry].

PMID- 1018610
TI  - [Urinary excretion of 17-ketosteroids studied by gas chromatography in thyroid
      diseases].

PMID- 1018611
TI  - [Visualization and numerical treatment of images. Applicatory prospects].

PMID- 1018612
TI  - [Value of the comparison of tissue distribution of Rb and K, studied by atomic
      absorption spectrophotometry and by radioisotopes].

PMID- 1018613
TI  - [Use of pyrrolidone magnesium carboxylate in uterine dyskinesia].

PMID- 1018614
TI  - [Clinical experimentation with a new vasodilator: cinepazide maleate in arterial
      diseases of the lower limbs].

PMID- 1018615
TI  - [Pavaverine cromesilate, vascular protector study in arterial hypertension].

PMID- 1018616
TI  - [Clinical study of injectable amiodarone in arrhythmia].

PMID- 1018617
TI  - [Use of a combination of alpha-amylase and tetracycline in a geriatric
      department].

PMID- 1018618
TI  - [Experimentation with Atherulip 500 (apropos of 30 cases)].

PMID- 1018619
TI  - [Clinical trial of a new analgesic, floctafenin in 100 patients].

PMID- 1018620
TI  - [Alkaloids of the Annonaceae: composition of the bark of the trunk and roots of
      Enantia pilosa].
AB  - The alkaloidal content of stem- and root-bark of Enantia pilosa Exell
      (Annonaceae) was studied and compared to that of other Enantia spp. Six aporphine
      alkaloids were isolated; two alkaloids, oliverine and oliveridine, were found in
      major amounts; two oxoaporphines, liriodenine and lanuginosine, were present; two
      other alkaloids, N-oxyoliverine and N-oxyoliveridine, were isolated for the first
      time. Quaternary alkaloids from stem-bark are presently under investigation.

PMID- 1018621
TI  - The alkaloids of Strychnos dolichothyrsa.
AB  - In the stem bark of Strychnos dolichothyrsa Gilg ex Onochie et Hepper
      (Loganiaceae) the following alkaloids were found: bisnor-dihydrotoxiferine,
      bisnor-C-curarine, bisnor-dihydrotoxiferine N-oxide and bisnor-dihydrotoxiferine
      di-N-oxide. Tentatively, two alkaloids were identified as bisnor-C-alkaloid D and
      18-deoxy Wieland-Gumlich aldehyde. Bisnor-dihydrotoxiferine seems to give
      dichlorometho compounds and N-oxides easily, analogous with strychnine and
      brucine.

PMID- 1018622
TI  - Antineoplastic agents. 42. The butterfly, Prioneris thestylis.
AB  - Isoguanine (2) was found to be an antineoplastic constituent of Prioneris
      thestylis Dbldy. wings. Three other purine components of the butterfly wings were
      identified as hypoxanthine (3), uric acid (4) and xanthine (5). Isolation of
      urocanic acid (6) from the same wing material represented the first detection of
      this interesting histidine derivative in an arthropod.

PMID- 1018623
TI  - Thebaine in tissue culture of Papaver bracteatum Lindl, population Arya II.

PMID- 1018624
TI  - [Chromosome aberrations in a culture of human peripheral blood lymphocytes
      irradiated with Cf252 and Co60].

PMID- 1018625
TI  - [Clinical aspects of modeling nonuniform irradiation].

PMID- 1018626
TI  - [Leukocyte reaction to splenectomy as dependent on bone marrow irradiation].

PMID- 1018627
TI  - [Blood serum enzymes in acute radiation sickness].

PMID- 1018628
TI  - [239Pu distribution in bone tissue elements and the effects of DTPA on this
      process].

PMID- 1018629
TI  - [Experimental cytochemical indices of the blood and bone marrow in local tumor
      irradiation].

PMID- 1018630
TI  - [Late complications of the radiotherapy of nontumorous diseases].

PMID- 1018631
TI  - [Hematopoiesis in experimental total irradiation and the therapeutic use of
      cysteine and tetrahydrofolic acid].

PMID- 1018632
TI  - [Epistemiologic analysis of homeopathic medicine].

PMID- 1018633
TI  - [Cestoda of the genus Raillietina Fuhrmann, 1920 (Cestoda-Davaineidae), parasites
      of Columbiforms].

PMID- 1018634
TI  - [Microbiological study of salt (sodium chloride) of marine origin].

PMID- 1018635
TI  - An exploratory multi-level attempt to investigate intrapersonal and interpersonal
      patterns of 20 Athenian families.
AB  - The present study is an attempt to explore patterns of family relationships in
      the context of milieu specific value and role assumptions and to capture the
      trends in relation to social change. Information collected includes intrapsychic
      as well as interpersonal material elicited by a combination of tools administered
      individually and conjointly. The revealed patterns -- extreme emphasis on the
      future achievement of the child as a shared family goal, the mother's central
      role which was shown to inhibit constructive processes, the distant marital
      relationship, and scapegoating of the child because of denied marital
      difficulties -- are shown to create conflict and tension in all members and
      render cooperation and decision-making difficult. It is attempted to interpret
      the above-mentioned patterns in the light of traditional value and role
      assumptions. The analysis seems to indicate that the adherence to the
      dysfunctional patterns appears to serve the function of preserving stability of
      the family in a period of transition.

PMID- 1018636
TI  - The relationship between marital status and mental illness.
AB  - The relationship between marital status and mental illness was investigated in a
      relatively new psychiatric hospital in the Mid-Western State of Nigeria. The
      results showed a different pattern from what has been reported from other
      studies. In this study, it was found that single persons had the largest number
      of referrals, followed closely by married persons. The widowed and divorced had a
      relatively small number of referrals. There were more male than female patients
      and there were also sex and age variations in the type of mental disorders. The
      explanation for this could be related to the social structure of the population,
      and the legal and social definitions of the concepts of marriage and divorce. It
      was not possible, because of lack of relevant population data, to compare the
      hospital rates with those in the population at large. Future work along this line
      and for over a longer period is suggested.

PMID- 1018637
TI  - A quest for purpose in psychic research.
AB  - Metapsychiatry is a term born of necessity to designate the important but
      hitherto unclassified interface between psychiatry and mysticism. By "mysticism"
      the author means phenomena experienced by the senses but not explainable by the
      intellect. Examples of such phenomena are dreams, ESP, faith healing and so
      forth. The author believes that such phenomena were endowed by nature as life
      preserving functions. Thus, precognition is a sort of psychic radar, warning an
      individual of impending danger; dreams are a safety valve for potentially
      psycholytic repressions; and faith is an important element in the healing
      process. Such phenomena are probably a primitive acquisition, latent in all of
      us. They should not be treated merely as divine manifestations requiring no
      further explanations. Scientists must seek rational answers, and physicians
      should seriously consider using gifted, reputable psychics as paramedical aides.

PMID- 1018638
TI  - Anthropological perspectives on population growth.
AB  - Rapid population growth affects many different system levels simultaneously: the
      individual, the family, the community, the nation-state and the world. What may
      appear to be an optimal population level for one system, given certain value
      premises, may not be optimal for another. Anthropologists can contribute to an
      understanding of rapid growth by generating an appreciation for the complexity of
      the phenomenon, and by providing representation for a range of cultural
      viewpoints. This may help to reduce the risk we now run of committing all of
      mankind to a singular path which may prove to be an evolutionary dead end.

PMID- 1018639
TI  - School psychological emergency interventions proposal for guidelines based on
      recent Israeli experience.
AB  - The Yom Kippur War and its stressful aftermath created a number of special
      psychological effects in Israeli schools. During that period mental health and
      counseling services were available and made use of in the educational system.
      Extensive experiences permit an attempt to delineate guidelines for future school
      psychological emergency interventions. These guidelines rest on the supposition
      that the planning and delivery of professional emergency interventions resemble
      those governing routine mental health services in a number of crucial aspects.
      Firstly, the need for an educated anticipation of problems, their kinds, their
      ecology and other characteristics. Schematically, three categories of emergency
      reactions could be expected in schools: shock and grief, and other acute
      disturbances; fear and its psychological concomitants; confusion, perplexity, and
      their attitudinal accompaniments. It is noted that the stressful event can also
      generate positive effects. Secondly, the necessity for a preliminary, on the
      spot, assessment of psychological affliction in any specific emergency case. Such
      examination should be done against the background of the total emergency
      situation (locally and country-wide), as well as the chronic characteristics of
      the particular school or system. Third, the requirement for deliberate planning
      of the intervention program. In this phase, judgements have to be made about the
      recipients of the aid, the methods of help and the levels at which professional
      services will be extended. Fourth, the consideration of important clinical and
      community psychological principles during the execution of the program.

PMID- 1018640
TI  - Short-term intervention: a model of emergency services for times of crisis.
AB  - This paper approaches 'crisis' in system terms. The analysis is applied broadly
      to organization and community systems, as well as to personality and small-group
      systems. Based primarily on current developments in Israel, it is written from
      the viewpoint of a community social worker. Using public health theory, the
      author develops a model of three distinct types of social service systems:
      Restorative (traditional), Curative (crisis-intervention in the literature of
      therapy), and Preventive. He goes on to elaborate both the general
      characteristics of these service systems and the particular emergency-oriented
      contribution each can make in times of community-wide crisis.

PMID- 1018641
TI  - Cultural perspectives on the range of human behavior.
AB  - Traditional societies provide a homogeneous world view for everyone, encouraging
      people to work towards specific objectives. Lack of flexibility in the culturally
      defined ways of reaching these objectives creates considerable distress for
      individuals. In rapidly changing urban settings, unlimited modalities create the
      anxieties which in turn lead people to search for security in unsuitable patterns
      of belief and behavior. Others tolerate uncertainty better if the culture
      assisted them in developing skills for becoming involved in short term immediate
      objectives without having to mortgage the present for a vague future. In our own
      society recent reorientation towards a traditional type fatalism and a de
      emphasis on the Puritan work ethic reflects a marked value shift which may
      stultify many, much as it fosters increased individualization among others.

PMID- 1018642
TI  - Alcoholism as a political problem in Chile.
AB  - Chile has a very serious alcohol problem. 20% of the population over 15 years of
      age are problem drinkers, - 15% are excessive drinkers, and 5% are alcoholics.
      Excessive drinking, particularly inebriety, is considered to be the core of the
      alcohol problem. During Allende's government, there was an increasing concern for
      the national patterns of drinking. Workers began to become conscious that
      drinking seriously limited social and political participation. And patterns of
      alcohol abuse among men predict stimulated conservative attitudes in women. This
      paper discusses the concept of alcoholism as a disease, considering that alcohol
      addiction is a part of a wider problem, alcohol culture, which, in the context of
      the situation in Chile in 1972, had to be seen ideologically as opposed to the
      revolutionary process.

PMID- 1018643
TI  - Space, territory and psychiatry.
AB  - Space and territory have been the hidden dimensions of human and other animal
      life. Beginning with studies reported in animals, and incorporating the few
      formal studies and several informal observations of man, this paper explains the
      importance of mastering the unwritten rules of space and territory which differ
      with individual cultures in relation to the behavioral aberrations possibly
      resulting from the disrupted territoriality of modern urban life.

PMID- 1018644
TI  - A medical model vs. a normative approach: the place of values in community
      psychiatry.
AB  - Based on a series of consultations with the staff in a mental hospital, which
      followed staff-patient meetings, the point of view taken derives from Scheff's
      'social system' model, according to which psychiatric symptoms are considered as
      labelled violations of social norms, and mental illness is considered as a social
      role. It was found that in a somewhat cyclical succession, patient deviance was
      followed by the staff's spontaneous moral indignation. But thanks to the
      intervention of a medical idelogy, this was channelled and transformed into an
      impersonal, value free, non-judgemental reaction. It seems that as a first step
      towards humanizing their relationships with patients, the staff must be prepared
      to engage in a clarification and definition of their moral convictions. A major
      therapeutic goal should be to help de-moralized people, called mental patients,
      to acquire a new sense of morality and self-responsibility.

PMID- 1018645
TI  - Priorities in paediatrics.

PMID- 1018646
TI  - The obstetrician's dilemma.

PMID- 1018647
TI  - Prognosis in early rheumatoid arthritis.

PMID- 1018648
TI  - Perinatal implications of the respiratory distress syndrome.
AB  - Major advances in the prevention and treatment of the respiratory distress
      syndrome (RDS) have occurred. Since 1970 there has been a fall in the mortality
      rate but not in the incidence. Persistence of the disorder could be partly
      accounted for by the increasing practice of elective delivery in normal
      pregnancies. In 1974 and 1975, 28 (25%) of babies with RDS were delivered this
      way and six died. The major problem appeared to be mistaken gestational age.

PMID- 1018649
TI  - Post-infarction cardiac rupture.
AB  - Three allied conditions are described in this paper: (i) haemopericardium with
      cardiac rupture (5 cases); (ii) haemopericardium without rupture (2 cases); (iii)
      pseudoaneurysm (1 case). In the first 2 of these, the significant features were
      clinical deterioration with shock 3 or more days after infarction, recurrent
      cardiac pain, cardiac tamponade, and immediate or later ineffectiveness of
      counterpulsation. An additional feature in the second group was the development
      of haemopericardium after heparin therapy. In the third group, infarction
      followed by left ventricular failure and progressive cardiac enlargement was the
      significant feature. An apical systolic murmur was not present, as a false sac
      had not been formed. Ante-mortem diagnosis depends upon an appreciation of these
      features. Without it successful surgery is impossible. There were 4 survivors in
      this group of 8 patients.

PMID- 1018650
TI  - Diverticular disease of the colon and megacolon. Incidence in a psychiatric
      centre compared with a teaching hospital.
AB  - A five-year survey of hospital admissions at a modern mental hospital reveals a
      rarity in the incidence of diverticular disease of the colon and its
      complications and a greatly increased frequency of idiopathic megacolon and its
      complications compared with patients admitted to a general hospital.

PMID- 1018651
TI  - Smoking in nurses.
AB  - An anonymous questionnaire requesting information on smoking habits was
      administered to 220 randomly chosen trainee and registered nurses (159 females
      and 61 males). There was no significant difference between the proportion of male
      nurses (55-7%) and the proportion of males (45-0%) in the Australian sample who
      smoked. However, the 52-2% of female nurses smoking was significantly greater
      than the 29-0% reported for the Australian female population. There was some
      indication that the increased smoking in female nurses reflected a response to
      stress. Further analysis showed that nursing personnel were giving up smoking at
      the same rate as the general Australian sample.

PMID- 1018652
TI  - A functional assessment of total knee replacement in the arthritic patient.
AB  - The aims of knee replacement are to provide freedom from pain and a return to a
      resonable level of function. A survey was undertaken to determine the functional
      advantages of knee replacement and problems that may still be encountered by the
      patient. The results of the survey highlighted certain advantages and problem
      areas. It also pointed out the seemingly greater functional value of the knee
      replacement in those patients who had no problems in other joints.

PMID- 1018653
TI  - Angiomatous osteolysis of the skull vault.
AB  - A case is reported of angiomatous osteolysis of the calvarium. This condition
      normally affects long bones and there is only one previous report in literature
      of massive osteolysis of the skull. The clinical, radiological and pathological
      implications of this condition are considered.

PMID- 1018654
TI  - Common problems in paediatric anaesthesia.

PMID- 1018656
TI  - Transfusion therapy of thrombocytopania.

PMID- 1018655
TI  - The medical undergraduate programme at McMaster University: learning epidemiology
      and biostatistics in an integrated curriculum.
AB  - The medical undergraduate programme at McMaster University is a three-year
      integrated course in which major emphasis is placed upon self-directed, problem
      based learning. Group tutorials are the major meeting place for students, and
      there are very few formal lectures. In this paper we describe the curriculum in
      broad outline and the way in which epidemiology and biostatistics have been
      incorporated into it in the past seven years.

PMID- 1018657
TI  - Nocturnal enuresis.

PMID- 1018658
TI  - The management of hand injuries.

PMID- 1018659
TI  - Pernicious anaemia, duodenal ulcer and the gastric mucosa.

PMID- 1018660
TI  - Position statement on alcohol.

PMID- 1018661
TI  - White sponges and surgical wound illumination.
AB  - A study has been made of the effect of glare in the surgeon's field of vision
      from reflected light associated with white surgical sponges. Reflected light
      increases by as much as 226% with the use of white sponges. Standardized
      measurements indicate that this glare reduces visual acuity, darkens colour
      interpretation and fatigues the surgeon. A suggested solution is to slightly
      darken the colour of surgical sponges.

PMID- 1018662
TI  - Residual disability after industrial hand injuries. A review of 218 patients.
AB  - The case records of 218 patients with residual hand disability were reviewed.
      Sixty-six per cent had significant stiffness of the digital joints
      (metacarpophalangeal and proximal interphalangeal); 25% had amputation of part or
      whole of the digit; 33% of these had troublesome neuromata; 7% had residual
      numbness; 25% had more than one operation on their injured hand. The average age
      of the patients was 44 years. The average time off work was 10 weeks. The average
      experience in the job before injury was six years.

PMID- 1018663
TI  - Reducing hospital readmission rates among schizophrenics.
AB  - Most schizophrenics become in-patients in State mental hospitals, and most
      improve on neuroleptic medication and are rapidly discharged. The majority
      require long-term medication; the single most important factor in maintaining
      remission. This paper describes a mirror-image study using patients as their own
      controls, and demonstrates the highly significant differences in hospitalization
      before and after the administration of a depot phenothiazine. It highlights the
      need for vigorous and determined out-patient follow-up. It is suggested that the
      costs of an adequately staffed clinic are still small when compared with the
      costs of hospitalization. Subgroups of poor drug-responders, sex differences,
      variations in side effects and frequency of administration of the depot drug
      require further evaluation.

PMID- 1018664
TI  - Urinary sodium, potassium and creatinine excretion in hypertensive and
      normotensive Australians.
AB  - Studies were made in urine obtained from people attending for routine measurement
      of blood pressure in a screening programme. Subjects with diastolic blood
      pressure between 95 and 109 mm Hg excreted significantly more sodium than the
      group with diastolic blood pressure below 90 mm Hg. Urine volumes, potassium
      excretion and creatinine excretion did not differ significantly between the
      groups.

PMID- 1018665
TI  - Antibody to parietal cells in patients with duodenal ulcer, and relationship to
      pernicious anaemia.
AB  - Of 160 patients with pernicious anaemia, none had current duodenal ulceration,
      whereas in a random population of similar age and sex distribution some 5% would
      be expected to have a duodenal ulcer. Parietal-cell antibody was detected in
      serum from 8 of 169 men (4-7%) and from 2 to 31 women (6-4%) with duodenal
      ulceration. None of the 200 duodenal ulcer patients had antibody to intrinsic
      factor. The prevalence of these antibodies in duodenal ulcer patients was not
      significantly different from that in control subjects of similar age and sex
      distribution. The decreased prevalance of duodenal ulcer in pernicious anaemia
      patients implies that pernicious anaemia must be less prevalent in duodenal ulcer
      patients than in a random population; but it appears that this cannot be
      attributed to an absence of gastric autoimmunity in patients with duodenal ulcer.
      To resolve this disrepancy, we suggest that pernicious anaemia is determined not
      only by autoimmune reactions, but also by independent genetic and environmental
      factors which influence the state of the gastric mucosa.

PMID- 1018666
TI  - Human pulmonary dirofilariasis associated with pleural effusion.
AB  - Tuberculosis, untreated pneumonia and other chest infections were excluded as
      possible causes of histological features observed in patient who had been
      discovered in a chest X-ray survey. Pleural effusion was eventually attributed to
      a dirofilarial granuloma found in a small pulmonary artery.

PMID- 1018667
TI  - Enuresis--an approach to the established problem.

PMID- 1018668
TI  - Enuresis.

PMID- 1018669
TI  - The Medical Register of South Australia for 1976.
AB  - An analysis of the Register of Medical Practitioners and specialists of South
      Australia for 1976 shows that South Australia has a more favourable doctor
      population ratio than other parts of Australia, although some specialities and
      rural areas are undersupplied. With the planned increase in the output of
      doctors, the State may soon be saturated and some adjustments may have to be made
      in the numbers of students accepted and/or the distribution of graduates.

PMID- 1018670
TI  - The management of nocturnal enuresis.

PMID- 1018671
TI  - Diagnosis of giardiasis.

PMID- 1018672
TI  - Spironolactone and acute moutain sickness.

PMID- 1018674
TI  - Manslaughter by heat stroke. A note on the trial.

PMID- 1018673
TI  - Manslaughter by heat stroke. Medical comment.

PMID- 1018675
TI  - A case of manslaughter by heat-stroke.
AB  - In the course of his treatment by a herbalist who had undertaken to cure his
      disability, a mildly spastic retarded four-year-old child was immersed in a heap
      of fermenting horse manure for 40 minutes. He was unconscious when removed and
      died two days later despite intensive care in a children's hospital. When medical
      aid was sought a false history was given and the true nature of the child's
      illness, heat stroke, was not determined until after death. The herbalist was
      subsequently convicted of manslaughter.

PMID- 1018676
TI  - The Brisbane floods, January 1974: their impact on health.
AB  - In the 12 months following the Brisbane flood of 1974, 234 flooded families (695
      persons) and 163 non-flooded families (507 persons) were interviewed to ascertain
      changes in health status. We found that the number of visits to general
      practitioners, hospitals and specialists were all significantly increased for
      flooded persons in the year following the flood. Persistent psychological
      symptoms, which included irritability, nervous tension and depressed mood,
      predominated in those seeking medical care, and the consumption of sleeping
      tablets and psychotropic drugs rose. Increased psychological symptoms were
      significantly more common in female than in male flood victims and significantly
      more common in both sexes than increased physical complaints. There was no
      increase in mortality after the flood. The incidence of psychiatric symptoms was
      directly related to dissatisfaction with help received.

PMID- 1018677
TI  - Freshwater drowning and near-drowning accidents involving children: a five-year
      total population study.
AB  - A large total population study of childhood fresh water immersion accidents is
      reported. The study was undertaken in the City of Brisbane over the five-year
      period 1971 to 1975 inclusive, and 111 fresh water immersion accidents involving
      children were studied and analysed. The childhood fresh water immersion accident
      rate, including drowning and near-drownings, of 10-43 per year per 100,000 at
      risk (fatality rate of 5-17) is the highest reported. If an unsupervised child
      gets into difficulties in fresh water and loses consciousness he has a 50% chance
      of dying. The immersion accident rate has doubled over the last six years. Age
      specific immersion accident rates have been calculated, and have revealed that,
      in the toddler group (12 months to 23 months), the fresh water immersion accident
      rate is 50-01 per 100,000 (fatality rate of 22-55). Rates for drowning and near
      drowning accidents after a fresh water immersion, by site, age and outcome
      (survival versus fatality), are also presented for the first time. Swimming pools
      produce 6-20 immersion accidents per year per 100,000 children at risk, and the
      domestic family bath tub produces 1-78. Possible factors explaining the high
      incidence are discussed, and comparisons of drowning rates from other centres are
      made.

PMID- 1018678
TI  - Attitude change: be reasonable, do it my way.
AB  - Governing most of medical practice are our attitudes towards people, policies,
      and procedures. This article considers attitude components and models of attitude
      change. Some consequences are discussed as a conceptual survival kit for hospital
      staff, in the hope that as we become more aware of how we form attitudes, we will
      be less inhibitory to healthy change.

PMID- 1018679
TI  - Principles of the role of general practitioner obstetricians and specialists in
      obstetric care.

PMID- 1018680
TI  - Problems for small group discussion: the "slices of cake" question.

PMID- 1018681
TI  - Cystinuria.

PMID- 1018682
TI  - Oral hypoglycaemic agents--dangers and contraindications.

PMID- 1018683
TI  - Thrombosis--perspective on a major side effect of oral contraceptives.

PMID- 1018684
TI  - Carbon dioxide-dependent Staphylococcus aureus.

PMID- 1018685
TI  - The sensitivity of urinary pathogens seen in a private pathological practice.

PMID- 1018686
TI  - [Accidental contamination with tetrachlorodibenzoparadoxine. Considerations on
      the episode I.C.M.E.S.A].

PMID- 1018687
TI  - [Medical control of workers exposed to benzol].

PMID- 1018688
TI  - [Model for an environmental and biostatistical data register].

PMID- 1018689
TI  - [Significance of serum lead levels in adults living in the Veneto region, not
      occupationally exposed to lead].

PMID- 1018690
TI  - [Professional allergy due to phenylglycine chloride chlorhydrate].

PMID- 1018691
TI  - [Acute and chronic effects of cotton dust inhalation: study on byssinosis].

PMID- 1018692
TI  - [Environmental dust in foundries. Measurements and considerations of the
      silicosis risk].

PMID- 1018693
TI  - [Persistence of karyotype alterations in lymphocytes 10 years after benzene
      poisoning].

PMID- 1018694
TI  - [Chromosomal changes in the cultured peripheral lymphocytes of an x-ray operator
      involved checking bone fracture reductions during surgery].

PMID- 1018695
TI  - [Preclinical changes of myocardial contractility as an early sign of carbon
      disulfide poisoning].

PMID- 1018696
TI  - [Subacute lead poisoning with severe polyneuritis in a ceramic worker].

PMID- 1018697
TI  - [Increase of Feulgen's reaction response in peripheral blood lymphocytes in
      benzene-poisoned subjects 10 years after intoxication. Preliminary data].

PMID- 1018698
TI  - [Dynamic electrocardiography in industrial medicine. Preliminary results of some
      possibilities of use].

PMID- 1018699
TI  - [Disease due to vibrating tools in forestry workers; intensity and
      characteristics of observed vibrations].

PMID- 1018700
TI  - The plasma scalpel.
AB  - The plasma scalpel simultaneously cuts tissue and cauterizes blood vessels
      measuring 3 mm in diameter with a small, hot (3000 C) gas jet. In animal studies,
      the amount of hemorrhage has been shown to be less with the plasma scalpel than
      with steel or electrosurgical scalpels, and incisions have healed without
      complications. Amount of damaged tissue is limited. Human trials are under way,
      and the device shows promise as a clinical tool.

PMID- 1018701
TI  - ECG telephone transmission for monitoring pacemakers and cardiac arrhythmias.
AB  - A network of ECG telephone transmission has been established which uses simple
      and inexpensive equipment, and which is aimed particularly at arrhythmia
      monitoring. Hospitals in areas remote from major medical centers are able to
      transmit to the Toronto General Hospital for expert advice. 400 patients in their
      homes may transmit to any of these hospitals for monitoring of pacemaker function
      or intermittent cardiac arrhythmia. Any patients in the Toronto General Hospital
      not admitted for a cardiac problem may be monitored via telephone by the expert
      nurses in the coronary care unit if a cardiac arrhythmia should arise. Equipment
      for the system has been carefully designed to minimize cost and to make it simple
      to use, particularly for the old or infirm patients in their homes. Transmissions
      between hospitals meet American Heart Association specifications for ECG
      recording. Transmissions of arrhythmias from patients' homes are carried out with
      a reduced low-frequency response. Expert cardiologists find both transmissions
      acceptable for their particular purpose. Standards should be set for simple,
      economic transmission systems as well as for those meeting the most stringent
      criteria.

PMID- 1018702
TI  - Improving the efficiency of a tubular membrane oxygenator.
AB  - The development of a tubular membrane oxygenator is described. Fine silicone
      rubber tubes are inserted into a large silicone rubber tube and sealed. Oxygen is
      blown through the fine tubes, blood flows through the large tube, and the gases
      are exchanged through the wall of the fine tubes. The efficiency of the device is
      improved by increasing the gas pressure, which is followed by bubble formation in
      the blood, and which is therefore unacceptable. By arranging the inside tubes in
      a wavy pattern and by repeatedly stretching them the efficiency is increased
      without side effects.

PMID- 1018703
TI  - [Antibacterial activity of urea combined with terizidone on pathogenic strains
      isolated from urine cultures].

PMID- 1018704
TI  - [Importance of the paraproteins present in prostatic carcinoma].

PMID- 1018705
TI  - [Anatomo-radiological studies in the pathology of the pyelo-ureteral junction].

PMID- 1018706
TI  - [Social importance of calculosis of the uropoietic system].

PMID- 1018707
TI  - [Early diagnosis of bladder cancer].

PMID- 1018708
TI  - [Treatment of carcinoma of the prostate].

PMID- 1018709
TI  - [Dissolution of urate renal calculi by means of urine alkalinization.
      Presentation of 6 cases].

PMID- 1018710
TI  - [Sponge kidney. Clinical considerations on 3 cases].

PMID- 1018711
TI  - [Chronic ureteritis, eosinophilic pyelonephritis and xanthogranulomatous
      reactions in 2 cases of hydatid cysts of the kidney].

PMID- 1018712
TI  - [Carcinoma of the prostate originating in the periurethral glands].

PMID- 1018713
TI  - [Ureteral damage caused by a coxo-femoral prosthesis].

PMID- 1018714
TI  - [Trittico and endoscopic urological procedures].

PMID- 1018715
TI  - The relation between audition and vision in the human newborn.
AB  - Four studies were conducted to investigate the relation between audition and
      vision in the human newborn. In all four studies visual activity was recorded
      with infrared corneal-reflection technqiues in 1- to 4-day-old infants. Study 1
      concerned the effects of sound at midline on scanning in darkness and in a lit
      but formless field. In the dark compared to light, newborns maintained better eye
      control, centralized fixations, scanned with smaller eye movements, scanned less
      dispersely, and were wider-eyed. In a blank field, sound caused newborns to
      maintain better eye control, centralize fixations, scan with small eye movements,
      constrain fixations, and be wider-eyed than in silence. Sound had little effect
      on scanning in the dark beyond constraining fixations. Study 2 concerned the
      effects of sound at midline on scanning vertical and horizontal edges. Visual
      activity was different for the two visual stimuli. While viewing a vertical
      rather than a horizontal edge, newborns maintained better eye control and fixated
      closer to the position of the vertical edge. Newborns crossed the position of the
      horizontal edge when that edge was present. Sound affected scanning in general,
      centralizing fixations for newborns not already looking centrally, but sound did
      not affect the frequency of edge crossing. Study 3 concerned the effects of
      laterally presented sound on scanning spatially consonant or dissonant vertical
      bars. The major finding was that infants were sensitive to the spatial property
      of sound. Infants shifted fixations first toward and then gradually away from
      sound. Study 4 was an attempt to determine whether there is an effort constraint
      on the simultaneous functioning of auditory and visual systems. The effects of
      two differentially salient sounds on scanning two differentially salient visual
      stimuli were examined. Although the results appeared to support the idea of an
      effort constraint, the data were accounted for parsimoniously in terms of the
      spatial influence of sound of scanning. The data on visual activity were
      discussed in terms of the presence of inherent information-acquisition routines
      in the newborn. It was concluded that sound influences visual epistemic behavior
      even at birth.

PMID- 1018716
TI  - Acid-soluble purine and pyrimidine derivatives in cow's milk produced on normal
      feed and almost protein-free-feed with urea as the main nitrogen source.
AB  - In two groups of Ayrshire cows (group I normal feeding with protein, group II got
      mostly urea as N-source), the TCA-soluble purine and pyrimidine derivatives of
      the milk were determined quantitatively. The O.D. [U/I] at pH 7-5 and 260 nm was
      higher in group II than in group I. The difference in N-nutrition of the animals
      has no influence on the composition of the purine and pyrimidine fractions
      investigated, especially with regard to orotic acid, uric acid, and CMP. At early
      stages of lactation the contents of CMP and uric acid were relatively high, but
      decreased with longer time of lactation. In opposition to this the orotic acid
      content increased in the same period. These tendencies could be registered in
      both groups. Besides CMP, uric acid, and orotic acid the minor nucleotides, NAD,
      AMP, GMP, UMP and others have been determined quantitatively. Their maximum has
      been found at the beginning of the lactation period and, in general, their
      contents were higher in group II than in group I.

PMID- 1018717
TI  - [Residue retention of ethephon on stone fruits and berries. 2. Ethephon residues
      in currants and gooseberries].
AB  - Studies on the residual behaviour of Ethephon on black and red currants showed
      that the fruits contained on an average 0.39, 0.81, 2.2 and 0.64, 1.14, 1.04
      p.p.m. of Ethephon, respectively, after application of 0.04, 0.06 and 0.08%.
      Flordimex mixture. When a concentration of 0.08% was applied to gooseberries, the
      fruits contained on an average 0.31 p.p.m. of Ethephon. The juice of black
      currants contained relatively larger residues.

PMID- 1018718
TI  - Pharmacologic aspects of pentamidine.
AB  - Pentamidine is an aromatic diamidino compound synthesized originally for the
      therapy of trypanosomiasis. The pharmacologic effects of pentamidine vary,
      depending on its route of administration. In animals, the dominant effects have
      been a precipitous, transitory drop in blood pressure after injection and renal
      toxicity following repeated administration. To avoid the possibility of immediate
      toxic reactions associated with iv administration, we now usually give the drug
      im to humans. Further interest in pentamidine has been stimulated by its
      usefulness in the treatment of interstitial pneumonia caused by Pneumocystis
      carinii. In some patients receiving antineoplastic or immunosuppressive therapy
      who have superimposed P. carinii pneumonia, pentamidine may cause serious renal
      toxicity. Distribution and excretion studies in animals indicate pentamidine is
      deposited in tissues, with the greatest concentration in the kidneys, and
      gradually eliminated over a prolonged period. The mechanism of action of
      pentamidine against P. carinii or the means whereby fixation in tissues and
      subsequent toxicity occur have not been elucidated. Recent investigations to help
      clarify these points indicate that pentamidine inhibits dihydrofolate reductase
      in all tissues studied both in vitro and in vivo. In addition, pentamidine
      interacts and forms water-insoluble products with specific nucleotides and
      nucleic acids.

PMID- 1018719
TI  - [Value of rhizotomy in the treatment of pelvic pain syndromes].
AB  - In 18 Patients with symptomatic coccygodynia due to malignant diseases 7 sacral
      rhizotomies and 11 intrathecal injections of Phenol had been effected. The high
      percentage of good results and the low rate of complications indicates in the
      opinion of the author that these methods are worth a trial in such cases, where
      otherwise only bilateral cordotomy with a much higher incidence of complications
      may be able to obtain pain relief.

PMID- 1018720
TI  - [Percutaneous thermocoagulation of the spinal nerves for analgesia].
AB  - The authors present percutaneous technic treatment of some pain syndrom by
      thermocoagulation of rachidian nerves with radiofrequency generator. This method
      had been employed on 60 patients in various indications (cervico-occipital
      neuralgias, low back pain, stage syndrom, painful scar etc...). After anatomic
      justification one literature analysis precede personal results of this
      therapeutic method. This one is easy to realise and seems to deserve a good place
      in the actual possibility of functional neurosurgery.

PMID- 1018721
TI  - [Extra-intracranial anastomosis: radio-clinical correlations].
AB  - 25 patients have been operated on by means of extra-intracranial anastomosis (22
      with STA-MCA anastomosis, 3 with occipital-MCA anastomosis). 23 patients
      underwent an angiographic study early after surgery (two weeks). The patency rate
      is 14 out of 23 (13 STA, 1 occipital anastomosis). In comparison of its pre
      operative size, the afferent artery has enlarged in the most cases, particularly
      in patients with complete obliteration, either of the carotid artery, or of the
      middle cerebral artery. In every case, only a limited part of the MCA territory
      is visualized through the anastomosis. In no case was the complete MCA field
      visualized; the frontal branches, particularly, are not supplied through a
      temporal anastomosis. In the case of occipital anastomosis, both upper and lower
      branches of MCA are supplied through the new channel. 11 patients underwent a
      second angiographic study, from one year through 28 months after the first one.
      In three patients with no patency on the first angiography the anastomosis
      remained non patent. So, in this series, no anastomosis was seen to became patent
      secondarily. In 8 patients with patency on the first control, the anastomosis
      remained patent on the second angiography. In patients with a pre-operative
      stenosis, no increasing of the size of the vessel could be noticed. The filling
      of the MCA branches is difficult to be discussed, for in these cases, the
      angiographies were not performed selectively through the external carotid artery.
      In patients with a pre-operative thrombosis, an enlarging of the vessels was
      seen, as well as an extension of the intra-cranial filling through the
      anastomosis. Clinical correlations are the following ones: the most patients with
      TIA's had a stenosis. They presented no increasing of the size of the vessels.
      They were doing well after operation, as if a little more of blood supply was
      sufficient to improve the general blood perfusion. Every patient with stroke had
      a pre-operative thrombosis and presented an enlarging of the vessels with a
      better filling on the second angiography, as if a great deal of additional blood
      supply was required; the clinical improvement is slow (3 out of 5) and remains
      often incomplete.

PMID- 1018722
TI  - [Carotid-cavernous fistulas by tearing or rupture of the meningo-hypophysial
      trunk or of one of its branches. Anatomo-radiologic study of 4 cases. Pathogenic
      hypotheses].
AB  - Thr authors report observations relative to four cases of traumatic carotid
      cavernous fistulas for which angiographic pictures were similar. Autopsy
      examination permitted in two cases to establish that the tentorial branch of the
      meningo-hypophyseal trunk was involved in the genesis of both fistulas. One case
      was from a rupture, the other from tearing of that branch. Further examination of
      these two cases showed an absence of sphenoid bone fracture which suggested that
      any arterial perforation or shearing process could be excluded. Thus the
      pathogenic hypothesis of PARKINSON is further sustained. The authors suggest that
      the observed arterial lesions may be due to tensions occuring at the proximal
      part of branches of the meningo-hypophyseal trunk. Such tensions may be carried
      out through tractions on the posterior meningeal walls of the cavernous sinus
      when trauma occur on the posterior temporal area and the petrous bone. Such
      traction forces were shown to be real in one case where a fracture of the dorsum
      sellae and a bilateral caroti-cavernous fistula were caused by a bilateral
      temporo-petrous trauma.

PMID- 1018723
TI  - [Giant aneurysm of the basilar trunk presenting as essential facial neuralgia].
AB  - One case of trigeminal neuralgia and operative giant basilar aneurism is
      reported. This feature is quite rare, this case however emphasizes the importance
      of further investigations before surgery, especially if a direct approach is
      considered.

PMID- 1018724
TI  - [Complementary procedures to the Sjoqvist operation in cancerous cervico-facial
      pain].
AB  - The trigeminal spinal tractotomy of Sjoqvist can be enlarged and give a very good
      result on cancer pain of face and throat. When pain is also cervical, it is
      usefull to associate with the Sjoqvist operation two important procedures: 1
      degree--Instead of a simple posterior cervical radicotomy it seems best to
      practise a selective posterior radicellotomy. This technic has the advantage to
      preserve the sensory proprioceptive capacity of the superior limb, while being
      perform even until C6 and C7 roots. Also in case of recurrence of cervico
      brachial pain, it remains easy to apply a posterior spinal stimulation. 2--The
      spinal nerve has not only a motor function but also a sensory one. The sensory
      fibers travelling through small anastomosis between "LARUELLE Ganglion" and
      cervical roots must be separated to obtain a more complete analgesia.

PMID- 1018725
TI  - [Therapy in the Parkinsonian syndrome].

PMID- 1018726
TI  - [Sodium dantrolene (dantrium) in the treatment of neurogenic muscular spasm].
AB  - Forty patients, whose ages varied from 4 to 65 years, presenting skeletal muscle
      spascitiy as sequel of cerebral palsy, spinovertebral trauma and cerebral
      vascular diseases were treated with Dantrium (dantrolene sodium), a drug muscle
      relaxing. Laboratory data included: electromiography, chronaximetry, EEG and
      blood and urine tests. Clinical followup revealed subjective improvement in the
      patients and also objective decrease of spasticity in a satisfactory number.
      Patients who had improvement with this therapy also had no beneficial results
      with other drugs.

PMID- 1018727
TI  - [5 years of experience in the treatment of parkinsonism with L-dopa and its
      combination with Ro4-4602].
AB  - Eighty-one Parkinsonic patients were treated with L-dopa alone and/or combined
      with Ro4-4602, during 27 to 60 months. The results are reported. 7.2% of the
      patients, who are still being treated, showed good, very good or excellent
      results. There was a relation between the duration of the illness and the degree
      of improvement, the most prolonged Parkinsonisms showed the least improvement.
      The 4:1 proportion of L-dopa and Ro4-4602 was more effective than the 3:2. Adding
      small amounts of L-dopa to the combinations improvement and secondary effects
      increased. No advantages were found using high combined dosages. The main
      secondary effects at the end of treatment were abnormal movements (45% of cases)
      and distonic attitudes (53%). Patients who stoped the medication showed less
      sustained improvement and a high degree of Parkinsonism. This reveals that
      Parkinson's disease continues to envolve in spite of the medication. The "long
      term syndrome" includes the late decrease of effectiveness of the drugs and/or
      the increase of secondary effects.

PMID- 1018728
TI  - Postural hypotension in idiopathic Parkinson's disease. Etiopathology.
AB  - Postural changes in blood pressure were recorded in all 391 patients suffering
      from Parkinson's syndrome over a period of six years. Intraarterial blood
      pressure studies were carried out in those with significant postural hypotension.
      Histological examination of the entire central nervous system and the sympathetic
      ganglia was performed in six patients suffering from idiopathic Parksinson's
      disease. Five of the six patients had Lewy bodies in the sympathetic ganglia.
      Loss of nerve cells was noted in the sympathetic ganglia in those patients that
      demonstrated postural hypotension. The severity of the lesions in the ganglia
      correlated with the severity of postural hypotension in idiopathic Parkinson's
      disease, One case of Shy-Drager syndrome was similarly studied to demonstrate the
      differences in spinal cord and sympathetic ganglia lesions in the two conditions.

PMID- 1018729
TI  - [Treatment of Parkinson's disease with levodopa and a dopa decarboxylase
      inhibitor].
AB  - The combination of L-dopa with carbidopa was administered to 18 patients with
      ediopathic Parkinson's disease and the dose needed to control the manifestations,
      either partially or completely, with the least number of side effects, was
      established.

PMID- 1018730
TI  - Dynamic studies of growth hormone and prolactin secretion in the female rat.
AB  - Blood samples were removed via chronic intra-atrial cannulae every 15 min in
      female rats during the estrous cycle, the last week of pregnancy, parturition and
      suckling. Growth hormone (GH) secretion during the estrous cycle is characterized
      by episodic release, occurring approximately once hourly. The surges in GH
      increase during the last 3-4 days of gestation, and rise to high levels during
      delivery and with suckling. Prolactin (PRL) shows minimal fluctuations during the
      estrous cycle, except for a prominent pulsatile surge during proestrus. PRL rises
      4-6 h prior to parturition and declines during delivery. These studies provide a
      basis for further studies on the dynamics of GH and PRL secretion in the female
      rat.

PMID- 1018731
TI  - Changes in the nuclear volume of rat hypothalamic neurons in old age.
AB  - Nuclear volumes (NV) of neurons in the preoptic are (POA), suprachiasmatic
      nucleus (SC), paraventricular nucleus (PVN), supraoptic nucleus (SO), anterior
      hypothalamic area (AHA), arcuate nucleus (ARN), ventromedial nucleus (VMN),
      dorsomedial nucleus (DMN) and lateral mammillary nucleus (ML) were measured in
      3.5- to 5-month-old female and male rats and in old female and male rats over 22
      months of age. Young adult female rats had larger NV than males in the neurons of
      all measured areas except for the SC during estrus and the ARN. NV of the
      hypothalamic neurons of female rats decreased in old age in all measured areas
      except for the VMN of rats exhibiting prolonged vaginal cornification (PVC). Old
      male rats showed decreased NV only in the neurons of the SC, SO and ML. The
      extent of NV decrease of the hypothalamic neurons was not similar in different
      areas. The sexual difference in neuronal NV in most of the areas disappeared in
      old age. Only the POA of rats with PVC and the ML of old female rats had larger
      NV than those of old male rats.

PMID- 1018732
TI  - Effect of sulpiride on plasma prolactin in rats.
AB  - I.v. injection of sulpiride (S; 0.5-20 mug/100 g b.w.) caused a significant and
      dose-related increase in plasma prolactin (Prl) levels in urethane-anesthetized
      rats, with peak values occuring 10 min after the injection. L-dopa administration
      (2 mg/100 g b.w., i.v.) significantly blunted plasma Prl response to S(1 mug/100
      g b.w., i.v.). S injection (1 mug/rat) into a lateral ventricle also raised
      plasma Prl significantly. Hypothalamic destruction resulted in a prominent
      increase of basal plasma Prl, which increased further following the injection of
      S. These results suggest that S stimulates Prl secretion by its possible direct
      action on the anterior pituitary.

PMID- 1018733
TI  - Vasopressin and oxytocin content of microdissected hypothalamic areas in rats
      with hereditary diabetes insipidus.
AB  - Vasopressin was virtually absent from 5 microdissected hypothalamic areas and
      from the posterior pituitary glands of homozygous Brattleboro rats. The oxytocin
      concentration was normal in all these areas except for the arcuate nucleus, where
      it was absent. These results support the concept that Brattleboro rats have a
      specific defect in biosynthesis of vasopressin. The significance of the absence
      of oxytocin from the arcuate nucleus in these rats remains to be determined.

PMID- 1018734
TI  - Hypothalamic region and pathways responsible for adrenocortical response to
      surgical stress in rats.
AB  - Surgical stress produced no increase in the plasma corticosterone level in rats
      with complete deafferentation of the medial basal hypothalamus (MBH). 30 min
      after surgical stress, the adrenocortical response depended on the integrity of a
      well-circumscribed region of the hypothalamus: the lateral-basal region of the
      retroachiasmatic area (RCAL) that lies not more than 0.5 mm caudally from the
      optic chiasma and is about 0.2 mm high. One week after transsection of this
      region, surgical stress produced no elevation of plasma corticosterone; the
      effect of the operation was independent of whether various combinations of other
      regions and pathways to the MBH were left intact. In contrast, high plasma
      corticosterone levels were found after surgical stress with all kinds of
      hypothalamic deafferentation when the basal region of the RCAL was not
      transected. The possible origin of neuronal fibres running through the RCAL is
      discussed.

PMID- 1018735
TI  - [Electron microscope study of tomato spotted wilt virus on tabacco (author's
      transl)].

PMID- 1018736
TI  - Model of exchange barrier and respiratory surface area in the lung of the
      tortoise (Testudo graeca) and its practical application.

PMID- 1018737
TI  - Histochemical localization of alkaline phosphatase, acid phosphatase, and
      succinic dehydrogenase activities in the epidermis of the freshwater teleost,
      Amphipnous cuchia (Hamilton) (Symbranchiformes, Pisces).

PMID- 1018738
TI  - [Rhythmic contractions of chloroplast of Micrasterias denticulata Breb., revealed
      by time-lapse studies (author's transl)].

PMID- 1018739
TI  - [An improvement of objective photometry of micrographs equipped with a
      photometric density scale (author's transl)].

PMID- 1018740
TI  - [Some possibilities for the preparation of histological micrographs to facilitate
      the quantitative determination of silver as estimated by the degree of blackening
      (author's transl)].

PMID- 1018741
TI  - [Aortic coarctation in the 1st year of life. II. Surgical technics and results in
      77 operated cases].

PMID- 1018742
TI  - [Variations of the technic of use of the saphenous vein in surgical treatment of
      chronic femoro-popliteal arterial obstructions].

PMID- 1018743
TI  - [Evaluation of plasma renin activity and urinary excretion of aldosterone in
      patients with essential hypertension treated with D-L propranolol].

PMID- 1018744
TI  - [Complications of retrograde arterial catheterization using the percutaneous
      femoral route. Observations on 4,686 cases].

PMID- 1018745
TI  - [Clinical study of a new anti-angina drug (Cloridarol) alone and in association
      with beta-blocking agents].

PMID- 1018746
TI  - [Changes in ventricular activation caused by hyperpotassemia. Description of a
      clinical case].

PMID- 1018747
TI  - [Combination of diazepam, pentazocine, propanidid in anesthesia for angiography].

PMID- 1018748
TI  - [Use of intramuscular ketamine for anesthesia in adenotonsillectomy (our clinical
      experiences)].

PMID- 1018749
TI  - [Preventive use of AMCHA in tonsillectomies under general anesthesia. Clinical
      evaluation].

PMID- 1018750
TI  - [Effects of Ketalar on the ocular tonus].

PMID- 1018751
TI  - [Effects of administration of ethrane on the pulmonary structure. I. Studies on
      optic microscopy].

PMID- 1018752
TI  - [Stellate ganglion block in cerebral angiography].

PMID- 1018753
TI  - [Our experience in 1,707 cases of regional anesthesia (1,671 of them peridural
      and 36 subarachnoid)].

PMID- 1018754
TI  - [Syndrome of post-traumatic fat embolism. Clinical study and presentation of 7
      cases].

PMID- 1018755
TI  - [Our experience in 404 cases of acute exogenous poisoning].

PMID- 1018756
TI  - [Establishment, development and prospects of an anesthesia and resuscitation
      department].

PMID- 1018757
TI  - [Dibucaine number].

PMID- 1018758
TI  - [General anesthesia with ketamine chlorhydrate in otorhinolaryngologic surgery.
      Clinical contribution].

PMID- 1018759
TI  - [Combination of propanidid-ketamine in obstetrics and gynecology].

PMID- 1018760
TI  - [Effects of administration of Ethrane on the pulmonary structure. II. Electron
      microscopic study].

PMID- 1018761
TI  - [Effect of vincamine on the re-establishment of wakefulness after fluothane
      narcosis].

PMID- 1018762
TI  - [New type of cardiac stimulator. Rechargeable cardiac pacemaker system].

PMID- 1018763
TI  - [Fat embolism: a new possibility of early diagnosis?].

PMID- 1018764
TI  - [Problems of analgesic treatment in operated carcinoma of the rectum].

PMID- 1018765
TI  - [Postoperative acute renal failure studied from the anesthesiological viewpoint.
      III. Clinical research (46 cases)].

PMID- 1018766
TI  - [Experience with dissociative anesthesia with ketamine in tonsillectomy,
      adenotonsillectomy and ORL minor surgery].

PMID- 1018767
TI  - [The problem of physico-chemical and pharmacological incompatibility of the
      products used in phleboclysis in resuscitation].

PMID- 1018768
TI  - [Clinical experience in the use of pentazocine by rectal administration in
      orthopedics and traumatology].

PMID- 1018769
TI  - [Resuscitation in acute meningoencephalitis in childhood. Clinico-statistical
      study].

PMID- 1018770
TI  - [Gram-negative infections in patients treated with mechanical ventilation and
      antibiotic therapy].

PMID- 1018772
TI  - [Administrative criteria for a coronary care unit proposed by an anesthesiologist
      resuscitator].

PMID- 1018771
TI  - [Resuscitation in a coronary care unit].

PMID- 1018773
TI  - [Results obtained with respiratory resuscitation in 605 patients with heart
      diseases].

PMID- 1018774
TI  - [Problem in the control of left ventricular function during resuscitation. Review
      of literature and comparative study of young and healthy subjects and patients
      with left ventricular insufficiency].

PMID- 1018775
TI  - [Results obtained in the treatment of 585 cases of unexpected cardiocirculatory
      arrest].

PMID- 1018776
TI  - [Anesthesiological and resuscitatory treatment of precocious complications of
      myocardial infarct with indication for injury].

PMID- 1018777
TI  - [Percutaneous left ventricular catheterization at the bedside of patients under
      intensive care].

PMID- 1018778
TI  - [Endocavitary transitory stimulation in acute myocardial infarct].

PMID- 1018779
TI  - [Use of artificial respiration in complicated acute myocardial infarct. Critical
      evaluation].

PMID- 1018780
TI  - [Clinical use of ethrane in gynecology and obstetrics].

PMID- 1018781
TI  - [Mechanisms of control of acid-base equilibrium in the blood and mechanisms of
      control of CO2].

PMID- 1018782
TI  - [Critical evaluation of some methods of prevention of hemodynamic changes caused
      by peridural anesthesia].

PMID- 1018783
TI  - [Aspects of clinical physiopathology and therapy of hypovolemic shock].

PMID- 1018784
TI  - [Surgical units in modern hospital construction].

PMID- 1018785
TI  - [Notes on the embryology and anatomy of the diaphragm].
AB  - The main steps in the embryogenesis of the diaphragm are summarised, with
      particular reference to details of major importance in the formation of
      congenital hernias. Morphogenetic abnormalities of the diaphragm are described.
      Malformations occurring during the different stages of embryonal development
      (agenesia, total or partial aplasia or eventratio, restructuring defects) and
      their incidence are also illustrated. A personal view concerning the topography
      of congenital hernias of the diaphragm is expressed, with particular reference to
      those proceeding through incostant foramina.

PMID- 1018786
TI  - [Acute complications of hernias caused by congenital defects of the diaphragm].
AB  - Following a classification of the various types of congenital hernia of the
      diaphragm, the acute complications that may be caused by such defects of
      diaphragmatic morphogenesis are reviewed. Relative physiopathology is considered,
      particularly as regards the thoracic dimension of large hernias of the cupola. As
      regards visceral hernia, the most typical pictures of the two commonest
      complications, volvulus and strangulation, are described among other aspects. The
      clinical situation is outlined bearing in mind the diversity of anatomoclinical
      pictures in relation to the age of the patient, the type of hernia involved, and
      the period in which the observation was made. The surgical problems involved in
      acute complications concern the approach--although agreement is almost unanimous
      depending on the type of hernia--viscous reduction modalities and the type of
      plastic surgery which is required on each occasion. Postoperative complications
      and the prognosis for these hernias are reviewed briefly.

PMID- 1018787
TI  - [Surgical treatment of postoperative peptic ulcer].
AB  - The literature on postoperative peptic ulcer is reviewed and cases observed in
      the Department of Surgical Anatomy and Operations Course of Turin University in
      the period 1-I-1968 - 31-III-1975 are presented. 183 operations for primary
      gastro-duodenal ulcer were carried out. A variety of techniques was employed,
      including 138 gastric resections using a modified Billroth II technique, with a
      recurrence of 1.3% encountered only in patients in the specified group. 15
      reoperations for postoperative peptic ulcer were performed with the following
      result: very good in 7 cases, good in 6, and 2 postoperative deaths. The two
      deaths concerned a simple gastric reconversion and a gastric re-resection with
      gastro-jejuno-anastomosis. The personal series confirms the statistics presented
      by numerous foreign workers.

PMID- 1018788
TI  - [Role of the duodenum in the digestive function. I. Notes on its physiology].
AB  - A full account is given of recent advances in knowledge of the physiology of the
      duodenum. Modern means of diagnosis have shown that this organ, far from having a
      secondary role in digestive performance, carries out fundamental activities.
      These are described and it is made clear that the duodenum, on its own account,
      is the organ of choice for the digestion and absorption of some important
      nutritive substances. In addition, its motor and, above all, endocrine activity
      serves to direct the functions of the stomach, the intestine, and the glands
      attached to the gastroenteric tract (pancreas and bile ducts).

PMID- 1018789
TI  - [Possibilities and limitations of cryohemorrhoidectomy].
AB  - The cryonecrosis process of haemorrhoids and cryonecrosis of living organic
      tissues follow the same laws. On the basis of these observations and of personal
      experience, the cryohaemorrhoidectomy technique is described and its most
      important practical aspects underlined.

PMID- 1018790
TI  - [Early operation in acute hemorrhagic necrotizing pancreatitis].
AB  - Between 1973 and 1975, the "early" operation was carried out in 15 patients
      suffering from acute haemorrhagic-necrotizing pancreatitis to eliminate necrotic
      parts. Partially necrotizing pancreatitis was identified in 10 patients: 7
      survived. All patients with total pancreatic necrosis died. Surgery consisted of
      digital removal of the necrosis (digitoclasia) and in left resection with
      adequate drainage. Patients with partially necrotizing acute pancreatitis can be
      saved by "early" surgery while in patients with total necrosis surgery must be
      undertaken even earlier, namely before fatal complications set in.

PMID- 1018791
TI  - [Anatomo-topographical notes on a variant of the extraperitoneal approach to tkhe
      lumbar sympathetic chain].

PMID- 1018792
TI  - [The role of the duodenum in digestive function. II. Notes on physiopathology].
AB  - On the basis of the concepts presented in Note I, the effects of excluding the
      duodenum from the digestive circuit are examined. In practice, the effects are
      reflected in disturbances to intestinal canalization with consequent post
      prandial syndromes, and to the digestion and absorption of foods (deficiency
      syndromes). Over and above histological, biological and biochemical findings, the
      severe pathology affecting the entire digestive function brought on by the
      elimination of the manifold, complex activities of the "duodenal laboratory" were
      confirmed clinically.

PMID- 1018793
TI  - [Liposarcoma of the mesentery. Considerations on its development].
AB  - A case of liposarcoma of the mesentery is presented. The succession of
      morphological pictures observed during its protracted (15 years') course are
      described. Attention is drawn to the need to revise diagnositc criteria and make
      them more consonant with the need for a more careful assessment of the prognosis
      in such cases.

PMID- 1018794
TI  - [Unusual localization of an abdominal dermoid cyst].
AB  - A case of epidermoid cyst with rather unusual localization is reported. The cyst
      ran from the rear cavity of the omentum, penetrating between the leaves of the
      mesentery rott as far as the angle formed by the caecum and the final ansa before
      returning along the last ansa for about 20 cm, and compressing it to the point of
      creating an acute occlusive syndrome. Photographs and radiographs of the case are
      presented.

PMID- 1018795
TI  - [Crohn's disease. Introduction].

PMID- 1018796
TI  - [Pathological aspects of Crohn's disease and notes on its pathogenesis].

PMID- 1018797
TI  - [Clinical picture and therapy of Crohn's disease].

PMID- 1018798
TI  - [Surgical treatment of Crohn's disease].

PMID- 1018799
TI  - [Our experience with the treatment of cavitary and external biliary fistulas
      following surgical operations for hepatic echinococcosis].
AB  - Successful treatment of five personal cases of external cavitary and biliary
      fistulae following radical liver hydatid surgery is reported. Stress is laid on
      the fact that complications may still occur, even when the latest techniques are
      employed. These can be avoided if the pathological anatomy and biliary
      physiopathology associated with the disease are fully understood, so that
      techniques can be adjusted to the different situations revealed by pre- and
      intraoperative exploration. Medical or surgical management must be preceded by
      precise knowledge of the reasons for persistence of the fistula.

PMID- 1018800
TI  - [Ultrastructural aspects of the colon epithelium in patients with ulcerative and
      granulomatous colitis].

PMID- 1018801
TI  - [Role of bile salts in tolbutamide metabolism].

PMID- 1018802
TI  - [Known factors in the pathogenesis of ascites in liver cirrhosis].

PMID- 1018803
TI  - [Crohn's disease of the duodenum].

PMID- 1018804
TI  - [Peutz-Jeghers syndrome].

PMID- 1018805
TI  - [Colonoscopy as an indispensable aid in diagnosis of cancer of large intestine.
      Retrospective study].

PMID- 1018806
TI  - [Supramammary hematoma due to rupture of the varices of the superficial
      collateral circulation in a patient with cirrhosis].

PMID- 1018807
TI  - [Problems of arteriosclerosis epidemiology. Analysis of risk factors with a view
      to a possible therapy].

PMID- 1018808
TI  - [Oxygen therapy in pneumology].
AB  - Circumstances under which the use of oxygen-therapy in lung disease can be
      effective and harmless, depend upon a careful evaluation of its indications: they
      are suggested by the clinical need of correction of hypoxaemia as well as by the
      awareness of factors determining respiratory failure and of problems concerning
      O(2) transport and supply to tissues in health and disease. Blood gases
      monitoring enables to control the effects of treatment on arterial O2 and CO2
      tensions thus giving all the useful data for oxygen administering particularly as
      far as components of hyperoxygenated mixtures, flow rate, duration, use of very
      effective low-risk devices (Venturi masks) are concerned. Correction of
      hypoxaemia involves the reduction of hypertension of the pulmonary circulation
      and hyperglobulia, improvement of tolerance of exertion, and attention to the
      metabolic compensation of respiratory acidosis. These results are influenced by
      the nature of the pathogenetic factors behind broncho-obstructive disease, which
      may lead to either a primarily "bronchitis" or a primarily "emphysematous"
      syndrome. An interesting feature relates to prognosis in the case of patients
      making home use of hyperoxygenated mixtures as part of a rehabilitation program,
      or to improve their quality of life. The cost and benifits of such treatment
      should be carefully weighed. Lastly, in the event of protracted treatment,
      attention must be paid to the possibility of toxicity and the means to be adopted
      for its prevention.

PMID- 1018809
TI  - [Gas exchange and acid-base equilibrium in chronic bronchitis and in emphysema].
AB  - Blood gas data for HbO2% and PaCO2 and determination of acid-base balance enable
      the biochemical features of bronchial obstruction to be related to primarily
      "intrinsic" or "extrinsic" factors. Long-term gas studies and ventilation
      mechanics data (lung elastic recoil pressure, maximum expiratory flow at
      different volumes and the corresponding recoil pressures) are also of assistance
      in this respect. Each type of bronchial obstruction thus has its own
      peculiarities, and these are also reflected in the level of metabolic
      compensation for respiratory acidosis.

PMID- 1018810
TI  - [Immunotherapy with BCG in pulmonary tumors].
AB  - Results obtained with immunotherapy in 318 cases of lung cancer showed that an
      initial Tine test is useful prognostically (initial negativity is equivalent to
      poor survival), and survival increases and decreases in function of positivity
      and negativity respectively. The soundness of immunotherapy is borne out by the
      survival data.

PMID- 1018811
TI  - [Illustration and results of antineoplastic chronopharmacology in pulmonary
      tumors].
AB  - Reference is made to a series of cases of lung tumour treated with antiblastic
      drugs over long periods. This method gives the best results in terms of survival
      and tolerance. Encouraging results were also obtained with coadjuvant
      chronobiological corticoid management.

PMID- 1018812
TI  - [Study of various aspects of hepatic function and histomprphology in obesity].
AB  - Data regarding the commonest biohumoral tests of liver function obtained in 53
      highly obese women of more or less young age, non-diabetic, non alcolist and
      without cardiovascular complications are reported. Liver biopsy was carried out
      in 23 of these patients for the purpose of studying the liver histologically. On
      the whole, liver function tests gave normal results: specifically, B.S.F.
      clearance was normal in 91% of the cases and retention at 45' was normal in 77%.
      Histologically, only 9% showed normal liver parenchyma. The vast majority showed
      a varying extent of fat infiltration and in 30% this was also fibrosis. No
      relationship was found to exist between the extent of histological changes and
      B.S.F clearance and retention values.

PMID- 1018813
TI  - [Stenocardia caused by gallbladder disease. Physiopathological and clinical
      findings].
AB  - 10 elderly patients suffering from chronic lithiasic cholecystitis presented
      sporadic attacks of angor during the digestion of rather abundant meals,
      associated or otherwise with biliary colic. A clinical study was carried out in
      order to throw light on the close dependence of pain attacks with cholecystic
      stress. Observations confirmed the possibility that the onset of angor is due to
      reflex coronary vasoconstriction induced through the sympathetic system by
      stimuli arising in the gall bladder. The hypothesis is advanced that coronary
      impairment, however slight, is necessary for such vasoconstriction to be
      possible. Attention is called to the syndromes insofar as removal of the
      irritation in the gall bladder is almost always followed by complete remission of
      the coronary phenomenology.

PMID- 1018814
TI  - [Respiratory function in pectus excavatum in adults and in childhood].

PMID- 1018815
TI  - [Progression of coronary sclerosis demonstrated by repeated coronarography.
      Experience with 80 cases].
AB  - Coronary and left ventricular angiography repeated after an interval of 19 months
      in 84 patients showed progression of coronary sclerosis in 42 and of ventricular
      lesions in 7. No relation between the morphology and seriousness of the initial
      coronary lesions and their progression was noted. No significant differences were
      observed between patients with and without progression as far as the clinical
      data and risk factors (angina pectoris, prior myocardial infarct, cholesterol,
      arterial hypertension, and diabetes) were concerned, though there was a
      significantly higher percentage in obese subjects.

PMID- 1018816
TI  - [The effect of physical exercise on arterial pressure in healthy subjects and in
      cardiopathic patients (coronary and valvular diseases)].
AB  - An optimal working capacity exists for the heart, whether this is healty or
      sclerotic, and this corresponds to an optimal relationship between arterial
      pressure and frequency; in other words, a constant value exists to which arterial
      pressure and pulse rate are correlated.

PMID- 1018818
TI  - [Current considerations on operative obstetrics].

PMID- 1018817
TI  - [Transitory malfunction of an L-Kaster mitral prosthesis. Echocardiographic and
      polygraphic study].
AB  - An unusual instance of transient prosthesis breakdown in a 29-yr-old woman with
      two L-Kaster disk prostheses for mitro-aortic defect is reported. The ECHO and
      polygraphic traces observed during and after breakdown are examined. It is
      considered that the breakdown which occurred in one prostheis only, was
      attributable to a small, internal thrombosis with embolism of the right lower
      extremity.

PMID- 1018819
TI  - [Clinical considerations on 2 cases of secondary abdominal pregnancy].

PMID- 1018820
TI  - ["V.A.C.T.E.R.L.": a new complex of congenital multiple abnormalities as a
      possible consequence of the teratogenic action of exogenous hormones taken during
      pregnancy].

PMID- 1018821
TI  - [The pharyngeal aspirate foam test for determination of neonatal lung maturity.
      Preliminary observations].

PMID- 1018822
TI  - [Clinical evaluation of lysine acetylsalicylate in obstetrical analgesia].

PMID- 1018823
TI  - [The Thierry spatulas: their indication and use].

PMID- 1018824
TI  - [The use of dihydroergotamine and chlorpromazine in labor induction].

PMID- 1018825
TI  - [Preliminary clinical trial of a new nonsteroid anti-inflammatory agent in
      gynecology].

PMID- 1018826
TI  - [Treatment of vaginal trichomoniasis with a new antiprotozoal agent].

PMID- 1018827
TI  - [Use of a "conventional" estro-progestinic drug at low dosage in premenopausal
      and menopausal women].

PMID- 1018828
TI  - [Legal abortion].

PMID- 1018829
TI  - [The use of orciprenaline in labor].

PMID- 1018830
TI  - [Formula of correlation between cephalometry and fetal weight. Echographic
      study].

PMID- 1018831
TI  - [Median episiotomy].

PMID- 1018832
TI  - [Incidence and treatment of dysfunctional metrorrhagias of puberty].

PMID- 1018833
TI  - [Essential mastodynia].

PMID- 1018834
TI  - [Drug therapy of endometriosis].

PMID- 1018835
TI  - [Use of ultrasonics in the 1st trimester of pregnancy].

PMID- 1018836
TI  - [Preliminary note on the clinical significance of the radio-immunological
      determination of luteinizing hormone].

PMID- 1018837
TI  - [Fibroleiomyoma of the ovary].

PMID- 1018838
TI  - [Use of ritodrine in the treatment of premature labor in a limited number of
      cases].

PMID- 1018839
TI  - [Apropos of an unusual fetal malformation causing dystocia].

PMID- 1018840
TI  - [Vulvar carcinoma in the Clinica Ostetrica e Ginecologica of the University of
      Naples. Clinco-statistical findings of a decade].

PMID- 1018841
TI  - [The valve of uterine tamponment in atony during abdominal cesarean section].

PMID- 1018842
TI  - [Diabetes and pregnancy. Calinco-statistical findings in a decade (1963-1973)].

PMID- 1018843
TI  - [Current nosological aspects of puerperal infection. Clinico-statistical study].

PMID- 1018844
TI  - [Study and evaluation of some parameters of uterine contraction obtained with a
      real time automatic procedure].

PMID- 1018845
TI  - [Beta-thalassemia and pregnancy. Case reports and excretion of urinary total
      estrogens].

PMID- 1018846
TI  - [The so-called idiopathic jaundice of pregnancy].

PMID- 1018847
TI  - [Diagnosis of carcinoma of the vulva].

PMID- 1018848
TI  - [A case of iliaco-femoral phlebothrombosis in a pregnant woman with beta
      thalassemia. Cesarean section associated with venous thrombectomy and partial
      interruption of the external iliac vein].

PMID- 1018849
TI  - [A case of hydatidiform mole coexisting with a living, vital fetus].

PMID- 1018850
TI  - [The course of pregnancy after heterologous artificial insemination].

PMID- 1018851
TI  - [Hormonal and surgical treatment of endometrial adenocarcinoma. Long-term follow
      up. Results].

PMID- 1018852
TI  - [Effect of coenzyme A on some gestoses].

PMID- 1018853
TI  - [The climacteric syndrome treated with a non-steroidal estrogen. Clinical
      studies].

PMID- 1018854
TI  - [Ethinodiene 0,5, an estro-progestinic oral contraceptive].

PMID- 1018856
TI  - [Modern problems of the nutrition of pregnant women. Opinion of Professor L.
      Carenza].

PMID- 1018855
TI  - [Abortion or contraception?].

PMID- 1018857
TI  - [Round-table discussion on congenital nephropathies. Introduction].

PMID- 1018858
TI  - [Alport's syndrome].

PMID- 1018859
TI  - ["Congenital and infantile" nephrotic syndrome].

PMID- 1018860
TI  - [Nephronophthisis].

PMID- 1018861
TI  - [The Senior-Loken syndrome. Description of a case].

PMID- 1018862
TI  - [Urate nephropathy in childhood. Lesch-Nyhan disease].

PMID- 1018863
TI  - [Nephrogenic diabetes insipidus. Response to DDAVP and genetic transmission in 2
      family groups].

PMID- 1018864
TI  - [Glomerular lesions and genetic aspects of the de Toni-Debre-Fanconi syndrome].

PMID- 1018865
TI  - [A case of thrombotic obstruction of both renal arteries with secondary anuria].

PMID- 1018866
TI  - [Findings on glycolipid metabolism during and after dialysis with various
      dialysate glucose concentrations (absent, 1g/1, 2g/1)].

PMID- 1018867
TI  - [5 years of experiences with 227 arteriovenous fistulas for hemodialysis].

PMID- 1018868
TI  - [Saphenous vein homologous graft for hemodialytic treatment].

PMID- 1018869
TI  - [Determination of plasma gastrin in patients with chronic uremia undergoing
      hemodialytic treatment].

PMID- 1018870
TI  - [Aspects of glucocorticoid function in patients with uremia undergoing periodic
      hemodialysis].

PMID- 1018871
TI  - [Control of antibiotic neurotoxicity in patients under hemodialysis].

PMID- 1018872
TI  - [Dialysis community. Soci-psychological findings and organization problems].

PMID- 1018873
TI  - [Short dialysis in the old patient. Clinical and technological problems].

PMID- 1018874
TI  - [Dialysis in the old patient].

PMID- 1018875
TI  - [Dialysis in high risk patients. Problems and results].

PMID- 1018876
TI  - [High levels of digoxin encountered in patients with chronic uremia undergoing a
      periodic hemodialytic treatment and conservative therapy].

PMID- 1018877
TI  - [1 year of clinical experience with high flow, short-term peritoneal dialysis].

PMID- 1018878
TI  - [Serum oxalate changes in patients undergoing hemodialysis and treated with
      succinimide].

PMID- 1018879
TI  - Lipids of human and equine smegma.
AB  - The lipids of human and equine smegma pools were saponified and the total fatty
      acids submitted to temperature programmed gas chromatography (GC) analysis. In
      contrast to the human products, the horse smegma fatty acids contained very low
      odd saturated as well as olefinic branched chain acid contents. The cyclopropane
      fatty acid, 9,10-methyleneoctadecanoic acid, occurred in smegma sampled from men
      over 35 years of age but could not be detected in the pool from persons of 17-20
      years of age nor in any of the equine mixtures. The alcoholic fraction from horse
      smegma contained about 85% sterol, the remainder constituting alcohols of C12 to
      C28 and of which 43.5% were branched chain components. The corresponding product
      from human smegma was primarily sterol. Squalene comprised the main hydrocarbon
      present in smegma of either species.

PMID- 1018880
TI  - The ultrastructure of a poorly differentiated adenocarcinoma of the human tuba
      uterina.
AB  - A poorly differentiated adenocarcinoma of the human oviduct was studied by light
      and transmission electron microscopy. Cells contained abundant mitochondria,
      bound and free ribosomes, prominent Golgi's bodies and aggregates of membrane
      bound dense bodies. The small glandular lumina with numerous microvilli were
      generally devoid of cilia and contained secretory material. The neoplasm was
      ultrastructurally similar to poorly differentiated ovarian serous carcinomas.

PMID- 1018881
TI  - Pharmacokinetic studies in the chemotherapy of neuroblastoma using the C1300
      murine system.
AB  - The transplantable C1300 murine neuroblastoma has been characterized
      biochemically and an in vivo model for the screening of new therapeutic
      approaches to the treatment of neuroblastoma developed. Subcutaneous inoculation
      of A/J mice with 10)6) C1300 cells results in predictable tumor growth and animal
      death in 25 +/- 4 days. Tumor growth is Gompertzian, correlates with increases in
      tumor RNA and DNA content and with the rate of tumor DNA synthesis as measured by
      [3H] thymidine incorporation. The model proposed is based on the degree to which
      various therapeutic options are able to inhibit tumor DNA synthesis, and these
      observations have been confirmed autoradiographically. A single course of either
      cyclophosphamide (25, 50, 100 or 200 mg/kg), BCNU (2, 7.5, 15, or 30 mg/kg) or
      cytosine arabinoside (15, 30, 60, 90 mg/kg) resulted in dose-related inhibition
      of tumor DNA synthesis. The maximum decline in DNA synthesis that was produced by
      the highest dose of each agent was by 81%, 77% and 68% of untreated tumor values
      respectively. Adriamycin, however, even at lethal levels (10 mg/kg), did not
      elicit significant inhibition of tumor DNA synthesis. Radiotherapy (200 R, 500 R
      or 1000 R) also produced graded inhibition of tumor DNA synthesis. This model is
      potentially useful for the preclinical screening of therapuetic options in the
      treatment of neuroblastoma. Thus, single agent therapy, combination chemotherapy
      and combined radiotherapy and chemotherapy may be rapidly evaluated for possible
      clinical use.

PMID- 1018882
TI  - Survival data from a multiphasic mobile cancer detection unit.
AB  - Individuals with early cancer rarely have symptoms, through it is at this state
      that the best prognosis can be afforded. 22 out of 5,232-patients screened in a
      Mobile Cancer Detection Unit (MCDU) received cancer diagnosis (exclusive of skin
      cancer). These patients have enjoyed much greater survival than expected. For
      instance, only three have died versus and expected 7.5. Calculations show that if
      all cancer patients in the United States had a similar increase in survival, then
      the lives of at least 120,000-persons could be extended each year. These limited
      data must be interpreted cautiously. Nevertheless, they do hold promise since
      only a few percentage points increase in survival when measured against the full
      impact of the cancer problem will show significant patient benefit.

PMID- 1018883
TI  - Metamorphic changes in Anuran muscles following thyroxine treatment.

PMID- 1018884
TI  - Development and growth of the tooth germs of rats.

PMID- 1018885
TI  - Regeneration of olfactory bioplar neurons in the normal olfactory epithelium of
      the adult bat.

PMID- 1018886
TI  - Electron microscopic study on the newt parathyroid gland after administration of
      agents affecting autonomic nerves.

PMID- 1018887
TI  - Immunization of mice and calves against Salmonella dublin with attenuated live
      and inactivated vaccines.
AB  - Previous findings, viz. that mice can be successfully immunized against infection
      with Salmonella dublin with either live or inactivated vaccine, were confirmed.
      Immunity lasted for at least 12 weeks in mice which had been immunized with
      inactivated alum-precipitated vaccine. The immunogenicity of inactivated vaccine
      gradually decreased on storage at 4 degrees C, but this was only detectable if a
      single injection was used for immunization: 2 injections virtually eliminated
      this phenomenon. The immunogenicity of live vaccine in mice was not enhanced by
      levamizole or the simultaneous injection of inactivated organisms. Both live and
      inactivated vaccines provided immunity in calves. A single injection of
      lyophilized vaccine, prepared from live rough Salmonella dublin strain (HB
      1/17),protected 3 out of 6 calves, while 2 injections of a formalin-inactivated,
      alum-precipated vaccine, containing 1% packed cells of S. dublin strain 2652 V,
      protected 5 out of 6 calves against intraduodenal challenge with 2 x 10(9), S.
      dublin strain 2652 V. Two calves which had been immunized with an inactivated oil
      adjuvant vaccine were also solidly immune to this challenge. Serum antibody
      response in calves was poor when measured by the tube agglutination and the
      haemagglutination tests. Similarly, the sera had only marginal protective values
      when tested by means of a passive protection test in mice. Antibody titres alone
      are not a valid measure therefore, for the immune status of immunized animals.

PMID- 1018888
TI  - The isolation of Mycoplasms synoviae from chickens with infectious synovitis and
      air-sacculitis in the Republic of South Africa.
AB  - Mycoplasma synoviae was isolated from the trachea of chickens showing either
      typical infectious synovitis lesions or air-sacculitis. M. synoviae was
      identified by means of the direct plate fluorescent antibody technique and its
      growth-dependence on nicotine-amide-adenine dinucleotide. This is the first
      documented report on the isolation and identification of M. synoviae in the
      Republic of South Africa.

PMID- 1018889
TI  - Studies on schistosomiasis. 8. The influence of age on the susceptibility of
      sheep to infestation with Schistosoma mattheei.
AB  - Twenty-eight Dorper wethers, allocated according to age into 4 groups of 7
      animals each, and 1 group of 7 Merino wethers, were compared for susceptibility
      to Schistosoma mattheei infestation. The group mean ages of the Dorper sheep
      varied from 5-61 months and their live mass from 25-66 kg, while the Merinos were
      8 months old and had a mean mass of 19 kg. Despite the marked differences in the
      age and live mass of the Dorper sheep and the inclusion of 2 breeds in the
      experiment, no statistically significant differences were found in cercariae
      which failed to penetrate the sheep the mean percentage development of cercariae
      to adult worms, worm distribution in the mesenteric and gastric radicles of the
      portal vein and the pulmonary arterial system, and worms not removed by
      perfusion. Significant differences between groups (5% significance level) were
      found, however, in the number of worms recovered from the hepatic portal system,
      and in the worm sex ratio. On 3 occasions the total number of eggs excreted per
      female schistosome in the mesentery per 24 hours differed significantly between
      groups, but each time a different group or groups of sheep were responsible for
      the variation which was probably due, therefore, not to the age or breed of the
      sheep, but to daily variations in individuals. Highly significant differences
      occurred in the infectivity of the 6 cercarial pools used for infestation in
      spite of standardized collection and handling of the cercariae. Possible reasons
      for this are discussed and a solution suggested. Frequent egg counts (5 per sheep
      per week) were done during the first 25 days of patency, until the sheep were
      slaughtered. Schistosome ova were detected in the faeces of only 1/18 sheep
      examined on Day +43 after infestation, and 3/17 on Day +44, whereafter this
      increased rapidly to 15/34 on Day +45, 25/33 on Day +46, etc. A highly
      significant correlation was found between the total worm egg excretion in the
      faeces of the sheep per day and the numbers of female schistosomes in the
      mesentery, especially shortly after the onset of egg production.

PMID- 1018890
TI  - Observations on the transmission, immunology, clinical signs and chemotherapy of
      dourine (Trypanosoma equiperdum infection) in horses, with special reference to
      cerebro-spinal fluid.
AB  - This paper is a record of observations on the transmission and clinical signs of
      dourine in naturally infected cases of known duration, and of temporal and
      quantitative aspects of the immune response in blood and cerebro-spinal fluid.
      Included in the record are observations on the presence of Trypanosoma equiperdum
      parasites in these body fluids and methods for their detection. There is evidence
      that the occurrence of nervous symptoms and lesions in infected horses is
      associated with the presence of Trypanosoma equiperdum parasites in cerebro
      spinal fluid. The suitability of cerebro-spinal fluid as an environment for the
      parasite and its relationship with nervous manifestations of the disease are
      discussed. Observations support the previously reported lesions of peripheral
      polyneuritis and suggest a possible correltation between the consitstent position
      of the nervous lesions and the drainage of cerebro-spinal fluid containing the
      parasite. Chemotherapy with an experimental drug MSbE was used with varying
      results in 4 horses at different stages of infection.

PMID- 1018891
TI  - Maldronksiekte in cattle: a neuronopathy caused by Solanum kwebense N.E. Br.
AB  - A neurological disease of cattle (maldronksiekte), occurring in a localized area
      of the Northern Transvaal, was experimentally reproduced by feeding Solanum
      kwebense plants to cattle. The disease is characterized by temporary loss of
      balance and transient epileptiform seizures precipitated by a variety of stimuli,
      such as exercise, handling (dipping, loading, etc) and fright. When not
      disturbed, most affected animals appear to be completely normal. The most
      conspicuous histopathological lesion is a neuronopathy manifested by vacuolar
      degeneration and eventual necrosis of neurones, particularly of the Purkinje
      cells in the cerebellum. An atrophy of the cerebellar cortex is seen grossly. The
      history, clinical signs and experimental reproduction of the disease, as well as
      the pathology of 4 experimental and 18 natural cases, are described.

PMID- 1018892
TI  - Cerebral babesiosis in a new-born calf.
AB  - A case of intra-uterine transmission of Babesia bovis is reported. The calf was
      born normally but showed signs of intravascular haemolysis and nervous
      involvement 24 h after birth. It died shortly afterwards from cerebral
      babesiosis. The dam was not clinically affected.

PMID- 1018893
TI  - [Research results for the 9th Five-Year Plan on the USSR problem of "Trauma,
      Traumatism and Orthopedic Diseases"].

PMID- 1018894
TI  - [Suppurative complications in open diaphyseal fractures of the bones of the leg].

PMID- 1018895
TI  - [Compression-distraction osteosynthesis in the treatment of pseudarthroses of the
      femur].

PMID- 1018896
TI  - [Late results of the surgical treatment of chronic gunshot and hematogenic
      osteomyelitis of the extremities].

PMID- 1018897
TI  - [Treatment of diaphyseal defects of the bones by a distraction-compression
      method].

PMID- 1018898
TI  - [Movement recovery in the process of treating ununited and united fractures using
      the Volkov-Oganesian hinged distraction apparatus].

PMID- 1018899
TI  - [Complications and outcomes of the compression-distraction osteosynthesis of
      fractures and pseudarthroses of the long, tubular bones].

PMID- 1018900
TI  - [Reosteosynthesis of the tibia].

PMID- 1018901
TI  - [Initial results of using antilymphocyte globulin for treating infectious
      nonspecific polyarthritis in children].

PMID- 1018902
TI  - [Electromyography of the muscles of the foot and leg in rheumatoid arthritis].

PMID- 1018903
TI  - [Assessment of the frequency of osteogenesis imperfecta among the populations of
      Moscow and Kiev].

PMID- 1018904
TI  - [Dynamics of the bioelectrical activity of the muscles of the lower extremities
      during the surgical treatment of osteochondrosis of the lumbar spine].

PMID- 1018905
TI  - [Mechanisms of the rotary motions of the human pelvis and spine during walking].

PMID- 1018906
TI  - [Role of medical gymnastics and physical factors in the rehabilitative treatment
      of diaphyseal fractures of the bones of the crus].

PMID- 1018907
TI  - [Primary disability from injuries to the locomotor apparatus in collective
      farmers].

PMID- 1018908
TI  - [Use of a gelatin sponge for replacement of the cavity following sequestrectomy].

PMID- 1018909
TI  - [Diagnosis and treatment of acute hematogenic osteomyelitis in children].

PMID- 1018910
TI  - [Interrelationship of the vessels of the osteomyelitic cavity and of the
      transplantated muscle after experimental necrectomy].

PMID- 1018911
TI  - [Expediency of utilizing new transplantation terminology in orthopedica and
      traumatology].

PMID- 1018912
TI  - [Treatment of pseudarthroses of the femur].

PMID- 1018913
TI  - [Instrument for puncture biopsy].

PMID- 1018914
TI  - [Cutting pliers for the hardware used in traumatology and orthopedics].

PMID- 1018915
TI  - [Combination instrument for osteoplastic operations].

PMID- 1018916
TI  - [Protection of lower airways following horizontal laryngectomy.
      Roentgenokymographic studies].

PMID- 1018917
TI  - [Anatomy of the larynx in newborn infants and infants. Selected problems
      (preliminary communication)].

PMID- 1018918
TI  - [Incidence of laryngeal carcinoma in the Poznan area and the Zielona Gora
      province].

PMID- 1018919
TI  - [Side effects following laryngography].

PMID- 1018920
TI  - [Diagnosis of congenital cervical cysts and fistulae].

PMID- 1018921
TI  - [Classification of mucosal syndromes].

PMID- 1018922
TI  - [Value of diagnostic tests in the detection of sensitization to grass pollens in
      allergological practice].

PMID- 1018923
TI  - [Topical corticotherapy in allergic diseases of the upper airways].

PMID- 1018924
TI  - [Collagen content in auditory ossicles in otosclerosis and in controls].

PMID- 1018925
TI  - [Bednar's storiform neurofibroma].

PMID- 1018926
TI  - [Eosinophilic granuloma of the frontal bone].

PMID- 1018927
TI  - [Case of idiopathic fibrous choanal atresia].

PMID- 1018928
TI  - [Paroxysmal vertigo in a case of widely open auditory tubes].

PMID- 1018929
TI  - [Lingual hemangiopericytoma].

PMID- 1018930
TI  - [Case of neck neurilemmoma in a child].

PMID- 1018931
TI  - [Current views on the physiology and pathology of the auditory tube].

PMID- 1018932
TI  - [Main results and perspectives of parasitological research].

PMID- 1018933
TI  - [Main achievements in the study of immunology of helminthiasis].
AB  - Analysis of available literature has shown a considerable progress in the
      research of the immunology of helminthoses during recent years. In the Soviet
      Union the study of this problem is carried out, though to a lesser extent, in the
      same directions as in other countries. They are as follows: 1. study of
      manifestation, degree of intensity and mechanisms of immunity; 2. study of
      antigenic structure of helminths as a basis for a purposeful search of methods of
      cleaning antigenes from ballast matters and criterium of taxonomy; 3. elaboration
      of methods for immunodiagnostics of helminthoses; 4. use of immunological methods
      for a study of epidemiology of helminthoses (seroepidemiology); 5. study of
      immunopathology.

PMID- 1018934
TI  - [Distance orientation of the tick Ixodes persulcatus to the attractant factors of
      the prey].
AB  - The laboratory and field tests have shown that the odour is the main factor which
      activates ticks (Ixodes persulcatus) attraction to the host. Ticks have a
      sensation of a man on 15 metres distance; the number of activated ticks increases
      with the distance to the host and depends on the wind direction. The infrared
      radiation source excites only a short time activation of the ticks on 0.5-1.0
      metres distance. Mechanic and sound stimulations were found to be uneffective for
      the ticks in the experiment.

PMID- 1018935
TI  - [Density and distribution of pasture Ixodes in the Central Sikhote-Alin].
AB  - Data are given on the density of active ticks in different landscapes in the
      central part of Sikhote-Alin. The character of the ticks distribution (regular,
      even, contagious) in dependence on the relief and vegetation is analysed.

PMID- 1018936
TI  - [Polytypical species of mosquitoes. 1. Anopheles hyrcanus (Passas, 1771)].
AB  - An. hyrcanus differs from close An. sinensis Wied. from south-eastern Asia in the
      following characters: colour of palps and wings, scales of hind abdominal
      sternites (Table 1). Populations of An. hyrcanus from various regions of the
      Soviet Union display great variability of systematic characters. The comparison
      of specimens from the western and eastern parts of the distribution area has
      shown that the difference between them is negligible and unstable (Table 2). We
      have no reason to assign An. hyrcanus from the Far East of the USSR to a distinct
      subspecies.

PMID- 1018937
TI  - [Developmental periods and adaptation of parthenites of Eurytrema pancreaticum
      (Dicrocoeliidae, Trematoda) to environmental conditions].
AB  - Data are given on the developmental periods of parthenites of E. pancreaticum
      (Janson, 1889) from the Far East of the USSR. The growth and formation of
      parthenites were found to take place from May to October and to coincide with the
      active period of the intermediate host's life cycle. With the decrease of autumn
      temperatures to 8 degrees the growth of parthenites slows down and ceases
      completely in October. The pause in the development of parthenites from October
      to April causes longer developmental periods of parthenites as compared to those
      in the regions of tropical and subtropical climate. Under laboratory conditions
      at a temperature of 8 to 22 degrees the development of parthenites proceeds
      without any intervals within 6.5 months.

PMID- 1018938
TI  - [Life cycles of the Hymenolepis, Aploparaksis birulai Linstow, 1905 and
      Aploparaksis brachyphallos (Krabbe, 1869)].
AB  - Larvae of A. birulai from Lumbriculus variegatus and A. brachyphallos from
      Stylodrilus sp. from the Chauna lowland (Chukotka) are described. The species
      belonging of the larvae was proved experimentally. It was shown that Cysticercus
      sp. Hrabe, 1958 is a larvacyst of A. birulai. For larvacysts of A. birulai type
      the name of "floricerk" was suggested and for those of A. brachyphallos type--the
      name "tailed diplocyst". It is noted that A. uelcal Spassky et Jurpalova, 1968 is
      a synonym of A. brachyphallos (Krabbe, 1869) nec A. brachyphallos sensu Davies,
      1938.

PMID- 1018939
TI  - [Peritrophic membrane of the 2d type in females of the genus Aedes].
AB  - In the females of bloodsucking mosquitoes of the genus Aedes there was recognised
      a secretory activity of the cells of the external wall of the cardial portion of
      the intestine. The secretion excreted according to the macroapocrine type forms
      in the cardial cavity a peritrophic membrane of the 2-nd type. A difference in
      the development rate of the membrane in the species studied was noted.

PMID- 1018940
TI  - [Revision of certain holarctic species and subspecies of mosquitoes of the genus
      Culiseta felt. 1. Culiseta (Culiseta) kanayamensis Yamada as a synonym of C. (C.)
      bergrothi Edwards].
AB  - The arguments are given in favour of the identity of two mosquito species,
      Culiseta bergrothi Edwards, 1921 and C. kanayamensis Yamada, 1932; the latter
      name should be considered as a synonym of the former according to the author's
      priority. A map of the geographic distribution of C. bergrothi (= C.
      kanayamensis) is given in which the association of this mosquito with the taiga
      zone of the Palaerctic is shown.

PMID- 1018941
TI  - [Gonotrophic cycle of Leptoconops borealis (Diptera, Ceratopogonidae)].
AB  - Data are given concerning the gonotrophic cycle in fully engorged specimens of
      Leptoconops borealis, a mass blood sucker from the coast of the sea of Azov. In
      fully engorged females the repetition of gonotrophic cycles and degeneration of
      ovaries take place under the effect of Mermitoidea parasitism.

PMID- 1018942
TI  - [New species of the tick, Haemoganasus (Parasitiformes, Gamasoidea)].
AB  - The female of the new species Haemogamasus bujakovi sp. n. is described from the
      Tungokochen region of the Chita district. Two females of the mite were taken from
      Apodemus speciosus and one from Clethrionomys rutilus.

PMID- 1018943
TI  - The cardiac conduction system in sudden infant death syndrome: a report on three
      cases.
AB  - The cardiac conduction systems in three cases of sudden infant death syndrome
      (SIDS) were compared with those in children dying from known causes. Foci of
      inflammatory cells and areas of necrosis were found in SIDS. Lymphocytes and
      eosinophils were counted in the adjacent myocardium and significantly larger
      numbers were present in SIDS. These parhological changes in the conduction
      systems may be capable of producing cardiac arrhythmia and sudden death.

PMID- 1018944
TI  - Routine freezing of red blood cells for transfusion in Western Australia.
AB  - Experience with preservation of red cells for transfusion since 1971 has shown
      that refrigeration with liquid nitrogen is simple and reliable. It allows the use
      of a concentration of glycerol (20%) which can reasonably be removed by batch
      washing if automated washing is not possible. It is possible to transport cells
      frozen in liquid nitrogen over long distances. This appears the method of choice
      for preserving rare blood, and once adopted for this purpose it is logical to use
      it for storage of red cells for other patients. Red cells so stored are similar
      in many respects to fresh cells, and more than 600 units have been transfused
      since 1971 without any adverse reaction.

PMID- 1018945
TI  - Mycobacterium fortuitum spinal infection: case report.
AB  - Acute paraplegia followed a vertebral infection with Mycobacterium fortuitum.
      There was a satisfactory response to surgery and antibiotics. No predisposing
      factors for this primary bone infection could be found.

PMID- 1018946
TI  - Cerebrospinal fluid fructose-biphosphate aldolase (aldolase) activity in
      infectious diseases of the central nervous system.
AB  - Aldolase levels were estimated in the cerebrospinal fluid of patients with
      infectious diseases of the central nervous system. A significant rise was found
      in bacterial and cryptococcal meningitis but the investigation failed to
      elucidate the source and clinical significance of the elevated activity.

PMID- 1018947
TI  - Diagnosis: hairy cell leukemia.

PMID- 1018948
TI  - Antibody detection and identification in a hospital blood bank.
AB  - A six-year serological survey has demonstrated that an average of 2.2% per annum
      of individuals requiring compatibility testing possessed antibodies de novo and
      that the frequency for individuals forming antibodies following transfusion is
      4.1%. The increased detection rate from 1.5% (1969) to 4.1% (1971-5) was almost
      entirely due to the sensitivity of the two-stage papain technique; a total of 124
      antibodies were detected only in this test. Three of these enzyme-active
      antibodies were found to be the cause of mild haemolytic transfusion reactions.
      Since 60% of the listed 332 alloantibodies were Rh-specific, the transfusion of
      appropriately Rh phenotyped blood is strongly recommended.

PMID- 1018949
TI  - Hereditary elliptical stomatocytosis: a case report.
AB  - The case described demonstrates the development of elliptical stomatocytosis in a
      neonate and the appearance of elliptical stomatocytes in her mother whose blood
      film, before delivery, showed elliptocytosis. Further investigations on both
      individuals indicated a mild haemolytic anaemia. To our knowledge this is the
      second reported case of elliptical stomatocytosis.

PMID- 1018950
TI  - The detection of myoglobin in urine and its application to the diagnosis of
      myocardial infarction.
AB  - An indirect haemaglutination method was developed for the immunochemical
      detection of myoglobin in human urine. Myoglobin was found in the urine of 84% of
      44 patients with acute myocardial infarction. In contrast, it was detected in the
      urine of 2.7% of 147 control subjects and in none of a control group of 15
      patients who had received intramuscular injections. In patients with myocardial
      infarction, myoglobin was detected in most but not all urine specimens collected
      between 10 and 50 hours after the onset of chest pain. The results suggest that
      the detection of myoglobin in urine may be a valuable addition to present tests
      for the diagnosis of acute myocardial infarction.

PMID- 1018951
TI  - Bone marrow metastases in disseminated alveolar rhabdomyosarcoma: case report
      with ultrastructural study and review.
AB  - A case of desseminated alveolar rhabdomyosarcoma in an 18-year-old male with
      leuco-erythroblastic anaemia is described. Numerous bizarre malignant cells,
      including frequent multinucleated giant cells, were seen in bone marrow
      aspirates, and osteolytic lesions appeared late in the clinical course. The
      primary site of the neoplasm remained undertermined during life and also at
      necropsy, which revealed minute pulmonary metastases and extensive lymph nodal,
      pleural and skeletal deposits. The diagnosis was confirmed on necropsy tissue by
      ultrastructural examination which demonstrated numerous thin (5 nm) and thick (15
      nm) intracytoplasmic filaments in tumour cells, sometimes organized in bundles;
      scattered dense Z-band-like bodies, and rod-shaped structures were also seen. The
      fine structure of the rhabdomyosarcoma in the present case is compared with
      previous ultrastructural studies. Elongated, thick intracytoplasmic filaments
      whose diameter corresponds to that of myosin myofilaments are strong evidence for
      rhabdomyoblastic differentiation and are considered to be the sine qua non of a
      positive electron microscopic diagnosis of rhabdomyosarcoma. Orgaized bundles of
      filaments and Z-band-like dense bodies are usually present, and rod-shaped
      structures are found infrequently, but none of these are necessary for the
      ultrastructural diagnosis.

PMID- 1018952
TI  - [Intravascular erythrocyte aggregation in the microcirculation region in
      traumatic shock].

PMID- 1018953
TI  - [Dynamics of changes in microcirculation in acute blood loss and massive blood
      transfusion in rats].

PMID- 1018954
TI  - [Respiratory indicators and blood gases during transfusion of massive doses of
      homologous blood under experimental conditions].

PMID- 1018955
TI  - [Study of certain biophysical and biochemical indicators in the process of
      development of chronic experimental hepatitis].

PMID- 1018956
TI  - [Effect of conservative therapy on the activity of enzymes and bioenergetic
      processes in the liver in acute experimental pancreatitis].

PMID- 1018957
TI  - [Effect of 6-months' hypokinesia in dogs on the mineral component, bone
      regeneration and mechanical properties of the bone tissue].

PMID- 1018958
TI  - [Effect of neonatal thymectomy on blood protein composition and the state of
      lymphoid tissue].

PMID- 1018959
TI  - [Causes of death of rabbits in the state of artificial hypobiosis].

PMID- 1018960
TI  - [Certain aspects of carbohydrate-phosphorus metabolism during dying and
      resuscitation of the body in burns and lethal blood loss].

PMID- 1018961
TI  - [Characteristics of the state of the blood vessels and impedance in the
      hypothalamus and Ammon's horn and certain vegetative reactions in high altitude
      hypoxia].

PMID- 1018962
TI  - [Experimental therapy of periodontosis with elastase inhibitor].

PMID- 1018963
TI  - [Parasympathetic atrioventricular block and its electrocardiographic signs].

PMID- 1018964
TI  - [Effect of elastase on arterial pressure].

PMID- 1018965
TI  - [Mechanism of the effect of small dose of adrenaline on the resistance of the
      heart to hypoxia].

PMID- 1018966
TI  - [Mechanism of respiratory discomfort caused by hypercapnia].

PMID- 1018967
TI  - [Mechanism of reaction of the pituitary-adrenal system to stress effect of
      alternating magnetic field].

PMID- 1018968
TI  - [Effect of single intramuscular administration of monodoses of pyrogenal on the
      glucocorticoid function of the adrenal cortex in healthy persons].

PMID- 1018969
TI  - [Comparison of the degree of initiated chemiluminescence and the activity of
      blood serum enzymes in acute hepatic insufficiency in dogs].

PMID- 1018970
TI  - [Mechanism of development of reserpine-induced destruction of the gastric
      mucosa].

PMID- 1018971
TI  - [2 forms of determination of biological processes as the cause of their
      discreteness and continuity].

PMID- 1018972
TI  - [Practical work on the subject "pathology of the electrolyte metabolism"].

PMID- 1018973
TI  - [Granulomatous giant-cell endometritis due to talc].

PMID- 1018974
TI  - [Experimental study on the role of pineal body in the skeletal growth of the
      rat].

PMID- 1018975
TI  - Preliminary considerations on the identity of first and second-type alveolar
      cells in the human lung.

PMID- 1018976
TI  - [Studies on the possible contamination of transfer factor preparations with
      bacterial endotoxins].

PMID- 1018977
TI  - [Pulmonary carcinoma (microcytoma) with metastases in liver angiomas
      (cavernomas)].

PMID- 1018978
TI  - [Electron microscopy in the diagnosis of pleural mesothelioma].

PMID- 1018979
TI  - [Unusual tumors of the nervous system: olfactory neuroblastoma (report on 5
      cases)].

PMID- 1018980
TI  - [Toxoplasmic lymphadenopathy (Piringer-Kuchinka lymphadenitis)].

PMID- 1018981
TI  - [A case of type II congenital dyserythropoietic anemia. Clinico-hematologic and
      anatomo-histological study].

PMID- 1018982
TI  - [Cutaneous reactivity to the so-called "recall" antigens in 4 patients with
      Burkitt's African lymphoma].

PMID- 1018983
TI  - [Ultrastructural morphological findings in hepatic biopsies of patients with
      serious obesity treated with jejuno-ileal shunt].

PMID- 1018984
TI  - [Undifferentiated carcinoma of the thyroid with spindle cells and giant cells of
      osteoclastic aspect].

PMID- 1018985
TI  - [Pathology of the hormonal contraceptive agents].

PMID- 1018986
TI  - [Ultrastructure of a granulosa-cell tumor].

PMID- 1018987
TI  - [Primary amyloidosis of the heart (anatoma-clinical contribution)].

PMID- 1018988
TI  - [Statistical study on various clinical and histological parameters of Hodgkin's
      disease].

PMID- 1018989
TI  - [Anatomo-clinical study on a case of bronchopulmonary sarcoidosis].

PMID- 1018990
TI  - End stage renal failure with syndrome of "malignant" hypertension in scleroderma.
      Report of a case treated by bilateral nephrectomy.

PMID- 1018991
TI  - [Sympathetic ophthalmia with onset after a long interval following 2 successive
      eye injuries].

PMID- 1018992
TI  - [Polycythemia vera in childhood. Data on platelet function and blood coagulation
      factors].

PMID- 1018993
TI  - [Data on statural growth and skeletal maturation in thalassemia major as related
      to blood transfusion therapy].

PMID- 1018994
TI  - [Adenosine deaminase activity of the blood in children with various diseases].

PMID- 1018995
TI  - [Embryopathy (vaccinic?), congenital toxoplasmosis and neuroblastoma].

PMID- 1018996
TI  - [Eosinophilic meningitis in childhood. Description of a case].

PMID- 1018997
TI  - [Monosomy C with mosaicism and thymic dysplasia].

PMID- 1018998
TI  - [Diagnosis of cardiovascular disorders in severe forms of pneumonia in children
      under 1 year of age].

PMID- 1018999
TI  - [Alkalosis and hypokalemia in severe forms of pneumonia in young children].

PMID- 1019000
TI  - [Hypoosmosis in respiratory insufficiency of young children].

PMID- 1019001
TI  - [Adenylic acids of blood in young children with pneumonia with asthmatic
      component].

PMID- 1019002
TI  - [Urgent problems of treatment of respiratory diseases in children].

PMID- 1019003
TI  - [Vitamin B 1 content in the body according to the results of load tests with
      thiamine and cocarboxylase in young children with acute pneumonia].

PMID- 1019004
TI  - [Changes in the lungs in sudden death of infants with septicemia].

PMID- 1019005
TI  - [Use of seismocardiography in the examination of healthy infants and young
      children].

PMID- 1019006
TI  - [Projection of the pericardium on the anterior thoracic wall in infants].

PMID- 1019008
TI  - [Classification of chronic nutrition disorders in young children].

PMID- 1019007
TI  - [Classification of chronic nutrition disorders in young children].

PMID- 1019009
TI  - [Working classification of chronic nutrition disorders in young children
      (contribution to discussion)].

PMID- 1019010
TI  - [Effect of the fat component of food on the content of blood serum lipids in
      young children].

PMID- 1019011
TI  - [Composition of human milk of mothers of infants with excessive weight].

PMID- 1019012
TI  - [Iron metabolism in healthy infants].

PMID- 1019013
TI  - [Certain results of prevention of iron deficiency anemia in young children].

PMID- 1019014
TI  - [Classification and pathogenesis of D-hypervitaminosis in children].

PMID- 1019015
TI  - [Concerning the article by N.A. Barlybaeva and V.I. Strukov "Classification of D
      hypervitaminosis in children"].

PMID- 1019016
TI  - [Classification of D-hypervitaminosis].

PMID- 1019017
TI  - [Characteristics of rickets, anemia and development of premature infants after
      active preventive measures under polyclinical conditions].

PMID- 1019018
TI  - [Immediate and remote results of treatment of congenital pyloric stenosis in
      children].

PMID- 1019019
TI  - [Characteristics of physical training of preschool children considering the type
      of the nervous system].

PMID- 1019020
TI  - [Effect of rifle shooting on children's body].

PMID- 1019021
TI  - [Characteristics of the function of external respiration in different tempo of
      growth of adolescents].

PMID- 1019022
TI  - [Age-specific characteristics of tissue metabolism during physical exertion and
      in the period of restoration].

PMID- 1019023
TI  - [Complications after anti-tuberculosis intradermal vaccination and possibilities
      of their surgical treatment].

PMID- 1019024
TI  - [Clinico-morphological aspects of acute pneumonia in children].

PMID- 1019025
TI  - [State of health of school-children in rural areas].

PMID- 1019026
TI  - [Comparative analysis of the indicators of hemodynamics in healthy school
      children according to the data of 1967 and 1975].

PMID- 1019027
TI  - [Characteristics of rheoencephalogram and rheovasogram in healthy children of
      school age].

PMID- 1019029
TI  - [Joint activity of the authorities of public health and school health education].

PMID- 1019028
TI  - [State of various endocrine glands and obesity in school-children].

PMID- 1019030
TI  - [Hygienic problems of the organization of leisure time of school-children].

PMID- 1019031
TI  - [Urgent problems of school health].

PMID- 1019032
TI  - [Dispensarization of school-children under conditions of a school for general
      education].

PMID- 1019033
TI  - [Role of a school physician and district pediatrician in the detection of hearing
      disorders in children].

PMID- 1019034
TI  - [Work of the sanatorium pioneer camps of the Krasnoyarsk Territory].

PMID- 1019035
TI  - [Polyposis and polyps of the large intestine in children].

PMID- 1019036
TI  - [Hazards of puncture and long-term catheterization of the subclavian vein in
      children].

PMID- 1019037
TI  - [Importance of roentgenological methods of examination in the diagnosis of
      urologic diseases in children].

PMID- 1019038
TI  - [Large-frame cystourethrofluorography in the diagnosis of urologic diseases in
      children].

PMID- 1019039
TI  - [Diagnosis of malformations of the kidneys and the urinary tract in infants].

PMID- 1019040
TI  - [Prevalence of mucoviscidosis and its role in recurrent and chronic broncho
      pulmonary diseases in Latvia].

PMID- 1019041
TI  - [Role of radiotherapy in the management of primary, radiosensitive bone tumors
      diagnosed as Ewing's sarcoma].

PMID- 1019042
TI  - [Chemotherapy in bone tumors].

PMID- 1019043
TI  - [Results of chemotherapy in Ewing's sarcoma].

PMID- 1019044
TI  - [Role of surgical treatment of primary, radiosensitive bone tumors].

PMID- 1019045
TI  - [Criteria, types and symptoms of local cure of radiosensitive malignant bone
      tumors in the course of radiotherapy].

PMID- 1019046
TI  - [Round-table conference: Ewing's sarcoma in children].

PMID- 1019047
TI  - [Clinical characteristics of cases of Ewing's sarcoma based on an analysis of the
      history of patients examined at the outpatient Department of Warsaw Institute of
      Oncology in the years 1947-1973].

PMID- 1019048
TI  - [Radiologic differential diagnosis of Ewing's sarcoma].

PMID- 1019049
TI  - [Malignant round cell tumors of bone in the records of the Department of
      Pathology of the Warsaw Institute of Oncology].

PMID- 1019050
TI  - [Scintigraphic examination of bone tumors].

PMID- 1019051
TI  - [Interactions between antibacterial drugs].

PMID- 1019052
TI  - [Eosinophils: their structure, function and clinical evaluation].

PMID- 1019053
TI  - [Lysozymes and their role in clinical medicine].

PMID- 1019054
TI  - [Use of digital computers in the analysis and classification of chromosomes].

PMID- 1019055
TI  - [Cytogenetic characteristics of Syrian hamster tumor TuHl].

PMID- 1019056
TI  - [Elastin structure and metabolism under physiological and pathological
      conditions].

PMID- 1019057
TI  - Management of thyroid disease: with particular reference to thyroid nodules.
AB  - A host of expensive thyroid tests and operations could be avoided if aspiration
      biopsy of thyroid nodules were more widely accepted by American physicians. The
      procedure is both an accurate diagnostic tool and an effective treatment of many
      thyroid nodules.

PMID- 1019058
TI  - Introduction: hip and leg problems in children.

PMID- 1019059
TI  - Congenital hip dislocation: before and after walking age.
AB  - Residual morbidity from congenital dislocation of the hip is for the most part
      preventable. Prevention is possible, however, only by establishing the diagnosis
      early and undertaking treatment which leads to stable reduction and avoids
      complications. To attain these goals, hip examination whould be a routine part of
      all newborn care. When dislocation is found in a newborn and early treatment
      initiated, the anatomic abnormalities are minimal, the dislocation is rasily
      reduced, and the treatment is simple. When diagnosis and treatment are delayed,
      the soft-tissue and bony abnormalities  become established and therapy becomes
      more complicated.

PMID- 1019060
TI  - Legg-Calve-Perthes disease.
AB  - Legg-Calve-Perthes disease affects children, mostly boys, in the age range of 3
      to 12 years. Severity and duration are quite variable. Catterall's classification
      of disease according to degree of femoral head involvement is of real prognostic
      value. Other factors of prognostic importance are loss of motion, metaphyseal
      cysts, subluxation and extrusion, and involvement of the epiphyseal plate, all of
      which are associated with poor results. Patients with Catterall group I
      involvement require no specific treatment as long as motion is normal. For
      patients under 6 years of age with group II involvement, specific efforts to
      contain the femoral head do not appear to bb indicated. In all other patients,
      maximum effort should be made to achieve containment of the femoral head and
      maintain full range of motion. Surgery has been used for reconstruction and as an
      alternative method of containment.

PMID- 1019061
TI  - Slipped capital femoral epiphysis: long-term results.

PMID- 1019062
TI  - Anteversion of the femur.

PMID- 1019063
TI  - Rotational problems of the lower extremity.
AB  - Rotational abnormalities in the lower extremities are common in the growing
      child, but they seldom represent any serious handicap in adult life. When
      confronted with such a problem, the physician should carefully rule out any
      underlying pathologic abnormality and should approach the problem in a step-wise
      fashion. The component parts of the lower extremity should be examined carefully
      and individually to assess their role in the rotational problem.  The usual
      causes of internal rotation problems, or toeing in, are metatarsus adductus,
      internal tibial torsion, and femoral anteversion. External rotation problems are
      infrequent and pose fewer problems. These include calcaneovalgus, external
      rotation of the tibia, and external rotatory contractures of the lower extremity.
      The natural history of these conditions favors improvement with time. However,
      some patients may require conservative treatment, such as stretching and splints.
      Rarely, a patient may require surgical intervention.

PMID- 1019064
TI  - Menstrual problems of the adolescent.
AB  - Pubertal changes occur at a constant rate and in a particular sequence;
      deviations are indicative of possible menstrual problems. Such problems include
      precocious puberty, amenorrhea, menstrual irregularity, cramps, and premenstrual
      tension. Of those patients with menstrual irregularity, 10% to 15% will have
      chronic conditions requiring lifelong treatment.

PMID- 1019065
TI  - Causes of sexual dysfunction.
AB  - Sexual problems can be classified as related to (1) desire, (2) arousal and
      penetration, (3) orgasm, and (4) subjective assessment. The usual cause of sexual
      dysfunction is psychosocial, eg, past conditioning, inadequate communication and
      cooperation between sexual partners. Possible organic or psychiatric causes
      should be ruled out, however.

PMID- 1019066
TI  - Vitamin preparations: proper use in medical practice.
AB  - The prescription of vitamin preparations as dietary supplements should be limited
      to specific instances of need and should be accompanied by appropriate measures
      to correct poor diets. Similarly, specific vitamins in therapeutic amounts should
      be prescribed only in the presence of vitamin deficiencies or increased
      requirements.

PMID- 1019067
TI  - The general internist: an academic viewpoint.
AB  - The general internist is more than a physician possessing the sum of knowledge of
      the medical subspecialities. He or she must have distinct personal attributes and
      management skills as well as the traditional diagnostic and treatment
      capabilities.

PMID- 1019068
TI  - Traumatic injuries: office treatment of eye injury. 1. Injury due to foreign
      materials.
AB  - Patients with eye injuries caused by foreign materials are often seen by the
      primary physician. The causative agents may be foreign objects, noxious liquids
      or vapors, ultraviolet irradiation, or contact lenses. Injuries caused by foreign
      bodies that do not penetrate the outer coats of the eye can be treated by the
      nonspecialist; the intraocular presence of an object requires prompt referral to
      an ophthalmologist. Ultraviolet light irradiation and contact lenses worn for a
      prolonged period cause a great deal of pain to the eye but injury is not serious
      and the eye heals well. Injury from chemicals may be moderate or severe; if pain
      and functional impairment persist after copious irrigation of the eye with
      sterile saline solution, the patient should be referred to an ophthalmologist.

PMID- 1019069
TI  - Community medicine. Triage-a new look at an old French concept.
AB  - Triage involves making judgments as to type and extent of injury. It is begun at
      the scene of any injury or whenever a patient enters into a health care system.
      Subsequently, each patient is reevaluated at different stages of care. In recent
      years a number of mathematical models have been developed to describe patients
      with multiple injuries, to evaluate emergency care, and to predict the outcome of
      trauma. While these grading indexes clearly are not flawless, they are helpful
      tools in determining priority of care.

PMID- 1019070
TI  - Straight back syndrome.

PMID- 1019071
TI  - Immunization practice: some important guidelines.
AB  - The right of patients (parents) to know, in detail, the risks inherent in
      immunization procedures is an important issue. There is legal precedent for
      holding a physician or drug manufacturer liable for hazards inherent in
      immunizing materials even if no negligence is involved.

PMID- 1019072
TI  - The spectrum of chronic lymphocytic leukemia.
AB  - The state of differentiation of the lymphocytes in chronic lymphocytic leukemia
      is a factor that appears to correlate with the presence and severity of clinical
      manifestations of the disease and with the incidence of complications. Among drug
      regimens proposed to date, the most efficacious in poorly differentiated disease
      appear to be the three- and four-drug combinations.

PMID- 1019073
TI  - Response of laying hens to a low salt diet.
AB  - Two experiments were conducted with commercial Leghorn-type hens in advance state
      of production (16 months of age) to determine response to a 16% protein, corn-soy
      diet with no added salt. There was an immediate and significant decline in feed
      consumption. Body weight decreased significantly. After 14 days, there were no
      ova in the rapidly maturing stage. The ovary may have been reduced in size but
      apparently was not regressed. Egg specific gravity was significantly reduced but
      egg weight was unaffected. Egg production dropped to 0% in 17-21 days. On the
      return of 0.25% salt to the diet, recovery as measured by production rate was
      initiated immediately with production reaching 79% in 16 days compared to a pre
      experimental production of 68%.

PMID- 1019074
TI  - Variable rachitogenic effects of grain and alleviation by extraction or
      supplementation with vitamin D, fat and antibiotics.
AB  - Three experiments were conducted using day-old broiler type chicks to determine
      the effect of different cereal grains on vitamin D3 utilization and to
      investigate the effects of rye, corn, wheat and triticale as the cereal grain
      component of the diets on the development of a rachitic condition in chicks. Rye
      was submitted to acid treatment and water extraction in an attempt to destroy or
      isolate the rachitogenic factor. Results showed that with chicks fed a diet
      containing 200 I.U. of vitamin D3 with corn as the grain, mineralization of their
      bones was normal. Growth and bone ash were depressed when rye replaced corn in
      the diet. These effects were partially reversed when either fat or procaine
      penicillin was added to the diet, and comppletely prevented with a high level of
      vitamin D3 (2,000 I.U./kg.). In another experiment, triticale depressed bone ash
      even though it did not affect body growth to the same extent as rye. Our results
      indicate that the factor responsible for the rachitogenic condition of rye-fed
      chicks can be removed by water extraction of this grain or partially destroyed by
      acid autoclaved treatment. A combination of acid autoclaved treatment and
      penicillin supplementation prevented the depression in bone ash.

PMID- 1019075
TI  - A cephalic influence on gastric motility upon seeing food in domestic turkeys
      (Melagris gallopavo), great-horned owls (Bubo virginianus) and red-tailed hawks
      (Buteo jamaicensis).
AB  - Strain gage transducers were permanently implanted on the muscular stomachs of 13
      turkeys, 3 great-horned owls and 2 red-tailed hawks to monitor gastric motility
      before, during and after eating. Following fasting, the sight of food resulted in
      significant increases in gastric contractile activity in all three species.
      Gastric motility further increased when the birds were allowed to eat. In
      raptors, however, a brief interruption in gastric motility occurred immediately
      after eating. This is apparently analogous to receptive relaxation which occurs
      in the stomach of mammals.

PMID- 1019076
TI  - The use of bile salts to improve absorption of tallow in chicks, one to three
      weeks of age.
AB  - Apparent fat absorption was 39.6 and 68.2% in chicks 4-7 and 14-19 days of age,
      respectively, fed purified-type diets with 8.2% tallow (TLW). Cholic acid (C.A.),
      chenodesoxycholic acid (Ch.A.) and taurocholate, sodium salt (T.A.) at .025 and
      .05% increased significantly the apparent absorption of fat by 8.4 percentage
      units in chicks 4-7 days of age, and as much as 10 percentage units in chicks 14
      19 days of age. No significant increase in metabolized energy of diets was
      detected. C.A. was fed to S.C.W.L. hens at graded levels up to .2% in corn-soy
      diets containing either 4 or 8% TLW or hydrogenated soybean oil. No improvement
      in fat absorption or M.E. was detected in these hens which absorbed 86-89% of the
      fat. The data indicate that bile salts appear to be effective in improving the
      absorption of saturated-type fats only in young chicks whose absorptive mechanism
      for fat is not fully developed.

PMID- 1019077
TI  - Fertility of frozen chicken semen after intravaginal and intrauterine
      inseminations using various concentrations and equilibration times of
      dimethylsulfoxide and a range of freezing and thawing rates.
AB  - The use of dimethyl sulfoxide (DMSO) as a cryoprotective agent for freezing
      chicken semen was examined with respect to intravaginal (I.V.) and
      intrauterine(I.U.) inseminations. Semen diluted in DMSO was subjected to various
      freeze rates, equilibration times and thawing rates. Various concentrations of
      DMSO were examined as was the effect of diluting DMSO with phosphate buffer and
      Lake's solution. There was no significant (p greater than 0.05) effect of rate of
      freeze (ranging from 1.3 degrees C to 7.2 degrees C. per min) on fertility.
      However, rapid thawing in an ice bath resulted in a longer (p less than 0.05)
      duration of fertility than thawing at 1 degree C. per min., but had no effect on
      percent fertility during duration or percent hens fertile. Equilibration time and
      concentration of DMSO had no significant (p greater than 0.05) effects on
      fertility. There was no interaction between insemination route and Lake's
      solution vs. phosphate buffer with respect to duration of fertility. It was
      concluded that intrauterine (I.U.) insemination resulted in superior fertility to
      intravaginal (I.V.) inseminations with semen frozen in DMSO.

PMID- 1019078
TI  - Calcium balance in the quail (Coturnix coturnix japonica). 1, Influence of sex
      and diethylstilbestrol.
AB  - Young adult male and laying female quail, fed with a diet containing 2.64% Ca and
      0.70% P, were used to study nutritive utilization, corporal calcium retention and
      endogenous excretion, calcemia, laying and properties of the egg (including the
      shell structure), mineralization of the femur bone, as well as the influence of
      diethylstilbestrol upon these parameters. The coefficient of nutritive
      utilization (C.N.U.) in the female was high and logically superior to that of the
      male, while the corporal retention was quite similar for both sexes. Most of the
      Ca absorbed (81.8%) and not excreted in urine, went to the egg and only 18.2%
      remained in the body. The diethylstilbestrol caused a big reduction of the C.N.U.
      in the female, but not in the male, parallel to an inhibition of laying, and an
      increase of corporal retention of used calcium. In both sexes the calcemia
      surprisingly increased, and the calcium level of the femur bone was higher, and
      even though the cortical osseous zone was slightly wider, the effect of treatment
      was noticeable, particularly in the medular tissue, which incremented in the
      female and appeared in the male. When quail were fed a calcium-restricted diet,
      the endogenous excretion of this mineral was small in the case of the female and
      significantly smaller in the male. This situation suppressed egg laying and
      resulted in a clearly decreased bone mineralization. The ingestion of
      diethylstilbestrol before feeding a diet poor in calcium provoked an increase of
      the endogenous excretion of calcium in both female and male quail.

PMID- 1019079
TI  - The responses of chicks to ammonium, calcium, magnesium, potassium and sodium
      sulphates and to ammonium and potassium carbonates.
AB  - The responses of chicks of 14 days of age to increasing levels of dietary anions
      and cations were investigated in two experiments. Major reductions in weight
      gains per chick and in gain:feed ratios were observed in chicks as levels of
      dietary sulphate, with ammonium or potassium cations, were increased from 0
      through 5 g. per 100 g. diet. Sodium sulphate had a similar but smaller effect.
      Calcium and magnesium sulphates  increased weight gains and gain:feed ratios at
      low levels of dietary inclusion. The relative effect of anion and cation were
      studied in the second experiment. Potassium carbonate  reduced weight gains  and
      gain:feed ratio to a greater degree than potassium sulphate; however the higher
      dietary levels of ammonium carbonate had little effect on chick growth responses
      in contrast to the major reductions obtained in  response to ammonium sulphate.
      There were no differences between responses of strains of chicks within
      experiments. None of the salts were lethal at the levels fed.

PMID- 1019080
TI  - Effect of DDE, DDT and calcium on the performance of adult Japanese quail
      (Coturnix coturnix japonica).
AB  - Two experiments were conducted to determine the effects of DDE, DDT and calcium
      on performance of quail. The quail received diets containing 0 or 100 p.p.m. of
      DDE for eight 28-day periods in Exp. 1 and 0, 100 or 300 p.p.m. of DDE or 100
      p.p.m of DDT for six periods in Exp. 2. Diets containing either 0.5 or 3% calcium
      were used with each pesticide level. No differences in egg shell thickness,
      cracked eggs, egg production, feed consumption, egg weights, female body weights,
      fertility or hatchability were obtained from DDE or DDT up to 100 p.p.m.  Three
      hundred p.p.m. of DDE did result in a decrease in female body weights and in
      fertility on the low calcium diet. Egg shell thickness, cracked eggs, egg
      production and hatchability were affected by the lower calcium level. Male body
      weights were adversely affected from 100 p.p.m. or more of DDE. Mortality
      increased as the level of DDE increased for females, while no effect was observed
      with DDT. Males appeared more sensitive to 100 p.p.m. of DDE in Exp. 1 and 300
      p.p.m of DDE and 100 p.p.m. of DDT in Exp. 2. Livability and growth of chicks
      from hens receiving rations containing DDE AND DDT were unaffected by maternal
      treatment. In summary, DDE and DDT were without effect on egg shell quality or
      most other reproductive factors, but DDE at 300 p.p.m. did exert a detrimental
      effect on adult body weights, fertility and mortality.

PMID- 1019081
TI  - Behavioral and physiological studies of seizures induced by systemic injection of
      metrazol in chickens.
AB  - The influence of systemically administered Metrazol on behavior,
      electroencephalogram and body temperature has been studied in young and adult
      chickens. Distinct convulsions were induced by 30--50 mg./kg. Metrazol
      administered intravenously in adults: they consisted of an initial excited state,
      a tonic convulsion accompanied with opisthotonos, and finally, convulsive
      movements. During recovery from these convulsions, three distinct behaviors were
      observed: violent peck-like movement, watchful state and finally panting
      behavior. All of the birds receiving higher intravenous doses (60--100 mg./kg.)
      exhibited vigorous convulsions immediately after injection and death occurred in
      100% of the birds receiving these doses. An intraperitoneal injection of 75--100
      mg./kg. Metrazol produced typical convulsions in young and adult chickens. At
      these doses, convulsions consisted of an initial excited state, a tonic
      convulsion accompanied with opisthotonos, and convulsive movements which involved
      clonic and tonic phases. The threshold for evoking typical convulsions with
      intraperitoneal injection ranges between 50 and 60 mg./kg. Metrazol in young
      chickens. The intravenous threshold doses for evoking high amplitude (1--2 mV.)
      in the EEG of adult chickens was 60 mg./kg. Metrazol. High intraperitoneal doses
      of Metrazol(75-100 mg./kg.) produced typical spikes with large amplitude which
      were synchronous in the two hemispheres in both young and adult chickens. There
      was a marked increase in body temperature within 10 minutes after injection in
      all cases of 50 mg./kg. intravenous dose: maximum increase (at 40 min.) was 1.5
      degrees C. as compared with controls, however, it decreased rapidly with panting
      behavior. The highest does (100 mg./kg.) produced a maximum increase in body
      temperature of 3 degrees C. Discussion of epileptic seizure susceptibility to
      Metrazol in aves, in the light of phylogenesis, is discussed.

PMID- 1019082
TI  - Body temperature and blood chemistry responses in broiler cockerels given a
      single intravenous injection of Na+ or Ca++ before an acute heating episode.
AB  - Eight-week-old broiler cockerels were injected intravenously with avian saline
      containing additional Na+ as NaCl or Ca++ as CaCl2. After the injections half of
      the chickens were heated at 45 degrees C. and the others were maintained at 24
      degrees C. Cloacal body temperatures were determined and blood samples were
      collected before heat exposure and at 30 minute intervals until the chickens had
      been heated for 120 minutes. Na+ did not affect body temperature of chickens in
      the 24 degrees C. environment, but Na+-treated chickens in the 45 degrees C.
      environment had significantly elevated body temperatures compared to the heated
      controls. Ca++ caused a significant decrease in body temperature of the non
      heated chickens, but it was without effect in heated chickens. Neither Na" nor
      Ca++ altered the responses of plasma glucose, cholesterol, and calcium during the
      heating episode. However, Ca++ caused a significant rise in plasma inorganic
      phosphate in non-heated chickens and prevented the rapid decline in the heated
      chickens. Na+ caused a significant fall in plasma inorganic phosphate in non
      heated chickens, but it did not alter the plasma phosphate response to acute heat
      stress. The present experimental resultn chickens in a moderate temperature
      environment, and suggests that Ca++ initially exerts a peripheral rather than a
      central effect in decreasing the body temperature.

PMID- 1019083
TI  - Thy hydrolysis of phytate phosphorus by chicks and laying hens.
AB  - The chromic oxide balance method was used to determine the amount of natural
      phytate phosphorus hydrolyzed by chicks and laying hens. Broiler chicks 4 and 9
      weeks old and Single Comb White Leghorn hens were fed diets containing corn as
      the only grain source or diets in which wheat replaced one half of the corn.
      Feces were collected twice daily during the 7-day test period. The phytate
      phosphorus recovered in the feces of the 4 and 9 week old chicks and the laying
      hens fed the diet containing corn was 100, 98, and 92%. When wheat replaced one
      half of the corn the recovery was 92, 87 and 87%. The phytase activity in wheat
      was minimal in vivo; whereas, in vitro tests indicated enzyme activity.

PMID- 1019084
TI  - Studies on the enteric absorption of selenium in the chick using localized
      coccidial infections.
AB  - Studies were conducted to determine the primary loci of gastrointestinal
      absorption of inorganic selenium in the chick using radiotracer techniques and
      Eimeria sp. infections of known site specificity for the gastrointestinal tract.
      Results showed that coccidial infections in the anterior regions of the small
      intestine reduced selenium absorption and potentiated selenium deficiency among
      chicks fed critical levels of the mineral. Absorption experiments showed that
      selenium absorption was greatest in the duodenum and anterior ileum, although
      selenium was bound at least transiently to tissues in the gizzard and crop. It is
      concluded from these experiments that dietary inorganic selenium is absorbed
      primarily in the duodenum and anterior ileum. Factors such as enteric disease
      which disrupt the integrity of the anterior intestinal mucosa can, therefore,
      reduce the absorption of selenium and other nutrients absorbed in that region,
      resulting in a potentiation of nutritional deficiencies.

PMID- 1019085
TI  - Effects of 1,3-butanediol and 1,2-propanediol on growth, blood metabolites, and
      liver glycogen broiler chickens.
AB  - Control diets, and diets containing 4% 1,3-butanediol (BD), 8% BD, 4% 1,2
      propanediol (PD) and 8% PD were offered ad libitum to broilers from 1 to 28 days
      of age. Body weight gain and feed intake were recorded, and plasma metabolites
      and liver glycogen were measured. When compared to the control diet, the
      synthetic compounds depressed (p less than 0.01) growth at the 4% level, but the
      effect was more pronounced (p less than 0.01) at the  8% level. The test
      compounds had no effect (p less than 0.05) on the efficiency of feed utilization.
      Four percent BD elevated (p less than 0.01) plasma beta-hydroxybutyrate and
      acetoacetate concentrations, and the ratio of beta-hydroxybutyrate to
      acetoacetate. The influence was more pronounced at the 8% level; PD did not
      affect (p greater than or equal to 0.05) ketone body concentrations. Neither BD,
      nor PD caused changes (p greater than or equal to) in plasma glucose, free fatty
      acids, cholesterol, or liver glycogen. Results are discussed with reference to
      feeding these compounds to monogastric and ruminant animals.

PMID- 1019086
TI  - Accumulation and depletion of dieldrin in visceral fatty tissue of broilers.
AB  - White rock chicks were fed a commercial crumbles ration with approximately 1.0
      p.p.m. of the active ingreient of technical grade dieldrin added to it. The
      treated feed was replaced by uncontaminated feed at various times from two to
      eight weeks of age. Equations were computed to describe the accumulation and
      depletion of the insecticide in visceral adipose tissue. Accumulations in females
      were described by polynomial equations with significant quadratic coefficients
      which indicated that the rate of accumulation leveled off between six and eight
      weeks. Accumulation rates in males were essentially linear through ten weeks.
      After removal of dieldrin from the feed, insecticide depletion from fat could be
      described in both sexes by equations for power curves. Replacement of
      contaminated feed with uncontaminated feed by two or three weeks of age resulted
      in concentrations at control or background levels by eight weeks of age.
      Replacement of contaminated feed with non-contaminated feed at ages later than
      three weeks did not bring concentrations below those acceptable as non-hazardous
      for human consumption.

PMID- 1019087
TI  - Studies on the daily protein and amino acid needs of broiler breeder hens.
AB  - Feeding trials were conducted with broiler breeder hens to determine optimum
      daily intake of protein for maximum performance. Pullets were grown to 24 weeks
      of age on limited feed intake to maintain the body weight within the limits
      suggested by the breeder. A controlled-feeding system was used during the laying
      period with step-wise increase in calorie intakes. In the first study corn
      soybean type diets were used to supply 14 to 22 grams of protein/day in 2 gram
      increments. In the second study daily protein intakes of 14.5 to 24 grams were
      compared. In addition, diets supplying 14.5 and 16 grams of protein daily were
      also fed with an additional 200 mg/day of lysine and methionine. The results of
      these studies suggest that the protein requirement of broiler breeder hens fed
      corn-soybean meal diets without supplemental amino acids is 20-22 grams per day.

PMID- 1019088
TI  - Lysine requirement of hens fed diets with corn as the major cereal grain.
AB  - Two experiments were conducted to determine the lysine requirement of laying
      hens. Corn was used as the cereal grain, and cottonseed meal, peanut meal, and
      corn gluten meal supplied supplemental protein. In Experiment 1 a daily lysine
      intake of 607 mg. per hen per day was adequate for maximum egg production and egg
      weight. In Experiment 2 basal diets were calculated to contain 2880 M.E. kcal/kg.
      or 3110 M.E. kcal/kg. The lysine requirement for the lower energy diet was 657
      mg. per hen per day and for the higher energy diet was 636 mg. per hen per day. A
      lysine requirement of 650 mg. per hen per day is recommended.

PMID- 1019089
TI  - Simplified hypophysectomy technique for young birds.
AB  - The present work introduces a modified oral approach to the pituitary gland of
      the immature bird with improved localization and visualization of the organ in
      situ. The hypophysectomy procedure is based on simplified instrumentation readily
      available or constructed with materials present in most, if not all,
      laboratories. The technique has the added advantage of minimal exsanguination,
      virtually no operative trauma, and allows for a rapid post operative animal
      recovery.

PMID- 1019090
TI  - Selection for increased semen yield in the turkey.
AB  - Selection was effective in greatly increasing semen yield in the turkey. After
      five generations of selection semen yield in the selected line was more than
      double that of the randombred control line from which the semen line was
      developed. The realized heritability of semen yield was .35 +/- .20. There was no
      consistent change in sperm concentration or frequency of bent sperm associated
      with the increased yield. Egg production was increased in the semen line. The
      increase occurred in the first generation of selection and was maintained
      throughout the remaining generations of selection. Body weight during the growing
      period exhibited an initial increase in the semen line but declined to randombred
      control levels in later generations. There was no consistent change in percent
      fertility, percent hatchability of fertile eggs or number of poults produced per
      hen which was associated with the genetic increases in semen yield.

PMID- 1019091
TI  - The arginine requirement of the 4-7 week old broiler.
AB  - Two floor pen studies were conducted to determine the minimum arginine level
      needed to support maximum weight gain and optimum feed conversion during the 4-7
      week period of growth for both males and females. Floor feather counts were used
      as an additional criteria for determining the arginine requirement. The basal
      diets were calculated to contain 0.74 and 0.80% arginine based on the analyzed
      values for corn, corn gluten meal, skimmilk and soybean meal. Regression
      equations were calculated from the data obtained for the males only. Based on the
      regression equations, the calculated requirement for maximum weight gain, optimum
      feed conversion, and floor feathers is 1.09, 1.10, and 1.13% arginine,
      respectively. When expressed as a function of energy, the requirements would be
      0.329, 0.332, and 0.341% arginine per megacalorie of metabolizable energy per kg.
      of diet, respectively. The differences in rate of gain data for the females were
      non-significant, indicating the requirement of the females to be less than the
      males. The female requirement, based on floor feathers, would appear to be 0.98%
      dietary arginine.

PMID- 1019092
TI  - Studies on the accessory reproductive organs in the drake.
AB  - The effects of the fluid from the ejaculatory groove region (EGR-fluid) on the
      survival and fertilizing ability of spermatozoa of the drake were examined. Semen
      was collected from the ductus deferens and divided into three parts; one remained
      undiluted (control 1) and other two were diluted with EGR-fluid and phosphate
      buffer (control 2) respectively. The survival of spermatozoa stored in the EGR
      fluid was similar to that of controls but many spermatozoa were deformed during
      storage, the rate of which reached 57% in the samples stored for 24 hours. The
      fertilizing ability of the fresh (unstored) spermatozoa was not adversely
      affected by the addition of EGR-fluid but a rather favourable effect of the fluid
      was recognized. In contrast, when the spermatozoa were stored in vitro, the EGR
      fluid exerted an adverse effect on the fertilizing ability of spermatozoa.

PMID- 1019093
TI  - Effect of selenium and mercury on gross morphology and histopathology of chick
      embryos.
AB  - Gross lesions of selenium toxicity in chick embryos included webbed, fused, and
      curled toes; cracked, crooked, and shortened beaks and gastroschisis. Mercury
      injection on day 3 of incubation caused leg defects but older embryos were much
      less susceptible. Histopathological studies showed that injection of selenium as
      selenite caused dissociation of hepatic cells, particularly around the central
      veins. Glomeruli of affected kidneys were enlarged, and in each glomerulus the
      lumen of the capillary tuft was dilated and the space of Bowman widened.
      Epithelial cells of the proximal convoluted tubules were detached from the
      basement membranes. Injection of mercury as chloride resulted in liver pathology
      in the late dead embryos which included dilated central veins and sinusoids. The
      cytoplasm of many hepatic cells was vacuolated. Foci of hemorrhages were observed
      in all liver lobes. In the kidneys, the renal corpuscles showed either shrinkage
      or enlargement. They seemed to be in the process of degeneration and
      disintegration. Sclerotic glomeruli were characterized by disappearance of
      Bowman's space and clumping of the glomerular tuft. Combined treatment with
      selenium and mercury resulted in liver pathology similar to that observed in
      mercury toxicity. The hepatic cell dissociation seen in selenium treated embryos
      was not observed following the combined treatment. In the kidneys the combined
      treatment resulted in typical lesions of both selenium and mercury toxicity.

PMID- 1019094
TI  - Stability of immune potency of tylosin 1-killed, broth-propagated Hemophilus
      gallinarum bacterin.
AB  - Immunizing potency of broth-propagated Hemophilus gallinarum (HG)bacterin was
      compared with tylosin and thimerosal treatment as the HG-inactivation agent and
      preservative. The immunizing potency of a tylosin-treated HG bacterin was as
      stable as a thimerosal-treated bacterin after 53 months storage at 2 to 5 degrees
      C.

PMID- 1019095
TI  - Effect of vasoligation on the reproductive organs of immature cockerels of the
      domestic fowl (Gallus domesticus).
AB  - Fifteen sexually immature, 12-week-old cockerels were unilaterally vasoligated.
      Eight of these were killed at 4 weeks post-ligation and the remaining 7 at 10
      weeks post-ligation. Granulomatous lesions in the ductus deferens were observed
      in 2 cockerels of the first and in 1 cockerel of the second group. Cysts showing
      intense granulomatous reactions were present in the epididymis in 1 cockerel of
      the first group and 4 cockerels of the second group. The seminiferous tubules
      were not seriously affected. The contralateral organs acted as controls and were
      grossly and histologically normal.

PMID- 1019096
TI  - Anticoccidial action of monensin in turkey poults.
AB  - Monensin was effective within the range 60-100 p.p.m. in control of coccidiosis
      in turkey poults in a series of laboratory experiments. Under conditions of heavy
      infections with Eimeria meleagrimitis and E. adenoides, 100 p.p.m. of monesin was
      significantly more effective than 60 p.p.m. in protecting weight gains. When
      light or moderate infections with E. meleagrimitis, E. adenoides and E.
      gallopavonis were used, there were no significant differences among monesin
      medicated treatments. In all instances the monensin-medicated treatments gained
      significantly more weight than noninfected, nonmedicated controls, when measured
      at 7 days post-inoculation. Similarly, oocyst, passage was reduced, feed
      conversion was protected and mortality was controlled in monensin-treated poults.

PMID- 1019097
TI  - Assessment of the quantity of biologically available phosphorus in yeast RNA and
      single-cell protein.
AB  - Two assays were conducted with chicks fed a phosphorus-deficient crystalline
      amino acid diet from day 8 to 17 posthatching to evaluate the phosphorus
      availability of purified torula yeast RNA and single-cell protein (Torula yeast).
      Tibia bone ash of the chicks was the criterion used in both assays, and
      regression analysis was used to evaluate bone ash as a function of phosphorus
      intake. A standard curve was established by feeding graded levels of KH2PO4 in
      each assay. Weight gain, tibia weight and tibia ash all responded to phosphorus
      supplementation whether provided by KH2PO4, RNA or single-cell protein. Weight of
      tibia ash provided the best linear fit when evaluated as a function of phosphorus
      intake. Availability in both assays estimated using the slope-ratio technique
      wherein milligrams of available phosphorus per gram of RNA or single-cell protein
      was calculated. In assay 1 the available phosphorus in RNA was found to be 93.2
      mg/. In assay 2 the available phorphorus in single-cell protein was found to be
      14.1 mg./g.

PMID- 1019098
TI  - Sexual maturity and persistency of lay in the Chukar partridge given stimulatory
      light at different ages.
AB  - In two separate trials, age at sexual maturity (lay of 1st egg) and total eggs
      laid in a 13-week production period were determined for the Chukar partridge
      given stimulatory light at 16, 18, 20, 22, 24, 26, 28 or 30 weeks. The best
      responses occurred with hens given stimulatory light when 26 weeks of age or
      older. More than 85 percent of these hens laid, and production ranged from 15 to
      25 eggs per hen. The youngest age at 1st egg was 161 days, required by one hen
      given stimulatory light at 16 weeks. Many hens given stimulatory light at 24
      weeks or younger failed to lay, and egg production was extremely poor in those
      that did lay. Based on our results, best egg production can be attained when
      birds are given stimulatory light at 28 weeks, allowed to lay for 13 weeks, then
      cycled to lay again when 50 weeks of age. Hens of superior laying ability can be
      detected in the first cycle of lay, thus reducing the time that would be required
      to identify these same birds if allowed to lay under natural daylight conditions.

PMID- 1019099
TI  - Legless--a lethal condition in the domestic fowl.
AB  - The abnormality resulting in legless condition which appeared in one pedigree
      mating in the R.I.R. stock is reported. The condition was lethal to the affected
      embryos between five and seven days of the incubation period. The matings carried
      out suggested that the condition was not hereditary but since only two males were
      raised from the original mating it cannot be stated with certainty.

PMID- 1019100
TI  - Persistence of semen quality during the reproductive period in two strains of
      turkeys differing in semen yield.
AB  - Semen yield, sperm concentration and frequency of bent sperm were measured during
      the ninth week following stimulatory lighting (in January) and correlated with
      similar measurements obtained 1-1/2 and 4-1/2 months later in the reproduction
      period for two strains of medium bodied turkeys differing in semen yield. These
      correlations, based on measurements made early in the reproductive period, were
      not large enough so that the male's subsequent performance could accurately be
      predicted. Strain differences were also apparent in correlation coefficients for
      semen yield. The correlation coefficients were larger for the strain having the
      smallest yeild. In general, the significant correlation coefficients between
      semen yield and sperm concentration were positive and those between semen yield
      and percent bent sperm and between sperm concentration and percent bent sperm
      were negative. However, the correlation coefficients tended to be low in
      magnitude.

PMID- 1019101
TI  - Light alterated changes in the embroynic age versus incubation age of White
      Leghorn embryos.
AB  - White Leghorn eggs were incubated in the dark or under two 20-Watt cool white
      flourescent tubes. The embryos were collected and staged according to somite
      number and other anatomical observations. Embryos from lighted eggs were
      significantly more advanced in embryonic age within 24 hours than embryos from
      the dark. By the end of 10 days no further acceleration of development by light
      was significant.

PMID- 1019102
TI  - The association of semen traits and fertility in the turkey.
AB  - There were no significant correlation coefficients between semen traits (yield,
      concentration and frequency of bent sperm) measured prior to the first
      insemination and fertility over a 12-week hatching period when the amount of
      semen inseminated per female was greater than the minimum (.025 cc.) usually
      recommended. Although there were some statistically significant correlations
      between semen measurements made later in the reproduction period and fertility
      for the entire period, they were very small ranging from -- .29 to +.20.

PMID- 1019103
TI  - Relationship of biotin to reproductive performance of Leghorn-type hens.
AB  - Five floor pens with 14 Leghorn-type breeder hens each, in their 4th month of
      production, and 2 males per pen were fed a practical-type breeder diet composed
      largely of soybean meal and milo supplemented with unidentified hatchability
      factor sources and adequate levels of vitamins and minerals. Five additional pens
      were fed an identical ration supplemented with biotin at a level of 550 mcg./kg.
      of diet. Treatment was for a period of 7 months. A 3% improvement in production
      was obtained by biotin (550 mcg./kg.) supplementation, which was found to be
      highly significant (P less than or equal to .005) by chi-square analysis. A
      slight improvement was noted for feed efficiency. Biotin supplementation had no
      effect on egg size or adult livability. Fertility and hatchability were both
      significantly improved by biotin supplementation. Fertility and hatchability
      differences were found to be highly significant by chi-square analyses. Increased
      hatchability was due to a decreased number of early dead, late dead, and pipped
      embryos that failed to hatch.

PMID- 1019104
TI  - [Effect of certain antibiotics of tetracycline series on the level of blood sugar
      and the role of insulin in the mechanism of its regulation].
AB  - Experiments on male rats showed enterally administered tetracycline and
      chlortetracycline to promote an elevation of the blood sugar level. These
      antibiotics administered once together with glucose retarded the normalization of
      the blood sugar concentration. After 7-day administration of tetracycline and
      chlortetracycline glucose load caused a stable hyperglycemia. Special experiments
      with depancreatization and insulin injection to the animals and also the
      intravenous injection of glucose and the antibiotic demonstrated that the changes
      in the blood sugar concentration under the effect of tetracycline were associated
      both with its inhibitory action on the absorbing function of the intestine and
      with the retarded glucose utilization in the tissues. Insulin injected
      intramuscularly eliminated the hyperglycemic effect caused by the antibiotics.

PMID- 1019105
TI  - [Main causes of death of patients with diabetes mellitus].
AB  - Among the causes of death in the patients with diabetes mellitus in Ukraine there
      prevailed cardiovascular disease (73.1 +/- 0.19%); malignant neoplasms ranked
      second (12.1 +/- 1.2%); tuberculosis constituted 1.6 +/- 1.2%, and all the rest
      of the diseases - 13.1 +/- +/- 1.2%, including coma - 0.5%. The frequency of
      death, particularly from cardiovascular diseases, is influenced by the patients'
      age, the severity and the duration of metabolic disturbances. The methods of
      treatment, particularly the saccharolytic sulphanilamide preparations, produce no
      effect on the death incidence.

PMID- 1019106
TI  - [Testicular feminization syndrome in children].
AB  - The paper is devoted to the clinical picture and the diagnosis of the syndrome of
      testicular feminization in children. Problems of the pathogenesis, treatment of
      this pathology and the choice of sex for their upbringing are given.

PMID- 1019107
TI  - [Morphology of the ovaries in congenital virilization of the external genitalia
      in persons with genetic and gonadal female sex].
AB  - A study was made of the resected ovarian tissue in 7 patients with congenital
      virilization of the external genitalia (CVEG). In patients with CVEG there
      occurred not very pronounced changes in the ovaries seen in diencephalic
      syndromes with the involvement of the ovaries into the pathological process
      (hypertrophy of the theca interna cells of the cystically changed follicles,
      hyperplasia of the intestinal tissue of the cortical layer with the
      transformation of individual cells into epithelioid, etc.). There were clinical
      signs indicating an acceleration of maturation of the diencephalic structures
      (some tendency to the acceleration of sexual development, and distinct signs of
      diencephalic pathology on the EEG). A conclusion was drawn that in the patients
      with CVEG the ovaries do not serve as the source of andronization of the
      organism. It is supposed that in these patients the source of hyperandronization
      existed at the period of formation of the external genitalia of the fetus and
      that the adrenal cortex of the fetus could serve as this source.

PMID- 1019108
TI  - [Effectiveness of clomiphene treatment in anovulatory conditions].
AB  - The paper presents, the data on the treatment of 74 patients with anovular
      conditions varying by the pathogenesis, with klomiphen. Three groups of patients
      were distinguished depending on the therapeutic efficacy: the 1st group with a
      complete clinical effect, the 2nd group with a partial clinical effect, and the
      3rd group - without any effect. In comparing the therapeutic efficacy with the
      data of gonadotropin examination it was revealed that the outcome of the therapy
      failed to depend on the initial LH and FSH level. However, there was revealed a
      reliable dependence of the therapeutic efficacy on the LH/FSH ratio: the nearer
      the LH/FSH ratio approached 1, the more effective was klomiphen therapy. Thus the
      LH/FSH ratio could be regarded as the criterion of choice of the patients for the
      klomiphen therapy, and could also be used for the prognostication of the results
      of treatment.

PMID- 1019109
TI  - [Clinico-electroencephalographic study of familial (genetic) forms of nanism].
AB  - Genetic nanism is a widespread phenomenon. Only familial forms constituted 22.8%
      of the cases of hypophysial and cerebral nanism. A total of 32 patients belonging
      to 15 families with repeated cases of the disease were examined clinically and
      electroencephalographically. In genetic hypophysial nanism clinical peculiarities
      of the disease and the EEG indices were similar within the limits of the same
      family and showed distinct differences in the patients belonging to different
      families. The differences are determined chiefly by the level of sex maturation.
      The EEG in genetic hypophysial nanism was identical to that in the total group of
      patients with the hypophysial nanism without any organic cerebral pathology. The
      EEG of the sexually immature patients suffering from nanism was characterized by
      the immaturity features both in the prepubertal period and in the course of the
      whole following life, whereas in the patients with a spontaneous sexual
      development the EEG corresponded to the age criteria at any age. The EEG
      examination of the patients with hypophysial nanism at the prepubertal period
      permits to prognosticate their subsequent sexual development.

PMID- 1019110
TI  - [Pachydermoperiostosis (certain problems of clinical course and differential
      diagnosis)].

PMID- 1019111
TI  - [Use of miscleron in diabetes insipidus].

PMID- 1019112
TI  - [Multiple adenoma of the parathyroid glands localized in the mediastinum].

PMID- 1019113
TI  - [Role of the pituitary gland in calcium and magnesium metabolism in dogs and
      rats].
AB  - Epiphysectomy in dogs and rats was accompanied by a reduction of urinary
      excretion of calcium and magnesium, by an increase in the magnesium concentration
      in the blood plasma of dogs. Administration of epiphysial extracts induced an
      increase of diuresis in dogs on account of a greater rate of glomerular
      filtration and a fall of the tubular water reabsorption. Calcium and magnesium
      urinary excretion increased in dogs and rats as well; this was due both to an
      increase of their ultrafiltration and a reduction of reabsorption in the renal
      tubules. Consequently, the epiphysis took part in the regulation of metabolism of
      bivalent cations.

PMID- 1019114
TI  - [Distribution of mineralocorticoid receptors in the kidney cells of rats with
      different levels of aldosterone in their bodies].
AB  - A metabolic method was applied to the study of the distribution of
      mineralocorticoid receptors in the kidney cells of rats at various aldosterone
      levels in the organism. A great number of binding sites of aldosterone in the
      cytoplasm and a low aldosterone-H3 binding by the nuclei of kidney cells was
      revealed in adrenalectomized rats, as well as in the animals kept under
      conditions of sodium load, when endogenous aldosterone was absent in the
      organism. A reduction of the number of binding sites in the cytoplasm and an
      increase of aldosterone-H3 binding in the nuclei was noted in the animals with a
      high content of the given hormone in the organism (sodium deficiency in food or
      aldosterone administration to the adrenalectomized animals). The difference in
      the hormone binding by the nuclei of the kidney cells of rats kept under
      conditions of sodium loading or deficiency corresponded to an even greater
      difference in the aldosterone binding by the chromatin proteins of such nuclei.
      It is supposed that an increased aldosterone concentration in the organism
      intensified the change from the cytoplasm and the accumulation of specific
      aldosterone-receptor complexes in the nuclei.

PMID- 1019115
TI  - [Certain characteristics of blood sugar in women aged 16-29 years according to
      glucose tolerance test].
AB  - Glucose tolerance test was conducted in 370 women aged from 16 to 29 years.
      Adiposity proved to be accompanied by a significant accretion of the glycemia
      level on fasting stomach, and 1 and 2 hours after glucose load, with the increase
      in the excess of weight not over the normal level. Glycemia level on fasting
      stomach failed to differ significantly in persons with an inadequate weight from
      such in persons with a normal weight. In the group with a decreased weight there
      was a significant blood glucose elevation 1 and 2 hours after the glucose load.
      Genesis of the glycemia increase differed in the groups with eleveated and
      reduced body weight. There was found no significant difference in the
      distribution of 16-29-year-old women by glucose tolerance depending on the excess
      of body weight.

PMID- 1019116
TI  - [Process of bile formation and bile composition in albino rats in acute adrenal
      cortex insufficiency and adrenal gland autologous transplantation].
AB  - Experiments were conducted on 84 male albino rats. A study was made of the state
      of the bile forming process 7, 14 and 30 days after bilateral adrenalectomy and
      adrenal gland autotransplantation. Investigations carried out showed inhibition
      of the bile formation with the corresponding changes in the chemical composition
      of bile to occur both in adrenalectomized animals and the rats with adrenal
      autotransplantation; in the second case, however, these changes were less
      pronounced. A gradual suppression of the intensity of bile production, cholate
      formation, bilirubin- and cholesterol secretion occurred in the adrenalectomized
      rats, whereas in the animals a significant shift in the direction of restoration
      took place as soon as in 7 days after autotransplantation. The first to become
      restored is the cholesterin secretory function in the liver, then the intensity
      of the cholate formation, particularly the glycocholic and desoxycholic acids,
      and bilirubin secretion. The intensity of bile secretion, as well as the sum
      total content of cholates in the bile, chiefly on account of taurocholic acid,
      failed to reach the initial level even by the 30th day after the adrenal gland
      autotransplantation.

PMID- 1019117
TI  - [Role of androgens in the effect of hydrocortisone and insulin on the ribonucleic
      acid synthesis in the cell nuclei and cytoplasm of the rat liver].

PMID- 1019118
TI  - [Evaluation of the quality and effectiveness of BCG revaccination in adults].

PMID- 1019119
TI  - [Sensitivity of school-children to tuberculin according to Mantoux test with 2TU
      PPD-L].

PMID- 1019120
TI  - [Hyperergic reactions to Mantoux test with 2TU PPD-L in mass screening of
      children and adolescents for tuberculosis].

PMID- 1019121
TI  - [Present-day state and perspectives of chemotherapy of tuberculosis].

PMID- 1019122
TI  - [Effectiveness of chemotherapy and short-term pneumoperitoneum in the treatment
      of destructive pulmonary tuberculosis].

PMID- 1019123
TI  - [Current state of tuberculosis control and the tasks of phthisiologists in the
      10th Five-Year Plan].

PMID- 1019124
TI  - [Comparative evaluation of different regimens of chemotherapy of pulmonary
      tuberculosis in middle-aged and old patients].

PMID- 1019125
TI  - [Bronchofibroscopy in tuberculosis and other lung diseases (methods, indications,
      contraindications)].

PMID- 1019126
TI  - [X-ray diagnosis of aftereffects and reactivation of primary tuberculosis
      complicated by bronchostenotic syndrome of the middle (lingual) lobe in adults].

PMID- 1019127
TI  - [Characteristics of metabolic disorders in chronic destructive pulmonary
      tuberculosis after treatment with rifampicin and ethambutol].

PMID- 1019128
TI  - [Study of protein spectrum of blood serum in pulmonary tuberculosis by the method
      of disc electrophoresis in polyacrylamide gel].

PMID- 1019129
TI  - [Lactate dehydrogenase isoenzymes of blood serum in pulmonary tuberculosis].

PMID- 1019130
TI  - [Blast transformation of lymphocytes as a criterion of the effectiveness of
      treatment of pulmonary tuberculosis].

PMID- 1019131
TI  - [Current problems of pathogenesis and clinical course of aspergillosis].

PMID- 1019132
TI  - [Sarcoidosis: Histological criteria and formulation of the theory of its probable
      pathomorphism].

PMID- 1019133
TI  - [Clinical course of viral hepatitis in pulmonary tuberculosis].

PMID- 1019134
TI  - [Tuberculosis of the abdominal organs].

PMID- 1019135
TI  - [Early detection of pulmonary tuberculosis after gastrectomy for peptic ulcer].

PMID- 1019136
TI  - The management of children with chronic disease.

PMID- 1019137
TI  - The medical care of children in developed countries.

PMID- 1019138
TI  - Sterility and fertility.

PMID- 1019139
TI  - Microvascular surgery.

PMID- 1019140
TI  - Vitamin A inhibition of murine melanoma.

PMID- 1019141
TI  - Haloperidol: retrospect and prospect.

PMID- 1019142
TI  - Haloperidol update: 1975.

PMID- 1019143
TI  - The rapid control of the acute patient by haloperidol.

PMID- 1019144
TI  - Efficient management of the acute psychotic patient: stabilization and
      maintenance with haloperidol.

PMID- 1019145
TI  - Adequate individualized dosages (AID) in perspective.

PMID- 1019146
TI  - Individual variability in response to haloperidol.

PMID- 1019147
TI  - Effect of gemfibrozil in vitro on fat-mobilizing lipolysis in human adipose
      tissue.
AB  - Fat-mobilizing lipolysis was studied in rat and human adipose tissue during
      incubation in vitro by following the release of glycerol into the incubation
      medium. Gemfibrozil as well as clofibrate consistently and readily inhibited
      basal as well as noradrenaline-stimulated fat-mobilizing lipolysis in rat fat.
      With human adipose tissue no effect was observed with gemfibrozil and clofibrate
      on basal lipolysis. This may be due to the comparatively low rate of the
      nonstimulated fat-mobilizing lipolysis in human tissue incubated in vitro. When
      lipolysis was stimulated with noradrenaline as well as isoprenaline, however,
      both gemfibrozil and clofibrate significantly reduced the fat-mobilizing
      lipolysis. This inhibition of lipolysis was however not observed in all studies.
      When lipolysis had been stimulated with theophylline, no inhibition of lipolysis
      was obtained with either compound. The possibility that reduced fat-mobilizing
      lipolysis in adipose tissue may cause a lowering of plasma triglycerides by
      reducing the flow of FFA to the liver is discussed in some detail. It is also
      suggested that inhibition of lipolysis may be accompanied by increased activity
      of lipoprotein lipase as well as an increase in the FIAT process. However, the
      pharmacological implication of the above-mentioned findings, particularly for
      gemfibrozil, must await further studies, as fairly large doses, around 1 mg/ml of
      incubation medium, were needed to obtain inhibition of fat-mobilizing lipolysis.

PMID- 1019148
TI  - Effect of gemfibrozil on lipolysis in dogs in vivo.

PMID- 1019149
TI  - Effect of gemfibrozil upon platelet function and blood coagulation. Preliminary
      report.

PMID- 1019150
TI  - Preliminary observations on the effect of gemfibrozil on the excretion of faecal
      bile acids.

PMID- 1019151
TI  - Gemfibrozil: a new lipid lowering agent. Open forum.

PMID- 1019152
TI  - Structure/activity relationship of gemfibrozil (CI-719) and related compounds.

PMID- 1019153
TI  - Binding to plasma lipoproteins of chlorophenoxyisobutyric, tibric and nicotinic
      acids and their esters.

PMID- 1019154
TI  - Extrinsic factors affecting the response to gemfibrozil.

PMID- 1019155
TI  - Gemfibrozil in a group of diabetics.
AB  - A group of 14 diabetic patients was treated with gemfibrozil during a variable
      length of time ranging from nine to 23 weeks in order to establish if a lowering
      effect on the cholesterol and triglyceride levels could be achieved, as it had
      been in the case of another group of non-diabetic patients. The present results
      showed that: (1) The drug is remarkably well tolerated. (2) With doses ranging
      between 400 and 800 mg per day the magnitude of the effect of the drug was less
      than that observed in our previous trial with non-diabetic subjects. The effect
      upon triglycerides seemed to be reduced more than that upon cholesterol when
      compared with results in higher-dose studies. (3) In this group of diabetic
      patients (3 insulin dependent, 11 maturity-onset type) control of the diabetic
      condition was never impaired and appeared in some cases to be slightly improved
      by gemfibrozil. (4) There was no evidence of undesirable interaction with any of
      the anti-diabetic drugs used.

PMID- 1019156
TI  - The evaluation of lipoprotein changes during gemfibrozil treatment.
AB  - During treatment with gemfibrozil, 1200 mg daily, total serum triglyceride levels
      were reduced in 7 of the 11 patients, owing chiefly to a fall in VLDL
      triglyceride levels. Total serum cholesterol responded variably, falling in a
      majority of patients with hypercholesterolaemia. High density lipoprotein
      cholesterol rose during treatment in patients who had either
      hypertriglyceridaemia or hypercholesterolaemia.

PMID- 1019157
TI  - Hyperlipidaemia in Scotland and the role of drug treatment.

PMID- 1019158
TI  - Summary of present data from a clinical trial of CI-719.

PMID- 1019159
TI  - The effect of CI-719 on lipolysis in rat adipose tissue.

PMID- 1019160
TI  - The use of saralasin to evaluate the function of the brain renin-angiotensin
      system.
AB  - The demonstration that the components required for the generation of angiotensin
      II are present in the brain has led to the proposal that there is a brain renin
      angiotensin system. To test this hypothesis, experiments were performed to
      determine if biologically active amounts of angiotensin II are formed when renin
      is injected into the cerebral ventricles. The effects of central administration
      of agents known to block the peripheral renin-angiotensin system were also
      investigated. It was shown that intraventricular renin increased water intake,
      blood pressure and ADH secretion and that these effects were blocked by
      saralasin. These findings indicated an interaction between injected renin, brain
      angiotensinogen and converting enzyme, resulting in the formation of angiotensin
      II in physiologically active concentrations. However, these experiments did not
      demonstrate a role for endogenous brain renin activity. Central administration of
      saralasin in normal animals did not decrease water intake, blood pressure or ADH
      secretion. These studies thus failed to demonstrate a physiological role for the
      proposed brain renin-angiotensin system in controlling water balance and blood
      pressure.

PMID- 1019161
TI  - Angiotensin II blockade in normal man and patients with essential hypertension.
      Blood pressure effects depending on renin and sodium balance.
AB  - 1) Saralasin was administered to 9 normotensive volunteers and 13 patients with
      essential hypertension after sodium depletion and sodium repletion. 2) In
      standing normotensive volunteers, angiotensin II inhibition induced significant
      hypotension if previously a cumulative sodium loss of at least 160-200 mEq had
      been induced. 3) In patients with essential hypertension, saralasin infusion
      induced either blood pressure reduction, no change or even significant blood
      pressure increase, depending on the prevailing state of sodium balance. 4)
      Following vigorous and prolonged sodium depletion induced by low sodium diet,
      with chlorthalidone and spironolactone, blood pressure became renin-dependent
      even in those patients who initially had exhibited a hypertensive response to
      saralasin, suggesting that under appropriate conditions, renin can play an active
      pressure role in all patients with essential hypertension. 5) Saralasin
      administration to patients with essential hypertension may not only be useful for
      recognizing renin dependency but may also, via the slight intrinsic agonistic
      effect of the compound, permit identification of overactivity of the sodium
      factor.

PMID- 1019162
TI  - The role of renin in the control of blood pressure in normotensive man.
AB  - In order to study the  role of renin in regulating blood pressure in normotensive
      states, saralasin (P113) was infused into normal subjects and patients with
      cirrhosis of the liver and ascites. In normal subjects on a normal sodium intake,
      P113 infusion had no effect on blood pressure. Only after the combined stress of
      a low sodium diet and the upright position did P113 lower the blood pressure. In
      two of the six cirrhotic patients, P113 caused a significant decrease in BP in
      the supine position. There was no consistent effect of the P113 infusion on
      plasma aldosterone or plasma renin activity in the normal or cirrhotic subjects.

PMID- 1019163
TI  - Changes of blood pressure, plasma renin activity and plasma aldosterone
      concentration following the infusion of Sar1-Ile8-angiotensin II in hypertensive,
      fluid and electrolyte disorders.
AB  - 1-Sarcosine, 8-isoleucine angiotensin II (Sar1-Ile8-AII) was infused
      intravenously in 5 normal volunteers and 66 subjects with various hypertensive,
      fluid and electrolyte disorders. Changes of blood pressure (BP), plasma renin
      activity (PRA) and plasma aldosterone concentration (PAC) were studied. In normal
      subjects, Sar1-Ile-AII showed pressor (agonistic) activity, which was related to
      both dosage and sodium intake. Hyporeninaemic hypertensive subjects (pirmary
      aldosteronism) showed pressor responses to a smaller dose of this compound than
      the dose employed in normal subjects. Hyporeninaemic hypertensive subjects and
      normal volunteers after 3 days of high sodium intake showed significant
      elevations of BP and PAC and reduction of PRA. Changes of BP, PAC and PRA in
      normoreninaemic subjects including those with Bartter's syndrome, renal tubular
      acidosis or liver cirrhosis with ascites showed reduction of BP and PAC and
      elevation of PRA. The results indicate that the compound has both agonistic and
      antagonistic activities for blood pressure; which of these is obtained apparently
      depends upon endogenous angiotensin II levels, as well as the dosage employed.
      The results in subjects with high and low PRA suggest that the compound has
      antagonist and agonist actions at 3 sites of angiotensin II action, i.e.
      peripheral vascular bed, renin release mechanism from juxta-glomerular apparatus
      and the zona glomerulosa of the adrenals.

PMID- 1019164
TI  - Angiotensin II blockade in hypertensive dialysis patients.
AB  - Five hypertensive haemodialysis patients have been infused with saralisin. The
      infusion appears to be a simple diagnostic test separating patients into two
      groups. First, there are those whose blood pressure does not fall with saralasin
      pre-dialysis, but does fall with weight removal during dialysis; the blood
      pressure in these patients can be controlled by a reduction in pre-dialysis
      weight. Second, there are those whose blood pressure does fall with saralasin
      either pre- or post-dialysis; their arterial pressure does not fall with weight
      removal, but can be controlled by anti-hypertensive drugs. In two of the patients
      who responded to saralasin, the mechanism of the high blood pressure appeared to
      change from volume dependency, partial or complete, with suppressed renin
      release, to angiotensin dependency, partial or complete, as weight was removed
      during dialysis. These patients illustrate the importance of the interaction
      between volume and the level of angiotensin II in the maintenance of
      hypertension.

PMID- 1019165
TI  - The use of saralasin in the recognition of angiotensinogenic hypertension.
AB  - Specific antagonists of angiotensin II (AII) such as saralasin might
      theoretically be of great value in the recognition of angiotensinogenic
      hypertension. Evidence is presented to show the importance of overcoming any
      existing sodium overload and of administering saralasin first in small and then
      in larger amounts by infusion (or injection). When this was done in 600
      hypertensive patients, 62 showed a fall in blood pressure of more than 10/8 mm
      Hg. Further tests in 50 of these subjects indicated that the fall in blood
      pressure was associated with high peripheral levels of plasma renin activity
      (PRA) and/or abnormal renal vein PRA ratios in 94%. The procedure rarely failed
      to detect even mild forms of angiotensinogenic hypertension. In 62 patients found
      to have angiotensinogenic hypertension, the responsible lesions included
      unilateral renal arterial stenosis with good contralateral renal function (29%),
      bilateral renal disease (21%), Cushing's syndrome (6%), small vessel disease or
      specific excess of renin production - without other detectable renal disease -
      (31%) and incompletely evaluated disorders (13%). Saralasin has been of great
      value in simply and reliably demonstrating the presence or absence of an
      angiotensinogenic component in a large group of hypertensive patients.

PMID- 1019166
TI  - The effects of the angiotensin II antagonist saralasin on blood pressure and
      plasma aldosterone in man in relation to the prevailing plasma angiotensin II
      concentration.
AB  - The effect of saralasin in lowering blood pressure and plasma aldosterone
      concentration in normal subjects, both sodium-replete and sodium-deplete, and in
      patients with various forms of hypertension, is closely related to the basal
      plasma angiotensin II concentration. These findings confirm and extend earlier
      studies of angiotensin II/arterial pressure and angiotensin II/aldosterone dose
      response curves. They also emphasize the importance of the renin-angiotensin
      system in the control of aldosterone in sodium depletion and in renal
      hypertension.

PMID- 1019167
TI  - Haemodynamic effects of Sar1-Ala8-angiotensin II in patients with renovascular
      hypertension.
AB  - Sar1-Ala8-angiotensin II was infused intravenously (10 mug/kg/min) in 14 patients
      with renovascular hypertension, including 11 with renal artery stenosis. Brachial
      artery pressure and heart rate remained unchanged in six patients who were on a
      daily sodium intake of 130 mEq. In 12 tests performed after sodium depletion, the
      decrease in mean arterial pressure ranged from 13 to 76 mm Hg and showed a
      significant correlation with the plasma renin concentration prevailing
      immediately before the infusion of the drug (r = 0.81; p less than 0.001). The
      hypotensive response was due to a drop in total peripheral resistance. Heart rate
      and cardiac output showed slight increases 10 min after the start of saralasin
      infusion.

PMID- 1019168
TI  - Comparative studies of the humoral and arterial pressure responses to Sar1-Ala8-,
      Sar1-Ile8 and Sar1-Thr8-angiotensin II in the trained unanaesthetized dog.
AB  - The humoral and arterial blood pressure responses to Sar1-Ala8-, Sar1-Ile8- and
      Sar1-Thr8-angiotensin II were studied in sodium-depleted, trained,
      unanaesthetized dogs. Of the three angiotensin antagonists, Sar1-Thr8-angiotensin
      II appeared to be the best suited for clinical use. In the smallest amount that
      was found to be effective in reducing arterial pressure, it was devoid of agonist
      activity. Also, in marked contrast to Sar1-Ala8- and Sar1-Ile8-angiotensin II,
      Sar1-Thr8-angiotensin II was not shown to stimulate either catecholamine or
      aldosterone secretion.

PMID- 1019169
TI  - Stimulating effects of angiotensin I, angiotensin II and des-Asp1-angiotensin II
      on steroid production in vitro and its inhibition by Sar1-Ala8-angiotensin II.
AB  - Two of the agents known to block the renin-angiotensin-aldosterone system, namely
      Sar1-Ala8-angiotensin II and the nonapeptide SQ 20881, have been used to clarify
      the role of angiotensin II (AII) and its cogeners upon the steroidogenesis in
      isolated fasciculata cells from bovine adrenal tissue. It could be concluded
      that: (1) des-Asp1-angiotensin II is as active as AII on steroidogenesis from
      bovine fasciculata cells; (2) angiotensin I, although less potent, stimulates
      steroid production without being converted to AII or des-Asp1-AII, and (3) Sar1
      Ala8-AII inhibits all three peptides in a competitive manner. The presence of a
      common receptor for all these three peptides is suggested.

PMID- 1019170
TI  - Effect of adrenal arterial infusion of saralasin (P113) on aldosterone secretion.
AB  - To test the role of the renin/angiotensin system in aldosterone regulation, Sar1
      Ala8-angiotensin II (P113) was infused into the arterial blood supply of
      transplanted adrenal glands in conscious sheep. Effects on the aldosterone
      response to infused angiotensin II and III in sodium replete sheep were compared
      with effects in sodium deficiency. Adrenal arterial infusion of P113 up to 1,000
      mug/h for 1-2h did not consistently alter the high aldosterone secretion rates of
      sodium-deficient sheep. However, infusion of P113 at 10 mug/h or more abolished
      aldosterone responses to angiotensin II infusion that caused high physiological
      blood levels of angiotensin II. These results are against the proposal of a
      primary proportional causal relationship between blood angiotensin II
      concentration and aldosterone secretion rate in sodium deficiency. They are also
      against the possibility that such a primary role is played by blood-borne
      angiotensin III.

PMID- 1019171
TI  - Effects of saralasin on renal function of the rat.
AB  - In the isolated perfused rat kidney, saralasin inhibits the vasoconstrictor
      effect of angiotensin II in a dose-dependent manner. At high infusion rates
      saralasin, by itself, increases renal vascular resistance and supresses renin
      release. Such an agonistic effect is not observed in the presence of high
      concentrations of angiotensin II. In acute renal failure induced by glycerol,
      saralasin has a beneficial effect on urine volume, solute excretion and plasma
      urea concentration only when it is administered together with an adequate volume
      of rat serum.

PMID- 1019172
TI  - Effects of angiotensin antagonists in various forms of experimental arterial
      hypertension.
AB  - The dependence of renal hypertension on increased levels of angiotensin II was
      investigated in conscious dogs at various stages of hypertension of four
      different types. Two of the most potent angiotensin inhibitors, Sar1-Ile8- and
      Sar1-Thr8-angiotensin II, were infused separately in various doses and at
      different times throughout the evolution of renal hypertension. The results of
      these experiments are consistent with the view that the renin-angiotensin system
      may participate in the acute and malignant phases of renal hypertension; they do
      not provide evidence for its participation when hypertension enters the chronic
      phase.

PMID- 1019173
TI  - Sterilization of barbiturates by gamma-irradiation.

PMID- 1019174
TI  - [Spectroscopic study of N-(2-diethylaminoethyl)-and N-[(1- ethyl-2
      pyrrolidyl)methyl]benzamide substituents].

PMID- 1019175
TI  - Pharmacokinetics of sulfadiazine upon different routes of administration in the
      rabbit.

PMID- 1019176
TI  - The effect of molecular weight on the properties of films prepared from
      hydroxypropyl methylcellulose.

PMID- 1019177
TI  - [Pharmacokinetic study of oral vincamine].

PMID- 1019178
TI  - The interaction of some N-phenylanthranilic acid derivatives with cyclodextrins
      in phosphate buffers.

PMID- 1019179
TI  - [Formulation of tablets and bioavailability: a biologic method of evaluation].

PMID- 1019180
TI  - Effects of d- and l-amphetamine on dorsal and ventral hypothalamic self
      stimulation in three inbred strains of mice.
AB  - The effects of intraperitoneal injections of increasing doses of d- and l
      amphetamine on self-stimulation behaviour in dorsal and ventral hypothalamic
      areas, were studied in BALB/c Orl., DBA/2 Orl, and C57BL/6 Orl inbred mice. Both
      isomers improved and disrupted self-stimulation as a function of the doses
      injected. However, the improvements obtained with d-amphetamine were higher than
      those obtained with 1-amphetamine. In contrast the 1 isomer generally provoked
      the highest disruptions. In addition, the three strains presented various
      sensitivities to d-amphetamine, which improved self-stimulation first in BALB/c
      (0.25 and 0.50 mg/kg), then in DBA/2 (0.50 and 1.0 mg/kg) and finally in C57BL/6
      (2.0, 4.0 and 8.0 mg/kg). The dorsal hypothalamic self-stimulation system
      presented a greater sensitivity to d-amphetamine than the ventral system; while
      the two reward systems reacted identically to 1-amphetamine.  The differential
      effects observed are set into relationship with neurochemical data concerning the
      central catecholaminergic mechanisms.

PMID- 1019181
TI  - Effects of selective forebrain depletions of norepinephrine and serotonin on the
      activity and food intake effects of amphetamine and fenfluramine.
AB  - Selective forebrain depletions of either norepinephrine or serotonin were
      produced in separate groups of rats by placement of lesions in the brainstem
      noradrenergic area and in the dorsal and median raphe nuclei respectively. Rats
      with norepinephrine depleting lesions exhibited an attenuation relative to intact
      animals of both the anorexic and locomotor stimulatory effects of amphetamine. In
      contrast, depletion of serotonin by the raphe lesion enhanced the locomotor
      stimulation induced by amphetamine but did not affect the anorexic efficacy of
      amphetamine. Neither brain lesion, however, reliably altered the animals'
      response to either the anorexic or activity effects of fenfluramine.

PMID- 1019182
TI  - Effect of magnesium deficiency on nonspecific excitability level (NEL) and
      audiogenic seizure susceptibility.
AB  - Magnesium deficiency in weanling rats caused an increase in NEL and in audiogenic
      seizure susceptibility. These behavioral effects were apparent after eight days
      of magnesium restriction and could be reversed by dietary rehabilitation. Serum
      magnesium declined rapidly from 1.87 +/- 0.10 mEq/L to 0.91 +/- 0.24 mEq/L in two
      days. Cerebrospinal fluid (CSF) magnesium decreased gradually from 1.86 mEq/L,
      becoming significantly lower (1.44 +/- 0.23 mEq/L) after eight days. When
      deficient rats were injected IP with MgCl2, raising the serum magnesium
      concentration to 6.6 mEq/L, NEL decreased to normal while audiogenic seizure
      susceptibility remained. Both NEL and audiogenic seizure susceptibility in rats
      reflect central nervous system magnesium concentration, except when serum
      magnesium concentration is very high. Very high serum  magnesium concentration
      lowers NEL but does not reduce audiogenic seizure susceptibility if CSF magnesium
      is low.

PMID- 1019183
TI  - Effects of pentobarbital on punished behavior at different shock intensities.
AB  - Key-pecking by two pigeons was maintained initially under a schedule where the
      first response after five minutes had elapsed produced food. When every 50th
      response produced shock, responding was suppressed (punishment). Although rates
      and patterns of punished responding remained comparable when the shock intensity
      was reduced by half, pentobarbital produced much greater increases in both
      overall and local rates of responding at the lower shock intensity. Pentobarbital
      also produced larger increases in the low rates of responding immedicately
      following shock when the lower intensity shock was in effect.

PMID- 1019184
TI  - Effects of lithium chloride on sleep patterns in the rat.
AB  - Continuous EEG recordings were performed in rats both  after saline injections
      (control days) and after LiCl treatments. LiCl administration was always followed
      by an initial period of general distress and sleep inhibition during 2 to 3 hr
      after low toxic doses (1.5 mEq/kg) and a much more longer period (10 hr) after
      high toxic doses (3 mEq/kg). Once this state was overcome, the pharmacological
      effect of lithimia seems to potentiate sleep and particularly paradoxical sleep
      (PS). It appears that this potentiation of PS occurs once lithimia reaches levels
      used in human therapeutics.

PMID- 1019185
TI  - Effects of monosodium glutamate on somatic development, obesity and activity in
      the mouse.
AB  - Neonatal mice 1 and 5 days of age and older mice 25 days of age were injected
      with an increasing dose of monosodium glutamate (MSG) for a ten-day period and
      observed for at least 150 days. Both male and female animals in the 1- and 5-day
      age group treated with MSG showed large increases in weight over controls along
      with a shortened body length. The MSG group also showed decreases in locomotor
      and explatory behavior. The 25-day animals took much longer to show effects or
      failed to show any effects, indicating that the MSG-induced changes studied are
      age dependent. Possible methodological considerations accounting for conflicting
      reports in the MSG literature are discussed in light of the present findings.

PMID- 1019186
TI  - Brain 5-hydroxytryptamine correlates of behavior: studies involving spontaneously
      hypertensive (SHR) and normotensive Wistar rats.
AB  - Brain area 5-hydroxytrhptamine (5-HT) turnover and behavioral correlates were
      compared in spontaneously hypertensive rats (SHR) and normotensive Wistar rats.
      SHR appeared to have hyperfunctional 5-HT systems as evidenced by the finding
      that brain area 5-HT turnover times were 53% lower in SHR, with significant
      changes seen in the limbic forebrain. SHR, while less active upon initial testing
      of spontaneous motor activity than Wistar rats, did not habituate as readily to
      the testing procedures as evidenced by higher activity than Wistar rats in
      repeated testing stiuations. In the light of other data indicating that 5-ht
      systems are predominantly inhibitory to ongoing behavior, these data suggest that
      habituation, as determined in this study, is an active process that is retarded
      in the SHR because of hyperfunctional 5-HT systems. Spontaneous activity of SHR
      was inhibited less than that of Wistar rats by a conditioned stimulus which is
      consistent with the observations of others that 5-HT systems tend to suppress
      responsiveness to external stimuli. While spontaneous activity data suggested
      that SHR were more emothinal than Wistar rats, the SHR also exhibited a higher
      avoidance rate in an unsignaled shuttle avoidance procedure which is usually
      indicative of a lower emotional state.

PMID- 1019187
TI  - Abnormal open field behavior after anterolateral hypothalamic injection of 6
      hydroxydopamine.
AB  - To investigate the importance of forebrain catecholamine terminals in open field
      behavior, rats were microinjected bilaterally in the medial forebrain bundle at
      the level of the anteralteral hypothalamus with 6-hydroxydopamine (6-OHDA), a
      specific catecholaminergic neurotoxin. These 6-OHDA microinjections produced
      extensive loss of forebrain catecholamine terminals; identical vehicle
      microinjections did not. When 6-OHDA rats were given 8 open field (OF) tests in
      the first or the fifth postinjection week, they had a longer latency to enter the
      OF, crossed fewer squares and reared less than normal rats or rats microinjected
      with vehicle. The abnormal OF behavior of 6-OHDA rats was not a generalized loss
      of locomotor activity because 6-OHDA rats were normally active in the home cage.
      The abnormal OF behavior of 6-OHDA rats was also not a result of a generalized
      lack of reactivity because the OF test elicited an increase of plasma
      corticosterone in 6-OHDA rats. The possibility that 6-OHDA rats were abnormal in
      the OF because they were hyperractive to it was not consistent with the
      observations that the OF activity of 6-OHDA rats did not change with repetitive
      testing, 6-OHDA rats did not defecate more than vehicle rats, and 6-OHDA rats did
      not display freezing behavior. These results suggest, but do not prove, that the
      abnormal OF behavior of 6-OHDA rats reflects a deficit of exploratory behavior
      that is correlated with extensive loss of forebrain catecholamine terminals.

PMID- 1019188
TI  - The discriminability of apsirin in arthritic and nonarthritic rats.
AB  - Aspirin, 56 mg/kg IP, was shown to be mildly, but significantly discriminable
      from saline in a group of 12 nonarthritic rats exposed to a 2-lever fixed ratio
      10 drug discrimination protocol for 56 trials. In a concurrently-tested group of
      12 rats made arthritic by injection of Mycobacterium butyricum into a hind paw,
      the discrimination of aspirin from saline was enhanced. The results exemplify how
      drug discriminability may vary depending on the pathological state of the
      subjects exposed to drug-discrimination training.

PMID- 1019189
TI  - Behavioral, biochemical and histological effects of prenatal administration of
      progesterone in the rat.
AB  - Pregnant Wistar rats were injected with progesterone (1.5 mg/kg) between Days 8
      and 21 of gestation and the behavioral, biochemical and histological effects of
      this treatment were observed in the offspring. The progesterone offspring weighed
      less than the control animals during this weaning and were retarded on one
      measure of exploratory activity in the open field. None of the other 29 tests
      used showed any significant difference apart from a 9% increase in the amount of
      brain DNA in the progesterone animals. It was concluded that these differences
      were fortuitous and that progesterone has no consistent or significant effects on
      brain development in rodents following prenatal administration.

PMID- 1019190
TI  - Carbachol, angiotensin-II, ventircular spread and water balance in rats.
AB  - Injections into the preoptic areas and anterior hypothalamus of a little as 1.0
      ng/mu1 carbachol (5.5 X 10(-6) M, 11 pmols total dose) and 0.1 ng/mul angiotensin
      II (10(-7) M, 0.2-0.4 pmols) were dipsogenic or antidiuretic-natriuretic. Lateral
      ventricular (VL) thresholds for drinking also were 11 pmols for carbachol and 0.2
      pmols for angiotensin. The low VL threshold for carbachol supports, without
      proving, arguments that a limbic cholinergically-coded thirst circuit could
      reflect leakage form placements near VL to the third ventricle. In contrast, VL
      thresholds for antidiuresis-natriuresis were 110 pmols for carbachol and 2 pmols
      for angiotensin. Carbachol was more effective rostral to the paraventricular
      nucleus and angiotensin dorsal to the supraoptic nucleus. However, lower
      thresholds in these areas were insufficient to localize receptors, since all
      cannulas positive for antidiuresis-natriuresis traversed ventricles, and cannulas
      not traversing ventricles were negative.

PMID- 1019191
TI  - [Reaction of 2,4-dioxo-3,4-dihydro-2H-napth (2,1-e)-1,3-oxazines with hydrazine
      and amines].

PMID- 1019192
TI  - [The determination of the total alkaloid content of Cortex chinae].

PMID- 1019193
TI  - Quantitative determination and identification of pharmaceuticals by means of
      Gran's potentiomentric method.
AB  - A method is proposed both for the quantitative determination and identification
      of pharmaceuticals, based on the data of a single pH-metric titration. As a new
      identification criterion the pK-value of the pharmaceutical is proposed. The
      latter is conveniently determined using the Gran's graphical method. A new
      equation is derived for the data treatment of very weak bases, where the Gran's
      original method can not be applied directly. The proposed method is applied with
      determination and the identification of many pharmaceuticals weak and very weak
      acids and bases.

PMID- 1019194
TI  - Application of some polymers in the physiocochemical design of tablet
      formulation.
AB  - Polyethylene glycol 4000 did not apprecialbly affect the rate of drug release
      from tablets. The use of sodium alginate the a tablet binder showed variable
      effects on the rate of drug release from the tablet i.e. The incorporation of
      only 2.5% of sodium alginate caused enhancement in the release rate of the drug
      based on its action as disintegration inducer. On the other hand, the
      incorporation of 20, 35 and 50% of sodium alginate showed a pronounced
      retardation in the rate of drug release from the tablets. This retardation was
      more pronounced in acid than in alkaline media. Accordingly, sodium alginate
      could be favourably suggested as tablet binder when retarded gastric absorption
      is the therapeutic aim required. Carbopol 940 when used as a tablet binder in a
      concentration of 2.5%, showed a marked enhancement of the release rate of the
      drug. On the contrary, it exerted a remarkable retardation in the rate of drug
      release from the tablets when incorporated in the relatively large proportions of
      20, 35 and 50%. This retardation was more pronounced in alkaline than in acid
      media. Accordingly, Carbopol 940 would be favourably suggested in the
      physiocohemical design of prolonged-release tablet formulations.

PMID- 1019195
TI  - Ethyl cellulose as a potential sustained release coating for oral
      pharmaceuticals.
AB  - This current study was motivated, and designed in an attempt to determine the
      possible application of the inert, pH-insensitive, ethyl cellulose polymer as a
      potential sustained-release coating for oral pharmaceuticals. Coating was
      effected using two relatively recent techniques, namely microencapsulation by
      phase separation coacervation, induced by temperature change, and drug entrapment
      by flocculation, induced by nonsolbent addition. Chloramphenicol was used as a
      model drug. Results of this study revealed the fact that ethyl cellulose proved
      to be a potential sustained-release coating for oral dosage forms. Moreover, the
      effect of the coating/core ratio was exhibited both qualitatively and
      quantitatively. This finding could help in the design of programmed or timed
      release drugs. Accordingly, this study could be considered a successful attempt
      towards the utlization of ethyl cellulose in of the design of sustained-release
      oral pharmaceuticals.

PMID- 1019196
TI  - [Injection molding of oral retard preparations. Part 6. Variations in outer
      surface geometry].

PMID- 1019197
TI  - New generalized equations for multiple dose kinetics by i.v. injection.
AB  - New generalized equations for one compartment open model system with rapid i.v.
      injections for multiple dose kinetics are developed. The model assumers the first
      order elimination. Equations are developed for the maximum and minimum amounts of
      drug in body after n and infinity number of doses. The methods for calculating
      rate of accumulation is presented and the relationship bewteen, f (fraction of
      drug present in the compartment at the time of repeated dosing), t1/2 and the
      dosing interval, tau.

PMID- 1019198
TI  - [Enzyme activities in the blood serum of rats with chronic liver damage. 1.
      Effect of carbon tetrachloride].

PMID- 1019199
TI  - [BESM-6 program for Free-Wilson analysis with automatic forecast of biologically
      active compounds].

PMID- 1019200
TI  - Colorimetric and volumetric determination of organic base reineckates using
      ammonium vanadate.

PMID- 1019201
TI  - Rapid sensitive colorimetric assay for determination of chlordiazepoxide.

PMID- 1019202
TI  - [The antiexudative effect of saponin-5 from Eryngium planum L. and Sanicular
      europaea L].

PMID- 1019203
TI  - [Synthesis of 5-halouracil-protein conjugates by means of isothiocyanate
      coupling. 10. Immunosuppressive-antigen-conjugates].

PMID- 1019204
TI  - Synthesis of 1.2.3.4-tetrahydro-2.4-dioxoquinazoline derivatives for
      pharmacological study.
AB  - The condensation of 4-chloroanthranilic acid with several substituted
      monophenylureas is described. Reacting equimolecular amounts of the
      haloanthranilic acid with monophenylurea, p-tolylurea, p-methoxyphenylurea, p
      ethoxyphenylurea, p-bromophenylurea, p-chlorophenylurea and m-chlorophenylurea-
      by fusion in a pressure bottle--yielded the corresponding 7-chloro-3-aryl-.2.3.4
      tetrahydro-2.4-dioxoquinazoline (1a--g). On the other hand, o-substitute
      phenylureas, instead of affording the expected condensation products, yielded a
      compound which was shown to be 7-chlorobenzoyleneurea (2), the formation of which
      is accounted for.

PMID- 1019205
TI  - [Isomeric l-phenylethylpyridone derivatives from nicotine. 6. Pyridones].

PMID- 1019206
TI  - [Preparation of substituted 5(3)-amino-3(5)-arylsulfonylaminopyrazoles].

PMID- 1019207
TI  - Quantitative determination of ruscogenin in Ruscus species by densitometric thin
      layer chromatography.
AB  - A densitometric t.l.c. method of quantitative determination of ruscogenin was
      elaborated. After separation with the aid of t.l.c., the colourless ruscogenin
      spots were located with the aid of a p-dimethyl-aminobenzaldehyde solution and
      were submitted to densitometry. It was found that under the selected conditions a
      linear dependence exists between the betaI% value and lgC within the range of 0.5
      -10 mug ruscogenin. The determination of ruscogenin is done in the presence of
      the remaining components of the sample. The method is free of any systematic
      error. The method was applied in the determination of the ruscogenin content of
      the above-ground and underground part of Ruscus aculeatus and R. hypoglossum,
      extracts of the same plants, and capsules with further to the R. aculeatus
      extract also contained bioflavonoids. It was found that the content of ruscogenin
      in the underground and the above-ground parts of R. hypoglossum is 0.14 and
      0.10%, respectively, while for R. aculeatus the respective values are 0.12 and
      0.08%. The extract contains 1.6% ruscogenin, and the capsules 0.09 mg each.

PMID- 1019208
TI  - [Quantitative determination of N,N'-bis-[3-(2'-ethoxyphenoxy)-2-hydroxypropyl]
      ethylenediamine dihydrochloride (Falirytmin) in blood].

PMID- 1019209
TI  - [UV-Spectrophotometry in drug control. 19. New drugs with substituted benzene
      chromophores].

PMID- 1019210
TI  - [Methods of pharmaceutical analysis: analysis of information flow].

PMID- 1019211
TI  - [Relationship between the micelle bond body and the photoinstability of
      solubilized menadione. 6. The use of intermediary solvents as an aid in the
      production of drugs].

PMID- 1019212
TI  - [The preparation of eutectic-forming drugs. 3].

PMID- 1019213
TI  - [Antiarrhythmic, cardiovascular and toxic actions of N,N'-bis-[3-(2'
      ethoxyphenoxy)-2-hydroxypropyl]-ethlenediamine (Falirytmin) as compared to
      propranolol, quinidine and ajmaline].

PMID- 1019214
TI  - [Quantitative chemical data as factors in a quantitative structure-activity
      analysis].

PMID- 1019215
TI  - Investigations of nicandrenone--a withanolide-like aromatic plant steroid from
      Nicandra physaloides.
AB  - On the basis of IR, UV, ORD, NMR and high resoluted mass spectral data as well as
      chemical transformations, evidence for structure 1 of the D-homo-aromatic plant
      steroid nicandrenone from Nicandra physaloides (Solanaceae) was given. The
      sterochemistry of both epoxy lactol functions in this compound was established
      using intramolecular hydrogen bonding investigations. Biogenetical aspects are
      discussed.

PMID- 1019216
TI  - Isolation of dihydroflavonol from Pulicaria undulata (L.) Kostel.

PMID- 1019217
TI  - Investgation of the Volatile oil of Saudi Lavandula dentata.

PMID- 1019218
TI  - [Molecular galenics. 14. The mechanism of tablet formation].

PMID- 1019219
TI  - [Molecular galenics. 15. Determination of pressure distribution in tablets as a
      variation of the classification grade].

PMID- 1019220
TI  - [Molecular galenics. 16. The increase of inner energy in a stable system by
      single and multiple pressing].

PMID- 1019221
TI  - Age dependent acute toxicity of ethylmorphine.

PMID- 1019222
TI  - [Alkaloid and steroid sapogenin content of Solanum verbascifolium L].

PMID- 1019223
TI  - [The effects of propolis on bacteria].

PMID- 1019224
TI  - [Preparation for industrial production of pilocarpine eye drops].

PMID- 1019225
TI  - Cardiovascular activity of 9-hydroxy-ellipticine.
AB  - The cardiovascular activity of 9-hydroxy-ellipticine (9-OH-E) has been studied on
      anaesthetized dogs. The drug has been administered intravenously in one dose
      ranging from 1 to 10 mg/kg. The variations in the myocardial contractility, the
      systemic haemodynamics, the respiration and the general metabolism of the
      anaesthetized dogs were studied to make evident the mechanism of 9-OH-E
      cardiostimulating action. 9-OH-E from 5 mg/kg i.v. stimulates the contractility
      of myocardium and improves the cardiac performances of the anaesthetized dogs.
      This heart-stimulating action is long-lasting and is not accompanied by any
      modification in the arterial blood pressure. It is inhibited or at least strongly
      attenuated by beta-adrenergic blocking agents and by the depletion of
      catecholamines.

PMID- 1019226
TI  - Antithrombotic effects of sulfinpyrazone in animals: influence on fibrinolysis
      and sodium arachidonate-induced pulmonary embolism.
AB  - It has been shown that sulfinpyrazone stimulates fibrinolytic activity in various
      in vitro and in vivo test systems. In rats with kaolin-induced paw oedema this
      compound is able to restore the markedly prolonged euglobulin clot lysis time in
      an oral dose of 30 mg/kg, whereas salicylate and dipyridamole are somewhat less
      active in this respect. Beside these effects, sulfinpyrazone protects rabbits
      from arachidonate-induced sudden death after a single oral dose of 10-30 mg/kg.

PMID- 1019227
TI  - Effects of calcium infusion on secretion and motor activity of totally isolated
      canine stomach perfused with homologous blood.
AB  - Isolated, ex vivo perfused, canine stomachs were used for this study. Gastric
      secretion, myoelectrical activity and mechanical activity were recorded during
      stimulation of gastric function with pentagastrin or histamine alone or combined
      with calcium gluconate. Secretagogues and calcium were infused into the gastric
      arterial circulation. Hypercalcemia induced significant inhibition of
      pentagastrin, stimulated gastric secretion, but did not affect the secretion
      stimulated by histamine. Hypercalcemia also induced an increase of frequency of
      cycles of electrical control activity and a decrease of mechanical activity of
      the gastric antrum. The effect of hypercalcemia on gastric motor function was
      similar in the nonstimulated stomach and during the infusion of secretagogues
      used in this experiment.

PMID- 1019228
TI  - Influence of surgical manipulations on hexobarbital effects in rats.
AB  - In rats the hexobarbital metabolism is impaired after different surgical
      procedures leading to muscle damage. This leads to a prolongation of the
      hexobarbital action. The prolonged effect of hexobarbital in rats with
      lymphostatic encephalopathy is considered an unspecific consequence of the tissue
      damage during lymphectomy.

PMID- 1019229
TI  - Sex and genetic differences in the elimination of sulphadimidine in rats.
AB  - Rats of five inbred strains and two random-bred stocks were intravenously given
      sulphadimidine (40 mg/kg body weight). A relatively low percentage of
      acetylsulphadimidine (Ac-S) in urine and absence of strain differences were found
      in males, whereas two phenotypes can be distinguished in females: (1) high
      percentage of Ac-S in urine, and (2) low percentage of Ac-S in uirne. An
      autosomal control of these differences is suggested. A dominant allele which
      determines the high percentage of excreted Ac-S manifests itself only in female
      endo-environment.

PMID- 1019230
TI  - The observation and analysis of cancer deaths among classified radiation workers.
AB  - The extent to which occupational radiation exposure contributes to cancer
      mortality is an influence on future world energy policy. It is also a factor in
      deciding the level  of expenditure to reduce radiation levels experienced by
      workers. Here we discuss some of the difficulties in analysing the situation  and
      present the results of some calculations which estimate the expected age-specific
      radiation mortalities from all inducible cancers and also from leukaemia
      separately. Using a high value for the average occupational exposure and a
      conservative estimate of the associated risk, we find that a survey of mortality
      among radiation workers must run over many years before sufficient data would be
      accumulated to resolve the effects of radiation-induced neoplasms from those
      arising from other causes. We show the advisability of determining the cause of
      death both of persons who remain employed in the industry and all for only a
      short time. Our estimates are based on maintenance of an occupationally exposed
      dose of one rad per person per year during the period of the survey which may
      extend over several decades. However, scaling of the estimates to any other
      exposure rates is easily performed. We also give estimates of the lowest risk
      coefficients detectable in a given observation time. Since for a work force of
      3000 these lowest detectable values are an order of magnitude larger than those
      expected, it is clear that only a national or international survey can produce
      data adequate for even modest objectives.

PMID- 1019231
TI  - The influence of cosmetics and ointments on the spectral emissivity of skin.
AB  - Measurements of the spectral emmissivity, epsilon (lambda), of human skin
      described in a previous paper were performed with a modified monochromator by
      comparing the radiation from the skin with blackbody radiation in the wavelength
      range between 2 and 14 mum. Using the same equipment the spectral emissivity has
      been measured of skin which had been covered with different cosmetics and
      ointments. From these data it is possible to predict theoretically the apparent
      temperature difference as seen by an infrared scanner or radiometer with a
      detector of which the spectral detectivity, D (lambda), is known. These values
      are compared with the readings of a Bofors Thermograph with an InSb detector.
      When talcum venetum has been applied to the skin, a greater apparent temperature
      diffenence must be expected for thermographic cameras equipped with a HgCdTe
      detector than for cameras with InSb detectors.

PMID- 1019232
TI  - Stripping-theory analysis of thick-target neutron production for D + Be.
AB  - The Serber theory for deuteron stripping is employed to predict the shape of the
      neutron energy spectrum produced by 35 MeV deuterons (D+) on a thick beryllium
      target. In particular, the observation that the maximum of the neutron energy
      spectrum (at 0degrees relative to the deuteron beam direction) occurs at
      approximately 0-4Ed, where Ed is the incident deuteron energy, is explained
      reasonably well by the calculations. The explanation stems mainly from the fact
      that the stripping theory for thin targets predicts a narrow maximum at 0-5Ed,
      and thick target effects shift the maximum downward in energy to approximately 0
      4Ed. A number of recent spectral measurements are in agreement with these
      predictions for a wide range of target materials and incident deuteron energies.
      The application of this theory also accounts for the previously observed Dd2-99
      dependence of the absorbed dose in tissue,per unit charge of D+ ions on target,
      in the direction of the incident beam. This approximate Ed3 dependence is shown
      to be a characteristic property of deuteron stripping in a thick target and
      follows directly from the calculations that predict the neutron energy spectrum.

PMID- 1019233
TI  - Further results in nuclear scattering radiography.
AB  - A further investigation of the nuclear scattering of 500-1000 MeV protons is
      described. Three-demensional information on the desity distribution within
      carbon, CH and H2O phantoms is obtained with a volume resolution of 2 mm3. The
      separation of scattering on hydrogen from that on heavier nuclei, such as carbon
      and oxygen, is demonstrated, providing the statistics are sufficient. Some
      preliminary measurements on animals are reported, but with a volume resolution
      limited by statistics to 43 mm3.

PMID- 1019234
TI  - Gamma dosimetry with Al2O3 thermoluminescent phosphor.
AB  - Preparation of thermoluminscence (TL) dosimetric grade A12O3 powder and pellets
      five times more sensitive than TLD-100 is described. Glow peaks at 50, 125, 250,
      325, 475 and 625 degrees C with emission in the blue region have been observed;
      Si and Ti have been identified as the impurities responsible for TL in  this
      phosphor. Studies of the TL growth rate with exposure showed that the 250 degrees
      c peak grew linearly up to 400 R and then at a supralinear rate of (exposure).
      The growth of the 475 degrees c peak was almost linear at a rate of (exposure) 1
      05, while that for the 625 degrees C peak was sublinear at (exposure) 0-85. The
      250 and 475 degrees peaks together show a linear response up to 40 000 R. The
      phosphor had no light sensitivity and is very well suited for gamma dosimetry as
      pellets or powder. Studies of sensitization and supralinearity, with sensitizing
      exposure, sensitizing anneal temperature and test gamma and alpha exposures are
      reported. Initially filled 625 degrees C TL related traps were found to be
      essential for sensitizaiton. Supralinearity and sensitization in Al2O3 phosphor
      could be consistently explained by the deep trap model.

PMID- 1019235
TI  - Proton microbeam analysis in air.

PMID- 1019236
TI  - A preliminary investigation of nuclear resonant scattering as a new technique for
      the in vivo measurement of hepatic copper.

PMID- 1019237
TI  - Self-shielding factors for TLD-600 TLD-100 in an isotropic flux of thermal
      neutrons.

PMID- 1019238
TI  - The effect of obliquity in clinical thermograms.

PMID- 1019239
TI  - Effects of tissue inhomogeneities on dose patterns in cylinders irradiated by
      negative-pion beams.

PMID- 1019240
TI  - Neutron flux uniformity in in vivo neutron activation analysis.

PMID- 1019241
TI  - Electrical conductance characteristics of some human erythrocyte membranes.

PMID- 1019242
TI  - Dose variation in X-ray epilation for tinea capitis.

PMID- 1019243
TI  - Independence of photoproduct formation on DNA conformation.

PMID- 1019244
TI  - Bilirubin-sensitized photoinactivation of enzymes in the isolated membrane of the
      human erythrocyte.

PMID- 1019245
TI  - A photochemical mid-ultraviolet dosimeter for practical use as a sunburn
      dosimeter.

PMID- 1019246
TI  - The effect of environmental light exposure on drug-induced porphyria in the rat.

PMID- 1019247
TI  - Evaluating the stability and reactivity of a light-sensitive probe by enzyme
      analysis.

PMID- 1019249
TI  - Indication of fast triplet formation in bimolecular quenching of excited singlet
      states studied by conventional flash photolysis.

PMID- 1019248
TI  - The sunburning ultraviolet meter: design and performance.

PMID- 1019250
TI  - Target organ for a systemic effect of ultraviolet radiation.

PMID- 1019251
TI  - Effects of pigment heterogeneity on fluorescence in photosynthetic units.

PMID- 1019253
TI  - Measuring subnanosecond fluorescent lifetimes using photon counting.

PMID- 1019252
TI  - The non-chemiluminescent reaction of luminol with singlet oxygen.

PMID- 1019254
TI  - Emission spectrum differences in fluorescent blacklight lamps.

PMID- 1019255
TI  - The interaction of salts, amides, and water.
AB  - Infrared and Raman spectra are presented for salt solutions in N-methyl formamide
      and N,N'-dimethylformamide. Viscosities are reported for many of these solutions.
      Spectroscopic and viscosity data are also given for amide-salt solutions
      containing water. The three-component systems exhibit a hydrogen-bonding strength
      of water proton greater than amide proton, and an acceptor strength of Cl-
      greater than amide carbonyl oxygen greater than water oxygen. The salt cation is
      deduced by means of viscosity measurements to interact strongly with the amide
      carbonyl oxygen, even in the presence of appreciable quantities of water.
      Association of amides by hydrogen bonding through halide ions is also indicated.

PMID- 1019256
TI  - Effect of the hepatocarcinogen ethionine on hepatic messenger RNA synthesis.
AB  - An experiment was conducted to determine if any changes resulted in the
      proportion of hepatic messenger RNA following treatment with ethionine, a
      hepatocarcinogen. The relative specific activity of the total RNA isolated from
      nontumor-like tissues was increased in Sprague-Dawley rats fed ethionine.
      However, the percentage of total RNA that was message was found to be decreased
      in the ethionine-treated rats.

PMID- 1019257
TI  - Hyperosmotic oxidation of glucose and decarboxylation of histidine in the gastric
      mucosa.
AB  - Paired slices of rat gastric mucosa were incubated with labeled glucose or
      histidine in isosomotic solution of 3-fold hyperosmotic solutions concentrated in
      NaCl, KCl, or ethanol. The rate of (1-14C)glucose oxidation to 14CO2 in isosmotic
      solution was reduced by 74% in hyperosmotic NaCl and by 28% in hyperosmotic KCl.
      The rate of (6-14C)glucose oxidation to 14CO2 in isosmotic solution was reduced
      by 64% in hyperosmotic NaCl and by 53% in hyperosmotic KCl. Reductions of glucose
      oxidation in hyperosmotic ethanol were not significant. The ratio of 14CO2 formed
      from (1-14C)glucose to that formed from (6-14C)glucose was not significantly
      changes by hyperosmotic NaCl or ethanol, but was significantly raised by
      hyperosmotic KCl. The rate of (carboxyl-14C)histidine decarboxylation in
      isosomotic solution was reduced significantly by 48% in hyperosmotic NaCl, by 30%
      in hyperosmotic KCl, and by 27% in hyperosmotic ethanol. We conclude that
      hyperosmotic solutions reduce glucose oxidation and histidine decarboxylation by
      rat gastric mucosa in the order of potency: NaCl greater than Kcl greater than or
      equal to ethanol. Thus hyperosmotic solutions inhibit the source of metabolic
      energy for stimulated acid secretion, the citric acid cycle, and the formation of
      the secretagogue histamine.

PMID- 1019258
TI  - Subcellular distribution and electrophoretic behavior of aminopeptidase in human
      placenta.
AB  - The activity of aminopeptidase was found by differential centrifugation to be
      distributed in the three main subcellular sites of human placenta: the lysosomal
      mitochondrial, microsomal, and supernatant fractions. Placental lysosomes were
      isolated from the lysosomal-mitochondrial fraction and identified by electron
      microscopy. The lysosomal and microsomal aminopeptidases presented different
      electrophoretic patterns, suggested the existence of multiple molecular forms of
      aminopeptidase within the human placenta. Serum aminopeptidase appearing during
      pregnancy showed the same bands as those of the lysosomal enzyme. This finding
      suggests that the increased aminopeptidase in pregnancy serum may originate from
      the lysosomes of the placenta. Placental aminopeptidase bands were absent in
      fetal serum. The supernatant contained most of the total activity, which turned
      out to be due to contamination of this fraction by retroplacental blood.

PMID- 1019259
TI  - Urinary chelates in penicillamine-induced cupuresis. Negative evidence for the
      involvement of a red-violet complex of copper and penicillamine in rabbits.

PMID- 1019260
TI  - Kinetics of the light flash of the living firefly: a supramolecular process.
AB  - The light intensity vs. time curve of the light flash of the living firefly has
      been measured. Unlike the purified firefly enzyme system in aqueous solution, the
      living system does not show light decay conforming to a double exponential time
      curve, to simple first or second order decay, or to solid-state Elovich kinetics.
      Light decay of the living flash does show linearity in a probit vs. square root
      of time plot, which may indicate a reaction rate-limited by cooperative
      interactions of a biological phase transition. The observation that the kinetics
      of the firefly light system differ in the living cell from those in the purified
      system suggests that in the living system supramolecular factors control the rate
      of the reaction.

PMID- 1019261
TI  - [Mutism as permanent catatonic condition].
AB  - The history of a case of mutism, where the patient had been silent for more than
      twenty-five years, caused by the author to study and discuss this relatively
      infrequent catatonic symptom which is a type of schizophrenia, with frequent
      references being made to the results of psychiatric studies made by authors
      ranging from Kahlbaum to Leonhard. Permanent mutism as a possible phenomenal form
      was logically classified, by Leonhard, as a type of mannered catatonia.

PMID- 1019262
TI  - [Attitude changes in alcoholics - demonstrated in phasic course of treatment].
AB  - The constant change in attitude to personal "alcohol problems" of patients
      treated on an inpatient or out patient basis is described with reference to the
      phasic course of treatment and the deviations therefrom. It is essential that
      this be taken into account in both group and individual therapy, more especially
      as this will lead to favorable psychagogic and psychotherapeutic approaches.

PMID- 1019263
TI  - [Some psychodiagnostic relevant personality variables of mothers of
      psychosocially abnormal children and adolescents].
AB  - One hundred mothers of psychosocially abnormal children and juveniles were
      subjected to a clinical and psychological examination by means of the INR
      questionnaire containing 70 questions to be answered. Neurotic and near-neurotic
      personalities and behavior patterns could be objectified in 71 percent of the
      subjects. Only 29 percent of the mothers tested gave normal psychological test
      results. The two groups of subjects were different in regard of both the
      intactness of marital relations and the ideational images of, and reasons given
      by, their children. The relatively large number of mothers showing negative
      psychological test results again underscores the need for intensive medical and
      psychological care of such persons and parents, respectively, in order to be able
      to make subsequent and effective corrections of psychic maldevelopments in
      adolescents.

PMID- 1019264
TI  - [Aqueduct syndrome].

PMID- 1019265
TI  - [Psychotropic drugs for behavior disorder treatment in oligophrenic epileptics].
AB  - Forty-one patients were treated with promazine, a phenothiazine derivative, for
      an average of 266 days. The average daily dose was 200 mg. Thirty patients were
      treated with levomepromazine for an average of 115 days, the daily dose being
      about 130 mg. The two groups of patients were examined for their contactual,
      impulsive, and affective behavior before, during, and after treatment. The
      positive results obtained justify the use of the above-mentioned
      psychopharmaceuticals for the therapy of abnormal behavior of oligophrenic
      epileptics.

PMID- 1019266
TI  - [Future of neuropsychology].
AB  - The future development of neuropsychology as an independent discipline, which has
      as its principal subject the relationships between the brain as a material
      substrate and the psychic behavior shown by human beings as well as animals, is
      discussed on the basis of a schematic presentation of the possible structure of
      this discipline (general, genetic, clinical and pathological, and applied
      neuropsychology.

PMID- 1019267
TI  - [Role of countertransference in complex psychotherapy].
AB  - The psychotherapist has a key position in any psychotherapeutic situation,
      participating in the psychotherapeutic process with all his personality and
      responding both consciously and unconsciously to the patient and the entire
      psychotherapeutic system. Countertransference consists of those actions and
      emotional manifestations on the part of the psychotherapist, which originate from
      his unconscious strata as a reaction to the overall situation. The existence of
      countertransference and its possible interference with, and perhaps adverse
      effect on, the psychotherapeutic process require close scientific and social
      controls. Also, it will be necessary to make "self-experience" psychotherapy
      (educational analysis) a required subject. Countertransference also has important
      perception- and empathy-promoting functions.

PMID- 1019268
TI  - [Problems and aspects of cooperation between pedagogs, youth health professionals
      and pediatric neuropsychiatrists in rehabilitation of behavior and achievement
      disorders in children with normal intelligence].
AB  - In those cases where the subjects involved tend to show pathological
      psychophysical reactions, it is necessary for a cooperative effort to be made by
      pedagogs, psychologists, and medical experts (pediatricians and
      pedoneuropsychiatrists). This may be realized by patient-related corrdinative
      consultations or psychotherapeutic treatment and subsequent individual pedagogic
      promotion and encouragement depending upon the degree of manifestation and
      generalization of the disorders. The use of various methods (modified but
      predominantly pedagogic and directive approaches and chiefly psychological and
      nondirective methods of treatment, respectively) involve different
      responsibilities of experts for the process of rehabilitation (in regard to both
      time and content). Also, the authors show that this is not in contradiction to
      general objectives of education and training and that every effort is made to
      reconcile medical and psychological objects with pedagogic requirements.

PMID- 1019269
TI  - [Lymphocyte sensitivity to brain specific glycoprotein in multiple sclerosis].
AB  - The lymphocytes of seven out of eight multiple sclerosis patients were sensitized
      to brain-specific glycoproteins that had been isolated from extracts of human
      white matter and purified by means of affinity chromatography utilizing specific
      antibodies as immunoadsorbents. The diagnosis of multiple sclerosis for the
      eighth patient, whose lymphocytes were not sensitized, was doubtful. A
      significant correlation between the severity of the disease and degree of
      lymphocyte sensitization was not obtained, although the most disabled patient
      showed the greatest sensitization.

PMID- 1019270
TI  - [Sex distribution of EEG phenomena with particular reference to subcortical
      dysfunctions].
AB  - The most constant or continually recurring sexual difference observed from
      childhood through to old age and determined from the results of a total of 1500
      electroencephalograms was a considerable increase in beta activity occurring in
      female individuals at an earlier time and at a higher rate. The more frequent
      observation in male individuals of a "pure" alpha electroencephalogram may be
      interpreted as suggesting a slight decrease of vigilance in them. The percentage
      of abnormal electroencephalographic results was highest in females, the
      proportion being 62.5%:51.5% and the functional disorders occurring chiefly in
      the form of subcortical dysfunctions (30%:20%). Low voltage was found to be
      predominant in males. More frequent occurrence in the female sex of weakness of
      the brainstem and a more sensitively reacting formatio reticularis may be
      considered a possible explanation; also, attempts are made to bring the results
      obtained into causal or reciprocal relation to psychic conditions. Beta activity
      is perhaps a parameter of emotionality.

PMID- 1019271
TI  - [O2 multistep method as a supplement to therapy of standard brain energy balance
      disorders].
AB  - The possibility of improving the brain's energy state by the O2 multistep method
      is discussed. An outline is given of several variations of the O2 multistep
      method, and this is followed by a discussion of the results of studies of the
      increase and decrease in concentration of high-energy phosphates in the brains of
      rats during and after the O2 multistep process. In conclusion, the author reports
      a twin series of tests where psychic irritations lasting for a short time only
      were triggered and in which such irritations were suppressed through using the O2
      multistep procedure.

PMID- 1019272
TI  - [The EEG in subacute sclerosing panencephalitis (SSPE)].
AB  - This article gives an overview of electroencephalographic results obtained in the
      case of subacute sclerosing panencephalitis. Severe disturbances of background
      activity have been observed in all patients. Repetitive complexes usually occur
      transitorily, so that they cannot always be detected in individual cases.
      Repetitive complexes must be regarded as being typical of the disease, and
      consideration must be given in this connection to their particular
      characteristics (repetition frequency, constancy of form, relations to disorders
      characterized by myoclonus) and the clinical picture.

PMID- 1019273
TI  - [Extrapyramidal syndromes as side-effects of metoclopramide (Cerucal)
      medication].
AB  - The authors, by describing their own observations made on eight patients showing
      extrapyramidal syndromes as side effects of metoclopramide (Cerucal) medication,
      report the various kinds of possible side effects, discussing their conformity
      with side effects produced by conventional neuroleptics and showing methods of
      treatment. Metoclopramide is known to produce three froms of extrapyramidal and
      motor side effects, namely: 1. Dyskinetic syndrome; 2. acathisia; and 3.
      Parkinson's syndrome. Therapy is in the following form regardless of the
      particular side effect produced by the said drug: 1. Administration of
      antiparkinsonian remedies; 2. administration of coffein; and 3. discontinuation
      or drastic reduction, respectively, of the daily dose of Cerucal.

PMID- 1019274
TI  - [Delimitation and cooperation between pediatric neuropsychiatry, child health
      protection, psychology and pedagogy in the diagnosis, treatment, and
      rehabilitation of behaviorally disturbed children with normal intelligence].
AB  - This article describes the complexity and dynamics of the disease with reference
      to the diagnosis of "behavioral disorder in the case of normal intelligence". In
      addition, the authors discuss differences in manifestation and the need for
      cooperation between experts in pedoneuropsychiatry and clinical psychology, on
      the one hand, and pedagogics and special education, on the other.

PMID- 1019275
TI  - [Adrenoleukodystrophy. Clinical-pathologic case history and literature review].
AB  - This article presents the clinical and pathological history of a 10-year-old boy
      with adrenoleukodystrophy as well as a tabular survey of 17 additional cases of
      which the necropsy records were published in the literature. So far as the case
      of adrenoleukodystrophy directly observed by the authors themselves is concerned,
      commencement of the disease was in the seventh year of life, with symptoms of
      Addison's disease and diffuse inflammatory cerebral sclerosis being observed at
      about the same time. The cerebral disease manifested itself as a progressive
      pseudobulbar and pyramidal tract symptomatology and as a progressive cerebral
      psychosyndrome reminiscent of an endocrinal psychosyndrome. Morphologically, the
      adrenoleukodystrophy was characterized by severe dystrophy of the cortex of the
      suprarenal gland and the brain are considered the points of action of a still
      unknown noxa.e suprarenal gland as well as by extensive sudanophilic processes of
      decomposition in the cerebromedullary substance, putamen, pallidum, and thalamus.
      Striated cells and cytoplasmic filamentous inclusions observed in the brain and
      suprarenal glands in a number of cases reported in the literature were not found
      by the present authors. The cortex of th

PMID- 1019276
TI  - [The nosotropic effects of psychopharmaceuticals].
AB  - The spectrum of pharmacogenic pathomorphosis has been found to be also dependent
      upon the forms of disease, i.e., the special morbogenic factors. Two opposed
      types of nosotropy of psychopharmaceuticals, namely, protective and nosogenic
      nosotropy, are considered in dependence on the pharmacotherapeutic effect
      produced and the mode of clinical action. Protective and nosogenic nosotropy may
      be observed to be active simultaneously and result in characteristic paradoxes of
      the psychopharmacotherapy of endogenous psychoses.

PMID- 1019277
TI  - [Rheoencephalographic examinations of a patient with "coughing syncopes"--a
      contribution to etiology].
AB  - This is a report of a patient showing the clinical picture of syncopes due to
      coughing, who has been examined by rheoencephalography. Three different varitions
      of syncopes due to coughing are discussed with particular reference to the
      factors involved.

PMID- 1019278
TI  - [Preliminary results of imurek treatment of multiple sclerosis].
AB  - The authors, after presenting a survey of the literature on the treatment of
      multiple sclerosis with immunosuppressants, report their experience with Imurek.
      Of 53 patients with a chronic and progressive course of the disease, objective
      improvement could be observed in 17. In 20 patients the symptomatology remained
      unchanged, although 4 of them reported subjective improvement. In 16 patients,
      progression of the disease could not be stopped. Better results of treatment
      could be obtained for those forms of the disease where the course was, first, in
      the form of what may be referred to as outbursts and, later, in a chronic and
      progressive form. -Possible side effects are pointed out.

PMID- 1019279
TI  - Sleep-assisted instruction.

PMID- 1019280
TI  - Spontaneous remission in adult neurotic disorders: a revision and summary.

PMID- 1019281
TI  - Initial drug abuse: a review of predisposing social psychological factors.

PMID- 1019282
TI  - Tactile-kinesthetic space estimation: the influence of gravity.

PMID- 1019283
TI  - Monaural and binaural temporal integration of noise bursts.

PMID- 1019284
TI  - Spatial and fixation conditions affecting the temporal course of changes in
      perceived relative distance.

PMID- 1019285
TI  - [Comparative aspects of penal sanctions].
AB  - A conference on comparative aspects of criminal sanctions has been held at the
      Aspen Institute, Berlin, on February 2 to 6, 1976, assembling experts from Europe
      and from the United States, The focus has been on guidelines for prevention of
      crime and treatment of offenders, with a view to examine differences and
      convergences among various national criminal justice systems. Specific tropics
      under discussion have been: the goals of dention, alternatives to detention,
      sentencing and releasethe conditions of detention, the future of research in the
      field. Priority areas for further study were considered to be: prevention of
      crime, arrest and sentencing procedures, grievances procedures, the dangerous
      offender, protection of victims, of jurors and of witnesses, treatment of
      juveniles, information of the public.

PMID- 1019286
TI  - [Methods of evaluation of problems related to drug abuse].
AB  - The enactment of a new drug law in Italy, brinaing with it special requirements
      for reporting on distribution of many controlled substances, provides an
      opportunity for the construction of an information system that can greatly assist
      in planning drug-related programmes. The Author summarizes the various types of
      drug information that can be collected from various points in the reporting
      network and suggests this system could be operated at relatively low cost of it
      were implemented in Italy in the very near future.

PMID- 1019287
TI  - [Territorial experiment: inter-relational evolution of a group of inmates in the
      course of an extra-institutional working experiment].
AB  - The Authors analize the interrelational evolution of a group of inmates during an
      outside working activity, with relation to the resocializing experiences which
      consider the insertion in the area of individuals subjected to detentive security
      measures. Such evolution, in relation with the influences of the social
      enviornment one was associated with, was associated with, was marked by an
      initial cohesion stage between members (of defensive significance), followed by a
      gradual research of a personal autonomy, in parallel with the acquisition of a
      reassuring and stabilized role. The utilization of a social space according to
      the conventional parameters used in the area (with particular concern towards
      syndical dynamics and rules), reached at the cost of self-exposure, has confirmed
      the reached maturity and the self balance in proposing themselves to the others
      as subjects active in their own resocialization, sharing the acquired social
      rights. Beside the situation concerning the side of the group in its insertion
      progress, the Authors take into examination the side of the free community in tis
      receptivity and availability towards the group members, analizing the
      interactions with the environment as therapeutical moment.

PMID- 1019288
TI  - [Effect of serum storage on the determination of triglycerides and cholesterol
      (author's transl)].

PMID- 1019289
TI  - [Indications for study of adrenal function by measurement of the cortisol
      secretion rate].
AB  - Results of routine methods for measurements of plasma cortisol and his urinary
      metabolites have been comparated with those of cortisol secretion rate (CSR)
      measured by simple isotopic dilution; the latter appears for his specify and
      precision, to be the most suitable for an exact evaluation of cortisol production
      by the adrenals. In normal subjects CSR resulted slightly lower than those
      reported in the literature; in obese subjects CSR was slightly higher than in
      normals, also when it was related to the urinary creatinine. In the patients with
      Cushing's syndrome, CSR was considerably higher, with no overlap with the obese
      subjects. The CSR was also useful in showing values lower than normal, in
      hypopituitarism, and in confirming hormone abnormal findings in thyroid diseases.

PMID- 1019290
TI  - [The validity of determination of serum pseudocholinesterase (PCH) in the
      differential diagnosis of chronic hepatopathies].

PMID- 1019291
TI  - [Hepato-Quick: a new diagnostic test for liver diseases (author's transl)].
AB  - The AA. have adopted usual biohumoral examinations and the Hepato-Quick test for
      a group of patients affected by various liver diseases. Hepato-Quick contains
      thromboplastine from monkey brain and plasma absorbed on barium sulphate. It is
      particularly sensitive for II, VII and X factor and it does not react on deficit
      of V factor and fibrinogen both already present with optimal concentration in the
      Hepato-Quick test. II, VII and X factor are synthetized by the liver and reveal
      in an outstanding way every hepatocytic lesion: therefore is the Hepato-Quick
      test a fine and responsive test for the liver function and in order to control
      the liver diseases, especially if chronic. We have seen the new test is strong
      altered by hepatic cirrhosis, but there are no significant alterations in
      different liver diseases.

PMID- 1019292
TI  - [A new standardized method for determination of the bleeding time].
AB  - The standardized bleeding time is considered a valuable measure of the platelet
      role in haemostasis. It is particularly useful for the evaluation of drugs that
      affect platelet functions. Measurements of the bleeding time were performed using
      a new system which was designed following the instructions of Mielke and co
      workers with some variations of the described method. The standardized bleeding
      time proved to be a high reproducible and sensitive technique.

PMID- 1019293
TI  - [Determination of proteins in cerebrospinal fluid by sensitive biuret method
      (author's transl)].

PMID- 1019294
TI  - [Micro-method for determining serum bilirubin (author's transl)].
AB  - A single, rapid, precise and automatizzable micro-method for determining serum
      bilirubin has been described. The method requires a little while of serum. It is
      possible reader the bilirubin concentration at last of 30 mg/100 ml without of
      serum dilution. The determination of "direct bilirubin" has been examined in
      connection with the reaction time. The reliability of the our diazo-method has
      been established by comparison with well-known diazo-methods and by demonstrating
      the effect of hemolysis.

PMID- 1019295
TI  - The promotion of health.

PMID- 1019296
TI  - The world situation.

PMID- 1019297
TI  - Asbetos--health hazards in perspective. Constructional uses.

PMID- 1019298
TI  - Current information on the health risk of asbestos.

PMID- 1019299
TI  - Safety measures when handling asbestos.

PMID- 1019300
TI  - The menace of pollution--fact or fiction? Pollution: myth or menace?--measure it!

PMID- 1019302
TI  - The assessment of health effects of pollution.

PMID- 1019301
TI  - Planning for the control of pollution.

PMID- 1019303
TI  - [Application of serum LDH and MDH activities for controlling the course of
      radiotherapy of breast and uterine cancer. Preliminary communication].

PMID- 1019304
TI  - [Intestinal changes before the beginning of radiation therapy and their effects
      on the course of radiogenic intestinal responses during radiation therapy of
      gynaecological tumours (author's transl)].

PMID- 1019305
TI  - [Causuistic examples of differential diagnosis of tumour cytology from fluids and
      body cavities (author's transl)].

PMID- 1019306
TI  - [The free amino acid content in plasma and erythrocyte hemolysates of uranium
      miners (author's transl)].

PMID- 1019307
TI  - [On the biological behaviour of mamma carcinoma of C3H-mouse in
      hyperfractionation (author's transl)].

PMID- 1019308
TI  - [The dynamics of ultrastructural changes of the nucleus and of the chondrioms in
      the process of thymocyte death after irradiation (author's transl)].

PMID- 1019309
TI  - Chromosomal radiosensitization by bismuth in Vicia faba.

PMID- 1019310
TI  - [Reparative processes on the duodenal mucosa of irradiated mice after treatment
      with Ionol (author's transl)].

PMID- 1019311
TI  - [Changes in lysosomal osteoblast apparatus in combined trauma (author's transl)].

PMID- 1019312
TI  - [Recovery of rat duodenal mucosa after abdominal gamma-irradiation with lethal
      doses (author's transl)].

PMID- 1019313
TI  - Rate of lens lesion development and of the age of mice at time of irradiation.

PMID- 1019314
TI  - [Measurement of strongly inhomogeneous activity distributions in radio paper
      chromatography--using 131I-Rose Bengal as an example].

PMID- 1019315
TI  - [A simple unit for electronic influencing and reproduction of X-ray pictures
      (author's transl)].

PMID- 1019316
TI  - [On the statement value of measuring results of the central personal monitoring
      in gynaecological brachy therapy (author's transl)].

PMID- 1019317
TI  - [Continuing education in radiation protection for medical institute specialists
      and directors].

PMID- 1019318
TI  - [The influence of radioiodine therapy on the content of sulphhydryl groups in
      blood serum in toxic struma (author's transl)].

PMID- 1019319
TI  - [The telecobalt mantle-field irradiation of lymphogranulomatosis (author's
      transl)].

PMID- 1019320
TI  - [Validity coefficient as comparative figure for the applicability of methods of
      carcinoma diagnosis (author's transl)].

PMID- 1019321
TI  - Labelling of glutamine acid with 113mIn for scintigraphic examinations of liver
      and spleen.

PMID- 1019322
TI  - The influence of ionizing radiation on intestinal absorption of amino acids and
      their incorporation into proteins of the mucous membrane of the small intestine.

PMID- 1019323
TI  - [Acceleration of the aging process by ionizing radiation. 3. Behavior in cell
      culture of young, old and irradiated young rat kidney cells].

PMID- 1019324
TI  - [Effect of single doses of ionizing radiation on the mechanical properties of
      bone].

PMID- 1019325
TI  - Comparative studies in the glomerular filtration, the effective renal plasma-flow
      and ING by some chronic renal diseases.

PMID- 1019326
TI  - [Tomographic brain sctintigraphy in the diagnosis of intracranial space
      occupations (author's transl)].

PMID- 1019327
TI  - [Radioactive labelling of leukocytes with 113mIn and its possible clinical use in
      localization diagnosis on abscesses (author's transl)].

PMID- 1019328
TI  - [Two years of experiences with indium-labelled erythrocytes (author's transl)].

PMID- 1019329
TI  - [Roentgenological diagnosis of thromboembolia of the pulmonary artery. 1st
      communication: Method of examination (author's transl)].

PMID- 1019330
TI  - [Roentgenological diagnosis of thromboembolia of the pulmonary artery. 2nd
      communication: Roentgensemeiotics (author's transl)].

PMID- 1019331
TI  - [Two unsual complications of pancreatitis are reported which have a particular
      importance under preoperatie aspects (author's transl)].

PMID- 1019332
TI  - [On the problem of clinical place value of gastric mucosa prolapse into the
      duodenal bulb (author's transl)].

PMID- 1019333
TI  - [Possibilities of roentgenological recognition of movable gastric tumours and
      their prolapses into the duodenal bulb (author's transl)].

PMID- 1019334
TI  - [Percutaneous selective adrenovenography (indications, technique, results,
      complications) (author's transl)].

PMID- 1019335
TI  - Zonography in urology (author's transl).

PMID- 1019336
TI  - [Results of MacMurray's operation in patients with coxarthritis from the
      roentgenological view (author's transl)].

PMID- 1019337
TI  - [Skeletal participation in malignant hemoblastoma of the child (author's
      transl)].

PMID- 1019338
TI  - [Recurrence or effect of radiation therapy? Diagnostical problems in the
      judgement of the success of irradiation by means of lymphogram (author's
      transl)].

PMID- 1019339
TI  - [Comparative examinations with indirect thyroid lymphography and thyroid
      scitigraphy (author's transl)].

PMID- 1019340
TI  - [Halo sign--a criterion for the lymphographic diagnosis of metastases (author's
      transl)].

PMID- 1019341
TI  - [Actual problems of lymphography in uterus carcinoma (author transl)].

PMID- 1019342
TI  - [Recommended indications for  the use of lymphography in gynecology].

PMID- 1019343
TI  - [Tasks of the clinical radiation physicists in medical institutions of x-ray
      diagnostics, radiation therapy, and nuclear medicine (author's transl)].

PMID- 1019344
TI  - Nucleotide sequence analysis of coding and noncoding regions of human beta-globin
      mRNA.

PMID- 1019345
TI  - Mutation rates in globin genes: the genetic load and Haldane's dilemma.

PMID- 1019346
TI  - Structural studies on intact and deadenylylated rabbit globin mRNA.

PMID- 1019347
TI  - The relationship between hnRNA and mRNA.

PMID- 1019348
TI  - A comparison of nuclear and cytoplasmic viral RNAs synthesized early in
      productive infection with adenovirus 2.

PMID- 1019349
TI  - Biogenesis of silk fibroin mRNA: an example of very rapid processing?

PMID- 1019350
TI  - Visualization of the silk fibroin transcription unit and nascent silk fibroin
      molecules on polyribosomes of Bombyx mori.

PMID- 1019351
TI  - Distribution of hnRNA and mRNA sequences in nuclear ribonucleoprotein complexes.

PMID- 1019352
TI  - The structure of specific genes in chromatin.

PMID- 1019353
TI  - The structure of DNA in native chromatin as determined by ethidium bromide
      binding.

PMID- 1019354
TI  - Cellular skeletons and RNA messages.

PMID- 1019355
TI  - Nonhistone chromosomal proteins and histone gene transcription.

PMID- 1019356
TI  - Selective transcription of DNA mediated by nonhistone proteins.

PMID- 1019357
TI  - Structure and function of the RNAs of brome mosaic virus.

PMID- 1019358
TI  - Effect of 5'-terminal structures on the binding of ribopolymers to eukaryotic
      ribosomes.

PMID- 1019359
TI  - Protein and RNA synthesis in cultured muscle cells.

PMID- 1019360
TI  - mRNA structure and function.

PMID- 1019361
TI  - Transcribed oligonucleotide sequences in Hela cell hnRNA and mRNA.

PMID- 1019362
TI  - The relationship of the dispersion phase of chromocentric nuclei in the mitotic
      cycle to DNA synthesis.

PMID- 1019363
TI  - Ca++ controlled contraction-relaxation cycle in glycerinated amoeboid cells.

PMID- 1019364
TI  - Transsexualism and social attitudes. A case report.
AB  - After a brief review of the literature, a case of a male-to-female transsexual,
      with a 4-year follow-up, is presented. The etiological factors and some social
      responses to this pathology are discussed.

PMID- 1019365
TI  - EEG examination during delirium tremens.
AB  - In 30 male patients several EEG examinations could be carried out during delirium
      tremens (d.t.) or shortly thereafter. Most of the patients showed a normal EEG or
      changes which can be explained with regard to sedation through medication. 1
      patient showed generalized paroxysmal spike wave bursts. On account of
      experimental results, we may assume that a transitory cerebral excitibality
      change occures in d.t. This pathophysiological basis explains the normal EEGs and
      paroxysmal bursts during d.t. 4 cases showed passages of pronounced diffuse slow
      activity during d.t. partly accompanied by thythmic bilateral slow waves. These
      changes point to a complication of d.t. that occurs because of another disease
      which results in cerebral functional disturbances as in other organic psychoses.

PMID- 1019366
TI  - [Genetics of psychoses under a new aspect].
AB  - To analyze the biological pathways of the genetical activity in psychoses is
      growing more and more to an important goal. The research in this field should be
      started on the assumption of a multifactorial hereditary system controlling the
      somatic base of mental illness in a specific way as can be argued from twin and
      family studies. Screening the present data, there is strong evidence that the
      metabolism of affective psychoses is characterized by quantitative deviations
      only concerning the 5-hydroxytryptamine and norepinephrine turnover particularly.
      The biochemical findings in schizophrenic psychoses are suspicious for
      qualitative abnormities too. There are some indications of toxic products in the
      catecholamine metabolism and of antibodies against brain substances. All these
      disturbances could be caused by structural gene mutants or by mutations of the
      genetical regulatory system changing the sensitivity for the environmental
      stimulus. The simultaneous investigation of simple inherited serum groups is
      described as a useful tool for biological marking of the responsible genotypes.

PMID- 1019367
TI  - Delusional perception and delusional notion linked to a perception.
AB  - It is a neglected psychopathological fact that Schneider clearly differentiated
      the delusional notion linked to a perception ("wahrnehmungsgebundener
      Wahneinfall") from the delusional perception ("Wahnwahrnehmung"). When this
      distinction is not taken into account, it is very likely that the probability of
      a false positive rating for the delusional perception is increased. A possible
      practical aid to help operationalize the differential "diagnosis" between these
      two symptoms is offered. The section on "delusional" phenomena in Wing's present
      state examination is then discussed in the light of these distinctions.

PMID- 1019368
TI  - [Individual conditions of pharmacogenic confusion conditions. Comparison of
      amitriptyline and clozapine].
AB  - The literature was surveyed concerning the frequency and conditions for
      confusional states and deliria following Amitriptyline and Clozapine treatment,
      and certain discrepancies were noted. As a result a retrospective comparative
      investigation was carried out as to the frequency and the conditions for such
      events in a group of patients treated along the same lines. While our experience
      with Amitriptyline is not different from that reported by others, this does not
      seem to be the case with Clozapine. Confusional states and deliria are four times
      as frequent as the average reported in the literature; it is clear that they
      depend on conditions different from those of confusional states and deliria due
      to Amitriptyline; there is a slightly significant (p less than 0.05) correlation
      between the appearance of confusion and a temperature of over 37.5 degrees C. The
      anticholinergic properties of Amitriptyline and of Clozapine cannot explain the
      difference in frequency, nor the differing conditions for the appearance, of
      pharmacogenic confusional states and deliria with those two substances.

PMID- 1019369
TI  - Late suicide in former mental patients.
AB  - Results from the long-term follow-up studies "The Enquete of Lausanne" are
      presented, concerning the incidence of suicide in old age of former mental
      patients. Among 1,891 studied deaths, 107 (5.6%) known suicides occurred; the
      suicide rate for all diagnostic groups, except mental retardation (only females),
      being considerably higher than in the general Swiss population of the same age,
      especially for depressions, alcoholism, neurotic and psychopathic personality
      disorders.

PMID- 1019370
TI  - [New trends in modern industrial medicine].

PMID- 1019371
TI  - [Psychiatric epidemiological studies in industrial workers].

PMID- 1019372
TI  - [Program of primary prevention of coronary disease. I. Its incidence and risk
      among studied subjects].

PMID- 1019373
TI  - [Epidemiological studies of stomach and duodenal ulcer in workers of cooperating
      industrial works].

PMID- 1019374
TI  - [Occurrence of chronic non-specific diseases of the respiratory system in
      industrial workers in the light of epidemiological studies].

PMID- 1019375
TI  - [Autoacceptance and the type of interpersonal relations and the incidence of
      psychosomatic disorders in industrial workers with special reference to digestive
      system diseases].

PMID- 1019376
TI  - [Environmental factors and the incidence and extent of vibration disease. Results
      of complex studies of workers exposed to vibration and noise].

PMID- 1019377
TI  - [Toxic effects of mercury vapors in occupationally exposed workers. Environmental
      studies and clinical observations].

PMID- 1019378
TI  - [Dental system disorders in industrial workers studied by way of epidemiological
      methods].

PMID- 1019379
TI  - [Workers exposed to the action of fluorine and its compounds. Their effect on the
      state of health of industrial workers].

PMID- 1019380
TI  - [Effect of vinyl chloride on the state of health of industrial workers].

PMID- 1019381
TI  - [Thermal studies of work environment and its effect on some indices of the state
      of health in industrial workers].

PMID- 1019382
TI  - [Disease-caused absenteeism as a measure of relationship between the workers'
      subjective evaluation of their state of health and a complex of social factors in
      work environment].

PMID- 1019383
TI  - [Crohn's disease of the colon: anatomo-radiological correlations (author's
      transl)].
AB  - The epicritic revision of 74 histologically proved cases permits the authors to
      dwell on the radiological features of the diseased colon; their correlations with
      pathological findings and their differential diagnosis are discussed. A number of
      radiographs are presented as examples.

PMID- 1019384
TI  - [The clinical and radiological pictures of ulcerative colitis and Crohn's disease
      (author's transl)].
AB  - The differential diagnosis of ulcerative colitis and Crohn's disease is discussed
      in the light of the clinical and radiological pictures noted in 16 cases. A
      number of radiographs are presented.

PMID- 1019385
TI  - [The radiological picture of parietal modifications in the large intestine due to
      extrinsic masses (author's transl)].
AB  - About 600 cases of extrinsic masses in the large intestine have been examined by
      double contrast clysma; radiological signs of modifications in the intestinal
      walls are discussed with special reference to the distinction between
      compression, adherence, infiltration, etc. Some cases are reported.

PMID- 1019386
TI  - [Radiotherapy of giant-cell tumour of the vertebral column (author's transl)].
AB  - Five cases of successfully irradiated giant-cell tumours of the backbone, are
      reported; the problems of the radiotherapy of such tumours are discussed.

PMID- 1019387
TI  - [Complications observed in the radiosurgical management of cervical cancer
      (author's transl)].
AB  - Radiosurgical management, using 192Ir instead of radium, was carried out in 58
      cases of cervical cancer. The complications are described and discussed on
      relation to the dose employed.

PMID- 1019388
TI  - Changes in the bacterial cecal flora of mice infected with Trichuris muris
      (Schrank, 1788).
AB  - Cecal microorganisms of mice were categorized and enumerated weekly during the
      developmental cycle of infection with the whipworm, Trichuris muris. The cecal
      bacterial population consisted of Escherichia coli, Proteus spp, Acinetobacter
      lwoffi (Mima polymorpha), aerobic lactobacilli, staphylococci, enterococci, and
      anaerobes (bacteroides, streptococci, and lactobacilli) in control and T. muris
      infected mice. The aerobic lactobacilli and the anaerobes constituted the
      greatest number of organisms in both groups. In week three there was a decrease
      in the number of these organisms, and in week four fewer of these and of all
      other organisms in the worm-infected mice when compared to controls. The most
      significantly reduced bacterial counts were observed during the period of T.
      muris self-cure.

PMID- 1019389
TI  - The comparative susceptibility of male and female and of mature and immature cats
      to infection with sub-periodic Brugia malayi.

PMID- 1019390
TI  - [Ultrastructural aspects of nuclear differentiation during spermatogenesis in
      Myogryllus species (Orthoptera)].

PMID- 1019391
TI  - [Accumulation and loss of radionuclides in Gastropoda].

PMID- 1019392
TI  - [Methods of storing microbial population of the rumen in vitro].

PMID- 1019393
TI  - [Note concerning the recent cases of bovine tuberculosis (Myobacterium bovis) at
      the abattoir of Dakar].

PMID- 1019394
TI  - [Salmonella carrier state in Testudo sulcata, terrestial tortoise of Senegal].

PMID- 1019395
TI  - [Trial of cambendazole in 1-to-2-year-old Nigerian zebus].

PMID- 1019396
TI  - [Cenuriasis of small ruminants of central Africa. African cenuriasis of man and
      animals].

PMID- 1019397
TI  - [Description of Rhipicephalus camicasi n. sp. (Aearidae, Ixodida) of subdesert
      steppes of the plain of Afar].

PMID- 1019398
TI  - [Prospect of rationnal feeding of calves in Senegal and in sahelian zone].

PMID- 1019399
TI  - [N'Dama breed of cattle. Several zootechnic characteristics].

PMID- 1019400
TI  - [Estimation of the frequency of reno-vascular hypertension among unselected
      hypertensives (author's transl)].
AB  - In practical terms the frequency of renovascular hypertension can only be
      measured from groups of hospitalized hypertensives, in which severe forms and
      young subjects are over-represented, thus leading probably to an overestimate.
      Using a group of 1 009 consecutively hospitalized hypertensives, the frequency of
      renovascular hypertension was measured in 18 subgroups defined by sex, age (three
      classes) and blood pressure (three classes). For each subgroup the specific rate
      was then multiplied by the prevalence of the corresponding category in the
      population of unselected 20-64 years old hypertensives. This method led to the
      following conclusions: about 2% of the unselected hypertensives would be
      candidates for surgical correction of renovascular hypertension and 0.5% would be
      cured.

PMID- 1019401
TI  - Concordance of blood pressure in spouses.
AB  - It has been known for some years that familial aggregation of blood pressure
      levels occurs in adults. The question of how much of this aggregation can be
      attributed to genetical inheritance, and how much to a shared environment, is not
      yet resolved. Evidence of the influence of a common environment on blood pressure
      levels can be gained from examining spouses who are not genetically related. In a
      family study of blood pressure levels in children, 452 of the parents had had a
      single continuous marriage. These spouses had a small but significant association
      with respect to blood pressure, and this association varied with length of
      marriage. Different interpretations of this result are discussed in relation to
      those from longitudinal studies.

PMID- 1019402
TI  - [A method for studying social security records in epidemiology. Use in a study on
      the prognosis of chronic bronchitis (author's transl)].
AB  - A method is presented to study, in an epidemiological research, the social
      security records. This study is based upon records of workers affiliated to the
      french social security general system. To obtain data which may be compared, it
      was necessary to take the legislation as a basis; this legislation gives the data
      which must be in the records. A study of laws and rules has been done to find out
      these data in the medical record and in the administrative one. A questionnaire
      is presented. This basic questionnaire should be modified according to the
      precise objectives of each study and to the characteristics of the population
      sample. To illustrate this method, some results of a study of chronic bronchitis
      risk factors are presented in the second part. These results concern 950 men,
      born in France, aged 30 to 59 in 1960 an still alive in 1972. The study of the
      long reductions of the ability to work, happened from 1960 to 1971, confirm the
      disabling character of the group "chronic bronchitis, asthma, emphysema,
      respiratory insufficiency" which follows immediately cardiovascular and rheumatic
      diseases. The total number of beneficiaries of the social security is already
      very important and the whole population will be soon concerned. The use of the
      social security records as data source could give very interesting informations
      about morbidity. So, it is possible to study representative samples of the
      general population or of some particular groups, which has up to now, been done
      only in a slight extent.

PMID- 1019403
TI  - [Effects of halothane on pregnant rats].

PMID- 1019404
TI  - [Study of cerebral electric activity in patients anesthetised with enflurane].

PMID- 1019405
TI  - [Tobramycin in severely ill patients with various types of infection].

PMID- 1019406
TI  - [Prevention with macromolecular solutions of hypotensive states caused by
      preganglional sympathetic block].

PMID- 1019407
TI  - [Physiopathology and treatment of hemorrhagic shock].

PMID- 1019408
TI  - [Personal experience with intravenous regional anesthesia].

PMID- 1019409
TI  - [Anesthesia in opthalmology: cataract].

PMID- 1019410
TI  - [Use of dextran in the prevention of thromboemboliam in orthopedic and trauma
      surgery. Personal experience].

PMID- 1019411
TI  - [Local and cephalic tetanus. Personal experience in 4 cases].

PMID- 1019412
TI  - [Incomplete history of a clinical case (pathology of the voltaic arc syndrome)].

PMID- 1019413
TI  - [Attemps to explore the neurophysiological mechanism of the anticipatory
      responses triggered by the intake of water].

PMID- 1019414
TI  - [Behavioral effects of electrical stimulation of the lateral hypothalamus].

PMID- 1019415
TI  - [Reflections on neuro-endocrinological methods of observation].

PMID- 1019417
TI  - [Discussion: cerebral organization of interaction with the external environment].

PMID- 1019416
TI  - [The sensory basis of perception].

PMID- 1019418
TI  - [Graded complexity of the nervous system and models of its organization].

PMID- 1019419
TI  - [Models in the study of behavior in psychology].

PMID- 1019420
TI  - [The brain or the innate possibility].

PMID- 1019421
TI  - [Clinical and electroencephalographic study of hypercalcemic encephalopathy].

PMID- 1019422
TI  - [Repetitive muscle potentials in the normal subject].

PMID- 1019423
TI  - [Effect of local cooling on segmental reflexes].

PMID- 1019424
TI  - [Conditioning of the quadriceps myotatic arc by graduated activation of the
      soleus myotatic arc].

PMID- 1019425
TI  - [Topology of EEG coherence during spontaneous and induced states of arousal].

PMID- 1019426
TI  - [Statistical study of the electroencephalographic correlations between clinical
      and anatomical data. Application in 100 cases of cerebral abscess].

PMID- 1019427
TI  - [Electrophysiologic definition of sensory integration in the aphasic, (Evoked
      potentials, Slow potentials)].

PMID- 1019428
TI  - Errors in the measurement of total respiratory resistance and reactance by forced
      oscillations.
AB  - The total respiratory resistance determined by means of the forced oscillation
      technique during spontaneous breathing demonstrates a variability which may be
      due (1) to variations of the resistance itself, (2) to the superposition of rapid
      oscillatory and slow respiratory signals, (3) to the presence in the breathing
      signals of harmonics the frequency of which is the same as that of the
      oscillations. In the present study we investigate the importance of the third
      cause of variability, in a mechanical system in which causes 1 and 2 have been
      excluded. It is shown that the presence of high frequency components in breathing
      is an important source of error in the measurement of instantaneous resistance
      and reactance. The error is larger at higher frequency and amplitude of
      breathing, lower frequency and amplitude of forced oscillations, and in the
      presence of a high respiratory impedance. The error is likely to be negligible
      when the frequency of the forced oscillation is high (e.g. 30 Hz). At lower
      frequencies, theinfluence of harmonies in breathing can be corrected by
      calculating average resistance or reactance values over one or more respiratory
      cycles.

PMID- 1019429
TI  - Response to CO2 of intrapulmonary chemoreceptors in the emu.
AB  - We studied discharge frequencies of 12 intrapulmonary chemoreceptors in the
      paleopulmonic lung of an emu (Dromiceius novaechollandiae) during unidirectional,
      artificial ventilation when step changes and static CO2 concentrations were
      given. Discharge frequency in afferent neurons from the receptors increased as
      intrapulmonary CO2 decreased. The response of the receptors to various static
      intrapulmonary CO2 concentrations was similar to that previously demonstrated for
      the duck and chicken. The median sensitivity of the emu receptors at one-half
      maximal discharge was 4.6 imp-(sec-0.01 F1CO2)-1. Discharge frequencies altered
      phasically in nine of 12 receptors when step changes in CO2 of 3.3% at 1.6 Hz
      were given in the unidirectional gas stream while four of 12 modulated their
      discharge when the CO2 changes were as rapid as 3.2 Hz. Hence, some receptors can
      respond to rapid fluctuations in CO2 in their microencironment. We conclude that
      intrapulmonary chemoreceptors in the paleopulmonic lung of the emu exhibit
      similar characteristics to those in birds that possess varying amounts of
      neopulmonic parabronchi, such as the duck and chicken.

PMID- 1019430
TI  - Measurement of 'closing volume' initiated from functional residual capacity.
AB  - Comparison of the nitrogen method closing volume (CV) test, with oxygen
      inspiration initiated at residual volume (RV method) and functional residual
      capacity (FRC method), was made in 91 seated normal subjects. For RV and FRC
      methods, respectively CV%VC (mean+/-SD) was 14.4% (+/-6.2) and 17.5%(+/-7.5)
      (P=0.005); slope of Phase III of CV trace was 0.99% N2/1 (+/-0.76) and 1.66%
      N2/1(+/-1.07) (P=0.005); size of cardiogenic oscillations was 1.05% N2(+/-0.42)
      and 1.21% N2(+/-0.40) (P=0.001). These data confirm earlier predictions, based on
      a calculated increased lung top to bottom N2 gradient in the FRC method. Support
      for this mechanism was obtained in 5 additional normal subjects in whom the
      increased CV%VC, slope of Phase III and size of cardiogenic oscillations with the
      FRC method were eliminated when the top-to-bottom N2 gradient was reduced by
      breathing a reduced FIN2. Measurements made using the classical RV method cannot
      be directly compared to those using the FRC method.

PMID- 1019431
TI  - Hypoxia and carbon dioxide as separate and interactive depressants of
      ventilation.
AB  - The respiratory frequency, tidal volume and ventilization responses of 20
      conscious cats to hypoxia, at controlled levels of alveolar CO2, revealed a
      characteristic steady state response in the majority of animals which indicated a
      negative interaction of stimuli on tidal volume and minute volume of ventilation,
      but a positive interaction on frequency. Another series of studies, conducted on
      seven conscious cats, sought to identify hypoxic response thresholds and
      depression thresholds, by determining responses over a wide range of hypoxic
      stimulus intensities, and at different controlled alveolar PCO2. Response
      threshold was at about 65 torr PAO2. Under eucapnic conditions, ventilation began
      to fail at PAO2 about 30 torr due to failure of tidal volume. The frequency
      continued to increase even in the lowest range of PAO2. With hypocapnia no
      failure of ventilation, frequency, or tidal volume was seen even at the lowest
      PAO2, but with hypercapnia, the tidal volume began to fail at PAO2 about 50 torr.
      The minute volume however, continued to increase into the lowest range of PAO2,
      because the frequency continued to respond at a rate greater than the tidal
      volume was failing. The results are discussed in terms of interactive depression
      manifest through the coupled responses of peripheral and central mechanisms.

PMID- 1019432
TI  - Amount and rates of CO2 storage in lung tissue.
AB  - The slope of the lung tissue CO2 dissociation curve and the rate of storage of
      CO2 in the lung tissue were studied at 22 degrees C and at 37 degrees C in 21
      isolated, bloodless dog lungs with a total of 465 separate observations. Results
      at the two temperatures were similar. The slope of the tissue dissociation curve
      of lung tissue at a PCO2 of 40 torr was approximately 0.3 ml CO2 X 100 g wet
      tissue-1 X torr-1. Normally, this storage was 90% complete in about 5 seconds.
      After carbonic anhydrase inhibition by acetazolamide, the total storage capacity
      was unchanged, but the rate at which storage occurred decreased significantly, so
      that it took about 25 seconds for 90% of the storage to be completed.

PMID- 1019433
TI  - Organisation of the auditory receptor.

PMID- 1019434
TI  - [Ultrastructure of the pathologic organ of Corti].

PMID- 1019435
TI  - Problems of cochlear microphonic recording in man.

PMID- 1019436
TI  - Electrophysiological study of the normal and pathological human cochlea. I.
      Presynaptic potentials.

PMID- 1019437
TI  - Electrophysiological study of the normal and pathological human cochlea. II.
      Neural responses.

PMID- 1019438
TI  - Trans-tympanic electrocochleography in the investigation of retro-cochlear
      disorders.

PMID- 1019439
TI  - Principles in modeling biological systems.

PMID- 1019440
TI  - Modeling action potentials.

PMID- 1019441
TI  - [Maturation of the auditory system].

PMID- 1019442
TI  - [Electric manifestations of function of the auditory pathway as a whole in man].

PMID- 1019443
TI  - Clinical use of auditory evoked potentials.

PMID- 1019444
TI  - Properties of auditory brainstem evoked responses.

PMID- 1019445
TI  - Contingent negative variations and differential hearing thresholds.

PMID- 1019446
TI  - Electrophysiological measures of auditory perception.

PMID- 1019447
TI  - Electrophysiological data and psychophysical measurement.

PMID- 1019448
TI  - [The role of university environment in the development of student's personality].

PMID- 1019449
TI  - [Hemolytic dyserythropoiesis in myelopathies].

PMID- 1019450
TI  - [Clinical significance of the negative U wave].

PMID- 1019451
TI  - [Clinical, hematological and biochemical studies on 140 cases of pregnancy
      anemias].

PMID- 1019452
TI  - [Left ventricular systolic dynamics in chronic cor pulmonale].

PMID- 1019453
TI  - [Indications for biliodigestive anastomosis in the treatment of common bile duct
      calculi].

PMID- 1019454
TI  - Some aspects of the rarely encountered aseptic meningitis in the epidermoid cysts
      evolution.

PMID- 1019455
TI  - [Surgical treatment of duodenal ulcer using vagotomy. Our experience in 100
      cases].

PMID- 1019456
TI  - [Fractures of the radius accompanied by open inferior radioulnar dislocation].

PMID- 1019457
TI  - [Beta hemolytic streptococci group G in skin infections].

PMID- 1019458
TI  - [Study of a leptospirosis focus with L. grippotyphosa in a Subcarpathian zone.
      III. Postepizooto-epidemic evolution of the focus].

PMID- 1019459
TI  - [Comparative values of various psychophysiological and biochemical indicators for
      the assessment of stress and adaptation of the human body to automatized labor].

PMID- 1019460
TI  - [Study of environmental pollution with pesticides used in agriculture].

PMID- 1019461
TI  - [The Imerslund syndrome].

PMID- 1019462
TI  - [Malleo-meniscal ligaments. I].

PMID- 1019463
TI  - Influence of lithium carbonate on the nucleic acid concentrations in the guinea
      pig brain and liver.

PMID- 1019464
TI  - [Changes of the gingival mucosa under dental prostheses made of stainless
      alloys].

PMID- 1019465
TI  - [Studies on the eruption of permanent teeth. I].

PMID- 1019466
TI  - [Organization of medical care for the elderly].

PMID- 1019467
TI  - [Derivatives of 2-thion-thiazolid-4-one with an antimicrobial effect].

PMID- 1019468
TI  - [Criteria for the use of an unique technic of complement fixation in the
      serodiagnosis of infections (bacterial, fungal, parasitic) and in the study of
      immunological conditions].

PMID- 1019469
TI  - [Computer program for the irradiation of the urinary bladder].

PMID- 1019470
TI  - [Value of uterine curettage-biopsy in perimenopausal hemorrhage].

PMID- 1019471
TI  - [The Stein-Leventhal syndrome and primary amenorrhea].

PMID- 1019472
TI  - [Granulomatous pyelonephrites].

PMID- 1019473
TI  - [Comments on a case of partial congenital paralysis].

PMID- 1019474
TI  - [Prognostic significance of intraventricular conduction disorders in acute
      myocardial infarct].

PMID- 1019475
TI  - [Unrecognized complications of oral antipoliomyelitis vaccination].

PMID- 1019476
TI  - [Hallux valgus. Late results with Lelievre's operation].

PMID- 1019477
TI  - [Average arterial pressure: normal and stimulated values].

PMID- 1019478
TI  - [Summary of activity of the hygiene laboratories of the Ernest Malvoz Provincial
      Institute in 1975].

PMID- 1019479
TI  - [Genetics. Importance of a semi-systematic hematologic examination among certain
      minority immigrants].

PMID- 1019480
TI  - [Reparation for body injury: education of experts].

PMID- 1019481
TI  - [Prognosis for acute renal insufficiencies treated with an artificial kidney].

PMID- 1019482
TI  - [Spastic bronchitis in Israel].

PMID- 1019483
TI  - [Reflections on hospital programming].

PMID- 1019484
TI  - [The clinical picture of cerebral senility].

PMID- 1019485
TI  - [Anatomo-pathologic aspects of cerebral involution in senescence].

PMID- 1019486
TI  - [Differential diagnosis of the psycho-organic syndrome].

PMID- 1019487
TI  - [Drugs for chronic cerebral insufficiency].

PMID- 1019488
TI  - [Therapeutic approach to the psycho-organic syndrome].

PMID- 1019489
TI  - [Health protection of hospital personnel].

PMID- 1019490
TI  - [Cleanliness and disinfection of the environment].

PMID- 1019491
TI  - [Cleanliness and disinfection of the environment].

PMID- 1019492
TI  - [Control of hospital infections and health education].

PMID- 1019493
TI  - [Antibiotic policy].

PMID- 1019494
TI  - [Control of disease carriers].

PMID- 1019495
TI  - [Control of professional hazards].

PMID- 1019496
TI  - [Microbiology of obstetrical infection].

PMID- 1019497
TI  - [Methods of fighting and preventing hospital infections].

PMID- 1019498
TI  - [Technics of restoration and intravenous administration].

PMID- 1019499
TI  - [Periodical health examinations as a means of protecting the health personnel. A
      model of medical records].

PMID- 1019500
TI  - [Profesional risk and health protection of blood-bank personnel].

PMID- 1019501
TI  - [Antituberculosis protection in the hospital].

PMID- 1019502
TI  - [Antiseptics and disinfectants].

PMID- 1019503
TI  - [Design of a surgical unit].

PMID- 1019504
TI  - [Pathogens responsible for hospital infections].

PMID- 1019505
TI  - [Use of antiseptics and disinfectants in the Residencia Sanitaria Vergen del
      Camine].

PMID- 1019506
TI  - [Survey on hand washing among health personnel].

PMID- 1019507
TI  - [Hospital sanitation].

PMID- 1019508
TI  - [Concept and evaluation of antiseptics and disinfectants].

PMID- 1019509
TI  - [Sanitary-hygienic needs for medicine carts].

PMID- 1019510
TI  - [Norms for therapy].

PMID- 1019511
TI  - [Evaluation of obstetric infection].

PMID- 1019512
TI  - [Control of adverse drug reaction in a hospital environment].

PMID- 1019513
TI  - [Control of antibiotic therapy in the Clinica Universitaria].

PMID- 1019514
TI  - [Control of the quality of antibiotics and their i/v mixtures in large volume
      solutions].

PMID- 1019515
TI  - [Therapeutic control in the hospitals].

PMID- 1019516
TI  - [Principles of hospital antibiotic policy].

PMID- 1019517
TI  - [Iatrogenic adverse effects of hemotherapy].

PMID- 1019518
TI  - [Noise in the hospital].

PMID- 1019519
TI  - [Control of postoperative fever as an index of cross infection].

PMID- 1019520
TI  - [Hospital sanitation].

PMID- 1019521
TI  - [The risk of hospitalization].

PMID- 1019522
TI  - [Hospitalary microbiology].

PMID- 1019523
TI  - [Use of antibiotics in the hospital].

PMID- 1019524
TI  - [The value and current status of hospital hygiene in Europe].

PMID- 1019525
TI  - [Study of the Mantoux reaction in a hospital institution].

PMID- 1019526
TI  - [Study on the immunological rubella level among female personnel in a hospital].

PMID- 1019527
TI  - [Nystagmus of cervical origin. Physiology, research, results, and clinical
      importance].

PMID- 1019528
TI  - [Vertebro-basilar circulatory insufficiency. Apropos of 85 confirmed cases].

PMID- 1019529
TI  - [Cataract evolving in the course of a complex syndrome of progressive myositis
      ossificans with symptoms of Klippel-Feil syndrome].

PMID- 1019530
TI  - [Hypoacusis in pigmentary retinopathy].

PMID- 1019531
TI  - [Opto-chiasmatic arachnoiditis. Prognostic criteria and surgical indication].

PMID- 1019532
TI  - [Non-verbal vocal expression in aphasics].

PMID- 1019533
TI  - [Encephalitis of the brain stem in children].

PMID- 1019534
TI  - [Syphilitic retinal vasculitis].

PMID- 1019535
TI  - Human rabies. II. Serological studies and intra-vitam virus isolation.

PMID- 1019536
TI  - Infectivity for mice of cercariae, schistosomules and intermediate forms of
      Schistosoma mansoni, obtained in vitro.

PMID- 1019537
TI  - Evaluation of Borda & Pellegrino's technique in the quantitative diagnosis of
      hookworm infections.

PMID- 1019538
TI  - The crowding effect in Schistosoma mansoni infection of hamsters: influence on
      worm size.

PMID- 1019539
TI  - Experimental chemotherapy of schistosomiasis mansoni. XIV. Active derivatives of
      aminoethanephosphorothioate, disulfide, and isothiourea.

PMID- 1019540
TI  - Preliminary studies on the antischistosomal activity of topically applied
      oxamniquine.

PMID- 1019541
TI  - Autofluorescent hepatic particles in HB ag sero-positive patients (preliminary
      report).

PMID- 1019542
TI  - A turbidimetric assay method for studying antibody-induced lysis of hapten-coated
      erythrocytes.
AB  - A method is described, based on the application of trubidimetry for study of
      antibody-mediated complement-dependent lysis of hapten-coated erythrocytes. The
      procedure is simple, reliable and sensitive. Time-rate studies over the entire
      range of interaction between the reactants are possible, with a minimal
      consumption of materials and time. The method also gives the possibility of
      adding substances to the reaction mixture, even at high concentrations, without
      introducing errors by multiple handling and washing.

PMID- 1019543
TI  - Ultrastructural changes in HEp-2 cells treated with staphylococcal alpha-toxin.
AB  - The effect of highly purified staphylococcal alpha-toxin on HEp-2 neoplastic
      cells growing in culture was studied by electron microscopy. In addition to some
      nuclear modifications, the most significant morphological changes were in
      mitochondrial structure, alpha-toxin seems to induce a defined sequence of
      changes in mitochondrial configuration which can be summarized as an earlier
      phase of 'condensation' of mitochondrial structure and a later phase of
      mitochondrial swelling with an intermediate 'transitional' configuration. The
      significance of these findings is discussed in the light of the present state of
      knowledge of the biological characteristics of staphylococcal alpha-toxin.

PMID- 1019544
TI  - The capnogram in the study of chronic obstructive lung disease.
AB  - The purpose of this study is: 1) to emphasize the importance of the capnogram in
      the investigation of ventilatory disorders of the obstructive type; 2) to propose
      a numerical parameter representative of the capnogram; 3) to ascertain, by means
      of this parameter, possible correlations between capnogram changes and other
      tests of lung function. This parameter enables a quantitative criterion to be
      substituted for a descriptive one in assessment of the capnogram; The study
      covered 245 patients with chronic obstructive lung disease; We observed that as
      the capnographic tracing becomes more and more pathological, the lung function
      tests show progressive deterioration.

PMID- 1019545
TI  - The role of nuclear medicine procedures in clinical nephrology: current clinical
      status and future directions.
AB  - This review discusses the use of radionuclides in nephrology. Radioactive
      materials may be used for measurements of renal function (glomerular filtration
      rate, renal plasma flow) and for renal imaging. The compounds of choice for GFR
      and RPF measurements are 125I iothalamate and 125I orthoiodohippurate,
      respectively. Neither is the ideal agent since the radiolabeled yields a high
      radiation dose. No single agent has emerged as the best for renal imaging,
      however, a great many have been introduced in the last few years and their
      relative merits are reviewed here. The rationale for use of radionuclides in
      nephrology is based on an awareness of the pathophysiology of the disease process
      and of the physiologic handling of the radiopharmaceutical used in the diagnostic
      study.

PMID- 1019546
TI  - Trace elements in biological systems: nuclear techniques app.
AB  - Nuclear techniques are very useful in the simultaneous determination of many
      trace elements in biological samples; the sensitivity depends on the method and
      on the elements in study and in many cases is better than 0;1 ppm. Proton-induced
      X-ray fluorescence and alpha-particle elastic diffusion techniques are described;
      the methods of sample preparation, the sensitivity obtained and some experimental
      results are included.

PMID- 1019547
TI  - Deadtime correcton in high count rate quantitative dynamic studies with computer
      assisted Anger-cameras.
AB  - The use of tracers with high radioactivity in rapid dynamic quantitative studies
      (such as radioisotope angiocardiography), performed by the Anger-camera and data
      processor, makes it possible to obtain a high counting ratemfor correct
      interpretation of the results of the analysis of activity/time curves in regions
      of interest, the authors determined, under different working conditions, the
      deadtimes of two Anger-cameras (Pho-gamma HP and Radicamera II), both connected
      to a data-processing system (Med-II). The problems inherent in this determination
      are analyzed and discussed. A computer program for curve correction was written
      and some examples of applications of it are presented, including an experiment to
      test the accuracy of the correction.

PMID- 1019548
TI  - [Control of genetic disease: current possibilities and prospects in the sphere of
      a research unit for diagnosis and prevention of hereditary and chromosomal
      diseases].

PMID- 1019549
TI  - [Infertility: proposal of a behavior model in the light of cytogenetic studies].

PMID- 1019550
TI  - [Ascites and hydrothorax due to endogenous hyperstimulation of H.C.G. in a case
      of hydatidiform mole destruens with secondary irreversible kidney insufficiency
      due to disseminated intravascular coagulation].

PMID- 1019551
TI  - [Toxoplasmosis and pregnancy].

PMID- 1019552
TI  - [Comparison between the diagnostic and prognostic value of urinary estriol in
      relation to the estriol/creatinine ratio in high risk pregnancies].

PMID- 1019553
TI  - [Fetal and maternal complications due to the use of electrodes applied to the
      fetus].

PMID- 1019554
TI  - [Obstetric future of patients who have undergone surgery of the uterine cervix
      and vagina during the reproductive age period].

PMID- 1019555
TI  - [2 cases of benign ovarian syndrome accompanied by hydrothorax (pseudo-syndrome
      of Meigs'?)].

PMID- 1019556
TI  - [Perinatal mortality in Spain 1951-1970].

PMID- 1019557
TI  - [Small outbreak of cholera in the Province of Orense].

PMID- 1019558
TI  - [Parasitological and clinical study of 2 cases of human myiasis caused by Oestrus
      ovis].

PMID- 1019559
TI  - [Rubella, measles and mumps virus antibodies in children of Sao Paulo, Brazil].

PMID- 1019560
TI  - [Classification of subjects in the tuberculin test: application of a statistical
      model when the frequency distribution of the induration is a mixture of normal
      components].

PMID- 1019561
TI  - [Epidemiological aspects of pulmonary tuberculosis in the provinces of Botucato,
      Conchas, Sao Manuel and Avare, State of Sao Paulo, Brazil from 1963 to 1972].

PMID- 1019562
TI  - [Importance of small industrial factories on the problem of industrial accidents
      in Sao Paulo].

PMID- 1019563
TI  - [Urine output of phenol in industrial workers exposed to benzene in the shoe
      industry].

PMID- 1019564
TI  - [Organization of state public health laboratories in Brazil].

PMID- 1019565
TI  - [Prevalence of parasitic diseases by Toxocara canis in dogs, and the finding of
      eggs of Toxocara species in the soil of public places in the urban area of
      Londrina, State of Parana, Brazil].

PMID- 1019566
TI  - [Characteristics of morbidity of the population treated at the health-school
      center of Sao Jose do Rio Petro, Sao Paulo, (Brazil)-1974].

PMID- 1019567
TI  - [The teaching of social sciences in professional schools in the health field in
      Brazil].

PMID- 1019568
TI  - [Nutritional ecology of "wild" domestic cats (Felis silvestris f. catus L.) in
      the Canton of Bern (Switzerland)].

PMID- 1019569
TI  - Alectopsylla unisetosa nov. gen., nov. spec. (Siphonaptera, Ischnopsyllidae) from
      Argentina.

PMID- 1019570
TI  - [Nematodes of stygorhitral waters in the Austrian Alps].

PMID- 1019571
TI  - Mechanism of isotonic fluid transport in the intestinal tract and kidney tubules.

PMID- 1019572
TI  - Effect of acetazolamide on glomerular balance and renal metabolic rate.
AB  - Glomerulotubular balance, defined as proportionality between filtered and
      reabsorbed sodium during inhibition of sodium reabsorption in the thick ascending
      limb of Henle's loop (diluting segment), was examined in anaesthetized dogs by
      gradual reduction of renal arterial pressure. In control experiments,
      glomerulotubular balance applied over the whole rante of glomerular filtration
      rate (GFR) examined but was absent after acetazolamide administration (30
      mg/kg/body wt) at GFR above 50% of control. Hence, the inhibitory effect of
      acetazolamide varied with GFR. At control GFR, acetazolamide reduced tubular
      sodium reabsorption by 32 +/- 2% chloride reabsorption by 34 +/- 3%, and
      bicarbonate reabsorption by 52 +/- 2%; no significant effect was observed at GFR
      below 50% of control. For each bicarbonate ion, three sodium ions and two
      chloride ions were inhibited. Measurements of renal oxygen consumption and heat
      accumulation rates showed that acetazolamide did not reduce renal metabolic rate
      significantly. It is proposed that energy-requiring hydrogen ion secretion occurs
      at unchanges rate during variations in GFR but that back leakage of hydrogen ions
      varies with bicarbonate concentration in tubular fluid. Net secretion of hydrogen
      ions is associated with bicarbonate transport into the intercellular space and is
      linked with sodium reabsorption. The concentration difference of bicarbonate
      salts over the tight junction (zonula occludens), which is much less permeable to
      bicarbonate than to sodium chloride, provides the osmotic force for reabsorption
      of water and sodium chloride from the tubular lumen into the intercellular space.
      Glomerulotubular balance is mediated by variations in filtered amounts of
      bicarbonate.

PMID- 1019573
TI  - Blood pressure measurement of all five fingers by strain gauge plethysmography.
AB  - The aim of the present paper was to study the methodological problems involved in
      measuring systolic blood pressure in all five fingers by the strain gauge
      technique. In 24 normal subjects, blood pressure at the proximal phalanx of
      finger I and both at the proximal and the intermediate phalanx of the other
      fingers was measured using a 24-mm-wide cuff. Blood pressure at the proximal
      phalanx was higher than that at the intermediate phalanx in all fingers except
      finger V. The difference of blood pressure values corresponded well with
      circumference of the finger. In 15 normal subjects, blood pressure at the
      proximal phalanx was compared in fingers I, III, IV, and V, using 16, 20, 24 and
      24 mm wide cuffs. Finger blood pressure was closest to arm systolic blood
      pressure when a 24-mm or 27-mm-wide cuff was used in fingers I, III, and IV, and
      with a 20-mm-wide cuff in finger V. As the standard deviation of the mean values
      was larter with the 27-mm-wide cuff than with the 24-mm-wide cuff, the 24-mm-wide
      cuff was considered to be most suitable for clinical use in fingers I, II, III,
      and IV. By using the 20-mm-wide cuff in finger V and the 24-mm-wide cuff in the
      other fingers, normal value of finger blood pressure was determined for both
      proximal and intermediate phalanxes.

PMID- 1019574
TI  - Intra-arterial infusion of prostaglandin E1 in normal subjects and patients with
      peripheral arterial disease.
AB  - Acute vasodilatation was produced by infusion of prostaglandin E1 (PGE1) in the
      femoral artery in 6 patients with occlusive arterial disease of the legs and in 3
      normal subjects. The effect on blood flow and on blood pressure was measured at
      different segments of the leg with the strain gauge technique, isotope clearance
      technique, and photoelectric technique. Skin temperature was measured at
      different levels by using thermocouples. The blood pressure on the legs decreased
      at all segments during vasodilatation as well in patients as in controls. The
      blood flow increased in all segments in normal controls. In patients the blood
      flow increased proximally in the legs. Distally, however, no increase could be
      demonstrated. As a good effect of PGE1, on ischaemic rest pains has been
      reported, mechanisms other than vasodilatation should probably be considered.

PMID- 1019575
TI  - Salicylate- and aspirin-induced uncoupling of oxidative phosphorylation in
      mitochondria isolated from the mucosal membrane of the stomach.
AB  - The hypothesis that the damaging effect on the stomach mucosa of salicylic acid
      and its derivatives is ascribable to an uncoupling of oxidative phosphorylation
      has been investigated by testing of mitochondria isolated from the corpus gland
      area of mini-pig gastric mucosa. Mitochondria, influenced by salicylate or
      acetylsalicylate (0.7-5.6 mmol/l), demonstrated increased respiration rate,
      decreased respiratory control ratio, and decreased P/O ratio when tested in
      vitro. Uncoupling of oxidative phosphorylation occurred at a salicylate
      concentration between 3.5 and 5.6 mmol/l.

PMID- 1019576
TI  - Influence of hypoxia and hyperoxia on subcutaneous adipose tissue blood flow in
      man.
AB  - Subcutaneous adipose tissue blood flow (ATBF) was measured by the 133Xe washout
      method in normal men breathing oxygen at partial pressures from 0.1 to 2
      atmospheres. Breathing oxygen at partial pressures of 0.1 and 1 atm. increased
      and reduced ATBF by 56% and 26%, respectively as compared to air breathing. These
      effects were highly significant. Breathing of oxygen at 2 atm. partial pressure
      had no consistent effect on ATBF, although considerable changes--positive or
      negative--could been seen in some experiments. Oxygen-breathing at 1 atm. partial
      pressure is associated with a slight hyperventilation and fall in PACO2. This was
      shown to be without importance for the effect of oxygen on adipose tissue blood
      flow.

PMID- 1019577
TI  - The metabolism in man of intravenously injected iodine-labelled trascobalamin I
      not saturated with cobalamin.
AB  - Transcobalamin I not saturated with cobalamin was purified. After iodine
      labelling, a fraction of approximately 0.6 retained its cobalamin-binding
      capacity. Iodinated protein was used for turnover studies in three healthy
      subjects. The plasma curves obtained were identical to those of iodinated
      transcobalamin I saturated with cyanocobalamin. The cobalamin-binding capacity of
      the iodinated protein was determined on microcolumns containing insolubilized
      cobalamin. The binding capacity decreased rapidly, only 50% of the initial
      unsaturated cobalamin-binding capacity remaining after 0.2 to 0.3 days. It is
      concluded that the turnover of transcobalamin I not saturated with cobalamin does
      not differ from the turnover of transcobalamin I saturated with cyanocobalamin,
      and that transcobalamin I saturated with cobalamin in vivo is metabolized at the
      same rate as is transcobalamin I saturated with cyanocobalamin in vitro.

PMID- 1019578
TI  - An automated micromethod for the determination of serum iron.
AB  - A rapid, automated micromethod is reported for the determination of serum iron
      with the AutoAnalyzer I system. 95 mul of serum is required, and the analysis is
      run at a speed of 50 samples per hour. Copper does not interfere with the iron
      analysis. Total iron-binding capacity can be measured with this method. Reference
      values for the serum iron concentration in children 6 weeks to 6 years old are
      presented.

PMID- 1019579
TI  - The estimated daily loss of trace elements from normal skin by desquamation.
AB  - The content of 21 elements (As, Au, Br, Ca, Cd, Co, Cr, Cs, Cu, Fe, Hg, K, La,
      Mo, P, Rb, Sb, Sc, Se, W and Zn) in normal epidermis has been determined with the
      aid of neutron activation analysis. The dermal loss of these elements via
      desquamation has been calculated in view of its possible importance in balance
      studies. For the bulk elements Ca, K and P, the calculated daily loss is
      considered to be negligible. For some of the trace elements, however, the loss
      may be appreciable. The daily loss of Fe by desquamation may be as much as one
      fourth of the daily urinary iron excretion; the corresponding fraction for Co,
      Cu, and Zn is one tenth.

PMID- 1019580
TI  - Positional fatty acid composition in total and acetone-precipitated amniotic
      fluid lecithin.
AB  - The fatty acid composition of lecithin has been determined separately at the 1-
      and 2-position in 22 samples of amniotic fluid. Palmitic acid (16:0) was the main
      fatty acid present at both carbon atom positions throughout the last trimester.
      Myristic acid (14:0) was present in very small amounts only. There was no
      evidence of 1-palmitoyl/2-myristoyl lecithin being present in more than trace
      amounts before 35 weeks of gestation. The positional specificity of the
      methylation pathway is therefore doubtful. Acetone precipitation of lecithin did
      not alter the observed fatty acid composition at either position, indicating that
      this procedure precipitates the different lecithin subspecies in equal
      proportion, without any preference for disaturated species. This method therefore
      fails to isolate a lecithin fraction with a specific fatty acid composition.

PMID- 1019581
TI  - Amniotic fluid palmitic acid concentrations and prediction of fetal lung
      maturity.
AB  - A method for rapid determination of total esterified palmitic acid concentration
      (TEPAC) in amniotic fluid is described. The correlation coefficient between the
      TEPAC and the lecithin concentration was 0.93 in 123 samples of amniotic fluid
      obtained during the last trimester. The respiratory distress syndrome (RDS)
      occurred in 73% of the cases studied with TEPAC less than mmol/l in predelivery
      samples. The RDS was not observed with higher concentrations except in cases of
      maternal diabetes mellitus. The predictive value of total esterified fatty acid
      studies was confirmed to the concentration of palmitic acid recorded, and no
      specific fatty acid distributions or ratios were reliable in identifying RDS or
      estimating gestational age.

PMID- 1019582
TI  - The effect of lysolecithin on the release of oleate from triolein by human post
      heparin lipase.

PMID- 1019583
TI  - Assay of pyroglutamate hydrolase (5-oxoprolinase) in tissue homogenates.

PMID- 1019584
TI  - Fibrinolytic activity in wound secretions.
AB  - Debrisan, a highly hydrophilic dextran polymer, was previously shown to be
      effective in cleaning infected wounds. The dry beads remove wound secretions from
      the wound surface under gel formation. The gel can then be analysed. A high
      fibrinolycic activity on fibrin plates and high levels of fibrin/fibrinogen
      degradation products were found in the secretions from 12 wounds. Low of
      plasminogen, antithrombin III and the absence of coagulable fribinogen also
      indicated a high fibrinolytic activity. A higher fibrinolytic activity on heated
      than on unheated fibrin plates, and the insignificant effect of local application
      of EACA suggest the presence of other proteolytic enzymes than plasmin.

PMID- 1019585
TI  - Innervation of human axillary sweat glands. Histochemical and electron
      microscopic study of hyperhidrotic and normal subjects.
AB  - Adrenergic nerves were demonstrated by formaldehyde-induced fluorescence and
      cholinergic nerves using thiocholine techniques to demonstrate
      acetylcholinesterase activities at the light and electron microscopic levels. The
      specimens were taken during surgery from the axillae of hyperhidrotic patients
      and normal voluntary controls. No fluorescent nerves were found around eccrine or
      apocrine sweat glands in hyperhidrotic or normally sweating axillae. Both eccrine
      and apocrine sweat glands exhibited a nerve network showing acetylcholinesterase
      activity. There was no marked difference in the innervation patterns or in the
      intensity of the acetylcholinesterase reaction of the nerves in the hyperhidrotic
      patients or normal subjects. Ultrastructurally the acetylcholinesterase-positive
      nerves were seen in the vicinity of both eccrine and apocrine glands, but these
      nerves were outside the basement membrane.

PMID- 1019586
TI  - Tracheal reconstruction with perichondrial grafts.
AB  - Since 1972 a series of experiments (Skoog, Ohlsen & Sohn, 1972; 1975; Ohlsen,
      1976) has been performed to elucidate the potential of perichondrial grafts to
      generate cartilage. In 1974 Sohn & Ohlsen demonstrated in rabbits that tracheal
      cartilage could be reconstructed from free perichondrial grafts.  As these
      studies were carried out with an intact tracheal mucosa a series of experiments
      was conducted in rabbits, and reported in this paper, in which a tracheal section
      containing two cartiliages and the covering mucous membrane was removed and
      replaced with a free perichondrial graft taken from the ear. New cartilege formed
      in all animals.  The reconstructed portion of trachea was partly covered by
      ciliated cells of normal appearance, partly by low epithelium with microvilli. 
      These latter areas were mainly within the central parts of the regenerated
      mucosa. The use of perichondrial grafts for tracheal reconstruction was also
      studied in two series of dogs. In four dogs a tracheal section, consisting of two
      comlete cartilages with the covering mucosa, was completely removed.  The
      circumferential defect was reconstructed by free perichondrial grafats from rib
      cartilage.  They were placed on two fascial flaps which had been raised from the
      adjacent muscles, rotated into the defect and sutured for complete coverage.
      Regeneration of cartilage occurred in all dogs, producing a biologic framework. 
      The lining of the reconstructed tracheal section was completely restored by
      epithelialization from the surrounding mucosa.  Low epithelial cells were
      successively replaced by columnar ciliated cells typical of the respiratory
      tract. The morphological development of the regenerated epithelium was
      demonstrated by electron microscopy. The regenerated mucosa exhibited normal
      function by passing mucus across the reconstructed area. This was recorded by
      filming at low speed using Cardio-green as indicator. All the animals of this
      series developed tracheal stenosis within the reconstructed portion. Another
      experiment was therefore carried out in which four dogs were subjected to the
      same operative procedure. Postoperatively, however, during the phase of healing,
      a silicon tube was inserted and left in situ to maintain expansion of the
      reconstructed portion. By this means stenosis could be prevented with good
      regeneration of the mucosal lining.

PMID- 1019587
TI  - Carcinoma of the external ear.
AB  - An analysis of 246 operated patients with 260 carcinomas of the external ears
      from the periods 1949-57 and 1962-67 is presented. Carcinoma of the external ear
      occurs in Denmark with a frequency of 1.2 cases per 100 000 inhabitants and
      constitutes approximately 6% of all skin cancers. In the present material 67% of
      the tumours were squamous-cell carcinomas and 30% were basal-cell carcinomas.
      These forms of tumours were most frequent in elderly men who have had outdoor
      employment. Half of these tumours were sited on the helix and lobe, while one
      quarter, respectively, were sited medially and laterally. 15% of the squamous
      cell carcinomas recurred, 3% of the these with metastases of the regional lymph
      nodes. Of the basal-cell carcinomas 18% recurred but with no metastases of the
      regional lymph nodes. The frequency of recurrence did not depend on the site of
      the tumour on the ear, but it did increase with increasing tumour size. The 5
      year survival rate without recurrence was 56% +/- 4% for the squamous-cell
      carcinomas, and for the basal-cell carcinomas 59% +/- 6.5%. It is concluded that
      surgical treatment is best suited for these tumours, and the minimum excision
      distance for basal-cell carcinomas of less than 3 cm in size should be 8 mm,
      while for squamous-cell carcinomas of the same size the distance should be 10 mm.
      For both forms of tumour where the greatest extent is more than 3 cm the excision
      distance should be at least 15 mm.

PMID- 1019588
TI  - Surgical treatment of the rheumatoid thumb. Special reference to the
      metacarpophalangeal joint.

PMID- 1019589
TI  - Cellular patterns in the early phase of healing wounds in children.
AB  - Cellular patterns of the healing incisional wound were studied in 55 pediatric
      surgical patients by the CELLSTIC method. This wound drain, specially developed
      for this purpose, consists af a standard-sized, viscose cellulose sponge, inside
      a thin silicone rubber tube. When left between the wound edges, wound exudate
      flows outwards through the drain, allowing its cells to attach to the sponge
      surface. The sponge serves as a framework where the cells may migrate, divide and
      transform. During the first 12 hours the cellular pattern in the sponge resembles
      that of peripheral blood, whereafter the number of polymorphonuclear leukocytes,
      almost exclusively neutrophils, gradually increases. Later on lymphocytes and
      monocytes invade. The first fibroblasts were seen at the end of the third
      postoperative day.

PMID- 1019590
TI  - Studies on healing of Debrisan-treated wounds.
AB  - Debrisan (Pharmacia AB, Sweden) is a highly hydrophilic dextran polymer in the
      form of dry, spheric beads. When dry Debrisan beads are placed on a wound, the
      wound secretions are sucked up into and between the beads. No crust is formed on
      the wound. Bacteria granular substances are removed with the secretions.
      Treatment with Debrisan was found to be very effective in cleansing discharging
      wounds. Since Debrisan treatment removes substances from the wound area, e.g.
      prostaglandins, this might affect the process of repair. The morphology of wounds
      was studied with the aid of histological and histochemical methods. In 15
      patients, donor sites on one thigh, treated with Debrisan, were compared with
      donor sites on the contralateral thigh, subjected to open treatment. In pigs,
      comparison was made between Debrisan-treated with Vaseline-gauze-covered dermal
      burns. In man, the inflammatory reaction was less pronounced in the Debrisan
      treated wound and located more superficially then in the wound left open, where
      perivascular inflammatory cell infiltrates were found even deep in the dermis. In
      pigs the burns exhibited similar differences. Thus the inflammatory reaction in
      the Debrisan-treated wounds was less pronounced than in the control wounds.
      Debrisan beads were never seen below the wound surface. No unfavourable influence
      of Debrisan treatment was observed on the process of repair.

PMID- 1019591
TI  - Linguistic relativity and the diagnosis of schizophrenia.

PMID- 1019592
TI  - Psychophamacological treatment.

PMID- 1019593
TI  - Schizophrenia and sensitivity to the family environment.

PMID- 1019594
TI  - Exposure to trichloroethylene I. Uptake and distribution in man.
AB  - Fifteen healthy male subjects were exposed to about 540 and 1,080 mg/m3 of
      trichloroethylene (TRI) in the air during rest and exercise on a bicycle
      ergometer. Each subject was exposed during four 30-min periods. The arterial
      blood concentration increased linearly with the concentration in the alveolar
      air. The uptake of TRI was about 55% of the supplied amount at rest. At a work
      load of 150 W during the fourth period the percentage uptake decreased to about
      25%. For one fairly thin subject the uptake was near zero at the end of exposure.
      This development was probably due to the relatively low solubility of TRI in
      blood and tissues. The uptake of TRI may be estimated from pulmonary ventilation
      and the concentration in alveolar and inspiratory air.

PMID- 1019595
TI  - Exposure to trichloroethylene II. Metabolites in blood and urine.
AB  - Fifteen men were exposed to trichloroethylene (TRI) in three different ways with
      regard to the concentration of TRI in the air as well as exercise on a bicycle
      ergometer. The total amount of TRI supplied and taken up by each person was
      measured. The concentrations of trichloroethanol (TCE) and trichloroacetic acid
      (TCA) were determined in blood and urine. In spite of large differences in
      uptake, there were only small differences in the concentration of TCA in blood
      during the day of exposure. There was a large scatter for the values of TCA in
      urine within each group. The concentration of TCE in arterial blood increased
      during exposure. Thereafter the concentrations were almost constant for 2 h and
      differed among the groups. These results can be interpreted as being due to
      balanced rates of the formation and elimination of TCE. The levels mentioned were
      related to the uptake of TRI. The same was found for the rate of excretion of TCE
      in urine when calculations were made from the morning sample obtained the day
      after exposure.

PMID- 1019596
TI  - Exposure to trichloroethylene III. Psychological functions.
AB  - The effect of exposure to the solvent trichloroethylene (TRI) on the performance
      of tests of numerical ability, reaction time (simple and choice), and short-term
      memory was studied in 15 healthy male subjects. The subjects were tested
      individually on three different occasions during exposure to 540 and 1,080 mg/m3
      of TRI in inspiratory air and under control conditions, respectively. At
      predetermined times during the three 70-min exposure periods, samples were taken
      of the subjects' alveolar air. Neither the reaction time tests nor the short-term
      memory test showed any signs of performance decrement during exposure to TRI as
      compared to those administered under control conditions. However, a statistically
      significant decrement in performance was obtained on the test of numerical
      ability during exposure to TRI. The results as a whole indicate that there should
      not be any risk of an acute effect on central nervous functions at concentrations
      which do not considerably exceed the Swedish threshold limit value for the
      solvent (160 mg/m3).

PMID- 1019597
TI  - Relationships between lead absorption and peripheral nerve conduction velocities
      in lead workers.
AB  - The motor sensory, and mixed nerve conduction velocities of median and posterior
      tibial nerves were measured in 39 lead workers whose blood lead (PbB)
      concentrations ranged from 2 to 73  mug/100 g with anaverage of 29 mug/100 g. The
      PbB concentrations significantly correlated with the maximal motor nerve
      conduction velocities (MCV) and mixed nerve conduction velocities (MNCV) of the
      median nerve in the forearm and with the MCV of the posterior tibial nerve.
      Erythrocyte delta-aminolevulinic acid dehydratase (ALAD) activity correlated
      similarly with the MCV and MNCV of the median nerve in the forearm, and the 24
      hour urinary lead excretion following the intravenous administration of CaEDTA
      (20 mg/kg) (lead mobilization test) correlated with the MNCV. But no parameter
      correlated with the sensory nerve conduction velocities. By multiple regression
      analysis, a combination of the three parameters of lead absorption was found to
      correlate significantly with the MCV and MNCV of the median nerve in the forearm.
      The MCVs of the median and posterior tibial nerves in lead workers were
      significantly delayed in the PbB range of 29-73 mug/100 g (mean 45), in the lead
      mobilization test range from 173 to 3,540 mug/day (mean 973), and the ALAD
      activity range from 4.4 to 19.4 u. (mean 14.0), respectively.

PMID- 1019598
TI  - Magnetic measurements of pulmonary contamination.
AB  - The magnitic determination of pulmonary contamination is based on the remanent
      magnetization of ferromagnetic contaminating particles. The remanent field of the
      externally magnetized particles is proportional to their amount and shows their
      distribution. Although only magnetizable particles are detected with this method,
      the amount of the inhaled ferromagnetic substance can be used when the total dust
      exposure of the worker is estimated. In this work five shipyard welders were
      studied. First the particles disposed to the lungs were externally magnetized and
      then their distribution was mapped with a sensitive magnetometer. The magnitudes
      of the remanent fields measured from the welders differed from the fields
      measured from controls by several orders of magnitude. The radiographic findings
      showed a good correlation with the magnetic measurements, and further experiments
      will prove whether this method can partly replace presently used radiological
      investigations.

PMID- 1019599
TI  - Cardiopulmoanry bypass hemorrhage: a surgeon's point of view.

PMID- 1019600
TI  - [Efficacy and usefulness of injectable dibencozide for uremia due solely to
      prerenal causes or in addition to chronic renal insufficiency].

PMID- 1019601
TI  - [Basic treatment of angina pectoris in current practice].

PMID- 1019602
TI  - [New therapeutic approach to cutaneo-mucous mycoses].

PMID- 1019603
TI  - [Local chemical contraception: results based on 4 years of experimentation].

PMID- 1019604
TI  - [Objective method of assessment of psychotonic drugs for fatigue].

PMID- 1019605
TI  - [A new type of medical thermometer: the disposable buccal thermometer].

PMID- 1019606
TI  - [Metastatic liver: new therapeutic trends].

PMID- 1019607
TI  - [Present status of Primperan in the surgical milieu].

PMID- 1019608
TI  - Of death and euthanasia.

PMID- 1019609
TI  - The Whampoa-Kallang malaria outbreak, 1974-5.

PMID- 1019611
TI  - Photo coagulation in the management of retinal disorders--a preliminary report.

PMID- 1019610
TI  - Malignant melanomas of the upper respiratory tract.

PMID- 1019612
TI  - Quality of life and the right to live.

PMID- 1019613
TI  - [Clinico-pathological aspects of malignant lymphoma of the gastrointestinal tract
      in Malaysia].

PMID- 1019614
TI  - Experience of a comprehensive infertility clinic in the Department of Obstetrics
      and Gynaecology, University of Singapore.

PMID- 1019615
TI  - Rheumatoid arthritis in Singapore, a clinical study.

PMID- 1019616
TI  - The pattern of traumatic spinal cord lesions in Singapore--an analysis of 70
      patients admitted to the spinal unit, Department of Rehabilitation Medicine, Tan
      Tock Seng hospital.

PMID- 1019617
TI  - Pyloric stenosis in the ethnic groups of Singapore.

PMID- 1019618
TI  - Dermal icteric zones and serum bilirubin levels in neonatal jaundice.

PMID- 1019619
TI  - Cardiac beri-beri presenting with shock.

PMID- 1019620
TI  - Pulmonary sarcoidosis in a Chinese woman.

PMID- 1019621
TI  - Variables in the outcome of genetic counseling.

PMID- 1019622
TI  - The genetics of affective disorder and genetic counseling.

PMID- 1019623
TI  - Schizophrenia: a bag of dilemmas.

PMID- 1019624
TI  - Inbreeding as measured by isonymy and by pedigrees in Kippel, Switzerland.

PMID- 1019625
TI  - Demographic studies in a Brazilian  population of Arabian origin.

PMID- 1019626
TI  - Delinquency, sex and family variables.

PMID- 1019627
TI  - An unusual live-birth sex ratio in Ecuador.

PMID- 1019628
TI  - Clinical laboratories: influence of increased productivity and new laboratory
      instruments on health care.

PMID- 1019630
TI  - Cryotherapy.

PMID- 1019629
TI  - Fluid resuscitation of burn patients: does clinical "success" necessitate
      "excess".

PMID- 1019631
TI  - Cryosurgery for benign and malignant skin lesions: treatment with a new
      instrument.
AB  - The Foster "Froster" unit is a new and simplified liquid nitrogen system for use
      in dermatologic cryosurgery. The details of its operation are described and its
      use in various benign, premalignant, and malignant lesions is discussed. In
      malignant lesions, not only type, but frequently location, is important when
      deciding whether to use cryosurgery as the first, alternate, or adjunctive choice
      of therapy. Benign and premalignant lesions which respond best are sebaceous
      hyperplasia, dermatofibromas, actinic keratoses, leukoplakias, lentigines, and
      certain seborrheic keratoses and verrucae. Initial promising results have been
      reported in cases of swimming pool granuloma and chromoblastomycosis. Application
      of the described technics in one's clinical practice must depend primarily on the
      level of knowledge of skin lesions and on the degree of skill attained in
      cryosurgical methods.

PMID- 1019632
TI  - Changes in the clinical picture of schizophrenia.
AB  - Records of all patients admitted to inpatient facilities of a state department of
      mental health from 1948 to 1952 and from 1965 to 1969 and diagnosed schizophrenic
      were reviewed to determine diagnostic trends, if any. The percentage of diagnoses
      of the catatonic subtype showed a general decline, the hebephrenic subtype showed
      a marked decline, the paranoid subtype a general increase, and the nonclassical
      subtypes a marked increase. Analysis of the symptoms for the subtypes and
      comparison between subtypes did not reveal any particular symptoms to be totally
      characteristic of a specific subtype. Many symptoms occurred with approximately
      equal frequency in all subtypes. Comparison of patients' symptoms for the two
      periods did not reveal wide qualitative variation between periods. However, there
      were large quantitative variations. We conclude that the apparent change in
      schizophrenia is but a moderation of primary symptoms.

PMID- 1019633
TI  - Septicemia, gastroenteritis, cholecystitis due to Arizona sp.

PMID- 1019634
TI  - Negative blood cultures in infective endocarditis: a review.

PMID- 1019635
TI  - Diagnostic value of a chemistry test profile.
AB  - Serum chemistry test results were correlated with discharge diagnoses of 4,295
      persons admitted to an acute care general hospital in a seven-month period. The
      diagnostic value of the test results, separately and in combinations of up to 12
      tests, were calculated at each of ten levels as measured from the mean of normal
      in standard deviations. All patients had a serum profile consisting of total
      calcium, inorganic phosphorus, glucose, urea nitrogen, uric acid, cholesterol,
      total protein, albumin, total bilirubin, alkaline phosphatase, lactic
      dehydrogenase, and glutamic oxaloacetic transaminase levels. Analysis by manual
      and computer technics is illustrated. Computerized analysis of a chemistry
      profile is reported as a list of diagnostic possibilities in ranking order, with
      the calculated probability for each. In this preliminary report individual
      diseases are replaced by categories of disease taken from The International
      Classification of Diseases, Adapted (ICDA).

PMID- 1019636
TI  - Polytomography in an otologic practice.
AB  - The polytome should be used as an adjunct to conventional roentgenograms of the
      temporal bone and not as a substitute. The purpose of this paper is to
      demonstrate how the polytome has been used to great advantage in a private
      otologic practice.

PMID- 1019637
TI  - Cardiac arrest after edrophonium therapy of supraventricular tachycardia.

PMID- 1019638
TI  - Basilic vein to brachial artery fistula: a new access for chronic hemodialysis.
AB  - A new vascular access for chronic hemodialysis is developed by creating a fistula
      in the upper arm between the end of the relocated basilic vein and anterior
      aspect of the brachial artery. The procedure has been used 24 times in 23
      patients over the past 15 months (average eight months) with minimal
      complications and low failure rates. This fistula provides a straight, long,
      easily accessible conduit with high flows; it has only one vascular anastomosis
      and maintains the anatomic continuity of its venous end with the axillary vein.
      It also obviates the need for autologous, prosthetic, or heterografts. The
      procedure is indicated when suitable vessels in the forearm have been exhausted
      or are unavailable. However, additional clinical trials and continued long-term
      follow-up are necessary for more definite conclusions.

PMID- 1019639
TI  - Etiologic factors in lead nephropathy.
AB  - The rare occurrence of lead nephropathy in widely differing circumstances has
      suggested that additional causative factors might be required for its production.
      Seventeen cases of interstitial nephritis associated with severe chronic lead
      poisoning were reviewed in an attempt to identify these. Data suggested that
      alcoholism and preexistent hypertension, and also previous or minor urinary tract
      disease, may potentiate the injurious effects of lead. We recommend that the
      diagnosis of lead nephropathy should be a positive one, not one of exclusion, and
      that stored lead should be removed, particularly in persons with hypertension or
      previous urinary tract diseases.

PMID- 1019640
TI  - Surgical treatment of reflux in completely duplicated ureters.
AB  - Vesicoureteral reflux occurs in approximately 50% of duplex systems that undergo
      evaluation and most commonly involves the lower renal segment ureter. The
      therapeutic approach can be tailored for each case after careful evaluation of
      the anatomic and functional status of each renal unit. If reparative srugery is
      indicated and only one ureter is involved, then ureteropyelostomy or
      ureteroureterostomy have yielded excellent results. If more than one ureter is
      involved with either relfux or obstruction, then reimplantation of the paired
      ureters is indicated if the renal units are slavageable.

PMID- 1019641
TI  - Tay-Sachs disease: a pilot screening program for the detection of the
      heterozygote in the Charleston Jewish community.
AB  - A pilot screening program for the detection of the carrier (heterozygote) of the
      Tay-Sachs disease (TSD) gene has recently been completed at the Medical
      University of South Carolina. A fluorometric assay for serum hexosaminidase A and
      B was performed on the serum of 181 individuals from the Charleston Jewish
      community. One hundred seventy-six of these individuals were classified as normal
      based on the percent hexosaminidase A (Hex A) in their serum; five persons were
      classified as carriers of the Tay-Sachs gene, including a young married couple
      who were later referred for genetic counseling.

PMID- 1019642
TI  - Ovarian pregnancies with Dalkon Shield IUCDs in situ: laparoscopic visualization.
AB  - Two ovarian pregnancies coexistent with intra-uterine contraceptive devices are
      described. In one case, the ovary appeared to contain a cyst at laparoscopy and
      rupture of the cyst and extrusion of the fetus were witnessed. In the second
      case, a hemorrhagic ovarian cyst bled at laparoscopy and laparotomy resulted in
      the diagnosis of ovarian pregnancy. These two cases reveal that laparoscopic
      examination could be misleading and result in inappropriate management if the
      diagnosis of ovarian pregnancy is not entertained. The cases described add to the
      growing number of reports of extrauterine pregnancies occurring in patients using
      intra-uterine contraceptive devices.

PMID- 1019643
TI  - Management of patients with modified Hunt pouch esophagojejunostomy after total
      gastrectomy for carcinoma of stomach.
AB  - The Hunt pouch and its various modifications have been used as an
      esophagojujunostomy technic after total gastrectomy or esophagogastrectomy for
      benign and malignant conditions. This pouch procedure may be particularly useful
      for palliative gastric resections in which the patient's ability to ingest
      adequate foodstuffs might be enhanced by a larger reservoir, thereby improving
      nutritional status and possibly facilitating chemotherapy or radiation therapy or
      both. Intravenous hyperlimentation has been used to advantage preoperatively and
      postoperatively to help nutritionally depleted patients better tolerate such an
      operation and has been useful during treatment of complications related to the
      procedure. Three recent cases are discussed to illustrate the above propositions.

PMID- 1019645
TI  - A new approach to pilonidal sinus excision.

PMID- 1019644
TI  - Superior mesenteric artery (Wilkie's) syndrome: report of three cases and review
      of the literature.
AB  - Of the three cases of superior mesenteric artery (Wilkie's) syndrome presented,
      one was associated with anorexia nervosa; this association has not been reported
      before. Two patients were treated surgically with a duodenojejunostomy, and one
      was treated medically. Vascular compression of the duodenum is a controversial
      subject. The syndrome probably is more common than generally recognized and is
      underdiagnosed due to its exclusion from the differential diagnosis of small
      bowel obstruction. Its recognition is important because early diagnosis of a
      partial obstruction may allow for medical rather than surgical intervention, as
      exemplified by our third case.

PMID- 1019646
TI  - Hypnosis in surgery--why and when.
AB  - Hypnosis offers an excellent alternative to conventional anesthesia in certain
      selected or complicated cases. Ten different patients were selected from a group
      of 38 and were studied thoroughly. Good surgery and a smooth recovery were
      possible through hypnosis, alone or with conventional anesthesia.

PMID- 1019647
TI  - Bridging: an effective and practical method of preventive skin care for the
      immobilized person.
AB  - Various methods have been used in an attempt to decrease prolonged pressure on
      skin, especially over bony prominences, and thus prevent pressure sores in
      immobilized patients: turning frames, circle beds, flotation beds, and special
      mattresses. Bridging is one means of relieving pressure on bony prominences which
      is both simple and inexpensive. Through the proper positioning of pillows, a
      patient is supported above the surface of the bed with free space between the
      bony prominences and the bed surface. Several different positions for pressure
      relief are possible. Advantages of the technic include its low cost, patient
      acceptance, lack of mechanical components which can fail, and ease of training
      personnel or family members to carry it out.

PMID- 1019648
TI  - Survey of sudden death in the offices of Atlanta physicians and dentists.

PMID- 1019649
TI  - Postoperative infection of lumbar intervertebral disk space.
AB  - Sixteen cases of postoperative intervertebral disk space infection are reviewed.
      Most occurred after diskectomy, but one followed an unsuccessful attempt at a
      spinal anesthetic and two followed diskography. Treatment varied from aggressive
      surgery, either by a posterior, lateral, or anterior approach, to drain the
      infected disk space or spaces, to more conservative immobilization. Antibiotics
      were used in all cases. Needle biopsy is valuable in establishing diagnosis and
      identifying the organism and its antibiotic sensitivities. In some cases fusion
      occurred spontaneously from the infection; in others, fusion was a result of
      surgical fusion preceding or following the infection.

PMID- 1019650
TI  - Pulmonary vein obstruction by bronchogenic carcinoma.
AB  - Two patients with obstruction of the pulmonary veins by bronchogenic carcinoma,
      an unusual cause, are presented. These and other cases reported have had features
      suggestive of mitral stenosis. The differential diagnosis is discussed.

PMID- 1019651
TI  - The detection of glass foreign bodies.
AB  - Roentgenography is a reliable method for detecting glass foreign bodies resulting
      from trauma. The density of glass in comparison to surrounding tissue almost
      always provides sufficient contrast for roentgenographic differentiation. This
      method is slightly compromised by the relative size of the foreign body and the
      body part being examined, but setting the roentgen ray beam for bone technic and
      having the patient in different positions facilitate detection of such a foreign
      body.

PMID- 1019652
TI  - Arthroscopy of the knee joint.

PMID- 1019653
TI  - Fracture-dislocation of the dorsal spine.
AB  - A patient with fracture-dislocation of D9 on D8 had considerable posterolateral
      displacement. The neurologic injolvement of his left leg proved to be
      progressive. Treatment consisted of posterior decompression, exploration, open
      reduction and stabilization by means of Harrington rods, and fusion. All
      neurologic findings resolved completely. Final evaluation 18 months later showed
      a good and serviceable spine with no residual neurologic deficits. In my opinion,
      the treatment used in this case under given circumstances represented a
      reasonable modality of therapy.

PMID- 1019654
TI  - Migrating placenta previa.
AB  - A case of third trimester bleeding from placenta previa is presented in which
      serial ultrasonograms were obtained from the 30th to the 36th gestational week
      and confirmed by isotopic scanning. Evidence is presented showing a migration of
      a placenta previa marginalis away from the cervical os followed by vaginal
      delivery at term. The concept and mechanism of placental migration are reviewed.

PMID- 1019655
TI  - Inflammatory subluxation of the atlantoaxial joint.
AB  - A case of atlantoaxial subluxation accompanying pharyngitis is reported in a 4
      year-old child. Diagnosis was made by examination and roentgenograms of the
      lateral cervical spine. Treatment consisted of halter traction and bracing. The
      patient responded well to treatment and is normal in all respects one year later.
      Atlantoaxial subluxation should be considered when treating pharyngitis,
      especially if the patient presents with torticollis.

PMID- 1019656
TI  - Reye's syndrome in a neonate.
AB  - This case substantiates the fact that Reye's syndrome can occur in newborns. The
      clinical features appear to be slightly different in the neonate, in that
      respiratory distress was the presenting sign in this case and in the one other
      reported case in a newborn, with no mild preceding illness or vomiting. Thus,
      Reye's syndrome must be considered when a newborn presents with respiratory
      distress and evidence of central nervous system and hepatic involvement.

PMID- 1019657
TI  - Dumbbell granulomatous abscess of the chest wall following needle biopsy of the
      pleura.
AB  - A 38-year-old woman who had a Cope needle biopsy of the pleura was treated for
      plural tuberculosis on the basis of a positive PPD-S skin test and presence of
      caseating granulomas in the pleural biopsy. Ten months later she developed a
      tender, subcutaneous nodule in the area of the previous needle biopsy. Surgical
      exploration revealed a dumbbell abscess through the chest wall communicating with
      an area of consolidation in the right middle lobe. En bloc surgical resection of
      the abscess and peripheral portion of the right middle lobe was curative,
      although all pathologic and cultural studies of the resected tissue were non
      diagnostic.

PMID- 1019658
TI  - Multiple myeloma on polycythemia vera following radioactive phosphorus therapy.
AB  - A 74-year-old white man with established polycythemia vera was treated with
      radioactive phosphorus after phlebotomies alone failed to control his disease.
      About 2 3/4 years later he died of multiple myeloma. The mutagenic effect of
      radioactive phosphorus may have caused or possibly accelerated preexisting
      myeloma. Basic nonmalignant disease deserves careful consideration before
      radiation or radiomimetic agents are used. One might consider a probably less
      mutagenic drug such as hydroxyurea in patients with polycythemia vera when
      phlebotomy alone does not give good control of red cell mass and thrombocytosis.

PMID- 1019659
TI  - Mesenteric thrombosis after penetrating cardiac trauma.
AB  - Survival of the severely injured trauma victim through aggressive therapy results
      in new complications. We report the first instance of mesenteric thrombosis in
      association with penetrating cardiac trauma. Selective visceral angiography
      should be obtained early in a patient with persistent abdominal pain following a
      period of prolonged shock; such cases should have a more favorable prognosis if
      diagnosed early in view of the limited period of cardiac dysfunction and the
      younger age group.

PMID- 1019660
TI  - Dissecting popliteal cyst: an unusual complication of Reiter's syndrome.
AB  - A case of Reiter's syndrome associated with a dissecting popliteal cyst mimicking
      deep vein thrombophlebitis is reported. The cyst was diagnosed by arthrography
      and responded to intra-articular injection of corticosteroids. The diagnosis of a
      dissecting popliteal cyst should be considered in a patient with arthritis of the
      knee joint from any cause and who develops signs and symptoms of
      thrombophlebitis.

PMID- 1019661
TI  - Chlorpropamide-induced hyponatremia.

PMID- 1019663
TI  - Manifestations of cystic fibrosis in adults.

PMID- 1019662
TI  - State psychiatric hospitals: a response.

PMID- 1019664
TI  - Hepatitis B and possibilities for control.

PMID- 1019665
TI  - Adverse psychologic reactions to ileal bypass surgery.
AB  - Of 33 patients who underwent ileal bypass surgery for morbid obesity and were
      followed up with psychiatric interviews and consultation postsurgery, five appear
      to have had adverse psychologic sequelae related to the procedure. The emotional
      problems of these five patients were in part related to or precipitated by their
      drastic weight loss after ileal bypass. In most cases, the patients generally had
      depressive symptoms and, in dynamic terms, were dependent individuals with
      lifelong problems in object relations. The coping styles demonstrated, while not
      rigorously classified as psychiatric illness, appeared to predispose them for
      certain difficulties even when weight had been lost. Ileal bypass surgery
      apparently is not psychologically innocuous as previously thought, and
      psychiatric follow-up of patients is indicated.

PMID- 1019666
TI  - Pneumatosis intestinalis in association with connective tissue disease.
AB  - Pneumatosis intestinalis in association with connective tissue diseases is an
      unusual combination whose pathogenesis is not yet understood. Furthermore,
      steroid medication, often used to treat these diseases, may itself cause
      pneumatosis. Three cases of scleroderma, systemic lupus erythematosus, and
      amyloidosis in association with pneumatosis and without prior steroid therapy are
      presented. The small vessel occlusive pathologic processes in these diseases may
      cause focal areas of mucosal ischemia resulting in small, perhaps transient
      ulcerations that allow gas to enter the gut wall from the lumen.

PMID- 1019667
TI  - Exophthalmos and epidural hematoma.
AB  - The development of a right exophthalmos in a patient with a left hemispheric
      epidural hematoma is reported. The parallel development of these two conditions
      in this unusual case suggests some direct relationship, although it must be
      recognized that a coincidental relationship is possible. The exact cause of the
      exophthalmos remains obscure.

PMID- 1019668
TI  - Long-term follow-up of hip fractures.
AB  - Hip fractures on 117 patients treated surgically and followed up for an average
      of 10.2 months are reviewed. Among the parameters analyzed were complications,
      mortality, clinical follow-up by the operating surgeon, and the ability to
      ambulate after surgery. Postoperative surgical complications occurred in 36% and
      medical complications in 18% of the patients. Mortality was 25% within the first
      year after surgery. Sixty-one percent of the patients returned at least once to
      the surgeon's office for follow-up; only 38% were followed for more than six
      months. In the surviving patients who were good ambulators before hip fracture,
      60% to 70% became good ambulators postoperatively. Only 20% to 30% of the
      surviving patients who were poor ambulators preoperatively ever walked again.

PMID- 1019669
TI  - Induced hypothermia: electrocardiographic abnormalities.
AB  - Hypothermia was induced intermittently in a patient to combat hyperpyrexia. The
      electrocardiogram taken during the hypothermic phase displayed typical
      abnormalities and consisted of: pronounced sinus bradycardia, marked prolongation
      of the Q-T interval, muscle tremor artifact, and the characteristic "Osborn
      wave." Spontaneous rewarming resulted in disappearance of the
      electrocardiographic alterations, underscoring the functional and reversible
      nature of the abnormalities.

PMID- 1019670
TI  - Autoimmune atrophic gastritis with hypergastrinemia.
AB  - Elevation in fasting serum gastrin levels was found in three patients being
      evaluated for persistent upper abdominal pain without radiographic evidence of
      peptic ulcer disease. Fiberoptic endoscopy of the upper gastrointestinal tract in
      each patient revealed characteristic changes of chronic atrophic gastritis.
      Gastric biopsies showed diffuse chronic inflammation in the lamina propria, a
      decrease in the number of parietal cells, and "intestinalization" of gastric
      mucosa. Total achlorhydria was demonstrated after a maximal histalog stimulus;
      however, serum levels of vitamin B12 and Schilling test values were normal in all
      three patients. Parietal cell antibodies were found in the serum in all patients
      in a dilution of 1:20 to 1:80. These cases represent autoimmune (type A) chronic
      atrophic gastritis and should be distinguished from chronic simple (type B)
      gastritis, in which serum gastrin levels are normal and no parietal cell
      antibodies are found in the serum. Patients with autoimmune gastritis should be
      observed at frequent intervals for the occurrence of pernicious anemia or gastric
      carcinoma.

PMID- 1019671
TI  - Mediastinal and subcutaneous emphysema in labor.
AB  - The recent world literature on mediastinal emphysema has been reviewed and two
      cases added. This condition is relatively benign, and the supportive treatment is
      discussed. Subsequent pregnancies have been uncomplicated.

PMID- 1019672
TI  - Pelvic lipomatosis.
AB  - A case report of pelvic lipomatosis in a woman is presented. This condition is a
      benign, apparently self-limited disease in which mature adipose tissue is
      deposited in the pelvis. The clinical presentation is discussed.

PMID- 1019673
TI  - Complications of total hip replacement.
AB  - The most common complications of total hip replacement are infection, loosening,
      dislocation, phlebothrombosis and embolism, neurovascular deficity, periarticular
      calcification, nonunion of the greater trochanter, malposition of components,
      fractures, and discrepancy in leg length. The cause, prevention, and treatment of
      these complications are reviewed.

PMID- 1019674
TI  - Sequestration of the lung in children.
AB  - Three instances of intralobar pulmonary sequestration are reported to call
      attention to the occurrence of this lesion in children. In all three patients,
      the sequestration was diagnosed by arteriography and treated by lobectomy.
      Extralobar and intralobar sequestrations are described and the differential
      diagnosis is discussed.

PMID- 1019675
TI  - Hair transplant surgery: planning the procedure.
AB  - Factors important in planning hair transplant surgery are presented. The
      procedure must be designed for each patient individually. Success with hair
      transplantation depends upon developing surgical skill and having an appreciation
      of esthetically pleasing designs.

PMID- 1019676
TI  - The diagnosis of subcapsular hematoma of the liver by scintigraphy.
AB  - The diagnosis of subcapsular hematoma of the liver following blunt abdominal
      trauma has assumed clinical importance with recent reports of improved mortality
      with conservative management. There is increasing use of hepatic scintigraphy in
      evaluation of upper abdominal trauma. Two recently observed cases are used to
      illustrate the typical findings in this entity.

PMID- 1019677
TI  - Psychotherapy as adjunct in treatment of vomiting during pregnancy.
AB  - Adjunctive psychotherapeutic measures were used to treat ten consecutive pregnant
      women referred to a psychiatric consultation service because of severe
      intractable vomiting. In addition to customary medical measures, they received
      three types of psychotherapy: (1) supportive psychotherapy (establishment of
      positive relationship, frequent reassuring conversations, and encouragement of
      expression of thoughts and feelings); (2) hypnotherapy (trance induction and
      suggestions of comfort in the gastrointestinal tract, desirability of feeling of
      substance in stomach, and ability to retain and digest food eaten); and (3)
      behavior modification (positive reinforcement for retaining food and gaining
      weight, through granting desirable considerations such as visitors, radio,
      television, and being up in or outside the room). Results were encouraging. Nine
      patients recovered and completed normal pregnancies, while one improved but later
      aborted due to other complications. When compared with a control group of
      routinely treated patients, recovery was more rapid.

PMID- 1019678
TI  - Teaching sex education and counseling for the primary physician.
AB  - Today's family physicians are being confronted by increasing numbers of patients
      who desire and need sex education and counseling. It is suggested that the family
      and primary physician can approach the multiple sex-related needs of the family
      by understanding the family life cycle and by using permission-giving, limited
      information, and specific suggestions with patients as needed and as appropriate.
      The experience of the University of Miami's Department of Family Medicine in
      teaching human sexuality to medical students, residents, and faculty of the
      medical center is cited to help other residency programs include sex counseling
      and sex education in the armamentarium of residents.

PMID- 1019679
TI  - Case clustering in cancer.
AB  - There is little evidence that time-space clustering is important in the
      epidemiology of leukemia, lymphoma, Burkitt's tumor, and myeloma. Clustering by
      interpersonal contact, particularly in Hodgkin's disease, does appear to occur,
      but more study is needed to warrant the conclusion that such contact is necessary
      for subsequent illness to develop. Future epidemiologic studies should include
      the use of laboratory analysis to evaluate the role of viruses, genetics, and
      environmental factors in cluster studies.

PMID- 1019680
TI  - Preparation of tables for medical articles: guidelines for physician-authors.
AB  - This review of the basic purposes and principles of tables is oriented toward
      their preparation by physician-authors for use in medical manuscripts. The
      guidelines suggested are consistent with the general format and style current in
      scientific and medical writing, with emphasis upon the latter. Style and usage do
      evolve, though, and even at any given time there may be in existence several
      acceptable variations of "standard" practices. Therefore, the value of style of
      the journal to which a manuscript will be submitted is again emphasized.

PMID- 1019681
TI  - Occult sclerosing carcinoma of the thyroid.
AB  - A case of occult sclerosing thyroid carcinoma is reported. The primary
      requirement for diagnosis is that the cancer is less than 1.5 cm in diameter. In
      addition, a fibrosing component with varying degrees of sclerosis is present.
      Lymph node metastases are frequent and may appear as benign thyroid follicles.
      Occasional direct invasion or vascular invasion may occur. Distant metastases
      were not reported in the series reviewed. Adequate therapy would seem to be total
      thyroidectomy of the involved lobe and radical subtotal thyroidectomy of the
      opposite lobe with excision of all enlarged or involved lymph nodes.

PMID- 1019682
TI  - Granular cell myoblastoma (schwannoma) of the carina in a patient with
      sarcoidosis.
AB  - The sixth case report of granular cell myoblastoma (schwannoma) of the carina,
      occurring in a 22-year-old black woman, is presented. Incidental coexistent
      carcoidosis was present. The various theories of the histogenesis of the lesion
      are reviewed briefly.

PMID- 1019683
TI  - Thrombophlebitis and pulmonary embolism with surgical intervention in the third
      trimester.
AB  - A case of acute deep vein thrombophlebitis and pulmonary embolism in late
      gestation has been presented with a discussion of diagnostic modalities,
      therapeutic regimens, and theoretical considerations. It is our belief that
      aggressive medical management is best accomplished by giving heparin
      intravenously as the primary anticoagulant. When medical management is best
      accomplished by giving heparin intravenously as the primary anticoagulant. When
      medical management is not effective or if embolism occurs, surgical intervention,
      consisting of vena caval clipping and ovarian vein ligation with scrupulous
      attention to detail, is indicated. Further, support to prophylaxis of abruptio
      placenta secondary to the mechanism espoused by Mengert et al is added by the
      course of this patient.

PMID- 1019684
TI  - Transient electrocardiographic changes in anaphylaxis.

PMID- 1019685
TI  - [Status of obstetrical service in the USSR].

PMID- 1019686
TI  - [Repeated hospitalization].

PMID- 1019687
TI  - [Methodological approaches to conducting an experiment in the dispensary care of
      an entire population].

PMID- 1019688
TI  - [Methodological principles of conducting general dispensary care of the
      population].

PMID- 1019689
TI  - [Modern trends in the development of medical technology].

PMID- 1019690
TI  - [Experience with social psychology research linked to the introduction of
      automatic management systems into plblic health].

PMID- 1019691
TI  - [Business meetings in public health].

PMID- 1019692
TI  - [Factors affecting health of young children].

PMID- 1019693
TI  - [Social hygienic aspects of the development of alcoholic habits].

PMID- 1019694
TI  - [Optimization of the teaching of health education in a department of social
      hygiene and public health organization].

PMID- 1019695
TI  - [Ways to improve state sanitary inspection].

PMID- 1019696
TI  - [Organization of call acceptance by the Moscow first aid station in diseases of
      the cardiovascular system].

PMID- 1019697
TI  - [Sociologic study of the families of rural inhabitants].

PMID- 1019698
TI  - [Analysis of statistical data concerning artificial abortions in a number of
      foreign countries].

PMID- 1019699
TI  - [Age-specific incidence of lung cancer and preventive examinations].

PMID- 1019701
TI  - [Improving the administrative-economic service to medical institutions].

PMID- 1019700
TI  - [Introduction of official instructions for medical personnel].

PMID- 1019702
TI  - [Public health in Great Britain and Anglo-Soviet cooperation in the area of
      medicine].

PMID- 1019703
TI  - [Health of the populace and public health administration in Ghana].

PMID- 1019704
TI  - [Instruction in preventive and social medicine in the countries of Latin
      America].

PMID- 1019705
TI  - [Problems of the "medical personnel drain" abroad].

PMID- 1019706
TI  - [Systematic approach to public health administration].

PMID- 1019707
TI  - [Basic trends in clinical endocrinology].

PMID- 1019708
TI  - [Characteristics of clinical symptoms of pituitary adenoma].

PMID- 1019709
TI  - [Sympathetic-adrenal system in physiological and complicated pregnancy].

PMID- 1019710
TI  - [Additional methods of examination in the diagnosis of recurrence of cervical
      cancer].

PMID- 1019711
TI  - [Dynamics of sulfhydryl compound and serotonin content of blood in uterine
      inertia during serotonin therapy].

PMID- 1019712
TI  - [Ways of preventing late pregnancy toxemias].

PMID- 1019713
TI  - [Thermographic characteristics of the breasts in girls with normal menstrual
      cycle and in dysfunctional hemorrhages].

PMID- 1019714
TI  - [Mechanism of therapeutic effect of antidiabetic sulfanilamide drugs].

PMID- 1019715
TI  - [Effectiveness of the glucose tolerance test (GTT) among rural population].

PMID- 1019716
TI  - [Pathomorphological changes in the heart and adrenal glands after alcoholic
      intoxication].

PMID- 1019717
TI  - [Allergic lesion of the nervous system in Stevens-Johnson syndrome].

PMID- 1019718
TI  - [Treatment of urocoproporphyria (porphyria cutanea tarda) with inosine].

PMID- 1019719
TI  - [Comparative study of different methods of treatment of endocrine forms of
      sterility].

PMID- 1019720
TI  - [Indicators of carbohydrate, nucleid acid and lipid metabolism in diabetes
      mellitus].

PMID- 1019721
TI  - [Insulin resistance and anti-insulin hormones].

PMID- 1019722
TI  - [Role of dysgammaglobulinemia in evaluation of severity of diabetes and
      sensitivity to insulin in children with diabetes mellitus].

PMID- 1019723
TI  - [Autoimmune thyroiditis (pathogenesis, clinical course, diagnosis and
      treatment)].

PMID- 1019724
TI  - [Role of surgeon-angiologist in diagnosis and treatment of diabetic angiopathies
      of the limbs].

PMID- 1019725
TI  - [Characteristics of the course and treatment of juvenile diabetes mellitus].

PMID- 1019726
TI  - [Sugar substitutes in the treatment of diabetes mellitus].

PMID- 1019727
TI  - [Content of growth hormone in neoplastic and non-neoplastic diseases].

PMID- 1019728
TI  - [Hearing disorders in small children after purulent meningitis].

PMID- 1019729
TI  - [Lymphocyte transformation test in plasmacytomas].

PMID- 1019730
TI  - [Determination of man's gravity center in the sitting position].

PMID- 1019731
TI  - [Non-specific cellular and humoral immunity in diabetic patients].

PMID- 1019732
TI  - [Last registered spotted typhus epidemic on the territory of Serbia proper
      retrograde epidemiological and serological analysis].

PMID- 1019733
TI  - [The influence of bulbus massage and elastic bandage on the decrease of
      intraocularpressure during preoperative care].

PMID- 1019734
TI  - [Rare injuries in the otorhinolaryngological system].

PMID- 1019735
TI  - [Incidence of bacteriuria in school-girls: determination of bacteriuria through
      urine culture].

PMID- 1019736
TI  - [Medico-legal and clinical aspects of brain concussion].

PMID- 1019737
TI  - [Primary malignant tumor of both ureters].

PMID- 1019738
TI  - [Enormous osteoblastic-osteogenic meningioma].

PMID- 1019739
TI  - [Metallic foreign bodies in the tympanic cavity].

PMID- 1019740
TI  - [Neuropathy in porphyria--electrodiagnostic study].

PMID- 1019741
TI  - [Normocomplementary and hypocomplementary chronic urticarias : clinical,
      biological and patho-histological confrontations].

PMID- 1019742
TI  - [Cytotoxic effect of decomplemented serum on human lymphocyte cultures in uremic
      patients].

PMID- 1019743
TI  - [Myotonolytic effect of Lioresal-A].

PMID- 1019744
TI  - [Metastases of bronchial carcinoma in the pericardium].

PMID- 1019745
TI  - [Polycystogram in carcinoma of the vaginal part of the uterus].

PMID- 1019746
TI  - [Monitoring of adverse reactions to drugs].

PMID- 1019747
TI  - [Idiopathic membrano-proliferating glomerulonephritis].

PMID- 1019748
TI  - [Familial adenomatous polyposis of the colon--Gardner's variant].

PMID- 1019749
TI  - [Membranoproliferating glomerulonephritis with dense intra-membraneous storing].

PMID- 1019750
TI  - [Primary malignant melanoma of the vulva--report of a case].

PMID- 1019751
TI  - Serum immunoglobulin levels in White and Black patients with virus-A and-B
      hepatitis.
AB  - Serum immunoglobulin G, M and A levels were measured in 106 White patients with
      acute virus-A (hepatitis-B surface antigen-negative) hepatitis and 27 White
      patients with acute virus-B (hepatitis-B surface antigen-positive) hepatitis and
      compared with the values previously obtained in Black patients with these
      diseases. The mean serum IgM level in the White patients with virus-A hepatitis
      was significantly higher than that in virus-B hepatitis (p less than 0,001). This
      difference was much more obvious than that in Black patients, mainly due to a
      much lower mean serum IgM response in Black patients with virus-A hepatitis. The
      reason for the blunted IgM response in Black patients with virus-A hepatitis is
      not known, but it may be related to a difference in the reaction against altered
      host tissues rather than any difference in antibody production against the virus
      per se. The mean serum IgG and IgA levels were not significantly different in the
      White patients with virus-A and virus-B hepatitis and they were lower than the
      corresponding figures in Blacks.

PMID- 1019752
TI  - Laboratory studies on the vector capability of Aedes (neomelaniconion)
      unidentatus McIntosh and Aedes (Aedimorphus/ dentatus (Theobald) with West Nile
      and Sindbis viruses.
AB  - Laboratory tests were made with Aedes (Neomelaniconion) unidentatus McIntosh and
      Aedes (Aedimorphus) dentatus (Theobald) collected from the Highveld region of the
      Transvaal, South Africa, to determine their ability of transmit West Nile and
      Sindbis viruses. Viraemic hamsters or a viraemic chick were exposed to the
      mosquitoes as infective meals. Infection of mosquitoes was determined by testing
      mosquitoes individually for the presence of virus 10-26 days later. Transmission
      of virus, attempted between the 10-20th days by exposing hamsters to groups of
      mosquitoes, was not achieved. With West Nile virus, the high concentrations of
      virus required to infect each species led to the conclusion that neither is an
      important vector of this virus. With Sindbis virus and A. unidentatus the 10 per
      cent infection threshold was less than 2,6 logs of virus, while with A. dentatus
      it was about 3,5 logs. This suggests that both species, but more particularly A.
      unidentatus, could be vectors of this virus.

PMID- 1019753
TI  - The feeding pattern of the fruit bat Rousettus aegyptiacus in captivity.
AB  - An electrical apparatus was designed to record continuously the feeding activity
      of either a colony of 30 fruit bats (Rousettus aegyptiacus) or single bats in
      captivity. The endogenous feeding activity rhythm was synchronized by change in
      the external light-dark cycle. During June to August (winter), the bats consumed
      an average of 96 g sliced banana, equal to 76 g wet weight/100 g body weight per
      24 hours or 15 g dry weight/100 g body weight per 24 hours. The feeding period
      began shortly after sunset and continued for 10,6 h. Feeding consisted of 6-14
      separate small meals. The mean or overall feeding rate was 9,1 g banana/h, and
      the feeding rate during the first 3 h, 13,1 g/h. The bat regulated its food
      intake by varying the rate of food consumption and not by changing the duration
      of  the feeding period. It is suggested that clustering of the bats may influence
      the caloric intake by reducing the energetic cost of thermoregulation.

PMID- 1019754
TI  - GLC determination of paracetamol and d-propoxyphene.
AB  - d-Propoxyphene and d-norpropoxyphene were determined in rat plasms, rat brain
      homogenates and human plasma by means of GLC utilizing extracts obtained by micro
      phase extraction of the drugs. Paracetamol was determined in the same samples by
      GLC separation of the O-butyrate derivative using caffeine as internal standard.
      The problems associated with the GLC determination of d-propoxyphene and d
      norpropoxyphene in biological material are discussed and attention is drawn to
      the particular advantages of the micro-phase extraction procedure for the
      quantitative determination of these drugs.

PMID- 1019755
TI  - [Liberal medicine and institutional medicine in Mexico].

PMID- 1019756
TI  - [Current concepts on the epidemiology of viral hepatitis. Preventive measures and
      management of outbreaks].

PMID- 1019757
TI  - [Deaths from violent causes and their relation to injuries in the body cavities].

PMID- 1019758
TI  - [Influence of climate and vaccination on the incidence of poliomyelitis].

PMID- 1019759
TI  - [Syphilis. Various aspects of its ecology and epidemiological behavior].

PMID- 1019760
TI  - [The path of teaching psychiatry in the Mexico of today].

PMID- 1019761
TI  - [Experimental mental health program in high schools].

PMID- 1019762
TI  - [Mental and neurologic disorders in the Republic of Mexico and in the Federal
      District].

PMID- 1019763
TI  - [Use of factor analysis in the selection of variables of interest in public
      health].

PMID- 1019764
TI  - [Neurological epidemiology in Mexico. Study of an urban population sample].

PMID- 1019765
TI  - [Epidemiological study of neurological diseases in a social security system
      (ISSSTE)].

PMID- 1019766
TI  - [Noise and its effects].

PMID- 1019767
TI  - [Demographic changes in family planning programs].

PMID- 1019768
TI  - [Mortality by causes in Latin America].

PMID- 1019769
TI  - [Preliminary study of bacterial contamination in a seminatural culture of
      Spirulina].

PMID- 1019770
TI  - [A proposition of underdevelopment].

PMID- 1019771
TI  - [The antimicrobial agents and public health].

PMID- 1019772
TI  - [Serological response to typhoid vaccine].

PMID- 1019773
TI  - [Creeping verminous eruption in Yucatan, Mexico. Clinico-epidemiological study].

PMID- 1019774
TI  - [Bovine tuberculosis in the valley of Mexico].

PMID- 1019775
TI  - Current problems regarding the hygiene of the environment and the international
      co-operation.

PMID- 1019776
TI  - Characteristics, objectives and activities of an institution for the improvement
      of public health management.

PMID- 1019777
TI  - The crisis of the bourgeois conceptions in the field of health protection
      economy.

PMID- 1019778
TI  - [The physician and health education].

PMID- 1019779
TI  - The importance of system aspects analysis of disability in industrial medical
      practice.

PMID- 1019780
TI  - Efficiency of selected methods in contact flouride prophylaxis combined with
      dental health education.

PMID- 1019781
TI  - The organization and activities of the health statistics system in Hungary.

PMID- 1019782
TI  - [Suggestions relative to the optimization of medical irradiation of children in
      the village of Cluj-Napoca (Rumania)].

PMID- 1019783
TI  - Causes of death in men living in urban areas within a period of ten years. 1-st
      part.

PMID- 1019784
TI  - [Results of use of the ambulatory method in mental disorders].

PMID- 1019785
TI  - [Protection of health in the People's Republic of Mongolia].

PMID- 1019786
TI  - The medical diagnosis as a specific problem of knowledge.

PMID- 1019787
TI  - Contribution to the appreciation of the mean values of physical development
      indices in children and adolescents according to age groups and sex.

PMID- 1019788
TI  - [Mathematic models in the study of planetary contamination].

PMID- 1019789
TI  - [Ischemic heart disease in North Viet-Nam (general and preliminary remarks)].

PMID- 1019791
TI  - The implementation of the new directions in the organization, activity and
      building of nursing homes in Hungary.

PMID- 1019790
TI  - The morbidity through heart ischaemia in men in urban areas within a period of
      ten years. Part II.

PMID- 1019792
TI  - [Work requirements in the construction industry].

PMID- 1019793
TI  - The quantity and quality of social services.

PMID- 1019794
TI  - Management by objectives in a hospital social service unit.
AB  - A Management By Objectives (MBO) system has been installed in the Social Service
      Department of the University of Minnesota Hospitals. MBO involves administering
      organizations through establishment and follow-up of goals. In order to
      accomodate a human service milieu two additions have been made to the usual MBO
      format: (a) a statement of program philosophy, and (b) a statement of essential
      program functions. Staff reaction to the system has been mixed, while hospital
      administration has been uniformly favorable. In the future the MBO system will be
      integrated with a management information system, and "significant others" will be
      surveyed to get more outside input inot the formulation of objectives. MBO meets
      organizational needs for effective planning, management of resources and control,
      while at the same time maximizing staff input into the overall operation.

PMID- 1019795
TI  - The status of graduate-level social workers teaching in medical schools.
AB  - At present, relatively little national data are available concerning the
      involvement of social workers in medical education. This article presents the
      results of a study conducted recently to obtain a comprehensive, up-to-date
      profile of graduate-level social workers teaching in medical schools and to
      survey the opinions of medical school deans regarding their present and future
      status. Continuing research in this area is essential if we are to acquire a
      greater understanding of the contribution social workers make to contemporary
      medical education. Only then will we be better equipped to assess social work's
      potentials for the future and take those steps necessary to bring them to
      fruition.

PMID- 1019796
TI  - The HMOs: new models for practice.
AB  - New areas of practice are open to innovative social workers in an existing and
      expanding comprehensive health care delivery system--the health maintenance
      organization (HMO). In this article, four health plan models are described that
      document the experience of social workers in established HMOs. These
      illustrations demonstrate the necessity and opportunity for expanded social work
      roles in humanizing and corrdinating patient services in complex
      multidisciplinary health care delivery systems.

PMID- 1019797
TI  - Education for social work in health care organizations.
AB  - The American health care delivery system stands on the brink of major change and
      reorganization. There are many opportunities for the social work profession to
      increase its influence and expand the scale of its activities within health care.
      These opportunities represent a challenge to the vision, creativity, and
      flexibility of social work educators. This article discusseses educators' roles
      within the context of a system conceptualization of the inputs throughputs, and
      outputs of education for social work in health care organizations.

PMID- 1019798
TI  - Interdisciplinary education for community health: the case for nursing and social
      work collaboration.
AB  - A nurse educator and a social work educator developed an interdisciplinary team
      taught course in community health for both social work and nursing students. This
      account of their experience elaborates the implications of interdisciplinary
      education for the student learning experience including theory and practice
      content, socialization, and transition; faculty development; and the larger
      university community. Although this particular instance is limited to
      baccalaureate education, the authors underscore the potential of
      interdisciplinary course work for the enrichment of all levels of nursing and
      social work education.

PMID- 1019799
TI  - Social work education for the field of health: a report of findings from a survey
      of curricula.
AB  - This paper presents the findings of a survey of programs in schools of social
      work made with specific reference to content germane to the field of health. The
      62 schools responding to this inquiry constituted a representative sample of the
      85 members of the Council on Social Work Education in 1972-73 in almost all
      regions of the United States and Canada. The inquiry included questions
      regarding; (a) specialization; (b) courses in health care systems; (c) courses in
      social work practice; (d) field practice; (e) interdisciplinary collaboration;
      (f) educational innovations; and (g) faculty coordinating the health component in
      the curriculum. Findings suggest a remarkably modest thrust in the direction of
      health and specialization at a time when health care is undergoing uncommonly
      rapid change.

PMID- 1019800
TI  - Psychosocial factors in low-incidence genetic disease: the case of osteogenesis
      imperfecta.
AB  - Osteogenesis imperfecta (OI), a dominant genetic disorder, was examined in an
      exploratory case study of psychosocial implications. The cross-sectional survey
      sample consisted of 13 OI-affected adults and 21 families with an OI-affected
      child who were interviewed. Findings revealed numerous psychosocial concerns and
      problems in addition to their complex and lifelong medical problems. Specific
      problem areas differed according to the severity of the disease, type, and mode
      of genetic inheritance. The results indicate the need for local as well as
      national policy changes through legislation and extensions of existing services
      for low-incidence disease groups such as OI-affected persons. Implications for
      social work practice interventions call for greater involvement with genetic
      diseases, more aggressive approaches in case identification and service
      coordination, and performing longer-range monitoring functions than is usually
      the case.

PMID- 1019801
TI  - Crisis intervention in a newborn nursery intensive care unit.
AB  - Premature birth of a defective infant challenges personal and family integrity,
      and immediate intervention is optimal in reaching a positive outcome. The G. case
      exemplifies many aspects of crisis theory; worker intervention was built around
      them. As the G. family struggled with the impact of a severely damaged infant, a
      broad range of worker techniques, based on the parents' strengths and personal
      backgrounds, was required. Intervention was significant in effecting a positive
      resolution. This article details the events endured by the G. family, and the way
      in which they experienced them during their baby's first 3 weeks of life.

PMID- 1019802
TI  - Participatory governance: a model for shared decision making.
AB  - The sharing in departmental decision making is viewed as a responsibility to be
      borne collaterally with the director by practitioners delivering direct services.
      While the process is viewed as consonant with professional growth and therefore
      properly evolutionary, the authors after facilitating premises and structures as
      well as a delineation of risks and rewards.

PMID- 1019803
TI  - Nursing home decision makers and the social service needs of residents.

PMID- 1019804
TI  - Unmet social service needs in skilled nursing facilities: documentation for
      action.
AB  - The skilled nursing facilities in Hennepin County were surveyed to measure 21
      specific social services in five general categories of service. Quantitative
      distribution summaries were made on understanding, performance, and satisfaction
      for each social service, and the five general categories of service were
      compared. Cross-tabulations indicate a significant difference in facilities with
      social work staff. Further study is recommended, and immediate actions to rectify
      current social service deficiencies are cited.

PMID- 1019805
TI  - Social work and liaison psychiatry.
AB  - The Liaison Team of the Department of Psychiatry at Cook County Hospital uses a
      generic, multidisciplinary, crisis intervention approach to mental health
      consultation to facilitate humane and comprehensive yet cost-effective care for
      the medically indigent. Social work functions on the team include diagnosis,
      short-term individual and group treatment, referral, follow-up, staff
      development, in-service training, program planning, and interdisciplinary
      clinical instruction.

PMID- 1019806
TI  - Social work in a pediatric primary health care team in a group practice program.
AB  - The inclusion of a psychiatric social worker as a member of a pediatric team in a
      prepaid group practice extends the range of pediatric mental health services to
      children. This paper discusses the collaboration of the social worker with the
      pediatricians and allied health personnel on the team in dealing with the
      emotional problems of referred children and their parents. Case examples are
      included. All cases seen by the social worker during a 6-month period are
      reviewed. With available psychiatric backup a wide range of emotional problems
      are identified, and effective mental health care is provided.

PMID- 1019807
TI  - The doctor-relative relationship: an exercise in interview techniques in the
      "relatives' clinic".
AB  - The importance of the physician's relationship with the patient's relative is
      discussed, and the content of a series of interviews with relatives is analyzed.
      Their significance in adding to the doctor's knowledge of the patient is
      delineated.

PMID- 1019808
TI  - Public accountability, quality assurance and social work.
AB  - The growing demand for public accountability and quality assurance mechanisms
      affords the social work profession an opportunity to take a more forceful hand in
      the shaping of the health care delivery system. This paper surveys the impact of
      public accountability developments on the practice of social work in the health
      care fields, analyzes what has been done in social work qualtiy assurance, and
      suggests some strategies for enlarging the scope of social work to include
      productive new endeavors. Emphasis is placed upon resolution of the conflict
      between medical and human service treatment models.

PMID- 1019809
TI  - Improving the effectiveness of program consultation.
AB  - In a recent project concerned with the evaluation of consultation, experienced
      health program consultants demonstrated difficulty in two areas: (a) integrating
      mutnd (b) setting objectives and specifying criteria by which to measure
      attainment of those objectives. This paper outlines the purposes of this project,
      its background and methodology, and discusses in depth the areas of concern.
      Through an exploration of these issues in program consultation evaluation, health
      professionals can understand and hopefully improve their skills in this important
      area of functioning.

PMID- 1019810
TI  - Social work and genetic counseling.
AB  - Genetic counselors often impart anxiety-producing information to the patient and
      his family. A social worker should be available to help these individuals deal
      with the emotional impact of the genetic facts given them. Areas of concentration
      for the social worker in the genetics setting include aid in family planning,
      identification of psychosocial aspects of genetic disorders, and help in
      interpreting and understanding the genetic diagnosis and medical recommendations.
      The individual who discovers he possesses or transmits a defective gene needs
      help in improving his self-image and in relieving his guilt load.

PMID- 1019811
TI  - Group work with emphysema patients.
AB  - This article describes group work services to ambulatory emphysema patients in a
      community hospital. The group is viewed as an essential component in the
      treatment of patients with a chronically disabling illness. These patients
      experience devastating changes in their lives in the community, in the world of
      work, and in their families. Physical and respiratory therapy and medication
      comprise the medical treatment, group work provides the peer support necessary
      for coping with the disease in a way as to assist with maintaining health and
      improving the quality of life.

PMID- 1019812
TI  - Potential partners: attitudes of family practice residents toward collaboration
      with social workers in their future practices.
AB  - The study examines attitudes of family practice residents toward social work
      collaboration in their practices. Residents valued social work services highly,
      and almost three-fourths want a social worker in practice with them. Residents
      valued the broad range of services offered by social workers, and over half could
      see no disadvantages to such collaboration.

PMID- 1019813
TI  - Social work fees in medical care: a review of the literature and report of a
      survey.
AB  - This paper is based on a study undertaken to determine the advisability of
      establishing fees for social work service in a Family Practice Residency Program
      as a way of providing a funding base to assure continuing this professional
      service in the model Family Practice Unit at the University of Washington; and as
      a way of providing social worker services in other medical clinics.

PMID- 1019814
TI  - Staffing patterns: issues and program implications for health care agencies.
AB  - Unsolved staffing pattern issues are viewed in the current context of funding
      pressures, third party payment, and management necessity for program and cost
      projections. Relevant factors are mustered for consideration with their
      implications. Use of differentiated skill levels and response as well as
      development of departmental services mandate are considered. The author also
      shares his experientially derived thoughts on staff ratio to certain
      institutional assignments.

PMID- 1019815
TI  - Social science, social work and pharmacy.
AB  - In an effort to make pharmacy a more patient oriented health profession, pharmacy
      students at the University of Pittsburgh are required to take a course entitled,
      Social Sciences in Pharmacy. Besides drawing from the diverse social and
      behavioral sciences this course also includes material from the field of social
      work. This article describes the course and the students' reactions to it. It
      also provides an overview of some of the recent trends in the field and suggests
      areas where consultation between pharmacist and social worker may be indicated.

PMID- 1019816
TI  - Are fluorocarbon emulsions useful blood substitutes.

PMID- 1019817
TI  - Studies in patients with metastatic breast carcinoma treated with
      aminoglutethimide for medical adrenalectomy.

PMID- 1019818
TI  - Improved survival in endotoxemia with aspirin and indomethacin pretreatment.

PMID- 1019819
TI  - Effect of fine--needle biopsy, incisional biopsy, and palpation on experimental
      metastasis formation.

PMID- 1019820
TI  - L-asparaginase bound to collagen membrane in an extracorporeal device: an
      intermittent antitumor enzyme therapy delivery system.

PMID- 1019821
TI  - Role of polymorphonuclear leukocytes in host defense mechanism against cancer.

PMID- 1019822
TI  - Total body hyperthermia and preliminary results in human neoplasms.
AB  - We believe the hyperthermia is an effective adjunct to current modes of cancer
      therapy and warrants further study. The method described is safe and effective in
      achieving controlled total body hyperthermia. Monitoring techniques and life
      support measure are discussed. Limits of tolerance in humans are defined in this
      series as 41.8 C for 5 hr and 42 C (108F) for 2 hr, with the heart and liver as
      the limiting organs.

PMID- 1019823
TI  - Isolation regional prefusion: an experimental study.

PMID- 1019824
TI  - Immunocompetence measured by antibody--dependent cell--mediated cytotoxicity in
      surgical patients.

PMID- 1019825
TI  - Immunotherapy in treatment of anal condyloma acuminatum.

PMID- 1019826
TI  - The ileal loop: a novel approach to study of lymphoid depletion mediated by
      urine.

PMID- 1019827
TI  - Reversal of ischemically induced uncoupled oxidative phosphorylation by
      restoration of adequate perfusion.

PMID- 1019828
TI  - Thiabendazole: a new immunopotentiator effective in therapy of murine
      fibrosarcoma.

PMID- 1019829
TI  - Inhibition of tumor growth by glucan, a nonspecific immunostimulant.

PMID- 1019830
TI  - Enhancement of tumor growth by dinitrochlorobenzene (DNCB).

PMID- 1019831
TI  - Effect of various thyroid states on immunity.

PMID- 1019832
TI  - The immunostimulant Corynibacterium parvum and hematopoietic toxicity of
      chemotherapy.

PMID- 1019833
TI  - Unique features of serially transplanted human pancreatic cancer in nude mice.

PMID- 1019834
TI  - Local vs systemic factors in control of tumor inocula.

PMID- 1019835
TI  - Adjuvant immunochemotherapy of murine neoplasms.

PMID- 1019836
TI  - BCG immunotherapy: effects of dose and route of administration in mice bearing
      established tumors.

PMID- 1019837
TI  - Inhibition of tumor growth by metyrapone and desoxycorticosterone.

PMID- 1019838
TI  - Synergistic lymphocyte stimulation to tumor--specific antigens after immunization
      with modified tumor cells.

PMID- 1019839
TI  - Role of tumor angiogenesis factor in maintenance of tumor-induced vessels.

PMID- 1019840
TI  - Role of macrophages in would healing.

PMID- 1019841
TI  - Increased reliability of cellular immune assays with cryopreserved lymphocytes:
      studies in humans.

PMID- 1019842
TI  - Influence of heparin and isoproterenol on ventilation and perfusion following
      pulmonary embolism.

PMID- 1019843
TI  - Physiological dead space and arterial oxygenation following pulmonary artery
      occlusion in patients post trauma.

PMID- 1019844
TI  - Effect of colloid osmotic pressure and pulmonary capillary wedge pressure on
      intrapulmonary shunt.

PMID- 1019845
TI  - Effects of hepatic autologous lysosomal enzymes on rat lungs.

PMID- 1019846
TI  - Intravascular platelet neutrophil aggregation in staging of posttraumatic
      pulmonary insufficiency.

PMID- 1019847
TI  - Effect of O2 tension on microbicidal function of leukocytes in wounds and in
      vitro.

PMID- 1019848
TI  - Pulmonary changes of hemorrhagic shock with normotensive cephalic perfusion.

PMID- 1019849
TI  - Effect of prostaglandin E-1 on the lung in hemorrhagic shock.

PMID- 1019850
TI  - A pulse technique for measuring compliance of the lung.

PMID- 1019851
TI  - Endobronchial cryotherapy in treatment of tracheal strictures.

PMID- 1019852
TI  - Pulmonary vascular response to nitroprusside and dipyridamole.

PMID- 1019853
TI  - Prevention of pulmonary insufficiency by prophylactic use of PEEP and rapid
      respiratory rates.

PMID- 1019854
TI  - Fibrinogen 131I scans for detection of experimental absesses.

PMID- 1019855
TI  - Acute respiratory insufficiency: mechanisms of improving oxygenation by partial
      cardiopulmonary bypass.

PMID- 1019856
TI  - Acute arterial ulcer detection with radionuclide particles.

PMID- 1019857
TI  - Failure of aortic cross-clamping to cause renal cortical blood flow
      redistribution and increased renin release.

PMID- 1019858
TI  - Mismatch of mechanical properties as a cause of arterial prostheses thrombosis.

PMID- 1019859
TI  - Correlation of endothelial damage with fibrinogen 125I accumulation in arteries.

PMID- 1019860
TI  - Effect of steroids and immunosuppression on anastomotic intimal hyperplasia in
      femoral arterial bypass grafts.

PMID- 1019861
TI  - Effect of hypothermia, hemodilution, and pump oxygenation on organ water content
      and blood flow.

PMID- 1019862
TI  - Fibrinolytic treatment of acute or subacute arterial thrombosis.

PMID- 1019863
TI  - Prevention of endotoxin--induced irreversible platelet aggregation in vitro.

PMID- 1019864
TI  - Effects of intra-aortic balloon assistance on plasma catecholamines after
      myocardial infarction.

PMID- 1019865
TI  - Mannitol and intra--aortic balloon pumping as interventions to reduce myocardial
      infarct size.

PMID- 1019866
TI  - Direct vs balloon counterpulsation assistance of the failing myocardium.

PMID- 1019867
TI  - Methylprednisolone and regional myocardial blood flow during acute coronary
      occlusion.

PMID- 1019868
TI  - Optimal myocardial hypothermia at 10 to 15 c.

PMID- 1019869
TI  - Effect of hemodilution and profound hypothermic circulatory arrest on blood flow
      and oxygen consumption of the brain.

PMID- 1019870
TI  - Effects of ischemia on left ventricular regional function in conscious dogs.

PMID- 1019871
TI  - Myocardial preservation with glucose-insulin-potassium (GIK) and steroids during
      anoxic arrest.

PMID- 1019872
TI  - Arteriovenous shunting in the canine hindlimb with sepsis.

PMID- 1019873
TI  - Intermittent infusion of cardioplegic solution during aortic cross-clamping.

PMID- 1019874
TI  - Citrate reperfusion of ischemic heart in cardiopulmonary bypass.

PMID- 1019875
TI  - Effects of steroid pretreatment on LV blood flow, compliance, and performance
      after hypothermic ischemic arrest.

PMID- 1019876
TI  - Myocardial ischemia distal to critical coronary stenosis during cardiopulmonary
      bypass: fibrillating vs beating nonworking heart.

PMID- 1019877
TI  - Effects of increasing pacemaker sensing circuit impedance on R-wave detection.

PMID- 1019878
TI  - Radionuclide assessment of left ventricular function following cardiac surgery.

PMID- 1019879
TI  - Coronary blood flow and metabolism in dogs without tricuspid valve, with and
      without right ventricular hypertension.

PMID- 1019880
TI  - Does potassium-chloride-induced cardiac arrest protect the myocardium during
      aortic cross-clamping?

PMID- 1019881
TI  - Body composition following heart valve replacement.

PMID- 1019882
TI  - Neutrophil chemotaxis in surgical patients: effect of cardiopulmonary bypass.

PMID- 1019883
TI  - Distribution of renal blood flow after furosemide in critically ill patients.

PMID- 1019884
TI  - Dopamine vs epinephrine in patients following cardiac surgery: randomized study.

PMID- 1019885
TI  - An experimental evaluation of coronary air embolism.

PMID- 1019886
TI  - An experimental model of cardiomyopathy.

PMID- 1019887
TI  - Graded venous hypertension as a potentiator of ischemic myocardial injury.

PMID- 1019888
TI  - Simplified in vivo measurement of diastolic compliance of the left ventricle.

PMID- 1019889
TI  - Effects of cardiopulmonary bypass on neutrophil chemotaxis.

PMID- 1019890
TI  - Septic cardiomyopathy: physiology of left ventricular failure.

PMID- 1019891
TI  - Effects of glucagon on renal function in protein--deprived rats.

PMID- 1019892
TI  - Totally implantable diaphragm pacemaker: experimental studies.

PMID- 1019893
TI  - Myocardial contusion: diagnostic value of cardiac scanning and echocardiography.

PMID- 1019894
TI  - Physiologic function of transplanted parathyroid glands in man.

PMID- 1019895
TI  - Endogenous fuels in experimental shock.

PMID- 1019896
TI  - Isolation and biological characterization of rat histocompatibility antigens.

PMID- 1019897
TI  - Effects of glucose and alanine on energy metabolism in hemorrhagic shock.

PMID- 1019898
TI  - Depressed cellular immunity in diabetics.

PMID- 1019899
TI  - Interference with testicular development by delta 9 tetrahydrocannabinol.

PMID- 1019900
TI  - Mechanism of elevated cerebral serotonin concentration associated with acute
      hepatic ischemia.

PMID- 1019901
TI  - Regulation of liver regeneration by the pancreas in dogs.

PMID- 1019903
TI  - Hepatotrophic activity in nonpancreatic, nonduodenal portal blood.

PMID- 1019902
TI  - Pancreas extract and liver regeneration.

PMID- 1019904
TI  - Hepatic blood flow and pancreatic hormones as modifiers of hepatic regeneration.

PMID- 1019905
TI  - Wound healing in partially hepatectomized rats and effect of their serum on
      fibroblast growth in vitro.

PMID- 1019906
TI  - Insulinase in liver cirrhosis.

PMID- 1019907
TI  - Nitrogen--sparing in normal man:effect of glycerol and amino acids given
      peripherally.

PMID- 1019908
TI  - Early hemodynamic effects of the distal splenorenal shunt.

PMID- 1019909
TI  - Effect of portacaval shunt on rat serum lipids, lecithin cholesterol
      acyltransferase, and lipoproteins.

PMID- 1019910
TI  - Bile acid alterations in patients with cholesterol gallstones.

PMID- 1019911
TI  - Response of the distal esophageal sphincter to respiratory and positional
      maneuvers in humans.

PMID- 1019912
TI  - Bicarbonate perfusion and lower esophageal sphincter response to pentagastrin.

PMID- 1019913
TI  - Effect of glucose on the nitrogen--sparing effect of amino acids given
      intravenously.

PMID- 1019914
TI  - Vagal stimulation of canine duodenal motor activity.

PMID- 1019915
TI  - Prostaglandin E2 prevents aspirin and indomethacin damage to human gastric
      mucosa.

PMID- 1019916
TI  - Effect of the E2 prostaglandins on gastric mucus production in rats.

PMID- 1019917
TI  - Normal structure--function relationships in gastric microcirculation and changes
      in experimental stress ulceration.

PMID- 1019918
TI  - Stimulation of gastrin secretion by parathyroid hormone.

PMID- 1019919
TI  - Patterns of molecular forms of gastrin in antral mucosa and antral serum.

PMID- 1019920
TI  - Chronic hypergastrinemia produces hypertrophy of the liver and intestine in rats.

PMID- 1019921
TI  - Effect of bombesin on serum gastrin and cholecystokinin in dogs.

PMID- 1019922
TI  - Gastric autoantibody and serum gastrin in achlorhydric states.

PMID- 1019923
TI  - Adverse effects of elemental diets on tolerance for fluorouracil (5-fu) toxicity
      in rats.

PMID- 1019924
TI  - Gastrin cell hyperplasia induced by corticosteroids.

PMID- 1019925
TI  - Effect of prostaglandin E1 on plasma secretin and pancreatic exocrine function in
      dogs.

PMID- 1019926
TI  - Determination of secretin levels in mucosa by radiommunoassay.

PMID- 1019927
TI  - Metabolic significance of skeletal muscle during normal and shock conditions.

PMID- 1019928
TI  - Cholecystokinin, a new hypocalcemic agent.

PMID- 1019929
TI  - The placenta as a possible source of gut peptide hormones.

PMID- 1019930
TI  - Active bicarbonate secretion by mammalian antrum.

PMID- 1019931
TI  - Early proliferative activity in the left colon of the rat after partial small-
      bowel resection.

PMID- 1019932
TI  - Effect of bile acids on hepatic cholesterol synthesis in partial ileal bypass in
      rabbits.

PMID- 1019933
TI  - Small--intestinal bypass in nutritionally obese rats receiving choline
      supplement.

PMID- 1019934
TI  - Origin of regeneration factor.

PMID- 1019935
TI  - Action of insulin inhibitors on exocrine pancreatic secretion of the rat with
      chronic pancreatic fistula.

PMID- 1019936
TI  - Duodenal reflux into the pancreatic duct in dogs.

PMID- 1019937
TI  - Development of an animal model of pancreatic cancer.

PMID- 1019939
TI  - Delivery of surgical care: inferences based on hospital discharge abstract data.

PMID- 1019938
TI  - Anticoagulation in the treatment of experimental peritonitis.

PMID- 1019940
TI  - Microsurgical anatomy of anterior cerebral anterior communicating recurrent
      artery complex.

PMID- 1019941
TI  - Spinal cord deformation velocity, impulse, and energy related to lesion volume in
      "standardized" trauma.

PMID- 1019942
TI  - Hemorrhagic pulmonary edema following stereotactic hypothalamic lesions in dogs.

PMID- 1019943
TI  - Dynamics of capillary permeability in cerebral edema.

PMID- 1019944
TI  - Time course of brain tissue pressure and compartmental CSF pressure in cerebral
      edema.

PMID- 1019945
TI  - Effect of dexamethasone on the brain edema of cranial impact.

PMID- 1019946
TI  - Threshold loaded CO2 response curves: a new method for evaluating breathing in
      neurosurgical patients.

PMID- 1019947
TI  - Experimental selective middle cerebral artery stroke model.

PMID- 1019948
TI  - Experimental middle cerebral artery microsurgical embolectomy.

PMID- 1019949
TI  - Cerebral effects of barbiturate: shift from "energy" to synthesis metabolism for
      cellular viability.

PMID- 1019950
TI  - Cerebral hemodynamics: effect of mannitol on the cerebral perfusion gradient.

PMID- 1019951
TI  - The nitroblue tetrazolium (NBT) test in evaluation of postoperative fever.

PMID- 1019952
TI  - Regional cerebral blood flow: intravenous injection technique.

PMID- 1019953
TI  - Preliminary observations on the weight-bearing surfaces of the human ankle joint.

PMID- 1019954
TI  - Rotational axis of the ankle joint: comparison of normal and pathologic states.

PMID- 1019955
TI  - Effects of ligamentous injury on ankle and subtalar joints: a kinematic study.

PMID- 1019956
TI  - In vitro strain patterns in "intertrochanteric fractures" internally fixed with
      nail-plate or compression screw-plate.

PMID- 1019957
TI  - Pathologic fractures of femoral shaft: study of internal fixation techniques
      incorporating methylmethacrylate.

PMID- 1019958
TI  - Etiology of fat embolism syndrome: early morphologic lung changes of respiratory
      distress syndrome produced by triolein.

PMID- 1019959
TI  - The biophysical properties of methylmethacrylate: effects of radiation and other
      parameters.

PMID- 1019960
TI  - Patterns of mineralization in forming membrane bone.

PMID- 1019962
TI  - The hypertension of femoral lengthening: a canine experimental model.

PMID- 1019961
TI  - Cortical bone atrophy secondary to compression plate fixation: a clinical and
      pathophysiologic study.

PMID- 1019963
TI  - Experimental chronic hematogenous osteomyelitis.

PMID- 1019964
TI  - Serum, muscle, and bone levels of intravenous, intra-arterial, and regional
      cephalothin perfusion.

PMID- 1019965
TI  - Induction of collagen synthesis in rats by transplantation of allogenic
      macrophages.

PMID- 1019966
TI  - Hearing loss, renal disease, and cochlear strial deposits.

PMID- 1019967
TI  - Control characteristics of the normal human in quiet standing.

PMID- 1019968
TI  - Alteration of pulmonary function associated with artificial nasal obstruction.

PMID- 1019969
TI  - Effect of radiotherapy on aerobic and anaerobic isolates in hemovac lines.

PMID- 1019970
TI  - Teratomas of the head and neck.

PMID- 1019971
TI  - Microsurgical anatomy of the optic canal: anatomical relations and exposure of
      the optic nerve.

PMID- 1019972
TI  - Deep ocular socket reconstruction.

PMID- 1019973
TI  - Maxillectomy with preservation of orbital function.

PMID- 1019974
TI  - Systemic and regional arteriovenous shunting in endotoxic and septic shock in
      dogs.

PMID- 1019975
TI  - A new collagen sponge to dress open wounds.

PMID- 1019977
TI  - The periosteum and craniofacial growth.

PMID- 1019976
TI  - Calcium-related cutaneous necrosis.

PMID- 1019978
TI  - Altered polymorphonuclear leukocyte bioenergetics in patients with thermal
      injury.

PMID- 1019979
TI  - Prolonged ischemia in the replanted rat leg: a biochemical and morphologic study
      with microvascular techniques.

PMID- 1019980
TI  - Effects of mobilization on partially lacerated tendons.

PMID- 1019981
TI  - Quality of tendon graft healing in silastic pseudosheaths: breaking-strength
      studies.

PMID- 1019982
TI  - Immune "save" of lethally irradiated mice with use of allogeneic spleen cells.

PMID- 1019983
TI  - Continuous monitoring of in vivo oxygen tension with a fuel cell.

PMID- 1019984
TI  - Androgenic effects of testosterone and dihydrotestosterone applied topically to
      the rat phallus.

PMID- 1019985
TI  - Dose-related effect of testosterone, dihydrotestosterone, and cyproterone acetate
      on male organ weights.

PMID- 1019986
TI  - Renal air embolism: an unrecognized cause of organ failure.

PMID- 1019987
TI  - Response to chemically induced prostatic tumors in rats to stilbestrol and
      orchiectomy.

PMID- 1019988
TI  - Spontaneously occurring renal adenocarcinoma in balb c/cr mice: electron
      microscopic observations.

PMID- 1019989
TI  - An in vivo model system of human bladder cancer.

PMID- 1019990
TI  - Bladder adherence to urothelium.

PMID- 1019991
TI  - Effect of distention on vesical blood flow.

PMID- 1019992
TI  - High-dose glucose-insulin-potassium in treatment of irreversible hemorrhagic
      shock.

PMID- 1019993
TI  - Prostatic fluid and extract from prostate inhibit macrophages.

PMID- 1019994
TI  - Improvement of oxygen--carrying properties of stoma--free hemoglobin solution
      with acetrizoate sodium.

PMID- 1019995
TI  - Pulmonary and systemic capillary permeability to protein following endotoxin.

PMID- 1019996
TI  - Antibiotic bowel preparation and burn wound colonization.

PMID- 1019997
TI  - Role of branched chain amino acids (BCAA) intake in preventing muscle
      proteolysis.

PMID- 1019998
TI  - Erythropoietin elevation in anemia of thermal injury.

PMID- 1019999
TI  - Jejunoileal bypass, liver morphology, and intestinal microflora in conventional
      and germfree dogs.

PMID- 1020000
TI  - Cholesterol metabolism after portacaval shunt and partial ileal bypass in
      rabbits.

PMID- 1020001
TI  - Effect of total portal and intestinal venous diversion of dietary hyperlipidemia.

PMID- 1020002
TI  - Hyperparathyroidism during pregnancy and neonatal hypocalcemia.

PMID- 1020003
TI  - Functional activity of a gonadotrophin--producing human lung carcinoma after
      transplantation in nude mice.

PMID- 1020004
TI  - Elevated immunoglobulins in bronchial washings of patients with lung cancer.

PMID- 1020005
TI  - Safe use of vincristine following partial hepatectomy.

PMID- 1020006
TI  - Effect of surgery on antitumor immunity measured by tube leukocyte adherence
      inhibition assay in breast cancer.

PMID- 1020007
TI  - Diagnostic accuracy of thermography in breast cancer screening: effect of
      examination sequence.

PMID- 1020008
TI  - Treatment of breast cancer with danazol.

PMID- 1020009
TI  - Immunologic diagnosis of breast cancer.

PMID- 1020010
TI  - Estrogen-receptor movement to the nucleus: discussion of a cytoplasmic-exclusion
      hypothesis.

PMID- 1020012
TI  - [Evil mother automobile. The psychoanalysis of an everyday relationship].

PMID- 1020011
TI  - Investigation of the mechanisms and consequences of steroid hormone action on
      vitellogenin synthesis in Xenopus laevis.

PMID- 1020013
TI  - [Effects and side effects of topically applied glucocorticosteroids in
      dermatotherapy].

PMID- 1020014
TI  - [Emergency situations in general practice].

PMID- 1020015
TI  - [Epidemiology of health conditions among the Shuara Indians in Ecuador].

PMID- 1020016
TI  - [Material security for women doctors].

PMID- 1020017
TI  - Light and dark adaptational changes in the accessory eye of the shrimp,
      Palaemonetes.
AB  - The fine structure of the accessory eye of the shrimp, Palaemonetes, was studied
      after light and dark adaptation. Adjacent to the principal compound eye, the
      accessory eye is a small compound eye composed of about 20 ommatidia which are
      smaller in structure to the ommatidia of the principal compound eye. During dark
      adaptation, rhabdomal microvilli increase in length; however, little pigment
      migration occurs. The implications of these changes in relation to the function
      of the accessory eye are discussed.

PMID- 1020018
TI  - Quantitative and comparative ultrastructure of the vertebrate cornea. I. Urodele
      Amphibia.
AB  - The cornea of the urodele amphibian Triturus c. cristatus was studied
      ultrastructurally in order to provide the basis for a comparison among corneas
      throughout the vertebrate phylum. The cornea of this salamander consists of
      relatively thick epithelium and basement membrane and thin Descemet's membrane,
      unlike the mammalian corneas. The outermost epithelial cells contain Ruthenium
      Red stainable extracellular filaments and intracellular vesicles which are
      thought to play a role in the process of lubricating the corneal surface.
      Occluding junctions have been observed in the apical region of the superficial
      epithelial cells and are considered as barriers to the intercellular passage of
      material. A thin substantia propria (stroma) consists of about 40 collagenous
      highly organized lamellae. The thicknesses of the basement membrane, Descemet's
      membrane and the epithelium are believed to represent the primitive situation in
      the process of corneal evolution.

PMID- 1020019
TI  - Quantitative changes and ultrastructural alterations of the cornea in response to
      ultraviolet light. II. Effects of amphibia; elucidation of desmosomal structure
      and basement membrane synthesis.
AB  - The effects of far ultraviolet light irradiation upon an amphibian cornea were
      studied to compare the effects observed both quantitatively and ultrastructurally
      with data obtained after UV irradiation of mammalian corneas. The ultimate goal
      of this series of investigations is the elucidation of the alterations and the
      regeneration mechanisms, which might reflect existing morphological diversities
      among the species, observed in vertebrate corneas following exposure to UV light.
      It was found that while the epithelial cells undergo oedema after low dose
      exposures and are gradually damaged after high doses of UV light, 2-4 days leter
      a new epithelium has been formed. Intercellular permeability is increased by low
      dose exposure as was detected by the penetration of Ruthenium Red into the
      intercellular clefts. Under these conditions desmosomal structure revealed a 21
      laminar configuration. The basement membrane of the amphibian, unlike that of the
      mammal, does not dissolve away upon exposure but shows localized disruptions
      which are thought to accommodate the passage of leucocytes from stroma to
      epithelium. That a new basement membrane is subsequently formed is evident by the
      existence of extracellular and intracellular secretion granules. In comparison to
      irradiated rabbit corneas, this stroma remains remarkably at the same thickness
      following a high dose exposure although a noticeable disorganization of collagen
      arrangement is apparent. Finally, as in the case of the rabbit corneas, a
      secondary degeneration of endothelium was observed 4 days after a moderate dose
      exposure.

PMID- 1020020
TI  - Fine structure of the spermatozoon of an onychophoran, Peripatopsis.
AB  - The spermatozoon of the Onychophoran Peripatopsis moseleyi is described. This
      cell is characterized by the general filiform shape, the absence of an acrosome,
      the presence of mitochondrial derivatives, of an annulus and of nine accessory
      tubules and a manchette of microtubules around the axoneme. All of these
      characters are typical of highly evolved sperm models, like those of insects and
      mammals, and suggest a long evolutionary history. Only the position of the
      mitochondria, inserted between nucelus and axoneme, is reminiscent of annelid
      features.

PMID- 1020021
TI  - The morphology of regeneration of skeletal muscles in the rat.
AB  - Muscle regeneration was studied by light and electron microscopy in soleus
      muscles of rat. After segmental crushing the number of fibres increased in some
      muscles within 30 days, indicating that numerical hyperplasia can take place.
      Locally applied Ringer solution of 60-70 degrees C caused necrosis of myofibres
      but left satellite cells and blood supply largely intact. Following phagocytosis,
      four mechanisms of regeneration were seen. (1) Lost fibres were replaced by
      clusters of myotubes formed by satellite cells within persisting basal lamina
      tubes. These clusters displaced the surrounding endomysium and looked like
      longitudinally 'split' fibres. (2) Viable fibre fragments fused with satellite
      cells. (3) Satellite cells of surviving fibres proliferated and fused to myotubes
      localized beneath the basal lamina. (4) Thin new fibres occurred in the
      interstitium. Their origin remained unknown. After 6 months the mean size of the
      new myofibres was normal, but the scatter of diameters was increased, central
      nuclei, fibre 'spliting' and branching, and fibrosis were prominent. Staining for
      acetylcholinesterase revealed that many fibres were short and not innervated. The
      similarity with dystrophic muscles in man suggested, that the most prominent
      histological changes in myopathic muscles may be due to attempts of regeneration.

PMID- 1020022
TI  - The investigation of vinylcyclohexane dioxide as a polar dehydrant for the
      improved retention of lipids in the Spurr embedment.
AB  - The use of vinylcyclohexane dioxide (VCD) as a polar dehydrant with subsequent
      embedment in Spurr was studied. The utilization of Epon 812 resin (E 812),
      hydroxyethyl methacrylate (HEM) and hydroxypropyl methacrylate (HPM) as polar
      dehydrants for Epon embedment were re-examined, and a polar Epon mix was
      introduced. The most effective dehydration sequence was: first 90%, then 95% VCD
      in water for 5 min. followed by two 20 min changes of 100% VCD. After 1 hr in
      equal quantities of VCD and Spurr mix, tissues were infiltrated with Spurr
      embedment (two 1 hr changes and overnight) and finally embedded in Spurr and
      polymerized at 60 degrees C for 16 hr. The most utilizable polar Epon mix was
      determined to be Epon 812 = 50 ml, NMA=42 ml, DMP-30=1-2 ml. It was somewhat
      brittle but cut well with both glass and diamond knives. All four polar
      dehydrants were found to retain lipids and carbohydrates equally well in thin
      section in striated and cardiac muscle, liver, kidney and brain from the rat. The
      E 812 was the only dehydrant that retained lung multilamellar bodies. The
      possible carcinogenic effects of VCD were considered and the probably metabolism
      and excretion of VCD were discussed.

PMID- 1020023
TI  - Hyperinsulinemia: effects on body weight, obesity and motivated behaviors.
AB  - Five experiments were performed to evaluate the physiological and behavioral
      similarities between lesions of the ventromedial hypothalamus (VMH) and injection
      produced hyperinsulinemia. It was found that the rate of weight gain and fat
      deposition in both adult and weanling rats was essentially the same for both VMH
      and hyperinsulinemic rats. Measures of activity and taste preference measures
      yielded no differences between hyperinsulinemic rats and intact rats. Electric
      shock thresholds revealed a decrease in reactivity for hyperinsulinemic rats
      compared to intact rats. A hypothesis was suggested in which a combination of
      hypophysectomy, gonadectomy, and hyperinsulinemia might produce most of the
      physiological effects seen with VMH lesions. It was also suggested that since
      these physiological alterations radically modify the organism's internal
      environment, the behavioral effects of VMH lesions may be the results of the
      attempts of a brain-damaged animal to maintain new physiological conditions.

PMID- 1020024
TI  - 'Self-correcting' spherical bioelectrode.
AB  - Most of the widely used biopotential macroscopic and microscopic bioelectrodes do
      not enable proper measurements while in contact with 'problematic' tissues, such
      as myocardial and other muscular tissues, cortical and intracavital tissues. A
      quantitative spherical electrode was designed as an example in the family of
      bioelectrodes enabling application in moving or vibrating media. The electrode
      developed is insensitive to its contact area. Decreasing the contact area to 40%
      causes 25% increase in measured resistance only. The electrode shows excellent
      performance in alternating current conditions combined with well-defined direct
      current characteristics.

PMID- 1020025
TI  - [Experience with the use of programmed control and the index of operativeness of
      the control system in the learning process].

PMID- 1020026
TI  - [Method of calculating stresses resulting in traumatic intervertebral disk
      rupture].

PMID- 1020027
TI  - [Forensic medical expertise in injuries with the diagnostic "cerebral concussion"
      in persons with pre-existing diseases of the CNS].

PMID- 1020028
TI  - [Determination of potassium ion activity in blood in order to determine recent
      occurrence of death].

PMID- 1020029
TI  - [Forensic-chemical proof of eunoctin poisoning].

PMID- 1020030
TI  - [Isolation of trichlormetaphos from biological material by distillation with
      water vapor].

PMID- 1020031
TI  - [Problems and prospects for forensic medicine in the 10th five-year-plan].

PMID- 1020032
TI  - [Isolation of fluorides from the liver by destruction with subsequent
      determination].

PMID- 1020033
TI  - [Immune rabbit sera precipitating deer blood proteins. Use in forensic medicine].

PMID- 1020034
TI  - [Xg blood system--genetics, distribution, forensic-medical and clinical
      significance (review of the literature)].

PMID- 1020035
TI  - [Induced psychosis ending in suicide].

PMID- 1020037
TI  - [Scale microphotography in physico-chemical studies].

PMID- 1020036
TI  - [Determining the exposure and depth of sharply represented space in
      macrophotographs of medico-legal objects].

PMID- 1020038
TI  - [Injuries by the claws and teeth of a bear].

PMID- 1020039
TI  - [Beroxan and sunburn].

PMID- 1020040
TI  - [Penetration of a stone into the cranial cavity].

PMID- 1020041
TI  - [Impression of the barrel-end in a hand-gun wound].

PMID- 1020042
TI  - [Forensic stomatology as a division of forensic medicine].

PMID- 1020043
TI  - Nuclear glycogenosis and virus-like particles in human laryngeal papilloma cells.

PMID- 1020044
TI  - Adriamycin plus cyclophosphamide in advanced bronchial carcinoma.
AB  - Adriamycin (40 mg/m2 i.v., on day 1) plus cyclophosphamide (200 mg/m2 orally, day
      1 to 5) were given to 23 patients with advanced lung cancer. Administration
      cycles were repeated every 3 weeks. No patient had been previously treated with
      chemotherapy, 5 received prior radiotherapy. Objective improvement was observed
      in 7 patients, partial remission was observed in 3. The median duration of
      response was 2 months.

PMID- 1020045
TI  - [Study of the geographical pathology of laryngeal, bladder and childhood tumors
      in the Province of Turin].
AB  - A previous report has shown that in the non-metropolitan areas of the province of
      Torino the incidence of cancer of the larynx in men during the period 1965-1969,
      although lower than in the town of Torino and its suburbs, was 3-6 times higher
      than in Great Britain, Norway, Sweden and Denmark. In the present study the
      distribution of these cancers was investigated in the 12 ecological areas and/or
      subareas forming the non-metropolitan areas of the province. A similar study for
      bladder cancer in adult men and all cancers (including leukaemias) in children,
      is also reported. In subareas 36, 37 and 42 of ecological area 01 (i.e., located
      NW of the capital and its suburbs) as well as in area 02 (located North of the
      province, around the town of Ivrea) a significant excess of laryngeal cancers
      have been diagnosed in adult men during the period 1965-1969. Cancer of the
      bladder was found in excess in men residing in subareas 37 and 43 of area 01
      (geographically related to the town of Cirie, where an epidemic of bladder cancer
      was recognized among workers of a chemical factory where 2-naphthylamine and
      benzidine have been widely used in the past), as well as in men residing in area
      02. In addition, laryngeal cancer was found in excess among residents in
      Balangero (where a large asbestos-chrysotilemine has been in operation for a long
      time) and adjacent towns (observed 12, expected 5.14, p less than 0.01). Bladder
      cancer was particularly frequent among residents in Cirie and adjacent towns (19
      cases vs. 9.18 expected, p less than 0.01) as well as in those residing in Ivrea
      and adjacent towns (24 vs. 14.61 expected, p less than 0.02). On the contrary,
      the whole area situated East and South of Torino and its suburbs seems to be a
      low-incidence area for both laryngeal and bladder cancer. For both tumor types
      the highest incidence was found in the town of Torino. Men residing in the 23
      suburbs of Torino showed a high incidence of laryngeal cancer and a low incidence
      of bladder cancer. Cancers in children were fairly uniformly distributed
      throughout the whole province, including the capital.

PMID- 1020046
TI  - Hysterosalpingography in the sequels of conisation of the uterine cervix.
AB  - A hysterosalpingographic survey was made of 65 women of reproductive age who had
      undergone conisation of the uterine cervix for carcinoma in situ or severe
      dysplasia at least one year before. None of the patients investigated
      radiologically had undergone uterine surgery before conisation. In a high
      percentage of cases morphological changes of the cervical canal and, less
      frequently, the isthmus were found. Most of the changes are attributable to scar
      retraction, and the hysterosalpingographic findings did not differ appreciably
      from those following other types of gynecological surgery, namely, segmental or
      total stenosis and ectasia of the cervical canal and isthmus. A control series of
      patients with preoperative and postoperative hysterosalpingograms is now under
      consideration to confirm the radiological findings and to correlate them with
      clinical data.

PMID- 1020047
TI  - [Clinical examination and 131 Cs scanning in the diagnosis of cold nodules of the
      thyroid (author's transl)].
AB  - The usefulness of 131Cs scanning in preoperative diagnosis of 131I cold nodules
      of the thyroid that present no clear clinical sign of malignancy is discussed.
      The results of clinical examination of 283 thyroid nodules, associated in 139
      cases with 131Cs scanning, are correlated with the histologic nature. In nodules
      that were classifided as cold, warm or hot in the 131Cs scan, the incidence of
      malignancy was 2.6, 12.3 and 25%, respectively. In the nodules that, on the basis
      of clinical examination, were classified as probably benign, dubious or suspected
      for malignancy, the incidence of cancer was, respectively, 3.6, 26.3 and 72.7%.
      Malignancy ocurred in 16 of 144 patients that were selected for surgical
      treatment only on the basis of clinical data and in 17 of 139 patients that were
      selected on the basis of clinical examination associated with 131Cs scanning. The
      accuracy of clinical preoperative diagnosis of thyroid cold nodules does not seem
      to be significantly improved by association of 131Cs scanning.

PMID- 1020048
TI  - Biological properties of cell lines derived from Moloney virus-induced sarcoma.
AB  - Two cell lines derived from a primary MSV-M-induced tumor in a BALB/c mouse were
      studied. One line (MS-2) was subject only to continuous tissue culture transfer
      (tct). After 21 tct, MS-2 cells produced progressive tumors (MS-2 tumors) in
      syngeneic hosts. The second cell line (MS-2T) was established by cultivation of a
      MS-2 tumor. The ability to produce progressive tumors decreased with increased
      number of tct, in both cell lines. The virus content of MS-2 and MS-2T cells was
      very low, as shown by uridine incorporation and electron microscopy.
      Immmunofluorescence tests demonstrated that antigens different from the viral MSV
      M antigens were present on the cell lines, and that antigenic changes occurred
      with increased number of tct. Serum of mice bearing progressive MS-2 tumors
      reacted with MS-2T cells when these cells produced progressive tumors and did not
      react with MS-2 cells when they produced regressing tumors. MS-2 cells producing
      regressing tumors reacted with serum from mice in which the MS-2 tumor had
      regressed and with serum from mice immunized with MS-2T cells at late tct when
      they were poorly oncogenic. The antigenic changes seemed, therefore, to parallel
      the decrease of malignancy. A chromosomal analysis carried out on MS-2 and MS-2T
      cells, when both produced progressive tumors, showed a modal number of 48 and 44,
      respectively. MS-2T cells showed a large acrocentric chromosome. In contrast, the
      MS-2 cells at late tct, when they gave regressing tumors, showed a modal number
      of 60 and a wide range of distribution of chromosome number.

PMID- 1020049
TI  - Skin tests in childhood lymphoma and neuroblastoma.
AB  - Intradermal skin test antigen (Varidase, Mumps, Candidine) and contact
      sensitization with 2,4-dinitrochlorobenzene (DNCB) were employed in 35 previously
      untreated children with neuroblastoma and malignant lymphoma, to evaluate delayed
      cutaneous hypersensitivity. Cutaneous responses were correlated to stage of
      disease and survival. The limited number of patients prevents any definitive
      conclusion. It is apparent, however, that in childhood non-Hodgkin's lymphoma
      anergy to DNCB is correlated to advanced stages with rapid progressive disease.
      In neuroblastoma and Hodgkin's disease patients skin test sensitization seems to
      be of questionable clinical value.

PMID- 1020050
TI  - [Controlled pilot study with combination chemotherapy in testicular carcinomas
      (author's transl)].
AB  - In 24 previously untreated patients with advanced testicular carcinoma, the
      combination of adriamycin, vincristine and methotrexate (AVM) was tested in a
      prospective randomized study against a combination of non-cross resistant drugs
      including vinblastine, bleomycin and mithramycin (VBM). Complete and partial
      (greater than 50%) remission was observed in 4 out of 13 patients treated with
      AVM and in 3 out of 11 given VBM. In one patient receiving AVM and in two
      patients treated with VBM, the response at the level of previous inoperable
      retroperitoneal metastatic lymph nodes allowed a subsequent radical lymph node
      dissection. After cross-over a partial response for 6 months was obtained in only
      one patient treated with VBM while none was observed in 4 patients receiving AVM.
      Both combinations were well tolerated. However, their therapeutic activity seems
      to be definitely lower with respect to treatment with vinblastine followed by
      continuous infusion with bleomycin.

PMID- 1020051
TI  - [Changes in the effect of some antineoplastic agents after erythropoietic
      stimulation].

PMID- 1020052
TI  - The importance of metastic cervical lymph nodes on the prognosis and therapy of
      malignant neoplasias of the head and neck.
AB  - The author in a study of 667 patients submitted to unilateral or bilateral
      radical neck dissection presents a critical analysis of clinical palpatory and
      histopathological methods in the evaluation of the metastatical lymph nodes in
      head and neck cancer. The advantages of the last one are pointed out showing the
      real prognostic value of the histopathological metastases.

PMID- 1020053
TI  - A case of cavernous haemangioma of the spleen.

PMID- 1020054
TI  - Myocardial injury induced by a single dose of adriamycin: an electron microscopic
      study.
AB  - Adriamycin cardiomyopathy has been studied under the electron microscope using
      myocardial ventircular cells of CRF mice, previously treated with 10 mg/kg body
      weight of the drug given in a single intravenous injection. Within 10 min
      myocardial cell nucleoli show a nucleolonema fragmentation, and during the
      following 3 hours they acquire the nucleolar segregation pattern. Fourteen hours
      after drug injection, nucleolar morphology again becomes normal, while areas of
      focal degeneration, characterized by damaged mitochondria and enlarged smooth
      reticulum cisternae, appear in the sarcoplasm. One to 3 days later the
      degeneration process involves the myofibrillar component, and after 50 days the
      great majority of myocardial ventricular cells is damaged. The early appearance
      and the functional significance of nucleolar segregation support the hypothesis
      that adriamycin cardiotoxicity might be dependent on its ability to bind to
      myocardial cell DNA. The consequent failure of RNA and protein synthesis,
      impairing the continuous renewal of myofibrillar and mitochondrial components of
      the cell, might explain the progressive myocardial damage.

PMID- 1020055
TI  - Ultrastructural changes produced in cultured, adriamycin-treated myocardial
      cells.
AB  - The ultrastructural evaluation of the early alterations adriamycin-induced on
      cultured mice heart cells is reported. The major effects are hypertrophy of the
      sarcoplasmic reticulum and a market increase of the number and total extension of
      the gap junctions. These findings are discussed in the light of the information
      available in the literature.

PMID- 1020056
TI  - [Familial osteopoikilosis in a diabetic].

PMID- 1020057
TI  - [Ota's nevus fuscoceruleus ophthalmomaxillaris with unilateral systemic
      angiomatosis].

PMID- 1020058
TI  - [Value of furosemide in the treatment of chronic terminal renal failure].

PMID- 1020059
TI  - [Tiered stenoses of the small intestine of tuberculous origin].

PMID- 1020060
TI  - [Disseminated lupus erythematosus. Apropos of 3 cases].

PMID- 1020061
TI  - [Horton's disease].

PMID- 1020062
TI  - [Ringworm of the scalp in the Hoggar (Algerian Sahara)].

PMID- 1020063
TI  - [Pulmonary silicosis in Tunisia. Apropos of 114 cases observed in 5 years (1971
      1975)].

PMID- 1020064
TI  - [Demographic statistics of the governorate of Nabeul collected by a
      representative sample of the population by demographic observation following
      multiple surveys].

PMID- 1020065
TI  - Trends in alloplastic replacement of segments of the urinary tract.

PMID- 1020066
TI  - ABH secretor status in patients with bladder tumours.
AB  - The ABO blood groups and secretor status of a group of patients with bladder
      tumours were investigated and compared with those of a group of patients of a
      similar age suffering from a variety of genito-urinary diseases. Some of the
      control patients were known to have been exposed to potential carcinogens, and
      the findings in this group were analysed separately. No significant differences
      were found when comparisons of these three groups of patients were made.

PMID- 1020067
TI  - Modifications of ureteric peristalsis by local anaesthetic. An experimental study
      in dogs.
AB  - An in vivo study of the response of the dog ureter to local anaesthetics
      administered systemically and by ureteric perfusion, revealed that lidocaine,
      procaine, and mepivacaine, caused hyperperistalsis. The intravenous use of a near
      toxic dose produced hyperperistalsis of limited duration, whereas, intraureteric
      administration produced a prolonged and constant response with low dosage. The
      mode of action of these drugs is unclear as they are generally regarded as being
      non specific smooth muscle depressants. Continued peristalsis after prolonged
      exposure to local anaesthetic favours a myogenic rather than neurogenic
      conduction of the ureteric contraction wave.

PMID- 1020068
TI  - Urinary oxalate in summer and winter in normal subjects and in stone-forming
      patients with idiopathic hypercalciuria, both untreated and treated with thiazide
      and/or cellulose phosphate.
AB  - Urinary oxalate excretion has been measured by a specific enzymatic method in
      normal subjects and stone formers with idiopathic hypercalciuria. In every group
      studied urinary oxalate was higher in the summer than in the winter. These
      differences were slight and not significant in normal subjects but were
      considerable and statistically significant in the stone formers both untreated
      and when treated with thiazide. Thiazides raise urinary oxalate only very
      slightly but cellulose phosphate leads to large rises in urinary oxalate both in
      the summer and the winter. The highest values of urinary oxalate were seen in the
      summer in patients treated with cellulose phosphate. The mean rise in this group
      was 70% above normal and this must be viewed with some anxiety.

PMID- 1020069
TI  - The pathogenesis and treatment of persistent epithelial defects.

PMID- 1020070
TI  - Iatrogenic breaks in Buuch's membrane in choroidal melanoma.
AB  - Three patients with choroidal melanoma have been observed to develop subretinal
      hemorrhages associated with their ocular examinations. One hemorrhage appears to
      have been caused by transillumination, while two others have occurred during
      radioactive phosphorus testing. Histopathology confirms defects in Bruch's
      membrane through which blood or tumor cells have entered the subretinal space.

PMID- 1020071
TI  - Radiotherapy of malignant melanoma of the choroid.
AB  - Twenty-two patients with choroidal melanomas were treated conservatively using
      radioactive radon rings with a mean follow-up of 43 months. In 14 patients there
      was successful tumor regression. Eight eyes were enucleated because of inadequate
      tumor response. Of the patients whose tumors were apparently destroyed, two have
      subsequently died of metastases and one eye was enucleated due to scleral
      rupture. Of the eight cases unsuccessfully treated, one has subsequently died of
      metastases. Radiation therapy is likely to be effective in patients with tumors 7
      mm in diameter and 2 mm in elevation or less. Tumors larger than 12 mm in
      diameter and 3 mm in elevation do not respond adequately to irradiation.
      Relatively large doses of radiation (at least 8,000 rads to the tumor apex) must
      be used if the tumor is to be effectively obliterated. We believe that radiation
      effectively can destroy small choroidal melanomas.

PMID- 1020072
TI  - Clinical experience with presumed hemangioma of the choroid: radioactive
      phosphorus uptake studies as an aid in differential diagnosis.
AB  - A total of 27 cases of choroidal hemangioma was evaluated with radioactive
      phosphorus uptake studies. In each case the diagnosis of malignant melanoma was
      initially entertained, but the 32P test was unequivocally negative in every
      instance. Follow-up studies in every case have supported the clinical diagnosis.
      In 22 patients, the lesion was treated with photocoagulation, and in every
      treated case the serous macular detachment disappeared. The importance of early
      and correct clinical diagnosis is stressed, since these are salvageable and
      potentially useful seeing eyes.

PMID- 1020073
TI  - Lipofuscin pigment over benign and malignant choroidal tumors.
AB  - This study has shown that lipofuscin pigment may accumulate in RPE cells and
      macrophages over several types of benign and malignant choroidal tumors. The
      color of the pigment, however, varies with the nature and color of the underlying
      lesion. On the surface of deeply pigmented tumors the lipofuscin pigment may
      produce an orange color, whereas over amelanotic lesions it may appear brown or
      reddish-brown. On the surface of vascular tumors, such as choroidal hemangiomas,
      the lipofuscin is almost invisible ophthalmoscopically but may be demonstrated
      with fluorescein angiography. Although the presence of such pigment accumulation
      is suggestive of a malignant melanoma, it is not diagnostic and may occur over
      benign simulating lesions as well.

PMID- 1020074
TI  - A comparison of the sensitivity of carotid compression tonography with
      ophthalmodynamometry in the diagnosis of internal carotid artery occlusive
      disease.
AB  - The cases of 100 consecutive patients with arteriographic evidence of carotid
      occlusive disease were reviewed. All 100 patients had undergone ODMY and CCT
      prior to carotid arteriography. A comparison of the sensitivity of ODM testing
      with CCT testing revealed the ODMY pressure differences were reliable in
      detecting carotid occlusive disease in only 70 of these 100 patients, whereas CCT
      testing detected decreased blood flow on the involved side in 95 of the 100
      patients. The advantages of CCT testing are discussed, comparing certain
      limitations and contraindications often encountered with ODMY testing. The CCT
      test is more sensitive than ODMY testing and is easier to perform. In addition,
      the results of CCT are more objective and provide a permanent record which can be
      analyzed at any time to check for reproducibility. Overall, the CCT test appears
      to be a more suitable screening test than ODMY to study carotid occlusive
      disease.

PMID- 1020075
TI  - Denervation of the inferior oblique: current status and long-term results.

PMID- 1020076
TI  - Sphincterotomy scissors.

PMID- 1020077
TI  - Double simultaneous aspirating-irrigating syringes.

PMID- 1020079
TI  - Indirect fundus camera.

PMID- 1020078
TI  - Indirect ophthalmoscopy lens holder.

PMID- 1020080
TI  - A lens implant holder.

PMID- 1020081
TI  - A micro iris retractor.

PMID- 1020082
TI  - Infusion-aspiration control.

PMID- 1020083
TI  - Lid eversion clamp.

PMID- 1020084
TI  - Lacrimal duct probing light.

PMID- 1020085
TI  - Variable fixation lid clamp (Bethesda-Gavaris clamp).

PMID- 1020086
TI  - The Girard-Storz assistant's microscope: a new accessory for the Zeiss operating
      microscope system.
AB  - A bracket has been designed for the Zeiss 1 and Zeiss 6 operating microscopes,
      enabling the mounting of two accessory microscopes for the surgeon's assistants.
      These accessory microscopes operate independently of the primary microscope and
      in many cases may be preferable to beam-splitter systems which drastically reduce
      illumination to the primary microscope and preclude the use of photographic
      accessories.

PMID- 1020087
TI  - A new phacoliquification cryoprobe.

PMID- 1020088
TI  - An improved method of viewing topical fluorescein.

PMID- 1020089
TI  - A new binocular scotometer.
AB  - A new method of binocular scotometry is described based on an intriguing
      binocular phenomenon and using a new binocular scotometer and a retinoscope with
      its head reversed. Shortcomings in previous attempts have been corrected by
      objectively aligning a "blind" eye with the center of a translucent opalescent
      screen. This was made possible by having the patient rotate the retinoscope to
      induce conjugate eye movements in cases of manifest eye deviation. The examiner
      could then observe the "blind" eye directly through a central opening in the
      screen, by reinforced assistance through dependence on the corneal light reflex
      and, if necessary, by circumferential plotting.

PMID- 1020091
TI  - Closed-circuit television magnification of fluorescein angiography.

PMID- 1020090
TI  - A new machine for irrigation-aspiration.
AB  - This new irrigation-aspiration system (Fig 9) demonstrates application of basic
      physical principles to a particular medical problem, maintaining the integrity of
      the anterior chamber during aspiration of cataractous material. This system is
      readily incorporated into the standard procedure of irrigation-aspiration of soft
      cataractous material at relatively low cost. The surgical procedure and the
      operation of this system with irrigation-aspiration and "prevent-collapse"
      components are under direct control of the physician.

PMID- 1020092
TI  - Fiberoptic conjunctivorhinostomy probe.

PMID- 1020093
TI  - The double-ring support: an instrument to insure safety with scleral buckling
      after cataract extraction.

PMID- 1020094
TI  - Retinal cryoring: a new instrument for retinal surgery.
AB  - The retinal cryoring, a doughnut-shaped cryoprobe, has been developed to allow
      continuous cryocoagulation around retinal holes.

PMID- 1020095
TI  - Treatment of post-cataract bacterial endophthalmitis with periocular and systemic
      antibiotics and corticosteroids.

PMID- 1020096
TI  - Armed Forces Institute of Pathology. American Registry of Pathology.

PMID- 1020097
TI  - Reduction of nasal orbital fractures and simultaneous dacryocystorhinostomy.
AB  - A technique for restoration of structure and function in naso-orbital fractures
      has been described. Three case reports demonstrate a few of the final results.
      The case reports also indicate that many of these fractures require late
      definitive surgery in spite of optimal surgical treatment immediately subsequent
      to injury.

PMID- 1020098
TI  - Traumatic vertebral artery aneurysm.

PMID- 1020099
TI  - Metastatic adenocarcinoma to the larynx: report of a case.

PMID- 1020100
TI  - Cemento-osteoid tumor of the maxillary sinus.

PMID- 1020101
TI  - Meibomian gland carcinoma of the ocular adnexa.

PMID- 1020102
TI  - Hemangiopericytoma of the nasopharynx.

PMID- 1020103
TI  - Liposarcoma of the larynx.

PMID- 1020104
TI  - Carcinoma in thyroglossal duct cysts--a review.

PMID- 1020105
TI  - Malignant ameloblastoma of the maxilla.
AB  - This case illustrates a rare occurrence of an ameloblastoma arising in the
      maxilla and metastasizing to the neck and lungs within a three-year period
      following the initial resection. A discussion of the pathology is presented and
      the necessity for aggressive initial therapy with close follow-up is emphasized.

PMID- 1020106
TI  - Cholesteatoma of the frontal sinus.

PMID- 1020107
TI  - The value of electron microscopy in the diagnosis of fibrosarcoma of the larynx.

PMID- 1020109
TI  - Achieving the educational objectives of a short postgraduate course.

PMID- 1020108
TI  - The case for elective prophylactic neck dissection.

PMID- 1020110
TI  - The risks and limitations of the course as providing competent training.

PMID- 1020111
TI  - The need for a postgraduate review committee for these courses.

PMID- 1020112
TI  - The role that these courses may have in the future regarding credit hours toward
      recertification.

PMID- 1020113
TI  - Cytopathological effects of detergents on Paramecium caudatum.

PMID- 1020114
TI  - [Endodyogeny in Eimeria stiedi merozoites].

PMID- 1020115
TI  - Natural preservation of corpses of Paramecium aurelia in cultures of a suctorian.

PMID- 1020116
TI  - Role of vitamin E in regulating malaria expression.

PMID- 1020117
TI  - Striate muscle dysfunction in iron deficiency.

PMID- 1020118
TI  - The effect of synthetic androgens in hereditary angioneurotic edema: alteration
      of C1 inhibitor and C4 levels.

PMID- 1020119
TI  - Plasma 5alpha androstanediol: an androgen marker of hirsuitism in women.

PMID- 1020120
TI  - Introduction of missing enzymes into the cytoplasm of cultured mammalian cells by
      means of fusion-prone liposomes.
AB  - It is therefore possible to introduce enzyme-laden liposomes into two sites
      within the cytoplasm of cells previously lacking such enzymes. The first site is
      gained after enzyme-laden liposomes are phagocytosed into the lysosomal
      apparatus. Liposomes coated with immunoglobulins engender their own uptake by
      inducing the Fc receptor of phagocytic cells to launch ingestion of the vector as
      if it were an opsonized bacteria or virus against which the host had mounted an
      immune response. As for the second site, described here, involving enzyme
      deficiencies of the free cytosol, these may be corrected when liposomes have
      lysolecithin incorporated as a fusogen. The fusogen induces merger of the
      liposomal membrane with that of the plasma membrane presumably by virtue of the
      capacity of lysolecithin to engender mixed, fusion-prone micelles. Introjection
      of enzymes or other sequestered molecules is accomplished without access of these
      to external solutes, such as calcium. Consequently, uptake of enzyme cannot be
      due to trivial factors such as pinocytosis induced by lysolecithin or to
      phagocytosis per se. These two new techniques of cellular engineering now render
      it possible to introduce either into phagocytic or into non-phagocytic cells,
      enzymes or macromolecules in which these cells are genetically deficient.

PMID- 1020121
TI  - Evidence for reflex coronary artery spasm in patients with ischemic heart
      disease.

PMID- 1020122
TI  - A new look at the metabolism of the arterial wall.

PMID- 1020123
TI  - A reticulo-epithelial system: cutaneous trap for antigens.

PMID- 1020124
TI  - Reduced renal papillary plasma flow in Dahl and Kyoto spontaneous hypertensions.

PMID- 1020126
TI  - Horatius Cocles at the bridge of publication.

PMID- 1020125
TI  - The Association of American Physicians: its first seventy-five years.

PMID- 1020127
TI  - The distinguished lecture: Pyrrolic victories.

PMID- 1020128
TI  - Management of prostatic fistulas.
AB  - Prostatic fistulas communicating with the rectum or perineal skin are unusual
      complications of a prostatic operation, pelvic trauma, prostatic abscess or other
      iatrogenic injury. A third of these fistulas may close spontaneously with proper
      urinary drainage and avoidance of fecal soilage. The many operative procedures
      described for the repair of these fistulas indicate that no ideal method of
      repair can be applied to every case. Operative management should be mandated by
      the size, location and duration of the fistula as well as by the surgeon's
      experience with the various anatomic approaches.

PMID- 1020129
TI  - [Methodology of tonography].

PMID- 1020130
TI  - [Pathologicanatomic changes in the eye in Sturge-Weber disease].

PMID- 1020131
TI  - [Clinical classification of concomitant squint].

PMID- 1020132
TI  - [Clinical and functional outcomes of endonasal and external
      dacryocystorhinostomy].

PMID- 1020133
TI  - [Shape of the eye in children with varying refraction].

PMID- 1020134
TI  - [Comparative morphological study of experimental retinal cryopexy and diathermic
      coagulation].

PMID- 1020135
TI  - [Coagulation of macular ruptures of the retina].

PMID- 1020136
TI  - [New method for the retrograde intra-arterial administration of drugs into the
      ophthalmic artery in treating eye diseases].

PMID- 1020137
TI  - [Effective method of administering ophthalmic drug forms].

PMID- 1020138
TI  - [Drug allergy in ophthalmology].

PMID- 1020139
TI  - [Immunogenetic "mother-child" interrelationships according to ABO antigens in
      strabismus].

PMID- 1020140
TI  - [Experimental echographic characteristics of intraocular fragments].

PMID- 1020141
TI  - [Table for determining the volume of the vitreous body based on echographic
      biometry data].

PMID- 1020142
TI  - [Stereoarteriographic symptoms of meningiomas of the orbit].

PMID- 1020143
TI  - [Semilanceolate knife-probe for operations on the lacrimal points and
      canaliculi].

PMID- 1020144
TI  - [Device for holding the sclera in diascleral interventions].

PMID- 1020145
TI  - [Changes in the fundus oculi in severe craniocerebral injury in different age
      groups].

PMID- 1020146
TI  - [Combined unilateral anomaly of the optic and acoustic nerves].

PMID- 1020147
TI  - [Vibromassage in the ophthalmologist's practice].

PMID- 1020148
TI  - [Ophthalmological complications of ethambutol treatment].

PMID- 1020149
TI  - [Pathogenesis of ciliochoroidal detachment and its effects on the results of
      antiglaucoma operations].

PMID- 1020150
TI  - [Tomographic study of ethmoid labyrinths].

PMID- 1020151
TI  - [Diagnostic value of electroroentgenography in diseases of the nasopharynx, nasal
      cavity and accessory sinuses].

PMID- 1020152
TI  - [Clinical manifestations of chronic adenoiditis not associated with hypertrophy
      of pharyngeal tonsils].

PMID- 1020153
TI  - [Study of the effect of ultrasonics on the lymphoid tissue of the palatine
      tonsils in children].

PMID- 1020154
TI  - [Age-specific and individual characteristics of pneumatization of the pyramid of
      the temporal bone].

PMID- 1020155
TI  - [Basic tasks of Soviet otorhinolaryngology in the light of resolutions of the
      25th Congress of the Communist Party of the Soviet Union].

PMID- 1020156
TI  - [Comparative evaluation of sound conductivity of the skull in young and old
      persons].

PMID- 1020157
TI  - [Possibilities of traveling by air after stapedectomy].

PMID- 1020158
TI  - [Qualitative characteristics of olfactory disorders after stable nose injuries].

PMID- 1020159
TI  - [Functional state of the vestibular analyzer in persons working with the lasers].

PMID- 1020160
TI  - [Vestibular neuronitis].

PMID- 1020161
TI  - [Basic principles of work capacity evaluation of patients with vestibular
      disorders in chronic encephalitis and arachnoiditis].

PMID- 1020162
TI  - [Dynamics of glucocorticoid activity of the adrenal cortex during treatment of
      children with laryngostenosis].

PMID- 1020163
TI  - [Case of sarcomatous arachnoendothelioma of the middle ear].

PMID- 1020164
TI  - [Thrombosis of the internal jugular vein with extensive necrosis of the soft
      tissues of the neck as a complication of mastoiditis].

PMID- 1020165
TI  - [Cases of combined lesion of the auditory and olfactory analyzers].

PMID- 1020166
TI  - [Infection as a complication of puncture of the maxillary sinus].

PMID- 1020167
TI  - [Case of multiple foreign bodies in the respiratory tract].

PMID- 1020168
TI  - [Foreign body of the soft tissues of the upper lip and of the floor of the nasal
      cavity].

PMID- 1020169
TI  - [2 cases of brain tumors with the symptoms of intracranial complications of
      purulent hemisinusitis and purulent epitympanitis].

PMID- 1020171
TI  - [Treatment of furunculosis of the external auditory meatus].

PMID- 1020170
TI  - [Orbital abscess and brain abscess as complications of purulent frontitis and
      ethmoiditis].

PMID- 1020172
TI  - [Method of tracheobronchial spraying of drugs in aerosols].

PMID- 1020173
TI  - [Pathogenesis and treatment of bronchial asthma].

PMID- 1020174
TI  - [Diagnosis of chronic venous diseases of the legs under polyclinical conditions].

PMID- 1020175
TI  - [Errors in diagnosis and treatment of acute apendicitis].

PMID- 1020176
TI  - [Sepsis in a surgeon caused by infection during surgery].

PMID- 1020177
TI  - [Use of mathematical methods of evaluation of the severity of patients'
      condition].

PMID- 1020178
TI  - [2 cases of treatment of pancreatic cyst].

PMID- 1020179
TI  - [Acute respiratory insufficiency caused by retrosternal goiter].

PMID- 1020180
TI  - [Left-sided appendicitis].

PMID- 1020181
TI  - [Echinococcosis of the spleen].

PMID- 1020182
TI  - [Cyst of the small pelvis in a man].

PMID- 1020183
TI  - [Preoperative correction of volemic disorders in thyrotoxicosis].
AB  - The investigations conducted by the authors enabled them to pinpoint further the
      complex of symptoms determining a phase character of volemic disturbances in
      thyrotoxicosis. The phases somewhat reveal the volemic substrate of
      thyrotoxicosis, allowing an aimed management of some stages of the preoperative
      preparation. The latter is conventionally divided according to Sh. Milk into
      three periods: initial, intermediate and final. The main aim of the preoperative
      correction is to normalize hydration correlations, that is likely to be gained by
      excreting excessive sodium and replenishment of potassium deficit.

PMID- 1020184
TI  - [Diagnostic possibilities of peritoneography in surgical practice].
AB  - Peritoneography with diagnostic purposes was employed in 53 patients. 24-45%
      water soluble iodine-containing contrast substances were infused
      intraabdominally. In 48 patients pathological processes in the abdominal cavity
      were revealed. No pathology was found in 5 patients.

PMID- 1020185
TI  - [Gastrogenic tetany].

PMID- 1020186
TI  - [Importance of the method of timely external drainage of the pancreatic duct in
      transduodenal papillectomy and pancreatoduodenal resection].
AB  - With the aim of prophylaxis against postoperative pancreatitis in transduodenal
      papillectomy and pancreatoduodenal resection the authors have elaborated the
      technic of a provisional external drainage of Wirsung's duct by means of a
      controlled transnasal drainage. Ten operations were performed using this technic.
      There were two deaths. The recommended technic provides a free outflow of the
      pancreatic juice from the pancreas outwardly during several days after the
      operation.

PMID- 1020187
TI  - [Pericardiectomy for constrictive pericarditis in middle-aged patients].

PMID- 1020188
TI  - [Disorders of motor function of the stomach in acute appendicitis].
AB  - The authors have studied the motoric activity of the stomach in 40 patients with
      acute appendicitis and in 15 patients with other lesions. In appendicitis the
      strength and depth of gastric contractions were found to be mostly labile, while
      the number of waves of gastric contractions was relatively constant.

PMID- 1020189
TI  - [Results of treatment of patients with appendiceal infiltrate].
AB  - In the clinic a differential therapeutic tactics is employed in appendicular
      infiltration (570 patients). If pain attacks following appendicular infiltration
      are absent then only a detailed examination of a patient is able to give
      indications to a planned appendectomy.

PMID- 1020190
TI  - [Thiamine and pyruvic acid content in the urine of patients with ununited
      fractures and pseudarthroses].
AB  - The authors report the results of studies on the thiamine and pyruvic acid
      content in the urine of 170 individuals (34 healthy persons and 136 patients with
      no union of fractures and pseudarthrosis). In patients with nonunited fractures
      and pseudarthrosis a deficiency of vitamin B1 is observed.

PMID- 1020191
TI  - [Thromboses in children].

PMID- 1020192
TI  - [Clinico-roentgenological characteristics of acute lung abscess].
AB  - Based on an analysis of the clinico-roentgenological picture of the disease in 48
      patients with acute lung suppuration, the authors have detected some
      peculiarities in clinical manifestations of the disease, and also characteristic
      features of the roentgenological semiotics, which enabled them to define the
      pathological process as "a primary" acute abscess of the lung.

PMID- 1020193
TI  - [Use of dimexide in the treatment of acute hematogenic osteomyelitis in
      children].
AB  - Under observation were 132 children with acute hematogenous osteomyelitis. The
      complex treatment of an acute stage of hematogenic osteomyelitis included also
      the local use of 33% dimexide (DMSO) solution together with antibiotics. The
      observations indicated a high efficacy of the suggested therapeutic method.

PMID- 1020194
TI  - [Diagnosis and treatment of pancreatic necrosis].

PMID- 1020195
TI  - [Operations for hernia].

PMID- 1020196
TI  - [Osteosynthesis of the femur neck with the aid of 2-flange nail].

PMID- 1020197
TI  - [Clinical evaluation of the x-ray data in kidney diseases].

PMID- 1020198
TI  - [Is excretory urography a test of the functional capacity of the kidneys?].

PMID- 1020199
TI  - [State of the kidneys not detectable during intravenous urography].

PMID- 1020200
TI  - [Angiographic study in hydronephrosis].

PMID- 1020201
TI  - [X-ray diagnosis of renal artery aneurysms].

PMID- 1020202
TI  - [Aneurysms of the renal arteries].

PMID- 1020203
TI  - [X-ray diagnostic characteristics of tuberculosis of the kidneys].

PMID- 1020204
TI  - [X-ray and radioisotopic studies of the kidneys in obstetrics and gynecology].

PMID- 1020205
TI  - [Emergency x-ray study of the kidneys and bladder in combined injury].

PMID- 1020206
TI  - [Use of x-ray and radioisotopic methods of study in the diagnosis of kidney
      lesions and their sequelae].

PMID- 1020207
TI  - [Single-stage complex x-ray study in bladder tumors].

PMID- 1020208
TI  - [X-ray data in schistosomiasis of the urinary tracts].

PMID- 1020209
TI  - [Excretory urography in pediatric uronephrology].

PMID- 1020210
TI  - [Current status of x-ray diagnosis in urology[].

PMID- 1020211
TI  - [X-ray and radioisotopic diagnosis in developmental defects of the kidneys in
      children].

PMID- 1020212
TI  - [Ileocavography in tumors of the retroperitoneal space in children].

PMID- 1020213
TI  - [What the physician should know in equipping an angiography office].

PMID- 1020214
TI  - [Diagnosis of pulmonary aspergillomas].

PMID- 1020215
TI  - X-ray diagnosis of acute pneumonia in patients with a generalized meningococcal
      infection.

PMID- 1020216
TI  - [Displacements of the pulmonary vessels in volumetric reduction of the individual
      lobes].

PMID- 1020217
TI  - [Initial x-ray manifestations of the "shock lung" syndrome].

PMID- 1020218
TI  - [Bronchozonography in pulmonary tuberculosis].

PMID- 1020219
TI  - [Rentgenopneumopolygraphic differential diagnosis of disorders of bronchial
      patency in cancer and inflammatory diseases of the lungs].

PMID- 1020220
TI  - [Bronchial arteriography in the differential diagnosis of chronic pneumonia and
      lung cancer].

PMID- 1020221
TI  - [Importance of pneumomediastinotomography in the overall study of the mediastinum
      in cancer and other diseases of the lungs].

PMID- 1020222
TI  - [Experience in using transthoracic needle biopsy under x-ray control].

PMID- 1020223
TI  - [Rare form of metastatic lesion of the pleura].

PMID- 1020224
TI  - Importance of contrast laryngography in the diagnosis of diseases of the larynx.

PMID- 1020225
TI  - [Terminology in tomography].

PMID- 1020226
TI  - [Device for the preparation of the contrast suspension].

PMID- 1020227
TI  - [Increased protection of the RUD-145-250-1 (RUM-10) apparatus].

PMID- 1020228
TI  - [Sarcoidosis of the respiratory organs in the x-ray image].

PMID- 1020229
TI  - [X-ray videometric plane table].

PMID- 1020230
TI  - [Some characteristics of pulmonary sarcoidosis].

PMID- 1020231
TI  - [Methodology of assessing medical supplies].

PMID- 1020232
TI  - [Participation of the military-medical service in the psychological preparation
      of the troops].

PMID- 1020234
TI  - [Expediency of an open sorting area].

PMID- 1020233
TI  - [Experience with the operation of a dictaphone-typing center in a garrison
      hospital].

PMID- 1020235
TI  - [Lumbar sympathectomy in the treatment of obliterating atherosclerosis of the
      lower extremities].

PMID- 1020236
TI  - [Treatment of acute thrombophlebitis and phlebothrombosis of the lower
      extremities].

PMID- 1020237
TI  - [Treatment of patients with fractures of the femur associated with a deep burn].

PMID- 1020238
TI  - [Clinico-histochemical criteria for the diagnosis and effectiveness of treatment
      of early forms of ulcer disease].

PMID- 1020239
TI  - [Clinical picture and treatment of patients with lumbosacral radiculitis].

PMID- 1020240
TI  - [Current principles and methods of treating meningococcal infections].

PMID- 1020241
TI  - [Endocrine system in hypodynamia and readaptation].

PMID- 1020242
TI  - [Changes in the hemodynamics of persons working with nitric acid].

PMID- 1020243
TI  - [External respiratory function among the flight staff].

PMID- 1020244
TI  - [Suppurative diseases of the fingers and hands of sailors].

PMID- 1020245
TI  - [Role and value of blood transfusion while rendering emergency medical services].

PMID- 1020246
TI  - [Neurosurgical treatment of discogenic lumboscaral radiculitis].

PMID- 1020247
TI  - [Experience in organizing dietetic nutrition].

PMID- 1020248
TI  - [Increasing the effectiveness of utilization of new medical technology].

PMID- 1020249
TI  - Survival rate in lung cancer.
AB  - The authors followed the survival rate in 927 patients with lung cancer treated
      in the oncological dispensary of the Plovdiv City during 1965--1972. 41.3% of the
      patients were in stage 1--11, 19.9%--in stage III, 38.8%--in stage iv. Of all the
      patients 8.2% were operated upon, in 14.7%--radiotherapy was employed, 9.9% of
      the patients were treated pharmacologically, 67.5% of cases were not treated at
      all. As a result of all kinds of treatment 21.4% of the patients survived for one
      year, and 1.1%--for 5 years. It is concluded that the search for new methods of
      the treatment and early diagnosis of lung cancer is quite essential.

PMID- 1020250
TI  - [Mass screening in the diagnosis of precancerous diseases of the stomach].
AB  - The authors emphasize the importance of diagnosticating and systematic
      observation of cancer preneoplasms for earlier detection of stomach cancer. For
      this purpose a clinico-laboratory test for thiocompounds in the urine has been
      used. The former has been found to be convenient for mass screening because of
      its prompt performance. Nearly 3.5% of 10000 healthy persons under examination
      have been screened by means of the mentioned test. The effectiveness of the test
      was checked up through an x-ray examination of the stomach of the screened
      persons, i.e. of those who have shown the positive result. Cancer preneoplasms
      have been detected in 32.5% of the x-ray screened persons. It is concluded that
      the used mass screening test, followed by an x-ray examination of those patients
      who showed a positive result for thiocompounds in the urine, could be used as a
      pattern for the detection of pretumor lesions.

PMID- 1020251
TI  - [Indicators of nonspecific immunity in cirrhosis and primary cancer of the
      liver].
AB  - The study of some factors of nonspecific immunity in 85 patients with cirrhosis
      and in 9 patients with primary cancer of the liver revealed a decrease of all
      factors of nonspecific immunity under consideration, while in primary cancer of
      the liver--selective and more sharp fall of properdin level. The complement, as
      compared with the control, was not changed, whereas lysozyme was statistically
      reliably higher than in healthy persons.

PMID- 1020252
TI  - [Endoscopic diagnosis of postoperative stomach cancer].
AB  - The authors examined endoscopically the esophagus and stomach in 309 patients,
      previously operated upon for gastric cancer (258), ulcer of the stomach or
      duodenum (36) and benign gastric tumors (15). They estimated the value of this
      method for establishing diagnosis of the operated stomach cancer and also the
      importance of histological and cytological methods in the complex diagnosis of
      this pathology. Moreover, roentgeno-endoscopic correlations were made. Cancer of
      the operated stomach was detected in 59 patients, it was suspected in 8, other
      lesions were found in 194. no changes in the operated stomach were found in 48.
      It is stated that endoscopy is more advantageous than roentgenological
      examination in establishing the diagnosis of tumor pathology of the operated
      stomach. Histological and cytological findings are of considerable value in
      making the correct diagnosis. These methods are mostly informative in an
      exophytic form of the tumor growth.

PMID- 1020253
TI  - [Cellular immunity in patients with melanoma].
AB  - The main part of tumor-associated antigens of malignant melanoma in both USSR and
      USA preparations is similar. Both samples have an antigen of glycolipoprotein
      nature. This antigen induces a delay of hypersensitivity in patients with
      malignant melanoma. These data suggest that antigens, used for the study of cell
      mediated immunity in patients with malignant melanoma, can be used for an
      estimation of the immunological status. Both antigens are closely similar in
      their main characteristics and, therefore, further comparison of the results to
      be obtained seems to be possible in both countries.

PMID- 1020254
TI  - [Postoperative pneumonia in oncological patients].
AB  - The authors have analysed the incidence of postoperative pneumonias in patients
      with malignant tumors of different localization, who were operated in the N. N.
      Petrov Research Institute of Oncology of the USSR Ministry of Health during the
      period of 1969--1973.

PMID- 1020255
TI  - [Reorganization of oncological service in the Czechoslovak Socialist Republic and
      the long-term oncological program].
AB  - Some statistical data on the malignant tumors morbidity and mortality among the
      population of CSSR are reported. A description of the reogranization of
      oncological aid in CSSR is given, as well as a brief description of long-term
      program on oncology till 1990. It is hoped that the scientists of CMEA member
      states will successfully solve the tasks of the complex problem "Malignant
      neoplasms".

PMID- 1020256
TI  - [Reaction of inhibition of macrophage electrophoretic mobility in differential
      diagnosis of carcinomas].
AB  - The reactivity of the lymphocytes from 40 carcinoma patients and 19 patients
      without detectable malignancies was tested by means of the macrophage
      electrophoresis-mobility (MEM) test exposing lymphocytes from one individual to a
      large spectrum of antigenic preparations. Besides the encephalitogenic protein
      (EP) and the carcino-embryonic antigen (CEA) hypertonic KCl-extracts from human
      cancer and normal tissues were used as antigens to be tested. When performed in
      such a complex manner, the MEM-test resulted in characteristic reaction patterns
      allowing one not only to discriminate between cancer and noncancer, but also to
      draw a conclusion in which organ a carcinoma has arisen. The characteristic
      "immunological tumor profiles", thus obtained, are obviously due to the existance
      of common antigens in carcinomas of the same tissue origin. The CEA seems to be
      another antigen of high diagnostic value in that system, since the lymphocyte
      response to CEA was restricted to patients with tumors of the colon, rectum and
      stomach. The results show for the first time that lymphocytes of the tumor
      patients mentioned are able to react to CEA. The human lymphocyte response to CEA
      seems to be far more cancer- and (or embryo-specific than the reactions obtained
      with xenogenic hyperimmune sera) which areused for the detection of CEA in human
      sera or plasma samples. The "immunological tumor profile" opens a new step of
      quality among the attempts to develop immunological tumor tests.

PMID- 1020257
TI  - [Determination of benzopyrene in the seeds of plants before and after their
      germination].
AB  - The possibility of BP synthesis in plants was studied. Seeds of pea, lupine, rye,
      oats, garden-cress were investigated in hydroponic systems with substrates
      containing carbon and without it. The results indicated that the quantity of BP
      in the seeds increased in the course of germination in solutions with carbon from
      1 to 7 mug/Kg of dry weight. No increase of BP was observed after germination in
      media without carbon.

PMID- 1020258
TI  - [Papillomas of the urinary bladder induced by N-nitroso-N-methylurea in rats].
AB  - N-nitroso-N-methylurea (a total dosage--6 mg per animal), administered by a
      catheter in the urinary bladder cavity in female rats, following 9--56 weeks
      induced in 16 of 23 rats tumors of the vesical mucous membrane (mostly
      transitional cell papillomas).

PMID- 1020259
TI  - [Angiography of metastases of squamous-cell carcinoma into the cervical lymph
      nodes].

PMID- 1020260
TI  - [ABO blood-group system in patients with pancreatic cancer].

PMID- 1020261
TI  - [Antineoplastic effect of cis-platinum diamminodichloride (II)].

PMID- 1020262
TI  - [Mitotic activity of the cells of intestinal tumors and bone-marrow under the
      effect of 6-mercaptopurine during the usual and low-sodium diet].

PMID- 1020263
TI  - [Relationship between duration of the latent period after induction of mammary
      neoplasms, season of the year and thyrotropic function of the pituitary gland].

PMID- 1020264
TI  - [Outcome of focal pulmonary tuberculosis in different states of the bronchi].

PMID- 1020265
TI  - [Renal function under the effect of ethambutol treatment of patients with
      destructive pulmonary tuberculosis].

PMID- 1020266
TI  - [Carcinoid of the bronchi complicated by subarachnoid hemorrhage].

PMID- 1020267
TI  - [Effect of local hypothermia on the muscle tonus in spastic paresis].

PMID- 1020268
TI  - [Oxygen tension in tissue and intensity of its utilization in patients with
      chronic inflammatory biliary tract diseases].

PMID- 1020269
TI  - [Determination of blood fibrinogen (fibrin) degradation products by reaction to
      hemagglutination delay of sensitized erythrocytes].

PMID- 1020270
TI  - [Case of primary acute generalized aspergillosis].

PMID- 1020271
TI  - [Biological effect of oil-soluble salts of cyclohexylamine - an inhibitor of
      atmospheric corrosion of metals].

PMID- 1020272
TI  - [Complex research of the cardiovascular system in patients with pneumoconiosis].

PMID- 1020273
TI  - [Clinical aspects and treatment of severe hydrogen sulfide poisoning].

PMID- 1020274
TI  - [Microintoxication in the polyvinyl chloride film industry].

PMID- 1020275
TI  - [Problems of modern influenza epidemiology according to the Ukrainian SSR data].

PMID- 1020276
TI  - [Clinical and epidemiological characteristics of malaria in the City Kiev in 1967
      1974].

PMID- 1020277
TI  - [Experience with prophylactic medical examination of patients with history of
      antigen-positive viral hepatitis B].

PMID- 1020278
TI  - [Evaluation of medical documentation from the legal aspect].

PMID- 1020279
TI  - [Socio-economic aspects of toxoplasmosis].

PMID- 1020280
TI  - [Immunodepressive treatment of chronic liver diseases].

PMID- 1020281
TI  - [Urological morbidity of the population of Nikolaev region].

PMID- 1020282
TI  - [Analysis of causes of delayed diagnosis of stomach cancer].

PMID- 1020283
TI  - [Study of blood serum amino acids in patients following gastric surgery].

PMID- 1020284
TI  - [Conservative and surgical treatment of hiatal hernias].

PMID- 1020285
TI  - [Contents of ascorbic acid and cholinesterase activity of the blood in patients
      with gastroduodenitis].

PMID- 1020286
TI  - [Study of gastric secretion by means of broth prepared from meat cubes].

PMID- 1020287
TI  - [Effect of Eleutherococcus extract on some functions of the digestive organs].

PMID- 1020288
TI  - [Correlation of plasma electrolytes and form elements of the blood in patients
      with chronic enterocolitis].

PMID- 1020289
TI  - [Diagnostic value of calcium chloride test in Zollinger-Ellison syndrome].

PMID- 1020290
TI  - [Therapeutic use of secretin].

PMID- 1020291
TI  - [Renal changes in urolithiasis according to the data of electron microscopy].

PMID- 1020292
TI  - [Effect of vitamin B 15 on urinary excretion of catecholamines in older people].

PMID- 1020293
TI  - [Experience with treatment of insulin lipodystrophy].

PMID- 1020294
TI  - [Vitamin C balance in patients with diabetes mellitus].

PMID- 1020295
TI  - [Current problems in medical neurogenetics].

PMID- 1020296
TI  - [Effect of heparin electrophoresis on myocardial function in patients with
      arteriosclerosis].

PMID- 1020297
TI  - [Electrolytes and electrical activity of the heart in patients with ischemic
      disease].

PMID- 1020298
TI  - [Treatment of patients with cerebral forms of hypertensive disease by combination
      of decamevit with unithiol in conditions of biotron].

PMID- 1020299
TI  - [Significance of separate renal function tests for differential diagnosis of
      hypertension].

PMID- 1020300
TI  - [Pathohistology of allergic vasculitis of the skin].

PMID- 1020301
TI  - Frequency of vasculitis and their diagnosis in great collagenoses.

PMID- 1020302
TI  - [Case of paroxysmal cardiac arrhythmia in vibration disease].

PMID- 1020303
TI  - [Changes of terminal part of ventricular complex of the electrocardiogram in
      patients with pneumonia].

PMID- 1020304
TI  - [Conditioning function of the apparatus of external respiration in pneumonia of
      viral etiology].

PMID- 1020305
TI  - [Drug aerosols in complex treatment of broncho-pulmonary diseases].

PMID- 1020306
TI  - [Pathomorphosis of lung cancer following preoperative intensive split radiation].

PMID- 1020307
TI  - [Case of lung agenesis].

PMID- 1020308
TI  - Food and nutrition policies in a changing environment.

PMID- 1020309
TI  - An evaluation of "informed consent" with volunteer prisoner subjects.
AB  - "Informed consent" sets a goal for investigators experimenting with human
      subjects, but little is known about how to achieve or evaluate it in an
      experiment. In a 3-year, double-blind study with incarcerated men, we attempted
      to provide a "free and informed consent" and evaluated our efforts with an
      unannounced questionnaire administered to subjects after they completed the
      experiment. At that time, approximately two-thirds had sufficient information for
      an informed consent, but only one-third was well informed about all key aspects
      of the experiment and one-third was insufficiently informed to give an informed
      consent. We found that institution- or study-based coercion was minimal in our
      experiment. From our evaluation of the questionnaire and experience at the study
      institution, we conclude that an experiment with human subjects should be
      designed to include an ongoing evaluation of informed consent, and active
      attempts should be made to avoid or minimize coercive inducements. Experiments
      with significant risk, which require a long duration and/or large sample size
      relative to the institution's population, should probably not be performed on
      prisoner subjects. The experimenter should be independent of the penal
      institution's power structure. Presenting and explaining a consent form to
      volunteers on one occasion is probably an in adequate procedure for obtaining and
      maintaining an informed consent.

PMID- 1020310
TI  - The ethical responsibility of the physicians: a judeo-christian perspective.

PMID- 1020311
TI  - On taking vows in two priesthoods, scientific and christian.

PMID- 1020312
TI  - Coronary artery disease with single coronary artery.
AB  - The authors have reviewed the literature in search of the coexistence of single
      coronary artery with significant coronary artery disease. Two cases of single
      right coronary artery are described. In both, the anomalies were unsuspected and
      diagnosed roentgenographically in life. Both patients had angina pectoris,
      positive graded-exercise stress tests, and hemodynamically significant
      obstruction or occlusion to the coronary arteries. In neither case was the
      stenosis proximal or amenable to bypass surgery.

PMID- 1020313
TI  - [Causes of ileus adhesions].

PMID- 1020314
TI  - [Intrasternal infusions].

PMID- 1020315
TI  - [A new instrument for rectoscopy].

PMID- 1020316
TI  - [Radiologic diagnosis of soft-tissue tumors of the extremities].

PMID- 1020317
TI  - [Mechanical infusion of adipiodon--additional comments on the work of Wolff, E.,
      and H. Meinel, "Infusion cholecystangiography instead of conventional injection
      methods--radiography of the bile ducts with few complications" (Z. arztl Fortbild
      70 (1976), 481-2)].

PMID- 1020318
TI  - [Contents of the "family medicine chest" of old-age pensioners].

PMID- 1020319
TI  - [Diagnosis and therapy of psychovegetative syndrome of the locomotor system].

PMID- 1020320
TI  - [Life expectancy in humans].

PMID- 1020321
TI  - [Feasibility of an efficiency- and quality-rating in a public health
      establishment].

PMID- 1020322
TI  - [Office-hours activity of medical specialists in general medicine. Concept and
      results of an empirical analysis. 2].

PMID- 1020323
TI  - [The problem of focus in dermatoses].

PMID- 1020324
TI  - [Socialist federations and health protection].

PMID- 1020325
TI  - [Antibacterial therapy of the chronic bronchitic syndrome with special reference
      to the combination trimethoprim/sulfamethoxazole].

PMID- 1020326
TI  - [Osteotomy without fragment fixation in the surgical treatment of coxarthrosis].

PMID- 1020327
TI  - [Immunoprophylaxis of gas gangrene].

PMID- 1020328
TI  - [Exogenic psychoses in brain tumors].

PMID- 1020329
TI  - [Methodological and diagnostic problems in juvenile blood pressure
      determinations].

PMID- 1020330
TI  - [Human infections with herpes simplex virus].

PMID- 1020331
TI  - [Possibilities and limitations in the pulse frequency measurement by the patient
      during rehabilitation after myocardial infarct].

PMID- 1020332
TI  - [The length of hospitalization of urologic patients in Berlin in 1969].

PMID- 1020333
TI  - [Organization of increased efficiency on the hospital ward].

PMID- 1020334
TI  - [Long term studies on rheumatic patients].

PMID- 1020335
TI  - [Mechanics of breathing and contractility of myocardium of right ventricle in
      chronic bronchial obstruction (author's transl)].
AB  - The Reaction of the right ventricle on pulmonary hypertension in chronic
      bronchial obstruction is to be described. Limitation of myocardial contraction
      capacity may be measured by - the index of contractility, - the tension-time
      index of the right ventricle and - the tendency of systolic stain-pressure to
      reach diastolic pulmonary arterial pressure in time of maximal pressure-elevation
      velocity.

PMID- 1020336
TI  - [Hemodynamic analysis of pulmonary circulation by microcatheter technique in
      healthy persons and in patients with pulmonary silicosis (author's transl)].
AB  - A comparison of hemodynamic analysis of pulmonary circulation in 18 healthy men
      (PM less than 20 Torr) and 19 patients with pulmonary silicosis (PM larger than
      or equal to 20 Torr) at rest and under work load gave following results: In most
      healthy persons pulmonary pressure rose under load while resistance of pulmonary
      circulation decreased significantly. In patients with silicosis pulmonary
      pressure being elevated at rest reached pathological values under load while
      resistance of circulation decreased less. There was no difference in cardiac time
      volume between both groups. The authors found a linear correlation between
      cardiac time-volume and oxygen uptake related to body surface. They derived a
      formula of approximating cardiac time-volume by oxygen uptake and body surface.

PMID- 1020337
TI  - [Analysis of pulmonary mechanics in patients with silicosis (author's transl)].
AB  - Parameters of pulmonary mechanics were measured at rest and during physical
      effort in patients with silicosis and normal subjects. Between normal subjects
      and patients with silicosis of stage I a significant difference could not be
      found. However, a decrease of dynamic compliance and an increase of elastic work
      of breathing were found in patients with silicosis III during exercise. The PT/VT
      quotient is already high at rest. These results are not in agreement with the
      subjective symptom "dyspnea". The feeling of dyspnea appears when the PT/VT
      quotient is enhanced signifcantly during exercise in comparison with the value at
      rest. Therefore, only the PT/VT-quotient is a suitable parameter indicating
      dyspnea.

PMID- 1020338
TI  - [Bodyplethysmographic analysis in patients with silicosis (author's transl)].
AB  - Pulmonary airway resistance was measured in patients with silicosis and in normal
      subjects using a volume-constant bodyplethysmograph. Values of total resistance
      RT were compared with spirometric ventilation parameters, oxygen tension during
      steady-state-exercise and arterial blood pressure. The analysis shows a
      significant relationship between status of silicosis and the degree of
      resistance. Resistance values were found enhanced also in comparison with a
      decrease of vital capacity and FEV1 and with an increase of residual volume and
      arterial blood pressure.

PMID- 1020339
TI  - [Computer analysis of mechanics of breathing by semi-on-line technique (author's
      transl)].
AB  - A program for the analysis of lung mechanics based on esophageal technique and
      running on mini-computer Cellatron 8205 is described. There are two varieties of
      analog-digital-conversion of primary flow- and pressure-signals from magnet tape
      storage to punch tape input channel using transposition of frequency either with
      sequential or alternating data collection oriented on respiratory half-cycles and
      unlimited in view of function test time. The program gives a complete status of
      lung mechanical parameters per respiratory half-cycle and total-cycle, that is
      pulmonary compliance, elastance, maximal resistance, minimal resistance, peak
      flow resistance, initial and terminal standard flow resistance, total, static and
      dynamic work of breathing, power of breathing. Output is provided both in writing
      and punching results to establish the connection with sequential high-level
      programs of lung mechanics and statistical data processing.

PMID- 1020340
TI  - [Generation and determination of pulmonary distribution disturbances (author's
      transl)].
AB  - Pulmonary distribution disturbances could be generated in patients with bronchial
      hyperreactivity by inhalation of a Falicain aerosol
      (Propoxipiperocainhydrochlorid); The inhomogeneities of ventilation and mechanics
      of breathing were determined by means of several simple and complex methods.
      Comparison between these methods of analysis of distribution shows that small
      alterations of inhomogeneity can be indicated also by simple screening tests. The
      results confirm the significant relationship between ventilation disturbance and
      pulmonary inhomogeneity. Distribution disturbance enhances both the obstructive
      and the restrictive component of a ventilation disturbance. These two components
      cannot be separated exactly by means of the parameters of ventilation and
      mechanics of breathing because of the influence of inhomogeneity. The generated
      disturbances of distribution and ventilation became regular after inhalation of
      an Alupent aerosol.

PMID- 1020341
TI  - [Ventilation, gas-exchange and pulmonary arterial pressure during aerosol
      inhalation of sympathicomimetics (author's transl)].
AB  - The effect of inhalation of Novodrin (beta-receptor-stimulus), Phenylephrine
      (alpha-receptor-stimulus) and of a mixture of both was tested in patients with
      chronic nonspecific respiratory syndrome. There was no significant difference of
      pulmonary arterial mean-pressure. Forced expiratory volume and vital capacity
      rose both after inhalation of Novdrin and after inhalation of the mixture.
      Nevertheless inhalation of the mixture can not be recommended because of a
      significant decrease of arterial oxygen-tension.

PMID- 1020342
TI  - [Blood gas-analysis and heart catheterisation in newborns with extreme low oxygen
      content of arterial blood because of congenital heart failure (complete
      transposition of great vessels) (author's transl)].
AB  - Importance of atrial septostomia in newborns with complete transposition of the
      great heart vessels was to be proved in 75 children, 27 of them with an atrial
      shunt and 48 without additional shunt. Arterial oxygen-tension while breathing
      roomair rose from 19 Torr without shunt to 29 Torr after septostomia.
      Corresponding values while breathing oxygen are 23 Torr before and 40 Torr after
      septostomia. In 14 children 2-5 years after septostomia control-values of oxygen
      tension were 42 Torr in aorta (ventr. dext.), 34 Torr in v. cava, 67 Torr in a.
      pulm. (ventr. sin.) and 104 Torr in v. pulm. Differences of oxygen-content were
      2,97 vol.% between aorta and v. cava, 2.83 vol.% between v. pulm. and a. pulm.,
      7.46 vol.% between v. pulm. and aorta and 10.34 vol.% between v. pulm. and v.
      cava.

PMID- 1020343
TI  - [The efficacy of spironolacton in cardiopulmonary insufficiency (author's
      transl)].
AB  - In 17 patients with cardiopulmonary insufficiency the authors found a significant
      positive inotropic heart effect and a moderate improvement of ventilation after
      one injection of 400 mg Spirolacton. 2. The positive inotropic effect is
      experimentally confirmed in 8 dwarf pigs. 3. In 13 patients with severe cardiac
      and cardiopulmonary insufficiency a tendency to normalization of arterial blood
      gases, of actual bicarbonate and of vital capacity was found. There may be an
      indirect effect on the respiratory center by alteration of acid-base-status and
      by diuresis causing diminuation of pulmonary compliance. Spironolacton seems to
      be a valuable therpeutical completion in cardiac and cardiopulmonary insufficency
      in its intravenous quick application and its oral time application.

PMID- 1020344
TI  - [Alternate-day prednisolone therapy in lung sarcoidosis (author's transl)].
AB  - Thirty patients with a biopsy-proven sarcoidosis of the lung (state I = 5, state
      II = 24, state III = 1 patient(s) were subjected to a primary alternate-day
      prednisolone therapy. After a treatment of 6 months all signs of sarcoidosis of
      state I and about two thirds of state II disappeared completely. In one third of
      the cases of state II (mainly broad focal and extensively infiltrative types of
      sarcoidosis as well as relapses the inflammatory changes in patients could be
      suppressed, but moderate fibrous residues remained. One case of progressive
      sarcoidosis of state III proved to be nearly resistant to therapy. Substantial
      side effects were not observed. Since the alternate-day prednisolone therapy is
      highly effective and nearly without any risk it is recommended to all patients
      with sarcoidosi needing therapy.

PMID- 1020345
TI  - [Results of catheter biopsy and catheter aspiration in various lung diseases
      (author's transl)].
AB  - Results of 415 catheter biopsies and catheter aspirations in patients with
      various lung diseases are reported. Among 263 patients with suspected carcinoma
      of the lung, in 79% neoplastic cells could be obtained histologically from
      catheter biopsy specimens. Among 52 patients with suspected pulmonary
      tuberculosis but without positive sputum, tubercle bacilli were found in 23% by
      aspiration biopsy. The bacteriological examination of bronchial secretion in
      various lung diseases showed a prevailing growth by diplococcus pneumoniae, and
      more sterile conditions in the peripheral bronchial airways of 56 patients.
      Catheter biopsy proves to be a valuable diagnostic method for the detection of
      peripheral bronchial carcinomas and the catheter aspiration for the
      bacteriological examination in specific and non-specific lung diseases.

PMID- 1020346
TI  - [Pulmonary changes in a female patient with Pringle's syndrome (author's
      transl)].
AB  - The Pringle's Syndrome (Synon. adenoma sebaceum) is a very variable illness,
      based on a congenital neuroectodermal genetic defect. The hereditary transmission
      is dominant and it can be very various. The pulmonary involvement in Pringle's
      Syndrome is very rare. A case of a 25 year old female patient is demonstrated.
      She suffered on spontaneous pneumothoraces in both sides and had many typical
      alterations in other organs. Further examinations revealed disseminated small
      cystic alterations in the lung. Histologically these changes are based on a
      congenital defect of bronchioli. The patient's cardiopulmonal efficiency is
      assessed regarding to its prognosis. Finally the necessity of genetic care for
      patients with Pringle's Syndrome is pointed out.

PMID- 1020347
TI  - [Mediastinoscopy and scar-keloid's in boeck's sarcoid (author's transl)].
AB  - The paper represents the results of the mediastinoscopy in 135 cases of Boeck's
      sarcoid. The frequent formation of keloid's in the scar of the mediastinotomy is
      emphasized. The histological examinations of the scar keloid's after
      mediastinoscopy are compared with histological examinations of scars after
      resections of the thyroid glands. The possible reasons of the differences are
      discussed.

PMID- 1020348
TI  - [Pericardial injuries due to mediastinoscopy (the anatomy of the recussus
      aorticus pericardii) (author's transl)].
AB  - According to results obtained on the topographical studies of the anatomy of the
      recessus aorticus pericardii the authors stress the possibility of the
      vulnerability of the pericard due to mediastinoscopy, since its retroaortal fold
      reaches up to the truncus brachio-cephalicus and its broad-assertion up to the a.
      pulmonalis.

PMID- 1020349
TI  - [The bronchusplasty with lung-resections -- a conservative method of operation in
      tumor surgery (author's transl)].
AB  - Report regarding 32 patients with bronchusplasty in lung resections on account of
      semimalignant and malignant tumors. Operative indications, -technique,
      postoperative complications and results up to now are discussed.

PMID- 1020350
TI  - [Pulmonary artery pressure in the pathophysiology of lung-resections therapy.
      Part I: standard values, surgical lung diseases, postoperative death rate
      (author's transl)].
AB  - The early death rate after lung-resections is caused mainly by right heart
      failure. The level of pulmonary blood pressure plays a decisive role in this
      respect. In patients with surgical lung diseases the blood pressure is
      significantly higher in several parts of lung circulation than in healthy
      persons. The early death rate after operation was found to be increased in
      patients with a higher level of preoperative pulmonary artery pressure.

PMID- 1020351
TI  - [Pulmonary artery pressure in the pathophysiology of lung-resections therapy.
      Part II: bronchial carcinoma and pulmonary tuberculosis (author's transl)].
AB  - Patients with lung resections due to bronchial carcinoma have a much higher early
      death rate than patients with lung resections because of pulmonary tuberculosis.
      Functional failure of the cardiorespiratory system and right heart insufficiency
      are considered to be the main reasons for this difference. Intracardial pressure
      values were compared between 530 patients with bronchial carcinoma and 200
      patients with pulmonary tuberculosis revealing significantly higher pressure
      values in the right heart and pulmonary artery for patients with bronchial
      carcinoma. Predisposing factors of the aged people are fundamental in this
      respect.

PMID- 1020352
TI  - [Pulmonary artery pressure in the pathophysiology of lung-resections therapy.
      Part III: pre- and postoperative investigations (author's transl)].
AB  - 50 patients were investigated by right heart catheterization to determine the
      range of blood pressure values in lung circulation after lung resection. A
      comparison between pre- and postoperative blood pressure values was conducted in
      29 patients and a significant increase was found. In some patients the blood
      pressure values after pulmonary lobectomy rose to 50% and after pneumonectomy to
      100% above the preoperative values. Changes of the investigated aterial pressure
      differences proved to be not statistically significant.

PMID- 1020353
TI  - [Relation between manifest bronchial obstruction and bronchial hyperreactivity
      (author's transl)].
AB  - Based on the inquiry of 252 patients an investigation was carried out concerning
      the frequency of manifest bronchial obstruction in dependence on the bronchial
      hyperreactivity. Patients with bronchial hyperreactivity showed more frequently
      with a high significance as well a decrease in the FEV1 as an increase of
      resistance. Therefore in dependence on the occurrence of a manifest bronchial
      obstruction also the probability of a simultaneous presence of bronchial
      hyperreactivity increases. The results are important for understanding the
      functional dynamics of the bronchopulmonary system, especially the evocation of
      dyspnea by irritation of the respiratory tract.

PMID- 1020354
TI  - [Evaluation of the tussicular reaction in bronchial provocative testing with
      acetylcholine (author's transl)].
AB  - A simple method for registration of the tussicular effect in bronchial
      challenging is described. The results, obtained in this way, are discussed for
      their informative value. In bronchial challenging with acetylcholine tussicular
      reaction in all groups of patients is more frequent than broncho constrictive
      reaction. Evaluated on clinical defined diagnoses respectively anamnestic date
      there is a good sensibility of the test (index for sensibility 0.85). Till now
      the date of specifity are not satisfying. It could be solved only by means of
      longitudinal studies, if these "false-positive" results have an early diagnostive
      value with regard to beginning functional disturbances in the airways or if they
      coincide with diagnostic uselessness of the test.

PMID- 1020355
TI  - [Contribution on prevention, diagnosis and treatment of pulmonary embolism
      (author's transl)].
AB  - In the 50 year period between 1917 and 1966, 915 patients, 0.44% of the total
      surgical patients at the Surgical Clinic of the University of Jena, died from
      pulmonary embolism. In 20% of the cases autopsy failed to disclose any thrombus.
      Among 714 fatal cases of postoperative lung embolism, 43% occurred after
      abdominal surgery, 18% after surgery on the extremities, and 14% followed
      urogenital operations. Peak incidence of lung embolism fell on the day of
      operation and on the 6th, 7th, and 13th postoperative day. Patients at risk of
      embolism can be identified beforehand. The incidence of pre- and postroperative
      pulmonary embolism can be reduced to a great extent by specific preventive
      measures carried out prior to, during, and after surgical intervention.
      Prevention, diagnosis, and present day treatment of pulmonary embolism are
      discussed.

PMID- 1020356
TI  - [Rise in incidence of pulmonary embolism fatalities among surgical patients and
      disposing factors involved. Analysis for a 50 year period (author's transl)].
AB  - During the 50 year period from 1917 to 1966, 210078 patients were treated in the
      Surgical Clinic of the University of Jena. Autopsies were carried out on 10083 of
      the patients which had dies in the Clinic. The average incidence rate of lung
      embolism was 0.44%, the range of values lying between 0.04% (1917) and 1.02%
      (1965). In periods of famine or distress, lung embolism reached its lowest point,
      whereas in periods of relative prosperity a high peak was reached. On the whole,
      the incidence of pulmonary embolism seem to be the increased age of the patients
      population and the higher frequency of associated heart and circulatory diseases,
      obesity, and accidents, as well as the extended indications for surgery in the
      aged.

PMID- 1020357
TI  - [Mediastinoscopy in preoperative assessment of operability in patients with
      bronchial neoplasms (author's transl)].
AB  - The results and conclusions of the endoscopic exploration of mediastinum in 352
      patients suffering from bronchogenic cancer are analysed. The importance of
      mediastinoscopy is emphasized especially in the assessment of operability. In the
      opinion of the authors the cancer is not operable, if metastases are found in the
      paratracheal and contralateral lymphnodes. Only in young men the extended
      resection should be done in individual cases if mediastinal lymphnode metastases
      are detected. Regarding these indications the rate of explorative thoracotomy
      could be reduced to 10%. The particular importance of preoperative examination of
      load capacity of the heart and circulatory system is stressed. Finally it is
      concluded, that an decisive improvement of the common prognosis of the
      bronchogenic cancer is only possible by an earlier detection and a more rapid
      introduction of therapy, but not by the extension of the surgical procedures. The
      enlargement of the surgical procedure should be decided individually. The great
      possibilities hencefollowing for the mass x-ray examinations are emphasized.

PMID- 1020358
TI  - [Complications of mediastinoscopy and their effects on the choice of indication
      (author's transl)].
AB  - Complications of 735 mediastinoscopies are evaluated. In the small number of
      early complications the bleedings and unjuries of pleura dominate in the
      described group of patients. At no time a thoracotomy was necessary. The danger
      of bleeding from an aneurysma of the aorta is pointed out, which is rare but
      possible early complication. The inoculated metastases do not deteriorate the
      prognosis of the bronchogenic cancer, if the mediastinoscopy is strictly limited
      to the paratracheal and tracheobronchial lymphnodes. The observation of a
      metastasis in the collar cicatrix following three months after mediastinoscopy
      due to cancer of the oesophagus is described. The low number of observed
      complications in the opinion of the writers does not justify to limit the range
      of indications for mediastinoscopy, its diagnostic value is high.

PMID- 1020359
TI  - [Acute courses of sarcoidosis which clinically appeared as rheumatic diseases
      (author's transl)].
AB  - After a short review on the manifold relations between rheumatic and pulmonary
      diseases this aspect is exemplified in detail by acute sarcoidosis. Report on 31
      patients with Loefgren-Syndrome, admitted to the rheumatologic-cardiological
      clinic between 1968 to 1973, nearly all with the suspicion of rheumatic fever.
      Their symptoms, clinical findings as well as the diagnostic programme carried out
      is described.

PMID- 1020360
TI  - [Clinical picture of a generalized BCG vaccination tuberculosis as an expression
      of a progressive septic granulomatosis (author's transl)].
AB  - Report on a boy, now 3 years old, who presented the typical clinical picture of a
      BCG generalization during infancy. The BCG agents were verified in the lymph
      node. Intensive tuberculostatic therapy in combination with the transfer factor
      failed. The negative NBT test revealed a progressive septic granulomatosis.

PMID- 1020361
TI  - [Effectivity of intermittent RMP/EMB treatment in patients with chronic pulmonary
      tuberculosis (author's transl)].
AB  - 59 patients with far advanced chronic pulmonary tuberculosis were treated, after
      a three months daily period of RMP/EMB and a third drug, with RMP 1.2 g and EMB
      50 mg/kg twice weekly for the following 9 months and there after with EMB 50
      mg/kg twice weekly for another 12 months. Sputumconversion was achieved in all
      patients within four months. Except for one bacteriological relapse during the
      10th month of therapy all patients were TB-negative up to the end of at least
      four years (4-6 1/2 years) after onset of treatment. In nearly 78% of the
      patients the treatment was fully accepted and well tolerated during the first
      year. 8 patients had systemic reactions due to RMP between the 7th and 12th
      month. Only in 5 patients RMP had to be substituted by another drug. The regimen
      has proved to be highly effective, well acceptable and tolerable. It could be
      administered fully supervised.

PMID- 1020362
TI  - [Effectivity of intermittent treatment in patients with sputum-positive silico
      tuberculosis (author's transl)].
AB  - 89 patients with sputum-positive silico-tuberculosis got a fully supervised
      administered antituberculous treatment with intermittent regimens during the
      years 1969-1974. 65 of the patients had a history of former antituberculous
      treatment. In only 5 patients the treatment was unsuccessful. Four of the
      relapses were observed between the 6th and 11th month of treatment. One patient
      had a relapse 56 months after the onset of chemotherapy. The results indicate
      that only the quality of the anti-TB treatment is of importance for the course of
      the tuberculous component in silico-tuberculosis. The results are comparable with
      those of uncomplicated TB of the lungs.

PMID- 1020363
TI  - [Malformations of the lung with abnormal hemodynamics (author's transl)].
AB  - The various forms of combinations of bronchopulmonary and pulmonary vascular
      abnormalities are classified by their special hemodynamic. They are called
      "pulmonary malformations with abnormal hemodynamics". 11 cases were observed,
      operated and analysed.

PMID- 1020364
TI  - [Compensative dilatation of the vena azygos by abnormalities of the vena cava
      inferior - a contribution to the differential diagnosis of the tumorsuspected
      right tracheobronchial angle (author's transl)].
AB  - Report on 2 patients, with a mediastinal enlargement at the right
      tracheobronchial angle revealing an ectasis of the orifice of vena-azygos. It
      could be shown that the enlargement of the vena azygos ist due to an increase of
      the flow-volume, caused by an abnormal embryonic drainage of the vena cava
      inferior into the vena azygos. The diagnostic possibilities for differentiation
      from vascular and nonvascular space-occupying processes in that region are
      discussed. An exact diagnosis is possible by angiography.

PMID- 1020365
TI  - [Rationalization and standardization in the diagnostic of pleural effusions
      (author's transl)].
AB  - 238 pleural effusions found within five years among our patients were
      investigated according to a prospective fixed scheme, and analysed according to
      diagnostic groups. In accordance with other authors a predominance of the
      malignant pleural effusions was evident. Besides the cytohistologic diagnosis
      proving 84,6% of the pleural effusions of malignant origin, some of the
      biochemical parameters are of decisive value. In our opinion laboratory
      examinations should be abandoned which do not contribute effectively to establish
      the diagnosis. For rationalization a routine programme with five examinations is
      being proposed: total protein and specific gravity, pH, bacterial examination and
      cytology.

PMID- 1020366
TI  - [Contribution on the chronic fibrinous bronchitis (author's transl)].
AB  - The present report deals with an actual case of the rare chronic fibrinous
      bronchitis. With references to previous publications on this subject the picture
      of the disease is described on the basis of an actual case. A review of the
      literature available and the investigation of the actual case have led to
      parameters of the disease mentioned, which are typical and indicative of this
      disease. It has been found out that chronic fibrinous bronchitis is diagnosable
      by clinical means. Problems concerning the therapy, prognosis and etiology are
      discussed.

PMID- 1020367
TI  - [Results of comprehensive respiratory function tests in CNSLD (author's transl)].
AB  - 34 persons with CNSLD, but fit for work, were examined with the aim to record the
      degree of disturbance of pulmonary function and the underlying pathophysiological
      mechanism. The results were compared with 30 healthy subjects. The following
      function tests were carried out under resting conditions and bicycle ergometer
      exercises: Analysis of ventilation (FVC% pred., FEV1% FVC, RV% pred., RV% TLC),
      analysis of lung mechanic (Raw, CL) measurement of diffusion (DL, DM, Vc, DL%
      pred.) and analysis of lung inhomogeneity (RE/REO, V2/V1, CL6/CL100,
      deltaFN2/deltaV500, deltaFCO2/deltaV500,IHB). The results were analyzed and
      evaluated by using the digital computer C 8205. Persons suffering from CNSLD were
      showing among typical clinical symptoms the following disturbances of lung
      function: The obstructive ventilation disturbance stands in the foreground in
      connection with signs of inhomogeneity of lung mechanics and ventilation. While
      the resistance already shows the airway obstruction objectively under resting
      conditions, the decreased compliance is measurable at first under exercise. The
      disturbance of diffusion, which is pointed out, is mainly a latent decreased
      diffusing capacity of alveolo-capillary membrane. These disturbance of diffusion
      gets more importance because the inhomogeneity of lung hides the real disturbance
      of diffusion. The pathophysiological consequence of disturbed partial functions
      of respiration is the latent hypoxaemia without hypercapnia, therefore the signs
      of respiratory partial insufficiency.

PMID- 1020368
TI  - Intestinal absorption of iron alone and in combination with authentic or natural
      vitamin C and carotene.
AB  - The effect of vitamin C and carotene derived from authentic or natural sources on
      intestinal iron absorption was studied. Vitamin C caused slight enhancement to
      iron absorption, while carotene hindered it. The three juices tested, namely
      orange, parsley and pepper, which were found to be rich in these two vitamins,
      hindered intestinal iron absorption to different extents. It was recommended that
      patients suffering from iron deficiency are not supplied with nutrients rich in
      carotene particulary during iron therapy.

PMID- 1020369
TI  - The use of Lupinus termis L. cultivated in Egypt, as a food protein supplement.
AB  - 1. General analysis of the seeds for protein, fats, carbohydrates, fiber and ash
      contents were carried out and the results were given in g/100 g dry seeds.
      Lupinus termis contained a higher percentage of protein (40.36), 290 mg calcium
      and 6.5 mg iron. 2. All the essential amino acids are present in fair amounts
      with the exception of sulphur-amino acids and Lysine. 3. Cooking the seeds
      resulted in a slight decrease of most of the amino acids with the exception of
      Tryptophan and Lysine, which exhibited a slight increase after cooking. 4. Of the
      toxic substances present in the seeds is Trypsin inhibitor, which was destroyed
      by heat treatment, and alkaloids, which were removed by soaking the seeds three
      days in running tap water. 5. Supplementing the debittered seeds with Lysine and
      Methionine resulted in an increase in its nutritive value.

PMID- 1020370
TI  - [Electrolyte metabolism in obese subjects with various forms of therapy].
AB  - In 30 obese subjects three different methods for weight, reduction were
      applicated over a period of 14 days. One group (n=10) was treated with total
      starvation, the other group (n=10) with total starvation and 80 mval potassium in
      addition and the third group (n=10) with a 700 cal. diet. In total starvation the
      balance of sodium, potassium and phosphate amounted to -9 mval/d, -34,9/d and 
      8,8 mval/d respectively. Whereas calcium showed a positive balance of 4,4 mval/d.
      During addition of 80 mval potassium sodium excretion increased whereas potassium
      excretion was diminished resulting in a potassium balance less negative. During
      treatment with the 700 calorie diet the highest negative sodium and a high
      positive potassium balance were observed,

PMID- 1020371
TI  - Comparison of xylitol and glucose metabolism in nonhepatic rat tissues.
AB  - Capability and extent of xylitol metabolism in vitro was studied in a variety of
      non-hepatic tissues of rats, using enzymatic and isotopic methods. Only kidney
      was found to be able to utilize xylitol at a significant rate while in all other
      organs tested - lung, brain, heart muscle, skeletal muscle and adipose tissue -
      no uptake of xylitol was detectable using two independent methods. In accordance
      with these results the incorporation of radioactivity from [U-14C]-xylitol as
      substrate into the products CO2 and lactate was found to be very small in all
      organs with the exception of kidney and when compared to that from [U-14C]
      glucose it was less than 5%. From these results it is concluded that besides
      liver only kidney can utilize xylitol to a significant extent while for the other
      tissues studied xylitol is not a suitable substrate.

PMID- 1020372
TI  - [Comparison of time, material and preparation costs as well as nutritive value of
      conventionally prepared soups and sauces and corresponding "convenience foods"].
AB  - In a survey the food and labour costs arising in connection with the preparation
      in feeding centers - with about a thousand dinners - of conventionally cooked
      soups and sauces and corresponding convenience food were determined. For soups
      food costs are lower for convenience food than for conventionally prepared soups.
      Regarding the sauces, the costs of one of the two preparation manners is not
      definetely more favourable than the other one. The cost scheme will shift to the
      disadvantage of convenience food whenever it has to be modified in default of a
      comparable product, as for instance in the case of bechamel-sauce and horse
      radish sauce. Considering the factor time, convenience food will be unambiguously
      superior to conventionally cooked soups and sauces. The preparation of
      convenience soups takes only between one fifth and one eighth of the necessary
      time for the preparation of conventionally, of sauces only between one sixth and
      one twelfth of the required time. Soups and sauces made out of convenience food
      have a lower energy content than the conventionally cooked ones.

PMID- 1020373
TI  - Nutritive studies on some raw and prepared leguminous seeds commonly used in the
      Arab Republic of Syria.
AB  - 1. The proximate analysis of raw Syrian lentils (Lens esculentus), variety red
      chick pea (Cicer arietinum) variety balady, has been made. The protein content of
      the two raw seeds were 23 and 22 g% for lentils and chick peas, respectively.
      Ethereal extract, fiber, ash, calcium, phosphorus and iron content of the two raw
      seeds have been also assayed. 2. The levels of most of the amino acids were also
      estimated in the raw and cooked seeds. It was found that tryptophan- and sulphur
      containing amino acids were the most limiting ones. Cooking the seeds by the same
      methods commonly used in Syria resulted in the loss of most of the amino acids,
      with the exception of lysine and tryptophan which were slightly increased. 3.
      Trypsin inhibitors and saponins were detected in the raw seeds. Haemagglutinins
      were present in raw lentils only. Cooking the seeds destroyed the trypsin
      inhibitors and haemagglutinins and did not affect the saponins. 4. The net
      protein utilization of whole lentils and chick peas were 38 and 53, respectively.
      Decortication of lentils or cooking without decortication has no effect on the
      NPU values. Cooking the decorticated lentil seeds raised its NPU values from 38
      to 56. Cooking chick peas resulted in a slight increase in their NPU.
      Supplementation of the raw and treated seeds with methionine and tryptophan
      raised its NPU values markedly.

PMID- 1020374
TI  - Effect of vitamin C and carotene on the absorption of calcium from the intestine.
AB  - The effect of vitamin C or carotene either in the authentic form or naturally
      occurring as in orange, parsley and pepper juices on calcium absorption was
      studied. Results obtained revealed that ascorbic acid, orange and pepper juices
      enhanced intestinal calcium absorption. Carotene and parsley proved to be without
      effect.

PMID- 1020375
TI  - [Lupine, a contribution to the human food supply. 4. Acceptability of Lupinus
      alba flour].
AB  - 48 different dishes enriched with lupinus albus flour have been tested by 20
      persons. The test duration has been 4 weeks. Meals and products with lupine
      admixtures have been judged equally with concern to corresponding conventional
      dishes. Farinaceous products had the best test results. Therefore, it is
      recommended for Peru to add lupine flour when producing bread, biscuits, sauces,
      soups, and noodles (maccaronis etc.). The test time had no influence to the test
      results.

PMID- 1020376
TI  - [General problems in the diagnosis of cancer].
AB  - Cancer distingishes itself from other chronic diseases in internal medicine by
      the chance of complete and constant cure in "early" recognition and treatment.
      The well-timed diagnosis, therefore, is decisive for the fate of the patient.
      This increases the responsibility of the internist. Early recongnitionof the
      cancer by well planned medical check-up meets with close boundaries and is
      nowadays only justified for malignant tumours of the cervix uteri, the mammary
      gland, the stomach and the lung. The dispensary care of risk groups favours the
      higher quality of the work of the physician, but is not able to reduce decisively
      the problem. The dispensary care has important functions in the field of health
      education and thus also aims at the primary prevention. Quick and relevant
      diagnostics in complaints is at present and in near future the most important way
      to the recognition of cancer in the curable stage. Careful general examination of
      the body and aimed questioning after danger signals independent of the reason of
      the consultation may improve the situation. Apart from the recognition of the
      cancer the disribution diagnostics and the judgment of the general resistance to
      stress are responsible tasks of the internist.

PMID- 1020377
TI  - [The paraneoplastic syndrome].
AB  - The notion of the paraneoplastic syndrome contains a great number of signs which
      are not to be explained by the local growth of the tumour. The disturbances may
      express themselves in form of fever, anorexia and cachexia, or they may also
      affect selectively determined organs. As a cause for these tumour-associated
      changes, apart from unspecific and specific metabolic functions of the tumour
      cell, also the sequelae of immunological reactions between tumour and host
      organism are made responsible. The metabolic remote action of malignant
      neoformations proved as clearly manifest above all in the paraneoplastic
      endocrinopathies. Though most of the paraneoplastic syndromes are not strongly
      specific for the tumour their knowledge may be significant in the diagnostics and
      control of the course of neoplasias. This is also the case in emergency
      situations which can be evoked by such pathological processes. The most important
      paraneoplastic syndromes and problems of their pathogenesis are explained.

PMID- 1020378
TI  - [The importance of endoscopy in oncology].
AB  - The importance of the praetherapeutic histological manifestation of tumours is
      emphasized. In many cases for this purpose an endoscopy with biopsy is necessary.
      A particular role plays the endoscopy in urology, bronchology and
      gastroenterology. The endoscopy significantly developed by the introduction of
      fully flexible glass fibre endoscopes. This particular considers the
      gastroenterology. Several regions, such as the duodenum, the small intestine and
      the colon, were thus first accessible to endoscopic biopsy. Indications and
      possibilities of the individual endoscopic methods are mentioned. As to the
      question, who individually should perform the endoscopy, the opinion is expressed
      that every specialist should perform the endoscopy in his field. The performance
      of all endoscopic methods by one specialist, independent on the speciality,
      actually gives some technical advantages, which, however, do not compensate the
      disadvantages concerning a qualified total diagnostics of the diseases. During
      the last years by the removal of the polyps the endoscopy in an increasing stage
      also becomes a therapeutic method. At present the technical possibilities of
      endoscopy came to a certain close. By all means necessary is, however, the
      further distribution of the endoscopic methods which depends on the availability
      of adequate endoscopes.

PMID- 1020379
TI  - [Nuclear medicine in tumor diagnosis].
AB  - After introductory comments on the principle of the tumour scintigraphy and the
      factors influencing the scintigraphic demonstration the author adopts a definite
      attitude to the scintigraphy of thyroid gland, brain, lung, liver pancreas,
      kidney, bone, spleen as well as lymphatic nodes, liquor spaces and adrenal glands
      from the point of view of tumours diagnostics. For the purpose of a better survey
      for the first seven organs uniquely the problems are demonstrated according to
      the principle of examination, method of examination, indication to the tumour
      diagnostics, preliminary examination and prerequisite to the scintigraphy, the
      problems of scintigraphy and the functional capacity of other methods.

PMID- 1020380
TI  - [Age-corrected analysis of glucose tolerance in blood relations of patients with
      juvenile onset diabetes mellitus].
AB  - Intravenous glucose tolerance test(taking the age dependent variabilities of the
      glucose assimilation into consideration) was performed in 68 blood relations (30
      siblings, 19 parents, 19 children) of 19 patients with juvenile onset diabetes
      mellitus (JODM). In 29,4% of the first degree relatives (in 20% of the siblings,
      in 42% of the parents and in 31,6% of the children) an abnormal glucose tolerance
      was found. Four of the siblings presented with insulin dependent JODM. Glucose
      intolerance was detected more often (42%) in siblings and parents of patients
      with later onset (after age 25) JODM than in siblings and parents of JODM
      patients with onset before age 25 (20%).

PMID- 1020381
TI  - [Longitudinal study on the locomotor function test in patients with rheumatoid
      arthritis].
AB  - With  the help of a four-year observation of the course of rheumatoed arthritis
      in 100 patients the evidence of the locomotor functional test after Keitel is
      examined for the longitudinal research. The locomotor functional test proved
      depending on the actual activity and in a high percentage of patients showed
      considerable variations from year to year which were not parallel to the clinical
      and radiological progression. It is not sufficiently evident as the only
      criterion for the establishment of the progression of the disease. The locomotor
      functional test is well suited for the  judgement of the success of therapy in
      short periods and the objectivation of the actual restriction of the function
      especially for questionings of experts. It is proposed to include the locomotor
      functional test into the criteria for the establishment of the degree of
      function.

PMID- 1020382
TI  - [Contribution to the clinical picture of Wegener's granulomatosis].
AB  - On the basis of 5 casuistics of Wegener's granulomatosis the author deals with
      the difficulties of the diagnosis and differential diagnosis, whereby above all
      is referred to the preculiarities of the cases and the malinterpretation of the
      diagnoses on admission to the hospital.

PMID- 1020383
TI  - [Functional study on the sense of smell in patients with chronic liver disease].
AB  - In olfacto-odorimetrical examinations of 32 patients with chronic liver diseases
      (18 female and 14 male patients at the age of 23 to 77 years) 13 patients with a
      disturbed olfactory function were found. With one exclusion these patients
      suffered from liver cirrhosis. On the basis of the anamnesis in 10 of these
      patients a causal connection between disturbance of smelling and liver disease
      could be assumed. Out of this group with chronic active hepatitis of 10 patients
      only 1 patient had a disturbed olfactory function. In 8 patients with disturbed
      olfactory function suffering from liver cirrhosis a comparison of the
      olfactometrical findings with activity of GOT and GPT in the serum and the serum
      bilirubin content showed a correlation between possibilitiy of smelling and serum
      bilirubin level. Possible causes of appearing olfactory disturbances are
      demonstrated in short.

PMID- 1020384
TI  - [The primary gallbladder neoplasm].
AB  - From 1960 to 1975 in the Surgical Clinic of the Medical Academy Erfurt altogether
      77 patients with a primary malignoma of the gall-bladder were observed.
      Symptomatology and findings are non-characteristic. 64 times a laparotomy was
      carried out, whereby in 51 cases the intervention had to be finished as test
      laparotomy. 13 times a cholecystectomy or a biliodigestive anastomosis was
      carried out. The average survival time of the patients with test laparotomy was
      53 days. A survival time of more than one year could nertainty. Issuing from this
      the author adopts a definite attitude to carcinogenesis and the importance of
      lithiasis.

PMID- 1020385
TI  - [The reproducibility of the acetylcholine test and the effect of the respiratory
      flow rate].
AB  - The reproducibility of the acetylcholine-test results was controled by means of
      comparative investigations on 50 patients. The method of investigation render it
      possible with a high reliability to exclude a bronchial hyperreactivity. However,
      a single positive diagnose needs an additional control examination with reference
      to the interpretation of evidence. The different test results are caused by the
      biological variability of the bronchial hyperreactivity; on the other hand, an
      influence of variability of the minute output of breathing could be excluded.

PMID- 1020386
TI  - [Learning gastroenterologic endoscopy].
AB  - 1. Knowledge of the gastroenterological endoscopy and biopsy is necessary at all
      levels of medical education. 2. Knowledge of students: possible methods,
      diagnostic effectiveness, stress of the patients. Knowledge of the candidates for
      specialisation: indications, contraindications, possibilities of the method also
      in reference to the individual case. Persons interested in the subspecialisation
      gastro-enterology: theory, possibilities and limits, technical performance.
      Experienced endoscopists: regular refreshment and supplementation of knowledge
      and skill in highly specialised endoscopic centres. 3. Tested teaching methods
      are lecture, report, study of atlants and text-books, demonstrations of
      diapositives in connection with schematic figures, seminars with diapositives,
      film demonstrations, work at the patient under supervision of the tutor and use
      of a demonstration device as well as endoscopic demonstration by means of colour
      television. The centre is, however, the individual examination of the patient. 4.
      Knowledge of the subspecialist: History of endoscopy, knowledge of instruments,
      optics and endoscopic perspective, physical fundaments about light and
      photography, human macro- and microscopic anatomy, care of instruments and
      desinfection. Indications, contraindications, possibilities and limits of the
      method, emergency and intensive medicine, writing of the findings.

PMID- 1020387
TI  - [The value of aimed biopsy in gastroscopy].
AB  - The introduction of the fiberscops with the possibility of the aimed biopsy has
      considerably improved the diagnostic evidence of gastroscopy, though there exists
      a whole series of technical problems in the histological ascertainment. Though
      all regions of the stomach are accessible to the biopsy forceps, the histological
      findings cannot always be ascertained clearly histologically. Of 105 carcinomata
      of the stomach and the oesophagus only 84 were verified clearly histologically.
      Of 101 ulcers appearing benign five proved to be malignant in histological
      respect. In 14 scars in two cases a carcinoma could be proved. Altogether from 27
      polyps appearing benign bioptic material was taken, which in all cases confirmed
      the primary diagnosis, nevertheless at the operation one polyp proved to be
      malignant. In 105 cases endoscopically the diagnosis of a carcinoma was made, but
      in seven cases it was a benign ulcer clearly confirmed by the operation. It is
      reported on some own experiences concerning the improvement of the result of the
      aimed biopsy.

PMID- 1020388
TI  - [The gastroscopic diagnosis of early stomach carcinoma].
AB  - A short report is given on the development of diagnostics of early gastric
      cancers, whereby it is especially referred to the importance of the Japanese
      investigations of this phenomenon. The notion of the early carcinoma for gastric
      carcinomata which have affected only the mucous membrane or only in a slight
      degree the submucosa is widespread. But it contains a notion of time which is
      falsely presumed. As we at present do not certainly know, whether the early
      gastric carcinomata, all over the world known as "early cancer", really could not
      fail in developing to advanced gastric carcinomata, the name "early" carcinoma is
      questionable. Concerning this question further investigations are necessary,
      which should be directed to the definition of a risk group of gastric cancer.
      Finally is reported on own results in the diagnosis of 12 early gastric cancers.

PMID- 1020389
TI  - [The so called early stomach carcinoma and its histological definition].
AB  - The histological findings of twenty bioptically diagnosed early cancers of the
      stomach are described. In the delimitation of the so-called borderline-lesions
      the intestinal metaplasia in the mucous membrane of the stomach must particularly
      be taken into consideration. The differentiated ripe form of the intestinal
      metaplasia is no precancerosis. However, within the process of intestinalisation
      atypias may appear, which represent possible transitional forms to carcinoma.

PMID- 1020390
TI  - [Deep duodenoscopy and endoscopic retrograde cholangiopancreaticography].
AB  - A survey is given on indications, results and complications of the deep
      duodenoscopy and endoscopic retrograde cholangiopancreaticography. The endoscopic
      retrograde pancreatography is indicated in the chronic forms of pancreatitis, in
      suspicion to cysts of the pancreas or tumours. Its results have a decisive
      influence on the indication to surgical procedure and on the planning of the
      intervention. The endoscopic retrograde cholangiography is of greatest practical
      significance for the differential diagnosis of the cholestatic icterus: non
      obstructed bile ducts exclude an extrahepatic icterus and render a laparotomy
      useless. Furthermore, the endoscopic retrograde cholangiography is indicated when
      the demonstration of the duct is intravenously insufficient, when papillary or
      prepapillary narrowings are present and in the etiologically unclear syndrome of
      postcholecystectomy. The most dangerous complications of the endoscopic
      retrograde pancreatography are the acute pancreatitis and the infection of cysts.
      Cholangitides and septicaemias appear after the endoscopic retrograde
      cholangiography only in such cases when obstructions of the drainage are present.

PMID- 1020391
TI  - [Experiences with coloscopy].
AB  - The introduction of fully flexible coloscopes has considerably contributed to the
      improvement of the diagnostics of the large intestine. According to the hitherto
      got experiences is to be expected that this method will contribute to the
      possibility of diagnose malignant and benign colon processes earlier and more
      exactly. In the paper the methodology of the coloscopy is described and it is
      referred to its difficulties and complications. The indications and
      contraindications for the coloscopy are described. It is reported on first
      results after a one-year experience with coloscopy. The conclusion is that in
      patients with radiologically and rectoscopically not clarifiable, referring to a
      severe disease of the colon, symptoms a coloscopy should be carried out.

PMID- 1020392
TI  - [Vital microscopic investigation of terminal blood vessels in patients with
      diabetes mellitus].
AB  - It is reported on findings of vital-microscopic investigations at the terminal
      vascular system of the conjunctiva bulbi and the mucous membrane of the lips
      carried out on 50 juvenile diabetics and 50 test persons of the same age. By
      quantitative establishment of the morphological and functional changes of the
      vessels and the aggregation of the erythrocytes in the different regions of the
      terminal vascular system we succeeded in delimitating all 50 diabetes as
      individuum or as collective (x equals 10.7 +/- 1.5) from the test persons (x
      equals 3.4 +/- 0.9) by means of a point system (p less than 0.001). In 4 figures
      typical vascular findings are demonstrated. No pathognomonic significance was
      ascribed to the individual vascular findings. The morphological and functional
      changes of the vascular wall are regarded as an expression of fundamental
      reactive possibilities of the vessels of the terminal vascular system after
      influence of different factors of risk. As criteria of the findings were used:
      venular sacculations, meander-like forms, convolutions, haemorrhages, aneurysms,
      reticular structures, varieties of calibres, changed arteriolarvenular relations
      of the inner diameter of the vessels, constant proof of aggregates of
      erythrocytes with temporary standstill of the flow in the different parts of the
      terminal vascular system. The author is of the opinion that with simultanuous
      establishment of the morphological and functional changes of wall of the vessel
      and content of the vessel degenerative changes in diabetes mellitus are provable
      earlier than at the eye-ground by means of ophthalmocoscopy when only
      morphological findings are established. The reciprocities between the vascular
      changes and the rheological properties of the blood are described.

PMID- 1020393
TI  - [Results of different long term treatments of patients in the early stages of
      rheumatoid arthritis].
AB  - In a clinical 5-year-study on 200 patients with rheumatoid arthritis with the
      help of the dynamics of radiological changes (radiological progressing), the
      joint deformation, the reduction of function and the new affection of joints
      (clinical progressing) as well as the medium position of activity the progressing
      of the disease and a good, satisfying or missing success of the long-term therapy
      were estimated. From the characteristics of the individual groups of therapy
      conclusions for the therapy in the early phase of the rheumatoid arthritis were
      derived.

PMID- 1020394
TI  - [Plethysmographic investigation of the post-thrombotic syndrome].
AB  - In 49 patients with a phlebographically ascertained postthrombotic syndrome, who
      were above all subdivided into morphologically defined degrees of severity, after
      May and Nissl, a plethysmographic investigation was carried out with the deep
      positioning test and the venous drainage test. The results were contrasted with a
      group of 53 patients with a primary varicosis and the measuring results of 102
      test persons with healthy veins. A very good correlation between the
      morphological changes and the haemodynamic findings establishable by means of the
      phlebembraxis plethysmography could be proved. A clear evidence was possible by
      means of the venous drainage test, whereas in the deep positioning test a certain
      demarcation was possible only in stage III of the postthrombotic syndrome.

PMID- 1020395
TI  - [Smoking and the change in leukocyte count].
AB  - In 20 smokers and non-smokers the effect of one cigarette on the total number of
      leucocytes, the absolute number of basophilic granulocytes and on the basophil
      age-index was investigated. The reduction of the BAI was ascertained in smokers
      at the 5%-level and in non-smokers at the 1%-level. The number of leucocytes was
      significantly increased in smokers. The reduction of the total number of
      leucocytes by smoking was ascertained in smokers at the 1%-level, in non-smokers
      at the 5%-level. Adaptation mechanisms as well as the importance of the findings
      for the pathogenesis of arteriosclerosis and smoker bronchitis are discussed.

PMID- 1020396
TI  - [Blood circulation disturbances of the upper extremities as a principle symptom
      of pseudoxanthoma elasticum].
AB  - The pseudoxanthoma elasticum is a rare disease of the connective tissue which
      coincides with typical symptoms of the skin, eyes and vessels. It is reported on
      a 37-year-old female patient that showed disturbances of the blood circulation in
      the upper extremities as a main symptom.

PMID- 1020397
TI  - [Case report on the problem of individual glycoside requirements].
AB  - A report is given on a patient with ischaemic heart disease, whose recompensation
      in tachyarrhythmia absoluta was for some times possible only by means of
      unusually high doses of digitoxin (fully effective dose to 5.72 mg, maintenance
      dose to 0.4 mg). The patient survived a severe decompensation with pulmonary
      oedema, which appeared under "normal" applications of glycosides, 2 1/2 years
      under this therapy. Thus it must again be referred to an individual glycoside
      treatment.

PMID- 1020398
TI  - [Molecular mechanisms of the biological effects of UV radiation].
AB  - The biological processes taking place in the biosphere are for the largest part
      bound to the existence of ultraviolet-rays in form of sun rays. Here the
      furthering effect of the UV-rays on origination, maintenance and further
      development of life processes is contrasted by the harmful influences of the UV
      rays. With the help of the hitherto known facts the primary and consecutive
      processes which underlie the biological effects of the UV-rays are discussed on
      molecular level. Furthermore, the possibilities of repairing these lesions caused
      by UV-rays as well as the biological consequences when repair damages are present
      are discussed. Finally on the basis of experimental examinations the author deals
      with the problems of the ultra-violet radiation of the blood.

PMID- 1020399
TI  - [The place of adrenal angiography (phlebography and arteriography) in the
      diagnostic stepwise program in arterial hypertension].
AB  - Arteriographical and phlebographical methods are distinctly suited for the
      diagnostics of the adrenal glands in the stop program of the combat against
      hypertension. Hypervascular tumours of the adrenal medulla, especially
      phaeochromocytomata may be established arteriographically relatively certainly.
      Avascular processes of the adrenal cortex, however, are better to be diagnosed by
      the selective phlebography of the adrenal glands. The phlebography is also suited
      for the planimetric determination of the size. The following uncorrected normal
      values were established: on the left m1 = 10.58 +/- 1.17 cm2, on the right m2 =
      6.95 +/- 1.39 cm2. The mean value of normal couples of adrenal glands is M =
      18.17 +/- 1.96 cm2. The left adrenal gland is statistically significantly larger
      than the right one (p greater than 0.001). In 214 patients altogether 44
      selective arteriographies and 276 selective phlebographies of the adrenal glands
      were performed. As angiographical basis examination of all patients was at first
      performed an abdominal aortography or an angiography of the kidneys. The
      phlebographical diagnostics was successful on the left in 98.7% and on the right
      in 90.4% of the cases. 72 patients had pathological processes of the adrenal
      glands, out of them 20 times a solitary adenoma of the adrenal glands was
      present. 38 patients had a one- or double-sided hyperplasia, and 4 patients had a
      phaeochromocytoma. In 10 other cases more infrequent changes were found.

PMID- 1020400
TI  - [Screening of collagen diseases in the years 1961-1972 from a selected population
      sample].
AB  - In our article is referred to the recognition of collagenosis in the demarcated
      whole district with 100,000 inhabitants. The occurrence of these diseases is
      lower than the occurrence of other rheumatic diseases. Our results as well as the
      observations of other authors confirm that the lupus erythematodes and the
      diffuse sclerodermia are not rare diseases even in our circumstances and with
      their evolution tendency they shorten the lives of the affected persons. The high
      recognition coefficient with large probability corresponds to the real incidence
      of these two diseases, which can be achieved only by an observation of many years
      and repeated controls of the correctness of the diagnosis.

PMID- 1020401
TI  - [Experiences with sodium fluoride in the treatment of osteoporosis].
AB  - In 10 patients with primary and 13 patients with glucocorticoid osteoporosis a
      NaF-therapy with an average daily dose of 80 mg was carried out in a period of
      1/2 to 4 1/2 years. 22 patients spoke about an improvement of the complaints.
      Radiologically an osteogenesis could be proved in 19 patients. Dose and duration
      of the therapy as well as eventual additional treatments, frequency and severity
      of the side-effects are discussed and the indication for a NaF-medication are
      elaborated.

PMID- 1020402
TI  - [Comparability of jet and ultrasonic aerosols in bronchial reactivity tests].
AB  - The use of tests of bronchial reactivity for expert's opinions as well as ability
      examinations and check-ups in the field of occupational medicine makes great
      demands on their reproducibility. In the case of different application techniques
      the comparability of the test results is to be proved. For two aerosol producers
      used in the GDR test variants reliable for many years were comparatively
      investigated. Hereby the possibility could be proved on principle to achieve
      comparable results by variation of the concentration of the acetylcholine
      solution given. The choice of the test concentration in question is decisively
      influenced by the aim of the examination and the kind of test persons.

PMID- 1020403
TI  - [Primary hyperlipoproteinemia and cardiovascular diseases in relation to age].
AB  - The primary hyperlipoproteinaemia is a frequently appearing disease of the second
      half of life. Out of 188 patients with hyperliporpoteinaemia 19% were at an age
      of 40-49 years, 33% at an age of 50-59 years and 51% of 60-69 years. The type IV
      of hyperlipoproteinaemia was the most frequent one (19%), in the second place was
      type IIa (21%) and in the third place was type IIb (14%). In the 5th decade of
      life type IV prevailed in males and type IIa in females, in the 6th and 7th
      decade of life nearly the same percentage for these types was to be found in both
      sexes. In 60% of the patients with hyperlipoproteinaemia we found a hypertension,
      in males in 20% coronary insufficiency appeared already in the 4th decade of
      life, then it rose to 70%, in females these appearances occurred about 10 years
      later. 9% of the patients fell ill from myocardial infarction. A general
      arteriosclerosis appeared in 63% of the males and in 89% of the females beginning
      with the 5th decade of life, then it still increased. Therefore, adequate
      preventive and curative measures (diet and pharmaca) are necessary in time.

PMID- 1020404
TI  - [Unusual joint complications in sickle cell anemia].
AB  - It is reported on the casuistics of a 23-year-old Lebanese who since his eighth
      year suffered from joint swellings and occasional attacks of jaundice. By the
      proof of false forms of erythrocytes and by the haemoglobin electrophoresis a
      homozygous sickle cell disease could be ascertained. Peculiarities of the
      clinical picture were among others changes of the bones of high degree
      (osteolyses of vertebral bodies, of the head of the right humerus and the heads
      of the two femurs) was well as of the knee-joints in form of ankyloses.

PMID- 1020405
TI  - [Long-term results in electric pacemaker therapy].
AB  - It is reported on experiences and results in 317 patients with altogether 690
      implantations of pacemakers from 1963 to 1974 and under comparison and with
      reference to the up to now existing long-term results published in literature
      state and tendency of the medical and technical development of the electric heart
      stimulation are discussed. The average age of outpatients was 62.9 years with a
      peak of age of 46% in the 7th decade of life. 60% were male patients, 40% female
      ones. With about 50% the constant total atrioventricular block was the most
      frequent indication. 63% of the familiar types of pacemakers were biotronic
      apparatuses, 36% of them with fixed frequency. The average duration of the
      function of all apparatuses was calculated with 20.1 months. Hereby the biotronic
      types had the longest average function times of 26.7 months (frequency fixed) or
      26.3 months (regulated). In 373 reimplantations is shown that 2.17 apparatuses
      were implanted in each patient. The total number of complications was 21.2%
      related to the total number of implantations. With 8.9% breaks of the cable were
      in the first place in myocardial electrodes. Dislocations of transvenous
      electrodes were observed only in 4.5% of our cases. With 5.8% pressure necroses
      and infections were the cause of complications stood in the second place
      concerning frequency. The total lethality was 23.7% with an age peak of 38% in
      the 8th decade of life. 13.4% of the cases of death belong to an early lethality
      with a prevailing part of epicardial implantations. In our patients the
      cumulative survival rate was after 1 year 89.3%, after 5 years 62.3% and after 8
      years 47.7%. The 50% survival rate was ca. 7.3 years. In comparison to the
      population of the same age the average expectance of life is transgressed by
      about 6 years. The prolongation of the survival time by electrostimulation
      compared with the conservative treatment of the total atrioventricular block with
      Adams-Stokes-syndrome is the essential result of the pacemaker therapy.

PMID- 1020406
TI  - [Behavior of the plasma renin activity and aldosterone after salt restriction and
      upright posture in essential hypertension].
AB  - In 100 patients with essential hypertension and 50 healthy subjects the relation
      between plasma renin activity (PRA) and plasma aldosterone level (Ald) was
      investigated. PRA as well as plasma aldosterone was estimated a) after a diet
      with normal sodium content (equals 120 mEq per day) provided for 3 days and after
      an 8 hrs rest ("L" value of PRA and Ald) and b) after sodium restriction (10 mEq
      per day) for 3 days and 3-4 hrs ambulation ("A" value of PRA and Ald). Concerning
      the behaviour of "L"- und "A"-PRA all patients were divided into 4 groups: a)
      patients with normal, b) rigid, c) low and d) high PRA. Despite differentiated
      values of PRA in patients of all groups a normal increase of the plasma
      aldosterone level was stated after sodium restriction in the diet and upright
      position. Even in 18% of healthy subjects with low PRA a normal increase of Ald
      after sodium restriction and upright position was observed. These results seem to
      prove that in patients with low and rigid PRA and in 18% of healthy subjects the
      renin-angiotensin system is not the main or only regulator of aldosterone
      secretion.

PMID- 1020407
TI  - [Physiotherapeutic early mobilization of patients with myocardial infarct].
AB  - It is reported on the experiences of the programme of the physiotherapeutic
      treatment of the patients with myocardial infarction in the phase of
      hospitalisation, which was used in our clinic in 128 patients since 1972. Under
      careful control the period of mobilisation could be shortened without larger
      endangering for the patient and a new temporary step scheme could be given as
      guiding principle, the use of which, however, always needs the individual
      adaptation by physician and physiotherapist. The physiological and psycho-social
      advantages of an early mobilisation are clear.

PMID- 1020408
TI  - [The 131I-fibrinogen turnover during activation of blood fibrinolysis].
AB  - The influence of stanozolol Stromba and phenformin Dibotin (Winthrop) and
      complamin (Wulfing) on transformation of 131J-fibrinogen administered
      intravenously was examined in 39 patients with arteriosclerosis obliterans. The
      patients were divided into 3 groups; one of the groups included untreated
      patients. Radioactivity of the plasma and of the urine was determined by means of
      a scintillation counter. The volume of plasma, plasma fibrinogen (g%, g, g/kg),
      half time of persistance (T 1/2) and degradation of fibrinogen were determined.
      The patients who received Dibotin and Stromba simultaneously showed statistically
      significant decrease of the plasma fibrinogen degradation im comparison to the
      control group. But in patients who received complamin in spite of significant
      decrease of the plasma fibrinogen (g%), the fibrinogen degradation was not
      different from the value obtained in the group.

PMID- 1020409
TI  - [Contribution to the continuous indirect blood pressure measurement].
AB  - The plethysmanometer described follows the principle of the relaxed wall of the
      vessel. Here the pressure is adjusted in a finger cuff and by means of a
      pneumatic regulation is varied in such a way that the light plethysmogram of the
      adequate finger does not show any more pulsations. Thus the pressure effected on
      the finger above the cuff corresponds to the pressure in the finger arteries and
      is to be registered in mm Hg. When the course is measured in the same test person
      with changing of the arterial pressure (e.g. absolute arrhythmia or compressed
      air pressure experiment) the blood pressure of the aorta measured when a heart
      catheter is diagnostically indicated shows a very close correlation to the
      unbloodily registered pressure of the finger arteries. On the other hand, greater
      varieties of the correlation coefficient which can be proved from test person to
      test person at present do not yet allow a formula obligatory in general, in order
      to tansfer the value unbloodily measured into the adequate bloody one.
      Nevertheless, already nowadays great ranges of application are possible for the
      progressing measuring of the blood pressure.

PMID- 1020410
TI  - [Comparative analysis of electrocardiographic findings in diabetics and
      metabolically healthy persons].
AB  - The electrocardiograms of 447 diabetics and of the same number of non-diabetic
      test persons who were coordinated as biostatic twins, taking into consideration
      age, sex, and weight, were evaluated according to the Minnesota-code and
      compared. The cardiac endangering of the diabetics was most clearly expressed in
      the larger frequency of infarctions and the chronic-ischaemic heart disease which
      can be proved in all age groups. Diabetic males with short duration of diabetes
      showed the highest frequency of infarctions. The frequency of coronaropathy which
      is not increased in most age groups in the long-term diabetics compared with the
      control persons characterizes them as a positive selection of diabetics with an
      apparantly primarily low atherogenic potency. Hypertonus and/or adiposity were
      concomitant with a nearly doubled frequency of the ischaemic heart disease. The
      breadth of the P-wave as a possible reference to angiopathic changes in the
      region of the atrium was significantly larger in the diabetics in all age groups
      than in the control group.

PMID- 1020411
TI  - [Clinical ergometry in cardio-pulmonary functional disorders--a comparison of the
      usual ergometric technics].
AB  - It is reported on the results of a comparative examination of 18 patients with
      two usual ergometric methods (team pathophysiology of respiration and research
      group diseases of heart and circulation of the GDR). Referred to the intake of
      oxygen as a measure for the stress of the cardiorespiratory system by means of
      the ergometric methods recommended by the research group diseases of heart and
      circulation significantly higher minute volumes of the heart rate were
      established. Principal differences in the evidence of the two methods did not
      appear.

PMID- 1020412
TI  - [Lethal varicella in infants].
AB  - Varicella are regarded as relatively harmless disease. Since the application of
      antibiotics as complication appear rare mortal courses of generalised varicella
      above all as a sequel of haemorrhagic-gangrenous forms of course (especially
      under therapy of corticosteroids), of varicella pneumonia and of encephalitides,
      while the bacterial superinfection is in second place concerning exitus letalis.
      Two own observations of varicella infections having a fatal outcome in a 1 1/2
      year-old child and a 2-year-old child are reported. In the two cases the
      efflorescences of the skin were already healing. While one child suddenly died at
      home (concerning the cells a typical perivenous encephalitis as well as a
      varicella hepatitis without nuclear inclusion bodies was proved), the older child
      was admitted to hospital after sudden deterioration and abscess-formation of a
      chickenpox pustule. Clinically a meningo-encephalitis was established, which
      after dramatic course led to death still at the day of admission. As to the cells
      only slight perivenous round cell infiltrates could be proved in severe cerebral
      oedema, cytolyses and sporadic perivascular haemorrhages and emedullations.

PMID- 1020413
TI  - [Immune status in a case of thyroid gland sarcoidosis--selected parameters].
AB  - On the basis of a case of sarcoidosis and the thyroid gland selected
      immunological parameters were examined and they were compared with the findings
      in pulmonary sarcoidosis. While the examination of the immunoglobulins in the
      present case did not show any characteristic changes, in the examination of the
      cellular immunity the hyporeactivity of the peripheral lymphocytes typical for
      the pulmonary sarcoidosis was found. The inclusion of immunological parameters is
      an enlargement of the possibilities for the differential diagnostic clarification
      of granulomatous inflammations of the thyroid gland.

PMID- 1020414
TI  - [Isolated ultrafiltration with dialyzer and blood pump in hydropic cardiac
      insufficiency].
AB  - The authors indicate the possibility of an "Isolated Ultrafiltration" in
      cardiologic patients only with the transportable blood conducting part of the
      artificial kidney. The loss of oedema fluid by ultrafiltration of the blood is
      about 500 ml/h using a twin coil dialysator "Keradenta", or, resp., more than
      1,200 ml/h using a Hollow Fibre Artificial Kidney "Dow Cordis" Mod. 5 or two
      HFAKs Mod. 4 in parallel. The method should be practised only in such cardiologic
      patients, in whom a drug-resistent hyperhydration including hypervolaemia is not
      a sign of a sure terminal state.

PMID- 1020415
TI  - [The cerebrospinal fluid contact processes in the central canal of the spinal
      cord. A scanning and transmission electron microscopic study of the rabbit].
AB  - The surface of the central canal of the rabbit spinal cord was investigated with
      scanning and transmission-electron microscopy. On the ventral wall of the central
      canal, a long cranio-caudally oriented area carries a row of bulbs (about 630 per
      millimeter of length). The bulbs are spinal ventricular processes of
      cerebrospinal fluid contacting nerve cells. Its cytoplasm contains mitochondria,
      smooth- and rough-surfaced endoplasmic reticulum and vesicles of various size and
      contents. The bipolar or multipolar nerve cells are situated below the ependymal
      cells of the central canal. The perikaryon has the general cytological structure
      of a neuron. Some nerve fibres are shown to be running in the cranio-caudal
      direction within the central canal. Axons containing synaptic vesicles (diameter
      400 A) form synapses on some of the ventricular processes. Two main types of
      ventricular processes can be observed, they differ in the size and structure of
      the end bulb, in the shape of its sterocilia, and in the number of mitochondria.
      Big globular processes are filled with a great number of mitochondria, whereas
      stereocilia are lacking. On the contrary, small processes with numerous
      stereocilia extending radially into the cerebrospinal fluid contain a number of
      mitochondria. A third type takes the mid position between the two main types. The
      ventricular processes have no "sensory cilia". On the basis of these
      morphological differences the possible role of mitochondrial movements in the
      function of the ventricular processes and the question of the identity of the
      three types of processes are discussed.

PMID- 1020416
TI  - An opaque material apposed to the periphery of the subplasmalemmal Cisterns of
      cochlear outer hair cells.

PMID- 1020417
TI  - Seasonal variations in the histology of the pituitary gland of Cirrhinus mrigala
      (Ham.) an Indian freshwater major carp, in relation to gonadal activity.
AB  - 1. Seasonal variations in the histology of the pituitary gland of Cirrhinus
      mrigala (Ham.), an Indian freshwater major carp, in relation to gonadal activity
      has been studied during a one year period commencing, January, 1971. 2. The
      proximal pars distalis undergoes a great deal of seasonal variation in size,
      weight and nature of pituicytes. 3. The percentage composition of acidophils and
      cyanophils in the proximal pars distalis show a reciprocal relationship during
      the year. The acidophils predominate during the restitution phase of the gonads
      while the cyanophils preponderate among the different cell types during the
      breeding season. 4. The chromophobes do not show any significant fluctuation in
      numerical abundance in relation to gonadal activity. 5. Cyanophils of the
      proximal pars distalis undergo changes with change in gonadal activity
      Concentration of glycoproteinaceous material is extremely low during the
      restitution phase but high during the maturation phase. The cyanophils also
      undergo hypertrophy and hyperplasia during the spawning period. The latter
      discharge their contents and become vacuolated during the post spawning period.
      6. The number and size of the globules in the cyanophils are related to gonadal
      activity. 7. Acidophils present in the rostral pars distalis and pars intermedia
      do not appear to be related to gonadal activity in C. mrigala. 8. The average
      weight of the gland is directly related to the state of maturation of the gonads,
      an observation being recorded here for the first time.

PMID- 1020418
TI  - Neurohypophysial-adrenal gland responses to water-deprivation in the rose-ringed
      parakeet.
AB  - The aim of the present investigation is to study the relative influence of
      neuohypophysis, adrenal cortex and adrenal medulla under dehydration stress in
      the parakeet. Birds subjected to dehydration for 7 days lost body weight.
      Neurosecretory material (NSM) was partially depleted from the neurohypophysis.
      Adrenal gland weight was increased followed by a hypertrophy of the cortical
      tissue. A fall in adrenal cholesterol and ascorbic acid level was marked.
      Adrenaline and noradrenaline contents of the adrenal medulla were suppressed as
      was evident from cytochemical and biochemical findings. It is suggested that
      neurohypophysis, adrenal cortex and adrenal medulla are involved in maintaining
      water homeostasis in this avian species.

PMID- 1020419
TI  - Observations on the ultrastructure of secretory cells of bulbourethral glands
      under the influence of estrogen-releasing preparations.

PMID- 1020420
TI  - The escape of bile from the intrhepatic biliary tree in acute bile stasis.
AB  - The escape of fluorescent dyes from the bile passages during bile stasis and
      after a retrograde infusion into the common bile duct was examined in rats and
      mice. After an intravenous dye injection in bile stasis a strong fluorescence is
      seen in the periportal spaces. During retrograde dye infusion great amounts of
      dye accumulate in the periportal spaces but, in consequence of focal disruption
      of liver cell membranes, escapes also into the spaces of Disse, to be
      consequently transported by the sinusoidal blood.

PMID- 1020421
TI  - [Ultrastructure of the vocal muscle and its morphological differences from the
      myocardium].
AB  - A comparative ultrastructural investigation of the M. vocalis in mammals has been
      carried out. Morphological differences between the vocal muscle and cardiac
      tissue are reported; a distinct classification of the M. vocalis according to a
      typisation of skeletal muscle fibers is presented. In all species investigated
      (man, dog, cat, guinea-pig and rat) the general ultrastructure of the sarcomeres
      as well as their mitochondrial content and the innervation pattern allow to
      classify the M. vocalis as to belong to the "fast twitch (white) skeletal muscle
      fibers. A single innervation was found with large motor endplates containing
      numerous synaptic infoldings. Structural specializations known to be
      characteristic for cardiac tissue, e.g. intercalated discs, T-tubules at the
      level of the Z-band and nuclei in a midst postion of the muscle cell could not be
      observed. The m. vocalis, therefore, cannot be considered to have histologically
      any relationship with cardiac tissue. The vocal muscle is described as a special
      type of skeletal muscle very similar to the extraocular muscles. The electron
      microscopic findings are discussed with respect to current theories of phonation.
      The myoleastic theory of phonation can be favoured according to our
      ultrastructural results.

PMID- 1020422
TI  - Correlative cytological and histochemical studies on the avian oogenesis.
AB  - A correlative cytological and histochemical study has been made of oogenesis in
      birds (pigeon, Columbia livia; brown dove, Streptopelia senegalensis; ring dove,
      S. dacaocto; domestic fowl. Gallus domesticus; and quail, Coturnix coturnix).
      BALBIANI'S vitelline body consisting of large yolk nucleus, mitochondria, GOLGI
      bodies and lipid bodies of variable composition is gradually developed in the
      juxtanuclear cytoplasm of their young oocytes. Histochemical tests indicate that
      the yolk nucleus consists mainly of RNA, protein and lipoprotein. Mitochondria
      occur in the form of granules, rods and filaments having a phospholipid-protein
      composition. The lipid bodies are in the form of granules (composed of
      phospholipid and triglycerides) and spheres (made up of triglycerides and
      cholesterol and/or its esters). The organelles consisting of lipoprotein are
      preserved after classical techniques of cytology whereas the lipid bodies are
      mostly dissolved. With the growth of oocyte during previtello-genesis the various
      cell components of BALBIANI'S vitelline body are dispersed in the outer ooplasm
      where they further multiply and finally most of them are placed in the cortical
      layer. At the same time, many chromophilic and argentophilic elements of
      lipoprotein nature are formed in the follicular epithelium, adjacent to plasma
      membrane of oocyte and in the peripheral ooplasm during previtellogenesis, which
      gradually accumulate in the central ooplasm where the yolk vesicles first appear.
      Most of the lipid droplets consisting of triglycerides and cholesterol and/or its
      esters are depleted from the large previtellogenic oocytes. The possible
      significance of various ooplasmic structures, which accumulate during
      previtellogenesis, has been discussed. Corresponding to the development,
      multiplication and accumulation of various ooplasmic components during
      previtellogenesis the chromosomes develop the configuration of lampbrush and are
      the active sites for the synthesis of RNA and protein, which simultaneously
      accumulate in the ooplasm. The cytological and histochemical characteristics of
      follicle cells indicate that they are active in the secretion of lipids,
      glycogen, proteins and RNA which are apparently transported into the growing
      oocyte. The association of several lipid bodies with some phagocytotic vacuoles
      adjacent to the plasma membrane of growing previtellogenic oocyte has supported
      this suggestion. Several follicle cells as such degenerate during
      previtellogenesis and their products in the form of DNA, RNA, protein and
      lipoprotein also seem to be absorbed directly or indirectly by the growing
      oocyte. During early vitellogenesis, the yolk vesicles are formed in the central
      ooplasm by the activity of ooplasmic structures especially the chromophilic and
      argentophilic elements. They are ultimately transformed into yolk bodies of
      variable morphology and chemical composition, which are arrayed in alternating
      concentric spheres (yellow and white) and consist of proteinlipoprotein,
      triglycerides, carbohydrates, RNA etc...

PMID- 1020423
TI  - [Professional image of the state industrial-medicine physician].

PMID- 1020424
TI  - [Occupational diseases decree and its realization].

PMID- 1020425
TI  - [A new occupational disease].

PMID- 1020426
TI  - [Occupational hearing disorders due to noise].

PMID- 1020427
TI  - [Hepatitis as an occupational disease].

PMID- 1020428
TI  - [Damage due to dust].

PMID- 1020429
TI  - [Pneumoconiosis due to silica and asbestos dust].

PMID- 1020430
TI  - [Occupational diseases and the general practitioner].

PMID- 1020431
TI  - [Drug therapy of hyperlipemias].

PMID- 1020432
TI  - [Treatment of bronchitic diseases using Perspiran-juice].

PMID- 1020433
TI  - Surgical treatment of vascular lesions of the spinal cord.
AB  - Paravertebral block and resection of upper thoracic sympathetic ganglions were
      performed on cases in which vascular disturbance of the spinal cord was
      considered partly responsible. Block was performed in 14 cases and clinical
      improvement was seen in 10 cases out of them while resection was considered
      effective in 2 out of 3 cases. The evoked EMG of patients was assumed recovery of
      a part of synaptic function in the ischemic cord after the block. On the other
      hand, the skin temperature of the lower extremity did not show considerable
      change and this supports the view that the restoration of clinical picture was
      not due to the improvement of the periphral circulation of extremities. From
      these observations, it would be well presumed that favorable effect of
      sympathectomy consists partly in the improvement of vascular disturbance of the
      spinal cord.

PMID- 1020434
TI  - Popliteal artery entrapment syndrome.

PMID- 1020435
TI  - Production of experimental atrial septal defects.
AB  - Atrial septal defects (ASDs) were successfully created by punch biopsy technique
      in 67 dogs. The technique is simple, effective and provides an ideal model for
      the study of ASDs, either for testing closure devices or physiological
      experiments. The position and size of the defects may be varied according to
      preference. Of 45 animals subjected to cardiac catheterization, 39 (87 percent)
      has a patent atrial septal defect.

PMID- 1020436
TI  - [Role of gastrin in the genesis of disordered stomach secretory activity in liver
      cirrhosis].

PMID- 1020437
TI  - [Total energy debt as a measure of the reversibility of terminal states of the
      body].

PMID- 1020438
TI  - [Microcirculation and the level of toxicity in the dynamics of burn shock of
      varying severity in rats].

PMID- 1020439
TI  - [Level of lipid peroxide and antioxidant activity in ischemic and preserved
      kidneys].

PMID- 1020440
TI  - [Theoretical and practical bases of the search for psychotropic preparations].

PMID- 1020441
TI  - [Regulating the energy metabolism of the heart using physiologically active
      substances].

PMID- 1020442
TI  - [Search for central neurotropic drugs close to natural biologically active
      substances].

PMID- 1020443
TI  - [Physiological activity of natural derivatives of imidazole].

PMID- 1020444
TI  - [Physiologically active substances in general and local pathologic processes].

PMID- 1020445
TI  - [Role of physiologically active substances in the pathogenesis and therapy of
      atherosclerosis].

PMID- 1020446
TI  - [Eruthropoietin--the hormone of erythropoiesis].

PMID- 1020447
TI  - [Molecular interaction of hormones with enzymes].

PMID- 1020448
TI  - [Biosynthesis, metabolism and action of prostaglandins].

PMID- 1020449
TI  - [Principles for studying pharmacologic agents].

PMID- 1020450
TI  - [Enzymes and protein inhibitors in surgery].

PMID- 1020451
TI  - [Indicators of cellular immunity in various dermatoses].

PMID- 1020452
TI  - [Use of pyrogenic therapy in dermato-venereology].

PMID- 1020453
TI  - [Immediate results of treatment of syphilis with erythromycin simultaneously with
      bismuth preparations].

PMID- 1020454
TI  - [Acute syphilitic hepatitis in early syphilis].

PMID- 1020455
TI  - [Effect of microdoses of manganese chloride on the course of experimental
      allergic dermatitis].

PMID- 1020456
TI  - [Impetigo herpetiformis Hebra].

PMID- 1020457
TI  - [Case of lymphogranuloma venereum].

PMID- 1020458
TI  - [Urethro-oculo-synovial (Reiter's disease)].

PMID- 1020459
TI  - [Clinical course of gonorrhea in girls].

PMID- 1020460
TI  - [Gonorrheal abscess of the penis].

PMID- 1020461
TI  - [Early prevention of syphilis (experimental study)].

PMID- 1020462
TI  - [Treatment of contagious forms of syphilis by continuous complex method].

PMID- 1020463
TI  - [Effectiveness of artificial iodobromide waters in the treatment of active
      syphilis].

PMID- 1020464
TI  - [Histochemical characteristics of retinal neuron deoxyribonucleoprotein in
      different groups of invertebrates].

PMID- 1020465
TI  - [Sports and health].

PMID- 1020466
TI  - [Physician and sports].
AB  - The main objective of physical activity should be to achieve the best possible
      level of physical fitness and thereby psychic wellbeing. This important objective
      in preventive medicine may be obtained by a well balanced leisure sport program.
      On the other hand, due to its high demands, modern competition sport or elite
      sport increasingly results in severe organic damages and therefore therapeutic
      measures are of more importance. The physician has important functions both in
      prevention and therapy in all aspects of physical activity. Unfortunately, in
      Switzerland he is ofter insufficiantly prepared to deal with these functions.
      Most of the requirements for manipulation of performance that the physician is
      confronted with are questionable and not compatible with the medical ethics.

PMID- 1020467
TI  - [Sports and health, view-point of a sociologist].
AB  - The expression "health" covers a wide physical, psychic and social range. The
      phenomenon "sport", in its cultural form, has evolved historically and is
      constantly changing. In the today's sport movement, we can see differences in
      age, sex, and social status related to the type of sport practised, the frequency
      and the motivation as well as its form of organization. The main inducement for
      practising sport is by friends. At the end of the article, the author points out
      that it is problematic to misuse sport for pedagogic aims or aims of preventive
      medicine, because in such cases, sport runs the risk to lose its initial
      objective which, originally, had no definite goal other than the experience
      itself. Moreover, it is irrational to believe that sport alone can cure
      civilization diseases both in the physical as well as in the psychic and social
      range.

PMID- 1020468
TI  - [Physical activity and coronary heart disease prevention].
AB  - Numerous reports indicate that physical inactivity is one of the coronary risk
      factors; however, proof that exercise has a protective effect is still elusive.
      Nevertheless, to continue the existing controversy on the prophylactic value of
      physical activity seems to be inappropriate. On the one hand, a controlled trial
      is not feasible; on the other hand, physical activity is a physiological function
      that should be promoted anyway, regardless whether irrefutable evidence of its
      value in the prevention of coronary heart disease is available. Activity starting
      in childhood and continuing throughout life is a safe approach. In more general
      terms, habitual physical activity should be re-introduced into the pattern of
      life of contemporary society.

PMID- 1020469
TI  - [Sports in prevention of postural defects].
AB  - Posture results from numerous alternating factors and reflects the attitude of an
      individual towards a definite situation. If the different conditions, namely the
      capacity and the willingness of posture, do not correspond to the requirements of
      the situation the "normal" erect posture will change. The development from
      abnormal posture into irreversible abnormalities and damages in posture is easy.
      In order to eliminate these risks one can try to reduce the potential of the
      situation on the one hand and to improve the capacity of the individual through
      adequate physical exercise on the other. The practice of daily physical activity
      at school or during leisure time is the best way to compensate for lack of
      exercise, to modify prolonged unfavourable situations, and to develop the
      physical capacity in such a way that dangerous loads can be supported without
      damage. The versatility of training, in combination with adequate gymnastical
      exercises and sports help to educate the sense of posture and movement with the
      effect that erect posture can be adopted and maintained. But only children who
      feel that erect posture is reflecting their personal image will finally keep the
      erect posture. Special attention is given to elite training in childhood and
      adolescence, when the vertebral column is particularly exposed to danger by the
      intensity of the training and must be protected against deformations by carefully
      chosen preventive measures.

PMID- 1020470
TI  - [Sociological aspects of sports activities in adolescents].
AB  - The purpose of this study was to investigate the epidemiological, psychosocial
      and sociological aspects influencing the practice of physical activity of young
      people. Of approximately 1800 17 to 18 years old boys and girls going to an
      official school in Geneva, 600 were chosen at random. Unskilled workers could not
      be included into the study. 443 subjects could be contacted and interviewed in
      spring 1973 through a codified questionnaire. A first evaluation of the answers
      focused on the influences of sex, social status, type of sport practised, as well
      as the ideological integration. The results correlated well with current empiric
      experiences or with most of the hypothesis on which the questionnaire was based.

PMID- 1020471
TI  - [Sports activities and motivation].
AB  - In a representative study on employees aged 20 to 65 years in Northern
      Switzerland, several criteria of sports practice and motivation to practise
      sports were examined. 1260 subjects working in 44 different factories employing
      more than 56 people were chosen at random and questioned. 36% of the younger men
      (20 to 42 years old) and 21% of the older ones (43 to 65 years old) were members
      of a sports club. The first motivation to participate in sports came mostly from
      friends, but hardly ever from international events. 21% of the subjects were in
      favour of the way the Olympic Games were conducted, 28% were somewhat critical,
      41% were negative, and 10% had no opinion.

PMID- 1020472
TI  - [State and sports].
AB  - By 1874 the State had already started to influence physical activity programs
      especially of the younger generations in Switzerland. In 1970 the people accepted
      article 27 of the Constitution regarding physical education and sports. The
      Federal law that became effective in 1972 now promotes, in a more intensive way,
      physical education and sports as a means to improve the public health. These
      measures especially affect public sport (physical education at school, the "Youth
      and Sports" organization, the construction of sports facilities) whereas
      promotion of elite sports is entirely the responsibility of the independent
      sports association. Today, this promotion costs the Swiss government roughly 40
      millions of Swiss francs, or 0.3% of the whole budget.

PMID- 1020473
TI  - [Exercise test in coronary insufficiency diagnosis].
AB  - If the anamnesis is not conclusive for a definite diagnosis of angina pectoris or
      if a complementary test is adviseable the ECG, which is hardly ever significant
      at rest, can become very significant under the influence of physical activity.
      The easiest methodology is a bicycle ergometer or a treadmill performance test
      which can be performed under ideal safety conditions and which gives the best
      possible information. Compared to the coronarography results in 319 patients, the
      performance test at either maximum heart rate or up to the appearance of the
      typical electrocardiographic alterations was positive in 75.5% of the cases. It
      is less instructive if the test is not systematically exhaustive. Its validity
      also varies depending on the number of coronary arteries affected by stenosis, on
      the type of the angina pectoris, and the aspect of the ECG at rest. If the test
      is performed up to the maximum heart rate, its sensitivity is superior to the
      ones using lsoprenaline or right atrial pacing as a means for influencing the
      ventricular function.

PMID- 1020474
TI  - [Medical fitness for sports, with particular reference to cardiovascular
      conditions].
AB  - Whether a person is medically fit to engage in sports depends not only on his or
      her present state of health but also on his or her previous medical history, age,
      personality, and of course, the nature of the particular sport in question.
      Anyone that feels fit, is physically in good condition, abstains from tobacco,
      alcohol and other intoxicant stimulants, and passes a thorough medical
      examination is healthy and fully capable of taking part in any sport whatever.
      Participation in any form of sport, on the other hand, is absolutely contra
      indicated for persons suffering from severe or malignant hypertension,
      inflammatory or bacterial heart disease, severe angina pectoris - especially with
      an attendant risk of myocardial infarction - or haemodynamically significant
      arrhythmias that manifest themselves during, or are aggravated by, physical
      exertion. Physical activity is generally deleterious in patients with advanced
      pulmonary disease and chronic cor pulmonale, severe decompensated heart failure
      or severe renal insufficiency. Severe intercurrent infections also constitute an
      absolute contra-indication for sport. Between these two extremes of absolute
      fitness and absolute unfitness there are many intermediate states, e.g. diseases
      like essential hypertension (WHO Stages I and II), coronary disease and
      peripheral arterial circulatory disorders, in which patients can derive
      considerable benefit from properly chosen and carefully graded sporting activity.

PMID- 1020475
TI  - [Sports accidents: 1963-1973 statistics].
AB  - Every year, the Swiss Accident Insurance Administration is paying a considerable
      amount of money for sports accidents. From 1963 to 1973 the number of these
      accidents has increased more markedly than other types of accidents. Different
      tendencies can be observed in the different types of sports: skiing accidents
      have, after a long period of retrogression until 1973, shown a noticeable
      augmentation again. Football accidents and accidents in other types of sports
      have on the other hand increased year by year. Mountaineering and aquatic sports
      often result in fatal accidents. The numerous preventive measures in skiing
      accidents have obviously been successful. Not only the fractures have decreased,
      but also the average number of days where sickness benefit was paid. Next to the
      traffic accidents, the skiing accidents are the most expensive ones. The nature
      of the healing cost in sports accidents has changed during the period from 1967
      to 1972, depending on the different types of sports. In particular, hospital
      costs have changed considerably. The number of medical consultations per accident
      has decreased. Payment of sickness benefit has followed the development of the
      salaries on the one hand and the modifications of the number of lost days on the
      other. Finally, the costs of the annuities show more or less the same tendency as
      the ones for sickness benefit. A very gross estimation on the economical losses
      through sports accidents in Switzerland makes us believe that the direct and
      indirect costs actually amount to more than one thousand millions of Swiss Francs
      per year.

PMID- 1020476
TI  - [Health risks of various sports].
AB  - Sport accidents have become a major problem. When investigating the risks
      corresponding to different sport activities, we must consider incidence, possible
      causes and different kinds of sport injuries too. The risks of sport injuries are
      not inherent to a given sport, but are more likely provoked by the athlete
      himself and his behaviour.

PMID- 1020477
TI  - [Elite sports - benefit or damage].
AB  - Out of 378 elite athletes investigated in the year 1956, 28 track and field
      athletes, 14 footballers, 9 cyclists and 18 icehockey-players, who were
      complaining about serious injuries at the occasion of a sociological
      investigation, underwent a medical follow-up examination, 30 percent of the
      examined athletes stated that they suffered from permanent pain as a result of
      their former career in elite sports. On the other hand, they had a positive
      attitude about their previous physical activity and would not have missed it at
      all. Most of the injuries concerned joints (61) or bones (18) whereas other
      localisations were rather unusual. X-ray examination revealed a considerable
      number of orthrosis which most of the time, in spite of its sometimes rather
      grotesque appearance, did not cause the expectes subjective complaints.

PMID- 1020478
TI  - Total red and white blood cell count of 33 species of fresh water teleosts.

PMID- 1020479
TI  - [Nutritional-physiological problems with the trace element chromium in the rat.
      5. Influence of total metabolic output].

PMID- 1020480
TI  - Cesium metabolism in sheep and the influence of orally ingested bentonite on
      cesium absorption and metabolism.

PMID- 1020481
TI  - [Partial utilization of food energy by the fatted calf].

PMID- 1020482
TI  - Crude fibre as an index for predicting the digestibility of protein in expeller
      processed oilseed cakes for poultry.

PMID- 1020483
TI  - [Significance of venous invasion in renal parenchymal tumor for prognosis].

PMID- 1020484
TI  - [Operative treatment of vesico-ureteral refluxes in children and adults].

PMID- 1020485
TI  - [Blunt abdominal injury and the differential diagnosis in regard to associated
      injury of the urogenital tract].

PMID- 1020486
TI  - [Comparative histological examination after conventional nephrotomy and
      electronephrotomy].

PMID- 1020487
TI  - [Model of a subject specific hygiene regulation for urology in the hospital and
      ambulance].

PMID- 1020488
TI  - [Foreign body in the ureter].

PMID- 1020489
TI  - [Leiomyoma of the urinary bladder].

PMID- 1020490
TI  - [Diet in chronic renal insufficiency].

PMID- 1020491
TI  - [Clinical picture and differential diagnosis of renal pelvis tumors].

PMID- 1020492
TI  - [Comparison of therapeutic results in testicular tumors with respect to co
      management of the retroperitoneum].

PMID- 1020493
TI  - [Prostate malacoplakia].

PMID- 1020494
TI  - [Variations in the etiology and therapy of gynecologic-urologic fistulas treated
      in our clinic].

PMID- 1020495
TI  - [Perfusion methods and contrast media elimination in angiographic studies during
      initial hypothermic kidney perfusion in experimental animals].

PMID- 1020496
TI  - [An unusual case of urinary pseudocyst].

PMID- 1020497
TI  - [Dynamics of primary disability].

PMID- 1020498
TI  - [Study of the general morbidity of alcoholics among the urban population].

PMID- 1020499
TI  - [25th Congress of the CPSU and some problems of the further development of public
      health].

PMID- 1020500
TI  - [Occupational traumatism in mining personnel taking into account social and
      domestic factors].

PMID- 1020501
TI  - [Compliance with the recommendations of district therapists in the dispensary
      treatment of hypertension].

PMID- 1020502
TI  - [Some problems of managing public health today].

PMID- 1020503
TI  - [Blood coagulation in newborns (author's transl)].
AB  - This article gives a survey of the physiology of blood coagulation in newborn
      infants, subdivided into the particularities of the plasmic coagulation system
      and the fibronolysis. Etiology, diagnosis and therapy of the consumption
      coagulopathy as well as the coagulopathy of production are dealed with.

PMID- 1020504
TI  - [Bioptical diagnostics of hirschsprung disease by the membrane technique for the
      histochemical demonstration of cholinesterases (author's transl)].
AB  - 50 biopsies of the rectum and 8 of the large intestine from male and female
      children aged 4 months to 7 years, obtained by resection were investigated. The
      absence of ganglion cells in the intrinsic nerve plexuses is in agreement with
      the increased cholinesterases reaction. The presence of muscularis mucosae is
      necessary in the biopsy for the evaluation of the cholinesterase reaction. The
      instrument used for the excision must fulfill those demands.

PMID- 1020505
TI  - [Conservative treatment of infantile supracondylar fractures of the humerus
      (author's transl)].
AB  - 58 infantile supracondylar fractures were treated conservatively. Due to
      accompanying lesions in 2 cases osteosynthesis was performed by using crossed
      extension wires. According to Morger's evaluation scheme conservative treatment
      yielded good results in 49 cases, satisfying results in 4 cases and sufficient
      ones in 5 cases.

PMID- 1020506
TI  - [Diagnosis and treatment of a rare intrapulmonary vascular anomaly in a child
      (author's transl)].
AB  - In the present case an artery originating from the abdominal aorta and running
      through the diaphragma into the inferior lobe of the left lung was identified by
      retrograde aortography. It ended in a vascular coil which was drained by regular
      pulmonary veins. By transthoracal resection of pulmonary parenchyma and
      malformation was removed without complications. Such anomalies represent absolute
      but not urgent indications for surgery. Without treatment, the shunt volume will
      cause additional straining for the heart. Furthermore, pulmonary complications
      and thromboembolic processes may arise.

PMID- 1020507
TI  - [Invalidation of a girl after 7 years of succesfull malingering of a wound
      (author's transl)].
AB  - Provocation of wounds by malingering is one of the most typical artefacts in
      surgery. In this paper the succesful maintaining of a wound in a girl for over 7
      years is demonstrated. In this time the girl underwent 25 surgical operations and
      was invalidated at the age of 18 years. In patients with non-healing wounds,
      which cannot be explained by the rules of general pathology, doctors are well
      advised to think of the possibilities of malingering at an early time.

PMID- 1020508
TI  - [Diaphragmatic paresis as a birth trauma in a newborn infant].

PMID- 1020509
TI  - [Sixfold invagination in a child].

PMID- 1020510
TI  - [Stomach trichobezoar].

PMID- 1020511
TI  - [Comparative colposcopic, cytological and histological studies of the uterine
      cervix during pregnancy].
AB  - The suspected findings, of colposcopic and cytologic cervix uteri in the
      pregravidity, was reported. Among 5852 patients, who primarily were directed in
      the clinic for interruption, 63 of them were examined because of their suspected
      colposcopic results and 3 cases of them were examined because of their suspected
      cytologic results, at the same time a detailed histological clarifications of
      their portio during the interruption were made. About 30,8% of the cases were in
      preinvasive or invasive stages, which were histologically clarified and
      precarcinogenic treatment of the patients was carried out. On the evidence of the
      results, we recommend, that by all suspected colposcopic cases -- taken into
      consideration of the cytologic results -- an early histologic clarification be
      made.

PMID- 1020512
TI  - [Total estrogen level in umbilical cord blood during physiological labor].
AB  - The levels of total oestrogens in umbilical vein and artery and in maternal
      peripheral blood were investigated in 24 normal labours. The levels in the
      umbilical artery were significantly lower than in the vein. This difference was
      connected with the level of oestrogens in umbilical vein, but not with the foetal
      weight. No correlation between the oestrogens levels in the umbilical and
      maternal blood was found.

PMID- 1020513
TI  - [Ultrastructural studies on the permeability of the amnion-epithelium for
      peroxidase and ferritin. Contribution on paraplacental metabolism].
AB  - By means tracer substances (horseradish peroxidase, ferritin) the permeability of
      human amnion and umbilical cord (2. to 6. lunar month) has been investigated
      ultrastructurally. The structure of intercellular cleft permits a passiv transfer
      of the water and electrolytes in both ways. The findings indicated, that the
      passage of proteins with a molecular weight of peroxidase predominantly takes
      place through the intercellular clefts less by means of pinocytosis. Ferritin
      particles can not penetrate. The epithelium of umbilical cord seems to play no
      special role in protein and water transport. The results were discussed.

PMID- 1020514
TI  - [Influence of labor induction using Prostin F2alpha on the cardiovascular system
      of the fetus].
AB  - Conform to its reaction, prostin F2alpha is a useful medicament above all in
      order to initiate risky deliveries having a state of unripe cervix. We have
      estimated the labor pains and the fetal state, which did not give proofs for any
      negative influence by prostin F2alpha in 60 initiations of labor. An intensive
      supervision system is absolutely necessary.

PMID- 1020515
TI  - [The problem of rifampicin therapy in pregnancy].
AB  - Report on a 24 years old first pregnant woman with chronic pyelonephritis,
      treated for 1 1/2 years, also during pregnancy, with high doses of rifampicin
      (1200 mgs/day). After normal delivery in the 42 th. week of pregnancy there were
      bleedings both in mother and newborn with demonstrable temporary disturbances in
      liver-function and coagulation system. Especially the coagulation factors
      produced in the liver were concerned. The complications after rifampicin carried
      out the conclusion that rifampicin should be given in pregnancy only with exact
      indication.

PMID- 1020516
TI  - [Clinical and x-ray studies on the relationship between interruption of pregnancy
      and premature labor].
AB  - On the basis of the number of premature babies of 1975 the possible
      interdependence is checked between interruptio of pregnancy and subsequent
      premature birth and is compared with the dates obtained in 1974. Besides the
      hysterograms of women with premature birth whose anamnesis indicates an
      interruptio of pregnancy, are examined with regard to lesions of the cervix
      demonstrable in roentgenograms. As in the years of 1974 and 1975 the number of
      premature birth has been approximatively constant we conclude, basing ourselves
      on the investigations of roentgenograms, that no causal relation may be
      established between interruptio of pregnancy and premature birth in our material.

PMID- 1020517
TI  - [The significance of continuous fetal monitoring for further lowering of
      perinatal morbidity. Pilot study].
AB  - By means of a pilot study we tried to calculate the perinatal morbidity after
      continuous fetal monitoring. From 810 electronical and biochemical monitored high
      risk babies in the period from 1971 to 1973 we checked and/or have investigated
      685 risk-newborns. Thereby 87 (=12,7%) were premature newborns. From this 685
      risk-newborns 14 (=2,04%) appeared conspicuous. Only by 7 of them (=1,02%) we
      found mental and/or physical retardation. 2 of this children have a cerebral
      palsy. Causes of retardation with and without cerebral palsy we could lead back
      in the perinatal period. The causes are discussed. We point to the urgency of
      comprehensive follow-up studies.

PMID- 1020518
TI  - [Psychological aspects following continuous fetal monitoring].
AB  - 100 women were examined in labor upon the so-called intensive birth room. In this
      connection we discovered, that the prevailing number of women to be in labor had
      a positive position to the surrounding modern implements for the continuous fetal
      monitoring. Explanation and a corresponding preparation to birth by means of
      consultations and psychopropylactic methods cut a great figure. Education,
      profession and social position were factors, influencing the answers in the same
      form how the position from the mother to the present pregnancy.

PMID- 1020519
TI  - [The apgar value of the newborn and its prognostic value for the course of the
      neonatal period].
AB  - The prognostic value of the postnatal Apgar-score to the course of the neonatal
      period. It is impossible to determine exactly vital functions of the infant
      postnatal sole with a number. However we are the opinion, that Apgar-score is
      valid for the first clinical classification of the neonate. We studied 6780
      newborn from 6 large towns of the GDR. Two thirds of the cases were selected with
      risk. The Apgar-score from 1 minute postnatal was correlated to findings of
      clinical investigation, diagnostic and therapy during the neonatal period from 2
      hours postnatal to 8 days. Interesting correlations are found between the Apgar
      score from 1 minute postnatal to: color of the skin (pale or pink), cyanosis,
      type of respiration, stridor, posture, crying, X-ray findings of the lung, need
      of buffer and oxygen therapy and neonatal death. Summarizing we found
      correlations of clinical value between the postnatal Apgar-score and the later
      respiratory function.

PMID- 1020520
TI  - [The value of radioimmunological HPL determinations for the evaluation of
      intrauterine fetal growth during late pregnancy].
AB  - In 24 high-risk pregnancies correlation between maternal level of HPL in serum
      and the weight of the newborn is examinated. Retarded fetal growth was assumed of
      the weight of the newborn was found below the 5. percentil. Results of
      statistical sensitivity and specificity of radiommunoassay of HPL are given for
      this question.

PMID- 1020521
TI  - [Total protein and immunoglobulin content of human milk].
AB  - The content of total protein and immunoglobulins in the breast-milk has been
      determined by the biuret-method and radial immunodiffusion. The immunoglobulins
      IgG, IgA and IgM has been ascertained in all samples. The concentrations of total
      protein and of immunoglobulins are higher in the colostrum but in the breast
      milk.

PMID- 1020522
TI  - [Immunoglobulin content of the cervix mucosa in early pregnancy].
AB  - The immunglobulins IgA, IgG and IgM in the extracts of homogenised cervical
      tissue from pregnant women were measured with the help of radial immunodiffusion
      of Mancini et al. The values of IgA and IgG increased during investigation. The
      low concentrations of IgM could not be evaluated quantitatively.

PMID- 1020523
TI  - [Longitudinal study of the blood protein concentration during normal pregnancy,
      at the time of delivery and on the 7th post-partum day].
AB  - The concentration of serum protein was determined in 227 women during the 11th to
      13th, 24th to 26th and 33rd to 35th week of pregnancy as well as immediately
      after delivery and on the 7th day post partum according to the Biuret method. A
      small but significant decrease of protein was observed during the second
      trimester of pregnancy (Ist Trimester x(-) = 7,57; IInd Trimester x(-) = 7,26
      g/100 ml). The lowest values was found immediately after delivery (x(-) = 6,86).
      The mean concentration on the 7th day post partum was increased again (x(-) =
      7,37). The values were compared with there of 190 non-pregnant women (x(-) =
      7,57).

PMID- 1020524
TI  - [Histochemical studies of the secretory capability of myometrial cells during
      pregnancy].
AB  - Investigations of many authors carried out on animals have shown the ability of
      myometrium cells to synthesize and secrete proteins and glycoproteid products in
      the period of pregnancy. The author's own studies have been carried out on human
      and animal material. In the muscles slices of gravid uterus as markers of
      appropriate cytoplasmatic structures were found out: S-nucleotidase, TPP-ase,
      succinat dehydrogenase, acid phopshatase and additionally glycogen. On the basis
      of the results obtained it may be concluded that in myometrium cells of gravid
      uterus morphological features of Golgi Apparatus (bacilliform, crescent,
      vesicular and granular structures) and mitochondria as well as the amount of
      glycogen manifest metabolic activity of these cells. Considering heterogenity of
      morphological forms of Golgi Apparatus and frequent charateristic polar
      localization round the nucleus it may be supposed that the cells charakterized by
      these features may possess the ability of secreting synthesized proteins or other
      products.

PMID- 1020525
TI  - [Lymphogranulomatosis and pregnancy].
AB  - Four cases in lymphogranulomatosis and pregnancy are presented and compared to
      the opinions of other authors. Though a lot of questions are unknown yet, it
      seems that pregnancy doesn't have an unfavourable weight with
      lymphogranulomatosis.

PMID- 1020526
TI  - [A very large luteoma gravidarum].
AB  - A case of luteoma gravidarum detected during cesarean section is reported for the
      first time in German literature. The tumor described is the biggest of its kind
      so far. By means of this own observation details of origin, clinical behavior,
      histology and therapy of this odd tumor are discussed. Nevertheless a good deal
      remains enigmatical and further studies will be as interesting as actual.

PMID- 1020532
TI  - [Positive and negative ions influence on the activity of the adrenal cortex
      (author's transl)].
AB  - The cortisol level in the serum of mice, which had been exposed to the influence
      of negatively or positively ionized air for 30 minutes, was determined by means
      of competitive protein fixation. Under the influence of both ion moieties, the
      cortisol level rose to twice the physiological norm (p less than 0,001 in both
      cases). - Theoretically the inhaled air ions might exert influence on the
      regulatory cycle hypothalamus - hypophysis - ACTH - adrenal cortex both
      neurogenically and directly via the circulatory system, thereby changing the
      cortisol level. For this reason, the determination of ACTH, as well as of
      cortisol after hypophysis exstirpation, must be regarded as a prerequisite for
      further investigations.

PMID- 1020533
TI  - [Biochemical and psychological examinations of trichloroenthylene exposed
      volunteers (author's transl)].
AB  - Seven healthy volunteers were exposed to approximately 100 ppm (=520 mg/m3)
      trichloroethylene for six hours daily during a period of five consecutive days. A
      corresponding group was exposed a placebo in the same manner. -Biochemical and
      psychological examinations were accomplished in the beginning and the end of each
      day respectively the whole period. Thereby the intraindividual as well as the
      interindividual loads were taken to judge the health impairment. - For this
      purpose trichloroethylene, trichloroethanol and trichloracetic acid were
      determined in blood, as well as total trichloroethanol and trichloroacetic acid
      in urine. For the measurement of the biochemical parameters gaschromatography is
      considered the best method. The combination of the "intern standard" with the
      synchronous determination of the metabolites of trichloroethylene is described as
      a new treatment. These time-efficient and practicable procedures are the most
      important suppositions for "biological monitoring". Results are confirmed as far
      as known in literature as well as the course of trichloroethylene in blood is
      described for the first time. The modern methods of psychology applied to tests
      and standardized questionaires served to quantify the intellectual and
      psychological conditions of the solvent exposed volunteers and of their
      corresponding group. The group results were compared. Thereby no significative
      differences were visible. Altogother the results show that during the 5 days
      exposition to 100 ppm (=520 mg/m3) trichloroethylene no impairments of the
      examined persons' mental and psychological capacities could be determined in
      spite of the biochemically quantified incorporation of the solvent.

PMID- 1020534
TI  - Clearance of benzo(a)pyrene from the respiratory tract of hamsters following its
      intratracheal instillation with or without ferric oxide.
AB  - A comparative study was carried out on the clearance of benzo(a)pyrene (BP) from
      the respiratory tract of Syrian golden hamsters following intratracheal
      instillation of either BP alone or BP attached to ferric oxide particles. Eight
      series of 18 hamsters each, received a single intratracheal instillation of 0.5
      or 1.0 mg BP suspended in 0.9% NaCl solution. In addition, three comparable
      series of hamsters received in the same way a mixture, of 1.0 mg BP + 1.0 mg
      ferric oxide suspended in 0.9% NaCl solution. In each of the series the BP
      content of the respiratory tract was determined at six different points of time
      viz. immediately after administration of BP or BP + ferric oxide, and three, six
      and 24 hours, and three and seven days after an instillation. The clearance of BP
      from the respiratory tract did not appear to be significantly influenced by the
      presence of ferric oxide. It was concluded that the present study produced no
      evidence of ferric oxide particles being capable of enhancing the retention of BP
      in the respiratory tract.

PMID- 1020535
TI  - Repeated exposure to cyclopentenone vapour: long-term study in Syrian golden
      hamsters.
AB  - Effects of cyclopentenone inhalation were examined in a 78-week study with 420
      hamsters evenly distributed over two inhalation chambers, one for exposure to air
      and the other for exposure to the test substance. Cyclopentenone was dosed at a
      level of 18 ppm (seven hr/day, five days/week) during the first 52 weeks, and at
      a level of 27 ppm during the last 26 weeks of the study. During the first 52
      weeks, part of the animals in both chambers fortnightly received an intratracheal
      instillation  of benzo(a)pyrene (BP) or diethylnitrosamine (DENA) in saline or
      saline alone. Exposure to cyclopentenone caused slight growth depression in both
      sexes, and slightly increased relative liver weights and enhanced development of
      renal amyloidosis in females only. There was no evidence of cyclopentenonne
      possessing carcinogenic activity or being a co-factor in respiratory tract
      carcinogenesis.

PMID- 1020536
TI  - [Air and water contamination by road abrasion (author's transl)].
AB  - Owing to the abrasion of tar-containing or bituminous road surfaces particles are
      liberated which contain carcinophilic poly-aromatic hydrocarbons e.g. 3.4
      benzpyrenes (BP). The effects of abrasion were determined by comparative
      measurements alongside a highway section of tar asphalt and one of concrete, both
      subjected to an identical traffic load. Airborne dust, sedimented dust near the
      ground and the degree of sewage pollution were measured. The wearing layer of the
      tar-asphalt surface consisted of TA16: max. grain size 16 mm; bonding agent TB
      2000(containing  13 per cent tar pitch and 87 per cent bitumen). With a mean
      traffic load of 9000 vehicles per day abrasion liberated 15 mg 3.4-benzpyrene per
      month in winter and in summer 10 mg 3.4-benzpyrene per month and per 1 meter
      length of a two-laned highway. It was found that in the coarser dust particles
      the abrasion material containing 3.4-benzpyrene prevails. As a result, the tar
      asphalt abrasion in precipitated dust contained more than 50 per cent of total
      benzpyrene, while its share amounted even to 70 per cent of the total load in the
      floating fraction of waste water.

PMID- 1020537
TI  - [Experiments to study paper for its suitability as sterile wrapping (author's
      transl)].
AB  - A description is given of experiments for the testing of germ density of paper
      intended for use as sterile wrapping. The generally used storage tests are
      unsatisfactory. The following procedure is proposed for the testing: The paper
      specimen is cut into pieces of about 7 X 7 cm and steam-sterilized at 134 degrees
      C. A number of samples is placed on the bottom of Petri dishes and each paper
      sample is sprinkled with 5 drops of a 0.1 ml suspension of Staph. aureus in
      distilled water. After drying, the paper samples are placed underside down on the
      surface of a blood agar plate so as to ensure complete contact. After about 5
      seconds the paper samples are removed and the plates are incubated for 16 hours
      at 37 degrees C.

PMID- 1020538
TI  - [On the incidence of Staphylococcus aureus in the throat of medical students
      (author's transl)].
AB  - There have been taken throat swabs of 148 medical students for making inquiries
      about the carrier rate of Staph. aureus. 106 of these persons could be checked-up
      after ca. two weeks. A comparison was made with the nursing staff of surgical
      wards of a university hospital. In view of the medical students Staph. aureus
      could be cultivated out of the throat swabs in 30%, in view of the hospital staff
      in 22%. 18% of the medical students were carriers for least two weeks. The Staph.
      aureus strains isolated from medical students and those isolated from the nursing
      staff showed on principle the same characteristics towards antibiotics
      resistance. With regard to the bedside-teaching it should be taken into
      consideration, that medical students are carriers of Staph. aureus to such a
      degree as the nursing staff.

PMID- 1020539
TI  - [Possible error in interpretation of liquor enzyme activities as demonstrated on
      the example of lactate dehydrogenase and cholinesterase].
AB  - If examinations of the liquor are to give an insight into the metabolic condition
      of the brain, then it is necessary for all sources of error to be removed. The
      use fo exact methods requires that the liquor be free of major pleocytosis. In
      vitro examinations showed that additions of blood caused the activity of LDH to
      be doubled within thirty minutes, while that of cholinesterase even increased
      sixfold. It is especially after craniocerebral injuries that extra care must be
      taken to insure that the liquor used is as clear as water.

PMID- 1020540
TI  - [Problem of the angiographic demonstration of subdural empyema in the
      interhemispheric cleft].
AB  - List's falx syndrome is confirmed on the basis of an analysis of six own patients
      and of a survey of the literature on 16 cases of interhemispheric empyemas. The
      angiographic diagnosis of interhemispheric empyemas is uncertain, and this is in
      contrast to opinions expressed in the literature. Negative angiographic results
      cannot be considered to rule out the possibility of the presence of an empyema in
      the interhemispheric space. In those cases in which corresponding clinical
      evidence is available it is recommended to always surgically explore the
      interhemispheric space subsequent to broad trephination.

PMID- 1020541
TI  - [Complications of the operative neurosurgical treatment of trigeminal neuralgia].
AB  - The complications after neurosurgical treatment of trigeminal neuralgia of 161
      patients treated in the neurosurgical hospital university medical school Bonn
      from 1971 to 1974 are referred. Emphasis is layed on severe complications. After
      rhizotomia (Dandys method) 3 patients died, one of them because of a meningitis,
      one of them because of damage of the superior petrosal vein and one after
      ligature of an irregular auditive artery. One patient died after
      electrocoagulation of the ganglion Gasseri (Kirschner's method) after having had
      an important bleeding during coagulation. Another patient developed hemiparesis
      after a strong arterial bleeding during electrocoagulation. The damage of
      importance arterial vessels seems to be decisive. Three proposals in order to
      diminish the risk of the operations are settled: 1. Preoperative
      neuroradiological checks by means of contrast. 2. Carefully sparing of vessels,
      especially when precedent scars had alterated the field of operation, perhaps if
      necessary by means of the operation mikroscope. 3. Control of the lokalisation of
      the needle during electrocoagulation by X-rays.

PMID- 1020542
TI  - A standardized model of microembolization in the cat brain.
AB  - A standardized method is described for the experimental reproduction of micro
      embolism in the cat brain with obstruction of the cortical capillaries and
      following "remote" effects in the white matter. The model is useful for
      reproducing the phenomena observed in human fat embolism. Further results will be
      published in a future paper.

PMID- 1020543
TI  - [A case of pyocele in the sphenoid bone cavity].
AB  - A case is reported where the clinical symptomatology as well as the
      ophthalmological, radiological, endocrinological, and scintigraphic results
      offered significant evidence in favor of the presence of a tumor in the sellar
      region. The diagnosis of a pyocele originating in the sphenoid bone could be
      established intraoperatively only. Cysts originating in the sphenoid bone are
      described as what is usually called an "orbital inlet syndrome" from which the
      present case differs in some respects.

PMID- 1020544
TI  - [Myxopapillary ependymoma of the os sacrum].
AB  - A sacro-presacral myxopapillary ependymoma with a long anamnesis is described. A
      total of 46 other cases have heretofore been reported in the literature, which
      were systematized in this paper from a clinical as well as developmental point of
      view. Surgical interventions performed in the early and later phases of the
      disease resulted in restoration to health and subjective alleviation,
      respectively.

PMID- 1020545
TI  - [Value of ophthamoneurologic diagnosis in cranio-cerebral injuries of the child].
AB  - In recent years, there has been a relatively high incidence of craniocerebral
      traumas among children. It is essential that careful ophthalmological
      examinations be made in addition to a general diagnosis, which should preferably
      be established by surgical means, as well as neurological and roentgenological
      examinations. The most important criteria of examination are the determination of
      the absence of external injuries to the eyes, the assessment of the mobility of
      the eyeball, tests of pupillary reactions, and an evaluation of the eyeground.
      The results of reexaminations made on 108 children, who had been receiving in
      patient treatment, one to five years ago, because of craniocerebral traumas of
      different degrees of severity, underscore the importance of ophthalmological
      diagnosis in this particular group of diseases.

PMID- 1020546
TI  - [Studies on surgical preparations for the concentration of radionuclides in brain
      tumors].
AB  - A total of 69 surgical preparations were used to determine the tumor-brain
      quotients of a number of radiopharmaceuticals and compare them with data reported
      in the literature of which the majority were externally measured values. The
      increases in activity of the tumor were on average, 2.5 times (131-J-HSA), 2.9
      times (99m-Tc-pertechnate), and 3-5 times (197-Hg-Neohydrin) higher than those of
      the brain tissue. The lowest tumor-brain quotients were obtained for astrocytomas
      regardless of the radiopharmaceutical used, while high values were found for
      meningiomas, glioblastomas, and some of the spongioblastomas. In 44 cases tumor
      brain quotients could be compared with scintigraphic results of which 36 were
      positive. Tumors having values less than 1-5 could not be scintigraphed. In the
      case of a negative scintigram of the brain the size and location relative to the
      base of the skull played a significant role although the tumor-brain quotient was
      high.

PMID- 1020547
TI  - [Morpho-physiologic evolution and biochemical evolution].

PMID- 1020548
TI  - [Several genetic and evolutionary aspects of the problem of environmental
      pollution with mutagens].

PMID- 1020549
TI  - [Interrelationship between immunologic and neurologic memory: learning ability of
      rats during immunostimulation].
AB  - Studies have been made on the effect of an immunostimulator - the complete
      Freund's adjuvant - upon the learning ability in Wistar rats for visual
      discrimination using food-obtaining and avoidance of the electric shock
      techniques. Injection of the adjuvant significantly increases learning ability
      provided negative reinforcement technique is used, but inhibits the former under
      the conditions of positive reinforcement. Analysis of the extinction of the
      conditioned reflexes yielded similar results. Possible relation of immunogenesis
      to the formation of memory is discussed.

PMID- 1020550
TI  - [Patterns in the binding of cytotoxic neuropharmacologic preparations by early
      sea urchin embryos].
AB  - Early embryos of Arbacia lixula, Paracentrotus lividus and Sphaerechinus
      granularis intensively bind cytotoxic neuropharmacological drugs, such as
      antiserotonine indole derivatives, cholinolytics and tricyclic antidepressants.
      The binding intensity decreases markedly upon quaternization of the drugs.
      Quantitative analysis indicates that: a)with respect to the drugs, the suspension
      of living embryos may be described as a single adsorbing system following the
      Langmuir equation; b) at least two independent binding pools exist in embryos; c)
      the magnitude of cytotoxic effect of a given drug is not proportional to its
      binding.

PMID- 1020551
TI  - [Lactate dehydrogenase isoenzymes in the eye, cardiac and skeletal muscles of
      several decapods].
AB  - Properties of lactate dehydrogenase (LDH) in the eye, heart and muscles of
      Hemigrapsus sanguineus, Paralithodes camtschatica, Erimacrus isenbeckii, Pandalus
      latirastrus, Pagurus brachiomastus have been studied with acrylamide gel
      electrophoresis and kinetics analysis. LDH in all the tissues of all the
      representatives studied was found to be specific for L-pyruvate and lactate; it
      migrated in electrophoresis as a single band revealing low mobility towards
      anode. The isoenzyme from P. camtschatica and P. latirastrus differed from the
      isoenzymes of other animals studied by higher mobility towards anode that
      reflected higher negative value of its total charge. The LDH isoenzymes in all
      the animals studied resembled the A4 (LDH5) of the vertebrates being unstable to
      the denaturing action of high temperature and being unaffected by high
      concentrations of pyruvate up to 1.0.10-3M. On the other hand, in conrast to the
      A4 of mammals, the LDH in question displayed enhancement of the reaction rate and
      decrease of the Km values upon increase in the NAD+ and NAD.H concentrations both
      in the presence of high or low lactate and pyruvate concentrations. The
      isoenzymes displayed catalytic activity also in the presence of NADP, the Km
      values for pyruvate in the presence of equimolar (2.25 mM) concentrations of
      NAD.H or NADP.H were practically identical and were found to be within the limits
      of 14-26.10-5 M. Molecular weight of the LDH studied assessed by the gel
      filtration method was found to be 130-140,000. It is suggested that the LDH
      isoenzyme from the representatives of the decapod crayfish studied is homologous
      in its certain properties to the homotetrameric A4 form of the vertebrates.

PMID- 1020552
TI  - [Carbon dioxide fixation in aquatic animals and its metabolic significance].
AB  - In experiments on the carp Cyprinus carpio and freshwater lamellibranch mollusc
      Anodonta cygnea, tissue and organ peculiarities of carboxylic reactions have been
      revealed together with their relationship to the temperatute and ionic
      composition of the incubation medium. It was shown that in fish the highest
      intensity of fixation of CO2 is exhibited by glandular organs with biosynthetic
      profile of the metabolism (liver), whereas in molluscs it is exhibited in the
      mantle which plays the key role in the formation of the shell, containing
      carbonate compounds of calcium.

PMID- 1020553
TI  - [Variability in several ecologic-physiologic traits of different populations of
      the Asiatic Arctic suslik Citellus parryi].
AB  - In several geographic populations of the Arctic ground squirrel C. parryi,
      studies have been made on changes in oxygen consumption during decrease of the
      ambient temperature from 25 to 3-4 degrees, thermal preference, hemoglobin
      content of the blood and composition of the adipose tissue (both brown and white,
      subcutaneous and visceral). Significant shifts of these indices were found. In
      animals from various parts of the species area, different sensitivity to cooling
      was found, as indicated by determinations of oxygen consumption at different
      temperatures and the prefered temperature: different hemoglobin content of the
      blood was also found together with differences in the level of two unsaturated
      fatty acids - the oleic and linoleic ones. Comparison of these data with similar
      results obtained on various populations of the Siberian ground squirrel C.
      undulatus revealed obvious differences between these close species with respect
      to the indices studied.

PMID- 1020554
TI  - [Wing receptors of the American cockroach Periplaneta americana].
AB  - Wing receptors of the cockroach have been studied using staining technique with
      methylene blue in living animals. Five types of the receptors were found:
      trychoid hairs, bristles, complaniform sensillae, chordotonal organs and
      multiterminal neurons. The majority of the receptors is located at the lower
      surface of the wing, especially along its ribs. Together with primitive features
      in the structure (polyneuronal origin of hairs and bristles, poor content of
      chordotonal organs, absence of distinct groups of companiform sensillae), some
      specialization of wing receptors with respect to flight function is noted
      (concentration of proprioceptors along the main mechanical axis of the wing and
      formation of distinct rows by the companiform sensillae).

PMID- 1020555
TI  - [Pathways for the transmission of visual information in the protocerebrum of the
      drone fly Eristalis tenax].
AB  - Studies have been made on the structure of neuropiles and visual pathoways in the
      brain of the fly E. tenax L. (Diptera, Syrphidae). The retina is projected on
      laminar structures in the visual ganglia only; other protocerebrum neuropiles
      lack this projection. All the comissures connecting contralateral visual ganglia,
      consist of several hundreds of fibers, whereas the binocular zone of both eyes
      includes more than 4,000 ommatidia. Neither the visual ganglia, nor other
      protocerebrum neuropiles may serve as a substrate for topographic imposition of
      projections of the corresponding parts in both retines. The mechanism of
      binocular interaction in insects presumably differs from that in mammals
      (primates, carnovores).

PMID- 1020556
TI  - [Properties of neurons of the tectal portion of the visual system of the axolotl
      Ambystoma mexicanum].
AB  - In the tectum opticum of the adult neotenic A. mexicanum, responses of single
      neuronal units to diffuse illumination and moving visual stimuli have been
      investigated. Of 111 unites investigated, 27 are presented by tectal neurons,
      their maximum distribution being observed at a depth of 500-600 mu. In
      superficial layers 9 ipsi-elements were found; their receptive fields are located
      in the antero-dorsal part of the visual field, at both sides of the body axis.
      Among the units identified as the terminals of visual fibers, 70% have receptive
      fields of 5-10 degrees, being localized in general more close to the surface as
      compared to the units with the receptive field diameter of 40 and more degrees
      (11%). Visual neurons and ganglionic retinal cells with axons terminating in the
      tectum, exhibit poor specificity to the size of a stimulus within 5-30 degrees
      and do not react to stimuli of 2 degrees.

PMID- 1020557
TI  - [Visual projections in the forebrain of the carp Cyprinus carpio].
AB  - In the carp C. carpio, studies have been made on the evoked potentials (EP) in
      the-forebrain elicited by electrical stimulation of contralateral (with respect
      to the midbrain tectum) nerve. The most high-amplitude and short-latency EP were
      recorded in the rostro-lateral part of the forebrain at the depth of 1,000-1,500
      mu. According to the topographical nomenclature of cyprinid telencephalon, this
      region corresponds to the area dorsalis telencephali pars lateralis, whereas
      according to classic comparative neuroanatomical nomenclature it may be defined
      as the primordium hippocamp or primordium piriform zone. Comparison of the EP in
      the telencephalon with those in the midbrain tectum suggests active nature of the
      former.

PMID- 1020558
TI  - [Morpho-functional characteristics of the optic nerve of the steppe turtle
      Agrionemys horsfieldi].
AB  - The optic nerve of the tortoise Agrionemys horsfieldi contains about 400,000
      fibers (90% unmyelinated and 10% myelinated ones). the diameter of unmyelinated
      fibers varies from 0.3 to 1.1 mu, mean value being equal to 0.5 mu; fibers with a
      diameter 0.4-0.7 comprise 77%. The diameter of myelinated fibers varies within
      0.3-3.0 mu, average value being 0.5-0.8 nu; fibers with a diameter 0.5-0.9 mu
      amount to 62%. Electrogram of the optic nerve consists of two components which
      are equal in their amplitudes. These components presumably reflect summary
      firings of modal groups of unmyelinated and myelinated fibers. The velocity of
      propagation of excitation along the fibers producing the first component is equal
      to 1.3 m/sec, wheras that in fibers producing the second component - to 0.5
      m/sec. The data obtained are compared with those related for the other tortoise -
      Emys orbicularis.

PMID- 1020559
TI  - [Distribution of reticulospinal fibers and theri endings in the lumbar segments
      of the rat spinal cord].
AB  - After stereotaxis lexions in the nucleus reticularis gigantocellularis of the
      modulla oblongata and nucleus reticularis pontis caudalis, the distribution of
      degenerating nerve fibers in the lumbar segments of the spinal cord has been
      studied by silver impregnation methods of Nauta and Fink-Heimer. Degenerating
      reticulo-spinal fibers and fragments of axonal terminations were found in the
      area of n. motorius ventro-medialis and n. motorius ventro-lateralis, as well as
      partly in n. motorius dorso-lateralis close to motoneurons and their dendrites.
      Mainly they pass into layers VII and VIII. This fact indicates the existence of
      direct-reticulo-motoneuronal synaptic connections in rats, which coincides with
      electrophysiological data.

PMID- 1020560
TI  - [Hypotonic regulation in marine cladocerans Evadne nordmanni and Podon
      leuckarti].
AB  - At a salinity of the environment of 23-25% (delta degrees being equal to -1.28
      divided by-1.39), the depression of hemolymph in E. nordmanni is equal to -0.76
      +/- -0.11 degree, in P. leuckarti - to -0.75+/- -0.06 degree. This high level of
      hypotony persists up to the formation of the head-shild, after which the
      depression of marsupium fluid becomes equal to that of the external medium. It is
      suggested that the head-shield is involved into osmoregulation. Similarity of the
      level of the osmotic pressure of the internal medium in marine cladocerans and
      marine teleosts which also originated from fresh-water ancestors is noted.

PMID- 1020561
TI  - [Reflex movements of the dactylopodite in the claw of Astacus leptodactylus
      performed by structures of the isolated first thoracic ganglion].

PMID- 1020562
TI  - [Characteristics of afferent impulsation in response to acoustic signals at
      different levels of the auditory pathway in rats].

PMID- 1020563
TI  - [Coupling of enzymes to modified styrene-maleic anhydride copolymers].
AB  - A copolymer of styrene and maleic anhydride is modified with low molecular weight
      polyoles in a very convenient manner, so that it can be applied as a carried for
      the fixation of biologically active compounds without further pretreatment. The
      modified products show storage stability over a long time without loss of
      coupling capacity. Examples for the fixation of trypsin, alkaline phosphatase and
      a bacterial glutamate dehydrogenase are given, and some properties of the
      resulting enzyme products are described.

PMID- 1020564
TI  - [Influence of vagotomy on glucose tolerance and on the responses of plasma
      insulin and exocrine pancreatic function followed glucose load or food ingestion
      in dogs].
AB  - A part of the intrapancreatic nerve fibres of dogs show 1-2 months after
      bilateral truncal vagotomy a decay of the medullary sheath; in addition, the
      histochemically demonstrable insulin content of the B-cells is reduced. These
      animals do no longer react to oral glucose administration or feeding a meat meal
      with a reflectoric early rise of plasma insulin concentration and of exocrine
      functional parameters (all the animals were bearing exocrine pancreas fistulas).
      The glucose tolerance and and the decrease of free fatty acids in serum were
      restricted. Also, the content of bicarbonate and protein in the pancreatic juice
      and the insulin secretion of vagotomized animals are strongly reduced in the
      subsequent test phase (up to 120 min) following oral or i.v. glucose
      administration and after feeding meat. The inhibition of exocrine volume
      secretion following i.v. glucose administration was enhanced by the intervention.
      The findings confirm the involvement of the N. vagus in the mechanisms of the
      enteroinsular axis that becomes active together with exocrine gastro- and
      duodenopancreatic reflexes to any kind of physiological enteral stimulation.

PMID- 1020565
TI  - The mechanism of insulin secretion after oral glucose administration. VII.
      Exocrine pancreatic function and plasma-IRI in dogs with chronic pancreatic
      fistulas.
AB  - During an intravenous glucose test, conscious dogs with exocrine pancreatic
      fistulas showed a reduction in the secretions of water, protein and of
      bicarbonate. This reduction is related to hyperglycemia and to IRI increase in
      the peripheral venous blood. After oral administration of glucose, however, a
      biphasic stimulation of the exocrine function was observed. During the first 15
      minutes when insulin secretion increases independently of the blood glucose
      increase, all exocrine pancreatic functions are transiently stimulated, too. A
      second peak of the exocrine secretions is to be observed when glucose absorption
      and insulin secretion exhibit their maximum.

PMID- 1020566
TI  - [Reactivity of isolated arteries from hypertensive rabbits].
AB  - Isolated vessels (aorta thoracica, a pulmonalis, a. femoralis, a. renalis) of
      neurogenous-interoceptive and nephrogenous hypertensive rabbits showed a changed
      sensitivity to several vasoactive agents. An increased reactivity to
      noradrenaline, histamine, and serotonin in the aorta of neurogenous hypertensive
      rabbits, in the a. pulmonalis of neurogenous and renal hypertensive rabbits and
      in the a. femoralis of renal hypertensive animals in comparison with controls
      could be shown. Also registered was a hyperactivity to BaCl2 and KCl. All vessels
      of hypertensive rabbits were hyporeactive to angiotensin. They increased vascular
      reactivity was seen already in the 3rd week after removal of one kideny and
      pressoric receptors respectively. It is supposed that a "true supersensitivity"
      of the vascular smooth muscle cells of the hypertensive arteries does exist.

PMID- 1020567
TI  - [Influence of spasmolytic agents on the cumulative calcium dose-effect curve in
      isolation-perfused peripheral vascular beds].
AB  - The influence of verapamil, theophylline, and papaverine on the cumulative
      calcium dose-effect curve was studied at the isolated perfused rat tail. The
      results indicate different changes of the contraction and relexation phase
      respectively. The findings are discussed in connection with the action mechanism
      of the drugs and the processes of excitation-contraction coupling.

PMID- 1020568
TI  - [Extent and duration of drug-induced stimulation of renal excretion of p
      aminohippuric acid].
AB  - Repeated pretreatment with p-aminohippuric acid (PAH), probenecide,
      cyclopenthiazide, and phenobarbital stimulates the renal excretion of PAH. For an
      interval of at least 6 hrs following i.p. application pretreated rats excrete
      more PAH excretion than the controls. All the drugs studied were found to
      stimulate renal PAH excretion within a period of 3 hrs by 50-60% of the control
      value. The required duration of pretreatment varies with the substance used. With
      cyclopenthiazide, the excretion of PAH is demonstrable for 2-3 weeks.
      Phenobarbital has a brief stimulating action. Correlations of a binding of drugs
      to structures of their tubular cell and the length of the stimulating action are
      discussed.

PMID- 1020569
TI  - [Binding and distribution of chlordiazepoxide (Radepur) and its metabolites in
      the erythrocyte-plasma and erythrocyte-buffer systems].
AB  - The distribution and the free concentration of chlorodiazepoxide, desmethyl
      chlorodiazeoxide and demoxepam in the systems erythrocyte-plasma and erythrocyte
      buffer is determined. In both systems the substances are bound by erythrocytes. A
      constant ratio of distribution between erythyrocyte-plasma and erythrocyte
      buffer, respectively, is established beyond therapeutic concentrations. The
      association constants (dual reciprocal plot) of these substances are of the order
      of 10(4)-1-M-1. They are the same for erythrocytes and plasma. The specific
      binding of erythrocytes is 20-35 fold less than with plasma proteins. It is
      concluded that the erythrocytes are a binding intravascular subcompartment for
      chlorodiazepoxide and its metabolites.

PMID- 1020570
TI  - [Temperature dependence of the sedimentation velocity of human erythrocytes].
AB  - The sedimentation velocity of yeast cells and human erythrocytes as a function of
      temperature was studied in a range from 6 degrees C to 40 degrees C. Whereas this
      function for yeast cells can be described by an exponential function the
      measurements with erythorcytes show minima at 10 degrees C and 20 degrees C,
      respectively, and maxima at 13 degrees C and 38 degrees C. Changes of the density
      or the shape of the cells cannot be the reason for these effects. Viscosity
      measurements on erythrocyte suspensions as a function of temperature also show
      deviations from the exponential function between 18 degrees C and 24 degrees C.
      The results explain that alterations of the membrane viscosity and phase
      transitions of the membrane lipids influence the sedimentation velocity of
      erythrocytes.

PMID- 1020571
TI  - [Influence of inserted additional stimulation on the sensomotoric reaction time
      in relation to the interstimulus interval].

PMID- 1020572
TI  - [Inulin-clearance in the stimulation of renal excretion of p-aminohippuric acid
      through drugs].

PMID- 1020573
TI  - Blood group H like activity in crude preparations of bovine lung galactan.
AB  - In crude preparations of bovine lung galactan blood group H-like activity, which
      does not occur on bovine red cells, has been detected with  heterophile anti-H
      like reagents from different origin. These H-like receptors, associated with
      pneumococcus type XIV cross-reactivity, belong to a glycoprotein fraction and not
      to the galactan itself.

PMID- 1020574
TI  - Pacemaker treatment of patients over 80 years of age.

PMID- 1020575
TI  - [Tumors of the thoracic wall].

PMID- 1020576
TI  - [Partial pericardiectomy for pericardial tamponade in patients with chronic
      uremia under dialysis].
AB  - Two dialyzed uraemic patients were subjected to partial pericardiectomy because
      of haemorrhagic pericarditis and pericardial tamponade. Seventeen and nine
      months, respectively, after the operation the patients have still been under
      intermittent home haemodialysis.

PMID- 1020577
TI  - Effect of truncal vagotomy on the bacterial flora in the duodenal juice on dogs.
AB  - The qualitative and quantitative changes in the bacterial flora of the duodenal
      juice after truncal vagotomy have been studied in self-control experiments in
      dogs. The intervention was followed by a rise in the bacterial count without a
      change in qualitative composition. It is suggested that the accumulation of
      microorganisms might contribute to the development of postoperative diarrhoea.
      The role of several partly clarified pathophysiological processes are pointed
      out.

PMID- 1020578
TI  - [Transurethral resection of bladder neoplasms].
AB  - The technique of removal of bladder tumours is discussed on the basis of
      experience with transurethral resection performed on 200 patients suffering from
      bladder tumour (113 benign and 87 malignant tumours). The indications for the
      intervention are as follows. With benign tumours, resection has to be given
      preference over exposure. When malignant tumours are operable and situated on the
      mobile part of the bladder, radical surgery is recommended. When the tumour is in
      some other position, transurethral resection is the procedure of choice.

PMID- 1020579
TI  - [Hydatid cyst of the lung (author's transl)].
AB  - The authors, in an international collaborative study, report on 257 cases of
      operated hydatid cysts. The delicate choice between resection and conservative
      treatment depends on a protocole and/or on experience: in the large series
      published in the last 10 years the rate of resections has varied between 43 and
      less than 20 per cent. Cure of the pulmonary hydatid cyst, be it live or
      ruptured, is presently a well systemized, efficient and safe operation. The
      authors present their data that correlate well the sparse literature related to
      the subject in the last decade.

PMID- 1020580
TI  - [Reappraisal of the problem of hair transplantation (author's transl)].
AB  - Free transplants of hair-bearing scalp as "plugs" or "strips" are an adequate
      treatment for male alopecia. Cooling the grafts eliminates hematoma and infection
      and allows successful take and growth of larger plugs. However the result of
      grafting wide hairstrips is unreliable.

PMID- 1020581
TI  - [Acute cholecystitis without stones (author's transl)].
AB  - The authors report on ten cases of cholecystites without stones. Two were typhic
      in origin, six apparently primitive, one postoperative and one posttraumatic.
      They stress the importance of histologic lesions in each of these etiologies and
      insist on the high frequency of gangrenous forms in postoperative and
      posttraumatic cases. Previous antibiotherapy deserves no credit. Emergency
      cholecystectomy remains the best treatment.

PMID- 1020582
TI  - Role of calcitonin in the Zollinger-Ellison syndrome combined with
      hyperparathyroidism. Report of one case.

PMID- 1020583
TI  - [Hemorrhagic pseudocyst of the spleen (author's transl)].

PMID- 1020584
TI  - [Ruptured aneurysm of the inferior pancreatic-duodenal artery (author's transl)].
AB  - The authors stress the insidious onset of the lesion, which first presented as a
      hepatic or a gallbladder disease. Diagnosis was established later by an
      arteriography after the occurrence of a state of shock. Evacuation of the
      hematoma surrounding the aneurysm appeared satisfactory to re-establish the
      circulation; this was confirmed by an arteriogram. A review of the literature
      reveales 18 such cases, with a high mortality rate, up to 100% where surgery was
      not performed.

PMID- 1020585
TI  - [Blunt abdominal trauma. Advantages of the peritoneal lavage (author's transl)].
AB  - Among 80 cases of blunt abdominal trauma operated on at the University Hospital
      of Baviere during the last two years, peritoneal lavage has been performed in 40
      cases. In 39 cases, the diagnosis of blunt abdominal trauma has been established
      by the peritoneal lavage. A case of false negative result has been due to a
      technical fault. Peritoneal lavage must be considered as a very useful procedure
      for the diagnosis of hemoperitoneum and visceral lesions from blunt abdominal
      trauma.

PMID- 1020586
TI  - [Late sequellae of a splenectomy (author's transl)].
AB  - This is the case of a patient who underwent splenectomy after traumatic rupture
      of the spleen. After the operation, while on parenteral feeding, the patient
      presented with fever and septicemia during approximately 2 months; no origin to
      this could be found. Two months after the accident the patient died of
      perforation of a subdiaphragmatic abscess into the stomach and the lung. The
      authors discuss the possibilities of coming to an earlier diagnosis. They
      recognize the necessity of a more aggressive attitude to establish the diagnosis.

PMID- 1020587
TI  - Concentration of thyroxine, tri-iodothyronine and thyroglobulin in the thyroid
      lymph.
AB  - Human thyroid lymphatic fluid was collected from 8 patients operated upon for
      thyroid tumours. All tumours were of small size and localized to one lobe. The
      lymph was collected from the side opposite the tumour. The levels of thyroxine
      and tri-iodothyronine in the lymph were determined by a radioimmunoassay
      technique in 7 of the patients. The thyroglobulin content of thyroidal lymph from
      one patient was analysed. The results demonstrate higher levels of thyroxine and
      tri-iodothyronine in the human thyroid lymphatic fluid as compared with those
      seen in peripheral or thyroid venous blood. Evidence for the presence of
      thyroglobulin in the human thyroid lymphatic fluid was obtained.

PMID- 1020588
TI  - Indications for surgery in the elderly patient with primary hyperparathyroidism.
AB  - The major symptoms presented by the elderly patient with primary
      hyperparathyroidism (HPT) were studied in 30 patients, all of whom were over 70
      years of age (70-89). Neuromuscular symptoms, fatigue or mental symptoms were the
      main complaint in 14 patients. Nephrolithiasis, pancreatitis, skeletal changes or
      thyroid diseases were associated with HPT in 13 patients. Three patients were
      considered to be asymptomatic. Seven out of the eight patients with neuromuscular
      symptoms, and two of the three patients with extreme fatigue as the dominant
      symptom, improved postoperatively. This study indicates that for elderly patients
      with HPT especially when associated with neuromuscular symptoms or fatigue,
      surgical therapy is the treatment of choice.

PMID- 1020589
TI  - Bilateral fibromuscular hyperplasia in the internal carotid arteries with
      aneurysm formation.
AB  - A patient with bilateral fibromuscular hyperplasia in the carotid arteries with
      development of aneurysms is reported. The patient had no symptoms except for a
      palpable mass on one side and a bruit on both sides. Surgery was carried out
      bilaterally, using direct end-to-end suture on one side and a reconstruction with
      an autologous vein on the other side. It is suggested that fibromuscular
      hyperplasia may be the cause of some of the internal carotid artery aneurysms
      reported as congenital or with uncertain etiology. Reconstructive surgery of the
      carotid artery is recommended due to the obvious hazards of the condition.

PMID- 1020590
TI  - The phlebographic pattern of acute leg thrombosis within a defined urban
      population.
AB  - The incidence of thrombosis during one year in a defined population of 263 144
      city inhabitants has been studied with a new method based upon acute phlebography
      of all patients with the slightest symptoms of the disease. The roentgenographic
      pattern of the acute thrombosis has been studied and the size of the individual
      thrombus has been compared with the duration of the symptoms. The incidence of
      thrombosis was found to be 0.9 per mille per year. No correlation was found
      between the size of the thrombus and the duration of the symptoms. The thrombus
      had its origin in the calf veins in 89% of the patients and its origin in a vein
      at a higher level in 10% of the patients. In patients with a thrombus confined to
      the calf veins the contrast medium always entered the deep crural veins. When the
      calf vein thrombosis had an extension to the popliteal vein or still higher up
      the contrast medium bypassed the deep crural veins in more than 75% of the
      patients.

PMID- 1020591
TI  - Liver blood flow measurement the interpretation of xenon133 clearance curves.
AB  - Liver tissue perfusion can be measured by analysis of the clearance of the
      radioactive inert gases Xenon133 and Krypton85 from the liver. The technique
      commonly gives rise to multiexponential clearance curves which have previously
      been quoted as evidence of complex intrahepatic blood flow patterns. The
      clearance of 133Xe from the canine liver was studied in 17 dogs and by screening
      out extrahepatic radioactivity it was found that the true intrahepatic clearance
      is monoexponential. The slower components seen in the multiexponential curve
      recorded without screening represent 133Xe in tissue other than the liver and
      much of this activity was shown to originate from 133Xe which accumulates in the
      stomach and intestines. These findings simplify the interpretation of inert gas
      clearance curves in the measurement of liver blood flow and therefore encourage
      further application of the technique in both experimental and clinical
      situations.

PMID- 1020592
TI  - Enzyme histochemistry studies of transverse and longitudinal incisions in the
      common bile duct in rabbits.
AB  - The healing process of longitudinal and transverse incisions of the common bile
      duct in rabbits was studied by identification of 10 different enzymes in the duct
      wall at various times after the operation. Bile was deviated during the healing.
      An almost complete disappearance of the subepithelial alkaline phosphatase
      activity was noted early after longitudinal incisions in contrast to unchanged
      alkaline phosphatase activity after transverse incisions. Transversely incised
      ducts almost uniformly developed stricutre formation. The size of the lumen after
      longitudinal incisions was generally normal. The difference in enzyme pattern
      following the two types of lesion might reflect a different response of the
      tissues to the two different types of trauma.

PMID- 1020593
TI  - 170 patients five years after selective gastric vagotomy--with an uncontrolled
      comparison of ulcer recurrence following either Heineke--Mikulicz or Finney
      pyloroplasty.
AB  - The study concerns 170 patients treated for duodenal ulcer by selective gastric
      vagotomy and either HM- or FP. A 5-year follow-up showed a 4% recurrence rate.
      Insulintest 2-3 months after surgery was Hollander negative in 78%, late positive
      in 17% and early positive in 5%. 72% of the tests were unchanged after 5 years.
      25% had moderate severe dumping. In the HM-group of 84 patients, 6 patients
      displayed ulcer recurrence. In the F-group of 86 patients, one displayed
      recurrence. All patients with recurrence (and one without) in the HM-group had
      operatively demonstrated pyloroplasty stenosis. None of the patients in the F
      group had clinical symptoms of gastric stasis. The only variable in the treatment
      of the patients was the pyloroplasty method, and it thus seems reasonable to
      implicate the pyloroplasty method in the incidence of recurrence. The difference
      in recurrence between the two groups was not, however, statistically significant,
      and the value of a prospective randomized study of patients treated by selective
      gastric vagotomy and different pyloroplasty forms is pointed out.

PMID- 1020594
TI  - A comparison of small intestinal transit time between the rat and the guinea-pig.
AB  - The small intestinal transit was compared in rats and guinea-pigs. A radioactive
      test substance (polyvinylpyrrolidone labelled with I125) was given directly into
      the duodenum and the distribution of the isotope in the small bowel was recorded.
      The small intestine was removed 10 and 20 min after the injection and deep
      frozen. The frozen intestine was later cut in 20 segments of equal length and the
      amount of isotope within each of the intestinal segments was recorded by means of
      a gamma counter. For each animal a propulsion diagram was constructed showing the
      relative percentage of isotope distributed in the 20 bowel segments. After 20 min
      the isotope peak was found in the ileo-caecal region in the guinea-pigs whereas
      50% of the isotope had passed only half of the small intestine in the rats during
      the same period of time. The length of the intestine in rats passed by 75%, 50%
      and 25% of the isotope after 20 min was the same as that found in guinea-pigs 10
      min after the injection of the isotope into the duodenum. Thus, there seems to be
      a marked difference in propulsive activity between rats and guinea-pigs.

PMID- 1020595
TI  - Aneurysm of the pancreaticoduodenal artery. A case report.
AB  - A case of an aneurysm of the pancreaticoduodenal artery is reported, together
      with a short review of the literature relating to this condition  Because of its
      rarity the diagnosis is often overlooked even when typical changes are found on X
      ray. The possible relationship between obstructive jaundice and aneurysms in the
      vicinity of the galltree is discussed. Surgical treatment is recommended by most
      authors once the diagnosis of an intra-abdominal aneurysm has been made, mainly
      because of the risk of rupture.

PMID- 1020596
TI  - Prolonged recovery after extended right hepatic lobectomy in a patient with
      severe blunt liver injury and laceration of the vena cava. A report of case with
      special references to autotransfusion and complications of biliary decompression.
AB  - A patient with severe blunt liver injury and laceration of the vena cava who
      underwent a successful extended right hepatic lobectomy is reported. The use of
      autotransfusion unit saved the patient from exsanguination. His postoperative
      course was complicated by renal and hepatic failure, bile leakage, and persistent
      jaundice due to cholangitis. Prolonged choledochal drainage via T-tube obviously
      acted as a source of infection. The use of autotransfusion, choledochal drainage
      and the proper timing of its removal, the treatment of vena cava lesions and
      jaundice due to cholangitis in patients with severe liver trauma are discussed.

PMID- 1020597
TI  - [Advance of science and defense of research].

PMID- 1020598
TI  - Protein synthesis by synaptosomes from the head ganglion of the squid, Loligo
      pealli.

PMID- 1020599
TI  - Chronic allergic encephalomyelitis of the guinea pig: effects of maternal
      sensitization on the offspring.

PMID- 1020600
TI  - Mobility variation as a criterion of antitrypanosomal activity in vitro and
      potentiation of antimonials by serum.

PMID- 1020601
TI  - [Karyotype diversity and systematics in Venezuelan populations of Proechimys
      (Rodentia, Echimyidae) with additional information of Peruvian and Colombian
      populations].

PMID- 1020602
TI  - The control of aldosterone in anephric man.

PMID- 1020603
TI  - [Significant metastic pulmonary calcifications in renal insufficiency with
      chronic hemodialysis].

PMID- 1020604
TI  - [Case of visceral leishmaniasis observed in Belgium].

PMID- 1020605
TI  - Thrombosis of the axillary and subclavian veins following muscular effort (Paget
      Von Schroetter syndrome).

PMID- 1020606
TI  - [Phenformin-induced lactic acidosis. Apropos of 8 cases].

PMID- 1020607
TI  - Inhibitory effect of clofibrate on arginine-induced insulin secretion in chemical
      diabetes.
AB  - Clofibrate 3 g/die for 10 consecutive days, significantly reduced arginine
      induced IRI release in chemical diabetics and in normal controls, whether of
      normal body weight or obese. Blood glucose levels were not affected by
      clofibrate. In agreement with previous findings, it would appear that clofibrate,
      administered for short periods does not lead to a decrease in glucose tolerance.
      However, studies relating to the effect of chronic clofibrate administration in
      chemical diabetes are needed in order to be sure that prolonged inhibition of IRI
      secretion does not lead to overt diabetes.

PMID- 1020608
TI  - Clinical picture of diabetic osteoarthropathy.
AB  - On the basis of data from pertinent literature and of a thorough examination of
      23 cases observed by himself the author illustrates findings concerned the
      occurrence, clinical picture and interrelations of clinical and radiological
      symptoms in diabetic osteoarthropathy. These alterations occur most frequently in
      middleaged or elderly diabetic patients with unstable metabolism or poor control,
      usually after a long duration of diabetes. Clinical symptoms are divided into 4
      groups. Neurological symptoms (group I) are detectable at every stage of the
      process. Sometimes bone destruction is concomitant but neurological changes are
      the sole symptoms. Loose joints and articular swelling (group II) are frequently
      premonitory signs of bone alterations. Plantar ulcers (group III) are often
      associated with bone changes. Detectable foot deformities (group IV) are mostly
      an indication of the end stage of the process.

PMID- 1020609
TI  - Acute self-poisoning with phenformin.
AB  - The case is reported of a non-diabetic young woman who attempted suicide by
      ingesting 2,500 mg of phenformin. The most marked clinical and laboratory
      findings during the first 24 hrs included nausea, vomiting, anxiety, agitation,
      polydipsia, polyuria, increased appetite, tachycardia, tachypnea, persistent
      lactic acidosis, hypoglycemia and hypokalemia. Treatment at the ICU 10 hrs after
      ingestion of the overdose was essentially symptomatic and included measures to
      correct acidosis and hypoglycemia. The patient recovered completely.

PMID- 1020610
TI  - Insulin-induced hypoglycemia: 24-h variation.
AB  - The hypoglycemic effect of i.v. insulin injected at 4 different times of day was
      studied in normal volunteers. It was found that the glucose fall induced by this
      treatment was quantitatively different, with the maximum effect observed at
      18(00) and 24(00). The circadian variation of the insulin-induced hypoglycemia
      depends on the time recovery from the glucose fall rather than on lower
      circulating glucose levels attained following hormone injection. These results
      underline the importance of considering circadian variations when planning either
      experimental designs or insulin therapy.

PMID- 1020611
TI  - Observations on morning and afternoon glucose tolerance: differences between
      sexes.
AB  - One hundred non-obese and non-diabetic individuals, 50 men and 50 women, were
      submitted to oral glucose tolerance tests performed in the morning and in the
      afternoon on different days. Although great individual variations were noted in
      both sexes, in men the mean blood sugar (BS) values did not significantly differ
      between the two tests; in women, however, the mean values after glucose loading
      were significantly higher during the afternoon test. By dividing the test
      population into those aged 50 and below and those over 50 it was found that only
      the group of younger women showed significant differences between the two tests
      with higher mean BS values during the afternoon test.

PMID- 1020612
TI  - Some metabolic and hormonal effects of salbutamol in man.
AB  - The effect of i.v. infusion of a beta-adrenergic stimulant, salbutamol on blood
      insulin, glucose, lactate, phosphates, potassium and NEFA was studied in 9 normal
      subjects. The effect of the drug on the blood sugar and insulin response to i.v.
      glucose was also examined in 4 subjects. Salbutamol was followed by increases in
      insulin, glucose and lactate, and a fall in blood phosphorus and potassium. NEFA
      values did not change significantly. These effects of salbutamol were abolished
      by propranolol and may thus be attributed to its beta-adrenergic stimulating
      action. Salbutamol also induced a reduction in glucose tolerance, in spite of the
      presence of enhanced blood insulin levels.

PMID- 1020613
TI  - Intestinal digestion and absorption of sucrose in experimental diabetes.
AB  - Intestinal sucrose hydrolysis and absorption of monosaccharide products was
      studied in vivo utilizing the segmental perfusion technique in diabetic and
      control rats. The proximal jejunum was perfused with 20 mM sucrose, 140 mM NaCl
      and 0.5% PEG with 14C-PEG, as the nonabsorbable marker. Rates of sucrose
      hydrolysis and adsorption of monosaccharide products (fructose, and glucose) were
      determined. There were no statistically significant differences between the
      diabetic and control rats. This indicates that the previously reported increase
      in sucrase activity in diabetes does not correlate with enhanced rates of sucrose
      hydrolysis. Several possibilities for the interpretation of these results are
      discussed.

PMID- 1020614
TI  - Stimulation of 3H-uridine incorporation into ribosomal ribonucleic acids by
      insulin.
AB  - Ribosomal RNA was extracted from hepatic ribosomal subunits of rats treated with
      alloxan or with alloxan and insulin and additionally injected with 3H-uridine.
      Sedimentation of the extracted RNA through sucrose, gradients with registration
      of the optical density and with measurement of the radioactivity of rRNA reveals
      reduction of uridine incorporation after the induction of diabetes of diabetes
      mellitus. If alloxan-diabetic animals are substituted with insulin, this decrease
      in uridine incorporation is reversed to incorporation rates which even exceed
      uridine incorporation of control animals. With regard to the reduction of protein
      synthesis in diabetes mellitus this finding of reduced rRNA synthesis is
      suggested to be an additional factor in the reduction of ribosomal aggregation.

PMID- 1020615
TI  - Australia antigen in diabetic subjects.
AB  - The sera of 766 diabetics and 730 blood donors have been tested for Australia
      surface antigen (HBsAg). Subjects with a history of an episode of jaundice were
      excluded from both groups. The two groups did not differ as to the frequency with
      which HBsAg was found 1.64% in blood donors, 1.56% in diabetics.

PMID- 1020616
TI  - Maternal diabetes and congenital malformations among live births in Hawaii.
AB  - The frequency of congenital malformations in 187,266 live births in Hawaii from
      1956 through 1966, was found to be significantly higher among offspring diabetic
      mothers (0.0175) than in offspring of non-diabetic mothers (0.0086) or mothers
      with no complications of pregnancy (0.0074). However, the frequency of
      malformations in offspring of diabetic mothers was not significantly higher than
      in offspring of mothers with heart conditions of hypertension.

PMID- 1020617
TI  - [Kinetic characteristics of malate dehydrogenase in the hyaloplasm and
      mitochondria of Xenopus oocytes].

PMID- 1020618
TI  - [Calcitonin and the calcification structure of the membranous labyrinth in the
      developing chick embryo].

PMID- 1020619
TI  - An ultrastructural investigation of the polar plasm of the egg of Sternaspis
      (Annelids, Polychaeta).

PMID- 1020621
TI  - Dynamics of the colonial cycle in the ascidian, Botryllus schlosseri. The fate of
      isolated buds.

PMID- 1020620
TI  - Ribonucleic acid synthesis during development of an ascidian: Ciona intestinalis.

PMID- 1020622
TI  - Endocytosis at the apical surface in neuroepithelial cells of the young chick
      embryo.

PMID- 1020623
TI  - Mitochondria in the egg of Ascidia malaca.

PMID- 1020624
TI  - Investigations on the biosynthesis of sulphur-containing compounds in Limnaea
      (mollusc) oocytes, capsules and jelly during oogenesis period.

PMID- 1020625
TI  - A recessive semi-lethal mutation, "distended lungs" (dl) affecting the tadpoles
      of Xenopus laevis.

PMID- 1020626
TI  - Diploid gynogenetics in Discoglossus pictus.

PMID- 1020627
TI  - On the relationship between the chromosome set and the sexual differentiation of
      the neoblasts in planarians.

PMID- 1020628
TI  - Morphological analysis of the neuroepithelial cells of the chick embryo incubated
      in vitro. A stereological study.

PMID- 1020629
TI  - Evolution of lactate dehydrogenase isoenzymes in two types of skeletal muscles
      and skin tissue in Discoglossus pictus (Amphibia Anura) during embryonic
      development.

PMID- 1020630
TI  - Synthesis of RNA containing poly A in third instar salivary glands isolated
      nuclei.

PMID- 1020631
TI  - [Estimation of the performance spectrum of healthy adolescents by using the PWC
      170 (Physical Work Capacity)].
AB  - On 10 persons we performed maximal rectangular-progressive bicycle-test, with
      measuring of VO2max and maximal work in Watts (Wmax), including the working time
      at the last step. In 18 other young people, we all together made 29 tests without
      spirometry. In addition to Wmax, the PWC 170 was figured out, once with two
      higher ergometer steps and once with two lower steps. We found a high correlation
      between Wmax and VO2max on the one side and PWC 170 and Wmax on the other. If,
      for the PWC 170 will be utilized, two steps with heart-rates of greater than 140
      on the lower and 160 to 170 on the higher step, the PWC 170 seems to be exactly
      sufficient for estimating the maximal physical working capacity for routine
      testing of healthy young people.

PMID- 1020632
TI  - [Early recognition of bone metastases (comparative study between bone
      scintigraphy and x-ray examination)].
AB  - The examination shows, that in search for skeletal metastases the bone
      scintigraphy marks the bone-process in 45% while the X-ray is still silent.
      Therefore, we believe that the first examination in quest of skeletal metastases
      must first be a whole-body scintigraphy and then secondly, an X-ray examination
      with tomography, inasmuch as scintigraphy cannot give an exact differential
      diagnosis (degeneration, inflammation or destruction).

PMID- 1020633
TI  - Ixodes sigelos, n. sp. (Acarina : Ixodidae), a parasite of rodents in Chile, with
      a method for preparing ticks for examination by scanning electron microscopy.

PMID- 1020634
TI  - The effect of presence of females on spermatogenesis and early mate seeking
      behavior in two species of Dermacentor ticks (Acari : Ixodidae).

PMID- 1020635
TI  - [Discordance between the areas of geographical distribution of the hosts and
      feather sarcoptiform mites].

PMID- 1020636
TI  - Effects on the JH-analogues altosid and altozar on the North American house-dust
      mite, Dermatophagoides farinae Hughes (Acarina, Pyroglyphidae).

PMID- 1020637
TI  - Influence of anesthesia on autoregulation of the cerebral blood flow.
AB  - Autoregulation of the cerebral blood flow is a wellknown fact. In normal man the
      arterial pressure can vary from 80 mm Hg to 150 mm Hg without a change in the
      normal cerebral blood flow of 50 ml/100 g/min. The mechanism which is responsible
      for this autoregulation is not clearly understood. Several theories were proposed
      to explain this phenomenon. 1. The tissue pressure increases with an increase of
      the arterial pressure. A mechanical process should neutralize an increase of the
      cerebral blood flow. 2. The metabolic theory says that a decrease of the blood
      pressure, without a change of metabolism, involves an increase of the PaCO2, and
      a decrease of the PaO2. Those two factors provoke a decrease of the vascular
      tone. 3. The myogenic theory explains autoregulation by the fact that a change of
      the transmural pressure in the small vessels, involves a change in the activity
      of the smooth muscles of the vessels. 4. The exact mechanism of the autonomic
      nervous system in the autoregulation of the cerebral blood flow is still obscure.
      In some pathological conditions autoregulation is completely lost or is
      functioning not optimal: hypoxia, hypercapnia and brain contusion. We have
      measured the cerebral blood flow before and after an intravenous injection of 5
      mg thiopental (Pentothal) on occasion of a carotid angiography in man. We noticed
      a decrease of the cerebral blood flow and at the same moment a decrease of the
      arterial pressure. We thought that maybe barbiturates could influence
      autoregulation. Our results could not prove this hypothesis. For ethical reasons
      we could not make the necessary measurements to prove or to reject this
      hypothesis (i.e. intracranial pressure, deep controlled hypotension). In the
      literature there are arguments which support this hypothesis although most
      workers found an intact autoregulation after a barbiturate anesthesia. Some
      workers saw that the increase of the cerebral blood flow by increasing the PaCO2
      was depressed by barbiturates and exhausted by halothane and cyclopropane. As
      autoregulation is a more vulnerable mechanism than CO2 reactivity as seen in
      clinical situations, it could be true that anesthetics do influence
      autoregulation.

PMID- 1020638
TI  - Pneumothorax during anesthesia with changes in ECG.
AB  - A patient known to suffer from CNSLD was to undergo cervical lymph node
      dissection for gingival carcinoma. Pneumothorax developed immediately after
      introduction of anesthesia. In addition to the usual physical diagnostic signs,
      an abrupt decrease in amplitude of the QRS- complex and T -waves was observed in
      the ECG on the scope, the sensitivity of which remained unchanged. The ECG
      changes disappeared after abolition of the pneumothorax.

PMID- 1020639
TI  - A method to exhaust anesthetic gases when using the Loosco system for children
      with an expiratory valve according to the Waters' principle.
AB  - A description is presented of a method to eliminate anesthetic gases when using
      the Loosco system for children with an expiratory valve according to the Waters'
      principle. From practical experience we have gained the strong impression that
      this convenient device meets the requirements we have formulated. Exact gas
      chromatographic determinations are still in progress, and the results will be
      published as soon as possible.

PMID- 1020640
TI  - [Benzoate-caffeine interaction].

PMID- 1020641
TI  - [Determination of the active ingredient content in Quarelin (Algopan)].

PMID- 1020642
TI  - [Chronic administration of chlorphentermine (Desopimon)].

PMID- 1020643
TI  - [Texture and physical properties of directly pressed tablets].

PMID- 1020644
TI  - [The use of the differential scanning method in drug analysis].

PMID- 1020645
TI  - [Equilibrium studies on hemin mixed complexes].

PMID- 1020646
TI  - [The effect of progesterone therapy on the liver].

PMID- 1020647
TI  - [Determination of benzaldehyde contamination in benzyl alcohol].

PMID- 1020648
TI  - [Antifungal effect of the biologically active components of Matricaria chamomilla
      L].

PMID- 1020649
TI  - [Penicillin determination on the basis of spectrophotometric measurements of
      penicillic acid].

PMID- 1020650
TI  - [Spectropolarimetric determination of estrone contamination of ethynyl estradiol.
      The use of spectropolarimetry in drug analysis II].

PMID- 1020651
TI  - [The effect of cellulose derivatives on the physical properties of tablets
      containing sulfonamide derivatives].

PMID- 1020652
TI  - [The effect of mercury (II) acetate on the strength of bases in non-aqueous
      medium. I. Oscillometric and spectrophotometric studies].

PMID- 1020653
TI  - [The effect of mercury (II) acetate on the strength of bases in non-aqueous
      medium. II. Potentiometric studies].

PMID- 1020654
TI  - [A method for the determination of the chamazulene content of chamomile oil].

PMID- 1020655
TI  - Gastric acid secretion inhibitors. I. Compounds chemically related to lidocaine.

PMID- 1020656
TI  - Potentiometric titration of ionizable compounds in two-phase systems. II.
      Determination of partition coefficients of organic acids and bases.

PMID- 1020657
TI  - Quantitative analysis of some penicillins using the differential hydrolysis rate
      method.

PMID- 1020658
TI  - Potential hypolipidemic agents. XV Synthesis and plasma lipid-lowering properties
      of derivatives of 2-phenoxy-2-methylpropionic acid.

PMID- 1020659
TI  - Non-linear curve-fitting analysis of ion-pair extraction equilibria. A comparison
      with slope analysis.

PMID- 1020660
TI  - Testing of laminar air flow units by particle counting and by microbial methods.

PMID- 1020661
TI  - Dry-heat sterilization of pharmaceutical glassware using hot air or infra-red
      radiation.

PMID- 1020662
TI  - Antidepressant agents. VII. Enantiomers of 3,3-diphenylcyclopentylamine and 4,4
      diphenylcyclohex-2-enylamine. Selective inhibition of amine uptake.

PMID- 1020663
TI  - Polysaccharide contaminants in ultra pure grade sucrose with relation to
      anaphylactoid reactions in clinical use of invert sugar solutions.

PMID- 1020664
TI  - [Neuroregulation of respiration. An attempt at synthesis].

PMID- 1020665
TI  - Hepatic glucoreceptors in the short-term control of feeding.

PMID- 1020666
TI  - [Skeletal muscles and the organ of locomotion].

PMID- 1020667
TI  - [Motility of the digestive system and its neural and humoral regulation].

PMID- 1020668
TI  - [Hyperbarism and systemic homeostasis].

PMID- 1020669
TI  - [Influence of the population on the physiologic mechanisms of the body].

PMID- 1020670
TI  - [Inheritance of traits in animals in the light of physiological studies].

PMID- 1020671
TI  - [Genetic conditioning of some physiological and psychomotor traits in the aspect
      of the individual's development].

PMID- 1020672
TI  - [Classification of methods of creating conditioned reflexes].

PMID- 1020673
TI  - [Macromolecular systems of the living world].

PMID- 1020674
TI  - [Value of information in a living system].

PMID- 1020675
TI  - [Nervous regulation of blood circulation at the level of cerebral neurons].

PMID- 1020676
TI  - [Regulation of mesenteric circulation].

PMID- 1020677
TI  - [Cellular mechanism of inotropic action of acetylcholine in the heart].

PMID- 1020678
TI  - [Myocardial energetics within the frame of mechanisms responsible for the
      circulatory equilibrium].

PMID- 1020679
TI  - [The borderline structure: Rorschach of architecture students].

PMID- 1020680
TI  - [Affective perception of the body in neurotics. Its relation to anxiety,
      depression, and various types of defense].
AB  - This study compares and relates affective bodily perception (ABP), anxiety,
      depression, and the utilisation of some defense mechanisms in 25 neurotic women
      (16 depressives, 9 hysterical) and 25 normal women. ABP is evaluated according to
      satisfaction and anxiety (Body cathexis scale), distorsions (Body distortion
      questionnaire) and body conscience (Body prominence). Anxiety is measured with
      Cattell questionnaire, depression through Zung and Hamilton scales, and defense
      mechanisms by the Firo Form Cope of Schutz. Neurotics have a ABP more negative
      and are more depressed and anxious than normals; they use more regression while
      controls tend to use introjection. In comparison with depressives, hysterical
      women have higher scores in body distortion, mostly in the feeling of boundary
      loss; they express more masked anxiety and react more often through projection.
      Among neurotics, those who have a very disturbed ABP are more anxious, more
      depressed, and more prone to denial, projection, and regression in comparison
      with the others. In both samples, anxiety and depression have a negative
      correlation with body satisfaction and a positive one with body distortions and
      somatic anxiety. In the control group, body satisfaction is inversely related
      with feeling of dirt. Somatic anxiety is also inversely related to unusual
      feelings of body and skin obstruction. The intensity of body consciousness is
      related to using isolation and distortions are negatively related to using
      denial. In neurotics, denial is in opposition with the intensity of body
      awareness and is linked to somatic anxiety. The intensity of body awareness is
      also correlated to various forms of anxiety. Distortions are positively related
      to regression. The comparison of both samples shows a degradation of ABP in
      neurotics. The study of correlations clarifies several relations between
      deficient ABP anxiety, depression and the use of some defense mechanisms.

PMID- 1020681
TI  - [Mental health community centers in the United States].
AB  - After defining the concept of the Community Mental Centers and giving an overview
      of the principles, the author describes the five most needed ways for the
      operationalization and the implementation of the community approach in mental
      health care. The results, i.e. the successes, of the community mental health
      programme in the USA are discussed and also the various shortcomings: private
      psychiatrists and general practitioners are not integrated enough; overestimation
      of the need for the number of psychiatric beds; need for cost analysis of the
      consultation and education part of the programmes in connexion with the need for
      adequate reimbursement; an evaluation programme should have been built in from
      the beginning; with the tremendous increase in personnel costs and the general
      inflation of cost price, some parts of the programme are not financially
      competitive with the private psychiatric practice; two parallel systems still
      emerge, the CMHC and the State hospitals, frequently with not enough
      collaboration; and finally, the "yavis" phenomenon with neglect of the unwanted,
      difficult, chronic patient, especially the defected schizophrenics.

PMID- 1020682
TI  - Safety and efficacy of prolonged treatment with Tremblex (dexetimide), an
      antiparkinsonian agent. A controlled study.
AB  - The trial involved 69 female, long-stay inpatients of the Voorburg mental
      hospital, of a median age of 50 years. Two groups were formed at the start of the
      trial. The first group (51 patients) on a maintenance therapy with orphenadrine,
      were now put on oral dexetimide. Individually adapted dosages ranged from 0.5 to
      1.5 mg daily. The control group (18 patients) of antiparkinsonian agents did not
      take any in the course of the study either. After three and six months (end of
      trial) biochemical and haematologic parameters were assessed. Clinical evaluation
      of extrapyramidal symptoms was made in the dexetimide group. All patients of the
      control group and 47 of the dexetimide group completed the trial. Both groups
      were shown to be comparable with regard to all parameters. Statistical analysis
      showed significant improvement in dexetimide-patients with regard to gross motor
      tremor, facial inexpressiveness, parkinsonian gait (after two weeks) + dyskinesia
      (after six months).

PMID- 1020683
TI  - A retrospective evaluation of long-term fluspirilene (IMAP) treatment.
AB  - Fluspirilene proved to be a very useful drug in the basic maintenance therapy of
      21 chronic schizophrenic patients (ages 16-71 years), who received individually
      adjusted doses weekly during their hospitalization and during the subsequent
      follow-up period. The follow-up data analysis showed that the antipsychotic
      efficacy of the drug after prolonged (8-21.5 months) treatment was nicely
      maintained, that the patients' socio-professional integration had improved
      significantly, while a small decrease in dosage proved possible in several cases.
      The incidence of side-effects remained low, and no signs of accumulation or
      toxicity could be detected.

PMID- 1020684
TI  - [Clinical study of Haldol at high doses in chronic schizophrenia].
AB  - The authors have studied the action of high doses of Haldol in chronic
      schizophrenics in a study lasting more than five months and compared their
      results to a study done at the Eastern State hospital of Williamburg in Virginia
      (U.S., Howard). The daily doses of 75 mg caused a remission in 4 schizophrenics,
      and 19 patients were improved in a sample of 38 patients. The medication was
      given to a group exposed to neuroleptics only, without differences between the
      two groups. The authors have carried out the study for more than one year without
      observing changes in biological tests, using a dayly dose of 60 mg. Five patients
      out of nine were improved and could be discharged to return to their family or
      society with the appropriate affective follow-up.

PMID- 1020685
TI  - [Lithium salts in manic-depressive psychoses (cyclophrenia)].
AB  - In psychiatry, lithium salts are used alone, or in combination with neuroleptics,
      in the treatment of manic states and in the prophylaxis of manic or melancholic
      relapses in cyclophrenia. They are also used by some clinicians to prevent
      relapses of melancholia. To be efficient, the blood level of lithium must be
      between 0,8 and 1,2 mEq/liter in chronic treatment, and much higher in acute
      treatment. Side effects can be present, but do not warrant to stop the treatment;
      meanwhile there are signs of intoxication which necessitate immediate treatment
      interruption. This medication should be given to motivated patients, of normal
      intelligence, suffering from repeated states of mania or melancholia, because it
      is a long term treatment requiring constant supervision.

PMID- 1020686
TI  - [Contingent negative variation and mental disorders].
AB  - This work, dealing with negative contingency variation (NCV) in mental patients,
      is in the general frame of research aiming at establishing correlations between
      biological phenomenons and psychic entities. The results can be examined in three
      different directions. 1. In the electrophysiological perspective they have
      individualized a series of physiological forms and brought a real nomenclature.
      2. In an electro-clinical perspective, they have allowed to oppose normal curves
      (NCV, type I, responses to sensory stimulations type A, B, C and motor potential
      type N) and abnormal curves (NCV zero or type III, IV, responses type D and motor
      potential type P). One must however stress that this distinction is only valid if
      one studies adult subjects and awaken, and contributes only an index of non
      specific morbidity. Furthermore, considering two more electrophysiological
      criteria--the mode of combination of various curves and the stability of NCV--can
      help establishing a severity scale and modeling the above data. 3. In a
      physiopathological perspective, they have lead to discussing two hypotheses
      concerning the functional signification of prolonged NCV; one being a prolonged
      state of awaiting, the other a mode of particular reaction to imperative
      stimulation, and to demonstrate that it is not possible to consider only one and
      same system to explain all clinical categories. Thus, in this new area of slow
      cerebral potentials, as in clinical electroencephalography, is illustrated the
      teaching of the functional electroencephalography through the school of Paris
      where similar electric patterns have different significations when present in
      opposed psychological organisations.

PMID- 1020687
TI  - [Hysteria and psychosomatic disorders in Portuguese immigrants].
AB  - Seventy patients presenting symptoms of hysteria (49 women and 21 men) were
      selected among patients observed at the Institute Minkowska during the year. This
      work is part of a research work on socio-cultural and environmental factors which
      can change mental status of immigrants. These are all portugese workers
      presenting for the first time atypical mental troubles called by the author:
      "bastard hysterical syndrome of the immigrant" and characterized partly or
      totally by the following symptoms: fatigue, anxiety, sense of suffocation,
      dyspnea, coughing, unilateral chills or generalized chil, abdominal or gastric
      pains, headaches and "diffused pains", paresthesia, aching back, tears and
      sorrow, fear of dying or having a cancer, asthenia, leg paresthesia and
      contractions, vomiting, diarrhea, cardiac pains, palpitations, dizziness and
      collapsing. These troubles appear sometimes without apparent motives but they are
      almost always due to a precipitating cause expressed by the patient: a delivery,
      a familial death, a homosexual proposition, a trauma without importance, a
      working conflict etc... But the most frequent cause invoked is "the french
      climate" without knowing precisely what the word "climate" means: atmospheric
      conditions, athmosphere or reception milieu? This latest interpretation seems
      more likely after months of psychotherapy. Most patients are not french speaking
      and cannot write; their origin is rural (familial villages well structured
      regarding their food and sexual economy), and people well "armed" by a system of
      defense mechanisms and well adopted conditioned reflexes. In this work, hysteria
      of the portugese immigrant is compared to childhood hysteria. As the hysterical
      burst of the child is aimed at calling attention, love of the mother, at finding
      a solution to a familial or social conflict, the hysterical burst of the
      immigrant is aimed at the absent family or at its substitutes, the bos, social
      security, the doctor. Furthermore, the attitude of the hosting Country--wanting
      and rejecting--is very ambivalent; "tenderness" at the time of reception,
      followed by indifference. Early attentions are followed by constant interdictions
      (threat of unemployment, false statements on sexual dangers of the immigrant
      etc;..). The immigrant, like the hysterical child, is periodically controlled
      (work and visit cards), supervised (supervisors), The narcistic satisfactions of
      being called a good worker can be followed by threats of firing in economic
      crisis. The society of the hosting country requires the immigrant to be identical
      to this society: language, physical appearance, food. The real paradoxical
      situation to which the immigrant is confronted and the real or hypothetical fears
      constitute conditions of experimental neurosis, to which portugese immigrants
      react very often by a bastard symptomatology of hysterical type, characteristic
      of displaced man. These preliminary studies are the frame for a future
      epidemiological survey in this specific population.

PMID- 1020688
TI  - A note on the relative prevalence of phobic reactions in an Iranian psychiatric
      population.
AB  - Ths study was undertaken to investigate the prevalence of phobic reactions among
      the patients referred to the University of Teheran Psychiatric Hospital during
      1975. It was found that about 10% of the total population studied manifested
      symptoms of phobia, which of course indicate different therapeutic modality to be
      considered in their treatment. One could easily notice that this proportion is
      much higher than what has been reported by Marks. It was further found that
      darkness, nyctophobia, necrophobia, ochlophobia, ailurophobia and pet animals and
      fear of cancer and syphilis accounted for 79% of the phobic cases studied.

PMID- 1020689
TI  - [Application of a geriatric evaluation scale to patients of a closed psychiatric
      hospital].
AB  - The geriatric scale of Stockton (SGRS) was applied to 135 subjects aged 60 or
      more (women in a closed psychiatric hospital). This scale differentiates between
      organic states (dementia) and other diagnoses. The scores are not correlated to
      subjects' age in dementia. The SGRS also furnishes interesting indications on
      aging according to various diagnostic groups.

PMID- 1020690
TI  - [Psychodynamic aspects of personality of patients with Parkinsonism].
AB  - After reviewing the literature on personality and Parkinsonism and recalling the
      two concepts which conflict on the etiology of their personality, the author has
      examined Rorschach charts of 20 Parkinsonians. This was done through formal
      analysis and content analysis in order to show the various dynamic aspects of
      personality, the psychic mechanisms preferentially used and the possible
      relations between psyche and soma. The results reveal a modification of
      personality in the direction of global narrowing, on ideas and affect, a
      reduction of relational investments, a narcissitic and hypochondriac retrieval
      and an important reduction of affects. Two different types of personality appear
      out of this common branch. The first is characterized by rigidity and stereotipy,
      the second characterized by some smoothness and a wider opening toward the
      external world. The psychodynamic study reveals that personality reorganization
      takes place through libidinal retrieval, through defensive and narcissisic move.
      After the completion of the study, the somatopsychic hypothesis remains most
      produce; however the premorbid personality and in particular the aggressive
      problem can integrate with the behavioral modifications due to Parkinson's
      disease in order to finally bring a original psycho-affective picture.

PMID- 1020691
TI  - [A kibbutz group].
AB  - Kibbouts-group: three therapeutic or growth factors together: manual work,
      community life and group technics (group dynamic, Gestalt, psychodrama, bio
      energetic) during two weeks. The work of growing and therapy is becoming more
      concrete and facilitated by the absence of difference between members and leader
      who share the work and the community life. Important and rapid changes are
      frequent: a particular attention is given to the "unmedicalisation" of symptoms
      (fatigue) and to the "unpsychiatrisation" of conflicts. A sample and authentical
      life style, together with a high degree of communication, favor the desinhibition
      of attitudes, the clarification of conflicts and the reenforcement of the
      personality.

PMID- 1020692
TI  - Antidepressive properties of I-glutamine. Preliminary report.
AB  - A brief review of the literature on this topic, and a comparison of the results
      obtained in children by administrating l-glutamine with those obtained by other
      antidepressive drugs, is primarily presented. Having been tested in a sampler of
      43 adults, affected by different forms of depressive, neurasthenic and
      dissociative illnesses, 1-glutamine is indicated as owning clear anti-depressive
      properties, and the asthenia as target-symptom for its therapeutical use. Out of
      the endogenous depression with slowed-down motor activity, indeed good results
      were found in all cases, in which a "vital" level had been reached by the
      illness. Since 1-glutamine is noticed being a precursor of GABA, this fact itself
      could explain its antidepressive properties, but it is necessary to remember that
      they very complex metabolism of the drug is still mostly unknown.

PMID- 1020693
TI  - A progress in electroconvulsive therapy: the non-barbiturate anesthaetic drug
      etomidate.
AB  - Forty-six female patients (19-72 years) requiring ECT for psychiatric indications
      received 0.5 mg atropine, followed by 0.1-0.4 mg/kg bodyweight of etomidate.
      Subsequently 50 mg of suxamethonium were injected and ECT was applied. The
      etomidate-ECT combination proved very suitable and was well tolerated.

PMID- 1020694
TI  - Character neuroses and behavioural disorders in children: their treatment with
      pipamperone (Dipiperon). A clinical study.
AB  - Dipiperon drops 30-180 mg/day were given for eight weeks to 29 children with
      character neuroses and behavioural disorders. A 16-item rating-scale covering
      several features of behaviour disorder was completed by a psychologist and a
      teacher independent from each other. The individual number of pathological scores
      showed a decrease already within the first treatment week and a further decrease
      by the end of the trial, especially for the items of capriciousness, obstinacy,
      irritability and restlessness. The therapeutic benefit was not accompanied by an
      adverse effect on the school performance of the children. No side-effects were
      reported or observed.

PMID- 1020695
TI  - Stability of mammalian tuberculin PPD.
AB  - Six lots of PPD prepared in 1937 met the requirements when tested in guinea pig
      potency assay in 1974. Reading of the skin reactions at 48 hr gave more
      consistent results than the 24 hr reading. Data were evaluated by analysis of
      variance and by a quick method developed for the estimation of identity of the
      standard and the test preparation. Although less sensitive than the analysis of
      variance, the quick method has been found suitable for estimation of the potency
      of tuberculin preparations.

PMID- 1020696
TI  - Decreased cellular immune response of germ-free mice.
AB  - Cellular immune response to intracerebral lymphocytic choriomeningitis infection
      was studied in mice belonging to an identical strain but different in breeding
      conditions. In consequence of the cellular immune reaction on the leptomeninx,
      lymphocytic choriomeningitis developed and caused death in 100% of conventionally
      bred mice, whereas 80% of germ-free and 15% of mouse-pathogen-free mice failed to
      display lymphocytic infiltration of the leptomeninx and survived the infection as
      chronic virus carriers. This finding pointed to a deficient cellular immune
      response of germ-free and mouse-pathogen-free mice. The under-development of the
      lymphoid system due to the antigen-poor breeding conditions might be responsible
      for the deficiency.

PMID- 1020697
TI  - Studies on the lymphoid system of mice with lethal acute toxoplasmosis.
AB  - Acute toxoplasmosis was induced in CFLP mice by infecting them intraperitoneally
      with the 25 x 10(3) multiplicity of the virulent RH strain of Toxoplasma gondii.
      The lymphoid system of mice succumbing to acute toxoplasmosis showed
      characteristic changes. Significant spleen hypertrophy (spleen index: 1.76),
      severe thymus atrophy (thymus index: 0.27) and a striking decrease of the
      lymphocyte count in blood (86%) was found as compared with the uninfected
      controls.

PMID- 1020698
TI  - Leukocyte migration inhibition by a specific antigen in human typhoid fever.
AB  - Cellular reactivity to heat-killed Salmonella typhi antigen was investigated by
      the leukocyte migration inhibition (LMI) method in 33 S. typhi infected patients
      and in 32 control persons. In the typhoid group a statistically significant LMI
      was observed as compared to the members of the control group. A correlation was
      found between the level of the cellular sensitivity and the time elapsed between
      onset of the disease and performance of the test. Previous typhoid vaccination
      had no influence on the LMI. No correlation was found between the agglutinin
      titres and the sensitivity demonstrated by the LMI test. The value of the method
      in studies of cellular immunity in typhoid fever is discussed.

PMID- 1020699
TI  - The development of the connective tissue in the human orbit.
AB  - The development of the mesenchymal structures of the human orbit was studied
      using 10 mu or 60 mu serial sections of orbits of foetuses of 35 to 320 mm stages
      (C.R. length; 2-9 months). The ontogenesis of the orbital walls, the eye muscles,
      the blood vessels and the connective tissue was compared. This comparison
      revealed that the eye muscles and their fasciae together with the adventitial
      layers of the larger blood vessels and nerves develop first, closely linked in
      time to the progress of ossification and growth of most of the orbital bones.
      Only the (endochondral) ossification of the ethmoid starts much later. The
      orbital connective tissue septa development commences later, i.e. from the third
      month onwards, concurrently with the development of special mesenchymal
      condensations, a particular capillary system and adipose tissue. About five
      months later the adult configuration is attained.

PMID- 1020700
TI  - Functional anatomy of the musculature of the trachea.
AB  - The smooth musculature of the human trachea was studied and compared with earlier
      observations in the rabbit. The results may be summarized as follows: 1. The
      annular m. constrictor tracheae, previously observed in the rabbit, has also been
      identified in the human trachea. 2. Longitudinal muscle fibers outside the
      constrictor musculature were observed in man. These fibers are rudimentary and
      appear to be of no functional importance. 3. From a functional point of view, it
      appears justified to regard the outer tracheal musculature largely as a
      constrictor musculature. 4. The main function of the outer musculature of the
      trachea and the elastic cartilaginous arches is to maintain the stability of the
      tracheal wall. 5. The variation of the lumen of the trachea is mainly controlled
      by the m. trachealis in the pars membranacea.

PMID- 1020701
TI  - [Development of the intestines. Human embryos].
AB  - In the present study an attempt was made to think over anew the development of
      the peritoneal situs, guided by the comparison of the "root-area" (the connective
      tissue area free of peritoneum between the left and right transition line of the
      peritoneum parietale to the peritoneum viscerale) of the so-called "primitive
      mesentery" of an embryo (10 mm CRL) and of an older fetus (250 mm CRL). The
      following results were obtained: The so-called primitive sagittal mesentery
      cannot be regarded as the anlage of the adult mesentery, in the sense that the
      latter develops out of the former dy displacement of rotation. The original "root
      area" widens with the broadening of the back and can still be demonstrated as an
      homogeneous "root area" of the "intestinal bulge", after the typical adult situs
      has developed. There is a connection between the development of the mesenteries
      and the formation of the folds of the embryonic serosa. Their position is
      determined through the recesses of the intestinal bulge. They exist because of
      the foldings and are therefore secondary characteristics. Under these aspects it
      is possible to consider the development of the situs as a uniform folding process
      of the embryonic serosa, without references to as yet unproved secondary
      adhesions of the peritoneal layers.

PMID- 1020702
TI  - Effect of long photoperiod on the maturation of ovary of the catfish, Mystus
      tengara (Ham.)
AB  - A study has been made of the effect of photoperiodism on the ovarian maturation
      of fresh water teleost, Mystus tengara (Ham.). The magnitude of ovarian
      recrudescence is more during maturing virgin phase as compared to during immature
      virgin and preparatory virgin phases in long photoperiod (14 hours/day) treated
      fish. Thus, the response of the ovary to long photoperiod increases with the
      approach of natural spawning period. The mature eggs are more in long photoperiod
      treated fish than in controls exposed to 12 hours/day photoperiod. In long
      photoperiod treated fish, prespawning period is reduced considerably. During
      spawning and post-spawning periods, the ovaries are refractory, since long
      photoperiod is ineffective in maintaining gravid ovaries beyond spawning period
      and the ovarian regression during post spawning period sets in regardless of
      nature of photoperiod treatment.

PMID- 1020703
TI  - [The odontostomatologist confronting the diabetic patient].

PMID- 1020704
TI  - [Pregnancy and odontostomatologic therapy].

PMID- 1020705
TI  - [Osteosynthesis of mandibular fractures].

PMID- 1020706
TI  - [Case report of a complete labiomandibular median cleft].

PMID- 1020707
TI  - [Delayed mineralization of premolar tooth germs and premolar supernumerary tooth
      germs: consequences in dentofacial orthopedics].

PMID- 1020708
TI  - [Treatment of severe interadicular bone lesions].

PMID- 1020709
TI  - [Oral vibrions method of isolation and demonstration of their relation to
      Sherophorus fusiformis].

PMID- 1020710
TI  - [Oral protozoan diseases: experimental possibilities[].

PMID- 1020711
TI  - [Scanning electron microscopy of the structure of the human dentin].

PMID- 1020712
TI  - Altered composition and metabolism of proteoglycans isolated from degenerated
      human articular cartilage.

PMID- 1020713
TI  - Binding of 25-hydroxycholecalciferol in plasma of normal and vitamin D -
      deficient chicks and men.

PMID- 1020714
TI  - Relase of retraction stimulating factor (RSF) during platelet dependent
      retraction of reptilase clots.

PMID- 1020715
TI  - Computer simulation of iodine inhibition system with TSH regulation.

PMID- 1020716
TI  - Somatic changes in the course of and as consequence of pregnancy.

PMID- 1020717
TI  - Platelet shape change induced by cold and the retraction of reptilase clots.

PMID- 1020718
TI  - [Abuse and insufficiency in urinary radiology].

PMID- 1020719
TI  - [Abuse and insufficiency in urinary radiology].

PMID- 1020720
TI  - [The place of nephroangiotomography in radiologic studies of renal masses].

PMID- 1020721
TI  - [Extravasation of urine and intravenous urography].

PMID- 1020722
TI  - [Abuse and insufficiency in urinary radiology].

PMID- 1020723
TI  - [Abuse and insufficiency in urologic radiologic].

PMID- 1020724
TI  - [Abuse and insufficiency in urinary radiology. Value of arteriography in
      pyelocaliceal imprints].

PMID- 1020725
TI  - [Abuse and insufficiency in urinary radiology].

PMID- 1020726
TI  - Studies on bone development in pigs diseased in atrophic rhinitis.

PMID- 1020727
TI  - Experimental transmission of Eimeria stiedai to the hare.

PMID- 1020728
TI  - Histopathological changes in the gizzard of goslings, ducklings and chickens
      experimentally infected with Amidostomum anseris.

PMID- 1020729
TI  - Data on the aetiology of swine atrophic rhinitis. V. The role of genetic factors.

PMID- 1020730
TI  - Effect of high air temperature on the fasting metabolism of fattening pigs.

PMID- 1020731
TI  - Experimental transfer of enzootic bovine leucosis to sheep.

PMID- 1020732
TI  - Rehabilitation of work dogs diseased in hip dysplasia by surgical application of
      a gelatine interpositum.

PMID- 1020733
TI  - Radiography of the hip joint in standing dog.

PMID- 1020734
TI  - [Radiochemical detection of microelements in veterinary toxicological studies and
      veterinary food hygiene examinations].

PMID- 1020735
TI  - [Pharmacokinetics of various sulfonamide-trimethoprim combinations in newborn
      calves].

PMID- 1020736
TI  - Effect of the moistening of body surface on heat production and heat sensation in
      fattening pigs.

PMID- 1020737
TI  - The abnormal upper gastrointestinal vagovagal reflexes that affect the heart.
AB  - The clinically important upper gastrointestinal-cardiac vagovagal reflexes are
      mainly those initiated by swallowing and rapid gastric distention. Pre-existing
      heart disease has little to do with determining susceptibility to upper
      gastrointestinal stimuli. The dangerous cardiac repercussions concern diminished
      coronary artery flow and the arrhythmias. The latter can be subcategorized as
      swallow tachycardia, pharyngeal disease with arrhythmia, glossopharyngeal
      neuralgia with swallow syncope, spontaneous swallow syncope and swallow
      bradycardia. Iatrogenic arrhythmias are particularly tragic potential hazards of
      all pharyngoesophagogastric manipulations.

PMID- 1020738
TI  - Endoscopy of the upper gastrointestinal tract.
AB  - Fiberendoscopy of the upper gastrointestinal tract recently has become a routine
      diagnostic procedure. This is due to its broad spectrum of applications and to
      its "reputation" of simplicity and innocuousness. The possible complications of
      fiberendoscopy, however, are similar to those of rigid endoscopy. Most of these
      complications can and must be avoided by strict adhesion to elementary
      precautions: adequate teaching and supervision of endoscopists in training;
      emphasis on all stages of the patient's preparation, psychological and
      pharmacological, each adopted to the individual patient and constant awareness of
      the possibility of complications.

PMID- 1020739
TI  - Diagnosis of gastric prepyloric and antral lesions: comparison of fiberendoscopy
      and gastric biopsy with radiology.
AB  - Fibergastroscopy and direct-vision gastric biopsy were performed in 47 patients
      who had a prepyloric or antral gastric lesion on barium meal (single-contrast)
      examination. Of 27 cases with a radiological diagnosis of prepyloric or antral
      ulceration, five cases (18.5%) had evidence of ulceration, 12 cases (44.4%) had
      acute or chronic gastritis and eight cases (29.6%) had normal gastric mucosa, on
      fibergastroscopy. Multiple gastric biopsy confirmed the presence of acute-on
      chronic gastritis (ACG), chronic gastritis (CG) and chronic atrophic gastritis
      (CAG), with or without intestinal metaplasia (IM) or epithelial atypia (Aty), in
      24 cases (89%). Normal gastric mucosa was found in three cases (11%) and
      malignancy in none. Of 15 cases with a radiological diagnosis of prepyloric or
      antral malignancy, only three cases (20%) had evidence of adenocarcinoma on
      endoscopy and biopsy. One case had rounded nodules seen on endoscopy and gastric
      biopsies showed malignant lymphoma. In two cases with endoscopic suspicion of
      malignancy, gastric biopsies showed ACG in one and CAG in the other. Gastric
      biopsies showed histological changes of CG (+/- IM) or CAG (+/- IM) in 11 cases
      (73%). In five cases with a radiological diagnosis of various prepyloric or
      antral lesions, endoscopy and biopsy revealed CG (+/- IM) in all and malignancy
      in none. It is concluded that fiberendoscopy and gastric biopsy are superior to
      the single-contrast barium meal in the diagnosis of prepyloric or antral gastric
      lesions. Direct-vision gastric biopsy should be done in all cases since it
      increased the diagnostic accuracy of fiberendoscopy.

PMID- 1020740
TI  - Treatment of protein-losing gastropathy with atropine.
AB  - Protein loss from the gastric mucosa with hypertrophic gastric folds and
      hypoalbuminemia has been associated with low, normal and elevated gastric acid
      output. A case of protein-losing gastropathy with slightly elevated gastric acid
      output is described. Associated findings were hypertrophic gastric folds,
      hypoalbuminemia, hyperlipidemia, lymphadenopathy, edema, ascites and venous
      thrombosis. Oral administration of atropine resulted in a cessation of
      gastrointestinal protein loss and correction of hypoalbuminemia.

PMID- 1020741
TI  - Biliary excretion and concentration of cefazolin.
AB  - The excretion of cefazolin into the human biliary tract in health and disease was
      investigated in 34 patients undergoing surgical procedures. The patients
      included: I. Four controls. IIA. Eleven patients with cholelithiasis and/or
      cholecystitis and a radiological visualized gallbladder. IIB. Nine patients with
      cholethiasis and cholecystitis and a radiologically nonvisualized gallbladder.
      III. Five patients with obstructive jaundice. IV. Five patients with a T-tube in
      the common bile duct. Two dose regimes: 1. A single dose of 500 mg and 2. four
      doses each of 500 mg. given every six hours, were used. Samples of serum,
      gallbladder bile, common duct bile and gallbladder tissue were assayed for
      antibiotic activity by the cylinder plate method with Bacillus subtilis.
      Following administration of four doses of the antibiotic, the mean level of the
      drug in the gallbladder bile, in controls was 127.0 mug/ml. In the group with
      cholelithiasis and cholecystitis and a gallbladder that is visualized, a similar
      high level was noted (mean = 132.2 mug/ml.). In the presence of a nonvisualized
      gallbladder or obstructive jaundice, the levels in bile were lower. Two hours
      following a single injection of the drug, the level in the common duct bile
      reaches a peak of 10 mug/ml and at eight hours falls to less than one mug/ml. In
      the absence of obstruction cefazolin reaches a significantly high level in bile
      and could be valuable in treatment of biliary infections.

PMID- 1020742
TI  - The pancreatic involvement in disseminated "collagen" disorders. Studies of
      pancreatic secretion in patients with scleroderma and Sjogren's "disease".
AB  - In this study of 66 patients with Sjogren's syndrome and/or scleroderma abnormal
      pancreatic secretory patterns were observed in 43 patients, 17 of 23 with
      Sjogren's and 19 of 31 with scleroderma. Pancreatic insufficiency was often
      associated with depressed gastric secretion and/or abnormal gallbladder function.
      While in both disorders digestive complaints are attributable to one or more
      dysfunctions, the pathogenetic factors in scleroderma appear to be more varied
      and require careful investigation for complete elucidation. Antibiotics,
      antimetabolites and steroid therapies are also additional causal factors involved
      in the initiation of gastrointestinal dysfunction and pathology.

PMID- 1020743
TI  - Electrocoagulation biopsy of aberrant pancreas of the stomach. A case of aberrant
      gastric pancreas.
AB  - Histopathological diagnosis of submucosal tumors of the stomach has been
      difficult by conventional examination, e.g. roentgenography, gastroscopy and/or
      routine biopsy procedure. When endoscopic diagnosis of submucosal tumor is made,
      surgery is generally performed for tissue biopsy. We have been attempting to
      avoid such exploratory laparotomy to determine the histologic nature of small
      asymptomatic submucosal tumors of the stomach by a technic of endoscopic biopsy
      followed by electrocoagulation. With such a procedure, we have been able to
      diagnose a case of aberrant pancreas of the stomach. Our experience suggests that
      this technic is a safe and useful diagnostic tool.

PMID- 1020744
TI  - Meckel's diverticulitis due to Schistosomiasis mansoni.
AB  - An unusual case of schistosomal Meckel's diverticulitis is presented. Parasites
      were subsequently found in either stool or rectal biopsies of three siblings. The
      possibility of serious sequels makes the early diagnosis of Schistosomiasis
      mansoni often by simple stool and rectal biopsy examination particularly
      valuable.

PMID- 1020745
TI  - Brunner's gland adenomas associated with high-output congestive heart failure.
AB  - Brunner's gland adenoma in the third portion of the duodenum is rare and only two
      such cases have been reported previously. A 35-year old man presented with high
      output congestive heart failure. Profound iron deficiency anemia was corrected by
      transfusion, allowing detection of a duodenal tumor, which proved pathologically
      to be a Brunner's gland adenoma.

PMID- 1020746
TI  - Large gastric varix simulating tumor.

PMID- 1020747
TI  - The training of primary care internists and primary care subspecialists at Emory
      University School of Medicine.

PMID- 1020748
TI  - Sorbents in the management of uremia.

PMID- 1020749
TI  - The early detection of airway obstruction: another perspective.

PMID- 1020750
TI  - The clinical recognition of dissecting aortic aneurysm.
AB  - The clinical, roentgenologic and laboratory findings in 124 patients with
      dissecting aneurysm of the aorta are reported. In 53 patients the dissection
      occurred in the ascending aorta ("proximal" dissection), and in 71 patients the
      site of origin was the descending thoracic aorta ("distal" dissection). Certain
      distinct clinical differences between the groups were apparent. Although
      hypertension was an important predisposing factor, it was significantly more
      common in distal dissection, as was atherosclerosis. Back pain and hypertension
      on hospital presentation characterized patients with distal dissection.
      Conversely patients with proximal dissection were younger and had a significantly
      higher incidence of Marfan's syndrome, cystic medial necrosis, anterior chest
      pain, pulse deficits, neurologic compromise, aortic insufficiency and congestive
      heart failure. In both groups, syncope appeared to correlate well with the
      occurrence of cardiac tamponade. Chest roentgenograms almost always showed an
      abnormal aortic contour. Aortic angiography, when performed, was usually
      confirmatory of the diagnosis.

PMID- 1020751
TI  - The clinical course, early prognosis and coronary anatomy of subendocardial
      infarction.
AB  - The following prospective study was undertaken to observe the clinical course,
      early prognosis and coronary anatomy of patients with subendocardial infarction.
      Subendocardial infarction was defined as typical chest apin (greater than 15
      minutes), serum enzyme elevation and persistent (greater than 48 hours) new T
      wave inversion and/or S-T segment depression in the absence of new pathologic Q
      waves. Fifty consecutive patients were defined, followed in a prospective manner
      and subjected to early coronary arteriography. A prior history of unstable angina
      was found in 33 patients (66 per cent); 22 patients (44 per cent) had significant
      dysrhythmias during the acute hospital phase, and seven patients (14 per cent)
      had evidence of mild left ventricular failure. Coronary arteriography
      demonstrated significant lesions (greater than 75 per cent narrowing in at least
      one vessel) in all 50 patients, with 30 patients (60 per cent) having either
      double- or triple-vessel disease. Follow-up (mean 10.6 months) revealed that 15
      patients (30 per cent) had stable angina, 23 patients (46 per cent) unstable
      angina and only 12 patients (24 per cent) remained free of angina. Of 28 patients
      in a medically treated group, acute transmural infarctions developed in six (21
      per cent) and one died (3 per cent). We conclude that subendocardial infarction
      is symptomatically an unstable entity, is associated with severe coronary artery
      disease and, in a medically treated group, is followed by a significant incidence
      of early transmural myocardial infarction (21 per cent). Therefore, these
      patients require in-hospital monitoring, careful follow-up and consideration for
      early coronary arteriography.

PMID- 1020752
TI  - The relation of sinus rate to the frequency of paroxysmal ventricular tachycardia
      during acute myocardial infarction in man.
AB  - Continuous tape recordings of cardiac rhythm were made in 51 male patients with
      acute myocardial infarction within 24 hours of their infarction. These tracings
      were analyzed for the incidence of paroxysmal ventricular tachycardia (PVT) and
      the sinus rate immediately preceding each episode of PVT. In 26 patients, 112
      episodes of PVT at a rate greater than 100 beats/min were documented. Although 67
      per cent of the episodes of PVT were preceded by sinus rates between 60 and 100
      beats/min, 15 per cent occurred at sinus rates below 60 beats/min and 18 per cent
      occurred at sinus rates above 100 beats/min. The data remained essentially
      unchanged regardless of whether ventricular tachycardia was defined at rates in
      excess of 100, 120 or 140 beats/min. The results of this study show that during
      the early phases of acute myocardial infarction in man, PVT was most common
      during sinus rates generally thought to be within the normal range (60 to 100
      beats/min). A lower, but close to equal incidence of PVT was observed during
      sinus bradycardia and sinus tachycardia.

PMID- 1020753
TI  - Role of circulatory congestion in the cardiorespiratory failure of obesity.
AB  - The role of circulatory congestion in the cardiorespiratory dysfunction of
      massive obesity was investigated in 18 patients. They were hypervolemic and had
      increased cardiac outputs proportionate to their weight. The average resting left
      ventricular filling pressure was within the upper limits of normal, but it
      increased to abnormally high levels with increased venous return of passive leg
      raising, and further during exercise. The elevations in pressure were associated
      with high resting central blood volumes which increased significantly with
      exertion. These findings are consistent with reduced distensibility of the
      central circulation in these congested patients. Weight reduction was accompanied
      by a decrease in central blood volumes and restoration of a normal left
      ventricular response in three of four patients and a return toward normal in one.
      The improvement in ventricular function with relief of edema and dyspnea. In 14
      patients with normal or only minimal alveolar hypoventilation, there were no
      significant transpulmonary diastolic pressure gradients despite a marked increase
      in left ventricular end-diastolic pressures. One patient, after regaining weight,
      subsequently had an abnormal gas exchange and an increased pulmonary vascular
      resistance. He and two others with severe alveolar hypoventilation demonstrated
      cor pulmonale on a background of left ventricular dysfunction and congestion of
      the circulation. Two other patients, the least obese of the group, had
      hypoventilation and cor pulmonale with normal left ventricular pressures.
      Hypervolemia and a hyperdynamic state are common features of the obese patients.
      High cardiac output is maintained despite marked circulatory congestion which may
      result in generalized anasarca and increased ventricular filling pressures. This
      clinical syndrome may be present in obese patients without intrinsic heart
      disease and may be reversible with weight reduction. The central circulatory
      congestion may contribute to the development of the alveolar hypoventilation
      syndrome in certain obese patients.

PMID- 1020754
TI  - Clinical and physiologic studies of two siblings with prekallikrein (Fletcher
      factor) deficiency.
AB  - Two siblings with hereditary Fletcher factor (prekallikrein) deficiency were
      studied for alterations of fibrinolysis, platelet function, skin inflammatory
      responses, permeability factor (PF/dil) formation and leukocyte chemotaxis. In
      vivo stimulation of fibrinolytic activity was normal; the bleeding time and
      platelet functions (adhesivity, aggregation, release reaction) were also normal.
      Both immediate (wheal-flare reaction to histamine, bradykinin, prostaglandin E1,
      physical agents) and delayed sensitivity skin test reactions were within normal
      limits. Migration of subjects' leukocytes to attractants in skin windows and in
      Boyden-type chambers was the same as that of control leukocytes. Serum complement
      components were essentially normal. One subject's leukocytes showed normal tissue
      factor production on stimulation by endotoxin, although prekallikrein deficiency
      did impair the endotoxin-stimulated generation of serum procoagulant activity.
      PF/dil caused increased vessel permeability in human skin; in vitro generation of
      PF/dil required both the Hageman factor and prekallikrein. The Fletcher factor
      deficient subjects responded in a normal manner to PF/dil. Based on the Fletcher
      factor-coagulation assay, the biologic half-disappearance time of prekallikrein
      (after the transfusion of normal plasma in one of the subjects) was estimated at
      35 hours. Therefore, these studies suggest that severe prekallikrein (Fletcher
      factor) deficiency in man is not associated with any clinically significant
      impairment in hemostasis, fibrinolysis, inflammatory responses or leukocyte
      function.

PMID- 1020755
TI  - Hereditary nephritis, deafness and abnormal thrombopoiesis. Study of a new
      kindred.
AB  - A fourth kindred displaying the triad of hereditary nephritis, deafness and
      thrombocytopenia with giant platelets is described. Renal involvement, a common
      cause of death amongst afflicted subjects, appears to have a better prognosis in
      the affected members of this family. Although the electron microscopic appearance
      of the megakaryocytes in the present case appears similar to that in previously
      reported cases, we suggest that the "giant" platelets may result from a
      degenerative process of megakaryocytes leading to nuclear regression and
      cytoplasmic fragmentation, rather than the usual blebbing process.

PMID- 1020756
TI  - Obstructive jaundice in a patient with epidermoid carcinoma of the hypopharynx.

PMID- 1020757
TI  - Pseudocholelithiasis in an elderly man with calcified hydatid cysts.
AB  - A 69 year old man with intrabiliary rupture of a calcified echinococcal cyst
      mimicking acute cholelithiasis is discussed. This case is of interest because the
      correct diagnosis was not recognized preoperatively despite the fact that certain
      aspects of the illness were classic features of this complication of hydatid
      disease. Although this is a common complication of hydatid disease, which is well
      recognized in other countries, only seven cases have been reported in the
      American literature. Treatment of our patient included successful use of a Roux
      en-Y drainage procedure which, to the best of our knowledge, has not previously
      been employed in treating this disease.

PMID- 1020758
TI  - Intravenous injection of talc-containing drugs intended for oral use. A cause of
      pulmonary granulomatosis and pulmonary hypertension.
AB  - Clinical and morphologic features are described in two patients known to have
      repeatedly injected intravenously talc-containing drugs intended for oral use. In
      one patient severe pulmonary hypertension developed; the talc granulomas in him
      were located predominantly within the pulmonary arteries. The second patient had
      normal pulmonary arterial pressures, and the talc granulomas in him were located
      predominantly in the pulmonary interstitium. Of 19 previously described patients
      with pulmonary talc granulomas, 12 had morphologic evidence of pulmonary
      hypertension (in three of severe degree); in each, talc granulomas were located
      predominantly within the pulmonary arteries. In those without signs of pulmonary
      hypertension, granulomas were located predominantly in the pulmonary
      interstitium. Why there are differences in the distribution of the talc
      granulomas is unclear. It is clear, however, as demonstrated by one of our
      patients, that severe pulmonary hypertension may be a consequence of intravenous
      injection of drugs intended for oral use.

PMID- 1020759
TI  - Acute coagulopathy following infusion of prothrombin complex concentrate.
AB  - An acute coagulopathy developed in a 49 year old woman with severe liver disease
      after she received an infusion of prothrombin complex concentrate. The
      concentrate used in the infusion was subsequently studied by observing the effect
      of the concentrate on the partial thromboplastin times of various plasmas. The
      evidence suggests that activated coagulation factors, including activated factor
      X, were present in the concentrate, and probably played a role in initiating the
      acute change in the patient's coagulation status. Mechanisms whereby liver
      disease predisposes toward the development of such a coagulopathy are discussed.
      It would appear that prothrombin complex concentrates should be used in patients
      with liver disease only with utmost caution.

PMID- 1020760
TI  - The liver in hereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease).
AB  - The livers of four patients with hereditary hemorrhagic telangiectasia--including
      the original case of Osler--were examined at autopsy. Characteristic random focal
      fibrovascular lesions were found in all. The importance of recognizing the
      apparently common and seemingly benign hepatic involvement in this disease is
      emphasized in view of its possible confusion with more serious types of liver
      disease that may complicate the condition.

PMID- 1020761
TI  - Angiotensin blockade: its clinical significance.
AB  - An understanding of the possible role of excessive angiotensin II activity in the
      pathogenesis of hypertension in every patient is therapeutically desirable, but
      it is frustrated by the lack of complete reliability of peripheral plasma
      measurements of renin activity. Observation of a clear-cut, supranormal decrease
      in blood pressure during the intravenous infusion of the angiotensin II
      antagonist, saralasin, has provided a far more reliable indication of the
      presence of an angiotensinogenic component in the hypertension. There is
      convincing evidence, however, that the presence of sodium-overload may prevent a
      decrease in blood pressure during saralasin infusion in persons known to have
      angiotensinogenic hypertension and that saralasin may cause a slight decrease in
      the blood pressure of normal subjects after natriuresis. For these reasons, it is
      important to study hypotensive responses to saralasin under standardized
      conditions after the administration of a potent diuretic and to compare the
      observations with those made on normal subjects under identical circumstances.
      This angiotensin antagonist may be used in the therapy of malignant or advanced
      hypertension and as an aid to therapeutic decisions in hypertensive patients who
      have known renal diseases, are taking oral contraceptives or have had severe
      trauma to the area of the kidneys. Side effects of saralasin are limited to
      excessive falls in blood pressure levels, mainly when vasodilators or
      ganglioplegic drugs are being taken at the time of the saralasin infusion, and
      excessive rises in blood pressure levels, especially in hypertensive subjects
      with "low renin" activity during high rates of saralasin infusion or after
      intravenous injections of large boluses. This safe and reliable drug is a
      valuable tool in the investigation and therapy of hypertension.

PMID- 1020762
TI  - Usefulness and limitations of saralasin, a partial competitive agonist of
      angioten II, for evaluating the renin and sodium factors in hypertensive
      patients.
AB  - Saralasin was infused into 52 untreated hypertensive patients. Immediate,
      transient pressor responses occurred in 94 per cent followed by a more gradual
      sustained change in blood pressure reaching an apogee in about 20 minutes. Most
      (86 per cent) patients with high renin values had sustained depressor responses
      irrespective of sodium balance. In contrast, during a normal sodium intake, the
      drug produced a neutral (45 per cent) or mildly pressor (50 per cent) response in
      patients with normal renin and pressor responses in patients with low renin
      values. Sodium depletion abolished pressor responses and resulted in depressor
      responses in 64 per cent of the patients with normal renin values. The
      pretreatment angiotensin level appeared to determine direction and amplitude of
      the response to saralasin, since increases and decreases in diastolic pressure
      exhibited a highly significant relationship to the control renin lever (r = 0.80,
      p less than 0.001). Above a neutral range of control renin values, from 2 to 7 ng
      Al/ml/hour, depressor responses were the rule, and below it pressor responses
      were consistent. Sodium balance also appeared to determine the amplitude of the
      response. In a subset of patients with similar renin values (range 1.4 to 2.2
      ngAl/ml/hour), the induced pressor responses correlated directly with the 24-hour
      sodium excretion (p less than 0.05). For all patients, the induced pressure
      change also was related to the rate of sodium excretion (r = 0.53, p less than
      0.001). The data suggest that saralasin behaves as a partial competitive agonist
      of angiotensin II. For this reason, saralasin testing provided only a rough
      physiologic validation for renin profiling. Thus, depressor responses expose most
      patients with high renin values. Neutral responses occur in many patients with
      normal renin and intermediate renin values. But pressor responses occur in
      subjects with either low or normal renin levels and they may reflect sodium and
      volume excess associated with a partial or relative absence of renin.
      Accordingly, due to its partial agonism, saralasin testing under-estimates the
      renin factor. Hence, the drug cannot be used to identify or exclude renin
      involvement in the blood pressure in the large majority of hypertensive patients
      who do not exhibit depressor responses. For them an agent devoid of agonism is
      required. Moreover, prior sodium depletion as a device to increase the frequency
      of depressor responses to saralasin does not measure intrinsic renin dependency
      of the blood pressure but rather the reactivity of the system to sodium
      depletion.

PMID- 1020763
TI  - A precedence effect in the processing of verbal information.
AB  - When a brief sound is monitored in a sound-reverberating room, it is immediately
      followed by numerous echoes bounced off the walls and ceiling. Only the first
      sound to arrive at the ears appears to be used in its localization. This is
      generally referred to as the precedence effect. If the processing of verbal
      information is seen as a reverberating system (after Hebb) and rehearsal as the
      manifestation of the echoes, then an analogous precedence effect can be
      empirically demonstrated. Such an analogy not only helps explain previously
      uninterpretable data but also generates a very unique prediction that was
      confirmed by experimental data. The theoretical implications of the analogy are
      also discussed.

PMID- 1020764
TI  - Finding the relevant attribute of visual or auditory stimuli.
AB  - The stimuli in a simple attribute-identification task were geometric designs or
      their verbal descriptions. Presentation was visual or auditory, in a constant
      order or a mixed order that varied the serial position of the relevant dimension
      (the dimension providing the relevant attribute) on each trial. Constant-auditory
      problems whose relevant dimensions were first or last were solved better, while
      mixed-auditory problems were solved least well, and visual problems were solved
      best overall with no serial-position effects. However, the results of an
      experiment in which the stimuli were noun pairs suggest that visual presentation
      is advantageous only if it produces a nonverbal code from which subjects can
      recover attributes lost from their descriptions during rehearsal.

PMID- 1020765
TI  - The effects of visible eye and head turn on the perception of being looked at.
AB  - When a model turns her head and looks directly at the lens of a camera, the
      perception of being looked at depends on which eye of the model is observed. The
      model's farther eye appears to be looking at the observer, while her nearer eye
      appears to be looking away in a direction opposite to her head turn. Photographs
      of two female models were viewed by 40 adult observers.

PMID- 1020766
TI  - The extraction of information from visual persistence.
AB  - Seven-letter targets were flashed for 50 msec and followed by either a blank
      adapting field (persisting representation of the stimulus fully available) or a
      series of continuous cycles of target and mask until the cumulative duration of
      the target matched the estimated duration of visual persistence (stimulus
      physically present for same interval as representation). The reportability of
      information from the targets in the latter case was only 50% that in the former.
      The interpretation is that visual persistence is an active, continuously
      operating process rather than a passive neural copy of the stimulus.

PMID- 1020767
TI  - Prospective and retrospective judgments of time as a function of amount of
      information processed.
AB  - The subjects, 120 college students, sorted cards for 42 sec with instructions to
      process 0, 1, or 2 bits of information per card (response uncertainty) and then
      were asked to make an absolute judgement of the interval's duration. Half of the
      subjects knew this judgement would be required before the interval (prospective
      paradigm); half did not (retrospective paradigm). Judged time was an inverse
      linear function of response uncertainty under the prospective paradigm, whereas
      no significant function was obtained under the retrospective paradigm.

PMID- 1020768
TI  - The 'golden rectangle': some new data.
AB  - From two different series of dimensions were generated six ranges of nine
      rectangles each. Each range was presented to a different group of 15 men and 15
      women, and a novel measure was used to assess aesthetic preference for each
      rectangle. The ratios between the lengths of the sides of the rectangles were the
      same in both series, but in one series the size of the rectangles covaried with
      the ratio between length and width, as in Godkewitsch's 1974 study, and in the
      other series the rectangles were of equal area. The subjects tended to prefer
      large to small rectangles in the former series and rectangles in the vicinity of
      the 'golden section' in the latter.

PMID- 1020769
TI  - [Determination of the sex of the fetus by studying Y-chromatin in the blood and
      cervical mucus of the mother].

PMID- 1020770
TI  - [Genetic studies of married couples with children having developmental defects].

PMID- 1020771
TI  - [Importance of medical genetic studies for the prevention of perinatal pathology
      caused by sex-linked inherited diseases].

PMID- 1020772
TI  - [Chromosome anomalies and miscarriage].

PMID- 1020773
TI  - [Principles of medical genetic consultation in spontaneous abortions in women].

PMID- 1020774
TI  - [Development of endocrine integration in the prenatal period of human
      development].

PMID- 1020775
TI  - [Effect of induced (artificial) abortion on the secondary sex ratio in man].

PMID- 1020776
TI  - [Clinical aspects and the differential diagnosis of some congenital defects of
      sexual development in the female phenotype].

PMID- 1020777
TI  - [Medical genetic consultation in cyclopia].

PMID- 1020778
TI  - [Obstetrical problems of phenylketonuria].

PMID- 1020779
TI  - [Effect of the conditions of intrauterine development on the maturation of the
      alveolar structures in the fetus].

PMID- 1020780
TI  - [Inhibitory action of sex hormones on the uterotropic effects of prostaglandin
      F2alpha].

PMID- 1020781
TI  - [Dermatoglyphic studies in obstetrical and gynecological practice].

PMID- 1020782
TI  - [Estrogen receptors in the normal and pathological uterine tissue of women].

PMID- 1020783
TI  - [Relationship of the changes in the capillary network and neural elements of the
      myometrium to the sizes of the tumorous nodes in uterine fibromyoma].

PMID- 1020784
TI  - [Analysis of the statistical patterns of uterine electrical activity in gonadal
      pathology].

PMID- 1020785
TI  - [Characteristics of blood volume disorders in uterine myoma].

PMID- 1020786
TI  - [Evaluation of the functional state of the uterus and uterine tubes in uterine
      myoma using x-ray television metrosalpingography].

PMID- 1020787
TI  - [Rehabilitation of reproductive function in women having undergone conservative
      myomectomy].

PMID- 1020788
TI  - [Gonadotropins and growth hormone in hyperplastic processes and cancer of the
      endometrium].

PMID- 1020789
TI  - [Treatment of chronic nonspecific endometritis].

PMID- 1020790
TI  - [Menstrual function in girls who have undergone ovarian surgery at puberty].

PMID- 1020791
TI  - [Sclerocystic changes of the ovaries in girls].

PMID- 1020792
TI  - [Use of prednisolone, chorionic gonadotropin and infecundin for the differential
      diagnosis of sclerocystic ovaries].

PMID- 1020793
TI  - [Characteristics of the metabolic processes in the myometrium studied in tissue
      culture].

PMID- 1020794
TI  - [Experimental and clinical studies of the mechanism of the hemostatic effect of
      local hypothermia in gynecological operations].

PMID- 1020795
TI  - [Experience in organizing a specialized endocrinologic gynecological service in a
      provincial hospital system].

PMID- 1020796
TI  - [Pathogenesis of ureteral obstruction after radiotherapy of cervical cancer].

PMID- 1020797
TI  - [Diagnosis and treatment of ureteral-vaginal fistulae].

PMID- 1020798
TI  - [Possibility of pregnancy after surgical sterilization].

PMID- 1020799
TI  - [Iodine metabolism in genital endometriosis treated with infecundin].

PMID- 1020800
TI  - [Examination for gonorrhea and trichomoniosis of women with inflammatory diseases
      of the urogenital system].

PMID- 1020801
TI  - [Torsion of the uterine tube and hemorrhage into the ovary in a 6-year-old girl].

PMID- 1020802
TI  - [Our experience with treating juvenile hemorrhages].

PMID- 1020803
TI  - [Characteristics of the one-step method of colpopoiesis using the pelvic
      peritoneum and the management of the postoperative period].

PMID- 1020804
TI  - [A case of nasopharyngeal fibroma treated by means of embolization and surgery].

PMID- 1020805
TI  - [Cervical lymphatic emptying].

PMID- 1020806
TI  - [Diagnostic value of sodium pertechnetate in salivary gland diseases].

PMID- 1020807
TI  - [Ultrastructural aspects of the semicircular canal of Menieres vertigo].

PMID- 1020808
TI  - [Statics, growth and functional adaptation].

PMID- 1020809
TI  - Cardiac innnervation in the prenatal stages of Anas poecilorhyncha.
AB  - Innervation of the heart has been observed in the progressive developmental
      stages of Anas poecilorhyncha ranging from 8 h to 14 days stages using silver
      impregnation technique of Ungewitter (1951). Vagal cardiac fibres reach the
      atrial wall on the fourth day. Migration of nerve cells and ganglia has been
      observed from the more anterior regions to the heart along the precaval veins.
      The adult pattern of the heart is first established at the 8 days stage while the
      traces of the endocardial cushions are still present. The atrioventricular valves
      show rich innervation. The subepicardial ganglia and simple myocardial plexuses
      appear in the 8 days stage and become well differentiated on the 10th day. The
      subendocardial plexuses are reported to be sensory for the testing of the
      properties of the blood while the myocardial plexuses seem to have motor control
      over the working muscles of the heart specially those of the atria where rich
      innervation is observed. Local reflex areas have been described.

PMID- 1020810
TI  - [Measurement of joint flexibility].

PMID- 1020811
TI  - [The blood supply of the knee joint carilage in humans].

PMID- 1020812
TI  - Histomorphological study of adrenal gland in three ophidian species.
AB  - Adrenal gland is studied histologically in the common krait, the cobra and the
      viper. It is comprised largely of cortical tissue with medulla. Chromaffin tissue
      is spatially distributed on dorsal surface and in the intercortical area of the
      adrenal gland. Percentage of dorsal chromaffin is higher in the viper and cobra
      than that of the krait, while that of intercoritcal chromaffin is higher in the
      krait than that of others. Chromaffin cells are irregular, smaller with densely
      granulated cytoplasm and larger nuclei than those of interenal gland. Medullary
      cells are larger in the cobra than those of other snakes. Cytomorphological
      difference between the dorsal and intercortical chromaffin is marked only in the
      cobra. Occurrence of larger granules in the dorsal and smaller type in the
      intercortical chromaffin may be related with noradrenaline and adrenaline
      secretion respectively. Cortical percent is higher in the krait than that of
      other snakes. Adrenocortical zonation is found only in the common krait and
      cobra. Subcapsular zone shows regular cords with radial disposition of columner
      cells in contrast to the irregular orientation of polygonal cells noted in the
      central cortex. Differences observed in general morphology and histology of
      adrenal gland, are possibly due to species difference.

PMID- 1020813
TI  - [The development of the Paneth cell population in the rat].

PMID- 1020814
TI  - Variation in basal arteries of the brain in polecat (Mustela putorius putorius
      L.).
AB  - Observations carried out on 106 polecat brains showed that the system of basilar
      arteries of the brain is similar to those in other cornivorous species. The
      observed variation was manifested in a differentiation connections of the
      vessels, in occurence of some variations and in asymmetry. Some cases of such
      variations were hitherto observed only in some ruminants.

PMID- 1020815
TI  - The effect of testosterone, progesterone and orchidectomy on the kidney of common
      ground squirrel, Funambulus pennanti.
AB  - Histological changes, caused by testosterone, progesterone and castration in the
      kidney of common ground squirrel, Funambulus pennanti have been described in this
      report. It is concluded that kidney is no doubt an endocrine receptor but behaves
      specifically to androgens as well as estrogens giving dis-similar results. The
      extent of toxicity has been measured with the help of histoenzymological
      reactions previously made. Prolonged administration of androgens and estrogens to
      patients in clinical practice is warned. It is a must firstly to determine the
      dose which is well tolerated by healthy subjects. These safe levels should not be
      exceeded under any circumstances.

PMID- 1020816
TI  - [Lipoma of the adrenal cortex].

PMID- 1020817
TI  - [Asymmetry of the human body].

PMID- 1020818
TI  - [Leukocyte system during the peri-operative period in patients operated on under
      various forms of general anesthesia].

PMID- 1020819
TI  - [Clinical evaluation of the Undofen aerosol preparation manufactured by Polfa].

PMID- 1020820
TI  - [Penicillin allergy and reactivity to other antigens].

PMID- 1020821
TI  - [Remote results of treating acromegaly by surgical and conservative methods].

PMID- 1020822
TI  - [Achondroplastic dwarfism].

PMID- 1020823
TI  - Simulation of ocular dysmetria using a sampled-data model of the human saccadic
      system.

PMID- 1020824
TI  - Sensitivity and afterload independence of zero-load aortic flow.

PMID- 1020825
TI  - Principles of the design and operation of generic osmotic pumps for the delivery
      of semisolid or liquid drug formulations.

PMID- 1020826
TI  - Forces on lumbo-vertebral facets.

PMID- 1020827
TI  - On the variation of heart dipole moment with body size.

PMID- 1020828
TI  - [Common denomination of the active principles contained in drugs].

PMID- 1020829
TI  - [Indications for arteriography and determination of parathyroid hormone in staged
      venous samplings in primary hyperparathyroidism].
AB  - The information provided by parathyroid arterigraphy and staged venous sampling
      with parathormone estimation is essentially related to localisation and is of
      little diagnostic value. It is not justifiable on a routine basis before all
      operations. These techniques are particularly useful in patients with practically
      definite hyperparathyroidism and who have already undergone a negative
      exploratory operation or surgery with insufficient excision.

PMID- 1020830
TI  - [Positive toxoplasmic serology in polymyositis].

PMID- 1020831
TI  - [Superacute amebic rectocolitis. Clinical and therapeutic remarks].

PMID- 1020832
TI  - [A case of Mollaret's recurrent benign endothelio-leukocytic meningitis].

PMID- 1020833
TI  - [Tuberculous osteitis of the cranial vault].

PMID- 1020834
TI  - [Hemodynamic study of gas exchange in pulmonary edema caused by bacterial lung
      diseases].

PMID- 1020835
TI  - [Pemphigus, myasthenia and thymoma].

PMID- 1020837
TI  - [Remarks on the study of the status of the mental patient in France from 1953 to
      1976].

PMID- 1020836
TI  - [Characteristics of psychiatric day care units: a tentative clarification].
AB  - For more than 20 years now, an important literature has informed us of the
      advantages and disadvantages of Day Units, but sometimes in a way which is not
      always impartial. In the same view the delimitation of the aspects of Day Units
      and the appreciation of their great field of application are sometimes not all
      that clear. These component units associated with the conservative outlook of
      health politic planners and the majority of psychiatrists are promoting factors
      for the use of psychiatric hospitalizations instead of the use of Day Units and
      Out-patient facilities on the whole. In this paper, we will start by outlining
      the frame of the "Day Unit", in its specificity in regard to full time
      hospitalizations and other modes of psychiatric assistance. We would like to
      point out the extreme diversity of Day Units according to the type of patients
      treated, the age, the aims of the institution, the connections with other
      psychiatric units, the modality of admission etc. Following this, we will try to
      show what the intrinsic characteristics of Day Units are, especially in comparing
      them to those of full time hospitalizations; treatment during the day, reduced
      costs, greater feeling of the outside world, greater automony of the patient,
      less accent on the fear of madness, less humiliation, reduced fear of psychiatric
      institutions. Using these intrinsic characteristics, we have tried to define the
      potential characteristics which are derived directly from the above, but which,
      to be fully developed, implicate a therapeutic option: better quality of team
      work, facility for the use of non-directive psychotherapies, prevalence of psycho
      medical treatments and sociotherapeutic treatments over the administrative and
      bureaucratic orders. Finally, we point out that many characteristics of the Day
      Units, often called intrinsic or potential, issue from conjunctural factors such
      as the small size of the unit, the convenient geographical situation, the
      facility for utilization of new therapeutic technics etc. The development of the
      Day Unit movement was able to profit from the ongoing critic of the usual
      psychiatric hospital practices and experiences. We do hope that this paper will
      help to make clear the frame, the different way of application and particularly
      the characteristics of Day Units which deserve to be well known, well utilized,
      so that the different psychatric facilities will be able to profit from their use
      and through this, all those for whom we are asked to care for.

PMID- 1020838
TI  - [The medico-legal status of drug addicts: repression or treatment?].

PMID- 1020839
TI  - [Can the decline of catatonia be considered as an index of the changing status of
      mental patients in France?].

PMID- 1020840
TI  - [The occupational rehabilitation center: asylum or anti-asylum?].

PMID- 1020841
TI  - [Status of the mental patient in 1976 in a psychiatric department of a general
      hospital].

PMID- 1020842
TI  - [The psychiatric infirmary of the prefect of police].

PMID- 1020843
TI  - [Various aspects of daily life of psychotics in partial hospitalization (the
      condition of psychotics presently treated by day care].

PMID- 1020844
TI  - [Bilingualism].

PMID- 1020845
TI  - [Analysis of destiny in psychiatry and psychotherapy. I. Correlations with
      clinical diagnosis].

PMID- 1020846
TI  - [Factors influencing mental health in Greece].

PMID- 1020847
TI  - [The Greek family and its influence on the genesis and evolution of mental
      disease].

PMID- 1020848
TI  - [Ideas for future decentralization of psychiatric care system in northern
      Greece].

PMID- 1020849
TI  - [Development of the civil status of the mental patient in Greek and French law].

PMID- 1020850
TI  - [Conceptual validation of a psychiatric syndrome classification].
AB  - The authors present the first results of an investigation concerning the
      conceptual validity of a phenomenological classification of psychiatric patients.
      Conceptual stereotypes for 8 syndromes, derived from applications of cluster
      analysis and related numerical taxonomy methods to BPRS symptom rating profiles,
      were obtained by 33 experienced French psychiatrists. Analysis of the profile
      data reveal that the names chosen to describe the empirical prototypes elicit 8
      clearly differenciated syndromes and that the experts' understanding of the
      nomenclature is highly consistent. Problems concerning the relationship between
      two of the empirical prototypes and the corresponding conceptual stereotypes are
      discussed.

PMID- 1020851
TI  - [I. A mirror to reflect].
AB  - To explain the specular permutation of the right and the left an adult subject
      has recourse continually to expression--image. An elementary optical study
      demonstrates that explanation leads to metamorphose the flat-mirror in a lentil.
      In fact the operation truth-fully realized by the mirror is an antero-posterior
      rotation of subject causing necessary but secondary a couple right left rotation.
      The unvariance of this behaviour and these false answers authorizes to represent
      the mirror like an operator motiving the subject's identity without we understand
      the utmost reason. A second memory will thy to give an explanation of that fact
      to start from a symbiosis between the breuero-freudian theories and the piagetian
      concept.

PMID- 1020852
TI  - [Analyses of various "elementary" psychological phenomena in man].

PMID- 1020853
TI  - [Man and the spectacle. Notes on the psychologic reactions of the spectator].
AB  - The comprehension of the spectator's psychology is difficult because of the fact
      that one should first analyse what is peculiar to the spectacle's creator. Louis
      Ferdinand Celine presents the advantage to be at the same time an ingenious
      litterary creator and a ballets' passionate spectator. The author's purpose
      consists in demonstrating that the writer's interest in ballets is determined by
      the fight against death's anxiety, which is present in his whole work. On the
      basis of the freudian notions of "Vorlust" and "Endlust" he comes to the
      conclusion that the "compensatories" phantasies which are composing the new
      reality proposed by the creator rejoin the spectator's desirs which vary
      nevertheless from one person to another.

PMID- 1020854
TI  - [Death, psychosis and obsession. Statistical study].

PMID- 1020855
TI  - [Outcome and elements of prognosis in mental anorexia (apropos of 44 cases)].

PMID- 1020856
TI  - [Oedipal gout].

PMID- 1020857
TI  - [Hysterical syndrome masking the signs of onset of an intracranial hemorrhage
      caused by an angioma].

PMID- 1020858
TI  - [Remarks on the practical application of the law of January 1968 on "major
      incompetents"].

PMID- 1020859
TI  - [Use in psychiatry of antiparkinson drugs].

PMID- 1020860
TI  - [Psychiatric effects of cardiac surgery].
AB  - The authors report three cases of psychotic complications of cardiac surgery. A
      review is made from literature and an inventory of psychological and organic
      factors implicated in this pathology. These complications are still frequent (up
      to 50% for Braceland, and 70% for Rabiner and al.). For Blacher there is an
      almost universal "psychosis" in by-pass surgery and frequent "hidden psychosis"
      (they are ignored and denied both by the staff and the patient). They are caused
      by the emotional stress, intensive care unit syndrome, or personal vulnerability.
      The symbolism of the heart and the personality of the cardiac patient are also in
      cause. Neurologic accidents, hypoxy, embolisms, are now less frequent. The
      collaboration of a psychiatrist with the cardiologic staff is mandatory. With
      this collaboration not only psychiatric complications but also somatic morbidity
      and mortality would be reduced.

PMID- 1020861
TI  - [Reality approach in senile dementia. Fundamental methodologies of occupational
      therapy in psychogeriatrics].
AB  - Occupational therapy in psychogeriatrics has always been practiced empirically,
      aimed mainly at merely occupying patients. In the light of recent findings from
      the old age psychological research, a specific method should cope with certain
      forms of lost intellectual capacities. The purpose of this work is to define as
      accurately as possible the field of occupational therapy in psychogeriatrics.
      Three main concepts towards a systematic approach can be proposed: a) Those
      related to a careful observation of spontaneous activities dealing with the
      relationship between the patient and the world around him, and which lead to a
      classification of these activities. b) Concepts related to the most elementary
      level of intervention in occupational therapy termed as "objective relationship",
      in other words the construction of the external objective world as opposed to the
      world of phantasms or magical thought. c) Concepts, at a more sophisticated
      level, related to the instrumental aspects of traditional occupational therapy.
      An important distinction should thus be made between local and inclusive
      constituent parts of an activity.

PMID- 1020862
TI  - [Remarks on the action of Moditen-retard and Modecate. Apropos of 65 cases].

PMID- 1020863
TI  - [Genetic study of schizophrenia: discussion of several models of genetic factors
      of transmission (from genetic analysis of 25 pedigrees)].

PMID- 1020864
TI  - [Antagonism between anti-Parkinson drugs and neuroleptics. Apropos of various
      withdrawal experiences, a personal one among them (2nd part)].

PMID- 1020865
TI  - [Description of a simple graphic model permitting the comparison of the course of
      depressive states].

PMID- 1020866
TI  - [Alcoholism and depression. Statistical survey on familial antecedents of
      depression and alcoholism in a series of alcoholic men and depressed women].

PMID- 1020867
TI  - [Case reports of language disorders in schizophrenia. Critique of the notion of
      schizophrenia].

PMID- 1020868
TI  - [Instability of group FII plasmids in "Salmonella panama" (author's transl)].
AB  - Almost all Salmonella panama isolated in France only harbour R plasmids of
      incompatibility groups I1 (K Col Ib) and N (T). Reference R plasmids belonging to
      11 incompatibility groups have been introduced into S. panama. All are stable
      after 50 generations except those of group FII. FII instability cannot be
      explained either by the presence of a group FII cryptic plasmid or by restriction
      enzymes in S. panama.

PMID- 1020869
TI  - [Supplement No XIX to Kauffmann-White scheme (author's transl)].
AB  - In that supplement are given the characters of new Salmonella serotypes
      recognized in 1975 by WHO collaborating Centre for reference and research on
      Salmonella. Twenty-six belong to the sub-genus I, 10 to the sub-genus II, 9 to
      the sub-genus III and 1 to the sub-genus IV. A new H antigen phase 1(g,Z62) has
      been approved. Biochemical and antigenic variants of already known serotypes are
      described.

PMID- 1020870
TI  - [Vaccinations against rabies in France in 1975].

PMID- 1020871
TI  - [Taxonomic study of enterobacteria belonging or related to the genus Enterobacter
      (author's transl)].
AB  - The classification of 175 strains related to the genus Enterobacter has been
      carried out by numerical procedure, with usual biochemical and nutritional
      characters as shown by the utilization of substrates tested as sole sources of
      carbon and energy. The taxonomic position of the strains is discussed in relation
      to the species E. cloacae, E. hafniae, E. aerogenes, E. agglomerans and Serratia
      liquefaciens. By the system of data analysis used (hierarchical agregation
      method) five principal classes can be defined. The individualization of new
      classes closely bound to the diverse origins of the strains examined (human,
      soil, aquatic).

PMID- 1020872
TI  - [A new, sporulating, denitrifying, mesophilic bacterium: Bacillus azotoformans N.
      SP. (author's transl)].
AB  - The described bacterium was isolated by enrichment culture in peptone broth
      inoculated with garden soil, pasteurized and then put to incubate under N2O at 32
      degrees. It is a Gram-negative rod, motile with peritrichous flagella, and
      producing oval spores without exosporium in swollen sporangia. However, cells
      have the thick walls, mesosomes and persistant septa characteristic of Gram
      positive bacteria. It lacks fermentative activity, does not attack carbohydrates,
      has complex growth requirements, and will grow anaerobically only if one of the
      following electron acceptors is present: NO3, NO2, N2O, S4O6, and fumarate.
      Nitrate, nitrite, and nitrous oxide are denitrified with production of N2. The
      microorganism is mesophilic, gives a positive oxidase reaction, synthesizes a
      type of c cytochrome, and does not hydrolyse gelatin, starch nor "Tween 80". The
      following enzymes are present: nitrate reductase A, respiratory nitrite
      reductase, tetrathionate and fumarate reductases, L-glutamate dehydrogenase, and
      superoxide dismutase. The following enzymes are absent: thiosulfate reductase,
      urease, lecithinase, arginine dihydrolase, L-alanine dehydrogenase, phenylalanine
      desaminase, and catalase. The GC% of its DNA is 39. The bacterium described can
      be considered to be a new species. We propose the name Bacillus azotoformans n.
      sp.

PMID- 1020873
TI  - [Isolation and characterization of two strains of Streptomyces able to metabolize
      natural polysaccharides including mannan (author's transl)].
AB  - Two strains of aerobic and mesophilic microorganisms were isolated from palm-tree
      plantation sand. They grew on insoluble polysaccharides: mannan, cellulose,
      chitin as only source of carbon. This lytic activity was used for the
      purification of the two strains. The morphology of the organisms and the presence
      of LL-diaminopimetic acid in their cell-wall are characteristic of the genus
      Streptomyces. Investigations lead to: 1) the characterization of their specific
      polysaccharidase activity toward insoluble and natural beta-and alpha-glycans
      (mannan, cellulose, chitin, pectine and starch) and the formation of soluble
      saccharides (mannobiose, cellobiose, beta-D-N-acetylglucosamine, galacturonic
      acid, and maltose); 2) the research for antagonist, or synergic, effect on
      pathogenic bacteria and certain phytopathogenic microorganisms; only in the case
      of these latter was a weak lytic activity exerted by the two Streptomyces
      isolates, but one of them was shown to stimulate Colletotrichum lindemuthianum
      and Phialophora cinerescens; 3) a study of antibiotic sensitivity; the two
      strains were sensitive to tetracycline and streptomycin, but they had native
      resistance to other aminosides (gentamicin, kanamycin), to erythromycin and to
      the beta-lactam antibiotics (penicillin and cephalosporin); they possessed a beta
      lactamase bound to the cell membrane.

PMID- 1020874
TI  - [Isolation and study of a new marine bacterium growing on hydrocarbons. I.
      Physiological study (author's transl)].
AB  - The bacterial strain L.16.1 isolated from coastal waters polluted by oil-waste,
      close to the genus Alcaligenes, utilizes preferentially alkanes with a carbon
      number greater than 9. Sugars and amino-acids cannot serve as carbon source to
      this bacterium. Cells grown on hydrocarbon the chain length of which ranges from
      C10 to C18 exhibit very high yield (98%) with a growth rate of 0.47. From our
      studies it appears that strain L.16.1 is strictly dependent on the presence of
      the Na+ ion and that this Na+ dependence can be seen at each level of the
      physiological activity. Alkane-grown cells show morphological features namely
      disc shaped cytoplasmic vesicles (6-8 per cell). Such vesicles are to be regarded
      as a consequence of the very high lipid content (twice the standard) which
      characterizes these cells. Additional lipids belong essentially to the
      nonsaponifiable fraction (20 times more in hexadecane grown cells); on the
      contrary, the phospholipid content at both qualitative and quantitative points of
      view does not depend on the nature of the growth substrate.

PMID- 1020875
TI  - [Isolation and study of a new marine bacterium growing on hydrocarbons. II.
      Mechanism of lysis and viability (author's transl)].
AB  - The growth of the marine bacterium (L.16.1) is strictly dependent on the presence
      of well-defined NaCl concentrations (100 mM on alkanes and 75 mM on acetate,
      pyruvate or propionate) in the medium. L.16.1 cells undergo lysis on transfer
      from high to low ionic environment. This lytic phenomenon, which can be prevented
      by the presence of Na+ or divalent cations, appears to be due to the loss of Mg++
      and Ca++ by the cells. Evidence for this hypothesis is provided by the assays of
      intracellular and extracellular Na+, K+, Mg++ and Ca++ concentrations. The
      maintenance of the cell integrity of the organism does not depend on the medium
      osmolarity, since osmotic compounds such as sucrose, glycerol or mannitol cannot
      prevent lysis. All of the ions which can maintain the cell integrity are not
      likewise able to keep viability; this has been found to be a function of Na+
      concentration (70% survival after 24 hours in 400 mM NaCl, only 10% in 50 mM
      MgSO4).

PMID- 1020876
TI  - [Isolation and study of a new marine bacterium growing on hydrocarbons. III.
      Oxidation of substrates and effects of detergents on the cells (author's
      transl)].
AB  - The oxidation of exogenous hexadecane by cells of strain L.16.1 is a function of
      intracellular and extracellular Na+ and K+ concentrations. The cells which lost
      their Na+ as a result of washing in the absence of sodium chloride oxidize
      hexadecane at a very low rate. Washings in the absence of Mg++ and Ca++ do not
      result in a similar decrease of the respiratory activity. The latter cannot be
      maintained--or restored after decrease--by the divalent cations which are active
      in preventing cytolysis (see the preceding paper). A possible explanation for
      this Na+ dependence could lie in a particular role played by Na+ inthe
      cytoplasmic membrane and in some function related to the oxidative activities of
      the cell membrane. From other studies carried out with ionic detergents it was
      observed that growth and respiratory activity are inhibited by very low
      concentrations of these compounds contrary to non ionic detergents which can
      serve as growth substrates and are oxidized like hexadecane or acetate. It is
      concluded that the bulk of our results could best be accounted by assuming that
      the membranes of halophilic bacteria are organized according to a specific
      organization scheme.

PMID- 1020877
TI  - [The protective properties in mice of tonate virus and two strains of cabassou
      virus against neurovirulent everglades Venezuelan encephalitis virus (author's
      transl)].
AB  - Venezuelan encephalitis virus is a constant menace to man and to animals,
      particularly horses. Two as yet unreported strains have been isolated in French
      Guyana: Ca An 410d (Tonate) and Ca Ar 508 (Cabassou). They are not neurovirulent
      after peripheral inoculation into adult mice and guinea pigs. Cabassou is not
      pathogenic for adult mice after intracerebral inoculation. A third strain, Ca Ar
      19007, is antigenically identical by complement-fixation with Cabassou, but
      appears to cross react with other strains, Tonate, when injected intra
      peritoneally or sub-cutaneously, protects adult mice against intra-cerebral or
      intra-peritoneal challenge with Everglades virus. The Ca Ar 19007 isolate causes
      total protection against Everglades virus if injected intra-peritoneally, but
      only partial protection by the sub-cutaneous route. Cabassou, on the other hand,
      if injected intra-peritoneally will protect against intra-cerebral challenge with
      Everglades. Tonate and Ca Ar 19007 thus appear to be naturally occurring
      attenuated variants of the Venezuelan encephalitis virus complex, which can
      protect mice against intra-cerebral infection with neurovirulent strains.

PMID- 1020878
TI  - [Sequential treatment in epithelial tumors of the ovary: usefulness of the
      "second look"].

PMID- 1020879
TI  - [Organization ofthe delivery room: the minimum requirements].

PMID- 1020881
TI  - [Range of normality of fetal BPD (biparietal diameter) measured by means of
      ultrasonics].

PMID- 1020882
TI  - [Clinical significance of plasma estriol. 2. its relation to urinary estriol in
      pathologic pregnancies].

PMID- 1020883
TI  - [Biologic properties of amniotic fluid (bibliographic review)].

PMID- 1020884
TI  - [Cesarean section in the Clinica L. Mangiagalli in 1957-1960 and 1972-1975].

PMID- 1020885
TI  - [Induction of labor with oral Pgs E2].

PMID- 1020886
TI  - [Maternal mortality in Lombardy and its causes. Results of a survey conducted in
      the hospital of Lombardy for the years 1966-1973].

PMID- 1020887
TI  - [Anatomo-clinical observations on a case of solitary neurofibroma of the vagina].

PMID- 1020888
TI  - [Vaginal smears in the puerperium].

PMID- 1020889
TI  - The genera Paranoplocephala Luhe 1910 and Anoplocephaloides Baer, 1923 (Cestoda:
      Anoplocephalidae), with particular reference to species in rodents.
AB  - The present study redefines the systematic arrangement and taxonomic status of
      some anoplocephaline cestodes previously allocated among the genera Andrya
      Railliet, 1893. Paranoplacephala Luhe, 1910, and Aprostatandrya Kirshenblat,
      1938. Comparisons indicated that Paranoplocephala omphalodes (Hermann, 1783),
      type species of Paranoplocephala, differs morphologically from its congeners, all
      of which conform to the diagnosis of the genus Anoplocephaloides Baer, 1923,
      hitherto considered a synonym of Paranoplocephala, and that it cannot be
      distinguished at the generic level from Aprostatandrya macrocephala (Douthitt,
      1915), type of the genus Aprostatandrya. The distinction between Andrya and
      Aprostatandrya based on the presence or absence of a "prostate gland" does not
      exist, for neither the type species of Andrya, A; rhopalocephala (Riehm, 1881),
      nor A. cuniculi (Blanchard, 1891) possesses such an organ; rather, the structure
      of the external seminal vesicle in these cestodes does not differ fundamentally
      from that in P. omphalodes or in species of Aprostatandrya. Based on these
      findings, Aprostatandrya Kirshenbalt, 1938 is placed in synonymy with
      Paranoplocephala Luhe, 1910, and Anoplocephaloides Baer, 1923 is restored to
      contain all species other than P. omphalodes formerly allocated to the genus.
      Paranoplocephala. If the pattern of development of the uterus in A.
      rhopalocephala is found to be like that in P. omphalodes, Paranoplocephala Luhe,
      1910 will in turn also become a synonym of Andrya Railliet, 1893. Three
      additional species of Anoplocephaloides are described, and the zoogeography of
      Anoplocephaloides spp. and their mammalian hosts is briefly discussed.

PMID- 1020890
TI  - [The effect of lactation on the parasitism of rats by Strongyloides ratti
      (author's transl)].
AB  - In lactating females of many animal species infested by Nematoda, the self-cure
      is, if not suppressed, at least very distinctly delayed. It does not appear that
      an immunological deficiency is the cause of this. We show that this phenomenon
      also exists in lactating female rats with Strongyloides ratti parasites. In fact,
      for Strongyloides ratti, the maintenance of the worms is not the only notable
      modification determined by lactation; much more important is the decrease in the
      intensity of the parasitism. This aspect is not mentioned by writers who have
      only studied the different parasitic states in their final phase. Parallel to
      these alterations in the parasitism, the evolution of the corticosteronemy
      differs, from two points of view, from that described in infested virgin rats: -
      Suppression of the hypercorticosteronemy which normally appears 48 hours after
      infestation; --Attenuation of the hypocorticosteronemy which usually sets in from
      the tenth day of infestation. This opposition of lactation to the variations in
      the corticosteronemy induced by the worms is explained by the effect of lactation
      on the secretion of gluco-cortico-steroids, described under the term of "buffer
      effect of lactation". The decrease in the intensity of the parasitism may be
      explained by the fact that lactation, by preventing the hypercorticosteronemy
      normally caused by larval migration, permits the intervention of aspecific
      defences. As for the prolongation of the parasitism, it would seem to result on
      one hand, from a reduced solicitation of the means of defence owing to a smaller
      number of worms and, on another hand, from the slowing down of the
      hypocorticosteronemy through the buffer effect of lactation with all the
      consequences flowing from this at the level of the specific and aspecific defence
      reactions.

PMID- 1020891
TI  - [Setaria species from water buffalo of Southeast Asia and from Caffer Buffalo of
      Africa: comparative study with Setaria spp. from cattle of the respective areas
      (author's transl)].
AB  - Setaria leichungwingi Chen, 1937 (stat. nov.), parasite of Bubalus bubalis in
      Asia is closely related to S. labiatopapillosa, but the peribuccal chitinous
      crown is different. Until now, specimens determined as S. labiatopapillosa in
      Africa pertain in fact to two species S. labiatopapillosa sensu stricto and a new
      species described here: S. nelsoni n.sp., characterised by  peribuccal crown's
      form (similated to that of S. leichungwingi) and by narrow host-sepcificity. It
      differs from S. leichungwingi by thick spiny extra-projections in higher
      percentage on peribuccal crown and by fewer spiny formations on the end of the
      female. A table gives the determination of the Setaria from Buffalo of the
      regions between India and East Europe with that from cattle. In the area, Setaria
      sp. from Bubalus is closely related to but different from S. labiatopapillosa.

PMID- 1020892
TI  - [On Setaria spp; (Nematoda, , Filarioidea, Setariidae) from the peritoneal cavity
      of equine spp.: two new sub-species, Setaria equina theilerae from wild Zebra of
      Africa, and Setaria equina dafaallai from horse and donkey of southern Sahara
      area (author's transl)].
AB  - 1) Setaria equina (Abildgaard, 1789) is from the Horse and Donkey of Eurasia (and
      of America and the coastal stripe of North Africa). 2) Setaria equina theilerae
      n.sub.sp. is from the Zebra of Africa. 3) Setaria equina defaallai n.sub. sp. is
      from the Horse and the Donkey of southern Sahara area of the Ethiopean Region of
      Africa, from the Nile valley till to the western coast. 4) Crossing between S.
      equina and S. e. theilerae may be possible, as their host spp. does with the
      resultant bastard offspring experimentally.

PMID- 1020893
TI  - [Presence of Ixodes apronophorus (Schulze, 1924) in France. Ixodoidea--Ixodidae].

PMID- 1020894
TI  - [Study of the binary mixtures, khellin-sulfacetamide and khellin-sulfanilamide,
      by thermomicroscopy, differential thermal analysis, and differential
      calorimetry].

PMID- 1020895
TI  - [Microdetermination of organic bases by atomic absorption. II. Determinations of
      azepines].

PMID- 1020896
TI  - [Preliminary study of the saponins of the fruit of Brenania brieyi de Wild. (13)
      (Rubiaceae)].

PMID- 1020897
TI  - [Synthesis and pharmacologic activity of various 2-phenylamino-3
      pyridinesulfonamides].

PMID- 1020898
TI  - [Etude de l'huile retiree des carpophores de Tricholome pretentieux].

PMID- 1020899
TI  - [Determination of aspirin, phenacetin, and caffeine by UV spectrophotometry].

PMID- 1020900
TI  - Long-term follow-up study of patients operated on for benign peptic ulcer.
AB  - 200 consecutive patients operated on for gastric (GU) or duodenal (DU) ulcer in
      1956 to 1957 were followed up until 1974. 25 of them died within five years of
      primary operation and were excluded to eliminate the possibility of coexisting
      ulcer and malignancy at the time of operation. Four patients could not be traced
      and 65 died within the follow-up period, but none of them of gastric carcinoma.
      46 out of 106 living patients came for re-examination and gastroscopy was
      performed in 42 of them. The remaining 60 patients were examined by
      questionnaire. According to the Finnish Cancer Registry none of them had gastric
      carcinoma. The expected number of gastric carcinomas in the present series was
      calculated to be 2.3 and of all malignancies 13.6, but only one gastric carcinoma
      and 19 other malignancies were detected. The gastric carcinoma detected
      endoscopically and verified bioptically and cytologically was microscopically of
      anaplastic type. Most of the patients were in excellent general condition without
      gastric complaints. The present series reveals no clearcut causal relationship
      between gastric resection and late development of stump carcinoma.

PMID- 1020901
TI  - Hiatal hernia repair.
AB  - 128 patients operated on for hiatal hernia are reported. The follow-up study
      consisted of 102 patients, 16 with paraoesophageal and 86 with axial hiatal
      hernia. The mean follow-up time was 4 1/2 years, range 1-11 years. In our
      experience cineradiographic studies bring abnormalities to light more readily
      because this kind of study is repeatable compared with conventional techniques
      based on fluoroscopy. Four different methods of operation were used in this
      study. The recurrence rate was as follows: Nissen fundoplication 13%, both
      anterior 180 degrees fundoplication and Lortat-Jacobs procedure 38%, and Nissen
      fundoplication combined to vagotomy and pyloroplasty 54%. Postoperative
      complications occurred in 9%. There was no hospital mortality. The authors prefer
      the abdominal to the transthoracic approach because many patients had other intra
      abdominal, surgically easily correctable condition. If the transthoracic
      operation is indicated, as in a very obese patient or in a patient with a
      secondary short oesophagus, intra-abdominal disease must have been excluded
      preoperatively. In the treatment of axial hiatal hernia the best operative method
      has not yet been agreed upon, but in our hands the Nissen fundoplication yielded
      the best results.

PMID- 1020902
TI  - Effect of low-dose heparin on the phagocytic and catabolic function in the
      reticulo-endothelial system in man during surgery.
AB  - The effect of subcutaneous low-dose heparin prophylaxis on the phagocytic and
      catabolic functions of the reticuloendothelial system (RES) was studied in 10
      patients undergoing elective cholecystectomy. The patients were divided into two
      groups; 5 patients receiving 5 000 units of heparin preoperatively and every 12
      hours following the operation and 5 patients given saline at the corresponding
      time. Each patient served as his own control, when the RES function was tested
      twice with microaggregated human serum albumin labelled with 125I as a test
      substance. There was an enhanced phagocytic activity and a correspondingly raised
      catabolic activity of the RES in patients treated with heparin. The reasons for
      this are discussed. The results indicate that heparin in low doses has a
      favourable effect on the RES.

PMID- 1020903
TI  - Lymphatic filling during knee arthrography.
AB  - Six cases of lymphatic filling during knee arthrography have been recorded in
      literature, all of which have had advanced rheumatoid arthritis. We report a case
      of lymph vessel filling from a popliteal cyst in a young male nonrheumatoid
      patient. It is concluded that abnormal synovial-lymphatic connection in the knee
      joint may occur also in other forms of synovial pathology and such a finding does
      not indicate rheumatoid inflammation.

PMID- 1020904
TI  - Cystic adventitial disease--cause of intermittent claudication in male non
      smokers. A case report.
AB  - A case of intermittent claudication in a middle-aged lifelong non-smoker caused
      by cystic adventitial disease is reported. Etiology, clinical and angiographic
      findings, modes of operative treatment, and other possible causes of calf
      claudication in young non-smokers are briefly discussed.

PMID- 1020905
TI  - The effect of segmental epidural analgesia on maternal growth hormone, insulin,
      glucose and free fatty acids during labour.
AB  - The maternal plasma HGH, insulin, glucose and FFA levels were determined during
      the course of induced labours in 28 healthy mothers. Every second patient was
      given segmental epidural analgesia for pain relief during the first stage of
      labour (epidural) group). The others acted as a control group. HGH did not change
      significantly during the labour in either group. Insulin decreased during the
      first stage of labour in both groups. This decrease was more pronounced and
      statistically almost significant in the control group. Thereafter the insulin
      increased in both groups. Glucose levels did not change during the first stage,
      but at the moment of delivery they were significantly higher than the initial
      levels in both groups. FFA levels became raised in both groups during labour,
      reaching a peak at the moment of delivery. The results are discussed in relation
      to stress and effectiveness of pain relief during the first stage of labour.

PMID- 1020906
TI  - Release of fibrinolytic activators from human ovarian tumours in organ culture.
AB  - Malignant human ovarian tumours possess coagulative and fibrinolytic properties,
      reflected in the occurrence of fibrin/fibrinogen degradation products (FDP) in
      the serum or ascitic fluid. The degradation of fibrin/fibrinogen into FDP is
      initiated by activators of fibrinolysis. Using a culture method permitting
      continuous measurement of fibrinolytic activators released, we investigated this
      release in organ culture of 27 various human ovarian tumours and 7 normal
      ovaries. The results showed that ovarian tumour explants released more
      fibrinolytic enzymes than explants from normal ovaries.

PMID- 1020907
TI  - Uretero-vaginal fistula.
AB  - Six cases of uretero-vaginal fistula are presented. Five patients developed this
      complication after gynaecological surgery and one after Caesarian section.
      Constant urinary incontinence combined with normal voiding is typical of this
      lesion. Excretory urography revealed a stricture in the distal part of the ureter
      in 5 cases, while in one patient the urographic findings were normal.
      Accumulation of contrast medium in the vagina was seen on urography in 2
      patients. Surgical correction is the treatment of choice, and all patients were
      successfully treated by resection of the distal part of the ureter with
      reimplantation of the ureter into the bladder.

PMID- 1020908
TI  - [Value of microsurgical treatment of painful neuromas of the fingers].

PMID- 1020909
TI  - [Treatment by autograft of nerve tissue loss].

PMID- 1020910
TI  - [Role of the digitopalmar discharge incision in preventing posttraumatic edema].

PMID- 1020911
TI  - [Large permanent effusions in anterior lipectomy].

PMID- 1020912
TI  - [Value of the biological study of cultured cells from benign pigmented nevi. A
      preliminary study].

PMID- 1020913
TI  - [The clip: treatment of keloids of the ear lobe by sustained, prolonged
      compression].

PMID- 1020914
TI  - [Plastic surgery and esthetics].

PMID- 1020915
TI  - [Must Achilles tendon ruptures still be operated on].

PMID- 1020916
TI  - Prolactin regulation in 14 cases of galactorrhea and hypogonadism with minimal
      modifications of the sella turcica (author's transl).
AB  - In this study we report 13 cases of amenorrhea-galactorrhea and one of a male
      patient complaining of gynecomastia, galactorrhea, sexual impotence and sterility
      with oligoasthenospermy. In these cases, the size of the sella turcica was normal
      but we found a localized depression of the bottom of the sella turcica; these
      modifications were situated at the antero-inferior part of the sella in 12 cases
      and posteriorly in the 2 others. Basal prolactin level was higher than normal
      values in 13 cases (12 female and 1 male patients): individual values varied
      between 45 and 367 ng/ml. Nycthermeral rhythm disappeared in the 9 cases studied.
      Administration of L-Dopa (500 mg orally) significantly suppressed the prolactin
      values in the 11 cases studied. Oral water loading (20 ml/kg) left prolactin
      values unchanged (10 cases). After oral glucose tolerance test (1 g/kg) no
      significant systematic variation occurred. The increase of prolactin values after
      stimulation by 200 microg. TRH IV as a bolus (4 cases) was not significant. We
      have found similar prolactin variations in cases of hyperprolactinemia with
      either normal pituitary fossa (7 cases) or macro-adenoma (6 cases).

PMID- 1020917
TI  - [An electroencephalographic study of olfactory gonadic dysplasia (author's
      transl)].
AB  - The morphological functional and electrophysiologic findings of the report of
      olfactory gonadic dysplasia are reviews. The 11 cases are then presented with the
      analysis and interpretation of the EEG traces (17), as well as studies of
      olfactory activation of the EEF (6 subjects) and of afternoon sleep polygraphy (2
      subjects). There is discussion of the possible sites of dysfunction in the
      mesencephalic-limbic structures which could be the source either directly or
      indirectly of the EEG modifications. Certain EEG abnormalities (interhemispheric
      asymmetry) alow the consideration that the pathogenetic mechanisms of the
      syndrome began during ontogenesis (in 5 of 11 subjects). Thereby suggesting that
      an electrophysiologic examination can be a valuable tool to pick up olfactory
      gonadic dysplasia early and to follow the hormonal treatment in the confirmed
      cases.

PMID- 1020918
TI  - [Influence of reduced pterines and juvenile hormone on the intersexuality of the
      phasmid Carausius morosus (author's transl)].

PMID- 1020919
TI  - [Production rate and mean plasma concentration of cortisol in hyperthyroidism
      (author's transl)].
AB  - The adrenocortical function was studied in 23 patients with hyperthyroidism. The
      half-life of tritiated cortisol was significantly shortened; metabolic clearance
      rate was about twice increased, and production rate of cortisol was significantly
      increased in hyperthyroidism. The mean plasma concentration was unmodified. After
      return to euthyroid state, all the values were normalized in 7 patients.

PMID- 1020920
TI  - [Inadequate corpus luteum function in benign breast-diseases (author's transl)].
AB  - The amount of progesterone and estradiol secreted by human corpus luteum depends
      upon an adequate release of FSH and LH by pituitary gland during follicular phase
      and ovulation. In this paper, plasma determination of progesterone and estradiol
      were carried out in 109 women with benign breast disease during the luteal phase
      of their menstrual cycle. Results obtained were compared with those observed in
      25 normal women studied in the same conditions. In women with benign breast
      disease, the curve of daily progesterone concentrations during luteal phase was
      lower than that of normal women. The progesterone peak at 5th day of luteal phase
      was only 8,1 +/- 3.8 ng/ml instead of 17.2 +/- 3.5 ng/ml in normal women. No
      significative difference was observed concerning plasma estradiol between
      patients and normal women. These results indicate that women with benign breast
      disease have an inadequate corpus luteum function which may be the result of
      disorder of ovulation. Pathophysiological implications resulting from this
      observation are discussed.

PMID- 1020921
TI  - Effects of fenfluramine and cyproheptadine on growth hormone secretion.
AB  - The behaviour of GH, its biological behaviour and response to insulin-induced
      hypoglycemia in obese and underweight patients, of ages varying from 10 to 39
      years, was studied before and after treatment wie circadian course of the hormone
      following adminstration of either drug. Neither did pre-treatment with
      fenfluramine and cyproheptadine, No modification was noted in the circadian
      course of the hormaone following administration of either drug. Neither did pre
      treatment with cyproheptadine modify the hormonal level in the stimulated test.
      It was, however, noted that pre-treatment with fenfluramine appears to influence
      the somatotropinic response to insulin-induced hypoglycemia, yet of  different
      significance in children and adults.

PMID- 1020922
TI  - [Endocrinotropic actions of the benzamide sultopride (author's transl)].
AB  - The influence on the pituitary hypothalamic system of Sultopride are different of
      those of a chemically related compound, Sulpiride. In the mammary gland the
      development of the acini is associated with an increase of the connective tissue.
      The processus of secretion, lactogenesis is quiet not stimulated. The changes on
      the anterior lobe of the pituitary involve the carmino and eosinophilic cells.
      This modification seems to reflect a stimulation of the secretion of LT and an
      inhibition of the release of STH. In the juvenile rat, Sultopride determines an
      inhibition of the somatic growth.

PMID- 1020923
TI  - [Ultrastructural study of stimulation induced by sulpiride on prolactin and
      gonadotrope cells of hypophysis in male and female rats (author's transl)].
AB  - This study concerns the analysis of the ultrastructural modifications in the
      hypophysis induced after repeated administration over a period of one to five
      weeks of Sulpiride in male and female rats. The hyperplasia and hypertrophy of
      the prolactin cells, as well as the dilatation of the intercellular spaces are
      increased with duration of treatment. The prolactin cells present: a highly
      developped R.E.R., very rich in ribosomes, a hypertrophied Golgi area showing an
      active condensation in granules of the secreted material. A massive extrusion of
      mature and immature granules at the level of the plasmic membrane is observed
      throughout the treatment. The Sulpiride, therefore, induces a strong activation
      of the hormonal synthesis and release in the prolactin cells. The gonadotrope
      cells also show a strong stimulation and the same cytologic modifications that
      are found in the castrated animal. The thyreotrope and somatotrope cells do not
      appear affected by Sulpiride treatment. The possibility of a direct action by
      Sulpiride on the hypophysis is discussed.

PMID- 1020924
TI  - Development of a radio-immuno-assay for oxytocin.
AB  - High affinity antibodies against oxytocin were produced by multiple intradermal
      injections. The antibodies do not cross react with lysine vasopressin. Reduction
      of the S-S link changes the immunoreactivity. The high affinity constant of the
      antibodies allows direct RIA of oxytocin in diluted plasma (1:5), with a
      sensitivity of at least 4 muU/ml. Preliminary results for oxytocin determination
      in human umbilical cord plasma range between 15 - 100 muU/ml.

PMID- 1020925
TI  - [Effect of progesterone on the hypertriglyceridemia due to the diet and the
      oestrogens (author's transl)].

PMID- 1020926
TI  - [Influence of sucrose and many fats on carbohydrate metabolism and insulinemia by
      the rat (author's transl)].
AB  - Rats are fed during one month with normal diet or diet enriched with 25% of many
      fats. It is no change of the hyperglycemia curve with the addition of 25% sucrose
      to these diets but 1 degree by male on the normal diet or on the diet enriched
      with corn oil the insulin discharge is higher; it is no change with the diet
      enriched with beef fat or with M.C.T. 2 degrees by the female the insulin
      discharge is higher with all the diets.

PMID- 1020927
TI  - [Diffuse skin mastocytosis of nurslings. 3 clinical cases with bullous
      manifestations].
AB  - Three nurslings are described with diffuse mast cell disease characterized by
      blisters on widespread skin involvement. The skin changes may be associated with
      important generalized flares in relation with degranulating mast cell. The
      mastocytosis infiltrats seems localized to the skin. The skin lesions heal or
      regress slowly as in other mast cell disorders but long-term evolution remains
      very impredictable.

PMID- 1020928
TI  - [Nail lesions in Bournville tuberous sclerosis in isolation or associated with
      Koenen tumors].
AB  - On the basis of three cases, the authors describe the main changes seen in the
      nails in Bourneville tuberose sclerosis, not only in fingers with a Koenen tumour
      but also in association with simple cuticular hyperkeratoses and in fingers with
      no apparent lesion of the matriceal region. They feel that the description of
      these ungual lesions should take its place alongside the major cutaneous signs of
      this disorder.

PMID- 1020929
TI  - [Pharmacokinetics of penicillins in the blood of dogs administered the
      combination preparation, ampiox, internally].
AB  - The pharmacokinetics of penicillins in the blood of dogs treated with ampiox, a
      combination of ampicillin and oxacillin at a ratio of 1 : 1 was studied. The drug
      was administered orally in single or repeated doses of 25, 50 and 100 mg/kg. The
      maximum levels of ampicillin in the blood serum were observed 1 hour after a
      single administration of the drug. The therapeutic concentrations of the
      antibiotic were preserved for 6 hours, its value being depended on the dose used.
      The maximum concentration of oxacillin was detected 1 hour after the drug
      administration in various doses and it was preserved in the blood at the
      therapeutic levels for 3 hours. The dynamics of circulation of ampicillin and
      oxacillin administered separately did not differ from that established for the
      use of ampiox. The regularities of the pharmacokinetics of ampiox on its repeated
      use remained practically unchanged.

PMID- 1020930
TI  - [Erythromycin penetration into the cerebrospinal fluid of patients].
AB  - Permeability of erythromycin through the barrier of blood-cerebrospinal fluid in
      neurosurgical patients after its oral administration in a dose of 300-500 mg and
      intravenous administration in a dose of 200 mg was studied. The erythromycin was
      determined after the antibiotic single administration at intervals of 40 minutes
      to 6 hours. A total of 31 observations were performed. Low penetration of
      erythromycin into the cerebrospinal fluid of the patients was shown. The
      administration route (oral or intravenous) practically had no effect on the
      antibiotic penetration level into the subarachnoidal spaces. The highest liquor
      levels were observed within the period of 3 to 6 hours after the drug
      administration. The maximum index of penetration from the blood into the
      cerebrospinal fluid was about 10 per cent. The erythromycin penetration increased
      in cases with inflammatory changes in the meninges.

PMID- 1020931
TI  - [Toxicity and cumulative properties of carminomycin, rubomycin and adriamycin at
      different times of use].
AB  - LD50 of karminomycin, rubomycin and adriamycin were determined after their single
      administration or 3-, 5-, 10- and 15-fold administration once a day to 540 hybrid
      male mice F1(C57B1 X CBA). Comparison of the cumulative indices for these
      antibiotics showed that after injections they were close. After 5 injections the
      cumulative properties were more pronounced for adriamycin. After 10 or 15
      injections the cumulative properties were less pronounced for karminomycin.

PMID- 1020932
TI  - [Biosynthesis of 14C- and 35S-lincomycin using different sources for the label].
AB  - The sources of radioactive labels were chosen for biosynthesis of labeled
      lincomycin. The levels of the label incorporation into lincomycin were high with
      all the sources used when the lincomycin-producing organism was cultivated on the
      synthetic medium as compared to the complex medium. Incorporation of the label
      into lincomycin was most effective when I14C- or 214C-thyrosine was used as the
      precursors. These precursors were effective in both the complex and the synthetic
      media. In production of significant amounts of the labeled lincomycin I14C- or
      214C-sodium propionate, I14C- or 142C-sodium acetate and 14C-protein hydrolysate
      may be used as the sources of the radioactive carbon. In production of 35S
      lincomycin K235SO4 may be used as the source of the label. The optimal conditions
      for biosynthesis of 14C- and 35S-lincomycin were developed (concentration of some
      components of the medium, time of the label addition and others).

PMID- 1020933
TI  - [Quantitative determination of 7-phenoxyacetamidodesacetoxycephalosporanic acid].
AB  - 7-Phenoxyacetamidodesacetoxycephalosporanic acid, an intermediate product in
      synthesis of cephalexin, was prepared by oxydation of phenoxymethylpenicillin
      into the respective sulphoxide and transformation of the latter. The UV-spectra
      of the reaction products were studied. A quantitative method is proposed for
      determination of 7-phenoxyacetamidodesacetoxycephalosporanic acid in the finished
      products based on estimation os the coefficient of specific extinction of the
      ethanol solutions at a wave length of 268 um in the UV-spectrum region in
      combination with semiquantitative estimation of the admixtures with the method of
      thin-layer chromatography.

PMID- 1020934
TI  - [Study of the carbohydrate metabolic enzyme activity of Act. noursei].
AB  - Activity of aldolase and threosophosphate dehydrogenase, transketolase and
      phosphogluconate dehydrogenase in Act. noursei, strain 153 and its inactive
      mutant 149 was studied comparatively. The enzyme activity of the inactive mutant
      was investigated in the absence of the antibiotic production and under conditions
      of reduced biosynthesis of nystatin in this strain after addition of the
      fermentation broth filtrate of the inactive mutant 369 to the medium. The
      activity of the enzymes of the hexosomonophosphate metabolic pathway in the
      active strain 153 of Act. noursei was 2-4 times higher than that of the inactive
      mutant 149. The activity of the enzymes of the hexosomonophosphate metabolic
      pathways increased and reached the level of the enzyme of the active mutant. The
      high level of the enzyme activity of the hexosomonophosphate glycolysis pathway
      is probably one of the necessary conditions for nystatin production.

PMID- 1020935
TI  - [Comparative antibiotic sensitivity of different species of staphylococci
      isolated from humans].
AB  - A total of 206 strains of various staphylococcal species isolated from various
      sources were studied with respect to their sensitivity to 18 antibiotics. The
      number of strains poly-resistant to the antibiotics was almost the same among
      Staph. aureus and Staph. epidermidis, i. e. 54.8 and 51.3 per cent respectively.
      The coagulase-negative and mannitol-negative variants of Staph. aureus and Staph.
      epidermidis possessing high biological activity (10-14 properties) were resistant
      to more antibiotics as compared to the low active strains.

PMID- 1020936
TI  - [New producer of cephamycin C, Streptomyces filipinensis var. cephamycini var.
      nov].
AB  - An actinomycetes strain 3016 was isolated from a soil sample on a selective
      medium with actinomycin as a result of directed screening of organisms producing
      beta-lactam antibiotics. The culture fluid of the isolate contained an
      antibacterial anibiotic identical to cephamycin C. Description of the strain is
      presented. It is a representative of new variety of streptomyces filipinensis
      var. cephamycini var. nov. The results of the study of the chemical properties of
      antibiotic 3016 and its identification with cephamycin C are also presented.

PMID- 1020937
TI  - [Effect of aeration conditions on the biosynthesis of carminomycin by an
      actinomadura carminata culture].
AB  - The effect of the aeration rate on biosynthesis of carminomycin by Actinomadura
      carminata and biochemical changes in the fermentation broth on the use of 3
      complex media of different composition was studied. The carminomycin-producing
      organism can grow and produce the antibiotic within the ranges of the aeration
      changes from 0.98 to 18.56 mgO2/1-min. A decrease in the maximum rate of oxygen
      dissolution up to 0.98 mgO2/1-min resulted in some decrease in the activity
      level. Intensive aeration, i.e. 18.56 mgO2/1-min induced suppression of the
      antibiotic production by 25 per cent.

PMID- 1020938
TI  - [Pleiotropic effect of the mutation of streptomycin resistance in Micromonospora
      purpurea var. violacea].
AB  - Variation of different features of populations of streptomycin-sensitive and
      streptomycin-resistant forms of M. purpurea var. violacea, an organism producing
      gentamicin was studied. The population of the initial streptomycin-sensitive
      culture was characterized by high homogeneity with respect to the cultural,
      morphological and some physiological properties. The variation of the features,
      such as the colony size, pigment formation, auxotrophic mutations, antibiotic
      production significantly increased in populations grown on media with
      streptomycin. Mutants differing from the initial strain by a complex of cultural,
      morphological and physiological features and in particular the antibiotic
      production were isolated from populations of the streptomycin-resistant variants.

PMID- 1020939
TI  - [Antagonistic interrelationships between the staphylococci and Sarcina isolated
      from the upper respiratory tracts of virtually healthy persons].
AB  - The antagonistic activity of staphylococci isolated from the mucosa of the
      anterior parts of the nose of practically healthy persons was studied with
      respect to 102 strains of Sarcinia. Staphylococcus aureus had the most pronounced
      inhibitory effect on Sarcinia. No difference in the antagonistic activity of the
      staphylococci isolated from the carriers of the permanent and transitory types
      was found. However, Staphylococcus aureus isolated from the permanent carriers
      had a broader activity spectrum.

PMID- 1020940
TI  - [Sensitivity of some Lactobacillus species of the subgenus Betabacterium to the
      action of bacteriocins from different species of Lactobacillus].
AB  - Sensitivity of 84 cultures of L. fermenti, 43 cultures of L. brevis, 13 cultures
      of L. buchneri and 2 cultures of L. cellobiosus to the effect of 39 types of
      bacteriocins produced by various species of lactobacilli was studied with the
      method of delayed antagonism. All the cultures of L. brevis, L. buchneri and L.
      cellobiosus and 65.5 per cent of the cultures of L. fermenti were sensitive to
      one or more such bacteriocins. The cultures of L. Fermenti, L. brevis, L.
      buchneri and L. cellobiosus were sensitive respectively to 37, 19, 16 and 9 types
      of the bacteriocins out of 39 types tested.

PMID- 1020941
TI  - [Mechanism of the heterogeneity of a staphylococcal population with respect to
      methicillin resistance].
AB  - The study of the staphylococcal population heterogeneity with respect to
      methicillin resistance by 2 methods revealed different numbers of the resistant
      cells in the population. Thus, when the microbial suspension was plated on an
      agarized medium with methicillin (50 gamma/ml), only 0.0007--0.0005 per cent of
      the resistant cells were found. When the colonies were replicated from a medium
      without methicillin to a medium containing methicillin (50 gamma/ml), 84.3--97.3
      per cent of the resistant microbial cells were found in the population of the
      same strains. The main mechanism in the heterogeneity of the staphylococcal
      population with respect to methicillin resistance was impairement of the
      phenotype manifestation of the antibiotic resistance under definite conditions.

PMID- 1020942
TI  - [Pharmacokinetics of lincomycin in experimental animals].
AB  - When administered parentally, lincomycin satisfactorily penetrated into the
      organs and tissues of experimental animals. Pronounced tropism of the antibiotic
      in the bone tissue was observed which provided its recommendation for the
      treatment of osteomyelitis. The antibiotic was excreted with urine and bile.

PMID- 1020943
TI  - [Experimental data on the penetration of gentamicin into the media of the eye].
AB  - Penetration of Soviet gentamicin into the humor of the anterior chamber and
      vitreous body of the eye with aseptic inflammation was studied after the
      antibiotic administration by various routed, i.e. instillations of 8 per cent
      antibiotic solution and 8 per cent antibiotic solution methylcellulose into the
      conjunctival sac, injections of 20 mg of gentamicin subconjunctivally and
      retrobulbarly, injections of gentamicin intramuscularly in doses of 0.6 mg/kg.
      The studies showed that gentamicin penetrated into the humor of the anterior
      chamber and vitreous body of the eye after all the administration routes
      mentioned above in concentrations sufficient for the antibiotic antimicrobial
      effect and persisted in the eye media for prolong periods of time (24--48 hours).
      The highest concentrations of the antibiotic in the tumor of the anterior chamber
      were achieved after its administration subconjunctivally or after instillation of
      its 8 per cent on methylcellulose, while in the vitreous body its highest
      concentrations were achieved after injections subconjunctively, retrobulbarly or
      intramuscularly. Instillations of gentamicin solution on methylcellulose provided
      higher and more persistant concentrations of the antibiotic in the humor as
      compared to instillations of its aqueous solutions. Retrobulbar injections of
      gentamicin had no advantages as compared to subconjunctival administration with
      respect to providing higher concentrations of the antibiotic in the eye media.

PMID- 1020944
TI  - [State of phagocytic immunity in white mice treated with doxycycline and pentoxyl
      for experimental staphylococcal sepsis].
AB  - When albino mice with experimental staphylococcal sepsis were treated by
      doxycycline for 10 days, it was noted that the antibiotic had an inhibitory
      effect on the absorbing capacity of the peritoneal leucocytes with respect to
      Staph aureus. The decreased digesting capacity of the leucocytes was observed
      only during the first 5 days from the moment of infection and treatment. The
      combined use of doxycycline and pentoxyl stimulated the activity and intensity of
      phagocytosis. The activity values of completed phagocytosis did not change, while
      the coefficient of the phagocytosis completeness increased as compared to the
      same values in the animal group treated with doxycycline alone.

PMID- 1020945
TI  - [Comparative study of the cardiotoxicity of the anthracycline antibiotics,
      carminomycin and adriamycin, in white mice].
AB  - The cardiotoxic effect of karminomycin and adriamycin administered intravenously
      for 5 times in equitoxic doses constituting equal portions of LD50 of the
      respective antibiotic on its single intravenous administration was studied on
      albino mice. Histological examination of the heart showed that almost identical
      damages of the myocardium occured after administration of karminomycin and
      adriamycin in doses of 0.45 of LD50 (1.5 mg/kg) and 0.3 of LD50 (6.3 mg/kg)
      respectively. The character of the damages due to the antibiotics was close, the
      most significant changes were observed when the animals were sacrificed 1 month
      after the last administration of the drug. The histological method is of value in
      estimation of the cardiotoxic effect of the drugs, using mice as the model
      suitable for the investigation. Adriamycin had more pronounced cumulative
      properties as compared to karminomycin: suppression of the weight gain in the
      mice and their death rate were higher with the use of adriamycin.

PMID- 1020946
TI  - [Indices of bacterial contamination and natural resistance in wistar line
      laboratory rats].
AB  - Conventional laboratory rats of Wistar line are contaminated with bacterial
      flora. The predominating bacteria in the intestine were the rod-like forms, while
      in the mouth cavity and vagina predominated the coccal forms. The contamination
      level of the cavities and penetration of the contaminants into the internal
      organs depended on the state of the host natural resistance.

PMID- 1020947
TI  - [Insecticide residue levele in tobacco from 1969-1976].

PMID- 1020948
TI  - [Cytochemical and ultrastructural study of oocyte development of the crab
      Eriocheir sinensis. II. Oogenesis after removal of the eyestalk].
AB  - The effect produced by an eyestalk removal have been studied on Eriocheir females
      at different physiological stages. In juvenile and prepuberal crabs, the
      operation induces an important rise of the oocyte diameter. Only a few variations
      are observed in puberal females oocytes. Cytological changes are found at first
      at the nucleolar level. The granular area increases and the nucleolar vacuoles
      volume decreases. Then the granules (precursor material to endogenous yolk)
      disappear in the reticulum cisternae. At this time, the endogenous yolk seems
      essentially elaborated within yolk lobules. The envelope of these lobules is
      enhanced by ribosomes. In juvenile females (oocytes initially in
      previtellogenesis) exogenous yolk does not appear. Nevertheless in prepuberal
      females, following eyestalks deprivation, the oocytes, initially at the
      endogenous vitellogenesis stage, quickly reach the vitellogenesis second stage.
      In such oocytes, the microvilli development and pinocytose vesicles number are
      greater than normally. Cytochemical tests reactions do not demonstrate
      differences in the yolk material (endogenous and exogenous) nature from
      experimented oocytes and controls. In juvenile and prepuberal oocytes, the
      multivesicular bodies and lysosomes proliferation, the increase in glycogen and
      lipids amount express a metabolic disturbance resulting from an acceleration of
      growth processes. However in eyestalk-less prepuberal females no difference with
      the control oocytes was noticed.

PMID- 1020949
TI  - [Ultrastructure of the proliferation of astrocytes and microglia].
AB  - Glial cell proliferation was studied during axonal reaction of hypoglossal nerve,
      and around stab wound in the brain cortex of the rat. The cytoplasm and
      chromosomes of astroglial mitoses were pale. Lipid droplets, few sparse dense
      bodies with heterogenous structure were present in the cytoplasm. The mitotic
      astrocytes had irregular outlines. The ultrastructure of "light microglial" cells
      was described; it was found that these cells divided and gave rise to microglial
      cells. The cytoplasm and the chromosomes of microglial mitoses were dense; the
      cytoplasm contained always groups of dense bodies and lipfuscine granules. The
      outlines of mitotic microglial cells were more regular.

PMID- 1020950
TI  - [Contribution of somite cells to the development of posterior limb buds in mice].
AB  - 1. The structural changes accompanying the early genesis of the mouse hindlimb
      bud have been studied in serial Epon thick sections at five successive somitic
      stages collected during the 10th developmental day. 2. As soon as the 14-somite
      stage, increased proliferative activities occurring in a limited area of the
      embryonic somatopleure close to the caudal end of the coelomic cavity point out
      the onset of limb morphogenesis. From its very beginning on, up to its ceasing at
      the 27-somite stage, the somatopleural proliferation is more active in the caudal
      part of the prospective limb territory and in the whole area, it appears stronger
      ventrally than dorsally. 3. Discrete structural changes occur during this period
      in the mesoderm interposed between the hindlimb bud territory and the overlying
      unsegmented sheet of somitic mesoderm, in relation with the genesis of the
      mesonephritic constituents and of the posterior cardinal vein. A detailed
      analysis of this area in serial sections reveals that the unsegmented somitic
      mesoderm does not provide any cell to the limb bud mesoderm. 4. As soon as the
      somitic mesoderm becomes organized into segmented somites, obvious histological
      changes located on the lateral aspect of the ventro-lateral somitic edge reveal
      that numerous undifferentiated somitic cells invade the proximal area of the limb
      bud mesoderm. Starting at the 27-somite stage in the first two metameres adjacent
      to the precordonal portion of the limb bud, this processus extends to the five
      somites of the limb territory at the 33-somite stage. In each metamere, the area
      of cell migration takes place near the caudal border of the somite and, from one
      somite to the other, the number of migrating cells increases in a cephalo-caudal
      direction. No sign of a similar cell migration was observed in the somites
      located cranially or caudally to the hindlimb bud. 5. The results are discussed
      in relation with the various experimental and descriptive evidences obtained in
      non-mammalian Vertebrates about the contribution of the somites to limb
      morphogenesis and about the factors involved in the onset of cell proliferation
      in the prospective limb mesoderm.

PMID- 1020951
TI  - [Ultrastructural aspects of the migration of somite cells to the posterior limb
      buds of mice].
AB  - Migrating cells originating selectively in the ventral lateral edge of the
      somites adjacent to the mouse hindlimb bud have been studied in transverse
      sections by transmission and scanning electron microscopy. Collected during the
      10th and 11th gestational days, the embryos have been classified according to the
      number of metameres. As soon as the 28 somite stage, discrete cytological
      modifications occur in a limited caudal area of the ventro-lateral somitic edge.
      Loosing the typical epithelial arrangement characteristic of the dermatome cells,
      these ventral cells show large areas  of close contact between their plasma
      membrane and a superficial microfilamentous material accumulates in the contact
      areas. At the 33 somite stage, the same groups of cells elongate and form long
      cellular trails invading the proximal area of the limb bud mesoderm. The
      migrating cells become polarized along the migrating axis and they retain large
      and smooth intercellular contacts with each other. Very selective ultrastructural
      features of the migrating somitic cells can be interpreted in relation to their
      cinetic activity or to their early myogenic differentiation. In addition to their
      mutual superficial relationships, the migrating cells are characterized by the
      presence of numerous oriented microtubules, of a high number of active
      mitochondria, of an abundant granular endoplasmic reticulum and of an
      hypertrophied Golgi apparatus regularly located near the nucleus in the
      "trailing" edge of the cells. Several dense granules with a diameter of 8 nm are
      present in the mitochondrial matrix. The extensive Golgi apparatus is associated
      to numerous thick walled vesicles, which increase from 60 to 150 nm in diameter
      as they become closer and closer to the plasma membrane. These vesicles are
      absent in the mesodermal cells of somatopleural origin; their presence in the
      migrating somitic cells is probably related to an early myogenic differentiation.
      The observation made near the distal end of the somitic cellular trails suggests
      that the more distal somitic cells rapidly loose their ultrastructural
      particularities as soon as they are dispersed in the limb bud mesoderm; this
      aspect of the processus, however, requires the study of later developmental
      stages. Other observations made in the same material bring some precisions to the
      ecto-mesodermal relationships which are established in the apical area of the
      limb bud. Scanning electron microscopic observations of thick sections reveal
      that the outer mesodermal cells of this area send numerous filopodia which make
      contact with the basement membrane underlying the apical ectodermal ridge.

PMID- 1020952
TI  - [The effect of boric acid on the development of chick embryos treated at an early
      stage: preliminary results].
AB  - 10 mul of a 2% boric acid solution are injected in chick embryos at 28 hours of
      incubation. The nervous system is always affected in its anterior and middle
      region, with exencephaly and reduction in size of the neural tube. Microphtalmy
      is frequent. The posterior limbs can be likewise altered, leading sometimes to
      symelia. The histological study shows furthermore that the notochord is locally
      hypertrophic or missing, at the same level where the nervous system is altered.

PMID- 1020953
TI  - Histoenzymology of the pineal gland: an optical and electron microscope study.
AB  - The activity of some dehydrogenases is investigated in the rat's pineal gland of
      normal or sympathectomized animals with optical and electron microscopy.
      Comparison is made between the concordances and, particularly, the differences
      observed with the two methods.

PMID- 1020954
TI  - [Anuerysms of the ascending aorta associated with aortic insufficiency].

PMID- 1020955
TI  - [A case of multiple penetrating wounds of the ventricular myocardium treated with
      success].

PMID- 1020956
TI  - [Heteroplastic dysembryomas of the mediastinum (apropos of 15 operated cases)].

PMID- 1020957
TI  - ["Seminoma-like" thymoma (clinical and anatomo-pathological considerations)].

PMID- 1020958
TI  - [Observations on 4 cases of rupture of the right atrium caused by closed chest
      injury].

PMID- 1020959
TI  - [A case of unusual benign neoplasm of the esophagus: cavernous hemangioma].

PMID- 1020960
TI  - [Cystic adventitial degeneration of the popliteal artery].

PMID- 1020961
TI  - [Vaccines and anti-rubella immunity (author's transl)].
AB  - The teratogenic effect of maternal rubella virus infection upon the offspring is
      well established. The present article deals with the problem of susceptibility to
      rubella infection among women in prepubertal and postpubertal age. The
      sieropositivity values in female populations from different italian areas are
      reported. The different types of vaccines for rubella and the preparation
      techniques are reviewed, and the immunity either induced by natural virus
      infection or acquired through vaccination is discussed. The conclusion is drawn
      that it is useful to offer rubella vaccine to girls and that, as far as it is
      known at present, the vaccine RA 27/3 is the most reliable.

PMID- 1020962
TI  - [On the presence of the antibodies against diphtheria and tetanus in a sample of
      population].
AB  - Tth  acquistion of serological techniques, as the HA-induced reaction, which can
      be employed on a large scale, its practical realization, the repeating of its
      results, has made easy the epidemiological serological research and the knowledge
      of the state of immunity of the population against diphtheria and tetanus. The
      Authors, supported by validity of the results achieved, at least in
      epidmiological field, wanted to estimate the presence and the title of the
      antidiphtheria and anti-tetanus antibodies in a sample of population living in
      our area, to know the factors of risk at different age. The results obtained have
      demonstrate as follows: in the group of the subjects ageing from 11 to 20, the
      48,6% have been protective antibodies against the diphtheria and the 29,8%
      against the tetanus. Among the subjects, who have been surely vaccinated for 10
      years at least with on or more doses of vaccine, the Authors have found a largest
      number of immune subjects; in the group of the subjects ageing from 21 to 30 the
      percentage of seropositive subjects is analogus to that one of the former group.
      In the male subjects, the Authors have found a higher percentage of immunity than
      in the female subjects, because the largest number of the former group had done
      their military service; the Authors have, also, observed that those subjects who
      are more than 31 years old, persent a decline in numbers and in percentage of
      those who have antibodies against diphtheria and tetanus. The Authors, on the
      basis of the achieved results, express their opinion about the epidemiological
      and of the immunity situation, and point out the deficiencies, which, in their
      opinion, still constant trickle of cases.

PMID- 1020963
TI  - [Syndrome of the "Lamblia intestinalis" (author's transl)].
AB  - The Authors related the physiopathologic remarks executed on subjects that are
      suffering from Lambia intestinalis. They have been chisen in a group of 226
      individuals who had executed the coprologic test because of symptoms of
      gastroenteric apparatus. With the escort of this observation, the Authors have
      findings, as constant report, a typical enteritis, that reveals itself in
      periodical diarrhoea, alternated with constipation and often accompanied, in the
      children, with gastralgia, in the grown ups with duodenitis. The constancy of
      these reports and the therapeutical succes, whic the have been achieved in the
      most of the cases with antilambliasi, induce them to have reasonable motives to
      attribute to the Lamblia a definite pathogenus entity and to regard it an
      etiologic element of the above-mentioned unhelty courses.

PMID- 1020964
TI  - [Antibody response in humans to A/New Jersey/76 influenza vaccine (author's
      transl)].
AB  - 74 adults 25 to 50 years old have been immunized with a sigle dose of three
      different influenza vaccines, namely: 1. Bivalent A and B (A/Victoria/75 600 IU;
      B/Hong Kong/73 300 IU); 2. Monovalent A/New Jersey/76 400 IU, and 3. Trivalent
      (A/Victoria/75 300 IU; B/Hong Kong/73 300 IU; A/New Jersey/76 300 IU). Reactions
      were insignificant or trivial. One month later antibody content was measured in
      the blood and satisfactory reponses were observed in bivalent and monovalent
      vaccines treated groups. Less satisfactory reponse was observed in the trivalent
      vaccine group, probably according to the lesser antigenic content in A/Victoria
      and A/New Jersey strains.

PMID- 1020965
TI  - [Inquiring of the microorganisms of the tribe Mimeae in subjects with acute
      respiratory affections (author's transl)].
AB  - The incidence of the germs appartening to the tribe of Mimeae yolited during
      acute respiratory affections was studied. The isolement of M. polymorpha and of
      H. vaginicola results positive in the 15% of the subjects examined and
      particularly during acute laringo-tracheobronchitis and hyperpyretical
      bronchopneumonitis. The pathogen function expliqued by Mimeae during the
      affections of respiratory system is important over all in regard of annexed
      therapeutical problems.

PMID- 1020966
TI  - [Observations on the sensibility of many chemical antibodies on the blocks of the
      Mimeae isolated during the acute respiratory affections (author's transl)].
AB  - The AA. studied the sensibility of 7 stocks of Mimeae isolated from subjects with
      acute respiratory affections against numerous chemical antibodies. The observed
      that the examined stocks were sensibility resistent to usual antibiotic employed
      but with a great variability of antwort among the single stocks.

PMID- 1020967
TI  - [Observations of reactions after smallpox vaccination (author's transl)].
AB  - The Author has practised the vaccination against smallpox in two groups of
      children; one with dried-vaccine, the other with calf-vaccine. He describes the
      reactions after smallpox vaccination.

PMID- 1020968
TI  - [Biology of the "Salmonella wien" (author's transl)].
AB  - The Authors after a theoric introduction in regard to the taxonomic position, the
      history and the epidemiology of the Salmonella wien, explain the biologic
      characteristic of the bacterium according to results of their experiments.

PMID- 1020969
TI  - [A simplified micromethod for the measurement of leukocyte chemotaxis (author's
      transl)].
AB  - A new in vitro micromethod for the assessment of chemotaxis, based on the
      measurement of glass-adhering phagocyte migration through a cellulose membrane
      filter in a standard tissue culture chamber, is described. This technically
      simple method, which requires only small volumes of whole blood and produces
      reliable results, may be of promising clinical usefulness for the study of the
      several disease states related to abnormalities of chemotaxis.

PMID- 1020970
TI  - [Experimental studies on the antibacterial activity of the association
      cephaloridine-dicloxacilline (author's transl)].
AB  - A study on the efficiency of the association cephaloridine-dicloxacilline in the
      ratio 2:1 has been carried out. Both in vitro and in vivo the antibacterial
      activity shown by the association is higher than that merely additive of the
      single components and is due to positive interaction.

PMID- 1020971
TI  - [Erythromycin: serum and urine levels following rectal administration (author's
      transl)].
AB  - The serum and urine levels obtained form administration of Erythromycin are
      generally good and the antibiotic is absorbed in a similar way; this happens also
      for the other ways of administration. We have noticed a variability in the
      absorption of antibiotic as the different components present in the suppositories
      administered.

PMID- 1020972
TI  - [Immunological diagnosis of hilarmediastinal lymphadenopathies (author's
      transl)].
AB  - In the last few years, we have adopted the following immunological techniques for
      the study of hilarmediastinal lymphadenopathies: the E and EAC rosette tests
      (composition of the lymphocyte population) for an evaluation of the general
      immunological picture, the delayed-type cutaneous tests to reveal the specific
      picture of cell-mediated immune responses, and the leucocyte migration inhibition
      test against related and unrelated antigens. This cellular technique was
      integrated with the determination of precipitating and agglutinating antibodies
      against the same antigens. Data are reported regarding tubercular and sarcoid
      lymphadenopathies, Hodgkin's disease, and secondary neoplastic lymphadenopathy
      with prevalent intratoracic localization. The techniques used demonstrated that
      tubercular lymphadenopathy is associated with a well defined immunological
      profile which is both humoral and cellular. Sarcoid lymphadenopathy (thoracic
      sarcoidosis) showed a specific, well characterized immunological picture as
      regards cell-mediated immune responses. In Hodgkin's disease (hilarmediastinal
      lymphadenopathy) the immunological technique showed up a general, depressed
      immunological picture, particularly as regards the cell-mediated immunitary
      response, presumably partly due to the treatment given (physical and
      pharmacological therapy). Secondary neoplastic lymphadenopathy showed a similar
      pattern, as far as the immunological parameters used until now are concerned. On
      the basis of experience gained to date, we believe that the immunological
      techniques can make a contribution to diagnostic and clinical studies of
      tubercular and sarcoid lymphadenopathies.

PMID- 1020973
TI  - [The anti-tetanus serumprophylaxis (author's transl)].
AB  - The antitoxin titre against tetanus toxin has been evaluated in wounded subjects
      before and 24 after anti-tetanus serumprophylaxis by passive haemagglutination.
      Treatment with digested heterologous antiserum (3000-6000 I.U.) or with human
      hyperimmune immunoglobulins does not modify preexisting antitoxin titre. Serum
      negative subjects remain as such.

PMID- 1020974
TI  - Callosal transfer of impulses originating from superficial and deep nerves of the
      cat forelimb.
AB  - 1. Experiments were performed in 18 chloralose-anaesthetized, curarized cats in
      order to study the callosal transfer of somatic information originated in
      exteroceptive and proprioceptive receptors. Several cutaneous and deep nerves of
      the forelimb were prepared and stimulated with graded intensities, so as to
      activate selectively afferent fibres pertaining to the different groups of
      Lloyd's classification. Simultaneous records were taken (and averaged on-line by
      means of a multichannel analyzer) from the distal end of a cut dorsal rootlet (C7
      C8), from the cerebral cortex (SI, SII or area 3a, according to the experiment)
      and from the somesthetic callosal region (SCR). 2. The low-threshold afferent
      fibres (Group II) of cutaneous origin were found to have a wide projection to the
      SCR, with the maximal density in its middle portion. Some of the fastest
      corticocallosal impulses are relayed monosynaptically at cortical level. Plots of
      the amplitude of cortical and callosal responses as a function of stimulus
      strength showed that both central responses have the same threshold and exhibit a
      parallel, sharply-rising amplitude increase, thus suggesting that the cortico
      callosal re-transmission system for afferent impulses of cutaneous origin is very
      powerful in nature. Impulses elicited in afferent fibres of higher threshold
      (Group III) do not enhance the cortical and callosal positive waves provoked by
      Group II afferent volleys. 3. Afferent fibres of deep origin were also found to
      send a wide projection to the SCR, although less substantial than that of
      cutaneous fibres. Stimulation of the deep radial nerve elicited mass responses in
      the whole SCR, provided the strength of stimuli was high enough to engage the
      Group II fibres. Only in the central portion of the SCR were small potentials
      recorded in response to pure Group I volleys of DRN. Experiments performed with
      selective stimulation of pure muscular branches of forelimb deep nerves as well
      as of articular and mixed (muscular and articular) branches gave evidence making
      it possible to ascertain the origin of deep afferent fibres projecting to the
      SCR. Stimulation of the forelimb muscular branches with strength provoking full
      activation of Group I afferent and additional engagement of those of Group II,
      did not provoke mass responses in the whole extent of the SCR. In order to obtain
      callosal potentials upon stimulation of pure muscular nerves, it was necessary to
      increase the stimulus strength at or above the threshold for Group III fibres. On
      the contrary, the same callosal foci unresponsive to Group I and II muscular
      afferent volleys exhibited clear-cut responses to stimulation of the lowest
      threshold Group I and/or Group II afferents of articular and mixed nerves. From
      the results it might be inferred that only proprioceptive information originating
      from articular receptors and from extrafusal muscular afferents has access to the
      callosal interhemispheric transfer.

PMID- 1020975
TI  - Somatotopic localization of the eye muscle afferents in the semilunar ganglion.
AB  - In the medial dorsolateral portion of the semilunar ganglion of curarized and
      anaesthetized lambs a cellular pool has been identified which contains the
      perikarya of the first-order neurons of the eye muscle proprioception. Responses
      to moderate manual stretch of individual eye muscles were recorded by means of
      tungsten microelectrodes, from single units of the ganglion. They were of the
      type induced by muscle spindle excitation. Such responses showed a somatotopic
      localization. The superior rectus and the superior oblique muscles were
      represented in the most dorsal layers of the ganglion, while the inferior rectus
      and the inferior oblique muscles projected on the most ventral portion of the
      pool. The medial and the lateral recti were represented in the medial and lateral
      parts and occasionally wedged themselves between the cells innervating the
      superior and the inferior muscles. Thus a somatotopic arrangement of the eye
      muscle proprioception has been demonstrated for the first time in the semilunar
      ganglion.

PMID- 1020976
TI  - Crossed inhibition as revealed by cross-correlogram between bilateral homonymous
      motor unit spikes in man.
AB  - Neuromuscular unit (NMU) spikes activated during the tonic vibration reflex (TVR)
      in man were studied by means of the cross-correlogram test. Those NMUs which
      preferredly fired at some definite interval with good correlation with vibration
      were called "locked" spikes. The amount above zero correlation level seen in the
      cross-correlogram was expressed as ipsilateral "excitatory frequency", Ef. TVR
      contraction of the ipsilateral quadriceps femoris muscle was stimulated by
      voluntary contraction of the contralateral quadriceps femoris. I. Cross
      correlogram test of the contralateral voluntary NMU spikes with ipsilateral
      vibration revealed "contralateral inhibitory modulation". Such inhibitory
      modulation was observed in 24% of the contralateral NMUs during voluntary
      tracking contraction with visual feed-back and in 22% of NMUs during blind
      simulated contraction without visual feed-back. The "subtracted" amount, i.e.,
      contralateral inhibitory modulation, was also expressed as the contralateral
      "inhibitory frequency", If, which was calculated from the indentations of the
      cross-correlogram. 2. When varied vibratory frequency was applied to the muscle
      both Ef and If attained their maximum value around an "optimal frequency" of
      vibration, i.e., 80-95 HZ. 3. The ratio Ef/If was proposed as the reciprocal co
      activation ratio which was fairly independent of the change of vibratory
      frequency. An average value of Ef/If ratio was calculated at 2.2 +/- 0.9 from 19
      experiments.

PMID- 1020977
TI  - Tonic inhibition of dorsal pontine neurons during the postural atonia produced by
      an anticholinesterase in the decerebrate cat.
AB  - 1. Experiments performed in precollicular decerebrate cats indicate that neurons
      located in the caudal part of the locus coeruleus and locus subcoeruleus as well
      as in the surrounding reticular formation were greatly depressed during the
      cataplectic episodes induced by i.v. injection of 0.1 mg/kg of eserine sulphate.
      2. These units actually showed a slow regular firing rate when the rigidity was
      present. Moreover their firing rate greatly decreased during the episodes of
      postural atonia produced by the anticholinesterase. In some instances a complete
      abolition of firing occurred during these episodes. The depression of unit
      discharge anticipated the onset of postural atonia and lasted throughout the
      episodes. 3. Some of the neurons described above responded with steady changes in
      their discharge rate to natural stimulation of macular labyrinthine receptors
      during postural rigidity. However, the response of these neurons to lateral tilts
      was suppressed during the episodes of postural atonia induced by the
      anticholinesterase, This and other arguments suggested that these units were
      tonically inhibited during the induced cataplectic episodes. 4. The time course
      of the rate deceleration shown by these neurons during transition from postural
      rigidity to muscular atonia represents a mirror image of the rate acceleration
      which affects most of the pontine reticular neurons located in the
      gigantocellular tegmental field (FTG) during the induced cataplectic episodes.
      These reciprocal rate relations suggest that a functional interaction exists
      between the two cell groups. In particular it is postulated that the pontine FTG
      neurons are self-excitatory and excitatory to the locus coeruleus neurons, while
      the last neurons may be self-inhibitory and inhibitory to FTG neurons. These
      findings can be related to previous observations showing that neurons located in
      the region of locus coeruleus undergo a rate deceleration during desynchronized
      sleep which mimics the time course of firing to the pontine reticular neurons. 5.
      In conclusion it appears that the decerebrate rigidity is present in so far as
      the cholinergic reticular neurons, which trigger the bulbospinal inhibitory
      system, are tonically inhibited by neurons located in the monoaminergic
      structures of the dorsolateral pontine tegmentum. On the other hand the
      suppression of the decerebrate rigidity ,which occurs during the cholinergically
      induced cataplectic episodes results from activation of the cholinergic reticular
      neurons, which escape tonic inhibition from monoaminergic structures.

PMID- 1020978
TI  - Relations of single semicircular canals to the pontine reticular formation.
AB  - The effects of afferent vestibular impulses on single pontine reticular formation
      units and on a small filament of the IIIrd cranial nerve were recorded with
      tungsten microelectrodes in 40 curarized guinea pigs. Single-shock and repetitive
      electrical stimulations were applied by means of stimulating electrodes inserted
      bilaterally into the perilymphatic space of single ampullae of the anterior and
      lateral semicircular canals. The reticular unitary response consisted mainly in
      excitation of the resting discharge rate: most units showed vestibular
      convergence being affected by separate stimulation of the single four ampullae.
      the reticular evoked field and unitary potentials accounted for latency values
      ranging from 0.3 to 2.5 msec. As for the early latencies they can be interpreted
      as responses mediated by direct vestibulo-reticular fibres. A delimited
      vestibular projection field in the parameidan pontine reticular formation was not
      identified.

PMID- 1020979
TI  - [Trigeminal course of sensory fibers derived from extrinsic eye muscles in the
      cat].

PMID- 1020980
TI  - Degenerative and regenerative processes in the olfactory system of homing
      pigeons.
AB  - Experimental resection of the olfactory nerve in the homing pigeon induces a
      total degeneration of the nerve and olfactory epithelium. The orthograde
      degenerative process starts before the retrograde one. Ten days after resection,
      new neurons begin to differentiate from the basal cells. The axon forms earlier
      than the distal dendritic process, and the speed of growth increases slowly. The
      regenerated axons only reach the bulb in the 5th month. Two months after
      resection the olfactory epithelium is similar to that of the intact control side.
      The ultrastructural features of the mucosa and olfactory axons are similar to
      those of normal ones.

PMID- 1020981
TI  - Vestibular nuclei of hemilabyrinthectomized guinea pigs during decompensation.
AB  - 1. The effects of the post-brachial section of the spinal cord on the field
      potentials recorded from the vestibular nuclei during stimulation of the right
      vestibular receptors have been studied in left hemilabyrinthectomized and then
      compensated guinea pigs. 2. Facilitation of the field potentials in the right
      vestibular nuclear complex and inhibition in the left nuclei have been observed.
      3. These results confirm that the spinal cord is involved in the compensation of
      the release syndrome brought about by the lesion of one labyrinth. 4. The
      possible mechanisms underlying such a compensation are discussed.

PMID- 1020982
TI  - Aetiology of sarcoidosis.

PMID- 1020983
TI  - Epidemiology of sarcoidosis.

PMID- 1020984
TI  - [Sarcoidosis throughout the world. Analysis of 3,676 cases].

PMID- 1020985
TI  - [Sarcoidosis in Italy. Analysis of 716 cases].

PMID- 1020986
TI  - [Diagnosis of disseminated pulmonary processes of miliariform and noduliform
      appearance].

PMID- 1020987
TI  - [Suspected sarcoidosis in patients with breast cancer].

PMID- 1020988
TI  - [Statistical analysis of febrile convulsions in childhood. Eletroclinical study
      of 505 cases].

PMID- 1020989
TI  - [Metabolism of tryptophan in the mentally retarded].

PMID- 1020990
TI  - [Morphological bases of the evolution of the EEG in humans. II. Study in human
      fetuses 5 months of intrauterine life up to 6 months postpartum].

PMID- 1020991
TI  - [Usefulness of the EEG examination in a Social Security outpatient clinic
      (analysis of 1,000 cases)].

PMID- 1020992
TI  - [Examination of pork quality using passive electric methods].
AB  - Passive electrical values of 76 probes of pig M. long. dors. with different
      quality are derterminated. It appears, that a factor (P = value), exactly
      ascertained from electrical parameters, is fit to characterize the quality of
      pork. The P-value is theoretical established and has relations to the stability
      of the membrane structures.

PMID- 1020993
TI  - [Wohlfahrtia magnifica (Schiner, 1862) Diptera: Sacrophagidae) causing a vaginal
      myiasis in domesticated two-humped camels in the Mongolian People's republic].
AB  - Wohlfahrtia magnifica (Schiner, 1862) [Diptera: Sarcophagidae] was established as
      the causal agent of a vaginal myiasis in female camels in the Mongolian
      Democratic Republic. Changes of the genitals occur nearly the beginning of June,
      4-6 weeks after foaling, a spontaneous recovery is seen at the beginning of
      October. Clinical signs of the vaginal myiasis and morphology of the three stages
      of larvae are described in detail.

PMID- 1020994
TI  - [Studies on anesthetized and nonanesthetized slaughter swine. 1. Blood pressure].
AB  - The blood pressure of pigs for slaughter were measured. Onset of electric
      anaesthesia was followed by blood pressure rise of about 25 per cent. Peak values
      of 100 per cent in excess of the original pressure were recorded in some cases.
      Termination of the electric stimulus, generally, was followed by sudden blood
      pressure drop. The original pressure usually was reached ten seconds from the
      debleeding puncture. With continued debleeding, it stayed at 75 mm Hg after 50
      seconds on average. Extraordinary high rise in blood pressure in response to
      electric stimulation usually was followed by rapid pressure drop, whereas in
      cases with moderate rise at the time of anaesthesia the subsequent decline was at
      slower rates.

PMID- 1020995
TI  - [Quantitative morphological studies on various organs of the MINI-LEWE miniature
      swine].
AB  - Quantitative morphological studies were conducted into 27 MINI-LEWE miniature
      pigs, with the view to exploring the correlations between a number of organs
      (liver, kidneys, heart, spleen, pancreas, adrenal gland, and thyroid gland) and
      parameters (live weight, age, weight at slaughter, length from snout to tail
      root, and internal length of slaughter body). The results are presented in 12
      ilustrations and five tables.

PMID- 1020996
TI  - [Murine model for experimental studies on attenuated mutants of a Pasteurella
      multocida strain with pathogenicity for the calf. 2. Primary immunization against
      lethal infection, using fully attenuated streptomycin-dependent (Sm-d) mutant and
      booster immunization with partially attenuated streptomycin-dependent (Sm-id)
      revertants].
AB  - An experimental study was conducted into the immunisation of mice to a strain of
      Pasteurella multocida with pathogenicity for calf. Here are the findings: (a) The
      attenuation of Sm-id revertants was measured with reference to the order of
      extinction and compared to the wild strain. (b) A selected range of Sm-id
      revertants with differentiated attenuation is presented. (c) Single immunisation,
      using fully attenuatted Sm-d mutant does prevent lethal infection with partially
      attenuated Sm-id revertants, although it is ineffective against wild strain
      infection. (d) Immunity against 100 times the lethal dose of the wild strain can
      be achieved by two immunisations, that is primary antigen application, using
      fully attenuated Sm-d mutant, and booster immunisation, using partially
      attenuated Sm-id revertant.

PMID- 1020997
TI  - [Effect of Mecadox therapy on various organs of the reticulohistiocytary system
      in chickens].
AB  - Chickens received Mecadox treatment for 28 days, beginning at the age of five
      days, with the daily rations having been 1 g in 1 kg feedstuff. Changes were
      caused in two periods. The first therapeutic period, first to 14th days, was
      characterised by rise in total protein, DNA, RNA, amino nitrogen, and ascorbic
      acid in the adrenal gland as well as by rise in body mass, however, with no
      change of thymus and bursa mass. The second therapeutic period, between the 14th
      and 28 th days, led to decline in the above parameters and to involution of the
      lymphatic organs. The conclusion is suggested that biological stimulation can be
      achieved only in response to short-time Mecadox treatment.

PMID- 1020998
TI  - [Topography and cytoarchitecture of the diencephalon in the female comestic
      cattle (Bos taurus var. dom.)].
AB  - Ten brains of cows were, immediately after slaughter, embedded in celloidin,
      sliced, and stained to visualise neurocytes and nerve fibres, with the view to
      elucidating the structures of bovine diencephalon. Macroscopically, the
      diencephalon of cow is characterised by a comparatively strong epithalamic part,
      large laterally supported Corpora geniculata lateralis, pronounced ventricular
      bulgings, almost complete fusion of thalami with Massa intermedia, and very large
      pituitary gland. The five compartments of bovine interbrain are strongly
      developed and clearly delimitated by fibrous strings and platelets. By due
      consideration of the major fibre structures and cyto-architectonic
      characteristics, 62 nuclei may be differentiated in either half of the
      diencephalon, with 28 being situated in the thalamus and 23 in the hypothalamus.
      Two nuclear regions each were recordable from the epithalamus, metathalamus, and
      subthalamus.

PMID- 1020999
TI  - [Pathomorphologic changes in the ruminal acidosis of sheep].
AB  - Acute and subacute and spontaneous rumen acidosis was experimentally induced in
      20 sheep and two lambs after feeding of barley, maize or glycose. The inner
      organs of those animals then were examined for morphological changes. The changes
      recorded from experimental acidosis were analogous to those observed after
      spontaneous outbreaks. Hyperaemia and blood leakage were macroscopically observed
      underneath the rumen mucous membrane which could be easily pulled off. The same
      signs sometimes were manifest in the third and second stomach as well. Pronounced
      edemas and hyperaemia occurred in the lungs, meninges (pia mater), and brain, and
      blood leakage was recorded from the epicardium. The histological findings
      included epithelial desquamation, infiltration of lymphocytes and leucocytes into
      rumen and fourth stomach (subacute) hepatitis (in 60 per cent of all cases),
      physical degeneration in the kidneys, and focal myocarditis (in 50 per cent of
      all cases). There were hyperaemia, edematisation, and blood leakage in the lungs,
      perivascular and pericellular edema in the brain, and severe hyperaemia of the
      meninges (pia mater) and thyroid gland. Those morphological changes were
      persistent and characteristic. Their relevance to diagnosis of rumen acidosis in
      sheep is undenied, provided that due consideration is given at the same time to
      the case history and paraclinical indices.

PMID- 1021000
TI  - [Vaginal cytology studies on the determination of the onset of estrus cycle post
      partum in sheep].
AB  - State of vaginal cells and arborisation grade of cervical mucus were studied in
      364 Merino ewes of meat type from the 7. day ante partum. The Pundel modified
      Shorr-straining method and the Papanicolaou-straining method were used for
      differentiation of the cells (casal-, parabasal-, intermediate-and
      superficialcells). Near the 44., 54. and 70. day post partum a maximum of
      superficialcells and simultaneously a high grade of cervical mucus arborisation
      in elongating cyclic intervals can be observed in lactating ewes. In conclusion
      an early weaning of lambs between the 40. and 50. day post partum is considered
      to be in aggreement with cyclus.

PMID- 1021001
TI  - [Endocrine and spermatogenic testicular function. 9. Correlations between plasma
      testosterone and morphometric parameters of the testis in boars of different
      ages].
AB  - Close, statistically fully secured correlations were found to exist in boars,
      aged between four and four-a-half as well as seven and nine months, between the
      testosterone content in the blood of the V. spermatica interna, on the one hand,
      and morphometric parameters essential to quantitative sperm production, on the
      other (testicular volume, volume of germinativum, overall length of tubules,
      diameter of tubules, and cell density of the germinal epithelium).

PMID- 1021002
TI  - [Normal macroscopic and microscopic anatomy of the hemorrhoidal vascular system].

PMID- 1021003
TI  - [Macroscopic and microscopic changes in the haemorrhoidal vascular system in
      association with haemorrhoidal disease (author's transl)].

PMID- 1021004
TI  - [Anal cushions and the haemorrhoids (authors transl)].

PMID- 1021005
TI  - [Haemorrhoids and the genital life of the woman (author's transl)].

PMID- 1021006
TI  - [Predisposing agents liked to heredity and profession in haemorrhoids (author's
      transl)].

PMID- 1021007
TI  - [Aetiopathogenesis of haemorrhoidal thrombosis. The contribution of electron
      microscopy (author's transl)].

PMID- 1021008
TI  - Estrogens and endometrial cancer: aspects of etiology and survival rate.
AB  - With a clinical study it could be demonstrated, that the frequency of diabetes
      hypertension, estrogen effect in the vaginal smear and proliferative changes of
      the endometrium was significantly higher in patients with endometrial cancer than
      in a control group (p less than or equal to 0.001). Obesity was also
      significantly more frequent (0.02 less than p less than 0.01). In vitro studies
      demonstrated a significantly higher aromatization of androstendione to estrone in
      adipose tissue of endometrial cancer patients (p less than 0.01), indicating
      etiologic correlations between endometrial cancer and extraglandular estrone
      production. An additional clinical study indicated a better 5-years-survival rate
      if parameters, indicating endogenous estrogen effect were present.

PMID- 1021009
TI  - [Pharmacocinetic behaviour of alpha-L-arabinofuranosidase in therapeutical
      application to toxify transport forms of cancerostatic substances (author's
      transl)].
AB  - The present studies were carried out to obtain pharmacokinetic data about the
      elemination of intravenously administered alpha-Larabinofuranosidase from the
      blood stream and about the distribution and retention of the enzyme in different
      organs and in a transplantable sarcoma of mouse. The results were used for the
      planning of therapeutical experiments, in which detoxified transport forms of
      cancerostatic agents were to be toxified by exogenous enzymes specifically in the
      tumour tissue. The alpha-Larabinofuranosidase is eliminated from the blood
      circulation quite rapidly (half-life about 20 min); a large portion is apparently
      excreted through the kidneys. The distribution in the organs, as compared with
      the tumour tissue, is very favourable for the planned therapeutical experiments
      in relation to other enzymes: The enzyme is scarcely accumulated in the RES
      containing organs. In the tumour tissue, the enzymatic activity declines linerly
      with time of the experiment, while elimination of the enzyme from the kidney and
      muscle follows rather an exponential function. The optimal time interval between
      the enzyme and substate injections was determined to be 6 hrs.

PMID- 1021011
TI  - [Medical and biological applications of neutron beams of the impulse reactors IBR
      30 and IBR-2 (author's transl)].

PMID- 1021010
TI  - [Enzymologic investigations of Vx2-carcinoma transplanted into the stomach of
      rabbits (author's transl)].
AB  - Suspensions of V x2-carcinoma cells were inoculated into the stomach wall of
      rabbits. In 26 animals, changes of lactic acid hydrogenase (total activity and
      isoenzyme distribution) were followed from the transplantation day to complete
      development of a tumor. Findings were compared with mucosa specimen taken from
      different parts of the stomach. As compared with control animals (injection of
      physiological saline solution into the stomach wall), total enzyme activity was
      elevated and isoenzymes showed characteristic distribution in homogenisates from
      tumorous tissue. Mucosa covering the tumor did not reveal such alterations of
      enzyme activity. It can thus be concluded that V x2 carcinoma was limited to
      submucosal layers and did not invade the mucosa. This conclusion was confirmed by
      histologic examination.

PMID- 1021012
TI  - Effect of a Rauscher leukemia virus vaccine upon chemical oncogenesis in the
      mouse.
AB  - The concept that type-C RNA viruses serve as determinants of chemically induced
      cancer would be supported if immunization against such viruses reduced the
      incidence of methylcholanthrene-induced sarcomas. A formalin vaccine was employed
      which was able to protect mice against the development of virus-induced Rauscher
      leukemia: 8/12 vaccinated mice survived versus 1/12 controls. When mice so
      immunized were challenged with near-threshold doses of chemical carcinogen,
      sarcoma incidence and death latency did not differ between vaccinated and control
      groups: within 10 months, a 320 mug dose of methylcholanthrene induced 100%
      sarcomas in both groups, while a 64 mug dose induced 62% and 65% tumors in
      vaccinated and control mice respectively. Thus, a relevant postulate of the
      oncogene hypothesis could not be supported by these studies. Formalin treatment
      neutralizes the oncogenic effect of mouse leukemia viruses yiwlding preparations
      that are immunogenic and can be successfully used as vaccines to protect against
      virus-induced leukemia (5). The finding of murine leukemia viruses in chemically
      induced tumors (1, 2) poses the question of whether these viruses are present in
      the tumors as passengers, or whether they are etiologically involved in the
      process of tumor induction. An approach to answering this question would be to
      challenge with chemical carcinogens mice which have been vaccinated with leukemia
      virus. If the virus were somehow involved in tumor induction, antiviral
      immunization might conceivably interfere with chemical carcinogenesis. Whitmire
      and Huebner (9) have reported that mice immunized with formalin-treated leukemia
      viruses, become resistant to sarcomagenesis by methylcholanthrene. Repetition of
      this experiment by Gericke and Chandra (6) gave non-significant differences
      between experimental and control groups. The present paper deals with the effect
      of immunization against Rauscher leukemia virus upon tumor induction by near
      threshold doses of methylcholanthrene.

PMID- 1021013
TI  - [Determination of 3,4-benzopyrene-content in seeds before and after germination
      (author's transl)].
AB  - The content of 3,4-benzopyrene in various seeds before and after germination in
      different nutritive solutions is determined. The hygienic meaning of the results
      is discussed.

PMID- 1021014
TI  - [Evaluation of lymphography in neurologic complications of neoplastic diseases
      (author's transl)].
AB  - 1. By lymphographic examination, first of all, the primary and secondary tumours
      of the lymphatic system may be revealed and localized. Further on, it makes
      possible to state the stage of the disease and thus to apply the appropriate
      treatment. 2. In case of symptoms indicating that nerve-roots of unknown origin
      have been damaged, the result of lymphographic examination may call the attention
      to pathomechanism related to some tumour-disease. If the symptoms of the nervous
      system are caused by compression or infiltration of a tumour, most frequently the
      presence of pathologic lymph nodes in their surroundings can be revealed. 3.
      Among the patients of the National Oncological Institute, in 25 Hodgkin and 2
      cases pathologic filling of the lymphatic system was observed by lymphographic
      examination, -- in 4 cases in the surroundings affected by the damage of the
      spinal cord while in 23 cases in that of nerve-root. If a tumour disease is
      discovered and localized in time by lymphographic examination, the symptoms
      caused by it in the nervous system may be reduced, or, seldom, even alleviated,
      with a treatment of directed irradation combined with cytostatics. The favourable
      effect on alleviating pains is to be especially emphasised.

PMID- 1021015
TI  - An autoradiographic study of the mouse carotid body using tritiated leucine,
      dopa, dopamine and ATP with special reference to the chief cell as a paraneuron.
AB  - A comparative autoradiographic study on the uptake and intracellular localization
      of 3H-leucine-, 3H-dopa-, 3H-dopamine- and 3H-ATP-derived radioactivity was
      performed in the mouse carotid body to investigate the metabolic features of the
      chief cell as a paraneuron. 3H-leucine-derived radioactivity representing
      recently synthesized peptides was demonstrated in all kinds of cells in the
      carotid body and surrounding area. The chief cell was less radioactive than the
      nerve cell in the superior cervical ganglion. In the electron microscope
      autoradiography, no accumulation of radioactivity could be demonstrated either in
      the Golgi area of the chief cell, where the membrane-bound particles were
      probably formed, nor in the periphery of the cells, where they were stored before
      their release. Incorporation of 3H-dopa-derived radioactivity representing
      recently synthesized catecholamines was specific to the chief cell, mast cell,
      and nerve cell in the superior cervical ganglion. In the chief cell the
      distribution of radioactivity was roughly identical with that of the large dense
      cored vesicles. Striking accumulations of 3H-dopamine-derived radioactivity were
      demonstrated in the adrenergic nerve terminals in the perivascular space and the
      glomus complexes of the carotid body. Not all of the chief cells incorporated the
      3H-dopamine-derived radioactivity. 3H-ATP derived radioactivity was demonstrated
      in all kinds of cells in the carotid body and surrounding tissues. In the chief
      cell, as in other kinds of cells, the highest radioactivity was seen in the
      nucleus. The present results suggest that, if the large dense-cored vike those
      membrane-bound particles in other paraneurons, contain peptides, monoamines and
      ATP, the turnover of these products as secretory materials is much slower in this
      cell than in such endocrine paraneurons as adrenal chromaffin cells and gut
      endocrine cells.

PMID- 1021016
TI  - Double afferent arterioles of the rat renal glomerulus as studied by the
      injection replica scanning electron microscopic method.
AB  - One thousand eight hundred and fifty-six specimens of replicated rat renal
      glomerulus were examined under the scanning electron microscope, and an extremely
      rare anomaly of the glomerulus with double afferent arterioles was described. The
      double afferent arterioles arose separately from a terminal twig of the
      interlobular artery and reached the vascular pole of a subcapsular glomerulus
      which possessed a single efferent arteriole. Microdissection revealed that this
      glomerulus was composed of three fairly independent lobules of anastomosing
      capillaries. Microdissection also revealed that the double afferent arterioles
      were isolated from each other even in the glomerulus: the one supplied two
      lobules, while the other the third one only.

PMID- 1021017
TI  - On the periodically aggregated particles on the fracture face of the cochlear
      hair cell.
AB  - By means of the freeze-fracture technique, the membrane specialization of the
      cochlear hair cell of guinea pigs was studied. Periodically aggregated particles
      were revealed on the PF face of the plasma membrane of the outer hair cell. The
      particles were around 12 nm in diameter and 10 to 17 nm in center-to-center
      spacing. Their arragement was hexagonal, orthogonal or parallel. Possible
      involvement of this structure in the electrical excitability of the membrane was
      discussed.

PMID- 1021018
TI  - Intercellular secretory canaliculi in the feline laryngeal gland.
AB  - Laryngeal glands of adult cats were observed by scanning electron microscopy.
      Intercellular secretory canaliculi in the gland were an arborized system of
      capillaries extended among acinar cells, and their stem or collecting canaliculus
      opened to the gland lumen. The inner surface of the canaliculi was provided with
      small globular microvili. The canaliculi in the laryngeal gland resembled the
      hepatic bile capillaries in lower vertebrates.

PMID- 1021019
TI  - [New types of chromones].

PMID- 1021020
TI  - [Condensation of 2-hydroxyacetophenone derivatives to Mannich bases with 4
      chromanones].

PMID- 1021021
TI  - [Nitrones. 7. Synthesis of an isoxazoline by dimerization of a C-methylnitrone].

PMID- 1021022
TI  - [The structure of "diphenylhydantil"].

PMID- 1021023
TI  - [Stereo-controlled synthesis of 4-thiageranic acid ethyl ester].

PMID- 1021024
TI  - [Colloidal, partition and binding properties of phenothiazine derivatives, V:
      Relationships between albumin binding and physical properties (author's transl)].

PMID- 1021025
TI  - [Beta-substituted enamines. 8. Fused ring systems from 2-aminoheterocycles and
      derivatives of alpha-chloroacetoacetic acid].

PMID- 1021026
TI  - [Beta-substituted enamines, IX: Reactions of 8-aminoquinoline with derivatives of
      alpha-chloroacetoacetic acid (author's transl)].

PMID- 1021027
TI  - [1,4-pentadien-3-ones, XI: Reactions of dialkyl ketones with aromatic aldehydes
      (author's transl)].

PMID- 1021028
TI  - [Bicyclic alpha-amino acids, I: Preparation of 3-(1-naphthyl)-alanine by
      catalysed reductive amination (author's transl)].

PMID- 1021029
TI  - [Reactions of phenyl substituted barbiturates in concentrated sulfuric acid
      (author's transl)].

PMID- 1021030
TI  - [The rate of the in vitro dissolution of microencapsulated acetylsalicylic acid
      (Colfarit) in relation to the ethanol content of the dissolution medium (author's
      transl)].

PMID- 1021031
TI  - [Tetrahydrobenzodipyrandiones and tetrahydrobenzodipyrans (author's transl)].

PMID- 1021032
TI  - [The idenification of phenylubtazone (author's transl)].

PMID- 1021033
TI  - [The mechanism of the reaction of anthranil amide with lactones (author's
      transl)].

PMID- 1021034
TI  - [1,2,3,4,5-Pentahydro-2-oxo-pyrido(3,2B)azepines via Schmidt reaction on 1-aza-5
      oxo-tetralines (author's transl)].

PMID- 1021035
TI  - [Syntheses of heterocycles, 184. The synthesis of kawalactone derivatives
      (author's transl)].

PMID- 1021036
TI  - [On the role of the beta-hydroxy group of atropine for specificity and duration
      of the antimuscarinic action, I: Synthesis of homologous series of new atropine
      analogues (author's transl)].

PMID- 1021037
TI  - [Investigations on some p-substituted phenylsulfonamido-derivatives (author's
      transl)].

PMID- 1021038
TI  - [Reactions of alkyl substituted N-methoxypyridinium salts with secondary
      aliphatic amines in dipolar aprotic solvents (author's transl)].

PMID- 1021039
TI  - [Pyrrolo (2,3-B)pyridine].

PMID- 1021040
TI  - [Barbituric acid derivatives. 21. correlation of methylhexital with
      methylcyclobarbital].

PMID- 1021041
TI  - [The mechanism of the Jaffe reaction with creatinine].

PMID- 1021042
TI  - Modifications in the epidemiological evolution of some serotypes of Salmonella.

PMID- 1021043
TI  - Taxonomical relationships Klebsiella-Enterobacter investigated by means of phage
      bacteria systems.

PMID- 1021044
TI  - Unusual and new Leptospira hebdomadis serotypes isolated from wild small rodents
      in Romania.

PMID- 1021045
TI  - The fine structure of Toxoplasma gondii endozoids. The existence of an
      endocytosis mechanism.

PMID- 1021046
TI  - Toxoplasma gondii--host cell interaction. Ultrastructural aspects of the parasite
      penetration mechanism.

PMID- 1021047
TI  - Temperature-sensitive mutant of a tetracycline resistance staphylococcal plasmid.

PMID- 1021048
TI  - [3 cases of ocular candidiasis caused by Candida lipolytica].

PMID- 1021049
TI  - [Septicemia in children according to autopsy data].
AB  - Analysis of section material was carried out covering the period 1943-1975. It
      was established that proportion of septic diseases in the general structure of
      children's mortality in the recent years was stabilized at rather high levels
      (1973-1975--17.1%). Fatal outcomes were most often among infants at the early
      period of life in whom sepsis developed against the background of premorbid
      factors including prematurity, malformations, pathologic labour, mother's
      diseases, etc. The course of sepsis was particularly severe in infants with
      congenital immunodeficient states. The main pathogene of sepsis at present is
      staphylococcus. During the period under study, correlation and morphology of
      various forms of sepsis varied depending upon the pathogene and therapy applied.
      Since 1968 and up to new the most common form of sepsis has been that
      morphologically identical to sepsis observed in 1943-1947, i.e. before the wide
      application of antibiotics.

PMID- 1021050
TI  - [Characteristics of umbilical septicemia in premature infants].
AB  - An analysis of 60 deaths of premature infants with umbilical sepsis revealed a
      number of peculiar features of this disease under current conditions:
      septicopyemia with a fatal outcome in the perinatal period in intrauterine
      infection, predominance of productive inflammation in the primary focus in
      infants with septicemia, the effect of acute respiratory diseases on clinico
      morphological manifestations of sepsis and its complications, frequency of
      ulcerative lesions of the intestine against  the background of antibiotic
      therapy.

PMID- 1021051
TI  - [Basic trends and perspectives of development of Soviet pathological anatomy of
      childhood diseases].
AB  - The article deals with the main trends in scientific investigations in the field
      of pathological anatomy of diseases of childhood in the USSR. New data are
      presented on respiratory infectious diseases in children, pneumonias, serum
      hepatitis, meningococcal infection, immunodeficit states, nephrology,
      gastroenterology, pathology of therapy of tumours and leukemias, perinatal
      pathology. The main trends of further research in the field of infectious
      pathology, immunopathology, lesions of the central nervous system and the
      microcirculatory bed in children, tissue defects and diseases in fetus associated
      with late toxemia in mothers are suggested.

PMID- 1021052
TI  - [Routes of arteriovenous shunting of blood in chronic venous insufficiency of the
      lower limbs].
AB  - Morphological studies of the mechanisms of arterio-venous shunting of the blood
      occurring in the lower extremities in varicose and postthrombic lesions of veins
      were carried out. Studies of the subcutaneous tissue, superficial and binding
      veins, skin, fasciae, lymphatic nodes, skeletal muscles resected in the course of
      152 radical operations in connection with varicose and postthrombic afflictions,
      showed that in the paravasal tissue of varicose veins and in the sclerosing
      subcutaneous tissue of the crus anastomoses of the obturator artery type
      developed. Their formation was connected with compensation of the regional
      circulation rate due to atrophy of capillary networks in the process of
      sclerosis. Moreover, a pathological arterio-venous discharge may also take place
      in the course of organization of thrombosis and origination of the communication
      between trophic vessels of the wall and the lumen of the recanalized vein. These
      findings should be considered in selecting a therapeutic strategy in chronic
      venous insufficiency of the lower extremities.

PMID- 1021053
TI  - [Characteristics of the terminal segments of the lymphatic system of
      microcirculation according to the data of scanning electron microscopy].
AB  - Lymphatic capillaries and postcapillaries in the system of the connective tissue
      were studied by the method of scanning (raster) electron microscopy. It was shown
      that these capillaries consisted of chains of ballon-shaped structures-sinuses.
      Lymphatic capillaries represent an open system which is communicated with the
      intercellular matter of the connective tissue by means of openings ensuring
      filtration of the tissue liquid. Impairment of the absorbing function in the
      fibrous process in the lungs led to deposition in connective tissue cells of
      cellular detritus and foreign particles with formation around the walls of
      lymphatic capillaries and postcapillaries of residue-collector zones. Overgrowth
      of a rough fibrous tissue around these zones brought about atrophy and
      obliteration of vessels, gradual attenuation of the drenage function in the given
      region of microcirculation.

PMID- 1021054
TI  - [Dynamics of "reverse development" of dystrophic changes in the epithelium of the
      fundal gastric glands].
AB  - Electron-microscopy investigations of the gastric mucosa in 23 patients at
      various periods following the cessation of the course of a therapeutic fasting
      diet lasting 20-30 days were carried out. It was shown that oxidation of
      infiltrative lipids in cover cells and elimination of a great number of residual
      bodies accumulated in the process of fasting and representing a morphologic
      manifestation of fat dystrophy, proceeded very intensively and completed in 2
      days after the start of taking food. Purification of cells developed mainly in
      the direction opposite to that of elimination of secretion products. Myelin
      figures (residual bodies of cytolysosomas) which were to be eliminated from the
      cell, escaped into the lumen of broadened intercellular spaces and passing along
      them they reached the basal parts of the cell, then they pass through the basal
      membrane into lamina propia of the stomach mucosa and penetrate through the
      capillary wall into the vascular bed. Restoration of the normal ultrastructure of
      the secretory cells is a lengthy process and it finishes, depending upon the
      individual feature of the organism, on the 15-20th day from the start of taking
      food.

PMID- 1021055
TI  - [Cytology and enzymocytochemistry of nodose hyperplasia and cancer of the
      prostate].
AB  - In cytological investigations the following forms of cancer of the prostate may
      be verified: differentiated (clear-cellular and dark-cellular adenocarcinoma);
      poorly differentiated; and nondifferentiated (microcellular and polymorphic
      cellular cancer). In the unchanged epithelium of the prostate there was noted a
      high activity of acid phosphotase, nonspecific esterase, nonspecific 5'
      exonuclease, acid RNA-ase, acid DNA-ase, leucine aminopeptidase, and the absence
      of activity of alkaline phosphotase, neutral DNA-ase, alkaline RNA-ase. In the
      cancerous epithelium the activity of leucine aminopeptidase was either
      drastically decreased or absent altogether; the activity of acid DNA-ase and acid
      RNA-ase was non-uniform with the tendency to decrease in poorly differentiated
      tumours. The activity of other investigated enzymes in the cancerous epithelium
      showed no significant changes. At early stages of development of squamous cell
      metaplasia in the epithelium there was identified alkaline RNA-ase dissapearing
      in manifested metaplastic changes.

PMID- 1021056
TI  - [Morphofunctional characteristics of male gonads in cancer of different
      localization].
AB  - Morphological and histochemical changes in the genital organs in 62 men, who had
      died of cancer of various localizations, and those in the testes in 65
      practically healthy men aged 30-90 years, who had died of various causes,
      (controls), were studied. The studies conducted showed that changes in the male
      gonads in cancer of various localizations were similar to involutional ones, the
      former, however, were more pronounced and occurred in younger men. It was
      established that the functional activity of granulocytes in cancer
      dropped,whereas the activity of sustentocytes remained at a high level. This was
      one of the causes of impairment of the hormonal balance in the organism of a
      patient, cancer carrier, and of inhibition of the spermatogenesis activity. The
      degree and depth of changes depended on the stage and duration of the disease,
      localization of tumours was of no significance.

PMID- 1021057
TI  - [Causes of death of patients with breast cancer (according to the materials of
      the Oncological Research Center of the USSR AMS for the period 1953-1975)].
AB  - The article presents results of investigations of 207 case records and protocols
      of autopsies of deceased patients who suffered from breast cancer, covering the
      period from 1953 to 1972 (materials of the USSR AMS Oncological Research Centre).
      It was established that in 154 patients (74.4%) the cause of death was the
      progress of the main disease, the most common and "typica" causes of death being
      pulmonary-cardiac, renal insufficiency (as a result of metastatic lesions of the
      above mentioned organs) and complications associated with metastases of breast
      cancer in to the brain and its meninx. In 39 patients (18.8%) the cause of death
      was directly associated with therapy complications, 14 patients died of diseases
      not connected with carcinoma of the mammary gland. The structure of causes in the
      group of deceased patients who when alive suffered from cancer of the mammary
      gland and who survived 10 and more years from the moment of establishing the
      diagnosis and carrying out primary treatment (11 observations) was found to be
      the same as that for the whole group of observations.

PMID- 1021058
TI  - [Morphogenesis of cytoplasmic inclusions in influenza].
AB  - Morphogenesis of cytoplasmic inclusions was studied in experimental influenza
      infection in white mice. It was shown that cytoplasmic inclusions in influenza
      represented foci of partial degeneration and necrosis of the cytoplasm, the
      developmental phases of which are similar to phases of formation by means of
      autolysis. The disintegration of the content of inclusions in the epithelial
      cells of the bronchi was accompanied by accumulation in their zone of enzyme
      containing structures of the type of tegmented vesicles. In low delimitation of
      inclusions odema of cyto- and karyoplasm was followed by destruction of
      mitochondria and perish of the cell. Formation of inclusions and signs of
      reproduction of the virus in alveolar cells proceeded with destruction of
      osmiophilic bodies. The processes of delimitation of inclusions in cytoplasm was
      of a reactive character and contributed to preservation of the life activity of
      cells.

PMID- 1021059
TI  - [Pathological anatomy of Edwards' syndrome (trisomy 18)].
AB  - Data of the literature (200 section observations) and those of 10 authors' own
      observations on the syndrome of trisomy with relation to chromosome 18 are
      presented. The pathologoanatomic diagnosis of Edwards' syndrome can be
      established without an investigation of chromosomes on the basis of a complex of
      congenital defects present in the newborn. The main of them are: prenatal
      hypoplasia, dolichocephaly, microgenia, concha auriculae drawn in the horizontal
      plane, flexor position of bones, shortness and thickness of the great toe and
      protruding heel, thickness and distortion of convolution of the dorsal lip of the
      olivary nucleus, hypoplasia of the cerebellum, heterotopia of the piriform
      Purkinje cells into the white matter of the cerebellum and foci of
      nondifferentiated cells in the white matter of the great hemispheres; complex
      cardiac defects--Meckel's diverticulum, fused kidneys (horseshoe- or L-shaped)
      with small cysts in the renal cortex; and the presence of 10 or more arches on
      fingers and toes in combination with proximal or intermediate localization of
      axial triradius.

PMID- 1021060
TI  - [Mechanisms of intestinal bacterial toxemia in severe burns].
AB  - Electron-microscopy investigations of the small intestine mucosa in white rats
      with deep thermal burns of 18-20% of the body surface showed that already in
      early periods following the trauma grave thermal burns caused structural
      desorganization of the enterocytic barrier and invasion of the intestinal
      microflora. Damages of the wall of capillaries of the small intestine mucosa,
      being in themselves manifestations of generalized lesion of the histo-hematic
      barriers in burns, contributed to further invasion of microflora and its vital
      activity products into the blood. During the investigation a morphological
      picture of the phenomenon of endotoxinemia and bacteriemia developed already in
      the early periods of the burn trauma was established.

PMID- 1021061
TI  - [Fetal and neonatal asphyxia].
AB  - The literature data and the author's own observations justify the conclusion that
      asphyxia of the fetus and newborn is the most common cause of death in the
      perinatal period. The author discusses the significance of asphyxia of the fetus
      and newborn as the main disease or the principal cause of death. The author
      suggests that the type of asphyxia of the fetus or newborn in every concrete case
      should be indicated in the pathologoanatomic diagnosis on the basis of physiology
      of intrauterine and extrauterine life. In case of asphyxia it is suggested that
      the question concerning the presence (or absence) of the underlying disease-
      fetopathy, pre-existing the asphyxia condition--should be considered. In case of
      asphyxia of the newborn the author recommends to bear in mind the anatomic
      substrate responsible for impairment of the act of breathing of the newborn. In
      most cases this substrate is represented by pneumopathies--noninflammatory
      changes in the lungs of the newborn. Pneumopathies of the newborn include deep
      aspiration of the amniotic content, atelectasis, edema and hemorrhages, hyaline
      membranes.

PMID- 1021062
TI  - [Relationship between the epithelium and connective tissue at different stages of
      healing of chemical burns of the esophagus].
AB  - The interaction between the epithelial and connective-tissue structures was
      studied on 70 scarry changes in the oesophagus at various times (from 1 year to
      45 years) following chemical burns. As sclerotic alterations progressed,
      proliferation of the layers of the stratified squamous epithelium decreased,
      which was particularly evident in the zones of strictures of the lumen of the
      damaged oesophagus. Exacerbation of inflammation due to repeated traumatization
      of the oesophagus wall was accompanied by proliferation of the epithelial layers.
      Only 25-30 years after the burns in the proliferative layers of the epithelium
      there were noted signs of atypia. The chronic inflammation was accompanied by
      marked lympho-plasmocytic infiltrations. This may indicate to concomitance of
      chronic oesophagitis with manifestations of autoimmune reactions.

PMID- 1021063
TI  - [Comparative morphological characteristics of adenoacanthoma of different
      localization].
AB  - A morphological analysis of 40 observations on adeno-acanthomas of different
      localizations (oesophagus, uterus, larynx, pharynx) is presented. It was
      established that adeno-acanthoma, which is characterized by two-component
      composition, distinguished itself by certain variability of the structure. The
      plano-epithelial component present in the tumour of the glandular structures may
      be of a different degree of maturation, may have the structure of planocellular
      cancer, or may have no signs of atypia. Basing on their own findings and data
      reported in the literature the authors come to the conclusion that adeno
      acanthomas depending on their structures should be referred to differently: adeno
      acanthoma and adenosquamous cancer. It is possible that morphological differences
      in the histological structure of adeno-acanthoma are of significance in the
      clinical course of the disease.

PMID- 1021064
TI  - [Certain results of training of physicians-pathologists through internship].
AB  - The article discusses the experience in the post-graduate training of medical
      personnel in pathological anatomy in internship organized at the centralized
      prosectorium of the Poltava Regional Clinical Hospital. The Base has been found
      to fulfil its task quite satisfactorily. The centralized prosectorium has been
      serving a hospital fund amounting to 2755 beds. Annually, over 700 autopsies and
      30 000 investigations of operative, bioptic and section materials are being
      performed in the prosectorium. A close contact of the regional specialist with
      the regional (oblast) public health department and his personal participation in
      the oppointment of medical graduates as prosectors are of importance in adequate
      staffing of medical institutions with prosectors.

PMID- 1021065
TI  - [Endometrial polyp transformed into carcinosarcoma].
AB  - A case of polyp of the endometrium in a female patient, 52 years of age, with
      malignization of both the stroma and the glandular component, is described.
      Planocellular metaplasia of the epithelium of the glands with its marked
      proliferation, dystrophic changes, buried growth of the type of adenoacanthoma
      were observed. The stroma was characterized by overgrowth of polymorphic spindle
      shaped cells with the presence of mitosis figures. The general picture of
      sarcocarcinoma was observed. A favourable 4-year catamnesis was established.

PMID- 1021067
TI  - [Craniopharyngioma].

PMID- 1021066
TI  - [Focal dysplasia of the kidney].

PMID- 1021068
TI  - [Remodeling of the rotation microtome for preparation of semi-thin sections].

PMID- 1021069
TI  - [Device for microscopes for determination of exposition in microphotography].

PMID- 1021070
TI  - [Phonocardiographic study of the 3rd sound].

PMID- 1021071
TI  - Fourteen year cardiological follow-up of patients with initially known livels of
      low density lipoproteins. II. Correlation between high serum levels of low
      density lipoproteins and early death from myocardial infarction.

PMID- 1021072
TI  - [Familial paramyloidotic cardiomyopathy. Hemodynamic and cineangiocardiographic
      study].

PMID- 1021073
TI  - [Echocardiography. Methods and normal values].

PMID- 1021074
TI  - [Diminishing of the infarct area by using an intra-aortic balloon: metabolic and
      electrocardigraphic study].

PMID- 1021075
TI  - Conotruncal syndromes: anatomo-pathological characterization.

PMID- 1021076
TI  - [Indication and methodology of hemodynamic study in intensive care units. I].

PMID- 1021077
TI  - [The use of a blood filter during extracorporeal circulation. Analysis of the
      behavior of platelets. Preliminary results].

PMID- 1021078
TI  - [Experience in 776 patients with a dura mater valve].

PMID- 1021079
TI  - The endocrinologist--what is his role.

PMID- 1021080
TI  - Hormones in therapy: an overview.

PMID- 1021081
TI  - Drugs which cause diabetes.
AB  - It is clear from this review that a number of drugs, some of them in widespread
      use, may have as a side effect a diabetogenic action. Whether this effort occurs
      when there is no underlying genetic predisposition to diabetes is, at this stage
      in our knowledge, hard to determine. However, at a time when the incidence of
      diabetes mellitus is rising steadily in our community, any potential cause for
      even a proportion of such cases must be seriously considered. Whether at some
      stage in the future it will be possible to determine either on a genetic profile,
      or on a pharmacological profile those patients who are likely to develop such
      side effects, is yet to be seen. Meanwhile, a constant vigilance towards our
      patients treated with these drugs is required, and a readiness on the part of the
      physician to arrange the appropriate investigations, and where necessary to
      rearrange therapy, is essential.

PMID- 1021082
TI  - The problem of hirsutism in women.
AB  - Women commonly complain of excess facial or body hair. There are generally no
      other abnormal physical findings and the relevance of other symptoms, especially
      those related to the menstrual cycle, may be unclear. The theme of androgen
      excess provides an explanation for the sign and various symptoms, and suggests
      certain pathology. Rational therapy can be based on and understanding of the
      hormonal processes involved in the development of secondary sexual hair.
      Treatment of simple hirsutism is well tolerated even in prolonged courses, and in
      most cases produces a satisfactory cosmetric result.

PMID- 1021083
TI  - Insulin --- problems and syringes.

PMID- 1021084
TI  - The thorough overhaul.

PMID- 1021085
TI  - Examination of some processing methods for freezing boar semen.
AB  - Five experiments were conducted to examine the effect of processing methods and
      diluents on survival and morphology of boar spermatozoa after freezing. Post
      thawing survival of spermatozoa was better for Beltsville-F3 (BF3) than for tris
      fructose-EDTA freezing diluent when the seminal plasma and glycerol were removed
      prior to freezing (method A). Both freezing diluents yielded similar viability
      results when the spermatozoa were frozen in the presence of siminal plasma and
      glycerol (method B). Viability of spermatozoa after thawing was better when
      glycerol concentration in the prefreezing diluent (method A) or in the freezing
      medium (method B) was 2-5 and 5-0 rather than 7-5%. Cooling of diluted semen to 5
      degrees C beyond 4 h decreased the post-thawing survival of spermatozoa. The
      proportion of spermatozoa with undamaged acrosomes after processing and thawing
      by different methods was indistinguishable and relatively low. When the semen was
      frozen at cell concentrations ranging from 0-25 to 2-0 X 10(9)/ml, the viability
      of spermatozoa declined with increasing concentration following freezing in BF3,
      and S-1 diluents. Viability results were very similar for all cell concentrations
      examined when tris-fructose-EDTA diluent was used, indicating the possibility of
      freezing boar semen in a concentrated state.

PMID- 1021086
TI  - Fertility test of frozen boar semen.
AB  - The fertility results of two experiments are presented. In experiment 1, the
      semen was frozen in tris-fructose-EDTA or BF3 diluents at 0-25 X 10(9)/ml sperm
      concentration and extended after thawing with either seminal plasma (SP) or the
      freezing medium (FM) containing no cryoprotective agent. In the second experiment
      the semen was glycerolated by two methods, frozen at 1-0 X 10(9)/ml sperm
      concentration, and extended wtih FM before insemination. Fertility after double
      insemination within one oestrus with semen frozen in tris-fructose-EDTA or BF3
      diluents varied depending on the medium used for extension of thawed semen. The
      farrowing rates for semen frozen in the former diluent with FM and SP post
      thawing media were 4/8 and 1/8 respectively, and for semen frozen BF3 diluent
      with FM and SP post-thawing extenders 1/8 and 5/8. The mean farrowing for the 32
      animals inseminasted was 34-4%. Pregnancies for semen frozen in tris-fructose
      EDTA and glycerolated at 30 or 5 degrees C were 5/12 and 4/12 respectively, and
      for single and double inseminations 6/12 and 3/12 respectively. Of 24 animals
      inseminated 37-5% farrowed.

PMID- 1021087
TI  - Effects of semi-starvation on the total body composition and absorptive function
      of the small intestine of the young adult female rat.
AB  - Sixteen female rats aged about 80 days and with a mean body weight of 175 g were
      fed 40% of their ad libitum intake of a laboratory chow. They were killed and
      analysed for water, protein, lipid and ash after 9, 21-5, 30-2 and 38-8% of body
      weight had been lost. Compared to a control group of four animals, the 38-8%
      group lost 13 g or 34% of their protein. The animals in the 21-5, 30-2 and 38-8%
      groups lost 7-5 g or 87% of their lipid leaving only 1-1 g of lipid. The
      percentage protein in the body was little affected by body weight loss but lipid
      decreased from 5 to 1%. In another experiment with 26 rats of 205 g mean body
      weight and aged about 115 days, absorption rates by the small intestine were
      measured in vivo after variable weight losses between 0 and 39%. D(+)-Glucose
      uptake was increased by about 70% in those animals which had lost only 5% of body
      weight and this increased uptake was retained in those rats which had lost up to
      39% of body weight. The absorption of L-leucine was not affected by the decline
      in body weight compared to the controls but relative to body weight, the ability
      of the intestine to absorb increased. In the same animals, the wet and dry
      weights of the small intestine declined slightly faster than body weight and the
      length of the small intestine tended to decrease slightly with increasing loss of
      body weight.

PMID- 1021088
TI  - Effect of electrical stimulation of the vagus nerves on bile secretion in
      Anaesthetized sheep.
AB  - Bile was collected before and during electrical stimulation of the vagus nerves
      in acute experiments on sheep with ligated cystic ducts. Most stimuli caused no
      change in bile formation, but a 10-V, 10-Hz stimulus caused a slight increase in
      bicarbonate output. Neither the response to infused secretin nor the maximum rate
      of bile salt transport by liver cells changed during vagal stimulation. It was
      concluded that the vagal innervation of the liver is not likely to play a major
      role in the regulation of bile formation in sheep.

PMID- 1021089
TI  - The relation between Z--disk lattice spacing and sarcomere length in sartorius
      muscle fibres from Hyla cerulea.
AB  - Sartorius muscles from the green tree frog Hyla cerulea were set at variety of
      muscle lengths and fixed for electron microscopy using acrolein followed by
      osmium tetroxide. The sarcomere length, s, was determined in thick sections using
      laser-diffraction. The Z-disk lattice spacing, z, was measured in electron
      micrographs of thin sections from the same muscles. The Z-disk lattice was found
      to expand as sarcomere length decreased such that the quantity sz2 was constant
      at 1-05 X 10(6) nm3 for all sarcomere lengths in the range 1-9-2-9 mum. Thus, the
      sarcomere length dependency of the Z-disk lattice is similar to that of the
      myosin filament lattice. The density of thin filaments per unit cross section of
      fibril leaving the Z-disk is less than their density in the A band. Thus, fibrils
      have a smaller cross section in the I band, leaving more inter-fibrillar space
      there. This may explain why more mitochondria and lipid droplets are located in
      the I bands than in the A bands. It is suggested that the Z-disk may contributed
      to the short range elasticity of muscle fibres.

PMID- 1021090
TI  - Eperythrozoon ovis: the difference in carbohydrate metabolism between infected
      and uninfected sheep erythrocytes.
AB  - The glucose utilization lactic and pyruvic acid production and oxygen uptake of
      normal and Eperythrozoon ovis infected sheep erythrocytes were measured under
      aerobic conditions. Infected cells showed marded increases in both glucose
      utilization and acid production as compared with controls. Uninfected erythocyte
      samples which included a percentage of reticulocytes comparable to that found in
      E. ovis infection showed no apparent difference in glucose utilization and lactic
      acid production form the normal control erythrocytes, although considerable
      increases in the oxygen uptake were recorded.

PMID- 1021091
TI  - The influence of adrenergic nerves of the response of blood vessels in the rabbit
      ear to 2--phenylalanine-8-lysine vasopressin (Octapressin).
AB  - The blood vessels in the rabbit ear have been used to investigate the effects of
      octapressin on vascular smooth muscle. Continuous administration of this drug
      resulted in tachphlatis. Cocaine enhanced the response of the ear to octapressin;
      however, this potentiation was not evident when phentolamine was concurrently
      added to the perfusate. Denervation and reserpinisation of the ear also
      eliminated the potentiation of octapressin's response by cocaine. The results
      suggest that there is a small, indirect sympathomimetic component involved in
      octapressin's action on the vasculature.

PMID- 1021092
TI  - Prostaglandin in the saliva of the cattle tick Boophilus microplus.
AB  - Previous studies of saliva from engorged female cattle ticks revealed a component
      which induced contration of some isolated smooth muscles. Fractionation and
      further characterisation have shown that this substance is of the "slow-reacting"
      type, but that it is neither a bradykinin nor slow-reacting substance of
      anaphylaxis. The substance is deactivated by incubation with 15
      hydroxprostaglandin dehydrogenase and its pharmacological properties also support
      its classification as a prostaglandin. A second pharmacologically-active
      component has now been found in the saliva but has not yet been characterised.

PMID- 1021093
TI  - Ord River arboviruses--serological epidemiology.
AB  - This paper presents the results of haemagglutination-inhibition tests carried out
      on sera from 441 persons, 1,080 cattle and 335 birds in the Kimberley area. Two
      Alphaviruses (group A) (Ross River and Sindbis) and one Flavivirus (Murray Valley
      Encephalitis) were used for the preparation of haemagglutinins in the
      haemagglutination-inhibition tests. The tests showed a high percentage of
      antibody of Murray Valley Encephalitis in humans, birds and cattle, with an
      obvious focus of infection in the study site when cattle sera from different
      geographic areas were compared. These results are discussed in relation to the
      evolution and ecology of arboviruses in the Ord River area.

PMID- 1021094
TI  - Childhood accidents.

PMID- 1021095
TI  - Familial juvenile nephronophthisis: report of a case including microdissection
      studies.

PMID- 1021096
TI  - Assessing obstructive airways disease in children. Which test is best?

PMID- 1021097
TI  - Ventilatory disturbance in children with obstructive lung disease.

PMID- 1021098
TI  - The problem asthmatic: some significant perinatal factors.

PMID- 1021099
TI  - Facts and fallacies in a sociological study of asthma.

PMID- 1021100
TI  - A 20-year follow-up of children with a partial thoracic stomach (hiatal hernia).

PMID- 1021101
TI  - Comment on the diagnosis of inborn errors of metabolism in Australia.

PMID- 1021102
TI  - Autoantibodies, immunoglobulins and hepatitis B antigen in children with chronic
      liver disease.

PMID- 1021103
TI  - Tasmanian infant feeding survey, 1974.

PMID- 1021104
TI  - Nutrition: a problem for paediatricians.

PMID- 1021105
TI  - Undernutrition in the midst of plenty: nutritional problems of young Australian
      aborigines.

PMID- 1021106
TI  - Some shortcomings in human nutrition in Australia.

PMID- 1021107
TI  - Nutrition: a problem for more than paediatricians.

PMID- 1021108
TI  - Some unanswered questions about childhood obesity.

PMID- 1021109
TI  - The role of wild animals in the spread of exotic diseases in Australia.
AB  - The distributions of the following feral animals are given -- cattle, buffalo,
      pig, goat, deer, camel, horse, donkey, fox, dog and cat -- and the native dingo.
      The possible role these and the native rodents, marsupials and monotremes would
      play should an exotic disease of livestock enter Australia is discussed. It is
      considered that feral animals would be important in creating foci from which the
      disease would spread.

PMID- 1021110
TI  - Relationships between heart score, heart weight and body weight in Greyhound
      dogs.
AB  - The aim of this study was to determine the relationships between heart score
      (mean QRS interval), heart weight and body weight in Greyhound dogs. Highly
      significant correlations between these measurements have been observed and
      distinct sex differences have been demonstrated. The results of multiple
      regression analysis indicated that 66% of the variation in heart weight was due
      to variation in heart score and body weight. From the regression analysis, a
      formula for heart weight prediction with a standard deviation of 27.1 g was
      derived. The implications of these findings have been discussed briefly and
      emphasis has been placed on the need for good electrocardiographic technique, if
      the procedures outlined are to be used successfully. The positive correlation
      between heart score and heart size demonstrated here in Greyhounds is in accord
      with similar correlations reported previously in racehorses and human athletes.

PMID- 1021111
TI  - Artificial insemination of beef cattle.
AB  - A system for the artificial insemination fo beef cattle was described. The system
      involved preparation of the cattle and facilities, visual oestrous detection
      twice a day, drafting each morning and insemination of oestrous cows twice a day.
      The AI program was evaluated during the course of the program and at pregnancy
      test 35 to 90 days after the end of the insemination period. The insemination
      period was from 25 to 60 days depending on efficiency, with programs from 25 to
      35 days being favoured. Results for 12218 first inseminations (65.9%) and 2222
      second inseminations (57.8%) in 56 AI programs compared favourably with results
      in dairy AI. Pregnancy rates in lactating cows (70.5%) were significantly higher
      than in nonlactating cows and heifers (66.1%). Overall efficiency of well-managed
      AI programs were represented by 63% of cows put into a program becoming pregnant
      in a 29-day insemination period. Seventy-two per cent of the cows put into the
      program were inseminated yielding an 88% pregnancy rate. The efficiency of visual
      oestrous detection was 95% but this estimate did not include false positives.
      Efficiency of AI programs were effected by management, nutrition, infection,
      inseminators, facilities and the origin and type of cattle put into a program.
      Environmental factors such as handling, stress and thunderstorms did not effect
      efficiency except via a nutritional effect.

PMID- 1021112
TI  - A survey of dystocia in beef cattle in Southern Queensland.
AB  - Data relating to dystocia were obtained for 22% of beef herds in the Roma region
      of southern Queensland. In 1973 dystocia incidence in 23,129 maiden heifers was
      12%; 4% of heifers and 7% of calves died. Thirty-five per cent of the 444 herds
      surveyed had more than a 10% incidence of dystocia, and 10% had more than a 30%
      incidence of dystocia. Only 6% of herds had no dystocia. Among the 73% of
      producers considering dystocia a problem in most years, 14% regarded it as a
      major problem. The incidence of dystocia in heifers was significantly higher in
      Poll Hereford than Hereford herds, which in turn were higher than other breeds of
      cattle. Poll Hereford and Hereford owners were the most concerned about dystocia
      but did not supervise calving more frequently. Dystocia and attitude were also
      examined in relation to degree of supervision at calving and size of the breeding
      herd.

PMID- 1021113
TI  - An investigation into hindleg lameness in dairy cows.
AB  - A hind leg lameness of dairy cows was investigated in south-east Queensland.
      Samples of bone, blood, saliva, faeces, urine and milk were collected from lame
      and normal cows, some of which had received a phosphorus supplement of 30 g per
      day. Results of these investigations are presented and discussed. Clinical
      observations and pathological examinations indicated that the disease was an
      arthropathy affecting either the coxo-femoral or femoro-tibial joints. The
      disease was present in 30% of herds surveyed. Each owner reported 2 to 3 lame
      cows. The affected cows could not be differentiated from the normal cows on
      biochemical grounds. An hypothesis is advanced to explain the reported response
      of lame animals to large supplements of phosphorus. Information which indicates
      that previous nutritional status and methods of production cannot be ignored as
      predisposing factors is presented.

PMID- 1021114
TI  - Field trials with lyophilised herpesvirus of turkeys vaccine against Marek's
      disease in layer and broiler rearing flocks.
AB  - The safety and immunogenicity of commercial lyophilised herpesvirus of turkeys
      (HVT) vaccine against Marek's disease (MD) was evaluated in 19 field trials
      involving 76,848 vaccinated and 87,590 control chickens. In the first series of
      11 trials involving one commercial vaccine at a dose of 536 plaque forming units
      (PFU) there was a significant reduction in the incidence of MD (P less than
      0.001) and in total mortality (P less than 0.001) from 0 to 18 weeks due to
      vaccination and the overall protection was 85.2%. In the second series of eight
      trials involving another commercial vaccine at a dose range of 1360 to 1900 PFU
      there was a significant reduction in the incidence of MD (P less than 0.001) from
      0 to 18 weeks of age due to vaccination. The overall protection was 77.8%. In
      both series there was a significant difference in MD mortality between meat
      breeders and crossbred pullets (P less than 0.005) in response to vaccination.
      There was also a significant difference in total mortality from 0-6 weeks of age
      between the two series suggesting either differences in response to the two
      vaccines or differences in the vaccination technique. In a number of trials the
      incidence of MD was low in the controls, however, where MD incidence was above 2%
      in the controls protection usually exceeded 80%. It was concluded the vaccines
      were safe and efficacious and the degree of protection was comparable to that
      obtained by HVT vaccines described in other countries.

PMID- 1021115
TI  - The influence of severe weight loss in cattle on plasma constituents used in
      diagnosis.

PMID- 1021116
TI  - Supply and demand for veterinarians and the future in Australia.

PMID- 1021117
TI  - The isolation of D'Aguilar virus from a cow.

PMID- 1021118
TI  - "Computed cranial tomography in the investigation of acoustic neurilemmomas.".

PMID- 1021119
TI  - Kerosene pneumonia--its incidence in Perth and case history of a recent fatality.

PMID- 1021120
TI  - Radioisotope perfusion and ventilation studies in bronchial hilar neoplasia.

PMID- 1021121
TI  - Colonic juvenile polyps in a family.

PMID- 1021122
TI  - P.T.C.--Luck--8/3 pir3.

PMID- 1021123
TI  - Ultrasound and the missing loop.

PMID- 1021124
TI  - Pelvi-ureteric obstruction in children.

PMID- 1021125
TI  - 3 case reports of posterior urethral valves with varied presentations.

PMID- 1021126
TI  - Angiographic findings in diaphragmatic rupture.

PMID- 1021127
TI  - Spondylo-metaphyseal dysplasias (report of a case of common type and three pairs
      of siblings of new varieties).

PMID- 1021128
TI  - Achondrogenesis: a clinical and radiological report.

PMID- 1021129
TI  - A case of spinal arteriovenous malformation. The value of selective spinal
      angiography in its management.

PMID- 1021130
TI  - Weismann-Netter syndrome (toxopachyosteose diaphysaire tibio-peroniere).

PMID- 1021131
TI  - Doses received in finger-tips by persons working in a nuclear medicine centre.

PMID- 1021132
TI  - The study of dose distribution in radiotherapy using three types of
      thermoluminescent dosimeters.

PMID- 1021133
TI  - Computer-based auditing in a radiological department.

PMID- 1021134
TI  - The saving of silver.

PMID- 1021135
TI  - Variation of exposure rate with field size.

PMID- 1021136
TI  - Dosimetric considerations for the proposed usage of 125I sodium iodide in
      thyrotoxic patients presenting with and without hot autonomous nodule/s.

PMID- 1021137
TI  - Some aspects of reproduction in fat-tailed sheep in the subtropics V. Seasonal
      variation in sexual desire and semen characteristics.
AB  - The seasonal variations in sexual desire and semen characteristics were studied
      in five 1.5 to 2.5 years young and five mature (4 to 5 years old) fat-tailed
      Ausimi rams. The sexual desire was assessed according to the "reaction time"
      (period between initiation of the ram and the semen delivery into the artificial
      vagina): the sperm quality was assessed with the usual parameters. Although the
      breeding ability of the rams was continuous throughout the year, the sperm
      density was highest in the summer (due to long daylight periods). On the other
      hand the sexual desire and semen volumen reached their peak during the autumn.
      This and other results denote that the complex environmental factors controlling
      sexual activity exhibit different seasonal effects on different parts of the male
      reproductive system.

PMID- 1021138
TI  - Productive and reproductive adaptations of Friesian cattle introduced to a
      suptropical environment.
AB  - Various parameters were studied in imported and in local female cattle under the
      conditions in Iraq. The following results were obtained: The age at the first
      calving was lower in the animals imported in 1964 and 1965 than in the locally
      born cows. The age at the first calving in the daughter cows of the imported
      animals increased significantly by 1.6 months per year. The calving interval and
      the duration of the post-partum periods were longer in imported dams than in
      daughter cows. The gestation period was shorter in the imported dams than in the
      daughter cows. The lactation length and the dry period were longer in the
      imported dams than in their locally born daughters. The percentage of calves born
      during the life of all recorded cows in the studied herd was higher in the
      imported dams.

PMID- 1021139
TI  - [The curative action of Monticelli Term's water in upper respiratory tract
      diseases (author's transl)].
AB  - The Authors study the action of the sodio bromide-iodic water of Monticelli Terme
      in upper respiratory tract disease and particularly assert that is not to neglect
      the organic ground on which establishes mucosa's disease. Therman treatment gives
      the best therapeutic results in every patient presenting chronic inflammatory
      processes of the upper respiratory trach alternating periods of quiescency and of
      activity, and poor therapeutic action in patients presenting chronic inveterate
      diseases with great alterations in vascular and glandular components of the
      mucosa.

PMID- 1021140
TI  - [Correlation between histological findings and clinical behavior following
      surgery for portal hypertension in cirrhosis (author's transl)].
AB  - This is a retrospective study of 29 cirrhotic patients who underwent surgery for
      haemorrhage or ascites due to portal hypertension, carried out to look for any
      correlation between histological findings and clinical outcome. When Mallory's
      bodies and signs of activation are found, indicating that the cirrhosis is
      progressing, the clinical results are often discouraging. A careful choice of
      which cirrhosis patients are likely to gain from surgery should take account of
      selective histological criteria as well as full clinical and haemodynamic data.

PMID- 1021141
TI  - [Research on the quality of the Po River and its tributaries in the region of
      Cremona-Casalmaggiore mountain. III. 1972-1973].
AB  - The analises of water samples collected during the second research period, year
      1972-73, in the tract of the river Po from Cremona to Casalmaggiore partly
      confirmed the results obtained in the first period (1971-72). However we have to
      consider that during this second research year the hydrological conditions of the
      river Po have been very similar to the average ones of the last 30-40 years. The
      fact is particularly important and it permitted us to better value all those
      parameters which feel the effects of the flow variations. Also in this second
      period the different parameters didn't present significative variations upstream
      and downstream Cremona and at Casalmaggiore except the turbid load as happened in
      1971-72 period. As far as the water qualities are concerned no significative
      differences have been registered between the two paeriods; in fact the most part
      of the physioco-chemical parameters keep suitable levels for fish life and
      drinking purposes; meanwhile, except some particular situations, the
      microbiological indexes exceed the limits for bathing waters fixed by the W.Q.C.
      and by the Italian Ministry of Health.

PMID- 1021142
TI  - [Studies on the quality of water of the right side tributaries of the Po River;
      Trebbia and Nure, in 1971-1973].
AB  - In the period 1971-73 samplings were taken out monthly at the mouths of the two
      right side tributaries of the river Po, Trebbia and Nure. The aim of the research
      was to value the water quality, the polluted load conveyed to the river Po and to
      compare the real load with the one estimated on the basis of inhabitants and the
      basin area. Both the water courses are torrent-like rivers with highflow values
      in the winter and low flow values in the summer (July and August). There are no
      important industries in the basins studied and the high polluted effluents,
      mainly domestic and agricultural discharges, are placed in the plain tracts of
      the rivers at few kilometers from the mouths. As far as the water quality of both
      rivers is concerned, most of the chemical parameters maintain suitable levels for
      fish life and drinking purposes; on the contrary the microniological indexes
      exceed the limits for bathing fixed by the Italian Ministry of Health by 100
      E.coli 100/ml. and by 1000 total coliforms 100/ml. in about 90 and 70-80% of
      samplings. The comparison between real and calculated loads has shown a good
      agreement for BOD and chloride in Trebbia and for BOD and phosphates in Nure.

PMID- 1021143
TI  - [Simultaneous evaluation total and selective of GFR and ERPF with Hypaque-131I
      and with Hippuran-125I (author's transl)].
AB  - The Authors report their experience regarding the use of radioisotopes (Hypasults
      obtained in 40 healthy subjects confirm the reliability of the separate tests.
      Limitation and value of plasmatic and urinary clearances are briefly discussed.
      As the methods are simple, reproducible and unharmful for the patient, the
      Authors suggest an increasing application of these radioisotopic techniques for
      clinical purposes.

PMID- 1021144
TI  - [The preparation and characterization of steroid antisera (author's transl)].
AB  - The steroids, as compounds of low molecular weight, are not immunogenic; however,
      certain small molecules (haptens) when covalently linked to proteins become
      antigenic i.e., they provoke the production of unique antibody. If a steroid were
      covalently copuled to a protein, an artifical antigen would be produced capable
      of eliciting the formation of antibody with specificity not only for the protein
      carrier but also for the particular haptenic steroid. The results would be an in
      vivo production of a tailor made binding sites for any steroid that can be
      attached as a hapten to a protein by covalent bonds and thus become antigenic.
      This procedure allow the preparation of steroid specific antisera suitable for
      clinical use in radioimmunoassay, methods. The Authors report the techniques of
      preparation of steroid-derivative antigens of Androstenedion, Testosteron, and
      Progesteron. The three derivative steroid antigens have shown a good antigenic
      property by eliciting the formation of specifical antisera in 5 out of 6 rabbits
      used for the immunization. After 10 weeks from the beginning of immunization
      antisera useful in radioimmunoassay at the diluition 1/300; 1/1600; 1/2000
      respectively for Progesteron, Testosteron and Androstenedion were obtained. The
      standard curves show a good sensitivity suitable for clinical use.

PMID- 1021145
TI  - [Traumatic rupture of the diaphragm (twelve cases) (author's transl)].
AB  - Twelve cases of male patients with traumatic rupture of the diaphragm are
      reported. Eleven involved the left hemidiaphragm, and the twelfth the right. The
      aetiopathogenetic and anatomical-pathological aspects are discussed, and stress
      is laid on the importance of early diagnosis. In general, the most effective form
      of reanimation is prompt surgery, reducing the herniated organs in the abdominal
      cavity, re-expanding the lungs, and treating the frequent concomitant visceral
      lesions as each case demands. The criteria followed in selecting the route of
      access to traumatic lesions of the diaphragm are described; in most of the cases
      reported, the thoracic route was preferred, often associated with laparotomy.

PMID- 1021146
TI  - [Prevention and treatment of infections in open heart surgery (author's transl)].
AB  - The incidence of bacterial infections in 207 patients who underwent
      cardiopulmonary bypass surgery is reported. The effectiveness of various
      prophylactic antibiotic therapies is debated on the basis of performed
      antibiograms and the results are compared with that obtained by other Authors
      using different treatments.

PMID- 1021147
TI  - [The not choreic neurological complications of rheumatic disease (author's
      transl)].
AB  - The authors discuss the importance of neurological complications of rheumatic
      disease, which differ from those of Sydenham's chorea: encephalitis; acute
      cerebral circulatory insufficiency of cardiovascular basis; thrombosis and
      cerebral haemorrhage; cerebral emboli; and vasculitis. The case of a 13 year old
      boy who presented with an acute cerebral episode during an active phase of
      rheumatic fever is described. The E.E.G. showed a right hemisphere disturbance
      with a slight involvement of the controlateral hemisphere. The cardiac evidence
      was indicative of a rheumatic carditis. The clinical progress and EEG were
      rapidly favourable. The possible pathogenetic hypotheses of this case are taken
      into consideration, and the authors suggest that one must suspect a rheumatic
      etiology when an acute cerebral syndrome is established in a child or a young
      adult with current or previous rheumatic fever.

PMID- 1021148
TI  - [Erythrocytes' deformations in primitive muscular dystrophies (author's transl)].
AB  - On the light of previous reports on a possible correlation between
      echinocytogenesis and primitive muscular dystrophies, we have investigated the
      presence and time dependent development of echinocytes in the blood of normal
      subjects, patients and healthy carriers of D.M.D. A very few echinocytes are
      present in the fresh blood of all the patients and some carriers, but not in the
      blood of control normal subjects. With time, more echinocytes develop in all
      cases but much more markedly for sick people and carriers. These results might
      explain conflicting data on the echinocyte content in the blood reported in the
      literatura and provide a guideline for a correct analysis of the phenomenon and
      its possible relevance in the eugenetic diagnosis of carriers.

PMID- 1021149
TI  - [On fatal case acute ethyl alcohol poisoning (author's transl)].
AB  - A fatal case was reported of acute intoxication with ethyl alcohol, in which the
      alcohol levels were higher than any previously reported by Italian workers. On
      the basis of the normal blood alcohol curve patterns, in the case in question the
      absorption phase must have lasted longer than the hours usually considered as
      maximum for absorption of ethyl alcohol.

PMID- 1021150
TI  - [Possibilities of drug treatment in some sex behavior anomalies].
AB  - In this article the authors reconsider the literature about the drug treatment of
      sexual behaviour anomalies. In fact, the therapy of subjects convicted for sexual
      offences has been widely studied. The various drugs at disposal may be divided
      into three main groups: 1) oestrogens; 2) progesterone derivatives; 3) psycho
      tropic-drugs. Among oestrogens the most widely used are oral stiboestrol and
      oestron. Recently, oestradio has been implanted subcutaneously. Even if effective
      all of them present some inconvenients, sometimes serious one, such as breast
      cancer. Recently drugs of the second group have been used. The most important of
      them is Cyproterone acetate, a synthetic substance, which is classified as
      antiandrogen and whose structure is like to progesterone. The effects in
      achieving a complete loss of libido and of sexual power have been judged
      satisfactory by all the authors who have experienced this drug. In U.S.A., where
      use of Cyproterone is still interdected, Medroxyprogersterone acetate is used
      parenterally and by depot with similar therapeutical effects. To the last group
      belong various drugs. The most used in benperidol, a neuroleptic, classified by
      many authors as antiandrogen.

PMID- 1021151
TI  - [Clinical control, study of viral shedding and evaluation of circulating and
      local antibody response after administration of live and attenuated "Alice"
      strain influenza vaccine].
AB  - Thirty-four young adults were inoculated intranasally by nose drops with two
      doses, two weeks apart, of inhibitor resistant "Alice" vaccine strain of
      A/England/42/72 (H3N2). By the rate of volunteers with clinical reactions, always
      mild and short-lasting, the vaccine showed a low degree of reactogenicity. Viral
      shedding was evidenced only the day after the first dose and was limited to two
      vaccinees. Two weeks after the first dose homologous serum h.i.a. appeared in all
      the 15 volunteers lacking prevaccination antibody and significant titer rises
      occurred in a substantial number of vaccine recipients with low titers. The
      incidence of subjects with h.i.a at titers considered to be protective (larger
      than or equal to 1:40), which was 26% before vaccination, rose to 93% in fully
      vaccinated volunteers. Very likely because of the presence of n.i.a. in the
      prevaccinal serum of all the volunteers, the n.i.a. response was less
      satisfactory. The vaccine induced h.i.a. to A/Port Chalmers/73 e A Scotland/74
      (H3N2) variants, although in a lower titer than to the homologous strain. Serum
      h.i. and n.i. antibody response appeared not to be significantly increased by a
      second dose. H.i.a., never present in the first sample, were found in the nasal
      washings taken two weeks after the second dose from 9 out of 16 vaccinees
      examined. Antibody was detected more frequently in the specimens with relatively
      high levels of protein and IgA. Secretory n.i.a., already demonstrable in 7
      volunteers before vaccination, were acquired by all but one at the end of the
      experience.

PMID- 1021152
TI  - [Homologous and heterologous antibody response induced in man by anti-influenza
      vaccine containing A/England/42/72 and b/Massachusetts/71].
AB  - In november 1973, 43 subjects living in a home for aged were given one dose of
      influenza vaccine, containing A/England/42/72 and B/Massachusetts/71. After 4 and
      20 weeks, sera were tested for antibody contentto the homologous and to A/port
      Chalmers/1/73 viruses by haemoagglutination inhibition technique. Control group
      included 23 untreated subjects. The satisfactory increase in the anti
      A/England/42/72 antibodies induced by vaccine indicated a good antigenic potency
      of the A component. The satisfactory cross-reacting response suggests that the
      "drift" in antigenic content between A England/42/72 and A/Port Chalmers/1/73 was
      moderate. On the contrary the increase in anti-B/Massachusetts/71 antibodies
      after vaccination was observed only in a limited number of cases. Twelve subjects
      (9 treated and 3 controls) experienced upper respiratory tract infections which
      appeared to be not related to infuenza viruses.

PMID- 1021153
TI  - [Distribution of serum Australia antigen (HBs) in a group of Apulian blood donors
      according to sex and age].
AB  - 3183 sera from healthy adults, volunteer blood donors (18-65-year aged) have been
      tested by a commercial ria (ausria II Abbott), for detection of HBsAg. The
      frequency of Australia antigen wsa found to be 5.2% (168/3183) in all sera, 6.3%
      in male and 3.5% in female donors, with differences statistically significant (p
      less than 0.01). In male donors, the prevalence was highest in the first half of
      the life (18-40 years)(7.0%) than in the second half (41-65 years) (3.7%), and
      the difference was also statistiically significant (p less than 0.05). In female
      donors the HBs Ag frequency was 4.2% and 2.2% repectively for the first and the
      second half of the life, but the difference was not statistically significant.
      Possible epidemiological significances were discussed.

PMID- 1021154
TI  - Polymer structure and blood compatibility evaluation - application of an
      acrylonitrile copolymer.
AB  - An acrylonitrile-dimethylaminoethyl methacrylate copolymer has been synthesised
      by a straightforward procedure. The cationic nature of the copolymer permits
      ready attachement of heparin and reaction of the copolymer with ethylene oxide
      gas allows a controlled alteration in chemical structure. These featues of the
      copolymer are discussed with respect to the influence of polymer properties on
      blood compatibility as exemplified by blood platelet retention.

PMID- 1021155
TI  - Animal experiments with biogalvanic and biofuel cells.
AB  - Animal experiments with biogalvanic cells have demonstrated that an average power
      of 80 muW can be derived continously for at least 2 years. There is a further
      scope to stabilize the power at 100 muW for considerable longer periods so that
      the chances of cardiac pacing with biogalvanic power have become bright. However,
      large scale efforts are necessary in in establishing the statistical reliability
      and the secured performance which are expensive and time consuming. Animal
      experiments with biofuel cells are still in preliminary stages. We derived a
      continous power of 40 muW (4MUW/cm2) at 575 mV over 150 days so far. This is the
      longest recorded period with such a high power density. The main problem in
      deriving higher power over longer period is to properly encapsulate the cell with
      materials which are hydrophilic and essentially biocompatible.

PMID- 1021156
TI  - Lindholm blood coagulation test values of some glow-discharge polymer surfaces.
AB  - An ultrathin layer (approximately 500A) of glow-discharge polymer that is
      strongly bonded to a polymer film substrate can be sued to modify the blood
      compatibility of the polymer surface. Glow-discharge polymers of
      tetrafluoroethylene, hexamethyldisiloxane, ethylene-N2, and allene-N2-H20 were
      deposited onto Mylar film and subjected to Lindholm whole blood coagulation
      tests. Lindholm tests were performed in a manner that permitted statistical
      analysis. This was done by repeating the preparation of samples as well as the
      coagulation tests a number of times. Results showed that Lindholm tests values
      were useful in obtaining information pertinent to compatibility of surfaces with
      fresh human blood and to reproducibility of sample preparation by glow-discharge
      polymerization. The study also revealed that glow-discharge polymerization is a
      promising method to impart blood compatibility without altering other bulk
      properties of substrate polymers.

PMID- 1021157
TI  - Development of a pulsatile blood pump.
AB  - A new type of pulsatile roller pump is described. The pressure and flow
      characteristics and the wave forms generated by the pump together with the
      hemolysis measurements for different pumping parameters are presented and a
      comparison with a standard roller pump is made.

PMID- 1021158
TI  - Blood components deposited on used and reused dialysis membranes.
AB  - Hemodialysis cartridges used once and reused once or twice were examined by
      scanning and transmission electron microscopy. Blood deposits consisting of
      leukocytes, platelets, and amorphous material covered 15 to 25% of the dialysis
      membrane surface of cartridges used once. This deposit increased somewhat with
      cartridge reuse but did not appear to impair the dialysis efficiency of membranes
      significantly. Leukocytes formed a major part of the blood deposit and spreading
      of these cells upon dialysis membranes was marked. Single and aggregated
      platelets were adherent to the dialysis membranes, to leukocytes, and to
      amorphous debris. Few erythrocytes were present, and fibrin was not identified.
      There was little evidence for build up or layering of the blood deposit with
      cartridge reuse. The procedures for dialysis  cartridge rinsing used in these
      studies appear to be highly efficient in removal of adherent blood components.

PMID- 1021159
TI  - The rabbit ear chamber: a unique in vivo model for the continuous observation of
      implanted biomaterials.
AB  - The rabbit ear chamber provides a unique system for viewing an in vivo
      environment from outside the body. The plastic chamber, modified for our use, is
      described. Once surgically implanted into the ear of a Laboratory Lop rabbit, a
      thin tissue bed which grows between the layers of the chamber can be viewed
      through the microscope. The absorption of biomaterials placed into the chamber
      can then be observed as a dynamic process.

PMID- 1021160
TI  - Sub-total versus partial circulatory bypass of the left heart: a critical review.
AB  - A number of systems for left heart bypass have been described for short, or long
      term circulatory support in animals and in man. Critical to the interpretation of
      these restuls and to the design of new system is the proportion of left
      ventricular inflow destined for ejection which is diverted through the apparatus,
      to that expelled through the aortic valve, and the effect which this fraction
      might have on the failing heart and the rest of the body. It is the purpose of
      this communication to review the experimental and theoretical data in support of
      partial, as opposed to subtotal, left heart bypass.

PMID- 1021161
TI  - Non-polarographic blood gas analysis I. In virtro evaluation of gas chromatograph
      system.
AB  - A new system providing near continuous arterial p02 and pCO2 measurements without
      requiring blood samples is described. Based on intra-arterial placement of a
      closed-tipped 2F catheter with gas chromatographic separation and analysis this
      system appears capable of providing rapid sensitive data with accuracy and
      precision equivalent to conventional bench analyzers. The initial in vitro
      experiments are discussed including flow and temperature dependency studies.

PMID- 1021162
TI  - [Study of right-left asymmetry of the temporal planum in the fetus].
AB  - Study on the asymmetry of the planum temporale by means of brain sections of 17
      to 39 weeks old fetuses. There is a left predominance in 60 %, a right one in 25
      % and symmetry in 15 % of the cases. Our results are similar to those published
      about adult brain, and cerebral dominance depends on it. Cerebral lateralisation
      is congenital and not acquired. There is also direct relation between the length
      of the lateral border of the planum temporale and its area. Such measure could be
      undertaken in living persons by means of radiological examination.

PMID- 1021163
TI  - [Cinematic study of prosupination at the level of the radiocubital (radioulnar)
      articulations].
AB  - The authors, using cinematic methods have determined the positions of Instant
      Rotation Center (IRC) in upper and lower radio-ulnaris joints, in the movement of
      prosupination : -- At the upper radio ulnaris joint, the IRC divide themselves
      into 2 zones (I and II), corresponding to the centres of 2 circles of different
      diameters, each one respectively corresponding to large and small anatomical
      curves of the head of the radius. -- At the lower radio ulnaris joint, the IRC
      divide themselves into a third zone (III), situated opposite the head of ulna.
      The prosupination movement is effectuated around 2 axes delta I - II, and delta
      II - III : supination around delta I - III, and pronation around delta II - III
      in a first phase, ten around delta I - II in a second phase. The movement is not
      impaired if the ligamentum annulare radii is cut, but it is considerably impaired
      if the ligamentum quadratum is cut.

PMID- 1021164
TI  - [Urinary cytology in adult men].
AB  - Urinary cytology is a good test for estimation of woman's hormonal situation. In
      a previous paper, the authors showed an "estrogenic" like effect of digitalin, in
      urocytograms of post-menopausical women. In the present report, the urocytograms
      of 139 men, 17 to 84 years old, without any urinary disease and treated or not by
      digitalin, are studied. Normal urinary cytology in the adult and its
      modifications under digitalin treatment are shown.

PMID- 1021165
TI  - [Attempt at clarification of the topographic distribution of the different
      epithelial linings in the human trigono-urethral region].

PMID- 1021166
TI  - [Phylogenic interest of the clivo-pterygoid angle].
AB  - The comparison between the planum-clivus angle of Man and the african Pongids
      shows that the closing of this angle is the result of a noticeable rotation of
      the clivus and a less important rotation of the planum in an opposite direction.

PMID- 1021167
TI  - [Arterial vascularization of the patellar ligament (ligamentum patellase) and of
      the Achilles tendon (tendo calcaneous) in man].
AB  - Vascularization in ligamentum patellae and tendo calcaneus have been studied by
      microangiography with micropaque. Can be noted: 1. for the ligamentum patellae : 
      -its dense vascularization, --the existence of a vascularized sheath around the
      ligament, densely vascularized in the anterior part, --the important
      vascularization of the entire ligament in the foetus, but the less important
      vascularization at the middle third in the adult. 2. for the tendo calcaneus : --
      a relatively poor vascularization on the whole, -- a vascularized zone at the
      middle third, -- a periphereal vascularized sheath around the tendon, densely
      vascularized in the anterior part.

PMID- 1021168
TI  - [Arterial vascularization of the axis].
AB  - The authors have studied the vascularization in the axis by microangiography of
      bone sections from 5 foetuses and 8 adults. All the arteries originate from the
      vertebralis : periosteal vessels arising from anterior and posterior
      intertransversary arteries, supply arteries originating in ventral and dorsal
      arteries. There are 2 distinctive arterial arches, one on the anterior face of
      the first two cervical vertebrae, the other on the posterior half of the
      vertebral corpus of the dens. Vascularization in the dens has particularly been
      studied. There are no anastomoses between the arteries of the dens and those of
      the axis corpus in foetuses. On the contrary, there are such anastomoses in
      adults. The least vascularized zone seem to be the neck of the dens.

PMID- 1021169
TI  - [Arterial vascularization of the lumbar vertebrae].
AB  - The authors have studied the vascularization in the lumbar verebrae. All arteries
      originate in the arteriae lumbales. They form an internal supply plexus and a
      peripheral periosteal plexus. The internal supply plexus is formed by radicular
      arteries divided into an anterior branch (the abdominal artery), with its
      corporeal branches, and a posterior branch (the dorsal artery) forming the arcus
      posterior. The periosteal plexus is formed by an anterior plexus for the corpus
      vertebrae and a posterior plexus for the arcus posterior. Intra-osseous
      vascularization at the level of the corpus vertebrae has been described; showing
      a difference between foetuses and adults. In the foetus, the posterior supply
      vessels predominate, whereas in the adult, the anterior periosteal vessels
      predominate. At the arcus posterior there is no difference between foetuses and
      adults.

PMID- 1021170
TI  - [Cytogenetic studies in spontaneous abortions].
AB  - During the three last years, the authors carried out cytogenetic studies of
      couples with spontaneous abortions, and of spontaneously aborted foetuses. Among
      99 couples studied, 9 abnormal karyotypes were detected. In two cases, maternal
      balanced translocation appears obviously responsible. Concerning aborted foetuses
      on 46 karyotyped specimens, 13 are found to bear chromosome anomalies. The
      authors consider the value of cytogenetic studies when repeated spontaneous
      abortions occur.

PMID- 1021171
TI  - [A curious abnormality of the lesser omentum and the hepatic pedicle].
AB  - The author reports the case of a 3 month old foetus whose lesser omentum,
      normally formed, did not present any vascular or biliary element. Those elements
      formed together a pedicle at the back of the lesser omentum and entered into the
      liver at the rear of the caudate lobe. This anomaly probably results from
      bipartition of the initial mesogastre.

PMID- 1021172
TI  - [Nerve fibers and neuroglandular synapses in the pars intermedia of the pituitary
      gland in rats and guinea pigs].

PMID- 1021173
TI  - [Hemodynamic effects on embryonic endocardial morphology].
AB  - The modifications of endocardial cells on bulbar cushions of the chick embryonic
      heart have been studied using the SEM following an experimental stenosis of the
      pulmonary artery. This stenosis was produced by the occlusion of both 6th aortic
      arches on the 4th day of incubation by silver microclips. The formation of small
      craterlike defects was observed on the distal ventral and proximal left bulbar
      cushions. Giant intercellular openings appeared on the top of the proximal left
      bulbar cushion indicating some acceleration of the blood flow in this region.
      Phagocytes traversing the endocardium have been seen more frequently than in
      controls. It seems that the endocardium is relatively resistant to the described
      hemodynamic changes. These changes modify the passage of phagocytes into the
      blood stream as well as cell movements and exocytosis.

PMID- 1021174
TI  - [External morphology of the roe deet (Capreolus capreolus L)].
AB  - The results of a morphological study of the cerebellum of the roe-deer are given.
      The structural simplicity of Lobus Rostralis, the relatively small development of
      Lobulus Ansiformis fully agree with previous works on the pattern of the
      cerebellum in Ungalata.

PMID- 1021175
TI  - [Morphology of the communicating veins of the lower 3d of the leg].
AB  - The communicating veins of the lower third of the leg are topographically
      constant communicating veins but variable as to their morphology and number.
      Their course shows topographically two parts, namely a superficial or
      subcutaneous one and a deep or subaponeurotic one. In their subaponeurotical
      course, the communicating veins change their morphological aspect and sometimes
      become very complex. These communicating veins show valves, and venous blood is
      directed towards the depth. They also receive collateral branches emanating from
      adjacent muscles. Two kinds of communicating veins can be distinguished, a direct
      and a mixed one. The direct communicating veins predominate on the internal side
      of the leg. These connect the venous system of the great saphenous vein with the
      posterior tibial veins. On the external side, the mixed communicating veins
      predominate. They link the venous system of the short saphenous vein with the
      peroneal veins. Their function is also studied.

PMID- 1021176
TI  - A summary of the present status of CEA in diagnosis, prognosis and evaluation of
      therapy of colonic cancer.

PMID- 1021177
TI  - Clinical aspects of the CEA test.

PMID- 1021178
TI  - [Usefulness of CEA in the control of heteroplastic diseases after treatment].

PMID- 1021179
TI  - CEA assay in the follow-up of patients with extra-gastrointestinal malignancies.

PMID- 1021180
TI  - [Value of carcinoembryonic antigens in cancers of the cervix and uterus].

PMID- 1021181
TI  - [CEA and cancer of the cervix uteri].

PMID- 1021182
TI  - [Embryonic antigen in head and neck tumors].

PMID- 1021183
TI  - [Course of cea levels in the treatment of bronchial cancers by chemotherapy].

PMID- 1021184
TI  - [Value and limitations of CEA determinations in cancers of the esophagus and
      stomach].

PMID- 1021185
TI  - Significance of CEA determinations in patients with cancer of the colon-rectum
      and the mammary gland in comparison to physiological states in connection with
      pregnancy.

PMID- 1021186
TI  - [CEA and therapeutic strategy especially in breast cancers].

PMID- 1021187
TI  - [Value of carcinoembryonic antigen determinations in the evaluation and
      surveillance of breast cancers].

PMID- 1021188
TI  - [Problems of non-specificity--heterogeneity of CEA--inluence of exterior
      parameters. Introduction].

PMID- 1021189
TI  - A comparison of CEA-S and CEA concentrations in sera and the independence of CEA
      S, NCA and blood group antigens.

PMID- 1021190
TI  - [Comparative study of serum levels of NCA and CEA. Evaluation of clinical value].

PMID- 1021191
TI  - [Comparative study between CEA serum levels and leukocyte migration inhibition
      levels in bronchial cancers].

PMID- 1021192
TI  - [Carcinoembryonic antigen, alcohol and cirrhosis].

PMID- 1021193
TI  - [Study of the influence of tobacco usage on circulating CEA levels].

PMID- 1021194
TI  - [Radioimmunologic determination of CEA and NCA in serum of premature and term
      newborn infants].

PMID- 1021195
TI  - [Influence of various preparations of CEA as tracers on the quality of
      radioimmunologic determinations].

PMID- 1021196
TI  - New developments in the domain of prognosis and diagnosis. Introduction.

PMID- 1021197
TI  - The influence of CEA-S from different tumors and of CEA as 125I ligands on the
      specificity of the CEA-S radioimmunoassay.

PMID- 1021198
TI  - [Study of CEA determination in untreated bronchial cancers. Relation between
      serum levels and spread].

PMID- 1021199
TI  - [Influence of manufacturing and storage conditions on the bioavailability of
      pharmaceuticals].

PMID- 1021200
TI  - [Postural changes secondary to caloric stimulation of the labyrinth: reflexologic
      analysis in man].

PMID- 1021202
TI  - [Cerebral tomodensitometry (EMI scanner)].

PMID- 1021201
TI  - [Cardiovascular adaptations induced by vertical immersion].

PMID- 1021203
TI  - [Selective deep hypothermia for peroperative protection from myocardial
      ischemia].

PMID- 1021204
TI  - Exorcism, possession, and the Dracula cult: a synopsis of object-relations
      psychology.

PMID- 1021205
TI  - Symptom substitution.

PMID- 1021206
TI  - Clinical relevance of the boundary functions of language.

PMID- 1021207
TI  - Preconscious awareness of impending death: an addendum.

PMID- 1021208
TI  - The anatomy of dependence. By Takeo Doi, M.D.: a discussion.

PMID- 1021209
TI  - Naming: a measure of relationships in a ward milieu.

PMID- 1021210
TI  - Electrophysiology of neural units in goldfish optic tectum.
AB  - Axons of retinal ganglion cells showed responses not previously emphasized: (a)
      many tonic units discharged oscillations, 2--12 spikes per burst, interburst
      intervals 20--300 msec; (b) phasic units showed concentric or flanking ON and OFF
      fields, response frequency depended on balance of retinal excitation and
      inhibition; (c) directional sensitivity was maximal for retinal stimuli moving in
      naso-temporal direction; (d) in anterior tectum deep afferent layer (DAL)
      provides for deep electrical sink, fibers of DAL have small fields, mostly in
      front of fish; (e) color-opponent units are prevalent in the superficial terminal
      layers, color is spatially and temporally represented. Tectal cell responses were
      distinguished by large visual fields, spontaneity, multiple spikes and long
      latencies to optic nerve stimulation, failure to follow above 60 per sec,
      plasticity of response. Tectal neurons of three classes included (a) cells of one
      type in upper layers were inhibited in ongoing activity by visual input,
      receptive fields exceeded 100 degrees, were often oblong, responses did not
      habituate; (b) cells of second type were excited by visual stimuli, became
      unresponsive (habituated) or responsive only to stimuli in different position or
      direction (newness cells); lability precluded field mapping and dishabituation
      was produced by change in background, extraneous stimulation, and spontaneous
      firing; (c) pyriform cells in periventricular layer were abundant, difficult to
      isolate electrically, discharged spontaneously in bursts at intervals of several
      seconds and responded to visual input by interruption of firing. Some tectal
      cells responded to non-visual stimuli as well.

PMID- 1021211
TI  - Thermoregulatory cold-defense deficits in rats with preoptic/anterior
      hypothalamic lesions.
AB  - This paper discusses the course of recovery from the thermoregulatory deficits
      produced in rats by electrolytic lesions in the preoptic/anterior hypothalamic
      area. Severe damage rendered rats ectothermic, that is unable to maintain their
      body temperatures at normal levels unless they were incubated at an ambient
      temperature of 30 degrees C. Less severe damage produced rats that maintained
      subnormal but stable body temperatures at 23 degrees C, but that did not increase
      metabolic rate or shiver and whose body temperatures dropped drastically in the
      cold (5 degrees C). As the animals recovered, nonshivering thermogenesis
      returned. Eventually the rats became excessively hyperthermic in normal room
      temperatures, due to very high metabolic rates. They were still unable to shiver
      or increase metabolic rate further in the cold and were therefore still unable to
      prevent a large drop in body temperature. Muscle tonus and shivering recovered
      gradually, and oxygen consumption returned to near normal levels. The data are
      described in terms of levels of integration of the nervous control of
      thermoregulation.

PMID- 1021212
TI  - Melanin in the rat brain.
AB  - Melanin was measured in various parts of the rat brain by a
      spectrophotofluorometric assay. This method could detect natural, Sepia melanin
      as well as melanin synthesized from L-DOPA. Contrary to published expectations of
      other investigators, measurable amounts of melanin were found in the brain of
      albino as well as pigmented rats. The highest concentrations of melanin occurred
      in the pons-medulla and midbrain, but all regions within the blood-brain barrier
      contained greater concentrations than samples from many other tissues in the
      body. No significant change in the melanin content was found after various
      endocrine manipulations such as removal of the pituitary, pineal, adrenals,
      thyroid, testes, or ovaries, exposure to constant illumination or darkness, and
      daily injection for 5 weeks of alpha-MSH, Pro-Leu-Gly-NH2 (MIF-I) or melatonin.
      As expected, retinal tissue from black-hooded rats contained extremely high
      levels of melanin whereas that from albino rats contained no melanin. It is
      thought that the presence of melanin in the brain of albino and pigmented rats
      may have a function which is still unknown.

PMID- 1021213
TI  - Neuromuscular blockade: the effects on two hippocampal RSA (theta) systems and
      neocortical desynchronization.
AB  - Neocortical and hippocampal electroencephalographic (EEG) activity were recorded
      from rats during: (a) spontaneous activities, (b) paralysis produced by curare or
      gallamine neuromuscular blockade, and (c) urethane anesthesia. All of the
      patterns of EEG recorded from normal rats were obtained from paralyzed rats
      including: (a) atropine resistant neocortical desynchronization and fast (6--12
      Hz) hippocampal rhythmical slow activity (RSA) normally associated with overt
      Type I or voluntary movement, (b) atropine sensitive and urethane resistant slow
      (4--6 Hz) RSA which can be recorded from immobile animals during conditioning
      procedures, or during brain or sensory stimulation, and (c) large amplitude
      irregular neocortical and hippocampal EEG which can be recorded from immobile or
      sleeping animals. Depth profiles of RSA were taken from the hippocampal formation
      of urethanized and curarized rats during posterior hypthalamic stimulation. The
      results confirmed findngs of two RSA amplitude maxima with an approximate 180
      degree phase difference, one location in stratum oriens of area CA-1, the other
      in stratum moleculare of the dentate gyrus, and suggest there are two generators
      of RSA. Atropine sensitive and atropine resistant types of RSA were found in each
      generator. The results suggest that RSA may be supported by both cholinergic and
      noncholinergic input to each generator and that neither RSA type could be only
      the result of proprioceptive feedback from joints or muscles.

PMID- 1021214
TI  - Cerebellar nuclear stimulation in generalized penicillin epilepsy.
AB  - Comparison was made of the effectiveness of cerebellar cortical and nuclear
      stimulation in reducing paroxysmal activity induced in cats by parenteral
      penicillin administration. Vermal cortical and fastigial nuclear stimulation at
      high frequencies (100 Hz) were both effective in reducing the number and duration
      of paroxysmal events while the effects of dentate nucleus stimulation were found
      to be more variable. It was suggested that effective seizure inhibition appeared
      to be associated with increased fastigial output and resultant reticular
      excitation.

PMID- 1021215
TI  - Visual performance and synapses in the visual cortex of rabbits.
AB  - The density of synaptic connections, the length of the contact zones and the
      number of synaptic vesicles are quantitatively studied in the left and right
      hemisphere of a group of rabbits a number of which showed marked ocular
      dominance. No systematic differences in the parameters studied could be observed
      in the visual cortex between symmetric animals, indicating that the ocular
      dominance cannot be explained by hemispheric differences in density of synapses.

PMID- 1021216
TI  - Effect of adrenaline on insulin secretion in rats treated chronically with
      adrenaline.
AB  - To determine whether rats could adapt to a chronic exogenous supply of adrenaline
      by a decrease in the well-known inhibitory effect of adrenaline on insulin
      secretion, plasma glucose and insulin levels were measured in unanesthetized
      control and adrenaline-treated rats (300 mug/kg twice a day for 28 days) during
      an adrenaline infusion (0.75 mug kg-1 min-1), after an acute glucose load (0.5
      g/kg), and during the simultaneous administration of both agents. Chronic
      treatment with adrenaline did not modify the initial glucose levels but it
      greatly diminished the basal insulin values (21.57+/-2.48 vs. 44.69+/-3.3muU/ml,
      p less than 0.01). In the control rats, despite the elevated glucose
      concentrations, a significant drop in plasma insulin levels was observed within
      the first 15 min of adrenaline infusion, followed by a period of recovery. In the
      adrenaline-treated group, in which plasma glucose levels were lower than in
      control animals, plasma insulin levels did not drop as in control rats, but a
      significant increase was found after 30 min of infusion. During the intravenous
      glucose tolerance test, the plasma glucose and insulin responses showed similar
      patterns; however, during the concomitant adrenaline infusion, the treated rats
      showed a better glucose tolerance than their controls. These results indicate
      that rats chronically treated with adrenaline adapt to the diabetogenic effect of
      an infusion of adrenaline by have a lower inhibition of insulin release, although
      the lower basal insulin levels may indicate a greater sensitivity to endogenous
      insulin.

PMID- 1021217
TI  - Arterial bifurcation flows--effects of flow rate and area ratio.
AB  - Velocity profiles and surface shear rates, for three model symmetrical
      bifurcations made of glass from dimensions based on the arterial system, were
      investigated. The models studied had area ratios of 0.75, 1.02, and 1.29, with a
      common included angle of 75 degrees. Area ratio and parent tube flow rate were
      the two independent variables evaluated. Measurements were made with a tracer
      particle technique using cinephotography. Velocity profiles had their highest
      values on the inside, and lowest values on the outside, of the branch. Flow
      symmetry existed in the plane perpendicular to the plane of the bifurcation.
      Surface shear rates remained well above the daughter-tube developed values,
      between two and six diameters downstream from the carina. Shear rates below the
      daughter-tube developed value were found on the outside wall between the carina
      and two daughter-tube diameters downstream. Vortex-like flow was absent in this
      region for the 0.75 area ratio branch and was found above 900 Reynolds number in
      the 1.29 area ratio branch. The disturbed flow described by others in this region
      may not contain vortex-like streamlines for the physiologically important 0.75
      area ratio.

PMID- 1021218
TI  - Light and dark smooth muscle cells in estrogen-stimulated rat myometrium.
AB  - Smooth muscle cells of different densities to transmission of electrons (termed
      light and dark cells) were found in rat myometrium examined in the electron
      microscope following fixation by immersion in glutaraldehyde. Light cells
      accounted for about 4% of the total population of cells. No light cells were
      found in tissues fixed in situ by intraarterial perfusion with glutaraldehyde. In
      addition to staining differences, light cells were distinguished from most dark
      cells by differences in nuclear, mitochondrial, endoplasmic reticular, and
      surface structures. The relative number of light and dark cells after in vitro
      fixation was not changed in tissues relaxed with adrenaline or contracted with
      oxytocin. Mechanical injury resulted in increased numbers of light cells.
      Similarly, chemical injury with metabolic inhibitors resulted in ATP depletion,
      followed by increased numbers of light cells and gain in water content. We
      concluded that light cells were produced by mechanical or metabolic damage,
      leading to loss of volume control mechanisms, swelling, and leakage of protein.
      Light cells found after fixation in vitro in numerous prior studies represent
      cells damaged during isolation, and not a physiological variant among smooth
      muscle cells.

PMID- 1021219
TI  - Binding of anticonvulsant drugs to cytochrome P-450: correlation with evidence of
      induction of hepatic microsomal enzymes.
AB  - Mephenytoin, diphenylhydantoin, pheneturide, and phenobarbital produced a
      concentration-dependent inhibition in the binding of hexobarbital to cytochrome P
      450 at the type 1 site, while sulthiame slightly potentiated, and ethosuximide
      did not affect the binding characteristic of hexobarbital. Diphenylhydantoin,
      phenobarbital, and pheneturide have previously been shown to enhance the urinary
      excretion of D-glucaric acid (DGA), while sulthiame inhibited the potentiation of
      DGA excretion caused by these drugs, and ethosuximide produced no change. The
      results suggest a close relationship between the ability of these drugs to induce
      hepatic microsomal drug-metabolizing enzyme systems (as indicated by enhancement
      of DGA excretion) and binding behaviour at the type 1 site.

PMID- 1021220
TI  - The necessity of drug level monitoring in anticonvulsant drug therapy.
AB  - A survey of 'steady-state' serum levels of anticonvulsant drugs from 221
      epileptic patients at a university hospital was conducted. Serum concentrations
      of phenobarbital, primidone, and diphenylhydantoin were determined by a gas
      chromatographic method. Sixty-five percent (130) of the patients receiving
      diphenylhydantoin had levels below the therapeutic range of 10-20mug/ml.
      Subtherapeutic levels appear to be due to inadequate dosage adjustment. Only 25%
      (33) of the patients receiving phenobarbital had levels below the therapeutic
      range. Serum levels of diphenylhydantoin or phenobarbital could not be predicted
      from dosage. Most patients received two or more drugs. Over 10% of the patients
      had potentially toxic levels of anticonvulsant drugs. High levels of
      diphenylhydantoin were easily recognized clinically but high levels of
      phenobarbital were not.

PMID- 1021221
TI  - Effect of alterations in ambient temperature on blood flow in the skin.
AB  - The effect of changing ambient temperature on skin temperature was recorded in
      human subjects; also, its effect on blood flow was measured using venous
      occlusion and optical plethysmography. When cold stimulus was removed in stages
      using a heating cabinet, it was found that a biphasic flow response occurred in
      the fingers with each step change in temperature. There was a rapid transient
      rise followed by a decline to an equilibrium flow level. The transient rise
      occurred even when the temperature rose from 37 to 40 degrees C, although at this
      level the equilibrium remained unchanged. It is suggested that the transient rise
      was due to stimulation of Hensel's dynamic warmth receptors, whereas the rise in
      equilibrium temperature was due to removal of cold stimulus, which at low ambient
      temperatures maintains reflex vasoconstriction through activation of static cold
      receptors. Upper arm skin responded to removal of cold stimulus by a fall in
      temperature. Immersion of a different limb in cold water produced
      vasoconstriction in fingers but vasodilatation in the upper arm skin. It is
      suggested that this may be due to neurogenic vasodilatation, though the present
      work gives no indication as to pathways.

PMID- 1021222
TI  - Survial of fasted rats exposed to altitude.
AB  - Rats fasted for 48-96h before exposure were shown to have a longer survival time
      at groups 33,500 ft (1 ft = 0.305 m) simulated altitude than nonfasted controls.
      Although both become hypothermic at 33500 ft, colonic temperatures of the fasted
      rats were not sufficiently lower than those of nonfasted animals to explain the
      difference in survival time. The injection of glucose and insulin before exposure
      almost completely eliminated the protection afforded by fasting, whereas glucose
      alone had no effect on survival. It is therefore suggested that an alteration in
      carbohydrate metabolism, possibly in combination with other starvation-induced
      changes, allowed fasted rats to survive at 33500 ft until declining body
      temperature reduced metabolic rate to a level compatible with oxygen supply.

PMID- 1021223
TI  - Vasopressin contamination as a cause of some apparent renal actions of prolactin.
AB  - The injection or infusion of NIAMDD prolactin (NIH P-S-10) into unanesthetized
      rats resulted in water and electrolyte retention with a large increase in urine
      osmolality but no effect on glomerular filtration rate. Since these effects on
      urine output were also observed in homozygous Brattleboro rats, the antidiuretic
      activity could not have caused by the release of endogenous antidiuretic hormone.
      Radioimmunoassay of NIH prolactin showed that it was contaminated with
      vasopressin (20 ng/mg of prolactin). By comparison, Sigma prolactin had no
      observed effect on urine excretion and contained very little vasopressin (2.5
      ng/mg). It is concluded that some of the renal effects of prolactin have been
      reported in the literature may have been caused by the contaminating vasopressin.

PMID- 1021224
TI  - Release of [3H]noradrenaline from perfused rat hearts by potassium and its
      modifications by 6-hydroxydopamine and reserpine.
AB  - The sources of noradrenaline (NA) released by excess potassium from isolated
      perfused rat hearts were investigated by labelling the hearts from normal,
      reserpine-treated, and 6-hydroxydopamine-treated (6-OHDA-treated) rats with
      [3H]HA, and measuring the increased rate of efflux induced by perfusion with a
      Krebs solution containing varying amounts of excess potassium. The [3H]NA and its
      metabolites in the effluent were separated by adsorption on alumina and a cation
      exchange resin (Dowex-50). The release induced by potassium was a linear function
      of the log of the increased potassium concentration. Following a 1-h efflux
      period after labelling with [3H]NA, the hearts from reserpine-treated rats
      retained 1/5 as much [3H]NA, and released, in response to a 56mM elevation in the
      potassium concentration, less than 1/6 as much tritium label as the hearts from
      untreated (control) animals. In contrast, the hearts form 6-OHDA-treated animals
      retained 1/15 of the amount of [3H]NA and released 1/50 of the 3H label as did
      the control hearts. The potassium-induced increase of 3H-labelled substances in
      the effluent from the control hearts showed a large (threefold) percentage
      increase in the [3H]NA fraction, whereas the effluents from the hearts of
      reserpine- and 6-OHDA-treated animals contained only small increases in the
      [3H]NA fraction. Based on the assumptions that reserpine prevented retention of
      NA in the storage granules whereas 6-OHDA prevented almost all neuronal storage,
      it was concluded that more than 80% of the NA released by potassium excess from
      perfused normal hearts originated from the storage vesicles of the nerves, the
      remainder being largely from the cytoplasm of the nerves, with only a small
      portion from extraneuronal sources.

PMID- 1021225
TI  - Antiestrogen-induced remissions in stage IV breast cancer.
AB  - Tamoxifen (NSC-180973, ICI-46474), an antiestrogen, was administered to 39 women
      with stage IV breast cancer at a dose of 20 mg orally every 12 hours. Patients
      were selected as eligible for endocrine ablative treatment and with disease not
      so aggressive as to jeopardize further treatment in case the experimental drug
      failed. Objective remission was obtained in 19 patients (49%) with a mean
      duration of 11+ months and ten patients are still in remission. No progression
      was seen in seven patients (18%) lasting 13+ months with only one patient in
      relapse. Thirteen patients (33%) have failed. Objective remission was obtained in
      two premenopausal women even though menstrual cycles were not suppressed;
      bilateral oophorectomy in one of these patients induced a second remission after
      relapse from tamoxifen. Objective remissions were obtained in two women with
      proven complete hypophysectomy a direct action of antiestrogens at the tumor
      level. Positive estrogen receptors were suggestive of being a good predictor of
      response. Menopausal status and dominant site of metastasis did not affect the
      response to tamoxifen in this small series. Tamoxifen did not alter prolactin
      secretion, and side effects from the drug were usually mild and transient in
      nature. We conclude that tamoxifen is an effective antitumor agent in patients
      with stage IV breast cancer; further studies are necessary to determine whether
      it will equal the therapeutic effect of oophorectomy, adrenalectomy, and
      hypophysectomy.

PMID- 1021226
TI  - Evaluation of tamoxifen dose in advanced breast cancer: a progress report.
AB  - The results of an ongoing trial randomizing patients with progressive, metastatic
      breast carcinoma between tamoxifen (Tam, NSC-180973) and Tam plus fluoxymesterone
      (Flu) (7 mg/m2 bid) are reported. Each patient received a single dose level of
      Tam in the range of 2-100 mg/m2 bid. The combination had a higher response rate
      overall (45% vs 28%) and when only the patients' soft tissue sites were analyzed
      (54% vs 9%, P=0.04). The time to treatment failure was longer for the combination
      among those patients with a response or disease stabilization (P=0.08). Response
      rates with Tam doses less than 12 mg/m2 bid were also higher than with doses
      greater than or equal to 12 mg/m2 for all patients in the study (62% vs 30%,
      P=0.025) and for those where only soft tissue sites were evaluable (43% vs 29%,
      P=0.07). Side effects were mild and consisted primarily of transient hematologic
      suppression, nausea, masculinization, hepatic enzyme elevations, and edema. The
      latter three were observed only with the Flu regimen. Leukopenia and
      thrombocytopenia were more frequent at Tam doses less than 12 mg/m2 bid whereas
      nausea was more common at higher doses. Tam doses as high as 100 mg/m2 bid were
      well tolerated. Tam amy be more effective at low doses, has only mild side
      effects, and is well tolerated at doses up to 100 mg/m2 bid. Combining Tam with
      Flu appears to enhance the therapeutic effectiveness.

PMID- 1021227
TI  - Current overview of EORTC clinical trials with tamoxifen.
AB  - Based upon concepts derived from estrogen receptor studies, a phase II
      exploratory trial was conducted where tamoxifen (NSC-180973) was administered
      concomitantly with cytotoxic chemotherapy in postmenopausal patients with
      advanced breast cancer. Chemotherapy was composed of two 28-day cycles given
      alternatively. Cycle A consisted of adriamycin and vincristine, and cycle B
      consisted of cyclophosphamide, methotrexate, and 5-fluorouracil. Fifty-five
      patients were fully evaluable. Complete remissions were obtained in 13 (24%) and
      partial objective remissions in 27 (49%). The overall remission rate was 73%.
      Toxic side effects ranged from mild to severe. The most significant were nausea
      and vomiting (most patients), weakness and pain (two thirds of the patients), and
      hematologic changes (half of the patients). It is concluded that the present
      combination of endocrine and cytotoxic therapy represents one of the most
      effective currently available treatments of advanced breast cancer. In an early
      clinical trial of tamoxifen in premenopausal patients with advanced breast
      cancer, two objective remissions, lasting 5 and 9+ months respectively, were
      obtained in ten patients treated. Tamoxifen is worthy of further assessment in
      premenopausal patients.

PMID- 1021228
TI  - Histologic classification of lung cancer.

PMID- 1021229
TI  - Occurrence of lung cancer according to stage and determination of its
      dissemination.

PMID- 1021231
TI  - Prerequisties for effective radiotherapy for lung cancer.

PMID- 1021230
TI  - General principles of surgical treatment of lung cancer.

PMID- 1021232
TI  - Experience with combination chemotherapy and radiotherapy for undifferentiated
      lung cancer.

PMID- 1021233
TI  - 5-Fluorouracil (5-FU), methyl-CCNU, and vincristine in the treatment of advanced
      colorectal cancer: phase II study utilizing weekly 5-FU.
AB  - We report a phase II trial of 5-fluorouracil (5-FU), methyl-CCNU, and vincristine
      (FMV) combination chemotherapy in advanced colorectal carcinoma. Ten of 25
      patients (40%) achieved an objective tumor regression after treatment with FMV
      chemotherapy. The main toxicities of FMV were hematologic and gastrointestinal. 5
      FU was administered in a weekly rather than a loading-dose schedule which allowed
      for sensitive adjustment of drug dosages according to hematologic toxicity; only
      16% of the patients (four of 25) had a wbc count less than 2000 cells/mm3. FMV is
      significantly more active than 5-FU alone in the treatment of advanced colorectal
      cancer; however this regimen does not significantly improve survival in
      responding patients.

PMID- 1021234
TI  - Combination chemotherapy in vitro with cis-dichlorodiammineplatinum(II).
AB  - Cis-dichlorodiammineplatinum(II) (DDP) was paired with 11 other chemotherapeutic
      drugs in a search for possible synergistic pairs. Cell lethality was investigated
      by the colony-formation technique utilizing a long-term culture of human lymphoma
      cells. Synergistic effects were noted for pair combinations with all alkylating
      agents, bleomycin, adriamycin, camptothecin, and cytosine arabinoside. Additive
      effects were recorded for combinations with prednisolone and VP-16-213, while DDP
      reduced the capacity of cells to absorb sublethal damage induced by alkylating
      agents.

PMID- 1021235
TI  - Inhibition of growth and regression of a transplantable rat chondrosarcoma by
      three retinoids.
AB  - An aromatic analog of retinoic acid, all-trans-9-(4-methoxy-2,3,6
      trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoic acid (Ro 10-1670), its ethyl
      esther (Ro 10-9359), and ethyl amide (Ro 11-1430) have been shown to inhibit the
      growth of a transplantable rat chondrosarcoma. The inhibition observed occurred
      over a range of tolerated doses. At the higher tolerated dose levels, significant
      regressions of already established tumors were observed. All three compounds were
      active when administered ip for 2 or 4 weeks. The ethyl ester, Ro 10-9359, and
      the etyl amide, Ro 11-1430, were also active when administered for 4 weeks as
      dietary admixes. In the latter experiments, both compounds were equally effective
      at tolerated doses, but Ro 11-1430 was less toxic than Ro 10-9359 at higher
      doses.

PMID- 1021236
TI  - Evaluation of daunorubicin in adenocarcinoma of the large intestine.

PMID- 1021237
TI  - Comparative nephrotoxicity of platinum cancer chemotherapeutic agents.

PMID- 1021238
TI  - Phase II evaluation of cis-diamminedichloroplatinum(II) in lung cancer.

PMID- 1021239
TI  - Phase II study of VP-16-213 versus dianhydrogalactitol in patients with
      metastatic malignant melanoma.

PMID- 1021240
TI  - Adriamycin and CCNU in the treatment of advanced breast cancer.

PMID- 1021241
TI  - Pulmonary toxicity in long-term administration of BCNU.

PMID- 1021242
TI  - Color reaction of cholesterol with benzoyl peroxide in concentrated
      trichloroacetic acid.

PMID- 1021243
TI  - Stereospecific introduction of deuterium into ring D of estrogens.

PMID- 1021244
TI  - Chemical and biochemical studies on carbohydrate esters. II. Antitumor activity
      of saturated fatty acids and their ester derivatives against Ehrlich ascites
      carcinoma.

PMID- 1021245
TI  - A facile O-glycosidation using stannic chloride.

PMID- 1021246
TI  - Syntheses of betulafolienetriol and the ginseng sapogenin, 20(S)-protopanaxadiol.

PMID- 1021247
TI  - Studies on the components of the leaves of Coptis japonica Makino. I. The
      structures of coptiside I and II.

PMID- 1021248
TI  - Syntheses of methoxyestrogen glucuronide acetate-methyl esters.

PMID- 1021249
TI  - Conversion of dehydroabietic acid into a steroid skeleton: formation of the A
      ring. III.

PMID- 1021250
TI  - Metabolism of piromidic acid, a new antibacterial agent. II. In vitro metabolic
      pathway of piromidic acid in rats.

PMID- 1021251
TI  - Maridomycin, a new macrolide antibiotic. X. The structure of maridomycin II.

PMID- 1021252
TI  - Maridomycin, a new macrolide antibiotic. XI. The structures of maridomycin
      components.

PMID- 1021253
TI  - Effect of drugs on human erythrocytes. I. Morphological changes and increase in
      fragility of erythrocytes treated with drugs.

PMID- 1021254
TI  - Color reaction of cholesterol with the antimony trichloride reagent.

PMID- 1021255
TI  - Studies on the synthesis of azabicyclo[3,3,1]non-6-enes by the novel cyclization
      reaction of tetrahydropyridines with Lewis acid.

PMID- 1021256
TI  - Studies on peptides. LVIII. Synthesis of Tyr1-substance P.

PMID- 1021257
TI  - On the heterogeneity of eukaryotic ribosomal subunits in vitro.

PMID- 1021258
TI  - Synthesis of optically active prenylamine from (-)-norephedrine.

PMID- 1021260
TI  - Benzodiazepine. XIII. Syntheses of 1,4-benzodiazepine derivatives.

PMID- 1021259
TI  - Synthetic chemotherapeutic agents. IV. Synthesis of 3-substituted thiazolo[5,4
      f]quinoline derivatives.

PMID- 1021261
TI  - Studies on anticoccidial agents. VII. An improved synthesis of alpha4
      norpyridoxol.

PMID- 1021262
TI  - A fluorophotometric method for the determination of pyridoxal and its phosphate
      by using glycine and zinc(II) ion.

PMID- 1021263
TI  - Preparation of yeast mannan derivatives by stearoylation and phosphorylation.

PMID- 1021264
TI  - Synthesis of [27-Tyr]-cholecystokinin-pancreozymin (CCK-PZ).

PMID- 1021265
TI  - Antitumor polysaccharide fraction from Sargassum thunbergli.

PMID- 1021266
TI  - Occurrence of bufalitoxin, cinobufotoxin and their homologs in Japanese toad.

PMID- 1021267
TI  - Fukinotoxin, a new pyrrolizidine alkaloid from Petasites japonicus.

PMID- 1021268
TI  - Synthesis and properties of S-aminomethylthiamine and N-hydroxymethylthiamine.

PMID- 1021269
TI  - The reaction of S-aminomethylthiamine with acid anhydride--the synthesis of O,S
      bis(alpha-aminoacyl)thiamine.

PMID- 1021270
TI  - Color reaction of cholesterol in concentrated trichloroacetic acid media.

PMID- 1021271
TI  - Biopharmaceutical study of the hepato-biliary transport of drugs. IV. Development
      of the method to investigate the process of the active secretion of drugs from
      the hepatocytes into the bile canaliculi and its application to the biliary
      excretion of organic anions in rat.

PMID- 1021272
TI  - Biopharmaceutical study of the hepato-biliary transport of drugs. V. Hepatic
      uptake and biliary excretion of organic cations.

PMID- 1021273
TI  - Factors influencing absorption and excretion of drugs. V. Further study on effect
      of potassium ion on in situ rat intestinal absorption of drugs.

PMID- 1021274
TI  - Chemical reactivity of morphine and morphine-6-conjugates and their binding to
      rat brain.

PMID- 1021275
TI  - Studies on sperm capacitation. V. Characterization of decapacitation factor from
      guinea-pig spermatozoa.

PMID- 1021276
TI  - Effect of ginseng extract on lipid and sugar metabolism II. Nutritional states in
      rats.

PMID- 1021277
TI  - Effect of biotin on biochemical changes following isoproterenol-induced
      myocardial infarction in rats.

PMID- 1021278
TI  - Aminomethylation of thiamine disulfides and formation of cyclobis
      methylenethiamine from N-aminomethylated thiamine disulfide.

PMID- 1021279
TI  - Absorption, distribution, excretion, and metabolism of 1-(5-oxohexyl) theobromine
      (BL 191) in rats.

PMID- 1021280
TI  - Inclusion complexation of barbiturates with beta-cyclodextrin in aqueous
      solution. I. Spectroscopic study on the mode of interaction.

PMID- 1021281
TI  - Simultaneous determination of complexation equilibrium constants for conjugated
      guest species by extended potentiometric titration method: on barbiturate-beta
      cyclodextrin system.

PMID- 1021282
TI  - Polymorphism of phenylbutazone.

PMID- 1021283
TI  - Studies on psychotropic agents. I. Synthesis of 3,8-disubstituted-1-oxa-3,8
      diazaspiro[4,5]decan-2,4-dione derivatives.

PMID- 1021284
TI  - Motional state of spin-labeled stearates in lecithin-cholesterol liposomes and
      their incorporation capability.

PMID- 1021285
TI  - Studies on the syntheses of analgesics. XLVI. An abnormal Hofmann degradation of
      N-(4-hydroxybenzyl)-3-benzazocinium halides (studies on the syntheses of
      heterocyclic compounds. DCLXVIII).

PMID- 1021286
TI  - Spectrophotometric determination of quinine, emethine and ephedrine in
      pharmaceutical preparations with tetrabromophenolphthalein ethyl ester by solvent
      extraction.

PMID- 1021287
TI  - Color reaction of estrone with the antimony trichloride reagent.

PMID- 1021288
TI  - Analytical studies on mepirizole and its metabolites. IV. Quantitative
      determination of mepirizole in human serum by mass fragmentography, and isotope
      effect on drug metabolism.

PMID- 1021289
TI  - One step syntheses of adenine, xanthine and guanine from phenylazomalonic acid
      derivatives.

PMID- 1021290
TI  - Anticholinergic agents. Synthesis of 1,1,4-trimethyl- and 1,1,5- trimethyl-3
      diphenylmethylenepyrrolidinium halides.

PMID- 1021291
TI  - Anticholinergic agents. Synthesis of 4-diphenylmethylene-1,1,2,3
      tetramethylpyrrolidinium iodide.

PMID- 1021292
TI  - Metabolism and excretion of aminopyrine in man.

PMID- 1021293
TI  - Aryl hydroxylation of 3-methylacetanilide[4-2(3)H] by several model systems.

PMID- 1021294
TI  - Synthesis of 6 beta-bromomethyl-and 6 beta-chloromethyl-19-norcholest-5(10)-en-3
      beta-ol.

PMID- 1021295
TI  - Isolation of 4 beta-hydroxywithanolide E, a new withanolide from Physalis
      peruviana L.

PMID- 1021296
TI  - Studies on prostaglandins. III. Synthesis of bicyclo[4.3.0]nonane derivatives.

PMID- 1021297
TI  - [Acute abdomen caused by gynecologic diseases].

PMID- 1021298
TI  - [In vitro thyroid diagnosis in surgery of the thyroid].
AB  - After a brief outline of the physiology of the thyroid hormones and the
      laboratory tests measuring thyroid function, the dosage of normalised T4 (T4N) in
      patients suffering from various thyroid diseases and subjected to surgical
      operation is discussed. As the fundamental presupposition of thyroid surgery is
      that the operation is made in conditions of euthyroidism, the use of a quick and
      reliable preoperative test giving an exact evaluation of the patient's
      thyrometabolic conditions is necessary. In conclusion it is stated, on the basis
      of experience acquired in 90 patients operated for various thyriod diseases, that
      the last thyrometabolic evaluation can be based on T4N dosage.

PMID- 1021299
TI  - [Revascularization surgery in aorto-iliac insufficiency].

PMID- 1021300
TI  - [Observations on 7 cases of chronic celiaco-mesenteric ischemia].

PMID- 1021301
TI  - [Senile pancreatic duct patterns].

PMID- 1021302
TI  - [A case of intestional duplication at the level of the sigmoid discovered in an
      adult].

PMID- 1021303
TI  - [Mediastinal thymoma. Remarks on a case].

PMID- 1021304
TI  - [Peritoneal lavage for diagnostic purposes].

PMID- 1021305
TI  - [1st clinical uses of a new vascular prosthesis made of velour rodergon].

PMID- 1021306
TI  - [35 cases of suprapubic urinary diversion].

PMID- 1021307
TI  - [Organizational problems and clinical experience in emergency surgery and first
      aid].

PMID- 1021308
TI  - [Exposure of the surgeon to ionizing radiations during intraoperative
      cholangiography].

PMID- 1021309
TI  - [Xeroarthrography of the knee].

PMID- 1021310
TI  - [Fluorescein telechronoangiography].

PMID- 1021311
TI  - [Detachment of the retina caused by multiple serous detachments of the pigment
      epithelium].

PMID- 1021312
TI  - [Fundus flavimaculatus modified suddenly by carotid arteriography].

PMID- 1021313
TI  - [Use of the vitreophage for repair of the anterior segment].

PMID- 1021314
TI  - [Use of Kloti's vitreotome in the treatment of thick membranules and secondary
      cataracts after congenital cataracts].

PMID- 1021315
TI  - [Difficulties in the classification and treatment of acute ocular hypertonia].

PMID- 1021316
TI  - [Action of anthocyanosides and vitamin A on the electro-oculogram of normal
      subjects].

PMID- 1021317
TI  - [Oculonystagmographic stimulation rail derived from Maddox's cross].

PMID- 1021318
TI  - [2 cases of sclerectasia].

PMID- 1021319
TI  - [Immune reactions in superficial herpetic keratitis. Study of a series of 47
      cases].

PMID- 1021320
TI  - [Clinical forms of aniridia and associated ocular disorders in the same family].

PMID- 1021321
TI  - [Keratosis follicularis spinulosa decalvans].

PMID- 1021322
TI  - [Detachment of the choroid and chorioretinal surgery].

PMID- 1021323
TI  - [Septic disease of the posterior segment. Problems of diagnosis and treatment.
      Apropos of 3 cases].

PMID- 1021324
TI  - [2 cases of Horton's disease. Typical ocular symptology. Histological
      confirmation].

PMID- 1021325
TI  - [Hypertensive uveitis with hemorrhagic hypopyon revealing chronic lymphoid
      leukemia (discussion of a case)].

PMID- 1021326
TI  - [Local anesthesia in ophthalmology].

PMID- 1021327
TI  - The immunology of acute and chronic hepatitis.

PMID- 1021328
TI  - [Treatment of obesity in infancy and adolescence. III. Long-term results of
      dietetic and pharmacologic therapy].

PMID- 1021329
TI  - [Studies of the therapeutic effect of sulpiride in the ulcer disease].

PMID- 1021330
TI  - [Subacute or progressive myocardial infarcts. Gradual or delayed installation of
      Q waves in coronary patients].

PMID- 1021331
TI  - [Atheromatous aneurysms and megadolicho-coronary arteries in adults].

PMID- 1021332
TI  - [Risks of hemodynamic exploration in infectious endocarditis].

PMID- 1021333
TI  - [Experimental study of the microcirculation in revascularized myocardial infarct
      in rats].

PMID- 1021334
TI  - [Assessment of left ventricular function by echocardiography].

PMID- 1021335
TI  - [Antihypertensive treatment and anesthetic risk].

PMID- 1021336
TI  - [Hemodynamic study of the action of carbocromen in the acute stage of myocardial
      infarct].

PMID- 1021337
TI  - [Echographic diagnosis of compressive pericardial effusion].

PMID- 1021338
TI  - [Intramyocardial hydatid cysts (2 cases and review of the literature)].

PMID- 1021339
TI  - [Benign paroxysmal ventricular tachycardia. Development over 30 years].

PMID- 1021340
TI  - [Cardiac and skeletal rhabdomyolysis during a coma caused by drug poisoning].

PMID- 1021341
TI  - Lymphomatoid contact dermatitis: a syndrome produced by epicutaneous
      hypersensitivity with clinical features and a histopathologic picture similar to
      that of mycosis fungoides.
AB  - Four cases have been studied which were clinically suggestive of mycosis
      fungoides because of their infiltrated plaque-like lesions, but in which the
      suspicion of a topical hypersensitivity arose when a positive patch test was
      obtained with the striker part of a box of matches.

PMID- 1021342
TI  - An antigen from Parthenium hysterophorus Linn.
AB  - The increasing incidence of contact dermatitis due to the wild growth of the weed
      Partheium hysterophorus Linn. in many parts of India has prompted chemical
      analysis coupled with clinical testing to isolate the offending agent. Results
      are present to show that parthenin, a sesquiterpene lactone, is the major antigen
      which produces contact dermatitis in sensitive human beings.

PMID- 1021343
TI  - The effect of perfume "ageing" on the allergenicity of individual perfume
      ingredients.
AB  - An ingredient of a perfume which is a sensitizer may become hypoallergenic by
      interacting with other ingredients during the ageing process of the perfume.
      Thus, a patient with an exquisite allergic sensitivity to cinnamic aldehyde
      tolerates two perfumes containing cinnamic aldehyde without acquiring a
      dermatitis. There are several theories of why cinnamic aldehyde can become a non
      sensitizer in a perfume mixture. Testing with a mature perfume may be much more
      significant than testing with individual ingredients.

PMID- 1021344
TI  - Quinazoline Yellow SS in cosmetics.
AB  - Five cases of allergic contact dermatitis from Quinazoline Yellow SS (D and C
      Yellow 11) in cosmetics are described, three from a lipstick and two from a rouge
      stick. Four of them showed marked oedema spreading to the eyelids and down to the
      neck. Two of them required systemic steroids. All four had strongly positive
      patch tests to the dye and to the cosmetic used.

PMID- 1021345
TI  - Transepidermal water loss in adhesive tape induced dermatitis.
AB  - As an index of skin barrier function, transepidermal water loss (TEW) was
      investigated in subjects reactive to adhesive tapes. Tape reactive subjects
      showed no difference in TEW in untreated skin when compared to non-reactive
      subjects. Plastic tape and transparent tape produced varying degrees of
      dermatitis in reactive subjects; the TEW was increased up to 40-fold of the
      baseline values correlating with the degree of dermatitis. Paper tape and plastic
      film without adhesive did not produce dermatitis and increased water loss.
      Regeneration of skin damage was accompanied by a decrease of TEW values. The
      general problem of tape reactors and tape irritation is discussed.

PMID- 1021346
TI  - Thioridazine photosensitivity.

PMID- 1021347
TI  - Positive patch test to the azo-dye tartrazine.

PMID- 1021348
TI  - Clinical investigation on the local protective effect of antihuman-lymphocyte
      globulin in contact allergy.

PMID- 1021349
TI  - Sensitivity to 35 essential oils.
AB  - Two hundred consecutive patients and 50 subjects positive to balsams were tested
      with the 35 essential oils most frequently used in Polish cosmetics. The
      frequency of sensitivity to the particular oils is noted and the index of
      sensitization calculated as the amount of oil/kg used annually for the production
      of Polish cosmetics per one patient positive to this oil. The correlation of
      positive tests to essential oils with positive tests to four balsams of the
      standard series is shown.

PMID- 1021350
TI  - Contact sensitivity to emulsifiers.
AB  - Common emulsifiers were tested in over 1,200 patients with eczema.
      Triethanolamine stearate tested at 5% in petrolatum caused irritant reactions in
      9.5% of the patients. On the other hand, non-ionic emulsifying agents tested at
      10-20% produced irritation in only a few cases. Allergic reactions were found in
      2.1% of those tested. Lanette, sorbitan sesquioleate, the Spans, polyoxyethylene
      oxypropylene stearate, polyoxyethylene sorbitol lanolin derivative, and
      triethanolamine stearate each elicited allergic reactions in 0.3-0.7% of the
      cases. The Tweens caused an allergy in only two cases, but glycerol monostearate
      caused no reaction at all. Five out of six patients sensitive to sorbitan
      sesquioleate reacted positively to the Spans as well. The patients allergic to
      one or more emulsifiers were also sensitive to several other substances included
      in our routine test series with the exception of four patients who reacted only
      to the emulsifying agents.

PMID- 1021351
TI  - Standardization of patch tests in Japan.
AB  - In order to standardize patch tests in Japan a comparative study of our former
      method of patch testing with that recommended by the International Contact
      Dermatitis Research Group (ICDRG) was carried out with the collaboration of
      dermatologists in the Mid-Japan Dermatological Society. The following differences
      were observed between the two methods of patch testing: 1. Four out of five ICDRG
      allergens which were common in Japanese standard allergen series--formaldehyde,
      potassium dichromate, cobalt chloride and nickel sulfate--showed higher
      reactivity than those of Japanese allergens. The other allergen,
      paraphenylenediamine (PPD), showed the same reactivity as Japanese PPD. Cobalt
      chloride of ICDRG origin showed a particularly higher reactivity than the
      Japanese one (a=0.05) 2. Higher reactivity was observed at the 48-h reading when
      aqueous reagents were patch-tested using Torii-Ban, Miniplaster and Leukotest,
      which are all popular in Japan. This higher reactivity could be attributed to the
      lint gauze of plasters which are pre-treated with fluorescent whitener. 3. The
      incidence of reactivity of the ICDRG allergens in Japan was also studied in order
      to establish a new standard allergen series.

PMID- 1021352
TI  - Photoepicutaneous testing: influence of the vehicle, occlusion time and
      concentration of the test substances on the results.
AB  - The effects of various vehicles, the occlusion time and the concentration of the
      test substances on the phototoxic reactions were studied using the Finn Chamber
      method in photoepicutaneous testing, with methoxsalen and coal tar as test
      substances. Petrolatum proved to be a suitable base for methoxsalen and carbowax
      for coal tar. The optimal concentration of coal tar was 5% and that of methoxalen
      0.03-0.05%. The optimal occlusion time for methoxsalen was 1-2 hours and for coal
      tar 24 hours. It was concluded that in order to obtain the most reliable results,
      these parameters should be determined separately for every photosensitizing
      compound to be tested.

PMID- 1021353
TI  - Thiuram-mix.

PMID- 1021354
TI  - [Unusual localization of eosinophilic granuloma : epidural spinal space].

PMID- 1021355
TI  - [Monteggia's lesions in the child].

PMID- 1021356
TI  - [Hyperplasia of Pacini's corpuscles (presentation of a case)].

PMID- 1021357
TI  - [The Paci-Lorenz technic : poor record of the past (revision of 628 treated
      hips)].

PMID- 1021358
TI  - [A case of isolated paralysis of the serratus magnus muscle].

PMID- 1021359
TI  - [Our experience in the surgical treatment of tibio-tarsal fractures].

PMID- 1021360
TI  - [2 cases of nonfamilial ulcero-mutilating acropathy of the hands].

PMID- 1021361
TI  - [Post-traumatic ossifications of the elbow and radiotherapy].

PMID- 1021362
TI  - [Case of benign osteoblastoma of the astragalus].

PMID- 1021363
TI  - [An unusual case of bilateral abduction rigidity of the scapulo-humeral joint due
      to congenital fibrous retraction of the deltoid muscle].

PMID- 1021364
TI  - [Our experience in surgical treatment of chronic pancreatitis. Apropos of 214
      operations].

PMID- 1021365
TI  - [The problem of the remaining limb in the amputee with arteritis. Prognostic and
      therapeutic study of 256 cases].

PMID- 1021366
TI  - [Chylothorax caused by a closed injury. Apropos of a case].

PMID- 1021367
TI  - [Hemodynamic arteriosclerosis. Localization and surgical treatment].

PMID- 1021368
TI  - [Solitary biliary cysts of the liver. Apropos of 5 cases].

PMID- 1021369
TI  - [Treatment of certain pseudarthrosis of the carpal scaphoid by partial silicon
      prosthesis cast in situ].

PMID- 1021370
TI  - [Acute renal failure due to biliary tract infections].

PMID- 1021371
TI  - [Surgery in the child with motor deficit of cerebral origin. Indications and
      functional results].

PMID- 1021372
TI  - [Cardio-esophageal manometry in the pre- and postoperative study of hiatal
      hernia].

PMID- 1021373
TI  - [Tears of the iliac vein in fractures of the pelvis with major displacement.
      Mechanism of the injury and surgical technic].

PMID- 1021374
TI  - [Enzyme induction in the liver].

PMID- 1021375
TI  - [Morphology and differential diagnosis of primary biliary cirrhosis and its pre
      stages].

PMID- 1021376
TI  - [Studies of surface- and nuclear antigens in the liver punctate].

PMID- 1021377
TI  - [Our experiences with the immunosuppressive treatment of chronic active
      hepatitis].

PMID- 1021378
TI  - [Partigen identity of erythrocyte stroma and hepatitits B antigen].

PMID- 1021379
TI  - [Aspects of serum immunoglobulins in chronic hepatitis].

PMID- 1021380
TI  - [Monoclonal immunoglobulins in chronic liver diseases].

PMID- 1021381
TI  - [CEA content of the gastric juice in comparison with histological and macroscopic
      findings in the gastric mucosa].

PMID- 1021382
TI  - [Immunosuppressive treatment of Crohn's disease].

PMID- 1021383
TI  - [Liver histology in various forms of portal hypertension].

PMID- 1021384
TI  - [Various changes of blood coagulation in portal hypertension].

PMID- 1021385
TI  - [Reinfusion of ascitic fluid in the treatment of ascites due to cirrhosis].

PMID- 1021386
TI  - [Clinical aspects and diagnosis of the Budd-Chiari syndrome].

PMID- 1021387
TI  - [Diet therapy of patients with portacaval anastomosis].

PMID- 1021388
TI  - [EEG findings in portosystemic encephalopathy during current conservative
      treatment].

PMID- 1021389
TI  - [Morphological and clinical findings in inflammatory diseases of the large
      intestine].

PMID- 1021390
TI  - [Double-contrast demonstration of the colon as a basic radiographic examination].

PMID- 1021391
TI  - [Coloscopy an important diagnostic progress in the diagnosis of unspecific
      colonic diseases].

PMID- 1021392
TI  - [Diagnosis and clinical aspects of ischemic colitis].

PMID- 1021393
TI  - [Biopsy assessment of benign and malignant polyps of the large intestine].

PMID- 1021394
TI  - [Progress and failure of clinical diagnosis in gastroenterology].

PMID- 1021395
TI  - [Dispensatory care for gastrointestinal diseases].

PMID- 1021396
TI  - [Organization of special care for gastrointestinal diseases].

PMID- 1021397
TI  - [Gastrointestinal polypectomy].

PMID- 1021398
TI  - [Chronic gastritis and life expectancy].

PMID- 1021399
TI  - [Serum gastrin levels in chronic kidney lesious].

PMID- 1021400
TI  - [Surgical treatment of extreme obesity].

PMID- 1021401
TI  - [Diet of the astronauts as a prerequisite for surgery of the large intestine].

PMID- 1021402
TI  - [Elastolytic activity of the human duodenal content].

PMID- 1021403
TI  - [Changes of the exocrine pancreatic function and results of secretin therapy in
      duodenal ulcer].

PMID- 1021404
TI  - [Modification of the biliary dissolving capacity for cholesterol using bile-duct
      diagnostics].

PMID- 1021405
TI  - [Comparative study of the mutagenic effect of several chemical substances on
      Syrian hamsters].
AB  - The authors carried out experiment on 38 Syrian hamsters, treated with cyneb,
      tetracycline and chlorpromasine in groups for a period of tree days. They
      examined the changes in the cariotypes of the animals as well as the changes in
      the mytotic activity of bone-marrow cells. Data were based on the analysis of
      3045 metaphasic plates and 190,000 cells. It was established that the examined
      substances possessed mutagenic effect on the Syrian hamster in doses applied in
      vivo. This effect was mostly manifected in the animals treated with cyneb,
      followed by chlorpromasine and tetracycline. The same chemical substances reduced
      the mytotic activity of the bone-marrow cells. The data of the experiments in
      vivo correlated positively with the results of the experiments in vitro of human
      lymphocytic cultures, treated with the indicated substances.

PMID- 1021406
TI  - [Morphologic changes in the testes of white rats chronically subjected to vofatox
      50].
AB  - The chronic action of the preparation vofatox 50 causes changes in the
      spermatopoeitic epithelium of white rats, which depend on the doses and duration
      of intoxication. There is an increased vascular permeability and degenerative
      changes in the spermatogenic epithelium, a reduction of the mitotic process and
      also index of spermatogenesis at the initial stages. The later changes are
      manifested by more formed changes in the spermatopoietic cells, appearance of
      gigantic multicellular forms, lack of sprematozoa in a large number of
      canaliclues and fibrosis of blood vessels. The changes in the testis are the
      result of the general toxic action of the preparation.

PMID- 1021407
TI  - [Biochemical changes in the placenta of white rats treated with basfungin].
AB  - The author carried out experiments on white rats and discussed the role of the
      placental insufficiency in the perinatal pathology under the action of fungicide
      basfugine. After administration of the preparation singly at the critical 13th
      day of embriogenesis and repeatedly during the course of the gestation the author
      examined biochemically the activity of the following enzymes: glucose-6
      phosphatdehydrogenase, lactatdehydrogenase and thermostable alkaline phosphatase.
      Basfungine, administered in effective teratogenic doses, inhibited the activity
      of the indicated enzymes in the placenta, manifesting in this way its functional
      insufficiency, which was most probably the substantial moment in the pathogenesis
      of the induced anamaly in the fetal development.

PMID- 1021408
TI  - [Formation and development of motor-defense conditioned reflexes in rats of
      different ages].
AB  - The analysis of the reflex conditioned activity of rats at various age groups
      showed that there were differences in it. There was a considerable strength of
      the excitatory process in young rats, aged one and a half months. The positive
      reflexes to sound and light stimuli were formed compatively quickly (on the
      average after 8,6 and 4,8 combinations of the conditioned stimulus with the
      unconditioned stimulus) in comparison with the animals of mature age
      (respectively 16,5 and 8 combinations). In the old rats the author observed a
      lowering of the strength of the excitatory process and slower formation and
      stabilization of the positive conditioned reflexes. A gradual formation of the
      inhibitory function occurs during the process of ontogenetic development and this
      finds an expression in the unpossibility for the fromation of differentiation in
      young animals and the presence of such in 10-month old rats. The level of the
      differentiations in these animals reached 60,1% and 76,9%. The latent period
      changed with the advancement of age. In adult animals there was some shortenint
      ofthelatent period in comparison with the young animals although the difference
      was statistically insignificant. There was an increase of the absolute values of
      the latent period again after the occurrence of the old age (5,2'' and 4,52'').
      The indicated peculiarities in the formation and course of the conditioned
      reflexes probably were connected with various degree in the fluctuations of the
      strength of the exitiatory and inhibitory processes in the central nervous system
      during ontogenesis.

PMID- 1021409
TI  - [Changes in renal enzyme activity in rats with experimental hypertension].
AB  - The study was carried out on rats of the Wistar strain with experiments
      hypertension by the method of Selye, modified by Kolarova. These authors examined
      the activity of the enzymes of protein metabolism (GOT, GPT, AP), of glycolysis
      (ALD, LDH, alpha-HBDH) and of the citric cycle (MDH) in the left and right kidney
      at various intervals after modeling the process (3th, 15th, 30th and 90th day).
      The activity of the enzymes of the glycolytic chain and the cycle of Krebs in the
      left kidney was lowered at all stages of the experiment. Transaminase activity
      diminished progressively. Such a dynamics revealed the activity of adenosine
      phosphate as well. The activity of all examined enzymes of the right kidney
      showed phase changes-after initial elevation on the third day there was a
      lowering at the later stages of the experiment. The altered activity off the left
      kidney was connected with the disturbed vascularization with subsequent metabolic
      changes. The changes in the enzymic activity in the right kidney were assumed as
      a consequence of the occurred adaptive hyperfunction.

PMID- 1021410
TI  - [Organ hematocrit and determining the blood content of tissue homogenates].
AB  - The authors determined the mean normal values of organ homogenates and their
      significance in evaluating blood amount, contained in the organs. They used
      radioisotope method with two kers 131 J and 51Cz for determining organ
      hematocrit. The hematocrit values of the organ blood differed significantly from
      the venous hematocrit as the values of the spleen were higher, but those of
      liver, kideny, cerebrum, testis and skeletal muscles-lower. On the basis of these
      data they proposed to apply respective correction factors, checking the
      differences between venous and organ hematocrits, when the amount of blood in
      single organs, determined by hemoglobin content, was estimated. The validity of
      this correction was illustrated by experimental results.

PMID- 1021411
TI  - [Technic for cannulating the great lymph duct in dogs].
AB  - The authors described in details the technique for cannulation of the terminal
      part of the main lymph ductus in dogs. They shared their experience in operating
      23 dogs. The authors described the approach to ductus thoracicus, cervical region
      and most frequent difficulties connected with its finding and preparation. All
      encountered anatomic variants of the chest ductus were presented. The most
      critical moment of the operation--introduction of the cannula in the ductus was
      described in details and the authors proposed some technical methods enhancing
      quicker and easier cannulation.

PMID- 1021412
TI  - Organizational processes in motor control.

PMID- 1021413
TI  - Chlorpromazine and aging in the brain.

PMID- 1021414
TI  - Concentration of sialic acids in submandibular glands of young and old rats
      treated with isoproterenol.

PMID- 1021415
TI  - Changes in rat liver ornithine decarboxylase activity during ageing and effect of
      stimulation by dexamethasone.

PMID- 1021416
TI  - Microsomal mixed-function oxidase activity and senescence--II. In vivo and in
      vitro hepatic drug metabolism in rats of different ages following partial
      hepatectomy.

PMID- 1021417
TI  - Subcellular distribution of renal and hepatic catalase activity in senescent
      rodents.

PMID- 1021418
TI  - Longitudinal and cross-sectional observations of growth and body composition with
      age in laboratory populations of the male annual cyprinodont fish, Nothobranchius
      guentheri.

PMID- 1021419
TI  - Effects of alpha-tocopherol on thiobarbituric acid reactive substances in serum
      and hepatic subcellular organelles and lipid metabolism.

PMID- 1021420
TI  - Age-dependent ploidy class changes in mouse hepatocyte nuclei as revealed by
      Feulgen-DNA cytofluorometry.

PMID- 1021421
TI  - Labeling index (triatiated thymidine) of the synovium of mice at different ages.

PMID- 1021422
TI  - Effects of spontaneous hypertension and age on arterial connective tissue in the
      rat.

PMID- 1021423
TI  - Age dependent changes in body weight, haematocrit and corticosteroids following
      sequential castration in rats with a high incidence of spontaneous tumours.

PMID- 1021424
TI  - An autoradiographic investigation of 3H-uridine utilization by aging mouse
      cartilage cells.

PMID- 1021425
TI  - The structural relationship of phorbol and cortisol: a possible mechanism for the
      tumor promoting activity of phorbol.

PMID- 1021426
TI  - Activation of alpha-carbons of amides.

PMID- 1021427
TI  - Ambivalent effect of protein binding on computed distributions of metal ions
      complexed by ligands in blood plasma.
AB  - Although the absolute concentrations of metal complexes in blood plasma are
      controlled by protein binding, the percentage distribution of transition metal
      ions amongst low molecular weight ligands is not. Thus, computer simulations
      which omit protein equilibria can nevertheless afford reliable information about
      such metals in the biofluid.

PMID- 1021428
TI  - Subcellular localization of O-acetylserine sulfhydrylase in spinach leaves.
AB  - A combination of differential centrifugation and isopycnic sucrose density
      gradient centrifugation of extracts from spinach leaves (Spinacia oleracea L.)
      shows that about 20% of the O-Acetylserine sulfhydrylase are associated with
      chloroplasts. No appreciable amounts of O-Acetylserine sulfhydrylase band with
      mitochondrial and peroxisomal marker enzymes.

PMID- 1021429
TI  - Some properties of cholinesterase of the plant nematode Aphelenchoides ritzema
      boosi.
AB  - Activity and properties of cholinesterase from Aphelenchoides ritzema-boosi, a
      plant feeding nematode, were investigated by testing the reaction of the enzyme
      with different substrates and inhibitors. Butyrylthiocholine was a better
      substrate than propionyl- and acetylthiochine. When compared with mammaliian
      erythrocyte and plasma cholinesterase, the nematode enzyme was found to be
      extremely insensitive towards a number of well-known organophosphorus and
      carbamate inhibitors.

PMID- 1021430
TI  - Interaction between the soluble and particulate neuraminidases of chick liver.
AB  - The sum of the neuraminidase activities found in the isolated soluble and
      particulate fractions of chick liver was considerably higher than that observed
      in the cytoplasmic extract from which these fractions were obtained. Addition of
      increasing amounts of particulate neuraminidase to a constant amount of the
      soluble preparation resulted in a progressive loss of enzyme activity.

PMID- 1021431
TI  - On the nature of protein benzoquinone complexes.

PMID- 1021432
TI  - Synthesis of bradykinin potentiating pentapeptide (BPP5a).

PMID- 1021433
TI  - Light stimulated 'shunt-metabolism' succinate-alpha-ketoglutarate-isocitrate
      cycle and accumulation of citric acid in Aspergillus niger.
AB  - Studies with light of the visible range had shown that light plays significant
      role in the biosynthesis and accumulation of citric acid in Aspergillus niger.
      Accumulation of 14C-labelled carbon atoms in alpha-ketoglutaric, isocitric,
      succinic and glycolic acids in the cultures grown under illumination suggest a
      probable 'shunt-metabolism' leading to the succinate-alpha-ketoglutarate
      isocitrate (SKI) cycle. This shunt metabolism minimizes the accumulation of
      citric acid in cultures due to depletion of intermediates.

PMID- 1021434
TI  - Adriamycin-induced chromosome damage: elevated frequencies of isochromatid
      aberrations in G2 and S phases.
AB  - Analysis of chromosomes from cells treated with adriamycin during G2 and S phases
      showed a high frequency of isochromatid-type of breaks, in addition to the
      expected chromatid breaks. These are interpreted as independent breaks on sister
      chromatids because of preferential effects of the drug in specific chromosome
      regions. The break points are likely to be different, but morphologically such
      breaks would be indistinguishable from isochromatid or chromosome breaks.

PMID- 1021435
TI  - Actinomycin-resistant antiviral activity associated with preparations containing
      chicken interferon.
AB  - Crude and purified preparations containing chicken interferon show a 2fold
      antiviral activity. One is inhibited by actinomycin and leads to total inhibition
      if interferon is added to cells before actinomycin, the other is insensitive to
      actinomycin and leads to partial inhibition if interferon is added simultaneously
      with or after actinomycin.

PMID- 1021436
TI  - Effects of plant hormones on leucine aminotransferase in pea (Pisum sativum).

PMID- 1021437
TI  - [Phagocytosis of liposomes by mouse peritoneal macrophages (author's transl)].
AB  - Uptake of 14C-cholesterol or 3H-cholesterol labelled liposomes, stimulation of
      14C-glucose oxidation, as well as ultrastructural and autoradiographical
      experiments have shown that liposomes are phagocytized by mouse peritoneal
      macrophages. Further results have shown that degradation of liposomes was not
      complete 2h after uptake.

PMID- 1021438
TI  - [Muscle poder media for enumeration of proteolytic microorganisms (author's
      transl)].

PMID- 1021439
TI  - Gonadectomy and growth of Taenia crassiceps (Cestoda) cysticerci in mice.
AB  - Gonadectomy of SWR of both sexes significantly reduced the number of cysticerci
      of Taenia crassiceps, 60 days post infection. There was a significant decrease in
      the total number of larvae and the number of nonbudding individuals,
      corresponding with increased number of budding larvae. This indicates that the
      asexual multiplication of cysticerci in populations from gonadectomized mice was
      inhibited.

PMID- 1021440
TI  - The generation of toxic activity from trypanosoma congolense.
AB  - Trypanosoma congolense organism, on incubation at 20 degrees C for 91/2h, were
      found to generate phospholipase like activity which was capable of mediating
      lysis of both nucleated cells and erythrocytes as well as acute inflammatory
      response on intradermal inoculation.

PMID- 1021441
TI  - Investigations of the toxic effects of Bayer 73 (Bayluscid WP) on eggs and yolk
      sac larvae of Tilapia leucosticta (Cichlidae).

PMID- 1021442
TI  - The influence of early nutrition and environmental rearing on brain growth and
      behaviour.
AB  - Preweaning malnutrition permanently reduced brain size and cellular content but
      in spite of changes in the adrenocotical stress response no learning deficit was
      observed. Differential rearing environments did not influence the effects of
      malnutrition.

PMID- 1021443
TI  - The glycocalyx of the epithelial cells of the colon, observed in normal and
      ulcerous colitic conditions.
AB  - Biopsies of subjects affected by ulcerous colitis were stained with ruthenium
      Red. Alterations of the cellular coat and glycocalyx of the epithelial cells of
      the colon were identified.

PMID- 1021444
TI  - Modification of visual signals by nigral stimulation.
AB  - Responses of the lateral geniculate neurons to light were modified by stimulation
      of the substantia nigra. Nigral stimulation often caused enhancement of firing in
      neurons responding primarily to flash, but it usually had the contrary effect on
      units inhibited by light.

PMID- 1021445
TI  - Study of the characteristics of the inotropic effect of insulin in rabbit
      papillary muscle.
AB  - The effect of insulin was examined with emphasis on the alteration in the force
      frequency relation. The results show that insulin does not change the time to
      peak tension nor the time of contraction. The inotropic effect was significant
      and did not depend upon the frequency of stimulation. However, there was a
      definite dependence of the magnitude of the inotropic effect on temperature.
      Previous studies have indicated that the inotropic effect is not a result of
      increased substrate availability or changes in cAMP phosphodiesterase activity.
      These results and those reported here are consistant with the hypothesis that
      insulin's inotropic effect is due to increases in intracellular Ca++.

PMID- 1021446
TI  - Reticular potentials evoked by electrical stimulation of individual semicircular
      canals.
AB  - Responses of pontine reticular formation neurons following single shock
      electrical stimulation of single semicircular canals were recorded with tungsten
      microelectrodes in 40 curarized guinea-pigs. The field and unitary potentials
      obtained from 62 reticular sites, exhibited latency values ranging from 0.3 to
      2.5 msec. The early latencies (0.3-0.5 msec) have been interpreted as responses
      mediated by primary vestibular fibres projecting directly to the reticular
      substance.

PMID- 1021447
TI  - Effects of three synthetic peptides analogous to neurophypophyseal hormones on
      the excitability of giant neurones of Achatina fulica Ferussac.
AB  - Deamino-dicarba-(D-D)oxytocin and D-D-Arg-vasotocin at 10(-4)Kg/l showed an
      excitatory effect on the periodically oxcillating neurone (PON) of Achatina
      fulica Ferussac. D-D-Arg-vasopressin had no effect.

PMID- 1021448
TI  - Metabolism of a biliary metabolite of phenacetin and other acetanilides by the
      intestinal microflora.

PMID- 1021449
TI  - Potentiation by taurine of the inotropic effect of ouabain and the content of
      intracellular Ca++ and taurine in the heart.
AB  - Under certain conditions, taurine (3.0mM) potentiated cardiac contractile
      response to ouabain in the normal medium. The potentiation by taurine was also
      observed in the low K+ medium, in which the positive inotropic effect of ouabain
      increased. The potentiation as seen in both media was, at least in part, due to
      the increase by taurine of Ca++ content in the heart. Taurine in the heart was
      not directly related to this potentiation.

PMID- 1021450
TI  - [Microscopical investigations on the 'vessel sealing' effect of calcium ions
      (author's transl)].
AB  - The effect of locally applied calcium on the vascular permeability is studied
      under the conditions of an acute inflammatory reaction. Using the Sephadex
      inflammation, local elevated calcium concentration neither inhibited oedema
      formation, nor were reduction of inflammatory signs at all observed on the
      microscopical level.

PMID- 1021451
TI  - Comparison of the ototoxic effect of kanamycin on albino and pigmented rats,
      studied using an operant method.
AB  - A study was made of the effect of daily administration of kanamycin (400 mg kg-1)
      on the hearing of Wistar albino and Lister hooded (pigmented) rats, which had
      been conditioned to discriminate an acoustic signal. In all animals except one,
      the drug caused severe, permanent hearing impairment and there was no difference
      between albino and pigmented rats in onset or degree. Other work has suggested a
      mediatory role for melanin pigment in such drug ototoxicity but the significance
      of this must be questioned in view of the failure to find any differences in
      functional deficit.

PMID- 1021452
TI  - Pseudolymphoma of skin induced by oriental hornet (Vespa orientalis) venom.
AB  - Intradermal injection of saline suspension of Vespa orientalis venom sac to 57
      black mice caused a local nodule composed of lymphocytes, few histiocytes and
      plasma cells 10 to 12 days following the injection. This reaction simulates the
      pseudolymphoma reaction observed in humans following arthropode stings.

PMID- 1021453
TI  - [Morphological effects of concanavalin A on amphibian embryonic cells
      differentiating in vitro (author's transl)].
AB  - Concanavalin A exerts an irreversible inhibitory effect on the differentiation of
      cultured embryonic amphibians cells in vitro. Cytological changes and
      distrubances of cell attachment, and spreading to the culture support occur in
      parallel. Polykaryons have been noticed in treated cultures.

PMID- 1021454
TI  - Intracisternal A type particles of the extraocular muscle of hereditary muscular
      dystrophy mouse.
AB  - Intracisternal A type virus (IA) particles were observed in the extraocular
      muscle fiber of hereditary muscular dystroph mouse. The particles appeared
      approximately 65-75 mmu in diameter, with electron lucent cores.

PMID- 1021455
TI  - Cilia in human fetal Schwann cells.

PMID- 1021456
TI  - Cell proliferation in the bone marrow and thymus following partial bone marrow
      aspiration.

PMID- 1021457
TI  - A transmission and scanning electron microsope study of primary neural induction.
AB  - Normal primary neural induction has been further studied by TEM and SEM. A single
      mesoderm cell is usually in contact with several ectoderm cells. The mesoderm
      cells are also contacting other mesoderm cells. It is suggested that ectoderm
      cells are induced in groups and that induction is synchronized by these contacts.
      At the points of contact between mesoderm and ectoderm cells cytoplasmic changes
      are present in the induced tissue.

PMID- 1021458
TI  - Nephrocompensatory growth following thymectomy.
AB  - Thymectomy performed 28 days before unilateral nephrectomy produced significant
      inhibition in compensatory renal growth (CRG) in 3-6-month-old rats. Sera from
      thymectomized animals are not deprived of their renotrophic activity, but
      thymectomy of serum recipients almost abolished the capability of renotrophic
      serum to produce CRG.

PMID- 1021459
TI  - In vitro culture of larval amphibian erythroblasts.
AB  - A larval erythroblast culture method is described. By this method, it is possible
      to cultivate for several weeks a homogeneous population of cells (5-10(5)
      cells/ml medium on average after 4 or 5 days of culture), which are relatively
      synchronous with regard to their state of differentiation.

PMID- 1021460
TI  - Alternative complement pathway: activity levels in allogeneic pregnancy.
AB  - Classical and alternative complement pathway activities have been evaluated in
      sera of women in progressive stages of gestation and in pregnant mice belonging
      to outbred or inbred matings, as compared to suitable controls. While classical C
      pathway was found to be unmodified, the alternative one attained in pregnancy
      significantly higher activity levels. Results are discussed in the light of
      mother-conceptus relationships.

PMID- 1021461
TI  - Mast cells in the pinna of Balb/c 'nude' (nu/nu) and heterozygotes (ny/+)mice.
AB  - The relative number of mast cells in the ear lobes' skin (pinna) of nude
      (athymic) nu/nu and normal (thymic) nu/+ heterozygotes of Balb/c mice was
      similar. The results obtained contradict some suggestions about the general
      influence of the thymus on the number of mast cells in the skin and suggest the
      existence of some local factor(s) in regulation of skin mast cell numbers.

PMID- 1021462
TI  - Serum immunoconglutinins and complement in systemic lupus erythematosus.

PMID- 1021463
TI  - Lack of platelet factor-3 activation after incubation of platelet-rich plasma
      with kaolin in the rat.
AB  - Stypven times, measured in rat platelet-rich plasma (P.R.P.) after incubation
      with kaolin, did not shorten as incubation proceeded, thus reflecting the lack of
      development of platelet factor-3 (PF3) availability in this test system. Repeated
      freezing and thawing of P.R.P. or aggregation with collegan did result in PF-3
      availability. Aggregation and PF-3 availability were inhibited by the compound
      VK774. These findings add another aspect to the list of species differences in
      platelet function.

PMID- 1021464
TI  - Serum and bile modifications in the guinea-pig following chronic treatment with
      PGE1 and PGE2.
AB  - PGE1 increases cholesterolemia without lipemia modifications. In bile there are
      not modifications in cholesterol levels and total lipids appear diminished. PGE2
      raise the lipemia and have no effect in cholesterolemia, moreover bile
      cholesterol and total lipids exhibit no changes. Both PGE1 and PGE2 decreased the
      bile volume.

PMID- 1021465
TI  - Conversion of testosterone to androstenedione by liver homogenates of testicular
      feminized mice.

PMID- 1021466
TI  - In vitro effect of dexamethasone in conversion of 4-14C progesterone in the fetal
      rat adrenal glands.

PMID- 1021467
TI  - RNA biosynthesis in isolated prothoracic glands of Tenebrio molitor in vitro.

PMID- 1021468
TI  - Ovarian LDH activity in gonadotropin-treated immature rats.
AB  - Lactate dehydrogenase (LDH) activity was studied in the ovaries of immature rats
      treated with pregnant mare serum gonadotropin (PMS). LDH activity increased
      sharply at 36 h after PMS injection in the ovarian tissue as well as in the
      blood. It was suggested that the increase of LDH activity in the ovary may be
      related to its increasing ability to secrete estrogen.

PMID- 1021469
TI  - The micro-focal x-ray unit and its application to bio-medical research.
AB  - The micro-focal X-ray unit is a modified Cosslett and Nixon X-ray microscope of
      greater operational stability and flexibility. Its combination with a closed
      circuit television system provides a quick method of obtaining a point source of
      X-rays to examine the detailed structure of organs and biological specimens.

PMID- 1021470
TI  - An inexpensive cuvet for spectrophotometry of samples in 5 mul volumes.

PMID- 1021471
TI  - Directional non-uniformity of pulsatile intramyocardial pressure.
AB  - A method using piezoelectric ceramics was newly devised which permitted
      measurements of intramyocardial pressure. In open-chest dogs, a directional non
      uniformity of the intramyocardial pressure was observed, which may be
      attributable to the variation in the myocardial fibre orientation.

PMID- 1021472
TI  - A heated stage and tissue culture chamber for electrophysiology.
AB  - A simple, inexpensive heating circuit is described for use with a warmed
      microscope stage, small tissue bath, and heated tissue culture chamber. A major
      consideration in the design of the apparatus is a compatability with
      electrophysiological studies. Thus, proper shielding and low profile for
      microelectrode positioning are featured.

PMID- 1021473
TI  - [Clinico-histological picture-review--keratoses].

PMID- 1021474
TI  - [Generalized circumscribed scleroderma and phenylketonuric metabolic changes in a
      girl whose mother was irradiated because of abdominal carcinoma].

PMID- 1021475
TI  - [Experimental skin depigmentation. I. Experimental and clinical experiences].

PMID- 1021476
TI  - [Experimental skin depigmentation. II. Epidermal reaction in external
      administration of depigmenting substances].

PMID- 1021477
TI  - [Comparative studies on the skin of guinea pigs, swine and man following the
      effect of various external agents].

PMID- 1021478
TI  - Haematuria and haemoglobinuria in induced septic abortions. (Report of 3 cases).

PMID- 1021479
TI  - Septic abortion--three year study 1971-1973. Hazards of septic abortion as
      compared to medical termination of pregnancy at Government Erskine Hospital,
      Madurai.

PMID- 1021480
TI  - Abortion and renal failure.

PMID- 1021481
TI  - Impact of abortion hazards on Family Planning Programme.

PMID- 1021482
TI  - Serum FSH, LH (HCG) and prolactin levels during and after labour.

PMID- 1021483
TI  - Effect of proluton depot on postpartum milk secretion.

PMID- 1021484
TI  - Role of emergency hysterectomy in obstetrics.

PMID- 1021485
TI  - Prolapse of the uterus complicating labour (A study of 38 cases).

PMID- 1021486
TI  - Compound presentation and their management.

PMID- 1021487
TI  - Maternal haemoglobin and fetal birth weight.

PMID- 1021488
TI  - Comparative evaluation of urinary oestriol in normal and abnormal pregnancy in
      low socioeconomic classes.

PMID- 1021489
TI  - Calmpose in labour.

PMID- 1021490
TI  - Obstetric behaviour in teenagers. (a study of 1138 consecutive cases).

PMID- 1021491
TI  - Artificial insemination.

PMID- 1021492
TI  - An optimal contraceptive pill. (A clinical study).

PMID- 1021493
TI  - Fertility status following extrauterine gestation.

PMID- 1021494
TI  - Effect of Placentrex on tubal blockage and menstrual irregularities.

PMID- 1021495
TI  - Failures following tubal sterilisation.

PMID- 1021496
TI  - Placenta diffusa percreta.

PMID- 1021497
TI  - Abdominal pregnancy - (3 Case reports).

PMID- 1021498
TI  - A rare complication of twin pregnancy: impaction of twins. (Case report).

PMID- 1021499
TI  - An interesting case of unilateral fused kidneys with haematometra.

PMID- 1021500
TI  - Precocious puberty.

PMID- 1021501
TI  - Hydrosalpinx following tubal ligation.

PMID- 1021502
TI  - Testicular feminization syndrome.

PMID- 1021503
TI  - Degenerating cervical myoma simulating chronic puerperal inversion and gangrene
      of uterus - (Report of a case).

PMID- 1021504
TI  - Central rupture of perineum. (A case report).

PMID- 1021505
TI  - Lung carcinomas induced by oral administration of N-bis(2
      hydroxypropyl)nitrosamine in rats.
AB  - The oral administration of N-bis(2-hydroxypropyl)nitrosamine (DHPN) in drinking
      water induced lung tumors in high incidence in rats at 25 weeks. Histologically,
      they were adenoma, adenocarcinoma, squamous cell carcinoma, and combined squamous
      cell and adenocarcinoma. Metastases of adenocarcinoma were observed in regional
      lymph nodes. The development of tumors in other sites was seen in the liver,
      thyroid, kidney, ureter, urinary bladder, and pancreas. The incidence of lung
      tumor was distinctly higher than that of other sites. These results indicate that
      the target organ of DHPN was the lung and that oral administration of this
      chemical carcinogen was responsible for the development of lung carcinomas in
      rats.

PMID- 1021506
TI  - Mouse strain differences in macrophage activation and anti-tumor activity induced
      by Propionibacterium acnes (anaerobic coryneforms).
AB  - Effect of Propionibacterium acnes on macrophage activation and antitumor activity
      was examined in ddN and SL mice. (1) Carbon clearance was enhanced to the same
      extent by P. acnes  treatment in both strains. (2) Number of peritoneal
      macrophages increased to the same extent by P. acnes treatment in both strains.
      (3) Adhesiveness of peritoneal macrophages, as demonstrated by inhibition or
      migration or an increase in spreading cells, was enhanced more efficiently in ddN
      than in SL mice P. acnes treatment. (4) Mice of both strains died in a similar
      patterns, when they were not pretreated in any way. The treatment with P. acnes
      conferred antitumor activity of a higher degree in ddN than in SL mice. (5)
      Peritoneal macrophages of ddN mice treated with P. acnes exhibited an antitumor
      activity in in vivo neutralization test. These results suggest that strain
      difference in augmentation of antitumor activity by P. acnes is ascribed to
      distinct sensitivity of macrophage functions to a stimulative effect of P. acnes
      in the mouse strains.

PMID- 1021507
TI  - Comparative studies on the antitumor effect on intravenous administration of
      carbazilquinone and mitomycin-C.
AB  - Comparison between Carbazilquinone and Mitomycin-C, both of which contain
      aziridinyl, carbamoyloxy, and quinonyl groups, was made for their therapeutic
      effect upon intravenous administration. Although both agents exhibited a
      significant effect on plasmacytoma X5563 in C3H/He mice to a similar extent,
      Mitomycin-C was not as effective on lympholeukemia L-1210 and on the lung
      metastasis of Ehrlich carcinoma in (C57BL/6 X DBA/2)F1 (BDF1) mice as was
      Carbazilquinone. Possible interpretations regarding this discrepancy are
      discussed.

PMID- 1021508
TI  - Biochemical study of pyloric metaplasia in the mucosa regenerating over
      iodoacetamide-induced fundic ulcers in rat stomach.
AB  - The molecular species and content of pepsinogen in regenerated mucosa over fundic
      ulcers induced in a rat stomach by iodoacetamide were found to be the same as
      those in normal pyloric mucosa, but different from those in normal fundic mucosa.

PMID- 1021509
TI  - Damage and repair of rat liver DNA by simultaneous oral administration of amines
      and nitrite.
AB  - The effect of simultaneous oral administration of dimethylamine or aminopyrine
      and sodium nitrite on the damage and repair of rat liver DNA was studied by the
      use of centrifugation in alkaline sucrose gradient. Fragmentation of the intact
      DNA was observed significantly shortly after combined treatment with aminopyrine
      and nitrite when no liver necrosis occurred yet and the damaged DNA at the lower
      dosage level of aminopyrine with nitrite was found to be repaired in contrast to
      the increased activity of serum aminotransferase. The lowest effective dose on
      DNA damage at 2 hr after administration was about 40 mg/kg of aminopyrine and 80
      mg/kg of sodium nitrite. This effect was equal to that caused by single oral
      administration of 2 to 10 mg/kg of dimethylnitrosamine, while dimethylamine at
      160 or 320 mg/kg together with 80 mg/kg of sodium nitrite produced no pronounced
      DNA damage. The significant damage of rat liver DNA by aminopyrine and nitrite
      correlates well with the easier nitrosation of aminopyrine and the occurrence of
      high incidence of malignant liver tumors in rats fed aminopyrine together with
      nitrite already reported by Lijinsky.

PMID- 1021510
TI  - Effect of 4-hydroxypyrazolo[3,4-d]pyrimidine (allopurinol) administration of
      growth of Ehrlich tumor cells.
AB  - Effect of the administration of 4-hydroxypyrazolo([3,4-d]pyrimidine (allopurinol)
      on the growth of Ehrlich ascites tumor cells was investigated in an in vivo
      system. Oral administration of allopurinol (0.1% in diet) suppressed the growth
      of both ascites and solid types of the tumor after the implantation of Ehrlich
      tumor cells in mice. The inhibitory action depended on the dose but was lost
      repidly when the administration was interrupted. Possible mechanisms involved in
      the inhibitory effect of allopurinol on tumor growth were briefly discussed.

PMID- 1021511
TI  - Growth of mammary tumors in a high and a low mammary tumor strains of mice
      established from the same basal stock of Swiss albino.
AB  - The growth of spontaneous mammary tumors and of tumors transplanted into the
      animals with different hormonal conditions was compared between SHN and SLN
      strains of female mice established from the same basal stock of Swiss albino as a
      high and a low mammary tumor strains, respectively. There were little differences
      between strains in the growth of spontaneous mammary tumors of multiparous mice
      which appeared first. The growth of transplanted mammary tumors was not affected
      by the hormonal conditions of the hosts in either strains. However, the tumors
      became palpable one week after transplantation in SHN, which was 2 weeks earlier
      than in SLN. These findings indicate that the selection of animals for mammary
      tumorigenesis is effective on the time and frequency of malignant transformation
      of mammary cells and on the ""take'' of transplanted tumor cells, but not on the
      growth potentiality of already established tumors. They further suggest autonomy
      in the growth of mammary tumors in both strains of mice.

PMID- 1021512
TI  - Macroscopic demonstration of the distribution of intestinal metaplasia by leucine
      aminopeptidase activity.

PMID- 1021513
TI  - Examination of antitumor activities of platinum complexes of 1,2
      diaminocyclohexane isomers and their related complexes.

PMID- 1021514
TI  - In vitro assay of catalase-depressing activity of toxohormone in cultured liver
      cells.

PMID- 1021515
TI  - [Altitude adaptation. V. (conclusion). Morbidity and mortality. Literature].
AB  - The ability to adapt to extreme conditions is a continously working principle of
      man's evolution, in a permanent orientation to an optimal equilibrium between man
      and environment. A paradigm of biological adaptation is the condition of hypoxia
      at high altitudes, as one of the few environment constellations to which a pure
      biological and thus genetically based answer could be possible. The majority of
      adaptations are influenced by technological actions, which partially modify the
      environment in compensating unfavourable constellations (heating, clothing,
      housing, etc.). It is discussed, how far the adaptation to high altitudes
      produces transitory or permanent alterations with reference to constitution,
      perseverance, cold-sensitivity, diseases, duration of life, fertility, course of
      pregnancy, adaptations at the organ- and tissue-level, blood-composition, fluid
      equilibrium of the body etc., which guarantee the survival of the individual and
      its successful reproduction with regard to the continuance of a mendel
      population. The elucidation of the question on genetic determination of features
      characteristic for high altitude inhabitants is difficult because we know next to
      nothing about the genetic determination of physiologic parameters. Studies on
      ethnic marker-genes (Ethiopia, South-America) give no reference to population
      differences. Remarkable is a striking prevalence of the blood-group O for all
      populations of high altitudes, but one must consider the effects of isolation in
      terms of the increase in the homozygote recessive alleles. We can propose, that
      in the primary settlement at high altitudes a "hard selection" was working, a
      kind of biological assortation-process from the beginning, which eliminated those
      individuals, who proved to be (for genetic reasons?) not adaptable. A good
      example for this are observations of cattle, from which 50% do not develop
      pulmonary hypertension when exposed to altitude, that means they already have a
      higher initial fitness. The non-adaptable animals have to be returned to the
      lowlands. In the F1-generation only 2% of the animals remaining at high altitude,
      develop "brisket disease". Possibly that means a sort of "out-mendeling" of
      "pulmonary-hypertension-genes", which may manifest themselves in the condition of
      hypoxia. Also the good adaptation of llamas is partially due to the fact that the
      camelids per se possess an outstanding O2 affinity and morphologically different
      red blood cells, which predispose this species to inhabit high altitudes.
      Parallel to considerations like these it could be imaginable, that e.g. the
      indianids of mongoloids in general, are genetically composed as fit to inhabit
      lowlands as well as highlands, in contrast to caucasoids and negroids. The
      largest mountain areas of the world (the Andes: 12 X 10(6)), the Himalayas 12 X
      10(6)) are inhabited by populations of mongoloid ancestry, for about 10,000
      years, a period, which ought to be long enough to make possible genetic
      specialisation, although it is not yet possible to prove it...

PMID- 1021516
TI  - [Detection of major genes for quantitative morphologic characteristics on family
      material, sib pairs and parent-child pairs, using as an example head length in
      man].
AB  - The detection of major genes affecting quantitative morphological characters from
      data of families, sib-pairs and parent-child pairs (with the example of head
      length in man). The major genes of human head length are defined utilizing three
      different combinatorical methods of maximum likelihood estimation. To prove the
      discriminatory power of methods, it is necessary in further research to work with
      empirical or simulated sets of multivariate data of which the genetical structure
      is known.

PMID- 1021517
TI  - [The so-called pressure zone of the cerebellum].
AB  - Systematic studies on the so-called cone of basal parts of the cerebellum
      employing a scale of either qualitative and quantitative intensity revealed the
      following: A cone extension of basal cerebellum parts is to be observed in 80.9%
      of random post-morten examination cases with insignificant differences in sex.
      Cerebellum cone frequency amounts to 12.8% in babies, up to 66.7% in infants from
      1 to 14 years of age, and to 91.8% in persons above 15 years of age. Cones are
      not found in foetusses. Cones are almost exclusively formed with the
      participation of those cerebellum parts adjacent to the tonsils, so that the
      termin "tonsil cone" is incorrect. Cerebellum cones can be distinguished by
      various degrees in size. The 1st degree corresponds to a cone height of 5 mm, 2nd
      degree between 5 and 10 mm, and 3rd degree to 10 mm and above. Statistical
      analysis shows that the cone height follows normal distribution, the mean value
      of height being 4.8 mm. No correlation has been found between the cone height and
      clinically detected state of cerebral pressure as well as between space requiring
      processes during the post-mortem examination. Hence the term "pressure cone" is
      wrong. There is a positive correlation between cone formation and other so-called
      morphological symptoms of cerebral pressure. But it is doubtful, whether these
      symptoms may be regarded as a result of pressure on the brain. The occurrence of
      a cerebellum basal sphere cone is considered a normal filling up process of any
      internal space in the skull during brain acceleration. It is only in exceptional
      cases of cone sizes 10 mm and more, that cone formation is significant for the
      diagnosis of a possible increase in cerebral volume. Considering the obviously
      minimal significance of basal cerebellum cone in diagnosing an increase in
      cerebral volume, the following is a suggestion to prove a condition of cerebral
      pressure by means of complementary space determination of the skull.

PMID- 1021518
TI  - [Development of the skeleton in the sheep and the goat. IV. Osteogenesis of the
      cranium].
AB  - 1. The osteogenesis of the cranium was studied on a precisely dated embryological
      and postnatal material from merino-sheep and goats (crossbreed). 2. The order and
      duration of the appearance of ossification centers were determined (see Fig. 6).
      3. It was noticed that, in small ruminants, the beginning of cranial ossification
      indifferent to other parts of the skeleton is not staged in time. Sexual
      dimorphism was only manifested by larger proportions of the male fetuses. An
      exception was noted only in os interparietale, which in male fetuses appeared 4
      to 5 days later in male fetuses. 4. The cranial bones of small ruminants, showed
      a high degree of ossification at birth.

PMID- 1021519
TI  - The behaviour of acetylcholinesterase activity in neurons of the bulbous part of
      the reticular formation in albino rats after bilateral vagotomy.
AB  - The influence of a bilateral vagotomy on the acetylcholinesterase activity (AChE)
      in the neurons of the bulbous part of the reticular formation of albino rats was
      investigated. An increase in the reaction to acetylcholinesterase (AChE) was
      ascertained in the large as well as the small neurons 8 h after the transection
      of the vagus nerves, which indicates their decreased activity. It may be assumed
      that a bilateral vagotomy causes a decrease in the activity of cholinergic
      mechanisms within the periphery of the reticular formation neurons.

PMID- 1021520
TI  - The adequacy of census data in planning and advocacy for the elderly.

PMID- 1021521
TI  - Estimating the local need for elderly congregate housing.

PMID- 1021522
TI  - Barrier-free environments for older americans.

PMID- 1021523
TI  - The planning and implementation of a night emergency service for elderly living
      in congregate housing.

PMID- 1021524
TI  - Two models of geriatric day care; findings from a comparative study.

PMID- 1021525
TI  - Independence training in nursing-home residents.

PMID- 1021526
TI  - Senior esteem as a factor of socioeconomic complexity.

PMID- 1021527
TI  - Patterns of leisure and adjustment to retirement.

PMID- 1021528
TI  - Clinical training and legal services for older people: the role of the law
      schools.

PMID- 1021529
TI  - The professional status of gerontology.

PMID- 1021531
TI  - Good Times.

PMID- 1021530
TI  - Social security: individual or social equity?

PMID- 1021532
TI  - Stamps and the students of aging.

PMID- 1021533
TI  - Vision and mental function of the elderly.

PMID- 1021534
TI  - An outcome evaluation of reality orientation therapy with geriatric patients in a
      state mental hospital.

PMID- 1021535
TI  - The relationship of scientific objectives to population selection and attrition
      in longitudinal studies. The case of the normative aging study.

PMID- 1021536
TI  - Geriatric day care: a family perspective.

PMID- 1021537
TI  - Support groups for elderly persons in the community.

PMID- 1021538
TI  - Community services for the aged: the view from eight countries.

PMID- 1021539
TI  - Planning for income adequacy in retirement: the expectations of current workers.

PMID- 1021540
TI  - Care of the aged: attitudes of white ethnic families.

PMID- 1021541
TI  - Humanistic instructional strategies and retirement education programming.

PMID- 1021542
TI  - Monoamine oxidase activity in blood platelets in alcoholism.
AB  - A newly developed assay for monoamine oxidase (MAO) activity in blood platelets
      was applied in 50 alcoholic patients. The assay is the direct measurement of
      serotonin oxidation by MAO employing a double microcolumn technique on Sephadex G
      10 and Amberlite CG-50 for separating 5-HIAA formed, which is measured
      fluorimetrically. Rebound of MAO activity levels after withdrawal of alcohol was
      observed to be more pronounced in the patients with delirium tremens than those
      who exhibited no outstanding abstinent symptomatology. MAO activity levels
      measured in the 1st week of alcohol withdrawal were 3.49 +/- 1.15 (Mean +/- S.D)
      nmol/mg protein/hour in the alcoholic patients with delirium tremens, a value
      significantly lower than that in the subjects without (p less than 0.01) and that
      in the male normal subjects (p less than 0.001). Four weeks after withdrawal of
      alcohol, the reduced MAO activity levels in the alcoholic population were
      restored to normal levels. These data demonstrate that physical dependency for
      alcohol occurred evidently in the alcoholic patients examined. Delirium tremens
      and other psychotic symptoms in alcoholism may be manifested as impaired
      serotonin metabolism in the brain, which may be due to MAO inhibition caused by
      excessive alcohol intake.

PMID- 1021543
TI  - Reduction of blood platelet serotonin levels in manic and depressed patients.
AB  - Blood platelet serotonin levels were measured in unmedicated 12 manic and 74
      depressive patients with 118 normal control subjects employed. Blood platelets
      were separated by multiple centrifugation in the medium of Na2-EDTA solution, and
      the loss of serotonin during collecting procedures was about 11%. The mean value
      of blood platelet serotonin levels in depressed patients was 594 +/- 288 ng/mg
      platelet protein (+/- S.D.), which was significantly lower than that for normal
      controls, 780 +/- 253 ng/mg protein (p less than 0.001). Age does not account for
      the reduction of serotonin levels both in depressed and in normal population.
      Unipolar and involutional depressed patients exhibited to have the most
      pronounced reduced levels of serotonin of various subtypes of depression, while
      bipolar depressed patients, neurotic and chronic characterological depressed
      patients as well as patients with first-episode depression had the values which
      were comparable with those in normal controls. Manic patients did not show
      enhancement but did reduction of serotonin levels, the mean being 580 +/- 152
      ng/mg protein, which made a contrast with their clinical manifestations of
      exhilaration and hyperactivity. Changes in blood platelet serotonin levels were
      determined before, during and after administration of L-5-HTP with a maintenance
      dose of 300 mg daily in nine depressed patients. Serotonin levels in all subjects
      were lifted to normal levels during the L-5-HTP treatment, while clinical
      symptoms were not improved with the treatment. Reduction of blood platelet
      serotonin levels in depressed patients may be due to their psychobiological
      distinction, which involves abnormal biogenic amine metabolism in the brain.

PMID- 1021544
TI  - A biofeedback study of postural sway.
AB  - An experiment was performed to control postural sway under auditory and visual
      feedback signals using a new apparatus. The subjects of 52 healthy high school
      girls were divided into 13 small groups. Each small group had four subjects who
      were assigned to one of the following four groups; 1) visual feedback group, 2)
      auditory feedback group, 3) auditory and visual feedback group, and 4) control
      group. Comparisons were made as to the duration of the green lamp being on, which
      indicated sway stayed around the initial central gravity. The results showed that
      auditory and visual feedback groups had a significant increase in the duration as
      compared to other three groups. With regard to the changes in the areas of
      postural sway, the largest increase was seen in the auditory and visual group.
      While the three feedback groups showed downward curves, the control group showed
      an upward one. Thus it is suggested that postural sway can be voluntarily
      controlled by a combination of an auditory feedback procedure and a visual
      feedback procedure, but not by either of them independently.

PMID- 1021545
TI  - Hypokalemic myopathy due to chronic alcoholism.
AB  - A patient with hypokalemic myopathy occurring in the context of chronic
      alcoholism was reported. A 56-year-old male patient, heavy drinker for 20 years,
      complained of marked weakness and acutely developing pains in his limbs. The
      principal clinical findings were weakness and tenderness of the proximal limbs
      and girdle muscle. He was unable to lift his head or any extremities from the
      bed. Deep tendon reflexes were diminished, but not absent. There was no sensory
      disturbance except for muscle tenderness. These clinical manifestations
      disappeared gradually by abstinence from drinking, and potassium administration
      therapy, and the patient recovered completely on the 26th day after onset. On the
      day after admission (8th day), serum potassium value was 2.2 mEq/L, and serum CPK
      activity was 4270 IU. The ECG pattern was consistent with a diagnosis of low
      potassium content in serum, and the EMG pattern was consistent with a diagnosis
      of myopathy. These electrophysiological findings had a tendency to recover from
      this pattern to normal range correspondingly with clinical improvement. The
      repeated muscle biopsies showed that vacuolation, hyaline degeneration and
      significant phagocyte infiltration were observed in the muscle on the 9th day
      after the onset of muscle weakness, and that these pathological findings
      disappeared almost completely three weeks later. The frequently repeated
      examinations of potassium content and CPK activity in sera showed that there was
      a close correlation between these biochemical abnormalities and clinical
      improvement. The pathogenesis of alcoholic myopathy and significance of CPK
      abnormality in chronic alcoholism were discussed.

PMID- 1021546
TI  - Effects of electrical stimulation of the substantia nigra on responses of the
      lateral geniculate body neurons to light.
AB  - Effects of electrical stimulation of the substantia nigra on responses of the
      lateral geniculate neurons to light were studied. Responses of the neurons to
      flash were enhanced or inhibited by conditioning stimulation of the substantia
      nigra. Enhancement of firing by nigral stimulation more often occurred in neurons
      excited primarily by flash, but inhibition was more commonly observed in those
      which showed a primary neuronal silence after light.

PMID- 1021547
TI  - Effects of psychotropic drugs upon the hypothalamic rage response in cats.
AB  - Effects of Chlorpromazine (CPZ), Haloperidol (HLP), Pentobarbital (PTB), and
      Diazepam (DZP) upon thresholds of the hypothalamically elicited rage response,
      i.e., directed attack and treat responses, were studied in chronic cats. All
      these drugs elevated the directed attack thresholds. CPZ and HLP elevated also
      the threat response thresholds and produced ataxia, but DZP did not show these
      effects. From these results, it is suggested that CPA and HLP suppressed the
      amygdalo-ventromedial hypothalamic nuclear and cerebellar functions and DZP
      suppressed the afferent pathway of the direct attack. PTB showed intermediate
      effects between the above two groups.

PMID- 1021548
TI  - Sexual and parasexual approaches to the genetic analysis of the laboratory mouse,
      Mus musculus.
AB  - The mouse genetic map has been characterized largely through breeding studies
      based on the principles of Mendelian genetics. More recently, specific genetic
      information has been obtained from somatic cell studies using the techniques of
      in situ hybridization and somatic cell hybridization. The genetic analysis
      possible through these sexual and parasexual approaches is described, and
      specific linkage information from recent somatic cell studies is reviewed.

PMID- 1021549
TI  - Somatic hybridization in higher plants.
AB  - Somatic hybridization in higher plants has come into focus since methods have
      been established for protoplast fusion and uptake of foreign DNA and organelles
      by protoplasts. Polyethylene glycol (PEG) was an effective agent for inducing
      fusion. Treatment of protoplasts with PEG resulted in 5 to 30% heterospecific
      fusion products. Protoplasts of different species, genera and even families were
      compatible when fused. A number of protoplast combinations (soybean + corn,
      soybean + pea, soybean + tobacco, carrot + barley, etc.) provided fusion products
      which underwent cell division and callus formation. Fusion products initially
      were heterokaryocytes. In dividing heterokaryocytes, random distribution of
      mitotic nuclei was observed to be accompanied by multiple wall formation and to
      result in chimeral callus. Juxtaposition of mitotic nuclei suggested nuclear
      fusion and hybrid formation. Fusion of heterospecific interphase nuclei was
      demonstrated in soybean + pea and carrot + barley heterokaryons. Provided
      parental protoplasts carry suitable markers, the fusion products can be
      recognized. For the isolation and cloning of hybrid cells, fusion experiments
      must be supplemented with a selective system. Complementation of two non-allelic
      genes that prevent or inhibit growth under special culture conditions appears as
      the principle on which to base the selection of somatic hybrids. As protoplasts
      of some species have been induced to regenerate entire plants, the development of
      hybrid plants from protoplast fusion products is feasible and has already been
      demonstrated for tobacco.

PMID- 1021550
TI  - Characteristics of solgel scintillators for liquid scintillation counting of
      aqueous and non-aqueous samples.

PMID- 1021551
TI  - Chemical and biological studies on 99mTc-DMS--II: Effect of Sn(II) on the
      formation of various Tc-DMS complexes.

PMID- 1021552
TI  - A criterion for classifying radioactive cells.

PMID- 1021553
TI  - Projected numbers of health physicists, 1975-2000.

PMID- 1021554
TI  - Radiochemical determination of 89Sr and 90Sr: a comparison of methods based on
      error analysis.

PMID- 1021555
TI  - Photostimulated thermoluminescence of lithium fluoride as an ultraviolet
      radiation dosimeter.

PMID- 1021556
TI  - Predicted and measured exposures from 41Ar released to the atmosphere by a heavy
      water research reactor.

PMID- 1021557
TI  - An investigation of occupational exposure of Taiwan (1973-1975).

PMID- 1021558
TI  - The chemical form of americium and curium in urine.

PMID- 1021559
TI  - Thermoluminescence of Mgo single crystals for u.v. dosimetry.

PMID- 1021560
TI  - Biological half-life of a 95mtechnetium labeled bone imaging agent.

PMID- 1021561
TI  - Radiation exposure during air and ground transportation.

PMID- 1021562
TI  - Handling technique for thermoluminescent dosimeters.

PMID- 1021563
TI  - "Half-life" terminology for 137Cs in humans.

PMID- 1021564
TI  - Study of erythrocyte glucose-6-phosphate dehydrogenase and abnormal haemoglobins
      in an endogamous community--"Katkaris"--a survey.

PMID- 1021565
TI  - Haemostasis in hepatic disorders.

PMID- 1021566
TI  - Intraluminal manometry in evaluation of esophageal disease.

PMID- 1021567
TI  - Renal amyloidosis.

PMID- 1021568
TI  - Cerebrospinal fluid lactic dehydrogenase activity in various neurological
      disorders.

PMID- 1021569
TI  - Amyloid--an unfolding enigma.

PMID- 1021570
TI  - Congenital familial non-hemolytic hyperbilirubinaemia.

PMID- 1021571
TI  - Renal hydatid cyst presenting with hypertension.

PMID- 1021572
TI  - A study of metabolic bone disorder in cirrhosis liver.

PMID- 1021573
TI  - [Kinetics of survival patterns and experimental determination of senescence
      rate].

PMID- 1021574
TI  - [Microcalorimetric studies of the transformation of fibrinogen into fibrin
      catalyzed by thrombin].

PMID- 1021575
TI  - [Comparison of the processes of growth and transformation during 3-methylpyridine
      conversion by Nocardia cultures].

PMID- 1021576
TI  - [Effect of hydrocortisone on bone marrow hematopoietic stem elements of mouse
      (CBAXC57BL)F1-hybrids].

PMID- 1021577
TI  - Research in orthokeratology. Part I: Introduction and background.

PMID- 1021578
TI  - Prescribing for performance and prevention.

PMID- 1021579
TI  - The stimuli to accommodation in the optometric examination.
AB  - The study of the stimuli to accommodation has been a topic of particular interest
      to vision scientists for the past 40 years. Currently, as revealed by a review of
      the literature, there are 11 different stimuli to accommodation. While it is
      difficult enough to hold 10 stimuli constant to measure the effect of a single
      stimulus, stimulus control becomes an even bigger problem when we consider
      stimulus interactions. With 11 different stimuli there are 2,047 possible
      stimulus combinations. In the present paper, the authors discuss at length the
      relationship between stimulus control problems and clinical optometric routine.

PMID- 1021580
TI  - Why the career OD in the army is biting the bullet today.

PMID- 1021581
TI  - Optometry as a primary health entry point.

PMID- 1021582
TI  - Prescribing simple low vision aids--a case report.

PMID- 1021583
TI  - The interpretation of systemic arterial blood pressure. Part I: Glaucoma,
      papilledema and pharmacology.

PMID- 1021584
TI  - Prevalence of undiagnosed eye/vision disorders in a VA hospital.
AB  - A study population of one hundred and one subjects, chosen according to
      recommended epidemiologic procedures to assure an accurate representation of the
      total Birmingham veteran population, were given complete optometric examinations.
      The primary criterion for inclusion in the study was a need for coming to the
      hospital on the interview day for any health problem other than visual or ocular.
      The results of the statistical analysis showed agreement between the Birmingham
      veteran population and the general population with regard to vision and ocular
      disorders. Presbyopia was found to be the most prevalent vision disorder, and
      fifty-four per cent of the study population needed either prescription lenses for
      the first time or a significant change in their present spectacles for maximum
      visual acuity. When this figure is projected nationally, fifty-four percent of
      the fourteen million outpatients treated last year in VA medical care facilities
      would represent 7,616,000 veterans in need of vision care services annually. In
      fact, since the sample average age was 46, and the average age for veterans
      nationally is 55, the figure for those with uncorrected vision defects may be
      even higher.

PMID- 1021585
TI  - An interdisciplinary team approach--a case report.
AB  - A case study is presented as a means of demonstrating the advantage of an
      interdisciplinary approach. The paper familiarizes the reader with the
      contributions to be made by a team composed of an optometrist, speech
      pathologist/audiologist, psychologist, and educational diagnostician. Based on
      the authors' experiences, it would appear that the total team approach is a most
      beneficial way of assisting the child with a learning disability.

PMID- 1021586
TI  - A defense against professional liability? Precision measurement of the corneal
      topography.
AB  - New techniques must be developed if optometry is to be adequately armed against
      malpractice liability--especially in terms of contact lenses. An instrument
      capable of both measuring and recording corneal topography is essential to
      development of the optometrist's first line of defense: Proper instrumentational
      record-keeping.

PMID- 1021587
TI  - Adverse response to prism therapy in strabismus.
AB  - The recent literature on prism therapy in strabismus is reviewed. A case is
      reported in which an esotrope, treated by means of prism neutralization to effect
      sensory orthotropia, responded with a marked increase in the angle of squint.
      Guidelines are suggested to minimize risk of such adverse effect when prism
      therapy is attempted.

PMID- 1021588
TI  - Changes in corneal curvature and refractive error upon refitting with flatter
      hydrophilic contact lenses.
AB  - Eight subjects who wore hydroxy-ethylmethacrylate (HEMA) contact lenses showed a
      steepening in corneal curvature and an increase of minus in their post-wear
      refraction after three months of wear. After one year or more of wear, with the
      previously noted changes still present, these patients were fitted with a flatter
      series lenses which they wore for three months. Significant results are noted in
      corneal curvature and post-wear refractive error.

PMID- 1021589
TI  - Case history: Vision care of Paul, infant-at-risk.

PMID- 1021590
TI  - Unusual pupillary response.

PMID- 1021591
TI  - A classification for congenital limb malformations.
AB  - The classification for congenital limb malformations adopted by the American
      Society for Surgery of the Hand, the International Federation of Societies for
      Surgery of the Hand, and the International Society of Prosthetics and Orthotics
      is presented. This method groups similar patterns of deficiencies according to
      the parts that have been primarily affected by certain embryological failures,
      whether the insult involves a total part (skeletal and soft tissue) or only the
      dermomyofascial structures. The main categories of this classification are (I)
      failure of formation of parts. (II) failure of differentiation (separation) of
      parts, (III) duplication, (IV) overgrowth, (V) undergrowth, (VI) congenital
      constriction band syndrome, and (VII) generalized skeletal abnormalities. The
      rationale and method of use of the classification are discussed. This method has
      been tested and used in a variety of centers and has been found to be properly
      conceived and practical.

PMID- 1021592
TI  - Biochemical genetic variation in populations of golden trout, Salmo aguabonita:
      evidence of the threatened Little Kern River golden trout, S.a. whitei.
AB  - Eight wild populations of the High Sierra golden trout, Salmo aguabonita, and one
      domestic stock of rainbow trout, Salmo gairdneri, were examined for biochemical
      genetic variation in eight protein systems. Variation within the eight systems
      was determined by at least 10 loci in both golden and rainbow trout and all the
      alleles identified in rainbow trout were observed as electro-phoretically
      identical phenotypes in golden trout. Variation was observed at an average of 51
      percent of the loci in the golden trout samples and for five of the 10 loci in
      the rainbow trout. Average heterozygosity ranged from 12.6 to 13.9 percent for
      seven of the golden trout populations with one showing a low value of 5.4
      percent. A comparable estimate of 12.1 percent was found for the rainbow stock.
      On the basis of genetic variation and allele frequencies at three loci, the eight
      golden trout populations were divided into two distinct groups. Three populations
      sampled from the Little Kern River basin tended to be genetically distinct from
      two additional Little Kern River basin populations and from three geographically
      distinct populations sampled from the eastern Kern River area. The former three
      populations were hypothesized to be of a recent rainbow-golden hybrid origin.
      Trout in the other two Little Kern River basin populations, sampled in head
      waters of a stream tributary to the Little Kern River, were considered to be the
      threatened Little Kern golden trout, S. a. whitei Evermann, due to their high
      degree of genetic similarity to the geographically distinct subspecies S. a.
      aguabonita sampled from the eastern Kern River area. The finding of substantial
      genetic variation in the wild golden trout populations indicates that this
      threatened species is not at present genetically impoverished and thus does not
      appear to be in immediate danger of extinction through lack of adaptive
      capability.

PMID- 1021593
TI  - Random determination of a developmental process: reversal of normal visceral
      asymmetry in the mouse.
AB  - Situs inversus viscerum in the mouse has been shown to be inherited as an
      autosomal recessive trait (gene symbol iv) with reduced penetrance. It is
      hypothesized that the normal allele at the iv locus exhibits complete dominance
      and controls normal visceral asymmetry. Absence of this control allows the situs
      of visceral asymmetry to be determined in a random fashion. This hypothesis also
      appears to apply to the inheritance of situs inversus in man and to the
      experimental production of situs inversus.

PMID- 1021594
TI  - Horse, ass, and mule chromosomes.
AB  - Karyotypes of the horse with 64 chromosomes, the ass with 62 chromosomes, and the
      mule with 63 chromosomes are presented. The chromosome complements of each
      species and their mule hybrid are analyzed and compared.

PMID- 1021595
TI  - Mutant allele frequencies among domestic cats in some eastern areas of Canada:
      regional homogeneity of factors in Canadian Atlantic Provinces and the French
      colony of Saint Pierre.
AB  - Surveys to determine mutant allele frequencies in domestic cats of the Canadian
      Atlantic Provinces (Halifax, Nova Scotia; Fredericton, New Brunswick;
      Charlottetown, Prince Edward Island; St. John's Newfoundland) and the French
      colony of Saint Pierre, Saint Pierre et Miquelon, reveal a general regional
      homogeneity for most factors. Despite diverse historical patterns of settlement,
      a strong common component of origin is indicated. This is tentatively identified
      as late 18th and early 19th century British. One mutant, polydactyly, which is of
      New England origin appears to have been distributed largely by loyalist refugees
      from New England at the time of the American Rebellion. No elements of a specific
      Acadian (French) character have yet been identified. Siamese cats have been
      "introduced" to the region in recent years and are now so abundant that they will
      undoubtedly cause a significant change in some mutant allele frequencies over the
      next few decades. Interregional exchanges of cats no doubt are contributing to
      homogenizing the populations of the area, but the practice of sterilization of
      pets offsets this to some degree.

PMID- 1021596
TI  - The genetics of Artemia salina. VII. Reproductive isolation.
AB  - Fifteen of 20 gonochoristic Artemia populations are crossfertile with diploid San
      Francisco shrimps, producing fertile F1 and viable F2 progeny. Partial sex
      linkage of white eye was observed and frequency of crossing over between the
      white and sex loci did not exceed the range of values observed in San Francisco
      shrimps. Possible mechanisms for wide dispersal of this diploid genotype are
      discussed. Five populations are reproductively isolated from San Francisco
      shrimps: Mono Lake, Hidalgo, Lake Urmia, San Bartolomeo, and Tunisia. The last
      two are inter-fertile.

PMID- 1021597
TI  - Linkage of the cadmium resistance locus to loci on mouse chromosome 12.
AB  - The autosomal recessive gene cdm that confers resistance to cadmium-induced
      testicular necrosis in certain inbred strains of mice has been mapped on
      Chromosome 12 near varitint-waddler (Va). A 3-point cross involving Va, cdm, and
      amylase-1 (Amy-1) indicated the following gene order and approximate distances:
      Va-8-cdm-17-Amy-1. The cdm locus is the first polymorphic locus to be placed on
      Chromosome 12.

PMID- 1021598
TI  - A method to predict the probabilities to homozygous recessives and of
      heterozygotes.
AB  - Where the occurrence of homozygous recessives and heterozygotes is known in the
      pedigrees of prospective sires and dams, a method and appropriate tables are
      given to predict the minimum probability 1) that progeny will be homozygous
      recessive, or 2) that progeny of dominant phenotype are heterozygous.

PMID- 1021599
TI  - Aspartate aminotransferase activity and glutamic dehydrogenase in the cerebellar
      cortex in several species of animals. A histochemical study.
AB  - The histochemical study of the consumption of glutamic acid by way of the
      aspartate aminotransferase and the glutamic dehydrogenase in the cerebellar
      cortex of several species of animals have demonstrated that in that nerve centre
      exists some structures in which the mentioned consumption is specially or
      exclusively realized by means of one way and not for other different one. Is
      observed, as well, that in the rats, chicken and lizard, the baskets that
      surround the Purkinje cells are constituted by basket cells axons and by
      recurrent collaterals of Purkinje axons and that those structures have an intense
      aspartate aminotransferase activity, but not glutamic dehydrogenase. The
      aspartate aminotransferase activity was not observed on the other side, in the
      perikarya of the Purkinje cells of the related animals. However, there exists
      intense glutamic dehydrogenase activity. On the other hand, in the toad was not
      observed baskets with aspartate aminotransferase activity but this enzyme was
      presented on the other side in the perikarya of the Purkinje cells. All these
      observations have suggested the possibility that this special utilization of the
      glutamic acid is in some way concerned with the transmission phenomenons of the
      nerve impulse.

PMID- 1021600
TI  - [Electronmicroscopical and morphometrical study of rat hippocampal synapses].
AB  - The neuronal structure and synaptology of the hippocampus of the rat are studied
      using neurohistological, electron microscopical and morphometrical methods. After
      Golgi-impregnations the neurons of the hippocampus were classified by reason of
      special morphological features (pericaryon, dendritic, ramification, course and
      termination of the axons). The neurons of the hippocampus show from the region
      CA4 towards the region CA1 an increasing "pyramidalization" which is explained
      respecting the neuronal structure and synaptic architectonics as the result of a
      specific presynaptic representation of afferents at the neurons. The high degree
      of differentiation of the CA1-pyramids speaks for the progressive developmental
      tendency in the phylogenesis of these pyramids compared to the neocortical
      neurons. The ultrastructural investigations of the hippocampus show that each
      individual layer of the regions CA1, CA3 and CA4 has a characteristic synaptic
      architectonics. In all hippocampal layers the axo-spino-dendritic contacts are
      the most frequent type of synapses with the structural characteristics of the
      excitatory synapses; the synaptic contact appears as "Bouton en passage"
      respectively as "Bouton terminal". The axosomatic synapses of the stratum
      pyramidale (CA1 to CA3) predominantly are developed as symmetrical contacts with
      inhibitory function. As the terminals of the basket cells they represent the
      morphological correlate for the recurrent inhibitation of the pyramids by the
      inhibitory effecting basket cells. In the supra- and infrapyramidal layers of the
      regions CA3 and CA4 special contacts are developed for the connection withe the
      mossy fiber terminals--at the pericarya and the main dendrites as so-called
      somatic and dendritic protrusions and as micro-dendrites. As has been established
      for the neocortex, the dendritic spines are the decisive receptive postsynaptic
      structural characteristic of the hippocampus as well. Pre- and postsynaptic
      elements show a broad scope of variation in forming their structures. This also
      applies to the intrahippocampal systems with their highly complex structure which
      is the morphological expression of an extremely high degree of differentiation.
      The morphometrical investigations of the ultrastructure of synapses enclose the
      calculation of the number of synapses per mm3 of the volume of layers, the
      average individual volume of synapses, the presynaptic portion of volume of the
      relative volume of cortex of the hippocampal layers as well as the average number
      and size of the synaptic vesicles. The average number of synapses per mm3 brain
      tissue runs in CA1 to 5,9 X 10(9), in CA3 to 7,9 X 10(9) andin CA4 to 8,7 X 10(9)
      synapses per mm3. The average individual volume of synapses amounts to 0,2-0,3
      mm3 whereas the average portion of volume of the presynaptic structures per
      relative cortical volume comes to 14% in CA1, 16-19% in CA3 and 15% in CA4.

PMID- 1021601
TI  - Retinotectal system of the tortoise, Testudo horsfieldi, Gray (morpho-functional
      study in the norm and after enucleation).
AB  - The optic nerve and mesencephalic optic centre (tectum opticum, TO) of the
      tortoise, Testudo horsfieldi, Gray, in the norm and after the enucleation have
      been studies using Golgi's method, electron microscopy and the
      electrophysiological technique. The optic nerve comprises about 400,000 fibres
      represented by two classes of axons: myelinated (10%) and unmyelinated (90%). The
      diameters of the former vary within 0.3-3 mum, of the latter within 0.3-1.1 mum.
      The neurogramms of the optic nerve contain two components corresponding to the
      two rates of conduction through different groups of fibres (1.3 musec and 0.5
      musec). The stratified synaptic organization of the TO has been investigated. The
      optic terminals are shown to join in complex synaptic formations at certain
      levels of the upper layers of the TO (Strata I, II and III). The process of
      degeneration in the optic system of Testudo is drastically stretched in time. It
      was demonstrated by the electrophysiological control that the TO potentials
      induced in response to the nerve stimulation were not registered any longer only
      6-6.5 months after the enucleation. Certain groups of retinal fibres of the optic
      nerve and their terminals in the TO are shown to degenerate differently and
      asynchronously. Earlier unknown types of destructive changes of the terminals
      (vesicular, neurofilamentous, glycogen and others) are described. It is suggested
      that the different types of degeneration of the optic fibres and their terminals
      are the result of possible biochemical heterogeneity of the retinal ganglious
      cells. The comparison of the terms and types of degeneration of different groups
      of nervous fibres in the optic nerve and their terminals in the TO has revealed
      some correlations suggesting that the myelinated optic fibres produce nervous
      terminals degenerating by the "dark" type, whereas the unmyelinated optic axons
      may be subdivided into several groups, each producing nervous terminals subjected
      to a definite type of destruction ("clear", "vesicular", "neurofilamentous"
      etc.). The localization of certain groups of therminals at certain levels of the
      cortical plate of the TO confirms the electrophysiological data on the stratified
      organization of the retino-tectal projections in the TO of lower vertebrates. It
      has been shown by the comparison of the results obtained with those reported for
      Emys orbicularis, L. that the two species have marked differences in the morpho
      functional characteristics of the retino-tectal system, neuronic composition of
      the TO, the character of destructive changes of the terminals after the
      enucleation and the component composition of polysynaptic complexes and
      glomerules. Probably these differences may come from the peculiarities of the
      perception and transformation of visual information in the species.

PMID- 1021602
TI  - A simple and sensitive fluorometric assay method for taurine using high-voltage
      paper electrophoresis.
AB  - A simple and sensitive fluorometric assay method for taurine (2
      aminoethanesulfonic acid) has been developed. For the separation of taurine, high
      voltage paper electrophoresis subsequent to column chromatographic procedures was
      employed. Fluorescent product of taurine was yielded by spraying fluorescamine (4
      phenylspiro [furan-2(3H), 1'-phthalan]-3, 3'-dione) and borate buffer on the
      paper, and the fluorescence was assayed spectro-fluorometrically after eluting
      with 50% ethanol. The linear relationship between the concentration of taurine
      and fluorescence developed was achieved over the concentration ranges of 0.5-10
      nmoles, and the recoveries obtained were 90-100%. The specificity of this method
      for taurine was satisfactory and structural analogues involved in the metabolic
      pathway of taurine did not interfere with the assay. Examples for tissue levels
      of taurine in various organs of the rat as determined by this new method are also
      presented.

PMID- 1021603
TI  - Effect of strontium on the epiphyseal cartilage plate of rat tibiae-histological
      and radiographic studies.
AB  - Following dietary administration of strontium carbonate, histological and
      radiographic changes in the epiphyseal cartilage plate of the rat tibiae were
      examined in the present study. The weight gain of the rat fed a strontium diet
      was less than that of the control rats. Longitudinal growth of tibiae and
      endochondral ossification were inhibited by strontium administration. The widths
      of both proximal and distal cartilage plates increased enormously as has also
      been shown by other investigators. Sizes of chondroblasts in columns of proximal
      cartilage plate in rats fed a strontium diet were smaller than those of the
      control rats and were not different between upper and lower parts. It is
      suggested that strontium inhibits bone growth through the inhibitory action on
      the maturation process of chondroblasts and the succeeding endochondral
      ossification.

PMID- 1021604
TI  - Effects of palytoxin on isolated intestinal and vascular smooth muscles.
AB  - Palytoxin (PTX), the most potent marine toxin isolated from the Zoanthid,
      Palythoa tuberculosa, was studied to determine the effect on isolated smooth
      muscles. In guinea pig taenia coli PTX at above 3 X 10(-10) g/ml caused a
      contraction which slowly subsided under isotonic recording. Under isometric
      recording PTX at above 1 X 10(-10) g/ml caused a contraction which depended on
      the spontaneous activity. The PTX-induced contraction was not affected by
      atropine, tripelenmamine or tetrodotoxin but was inhibited by 5 mM Mg,
      norephinrphrine, isoprenaline or papaverine. PTX at above 1 X 10(-9) g/ml induced
      an increase in spike frequency and a slight depolarization accompanied with a
      contraction when measured using a sucrose gap method. In some cases the spike
      generation was almost abolished after a long exposure to higher dose of PTX and
      the developed tension gradually decreased. Under isometric recording PTX caused a
      sustained contraction in rabbit aorta, dog mesenteric and coronary arteries at
      above 1 X 10(-10) and 1 X 10(-11) g/ml, respectively, in a dose-dependent manner.
      The coronary artery was most sensitive among the preparation used. PTX-induced
      contraction in aorta was irreversible, was not influenced by phentolamine but
      diminished with 5 mM Mg and disappeared in a D-600 or Ca-free medium. PTX is thus
      an extremely potent and direct stimulant which acts on smooth muscles.

PMID- 1021605
TI  - Cumulative effects of penfluridol, a long-acting neuroleptic drug, as assayed by
      its behavioral actions.
AB  - Penfluridol, a long-acting neuroleptic drug, was repeatedly given to rats well
      trained on the discriminated avoidance schedule (intertrial interval, 25 sec;
      warning duration, 5 sec), and accumulation of the effects were investigated by
      observing the behavioral changes. When penfluridol was orally given in a dose of
      2-8 mg/kg once daily for 10 consecutive days, the suppression of avoidance
      response was progressively enhanced until the 3rd-4th day. But from the 4th day,
      the maximum level of suppression was maintained during the later medication. On
      its withdrawal, the avoidance response was gradually restored, returning to the
      initial level in 3-4 days. When 8 mg/kg was given at 1-2 weeks after the
      withdrawal, the same suppression was observed as after the single administration
      of the same dose. The progressive enhancement of suppression in the early half of
      the medication period evidently indicated the cumulative effect. The degree of
      suppression during the plateau showed a linear correlation with the dosage, and
      was estimated to be about 3,5 times as high as in the corresponding single
      administration.

PMID- 1021606
TI  - Studies on cyclic nucleotides in the adrenal gland. V. Adenylate cyclase in the
      adrenal medulla.
AB  - Effects of various chemical agents eliciting the catecholamine-release on the
      adenylate cyclase-cyclic AMP generating system have been studied in the secretory
      process of the bovine adrenal medulla slices. Cyclic AMP levels were not affected
      at the interval of the maximal increase of the catecholamine-release by
      acetylcholine, but increased gradually some time after the end of the release/or
      at the beginning of the restoration of catecholamine in the medulla tissue. This
      delayed increase in the medullary cyclic AMP is not attributed to a direct
      involvement in 'stimulus-secretion coupling process' of the medullary secretion,
      but rather may be caused by release of intracellular catecholamine.

PMID- 1021607
TI  - Tissue distribution and characteristics of xanthine oxidase and allopurinol
      oxidizing enzyme.
AB  - Tissue distribution and levels of allopurinol oxidizing enzyme and xanthine
      oxidase with hypoxanthine as a substrate were compared with supernatant fractions
      from various tissues of mice and from liver of mice, rats, guinea pigs and
      rabbits. The allopurinol oxidizing enzyme activities in liver were quite
      different among the species and the sex difference of the enzyme activity only in
      mouse liver. In mice, the highest activity of allopurinol oxidizing enzyme was
      found in the liver with a trace value in lung, but the enzyme activity was not
      detected in brain, small intestine and kidney, while the highest activity of
      xanthine oxidase was detected in small intestine, lung, liver and kidney in that
      sequence. The allopurinol oxidizing enzyme activity in mouse liver supernatant
      fraction did not change after storage at -20 degrees C or dialysis against 0.1 M
      Tris-HCl containing 1.15% KCl, but the activity markedly decreased after dialysis
      against 0.1 M Tris-HCl. On the contrary, the xanthine oxidase was activated 2 to
      3 times the usual activity after storage at -20 degrees C or dialysis of the
      enzyme preparation. These results indicated that allopurinol was hydroxylated to
      oxipurinol mainly by the enzyme which is not identical to xanthine oxidase in
      vivo. A possible role of aldehyde oxidase involved in the allopurinol oxidation
      in liver supernatant fraction was dicussed.

PMID- 1021608
TI  - Rat strain differences in the acquisition of conditioned avoidance responses and
      in the effects of diazepam.
AB  - Adult male albino rats of three strains--Wistar, Sprague-Dawley and Holtzman-
      were trained to press a lever to avoid electric shocks under Sidman-type (R-S
      interval-20 sec; S-S interval=5 sec) and discriminated avoidance (ITI-15 sec;
      warning duration=5 sec) schedules, and the acquisition processes of avoidance
      responses, and the properties of behavioral baselines were investigated. Under
      both schedules, Wistar strain rats, though showing poorer results than the other
      two in the beginning, rapidly progressed with the repetitive training, and
      finally displayed excellent and stable performances. Srague-Dawley strain rats
      were poorer in performances, with delayed acquisition and prolonged warm-up
      effect in the within-session performance. The results of Holtzman strain rats
      ranked between the two. After the establishment of stable behavioral baselines
      under both schedules, 0.5, 1.0 and 2.0 mg/kg of diazepam were given
      subcutaneously, and it was found that in Wistar and Holtzman strain rats, the
      avoidance responses were inhibited together with increase of delivered shocks in
      parallel to the doses. In Sprague-Dawley strain rats, however, the avoidance
      responses were conversely improved with 0.5 and 1.0 mg/kg, while such tended to
      be inhibited with 2.0 mg/kg, with marked concomitant ataxia. As definite strain
      differences in avoidance response were demonstrated herein, selection of the most
      appropriate strain should be made when designing behavioral experiments.

PMID- 1021609
TI  - Irreversible inhibitory effect of atropine on contractile responses to drugs in
      isolated rabbit ileum.
AB  - Effect of atropine sulfate (atropine) on the contractile responses to
      acetylcholine chloride (ACh), potassium chloride (K) and barium chloride (Ba) was
      investigated in isolated rabbit ileum. Tension of the strips suspended in the
      bath medium (Locke solution, 30 degrees C) was isotonically recorded. The K(ED50)
      and Ba(ED50)-induced contractions were not affected by atropine at 3.0 X 10(-4)
      mM, which reversibly abolished the ACh(ED100)-contraction. After washout of 6.0 X
      10(-4) mM atropine, the phasic, but not the tonic, component of ACh(ED50)-,
      K(ED50)- and Ba(ED50)- contractions was to some extent inhibited irreversibly. On
      the contrary, such irreversible inhibition of the phasic component was not
      produced by atropine methylbromide even in the high concentration of 3.0 X 10(-3)
      mM. The irreversible inhibitions by atropine of 6.0 X 10(-4) mM on the phasic
      component of ACh- and K-contractions were protected by pretreatment with a high
      concentration of ACh or K. Further, these irreversible inhibitions by atropine
      were potentiated by the absence of Ca and were abolished by the increase of Ca
      content in bath media. These results suggest that the irreversible inhibition of
      the contractile responses to drugs by atropine in high concentration may be due
      to the interference with the mobilization of Ca in the deep layer of the
      membrane, rather than by a blockade of muscarinic receptor sites.

PMID- 1021610
TI  - Mitigation of caffeine-induced fetopathy in mice by pretreatment with beta
      adrenergic blocking agents.
AB  - In a previous experiment, fetopathic effects of caffeine were significantly
      reduced by pretreatment with propranolol at dosage levels of 2.5 to 10 mg/kg. The
      present experiments were undertaeken to investigate the relation between time
      intervals of propranolol pretreatment and its effect on reducing fetopathy.
      Furthermore, the effect of timolol, another beta-adrenergic blocking agent, on
      reducing fetopathy was compared with that of propranolol. Propranolol (5 mg/kg)
      administered 15, 30 or 60 minutes before caffeine treatment significantly reduced
      the caffeine-induced fetopathy. The optimal effect was found when propranolol was
      given 30 minutes before caffine. The reduction in fetopathy by timolol
      pretreatment was comparable to that of propranolol. The results lend support to
      the hypothesis that the fetopathic effect of caffeine is linked with released
      catecholamines in material or fetal issues of mice.

PMID- 1021611
TI  - Substance P in the central nervous system of rabbits: uptake system differs from
      putative transmitters.

PMID- 1021612
TI  - Protective effect of sodium polyacrylate on induced duodenal ulceration in guinea
      pigs.

PMID- 1021613
TI  - Inhibitory effect of endogenous macromolecule on the Ca++-stimulated
      acetylcholine release from the crude synaptic vesicles.

PMID- 1021614
TI  - Further electrophysiological evidence for the GABA-like effect of droperidol in
      the Purkinje cells of the cat cerebellum.

PMID- 1021615
TI  - Cadmium-induced inhibition of twitches in isolated rat diaphragm.

PMID- 1021616
TI  - [Differential diagnosis of myocardial dystrophy of different etiology developing
      after physical overexertion].
AB  - A total of 46 sportsmen with dystrophy of the myocardium due to chronic physical
      overexertion were subjected to an electrocardiographic examination in conjunction
      with functional tests (orthostatic, physical load tests, potassium chloride and
      inderal tests). The derangement of the repolarization phase on the ECG arising in
      myocardial dystrophy on account of physical overexertion was found to have a
      diverse genesis and can be caused by the development of neurodystrophy, disorders
      in the electrolytes metabolism (substantial losses of potassium) and by
      myodystrophic cardiosclerosis. The available data made it possible to educe
      criteria for differential diagnosis of myocardial dystrophy of diverse genesis
      arising due to physical overexertion.

PMID- 1021617
TI  - [Physical work capacity in rheumatic heart defects in children].
AB  - Physical performance of children with rheumatic heart diseases depends upon the
      activity of rheumatism (rheumatism carditis) and specificity distinguishing the
      given disease. Spiroergometric examinations under a load of 1 w/kg is a highly
      informative method of evaluating the physical performance capacity of children
      with rheumatic heart diseases. By using this method it is possible to obtain
      quantitative and qualitative functional characteristics of their cardiopulmonary
      system, to disclose latent cardiac insufficiency. The data obtained help improve
      the rehabilitation of rheumatic patients.

PMID- 1021618
TI  - [Causes of hypercholesteremia in young pilots].

PMID- 1021619
TI  - [Arteriosclerosis in men doing physical and mental work].
AB  - In males engaged in doing physical and mental work a morphometric study with due
      consideration given to their condition of nurishment (in a group of practically
      healthy only), smoking habits and heteditary-familial history with respect to
      cardio-vascular diseases, was undertaken. Use was made of the autopsy materials
      obtaned in studying the epidemiology of atherosclerosis in some cities of the
      USSR. In persons doing brain work, well nourished, with long-standing smoking
      habits and adverse hereditary-familial history the intensity of atherosclerosis
      in the aorta and coronary arteries was more pronounced that in individuals doing
      manual work and exposed to the same risk factors. This gives reason to believe
      that the occupational factors does influence the development of atherosclerosis
      (above all in the coronary arteries) to a greater degree than the other ones,
      mentioned above.

PMID- 1021620
TI  - [Age-specific characteristics of functional disorders of the cardiovascular
      system and respiration in experimental atherosclerosis].
AB  - Results of investigations into age-specific peculiarities inherent in the
      contractile function of the cardiac ventricular myocardium, hemodynamics of the
      lesser circulation, oxygen supply of the organism in young (6--12 months old) and
      old (3 1/2--4 1/2 year old) rabbits in normalcy and with experimental
      atherosclerosis are reported. The contractility of the left ventricle myocardium
      in old animals was down as compared to the normal in young ones. Induction of
      atherosclerosis impairs this important function of the myocardium to a still
      greater degree. In old animals hemodynamics of the lesser circulation is
      characterized by a rising systolic pressure in the right ventricle and of the
      tension-time index (TTI) as contrasted against the young one in normalcy and with
      atherosclerosis. Against this background an additional action on the organism is
      attended by more pronounced pathological manifestations, i.e. in reactions of the
      cardiovascular system (including the lesser circulation). The initial
      manifestations of hypoxia recorded in older animals, as compared to the younger
      ones in normality, become more intensive in cases of induced atherosclerosis.
      There is reduced consumption of oxygen, oxygen saturation of arterial and,
      especially, mixed venous blood, as well as oxygen tension in the arterial blood.
      The recorded changes are of significance in clarifying the caused and conditions
      conducive to the development of atherosclerosis and to the intensification of its
      manifestations in an old organism.

PMID- 1021621
TI  - [Vascular plasmorrhagia in experimental hypertension].
AB  - The permeability of the vascular wall to the penetration into it of fibrinogen
      and serum protein in experimental hypertension of rats (ischemic renal and
      corticosteroid hypertension) was studied. Use was made of the indirect variant of
      Coons' method involving application of antisera to the mouse fibrinogen and to
      serum protein of rats. The development of the study models of experimental
      hypertension in rats was accompanied by an elevated vascular permeability and
      insudation of the plasma into the vasal wall. The disruption of the vascular
      permeability was more pronounced in arterioled of different organs of rats with
      DOCA-saline hypertension.

PMID- 1021622
TI  - [Cardiogenic shock in unanesthetized dogs].

PMID- 1021623
TI  - [Effect of disopyramide on the sino-atrial node].

PMID- 1021624
TI  - [Cardiac insufficiency caused by development of endocardial fibroelastosis after
      heart valve prosthesis].

PMID- 1021625
TI  - [Comparative clinico-physiological study of the effect of several MAO inhibitors
      in stenocardia].

PMID- 1021626
TI  - [Indicators of hemodynamics in patients with circulatory insufficiency after
      mitral commissurotomy].

PMID- 1021627
TI  - [Study of changes in the circulating blood volume after physical exertion in
      healthy persons].

PMID- 1021628
TI  - [Pathogenesis and classification of ischemic heart disease and methods of its
      diagnosis].

PMID- 1021629
TI  - [Comparative analysis of blood coagulation and various indicators of
      microcirculation in patients with coronary arteriosclerosis and hypertension in
      the age aspect].
AB  - In patients with hypertensive disease and coronary atherosclerosis the blood
      clotting potential increases on account of a rise in the level of procoagulants
      and inhibition of fibrinolysis. Age-specific differences in the characteristics
      of the coagulation and fibrinolytic system of the blood are levelled out parallel
      with the development of atherosclerosis and progressive evolution of hypertensive
      disease. In patients of advanced age a tendency toward a compensatory increased
      activity of erythrocytic anticoagulation  factors is noted, finding its
      expression in a drop of the procoagulants level, and increase of anticoagulants
      and in a rising fibrinolytic activity. Changes in the state of the conjunctival
      microcirculation and the retinal hemodynamics correlate with the intensity of the
      pathological process and shifts in the blood coagulation system.

PMID- 1021630
TI  - [Characteristics of pathogenesis of hypoxia in arterial hypertension in old age].
AB  - In 135 patients of advanced and senile age with essential hypertension
      hemodynamics and gas composition of the blood were investigated by the methods of
      the dye dilution after Stewart-Hamilton, Sechenov-van Slyke and micro-Astrup. The
      patients of this age category were found to suffer predominantly from the
      hemodynamic type of essential hypertension characterized by an increased cardiac
      ejection. Hypoxia develops chiefly after the hypoxic and tissular types. An
      increased cardiac ejection in patients of advanced and senile age with essential
      hypertension is considered to be a possible compensatory reaction to
      manifestations of hypoxia.

PMID- 1021631
TI  - [Indicators of bioelectric activity of the myocardium and gas exchange in
      threshold physical exertion of old patients with ischemic heart diseases].
AB  - ECG, pulmonary ventilation and gas exchange were recorded in 36 patients with
      ischemic heart disease and in 8 practically healthy persons of advanced age
      bearing a stepwise increasing physical load. In case of an obvious ischemic heart
      disease the tolerance of physical exertions was found to decline. Under a
      threshold physical load such patients demonstrate an excess ventilation; a
      decreased oxygen pulse and a lesser increment of the respiratory quotient, as
      well as a reduced coefficient of recovery, of the restored oxygen consumption
      rate, the respiratory rate, minute respiratory volume after exertion. In cases of
      a possible ischemic heart disease at advanced age the tolerance of physical
      efforts and a number of spiroergometric indices under a threshold load continue
      at the same level as in healthy people.

PMID- 1021632
TI  - [Mechanisms of development of cardiac insufficiency in old age].
AB  - Tests conducted with adult (8--10 months) and old (26--28 months) rats brought
      evidence that in ageing the cardiac ejection, dp/dt max, contractility index, the
      ATP concentration, that of creatinophosphate, glycogen, pyruvate decline, the
      phosphorylation coefficient, the lactate content increase, while the level of
      water-soluble proteins and collagen diminishes and that of water-insoluble ones
      decreases. In adult rats hemodynamics and myocardial contractility change but
      unsignificantly on the 4--6th day after coarctation of the aorta, whereas in the
      old ones there occur functional and metabolic alterations in the heart that are
      indicative of a developing cardiac insufficiency. The age-specific differences
      persist also on the 14--16th day following coarctation of the aorta. During these
      periods the weight of the heart, the content of the myofribrillary proteins and
      collagen are on the rise, whereas in the old ones the weight of the heart remains
      unchanged and the level of water-soluble protein drops. Changes in the properties
      of the actomyosin complex, disruption of the calcium pump, shifts in the system
      of the energy generation, limitation of potential possibilities incident to the
      systems of protein biosynthesis in the myocardial cell, all this leads to the
      development of cardiac incompetence following loading in old age.

PMID- 1021633
TI  - [Gerontological aspects of cardiology].
AB  - The growing interest to problems of geriatric cardiology the author associates
      with considerable demographic shifts (an increased proportion of th elderly
      people within the structure of the population); a clearer idea as to the part
      played by age-specific changes in an ageing organism in the development of the
      circulatory pathology; and with the need to take account of clinical
      peculiarities common to diseases involving the cardiovascular system in persons
      of advanced and senile age, of features specific for their therapy and
      prevention. The research trends along which geriatric cardiology develops are
      analyzed; basic data on age-specific changes and their relation with developing
      pathology of the cardiovascular system, obtained in animal experiments and
      observations of practically healthy subjects of advanced and senile age are
      discussed.

PMID- 1021634
TI  - [Characteristics of diagnosis and clinical course of rheumatic heart defects in
      middle- and old age].
AB  - In 56 patients aged over 60 years features peculiar to the diagnosis and the
      course of rheumatic heart diseases were studied. Clinical and laboratory
      findings, those of roentgenoscopy and roentgenography of the heart, as well as of
      electro- and phonocardiography were used. In 35 lethal cases clinico-anatomic
      comparisons and histological investigation were made for elucidating the activity
      of the rheumatic process. In persons aged over 60 the relapses of rheumatism have
      been found to be of rare occurrence and rheumatic affections run a course without
      any marked hypertension in the lesser circulation and become complicated by
      cardiac insufficiency no sooner than many years after establishiment fo the
      diagnosis. In individuals older than 60 an active rheumatic process according to
      histological investigations and the authors occurs in 14.3 per cent of the cases.

PMID- 1021635
TI  - [Jervell and Lange-Nielsen syndrome].
AB  - A rare case of the congenital cardiological syndrome of Jervell and Lange-Nielsen
      in a 6-year old boy is analyzed. A literature survey of the clinical picture,
      treatment of and prognosis in this and related to it the Romano-Ward syndrome is
      given.

PMID- 1021636
TI  - [Etiology of bacterial endocarditis in patients with congenital heart defects].
AB  - In 90 patients with various congenital heart diseases complicated by bacterial
      endocarditis multiple inoculations of the blood were practised. In 14 patients
      microbial cultures were planted postmortem with vegetation on the endocardium,
      valves and also from the thrombi in the cardiac chambers and from the spleen. In
      42.3 per cent of the cases a growth of microorganisms was recorded; a relation
      between the frequency of the microbial growth and the severity of endocarditis
      could be then noted. Among the planted microorganisms it was Staphylococcus albus
      that prevailed and this prompted the authors to consider it to be one of the
      principal causative agents of bacterial endocarditis in congenital heart diseases
      at this time. A significant proportion of the isolated microorganisms showed low
      sensitivity to most antibiotics. A relative frequency of negative hemocultures
      may be due to the use of antibiotics, the presence of forms "fruste" and indolent
      of endocarditis, a great variety of causative agents (including 1-forms of the
      bacteria) and to localization of endocardial lesions to the right heart chambers.

PMID- 1021637
TI  - [Clinical course, diagnosis and surgical treatment of congenital aortic
      stenosis].
AB  - In 39 patients aged from 2 1/2 to 35 years the results of surgical treatment of
      congenital aortic stenosis are analyzed. Electro-, phonocardiographic and
      roentgenological findings along with those obtained through catheterization of
      the left cardiac chambers prior to surgery are described in detail. All these
      patients were divided into 3 groups, depending upon extent of deranged
      hemodynamics. The 1st group included 10 persons with a moderate aortic stenosis.
      The systolic gradient between the left ventricle and the aorta did not exceed in
      them 30 mm Hg. The 2nd group counted 20 patients with a well-marked aortic
      stenosis and a systolic pressure gradient between 30 and 80 mm HG. The 3d group
      embraced 9 patients with an acute aortic stenosis. Here the systolic gradient was
      in excess of 80 mm Hg. Surgery was performed in 35 patients under a moderate
      hypothermia and with extracorporeal circulation. Thirteen (33.3 per cent)
      patients died during surgery and in the post-operative period.

PMID- 1021638
TI  - [Electrocardiographic diagnosis of patent ductus atrio-ventricularis].
AB  - The paper deals with the diagnosis of defective development of the patent ductus
      atrioventricularis. Electrocardiographic changes in 81 patients with firmly
      established hemodynamic form of the patent ductus atrioventricularis, ascertained
      during surgery and catheterization, are summarized. Characteristic
      electrocardiographic signs of the defect distinguishing it from other congenital
      diseases and differential-diagnostic symptoms of diverse anatomo-hemodynamic
      forms of the patent ductus atrioventricularis were educed.

PMID- 1021639
TI  - [Presence of the blood depot in orthostatic position and after physical
      exertion].
AB  - In healthy individuals and in patients with essential hypertension in the
      orthostatic position and on physical effort an insignificant reduction in the
      volume of the circulating blood and of the packed cell volume were in evidence;
      this being due to the outflow of the liquid part of the blood into the tissues.
      Even in instances of a well-marked orthostatic hypotonia, during medication with
      sympatholytic agents in particular, the circulating blood volume in the
      orthostatic position does not show any significant change. The results obtained
      by the authors and an analysis of the published data suggest that all of the
      blood is in circulation with none of it being repository or leaving the depot
      either in the orthostatic position or on physical effort.

PMID- 1021640
TI  - [Modern principles of transfusion therapy].

PMID- 1021641
TI  - [Effect of infusion therapy on the functional state of the kidneys in burn
      shock].

PMID- 1021642
TI  - [State of the body's oxygen supply in burn patients and some ways to correct
      hypoxia].

PMID- 1021643
TI  - [Medical work capacity expertise on patients with postburn trophic ulcer].

PMID- 1021644
TI  - [2 observations of necrotic mastitis].

PMID- 1021645
TI  - [Mammary fistulae].

PMID- 1021646
TI  - [Characteristics of the surgical treatment of middle-aged and elderly patients
      with abdominal pathology].

PMID- 1021647
TI  - The irreversible inhibitory effects of dibenamine on the noradrenaline-, K- and
      Ba-induced contractions of rat's isolated vas deferens, particularly in relation
      to Ca.

PMID- 1021648
TI  - The irreversible inhibitory effects of phenoxybenzamine on the noradrenaline-, K-
      and Ba-induced contractions of rat's isolated vas deferens, particularly in
      relation to Ca.

PMID- 1021649
TI  - Studies on drug nonequivalence. III. Rectal absorption of polymorphs of
      sulfathiazole.

PMID- 1021650
TI  - A fifteen-year follow-up on diabetes in a Japanese rural district.

PMID- 1021651
TI  - [External respiration in various body postures according to functional x-ray and
      radioisotopic study data].

PMID- 1021652
TI  - [Rapid determination of radionuclide activity in the human body].

PMID- 1021653
TI  - [Dosage loads on the hands in working with 99Mo--99mTe generators and 99mTc
      solutions].

PMID- 1021654
TI  - [Microcirculation in the human skin in burn trauma].

PMID- 1021655
TI  - [Study of cerebral blood flow in neurocirculatory dystonia using 133xe].

PMID- 1021656
TI  - [Modeling of the physical conditions of the measurement in interpreting the
      results of radioisotopic research].

PMID- 1021657
TI  - [Theoretical foundation of a method of determining blood volumes in the cavities
      of the heart by a radiocardiogram].

PMID- 1021658
TI  - [Scintigraphic study of the veins of the lower extremities].

PMID- 1021659
TI  - [Optimization of the geometry of linear scanning in measuring the complete
      radionuclide content unevenly distributed in the human body].

PMID- 1021660
TI  - [Minimal spatial resolution of a scintillation gamma chamber].

PMID- 1021661
TI  - [Auxiliary collimators for gamma teletherapy apparatus].

PMID- 1021662
TI  - [Vitamin B12 absorption disorders following radiation therapy].

PMID- 1021663
TI  - [Functional state of the adrenal cortex before and after combined radiation
      therapy of corpus uteri cancer].

PMID- 1021664
TI  - [Use of Sr85 for the evaluation of mineral metabolism in osteoarticular
      tuberculosis, osteomyelitis and rheumatoid polyarthritis].

PMID- 1021665
TI  - [Dynamic scintigraphy of the hepato-biliary system].

PMID- 1021666
TI  - [Scintigraphy in neoplastic and vascular diseases of the brain].

PMID- 1021667
TI  - [Cellular degeneration of the bone marrow as a criterion for the assessment of
      the absorbed dose and chemical protection].

PMID- 1021668
TI  - [Remote sequelae of occupational radiation exposure].

PMID- 1021669
TI  - [Graduation of the meters of absorbed dose of gamma irradiation].

PMID- 1021670
TI  - [Muscular blood flow depending on age and sex].

PMID- 1021671
TI  - [Photoscanning of the lungs and aspiration bronchography in chronic inflammatory
      diseases].

PMID- 1021672
TI  - [Method of measurement of the half-value layer of long-wave electromagnetic
      radiation].

PMID- 1021673
TI  - [Therapeutic effectiveness of 5-hydroxytryptamine, AMP and ATP in acute
      experimental radiation syndrome].

PMID- 1021674
TI  - [Characteristics of aseptic granulomatous inflammation in rats subjected to
      chronic effect of gamma irradiation in small doses].

PMID- 1021675
TI  - [Educational-methodological work at the Chair of radiology in a medical
      institute].

PMID- 1021676
TI  - [Radioisotope and morphological examination of the kidneys].

PMID- 1021677
TI  - Functional groups on enzymes suitable for binding to matrices.

PMID- 1021678
TI  - Adsorption and inorganic bridge formations.

PMID- 1021679
TI  - Techniques of enzyme entrapment in gels.

PMID- 1021680
TI  - Immobilization of enzymes to agar, agarose, and Sephadex supports.

PMID- 1021681
TI  - A method for continuous production of polyacrylamide-entrapped enzyme beads.

PMID- 1021682
TI  - Microencapsulation of enzymes and biologicals.

PMID- 1021683
TI  - Enzyme entrapment in liposomes.

PMID- 1021684
TI  - Photochemical immobilization of enzymes and other biochemicals.

PMID- 1021685
TI  - Nonaqueous synthesis of polystyryl lysozyme.

PMID- 1021686
TI  - Physical immobilization of enzymes by hollow-fiber membranes.

PMID- 1021687
TI  - Immobilized enzymes.

PMID- 1021688
TI  - Immobilized enzymes--miscellaneous methods and general classification.

PMID- 1021689
TI  - Assay procedures for immobilized enzymes.

PMID- 1021690
TI  - Characterization of immobilized enzymes by chemical methods.

PMID- 1021691
TI  - Activity correlations between similarly modified soluble and immobilized enzymes.

PMID- 1021692
TI  - The glucose oxidase--catalase system.

PMID- 1021693
TI  - Immoblization of enzymes to various acrylic copolymers.

PMID- 1021694
TI  - Immobilized hemoproteins.

PMID- 1021695
TI  - Mechanochemistry of immobilized enzymes: a new approach to studies in fundamental
      enzymology. I. Regulation by mechanical means of the catalytic properties of
      enzymes attached to polymer fibers.

PMID- 1021696
TI  - Mechanochemistry of immobilized enzymes: a new approach to studies in fundamental
      enzymology. II. Regulation of the rate of enzymic protein-protein interaction in
      polyacrylamide gel.

PMID- 1021697
TI  - Immobilized enzymes in microcalorimetry.

PMID- 1021698
TI  - Enzyme thermistor devices.

PMID- 1021699
TI  - Methods for the therapeutic applications of immobilized enzymes.

PMID- 1021700
TI  - Medical applications of liposome-entrapped enzymes.

PMID- 1021701
TI  - Immobilized-enzyme reactors.

PMID- 1021702
TI  - Process engineering of glucose isomerization by collagen-immobilized whole
      microbial cells.

PMID- 1021703
TI  - Continuous production of high-fructose syrup by cross-linked cell homogenates
      containing glucose isomerase.

PMID- 1021704
TI  - Enzymes covalently bound to polyacrylic and polymethacrylic copolymers.

PMID- 1021705
TI  - [Neuropathy due to glues : hypothesis and facts].

PMID- 1021706
TI  - [Etiology of polyneuritides due to glues : experimental studies on the
      neurotoxicity of n-hexane].

PMID- 1021707
TI  - [Determination of urinary delta-aminolevulinic acid using a descrete automatized
      analyzer].

PMID- 1021708
TI  - [Syndrome due to estrogen-progestogens in a worker engaged in the production of
      contraceptive agents].

PMID- 1021709
TI  - [Normal values of free protoporphyrin IX studied in 256 male adult subjects
      living in Lombardia].

PMID- 1021710
TI  - [Heart arrhythmias in acute intoxication due to commercial trichlorethylene].

PMID- 1021711
TI  - [A case of acute poisoning due to trichloroethylene complicated by myocardial
      infarct].

PMID- 1021712
TI  - [Heat balance in marathon running].

PMID- 1021713
TI  - [Determination of trichloroacetic acid in the urine : control of quality and
      accuracy].

PMID- 1021714
TI  - Hemigonadectomy-induced unilateral changes in the protein-synthesizing activity
      of the rat hypothalamic arcuate nucleus.
AB  - The effect of unilateral ovariectomy on the protein-synthesizing activity of the
      hypothalamic arcuate and dorsomedial nucleus on both sides was studied in vivo as
      well as in vitro. Four weeks after the removal of 1 ovary, there was a
      significant increase in labelled amino acid incorporated into the arcuate neurons
      contralateral to the removed ovary as compared to those incorporated into the
      nerve cells of the nucleus on the ipsilateral side. In the dorsomedial nucleus,
      there was no difference between the 2 sides. On the basis of the present
      findings, the existence of a neural pathway between the ovary and the
      hypothalamic arcuate nucleus is assumed.

PMID- 1021715
TI  - Temporal effects of fornix transection on brain tryptophan hydroxylase activity
      and plasma corticosterone levels.
AB  - The effect of fornix transection on plasma corticosterone and on midbrain (MID),
      septum/preoptic (S/POA) or hippocampal (HIP) tryptophan hydroxylase activity
      (THA) was studied in adult male rats. A mild stress resulted in higher levels of
      plasma corticosterone in operated as compared to sham-operated rats 6 and 40 h
      post-transection; however, at 30 days post-operation no difference was found. The
      response of THA to fornix transection was region-specific. No significant change
      in the S/POA region was found at any time. THA in the HIP, a terminal area of 5
      HT fibers, showed a progressive fall over time to values 80% below normal levels.
      This result suggests that most of the 5-HT fibers to the HIP had been severed. A
      28 h half-life for HIP THA was calculated. THA in the MID, an area known to
      contain the majority of 5-HT cell bodies with ascending fibers, was significantly
      reduced compared to sham controls at 6 h, 40 h, and 8 days post-transection.
      However, at 30 days post-operation no difference was found. The depression in MID
      THA by its rapid onset, the distance from the fornix transection site, and its
      return to normal after 30 days, is thought to be due to a transneuronal effect on
      the serotonin-containing neurons in MID raphe. The fall in MID THA at a time when
      plasma corticosterone levels are increased in fornix-transected rats may be
      compared with the situation in normal, stressed and adrenalectomized rats where
      MID THA andplasma corticosterone levels change in the same direction. The data
      suggest that the glucocorticoid effects on MID 5-HT containing neurons are
      mediated transneuronally through the hormone concentrating cells in the HIP.

PMID- 1021716
TI  - In vivo nuclear 3H-estradiol binding in brain areas of the rat: reduction by
      endogenous and exogenous androgens.
AB  - In vivo specific nuclear binding of [2, 4, 6, 7 (n)-3H]estradiol (3H-E2) as
      indicated by diethylstilbestrol (DES)-blockable radioactivity, was measured 1 h
      after injection in adult intact male, untreated and testosterone propionate (TP)
      pretreated or 5alpha-dihydrotestosterone (DHT)-pretreated gonadectomized (GDX)
      male and female rats. There was no sex difference in specific 3H-E2 binding in
      brain areas and anterior pituitary (PIT) of untreated GDX animals. DHT
      pretreatment had no effect on binding in any tissue. Specific nuclear binding in
      the preoptic area-anterior hypothalamus (POA-AH), median eminence-basal
      hypothalamus (ME-BH), amygdala (AMYG), septum (SEP), and dorsal hypothalamus (DH)
      was lower in intact males and TP-pretreated GDX males and females than in
      untreated GDX animals. Uptake in the PIT was not affected by TP pretreatment or
      by the presence of the testes, suggesting that the reduction in nuclear 3H-E2
      binding observed in other tissues was caused by competition by estradiol formed
      in situ from TP or endogenous androgens for nuclear binding sites. Thus, the
      reduction in 3H-E2 uptake caused by the presence of TP or the testes could be
      used to estimate the degree of aromatization that occurred in these brain areas.
      In males, specific nuclear binding of 3H-E2 was reduced by the presence of the
      testes by 60-70% in the POA-AH and AMYG, by 30-40% in the ME-BH and SEP and by 0
      20% in the DH. After s.c. administration of 1 mg/kg TP in GDX males, the amount
      of estrogen formed after 1,5 h in these same tissues approximated that present in
      the steady state in intact males. This suggests that, in the intact adult male
      rat, a high percent of estradiol nuclear binding sites in some brain areas is
      normally occupied by the products of aromatization.

PMID- 1021717
TI  - [Combination ethrane-pancuronium in anesthesiological practice].

PMID- 1021718
TI  - [Althesin as a maintenance anesthetic in minor and major surgery].

PMID- 1021719
TI  - [Potentiated analgesia in bronchoscopy (clinical results)].

PMID- 1021720
TI  - [Controlled clinical evaluation of althesin in the induction to general
      anesthesia].

PMID- 1021721
TI  - [Effects of Ethrane  administration on pulmonary structure. III. ultrastructural
      localization of acid phosphatase activity].

PMID- 1021722
TI  - [Electroanesthesia. Characteristics and function of a new apparatus for
      electronarocosis (preliminary note)].

PMID- 1021723
TI  - [Clinical use of a new intravenous anesthetic : etomidate. Introductory note].

PMID- 1021724
TI  - [Treatment of post-traumatic floating costal flaps].

PMID- 1021725
TI  - [New method of general anesthesia for bronchoscopy].

PMID- 1021726
TI  - [Phenomenon of suppression of light diffusion figures in myopia].

PMID- 1021727
TI  - [Is school myopia a handicap?].

PMID- 1021728
TI  - [Fusion reserves in children].

PMID- 1021729
TI  - [Diagnosis of A-V-X syndromes in squint].

PMID- 1021730
TI  - [Experience with a drug complex for stabilization of visual functions in
      glaucomatous patients].

PMID- 1021731
TI  - [Peculiarities of hydrodynamics of the eye in aborigines of Far North].

PMID- 1021732
TI  - [Hydrodynamic indices and visual functions in primary subcompensated glaucoma].

PMID- 1021733
TI  - [Influence of annular perilimbal compression on intraocular pressure in healthy
      eyes].

PMID- 1021734
TI  - [Prevention of choroidal detachment following cryoextraction of senile cataract].

PMID- 1021735
TI  - [Histochemical characteristics of the epithelium and lens capsule of the rabbit
      eye (nucleic acids, proteins, lipids, polysaccharides)].

PMID- 1021736
TI  - [Objective method for study of the cornea by its dielectric parameters].

PMID- 1021737
TI  - [Usage of polarization microscopy for examination of the lens].

PMID- 1021738
TI  - [Morphology and morphological criteria for malignant pigmentary neoplasms of the
      uveal tract in man].

PMID- 1021739
TI  - [Treatment of disbinocular ambylopia using direct occlusion].

PMID- 1021740
TI  - [New method of amblyopia treatment with correct fixation].

PMID- 1021741
TI  - [Method of standardization of experimental thermal eye burns].

PMID- 1021742
TI  - [Chart of a united dispensary observation of patients with diabetes mellitus].

PMID- 1021743
TI  - [Occlusion amblyopia in a healthy eye].

PMID- 1021744
TI  - [Diagnostic difficulties in late hydrophthalmos].

PMID- 1021745
TI  - [Influence of position of the optic axis on the tolerance of correction of myopic
      iso- and anisometropia].

PMID- 1021746
TI  - [Role of autonomic innervation of accommodation in creation of optic adjustment
      of the eye with divers refraction].

PMID- 1021747
TI  - [Accommodation of aphakic eye].

PMID- 1021748
TI  - [Etiopathogenesis of true accommodation spasm and acquired progressive myopia].

PMID- 1021749
TI  - [Rehabilitation of patients after penetrating wounds of the eyeball with changes
      in the vitreous body].

PMID- 1021750
TI  - [Disability after eye injuries and the tasks of rehabilitation].

PMID- 1021751
TI  - [Main medico-social characteristics of disability after severe sequelae of eye
      injuries].

PMID- 1021752
TI  - [Dispensarization as a stage of rehabilitation in sequelae of eye injuries in
      machine-building industry].

PMID- 1021753
TI  - [Remote results of surgical treatment of high progressive myopia].

PMID- 1021754
TI  - [Certain characteristics of clinical course of congestive disks in various brain
      diseases].

PMID- 1021755
TI  - [Change in corneal refraction after cataract cryoextraction].

PMID- 1021756
TI  - [Oxygen therapy of toxic optic neuritis of persons working in contact with
      nitroderivatives of toluol].

PMID- 1021757
TI  - [Zymosan therapy in high myopia].

PMID- 1021758
TI  - [Electromyographic studies in disorders of eye movements with concomitant
      pathologic contractions].

PMID- 1021759
TI  - [Formation of the pathway for outflow of intraocular fluid after trabeculectomy].

PMID- 1021760
TI  - [Simulation of disorders of visual functions in children].

PMID- 1021761
TI  - [Condition of the eye under the effect of various organophosphate compounds in
      chronic animal experiments].

PMID- 1021762
TI  - [Etiopathogenesis and effectiveness of treatment of dysbinocular amblyopia with
      incorrect fixation].

PMID- 1021763
TI  - [Organization of ophthalmological trauma centers].

PMID- 1021764
TI  - [Organization of the district physiotherapeutic service for patients with eye
      diseases].

PMID- 1021765
TI  - [Limbal incision of the conjunctiva in strabismus].

PMID- 1021766
TI  - [Clinical course and treatment of patients with injuries of neurovascular
      structures of the orbit in zygomatic fractures].

PMID- 1021767
TI  - [Uveoencephalitis (Harada's disease)].

PMID- 1021768
TI  - [Prevention and treatment of the complications of penetrating
      prosthokeratoplasty].

PMID- 1021769
TI  - [Complications after penetrating prosthokeratoplasty operations, their prevention
      and treatment].

PMID- 1021770
TI  - [Late complications of penetrating prosthesis in leucomas].

PMID- 1021771
TI  - [State of local and general hemodynamics in glaucoma and systemic vascular
      diseases].

PMID- 1021772
TI  - [Valval basal iridencleisis with thinning of the deep layers of the sclera
      (direct observations)].

PMID- 1021773
TI  - [Combined treatment of orbital sarcoma in children (late observations)].

PMID- 1021774
TI  - [Effect of the radius of the corneal curvature on the hydrodynamic indices].

PMID- 1021775
TI  - [Echobiometry of eye changes depending on the refraction in opaque media].

PMID- 1021776
TI  - [Characteristics of the ploidy, quantity of cytoplasmic RNA and the activity of
      oxidative-reductive enzymes in melanoblastomas of the vascular tract of the human
      eye].

PMID- 1021777
TI  - [Characteristics of the development of a melanoblastoma of the vascular membrane
      of the human eye transplanted into the anterior chamber of the rabbit eye].

PMID- 1021778
TI  - [Results of a discussion of the possibility of curing disbinocular amblyopia by
      modern methods according to data from immediate and late observations].

PMID- 1021779
TI  - [Magnifier for reading].

PMID- 1021780
TI  - [Some suggestions for providing equipment for ophthalmic microsurgery].

PMID- 1021781
TI  - [Histoenzymatic diagnosis of congenital megacolon].

PMID- 1021782
TI  - [Proposal of a method for the cytological identification of mesotheliomas].

PMID- 1021783
TI  - [Breast sclero-elastotic focal lesions simulating infiltrating carcinoma].

PMID- 1021784
TI  - [Suggested changes in current laws dealing with the activities of pathological
      anatomy departments].

PMID- 1021785
TI  - [A case of skin tanning syndrome as a complication of phototherapy].

PMID- 1021786
TI  - [A case of Wiskott-Aldrich syndrome with specific immunological deficiencies].

PMID- 1021787
TI  - [A case of congenital nephrotic syndrome with onset in the 1st month of life].

PMID- 1021788
TI  - [Growth, the infant and his nutrition (bio-physiological aspects)].

PMID- 1021789
TI  - [Various findings on the use of cephalexin in pediatric treatment].

PMID- 1021790
TI  - [Angiography in the diagnosis of splenic cysts].

PMID- 1021791
TI  - [Chromosome abnormalities in Fanconi's anemia (review of literature and study of
      a case)].

PMID- 1021792
TI  - [Syndrome of disseminated intravascular coagulation during a course of idiopathic
      pancytopenia].

PMID- 1021793
TI  - [Pyruvate kinase deficiency ass3ciated with nonspherocytic hemolytic anemia.
      Biochemical hematological study of 3 cases].

PMID- 1021794
TI  - [Comparative evaluation of 2 methods for the determination of serum alkaline
      phosphatase in childhood].

PMID- 1021795
TI  - [Clinical aspects and diagnosis of celiac disease].

PMID- 1021796
TI  - ["Harmonic" short stature child (diagnostic methods, indications and limiations
      in management unit somatotropin)].

PMID- 1021797
TI  - [Kidney disease due to reflux].

PMID- 1021798
TI  - [Current status and perspectives of asthma therapy in children].

PMID- 1021799
TI  - [Diagnostic problems with congenital heart diseases in neonatal age].

PMID- 1021800
TI  - [Towards a new bacteriology].

PMID- 1021801
TI  - [Problems and practice of health education in hospital (proceedings)].

PMID- 1021803
TI  - [The physician in the rehabilitation team (proceedings)].

PMID- 1021802
TI  - [The physician in practice (proceedings)].

PMID- 1021804
TI  - [Dependences (proceedings)].

PMID- 1021805
TI  - [Nutrition (proceedings)].

PMID- 1021806
TI  - [Movement (proceedings)].

PMID- 1021807
TI  - [Stress (proceedings)].

PMID- 1021808
TI  - [Health and emotional stability. What can the educator in the school contribute?
      (proceedings)].

PMID- 1021809
TI  - [The co-worker in adult education (proceedings)].

PMID- 1021810
TI  - [Stability of students through teacher-student interaction (proceedings)].

PMID- 1021811
TI  - [Continuing education, "medicine" for the aged (proceedings)].

PMID- 1021812
TI  - [Aim of learning--health and emotional stability (proceedings)].

PMID- 1021813
TI  - [Flow-volume curve in patients with mitral valve disease (author's transl)].

PMID- 1021814
TI  - [Expiratory flows in children: normal values (author's transl)].

PMID- 1021815
TI  - [Acute peptic ulcer perforation: immediate and delayed results (author's
      transl)].

PMID- 1021816
TI  - [Pancreatic abscess (author's transl)].

PMID- 1021817
TI  - [Pseudomonas pseudomallei infections: clinical and bacteriologic significance
      (author's transl)].

PMID- 1021818
TI  - [The in vitro sensitivity of 24 strains of pseudomonas pseudomallei to
      antibiotics (author's transl)].

PMID- 1021819
TI  - [Non-cardiogenic intersticial pulmonary edema associated with blood transfusion
      reaction (author's transl)].

PMID- 1021820
TI  - [Felty's syndrome complicated by hemolytic anemia. Favourable effect of
      splenectomy (author's transl)].

PMID- 1021821
TI  - [The Moraxella lwoffi group of bacteria (author's transl)].

PMID- 1021822
TI  - [Ventricular response to different types of overload (author's transl)].

PMID- 1021823
TI  - [Students evaluation of the teaching of preventive and social medicine (author's
      transl)].

PMID- 1021824
TI  - [Rising costs in medicine (author's transl)].

PMID- 1021825
TI  - [Introduction to the study of primary energizers and hydrosaline metabolism].

PMID- 1021826
TI  - [Asthma and the vagus route].

PMID- 1021827
TI  - [Variability in the X-ray diagnosis of early silicosis].

PMID- 1021828
TI  - [A prospective drug surveillance study of gi patients performed by physicians and
      by pharmacist (author's transl)].

PMID- 1021829
TI  - [Results of photocoagulation in 111 eyes with diabetic retinopathy (author's
      transl)].

PMID- 1021830
TI  - [Thrombosis of varicose veins in the lower extremities. an experience with 334
      patients (author's transl)].

PMID- 1021831
TI  - [Accuracy of the preoperative diagnosis of thyroid cancer in patients with
      nodular goiter (author's transl)].

PMID- 1021832
TI  - [Hepatitis due to nitrofurantoin (author's transl)].

PMID- 1021833
TI  - [Chronic diarrhea due to congenital isomaltase defficiency (author's transl)[].

PMID- 1021834
TI  - [Mediastinoscopy: an experience with 26 cases (author's transl)].

PMID- 1021835
TI  - [A clinical approach to the thyropathic patient (author's transl)].

PMID- 1021836
TI  - [Arrhythmias: its pronostic significance in cardiac dieases (author's transl)].

PMID- 1021837
TI  - [Advances in the treatment of bronchial asthma].

PMID- 1021838
TI  - [The effect of duodenum acidification upon gastric emptying in the rat. Pyloric
      sphincter role (author's transl)].

PMID- 1021839
TI  - [Pollinization periods in the urban area of Santiago, 1975-1976 (author's
      transl)].

PMID- 1021840
TI  - [Treatment of chronic amebiasis with nitrimidazole (author's transl)].

PMID- 1021841
TI  - [The effect of messoinositol hexanicotinate on the treatment of primary
      hyperlipidemia (author's transl)].

PMID- 1021842
TI  - [Total proctocolectomy for severe ulcerative colitis (author's transl)].

PMID- 1021843
TI  - [The effect of cotrimexazole on enteral infections due to Salmonellae in infants
      (author's transl)].

PMID- 1021844
TI  - [Pituitary function in a case of empty sella syndrome (author's transl)].

PMID- 1021845
TI  - [Actinomycosis of the liver (author's transl)].

PMID- 1021846
TI  - [The pathophysiology of stress. Part 1 (author's transl)].

PMID- 1021847
TI  - [The use of biochemical terms in spanish language (author's transl)].

PMID- 1021848
TI  - [An epidemiologic survey of accidents at work in Santiago, Chile (author's
      transl)].

PMID- 1021849
TI  - [Lupus nefropathy. A clinical-morphologic correlation (author's transl)].

PMID- 1021850
TI  - [Non ketoacidotic hyperosmolar diabetic coma (nkhdc) (author's transl)].

PMID- 1021851
TI  - [Effects of lidocaine on atrio-ventricular conduction (author's transl)].

PMID- 1021852
TI  - [Gastric outlet obstruction: medical and surgical results (author's transl)].

PMID- 1021853
TI  - [Relapsing polychondritis (author's transl)].

PMID- 1021854
TI  - [Mechanism and molecular basis of bile acid transport in the liver (author's
      transl)].

PMID- 1021855
TI  - [Pancreatic pseudocysts (author's transl)].

PMID- 1021856
TI  - [Science: the first condition of the university (author's transl)].

PMID- 1021857
TI  - [The need to trust the chilean university (author's transl)].

PMID- 1021858
TI  - [Arterial hypertension, an important public health problem (author's transl)].

PMID- 1021859
TI  - [New approach to sudden death].

PMID- 1021860
TI  - [Basic notes on bronchiectasis].

PMID- 1021861
TI  - [Hemophilia and arterial hypertension (author's transl)].

PMID- 1021862
TI  - [Induction of cleft palate in ball mice: the comparative effect of 5
      fluorouracil, phenylbutazone and water and food deprivation (author's transl)].

PMID- 1021863
TI  - [A clinical, radiologic and functional study in arc welders and oxyacetylene
      cutters (author's transl)].

PMID- 1021864
TI  - [Epilepsy refractary to usual treatment: the effect of clonazepam (author's
      transl)].

PMID- 1021865
TI  - [Erythroblastopenic anemia as first manifestation of a systemic lupus
      erythematosus (author's transl)].

PMID- 1021866
TI  - [Osteomalacia secondary to chronic metabolic acidosis (author's transl)].

PMID- 1021867
TI  - [Reiter's syndrome (author's transl)].

PMID- 1021869
TI  - [The doctor-patient relationship (author's transl)].

PMID- 1021868
TI  - [Clinical evaluation of strip tests for urinary proteins assay (author's
      transl)].

PMID- 1021870
TI  - [Endemic goiter in Chile (author's transl)].

PMID- 1021871
TI  - [Brief breast feeding: high risk in developing countries].

PMID- 1021872
TI  - [Cigarettes and respiratory function tests].

PMID- 1021873
TI  - [Changes in the erythrocyte membrane during blood preservation. Influence of
      progesterone].
AB  - Modifications of the erythrocyte membrane during blood conservation are studied.
      The functional condition of the membrane was observed by means of the
      biosynthesis of lecithines; modifications occurring at the level of the
      composition of the membrane proteins were then looked for. The study has been
      carried out on fresh blood and on blood stroed for 8 days, 15 days, 29 days and
      43 days. Another series of assays has been done on stored blood in the presence
      of progesterone after the  same conservation periods. The metabolic activity of
      the membrane, in the lecithine biosynthesis is studied by measuring the
      incorporation of fatty acid in the lysolecithines when the membrane is incubated
      in the presence of linoleic acid or [14] palmitic acid and coenzyme A, or in the
      presence of [14C] palmitoyl coenzyme A. Variations have been observed during
      blood conservation: the incorporation or radioactive fatty acid increases during
      the first 15 days of conservation, then it decreases to a value nearing the
      original value after 43 days. When the blood is stored in the presence of
      progesterone (1,6 mumole/1) a more stable incorporation of the fatty acid is
      observed; variations during conservation are weaker than without progesterone.
      Membrane proteins have been studied by electrophoresis on polyacrylamide gel
      after solubilisation by sodium dodecyl sulfate. The intensity of protein zones
      after coloring, decreases during conservation especially in proteins with a high
      molecular weight. A quantitative study has been made by chromatography on
      Sephadex G200 of dansylated proteins with a fluorimetric dosage. In the presence
      of progesterone, the decrease of the rate of proteins with a high molecular
      weight is weaker. Therefore, progesterone is proved to allow a better
      conservation of erythrocyte membrane proteins. As a conclurion, the results of
      these works show a positive action of progesterone on the erythrocyte membrane
      during blood conservation.

PMID- 1021874
TI  - [The role of immigration in the geographic distribution of the HBs antigen].
AB  - The study of HBs antigen frequency among almost 130 000 donors,--according to
      their place of birth--,shows a significantly higher frequency among foreign
      residents. The general frequency represents the arithmetic average between that
      of natives and that of foreign residents. The distribution of ad and ay subtypes
      is analogous to that observed in the different native countries.

PMID- 1021875
TI  - [Family diffusion of HBs antigen].
AB  - Systematic investigation for HBs antigen and for HBs antibody in donors carrying
      HBs antigen evidenced a familial contamination more important in children and
      first cousins than in husband and wife which confirm various previous studies.
      Moreover, daughters and sisters of antigen carriers show an abnormaly high
      antigen frequency and especially an abnormally low antibody frequency.

PMID- 1021876
TI  - [Hepatitis B and ratio of masculinity].
AB  - Among families of blood donors from Languedoc, found to be chronic carriers of
      HBs antigens, the masculinity ratio of the siblings (number of boys compared to
      number of girls) calculated on 303 individuals is significantly higher (1,32)
      than that of the general population (1,05). This rise is still increased when
      considering only the families where the viral infection is present in the mother
      (1,73), whereas it is very low when in the father (1,09).

PMID- 1021877
TI  - [Age and sex of chronic carriers of HBs antigen among 130,000 blood donors].
AB  - The frequency of HBs antigen, using radioimmunology is studied in blood donors
      from Languedoc (70.894 men and 60.760 women are tested, between 18 and 60 years
      old). The frequency in man is found to be 0,6 %, except between 20 and 30 years
      whereas it reaches 1,0 %; the frequency in woman is 0,4 % except between 18 and
      36 years where it is 0,4 %.

PMID- 1021878
TI  - [Diethylhexyl phthalate in plastic bags and glass bottles for blood
      preservation].
AB  - The amount of di-(-2 ethyl hexyl) phtalate (D.E.H.P.) is measured in the liquid
      contained in plastic bags or glass bottles for blood storage. Comparisons between
      the results show that D.E.H,P. has an equal level in plastic and glass container
      liquid except for one blood packs series. Particular attention has been paid to
      obtain solvents and glassware free from D.E.H.P., and to the specificity and the
      sensitivity of the detection method: a mass fragmentographic technic has been
      used.

PMID- 1021879
TI  - [Case report. Presumption of transfusion malaria].

PMID- 1021880
TI  - [Minutes of the 11th international symposium. Separation and transfusion of
      leukocytes. London - Royal Postgraduate Medical School October 11, 12, 13, 1976
      (proceedings)].

PMID- 1021881
TI  - [Precancerous diseases of the large intestine].

PMID- 1021882
TI  - [Endoscopic diagnosis of early stomach cancer].

PMID- 1021883
TI  - ["Immunoblastic" lymphadenitis in systemic lupus erythematosus].

PMID- 1021884
TI  - [Mitral valve stenosis in systemic lupus erythematosus (SLE)].

PMID- 1021885
TI  - [Case of periodic disease associated with Bechterew's disease].

PMID- 1021886
TI  - [Syndrome of mitral valve flap prolapse].

PMID- 1021887
TI  - [Hamman-Rich syndrome].

PMID- 1021888
TI  - [Lyell's and Stevens-Johnson syndromes].

PMID- 1021889
TI  - [Pseudosclerodermic conditions].

PMID- 1021890
TI  - [Sjogren's syndrome (detailed description)].

PMID- 1021891
TI  - [Study of DNA-binding activity of blood serum in systemic lupus erythematosus,
      rheumatoid arthritis and crossing syndromes].

PMID- 1021892
TI  - [Circulation of antigen-binding lymphocytes sensitized to tissue antigens in
      rheumatism].

PMID- 1021893
TI  - [Elaboration of objective evaluation of the activity of rheumatoid synovitis].

PMID- 1021894
TI  - [Certain aspects of electrolyte (Na, K and Ca) metabolism in patients with
      rheumatic heart disease].

PMID- 1021895
TI  - [Clinico-functional characteristics of the esophagus in rheumatoid arthritis and
      systemic lupus erythematosus in comparison with systemic scleroderma].

PMID- 1021896
TI  - [Various problems of drug treatment of rheumatoid arthritis].

PMID- 1021897
TI  - [Current state of treatment of rheumatoid arthritis and systemic lupus
      erythematosus with cytotoxic drugs].

PMID- 1021898
TI  - [Comparative results of treatment by intra-articular administration of
      cyclophosphamide of patients with rheumatoid arthritis with different
      immunological characteristics of the pathological process].

PMID- 1021899
TI  - [Clinical aspects of rheumatic polymyalgia].

PMID- 1021900
TI  - [Possibilities of early diagnosis of large intestine cancer].

PMID- 1021901
TI  - Some surgical aspects of gastric disorders.

PMID- 1021902
TI  - [Rectal prolaps in children and adults].

PMID- 1021903
TI  - Diagnosis of lambliasis by fibre-endoscopy.

PMID- 1021904
TI  - [Cleansing of the colon using whole gut irrigation].

PMID- 1021905
TI  - [Characteristics of the DNA of active sludge adapted to various carbon sources].
AB  - Some characteristic are presented for DNA of active sludge adapted to domestic
      waste, diethylene glycol, mannitol and glycerol. A significant shift towards CG
      type is found for the nucleotide composition of the DNA of active sludge adapted
      to glycerol and mannitol. The fusion curves for DNA of the active sludge evidence
      for the presence of some totality of molecules in it. In case of the diethylene
      glycol adapted active sludge DNA fusion two transitions are observed
      corresponding to 37.8 and 68.2 mol.% of GC-pairs, that may be explained by
      bimodality in distribution of the number of species of the free-living bacteria
      according to the DNA nucleotide composition. The fusion curves for DNA of the
      active ooze adapted to domestic waste, mannitol and glycerol has no clearly
      pronounced transitions, that may be explained by the presence of other groups of
      microorganisms in these sludges, besides bacteria. Heterogeneity of DNA relative
      to the nucleotide composition with transition to a single source of carbon
      decreases in the series: initial active sludge greater than active sludge adapted
      to mannitol greater than glycerol greater than diethylene glycol.

PMID- 1021906
TI  - [Changes in the protein content and their amino acid makeup in the muscles in
      feeding rats corn with an increased lysine content].
AB  - The biochemical indexes of the rat muscles  were studied as affected by maize
      with a higher content of lysin. It is shown that a month after an increase in the
      body weight and mass of muscles are more pronounced in the rats which were fed
      maize with a higher content of lysin. The latter, evidently, is due to an
      increase in the content of sarcoplasmatic proteins, RNA, as well as macroergic
      compounds, ATP and creatine phosphate, in the muscle of the animals under
      experiment. The qualitive composition of muscles proteins changes in these
      animals. A rated gain in essential amino acids is observed as compared to the
      control group. Hence the feeding of the maize with a higher content of lysin to
      animals may increase the feed value of meat products.

PMID- 1021907
TI  - [Action of acid cathepsins on the myosin and sarcoplasmic proteins of normal and
      denervated rat muscles].
AB  - The activity of acid cathepsins in extracts of the healthy and denervated rat
      muscles was determined, using the proper and homologous sarcoplasmic proteins and
      myosin as substrates. Splitting of the sarcoplasmic proteins produces a 50%
      increase and that of myosin produces a 110% increase in the activity of acid
      cathepsins of the denervated muscles as compared to that of healthy ones.
      Substrates isolated from the healthy and denervated muscles are splitted by acid
      cathepsins with the same intensity.

PMID- 1021908
TI  - [Effect of glutamate on the trace element content in the mitochondria of the
      liver, heart and kidneys of rats with acute and chronic hypoxia].
AB  - Acute hypoxia ("height" 8000 metres, 60 minutes) decreases concentration of
      copper, zinc and magnesium in mitochondria of the liver, kidney, that of copper
      and magnesium decreases in the heart. Chronic hypoxia ("height" 6000 metres, 6
      hours a day for 2 weeks) also causes a decrease in the concentration of copper,
      zinc and magnesium in mitochondria of the liver, kidney and that of copper and
      magnesium--in the heart. Glutamic acid (acute and chronic hypoxia) increases the
      level of copper, zinc and magnesium in mitochondria of the liver, heart and
      kidney of albino rats which is close to its values in the normal animals.

PMID- 1021909
TI  - [Glucose content in the tissues of susliks and rats of different ages under
      hypothermia].
AB  - A short-term cooling of adult rats and gophers up to 30, 25 and 20 degrees C is
      accompanied by a rise of the glucose level in blood. No dependence is found
      between lowering the body temperature drop and degree of glycaemia. Prolongation
      of hypothermia of 30 and 20 degrees C up to 3 h causes (as compared to the
      control) a decrease in the glucose amount in blood of gophers but not in the
      rats. The cooling of the eye-opening, month and adult rats up to 20 degrees C is
      accompanied by a significant increase in the content of glucose in the brain and
      skeletal muscles. Simultaneously in the eye-opening and adult animals, contrary
      to the month ones, the level of glucose in the liver and blood rises. The content
      of glucose in the brain of the normothermal gophers (61.2 mg.) is 3,4 times as
      high as in the rat brain. At all the studied stages of artificial hypothermia as
      well as at 15 and 30-day hibernation (5 degrees C) the amount of glucose of the
      gopher brain remains at a relatively high level (41.6-101.5 mg%).

PMID- 1021910
TI  - [Characteristics of the label incorporation from 2-14C-glycine into the tissues
      of animals of differing ages].
AB  - Peculiarities of 14C incorporation into proteins and lipids of the liver,
      kidneys, heart and muscles tissues as well as blood serum and protein-free
      filtrates of tissues were studied in young and old rats in different periods
      after glycin-2-14C administration. It is shown that incorporation of 14C into the
      tissue of young rats as well as its evacuation from the organism is more rapid.
      At the same time a change in dynamics of the precursors content in individual
      organs of animals of both age groups is of indirected character. A conclusion is
      drawn that acceleration of the radioactive label evacuation due to a more rapid
      exchange--ability of proteins in the young animals tissues might be one of the
      reasons of discrepancy between a higher level of radioactivity in the tissues of
      old rats and a total decrease in the intensity of metabolism during ontogenesis.

PMID- 1021911
TI  - [Dielectric permeability and the specific resistance of a freshly obtained myelin
      preparation].
AB  - The article deals with dispersion of dielectric constant and specific resistance
      of myelin obtained by the Autilio method from white substance of the cattle brain
      within frequency range of 90 Hz-100 kHz at a temperature of 20 degrees C as well
      as with instability of these parameters for 60 min at frequencies of 110, 10(3)
      and 10(4) Hz. Myelin has an extremely high dielectric constant, which might be
      due to the presence of water and a macromolecular structure. The result of the
      measurements are of interest when comparing and adding some details to the data
      of the microelectrode studies.

PMID- 1021912
TI  - [Serotonin formation in the hypothalamus of thyroidectomized rats under the
      influence of exogenous somatotropin].
AB  - The content of serotonin in hypothalamus of thyroidectomized rats is twice as low
      on the 5th day and twice as high on the 14th day after the operation as in the
      intact animals. Specific radioactivity of serotonin after subarachnoid
      administration of tryptophan-14C an hour before killing is twice as high on the
      5th day and twice as low on the 14th day. Exogenous somatotropin prevents from
      the mentioned changes on the 5th day. A conclusion is drawn that the changes in
      serotonin metabolism in the hypothalamus of rats after thyroidectomy is mainly
      determined by the changes in the level of somatotropin in the organism.

PMID- 1021913
TI  - [Modification of the carboxyl and amine groups of the cellulolytic enzymes of
      Aspergillus awamori].
AB  - The activity and stability of some enzymes of Asp. awamori cellulolytic complex
      were studied as affected by chemical modification of carboxylic groups with N,N'
      dicyclohexyl carbodiimide (DCCD) and amine groups with glutaric aldehyde. The
      carboxylic groups are established to be necessary for manifestation of the
      activities of C1- and C2-cellulases, Cx-exo- and Cx-endoglucanases. Their role is
      negligible in the action of beta-glucosidase. The activity of individual
      cellulases was studied as affected by nucleophilic substitution of DCCD-activated
      COOH-groups by various reagents (glycine amide, leucine amide, tyrosine amide and
      N-benzoyl-l-arginine-methyl ether-hydrochloride). Tyrosine amide is the least
      inacting reagent for all the enzymes, glycine amide is somewhat more activating.
      Essential differences are shown in the chemical and catalytic properties of Cx
      exoglucanase and beta-glucosidase. It is found (under the effect of glutaric
      aldehyde) that amino groups are significant for manifestation of the activities
      of C1- and C2-cellulases and Cx-endoglucanase and to a less extent for that of Cs
      exoglucanase and beta-glucosidase. It is supposed that electrostatic interactions
      of the carbolytic and amine groups might be an essential factor for stability of
      C1- and C2-cellulases and Cx-endoglucanase.

PMID- 1021914
TI  - [Sterol content of rabbit erythrocyte membranes normally and in atherosclerosis].
AB  - The sterol composition of erythrocyte membranes was studied in norm and under
      experimental atherosclerosis. It is shown that in the normal animals the content
      of cholesterol in the membranes increases with age and practically reaches a
      relatively constant value by 5-6 months. In the experimental animals being on the
      atherogenic diet the amount of cholesterol in the membranes a month later is
      practically identical to the control. 5-6 months after the experiment the content
      of cholesterol in the membranes decreases as compared to the norm by 38 and 65%,
      respectively. On the basis of the IR- and UV-spectra one may suppose that with
      atherosclerosis in the C27-sterol fraction besides cholesterol, there appears
      sterol containing C=O-group, the mutual orientation of which relative to the
      neighbouring functional group is different as compared in the norm. The deepest
      changes in the qualitative composition of erythrocyte membranes is observed 5-6
      months later when there appears some products of cholesterol or its precursor
      transformation. Such a modification of the sterol composition causes a change in
      the membrane permeability.

PMID- 1021915
TI  - [Content of the nonsaponifying substances in crystalline fructosediphosphate
      aldolase from the muscles of rabbits normally and in atherosclerosis].
AB  - The non-saponifying fraction was found in highly purified crystalline
      preparations of fructose diphosphate aldolase (EC 4.1.2.13). The amount of the
      non-saponifying substance in the aldolase of intact animals is different and
      depends not only on the degree of the enzyme purification. In the experiments
      when the non-saponifying residue was added to the incubation mixture it was found
      to produce no effect on the aldolase activity with the presence of fructose-1,6
      diphosphate and fructose-1-phosphate. A decrease is observed in the activity of
      the crystalline preparations during their storage for four months which depends
      directly on the amount of the non-saponifying fraction in these preparations. The
      amount of the non-saponifying fraction in equally purified preparations of
      aldolase with experimental atherosclerosis is twice as low as compared to the
      norm. The non-saponifying residues of the fructose-diphosphate aldolase muscular
      preparations in the norm and with experimental atherosclerosis consist of two
      components, one of them being cholesterol, the chemical nature of the other
      component is not the same in the norm and with atherosclerosis.

PMID- 1021916
TI  - [Oxidative free radical processes and bioantioxidants during viral
      carcinogenesis].
AB  - The changes in biochemiluminescence intensity of tissue homogenates, tissue
      lipids as well as the values of the antioxidative activity of the free-radical
      processes regulators, bioantioxidants of lipids, and their antiradical activity
      were studied in viral carcinogenesis induced by Moloney's oncornavirus. Kinetics
      of biochemiluminescence of muscles homogenates and muscular tissue tumours
      (Moloney's sarcoma) and that of chemiluminescence of total lipids extracted from
      the muscular and tumour tissue were studied as well. A sharp increase in the
      intensity of lipids biochemiluminiscence and decrease in the tissue homogenates
      biochemiluminiscence were observed during the period of progressive tumour growth
      on the 6-8 days following introduction of the virus. At the same time the values
      of the antioxidative activity and antiradical activity of the tissue lipids
      bioantioxidants were minimal. Results of this investigation suggest that the
      expenditure of bioantioxidants are rather active during the period of progressive
      tumour growth. The regularities of the changes in biochemiluminescence intensity
      in the muscle tissue homogenates with viral carcinogenesis cannot be explained
      exceptionally by an increase in the amount of bioantioxidants in the tumour
      tissue lipids. Evidently the peculiarities of lipid-protein interactions might
      play an essential role in the mentioned process.

PMID- 1021917
TI  - [Changes in the primary structure of rabbit muscle aldolase under the influence
      of valine against a background of prolonged fasting].
AB  - The primary structure of the muscle aldolase molecule was studied as affected by
      semilethal doses of valine administered the abdominal cavity of the rabbits after
      a long fasting. It is established that in spite of differences in the amino acid
      composition of the protein, uniformity of the peptides distribution in the
      process of bromo-cyanogen fragments elution and the total amount of amino acid
      residues in the identical fragments are maintained. Changes are found only in the
      point-replacements by amino acids in C-fragment of the molecule (asparagine is
      replaced by valine and threonine by serine).

PMID- 1021918
TI  - [Electrofocusing of immunoglobulin G that reacts positively in the sedimentation
      reaction for cancer].
AB  - Immunoglobulin G from the serum of patients with myeloma and positively reacting
      in the sedimentary test for cancer (PPR-STC) was purified by DEAE-Spehadex A-50
      and KM-cellulose chromotography and studied by the method of isoelectrofocusing;
      Application of 1% ampholine within the pH gradient 3.0-10.0 shows the difference
      between the isoelectric spectra of immunoglobulin G from the donor and from a
      patient with myeloma. The PPR-STC isoelectric point located in the zone of pH 8.4
      is determined. No subfraction with pH 8.4 is observed in the fraction of the
      donor immunoglobulin G.

PMID- 1021919
TI  - [Intensity of carbon dioxide fixation in the tissues of carp depending on the
      environmental temperature].
AB  - According to the level of carbon dioxide fixation at the incubation temperature
      at 20 degrees C the organs under study are arranged as follows: liver, kidneys,
      glandular system of gills, spleen, myocardium, gastrointestinal tract, skeletal
      muscles. 20 degrees C is the most optimal temperature for the processes of
      carboxylation in the fish.

PMID- 1021920
TI  - [Hydrolysis of insoluble bone collagen by crystalline alpha-amylase from
      Aspergillus oryzae].
AB  - The paper deals with hydrolysis of bone collagen thrice recrystallized alpha
      amylase. The enzyme action was estimated by the amount of released glycopeptides,
      free carbohydrates, alpha-amine groups and total nitrogen in the soluble part of
      the hydrolyzate. The protease admixture in the alpha-amylase preparation was
      found by means of the Aspergillus oryzae protease. The data obtained testify to
      the fact that hydrolysis of collagen under the effect of crystalline alpha
      amylase occurs only due to the protease admixture in the amylolitic preparation.
      When an attempt was made to obtain acid-soluble collagen from bone insoluble
      collagen previously treated with the alpha-amylase preparation, it was found that
      under these conditions bone collagen, as distinct from skin collagen, is not
      solubilized in diluted acetic acid.

PMID- 1021921
TI  - [Separation of adenohypophysis hormones by electrophoresis on a dodecyl sulfate
      polyacrylamide gel].
AB  - Zones of somatotropin, prolactin and subunits of adenohypophysis glycoproteid
      hormones are identified in dodecyl sulphate-polyacrylamide gel after
      electrophoretic separation of these hormones in the tris-acetate system; The
      method is suitable for a quantitative determination of somatotropin and prolactin
      in adenohypophysis.

PMID- 1021923
TI  - [Experimental study of the uveo-scleral outflow of aqueous humor].

PMID- 1021922
TI  - [Tonographic index "H"].

PMID- 1021924
TI  - [Relation between compensation of glaucomatous process and geomagnetic storms].

PMID- 1021925
TI  - [Dilatation of the suprachoroidal space in combination with cyclodialysis].

PMID- 1021926
TI  - [Clinical results of a 1-stage cataract extraction with trabeculectomy].

PMID- 1021928
TI  - [Iridoplasty in cataract microsurgery].

PMID- 1021927
TI  - [Combined operation: trabeculectomy and cataract extraction].

PMID- 1021929
TI  - [Functional morphological parameters of aphakia in rabbits].

PMID- 1021930
TI  - [Significance of heredity in congenital glaucoma].

PMID- 1021931
TI  - [Echographic study of the ciliary body and choroid detachment following
      antiglaucomatous operations].

PMID- 1021932
TI  - [Penetrating prosthetics of the cornea in burn leukomas].

PMID- 1021933
TI  - [Microsurgery of vitreocorneal adhesions].

PMID- 1021934
TI  - [Use of biologically inert metals for artificial eye lens bases (experimental
      study)].

PMID- 1021935
TI  - [Possibilities offered by application of vitreophage in ophthalmosurgery].

PMID- 1021936
TI  - [Papain medication of hemophthalmos].

PMID- 1021937
TI  - [Electrophysiological findings in congested disk of optical nerves].

PMID- 1021938
TI  - [Role of serotonin in mechanism of hydrocortisone action in uveitis].

PMID- 1021939
TI  - [Microcrystallo-optic method of study of the human and animal vitreous body in
      normal and hemophthalmic eye].

PMID- 1021940
TI  - [Organization of work aimed at an early detection of glaucoma in families of
      glaucomatous patients].

PMID- 1021941
TI  - [Effect of sanatorium health resort treatment of the eye condition following
      glaucomatous operations].

PMID- 1021942
TI  - [Questions concerned with tonographic procedures].

PMID- 1021943
TI  - [Graded diascleral translumination as a method for determining functional
      integrity of the retina].

PMID- 1021944
TI  - [Ultrasound and radioactive phosphorus in diagnosis of intraocular pathological
      processes with opacification of the optical eye media].

PMID- 1021945
TI  - [Orthoclinostatic rheo-ophthalmographic test].

PMID- 1021946
TI  - [Use of correction test for determining visual performance capacity in persons
      engaged in doing work involving precision operations].

PMID- 1021947
TI  - [Toward a high standard of production].

PMID- 1021948
TI  - [All-Union School of Young Scientists and Specialists].

PMID- 1021949
TI  - [Veterinary laboratories of Buryatia].

PMID- 1021950
TI  - [Let us satisfy more completely the demand for zootechnical veterinary goods].

PMID- 1021951
TI  - [Mycological characteristics of mixed feeds for poultry].

PMID- 1021953
TI  - [Let us improve the planning of epizootic control measures].

PMID- 1021952
TI  - [Sanitary and bacteriological state of sewage].

PMID- 1021954
TI  - [Effect of Bacillus microorganism on Listeria].

PMID- 1021955
TI  - [Follicular conjunctivitis of chlamdyial etiology].

PMID- 1021956
TI  - [Detection of Vibrio coli in swine].

PMID- 1021957
TI  - [Prevention of fungal diseases in poultry].

PMID- 1021958
TI  - [Prevention of toxicoses during hexachloroparaxylol worming].

PMID- 1021959
TI  - [From every cow a calf].

PMID- 1021960
TI  - [Eimeria tenella resistance to coccidiovit].

PMID- 1021961
TI  - [Treatment of chicks with toxoplasmosis and coccidiosis].

PMID- 1021962
TI  - [Prevention of symptomatic sterility in cows].

PMID- 1021963
TI  - [Treatment of cows with ovarian cysts].

PMID- 1021964
TI  - [Latent metabolic disorders in cows].

PMID- 1021965
TI  - [Treatment of calves with dyspepsia].

PMID- 1021966
TI  - [Pathogenesis of the spasm in osteodystrophy].

PMID- 1021967
TI  - [Effect of ascorbic acid on the growth and safe keeping of chicks].

PMID- 1021968
TI  - [Some physical blood indices of healthy marals].

PMID- 1021969
TI  - [Pathogenesis of alimentary osteodystrophy].

PMID- 1021970
TI  - [Meat and slaughter product expertise in viral diseases].

PMID- 1021971
TI  - [Characteristics of the expert evaluation on carcasses for the detection of
      cysticerci].

PMID- 1021972
TI  - [Effect of trace elements in the ration on pork quality].

PMID- 1021973
TI  - [Characteristics of the laboratory diagnosis of avian-type tuberculosis].

PMID- 1021974
TI  - [Determination of the toxicity of forage grain and the order of its use].

PMID- 1021975
TI  - [Nature of the tyrosine metabolic disorder in systemic lupus erythematosus].

PMID- 1021976
TI  - [Lesion of the craniovertebral area in ankylosing spondylarthritis (Bechterew's
      disease)].

PMID- 1021977
TI  - [Causes of death in rheumatoid arthritis].

PMID- 1021978
TI  - [Diagnosis of podagric arthritis].

PMID- 1021979
TI  - [Long-term family studies in rheumatoid arthritis].

PMID- 1021980
TI  - [Clinical enzymological characteristics of a protracted (torpid) variant of
      rheumocarditis].

PMID- 1021981
TI  - [Microbiological and serological characteristics of odontogenic infection in
      various forms of collagen diseases].

PMID- 1021982
TI  - [Organization by stages of the treatment of children with rheumatism coming under
      dispensary observation].

PMID- 1021983
TI  - [Methodological and scientific aspects of the concept of the pathogenesis of
      rheumocarditis].

PMID- 1021984
TI  - [Pathogenetic bases of rheumocarditis].

PMID- 1021985
TI  - [New aspects of the pathogenesis of rheumocarditis].

PMID- 1021986
TI  - [Effect of rations with a varying content of polyunsaturated fatty acids and
      vitamins on the state of the small intestine in respect of age].
AB  - Groups of young sexually mature and old albino rats were kept for three months on
      4 isocaloric rations, viz. balanced, with reduced proportion of essential fatty
      acids or group 'B' vitamins and with simultaneous curtailment of fatty acids and
      vitamins. With vitamin deficiency there was a certain derangement in the
      structure and function of the small intestine, especially in older animals. A
      shortage of essential fatty acids impaired the condition of the small intestine
      only in old animals. In cases of concurrent deficiency of vitamins and essential
      fatty acids maximal changes in both young and old animals were in evidence.

PMID- 1021987
TI  - [Concept of labile protein and the adaptation of nitrogen metabolism in protein
      deficiency in man].
AB  - Investigations involving 30 healthy males, who for 45 days consumed standard
      semisynthetic diets differing in the caseine content (from 0 to 15.1 g of
      nitrogen per day) and serving as a sole source of protein, furnished data on the
      nitrogen excretion kinetics and nitrogen balance. Mathematical analysis of these
      data allowed it to find the existence of general regularity in the nitrogen
      excretion and to deduce an integral equation of its losses at different levels of
      nitrogen consumption. Pertinent calculations have ascertained that by the labile
      protein one should understand not the specific proportion of the total protein in
      the organism, but the actual rate of its metabolism, manifesting itself in the
      routine lag-phase during adaptation of the nitrogen metabolism to a new level of
      the protein allowances in the organism. The data thus made available permitted
      it, at the same time, to propose a criterion for estimating the optimal
      requirements of man in proteins.

PMID- 1021988
TI  - [Effect of the feeding frequency on protein metabolism in the skeletal muscles
      and liver of white rats].
AB  - A comparative investigation into the influence of 3 and 5 times a day feeding on
      the protein metabolism in the skeletal muscles and liver of albino rats was
      carried out. The dietary regimen with a greater frequency of feeding was found to
      be consonant with a higher concentration of total aminonitrogen and with a number
      of essential amino acids, as well as with a higer activity of asparate
      aminotransferase in the study tissues. Along with this, there occurs a more
      intensive incorporation of radioactive leucine in the total proteins and basic
      proteinic fractions of the skeletal muscles and also augments specific
      radioactivity of the poly-A-containing informative RNA in polysomes and is in
      evidence shifting the ribosomal spectrum toward formation of polysomal complexes.
      The activation of proteinosynthesis observed with increasing frequency of feeding
      may be ascribed to a more uniform diurnal supply of nutrients to the organism.

PMID- 1021989
TI  - [Effect of a glutamate and glutamine excess on the nucleic acid content of the
      spleen cell nuclei in rats].
AB  - In tests conducted with albino rats subject to investigation was the effect of
      sodium glutamate, or glutamine, daily introduced into the stomach in doses of 300
      and 150 mg/kg, on the nucleic acids content in the splenic cell nuclei. All the
      animals taken in the experiment demonstrated a clearcut quantity of nucleonic
      RNA. By using a maximum dose of sodium glutamate and minimal one of glutamine a
      rise in the amount of DNA occurs in the nuclei of the splenic cells.

PMID- 1021990
TI  - [Comparative biological value of low-protein diets with individual amino acid
      supplements].
AB  - The biological value of low-protein rations was distinctly increased following
      their enrichment in lysine, methionine, cystine, sodium and potassium glutamate,
      both individually and in a mixture. The additves under study helped mitigate
      destruction of the bone marrow cells and stabilize factors reflecting the
      immunobiological reactivity for the organism.

PMID- 1021991
TI  - [Distribution of 14C-nicotinic acid in the organs of white rats with a prolonged
      protein and choline deficit].
AB  - In animals receiving for 12 months a ration deficiency of protein and choline
      distribution of 14C-nicotinic acid among their organs was determined. In the
      distribution 14C-nicotinic acid in the organs of the control and test groups of
      the animals no difference was in evidence.

PMID- 1021992
TI  - [Protective action of sulfur-containing compounds in acrylonitrile poisoning].
AB  - Experiments staged on rats evidenced that from among sulfur-containing amino
      acids (methionine, cystine and cysteine) and sodium thiosulfate it was cysteine
      that displayed a pronounced prophylactic and therapeutic effect in acute mortal
      poisonings with acrylic acid nitrile.

PMID- 1021993
TI  - [Effect of qualitatively varying nutrition on the histological structure of the
      liver of pregnant rats in experimental toxic hepatitis].
AB  - The effect of rations with differing proportions of protein, 20, 25, 30 and 40
      per cent in calorific value, and group B vitamins on the structure of the liver
      was studied in 40 pregnant rats with experimental affection of the liver and in
      10 control animals. Histological and electron microscopic investigations were
      conducted. Diets containing 25 and 30 per cent protein and a double amount of
      group B vitamins were noted to help restore the structure of the hepatic tissue
      in pregnant rats with toxic hepatitis. The diet containing 30 per cent of protein
      produces the optimal normalizing effect.

PMID- 1021994
TI  - [Effect of copper on iron metabolism in the body of gastrogenic anemia patients].
AB  - In 40 patients suffering from gastrogenic anemia subject to study were the iron
      content in the daily ration, iron excretion with feces, as well as the level of
      the serumal iron, the whole blood copper, the number of erythrocytes and the
      blood hemoglobin level both before the treatment and at different stages of the
      therapy, 6 mg of copper per day included in the diet. The iron was determined
      after Henry (1958) and copper after L.N. Lapin (1957). The data obtained indicate
      that following a regular taking of copper there increases the iron retention in
      the organism of the patients, this phenomenon being attended by a falling
      concentration of copper in the whole blood and a rising level of the serumal
      iron, hemoglobin and an increase in the number of erythrocytes in the peripheral
      blood. These data confirm the fact of physiological synergism between copper and
      iron in the organism, including that in the organism of patients with gastrogenic
      anemia.

PMID- 1021995
TI  - [Iron, copper and molybdenum metabolism under different conditions of ultraviolet
      irradiation].
AB  - The paper carries information on the influence exerted by different conditions of
      ultraviolet radiation on the metabolism of copper, molibdenum and iron. The
      results made available showed that prophylactic doses of UV-irradiation (100-400
      microerg/cm2 per day) reduced elimination of copper and iron from the organism;
      made for their mobilization from the repository (liver), led to their higher
      level in hemopoietic and other organs and improved blood formation. The UV
      deficit and UV-excess led to a poorer utilization of copper and iron by the
      organism. Under corresponding climatic conditions it is necessary, therefore, to
      raise the iron and copper content in the diurnal food ration.

PMID- 1021996
TI  - [Vitamin B12 and C accumulation in the organs and tissues of laying hens
      administered ascorbic acid in their diet].
AB  - An addition to the basic ration of laying hens of the white leghorn breed of 0.1
      to 2.0 g of ascorbic acid per 100 g of fodder raised the ascorbic acid content in
      the kidneys, heart and comminuted meat of the test animals. Feeding on ascorbic
      acid contributed to a higher content of the vitamin B12 in comminuted meat and in
      the egg yolk, this bearing evidence to the existance of an interrelation between
      the vitamins B12 and C.

PMID- 1021997
TI  - [Study of the composition of killer whale meat as a source of balanced proteins].
AB  - Investigations have shown the proteins of the Orca meat to consist largely of
      complete water-salt and alkaline-soluble fractions and of an insignificant amount
      of connective-tissue proteins. The proteins of the Orca meat contain all the
      amino acids, including essential ones. The lysine and histidine content there in
      is 1.5 times as high in the proteins of beef. The completeness of the amino acids
      composition of Orca meat proteins enables it to utilize this raw material for
      obtaining valuable food products in the form of concentrates or hydrolysates.

PMID- 1021998
TI  - [Change in the sugar content in oaten products, buckwheat and rice groats during
      their heat processing by cooking].
AB  - The sugar content in the grits and in a gruel cooked with samples of oats and
      buckwheat subjected to hydrothermal treatment under different conditions and also
      in the oat flour, a product of baby and dietetic nutrition, was quantified.
      Hydrothermal processing results in significant changes occurring individual
      sugars of the grit. During culinary treatment these changes are levelled out, but
      in the end the level of virtually all types of sugar is higher in the gruel
      cooked with hydrothermally treated grit than in that prepared with initial,
      untreated grit. The oats flour is distinguished by a high glucose, maltose,
      fructose and saccharose content. A fall of the reducing sugars level coming as a
      result of thermal and culinary treatment is explained by their participating in
      the reaction of melanoidine formation. On the other hand, a rise in their content
      under rigorous conditions and in the production of oat flour is due to the
      starting of the starch hydrolysis.

PMID- 1021999
TI  - [Fatty acid makeup of the fat of reindeer].

PMID- 1022000
TI  - [Fatty acid makeup of the butter produced in the Ukraine].

PMID- 1022001
TI  - [Study of the lipid properties of meat treated with infrared rays].

PMID- 1022002
TI  - [Effect of various fat products on the bile makeup and blood level of
      cholesterol].
AB  - In test conducted on rats kept for 60 days on a complete standard ration that
      included one of the fat varieties (sunflower, cotton oils, butter, mutton fat,
      margarine) a hypocholesterolemic effect of the diet with sunflower oil was
      recorded, which was attended by an increased excretion of bile acids and
      cholesterol in the bile. With the rats fed on a low-protein or fat-rich rations
      that included sunflower oil (30 and 60 per cent, respectively) a marked change in
      the ratio between the bile acids and cholesterol, in favour of the latter, was
      noted.

PMID- 1022003
TI  - [Nucleic acid content in beef subproducts].

PMID- 1022004
TI  - [Problems in clinical diagnosis of allergic diseases].

PMID- 1022005
TI  - [Tables for rapid calculation of main rheoencephalographic parameters].

PMID- 1022006
TI  - [Phase structure of the left ventricle systole in patients with arteriosclerosis
      obliterans].

PMID- 1022007
TI  - [Effectiveness of treatment of patients with rheumatoid polyarthritis at the
      balneologic resort Siniak].

PMID- 1022008
TI  - [Case of cure of complete atrioventricular block in rheumatic myocarditis].

PMID- 1022009
TI  - [Long term follow-up and treatment of Wegener's granulomatosis].

PMID- 1022010
TI  - [Hemodynamic indices in persons exposed to ethylated benzine].

PMID- 1022011
TI  - [Experience with lasers of low intensity radiation in the treatment of nervous
      system diseases].

PMID- 1022012
TI  - [Effect of some agents on indices of radiohepatograms using Au-198 in patients
      with chronic alcoholism].

PMID- 1022013
TI  - [Unithiol treatment in patients with fluorosis].

PMID- 1022014
TI  - [Physiological and hygienic evaluation of working conditions of electrocar
      drivers].

PMID- 1022015
TI  - [Characteristics of assimilation of protein paste "Ocean" by the body].

PMID- 1022016
TI  - [Effect of small doses of UHF electromagnetic waves on some indices of renal
      function and water-salt metabolism].

PMID- 1022017
TI  - [Study of prekallikrein-kallikrein system of blood plasma in viral hepatitis].

PMID- 1022018
TI  - [Viral hepatitis and problem of cholestasis in the pregnancy].

PMID- 1022019
TI  - [Clinical aspects of serum hepatitis].

PMID- 1022020
TI  - [Hepato-renal form of leptospirosis].

PMID- 1022021
TI  - [Familial incidents of meningococcal infection].

PMID- 1022022
TI  - [Experience of improving work organization in public health].

PMID- 1022023
TI  - [Indirect test of degranulation of basophils in diagnosis of allergy in viral
      hepatitis].

PMID- 1022024
TI  - [Diagnosis of allergic myocarditis].

PMID- 1022025
TI  - [State of the sympathico-adrenal system in patients with pre-asthma conditions].

PMID- 1022026
TI  - [Dynamics of metalloproteins and blood protein fractions in the course of
      treatment of patients with acute pneumonias].

PMID- 1022027
TI  - [Content of some biogenically active substances in blood of patients with acute
      pneumonias].

PMID- 1022028
TI  - [Present problems of allergology in USSR].

PMID- 1022029
TI  - [Long-term presence of metalic splinter in the lung tissue].

PMID- 1022030
TI  - [Course and remote results of treatment of siderosilicotuberculosis].

PMID- 1022031
TI  - [Bacteriological characteristics of caverns and surrounding pulmonary tissue in
      patients with pulmonary tuberkulosis].

PMID- 1022032
TI  - [Inapperceptive pulmonary tuberculosis and practical ways of its diagnosis in
      rural conditions].

PMID- 1022033
TI  - [Classification of glomerulonephritis and perspectives of its improvement].

PMID- 1022034
TI  - [Mineral composition and structure of primary and recurring renal and ureteral
      calculi].

PMID- 1022035
TI  - [Prophylactic treatment of patients with ulcer in rural conditions].

PMID- 1022036
TI  - [Use of protein substitute therapy in correction of protein aminoacid
      disturbances in patients with stenosing ulcer].

PMID- 1022037
TI  - [Therapeutic effectiveness of pequocrin in chronic cholecystitis].

PMID- 1022038
TI  - [Diagnosis of splenic abscess].

PMID- 1022039
TI  - [Aminoacid balance in thyrotoxic goiter].

PMID- 1022040
TI  - [Aminoacid composition of the blood serum in patients with toxic goiter].

PMID- 1022041
TI  - [Indices of lipid metabolism in thyroid gland function disorders].

PMID- 1022042
TI  - [State of blood coagulation in patients with collagenosis].

PMID- 1022043
TI  - [Immunological data in myocardial infarct complicated by acute circulatory
      failure and cardiac ventricular fibrillation].

PMID- 1022045
TI  - [State of collateral cardiac circulation in hypertensive disease].

PMID- 1022044
TI  - [Activity of blood plasma renin and angiotensin in patients with hypertensive
      disease].

PMID- 1022046
TI  - [Urinary excretion of vanillyl-mandelic acid in hypertensive patients with
      circulatory disturbances].

PMID- 1022047
TI  - [Pulmonary blood filling and tone of the pulmonary artery branches in patients
      with initial stages of hypertensive disease in conditions of physical loading].

PMID- 1022048
TI  - [Age-related changes of regional cerebral blood flow].

PMID- 1022049
TI  - [Clinical aspects and treatment of allergic conditions in focal infections].

PMID- 1022050
TI  - [Treatment of cerebral infarction in patients with hypertensive disease].

PMID- 1022051
TI  - [Experience in treatment of autonomic vascular dystonia with tissue drug EMEKS].

PMID- 1022052
TI  - [Use of autogenic training in combination with acupuncture for treatment in
      patients with autonomic vascular dystonia in ambulatory conditions].

PMID- 1022054
TI  - [Problems in rehabilitation education].

PMID- 1022053
TI  - [Rehabilitation in People's Republic of Poland].

PMID- 1022055
TI  - [30 years of care of the handicapped in Czechoslovakia].

PMID- 1022056
TI  - [Rehabilitation of handicapped in Halle (Saale)].

PMID- 1022057
TI  - [Socio-hygienic aspects of intensification of psychiatric care].

PMID- 1022058
TI  - [Some problems of integration of elderly people in society].

PMID- 1022059
TI  - [Connecting theory and practice in socio-hygienic education - care of retired
      people in Leipzig, Halle-Neustadt and Halle].

PMID- 1022060
TI  - [Social security of elderly in Czechoslovakia].

PMID- 1022061
TI  - [Vocational training and integration of students with impaired vision].

PMID- 1022062
TI  - [Repeated evaluation of fitness and examination of handicapped].

PMID- 1022064
TI  - [Fitness evaluation and training].

PMID- 1022063
TI  - [Evaluation of residual performance capacity in persons of developmental age in
      Poland].

PMID- 1022065
TI  - [Rehabilitation of so-called congenital hip dislocation with special reference to
      Dega's transiliac pelvic osteotomy].

PMID- 1022066
TI  - [Observations on patients of psychiatric rehabilitation center - results of 3
      year follow-up study after patient discharge].

PMID- 1022067
TI  - [Psychiatric rehabilitation - principles].

PMID- 1022069
TI  - On the role of the electron microscope in the identification of lysosomes.

PMID- 1022068
TI  - [Antioxidant system of the cell and carcinogenesis].

PMID- 1022070
TI  - [Lysosomes and leucodystrophies].

PMID- 1022071
TI  - [Lysosomes in connective tissue diseases (author's transl)].

PMID- 1022072
TI  - [Demonstration of intra- and extracellular lysosomes in the hemodynamically
      stressed arterial wall of the rat].

PMID- 1022073
TI  - [Lysosomes in blood cells as diagnostic parameter (author's transl)].

PMID- 1022074
TI  - [Lysosomes and antiinfectious resistance (author's transl)].

PMID- 1022075
TI  - [The compromised host secondary to lysosomal deficiencies (author's transl)].

PMID- 1022076
TI  - [Experimental investigation on the influence of simple and polymerizated stroma
      free hemoglobin solutions on the morphology of liver and kidney in the rat
      (author's transl)].

PMID- 1022077
TI  - [Morphological and functional studies on hemoglobin degradation in renal tubules
      damaged by ischemia (author's transl)].

PMID- 1022078
TI  - [Lysosomal origin of a brown pigment in the renal tubules of wistar-rats with a
      spontaneous nephropathy (author's transl)].

PMID- 1022079
TI  - [TSH stimulation and cytochemical activity of lysosomal enzymes of the thyroid. A
      microdensitometric study (author's transl)].

PMID- 1022080
TI  - [Electron microscopic analysis of lysosomes in human thyroid tumours (author's
      transl)].

PMID- 1022081
TI  - [Lysosomes in pituitary adenomas: structures and value for the estimation of
      endocrine activity (author's transl)].

PMID- 1022082
TI  - [Lysosomes in experimental storage dystrophy due to chronic chloroquine
      intoxication (author's transl)].

PMID- 1022083
TI  - [Inhibition of glucagon-induced autophagy by cycloheximide. Quantitative
      examinations on rat hepatocytes (author's transl)].

PMID- 1022084
TI  - [Effects of thyroid hormones on the activities of lysosomal peptidehydrolases
      (author's transl)].

PMID- 1022085
TI  - [The problem of the effect of thyroxin in the lysosomal breakdown of cell
      organelles in liver cells (author's transl)].

PMID- 1022086
TI  - [Disseminated lipogranulomatosis (Farber). Case report of the 16th case of a
      ceramidose (author's transl)].

PMID- 1022087
TI  - [A morphological and biochemical study in Niemann-Pick disease (author's
      transl)].

PMID- 1022088
TI  - [Adult Niemann-Pick disease (author's transl)].

PMID- 1022089
TI  - [Morphologic, clinical and biochemical findings in Mucolipidosis II (author's
      transl)].

PMID- 1022090
TI  - [The problems of residual body variability in diseases of the nervous system
      (author's transl)].

PMID- 1022091
TI  - [The ultrastructure of reactive astroglia in the brain of newborn children
      (author's transl)].

PMID- 1022092
TI  - [Lysosomes and autophagy (author's transl)].

PMID- 1022093
TI  - [Osteocytic and osteoclastic bone resorption. Comparative ultrastructural studies
      in rat after stimulation by parathormone (author's transl)].

PMID- 1022094
TI  - [The lysosomal system of osteoclasts in primary hyperparathyroidism - an
      electronmicroscopic investigation in human bone biopsies (author's transl)].

PMID- 1022095
TI  - [On the possible role of lysosomes in the reproduction processes of the
      myocardium mitochondria (author's transl)].

PMID- 1022096
TI  - [Renal tubules in experimental malacoplakia: phagocytic activity of proximal
      tubular epithelium (author's transl)].

PMID- 1022097
TI  - [The activity of lysosomal hydrolases in the axillary lymphnodes by breast
      carcinoma (author's transl)].

PMID- 1022098
TI  - [Therepeutic effect of an angiotensin II antagonist in experimental malignant
      nephrosclerosis].

PMID- 1022099
TI  - [Physiologic and pathologic dissolution of tissue in the endometrium and at the
      site of placentation (author's transl)].

PMID- 1022100
TI  - [Morphologically demonstrable bases of a) normal menstruation and its
      disturbances b) nidation c) detachment of the placenta during birth].

PMID- 1022101
TI  - [Clinical aspects of hemorrhagic disorders (author's transl)].

PMID- 1022102
TI  - [Circulatory lesions of the human placenta in abruptio (author's transl)].

PMID- 1022103
TI  - [Pathology of placenta accreta (author's transl)].

PMID- 1022104
TI  - [Clinical aspects of premature detachment of the placenta, placenta accreta and
      placenta increta (author's transl)].

PMID- 1022105
TI  - [Lysosomes and pigments (author's transl)].

PMID- 1022106
TI  - [Lysosomes and heterophagy (author's transl)].

PMID- 1022107
TI  - [Lysosomes during ontogenesis (author's transl)].

PMID- 1022108
TI  - [Lymphoblastic transformation test as an index of the state of immunological
      reactivity in alopecia].

PMID- 1022109
TI  - [Histochemical study of the nonspecific esterases, lipase and cholinesterase in
      normal human skin].

PMID- 1022110
TI  - [Fibrinolytic components in healthy skin].

PMID- 1022111
TI  - [Role of the blood cells in specific allergic reactions in Trichophyton rubrum
      infection].

PMID- 1022112
TI  - [Biologically active substances of the blood and the blood coagulation system in
      eczema].

PMID- 1022113
TI  - [Case of primary systemic amyloidosis].

PMID- 1022114
TI  - [So-called Ota's nevus].

PMID- 1022115
TI  - [Some problems of the clinical aspects and course of disseminated
      neurodermatitis].

PMID- 1022116
TI  - [Local and general toxic action of parsnips].

PMID- 1022117
TI  - [Hereditary universal atrichia].

PMID- 1022118
TI  - [State of the peripheral blood and bone marrow in porphyria cutanea tarda].

PMID- 1022119
TI  - [2 cases of late syphilis in 1 family].

PMID- 1022120
TI  - [Thyroid hormone in the early development of the CNS. Effect of hyperthyrosis on
      the proliferative activity of the external granular layer of rat cerebellum].

PMID- 1022121
TI  - Studies on lipolytic system of human placenta, blood lipids and lipid mobilizing
      activity in pregnant women and newborns.
AB  - Lipolytic activity of human placenta and lipid mobilizing activity (LMA), free
      fatty acids (FFA) as well as esterified fatty acid (EFA) levels in serum of
      pregnant women in different periods of pregnancy and in newborn's serum were
      studied. Lipolytic activity of human placenta is low in the first trimester of
      pregnancy and increases in samples examined after delivery. The levels of FFA and
      EFA in blood of pregnant women are significantly increased in the second and
      third trimester of pregnancy. The newborn's blood lipid level is significantly
      lower than that in the mother's blood. Lipid mobilizing activity in serum of
      pregnant women increases especially in the third trimester of pregnancy and is
      also high in newborn's blood. This may indicate that fatty acids released from
      newborn's adipose tissue are metabolized as a source of energy.

PMID- 1022122
TI  - Lipid mobilizing activity in the blood of obese patients during prolonged
      fasting.
AB  - Lipid mobilizing activity is lowered in the serum of obese patients. During short
      term fasting, this activity increases in non-obese subjects. The present study
      was concerned with the changes in lipid mobilizing activity in the blood of obese
      patients during prolonged fasting, and with the behavior of esterified and free
      fatty acids. Serum levels of free fatty acids in the control subjects were
      significantly lower than in the obese women. During a 14-day period of complete
      fasting, levels of free fatty acids increased in all cases. In non-obese subjects
      this was accompanied by a significant rise in lipid mobilizing acitivity, but in
      obese subjects no significant change took place in this activity. The findings
      indicate that high levels of free fatty acids in obese persons during fasting are
      caused by inhibition of their esterification.

PMID- 1022123
TI  - Blast transformation induced by spermatozoa.
AB  - Human lymphocytes cultured for 3-8 days in the presence of autologous or
      allogenic spermatozoa undergo blast transformation. Possible mechanisms of the
      response are discussed.

PMID- 1022124
TI  - Circular dichroism studies on DNA condensed in NaCl cetyltrimethyl ammonium
      bromide solutions.
AB  - It is shown by means of circular dichroism studies of variously condensed forms
      of DNA that the specific supramolecular structure of DNA determines the type of
      CD spectra. DNA, condensed (crystallized) slowly in the presence of
      cetyltrimethyl ammonium bromide yields a spectrum very similar to that of DNA in
      solution in the B-form. The condensates appear in the phase-contrast microscope
      as spherulitic crystallites. Rapidly condensed DNA in the presence of
      cetyltrimethyl ammonium bromide shows a spectrum of the psi-type with large
      negative ellipticites. The influence of condensation velocity upon the
      supramolecular structure of DNA gives evidence that the various condensation
      forms of DNA are not thermodynamical equilibrium conformations.

PMID- 1022125
TI  - [Determination of the rate of microthrombosis in experimentally induced
      disseminated intravascular coagulation (DIC)].
AB  - A procedure is described for the determination of the rate of microthrombosis in
      rats. It is based on the quantitative estimation of I125-fibrin deposits by
      measurement of the accumulated radioactivity in the organs after substitution of
      blood.

PMID- 1022126
TI  - Studies on the loss of sensitivity in smooth muscle.
AB  - Specificity of desensitization effect was investigated at guinea pig ileum using
      the desensitizing agonists acetylcholine, carbachol, histamine, and serotonine.
      The desensitization with acetylcholine markedly diminished the contraction
      effects to test doses of all tested agonists. Contrary to acetylcholine, the
      histamine desensitization is mainly specific, the serotonine desensitization is a
      complete specific effect. A different influence of the tested agonists on
      intracellular ions is discussed.

PMID- 1022127
TI  - Influence of prostaglandins upon adenosine release and of adenosine upon
      prostaglandin release in the isolated rabbit heart.
AB  - Prostaglandin (PG) E1 with its high effect of coronary dilation causes a distinct
      increase in the adenosine release from the isolated rabbit heart (Langendorff
      technique). Compared to this, an equal dose of PGF2alpha increases the release of
      adenosine only to a small extent. Conversely, application of adenosine results in
      a considerable release of PG-like substances from the rabbit heart in vitro. The
      present investigations support the hypothesis that, apart from adenosine, PG's
      too, are involved in coronary regulation as modulators.

PMID- 1022128
TI  - Proteins of animal ribosomes. XXV. Proteins of rat liver ribosomes protected by
      polyuridylic acid from methyl acetimidate substitution.
AB  - Addition of poly(U) to complexes of 40S and 60S subunits of rat liver ribosomes
      decreases the substitution of amino groups of 12 proteins of the small ribosomal
      subunit and of 11 proteins of the large subunit by [14C]-methyl acetimidate. When
      comparing the results obtained with this amino group specific reagent with the
      reactivity of the proteins against iodoacetamide it becomes obvious that 4
      proteins of the small ribosomal subunit (S12, 18, 19, 24) and 3 proteins of the
      large one (L20, 22, 25) are partially protected by poly(U) against reaction with
      both reagents.

PMID- 1022129
TI  - [Kinetic properties of enzymes in particular of yeast alcohol dehydrogenase
      following their adsorption on polyaminomethylstyrene].
AB  - The adsorption of 8 enzymes to polyaminomethylstyrene was studied. While lactate
      dehydrogenase, alkaline phosphatase and glucose-6-phosphate dehydrogenase exhibit
      a relatively low affinity to the carrier, alcohol dehydrogenase, glutamate
      dehydrogenase and urease were found to form stabile complexes with the polymer
      that are enzymatically active. Adsorbed urease and beta-hydroxybutyrate
      dehydrogenase, are still active after several weeks; the other preparations lose
      their activity soon. It can be shown by the example of yeast alcohol
      dehydrogenase that the activity loss following adsorption is caused possibly by a
      process of reorientation of already bound enzyme molecules or by the increasing
      enzyme coverage of the carrier, with the active centres becoming more and more
      inaccessible for the substrate. During the substrate conversion catalysed by the
      alcohol dehydrogenase-polyaminomethylstyrene complex, a small amount of the
      enzyme is again detached from the carrier. The activity rises to a certain extent
      in the supernatant but drops to zero again. The stability of the adsorbed urease
      is distinctly increased compared with the dissolved enzyme. For the pH optimum
      and the KM value there are no differences between the two preparations.
      Continuous application of polyaminomethylstyrene-bound beta-hydroxybutyrate
      dehydrogenase and urease, respectively, in a column shows that both preparations
      have unchanged enzymatic activities even after running times of 5 and 24 days,
      respectively.

PMID- 1022130
TI  - Kinetics of elementary steps in the cytochrome P-450 reaction sequence. I.
      Substrate binding to cytochrome P-450 LM.
AB  - The substrate binding step in the reaction sequence of the cytochrome P-450
      enzyme system (rat liver microsomes) has been investigated. The type I/II
      substrate classification kinetically holds too. The rate constants are in the
      10(3) to 10(5) (M-1 sec-1) range, the type I compounds are preferably bound by
      about one order of magnitude. The rate constants of the binding process to the
      reduced cytochrome are considerably decreased. The results favour the ordered
      reaction mechanism.

PMID- 1022131
TI  - [Cellular test for RNA-synthesis in rat bone marrow and its use in testing
      cryoprotective and toxic agents].
AB  - A system for the measurement of the RNA-synthesis of bone marrow cells of the rat
      has been developed and the incorporation of [3H]-uridine into the cellular RNA
      has been standardized with respect to the time of incubation, the concentration
      of [3H]-uridine and the number of cells. A plateau of the incorporation of [3H]
      uridine into the RNA is reached after 20 min of incubation and is interpreted as
      the expression of a steady state in synthesis and degradation of the cellular
      RNA. A constant labelling of the RNA is reached above 8.3 with 10(-6)M [3H]
      uridine. The optimal cell number in the 500 mul standard assay is 4 with 10(6).
      Actinomycin D inhibits the RNA-synthesis to 94% in a concentration of 1.2 with
      10(2) mug/ml. The cryoprotectants dimethylsulfoxide, polyethylene-oxide and
      glycerol and the potential haematotoxic substances
      dichlorodiphenyltrichloroethane and gamma-hexane were tested in this system. 5%
      dimethylsulfoxide and 10% polyethylen-oxide in Eagle's-medium with
      ethylendiamintetra-acetate do not influence the RNA-synthesis. 5% glycerol
      reduces the incorporation of [3H]-uridine into the cellular RNA to about 30%.

PMID- 1022132
TI  - [Membrane effect of potassium rhodanide and methotrexate].
AB  - In HeLa cells and macrophages rhodanide ions cause biological hyperpolarization
      of the cell membranes, while methotrexate hyperpolarizes the membranes as an
      antimetabolite. Cell physiologically, rhodanide has a general stimulating effect
      within the physiological control range of the cell. This membrane effect could be
      related to the physiological and therapeutic action of rhodanide in processes
      involving immunological events.

PMID- 1022133
TI  - Lymphokines which influence electrophoretic mobility of macrophages.
AB  - Supernatants of blood lymphocytes from immunized guinea pigs after incubation
      with purified protein derivative (PPD) were fractionated on Sephadex G-75. The
      fractions were tested for activity to change the electrophoretic mobility of
      macrophages. Dependent on incubation time, three different regions of activity
      with an average molecular weight of 13 000, 40 000 and more than 100 000 were
      estimated.

PMID- 1022134
TI  - [Simple dynamic model of the human blood pressure regulatory system as based on
      the orthostatic load sequence].
AB  - The two statistical parameter estimation methods, the recursive least squares and
      the recursive generalized least squares, are dealt with briefly. An additional
      noncorrelated disturbance is necessary for unbiased parameter estimation in the
      closed-loop system. The disturbance is realized by an orthostatic load sequence
      shaped according to the experimental programme. Men and women were subjected to
      head-up tilt between 10 degrees and 55 degrees. The disturbance, mean blood
      pressure and heart rate were measured. These discrete data were used for
      parameter estimation of transfer functions.

PMID- 1022135
TI  - Lithium accumulation in some endocrine tissues.
AB  - Lithium levels were measured in several tissues of rats after oral lithium
      administration for various periods of time. The lithium levels in the brain
      approached those of the serum while there was a marked accumulation of lithium in
      the pituitary and thyroid glands. When lithium was stopped there was no
      noticeable lag in clearance for any of the tissues examined, with the pituitary
      maintaining a significant elevation of lithium over the serum levels. Animals
      receiving lithium had higher levels of adrenal corticosterone under quiescent
      conditions and higher levels of plasma corticosterone thirty minutes after a
      brief electric footshock.

PMID- 1022136
TI  - [Influence of prenatal malnutrition on later body-weight gain in guinea pigs].
AB  - In prenatally underfed guinea pigs the following data were obtained: 1. On the
      1st day of life the mean body weight of 18 underfed animals was significantly
      reduced as compared to that of 18 control animals. This difference was not
      compensated by postnatal feeding ad libitum but persisted up to the 36th week of
      life (day of sacrificing). 2. The mean food intake per day estimated over 10 days
      during the 5th month of life was also significantly diminished in the prenatally
      underfed animals. 3. A significant positive correlation was found between the
      body weight at birth and the adult body weight, adult body length and adult body
      weight/body length, when the parameters of the experimental plus control animals
      were evaluated together. These findings suggest that in guinea pigs, which are
      born in a relatively mature stage, the prenatal nutrition can influence body
      weight, body length and body weight/body length ratio as well as food intake in
      adulthood.

PMID- 1022137
TI  - [Effect of anoxia on energy supply and isotonic work performance in the
      myocardium of the frog].
AB  - To investigate correlations between energy supply and mechanical work in the
      frog's myocardium in true anoxia, the stroke volume, systolic and diastolic
      volumes and the parameters of velocity of contraction and relaxation of frog
      hearts were compared to the levels of high energy phosphates and the delivery of
      lactate. During perfusion with N2 saturated Ringer solution, stroke volume,
      systolic contractility and diastolic relaxation decrease till a contracture. High
      preload produces a dilatation growing up to the contracture after retarded and
      weakened relaxation. The ATP-content decreases during the first quarter of the
      experiment to 60%. CP decreases continuously to 15%, ADP and AMP remain constant.
      There is a production of lactate increasing considerably with the onset of
      contracture. The measured glycolysis is not sufficient for production of
      mechanical work. The effect of anoxia on the action potential and the reduction
      of the sequestration of Ca++ and of the break of actomyosin bridges following the
      decrease of ATP are considered as causing the series of the mechanical events.

PMID- 1022138
TI  - Serum glycoproteins level and urinary glycosaminoglycans excretion in drug
      induced collagen-like syndrome in guinea pigs.
AB  - A collagen-like syndrome was produced by a long-term administration of 1
      hydrazinophthalazine (hydralazine) to guinea pigs. The results obtained indicate
      that hydralazine-induced collagen-like syndrome stimulated an increase of the
      concentration of perchloric acid-soluble proteins, protein-bound hexoses, protein
      bound-hexosamines and sialic acids in blood serum as well as urinary excretion of
      glycosaminoglycans. The increase of serum glycoproteins is not connected with non
      specific changes in total protein level. No biochemical differences were found in
      the parameters studied between subgroups (LE-positive and LE-negative) of
      hydralazine treated animals.

PMID- 1022139
TI  - Antioxidants as agents potentiating the antiinflammatory action of indomethacin.
AB  - Nordihydroguaiaretic acid inhibits prostaglandin (PG) biosynthesis in vitro
      (ID50=228 muM), with a slope of dose-response curve high (b=209) as compared with
      indomethacin (ID50=0.1 muM, b=72.1). Butylated hydroxyanisole, in contrast to
      inactive butylated hydroxytoluene, inhibits PG biosynthesis (ID50=107 muM, b=63).
      Only norihydroguaiaretic acid (100 mug, s.p.) inhibited the postcarrageenin edema
      of rat paw. Butylated hydroxyanisole (10 mug, s.p.) given together with a
      subthreshold (1 mug) dose of indomethacin inhibited the paw edema by 35%, while
      butylated hydroxytoluene and nordihydroguaiaretic acid produced a similar effect
      only when given at 10-fold higher doses. The results suggest the possibility of
      potentiation and prolongation of the anti-inflammatory effect of indomethacin by
      its simultaneous administration with an antioxidant, butylated hydroxyanisole.

PMID- 1022140
TI  - [Studies on the specificity of an antiserum against denaturated DNA from Sarcina
      maxima].
AB  - An antiserum against denatured DNA from Sarcina maxima (71% (A + T)) reacted in
      complement fixation tests with denatured DNA's of various sources. The
      serological activity of the antibodies is in correlation with the (adenine +
      thymine)-content of the DNA's used as antigens. Haptene inhibition tests
      demonstrate a preferable reaction of the antibodies with T2-sequences. The
      heterogeneity of DNA-antisera and the increasing specificity of such antisera, if
      DNA with high (A + T) or (G + C)-content served as immunogen, are discussed.

PMID- 1022141
TI  - The immune response of brown trout (Salmo trutta L.) to injection with soluble
      antigens.
AB  - The immune response of brown trout (Salmo trutta) to horse serum and keyhole
      limpet haemocyanin was studied. Intraperitoneal and intramuscular injections were
      used, with and without adjuvant, in 209 fish. Complement-fixing antibodies (CFA)
      and precipitins were produced to both antigens. CFA were detected after 8 days to
      haemocyanin and after 13 days to horse serum. Maximum CFA titres to a single
      intraperitoneal injection of horse serum or haemocyanin were reached at 44 and 43
      46 days respectively. Precipitins to a single injection of haemocyanin given
      intraperitoneally were detected after 19 days using gel diffusion. Similarly
      using the intramuscular route they were detected after 22 days. However, using
      counter-current electrophoresis, precipitins were detected after 8 days by the
      intraperitoneal route and after 9 days by the intramuscular. Precipitins to horse
      serum given intraperitoneally were demonstrated after 22 days by both gel
      diffusion and counter-current electrophoresis. Fish given 2 intraperitoneal
      injections of haemocyanin in adjuvant reached maximum CFA titres after 55 days; a
      3rd injection on day 56 did not produce a marked increase in titre. Fish given
      intramuscular injections of haemocyanin in adjuvant showed maximum CFA titres at
      day 43. After a 3rd injection on day 56, maximum CFA titres were reached between
      days 92 and 106. Intramuscular injections gave significantly higher titres than
      those given by the intraperitoneal route. Some fish which showed no precipitins
      by gel diffusion were positive by counter-current electrophoresis. Precipitating
      antibodies to haemocyanin migrating in the beta2-gamma1 region were detected by
      immuno-electrophoresis.

PMID- 1022142
TI  - [Program for the computation of concentrations of free metabolites, metal ions
      and their complexes in chemical balance].
AB  - Enzymic reaction velocities often depend primarily on the concentrations of
      single free and complexed species rather than on the total metal and metabolite
      concentrations. For determining single species concentrations from total
      concentrations and complex stability constants, a program is described. The
      program may not only calculate the single concentrations, but also estimate their
      uncertainty due to the unavoidable uncertainty of complex stability constants.
      Making use of the ICT 1900 magnetic drum storage, it may deal with quite large
      complex patterns as are found in vivo.

PMID- 1022143
TI  - Inhibition studies on the interaction of Vicia faba lectin with carbohydrates.
AB  - Mono- and oligosaccharides and modified sugars have been studied quantitatively
      for their capacity to inhibit the agglutination reaction between Vicia faba
      lectin and yeast cells. The results seem to parallel the specificity of
      carbohydrate binding reported for concanavalin A.

PMID- 1022144
TI  - [Main tasks of the health services of the CSR after the 15th congress of the
      Czechoslovak party (author's transl)].

PMID- 1022145
TI  - Our procedure for examination of patients with scoliosis (author's transl).

PMID- 1022146
TI  - [Screening of scoliosis in infants and their follow-up for eleven years (author's
      transl)].

PMID- 1022147
TI  - [Effect of asymmetric length of the lower extremities on changes of the curvature
      of the spine (author's transl)].

PMID- 1022148
TI  - [Results of treatment of congenital hip dysplasia since birth (author's transl)].

PMID- 1022149
TI  - [Treatment in stages of congenital equinovarus deformity of the foot].

PMID- 1022150
TI  - [Contribution to the treatment of supracondylar fractures of the humerus in
      children (author's transl)].

PMID- 1022151
TI  - [Osteosynthesis of pertrochanteric fractures by means of bent elastic splints
      according to Simon-Weidner-Ender].

PMID- 1022152
TI  - [Results and complications of therapy for femoral fractures (author's transl)].

PMID- 1022153
TI  - HMO: new frontier for rehabilitation medicine perseonnel.

PMID- 1022154
TI  - Field dependence-independence and injury in college football players.

PMID- 1022155
TI  - A temporary B/K PTB prosthesis with a porous socket.

PMID- 1022156
TI  - Improvising a bicycle for clinic use in hospitals.

PMID- 1022157
TI  - Academic achievement, personality, and behavior in emotionally disturbed
      children.

PMID- 1022158
TI  - The independent college of pharmacy in the future development of pharmaceutical
      education.

PMID- 1022159
TI  - Pharmacy practice--the importance of effective communications.

PMID- 1022160
TI  - Some psychodynamic aspects of the seduction of patients in psychotherapy.

PMID- 1022161
TI  - The psychoanalyst: an agent of the social milieu.

PMID- 1022162
TI  - Inauthenticity, flight from freedom, despair.

PMID- 1022163
TI  - Latency: fact or fiction?

PMID- 1022164
TI  - Linguistic dimensions in the bilingual patient.

PMID- 1022165
TI  - Innovation in preventive psychotherapy with children.

PMID- 1022166
TI  - Functions of denial fantasy.

PMID- 1022167
TI  - [Skeletal growth and maturation of the elbow. Kinetic study (author's transl)].

PMID- 1022168
TI  - [A tomographic study on the cervico-occipital articulation during rheumatoid
      arthritis. Remarks on 50 cases (author's transl)].

PMID- 1022169
TI  - [Benign indeterminate cystic images of the upper and of the femur in the
      adolescent and adult (author's transl)].

PMID- 1022170
TI  - [Radiological and surgical comparisons in the study of the biliary tract.
      Cholangiography by one-hour perfusions. Peroperative cholangiography (author's
      transl)].

PMID- 1022171
TI  - [Esophageal localization of Darier's disease. Radiological description. With
      reference to 4 cases (author's transl)].

PMID- 1022172
TI  - [The value of total body opacification in the diagnosis of abdominal cystic
      lymphangiomas in children (Description of a new radiological sign: the "cloison"
      sign) (author's transl)].

PMID- 1022173
TI  - [Value of the uro-angiographic water-soluble iodinated contrast media in the
      radiological examination of the colon in children. Report of 50 examinations
      (author's transl)].

PMID- 1022174
TI  - [Radiographic diagnostic difficulties of primary and secondary bone tumors in
      children (author's transl)].

PMID- 1022175
TI  - [Three cases of non-atheromatous dissection of the renal artery (author's
      transl)].

PMID- 1022176
TI  - [Use of the axillary route to study the abdominal aorta and arterial branches of
      the lower limbs (author's transl)].

PMID- 1022177
TI  - [A direct radiological sign of meningioma of the anterior angle of the chiasma:
      "pneumosinus dilatans" (author's transl)].

PMID- 1022178
TI  - [Radiological manifestations of pus collections in the pelvis (author's transl)].

PMID- 1022179
TI  - [Three new so-called contact laxatives (author's transl)].

PMID- 1022180
TI  - Diuretic action of estradiol.
AB  - Several clinical situations are strongly suggestive that estrogens are diuretic
      substances that secondarily promote sodium and water retention in the body by
      stimulation of adreno-cortical hormone secretion. To investigate the direct
      action of estradiol on diuresis, the hormone was administered to the isolated,
      perfused rabbit kidney. Results demonstrated that estradiol increases urine
      volume, tubular sodium excretion and potassium reabsorption, and diminishes
      arterial pressure and renovascular resistance. The possible relationships between
      these effects and with pre-menstrual syndrome, pre-eclampsia, and menopausal
      hypertension are discussed.

PMID- 1022181
TI  - [Influence of reduced pterine and juvenile hormone on the pigmentation of the
      phasms Carausius morosus (author's transl)].
AB  - Tetrahydrofolic acid and dimethyltetrahydropterine, FH4 and DMH4P, have an
      antagonist action. FH4 darkens the phasms. DMH4P and the tryptophane have an
      inhibitrice influence on the melanisation, probably by the increase of the
      synthesis or the release of serotonin, in the hypoderm. For the adult phasm
      remaining ivory, xanthopterin must be added in the treatment. The addition of
      diapausing chrysalids pieridae extract (containing juvenile hormone JH) and
      treated by FH4, in the treatment precedent, transmits the pgimentary effect at
      the first generation, which presents a strong percentage of dark or ivory phasms.

PMID- 1022182
TI  - [Effect of SRIF (somatostatin) on human somatroptropic adenomas in vitro
      ultrastructure and growth hormone production (author's transl)(proceedings)].

PMID- 1022183
TI  - [Effects of cadmium chloride on the hypophyso-testicular axis of the golden
      hamster a study of the atenhypophysis with immunofluorescence technique (author's
      transl)(proceedings)].

PMID- 1022184
TI  - [Ultrastructural evidence of two types of neurosecretory axons and nerve-endings
      in the posthypophysis of the garden dormouse (Eliomys quercinus) (author's
      transl)(proceedings)].

PMID- 1022185
TI  - [Cellular localization of somatostatin (author's transl)(proceedings)].

PMID- 1022186
TI  - [Pituitary LH micro-adenoma. A new pathological entity? (author's
      transl)(proceedings)].

PMID- 1022187
TI  - [Evaluation of hypothalamo-pituitary-gonadal axis in women treated by
      haemodialysis (author's transl)(proceedings)].

PMID- 1022188
TI  - [Radioimmunoassay for vasopressin : plasma levels after stimulation by I-V
      nicotine injection (author's transl)(proceedings)].

PMID- 1022189
TI  - [Neuroendocrine investigation and therapy of the menstrual cycle disorders
      (author's transl)(proceedings)].

PMID- 1022190
TI  - [Identification of a new neuro-endocrine syndrome "hyperponderosis with dewaking
      state". 1. Electropolygraphic study (author's transl)(proceedings)].

PMID- 1022191
TI  - [Inadequate corpus luteum function in benign breast-diseases (author's
      transl)(proceedings)].

PMID- 1022192
TI  - [Endemic goiter at Oloron Sainte Marie (author's transl)(proceedings)].

PMID- 1022193
TI  - [Analysis of urodynamic disorders in the urethral pressure, bladder pressure and
      miction profile. Methods, normal values as well as diagnosis and course of
      observations of urologic diseases].

PMID- 1022194
TI  - [Study of the correlation between 2 tests on a subjects adaptation to work in a
      automobile assembly factory (Volkswagen Brussels)].

PMID- 1022195
TI  - [Alcohol and traffic: official detection of drunken drivers, the top of the
      iceberg].

PMID- 1022196
TI  - [Medico-legal interest in sudden or rapid deaths].

PMID- 1022197
TI  - [Signs of puberty, body built and physical performance in primary school
      children].

PMID- 1022198
TI  - [Pancreatic ascites. Report of 14 cases (author's transl)].

PMID- 1022199
TI  - [Ultrasonic appearances in acute pancreatitis. Study of 49 patients examined in
      real time and with grey scale (author's transl)].

PMID- 1022200
TI  - [Folate deficiency after digestive surgery. An experience based on 50 cases
      (author's transl)].

PMID- 1022201
TI  - [Pancreatic functional exploration by duodenal tubage after ceruleine and
      secretinic stimulation (author's transl)].

PMID- 1022202
TI  - [Mechanical complications and obstetrical risks of intestinal by-pass in obesity
      (author's transl)].

PMID- 1022203
TI  - [Unintentional gastro-ileostomy].

PMID- 1022204
TI  - Depression of respiratory muscles and defective responses to nasal obstruction
      during active sleep in the newborn.

PMID- 1022205
TI  - Lobar atelectasis after nasotracheal intubation in newborn infants.

PMID- 1022206
TI  - The height and weight changes of Melbourne children compared with other
      population groups.

PMID- 1022207
TI  - Growth and development of fat in adolescent school children in Cictoria. Part 1.
      Normal growth values and prevalence of obesity.

PMID- 1022208
TI  - Growth and development of fat in adolescent school children in Victoria. Part 2.
      Influence of ethnic, geographic and socio-economic factors.

PMID- 1022209
TI  - Selection of patients by ultrasonic echography for fetal and immediate neonatal
      surgery.

PMID- 1022210
TI  - The radiological follow-up of aboriginal children with bronchiectasis treated
      surgically or medically.

PMID- 1022211
TI  - Scintigraphic diagnosis of Meckel's diverticulum.

PMID- 1022212
TI  - The treatment of encopresis using behaviour modification.

PMID- 1022213
TI  - Drug interaction in psoriasis.

PMID- 1022214
TI  - Immunological studies on Behcet disease.

PMID- 1022215
TI  - Hutchinson's melanotic freckle: partial regression of lesion and surrounding
      actinic keratoses.

PMID- 1022216
TI  - Vitamin E treatment of epidermolysis bullosa acquisita.

PMID- 1022217
TI  - Insulin secretion and glucose tolerance in granuloma annulare.

PMID- 1022218
TI  - The relationship between ultraviolet light sensitization and tar exposure of the
      skin.

PMID- 1022219
TI  - The mongoloid spot.

PMID- 1022220
TI  - The rarity of solar keratoses in psoriatic patients preliminary report.

PMID- 1022221
TI  - Morphometric and autoradiographic investigation of the small and large intestinal
      mucosa of rats with chronic experimental renal insufficiency.
AB  - Following a previous study with experimental short-term, high-grade uremia the
      changes of the small and large intestinal mucosa of rats with surgically induced
      chronic renal insufficiency were analysed. A clear tendency to inhibition of the
      rate of the physiological cell regeneration by prolongation of the mitotic cycle
      in correlation to the degree of renal insufficiency could be demonstrated. There
      was a extension of the generation time up to 40% in ileum and up to 50% in the
      large intestine in the animal group with the relatively highest degree of renal
      insufficiency. This extension was mainly due to a prolongation of the postmitotic
      Gi-phase. At the same time the total number of crypt epithelia and of the
      regenerative cells in the enlarged crypts increased. The enlargement of the
      regenerative crypt population is interpreted as an adaptive compensation of the
      inhibition of the cell production by prolongation of the mitotic cycle. A damage
      of the differentiated surface epithelium could not be detected. The significance
      of the present results and their relationship to so-called uremic entero-colitis
      and to sprue-like changes of small intestinal mucosa in man is discussed.

PMID- 1022222
TI  - Effects of lymph diversion versus corticosteroids on blood and lymphocyte pools.
AB  - Thoracic duct-rumen fistulae (TDRF) and low or high doses of Prednisolone were
      employed to induce depletion of blood and lymph node lymphocytes in calves.
      Elimination of the easily mobilizable pool of lymphocytes was almost complete
      within 6 days after commencing TDRF. Blood lymphocyte counts were reduced to
      approximately 1/3 of pre-TDRF levels. Prednisolone in low doses did not decrease
      the number of blood lymphocytes. High doses of Prednisolone induced a moderate,
      progressive blood lymphocytopenia. Both TDRF and low and high dose Prednisolone
      schedules induced a significant reduction of lymphocytes in lymph nodes. The loss
      of small lymphocytes from lymph nodes was almost entirely restricted to the
      diffuse cortical (paracortical) zone. The lymphocyte counts in the follicular
      cortex and in the medulla were not significantly affected. Almost complete
      disappearance of germinal centers was observed in lymph nodes of calves subjected
      to TDRF or high doses of Prednisolone.

PMID- 1022223
TI  - [DNA Turnover in the Whole Body of Tumour Bearing Mice (author's transl)].
AB  - During the last 3 decades several authors have found in tumour-bearing animals an
      increase of synthesis and content of DNA in various organs which were free from
      neoplastic cells (Griffin, 1957;Kelly and Jones, 1950; Morgan and Cameron, 1973;
      Cerecedo et al., 1951; Lombardo et al., 1952). 5-iodo-2'-deoxyuridine (IUdR) is a
      thymidine analogue and specifically incorporated into DNA. When it is labelled
      with 125I or 131I it permits to reinvestigate these findings by measuring the
      rate of precursor incorporation into DNA and the rate of loss of labelled DNA in
      the living animal by means of counting the gamma emission from the incorporated
      iodine isotopes. In this paper, therefore, an attempt is made to analyse the DNA
      turnover in the whole body of liver tumour-bearing mice. MATERIAL AND METHODS: 5
      iodo-2'-deoxyuridine (IUdR) labelled with 125iodine was used as DNA precursor. It
      is a thymidine analogue 5% of which is specifically incorporated into the DNA of
      those proliferating cells which are in the phase of DNA synthesis at the moment
      of tracer application. Non-incorporated IUdR (about 95% of the injected amount)
      is rapidly degraded and excreted within 24 hours. The tracer remains bound to the
      cellular DNA druing the life span of the labelled cells. After cell death only
      about 5% of IUdR from DNA breakdown is reutilized. 125I has a half live of 60
      days and therefore allows, over periods of weeks, external measurements of the
      DNA turnover in the living animal without disturbing the physiological
      environment. The measured loss of DNA-bound 125I reflects almost exclusively the
      turnover of the labelled cells. Female albino NMRI mice, 2 months old, bearing
      sarcoma-180 implanted into the right hind leg were intraveneously injected with 2
      muCi 125I-UdR. At the time of injection, the tumour had reached in one group of
      mice an average volume of about 25 mm3 and in another group an average volume of
      nearly 850 mm3. When implanted into subcutaneous tissue sarcoma-180 rarely
      produces metastases in parenchymal organs, never in the spleen and--within the
      first 30 days after implantation--only in ca. 10% of the animals a small
      metastasis in a single lymphnode (Deodhar and Crile, 1969; Franchi et al., 1968).
      Whole body measurements were carried out immediately after tracer injection and
      then daily during the first week and every second or third day in the following 2
      weeks in a NaI well counter with a single channel pulse height analyser. The
      tumour activity was also determined in vivo by a special counting device.
      RESULTS: In the normal mouse 4 to 6% of injected 125I-UdR is retained in the
      whole body 24 hours after tracer injection. During the following five days the
      125I activity rapidly declines to 0.8% of that of day O immediately after
      injection. Thereafter the rate of loss of activity greatly diminishes (Fig. I).
      The first component of the turnover curve reflects an average daily cell loss of
      approximately 30% and involves about 90% of the incorporated activity...

PMID- 1022224
TI  - Granuloma inguinale simulating advanced pelvic cancer.
AB  - This paper describes a case of multiple disease in an Aboriginal woman. Granuloma
      inguinale, of unusual severity and extent, which closely simulated advanced
      pelvic malignant disease, was included. Some problems of the diagnosis are
      discussed.

PMID- 1022225
TI  - Enhance anchorage independence and tumorigenicity of aneuploid Chinese hamster
      cells with nearly doubled chromosome complements.
AB  - The role of a cell's chromosome complement in its tumorigenic and anchorage
      independent growth properties in vitro was investigated by injecting a Chinese
      hamster cell line and its subclones into immunodeficient nude mice and by plating
      the cells in a semisolid medium containing methylcellulose. The parental WOR-6
      cell clone originally consisted of 89% 1s cells and 11% cells with a nearly
      double (2s) complement. Tumors that developed from WOR-6 were found to consis
      entirely or primarily of cells with near 2s chromosome complements. Subclones of
      WOR-6 that contained only 1s cells rarely produced tumors in nude mice, even at
      high inoculum doses, whereas clones containing a high fraction of 2s cells were
      consistently tumorigenition, serial passage of WOR-6 cells in semisolid medium
      resulted in selective enrichment for near 2s cells and, concomitantly, greatly
      enhanced tumorigenicity. Analyses of G-banded chromosomes revealed that the 1s
      cells of the WOR-6 parental clone, which has a modal chromosome number of 21 and
      a range of 18 to 23, is completely or partially monosomic for some chromosomes
      and trisomic for others. The 2s cells, selected both in vivo through growth as
      tumors in nude mice and in vitro in semisolid medium, appeared to have resulted
      from preferential duplication of certain chromosomes of the 1s cells. Our results
      therefore suggest that cells which develop multiple copies of selected genes,
      while remaining functionally hemizygous for other loci, acquire an enhanced
      anchorage-independent growth potential in vitro and increased tumorigenicity.
      This conclusion is consistent with the observation that cellular tumorigenicity
      is correlated with anchorage independence (Rreedman and Shin, 1974) and leads
      support to OHNO'S (1974) suggesting that aneuploidy is a possible means employed
      by cells to express recessive phenotypes and increase their tumorigenicity.

PMID- 1022226
TI  - Prenatal exposure and carcinogenesis.

PMID- 1022228
TI  - Biologic determinants of tumor growth in scar tissue.

PMID- 1022227
TI  - An anomalous muscle (accessory subscapularis-teres-latissimus muscle) in the
      axilla penetrating the brachial plexus in man.
AB  - An anomalous muscle passing through the brachial plexus was found in 10 cases out
      of 380 sides of 190 human cadavers in the dissection course. The muscle was
      designated as 'accessory subscapularis-teres-latissimus muscle'. This muscle
      arose near the lateral margin of the scapula, either from the surface of the
      subscapularis muscle or from the border of the quadrangular terminal tendon of
      the latissimus dorsi or from both of those sources when the muscle was divided
      into two heads. It ran obliquely upward to fuse with the insertion of the
      subscapularis. The largest anomaly was 2.5 cm in width and 7 cm in length. This
      muscle could be classified into three types on the basis of its nerve supply and
      its relation to the brachial plexus. The type I muscle crossed over the axillary
      and lower subscapular nerves, behind the radial nerve and was innervated by the
      lower subscapular nerves. The type II musclepenetrated the brachial plexus
      separating the radial nerve into two roots; the upper from the posterior division
      of the upper trunk and the lower from the posterior divisions of the middle and
      lower trunks. The type II muscle was supplied by a branch of the radial nerve,
      which originated always at the same level as the origin of the thoracodorsal
      nerve. The type III muscle passed through the further more ventrocaudal level of
      the plexus; in one case it divided the radial nerve into an upper root from the
      posterior divisions of the upper and middle trunks and a lower root from the
      lower trunk, and, in another case, into an upper main root from all the three
      trunks and a lower slender root from the lower trunk. The type III muscle was
      supplied by branches from the radial and in addition from the thoracodorsal nerve
      in one case. In four out of ten cases, the subscapular or thoracodorsal artery
      also passed posterior to the anomalous muscle. A discussion was made on the
      nature of the anomalous muscle.

PMID- 1022229
TI  - Successive stereo and vernier position discrimination as a function of dark
      interval duration.

PMID- 1022230
TI  - HLA in maturity-onset diabetes [proceedings].

PMID- 1022231
TI  - HLA antigens in families of juvenile onset diabetics [proceedings].

PMID- 1022232
TI  - [The activities of the general practitioner during office hours. Concept and
      results of an empirical analysis].

PMID- 1022233
TI  - [Models of growth, self-reproduction and autoregulation based on consideration of
      reaction vessels with distensible, semipermeable walls].
AB  - We constructed non-equilibrium thermodynamics of the open physical-chemical
      irreversible processes in reactors with the strain semipermeable walls. This
      thermodynamics does not use the reciprocal relations of Onsager, so it may be
      applied when the stability stationary state is far from equilibrium. One of a
      general consequences of this thermodynamics is the statement: coordinated growth
      and self-reproduction are possible near the absolute equilibrium of the
      dissolvent and near the absolute stability stationary state of all chemicals with
      the absolute conservation of the differential equations of chemical kinetics. The
      supposition of ideal mixing is unnecessary; this condition is fulfilled
      automatically with diffusion. Growth and self-reproduction are not connected with
      positive eigenvalue of the differential equation of chemical kinetics. It is
      possible to construct a model of autoregulation and differentiation with this
      thermodynamics. The uniquness of such autoregulation follows from the
      mathematical theory [1]. The mathematical foundation of this thermodynamics is
      given in [1].

PMID- 1022234
TI  - [Polymer chain with eliminated volume in an exterior field].
AB  - The problem of the behaviour of a polymer chain with excluded volume in an
      external attractive potential field was considered. It was found that the phase
      transition (the capture of a polymer by a potential pit), is the phase transition
      of the second kind; the excluded volume affects neither the temperature, nor the
      kind of phase transition, but it influences essentially the structure of the
      system after capture. An analysis of this structure was undertaken; the
      dependence of the critical temperature on the parameters of the pit was
      calculated.

PMID- 1022235
TI  - [Kinetics of reactions between hemoglobin and carbon monoxide. II. Analysis of
      kinetic schemes in linear approximation].
AB  - The kinetics of hemoglobin (Hb) reactions with carbon monoxide were calculated
      for a number of classical schemes: with one, two, four binding sites and an
      allosteric scheme with T- and R-conformers. The developed theory predicts the
      existence of only one relaxation time for every scheme the values of which
      depends on the velocity constants, saturation degree and the Hb concentration.

PMID- 1022236
TI  - [Estimation of the amount of energy transformed in the actomyosin--ATP system
      according to kinetics findings].
AB  - A kinetic scheme for actomyosin ATPase reaction, including two different states
      of the energy-rich actomyosin intermediate and different ways of its formation
      and decomposition, is considered. The energy, liberated in this reaction, amounts
      to 9 kcal. mol-1. Energy liberation is coupled with myosin head rotation. The
      energy-rich intermediate is stabilized by hindrances to head motion. By this
      mechanism the energy transduction in a filamentous actomyosin system can occur
      only after a dissociation act, and an ordered cyclical reaction can take place.

PMID- 1022237
TI  - [Relationship between temperature and catalase kinetics under conditions of
      substrate inactivation].
AB  - The kinetic behaviour of catalase at substrate inactivation in temperature
      interval 3 degrees - 50 degrees was studied. There is maximum at 25 degrees on
      curve: temperature - rate of reaction. This maximum takes place because of a
      change of the substrate inactivation of catalase with temperature. Dependence of
      the substrate inactivation constant (ko) on temperature was calculated.

PMID- 1022238
TI  - [Stereochemical enhancement of specificity in biological recognition systems].
AB  - Specificity of the reaction of equilibrium association as a model of recognition
      process has been analysed. It has been shown that subdividing the centres of
      recognition into two uncoupled groups may lead to the effect of stereochemical
      enhancement of specificity, i. e. an increase of the fraction of the correct
      complex. If the second group of centers is unspecific, then a compensation of
      mistakes on a specific group of centers by unspecific ones takes place.
      Stereochemical enhancement of specificity requires the presence in the
      recognition protein molecule of a mechanism of switching on - off interaction on
      a group of centers. The most universal method of such switching on - off is a
      conformational transition in the protein molecule and (or) the "substrate".

PMID- 1022239
TI  - [Photo-emissions of nucleic acids and related compounds in the 120--250 nm
      region].
AB  - Photoemission of thin films of uracil, citosine, timine, adenine, quanine, DNA,
      RNA, nucleosides, nucleotides in the spectral region 125-250 nm is investigated.
      Photoemission work functions are determined, their values are in the interval of
      5.7-6.1 ev. The dependence of photoemission efficiency on wave length for uracil,
      timine, DNA, RNA are measured. The results of this work with earlier data on
      luminescence yields are discussed. Possibility of radiation recombination process
      for wave lengths shorter than 160 nm is suggested.

PMID- 1022240
TI  - [Globule--substrate complex: several effects caused by the polymeric nature of
      the globule].
AB  - To anaylse possible role of globule polymeric nature in enzyme functioning, an
      equilibrium complex of homopolymeric liquidlike globule with a hard ball which
      models the substrate is considered. It is shown that the presence of linear
      memory in the globule may lead to an increase of the braking moment of forces
      affecting the substrate, to additional phase transitions concerned with a
      transition of the substrate of the globule centram to the perifery and vice versa
      etc. The shape of the globule surface adsorbed on the substrate is calculated.

PMID- 1022241
TI  - [Spin label study of the structure and conformational properties of fibers from
      cotton grown from gamma-irradiated seeds].
AB  - According to ESR spectra of the radical - probe I it has been shown that there
      are two regions in cotton cellulose: ordered and disordered ones, pointing to
      inhibition and free rotation of the radical. 40 spin-labeled samples of cotton
      filaments and their mutants by the radicals II-IX chemically bound by the
      cellulose hydroxyl group were obtained. From ESR spectra strong inhibition of
      iminoxyl radical was established which was the evidenced of high rigidity of
      disordered regions of cellulose. Conformational changes of cotton cellulose grown
      from seeds exposed to different doses of gamma-irradiation.

PMID- 1022242
TI  - [Ion channels of the tonoplast of Characeae algal cells. Role of calcium ions in
      excitation].

PMID- 1022243
TI  - [Ca ions in regulation of the permeability and mechanical properties of
      intercellular contacts of small intestinal epithelium].
AB  - The role of Ca in regulating passive permeability of alkaline cations is
      investigated. As it has been shown, the pathway of permeability are intercellular
      junctions [9-10]. An attempt was made to use permeability parameters for
      characterizing intercellular junctions. Forms of Ca binding and the nature of
      site, that discriminated ion permeation are evaluated. To develop the studies of
      functional peculiarities of intercellular junctions, the role of Ca in regulating
      the mechanical properties of intercellular junction of small intestine epithelia
      are investigated.

PMID- 1022244
TI  - [I. Role of diffusion in the transport of radioactive substances through the
      skin].

PMID- 1022245
TI  - [Mechanisms of spontaneous relaxation of smooth muscle (guinea pig taenia coli)
      depolarized in a hyperkalemic medium].
AB  - Experiments were performed on isolated strips of guinea pig taenia coli by the
      double sucrose-gap method. The artificial node was depolarized with potassium
      solution (from 120 to 167.7 mM KCl). When the bathing solution contained 0.4 mM
      Ca and the temperature was equal to 25 degrees C then potassium contracture was
      followed by fast relaxation. The muscular tone changed slightly during
      rectangular pulse of hyperpolarizing current, after switching off the current
      muscle generated a transient contractile response. The amplitude of such off
      responses increased in some range with increasing in strength and duration of
      conditioning current. Treatment of muscle with compound D-600 resulted in a
      reduction of muscular tone and elimination of off-responses. The addition of Na
      ions to potassium solution (substitution of 47.7 mM KCl with the same quantity of
      NaCl) reduced muscular tone and enhanced the relaxation after off-responses. In
      sodium-free potassium solution each off-response was followed by increasing
      muscular tone but when the bathing solution contained Na ions this increase of
      the tone was not observed. The data obtained strongly suggest that the
      spontaneous relaxation of smooth muscle which was contracted in K-solution
      resulted from: 1) inactivation of calcium channels of surface membrane, 2)
      sequastration of Ca ions by intracellular storange sites, 3) extrusion of Ca in
      extracellular space (in part by means of Na-Ca exchange diffusion).

PMID- 1022246
TI  - [Mechanisms of change in the tonus of depolarized smooth muscle (guinea pig
      taenia coli) during application of a hyperpolarizing current].
AB  - Using double sucrose-gap technique three types of contractile responses of
      depolarized smooth muscle (guinea-pig taenia-coli) current-induced
      hyperpolarization were investigated: 1) contractions, 2) relaxations and 3)
      biphasic responses (relaxation followed by contraction). Every preparation
      generated generally only one type of responses (of different amplitude) when
      passing the currents of various strength. These responses were attributed to the
      changes of calcium fluxes through the cellular membranes under hyperpolarization.
      The phenomena observed were analysed on the mathematical model. Quantitative
      analysis showed that description of calcium current changes with equations of
      Hogkin-Huxley types was not sufficient; the model predicts the existence of non
      inactivating channels in the smooth muscle cellular membrane. This very
      assumption allows to describe correctly all three types of cintractile responses.

PMID- 1022247
TI  - [Study of the state of the electron-transport chain in the leaves of higher
      plants by the method of rapid fluorescence induction].

PMID- 1022248
TI  - [Dynamics of the measured oxidative potential of preserved blood].
AB  - An expression for oxidative potential (phi) of conservated blood is suggested
      proceeding from the assumption of the steady character of the system
      methemoglobin -- hemoglobin, oxihemoglobin included. This system is suggested to
      be responsible for the formation of phi in the blood. The equation qualitatively
      describes the experimental relation of phi on time at the contact of blood with
      air. Relationship between the changes of oxidative potential in the blood during
      its storage with the state of conservated blood hemoglobin is discussed. The
      experimental data show that measuring of the oxidative potential may be the basis
      for creating a control method for the state of conservated blood during its
      storage.

PMID- 1022249
TI  - [Influence of illumination on thermogenesis of growing cultures of halophilic
      bacteria].
AB  - 1. Formation of purpuric membranes depends on the light spectral composition
      applied for culture illumination. 2. Red light turned to be less favourable for
      the formation of purpuric membranes, the blue one was more favourable for this
      purpose. 3. Thermogenesis of the culture giving the greatest yield of purpuric
      membranes is plotted by the curve with a large number of falls of thermogenesis.
      4. At a decrease of cultivation temperature even under the blue light the
      formation of purpuric membranes is inhibited. 5. The decrease of thermogenesis at
      definite moments of cultivation of halophiles is concerned with the formation of
      purpuric membranes in the cells.

PMID- 1022250
TI  - [Dicrete zones of electrical connection between Purkinje terminals and muscle
      fibers in dog ventricles].
AB  - Activity of Purkinje terminals (P) and neighbouring muscle (M) fibres (P -- M
      pairs) in various regions of dog's right ventricle was recorded. It has been
      shown that transmission of stimulation from P-to M-fibres is abserved not over
      all endocardial surface, rather in descrete sites -- zones of P--M-interaction.
      The zones ellips like with the axes 300X100 micron, they are located relatively
      far from one another -- at the distance of 800-2000 microns. The total area of
      the zones equals 5% of endocardial surface. P-M delay is less within the zone of
      connection of P--M-fibres (4 msec) and greater outside the zone (up to 10 msec).

PMID- 1022251
TI  - [Non-stationary processes in a monomeric excitable medium. II. Influence of
      parameters of an excitable medium on the process of division of an excitation
      front].

PMID- 1022252
TI  - [Theory of the EEG potential in models of the leptomeninges of the brain. IV.
      Radial dipoles and their double layers in the depths and on the surface of the
      brain].
AB  - The estimaiton of ECoG-potentials is fulfilled by means of a simple model of the
      isolated sphere, which is exact enough, as it was proved earlier [1]. A simple
      limit formula for the qualitative estimation of ECoG-potentials of a source
      situated in the cerebral cortex is obtained. The EEG as in [2] is obtained using
      the transformation of the first 20 spheric harmonics. The experimental facts of
      registration of the evoked potentials of comparatively little subcortical sources
      were explained theoretically. Numerical results of the model are used to estimate
      the intensity of the field induced in the brain by two electrodes placed on the
      scalp.

PMID- 1022253
TI  - [Networks of excitable elements. VIII. Methods of approximation of the theory of
      nets].

PMID- 1022254
TI  - [Work of the human visual system. V. Opposite color difference and anticolor. 2d
      series of experiments].

PMID- 1022255
TI  - [Illusion of movement in ocular tracking movements].

PMID- 1022256
TI  - [Direct comparison of the detection characteristics of the binaural analyzer of
      the human auditory system and a detector the correlation method of processing
      signals].
AB  - An experimental comparison of output performances of human binaural system and
      correlation detector has been carried out. These phenomena are developed by
      detection of the tonal signals, masked by narrow-band noise, central at the
      signal frequency (fc) and having half-bandwidth deltafm=0.01 fc. The results are
      obtained with fc=800, 1000, 1500, 2000, 4000 and 6300 Hz. In these conditions the
      human binaural system may be discussed as correlation detector with the
      resolution: deltar=0.02 when fc less than or equal to 500 Hz and deltar=0.08 when
      fc more than or equal to Hz.

PMID- 1022257
TI  - [Relationship between the torsion coefficient and the resolving capacity of
      biopolymer electrophoresis in polyacrylamide gel].

PMID- 1022258
TI  - [Nature of the transverse striations of collagen fibers].

PMID- 1022259
TI  - [Chemoluminescence of preserved bone tissue].
AB  - The luminescence of bone tissue was studied during its treatment at preservation.
      It was found that vacuum drying as well as bone saturation with ascorbic acid and
      some antibiotics (streptomycin, monomycin) depressed the luminescence emission.
      Combined influence of these factors was found to be more difficult than for each
      one separately. The greatest deterioration of chemoluminescence intensity was
      observed during additional treatment with antimetabolite.

PMID- 1022260
TI  - [Contribution of volume charge to nuclear mobility during intracellular
      microelectrophoresis].

PMID- 1022261
TI  - [Infrared spectra of erythrocyte shadows in the region of the amide I and amide
      II bands following microwave irradiation].
AB  - No beta-structures of protein molecules were observed by IR-spectra of intact
      erythrocyte shadows. Ultra high frequency irradiation in the range of 1009 mHz
      intensity of 45 mW/cm3 results in small conformational reconstructions of
      molecules in the membrane, but it does not induce a notable transition of alpha
      helix or coil into beta-structure. A decrease of the intensity of lipid band by
      1740 cm-1 is shown up at the spectra. Deuterium exchange for 36--38 min shows
      that the transition of the band amide II near 1540 cm-1 into the band 1450 cm-1
      proceeds faster under UHF irradiation than in the control. The effects observed
      are in a direct relation-ship with the intensity of UHF-field and disappear at
      the intensities of 5--8 mW/cm3 and lower.

PMID- 1022262
TI  - [Influence of phospholipids on oxidation of the methylester of oleic acid].
AB  - It has been shown on the model of thermic oxidation of oleic acid methyl ether
      that addition of phosphatidylethanolamine and lisophosphatidylcholine into a
      developed reaction brings about some regularities which can be accounted for as
      oxidation of two-substances. It is suggested that phospholipids can be the
      substrate of radical oxidation of substances in oxidative transformations of
      lipids in the cell. In this case according to oxidation conditions the same
      phospholipids can appear either as prooxidants or as antioxidants.

PMID- 1022263
TI  - [Virus associated antigens, keys to knowledge and control of viral hepatitis (A,
      B and others)].

PMID- 1022264
TI  - [Influence of the small bowel motility on its microcirculation (author's
      transl)].

PMID- 1022265
TI  - [The glycolipoproteins of plastid membrane system in process of chloroplast
      biogenesis].
AB  - The glycolipoprotein fractions were isolated from the prolamellar and lamellar
      system of plastids. The glycolipoproteins were studied on the formic acid--urea
      polyacrylamide gel. The glycolipoproteins from the chloroplast lamellar system of
      bean leaves have the molecular weight 38 000, 93 000 and above 160 000. The amino
      acid composition of glycolipoproteins and its biosynthesis were studied in vivo
      and in vitro experiments. The glycolipoproteins were the first membrane proteins
      which were formed by chloroplasts in vitro. It is concluded that 70S ribosomes
      are involved in the glycolipoproteins biosynthesis.

PMID- 1022266
TI  - [A study of heterogeneity of isomerase and epimerase of pentose phosphates from
      rat spleen by electrophoresis in polyacrylamide gel].
AB  - The heterogeneity of isomerase and epimerase of pentose phosphates from rat
      spleen was studied by electrophoresis in polyacrylamide gel. Three
      electrophoretical fractions of the enzymes are demonstrated. The ten-fold
      purification of the isomerase and epimerase by saline fractionation does not
      alter their catalytic properties and electrophoretic pattern.

PMID- 1022267
TI  - [DNA-methylase activities from animal mitochondria and nuclei: different
      specificity of DNA methylation].
AB  - DNA-methylase activities which methylate cytosine residues in homo- and
      heterologous DNA were detected in mitochondria and nuclei from rat liver and beef
      heart. Adenine modifying DNA-methylases in mitochondria and nuclei were not
      found. DNA from mitochondria and nuclei differ significantly in the methylation
      degree and in the pattern of the 5-methyl-cytosine distribution by pyrimidine
      isostichs as DNA in vivo and in vitro being methylated. Mitochondrial DNA
      methylase has the maximum activity at 30 degrees and pH 7.8 this enzyme(s)
      differ(s) from the nuclear one(s) in the pH dependence of its activity. After
      exhaustive in vitro methylation of various DNA by the nuclear enzyme DNA
      methylase from mitochondria additionally introduces CH3 groups from S
      adenosylmethionine into these DNA (about 3 times more CH3 groups than nuclear
      enzyme). Nuclear DNA-methylase also methylates DNA which is previously fully
      methylated by the mitochondrial enzyme, but to a lesser degree. In conditions of
      exhaustive DNA methylation mitochondrial enzyme introduces into E. coli B DNA
      about four times more methyl groups as compared to the nuclear one. After the
      methylation of E. coli B DNA by mitochondrial enzyme the label (3H-methyl) was
      detected predominantly in mono-, and in case of nuclear enzyme--in di- and
      tripyrimidine fragments. Mitochondrial DNA-methylase differs from the nuclear one
      in the nature of recognized DNA sequences; these enzymes seems to be represented
      by different proteins. The mitochondrial enzyme methylates shorter nucleotide
      sequences in DNA as compared to the nuclear DNA-methylase. All these data suggest
      there exist organoid specificity of genome methylation in animal cell and the
      modification-restriction systems in animal nucleus and mitochondria are different
      in character.

PMID- 1022268
TI  - [Plasma membrane proteins of embryo cells of various sea urchin species and
      hybrid embryo].
AB  - Differences are observed in plasma membrane proteins of S. intermedius and S.
      droebachiensis sea urchin embryo cells isolated at middle blastula stage by means
      of acrylamide-gel electrophoresis in presence of SDS, urea or non-ionic
      detergents--Triton X-100 or Brij 35. Electrophoretic mobilities of plasma
      membrane proteins of sea urchin hybrid embryo malemale S. intermedius X
      femalefemale S. droebachiensis were identical with electrophoretic mobilities of
      plasma membrane proteins of maternal species S. droebachiensis. Three sea urchin
      embryo species under study had just the same biosynthesis of plasma membrane
      proteins at middle blastula stage detected by 14C-aminoacids pulse-labeling
      followed by membrane isolation, electrophoresis and gel-autoradiography.

PMID- 1022269
TI  - [Identification of RNAase-sensitive 20S RNA in a cell culture infected with
      Sindbis virus].
AB  - RNAse-sensitive 20S RNA component with molecular weight of 0.7-10(6) is found
      when analysing virus-specific RNAs isolated from cultured chicken embryo
      fibroblasts infected with Sindbis virus by means of gradient centrifugation and
      polyacrylamide gel electrophoresis.

PMID- 1022270
TI  - [Multiplicity of molecular forms and thermostability of Torula thermophila UzPT-1
      protease].
AB  - Alkaline protease preparations with different ratio of molecular forms are
      isolated from cultural medium of thermophilic fungi Torula thermophila UzPT-1 by
      means of protein fractionation with (NJ/)2SO4 and gel filtration through Sephadex
      G-75. The enzyme preparations differ in their thermostability in water at 60
      degrees C. High molecular weight oligomeric enzyme forms dissociate in water (at
      2-4 degrees C) forming dimeric and monomeric forms. Disaggregation is accompanied
      by the change in the thermostability of the enzyme preparations. It is concluded
      that protease thermostability depends on the ratio of dimeric and monomeric forms
      of the preparation, and it is associated with the conformational state of the
      enzyme molecules, and it is associated with the conformational state of the
      enzyme molecules. Oligomeric forms do not dissociate in 1% sodium dodecylsulphate
      and in 6 M urea. Ca2+ produces dissociation of high molecular weight enzyme forms
      and the conformational transition into the thermostable state.

PMID- 1022271
TI  - [Micromethod of ultracentrifugation in cesium chloride].
AB  - The micromethod of ultracentrifugation in cesium chloride is described. Band
      destributions have been analysed by the direct scanning of microtubes with the
      differential doublewave micro-spectrophotometer at 260 nm. The 10(-8)-10(-9) g of
      DNA or ribosomes are enough for one analysis, tube volume is 2 mul. The method
      described permits the simultaneous centrifugation of several probe scores. The
      error of the beyoant density determination is 0.001 g/sm3 relatively internal
      standard. DNA's from 5 types of Acetabularia were analysed by the developed
      technique.

PMID- 1022272
TI  - [Transcription of repeated and unique DNA nucleotide sequences in rat thymus
      cells stimulated with phytohemagglutinin].
AB  - Transcription of unique and repeated DNA sequences in normal and
      phytohemagglutinin (PHA)-stimulated rat thymus cells is studied. It is found that
      heterogenous nuclear RNA (hnRNA) contains the transcript both from unique and
      repeat-d DNA sequences. PHA does not induce re-distribution of hnRNA fractions
      transcripted from different for their recurrency genome regions. Moreover, hnRNA
      from normal thymus cells competes with RNA from stimulated cells within the range
      of COt values (10(-3)-10(-4)) in which the hybridization has been carried out. It
      is concluded that no activation of new genome regions takes place in thymocytes.

PMID- 1022273
TI  - [Primary structure of cyanogen bromide fragments of sei whale (Balaenoptera
      borealis) pituitary somatotropin].
AB  - 5 fragments are isolated after the degradation of somatotropin from sei whale
      pituitary glands with cyanogen bromide: N-terminal 4-segmented; C-terminal 12
      segmented with the internal disulfide bond; middle 25- and 30-segmented and a
      high molecular weight fragment following N-terminal tetrapeptide and bound with
      disulfide bond to 30-segmented fragment. Complete amino acid sequence of three
      shortest cyanogen bromide fragments is deciphered and N- and C-terminal sequence
      is investigated in two large fragments after their uncoupling under performic
      acid oxidation. Amino acid sequence is deciphered of a peptide obtained after
      trypsine hydrolysis of 30-segmented cyanogen bromide fragment. Comparison of
      amino acid sequence of whale somatotropin fragments with that of sheep, beef and
      human somatotropin has revealed that 57 out of 61 identified amino acid residues
      of whale somatotropin repeat amino acid residues in similar regions of beef
      somatotropin, 56--of sheep and only 42--of human somatotropins. Besdies, 4 of 5
      revealed amino acid substitutions in whale hormone, as compared with sheep
      somatotropin, are amino acids which are present at the same positions in human
      hormone.

PMID- 1022274
TI  - [32S Tubulin oligomer. The resistance to factors suppressing the microtubule
      formation].
AB  - The resistance of brain 32S tubulin oligomer to factors suppressing the
      microtubules formation: colchicine, CaCl2, cooling and the absence of GTP is
      studied. The content of oligomer in the preparation and the polymerization degree
      were estimated by means of analytical centrifugation. Colchicine at 25 degrees
      and at a concentration of 10 muM does not change and at a concentration of 100
      muM only slightly decreases the content of oligomer. The oligomer dissociated
      (but not completely) in 1 mM colchicine. Tubulin polymerization was partly
      suppressed by 10 muM and completely--by 100 muM colchicine. CaCl2 at 1 and 10 mM
      concentrations did not destroy the oligomer but inhibited its polymerization even
      in lesser of these concentrations. The cooling of the incubation medium to 14
      degrees C or 4 degrees C completely inhibited the polymerization and did not
      affect the content of oligomer in the preparations. Tbulin preparations with low
      amount of exogenous GTP (less than or equal 3.10(-6) M) had a usual oligomer
      content, whereas GTP is necessary for polymerization at concentrations exceeding
      10(-4) M. Thus, the reaction of tubulin oligomerization is relatively resistant
      to factors preventing the microtubules assembly. This probably means that there
      are at least two types of intereaction between tubulin molecules: 1) bonds in
      microtubules which are sensitive to colchicine, Ca2+ and cold, and which are
      formed only in the presence of nucleosidetriphosphates; 2) bonds in 32S tubulin
      oligomer which are more stable and do not need in exogenous nucleotides.

PMID- 1022275
TI  - [Modification of histidine residues with diethylpyrocarbonate in aspartate
      transaminases from pig and chicken heart cytosol].
AB  - One and three histidine residues react with diethylpyrocarbonate (DEP) at pH 6.5
      in native aspartate transminases from cffect on the enzyme activity. The rest
      histidine residues in aspartate transaminases (approximately 6 in the chicken
      enzyme and 5 in the pig enzyme) are DEP-nonreactive and can be carbetoxylated
      only after protein denaturation. The presence of substrates does not affect the
      histidine modification in transaminases.

PMID- 1022276
TI  - [In vitro incorporation of labelled amino acids into heart muscle ribosomes at
      early and late stages of compensatory heart hyperfunction].
AB  - The activity of a protein-synthesizing cell-free system from heart muscle was
      studied at early and late stages of compensatory heart hyperfunction. It was
      found that the incorporation of amino acids into heart ribosomes during 48 hours
      after the hyperfunction had been produced, increased by 30% as compared to the
      control. The incorporation of amino acids into heart ribosomes at the late stage
      of hyperfunction (after 6 months) was decreased by 46% as compared to the early
      stages. The addition of homologous tRNA to the cell-free system of protein
      synthesis under prolonged heart hyperfunction stimulated the incorporation of
      amino acids into the ribosomes by 40--50%.

PMID- 1022277
TI  - [Formation of the prothrombin-phosphatidyl serine and thrombin-phosphatidyl
      serine complex].
AB  - A possibility of formation of the thrombin-phosphatidyl serine and prothrombin
      phosphatidyl serine complex is discussed. Prothrombin incubation with 131J
      labelled phosphatidyl serine and its subsequent activation results in a formation
      of a thrombin-phosphatidyl serine--131J-complex. The radioactive label is also
      detected in the protein precipitate after thermodenaturation of thrombin
      preincubated with 131J-labelled phosphatidyl serine, which suggests that thrombin
      is firmly bound to phosphatidyl serine. The formation of the thrombin
      phosphatidyl serine and prothrombin-phosphatidyl serine complex is supported by
      data of gel-filtration on Sephadex G-200 and acrylexes P-150 and P-60, as well as
      by differential spectrophotometry.

PMID- 1022278
TI  - [Interaction of dexamethasone-receptor complexes with rat liver nuclei and DNAs].
AB  - The role of DNAs in the nuclear binding of dexamethasone-receptor complexes (DRC)
      was studied. The cytosolic receptors from rat liver have a sedimentation
      coefficient of about 7S, the Stock's radius--of about 50 A and possess a high
      affinity to dexamethasone (Kas = 2,6 X 10(8) M-1). Their capacity is 3 X 10(-13)
      and 5.5--7.0 X 10(-12) mole of dexamethasone per mg cytosolic protein and mg DNA,
      respectively. DRC has the ability to bind to the nuclei of rat liver. DRC binding
      to nuclei is increased approximately 3-fold by temperature activation of cytosol.
      The nuclear acceptor sites are saturated at the level of 16.2 pmoles of bound DRC
      per mg nuclear DNA. Free DNA has the ability to compete with nuclei for binding
      with DRC. Temperature-activated DRC can bind both with homo- and heterologous
      DNAs. Secondary DRC-DNA complexes were isolated by means of gel filtration on
      Sepharose 4B. Thermal denaturation of DNA decreases its ability to bind DRC
      approximately 2-fold. DNAs of a similar nucleotide composition, i.e. DNA from rat
      liver (GC = 43 mole%) and DNA from Photobacterium belozerskii (GC = 44 mole%),
      have a close DRC-binding ability. At the same time, these DNAs bind about 1.5
      fold less DRC, as compared to DNA from Pseudomonas aeruginosa (GC = 67 mole%) and
      about 1.5-fold more, than does DNA from T2 phage (GC = 35 mole%). Thus the
      positive correlation between the GC composition of DNA and its DRC-binding
      ability was established. Unique sequences (Cot greater than 600) bind several
      times less DRC than the reiterated sequences (also denaturated) (Cot = O--600) of
      rate liver DNA. Thus, DNA can be considered as a nuclear acceptor of DRC. It is
      assumed, that DRC is able to recognise in DNA certain short GC-rich sequences,
      distributed in the rate genome in a non-random fashion.

PMID- 1022279
TI  - [Changes in mitochondria density during oogenesis of loach].
AB  - The growth of loach oocytes is accompanied by an increase in the density of
      mitochondria. Simultaneously with the increase in density an acceleration of 14C
      valine incorporation into mitochondrial proteins takes place. It is assumed that
      the increase in mitochondria density during oogenesis is due to an increase in
      the amount of membrane material per unit of mitochondria weight.

PMID- 1022280
TI  - [Chemical composition of surface antigens in the pseudotubercular microbe].
AB  - Superficially-active complexes, having a toxic effect and promoting
      generalization of the infestation process in the animal organism have been
      isolated from the pseudotubercular microbe. The chemical composition of these
      biopolymers has been studied.

PMID- 1022281
TI  - [Effects of polyene antibiotics on the membranes of dog kidney isolated nuclei].
AB  - The effects of amphotericin B and nistatin on the membranes of dog kidney
      isolated nuclei after their incubation with the antibiotics in question, have
      been studied. It is found that the polyene antibiotics, though they are
      superficially-active compounds, have no solubilizing effect on nuclear membranes
      and do not change their chemical composition. Electrophoretic study has revealed
      that nuclear membrane proteins, besides high- and low-molecular protein
      components, also contain a large amount of histones. The incubation of the nuclei
      with the polyene antibiotics results in marked changes in the fractional
      composition of nuclear membrane proteins, the most significant changes being
      induced by amphotericin B. It is assumed that polyene antibiotics induce
      proteolytic degradation of nuclear membrane proteins.

PMID- 1022282
TI  - [Sedoheptulose-1,7-diphosphate as a source of pentose phosphates in heart
      muscle].
AB  - A possibility and some peculiarities of phosphatase degradation of sedoheptulose
      1,7-diphosphate in the myocardium has been demonstrated. The reaction products
      are inorganic phosphate and sedoheptulose-7-phosphate; the latter product is the
      substrate of the transketolase reaction during pentose phosphates production. The
      process is largely localized in the soluble fraction of heart cells; in cellular
      organelles it is represented in a lesser degree. Possible regulatory mechanisms
      of pentose phosphate biosynthesis in animal tissues are discussed.

PMID- 1022283
TI  - [Specific modification of free lysine amino groups of histidine decarboxylase
      from Micrococcus sp. n. by trinitrobenzene sulfonic acid].
AB  - It has been found that 14 lysine residues are accessible for trinitrobenzene
      sulfonic acid (TNBS) in the molecule of histidine decarboxylase (HDC). The other
      62 lysine residues in the molecule of native HDC are masked and inaccessible for
      TNBS. It is demonstrated that the SH- and alpha-amino groups of methionine are
      not modified by TNBS. A correlation between the decarboxylase activity of the
      enzyme and the degree of its trinitrophenylation has been studied. HDC, whose
      molecule contains 3--9 TNP groups, retains up to 90--97% of its initial activity.
      Trinitrophenylation of 14 lysine residues induces inactivation of HDC by 33--34%,
      which probably depends on conformational changes or steric hindrances, occurring
      in the catalytic site of the modified active centre of HDC. Using circular
      dichroism and fluorescence methods as well as disc-electrophoresis in
      polyacrylamide gel, it has been shown that trinitrophenylation does not cause any
      significant changes in the enzyme structure. The TNP groups have been found to be
      localized in the large and small subunits of the HDC molecule.

PMID- 1022284
TI  - [Inhibitory effect of alpha-methyl-1-adamantane methylamine hydrochloride
      (rimantadine) on RNA-dependent RNA polymerase induction in culture of cells,
      infected with influenza virus].
AB  - An anti-influenza preparation, rimantadine (alpha-methyl-1-adamantane methylamine
      hydrochloride) at concentrations of 10--25 mkg/ml depresses the RNA-dependent RNA
      polymerase induction in a culture of cells infected with influenza virus (fowl
      plague virus). The inhibitory effect is also observed 2 hours following cell
      infection. In vitro studies have demonstrated that rimantadine has no effect on
      the activity of virus-induced RNA-dependent RNA polymerase, as well as on that of
      RNA-dependent RNA polymerase associated with virus particles.

PMID- 1022285
TI  - [14C-1-Tyrosine metabolism on rat thyroid gland].
AB  - Amino acid composition of incubation medium, thyroid tissue hydrolysate and
      purified thyreoglobulin (Tr) preparations, isolated after 5 hour incubation with
      14C-1-tyrosine in Jey medium is studied by means of electrophoresis and
      autoradiography. 5 radioactivity stains are detected on radioelectrophoregram of
      incubation medium, 2 of them corresponding to tyrosine and serine. 2 stains
      corresponding to diiodotyrosine and triiodotyronine are found in hydrolysate of
      thyroid tissue. No radioactive stains were found on radioelectrophoregrams of
      thyreoglobulin. The data obtained indicate that in the reaction of condensation
      of iodotyrosines into iodotyronine a lateral chain of iodotyrosine (serine)
      splits off. Thyroid hormones biosyntesis takes place by condensation of either a
      single free molecule of iodotyrosine with iodotyrosyl residue of polypeptide
      chain of pre-synthesized thyreoglobulin, or two free molecules of iodotyrosine.

PMID- 1022286
TI  - [Identification of hexokinase synthesizing polyribosomes in human normal and
      tumor tissues].
AB  - Comparative study of concentrations of growing hexokinase subunits polypeptide
      chains in the polyribosomes from normal and tumour human stomach tissue is
      studied using specific antiserum to hexokinase isoenzyme from human stomach
      tumour tissue. It is shown by two different methods (chromatography on Sepharose
      46 and sucrose concentration gradient analysis) that the content of hexokinase
      polypeptides in stomach tumour is several times higher than in homologous normal
      tissue. The acta obtained show that the high activity of hexokinase in tumour
      tissues is due to the increased synthesis rate of the enzyme.

PMID- 1022287
TI  - [Investigation of ribosomal RNAs from liver mitochondria of albino rats].
AB  - Study of sedimentation coefficients of rat liver mt-rRNAs labelled in vivo under
      conditions of selective inhibition by actinomycin D of nuclear RNAs biosynthesis,
      in hypoosmic system of isolated mitochondria, and of mt-rRNAs isolated from
      purified 55 ribosomes revealed that mt-rRNAs are represented by 16S and 12S
      components. Both components are found to be of AU-type. Anomalous behaviour of
      mtRNA on MAK columns is observed. Some aspects of isolation and identification of
      mt-rRNAs in higher organisms are discussed.

PMID- 1022288
TI  - [Sterospecific selection of nucleophilic compounds in the chymotrypsin-catalyzed
      formation of the peptide bonds].
AB  - The course of stereospecific selection of nucleophilic compounds was studied in
      the reaction of acyl-enzymes interaction with razemic substrate-like
      nucleophiles, e.g. amino acid esters, by measuring optical rotation or
      incorporation of labelled D-compounds. It was shown that the acyl-enzymes are not
      responsible for the stereospecific selection of substrate-like nucleophiles.
      Since stereospecific selection of nucleophiles occurs in some chymotrypsin
      catalyzed reactions, such selection may be produced by chymotrypsin till the
      formation of an acyl-enzyme compound with the substrate at the enzyme-inhibitor
      stage (or the Michaelis complex) with nucleophilic compounds. Even under the
      optimal conditions no absolute stereospecific selection of nucleophiles occurred,
      as was observed in case of a substrate (a donor of the acyl amino acid residue),
      undergoing degradation. An essential role of a specific site of nucleophile
      binding in the reactions of chymotrypsin-catalyzed peptide bond formation, is
      emphasized.

PMID- 1022289
TI  - [Extracellular nuclease of Bacillus mesentericus].
AB  - Bacillus mesentericus is found to secrete three type of nucleases: alkaline
      ribonuclease (EC 2.7.7.17), acidic ribonuclease (EC 2.7.7.17) and Ca2+-activated
      exonucleease (EC 3.1.4.7). These nucleases are purified and characterized. They
      are similar to those from Bac. subtilis in main biochemical and physico-chemical
      properties and in their chromatographical behaviour. Studying physiological
      functions of Bac. mesentericus extracellular nucleases, it is shown that
      bacteria, which are capable to produce extracellular nucleases, utilize exogenous
      RNAs and a bit worse, DNAs as a single and additional source of nitrogen or
      phosphorus. In view of this it is believed that extracellular nucleases
      participate in bacteria nutrition.

PMID- 1022290
TI  - [Prothrombin activation by immobilized thrombin].
AB  - The ability of thrombin, immobilized on BrCN-activated Sepharose 4B, to split
      prothrombin, was studied. Immobilized thrombin retained up to 70% of its esterase
      activity and about 5% of its coagulating activity; it was also found to induce
      partial proteolysis of prothrombin. Two products of prothrombin degradation
      isolated, i.e. P1 (m. w. 50.000-52.000) and P2 (m. w. 22.000-24.000), did not
      show either the thrombin or the prothrombin activities. P1 was converted into
      thrombin under the action of tripsin or Factor Xa. The rate of conversion was
      considerably increased after addition of Factor V, thromboplastin and Ca2+ ions.
      Intravenous administration of P1 to rats resulted in changes in the coagulating
      system of blood, which may be probably indicative of the stimulation of the
      anticoagulating system. P2 possessed no thrombogenic activity.

PMID- 1022291
TI  - [Acceptor activity of 4-N-acetylcytidine in the synthesis of (3'-5')
      internucleotide bond catalyzed by pancreatic nuclease].
AB  - Cytidine and 4-N-acetylcytidine were compared as phosphate acceptors in
      dinucleoside monophosphate synthesis catalyzed by pancreatic ribonuclease with
      uridine-2',3'-cyclophosphate and cytidine-2',3'-cyclo phosphate as phosphate
      donors. Because of low solubility of 4-N-acetylcytidine in water, the synthesis
      was carried out in aqueus-organic media. The results obtained indicate that
      acetylation of the exoaminogroup of cytidine decreases its acceptor activity. For
      the first time uridilyl-(3'-5')-4-N-acetylcytidine and cytidilyl-(3'-5')-4-N
      acetylcytidine are prepared enzymatically by pancreatic ribonuclease.

PMID- 1022292
TI  - [Properties and substrate specificity of proteinase from buckwheat seeds].
AB  - A thiol proteinase was isolated from buckwheat seeds and purified 300-fold, using
      ammonium sulfate, acetone fractionation ion-exchange chromatography on Sephadex
      CM-50 and electrofocussing. The proteinase preparation obtained was found
      homogenous after polyacrylamide gel electrophoresis at pH 4.5. The molecular
      weight of the enzyme (75.000) was determined by gel-filtration through Sephadex G
      100. The activation of proteinase by cysteine, 2-mercaptoethanol and
      dithiothreitol, its inhibition by p-chloromercurybenzoate and the absence of
      inhibition by diisopropyl fluorophosphate and EDTA suggest that the enzyme
      isolated is a thiol proteinase. The enzyme hydrolyzed many peptide bonds in the B
      chain of insulin, showing high substrate specificity. The glutelin and globulin
      fractions of buckwheat seed proteins were hydrolyzed by the enzyme. It is assumed
      that the hydrolysis of reserve proteins of buckwheat seeds is the main function
      of the proteinase isolated.

PMID- 1022293
TI  - [Use of bifunctional reagents in the study of histones topography in chromatin].
AB  - The ability of bifunctional reagents--diimidoesters of sebacinic acid and
      tetranitromethane--to cross-link the histones in rat thymus chromatin was
      studied. The histone polymers formed were extracted with 0,8 N H2SO4 and analyzed
      by polyacrylamide gel electrophoresis. The results obtained suggest that in
      chromatin some histone fractions are localized in immediate proximity to each
      other. This phenomenon may probably account for the formation of chromatin
      structure and its functioning in the cell.

PMID- 1022294
TI  - [Comparative study of solubilized and membrane-bound acetylcholinesterase of
      sarcolemma].
AB  - Comparative kinetic studies of membrane-bound and solubilized sarcolemmal
      acetylcholinesterase reveal some difference in concentration-activity curves. A
      deviation from normal Michaelis-Menten kinetics is found in case of membrane
      bound acetylcholinesterase. The solubilization of sarcolemma by a solution of
      high ionic strength or by sonication normalizes the reaction kinetics. It is
      shown that the amount of SH-groups in intact sarcolemma available for DTNB in the
      presence of sodium dodecyl sulphate, is about twice of that in the absence of
      sodium dodecyl sulphate. In case of the solubilized fraction of sarcolemma (by a
      solution of high ionic strength or by sonication), the amount of SH-groups
      available for DTNB in the presence and in the absence of sodium dodecyl sulphate
      is similar.

PMID- 1022295
TI  - [Surface membrane proteins of endoplasmic reticulum in brain and liver cells].
AB  - A comparative study of proteins adsorbed on outer surface of microsomal membranes
      was carried out. Electrophoretic differences between endoplasmic reticulum
      proteins from liver and brain cells were revealed. These differences were not
      observed in the presence of sodium dodecyl sulphate. Proteins of brain microsomes
      are shown to bind in vitro with membranes of brain endoplasmic reticulum to a
      higher extent than with liver microsomal membranes.

PMID- 1022296
TI  - [Study of membrane-bound ribosomes during pea chloroplasts formation].
AB  - Membrane-bound ribosomes of chloroplasts, isolated from pea seedlings during
      grana formation, can be partially liberated by 0.5 M KCl and 0.001 M puromycin.
      In case of mature chloroplasts, after the completion of grana formation process
      these agents are inefficient, and liberation of ribosomes and polyribosomes may
      be achieved only after solubilization of thylakoid membranes by 1% Triton X-100.
      Electron microscopic study of the heavy membrane fraction of young chloroplasts
      reveals electron-transparent membranes, containing rings and discs of thylakoids
      with a diameter of about 2 mum. These rings are liberated together with ribosomes
      under the action of 0.5 M KCl; Triton X-100 liberates equally-sized annular
      polyribosomes. The rings detected in chloroplast membranes at early stages of
      development are regarded as structures, precursor grana thylakoids, and the
      annular polyribosomes included into them as immediate participants of thylakoid
      morphogenesis.

PMID- 1022297
TI  - [Age variability and mean frequency of Barr-positive nuclei in different
      contingents of the population of Kuzbass].

PMID- 1022298
TI  - [Effect of mutations leading to disorders in histidine synthesis on lipids and
      fatty acids of Candida tropicalis strain D-2].

PMID- 1022299
TI  - [Colorimetric modification of a method of determining alpha-amino acid nitrogen
      by means of producing complex copper compounds].

PMID- 1022300
TI  - [Comparison of genome organization in closely related forms of organisms, as an
      example fish of the genus Coregonus].

PMID- 1022301
TI  - [Comparative study of the effect of theophylline and alcohols on ion transport in
      frog skin].

PMID- 1022302
TI  - [Structural organization of the "associative" region of the hedgehog neocortex].

PMID- 1022303
TI  - [Fromation of somatic cortical projections during cat ontogenesis].

PMID- 1022305
TI  - [Agents of zoonoses and their habitat. I. Ecologic aspects of parasitism].

PMID- 1022304
TI  - [Activator of potassium permeability and peroxidase inhibitor in the serum of
      horses subjected to physical stress].

PMID- 1022306
TI  - [Absence of response of DDT by Ixodes persulcatus P. Sch. (Parasitiformes,
      Ixodidae)].

PMID- 1022307
TI  - [Regulatory properties of "lyophilized aqueous environment" obtained from a
      "concentration" population of Rana arvalis tadpoles].

PMID- 1022308
TI  - [Comparative characteristics of the baseline spike activity of afferent and
      efferent neurons in chronic and acute experiments].

PMID- 1022309
TI  - [Relationship between maintenance in different ecologic environments and changes
      in the hematologic indices of crossbred sheep].

PMID- 1022310
TI  - [H3-leucine incorporation in neurons of different murine brain structures upon
      elaboration of a defensive conditioned reflex].

PMID- 1022311
TI  - [Spatial distribution of primary responses in the visual projection zone of the
      guinea pig cortex].

PMID- 1022312
TI  - [Changes in the bioelectrical activity of the hippocampus and sensomotor cortex
      of the brain following administration of sex steroid hormones against a
      background of cholino-, adreno- and serotonin-reactive system stimulation].

PMID- 1022313
TI  - Advances in glomerular physiology.

PMID- 1022314
TI  - What is a clinical pharmacologist today.

PMID- 1022315
TI  - [Karyometry of thymic reticular cells in the rat. Effect of hydrocortisone  and
      adrenalectomy].
AB  - A new process in taxinomic analysis clearly confirmed the presence of three
      different types of cells (epithelial, hypertrophic and mesenchymal) in the
      reticular zone of the thymus. The injection of hydrocortisol as well as
      adrenalectomy induced specific changes in nuclear surfaces of three cell types,
      while hydrocortisol tented to increase the surface of epithelial and mesenchymal
      cells, adrenalectomy reduced it, while a modification was seen in the percentages
      relative of the cell types. In adrenalectomized animals, the effect result was
      counteracted by injections of hydrocortisol.

PMID- 1022316
TI  - Study of a microassay for the quantitation of cytotoxic antitumor antibody, using
      125I-iododeoxyuridine as a target cell label; detection of a static effect on
      cell DNA synthesis.
AB  - The different steps of a microassay for the quantitation of cytotoxic antitumor
      antibody, are studied in detail. It is shown that the use of 125I
      Iododeoxyuridine as the target cell label, at the end of the assay, after action
      of serum and complement, allows the advantages available with this isotopic label
      to be retained and to avoid the main disadvantage due to its non specific
      toxicity for the target cells. Furthermore, this technique is shown to be able to
      detect non only a killer effect of immune sera on specific target cells with
      complement but also an additionnal static effect of DNA synthesis : this effect
      is complement dependent and transitory.

PMID- 1022317
TI  - [Abdominal manifestations of hereditary angioneurotic edema. Importance of the
      exploration of the complement system (apropos of 29 families)].
AB  - Abdominal manifestations are almost constantly present (85% of cases) in the
      current form of hereditary Quincke's disease. In some cases, these abdominal
      manifestations occur even when cutaneomucosal edema is not present which leads to
      unwarranted often repeated and sometimes dangerous surgery. Apart from a story of
      heredity diagnosis of such troubles is possible, provided the total complement
      has been assayed to note its sharp fall. It can be subsequently explained by a
      functional defect of the C1 esterase inhibitor or alpha2-neuraminoglycoprotein.

PMID- 1022318
TI  - [The auto genesis of the cell and the theory of evolution (author's transl)].

PMID- 1022319
TI  - [Comparison of the formation of the mesonephric, medullary, and adrenal blastema
      of common toad embryos, Bufo bufo L., and the clawed toad, Xenopus laevis Duad.
      (anuran amphibians)].

PMID- 1022320
TI  - [The differentiation of the somites in embryos of two anuran amphibians: the
      common toad (Bufo bufo L.) and the frog (Rana dalmatina Bon)].

PMID- 1022321
TI  - [Interferon 1976. II. The significance of interferon in medicine (author's
      transl)].

PMID- 1022322
TI  - [The preparatory motor potential of the brain and cooperation of the hemispheres
      in unimanual contractions of the left hand (author's transl)].

PMID- 1022323
TI  - [Pulvinarotomy as a new method in treating derangements of motor activity
      (author's transl)].

PMID- 1022324
TI  - [Medical and surgical treatment of strumitis (author's transl)].

PMID- 1022325
TI  - [Injuries of the colon and rectum (author's transl)].

PMID- 1022326
TI  - [Peroperative follow-up of hemodynamics on surgical correction of acquired heart
      defects (author's transl)].

PMID- 1022327
TI  - [Changes in protein metabolism following gastric surgery studied by means of
      albumin-125I (author's transl)].

PMID- 1022328
TI  - [Transitory cerebrospinal fluid pleocytosis in a period of increased incidence of
      epileptic seizures (author's transl)].

PMID- 1022329
TI  - Dominant-and-recessive epistasis in a homeotic mosquito mutant.
AB  - Following selection for 15 generations a pure strain of a homeotic mutant spur
      was isolated from a Brazilian population of the mosquito Culex pipiens fatigans.
      Monohybrid crosses showed a 13:3 segregation indicating dominant-and-recessive
      epistasis for wild-type vs. spur. This implies that a dominant allele at one
      locus and a recessive at the other interact to produce the mutant phenotype.
      Dihybrid crosses with linkage group II markers yellow and ruby gave 39:13:9:3
      ratios indicating independent segregation. However, the dihybrid cross with
      linkage group I marker maroon showed a highly significant departure from
      39:13:9:3 ratio. Data available indicate that the phenotype spur is controlled by
      a dominant epistat in linkage group III and a recessive epistat (approximately
      31.9 crossover units from maroon) in linkage group I.

PMID- 1022330
TI  - Genetic analysis of nurse dams selected for six-week body weight or postweaning
      gain in mice.
AB  - A modified crossfostering technique was developed to compare the performance of
      nurse dams in selected and control populations of mice. The H6 and M16
      populations were selected for increased 6-week body weight and 3- to 6-week
      postweaning gain, respectively, while the C2 and ICR populations were the
      respective controls. Crossfostering was performed using H6, M16 and their
      reciprocal F1 crosses as nurse dams in the selected crossfostering group and C2
      ICR and their reciprocals in the control group. Measurements recorded for nurse
      dams included mean body weight of 8 young within a nursed litter at birth (MWB)
      and 12 days of age (MW12). The latter was used as a measure of postnatal maternal
      performance. Other traits recorded for nurse dams were number born (NB), body
      weight at parturition (DWP) and 12 days postpartum (DW12), and weight gain (DWG),
      feed intake (FED) and efficiency (EFF = DWG/FED) for the first 12 days of
      lactation. The correlated response in MW12 was negative (P less than .01) for M16
      and essentially zero for H6. Both lines exhibited positive (P less than .01)
      correlated responses in DWP and DW12 and no change in EFF. Only the H6 line
      increases significantly in DWG and FED as a result of selection. NB increased in
      M16 and H6, but was significant for the latter population only. Population
      differences in selection response [(M16-ICR)-(H6-C2)] were significant for FED
      only, primarily due to average direct genetic effects. Direct comparisons of M16
      and H6 indicated that M16 was larger in DWP and DW12 but smaller in DWG and EFF.
      Average direct genetic effects favored M16 for NB, DWP, and DW12, whereas average
      maternal genetic effects favored H6 for NB, DWP, DW12 and FED. Percent direct
      heterosis, in F1 crosses of selected populations was significant for MW12 (13.7%)
      ,FED (10.8%) and NB (11.4%). Direct heterosis in F1 crosses of the controls was
      significant for MW12 (9.4%), NB (6.6%), DWP (3.5%), DW12 (3.3%) and FED (4.4%).
      The effects of MW12, DWG and metabolic body size (MBS) accounted for 47% of the
      variation in FED, pooled within populations. Of these variables, MW12 accounted
      for the highest proportion (32%) of variation in total feed intake.

PMID- 1022331
TI  - Cytological effects of an organic phosphate pesticide on human cells in vitro.
AB  - This investigation was undertaken to determine the radiomimetic effects in vitro
      of the insecticide guthion [azinophos-methyl; O, O-dimethyl S-(4-oxobenzotriazino
      3-methyl) phosphorodithioate] on two human cell lines, diploid (WI-38) and
      heteroploid (HEp-2). In WI-38 cells, dosages of 120, 140 and 160 microng/ml of
      guthion were effective in inducing an average chromosome breakage of 0.042, 0.058
      and 0.165 respectively per cell. In control cells, the mean number of breaks per
      cell was 0.011. Chromosome breakages were significantly higher in treated cells.
      Since guthion prevents cells from entering into mitosis during treatment, the
      number of mitiotic cells decreases rapidly following treatment with higher
      concentrations. Similar dosages in treated HEp-2 cells also induced a high
      incidence of chromosome aberrations, the most common being chromatid breaks and
      exchanges. Infrequently noted were mild failure of condensation, despiralization,
      secondary constrictions, gaps, dicentric chromosomes and pulverization. To date,
      this study reaffirms previous findings of the potentially hazardous, mutagenic
      effects of guthion.

PMID- 1022332
TI  - Effects of ozone on meiotic chromosomes of Vicia faba.
AB  - All of the levels of ozone used in these experiments caused morphological damage
      to plants of Vicia faba L., but only the dose of 200 parts per hundred million
      for 4 h or 8 h caused chromosomal damage in the microsporocytes. Significant
      chromosomal damage appeared 24 h after fumigation in metaphase I and anaphase I -
      telophase I but no significant damage was found in anaphase II - telophase II.
      This observation suggests that chromosomes are more susceptible to ozone during
      early stages of meiosis than at later stages. Chromosomal damage was of two
      types: physiological, as suggested by chromosome stickiness and physical, as
      indicated by bridges, fragments, and micronuclei.

PMID- 1022333
TI  - Meiotic evidence for pericentric inversion polymorphism in Junco (Aves).
AB  - Species of the genus Junco are polymorphic for chromosomes 2 and 5. Diplotene
      karyotypes of 61 adult male Dark-eyed Juncos, Junco hyemalis, were analyzed in
      order to determine the basis of the polymorphisms. Individuals carrying
      heterozygous bivalents of the polymorphic chromosomes have fewer chiasma than
      homozygous individuals. These data suggest that two separate pericentric
      inversions are at the basis of the polymorphisms.

PMID- 1022334
TI  - [Determination of caffeine and quinine in the medicinal preparation Chinascorbin
      dragees by means of differential titration in non-aqueous medium].

PMID- 1022335
TI  - [Recent advances in the chemistry and biosynthesis of ergot alkaloids].

PMID- 1022336
TI  - [Formulation of drugs and liberation of active ingredients].

PMID- 1022337
TI  - [Problem of moulds and yeasts in drugs].

PMID- 1022338
TI  - VII. A procedure for the preparation of diribonucleoside monophosphates having
      natural linkage.

PMID- 1022339
TI  - Studies on benzoheterocyclic derivatives. XVII. Analgesic activity of
      dihydrobenzofuran derivatives.

PMID- 1022340
TI  - Effect of 1,2-benzisoxazole-3-acetamidoxime on caudato-thalamo-cortical system in
      cats.

PMID- 1022341
TI  - Identification of a novel aminonucleoside produced by Enterobacter sp. as 2'
      amino-2'-deoxyguanosine.

PMID- 1022342
TI  - Effect of age on the distribution of drug in blood.

PMID- 1022343
TI  - Effect of ginseng saponins on cholesterol metabolism. II. Effect of ginsenosides
      on cholesterol synthesis by liver slice.

PMID- 1022344
TI  - Separation and determination of cardiac steroids by high-pressure liquid
      chromatography.

PMID- 1022345
TI  - Analysis of d-ethambutol by circular dichroism of its copper chelates.

PMID- 1022346
TI  - Disk to sphere transformation of erythrocyte induced by 1-anilino-8-naphthalene
      sulfonate (ANS). II. Quantitative study on adsorption of ANS by whole erythrocyte
      and by ghost membrane.

PMID- 1022347
TI  - Conversion of acylamidopenicillins to phosphoramidopenicillins, and removal of
      their phosphoryl side chain.

PMID- 1022348
TI  - Effect of pre-administered fats and fatty acids on the intestinal absorption of
      tryptophan in the rat.

PMID- 1022349
TI  - Amino acids and peptides. II Synthesis of stereoisomeric alanine containing
      peptide derivatives and their effects on germination of Bacillus thiaminolyticus
      spores.

PMID- 1022350
TI  - Chymopapain II. Photooxidation of histidine residues.

PMID- 1022351
TI  - Mechanism for interference of carbamazepine in Porter-Silber reaction for
      determination of urinary 17-hydroxycorticosteroids.

PMID- 1022352
TI  - A new product of cholesterol by metal-free autoxidation in aqueous dispersion.

PMID- 1022353
TI  - Structure of a new antimicrobial unsaturated fatty acid from Sm. kitasatoenis NU
      23-1.

PMID- 1022354
TI  - Effect of substituents on the hydrolysis of substituted phenyl beta
      acetylglucosaminides by bovine liver beta-acetylglucosaminidase.

PMID- 1022355
TI  - Effects of perfusate constituents on transmucosal fluid movement and drug
      absorption in rat small intestine.

PMID- 1022356
TI  - Decrease of calcium concentration in urine of rats treated with stannous
      chloride.

PMID- 1022357
TI  - Effect of ginseng saponin on liver glycogen content.

PMID- 1022358
TI  - The effect of dosage form on absorption of vitamin A into lymph.

PMID- 1022359
TI  - Studies on the synthesis of cardiotonic steroids. II. Synthesis of 17 beta-(-3
      furyl)-5beta, 14beta-androstane-3beta, 14beta-diol.

PMID- 1022360
TI  - Formation of 4-formylaminoantipyrine as a new metabolite of aminopyrine. II.
      Enzymatic demethylation and oxidation of aminopyrine and 4
      monomethylaminoantipyrine.

PMID- 1022361
TI  - Adolescent therapists.

PMID- 1022362
TI  - A regional mental health centre for children and adolescents: the Department of
      Psychiatry for Children and Adolescents at the Hotel-Dieu du Sacre-Coeur de
      Jesus, Quebec City.

PMID- 1022363
TI  - "Noc noc"--what's there? Three basic considerations in evaluating community
      mental health center programs.

PMID- 1022364
TI  - Combined approaches in the treatment of conflicted children and their families.

PMID- 1022365
TI  - An objective patient classification system in psychiatric nursing.

PMID- 1022366
TI  - National Health Research and Development Program.

PMID- 1022367
TI  - Teaching family therapy by simulation.

PMID- 1022368
TI  - Early stimulation: a rationale.

PMID- 1022369
TI  - Cancer of the GI tract. Foreword.

PMID- 1022370
TI  - Diet and gastrointestinal cancer.

PMID- 1022371
TI  - Genetic aspects of gastrointestinal cancer.

PMID- 1022372
TI  - Genesis of colorectal cancer.

PMID- 1022373
TI  - Experimental carcinogenesis in the digestive organs.

PMID- 1022374
TI  - Cell proliferation in normal, preneoplastic and neoplastic gastrointestinal
      cells.

PMID- 1022375
TI  - Potential of endoscopy, biopsy and cytology in the diagnosis and management of
      patients with cancer.

PMID- 1022376
TI  - Newer radiological techniques in the diagnosis  of gastrointestinal cancer.

PMID- 1022377
TI  - The present status of carcinoembryonic antigen (CEA) in diagnosis, detection of
      recurrence, prognosis and evaluation of therapy of colonic and pancreatic cancer.

PMID- 1022378
TI  - Tumour markers, enzymes and hormonal markers.

PMID- 1022379
TI  - Paraneoplastic syndromes associated with gastrointestinal cancer.

PMID- 1022380
TI  - Surgical management of gastrointestinal cancer.

PMID- 1022381
TI  - Radiation therapy: results and future possibilities.

PMID- 1022382
TI  - Chemotherapy, adjuvant to surgery, for gastrointestinal cancer.

PMID- 1022383
TI  - Management of precancerous lesions of the gastrointestinal tract.

PMID- 1022384
TI  - Clinical systems engineering.

PMID- 1022385
TI  - Nyack shared engineering plan.

PMID- 1022386
TI  - Clinical engineering: the means by which instrumentation and technology can be
      used for health service delivery.

PMID- 1022387
TI  - In-hospital medical equipment maintenance.

PMID- 1022388
TI  - Biomedical technologists--who's qualified?

PMID- 1022389
TI  - Clinical engineering at Sinai Hospital of Baltimore.

PMID- 1022390
TI  - The coming generation to match the new technology.

PMID- 1022391
TI  - Bioengineering at University of Cape Town & Groote Schuur Hospital.

PMID- 1022392
TI  - High frequency electrocardiography.

PMID- 1022393
TI  - Cost analysis of a viable clinical engineering service.

PMID- 1022394
TI  - Hospital safety and medical instrumentation practices.

PMID- 1022395
TI  - What is instrumentation science?

PMID- 1022396
TI  - Biomedical engineering technician assistance.

PMID- 1022397
TI  - An overview of health care equipment.

PMID- 1022399
TI  - Preventive maintenance: spirometers.

PMID- 1022398
TI  - Hospital technical services and electrical safety.

PMID- 1022400
TI  - Safe use of electricity in the hospital.

PMID- 1022401
TI  - Hospital mortality in patients with acute myocardial infarction: five-year
      experience.
AB  - Mortality during the hospitalization period was analyzed in a sample of 786
      patients with acute myocardial infarction [AMI], admitted to the coronary care
      unit within a five-year period from a catchment area of 200 000 urban
      inhabitants. The total mortality during the hospitalization period amounted to
      19.2%. The prognostic significance of certain clinically meaningful phenomena was
      appraised on the basis of their association to the mortality. It was demonstrated
      that the factors decisive for the prognosis of a patient with AMI are age,
      previous myocardial infarction, extent and localization of the ischaemic lesion
      apparent from the ECG tracing, and, in addition, presence of the atrioventricular
      and intraventricular conduction defects, especially if combined with anterior
      myocardial infarction. Patients with a high cumulation of these prognostic
      factors exhibited severe signs of mechanical heart failure, which is the
      mechanism of death in practically all of the deceased patients under the present
      possibilities of treatment.

PMID- 1022402
TI  - Coagulability of arterial and venous blood in healthy subjects, patients with
      coronary atherosclerosis, and patients with rheumatic cardiopathies.
AB  - Coagulability of arterial and venous blood was studied in 50 healthy subjects and
      in 179 patients with circulation disturbances caused by coronary atherosclerosis
      and rheumatic cardiopathies. All indicators characterizing the individual
      haemocoagulation phases were respected. In the healthy subjects the coagulative
      and fibrinolytic activities of venous blood were higher than those of arterial
      blood. In the patients with heart failure the coagulability of venous blood
      decreased and that of arterial blood increased. These phenomena were accompanied
      by fibrinogenaemia, appearance of fibrinogen B in the blood, elevation of free
      heparin, and inhibition, but occasional activation, of fibrinolysis in both
      vascular systems. The findings seem to signalize enhanced intravascular blood
      coagulability in patients with circulation disturbances, which phenomenon has to
      be taken into account in the treatment of such patients.

PMID- 1022403
TI  - Long-term spontaneous variability of left ventricular end-diastolic pressure.
AB  - In two different catheterization studies the authors repeatedly measured the left
      ventricular pressures in 43 men with chronic stabilized ischaemic heart disease.
      The interval between both tests averaged two months. The end-diastolic and
      systolic pressure and the heart rate were measured. A comprehensive evaluation of
      the results revealed no statistically significant differences between the results
      of the first and second measurements. Their correlations are expressed by the
      following correlation coefficients: r = 0.80 for the end-diastolic pressure, r =
      0.76 for the systolic pressure, and r = 0.74 for the heart rate. The study offers
      first information about the long-term variability of the left ventricular end
      diastolic pressure and contributes to a more exact appraisal of its value in
      evaluation of natural course or long-term therapeutic intervention of heart
      diseases.

PMID- 1022404
TI  - Monophasic action potentials of the right atrium during atrial fibrillation in
      man.
AB  - In 28 patients with established atrial fibrillation [AF], right atrial monophasic
      action potentials [MAP] were recorded before DC shock. A close correlation was
      found between the atrial rate and MAP duration of the fibrillatory waves [FW].
      The duration of MAPs ranged between 1 and 6 mV. The atrial rate ranged between
      311 and 578 per minute, the highest rates were found during lone AF. In two
      patients in whom cardioversion failed, a prolongation of right atrial MAP
      duration of the FW was noted. The efficacy of DC shock and the maintenance of
      sinus rhythm after cardioversion was greater in patients with AF having a slower
      rate and a longer MAP.

PMID- 1022405
TI  - Contribution to the vector analysis of the orthogonal electrocardiogram.
AB  - A method is described for characterizing the spatial directions of vectors with
      the aid of the angle alpha, characterizing the direction of the vector's
      projection upon the frontal plane, and angle beta, indicating the deflection of
      the spatial vector from the frontal plane. Angle alpha is expressed in the mode
      used with the conventional ECG system [from 0 degrees to +/- 180 degrees], and
      angle beta from 0 degrees to +/- 90 degrees. Calculations are made with the aid
      of algebraic formulae, and the results are tabulated. To facilitate the
      calculations of the magnitudes and directions of vectors in the space with
      respect to the orthogonal leads, and for better illustration, special schemes are
      presented.

PMID- 1022406
TI  - Design and methodology of the Zagreb preliminary study: response rates at the
      study stages.
AB  - A procedure for recruitment of a trial cohort from a demographically defined
      population is described. Provision was made by means of a prescreening survey to
      determine demographic and attitudinal characteristics in the group invited to
      screening before the invitation was extended, thus providing information on non
      participants as well as participants. Men who satisfied the criteria for
      borderline levels of one or more of the three risk factors on at least two of
      possible three occasions were invited to participate in a radomized multifactor
      treatment trial either being treated by medication for the appropriate risk
      factor [or factors], or observed during the same intervals in the same fashion as
      those treated. During follow-up attempts were made to measure adherence to the
      prescribed medication.

PMID- 1022407
TI  - The renin-angiotensin systems in adrenal-regeneration hypertension.
AB  - Adrenal regeneration hypertension [ARH] was induced after Ingle and Higgins, and
      Skelton in 13 female Wistar rats one and a half months old with the purpose of
      studying the function of the renal and the brain renin-angiotensin systems in
      that model of hypertension, before and after treatment with antihypertensive
      prostaglandin EI [PGEI]. It was found that a 30 days' application of PGEI induced
      a regression of the regenerated adrenal cortex, accompanied by a significant
      decrease in arterial blood pressure to normotensive values. Plasma renin activity
      did not correlate with the level of the blood pressure nor with kidney renin
      activity and was not influenced by PGEI. However renal renin activity, which was
      found to be increased, corresponded to the elevated blood pressure, and decreased
      almost to normal values with normalization of the blood pressure. A correlation
      between the brain and kidney renin systems was established in that increased
      renal renin activity was accompanied by low brain stem and medulla renin
      activity. The balance was restored by PGEI, which not only lowered blood pressure
      and decreased renal rein acitivity, but induced an increase of brain stem and
      medulla renin activity. It is concluded that there exists a notable connection
      between adrenal cortex regeneration, renal antihypertensive prostaglandins and
      the kidney and brain renin-angiotensin systems, which pays a correlated role in
      the mechanism of adrenal regeneration hypertension.

PMID- 1022408
TI  - Hospital prognosis of myocardial infarction with respect to risk factors.
AB  - Out of 9922 patients with ischaemic heart disease [IHD] hospitalized during a
      decade, clinico-pathological data of 796 patients with acute myocardial
      infarction [MI] were analyzed in detail. With the aid of a logico-probabilistic
      model, the author made an attempt to quantify the individual risks of the
      hospital prognosis of MI and to obtain the so-called cumulative risk of MI. The
      prognostic relevances of the characters investigated were tested by Bayes'
      theorem. By reducing the matrix "character-disease", the original number of 201
      characters was reduced to 34, which were divided into five classes, as follows:
      a] anamnestic data about the occurrence of risk factors, b] data on coronary
      pains, c] objective clinical, electrocardiographic, or roentgenological findings,
      d] duration of the praehospitalization phase, e] patient's sex and age. The
      cumulative risk [sum of partial risks] amounted to 60% and less in MI with a
      favourable hospital prognosis [that is, at lethality lesser than 5%]; to 61%-
      100% with a medium fair hospital prognosis [at lethality from 6% to 30%], and to
      more than 101% with a poor hospital prognosis [at lethality of 41% and higher]. A
      comparative test of the prognostic index, performed in a different referral area,
      showed a relatively good practical usability of the criteria described.

PMID- 1022409
TI  - The effect of furosemide stimulation on renin secretion and its application in
      examining activity of the renin-angiotensin system.
AB  - The response of plasma renin concentration [PRC] to Furosemide administration and
      orthostasis stimulation was studied in 9 healthy volunteers and in 30 patients
      with essential hypertension. The results indicate that Furosemide is unfit for
      stimulation of renin secretion owing to a relatively high frequency of
      paradoxical PRC decreases observed both in hypertensives and normotensives. On
      the other hand, orthostasis stimulation is a manoeuvre suitable also for
      screening of low renin hypertension.

PMID- 1022410
TI  - The effect of orthostasis on the I-131 clearance in the metatarsal and crural
      subcutis in patients with occlusive arterial diseases.
AB  - In 11 patients with occlusive arterial disease and severe cutaneous ischaemia,
      orthostasis procuded a significant decrease in the I-131 clearance in the distal
      crural subcutis. In the metatarsal subcutis, however, the mean clearance value
      remained unchanged on the average, and in patients with low initial clearance
      values it mostly increased.

PMID- 1022411
TI  - Age-related changes of ballistocardiogram in healthy persons.
AB  - Electrocardiographic and ballistocardiographic changes in 179 clinically healthy
      men aged 21 to 60 years are reported. Pathological changes in ECG have been
      registered with advancing age as well as changes in BCG type according to Brown's
      classification, prolongation of the distances between ECG peak R and the peaks of
      BCG waves, and a reduction of the amplitudes of BCG segments. In comparison with
      the youngest group [21 to 30 years of age] the changes described were
      statistically significant, especially in individuals in the fifth and sixth
      decades.

PMID- 1022412
TI  - Changes in blood-serum enzymes in rheumatic myocarditis.
AB  - Serum activity analyses of nine enzymes [CPK, HBDH, SDH, ALP, GPT, GOT, LDH, MDH,
      ALD] in patients with rheumaitc carditis revealed certain elevations of the mean
      values of LDH, GOT, HBDH, GPT, ALP and MDH. These changes have no particular
      diagnostic importance because similar findings were also obtained in patients
      with both rheumatic and nonrheumatic arthritis. The changes occurring during
      antirheumatic treatment are minimal and statistically not significant. Greater
      elevations of LDH, ALD, GOT, HBDH, GPT, MDH, and ALP are found in patients with
      decompensated rheumatic heart disease associated with active rheumatic carditis.

PMID- 1022413
TI  - The secretory IgA system.

PMID- 1022414
TI  - Arsenic and skin cancer: cocarcinogenicity.

PMID- 1022415
TI  - Routine screening patch test results: 1970-1974.

PMID- 1022416
TI  - Contact urticaria: a different contact dermatitis.

PMID- 1022417
TI  - Comments regarding hypoallergenic cosmetics.

PMID- 1022418
TI  - The International Contact Dermatitis Research Group.

PMID- 1022419
TI  - Immunoglobulin E, atopy, and nickel allergy.
AB  - Statements in the literature as to whether a relation exists between atopy and
      nickel allergy are contradictory. I have attempted to make the diagnosis of the
      two states more stringent by using immunoglobulin E (IgE) determinations and
      serial dilution tests with nickel sulfate. The IgE determinations proved to be of
      less value in cases of pure eczema, and nonspecific (?) increases were sometimes
      observed. The incidence of family atopy was higher in other reports, but the
      clinical significance of this was unclear. Serial dilution tests gave important
      information, and a warning is issued against uncritical acceptance of a test
      reaction with 5.0% nickel sulfate in a patient with suspected atopy.

PMID- 1022420
TI  - Guidelines for placement of elective incisions.
AB  - The scar resulting from elective cutaneous surgery can be minimized if the
      location of the incision is chosen after considering the direction of the skin
      tension lines, creases, and wrinkles, and if the patient is positioned so that
      the skin of the surgical field is in a relaxed or anatomically neutral position.
      Selection of the best location for an elective incision is discussed.

PMID- 1022421
TI  - Choroid plexus papilloma. I. Proof of cerebrospinal fluid overproduction.
AB  - Utilizing a ventricular perfusion technique, the rate of CSF formation was
      determined in a 2-year-old child before and after removal of a 74 g choroid
      plexus papilloma from the left lateral ventricle. Preoperatively, the CSF
      formation rate was 1.05 +/- SD 0.01 ml/min (1,656 ml/day). Postoperatively, the
      CSF formation rate was reduced fivefold to 0.20 +/- SD 0.01 ml/min (288 ml/day).
      Whereas these data are regarded as conclusive evidence of CSF overproduction by a
      choroid plexus papilloma, the pathogenesis of generalized ventricular enlargement
      in this case was due to part to obstruction of the subarachnoid pathways.

PMID- 1022422
TI  - Pediatric pneumoencephalography with nitrous oxide.
AB  - The recent advances in neurodiagnostic procedures have changed
      pneumoencephalography. Now we must find the smallest lesions and demonstrate
      accurately their relationships to the ventricular system cisterns and surrounding
      structures. Complex blurring motion tomography gives this detail, but the
      pediatric patients are difficult to examine and immobilization during the long
      exposure needed for tomography frequently compromises the airway. Hypoventilation
      from sedation and from the radiographic positioning may lead to increased
      intracranial pressure. By performing pediatric pneumoencephalography under
      general anesthesia, with nitrous oxide as both an anesthetic agent and as the
      contrast material, we are able to control patient motion, preserve the child's
      airway, and prevent hypoventilation. The nitrous oxide, rapidly diffusible, is a
      good contrast agent, as large volumes can be used and the gas leaves the
      ventricular system quickly after the discontinuation of the anesthetic. This
      rapid reabsorption and elimination of the subarachnoid gas may decrease
      pneumoencephalographic morbidity.

PMID- 1022423
TI  - Multiple arteriovenous malformations of spinal cord and brain in a child. Case
      report.

PMID- 1022424
TI  - Experimental congenital hydrocephalus. A review with special consideration of
      hydrocephalus produced by zinc deficiency.
AB  - A review was made of experimental methods available to produce congenital
      hydrocephalus by teratogenic methods. Radiation, infections, trypan blue,
      hypervitaminosis A, salicylates and nutritional deficiencies were considered. In
      the course of prenatal zinc deficiency experiments, congenital hydrocephalus was
      frequently encountered and histologic sections were made of many representative
      specimens. Details of the findings are described, among them various types of
      aqueduct stenosis or obileration. Although these anomalies suggest that occlusion
      of the aqueduct is the cause of the enlargement of the ventricular system it was
      noted that there was also ventricular dilatation caudal to the stenotic point of
      the aqueduct. Hydrocephalus without aqueductal stenosis has also been observed in
      experimental animals. It seems possible that some cases of congenital
      hydrocephalus attributed to aqueductal stenosis are examples of hydrocephalus
      with secondary block of the aqueduct.

PMID- 1022425
TI  - Intraspinal lipomas in children.

PMID- 1022426
TI  - [Budd-Chiari syndrome caused by a membranous stenosis of the inferior vena cava.
      Apropos of a case treated by 1-stage caval plasty and portacaval anastomosis].

PMID- 1022427
TI  - [Preservation of the rectum in surgery for ulcero-hemorrhagic rectocolitis].

PMID- 1022428
TI  - [Icterogenic stenosis of the intrapancreatic common bile duct after closed
      epigastric injury].

PMID- 1022429
TI  - [Calibration of the pedicular common bile duct. Value of "axial exit" drainage].

PMID- 1022430
TI  - [A new colostomy device: the magnetic prosthesis. Preliminary note].

PMID- 1022431
TI  - [A particularly severe gastro-bronchial fistula].

PMID- 1022432
TI  - [Methods of studying and assessing the thromboresistance of polymeric materials].

PMID- 1022433
TI  - [Biomechanical studies and their value in assessing the suitability of vascular
      substitutes for arterioplasty].

PMID- 1022434
TI  - [Cerebral angiography in experimental coarctation].

PMID- 1022435
TI  - [Draining wound cavities using an automatic device].

PMID- 1022436
TI  - [Functional morphology of the chief human veins in light of their surgical
      treatment (according to raster electron microscopy findings)].

PMID- 1022437
TI  - [Arrest of aortic hemorrhage using external pneumatic compression].

PMID- 1022438
TI  - [Experimental embolism of the pulmonary artery and embolectomy with assisted
      circulation].

PMID- 1022439
TI  - [Intracorporeal dialysis in liver failure].

PMID- 1022440
TI  - [Sequelae of experimental wedge resection of the liver].

PMID- 1022441
TI  - [Estrogen therapy as a cause of experimental and clinical pyelonephritis].

PMID- 1022442
TI  - [Comparative assessment of free-flow and stop-flow methods of thyroid gland
      preservation].

PMID- 1022443
TI  - [Modeling a congenital defect between the aorta and pulmonary trunk].

PMID- 1022444
TI  - [Pathomorphology of the thoracic duct and accompanying nerve ganglia in
      experimental peritonitis].

PMID- 1022445
TI  - [Structural and functional changes in the small intestine in acute duodenal
      obstruction].

PMID- 1022446
TI  - [Diagnosis of internal hemorrhages by the radioisotope method].

PMID- 1022448
TI  - [Experimental invagination cholecystostomy].

PMID- 1022447
TI  - [Prevention of cicatricial narrowing in experimental free esophagoplasty].

PMID- 1022449
TI  - [Areflux method of proximal stomach resection].

PMID- 1022450
TI  - [Effect of sodium hydroxybutyrate and neuroleptoanalgesic drugs on the accuracy
      of measurement of circulating blood volume using Evans blue].

PMID- 1022451
TI  - [Diagnosis of metabolic disorders in patients in severe conditions caused by
      hypoxia].

PMID- 1022452
TI  - [Effect of general and regional anesthesia on membranes of mitochondria and the
      sarcoplasmic reticulum].

PMID- 1022453
TI  - [Effect of fluothane and methoxyflurane on renal function during the
      postoperative period].

PMID- 1022454
TI  - [Thiamine excretion and consumption of relaxants with different types of
      endotracheal anesthesia].

PMID- 1022455
TI  - [Role of local anesthesia in performing complex bronchologic studies].

PMID- 1022456
TI  - [Blood transfusion and intravenous novocaine administration in the treatment of
      acute massive blood loss].

PMID- 1022457
TI  - [Cardiac venous system of dogs following resection of the subaortic nerve plexus
      and constriction of the coronary sinus performed against a background of
      experimental myocardial infarction].

PMID- 1022458
TI  - [Experimental eversion endarterectomy].

PMID- 1022459
TI  - [Dynamics of several indices of bioenergetics in brain, liver, kidney and muscle
      tissue in experimental burn shock].

PMID- 1022460
TI  - [Comparative characteristics of the stereoultrastructure of the great vessels of
      animals and man as material for transplantation in vascular surgery (raster
      electron microscopic observations)].

PMID- 1022461
TI  - [Modeling arteriovenous fistulas of the large vessels of the limbs and
      comparative characteristics of their surgical treatment by lateral plastics].

PMID- 1022462
TI  - [Effect of a continuous action carbonate laser on the auricular concha of
      rabbits].

PMID- 1022463
TI  - [Functional state of the gastric mucosa following circular dissection of the
      serous-muscular layer of the stomach as a variant of selective vagotomy of the
      organ].

PMID- 1022464
TI  - [Morphofunctional analysis of the state of the small intestine under conditions
      of subdiaphragmatic vagotomy].

PMID- 1022465
TI  - [Active transport of glucose in the small intestine in several variants of
      surgical aggression].

PMID- 1022466
TI  - [Comparative characteristics of experimental surgery performed using a laser
      beam, electric knife and surgical scalpel].

PMID- 1022467
TI  - [Changes in intestinal peristalsis under the influence of peritoneal fluid from
      experimental intestinal obstruction].

PMID- 1022468
TI  - [Pathomorphologic characteristics of tissue and vascular changes in the pancreas
      under experimental conditions].

PMID- 1022469
TI  - [Comparative study of the preparation biloptin in experimental peroral
      cholecystography].

PMID- 1022470
TI  - [Partial hepatecomy in DDT carriers].

PMID- 1022471
TI  - [Pathogenesis of hepato-cerebral insufficiency].

PMID- 1022472
TI  - [Liver preservation by a method of artificial circulation for the cadaver].

PMID- 1022473
TI  - [Renal morphology following creation of arteriovenous anastomoses].

PMID- 1022474
TI  - [Planning reconstructive facial surgery using allogenic frozen cartilage and
      predicting the outcome].

PMID- 1022475
TI  - [Normal blood pressure in thoracic bones and changes in several pathologic
      states].

PMID- 1022476
TI  - [Our model of experimental hematogenic osteomyelitis in rabbits].

PMID- 1022477
TI  - [Value of transport immobilization for prevention of shock in closed diaphyseal
      fractures of the femur].

PMID- 1022478
TI  - [Effect of combinations of penicillins and acrichine on staphylococcal infections
      in white mice].

PMID- 1022479
TI  - [Relationship between the nuclear-cytoplasmic constant and the optical density of
      cell nuclei for characteristic conditions of an epithelial field].

PMID- 1022480
TI  - [Experimental model of recurarization after administering succinylcholine].

PMID- 1022481
TI  - [Dynamics of lactate dehydrogenase isoenzymes during surgical correction of
      congenital heart defects under conditions of hyperbaric oxygenation].

PMID- 1022482
TI  - [New principle for oxygenating blood during extracorporeal circulation].

PMID- 1022483
TI  - [Surgical treatment of the incomplete form of atrioventricular canal].

PMID- 1022484
TI  - [Comparative assessment of the energetic efficiency of the cardiac mitochondria
      of humans and experimental animals].

PMID- 1022485
TI  - [Functional disorders of valular allo- and xenotransplants in the postoperative
      period according to phonocardiographic and morphologic findings].

PMID- 1022486
TI  - [Determination of the duration of viability of aortic allo- and xeno-valves
      intended for clinical use].

PMID- 1022487
TI  - [Experimental microsurgery].

PMID- 1022488
TI  - [Concentration of cholesterol and its esters in the walls of several vessels in
      experimental coarctation of the aorta].

PMID- 1022489
TI  - [Lympho-venous anastomosis in the treatment of lymphatic edema of the lower
      extremities (clinico-experimental study)].

PMID- 1022490
TI  - [Changes in the morphology and function of the remaining lung following
      experimental pulmonectomy].

PMID- 1022491
TI  - [Effect of glycerin preservation on the immunogenic properties of dura mater].

PMID- 1022492
TI  - [Comparative assessment of experimental circular gastrotomy and selective
      vagotomy].

PMID- 1022493
TI  - [Effect of laser radiation on the mucous membrane of the stomach and features of
      its regeneration following experimental irradiation].

PMID- 1022494
TI  - [Experimental acute hepatic insufficiency].

PMID- 1022495
TI  - [Antitoxic function of the liver in mechanical jaundice].

PMID- 1022496
TI  - [External choledocho-jejunal fistula as a method of determining the exocrine
      function of the liver].

PMID- 1022497
TI  - [Elements of automation during experimental inclusion of an isolated liver].

PMID- 1022498
TI  - [X-ray method of determining the rate of iodamide absorption from the peritoneal
      cavity].

PMID- 1022499
TI  - [Use of intravascular catheterization for a simultaneous complex study of renal
      circulation].

PMID- 1022500
TI  - [Histopathologic changes in neuroglia in extensive experimental burns].

PMID- 1022501
TI  - [Experimental kidney preservation by a simplified method].

PMID- 1022502
TI  - [Changes in the hemodynamics and secretory-excretory function of the kidneys
      following experimental unilateral ureteral occlusion].

PMID- 1022503
TI  - [Osteoreception under normal conditions and in acute experimental osteomyelitis].

PMID- 1022504
TI  - [Effect of regional perfusion of a limb without tourniquet on several bodily
      parameters under experimental conditions].

PMID- 1022505
TI  - [Features of reparative regeneration following experimental osteosynthesis with
      cyanacrylates].

PMID- 1022506
TI  - [Adhesive and bacteriostatic properties of "cyacrine" glue components].

PMID- 1022507
TI  - [Relationship between separation of surgical sutures and the age of the surgical
      patient (electron microscopic examination of 47 surgical patients)].

PMID- 1022508
TI  - [Complications of blood transfusion in dogs. Role of incompatibility with regard
      to thrombocyte antigens].

PMID- 1022509
TI  - [Improvement in the detection of nuclear-cytoplasmic constants of malignant
      structures and assessment of the degree of their involvement].

PMID- 1022510
TI  - [Comparative assessment of the hemodynamic effect of peripheral and central
      contrapulsation in acute myocardial ischemia].

PMID- 1022511
TI  - [Total peripheral vascular resistance in assessing the adequacy of
      anesthesiologic assistance].

PMID- 1022513
TI  - Initial evaluation of the multiple injury patient.

PMID- 1022512
TI  - First Forum debate: Funding of pre-hospital EMS is the responsibility of the
      public sector.

PMID- 1022514
TI  - What does it take to make an auto rescue squad?

PMID- 1022516
TI  - Advanced cardiopulmonary resuscitation.

PMID- 1022517
TI  - The dentist: an overlooked resource.

PMID- 1022518
TI  - Equipment. Improving ambulance electrical systems. II.

PMID- 1022519
TI  - Communications.

PMID- 1022520
TI  - Substance P radioimmunoassay using Nalpha-tyrosyl-substance P and demonstration
      of the presence of substance P-like immunoreactivities in human blood and porcine
      tissue extracts.
AB  - Sensitive and specific radioimmunoassay for substance P was developed using
      synthetic substance P and 125I-Nalpha-tyrosyl-substance P. Substance P-human
      alpha-globulin conjugate was used for production of anti-substance P antisera in
      rabbits. Synthetic substance P was used as a standard and the dextran-coated
      charcoal method was employed to separate the free peptide from that bound to
      antibodies. No cross-reactions by physalaemin and eledoisin observed in this
      system proved its high specificity to substance P. Nalpha-Tyrosyl-substance P and
      [Tyr1]-substance P showed the displacement curves indistinguishable from that of
      the standard substance P. Neither substance P5-11 nor substance P6-11 competed
      with the tracer at the concentration used. The minimum measurable dose of
      substance P by the assay system was 2.5-5 pg/incubate. Utilizing the system,
      human plasma samples from 42 healthy volunteers of both sexes were shown to
      contain immunoreactive substance P in amounts that averaged 298 pg/ml in male and
      251 pg/ml in female. Substance P-like immunoreactivity was also demonstrated in
      hot-water extracts of porcine duodenum, jejunum, ileum, cecum, middle colon,
      rectum, pancreas, stomach and pituitary. The highest concentration (379 ng/g wet
      weight of organ) was found in the pituitary, and the ileum (7.9 ng/g wet weight
      of organ) and jejunum (1.9 ng/g wet weight of organ) were rich in the contents.

PMID- 1022521
TI  - A radioimmunoassay for human plasma corticosterone.
AB  - A radioimmunoassay for human plasma corticosterone has been developed. Antiserum
      against corticosterone was produced in rabbits immunized with corticosterone-21
      hemisuccinate conjugated to bovine serum albumin. The antiserum cross-reacted
      with progesterone, DOC and dehydrocorticosterone more than 20%. After the
      extraction with ether, and the separation by Sephadex LH-20 microcolumn
      chromatography, recovery was 51.2 +/- 12.1% in 50 assays. The mean coefficient of
      variation between assays was 7.7% and within assays was 8.6%. Human plasma
      corticosterone is measured readily by assaying aliquots of an ether extract of
      0.05 to 0.1 ml of plasma after microcolumn chromatography. The mean plasma
      corticosterone concentration at 9 a.m. was 7.1 +/- 3.2 ng/ml in 45 normal
      subjects. Plasma corticosterone increased 5.2 times as much as basal values after
      ACTH injection, whereas radioimmunoassayed cortisol increased 2.4 times. On the
      other hand, plasma corticosterone decreased to 22.6% of basal values at four
      hours after 1 mg dexamethasone, whereas radioimmunoassayed cortisol decreased to
      12.3% of basal values.

PMID- 1022522
TI  - Post-traumatic anterior pituitary insufficiency developed in a patient with
      partial lipodystrophy.
AB  - A case of partial lipodystrophy developing anterior pituitary insufficiency,
      chronic glomerulonephritis and pulmonary fibrosis was reported. The patient died
      of respiratory failure secondary to pituitary crisis during the hospital course.
      From the clinical course in recent several years and the postmortem examination
      the head injury following car accident in the past history was considered to be
      the most plausible cause of hypopituitarism. The etiology of pulmonary fibrosis
      remained unresolved.

PMID- 1022523
TI  - Studies on the "low dose" suppressible Cushing's disease.
AB  - Diagnosis of Cushing's disease in most cases can be established by the standard
      dexamethasone suppression test without difficulty. However, some cases were known
      to be normally suppressed by the standard low dose of dexamethasone (2 mg daily).
      The case we encountered recently was also normally suppressed by either the rapid
      (Nugent) or the standard (Liddle) method. This fact prompted us to study the
      usefulness of a single dose of 0.5 mg of dexamethasone to suppress the plasma
      cortisol in the normal. It was concluded that the single oral dose of 0.5 mg of
      dexamethasone given at 11 p.m. on the previous night suppressed the plasma
      cortisol efficiently the following morning in the normal, thus making the
      differentiation of particular cases of Cushing's disease from the normal
      possible. The disappearance of plasma dexamethasone did not differ significantly
      between the normal and the Cushing's disease.

PMID- 1022524
TI  - Roles of circulating carcinoembryonic antigen and calcitonin in diagnosis of
      medullary thyroid carcinoma: a comparative study.
AB  - Carcinoembryonic antigen (CEA) and calcitonin (CT) were simultaneously determined
      in sera and tumor tissues from 15 patients with medullary carcinoma of the
      thyroid (MCT). Serum CEA was increased in all but one patient, and CT did in all
      of them. Both levels were significantly related to the weight of excised tumor,
      but not to the presence of metastasis. Furthermore, a significant correlation was
      noted between the basal levels of CT and CEA. Both levels fell to normal after a
      radical operation had been performed. Tissue concentrations of CEA and CT in the
      MCT were more than 100 times those in hyperthyroidism, and the ratios of tissue
      over serum levels averaged 770 in CEA and 1000 in CT. In the calcium infusion
      test, CEA levels were not significantly changed in contrast with a distinct
      increase in CT levels. The results indicate that CEA and CT represent separate
      activities of the tumor cells, and that circulating CEA together with CT is a
      useful indicator in the diagnosis and follow-up of the disease.

PMID- 1022525
TI  - Purification and properties of whale thyroid-stimulating hormone III. Properties
      of isolated multiple components.
AB  - Properties of the four purified components of whale thyroid-stimulating hormone
      (TSH) have been compared. The amino acid composition shows close similarity among
      these components. Their hexosamine and sialic acid contents are of the same
      magnitude, whereas the neutral sugar composition differs somewhat from each
      other. The molecular weight of whale TSH determined by sedimentation equilibrium
      is 29,000, and no difference in molecular weight as well as in Stokes radius as
      determined by gel filtration has been detected among these four components. The
      amino acid and carbohydrate compositions of whale TSH resemble those of TSH from
      other species, especially those of non-primate mammalian TSH. Whale TSH contains,
      unlike bovine TSH but like human TSH, 1-2 residues of sialic acid as a
      constituent carbohydrate.

PMID- 1022526
TI  - Fetal rat adrenal steroidogenesis and steroid transfer to adrenalectomized
      mother.
AB  - On the 22nd day of gestation in rats, fetuses of acutely adrenalectomized mothers
      were injected subcutaneously with 0.43 muCi 4-14C-progesterone in 0.05 ml saline.
      Ten and 20 min after injection to fetuses, samples were taken to determine the
      14C-progesterone metabolites in the plasma and adrenal glands. After extraction
      of the samples taken, the metabolites were separated by two-dimensional thin
      layer chromatography and identified by autoradiography. 11-deoxycorticosterone,
      18-hydroxy-11-deoxycorticosterone, corticosterone and 11beta-hydroxyprogesterone
      were identified in the plasma of injected fetuses, and, in far smaller amounts,
      in the plasma of their mothers. The plasma of noninjected fetuses also contained
      very small amounts of these corticoids. The fetal adrenal glands contained far
      smaller amounts of radioactive steroids than the fetal plasma did. The results
      obtained show that steroids of fetal origin can cross the placenta in and out,
      constituting evidence that the fetal adrenal glands are the only source of the
      plasma corticoids of their adrenalectomized mothers.

PMID- 1022527
TI  - Variety of GH and TSH responses to somatostatin in perfused rat pituitaries in
      vitro.
AB  - One male rat pituitary placed in a chamber was perifused with cyclic somatostatin
      (GIF) for 30 min. Either 160 nM or 1.6 muM GIF caused a decrease in the release
      of GH. The release of TSH was also decreased by 160 nM GIF, and paradoxically
      increased by 1.6 muM GIF. Increasing the dose of GIF to 16 muM resulted in an
      abrupt rise in the release of both GH and TSH during the perfusion; then the
      level of GH decreased to the nadir level followed by an elevation above the base
      line, while that of TSH promptly fell back toward the base line. The release of
      PRL was not clearly affected by 16 muM GIF. [Tyr8]-GIF did not have such
      stimulatory activities. These results indicate that GIF not only inhibits the
      release of GH and TSH, but also stimulates that of GH and TSH in this system,
      depending on its dose.

PMID- 1022528
TI  - [Chemical heterogenicity of the synaptic organization of different regions of the
      rabbit cerebral cortex].
AB  - In anesthetized rabbits, visual EP was recorded in the temporal cortex, and EP
      elisited by stimulation of the n. ischiadicus--in the somatosensory cortex.
      Application of 1% GABA, glycine, and nembutal solutions to the site of EP
      recordings increased the visual EP and diminished the somatosensory EP. The data
      obtained seem to corroborate the chemical heterogeneity of synaptic organizations
      of the visual and somatosensory cortex in the rabbit brain.

PMID- 1022529
TI  - [Neuronal responses in the sensomotor and orbital cortex of the kitten brain].

PMID- 1022530
TI  - [Cerebral cholinesterase under conditions of a generalized convulsive seizure].
AB  - The activity of acetylcholinesterase and butyrilcholinesterase was studied during
      prolonged seizures developing from a primary-cortical focus. The activity was
      found to spread both along the wide limbic system, which indicates to
      participation of cholinergic agents in processes of "recurrent generalization" of
      excitations, and along the horizontal system of fibers connecting both
      hemispheres. This latter finding indicates to participation of cholinergic
      mediatory mechanisms in formation of seizures.

PMID- 1022531
TI  - [Background activity of neurons of the lateral hypothalamus in hungry and fed
      rabbits].

PMID- 1022532
TI  - [Recovery of function following incomplete section of the posterior funiculi of
      the spinal cord].
AB  - The course of functions recovery and the changes of somatosensory cortical evoked
      potentials were studied in cats after incomplete dorsal funiculi section at the
      cervical level. The restoration of functions was more rapid and complete in
      animals with the partial section as compared with those with complete dorsal
      funiculi section. The latter had no evoked potentials recovery. Undamaged fibers
      were concluded to be able to send a significant afferent inflow from the
      periphery to the cortical somatosensory areas and, apparently, to play an
      important role in the process of the compensatory reorganisation.

PMID- 1022533
TI  - [Assessment of the thermal effect of a current on the brain during stimulation
      with an implanted electrode].

PMID- 1022534
TI  - [Role of cholino- and adrenoreceptors in regulating blood coagulation and
      fibrinolysis following thrombin injections].

PMID- 1022535
TI  - [Effective of surgical decortication on cardio-cardiac reflexes in cats].
AB  - The cardio-cardiac reflexes were studied in unanesthetized curarized cats before
      and after surgical decortication. The data obtained showed three varieties of the
      cortical adaptation: the inhibition of the reflexes, their facilitation, and the
      effects of regulatory "silence". Under normal condition the cortical function
      seems to exert modulating influences on the cardio-cardiac reflexes by way of the
      afferent vagal nucleus.

PMID- 1022536
TI  - ["Tracking" the magnitude of arterial pressure in the circulatory system].
AB  - Steady--state characteristics of arterial and venous pressure, cardiac output,
      total peripheral resistance, heart rate, and pumping heart capacity depending on
      blood volume change were studied in dogs under conditons of rest, exercises,
      light and deep narcosis. The tracking mean arterial pressure was found to be the
      main principle of hemodynamic regulation. In unanesthetized animals the tracking
      is based on heart regulation component mainly, while under light narcosis it is
      the vascular component. In deep narcosis it is the suppressed tracking principle:
      arterial pressure change is proportional to blood volume changes.

PMID- 1022537
TI  - [Relationship between respiratory volume and duration of inspiration in
      decerebrate cats].
AB  - In decerebrated cats, tidal volume (Vt) was increased from apnoea to maximal
      values in result of rebreathing. In most cases there was a reversed relationship
      between Vt and inspiratory duration (Ti). The shape of curves was nearly the same
      before and after vagotomy. The curves consisted of three parts. The relationship
      between Vt and Ti is primarily determined by bulbopontine respiratory mechanism.
      Impulses from pulmonary stretch receptors shift Vt--Ti relationship curve to the
      left and down.

PMID- 1022538
TI  - [Analysis of the relationship between pulmonary volume and the rate of pulmonary
      stretch receptor discharge in cats].
AB  - The "frequency of discharges vs. lung volume" ratio could be either linear (25
      fibers, 24%), or breaking to linear pieces (24 fibers, 23%), or nonlinear (57
      fibers, 53%). The nonlinear ratio was approximated with equation f=KVn+C, where f
      - frequency of discharges, V - volume of lung inflation, K and C - constant, the
      total less than 1. Afferent output from pulmonary stretch receptors increases in
      linear proportion to the volume of lung inflation.

PMID- 1022539
TI  - [Role of extravagal reflexes in regulating diaphragmatic excitation following
      tracheal occlusion and changes volume of the thoracic cavity in cats].
AB  - Decerebrated vagotomized cats after tracheal occlusion developed a slight but
      significant decrease in duration of inspiration, respiratory cycle, and in
      amplitude of diaphragmatic nerve ENG. Deflation (10-30 ml) or inflation (20-60
      ml) of the lungs produced no changes in activity of diaphragmatic motorneurons. A
      stronger inflation (80-100 ml) decreased the expiratory phase activity. After
      bilateral vagotomy only slight and inconstant changes of respiratory rhythm were
      observed.

PMID- 1022540
TI  - [Characteristics of the motor activity of the stomach according to cutaneous
      electrogastrographic and balloon mechanographic findings].
AB  - Slow electrical potentials recorded from the stomach projections on extremities
      in dogs seems to be, in fact, the electrogastrogram reflecting major electrical
      events in different portions of the stomach. No constant correlation was revealed
      between the mechanical and electrical activities of the stomach. The
      electrogastrogram, being an expression of electrical activity of the smooth
      muscles of the stomach wall, can be permanently recorded, keeping at that a
      constant rhythm while changing its amplitude within comparatively narrow limits.
      The mechanogram, only reflecting coordinated contractions of the stamch muscles,
      is quite variable both in its amplitude and in the number of actual contractions.

PMID- 1022541
TI  - [Effect of adrenocortical insufficiency on the motor activity of the gall
      bladder].
AB  - In chronical experiments on dogs, blocking of glococorticoidal function of
      adrenal cortex O, pI -- DDD decreases the gall bladder motility. Disorders of
      mineralcorticoid activity of adrenal cortex leads to an increase of the motility.
      Administration of hydrocortisone and 1% solution of sodium chloride aids to
      normalize the gall bladder motility in animals with adrenal insufficiency.

PMID- 1022542
TI  - [Work capacity of skeletal muscles and energetics of muscular work during
      adaptation to cold].
AB  - After the cold adaptation muscle contraction and the working capacity decreased.
      However, the muscles of the adapted to cold rats are able to save the initial
      power for a longer time. The muscular work of adapted to cold rats involves a
      greater expenditure of energy as compared with the control rats. Changes of the
      working capacity of skeletal muscles in control rats after noradrenalin
      administration are similar to those occurring in adapted to cold rats.

PMID- 1022543
TI  - [Contractile function of the mammary myoepithelium].

PMID- 1022544
TI  - [Rate of lymph flow and lymph transport of free amino acids in the thoracic duct
      of newborn calves].

PMID- 1022545
TI  - [Method of automated control for an electrophysiologic experiment].

PMID- 1022546
TI  - Relevant health and nutrition education.

PMID- 1022547
TI  - Food additives and health: a challenge for nutrition educators.

PMID- 1022548
TI  - Emergency assistance: the nature and organization of disaster relief.

PMID- 1022549
TI  - The liver plasma membrane as a functional mosaic.

PMID- 1022550
TI  - Organization of the kidney proximal-tubule plasma membrane.

PMID- 1022551
TI  - Pyruvate carboxylase: Effect of acetyl-coenzyme A on the second partial reaction.

PMID- 1022552
TI  - The effect of hypoglycin on some parameters of glucose metabolism in the rat.

PMID- 1022553
TI  - A thin-layer-chromatographic method for the separation of sugar phosphates.

PMID- 1022554
TI  - Purification and properties of phosphoenolpyruvate carboxylase from a
      crassulacean plant Bryophyllum fedtschenkoi.

PMID- 1022555
TI  - Carbohydrate metabolism in Chinese-hamster cells.

PMID- 1022556
TI  - Reversible (near-equilibrium) reactions and substrate cycles.

PMID- 1022557
TI  - Effects of tryptophan on gluconeogenesis in the rat and the guinea pig.

PMID- 1022558
TI  - Human hexokinase isoenzymes of muscle in health and disease.

PMID- 1022559
TI  - Multiple forms of hepatic glucokinase.

PMID- 1022560
TI  - Properties of the isocitrate synthase system from rat liver.

PMID- 1022561
TI  - The influence of acetate on matrix-bound creatine kinase.

PMID- 1022562
TI  - Liver sinusoid surface membranes and glycoprotein secretion.

PMID- 1022563
TI  - Re-examination of the molecular weight of chymotryptic inhibitor I from potatoes.

PMID- 1022564
TI  - Haem biosynthesis and hydroxylation of phenazone during lead intoxication.

PMID- 1022565
TI  - The effect of 4-ethyl-5-hydroxy-3,5-dimethyl-delta3-pyrrolin-2-one on porphyrin
      synthesis in the rat.

PMID- 1022566
TI  - Effect of phenobarbitone and indoxyl sulphate on biliary excretion of foreign
      organic compounds during administration of carbon tetrachloride.

PMID- 1022567
TI  - Inhibition of human placental oestradiol-17beta dehydrogenase by adenosine
      triphosphate: the importance of the coenzyme.

PMID- 1022568
TI  - The effect of perphenazine treatment on testosterone metabolism by established
      rat mammary carcinomas.

PMID- 1022569
TI  - Binding of bile acids to 100000g supernatants from rat liver.

PMID- 1022570
TI  - The protein content of the magnum of the domestic fowl in relation to the
      secretion and synthesis of albumin.

PMID- 1022571
TI  - Constitutivity of the mandelate enzymes in Acinetobacter calcoaceticus, N.C.I.B.
      8250, and its effect on the synthesis of benzyl alcohol dehydrogenase.

PMID- 1022572
TI  - The protomer isoinhibitors of chymotryptic inhibitor I from potatoes.

PMID- 1022573
TI  - A model system for measuring enzyme reactions under conditions of water
      limitation comparable with those existing in unimbibed resting seeds.

PMID- 1022574
TI  - A radioimmunoassay for chromosomal proteins.

PMID- 1022575
TI  - The relationship between cod egg protein and its precursor.

PMID- 1022576
TI  - The importance of changes in membrane transport in lymphocyte activation by
      phytohaemagglutinin.

PMID- 1022577
TI  - The mechanism of mitochondrial maturation in the liver of the perinatal rat.

PMID- 1022578
TI  - Evolutionary conservation of methylated sequences in vertebrate nuclear
      deoxyribonucleic acid.

PMID- 1022579
TI  - Comparative aspects of ribosome-membrane interactions in rat liver and brain
      cortex in vitro.

PMID- 1022580
TI  - Developmental changes in brain-specific enolase isoenzymes.

PMID- 1022581
TI  - Evidence for the existence of a proteoglycan in sheep brain.

PMID- 1022582
TI  - Copper and caeruloplasmin in schizophrenia.

PMID- 1022583
TI  - The kinetics of human erythrocyte acetylcholine hydrolase before and after
      solubilization with Triton X-100.

PMID- 1022584
TI  - Analytical subcellular fractionation of jejunal biopsies from human subjects.

PMID- 1022585
TI  - The biosynthesis of rat serum apolipoproteins by liver and intestinal mucosa.

PMID- 1022586
TI  - Biochemical studies on anaemia of pregnancy.

PMID- 1022587
TI  - Acyl-coenzyme A thioesterase activities in lactating mammary gland of the rabbit.

PMID- 1022588
TI  - Precocious stimulation of hepatic 'malic' enzyme activity in ovo following a
      pituitary graft.

PMID- 1022589
TI  - Evidence for the release in vitro of iodothyronine deiodase activity from normal
      human thyroid cells.

PMID- 1022590
TI  - Isotopic exchange studies on the type-L pyruvate kinase from pig liver.

PMID- 1022591
TI  - Substrate inhibition of pyruvate kinase isolated from the leg muscle of Carcinus
      maenas.

PMID- 1022592
TI  - Changes in protein biosynthesis and enzyme activities during erythroid-cell
      differentiation.

PMID- 1022593
TI  - Biosynthesis and metabolism of polyamines and S-adenosylmethionine in the rat.

PMID- 1022594
TI  - The usefulness of 'futile cycles'.

PMID- 1022595
TI  - The use of [14C,3H] glucose in the study of so-called 'futile cycles' in liver.

PMID- 1022596
TI  - [Transfer factor : factor of transfer of the cell-mediated immunity].

PMID- 1022597
TI  - [Urinary excretion of microproteins during essential arterial hypertension].

PMID- 1022598
TI  - [Epidemiological study on intestinal inflammatory diseases in the Province of
      Bologna].

PMID- 1022599
TI  - [Rehabilitation of the patient with myocardial infarct].

PMID- 1022600
TI  - [Effects of treatment with clofibrate on insulin response to venous overload with
      glucose].

PMID- 1022601
TI  - [Blood lipid patterns in a population over 65 years of age in the Val d'Aosta
      area].
AB  - In a sample selection of 263 elderly male and female Valdostan subjects, the
      serum lipid pattern was studied. Cholesterol, triglyceride and lipoprotein serum
      concentrations have been analized. The hyperlipoproteinaemias found were
      classified according to Fredrickson and Levy. Both the apparently primitive
      hyperlipoproteinaemias as well as those of a secondary type were found to be type
      IIa, IIb and IV with a prevalence of IIb type in both sexes.
      Hyperlipoproteinemias were found more frequently in the younger groups with a
      prevalence in the female subjects. The mean values of serum cholesterol were 211
      +/- 45 mg % in the males and 235 +/- 42 mg % in the females; the mean
      triglyceridemia was respectively 121 +/- 52 mg % and 149 +/- 70 mg %. Sex
      differences were statistically significant. The results confirm previous findings
      concerning the increase of blood lipids in females, after the V decade.

PMID- 1022602
TI  - [A histo-cytological contribution to the knowledge of atrial internodal
      connections (author's transl)].
AB  - The problems, still widely discussed, concerning the demonstration of specific
      internodal conducting pathways in the right atrium have been reviewed, in the
      light of histo-cytological findings on the initial tracts of Bachmann's
      (anterior) and Thorel's (posterior) bundles in 7 human hearts. The evidence of
      Purkinjan cells and of small myocytes, together with the richness in connective
      tissue and nervous component, make these tracts clearly distinguishable from the
      common myocardium and seem to substantiate the thesis of morphologically discrete
      internodal connections.

PMID- 1022603
TI  - [Tachycardia caused by sinus-node and atrial re-entry with associated depression
      of A-V conduction].
AB  - The authors report two clinical cases (one with WPW syndrome) of paroxysmal
      supraventricular tachycardia caused, in one case, by sino-atrial node or
      perisinusal nodal tissue re-entrance and in the other case by re-entry in the
      lower atrium and the high part of the A-V node junction. Both present A-V node
      Wenckebach periodism, which can be distinct from reciprocating tachycardias,
      through an anomalous pathway or within the A-V node, which have a typical A-V
      conduction in the ratio of one to one. But A-V node Wenckebach periodism makes it
      hard to differentiate between reciprocating and ectopic atrial tachycardias, as
      the latter often has an A-V block. The effects of two antiarrhythmic drugs
      (Verapamil, Amiodarone) on echo-zone duration, on initiation and on prophylactic
      long-term treatment of paroxysmal tachycardias are also reported and discussed.

PMID- 1022604
TI  - [Infections in pacemaker carriers (author's transl)].
AB  - Of 2243 cardiac pacemakers implanted at the cardio-surgical centre of the
      surgical clinic in the University of Padua, 150 cases of infection were observed,
      mostly caused by a delayed cutaneous decubitus from the electrode or the battery.
      The main causes for infection in pacemaker carriers and the most suitable means
      for their prevention are discussed.

PMID- 1022605
TI  - [Correlations between plasmatic concentrations and antiarrhythmic effect of
      bunaphtine (author's transl)].
AB  - Antiarrhythmic effect of Bunaphtine (1.5 mg/kg) (e.v. in 2 min) was studied in 35
      patients with ectopic rhythms, both ventricular and supraventricular. Arrhythmia
      was checked by continuous electrocardiographic recording. Bunaphtinemia was
      determined by spectrophotometric method. Plasma concentration levels proved that
      Bunaphtine is cleared from the blood in two different stages: T1/2alpha = 0.5 min
      and T1/2beta = 84.7 min. Antiarrhythmic effect was observed in connection with
      the fast distribution phase and it was even more evident when plasma
      concentration fluctuated around 3-4 mg/l. Extrasystoles increased when Bunaphtine
      levels diminished. The minimum effective level showed fairly good individual
      differences. In three cases with congestive heart failure, hepatic and renal
      insufficiency the increase or the appearance of ventricular extrasystole was
      related to high Bunaphtinemia levels. Risk of toxicity seems to be related to the
      dose and the administration methods. Cardiac decompensation or hepatic and renal
      insufficiency determine more elevated and protracted Bunaphtinemia levels.

PMID- 1022606
TI  - [Reconstruction of the pulmonary outflow tract with a valved conduit (author's
      transl)].
AB  - The authors describe 25 patients who underwent open heart surgery for
      reconstruction of the pulmonary outflow tract with a valved conduit. The
      following anomalies were observed: six cases of great vessels transposition, five
      cases of pulmonary artery atresia, five cases of truncus, three cases of
      tetralogy of Fallot and six cases of single ventricle. Two cases of single
      ventricle were treated in order to be transformed into a systemic ventricle. The
      pulmonary outflow was reconstructed with a valved conduit anastomosed between
      right atrium and pulmonary artery. This study includes pre- and postoperative
      hemodynamic values, surgical evaluation and a 5-months to 3-years follow-up. The
      authors emphasize that it is important that the surgical indications are closely
      related to the morphology and hemodynamics of pulmonary circulation for a better
      result.

PMID- 1022607
TI  - [The vectorcardiogram of Fallot's tetralogy in the first two years of life.
      Qualitative and quantitative analysis (author's transl)].
AB  - 36 patients, less than two years old, affected by Fallot's tetralogy were studied
      by vectorcardiography. The configuration of the QRS loop in the three orthogonal
      planes, the voltage of the 0.10 sec spatial vector, RMSV and LMSV vectors, and
      their azimuth and elevation were evaluated. Such data have been correlated to
      arterial oxygen saturation. Qualitative analysis showed a clockwise or figure
      eight QRS loop on the H and F planes in the great majority of cases; and only in
      a counterclockwise loop on the H plane was the suspicion of an arterial oxygen
      saturation greater than 85% especially in cases older than two months. The
      terminal forces of the QRS loop on the H plane were always directed under the O
      point, Whereas in the valvular pulmonary stenosis, terminal forces are generally
      superior to the O point. Quantitative analysis demonstrated the constant increase
      of the RMSV and the direct relationship of the LMSV to arterial oxygen
      saturation, and so it was the principal parameter for evaluation of the left
      ventricular volume and the size of pulmonary flow and the degree of pulmonary
      stenosis. The relationship between the azimuth of 0.01 sec spatial vector to O2
      saturation was highly significant, showing a progressive anterior development of
      the former, as the latter increased.

PMID- 1022608
TI  - [Use of bidimensional echocardiography in the diagnosis of cyanotic congenital
      heart diseases (author's transl)].
AB  - The introduction of bidimensional echocardiography in the diagnosis of congenital
      heart diseases is a most promising application of ultrasounds yielding
      significant information in their anatomical "format". 16 cases of cyanotic
      congenital heart diseases were studied by an ecg-stop action technique and the
      results are presented and discussed.

PMID- 1022609
TI  - [A new echocardiographic detection technique of the pulmonary valve (VP) in
      patients with cor pulmonale chronicum (CPC) (author's transl)].
AB  - In this paper, a new echocardiographic detection technique of the VP in patients
      with CPC is described. Subjects who frequently have large, barrel chests, with
      pulmonary emphysema and markedly depressed diaphragms, are very difficult to
      examine echocardiographically. By this technique, however, the authors obtained
      the highest detection rate so far reported (congruent to 100% of the patients
      studied). Moreover, the echocardiographic findings are validated by an ultrasonic
      anatomy study based on the use of Cardio Green (V.I.) as contrast agent.

PMID- 1022610
TI  - [Study of normal left ventricular volume (author's transl)].
AB  - A study of left ventricular volume was carried out on ten normal subjects. The
      average values and the standard deviations of the end-diastolic (EDV) and end
      systolic volumes (ESV), the systolic throw and the ejection (EF) are reported.
      They were obtained by using the single-plane cineventriculography method in the
      OAdx projection of 30 degrees.

PMID- 1022611
TI  - [Isolated T wave electrical alternans in man (author's transl)].
AB  - A case of electrical T wave alternans without change of P wave and QRS complex is
      reported here. Literature on this subject is reviewed. It is emphasized that the
      alternation of T wave always exists when important morphological anomalies of QT
      tract and prolongation of QT are present.

PMID- 1022612
TI  - [Idiopathic aneurysm of the left ventricle. Report of two cases and review of
      literature (author's transl)].
AB  - Two cases of left ventricular aneurysm occurring in young patients (23 and 29
      years respectively) are reported. Coronary arteriograms were normal. Pertinent
      literature was reviewed. About 70 cases of left ventricular aneurysm in patients
      under 35 years of age have been reported: approximately half of them are
      congenital. They include both diverticuli of the apex, as a part of a syndrome of
      congenital defects, and those, much rarer, following myocardial infarction in
      children with anomalous origin of coronary arteries. A few cases may be
      attributed to trauma or myocarditis. In 26 patients, including the two reported
      here, etiology was uncertain (idiopathic aneurysm of the left ventricle) in as
      much as malformation or an infectious disease might have been the underlying
      cause.

PMID- 1022613
TI  - [Patent double aortic arch and congenital mitral insufficiency (author's
      transl)].
AB  - A case of double aortic arch with severe congenital mitral incompetence and mild
      pulmonary arteries stenosis is described. A possible embriogenetic explanation of
      the anomaly is discussed in the light of preferential foetal blood flows.

PMID- 1022614
TI  - [Indications for coronarography].

PMID- 1022615
TI  - [Incidence and outcome of fascicular blocks in the aged. Retrospective studies].
AB  - The results of a three-year follow-up study of 45 elderly subjects (mean age 79,5
      years, range 67-96 years) with left anterior hemiblock (LAH) alone or associated
      to right bundle branch block (RBBB) are reported. In the presence of isolated LAH
      no significant changes in the mortality rate were observed. The patients with
      LAH+RBBB showed an increase in mortality rate and not rarely (2 cases out of 13)
      an evolution toward a complete A-V block. The role of age as a factor influencing
      the natural history of these patients is discussed.

PMID- 1022617
TI  - [Diagnosis of fascicular or left partial block].

PMID- 1022616
TI  - [Echocardiographic studies with a multiscanner apparatus].
AB  - This technique aims at obtaining a dynamic bi-dimensional image of the cardiac
      structures, which can be directly registered on videotape and photographed with
      Polaroid cameras. It is particularly useful -- in as much as it gives
      characteristic images -- for obstructive and non-obstructive hypertrophic
      myocardiopathies, in exudative pericarditis, in tetralogy of Fallot and mitralic
      stenosis.

PMID- 1022618
TI  - [The coronary care unit and aortic counterpulsation. A protection for the
      ischemic myocardium?].

PMID- 1022619
TI  - [Prognostic value of serial determination of CPK in acute myocardial infarction
      (author's transl)].
AB  - Serial determinations of CPK enzyme were performed every 4 hours during a 72 hour
      period in 40 patients with acute myocardial infarction (AMI) admitted to the
      Coronary Care Unit in the first 6 hours (average 2.6) from the appearance of
      symptoms. The peak ratio of activity of CPK was 708 mU/ml +/- 48 E.S. as medium
      value in the whole group was reached in a medium period of 21,1 +/- 0,74 E.S.
      hours from the attack. Half value of the peak ratio activity was reached after a
      medium time of 19,1 +/- 1,0 E.S. hours. A significant statistical correlation
      between the CPK peak ratio and the prognostic index of Selvini et al. was found.
      The peak ratio resulted in 571 +/- 41 E.S. in patients with uncomplicated AMI,
      whereas in those with complications such as arrhythmias and heart failure the
      average value was 901 +/- 136 E.S. No significant correlation between CPK values
      and ST wave evolution of the ECG peak ratio of 1638 mU/ml was found; however, one
      patient who died of cardiac rupture showed a low level of 395 mU/ml. The
      diagnostic and prognostic value of the serial determination of CPK during the
      first 48 hours of a coronary attack is emphasized.

PMID- 1022620
TI  - User evaluation of housing for the elderly.

PMID- 1022621
TI  - Assessing the need for semi-dependent housing for the elderly.

PMID- 1022622
TI  - Reminiscing and ego integrity in institutionalized elderly males.

PMID- 1022623
TI  - A program for the elderly at a private psychiatric hospital.

PMID- 1022624
TI  - Marriage and remarriage rates among older Americans.

PMID- 1022626
TI  - Revenue sharing: implications for policy and research in aging.

PMID- 1022625
TI  - Significance of grandparents. Perceptions of young adult grandchildren.

PMID- 1022627
TI  - Neighborhood conditions of the aged and local government.

PMID- 1022628
TI  - Designing a training program for understanding sensory losses in aging.

PMID- 1022629
TI  - Perceived age discrimination in a sample of aerospace employees.

PMID- 1022630
TI  - Anthropology and the aged. A preliminary community study.

PMID- 1022631
TI  - Public policy issues of women in transition.

PMID- 1022632
TI  - Humanism and the humanities of aging.

PMID- 1022633
TI  - A human relations approach to problem solving.

PMID- 1022634
TI  - Toward a comprehensive information system in gerontology. A survey of problems,
      resources, and potential solutions.

PMID- 1022635
TI  - Fear of crime among the aged.

PMID- 1022636
TI  - The fear of crime and its consequences among elderly in three urban communities.

PMID- 1022637
TI  - Attitudes toward aging: increasing optimism found with age.

PMID- 1022638
TI  - Older people in adolescent literature.

PMID- 1022640
TI  - The relative impact of congregate and traditional housing on elderly tenants.

PMID- 1022639
TI  - Attitudes toward aging and behaviors toward the elderly among young people as a
      function of death anxiety.

PMID- 1022641
TI  - A senior center in public housing for the elderly.

PMID- 1022642
TI  - Quality of care in old age institutions.

PMID- 1022643
TI  - A discount program for older persons: a limited method for extending income.

PMID- 1022644
TI  - Aging in America toward the year 2000.

PMID- 1022645
TI  - Institutional origins of articles in The Gerontologist: 1961-1975.

PMID- 1022646
TI  - The Goodmayes psychiatric service for old people.

PMID- 1022648
TI  - [Persistent fetal circulation syndrome].

PMID- 1022647
TI  - [Hepatic portoenterostomy for biliary atresia].

PMID- 1022649
TI  - [The ectopic ureter].

PMID- 1022650
TI  - [New trends in the treatment of hypoparathyroidism].

PMID- 1022651
TI  - [The future as an academic discipline].

PMID- 1022652
TI  - [Dangers of total hip replacement].

PMID- 1022654
TI  - [Hyperthyroidism and the sympathetic nervous system].

PMID- 1022653
TI  - [Prognosis and treatment of Legg-Calve-Perthes' disease].

PMID- 1022655
TI  - [The role of zinc in growth and development].

PMID- 1022656
TI  - [Photochemotherapy in psoriasis].

PMID- 1022657
TI  - [Health preservation and preventive medicine].

PMID- 1022658
TI  - [Renal regulation of uric acid metabolism in diabetes].

PMID- 1022659
TI  - [Erythropoietin in kidney diseases and several chronic diseases in children].

PMID- 1022660
TI  - [Effect of propranolol on carbohydrate metabolism of the heart muscle in
      experimental hyperthyroxinemia].

PMID- 1022661
TI  - [Indices of acid-base equilibrium in blood and the urinary excretion of hydrogen
      ions in nephrotic syndrome in children].

PMID- 1022662
TI  - [Apex cardiography in hypertensive disease].

PMID- 1022663
TI  - Recent trends in malposition terminology: a way out of semantic confusion.

PMID- 1022664
TI  - Diagnosis and nomenclature in congenital cardiac lesions.

PMID- 1022665
TI  - Valvular heart disease and familial hyperlipoproteinaemic xanthomatosis.

PMID- 1022666
TI  - Role of glucose and insulin in the management of congestive heart failure (a
      preliminary communication).

PMID- 1022667
TI  - Left ventricular filling pattern in constrictive pericarditis.

PMID- 1022668
TI  - A profile of sick sinus syndrome.

PMID- 1022669
TI  - Stability of bundle branch block.

PMID- 1022670
TI  - Study of urinary excretion of catecholamines in acute myocardial infarction.

PMID- 1022671
TI  - Electrophysiological studies in the syndrome of a short P-R interval and normal
      QRS complex.

PMID- 1022672
TI  - Ectopia cordis.

PMID- 1022673
TI  - Abnormal second heart sound in hypoplastic right heart complex.

PMID- 1022674
TI  - Reverse dhumti smoking in Goa: an epidemiologic study of 5449 villagers for oral
      precancerous lesions.

PMID- 1022675
TI  - High speed pneumatic drill biopsy in palapable lesions of the breast.

PMID- 1022676
TI  - Diagnostic difficulties in cardinoma of oesophagus.

PMID- 1022677
TI  - Space-occupying mediastinal masses: a clinicopathological profile.

PMID- 1022678
TI  - Histological assessment of cytologically abnormal smears.

PMID- 1022679
TI  - Dermatomic areas and the genesis of melanomas.

PMID- 1022680
TI  - Studies on histocompatibility antigens in an inbred mouse strain showing
      spontaneous mammary tumour and leukaemia.

PMID- 1022681
TI  - Serum iron and bone marrow iron stores in cases of leukaemias and lymphomas.

PMID- 1022682
TI  - Fatty acid composition of lipids from subcellular fractions of human malignant
      cervical and mouse fibrosarcoma tissues.

PMID- 1022683
TI  - Serum phosphohexose isomerase in cancer.

PMID- 1022684
TI  - Clinical dosimetry of extended field radiation in cancer cervix.

PMID- 1022685
TI  - Fibrosarcoma of the thyroid.

PMID- 1022686
TI  - Mammary liposarcoma--report of a case.

PMID- 1022687
TI  - Leiomyosarcoma of Meckel's diverticulum.

PMID- 1022689
TI  - Epidemiology of cancer in the Indian subcontinent.

PMID- 1022688
TI  - Tuberculosis of the oesophagus: a case report.

PMID- 1022690
TI  - Prevalence of skin diseases and detection of fungi of known medical importance at
      high altitude hilly areas.

PMID- 1022691
TI  - Epidermolysis bullosa (report of 7 cases in two families).

PMID- 1022692
TI  - What is the place of electron microscopy in diagnostic pathology today.

PMID- 1022693
TI  - Succinic dehydrogenase activity in leukocytes.

PMID- 1022694
TI  - Gastric carcinoma; an entity-unitary or divisible.

PMID- 1022695
TI  - Serological response and serum immunoglobulin levels in volunteers immunized with
      cholera toxin.

PMID- 1022696
TI  - Erythrocytic glucose-6-phosphate dehydrogenase deficiency at Varanasi.

PMID- 1022697
TI  - Primary amyloidosis associated with multiple malignancies.

PMID- 1022698
TI  - Pneumatosis cystoides intestinalis.

PMID- 1022699
TI  - Dyschondroplasia with haemangiomata (Maffucci's syndrome).

PMID- 1022700
TI  - Epidemiological models.

PMID- 1022701
TI  - Study of fertility pattern in a rural community.

PMID- 1022702
TI  - Use of discriminant analysis for improving treatment completion in District
      Tuberculosis Programme.

PMID- 1022703
TI  - Study of plague in West Bengal. II. Changing pattern of rodent population.

PMID- 1022704
TI  - An operational model of the District Tuberculosis Programme.

PMID- 1022705
TI  - Weight gain in pregnancy among underprivileged Bengali Hindu women.

PMID- 1022706
TI  - Demographic impact of Gujarat mass vasectomy campaigns.

PMID- 1022707
TI  - Status of smallpox in India and the achievement.

PMID- 1022708
TI  - Evolution of smallpox eradication programme in India.

PMID- 1022709
TI  - Chronic organophosphorus poisoning in pesticide workers.

PMID- 1022710
TI  - "Hepatitis "B" antigen in voluntary blood donors in Miraj area".

PMID- 1022711
TI  - Causes of death among the aged (55 year and over) in Nagpur City, 1957-72.

PMID- 1022712
TI  - Effects of rehousing of slum dwellers on the morbidity experience of pre-school
      children.

PMID- 1022713
TI  - Scarabiasis in Kerala.

PMID- 1022714
TI  - Influence of age and sex on blood pressure level in a rural population of age 20
      years and above in West Bengal.

PMID- 1022715
TI  - A processing system for elaboration of data obtained by the oxygraph.
AB  - A Data Processing System is presented to resolve some problems usually present in
      the oxygraph research. The possibility to obtain a file of data in which each
      experiment is arranged as completely as possible in the description of
      experimental conditions and the corresponding data permits the execution of some
      operations such as calculations, statistical elaborations, kinetic studies,
      research and comparation of experiments and plotting. This system may result very
      helpful in the programmation of the experiments and in the elaboration of the
      data obtained by the oxygraph technique.

PMID- 1022716
TI  - A completely enzymatic method for the determination of glycerophospholipids in
      human serum.
AB  - A simple method is reported for the determination of GPL in serum, requiring
      small amount of sample and adequate for screening of large population groups. The
      method is based on the release of glycerol portion of the phospholipid molecule
      by the combined action of phospholipase C and lipase. The glycerol is then
      determined by well established methods. The importance of screening of lecithin,
      that accounts for more than 84% of the glycerophospholipids of serum
      lipoproteins, is discussed in view of lipoprotein function and structure and in
      view of interaction between lipoproteins and plasma membranes.

PMID- 1022717
TI  - Relationships between inhibition of the tryptic and chymotryptic digestion from
      antiinflammatory agents and substrate structure [proceedings].

PMID- 1022718
TI  - Evidence and first characterization of a glucokinase in pig erythrocytes
      [proceedings].

PMID- 1022719
TI  - Simultaneous analysis of bases, nucleosides and nucleoside mono and
      polyphosphates by high pressure liquid chromatography (HPLC) [proceedings].

PMID- 1022720
TI  - Fluorogenic detection of primary amines in plant histochemistry with
      fluorescamine: a comparative study on the effects of coagulant and non-coagulant
      fixatives.
AB  - The new highly sensitive method of fluorescamine reaction for the topochemical
      detection of primary amino groups was studied as a substitude of ninhydrin
      Schiff's reaction for the localisation of total proteins in plant tissues. The
      influence of various coagulant and non-coagulant fixatives on the induction of
      fluorescamine fluorescence was examined: ethanol, formaldehyde gas and solution,
      glutaraldehyde, acrolein, osmium tetroxide, Bouin, Rossman, Clarke and Zenker's
      fluids and FMA were employed. It was found that the use of the fluorogenic method
      is conditioned by the fixative ability to keep the amino groups disposable and by
      its capability to reduce the natural autofluorescence of plant material. A
      detailed account of the fixation methodology demonstrated that non-coagulant
      acrolein and coagulant mercuric chloride are the most promising fixatives for the
      use of the fluorescamine reaction in plant histochemistry.

PMID- 1022721
TI  - Iodide, thiocyanate and cyanide ions as capturing reagents in one-step copper
      thiocholine method for cytochemical localization of cholinesterase activity.
AB  - The necessity of the presence of iodide in Cu-ThCh reaction was investigated by
      following the precipitate formation "in vitro" and by evaluating the
      ultrastructural localization of the precipitate in sympathetic ganglion cells of
      the frog and in the end-plate regions of the rat diaphragm. It was found that
      thiocyanate or cyanide is the only anion that can be substituted for iodide as
      the capturing agent in precipitation. The optimal concentration in the
      preincubation and incubation media of any one of the three anions is from 2 to 5
      mM. At a concentration below 1 mM precipitation "in vitro" is considerably
      delayed as a result of which in electron microscopy diffusion artefacts appear in
      tissue sections. The unconverted primary precipitate obtained in the presence of
      iodide had been used for ultrastructural localization of ChE activity and now
      this use has been extended to precipitates obtained in the presence of CN- or CNS
      . Better-quality localization in the presence of either one of the latter anions
      suggests that they, and particularly CN-, should be substituted for I- in the one
      step Cu-ThCh method for the cytochemistry of cholinesterases.

PMID- 1022722
TI  - Paraganglia in the urogential tract of man.
AB  - According to the earlier concept, the paraganglia of man are believed to
      degenerate during the first postnatal years after their dominance during the
      fetal period. Clinical case reports on persisting paraganglia led us to extensive
      exploration of surgical material obtained from urological and gynecological
      surgery. The formaldehyde induced fluorescence (FIF) was used for tracing the
      catecholamine containing tissues. The fluorescence intensities were recorded with
      a Leitz MPV 2 microspectrophotometer. Solitary, small paraganglia were found in
      all patients studied. They were especially frequent in the walls of the urinary
      bladder and in the connective tissue surrounding the urogenital organs. The
      intensity of the fluorescence was comparable to pharmacological standard of 10(
      2) M noradrenaline and at the same level as the FIF of human fetal paraganglia.
      All cells of the paraganglionic clusters exhibited FIF and no signs of
      degeneration could be observed. It is suggested that the paraganglia of man do
      not degenerate postnatally but persist as a remarcable catecholamine reservoir,
      which might be of physiological importance.

PMID- 1022723
TI  - Histochemical properties of spermatozoa and somatic cells. III. Depolymerization
      and extraction of DNA during Feulgen acid.
AB  - The Feulgen acid hydrolysis patterns of chromatin of different biochemical
      composition and compactness were analyzed. It was found that the purine
      extraction rate during acid hydrolysis was affected by the addition of NaCl or 2
      mercaptoethanol to the hydrolysis bath. The maximum DNA depolymerization rate was
      directly correlated to the depurination rate but the extraction rate of
      hydrolysed DNA was in addition dependent on the stability of the surrounding
      protein matrix. The results indicate that the diffusion of DNA fragments is
      partially obstructed in extremely stabilized chromatins (e.g. bull spermatozoa).
      It is assumed that the extraction pattern of DNA is mainly dependent on the size
      of the fragments which leave the chromatin by diffusion. It appears that basic
      proteins do not influence the depolymerization of DNA but there are indications
      that during certain experimental conditions the purine liberation is dependent
      upon the chromatin structure.

PMID- 1022724
TI  - On the method of Glenner for the histochemical demonstration of the monoamine
      oxidase (MAO).
AB  - The method of Glenner et al. for the histochemical demonstration of MAO activity
      was studied by means of scanning microdensitometry and discrete measurement of
      optical density (lambda=590 nm) of the liver and brain tissues sections. The
      experiments indicated that: (1) The optimal time of incubation (the thickness of
      sections is 15 mum) is 60-90 min. (2) The histochemical reaction proceeds with
      the following substrates: dopamine, noradrenalin, serotonin, and tryptamine. (3)
      Iproniazid is the best inhibitor for preincubation whereas for simultaneous
      inhibition the substrate semicarbazide is better. (4) The incubation under the
      anaerobic conditions caused a considerable decrease of the stain intensity of the
      sections. We consider these data to indicate that both the aldehydes and acids
      formed under oxidation may take part in direct reduction of NBT to diformazan.
      (5) The histochemical reaction for MAO  without substrates testifies to the
      presence of endogenous amines or other redox reactions leading to the reduction
      of NBT.

PMID- 1022725
TI  - Matrix organization: blueprint of nursing care organization for the 80s.

PMID- 1022726
TI  - Contract management: latest development in the trend towards regionalization of
      hospital and health services.

PMID- 1022727
TI  - Hospital-based ambulatory care--the wave of the future?

PMID- 1022728
TI  - Disrespect--a study in hospital relationships.

PMID- 1022729
TI  - Measuring inappropriate utilization.

PMID- 1022730
TI  - Evaluation of administrative and organizational effectiveness in hospitals.

PMID- 1022731
TI  - Political realities of capital formation and capital allocation.

PMID- 1022732
TI  - Predicting two types of hospital innovation.

PMID- 1022733
TI  - Labor-management conflict and change in a hospital.

PMID- 1022734
TI  - Puzzlement for hospital planners.

PMID- 1022736
TI  - Multiple-unit hospital systems under single management.

PMID- 1022735
TI  - Developing a system of large obstetrical services.

PMID- 1022737
TI  - House staff are students, not employees, NLRB rules.

PMID- 1022739
TI  - The case for physician involvement in governance and management.

PMID- 1022738
TI  - Drug/alcohol abuse patients and the confidentiality of medical records.

PMID- 1022740
TI  - Views from the chairman.

PMID- 1022741
TI  - How to get doctors involved in governance, management.

PMID- 1022742
TI  - Doctors on boards: survey tracks a growing trend.

PMID- 1022743
TI  - Cookbook medicine: defined but not defended.

PMID- 1022744
TI  - Student involvement in health care: the patient's perspective.

PMID- 1022745
TI  - The antitrust implications of physician walkouts.

PMID- 1022746
TI  - House staff union plans strategy for growth and survival.

PMID- 1022747
TI  - Do we really have enough physicians?

PMID- 1022748
TI  - Medical records and the patient's right to access.

PMID- 1022750
TI  - The controversy over audit methodologies.

PMID- 1022749
TI  - Physician compensation: survey shows marked increase in contractual arrangements.

PMID- 1022751
TI  - Physician-nurse relationships.

PMID- 1022752
TI  - Physician reaction to quality of care assessment by nurses.

PMID- 1022753
TI  - A model for physician participation in planning.

PMID- 1022754
TI  - Emergency department physician: man in the middle.

PMID- 1022755
TI  - Defining the scope of physician competence.

PMID- 1022756
TI  - Survey compares medical staff organization in teaching and nonteaching hospitals.

PMID- 1022758
TI  - Staff bylaws: an internal code of conduct.

PMID- 1022757
TI  - Hospital attorneys call for 'fundamental fairness' in staff discipline.

PMID- 1022759
TI  - Focal and segmental glomerulosclerosis causing nephrotic syndrome in adults.

PMID- 1022760
TI  - Renal histological changes in cirrhosis of liver (a preliminary study).

PMID- 1022761
TI  - Urinary indican excretion in cirrhosis of liver.

PMID- 1022762
TI  - Efficacy of Cope needle in pleural biopsy.

PMID- 1022763
TI  - Pancreatic diabeties in Hubli area (North Karnataka) (a preliminary report).

PMID- 1022764
TI  - Focal and segmental glomerular sclerosis-minimal or not-so-minimal
      glomerulonephritis.

PMID- 1022765
TI  - Endoscopy for haematemesis and gastric ulcer.

PMID- 1022766
TI  - Chondroectodermal dysplasia: Ellis van Creveld disease: (a case report).

PMID- 1022767
TI  - Sudden coronary death-clinico-pathological correlation.

PMID- 1022768
TI  - Diabetic state in chronic liver disease.

PMID- 1022769
TI  - Autosomal dominant spinocerebellar ataxia with slow eye movements-a common
      hereditary ataxia in Western India.

PMID- 1022770
TI  - Rheumatic heart disease-problems and promises.

PMID- 1022771
TI  - Extrapyramidal syndromes complicating neuroleptic drug therapy.

PMID- 1022772
TI  - A case of idiopathic haemolytic anaemia of cold antibody type having IgG
      specificity (a case report).

PMID- 1022773
TI  - Hypokalaemic periodic paralysis.

PMID- 1022774
TI  - Renal rumour with minor adenocarcinomatous and major osteosarcomatous components.

PMID- 1022775
TI  - [Evolution of a renal carcinoma treated with tuberculostatics].

PMID- 1022776
TI  - Critical evaluation of different x-ray methods in exploration of mediastinal
      lymphadenopathy.

PMID- 1022777
TI  - [Current radiological exploration of the lymphatic system].

PMID- 1022778
TI  - The radiological investigation of metastatic invasion of the azygos node.

PMID- 1022779
TI  - Orbital phlebography.

PMID- 1022780
TI  - Computed  tomography (c.t.) in affections of the vertebral column and of the
      spinal cord.

PMID- 1022781
TI  - [Chronic pancreatitis in an annular pancreas. A case diagnosed by means of
      endoscopic cholangio-wirsungography].

PMID- 1022782
TI  - [Action of underwater massage on the resorption of interstitial fluids].

PMID- 1022783
TI  - [The non-surgical treatment of common bacterial infections of joints (author's
      transl)].

PMID- 1022784
TI  - [Osteo-articular manifestations originating from tumours (author's transl)].

PMID- 1022785
TI  - Scintiscan evaluation of rheumatoid hands for monitoring the anti-inflammatory
      effects of drugs.

PMID- 1022786
TI  - Experimental study of finite amplitude pulsatile pressure waves in elastic tubes.

PMID- 1022787
TI  - Examination of elastic non-uniformity in the arterial system using a hydraulic
      model.

PMID- 1022788
TI  - The effects of variable mass and geometry, pretwist, shear deformation and
      rotatory inertia on the resonant frequencies of intact long bones: a finite
      element model analysis.

PMID- 1022789
TI  - A technique for joint center analysis using a stored program calculator.

PMID- 1022790
TI  - An instrumented shoe-a portable force measuring device.

PMID- 1022791
TI  - Measurements of nonhomogeneous, directional mechanical properties of articular
      cartilage in tension.

PMID- 1022792
TI  - Three-dimensional large displacement analysis of orthodontic appliances.

PMID- 1022793
TI  - Effect of bending on the axisymmetric vibrations of a spheroidal model of the
      head.

PMID- 1022794
TI  - Flexural wave propagation in discontinuous model and in vitro tibiae.

PMID- 1022795
TI  - Research in orthokeratology. Part II: Experimental design, protocol and method.

PMID- 1022796
TI  - The national health insurance debate: shifts toward reality?

PMID- 1022797
TI  - Setting the floor: a missing ingredient in an effective health policy.

PMID- 1022798
TI  - National health policy for the future.

PMID- 1022799
TI  - Citizen participation and health care: problems of government induced
      participation.
AB  - In this paper we trace the implications of some common contradictions in
      government-inspired efforts to increase citizen participation in health care
      delivery. We cover general problems of generating citizen participation, specific
      difficulties in community organization resulting when issues of health are the
      organizing focus, and the benefits that were thought to result from efforts to
      increase citizen participation in social programs in the 1960's. When programs
      focused on increased citizen participation were initiated program administrators
      attempted to maximize citizen involvement quickly by: projecting an image of
      maximal social impact; minimizing or ignoring questions of long-term fiscal
      uncertainty; projecting an image of maximal control by citizens; and projecting
      images of institutional solidarity and of experimentation and innovation. They
      tended to recruit to the staff social activists taken to be representative of the
      community (although they might not be), promising opportunities for upward
      mobility. They also tended to adopt conciliatory administrative styles in keeping
      with their experimental non-elitist orientations. These tendencies characteristic
      of the initiation phase of projects conflicted with the demands placed upon
      programs in later phases of program implementation. These demands resulted from
      later perceived needs to: evaluate programs; limit spending; counter internal
      organizational opposition; and respond to sponsors' shifting interests.
      Paraprofessionals recruited to the staff tended to lose their "community"
      orientation, and administrative style tended to focus considerably more on
      program accountability. These shifting program demands substantially account for
      what otherwise appears to be the failure of efforts to increase citizens'
      participation in health delivery programs, and, by extension, in other areas
      where the impetus for increased citizen participation comes from government
      initiatives.

PMID- 1022800
TI  - Federal health policy.

PMID- 1022802
TI  - National health insurance--policy priorities.

PMID- 1022801
TI  - The challenge of comparative health policy for political science.
AB  - After a brief review of the literature and some reflection on the state of the
      art, this paper argues that more analyses of health policy in an explicitly
      comparative perspective are needed. This conclusion is based on a discussion of
      the largely unexploited benefits that could accrue from a welding of political
      science and health services research and a consideration of a research design
      illustrating the compatibility of these two endeavors.

PMID- 1022803
TI  - Social class, political power, and the state: their implications in medicine-
      parts I and II.
AB  - This three part article presents an anlysis of the distribution of power and of
      the nature of the state in Western industrialized societies and details their
      implications in medicine. Part I presents a critique of contemporary theories of
      the Western system of power; discusses the countervailing pluralist and power
      elite theories, as well as those of bureaucratic and professional control; and
      concludes with an examination of the Marxist theories of economic determinism,
      structural determinism, and corporate statism. Part II presents a Marxist theory
      of the role, nature, and characteristics of state intervention. Part III (which
      will appear in the next issue of this journal) focuses on the mode of that
      intervention and the reasons for its growth, with an added analysis of the
      attributes of state intervention in the health sector, and of the dialectical
      relationship between its growth and the current fiscal crisis of the state. In
      all three parts, the focus is on Western European countries and on North America,
      with many examples and categories from the area of medicine.

PMID- 1022804
TI  - Health planning in the United States: an old idea with a new significance.
AB  - This paper examines major features of the National Health Planning and Resources
      Development Act of 1974 (P.L. 93-641), a piece of legislation that would
      radically restructure the health planning system of the United States. The Act
      combines several, previously uncoordinated, health planning and health resources
      development agencies into one coordinated program. The program is to consist of
      statutorily restricted federal agency which will generally oversee the operation
      of the program, a state program directed by a consumer-dominated board and a
      series of locally based, generally private, nonprofit, consumer-dominated
      corporations ("Health Systems Agencies") which will carry the bulk of the
      planning functions. The resource development portion of the act grants funds for
      a variety of programs. These include both grants and loans (at very favorable
      interest rates) for medical facilities. In addition there are funds available for
      innovative projects which hold the prospect of improving health services and
      environmental conditions within the community. The act also provides the states
      and local organizations with substantial power over a large portion of the
      allocations made under the Public Health Act and specifies the process by which
      health planning must be carried out. Each local planning agency must design a
      long range health plan for its community and prepare a one-year plan for carrying
      out portions of the health system plan. These two documents then are used to
      create State Health plans, plans for construction, modernization or conversion of
      health facilities and criteria for judging the appropriateness of health services
      offered in the local areas and in each state. The act seems to create a mechanism
      whereby the health industry could be quickly converted into a heavily regulated
      industry. This regulatory process could be implemented in conjunction with
      national health insurance or by itself.

PMID- 1022805
TI  - Abortion and the law: the impact on hospital policy of the Roe and Doe decisions.
AB  - The purpose of the article is to analyze the effect of the U.S. Supreme Court's
      abortion decisions upon the policies of hospitals in Harris County (Houston),
      Texas. The study attempts to determine the variables associated with the
      hospitals' policies prior to and following the Roe and Doe decisions and which
      variables best explain the change (or lack of change) from the first period to
      the other. The principal data source is a series of in-depth personal interviews
      with 68 key decision-makers in 36 general hospitals in Harris county. Critical
      data about the hospitals' economic status were obtained from the American
      Hospital Association's Hospitals: Guide Issue, 1972. The major findings of the
      study are as follows: (1) the Roe and Doe decisions did affect hospital policy in
      that within a year after the High Court's rulings, hospitals evidence a dramatic
      shift toward more permissive abortion policies; (2) economic variables, while not
      having much explanatory power for pre-Roe and Doe abortion policies, were
      important predictors of hospital policy and of the propensity for hospitals to
      liberalize their abortion standards after the Supreme Court decisions; and (3)
      the values, attitudes, and attributes of the individual decision-makers had much
      to do with explaining their respective hospitals' abortion policies before and
      after the Supreme Court decisions and accounted for changes in abortion policy
      from the first to the second period.

PMID- 1022806
TI  - Exploring new ethics for public health: developing a fair alcohol policy.
AB  - Alcoholism policy since the repeal of Prohibition has been largely based on the
      assumption that alcohol problems are the result of the failure of a small
      minority to "control" their drinking. Thus, in sharp contrast to the approach to
      other drug policies, the problem of alcohol abuse has been viewed as one of "bad
      users" rather than "bad substances." This regard of alcoholism has helped
      exonerate the majority of drinkers and the alcohol industry from responsibility.
      However, mounting epidemiological evidence demonstrates that a primary factor in
      rates of diseases such as cirrhosis is the per capita use of alcohol and suggests
      that alcohol problems can be controlled or reduced only if all involved in the
      manufacture, sale or consumption of alcohol accept the burdens of restrictions
      over its availability and use. This acceptance will not be forthcoming, however,
      unless the prevailing market ethic of individual responsibility and minimal
      collective obligations to protect and preserve life is replaced with a new public
      health ethic rooted in social justice. This new ethic would assign the highest
      priority to life and would stress the obligations of all citizens to share the
      burdens of reasonable restrictions over all health hazards. In this paper a new
      alcohol policy is outlined based on just and reasonable limits on the
      availability, marketing and consumption of this substance.

PMID- 1022807
TI  - [Studies on the spine density in lamina V pyramidal cells of the visual cortex in
      young and subadult rats after dark-rearing and destruction of the dorsal nucleus
      in the lateral geniculate body].
AB  - 1. Dark reared 50 days old rats have a significantly diminuished number of spines
      at the apical dendrite of the lamina-V-pyramidal cells in the visual cortex. 2.
      Likewise we could ascertain a significant diminution of spines after destroying
      the upsilateral Cgld. The topistical distribution of spine density differs in
      both investigated series. 3. The spine diminution at the apical dendrites of
      lamina-V-pyramidal cells differs in this way: pyramidal cells with thick apical
      dendrites show a weaker spine diminution than the pyramidal cells with thin
      apical dendrites. 4. Some topistical problems concerning specific afferents in
      the visual cortex are discussed.

PMID- 1022808
TI  - [Morphological studies on interneuronal relations in the feline motor cortex].
AB  - Three types of neuronal joinings in the cat motor cortex are described. The
      joinings of the 1st type (nests, barrels) consist of some pyramidal cells, apical
      dendrites of which form the bundles. The consolidation of neurons is achieved by
      means of dendro-dentritic contacts, pyramidal neuron collaterals and the
      associative transcortical afferents. The joinings of the 2nd type (distant) are
      formed with the participation of intracortical connections between the pyramidal
      and stellate neurons and are placed as concentric formation. The joinings of the
      3rd type are formed with the help of projection thalamo-cortical afferents and
      large horizontal collaterals of basket cells.

PMID- 1022809
TI  - [Comparative volumetric analysis of the main subdivisions of the brain in saurian
      reptiles].
AB  - The volumetric measure of the main subdivisions of the brain has been carried out
      on 32 species of Lizards and 3 species of Snakes. The analysis of the
      allometrical relations between the volume (the weight) of these subdivisions and
      the body weight shows firstly that the evolutionary or/and adaptative processes
      are only located at the mesencephalic and metencephalic levels. A more elaborate
      study leads meanwhile to the conclusion that anothers brain structures - pallium,
      basal areas, dorsal thalamus - are also implicated, according to the possibility
      to group the various species into taxomic units (such as family) or in another
      way; thus it has been possible to corroborate with quantitative datas the
      NORTHCUTT'S definition (1972) of the Type I (Lacertomorpha) and Type II
      (Dracomorpha) lizards; the Dracomorpha show "dynamical" structures - pallium and
      dorsal thalamus - and remind, in some degree the mammal organization. Each
      structure in each species can be expressed by the way of a relation index; like
      the encephalization index, the referrence is given by the 6 Lacertidae of the
      sample. The analysis of these indices is carried according to the legless
      condition, tree-dwelling life, vision performance and the various possibilities
      to group the species (taxonomic units such as family or another else); the
      comparison of the various indices corroborates the pecularities of the
      Lacertomorpha on the one hand and of the Dracomorpha on the other hand. The
      isoponderal percentages are calculated taking into account the allometrical
      relations and thus are better than the relative volumes commonly used. They lead
      to results previously expressed by the various relation indices. The comparison
      between Lizards and Snakes leads to the following conclusions: Snakes are less
      different among themselves than the Lizards, but the species of modern type
      (Caenophidia) are more telencephalized; they show a proper brain organization;
      meanwhile the legless condition is expressed, like in the so-called lizards, by a
      reduced cerebellar volume.

PMID- 1022810
TI  - Anatomical and experimental study of certain association fascicles in the cortex
      of the rabbit (Oryctalagus cuniculus).
AB  - 1. All lesions resulted in degeneration of the short intracortical association
      fibers in cortical layer I and of the short subcortical fibers which extended to
      the corona radiata before ending in the deeper layers of the overlying
      neopallium. 2. From all the lesions fibers were traced through the corona radiata
      to the subcallosal or the so-called superior fronto-occipital association bundle.
      This bundle had projection fibers to the orbitofrontal cortex. 3. From the lesion
      in the orbitofrontal neopallium, the orbitofrontal-pyriform connections were
      established. Such fibers coursed on the dorsal edge of the lateral olfactory
      tract and distributed to the pyriform cortex and to the nucleus of the lateral
      olfactory tract. 4. The uncinate fasciculus of man derived its name from its
      arching course from the base of the frontal lobe to the temporal lobe. Because of
      the more caudal position of the amygdala in the rabbit, the comparable fasciculus
      passed directly caudally and exhibited only slight arching. This fasciculus in
      the rabbit had the typical dorsal and ventral parts. The dorsal part arose from
      the orbitofrontal cortex to distribute to the pyriform and the temporal lobe
      cortices. The ventral portion extended into the olfactory tuberculum and the
      anterior amygdaloid area. 5. The paraventricular component of the transverse
      frontal fasciculus interconnected the neopallium with the medial part of the
      olfactory tuberculum. It had origins in the frontal and possibly in other
      neocortical areas. 6. The cingulum interconnected the medial portion of the
      olfactory tubercle, the septum, the various cingulate areas and areas of the
      neopallium with each other. 7. Therefore, the New Zealand white rabbit had short
      association fibers which were mainly neopallial in origin and termination and
      long association fibers which had both a neopallial and a limbic component.

PMID- 1022811
TI  - Maternal deaths due to haemorrhage.

PMID- 1022812
TI  - Renal injury.

PMID- 1022813
TI  - Pregnancy following removal of malignant ovarian tumour.

PMID- 1022814
TI  - Maternal mortality:.

PMID- 1022815
TI  - Study of lipids, fats and sulphydryl groups in vaginal cells during menstrual
      cycle and pregnancy.

PMID- 1022816
TI  - Neurofibroma of lung.

PMID- 1022817
TI  - Spinal vascular malformation.

PMID- 1022818
TI  - Cytohormonal and cytochemical studies in obstetrics.

PMID- 1022820
TI  - The qualitative analysis of a difference equation of population growth.

PMID- 1022819
TI  - Some basic concepts about immunoglobulins.

PMID- 1022822
TI  - On the differential equations of species in competition.

PMID- 1022821
TI  - Regulated growth in random environments.

PMID- 1022823
TI  - The qualitative dynamics of a class of biochemical control circuits.
AB  - The dynamical behavior of a class of biochemical control circuits that regulate
      enzyme or protein synthesis by end-product feedback is analyzed. Both inducible
      and repressible systems are studied and it is proven that in the former unique
      steady states are globally asymptotically stable. This precludes periodic
      solutions in these systems. A similar result holds for repressible systems under
      certain constraints on kinetic parameters and binding contants. However, when the
      reaction sequence is sufficiently long, or when a large enough number of effector
      molecules bind to each repressor molecule, repressible systems can show zero
      amplitude ("soft") bifurcations: these are predicted by Hopf's bifurcation
      theorem.

PMID- 1022824
TI  - Visual perception of rigidity of solid shape.
AB  - Organisms react to objective properties of bodies in their visual field instead
      of to the perpetually changing retinal images of those bodies. We show how such a
      faculty can be mechanized. The organism synthesizes an internal model of the
      external object, that is a bundle of expectations of how the visual input will
      transform in response to the organism's exploratory movements. We deduce the
      necessary structure of the internal model and we show how the organism can
      extract this structure from the invariant features of the sensory input
      transformations. With this internal model it is possible to predict the
      subsequent aspects (contours) of the visual object as the spatial relations of
      organism and object change.

PMID- 1022825
TI  - The effects of multiple reflex pathways on the oscillations in neuro-muscular
      systems.
AB  - A model of mammalian neuro-muscular systems described previously (Oguztoreli and
      Stein, 1975) has been extended to include multiple reflex pathways, as have been
      shown to exist in primates, including man (Milner-Brown et al., 1975). A number
      of general mathematical properties of the extended system are described. In the
      final section, using computer solutions, it is shown that the presence of
      multiple reflex pathways can effectively reduce the tendency for oscillation
      which will exist if high reflex gain were concentrated in a single pathway. High
      loop gain is desirable for good control in any negative feedback system, so the
      presence of multiple reflex pathways could improve reflex control, while limiting
      the magnitude of tremor or other unwanted oscillations in neuro-muscular systems.

PMID- 1022826
TI  - Female dominant age-dependent deterministic population dynamics.
AB  - In this paper the study of a nonlinear deterministic model of an age/sex
      differentiated population is started with a proof of existence and uniqueness of
      solution of the governing equation. We also obtain time dependent upper bounds to
      the male and female populations as well as necessary and sufficient conditions
      for equilibrium.

PMID- 1022827
TI  - Theory of the response of the limulus retina to periodic excitation.
AB  - Analytical and numerical solutions are given for several problems which arise
      from a mathematical description of inhibitory interactions in the Limulus retina.
      The theory developed here takes into account the delay in lateral inhibition and
      the gradual decay of lateral and self-inhibition. Emphasis is laid on the
      calculation of responses to excitation fields which are periodic in time and
      either spatially uniform or of traveling wave type. The analytical solutions
      given are intended to help experimenters determine the range in which certain
      linearized equations and reduced measures of excitation are useful for the design
      and interpretation of experiments. Certain of the numerical solutions obtained
      describe intrinsically non-linear effects, such as "periodic bursting" under
      constant excitation.

PMID- 1022828
TI  - The error catastrophe hypothesis and aging.
AB  - A theory of the propagation of errors in the system of enzymes translating
      genetic information into proteins developed earlier is extended to include errors
      at the transcription level. The theory is compared to other statistical theories.
      The properties are defined of the protein synthesizing machineries, especially
      those of the erroneous enzymes, which give catastrophe, stable self-replication
      containing errors, recovery from errors, etc. Experimental data are analyzed in
      light of the theory to determine the validity of the error catastrophe hypothesis
      of aging.

PMID- 1022829
TI  - Convergence of genetic compositions assuming infinite population-size and
      overlapping generations.
AB  - The assumptions for the model treated in this paper are based on a population of
      hypothetically infinite size, which has reached its optimum density within a
      limited habitat. The aim has been to derive sufficient conditions for the genetic
      composition of a population to converge to a limit if generations overlap and
      time is measured in discrete intervals. Trivially the genetic composition does
      not change if at the starting point of time the compositions within all age
      classes are the same; otherwise global convergence of the age-class distributions
      implies uniform convergence of the genetic compositions within the single age
      classes if mating takes place between at least two age-classes, or within the
      first age-class only. Excluding age-class 1 mating within one age-class only
      results in periodical change of genetic compositions.

PMID- 1022830
TI  - On a transcendental equation in the stability analysis of a population growth
      model.
AB  - We consider the rate equation n = rn for the density n of a single species
      population in a constant environment. We assume only that there is a positive
      constant solution n*, that the rate of increase r depends on the history of n and
      that r decreases for great n. The stability properties of the solution n* depend
      on the location of the eigenvalues of the linearized functional differential
      equation. These eigenvalues are the complex solutions gamma of the equation gamma
      + alpha integral of 0-1exp[gamma a] ds (a) = 0 with alpha greater than 0 and s
      increasing, s(-1) = 0, s(0) = 1. We give conditions on alpha and s which ensure
      that all eigenvalues have negative real part, or that there are eigenvalues with
      positive real part. In the case of the simplest smooth function s (s = id + 1),
      we obtain a theorem which describes the distribution of all eigenvalues in the
      complex plane for every alpha greater than 0.

PMID- 1022831
TI  - On the stability of the stationary state of a population growth equation with
      time-lag.
AB  - If in the Verhulst equation for population growth the reproduction factor depends
      on the history then the equilibrium may become unstable and oscillations and even
      non-constant periodic solutions may occur. It is shown that the equilibrium is
      unstable if the reproduction factor at time t is, up to a sufficiently large
      factor, an arbitrary average of the population densities in the interval (t-2, t
      1).

PMID- 1022832
TI  - Analysis of biochemical phase shift oscillators by a harmonic balancing
      technique.
AB  - The use of harmonic balancing techniques for theoretically investigating a large
      class of biochemical phase shift oscillators is outlined and the accuracy of this
      approximate technique for large dimension nonlinear chemical systems is
      considered. It is concluded that for the equations under study these techniques
      can be successfully employed to both find periodic solutions and to indicate
      those cases which can not oscillate. The technique is a general one and it is
      possible to state a step by step procedure for its application. It has a
      substantial advantage in producing results which are immediately valid for
      arbitrary dimension. As the accuracy of the method increases with dimension, it
      complements classical small dimension methods. The results obtained by harmonic
      balancing analysis are compared with those obtained by studying the local
      stability properties of the singular points of the differential equation. A
      general theorem is derived which identifies those special cases where the results
      of first order harmonic balancing are identical to those of local stability
      analysis, and a necessary condition for this equivalence is derived. As a
      concrete example, the n-dimensional Goodwin oscillator is considered where p, the
      Hill coefficient of the feedback metabolite, is equal to three and four. It is
      shown that for p = 3 or 4 and n less than or equal to 4 the approximation
      indicates that it is impossible to construct a set of physically permissible
      reaction constants such that the system possesses a periodic solution. However
      for n greater than or equal to 5 it is always possible to find a large domain in
      the reaction constant space giving stable oscillations. A means of constructing
      such a parameter set is given. The results obtained here are compared with
      previously derived results for p = 1 and p = 2.

PMID- 1022833
TI  - Competition between phenotypes.
AB  - We present two models for phenotypic-dependent interspecific competition. In both
      cases the survivorship of individuals of one population depends on the entire
      phenotypic distribution of the other species. The first model considers a
      continuously varying metric trait, with assortative or random mating; the second
      model examines a character controlled by two alleles at a single locus. Pursuing
      the notion that each population maximizes its mean fitness we define a vector
      optimum strategy using the concepts of cooperative and competitive optima. It is
      found that the dynamical constraints placed on the equations of motion by
      Mendelian genetics often prevent a population from evolving to a strategic
      optimum. However, for the single locus case with complete dominance, the
      competitive optimum always coincides with some dynamical equilibrium on the Hardy
      Weinberg manifold.

PMID- 1022834
TI  - A condition for the extinction of a branching process with an absorbing lower
      barrier.
AB  - A branching process with an absorbing lower barrier is considered. This is a
      Galton-Watson process with the condition that at any generation the number of
      individuals is greater than a lower barrier or it is equal to zero (i.e. all
      individuals in populations which are too small die and have no offspring). A
      necessary and sufficient condition is given for the process to become extinct
      with probability one. At the end of the paper there are three illustrating
      examples.

PMID- 1022835
TI  - Direct products of genetic algebras and Markov chains.

PMID- 1022836
TI  - Convergence to the equilibrium state in the Volterra-Lotka diffusion equations.
AB  - We introduce a diffusion term in the Volterra-Lotka model for two interacting
      species. For certain simple boundary conditions there exists a Lyapunov
      functional which allows to investigate the asymptotic behavior. Either the
      solution converges to equilibrium or sustained oscillations occur.

PMID- 1022837
TI  - A delayed-recruitment model of population dynamics, with an application to baleen
      whale populations.
AB  - This paper studies the delay equation chik + 1 = lambda chik + F(chik - beta),
      which has been employed as a model of baleen whale population dynamics. The two
      main questions discussed are (a) stability of equilibria, and (b) optimal
      exploitation policies.

PMID- 1022838
TI  - Solutions to a degenerate system of parabolic equations from marine biology.
AB  - A system of parabolic and ordinary differential equations ut = a2 uxx + F(u,v,w),
      vt = a2 vxx + G(u,v,w), wx = -k(u) w is studied which has been proposed by Radach
      and Maier-Reimer for the dynamics of phytoplankton and nutrient in dependence of
      light intensity. It is shown that there is a unique solution to this system
      satisfying given initial and boundary conditions. The solution depends
      continuously on the data. For specific nonlinearities F, G, and k bounds for the
      solutions are given.

PMID- 1022839
TI  - Air and water pollution.

PMID- 1022840
TI  - Toxic chemicals in food.

PMID- 1022841
TI  - A novel method for revealing unintended handwriting impressions on underlying
      layers of paper.

PMID- 1022842
TI  - The aerial use of an infrared camera in a police search for the body of a missing
      person in New Zealand.

PMID- 1022843
TI  - Bone marrow changes in the post mortem interval.

PMID- 1022844
TI  - The particle size analysis of soils and its use in forensic science--the
      determination of particle size distributions within the silt and sand fractions.

PMID- 1022845
TI  - Fatal fat embolism following severe donkey bites.

PMID- 1022846
TI  - The assessment of information content gained from the microscopical comparison of
      hair samples.

PMID- 1022848
TI  - The effects of temperature and humidity on the permanency of latent fingerprints.

PMID- 1022847
TI  - The fractionation of ABH blood group substances in saliva.

PMID- 1022849
TI  - Element profiles of automotive paint chips by X-ray fluorescence spectrometry.

PMID- 1022850
TI  - [Partial "de novo" trisomy 10q (author's transl)].
AB  - A partial 10q trisomy due to a de novo t(10;22) translocation is reported. The
      comparison with other published cases of partial 10q trisomy leads to the
      description of a particular syndrome essentially due to a trisomy for bands 10q24
      to 10q26.

PMID- 1022851
TI  - Familial macroglossia-omphalocele syndrome.
AB  - A kindred is reported in which 8 infants were affected with the macroglossia
      omphalocele syndrome. Their characteristics varied from an almost complete
      clinical picture to nodular hyperplasia with cytomegaly of the adrenals as the
      only manifestation of the disease. Chromosome analysis was normal. This syndrome
      appears to be inherited as an autosomal recessive trait, with a high proportion
      of incomplete clinical forms. The index patient also has signs of the Rubinstein
      Taybi syndrome. The simultaneous occurrence of these two syndromes is probably a
      fortuitous event.

PMID- 1022852
TI  - [Genetic counselling. I. Definition and present status (author's transl)].
AB  - Genetic counselling is a medical action which must be carried out by a M.D.
      specialized in genetics. Genetic counselling is peculiar in that couples rather
      than individuals are involved. Furthermore it is not concerned with the health of
      the consultants but with that of their expected children. Genetic counselling is
      not restricted to the statistical estimation of a risk; it raises important
      problems of psychology and behaviour. Finally, eugenic considerations about the
      diffusion of deleterious genes should not be taken into account in genetic
      counselling, which is given in the interest of individuals, not of the society.
      The increasing demand for genetic counselling is due to the change of the
      reproductive pattern. People do not want only to fix the size of their family,
      but also to avoid any accident of procreation.

PMID- 1022853
TI  - [A clinical and cytogenetic investigation carried out in a special institution
      for mentally retarded patients: preliminary results concerning 82 cases of
      oligophrenia (author's transl)].
AB  - A clinical and cytogenetic investigation carried out in a special institution for
      mentally retarded patients revealed 82 cases of oligophrenia, amongst whom were
      found 56 normal karyotypes (68.3%). Out of 25 karyotypes with chromosome
      anomalies or variants there were 18 cases of trisomy 21 and 7 others: one case of
      mosaicism with balanced translocation, 46,XX/46,XX,6p+,17q-; one case of partial
      trisomy, 46,XX,11q+; one case of pericentric inversion, 46,XY,inv(1) (p13,q21);
      one case with 8% chromosome breaks; three cases of marker chromosomes, of which
      one was of karyotype 46,XX,1qh+, and two (oligophrenic sisters) 46,XX,21p+.
      Moreover, there was an interesting case of testicular feminisation in a 9-year
      old girl with karyotype 46,XY. The authors' results corroborate those obtained in
      several important previous studies based on much larger numbers of patients.
      Amongst the 56 cases where the karyotype was shown to be normal, there were 15
      for whom a probably exogenic cause of the oligophrenia could be established,
      occurring mainly during the perinatal period. The authors were also able to
      confirm that the genetic factor plays an important role in the incidence of
      mental retardation, since in 22 examined patients, i.e. 26.8% of all cases, the
      condition was of familial type. Some interesting observations of idiopathic
      oligophrenia are reported, as well as several cases with well-known syndromes
      (Crouzon's and Cornelia de Lange's syndromes, hypothyroidism). Two cases of
      incest between father and daughter, which had produced children with serious
      oligophrenia associated, in one case, with deaf-mutism, microphthalmia,
      microcephaly and sclerocornea, are also discussed. The data show that mental
      retardation can frequently have a genetic cause, either of mendelian, chromosomal
      or multifactorial origin.

PMID- 1022854
TI  - Effects of tetraacetyl-bis-dehydroascorbic acid, a derivative of ascorbic acid,
      on Ehrlich cells and HeLa cells (human carcinoma cells).
AB  - Derivatives of ascorbic acid were synthesized, and the studies were made on their
      effects in Ehrlich ascites carcinoma cells, in regard to the inhibition and the
      prolongation of survival time as well as on the morphological degeneration in
      HeLa cells. In a model infection study carried out by using tetraacetyl-bis
      dehydroascorbic acid in dd mice infected with Ehrlich cells, it was proved that
      the prolongation of survival time was nearly double in comparison to the control
      group mice. Also, it was noted that hypertrophy due to abdominal dropsy and body
      weight were reduced much more than in the control group. From these results, the
      inhibiting effect of tetraacetyl-bis-dehydroascorbic acid was confirmed. While in
      the case of DHA and other derivatives, almost no inhibition and prolongation of
      survival time were observed. As for HeLa cells in a tissue culture, tetraacetyl
      bis-DHA, in a dosage of 125-250 mug/ml, demonstrated definitely its morphological
      degeration. After 125 mug/ml of tetraacetyl-bis-DHA was added to a tissue culture
      solution of HeLa cells, the cells were washed and recultured. No growth of the
      cells was observed. Consequently, this substance was confirmed to be anti-HeLa
      substance with a low toxicity.

PMID- 1022855
TI  - Proteins of chick duodenal brush borders during developmental changes.
AB  - Duodenal brush border membrane proteins were studied in chicks at different
      developmental stages. The protein pattern obtained from polyacrylamide gels with
      2-day-old chick preparations was distinctly different from that obtained with 20
      day embryos. The most remarkable changes were seen in the region of a protein
      with an Rf of 0.25, an area with high sucrase and maltase maltase activity, and
      in the region of a protein with an Rf of 0.28, which was characterized by
      alkaline phosphatase activity. These proteins reacted strongly with carbohydrate
      stain after hatching.

PMID- 1022856
TI  - Nitrogen source primarily supplied by amino acids and the efficacy for maximal
      growth of rats.
AB  - The effect of osmotic pressure of diets on be food intake of young rats was
      investigated by comparing the nutritional effect of casein with the corresponding
      amino acid mixture at 3.2% nitrogen level. Changes in the osmolarity of diets due
      to the type of dietary carbohydrate had a little effect on food intake, whereas
      partial substitution of casein for amino acids resulted in significant increase
      in food intake. Weight gain and food intake of rats fed the 25% replaced amino
      acid diet were compared with those of rats fed the casein diet. Food intake was
      lower at 12.5% replacement than at 25% replacement. These observation suggest
      that a well-balanced amino acid mixture supported maximal growth of rats when 25%
      of the amino acid mixture was replace with casein. This suggestion could be
      experimentally confirmed by using an amino acid mixture based on the amino acid
      composition of whole-egg protein.

PMID- 1022857
TI  - The clergy as a mental health resource: Part I.

PMID- 1022858
TI  - The clergy as a mental health resource: Part II.

PMID- 1022859
TI  - Privileged communications: when psychiatrists envy the clergy.

PMID- 1022860
TI  - The pastoral counselor in a community mental health center.

PMID- 1022862
TI  - State licensing and pastoral identity.

PMID- 1022861
TI  - Licensing--clerical or secular.

PMID- 1022863
TI  - By what authority?

PMID- 1022864
TI  - Bringing together psychology and theology: reflections on ministry to the
      bereaved.

PMID- 1022865
TI  - A mathematical model of a phantom developed for use in calculations of radiation
      dose to the body and major internal organs of a Japanese adult.

PMID- 1022866
TI  - Reactivity of nucleosides toward hydroxyl radicals in aqueous solution.

PMID- 1022867
TI  - Whole-body retention of 60CoCl2 and 58Co-cyanocobalamin in young and adult rats.

PMID- 1022868
TI  - Radiation effects on cancer mortality among A-bomb survivors, 1950-72: comparison
      of some statistical models and analysis based on the additive logit model.

PMID- 1022869
TI  - Immunoglobulin G complex interactions with rheumatoid factor and neutrophils:
      51CrCl3 labelling and 14CO2 hexose monophosphate shunt studies.
AB  - The interactions of soluble and insoluble IgG complexes with macromolecular
      rheumatoid factor (RF) and neutrophils have been examined in an in vitro system
      allowing the separate assay of the biologic activities of these elements in the
      rheumatoid inflammatory process. Studies utilizing soluble and insoluble 51CrCl3
      labelled human IgG complexes have demonstrated uptake of only the insoluble
      complexes by human neutrophils. A burst of hexose monophosphate shunt activity,
      as evidenced by increased oxidation of glucose-l-14C to 14CO2, has been shown to
      occur only when neutrophils are exposed to these insoluble complexes. High titer
      RF sera added to the insoluble complexes prior to their incubation with
      neutrophils did not affect either the uptake of the complexes or the magnitude of
      hexose monophosphate shunt activity. Native IgG and soluble IgG complexes were
      not taken up by the neutrophils and did not stimulate hexose monophosphate shunt
      activity in the presence or absence of rheumatoid sera. The addition of high
      titer RF sera to soluble IgG complexes produced precipitation of RF-IgG complexes
      which were capable of stimulating hexose monophosphate shunt activity in normal
      neutrophils. RF thus has been shown to change functionally inactive soluble
      complexes into functionally active insoluble complexes capable of stimulating
      normal neutrophils. Neutrophil stimulation by insoluble complexes may be
      important in the continuing inflammatory process occurring in the joints of
      patients with rheumatoid arthritis.

PMID- 1022870
TI  - Penicillamine in rheumatoid arthritis. Connective tissue changes and alterations
      in serum copper and phase reactants in relation to clinical improvement.
AB  - Thirteen patients, aged 27 to 70 years, with definite or classical rheumatoid
      arthritis were treated with penicillamine for six months. Skin biopsies and blood
      samples were compared with a clinical evaluation before and after therapy. The
      analyses of the skin included determinations of total collagen, thermal reaction
      of collagen, salt soluble collagen, in vitro uptake of 14C-proline and synthesis
      of 14C-hydroxyproline, as well as determinations of nucleic acids and
      proteoglycans. Serum concentrations of acute phase reactants, immunoglobulins,
      complement C3 and C4, rheumatoid factor, and iron, copper, and zinc were also
      determined. A positive correlation was found between clinical improvement and a
      fall in the number of granulocytes, a decrease in the concentration of acute
      phase reactants and serum copper, and an increase in salt soluble collagen of the
      skin. The total skin collagen decreased during treatment with penicillamine. The
      changes in skin collagen may reflect a generalized effect of penicillamine on
      collagen. These alterations may be part of an anti-inflammatory action of
      penicillamine.

PMID- 1022871
TI  - Antibodies to UV light denatured DNA in systemic lupus erythematosus: detection
      by filter radioimmunoassay and clinical correlations.
AB  - Antibodies to ultraviolet light denatured DNA (UV DNA) have been measured in
      patients with systemic lupus erythematosus (SLE) and normal subjects, using a
      millipore filter radioimmunoassay. High levels of UV DNA binding were only found
      in patients with SLE. The presence of UV DNA antibodies correlated well with the
      presence of native DNA antibodies, although immunodiffusion studies and
      inhibition techniques showed these antibodies to be immunologically distinct in
      many cases. Forty-one per cent of the SLE patients had had photosensitivity at
      some stage of their disease, but there was a poor correlation between this
      symptom and the presence of UV DNA antibodies. Although UV DNA is known to be a
      potent immunogen, none of the results from this study suggests that antibodies to
      UV DNA are more than another example of the broad spectrum of antinuclear
      antibodies seen in SLE.

PMID- 1022872
TI  - The effect of hydrocortisone acetate on adult human articular cartilage.
AB  - Living adult human articular cartilage has been maintained in tissue culture for
      eight days. Cartilage explants were cultured in one of three concentrations of
      hydrocortisone acetate or as control explants without this drug. The
      concentrations of hydrocortisone used were 0.01 microng/ml, 0.1 microng/ml and
      1.0 mg/ml. The amount of proteoglycan shed into the medium was measured and no
      significant difference was found between the explants exposed to hydrocortisone
      and those that were not. These results suggest that hydrocortisone does not have
      a catabolic effect on the proteoglycan of articular cartilage. The widely held
      view that intra-articular corticosteroid injection causes cartilage damage, must
      remain in doubt.

PMID- 1022873
TI  - Pneumococcal arthritis.
AB  - Twelve patients with pneumococcal arthritis are described. Seven of the 12
      patients had underlying diseases which predisposed them to pneumococcal
      infections; five were alcoholics and two had hypogammaglobulinemia. Five patients
      had pre-existing joint disease prior to the onset of septic arthritis. Seven
      patients had co-existent pneumococcal infection, including meningitis and/or
      endocarditis in five. The other five patients had pneumococcal arthritis without
      evidence of other foci of pneumococcal infection. With penicillin therapy and
      drainage of the purulent joint fluid (by needle aspiration in four and surgical
      drainage in seven), the function of the involved joint returned to normal or to
      the previous baseline level in all but one patient.

PMID- 1022874
TI  - "Ankylosing spondylitis" without sacroiliitis in a woman without the HLA B27
      antigen.
AB  - An elderly woman with otherwise typical ankylosing spondylitis for 45 years
      lacked radiologic evidence of sacroiliitis and the HLA B27 antigen. The illness
      was complicated by renal tuberculosis requiring a left nephrectomy 23 years after
      the onset of low back pain, and 20 years after an episode of severe iritis. After
      the eradication of the tuberculosis by surgery and chemotherapy, she has
      continued to have symptomatic spondylitis. The case seems to be an exception to
      the rule that sacroiliitis is a sine qua non for ankylosing spondylitis. Women
      with ankylosing spondylitis tend to have milder disease with an apparently lower
      frequency of roentgenographic changes in sacroiliac joints.

PMID- 1022875
TI  - HLA antigens in Europeans and Maoris.

PMID- 1022876
TI  - Abrupt onset of Sjogren's syndrome.

PMID- 1022877
TI  - Microsurgery in daily plastic surgery.

PMID- 1022878
TI  - Evoked response in the posterior cricoarytenoid to stimulation of the ipsilateral
      vagus.

PMID- 1022879
TI  - Biologic responses to low level lead exposure.

PMID- 1022880
TI  - Is the "drug holiday" harmful?

PMID- 1022881
TI  - [First and second derivatives of central pulse curves in bloodless methods of
      study of the force and rate of myocardial contractions].
AB  - An original technique was developed for the analysis of volume sphygmograms of
      the central pulse and of their derivatives that permit an indirect judgement of
      the maximum speed of aortic pressure growth and maximum acceleration. The
      technique of the examination, the methods of calculations, their substantiation
      and normal limits are presented. Examples are given of the employment of the
      technique in cases of functional and pharmacological tests. The method may be
      widely used under clinical conditions for the study of the functional state of
      the myocardium and of the individual effect of drugs (cardiac glycosides, alpha
      and beta-adrenergic receptors blockers, etc.).

PMID- 1022882
TI  - [Determination of the pre-clinical stage of circulatory insufficiency in mitral
      valve defect].
AB  - The determination of the value of the threshold physical exercise and of the
      central haemodynamic indices by means of radiocardiography permitted to prove the
      existence of a preclinical stage of circulatory insufficiency in patients with
      mitral valve disease. As early as at this stage the cardiac output is reduced at
      rest and the period of pulmonary circulation and filling of the left heart is
      increased. Under physical exercises the level of the threshold tolerance is
      decreased. Under such conditions the pre-clinical and Stage I of circulatory
      insufficiency can be easier differentiated by the direction of the haemodynamic
      changes.

PMID- 1022883
TI  - [Prognostic value of dynamic ECG changes at the late period after mitral
      commissurotomy].

PMID- 1022884
TI  - [Carotid artery pulse (analysis of the sphygmograph)].
AB  - On the basis of an analysis of carotid sphygmograms recorded in 79 patients with
      different parameters of blood flow through the aortic valve, and on the basis of
      6 experiments it was found that the pulse of the carotid arteries has a segmental
      structure. Each segment reflects a certain phase of blood ejection into the
      aorta. An analysis of 5 constant and of 1 additional (anacrotic) segments is
      given. The changes in the second segment and the appearance of the anacrotic
      segment determine the peculiarities of the sphygmograms that are typical for
      aortic stenosis.

PMID- 1022885
TI  - [Hemodynamics in patients with arteriosclerotic cardiosclerosis].

PMID- 1022886
TI  - [Comparative evaluation of the methods of treatment of embolism of the main
      arteries of the arm].
AB  - The paper presents an analysis of the results of treatment of 260 acute embolic
      occlusions in the arteries of the upper extremities of 256 patients observed in
      S.I. Spasokukotsky Clinic of Facultative Surgery. In 92.58% of the cases the
      embolic episode was caused by cardiac pathology. The optimum method of treatment
      consisted in embolectomy with the aid of the Fogarty catheter from the ulnar
      fossa that permitted to achieve full restoration of the circulation in 91.59% of
      the cases. The mortality was approximately the same in all groups of patients.
      The total mortality comprised 21.1%. The most frequently observed causes of
      mortality were embolism of the cerebral and mesenteric arteries, as well acute
      cardiac insufficiency.

PMID- 1022887
TI  - [Angina pectoris of the Prinzmetal type].

PMID- 1022888
TI  - [Volume-regulating cardio-renal reflexes].

PMID- 1022889
TI  - [Indications for reconstructive vascular surgery in gangrenous changes in the
      leg].
AB  - Proceeding from an experience in the treatment of 195 patients with obliterative
      athrosclerosis of the bifurcation of the abdominal aorta and the arteries of the
      lower extremities in the pre-gangrene or gangrene stage (reconstructive
      procedures on the vessels were performed in 151 patients), the authors conclude
      that such interventions should be considered procedures of choice. Amputation of
      the extremity may be considered in such patients only after an angiographic
      examination that is the main method that permits to determine the possibilities
      of performing a reconstructive vascular operation. Good immediate results of
      vascular interventions were achieved in 80% of the patients with stage III--IV
      ischaemia.

PMID- 1022890
TI  - [Possibilities of early functional diagnosis of arteriosclerosis obliterans of
      the main arteries of the leg].
AB  - The dynamics of blood flow volume was studied in the leg (by way of venous
      occlusive pletysmography), as well as the systolic pressure in the leg (by way of
      Winsor's volumetric determination), and the oscillometric index in the leg (by
      way of arterial oscillography with a sensitive optic recording system), these
      studies being conducted in 103 patients during reactive and work hyperenia
      corresponding in terms of the severity of the involvement of the major arteries
      to the initial, clinincally latent, stage of obliterative atherosclerosis. At the
      beginning of hyperemia diagnostically valuable and statistically significant
      shifts of the above parameters of blood supply to the leg were revealed in the
      patients, as compared to the normal individuals. Of diagnostic importance was not
      only the absolute degree of the changes in the beginning of hyperemia, but also
      the period of restoration of tthe initial level of the parameter in question.
      Some of the obtained quantitative criteria demonstrating the patency disorders in
      the major arteries of the extremities are recommended for early detection of
      persons with clinically latent obliterative atherosclerosis.

PMID- 1022891
TI  - [Diagnosis of nonspecific aortitis of thoraco-abdominal localization].
AB  - The examination was conducted in 88 patients with aortitis in one or several
      segments of the thoracoabdominal aorta. Modern instrumental, radio-isotopic and
      radio-contrast methods of examination of the vascular system were employed. A
      method of making the diagnosis based on a routine physical and instrumental
      examination was developed.

PMID- 1022892
TI  - [Indications and contraindications for surgical treatment of abdominal-aortic
      aneurysm].
AB  - An analysis of 176 patients with aneurysms of the abdominal aorta is presented,
      125 of these patients having been operated on (the average age was 60 years). The
      presence of an aneurysm of the abdominal aorta, irrespective of its dimentions
      and nature of clinical manifestations, serves as an indication for surgery,
      provided the following contraindications are absent: severe state of the patient,
      fresh myocardial infarction, cardiac lesions with circulatory insufficiency of
      stage II B or III, fresh haemorrhage to the brain, hepatic and renal lesions with
      azotemia, atherosclerotic occlusion of vessels in the lower extremities with a
      complete block of all major vessels.

PMID- 1022893
TI  - [Syndrome of chronic obstruction of the abdominal aorta and its surgical
      treatment].
AB  - The surgical management of 53 patients with high chronic occlusion of the
      abdominal aorta is reported. The authors unite this pathology under the term
      "chronic abdominal aorta obstruction syndrome". In 10 patients eversion
      endarterectomy was performed, in 22--aortofemoral bypass, in 21--prosthetic
      replacement of the aorta and of the iliac arteries with synthetic grafts. An
      original techinque of "milking" the thrombus down from the proximal aorta is
      described; it simplifies the operative procedure and prevents grave complications
      during surgery in patients with high occlusions of the abdominal aorta. Good
      results in the immediate postoperative period were achieved in 85% of the cases.
      Postoperative mortality comprised 12%. Late results were followed-up in 35
      patients during 1 to 5 years. In 28 patients the results of surgery proved good.

PMID- 1022894
TI  - [Repeated plastic operations on the abdominal aorta and main arteries of the
      pelvis and lower limbs in arteriosclerotic occlusion].
AB  - Among 600 patients operated on primarily for atherosclerotic lesions of the aorto
      iliac-femoral zone (various plastic operations) secondary interventions were
      undertaken in 140 persons with re-occlusions of the operated segments. All
      patients were subjected to secondary reconstructive-plastic operations that gave
      good results--elimination of ischaemia and preservation of the extremity--in
      77.2% of the cases. In 12.8% of them the extremity was amputated. Postoperative
      mortality comprised 10%.

PMID- 1022895
TI  - [Comparative characteristics of arteriosclerosis of the aorta and arteries of the
      limbs (epidemiological study)].
AB  - In accordance with the WHO programme, the peculiarities of age dynamics of
      atherosclerosis of the aorta and of the peripheral arteries of the extremities
      were studied in male residents of Riga, aged 50-64 years. By way of the visual
      planimetric method an assessment was made of 310 sets of aorta, common iliac,
      external iliac, femoral, innominate, subclavian, axillary and brachial arteries
      stained with Sudan IV. The age dynamics of atherosclerosis in all the studied
      arteries was represented by growing lesions with a simultaneous slight reduction
      of the lipoidosis area. The progress of atherosclerosis was irregular with the
      deceleration of the augmentation tempo in the beginning of the 7th decade of
      life. The atherosclerotic lesions of the arteries of the upper extremities were
      characterized by a considerable area of changes represented by flat fibrous
      plaques, and therefore by rare severe stenoses and absence of occlusions. The
      highest incidence and area of complicated lesions is found in the aorta. In the
      arteries of the lower extremities the area of atherocalcinosis was greater, and
      the incidence of stenoses and occlusions was high. Medium degree correlation was
      established between the indices of atherosclerosis prevalence in the aorta and
      the arteries of the extremities. The area of aortic lesions, however does not
      permit to judge the incidence of stenotic and occlusive lesions of the arteries
      of the extremities.

PMID- 1022896
TI  - [Arterial diseases and their surgical treatment].
AB  - The paper is based on the analysis of 926 operations for atherosclerotic lesions
      of the abdominal aorta and arteries of the lower extremities, of 125 operations
      for abdominal aortic aneurysms, of 77 operations for chronic disorders in
      visceral circulation, of 405 operations for renovascular hypertension, of over
      300 interventions for pathology of the aortic arch branches, of over 100
      operations for non-specific aortitis, and of 506 operations for coarctation of
      the aorta. Emphasis is made on the diagnosis of these lesions in the course of a
      clinical examination of the patients. The successs of treatment largely depends
      on early referral of the patients to specialized surgical instituions for
      operative management, as well as on correct primary diagnosis of the vascular
      lesion by general practitioners.

PMID- 1022897
TI  - [Fibrous dysplasia of renal arteries (terminology, classification, clinical
      aspects and diagnosis)].
AB  - The examination was conducted in 72 patients with renovascular hypertension
      caused by fibromuscle dysplasia of the renal arteries. According to the authors,
      fibromuscle dysplasia of the renal arteries stands third after atherosclerosis
      and non-specific aorto-arteritis. Among the preliminary diagnostic measures of
      importance are such as intravenous urography, isotope renography, scintigraphy,
      but their value is much lower than in cases of atherosclerotic stenosis or
      stenosis due to non-specific aorto-arteritis, which is attributed to a good
      collateral circulation in the kidney. The diagnosis is made on the basis of
      serial angiography data. Of importance is also the method of selective renal
      angiography with functional tests with acetylcholoine and adrenalin. To
      characterize the form of renal artery pathology, three types of stenosis are
      distinguished: monofocal, multifocal, tubular. The terminology and classification
      are discussed, and a new term is suggested: "fibrous dysplasia of renal
      arteries".

PMID- 1022898
TI  - [Aneurysm of the membraneous portion of the ventricular septum].
AB  - The presented analysis is based on the observations of 13 cases of rare
      congenital pathology--aneurysms of the membranous portion of the ventricular
      septum, as well as on the pertinent literature. The majority of the patients were
      subjected to intracardiac methods of examination; in 5 cases autopsy data are
      available. The anatomy of such aneurysms is described, the possible causes of its
      development are discussed, the haemodynamics is studied, as well as the heart
      diseases the aneurysm was accompanying. Special emphasis is given to the
      diagnosis of this pathology by way of angiocardiography, preference being given
      to left cineventriculography. The surgical implication of this pathology are
      reflected.

PMID- 1022899
TI  - [Distribution of creatine phosphokinase isoenzymes (EC 2.7.3.2) in cardiac
      cells].
AB  - The distribution of the creatinephosphokinase isoenzymes in the cardiac cells was
      studied by way of fractional extraction combined with an electrophoretic analysis
      of each of the received fractions. At the same time, the content of the
      creatinephosphokinase isoenzymes was studied in carefully purified preparations
      of myofibrils and mitochondria. The results of the conducted analysis indicate a
      heterogenic distribution of the creatinephosphokinase isoenzymes within the
      cells: about 30% of the cellular activity of the enzyme is contained in the
      mitochondria (the mitochondrial isoenzyme) 50% is comprised by the fraction
      dissolved in the cytoplasm (isoenzymes MM, MB and BB), and about 20%--in the
      myofibrils (isoenzyme MM), 5% of them being extracted only by a 0.9 M KCl
      solution. The myofibril preparation freed of the mitochondria also contains some
      important creatinephosphokinase activity (isoenzyme MM) comparable with their ATP
      ase activity. The mitochondrial isoenzymes is found only in these structures of
      the cell.

PMID- 1022900
TI  - [Oxidative phosphorylation in the mitochondria of various parts of the myocardium
      in patients with combined mitral valve defects].
AB  - The oxidative phosphorylation in the mitochondria of the left auriculum and the
      papillary muscles of the left ventricle was studied in 73 patients with combined
      mitral valve defects subjected to mitral valve prosthetic replacement. The
      examination was conducted polarographically by Chance's technique, the oxidation
      substrate being 10 mm alpha-ketoglutarate. The rate of oxidation in various
      metabolic states and the rate of phosphorylation were demonstrated to decrease
      along with the increasing course of the disease, the activeness of the rheumatic
      process, and the predominance of stenosis. In cases of distinct calcification of
      mitral valve the respiration rate increases in the 4th state, while the
      respiratory control--decreases. Nitrous oxide anaesthesia, in contrast to ether,
      results in a decreasing efficacy and rate of phosphorylation. The possible
      mechanisms of these changes are discussed.

PMID- 1022901
TI  - [Certain nitrogen-containing components of the heart, of the coronary-sinus blood
      and of the aorta in experimental myocardial infarct].
AB  - Forty-two dogs were subjected to studies of nitrogen-containing metabolites in
      the blood of the aorta, coronary sinus and in various parts of the heart under
      normal conditions and 1, 24 hours and 3 days following the induction of
      myocardial infarction. In normal dogs the myocardium usually retains from the in
      flowing blood such components as urea, glutamine, RNA, non-organic phosphates,
      while the arterio-venous gradient of ammonium, DNA and nucleases is close to
      zero. The ligation of the coronary sinus is followed by a deceleration of urea
      formation in the liver, the amount of urea formation in the liver, the amount of
      urea in the arterial blood and myocardium decreases, the latter, instead of
      retaining it, throwing it out into the coronary sinus. Like in normal cases, in
      this pathology the heart muscle is capable of synthesizing urea from ammonium.
      The infarctized heart actively retains glutamine from blood using it in situ, and
      does not increase the secretion of free ammonium into the coronary sinus. The
      level of nucleic acids and the activity of the nucleases significantly increase
      in the diseased tissue, undergoing no important changes in the blood circulating
      in the cardiac vessels.

PMID- 1022902
TI  - [Growth hormone and carbohydrate metabolism in myocardial infarct].
AB  - The indices of somatotropin were determined in myocardial infarction patients by
      means of immunological techniques, and those of blood sugar by the Hagedorn-
      Jensen technique. Single growth hormone determinations were conducted in 40
      myocardial infarction patients, aged 45 to 80 years, with different periods from
      the onset of the disease. In 23 patients the somatotropin and blood sugar indices
      were studied dynamically on the 1st--3rd and 7th--10th days of the infarction. An
      equal number of patients was subjected on the 28th--30th day of the disease to
      determinations of growth hormones secretion in conjunction with the glucose
      tolerance test (on an empty stomach, and 1 and 3 hours following the
      administration of 100 g of glucose). The conducted investigation demonstrates
      that single determinations of somatotropin fail to give grounds for conclusions
      as to its secretion due to the wide individual variations of this parameter. The
      dynamics of somatotropin content depends on the severity of the myocardial
      infarction in the given patient and does not correlate with the changes in the
      blood sugar level. Five types of somatotropin secretion were distinguished with
      the glucose-tolerance test. Patients with decreased tolerance of the
      carbohydrates tend to have a torpid and perverted types of somatotropin
      secretion.

PMID- 1022903
TI  - [Viscosity of blood, plasma and serum, in the vessels of the lesser and greater
      circulation in rheumatic mitral heart defect].
AB  - The study was conducted in 44 patients with rheumatic mitral and combined mitral
      valve disease in its inactive phase with circulatory insufficiency of Stage II,
      III or IV, according to the classification by A. N. Bakulev and E. A. Damir, and
      in 30 normal individuals. The viscosity of blood and serum flowing in different
      organs and tissues was found to undergo no changes and to be not dependent on the
      severity of circulatory insufficiency. It was concluded that the viscosity of
      blood in a peripheral vein may be used for judging its ability to flow in various
      points of the vascular bed. The viscosity of plasma was found to alter when
      passing through the brain, muscle tissue, splanchnic organs and the lungs.

PMID- 1022904
TI  - [Experience with supraduodenal choledochoduodenostomy].

PMID- 1022905
TI  - [Electrolyte balance in patients with surgical pathology of the extrahepatic
      biliary ducts].

PMID- 1022906
TI  - [Suppurative inflammatory complications in primary and recurrent cancer of the
      rectum].

PMID- 1022907
TI  - [Changes in the levels of biologically active protein-bound plasma cortisol and
      corticosterone during operations on the abdominal organs].

PMID- 1022908
TI  - [New technic of thrombectomy of the deep crural, popliteal and femoral veins].

PMID- 1022909
TI  - [Use of immunological indices in diagnosis of hepato-pancreatic system diseases].

PMID- 1022910
TI  - [Effect of intraportal infusion of drugs on the content of copper and iron in the
      blood of patients with acute cholecystitis].

PMID- 1022911
TI  - [Effectiveness of some types of novocaine blocks in acute and chronic
      pancreatitis].

PMID- 1022912
TI  - [Surgical treatment of acute pancreatitis].

PMID- 1022913
TI  - [Obturation of the bronchi by mucus as a cause of postoperative respiratory
      insufficiency].

PMID- 1022914
TI  - [Functional changes of hemostasis in patients with burns at the stage of
      septicotoxemia under ftorotan anesthesia].

PMID- 1022915
TI  - [Dynamics of some indices of nitrogen metabolism following gastric resection with
      selective vagotomy for ulcer disease].

PMID- 1022916
TI  - [Comparative evaluation of Billroth I and Billroth II gastric resection for
      gastric and duodenal ulcers].

PMID- 1022917
TI  - [Incompetence of the duodenal stump following gastric resection for ulcer
      disease].

PMID- 1022918
TI  - [Use of oil rentgenocontrast agents in new methods of research].

PMID- 1022919
TI  - [Surgery and gnotobiology].

PMID- 1022920
TI  - [Case of congenital polycystic disease of the liver and kidneys].

PMID- 1022921
TI  - [Case of Crohn's disease].

PMID- 1022922
TI  - [Fulminant form of gas gangrene in a 10-year-old child].

PMID- 1022923
TI  - [Device fascilitating collection of bile, filtration, sterilization, and pumping
      of bile into the stomach of patients with external bile fistulas].

PMID- 1022924
TI  - [Relaparotomy for early postoperative intestinal obstruction].

PMID- 1022925
TI  - [Peritoneal sepsis].

PMID- 1022926
TI  - [Adhesive technic of lung closure with aid of a jet injector].

PMID- 1022927
TI  - [Surgery of femoral and inguinal hernias by means of a modified Nyhus technic].

PMID- 1022928
TI  - [Treatment of rectal polyps using elastic ligatures].

PMID- 1022929
TI  - [Incompetence of sutures in esophago-duodenal anastomosis with recovery of the
      patient].

PMID- 1022930
TI  - [Amputation for intractable prolapse of the large intestine].

PMID- 1022931
TI  - [Peutz-Jeghers' syndrome].

PMID- 1022932
TI  - [Use of law molecular weight dextran for prevention of thrombosis in surgical
      patients (review of the literature)].

PMID- 1022933
TI  - [Morphological evaluation of late results of several modifications of
      esophagoplasty].

PMID- 1022934
TI  - [Results of gastrectomies for ulcer hemorrhage in middle-aged and elderly
      patients].

PMID- 1022935
TI  - [Treatment of chemical burns of the esophagus and the stomach].

PMID- 1022936
TI  - [Organ preserving operations with exclusion of complicated unresectable duodenal
      ulcers].

PMID- 1022937
TI  - [Physiological state of cardia in pyloroduodenal stenoses due to peptic ulcer].

PMID- 1022938
TI  - [Changes in the distal stomach in cases of duodenal ulcers complicated by
      stenosis].

PMID- 1022939
TI  - [Closed injuries of the stomach].

PMID- 1022940
TI  - [Diseases caused by Meckel's diverticulum].

PMID- 1022941
TI  - [Acute renal failure in patients with gastric and duodenal ulcers].

PMID- 1022942
TI  - [Esophago-gastroduodenoscopy in acute surgical pathology and injuries of
      abdominal organs].

PMID- 1022943
TI  - [Cause of death in peritonitis].

PMID- 1022944
TI  - [Microcirculation in acute surgical diseases of abdominal organs].

PMID- 1022945
TI  - [Amino acid composition of blood in patients with pyloric stenosis].

PMID- 1022946
TI  - [Use of polymers in surgery of the esophagus].

PMID- 1022947
TI  - [Water-salt metabolism in patients with intestinal fistulas].

PMID- 1022948
TI  - [Rare forms of colonic polyposis].

PMID- 1022949
TI  - [Surgical treatment of chronic paraproctitis].

PMID- 1022950
TI  - [Treatment of acute paraproctitis].

PMID- 1022951
TI  - [Management of anal fissures].

PMID- 1022952
TI  - [Correction of water-electrolyte disorders in preparation of patients for surgery
      of the colon].

PMID- 1022953
TI  - A trial of long-acting sulphonamide R.O. 4-4393 (fanasil) in treatment of cases
      of lepromatous leprosy with repeated E.N.L.
AB  - A trial of long-acting Sulphonamide RO.4-4393 (Fanasil) in the treatment of
      Lepromatous Leprosy patients with repeated E.N.L. is reported in this paper.
      There were 9 patients treated with Fanasil in this trial for a period of 2 years.
      The results of the trial have shown that the treatment with Fanasil helps to
      prevent the occurrence of E.N.L. under treatment with D.D.S. In addition, even
      after the completion of treatment with Fanasil, these patients seem to be
      stabilised and are able to tolerate D.D.S. But, the clinical and Bacteriological
      progress under Fanasil therapy is not satisfactory.

PMID- 1022954
TI  - Study of early nerve lesions in mice infected with M. leprae.
AB  - The present study is of quantitative histology in immunologically intact mice
      inoculated with M. leprae. Total twelve sciatic nerves are studied. The fibres
      are grouped as large, medium and small sized fibres. Initially there is loss of
      small size fibres. At later stages there is involvement of all sized fibres and
      ultimately Wallerian type of degeneration sets in. The process of regeneration is
      more active than that of human leprosy of tuberculoid type. This study adds a new
      dimension in understanding the pathogenesis of leprosy.

PMID- 1022955
TI  - Values and limitations of surgery in leprosy.

PMID- 1022956
TI  - Modified Zancolli's operation in claw hand in leprosy.
AB  - The operative technique of the Modified Zancolli's operation in claw hand is
      easy. Re-education is easier in Zancolli's capsulorrhaphy than any other
      operations. Results of this operation are encouraging. It is particularly
      required when quick turnover of cases is needed and when adequate facilities for
      physiotherapy is not available. In cases operated by Zancolli's capsulorrhaphy
      active flexion of metacarpophalangeal joint is possible. Complications are few
      e.g. pulling of capsulorrhaphy and development of flexion contracture.

PMID- 1022957
TI  - Pilocarpine test in assessment of therapeutic efficacy in maculoanaesthetic
      leprosy.
AB  - Pilocarpine test has been used since long to study the functional status of sweat
      glands. This article deals with its use in the assessment of Maculoanaesthetic
      patches of leprosy before and after therapy. This being an objective method it
      eliminates the possible pitfalls in subjective testing of sensations over the
      affected areas. Therefore, it is recommended that this test should be routinely
      employed in field work as its technique is simple. The test should be repeated at
      an interval of six months.

PMID- 1022958
TI  - Workshop on promotion of leprosy work in India.

PMID- 1022959
TI  - Congestive heart failure in two patients of lepromatous leprosy.
AB  - Two cases of lepromatous leprosy are presented with heart disease, one with
      cardiomegaly and the other with ischaemic heart disease. It is very difficult to
      say whether heart disease was due to any other cause associated with leprosy or
      due to leprous affection of myocardium. As there are no references in the
      literature regarding these, two cases are presented as problem cases.

PMID- 1022960
TI  - A study of mono-neuritic lesions in a leprosy clinic.
AB  - An analysis of 11,581 leprosy patients registered at the Acworth Leprosy Hospital
      clinic showed that 494 cases (4.3%) had primary polyneuritic leprosy and 143
      (1.2%) localised cutaneous anaesthetic lesions (or non-visible anaesthetic
      lesions), accounting for 5.5% who had no evidence of obvious skin lesions.

PMID- 1022961
TI  - Absorption of 4-4'--Diaminodiphenyl Sulfone (DDS) by incorporation in silicone
      rubber.

PMID- 1022962
TI  - Physiotherapy of combined opponens replacement of thumb and little finger.

PMID- 1022963
TI  - Classification of leprosy from the clinical point of view.
AB  - While, according to some, classification of leprosy is primarily clinical, there
      should be no objection to the application of the advances made in the last decade
      in understanding the immunological and histopathological aspects of the disease,
      provided thereby the clinical classification can be made with more accuracy.
      Unlike most other diseases, the bulk of the process of attempts at diagnosis and
      classification of this disease is still in the hands of para-medical personnel in
      the field, and hence it is important that at the same time, an easily understood,
      uniformly accepted clinical classification should be recommended for field
      workers. While tuberculoid and lepromatous leprosy of the polar types can be
      diagnosed with accuracy even under field conditions, confusion generally arises
      with reference to the diagnosis or indeterminate maculoanaesthetic and borderline
      forms, and to identify some reacting lesions. Certain terminologies in vogue add
      further to the confusion. Reacting lesions are confused with active lesions. The
      importance of recognition of varieties of reacting lesions is stressed since the
      therapeutic management in such cases is entirely different. It is suggested that
      the early forms of leprosy characterised by paucity of cardinal features of the
      disease should be separated from the more established types and grouped under the
      term indeterminate leprosy. The diagnostic points to be taken into consideration
      in these lesions are discussed. The importance of investigating thoroughly before
      classifying patients who report rarely with neuritic symptoms without any
      evidence of skin lesion is stressed.

PMID- 1022965
TI  - Rehabilitation of leprosy patients in a comprehensive control programme in
      Gudiyatham Taluk of Tamil Nadu.

PMID- 1022964
TI  - Transformation from lepromatous to borderline leprosy under clofazimine therapy.
AB  - Patients of lepromatous leprosy who have evolved from the borderline type of
      disease are known to revert to the borderline state through a reactionary
      phenomenon under anti-leprosy chemotherapy with Dapsone. We present here the case
      report of a reversal from a reactional lepromatous disease to the borderline type
      under Clofazimine.

PMID- 1022966
TI  - National leprosy control programme of the Government of India (report for the
      period ending December, 1974).

PMID- 1022967
TI  - Length of continued treatment of an inactive case of leprosy.

PMID- 1022968
TI  - Leprosy in Lakshadweep Islands.

PMID- 1022969
TI  - A spiral splint for claw fingers.

PMID- 1022970
TI  - Leprosy and health education.

PMID- 1022971
TI  - Should leprosy be a ground for divorce?

PMID- 1022972
TI  - Reactive episodes in borderline lepromatous leprosy--a case report.
AB  - A thirtyseven years old Hindu male of borderline lepromatous leprosy with
      reactions in the form of silvery white scales all over the body with scarring at
      places and greasy crusted lesion on the cheek further developed pustular
      reaction, after giving dapsone for a week, is reported.

PMID- 1022973
TI  - Heel ulcers in leprosy patients.
AB  - The incidence, causes, clinical presentation and management of ulcers of heel in
      the insensitive feet of leprosy patients are described. It is pointed out that
      heel ulcers usually arise as the result of injury and infection and are eminently
      preventable. Various surgical and non-surgical measures needed for preventing
      recurrence of the ulcer are also discussed.

PMID- 1022974
TI  - Surgical decompression of the ulnar nerve in leprous neuritis.

PMID- 1022975
TI  - Some epidemiological features of leprosy in a rural area in Hooghly district.

PMID- 1022976
TI  - Epidemiological and clinical pattern of leprosy in Goa.
AB  - A review of 1,053 patients of leprosy revealed its prevalence in the hospital
      population as 2.4 per thousand. The commonly affected age group was 20-39 in both
      sexes; males predominating females in 1.8 : 1. The sequence of frequency of
      clinical types of leprosy was tuberculoid, borderline, neuritic and lepromatous.
      Mostly the patients report in the course of 2 years of awareness of the disease.
      The clinical features were classical and type specific.

PMID- 1022977
TI  - Biochemical aspects of reactional states in leprosy.
AB  - Sequential biochemical investigations conducted in cases of lepromatous leprosy
      in the reactive as well as subsided phases indicated elevated serum levels of
      mucoproteins and sialic acids and skin levels of hydroxy-proline and hexosamine
      in the reactive phase of lepromatous leprosy. Elevation of the urinary excretion
      of hydroxy-proline and certain other amino acids was also noticed during 'lepra
      reaction'. Enhancement of serum levels of Aldolase, CPK, LDH and transaminases
      was observed in the reactive phase of lepromatous leprosy. These findings taken
      as a whole suggest a generalised tissue breakdown in lepra reaction.

PMID- 1022978
TI  - Some interesting disease combinations--report on two cases.

PMID- 1022979
TI  - [Respiratory disease in foundry workers. An epidemiologic survey in three
      foundries (author's transl)].
AB  - The authors report the results of a survey performed in three cast iron
      foundries, with particular emphasis on the impairment of respiratory system in
      the involved workers. The results obtained showed a high prevalence of
      pneumoconiosis, which, as for roentgenologic and clinical features, appears to be
      different from usual silicotic pneumoconiosis. The highest prevalence of chronic
      bronchitis -- either associated or not with pneumoconiosis -- in the foundry
      workers examined is stressed, as well as the prevalence of squamous metaplasia of
      the bronchial epithelium. An important role in this aspect is supposed to be
      played not only by dusts, but even by tobacco smoke in favouring the onset of the
      above mentioned alterations is also confirmed.

PMID- 1022980
TI  - [Assessment of working capacity in a group of subjects affected with obstructive
      respiratory disease (author's transl)].
AB  - Ventilatory function was studied by the authors in 43 subjects affected with
      obstructive respiratory disease. The research was performed both at rest and
      during two exercise tests -- 60 and 100 watts, respectively. The subjects were
      divided into three groups on the basis of tidal volume (at 30 1 ventilation) /
      vital capacity ratio. It was found that during muscular effort subjects with
      major impairment of spirometric indexes hypoventilated, whereas the opposite
      occurred in patients with lesser impairment. Moreover, subjects hyperventilating
      during muscular work were found to have brandypnea, whereas the opposite occurred
      in hyperventilating patients. It is suggested that progressing and worsening of
      obstructive emphysema lead to a relative hypoventilation during muscular work,
      which is due to an "inability" to increase the frequency of breathing.

PMID- 1022981
TI  - Finding families in a six state area.

PMID- 1022982
TI  - Cutting costs and raising production with a medical secretaries incentive plan.

PMID- 1022983
TI  - A new approach to clinical experience. A faculty's perception.

PMID- 1022984
TI  - An external degree program. A continuing education opportunity.

PMID- 1022985
TI  - Proposed national health insurance legislation.

PMID- 1022986
TI  - Lexicons and linguistics.

PMID- 1022987
TI  - What is OD?

PMID- 1022988
TI  - How health statistics are misused.

PMID- 1022989
TI  - Online retrieval system at U of I tumor registry.

PMID- 1022990
TI  - Patient identification numbers and automated medical records.

PMID- 1022991
TI  - Incentive pay for medical transcriptionists.

PMID- 1022992
TI  - Medical record technician program at Boise State University.

PMID- 1022993
TI  - A contemporary medical record administration program in a university setting.

PMID- 1022995
TI  - A report on LATCH (Literature Attached to Charts).

PMID- 1022994
TI  - Work simplification. Does it work simply?

PMID- 1022996
TI  - Guidelines for initiating nursing audit.

PMID- 1022997
TI  - AMRA project emphasizes a meeting of the minds on nursing home records.

PMID- 1022998
TI  - Patient ID system used to control charges.

PMID- 1023000
TI  - The medical record practitioner as an MR educator.

PMID- 1022999
TI  - Educational and professional mobility, change, and the medical record
      practitioner.

PMID- 1023001
TI  - The medical record practitioner as an MR educator.

PMID- 1023002
TI  - New retrieval system for Harris Hospital.

PMID- 1023003
TI  - A guide to the new federal rules governing the confidentiality of alcohol and
      drug abuse patient records.

PMID- 1023004
TI  - What is H.R. 1984?

PMID- 1023005
TI  - Have we conquered the communicable diseases?

PMID- 1023006
TI  - Some characteristics and services of Chinese medical practitioners in Malaysia.

PMID- 1023007
TI  - The improvement of immunization coverage by early immunisation of children in
      Malaysia.

PMID- 1023008
TI  - Study of one hundred cases of typhoid fever in University Hospital Kuala Lumpur
      (October 1967 to July 1972).

PMID- 1023009
TI  - Vasectomy.

PMID- 1023010
TI  - Occurrence of opium alkaloids in commercial herbal stomach remedy preparation.

PMID- 1023012
TI  - Face presentation.

PMID- 1023011
TI  - Incidence of otosclerosis in the three ethnic groups in Malaysia.

PMID- 1023013
TI  - Some aspects of prevention of coronary artery disease.

PMID- 1023014
TI  - Tapeworm infection in Perlis.

PMID- 1023015
TI  - The testicular feminisation syndrome.

PMID- 1023016
TI  - Choroid plexus papilloma five years after shunting for hydrocephalus.

PMID- 1023017
TI  - The pterygium and mitomycin-C therapy.

PMID- 1023018
TI  - Carotid body tumour -- a case report.

PMID- 1023019
TI  - Case report of renal tubular acidosis presenting with periodic paralysis.

PMID- 1023020
TI  - Resistance of insect vectors of diseases to insecticides in Malaysia and other
      South East Asian countries.

PMID- 1023021
TI  - [Glass fibers: exposure and risks for man].

PMID- 1023022
TI  - Presence and identification of fibres in the atmosphere of Milan.

PMID- 1023023
TI  - [Ergonomics in the design and use of machine tools in the auto industry].

PMID- 1023024
TI  - [Evaluation of incipient pulmonary emphysema in workers exposed to inhalation of
      irritant gases].

PMID- 1023025
TI  - [Reproducibility of expiratory flow rate in various pulmonary volumes in normal
      subjects and patients with asthmatic bronchitis].

PMID- 1023026
TI  - [Urinary hydroxyproline in silicosis and silicotuberculosis].

PMID- 1023027
TI  - [Most important directions in studies of tropical parasitic diseases].

PMID- 1023028
TI  - [Activity of the Health World Organization in the field of research and training
      personnel in tropical diseases].

PMID- 1023029
TI  - [Treatment of the urinary bladder schistosomiasis with niridazole].

PMID- 1023030
TI  - [Problems of schistosomiasis in the Yemen Arab Republic].

PMID- 1023031
TI  - [Dynamics of antibody production in white mice experimentally infected with
      cutaneous leishmaniasis].

PMID- 1023032
TI  - [Sandflies (Diptera, Psychodidae, Phlebotominae) of east Afghanistan. IV: The
      genus Sergentomyia, the subgenus Parrotomyia].

PMID- 1023033
TI  - [Malaria import into the Irkutsk region].

PMID- 1023034
TI  - [Importation into the USSR of intestinal helminthiasis from tropical countries].

PMID- 1023035
TI  - [Trials of Altozid SR-10 drug with juvenile activity against mosquitoes, Culex
      pipiens pipiens L].

PMID- 1023036
TI  - [Diagnostic value of biochemical analysis of the urine (determination of volatile
      fatty acids) in ascaridosis].

PMID- 1023037
TI  - [Preservation of feces using Barbagallo fluid, for helmintho-coprological
      studies].

PMID- 1023038
TI  - [Modification of Berman's method suitable for mass screening for
      strongyloidosis].

PMID- 1023039
TI  - [Experience of taeniarhynchosis control in the Ternopol region].

PMID- 1023040
TI  - [Exerience of malaria prophylaxis in the Zaporozh'e region].

PMID- 1023041
TI  - [Case of mass attack of Boophthora erythrocephala de Geer on people in Bulgaria].

PMID- 1023042
TI  - Transient cycloheximide resistance in a tobacco cell line.
AB  - Cylcoheximide-resistant cell lines have been recovered from tissue cultures of
      haploid Nicotiana tabacum at the usual mutant frequency (10(-6)). One such line,
      CR 4/6 was studied in detail. Resistance is based on the potential of the callus
      to inactive cycloheximide. The transient nature of the resistance and its
      association with differentiated cells indicate that the new phenotype is not due
      to a mutation, but rather to an alteration in gene expression.

PMID- 1023043
TI  - Probabilities of transversions and transitions.
AB  - The values of the mean relative probabilities of transversions and transitions
      have been refined on the basis of the data collected by Jukes and found to be
      equal to 0.34 and 0.66, respectively. Evolutionary factors increase the
      probability of transversions to 0.44. The relative probabilities of individual
      substitutions have been determined, and a detailed classification of the nonsense
      mutations has been given. Such mutations are especially probable in the UGG (Trp)
      codon. The highest probability of AG, GA transitions correlates with the lowest
      mean change in the hydrophobic nature of the amino acids coded.

PMID- 1023044
TI  - Isolation of a hybrid between rat ribosomal RNA and DNA.
AB  - A procedure for the isolation and purification of a specific hybrid between rat
      28S and 18S ribosomal RNA's and nucleolar DNA is described. The method employed
      includes the following steps: 1) isolation of the nucleolar DNA, 2) hybridization
      of [14C]rRNA with the nucleolar DNA, and 3) isolation and purification of the
      rRNA-DNA hybrid complex by chromatography on hydroxylapatite and centrifugation
      in a CsCl density gradient. In the isolated hybrid complex the RNA:DNA ratio is
      close to 1:1, and the degree of enrichment of the DNA by the rRNA cistrons is
      about 1500 times. The hybrid obtained has a sedimentation constant on the order
      of 20S, is resistant to the action of pancreatic RNase and RNase T1 and sheep
      brain DNase, and is characterized by high thermostability. Acording to the
      physicochemical tests used, the rRNA-DNA hybrid complex is a double-stranded poly
      nucleotide with an ordered secondary structure.

PMID- 1023045
TI  - Influence of base sequence on the stability of the double helix of DNA.
AB  - On the basis of published measurements of the melting transitions of synthetic
      polydeoxyribonucleotides with known sequences we have determined the parameters
      of the interplane (stacking) interactions of base pairs in DNA over the range of
      ionic strengths from 0.01 to 0.1 M Na+. We found that deviations of the stacking
      interaction energy from the mean value of 7-8 kcal/mole were extremely small and
      did not exceed 0.2 kcal/mole. We report an analysis of the influence of the
      heterogeneity of the stacking interactions on the melting parameters of
      polynucleotides with random sequences (models of natural DNA's). Inclusion of
      this effect does not significantly distort the linear dependence of the melting
      temperature on the relative content of G-C pairs and insignificantly affects the
      width of the helix-coil transition in DNA under normal conditions. However it is
      the heterogeneity of the stacking interactions that plays the crucial role in the
      melting of DNA under conditions where the difference between the relative
      stabilities of the A-T and G-C pairs tends to zero, as in concentrated solutions
      of tetraethylammonium and tetramethylammonium salts.

PMID- 1023046
TI  - Electron-microscopic study of the serological affinity between the antigenic
      components of phages T4 and DDVI.
AB  - In an investigation of the antigenic fine structure of phages T4 and DDVI with
      the use of the neutralization reaction and electron-microscopic observation of
      the phage-antibody complexes, it has been possible to establish that the head of
      phage T4 consists of proteins which have antigenic determinants of two types: The
      first type is identical to the antigens of the head of phage DDVI, and the second
      type is apparently absent in phage DDVI. The phage DDVI head contains mostly
      determinants which are common to the phage T4 head, since it was not possible to
      detect antigenically specific components in the phage DDVI head. The tail sheaths
      of phage T4 and DDVI appear to be identical in the antigenic respect. A
      difference has been observed in the fibers and the base plates of the phages
      investigated. The presence of the following three types of antigens has been
      established: 1) common to phages T2, T4, and DDVI, 2) common to phages T4 and
      DDVI, and 3) specific for each phage investigated.

PMID- 1023047
TI  - Reliability of elements and systems in enzymology.
AB  - The applications of the elements of reliability to the description of the
      stability and aging processes of enzymes and polyenzyme systems have been
      considered. The inactivation of individual enzymes or polyenzyme systems whose
      activity varies on the molecular level according to the "all-or-nothing"
      principle is described by an exponential reliability law. Systems of enzymes
      which are inactivated according to an exponential law have been considered. It
      has been shown that in the case of enzymes functioning in parallel, the value of
      the mean time of continuous operation is determined by the most stable enzyme,
      while in the case of sequentially functioning enzymes, this value is determined
      by the most labile. Systems whose aging process is related to the accumulation of
      "latent errors" and whose inactivation is characterized by gradual breakdowns are
      described by a normal reliability law. Systems with a combination of exponential
      and normal reliability laws have been considered. The use of a series of rigid
      quantitative criteria, such as the mean time for continuous functioning has been
      proposed for characterizing the stability of enzymes and polyenzyme systems. The
      theoretical points have been illustrated by experimental data on the stability of
      enzymes with hydrogenase activities, isolated chloroplasts, and cells of
      microscopic blue-green algae.

PMID- 1023048
TI  - Influence of antibodies against DNA on the renaturation of DNA.
AB  - The treatment of denatured T4 phage DNA with antiserum for the DNA of this phage,
      containing antibodies against glucosylated 5-hydroxymethylcytosine, decreases the
      ability of DNA for renaturation. The greatest inhibiting activity is possessed by
      antiserum for T4 phage DNA irradiated with UV light, which contains antibodies
      not only against glucosylated 5-hydroxymethylcytosine, but also against the usual
      nitrogen bases. Antiserum against E. coli DNA, containing antibodies to the usual
      nitrogen bases, in equal dilutions with the antisera indicated above, shows less
      inhibitory activity on the renaturation of T4 phage DNA.

PMID- 1023049
TI  - DNA replication and head assembly in bacteriophage T4.
AB  - Phage DNA was accumulated in cells of E. coli B, infected with the phage T4DtsLB3
      (gene 42), without the synthesis of late proteins (in the presence of
      chloramphenicol). Then (stage II), chloramphenicol was removed and further
      replication of the phage DNA suppressed with hydroxyurea and by simultaneously
      raising the temperature to 40 degrees. The media M9 or M9 with 1% amino acid were
      used; the times of addition of chloramphenicol and the hydroxyurea concentration
      were also varied. It was also shown that in medium M9, at stage II, chiefly early
      proteins were synthesized. In the medium containing amino acids, at stage II the
      following was observed: 1) DNA synthesis was entirely suppressed and a
      degradation of DNA occurred; 2) both early and late proteins were synthesized,
      with a predominance of the latter; 3) an assembly of the elements of the phage
      tails and capsids occurred without the neck and flagellum, and a small number of
      phage particles were also found; 4) the capsids, isolated in a sucrose density
      gradient after lysis with chloroform, contained the proteins Palt, P20, P23, P24,
      several unidentified proteins, and did not contain Pwac, P23, and P22, 5) the
      yield of viable phage varied from 0.05 to 15% per cell. Thus, the entire
      morphogenesis of T4 phage can occur without accompanying replication of phage
      DNA.

PMID- 1023050
TI  - Structure of animal mitochondrial DNA: nucleotide composition, pyrimidine
      clusters, and methylation character.
AB  - The nucleotide composition, relative concentration of pyrimidine clusters, and
      the degree of methylation of the mitochondrial and nuclear DNA's of various
      vertebrates and the protozoan Crithidia oncopelti have been studied. With respect
      to the relative concentration of GC pairs, the mtDNA of animals (bull, rat) does
      not differ from the corresponding nDNA. The relative concentration of GC pairs in
      the mtDNA of certain fish and birds is 1.5-2.5 mole% higher than in the
      respective nDNA. The kinetoplast DNA of the protozoan C. oncopelti (where the
      relative concentration of the GC pairs is 42.9 mole %) differs very sharply in
      composition from the nDNA (where the relative concentration of GC pairs is 51.3
      mole %). The mtDNA's and kDNA's studied are distinguished from the respective
      nDNA'S by a lower degree of clustering of pyrimidine nucleotides. The proportion
      of mono- and dipyrimidine fragments in the mtDNA and kDNA is 30 mole %, while in
      the nDNA it does not exceed 23 mole %. The relative concentration of long
      pyrimidine clusters (hexapyrimidine clusters of larger) in the mtDNA is smaller
      than in the nDNA by a factor of 2-5. The low degree of clustering of the
      pyrimidine nucleotides is apparently characteristic of all the known mtDNA's and
      may support the fact that they have a single type of organization and are of a
      single origin. All the vertebrate mtDNA's studied contain 5-methylcytosine as a
      minor base (1.5-3.15 mole %), and their level of methylation is 1.5-2 times
      greater than that in the respective nDNA's. It has been shown that animals
      display species specificity with respect to the 5-methylcytosine content in the
      mtDNA. Its distribution among the pyrimidine clusters in the bovine heart mtDNA
      differs substantially from that in the nDNA. This suggests that the methylation
      specificities of nuclear and mitochondrial DNA are different. A DNA methylase,
      which effects the in vitro methylation of cytosine residues both in the
      homologous mtDNA and in different heterologous DNA's, has been found in rat liver
      and bovine heart mitochondria. The specificity of the in vitro methylation of the
      cytosine residues in the same heterologous Escherichia coli B DNA by the nuclear
      and mitochondrial enzymes is different: The mitochondrial enzyme methylates
      predominantly in monopyrimidine fragments, and the nuclear enzyme methylates
      mostly in di- and tripyrimidine fragments. They, therefore, recognize different
      nucleotide sequences.

PMID- 1023051
TI  - Stereochemical analysis of the secondary structure of polypeptide chains with the
      aid of Courtauld three-dimensional models. II. Hydrogen and hydrophobic bonds.
AB  - Sterically permissible hydrogen bonds between side chains and the backbone, which
      fix a small number of angles of internal rotation have been identified. The
      hydrogen bonds on the ends and within the secondary structures, as well as the
      most important bonds in the alpha helix and in irregular structures, have been
      considered.

PMID- 1023052
TI  - Study of the relationship between the subfraction composition of histone F1 and
      the type of tissue in birds.
AB  - The subfraction composition of lysine-rich histone has been studied with the aid
      of polyacrylamide gel electrophoresis. The subfraction compositions of the
      histone F1 of several tissues from the chicken, pigeon, and titmouse have been
      compared. The histone F1 from the tissues investigated consists of four or five
      subfractions of similar number and electrophoretic mobility (1, 1a, 2, 3, and 4).
      In the different avian species each subfraction varied its mobility independently
      of the others. The chicken tissues investigated can be divided into two classes,
      depending on the relative concentration of subfractions 2 and 3 (A and B): Class
      A (subfraction 2 is smaller than 3) includes the brain, liver, skeletal muscle,
      heart, muscular layer of the stomach, and pancreas, and class B (subfraction 2 is
      larger than 3) includes the intestinal mucosa, thymus, and testes, as well as the
      liver, heart, and pancreas from a 21-day embryo. Such a division of the tissues
      corresponds to the varying rate of their cellular renewal. In a parallel
      examination of the relative concentrations of the individual subfractions in the
      same tissues from the three avian species it has been found that the relative
      concentration of subfractions 3 and 2 is increased in the skeletal muscles,
      heart, brain, and liver, that subfraction 2 is increased in the intestinal
      mucosa, that subfractions 4 and 3 are increased in the pancreas, and that
      subfractions 1, 1a, and 4 are increased in the erythrocytes. The results obtained
      may be interpreted as a consequence of some relationship between the subfraction
      composition of histone F1 and the type of tissue of the source.

PMID- 1023053
TI  - Structure of nuclear pre-mRNA. VIII. Isolation and characterization of
      complementary sequences.
AB  - After the annealing of pre-mRNA at high Cot values, up to 20% of the material
      becomes resistant to the action of ribonuclease. This has been attributed to the
      presence of self-complementary sequences (scRNA) in the pre-mRNA. The most
      important properties of scRNA, which was isolated in preparative amounts, have
      been studied. The approximate dimensions of the complementary segments are 45-50
      nucleotides. Hybridization experiments have shown that scRNA is transcribed from
      repeated segments of the genome. It may be postulated that the rapidly
      hybridizing pre-mRNA fraction consists mainly of self-complementary sequences.

PMID- 1023054
TI  - Differences in AT- and GC-base pair ratios in DNA of the paracentromeric
      heterochromatin of chromosome 1 in two human cell types. I. Autoradiographic
      analysis of the incorporation of 3H-labeled thymidine and 3H-labeled
      deoxycytidine.
AB  - The distribution of AT- and GC-base pairs in DNA along chromosomes 1 and 2 has
      been studied in primary cultures of human embryo fibroblasts and peripheral blood
      leukocytes by an autoradiographic method using 3H-labeled thymidine and 3H
      labeled deoxycytidine. The two cell types differed in their relative contents of
      DNA and in the ratio of AT and GC pairs at the centromere and the adjacent region
      of heterochromatin in chromosome 1. The DNA content of this section was higher in
      fibroblasts than in leukocytes, mainly because of AT pairs. In both cell types,
      the telomere in the short arm of this chromosome had a higher content of GC pairs
      than AT pairs. No differences were observed in base pair distribution along
      chromosome 2 in the two types. This phenomenon may be due to incomplete
      replication, or to loss by some means of part of the genetic material during the
      development and differentiation of the cellular systems.

PMID- 1023055
TI  - A study of risk factors in nonembolic cerebrovascular disease.

PMID- 1023057
TI  - Epilepsy and solar activity--an hypothesis.

PMID- 1023056
TI  - Relationship of cognitive functions of epileptics with clinical variables.

PMID- 1023058
TI  - Recurrent Bell's palsy.

PMID- 1023059
TI  - Cerebral AV malformation and aneurysm with polycystic kidney.

PMID- 1023060
TI  - Transorbital gunshot wound causing contralateral trigeminal injury--an unusual
      case.

PMID- 1023061
TI  - Intramedullary cord tuberculoma resembling glioma.

PMID- 1023062
TI  - [Infected penetrating wounds of the cornea].

PMID- 1023063
TI  - [Morphohistochemical changes in the eye tissues in experimental benzine poisoning
      in albino rats].

PMID- 1023064
TI  - [Surgical treatment of glaucoma with the use of ultrasonic knife].

PMID- 1023065
TI  - [Results of sinusotrabeculectomy in primary glaucoma].

PMID- 1023066
TI  - [Effect of certain physical factors on the regulation of intraocular pressure in
      pathological climacteric].

PMID- 1023067
TI  - [Reconstructive surgical treatment of injuries of the iris].

PMID- 1023068
TI  - [Effectiveness of flap sclerectoiridectomy].

PMID- 1023069
TI  - [Effectiveness of treatment of primary glaucoma with prolonged-action
      pilocarpine].

PMID- 1023070
TI  - [Hypotensive effect of oculocompression and the state of the vitreous body].

PMID- 1023071
TI  - [Therapeutic value of ultrasonics in certain eye diseases].

PMID- 1023072
TI  - [Ultrasonic therapy of progressive myopia].

PMID- 1023073
TI  - [Fluctuation of dark adaptation].

PMID- 1023074
TI  - [Study of "nasal reserve" of visual field in early diagnosis of glaucoma].

PMID- 1023075
TI  - [Experimental basis for the use of hydrocortisone in uveitis].

PMID- 1023076
TI  - [Remote results of treatment of strabismus in children].

PMID- 1023077
TI  - [Clinical aspects and diagnosis of optic-chiasm leptomeningitis].

PMID- 1023078
TI  - [DNA synthesis in the antimesometrial and mesometrial regions of rat decidual
      tissue].
AB  - DNA synthesis in the decidual tissue of rats on the 9-10th day of pregnancy has
      been studied in intact rats and under the effect of chloridin by means of
      radioautography and biochemical methods. The decidual cells of antimesometral and
      mesometral regions were shown to differ both by morphological features and
      intensity of 3H-thymidine utilization and activity of thymidylate synthetase and
      thymidine kinase. Under the conditions of the block of dihydropholate reductase,
      differences between the antimesometral and mesometral regions of deciduoma
      manifest themselves still more markedly. The decidual tissue consists of a
      heterogenous population of cells which differ by the ratio of different ways of
      thymidylate synthesis. An estimate is given for the ratio of two ways of
      thymidine monophosphate synthesis in the antimesometral regions of the decidual
      tissue.

PMID- 1023079
TI  - [Electrophoretic study of water-soluble retinal proteins of chickens at early
      stages of embryogenesis].
AB  - The water-soluble proteins of chick retina were studied during the formation of
      eye cup and at the early stages of histological differentiation of retina by the
      micro-method of electrophoresis in 20% polyacrilamide gel. The retina of embryos
      at the stages under study contains a range of proteins forming over 20 fractions
      in electrophoresis. The most fractions are formed by the proteins which
      electrophoretic mobilities exceed that of serum albumin. The early stages of
      retina development are characterized by the definite changes in its protein
      composition. These changes manifest themselves in the disappearance of the most
      anodic fractions beginning from the stage of contact between the optic vesicle
      and presumptive lens ectoderm. During the subsequent development, these proteins
      are detected again in the retina, the corresponding anodic fractions being most
      distinct at the stage of completed eye cup. Their content in the retina decreases
      repeatedly with the beginning of histogenesis up to their complete disappearance.

PMID- 1023080
TI  - [Heat stability of cholinesterase and non-specific esterases during development
      of hybrids of the sea urchins Stongylocentrotus droebachiensis and S.
      intermedius].
AB  - Acetylcholine esterase (AchE) and non-specific esterases were studied during the
      development of sea urchins Strongylocentrotus droebachiensis and S. intermedius
      and their hybrids by means of electrophoresis and measurements of enzyme
      thermostability. Two AchE fractions were found which differed by thermostability.
      At the late gastrula stage, the therolabile form predominated and at the mid
      pluteus stage the thermostable one. Non-specific esterases in both the species of
      sea urchins are represented by complex isozyme systems. Their changes during
      development are accompanied by the changes in thermostability and electrophoretic
      patterns. The thermostability of esterases at the pluteus stage in the hybrids is
      higher than in the maternal species, apparently, due to the appearance of the
      thermostable enzyme which appears in the paternal species provisionally at the
      prism stage.

PMID- 1023081
TI  - [Development of hypothalamic control over thyrotropin secretion during human
      prenatal life].
AB  - It was shown in the tissue culture experiments that the human hypophysis secreted
      autonomously the thyrotrophin during the last three fourths of the prenatal life.
      The intensity of secretion is the highest in the end of the first third of this
      period, then it decreases, but during the last third it increases reliably again.
      During the second half of development the level of thyrotrophin in female
      foetuses in reliably higher than in the male ones. In the beginning of the second
      third of prenatal life, the hypothalamic factors decrease the autonomous
      thyrotrophin secretion twice in foetuses of both the sexes. In the end of the
      second third, sexual differences appear in their effect; they decrease reliably
      the autonomous thyrotrophin secretion in the male foetuses, whereas no such
      effect is observed in the female ones. The stimulating effect of the hypothalamic
      thyrotrophin releasing hormone manifests itself during the last third of prenatal
      life in foetuses of both the sexes. During the second half of prenatal life, the
      thyrotrophin concentration in blood of female foetuses is also reliably higher
      than in male foetuses. There is a positive correlation in female foetuses between
      the thyrotrophin concentration in blood and the level of hypophysial secretion
      under the effect of hypothalamic factors. Thyrotrophin is found in the cranial
      fluid of foetuses. In some cases its concentration in the cranial fluid is higher
      than in the blood. No correlation was found between the levels of the hormone in
      fluid and blood in female foetuses; a positive correlation was found in male
      foteuses.

PMID- 1023082
TI  - [Thyroid hormones in the early postnatal development of the CNS: effect of
      hyperthyroidism on proliferative activity of white matter cells of rat
      cerebellum].
AB  - The effect of triiodothyronin on the proliferative activity of the white matter
      cells has been studied by means of radioautography in the cerebellum vermis and
      hemisphere of developing rats. The index of labelled nuclei and the mitotic index
      of the white matter glial elements in both the cerebellum regions of 7 and 10
      days old hyperthyroid animals are markedly reduced. Besides, the general tendency
      was found towards the increase of the mitotic cycle duration in the white matter
      cells due to the lengthening of S and G2 + 1/2 M periods. The data obtained are
      discussed with respect to the importance of thyroid hormones for the CNS
      development.

PMID- 1023083
TI  - [Compensatory hypertrophy of golden hamster ovaries during early postnatal
      ontogenesis].
AB  - The right-side ovariectomy in the golden hamster females during the prepubertate
      period resulted in the compensatory hypertrophy of the rest paired organ. The
      morphological rearrangement of the hypertrophied ovary represented the shift in
      the quantitative distribution of follicles by the maturation stages towards the
      predominance of mature forms. The accelerated growth and differentiation along
      the path of normal postnatal ontogenesis led to the earlier ovulations in the
      hypertrophied ovary.

PMID- 1023084
TI  - [Role of Bruch's membrane in the process of metaplasia of the ocular pigmented
      epithelium of Xenopus laevis].
AB  - The metaplasia of pigmented epithelium into retina with the formation of nuclear
      and reticular layers took place in the experiments with wrapping a sheet of
      pigmented epithelium from tadpoles up in the Bruch's membrane of adult frogs X.
      laevis. The implant with de novo formed retina resembled the inverted eye. In
      those experiments where the Bruch's membrane of tadpoles came into contact with
      that of adults only depigmentation of the pigmented epithelium cells was
      observed. The pigmented epithelium metaplasia suggests that the Bruch's membrane
      is permeable not only for low molecular weight substances, but also for inducing
      agents. The adult Bruch's membrane serves in the process of metaplasia in the
      experiments described as a new and limiting system which ensures more orderly
      formation of new retina.

PMID- 1023085
TI  - [Viability at different stages of development and early embryogenesis of
      Drosophila virilis and D. littoralis and their hybrids].
AB  - The low percentage of larval hatching both in the initial lines and the hybrids
      of direct and back crosses was shown to be due to the low fertilizability of
      eggs. A study of early embryogenesis, up to the gastrulation, has shown that the
      F1 hybrids (female D. virilis x male D. littoralis) develop at a lesser rate than
      both the parental species. Some embryos of these latter attain the stage of
      blastoderm syncytium for 2 hrs whereas the hybrid embryos attain only the stage
      of polynuclear syncytium.

PMID- 1023086
TI  - [Proliferative potentials of Xenopus laevis tadpole and toad optic thalamus nerve
      tissue cells following injury].
AB  - After the injury of the thalamus right hemisphere in tadpoles and young frogs X.
      laevis, 3H-thymidine incorporated in the cells of the thalamus ventricular zone,
      but not in the middle and large neurons of the type of neurons of the trigeminal
      nerve mesencephalic nucleus and the large ganglion cells of VI and VIII layers of
      the thalamus cortex. The brain trauma in tadpoles resulted in the activation of
      cell proliferation in the ventricular zone, whereas in young frogs the
      proliferation of glyocytes was activated. The relation of the proliferative
      reaction of certain types of brain cells to the trauma to the loss of ability for
      brain regeneration is discussed.

PMID- 1023087
TI  - [Pituitary somatotropic function of newborn infants].
AB  - The content of the hypophysial somatotrophic hormone was studied in the blood of
      cord vessels at parturition and in the peripheral blood of newborn infants during
      the first 2 hrs and 1-9 days of life. The hormone level by the periods of 2 hrs
      was markedly lower than in the foetuses, it sharply increased by the end of the
      first day and gradually decreased during the subsequent days. The functioning of
      the hypothalamic-hypophysial system in humans during this period is discussed.

PMID- 1023088
TI  - [Concentration and comparison of adenylic nucleotides in the eye tissues of
      rabbits during ontogenesis].
AB  - The ATP content in the rabbit eye tissues increases from birth till the time of
      sight appearance (12-15th day after birth). The ADP and AMP content did not
      increase during the period of sight appearance. After this period, the ATP
      content decreased down to the level of newborn tissues. The ADP and AMP content
      increased in the eye tissues of 2 months old and adult rabbits.

PMID- 1023089
TI  - Wilson's disease (hepatolenticular degeneration).
AB  - Wilson's disease, or hepatolenticular degeneration, is a rare inherited disorder
      of copper metabolism which usually affects young people. Excess copper
      accumulates in the tissues, primarily in the liver, brain, and cornea. This
      copper deposition results in a wide range of hepatic and neurological symptoms,
      and may produce psychiatric illness. Hepatic involvement often occurs in
      childhood, while neurological deficits generally are detected at a later age. The
      disease is inherited in an autosomal recessive fashion. Ocular findings are of
      particular importance because the corneal copper deposition, forming the Kayser
      Fleischer ring,is the only pathognomonic sign of the disease. The structure of
      the ring and the presence of copper have been well established. An anterior
      capsular deposition of copper in the lens results in a characteristic sunflower
      cataract in some of these patients. Other ocular abnormalities have been
      described but are much less common. The pathogenesis of the disease and the basic
      genetic defect remain obscure. It is clear that there is excess copper in the
      tissues, but the mechanism of its deposition is unknown. It is in some way
      associated with a failure to synthesize the serum copper protein ceruloplasmin
      normally. Another theory suggests that an abnormal protein with a high affinity
      for copper may bind the metal in the tissues. The diagnosis may be suggested by
      the clinical manifestations and confirmed by the presence of a Kayser-Fleischer
      ring. In the absence of these findings biochemical determinations are necessary.
      The most important of these are the serum ceruloplasmin, the urinary copper, and
      the hepatic copper concentration on biopsy. Treatment consists in the
      administration of the copper chelating agent, penicillamine, and the avoidance of
      a high copper intake. This usually results in marked clinical improvement if
      irreversible tissue damage has not occurred. Maintenance therapy for life is
      necessary in order to continue the negative copper balance. The detection and
      prophylactic treatment of asymptomatic individuals with the disease is especially
      important. Seven cases of Wilson's disease have been presented in order to
      illustrate many of the features which have been discussed, with emphasis on the
      ocular findings.

PMID- 1023090
TI  - Diagnosis of lacrimal drainage malfunction (with emphasis on the technetium 99m
      scan).

PMID- 1023091
TI  - A gel electrophoretic study of the protein and nucleic acid components of African
      horsesickness virus.
AB  - The physico-chemical structure of African horsesickness virus (AHSV) is compared
      with that of some of the other members of the Reoviridae, and in particular with
      that of bluetongue virus (BTV), the type strain of the orbivirus genus. This
      study adduces evidence of a great similarity between the gel electrophoretic
      patterns of the polypeptides of AHSV and BTV. The molecular mass values of the 7
      AHSV polypeptides range between 0,30 x 10(5) and 1,46 x 10(5) dalton, a variation
      similar to that of BTV. The close relation between AHSV and BTV is further
      affirmed by the gel electrophoretic resolution of the AHSV double-stranded RNA
      genome into 10 segments.

PMID- 1023092
TI  - Experimental intraspinal trypanosoma equiperdum infection in a horse.
AB  - To establish the ability of Trypanosoma equiperdum to cross the blood-brain
      barrier in the horse, a susceptible stallion was infected via the cerebrospinal
      fluid of the subarachnoid space by lumbosacral puncture. Cerebrospinal fluid with
      low detectable levels of trypanosomes removed from a dourine-infected mare by
      lumbosacral puncture was used for infecting the animal. The parasite was detected
      in blood smears of the recipient 13 days after infection and the subsequent
      parasitaemia and clinical course of the disease followed that of naturally
      infected horses.

PMID- 1023093
TI  - [Extrafocal osteosynthesis in the treatment of pseudarthrosis and defects of the
      long tubular bones].

PMID- 1023094
TI  - [Errors and complications following endoprosthesis of the head of the femur with
      a Moore-CITO endoprosthesis in middle and old age].

PMID- 1023095
TI  - [Treatment of ununited fractures and pseudarthroses of the neck of the femur in
      persons of middle and old age].

PMID- 1023096
TI  - [Experimental basis for an artificial knee joint].

PMID- 1023097
TI  - [X-ray picture of regenerate formation following distraction epiphyseolysis].

PMID- 1023098
TI  - [Microflora of a purulent wound and its sensitivity to antibiotics, antiseptics
      and bacteriophages].

PMID- 1023099
TI  - [Endoprosthesis of the hip joint after Sivash in congenital and pathologic
      dislocation of the hip].

PMID- 1023100
TI  - [Choice of approach for surgical treatment of tumors in the region of the lesser
      trochanter and posterior-inferior surface of the neck of the femur].

PMID- 1023101
TI  - [Repair of defects using nylon mesh in subcutaneous tears of the Achilles
      tendon].

PMID- 1023102
TI  - [Physical therapy for postoperative and post-traumatic joint contracture].

PMID- 1023103
TI  - [Sanatorium-health resort stage in the rehabilitation of patients following hip
      surgery].

PMID- 1023104
TI  - [Treatment of ganglia of the radio-carpal joint with hydrocortisone injections].

PMID- 1023105
TI  - [Strength of tendons restored with preserved allografts].

PMID- 1023106
TI  - [Variants of muscle repair for postoperative bone defects of the pelvis].

PMID- 1023107
TI  - [Compression arthrodesis of the ankle joint and adjacent foot joints].

PMID- 1023108
TI  - [Use of cruciform plates for arthrodesis of the hip joint].

PMID- 1023109
TI  - [Solafur electrophoresis in the treatment of patients with post-traumatic
      suppurative processes of the soft tissues].

PMID- 1023110
TI  - [Rehabilitation of World War II invalids with amputation stumps of the limbs].

PMID- 1023111
TI  - [Use of coding in orthopedics and traumatology].

PMID- 1023112
TI  - [Approach to examination of patients with severe multiple and complex injuries].

PMID- 1023113
TI  - [Osteosynthesis in fresh fractures of the long tubular bones].

PMID- 1023114
TI  - [Disability and mortality for traffic accidents].

PMID- 1023115
TI  - [Errors in the diagnosis of injuries and their sequelae in syringomyelia
      patients].

PMID- 1023116
TI  - [X-ray dynamics of bone regenerate development during experimental lengthening of
      the femur].

PMID- 1023117
TI  - [Effectiveness of decompression surgery in coxarthrosis].

PMID- 1023118
TI  - [Syndrome of painful scapular crepitation].

PMID- 1023119
TI  - [Isolated dislocation of the head of the ulna].

PMID- 1023120
TI  - [Relationship between the duration and outcome of therapy and the quality of
      transport immobilization in diaphyseal fractures].

PMID- 1023121
TI  - [Dynamics of several biochemical and clinico-microscopic indices of biological
      fluids in closed and open crural injuries].

PMID- 1023122
TI  - [Dynamics of x-ray changes following osteosynthesis of fractures with an angular
      bone beam].

PMID- 1023123
TI  - [Surgical treatment of osteochondromas in the region of the popliteal fossa].

PMID- 1023124
TI  - [Intra-articular pressure in habitual dislocation of the shoulder].

PMID- 1023125
TI  - [Use of the perfocards with border perforations in the study of spinal
      pathology].

PMID- 1023126
TI  - [Functional method of treating dislocations of the acromial end of the clavicle
      by using a pin with support].

PMID- 1023127
TI  - [Prevention of pin dislodging and tissue infection during fracture treatment by
      skeletal traction].

PMID- 1023128
TI  - [Fracture treatment with a figure-8 with wire suture].

PMID- 1023129
TI  - [Old shoulder dislocations and features of their surgical treatment].

PMID- 1023130
TI  - [Portable atomizer for medicinal solutions].

PMID- 1023131
TI  - [Intramedullary osteosynthesis of the tibia with Kuntscher's nail for the hip].

PMID- 1023132
TI  - Acid-labile amino acid precursors in the Murchison meteorite. 1: Chromatographic
      fractionation.
AB  - The amino acid content of a hot water extract of the Murchison meteorite can be
      increased by over 100 per cent by subjecting the extract to acid hydrolysis. The
      acid-labile compounds in the extract that account for this increase were
      fractionated by column chromatography on a cation exchange resin. Seventy mole
      per cent behaved as neutral or acidic compounds and were eluted from the column
      with an initial water wash. The remaining 30 mole per cent (basic precursors)
      were retained on the column and were eluted with the free amino acids by aqueous
      NH4OH. The acid-labile amino acid precursors in the water eluate could be
      retained and further fractionated on an anion exchange column, indicating that
      they are acidic compounds.

PMID- 1023133
TI  - Acid-labile amino acid precursors in the Murchison meteorite. II: A search for
      peptides and amino acyl amides.
AB  - The basic fraction of the acid-labile amino acid precursors found in hot water
      extracts of the Murchison meteorite was treated with ninhydrin under conditions
      that give destruction of free amino acids but allow nearly complete recovery to
      peptides and amino acylamides. After this treatment and a subsequent acid
      hydrolysis, the amount of amino acids found corresponded to less than 30 per cent
      of the precursor content of the basic fraction. Since only 30 percent of the
      total extract precursors are found in the basic fraction, these results indicate
      that such compounds, if present, account for no more than 9 mole per cent of the
      total acid-labile amino acid precursors of the meteorite hot water extract.

PMID- 1023134
TI  - Chemical evolution: effect of high energy radiation.
AB  - Quantitative estimation - based on extrapolated data of radioactivity and
      reasonable assumptions about the radiolytic effect of beta-particles on amino
      acids- shows that an assymmetry greater than the statistical fluctuation in the
      number of L-, and D-amino acid molecules could have been produced by beta-decay
      during chemical evolution.

PMID- 1023135
TI  - Volcanic processes and synthesis of simple organic compounds on primitive earth.

PMID- 1023136
TI  - Clays as possible catalysts for peptide formation in the prebiotic era.
AB  - From the point of view of prebiotic synthesis, clays might have performed
      functions of concentration, catalysis, and protection of molecules. The degree of
      polymerization obtained when amino acid adenylates are added to montmorillonite
      suspensions in water, are much iigher than those obtained by polymerization in
      the absence of such a clay. In addition, they are of a discrete spectrum, usually
      multiplies of 6 or 7, and reach values of up to 40 mers. In the absence of clay a
      continuous spectrum of degrees of polymerization is obtained, and usually up to 4
      6 mers only. Copolymerization in the absence of clays yields mostly random
      copolymers in their presence mostly block copolymers are obtained. Optical
      density measurements show that after adsorption has taken place on the clay,
      stacking of its layers occurs. Polymerization starts only after these stacked
      layers have been formed. The distance between the layers - as measured by X-rays 
      increase during polymerization, probably because the resulting polymers settle
      in their interspace, while the adsorption site of the active monomers is at the
      edges of the clay.

PMID- 1023137
TI  - Polarized bremsstrahlung not the source of optical activity.
AB  - An evaluation is made of the previously proposed scheme (polarized beta-particles
      leads to circularly polarized bremsstrahlung leads to optically active molecules)
      by which dissymmetry at the elementary particle level may be transmitted to the
      molecular level. The calculations suggest that much too small a fraction of the
      total energy of the electron appears as light, capable of causing photochemical
      resolution, to explain results obtained in the laboratory on the preferential
      radiation-induced decomposition one enantiomer of chiral amino acids.

PMID- 1023138
TI  - A speculation on the origin of protein synthesis.
AB  - It is suggested that protein sythesis may have begun without even a primitive
      ribosome if the primitive tRNA could take up two configuration and could bind to
      the messenger RNA with five base-pairs instead of the present three. This idea
      would impose base sequence restriction on the early messages and on the early
      genetic code such that the first four amino acids coded were glycine, serine,
      aspartic acid and aspargine. A possible mechanism is suggested for the
      polymerization of the early message.

PMID- 1023139
TI  - Prebiotic phosphorylation of nucleosides in formamide.
AB  - A possible prebiotic phosphorylation method has been investigated in which
      formamide served as the reaction medium. Nucleotides and nucleotide derivatives
      were formed when nucleosides were allowed to react with different orthophosphate,
      hydrogen phosphate or dihydrogen phosphate salts or with different condensed
      phosphate salts. The reaction products obtained from the phosphorylation of
      adenosine were 2'3' and 5'-AMPs, 2',5' and 3',5'-ADPs and 2',3'-cyclic AMP. The
      extent of phosphorylation in formamide exceeded 50% under favorable conditions
      after 15 days at 70 degrees. The acidic dihydrogen phosphates and condensed
      hydrogen phosphates proved to be the best phosphorylating agents. The presence of
      water in the medium decreased the yield of nucleotide derivatives, but some
      phosphorylation of adenosine was detected using dihydrogen phosphate in formamide
      containing water. The phosphorylation reactions were also observed for
      deoxynucleosides. Little decompression of the nucleosides was detected during the
      reaction time needed to form nucleotide derivatives. The facility with which
      phosphorylation takes place in formamide under very mild conditions may justify
      further studies both of prebiotic phosphorylation and synthetic phosphorylation
      using this solvent.

PMID- 1023140
TI  - Scavenging of soluble organic matter from the prebiotic oceans.
AB  - The existence of hot or cold "nutrient broth" or "primeval soup" is challenged on
      the basis of the recent geochemistry of soluble organic carbon in the oceans.
      Most of the dissolved organic carbon is recycled quickly by organisms, but the
      residual, biologically refractive, organic matter is efficiently scavenged from
      the oceans (residence time of 1000 to 3500 years) by nonbiologically mediated
      chemical and physical processes, such as adsorption on sinking minerals,
      polymerization and aggregation to humic type polymers or by aggregation to
      particulate matter through bubbling and sinking of this material to the ocean
      bottom. Since there is no reason to believe that such nonbiological scavenging
      was not operative in the prebiotic oceans as well, then the prolonged existence
      of "organic soup" is very doubtful. The question of the origin of life is thus
      assumed to be related to solid-liquid interfacial activity, and the answer may be
      associated with sediment-water interaction rather than with solution chemistry.

PMID- 1023141
TI  - [Perspectives of the control of Opisthorchis invasion by the method of treating
      the molluskan population].
AB  - Sanitation of the mollusk population with highly effective cercaricide
      preparations can be used for the control of opisthorchosous infection. Low
      concentrations of molluskocides which are sublethal for non-infected mollusks
      have turned to be lethal for hyperinfected individuals. All tested molluskocides
      display a cercaricide effect in concentrations which are considerably lower than
      molluskocide ones. Low concentrations of cercaricides are toxic both for
      cercariae and parthenites from the liver of mollusks and for freely swimming
      cercariae. Disastrously affecting the freely swimming cercariae microdoses of
      cercaricides prevent the infection of the second intermediate hosts. Microdoses
      of cercaricides which are lethal for cercariae are not toxic for the majority of
      hydrobionts including fishes of all age groups. As far as the dynamics of the
      infection level of Bithynia with O. felineus is characterized by a one-peak curve
      with a distinct peak in the middle-end of July the treatment of water bodies with
      microdoses of cercaricides should be carried out just in this period.

PMID- 1023142
TI  - [Morphology and biology of cystophorous cercariae from the Bering sea].
AB  - Three new species of cystophorous cercariae, Cercaria appendiculata Pelseneer,
      1906, C. octocauda Tschubrik, 1952 and C. saccocaudata Tschubrik, 1966, are
      described from the gastropod Tectonatica clausa (Broderip et Sowerby). C.
      saccocaudata is a larva of trematodes of the genus Lecithaster. The development
      of parthenites of this species carries out within one summer season. Parthenites
      of C. appendiculata and C. octocauda are capable to survive unfavourable winter
      conditions and produce cercariae in the next summer. The above three species were
      found to eject cercariae through the ejaculatory tube which is an important
      adaptation of chemiurids to the infection of the second intermediate hosts.

PMID- 1023143
TI  - [Feeding behavior of Trichinella as a leading factor of adaptation to the body of
      the mammals].
AB  - Studies were carried out of the permeability of the cuticle of Trichinella
      spiralis (Owen, 1835) for fluorochromes and histidine, the filling of the mid-gut
      and the amino-acids contents in it. The quantity of glicogene in different organs
      was estimated. A conclusion has been grown that a larva consumes food through the
      integuments of its body; intestinal Trichinella use within the first 20 hours of
      their development the reserves of glicogene and later consume food monomeres and
      oxygen from the host's mucous membrane through their integuments. The mode of
      feeding of Trichinella was formed during their evolution as an adaptation to
      parasitism on the mucous membrane of the host.

PMID- 1023144
TI  - [Characteristics of acquired resistance of lambs to mature ticks Hyalomma
      asiaticum asiaticum (experimental studies)].
AB  - A new method was employed for studies of parasite-host relationships between
      ixodid ticks and their hosts. It has been established that ixodid ticks are able
      to desensibilize the reactive sensibility of the host and to satiate themselves
      without unhibiting the latter. Every day and long parasitism of the ticks on
      cattle (in nature) and increasing doses of secretion of the ticks' saliva
      (sensibilizer) lead apparently to the weakening of the host's organism
      (desensitization). However, under laboratory conditions in hosts a resistence to
      bites of ixodid ticks can appear.

PMID- 1023145
TI  - [Uneven degree of aging of intestinal epithelium of hungry ticks Ixodes
      persulcatus].
AB  - Adult individuals of I. persulcatus are characterized by uneven assimilation of
      nutrients in digestive cells of the mid-gut. In the mid-gut of females and males
      exist simultaneously parts with different degrees of exhaustion. Physiological
      age of a hungry individual is determined by three items: "main" physiological
      age; degrees of exhaustion "accompanying" it; and, in addition, by different
      degrees of exhaustion of individual digestive cells in the limits of one portion
      of the mid-gut. Calculation of the area of the portions of the "main" and
      "accompanying" degrees of exhaustion has shown that the former is always maximum
      one. This suggests the availability of different food resources in hungry ticks
      of different physiological ages.

PMID- 1023146
TI  - [Role of gamasids in the epizootiology of tularemia].
AB  - 10 strains of Francisella tularensis were isolated from 4 species of gamasid
      mites, Laelaps muris, L. multispinosus, Hyperlaelaps amphibius and Haemolaelaps
      glasgowi, in natural nidi of tularemia in the Tumen district. Under experimental
      conditions L. muris is often infected with tularemia agent on sick animals but
      preserves it at an indoor temperature not more than a week and does not transmit
      it transovarially. Haemogamasus ambulans preserve the agent within the same
      period. L. muris and Hirstionyssus isabellinus do not transmit the tularemia
      agent to healthy animals through a bite.

PMID- 1023147
TI  - [Characteristics of digestion of blood of different animals by the flea
      Xenopsylla cheopis].
AB  - Under experimental conditions fleas X. cheopis engorged and assimilated blood of
      4 species of rodents, man, pigeon and two species of reptiles. Histological
      investigations have shown that the structure of food clot, destruction rate of
      blood  cells and general duration of digestion are changed considerably depending
      on the host's blood. In females the digestion of white mice blood to haematin at
      23-24 degrees lasted not over 12 hours, the digestion of blood of hamsters and
      man - 12 to 20 hours, of guinea pigs and reptiles - 18 to 25 hours and of white
      rats and pigeons - from 20 to 30 hours. In males the digestion carries out
      somewhat slower. The above differences in blood digestion can apparently create
      unequal conditions for pathogenic microbes in the intestine of fleas that affects
      the preservation and reproduction of the agent in the organisms of these
      carriers.

PMID- 1023148
TI  - [Crystals in the epithelial nuclei of the midgut of fleas].
AB  - On studying the changes in the epithelium of the midgut of Ceratophyllus
      tesquorum, C. laeviceps and Leptopsylla segnis intranuclear crystals were found
      during the process of digestion. They were recorded both from young and adult
      insects. The crystals were absent from nuclei of cells of regeneration nests,
      epithelium of the fore-intestine, any other organs or from nuclei of epithelial
      cells of the stomach of young non-feeding individuals. They were found neither in
      young nor in adult individuals of Xenopsylla conformis and Neopsylla setosa.

PMID- 1023149
TI  - [Effect of the bacterial preparation, insectin, on the fleas Xenopsylla cheopis].
AB  - The effect of 0.2-2 mg/g of insectine (Bacillus insectus) upon the Ist-IInd stage
      larvae of X. cheopis is very negligible but it manifests itself in the subsequent
      low (9 to 30%) development and hatching of imagos. The III stage larvae are more
      resistent and after the effect of 10 mg/g of the preparation 9% of larvae formed
      cocoons which later developed into imagos. Adult fleas poorly responded to 0.2-2
      mg/g of insectine. However, 10-30 mg/g of insectine caused in four days a mass
      death of fleas and their population decreased to 70% as compared to control.

PMID- 1023150
TI  - [Acid-base equilibrium and state of the circulation of patients with massive
      blood loss and trauma].

PMID- 1023151
TI  - [Effect of micropolarization in focal epilepsy].

PMID- 1023152
TI  - [Change in adrenocortical reactivity in vasorenal hypertension].

PMID- 1023153
TI  - [Effect of non-specific sensitization on the development of atherosclerosis in
      rabbits].

PMID- 1023154
TI  - [Disorders in microcirculation of blood in the mesentery of the small intestine
      of rats with experimental acute pancreatitis].

PMID- 1023155
TI  - [State of respiration and oxidative phosphorylation, activity of mitochondrial
      enzymes of the liver in the presence of toxic liver diseases].

PMID- 1023156
TI  - [Effects of changes in alpha- and beta-adrenergic sensitivity on the anaphylactic
      reaction of guinea pig bronchi].

PMID- 1023157
TI  - [Effect of sorbitol infusions on the course of acute toxic hepatitis].

PMID- 1023158
TI  - [Effect of immunotherapy on the toxic properties of an extract of burned skin
      under experimental conditions].

PMID- 1023159
TI  - [Mechanism of action of leukocyte pyrogen on granulocytopoiesis].

PMID- 1023160
TI  - [Change in erythropoiesis during experimental post-transfusion polycythemia].

PMID- 1023161
TI  - [Effect of hyperoxia on the ventilatory function of the lungs in middle and old
      age].

PMID- 1023162
TI  - [Relationship between the antipyretic effect of amidopyrine and the functional
      state of the thermoregulatory structures of the anterior hypothalamus].

PMID- 1023163
TI  - [Changes in the mitotic index of rat corneal epithelium in the presence of skin
      burns].

PMID- 1023164
TI  - [Clinical physiology and methods of studying patients in the system for preparing
      expert physicians].

PMID- 1023167
TI  - A systems approach to the multiple trauma victim.

PMID- 1023168
TI  - Problems in human sexuality encountered in primary care.

PMID- 1023170
TI  - [Evolution of oncogenic RNA viruses: facts and hypotheses].

PMID- 1023171
TI  - [Diphtheria toxin. Effects on sensitive cells, structure of the toxin molecule
      and mechanism of its action].

PMID- 1023172
TI  - [Congenitally asplenic mice: their characteristics and use in immunology].

PMID- 1023173
TI  - [Interactions between chemotherapeutics and other drugs].

PMID- 1023174
TI  - [Role of the coagulation and fibrinolytic systems in glomerulonephritis].

PMID- 1023175
TI  - [Study of heat denaturation of collagen dispersions by a method of IR
      spectroscopy].
AB  - Infrared spectroscopy was used to examine the kinetics of deuterium exchange in
      collagen films prepared from its 0.5% dispersions obtained from cattle tendons
      and healed at 25--100 degrees C for 30 min. The temperature relationships to the
      denaturation degree and time of deuterium exchange suggested that an almost
      complete heat denaturation of dispersions can be achieved at 31.5 degrees C. The
      temperature of semi-denaturation of dispersions was 28.5--29.0 degrees. The
      occurrence of intact supermolecular aggregates of collagen molecules in its
      dispersions had no effect on the system resistance to heat denaturation.

PMID- 1023176
TI  - [Osteoarticular changes in the feet in diabetes mellitus according to the data of
      roentgenological examination].
AB  - In roentgenological examination of 40 patients suffering from diabetes mellitus
      bone and articular changes were revealed in 65% of cases. They were equally
      incident in patients of both sexes. These changes did not depend directly on the
      severity and duration of diabetes mellitus, although they were more frequent in
      persons with the widespread micro- and macroangiopathies and other complications
      of this disease. A case of osteoarthropathy occurring in a young patient given no
      antidiabetic treatment for a period of several years is presented.

PMID- 1023177
TI  - [Activity of blood serum lactate dehydrogenase, malate dehydrogenase and their
      isoenzymes in hypothyroidism].

PMID- 1023178
TI  - [Erythrocytometric indicators of peripheral blood in hypothyroidism before and
      after treatment].
AB  - In studying the erythrocytometric peripheral blood indices in patients with
      hypothyroidism there was revealed an increase of the mean diameter, mean volume
      and thickness of the red blood cells. There was revealed that in the process of 4
      week replacement therapy with lyothyronine-2-hydrochloride the patients with mild
      and moderately severe affection displayed an increase of the mean diameter of
      erythrocytes, a reduction of their thickness and volume and a fall of microcyte
      count. As to the patients with severe hypothyroidism--they show no significant
      dynamics of the erythrocytometric indices after one month of treatment.

PMID- 1023179
TI  - [Gastrointestinal tract in diseases of the adrenal cortex].
AB  - Clinico-roentgenological study of the gastrointestinal tract was carried out in
      86 patients with diseases of the adrenal cortex. A hyperplastic relief of the
      gastric mucosa was revealed in the adreno-genital syndrome, Itsenko-Cushing's
      disease, androsteroma and glucosteroma; the relief was hypoplastic in Addison's
      disease. Ulcerative lesions found in Addison's disease were erosive and
      associated with the corticosteroid therapy instituted. Functional changes in
      small intestine in Itsenko--Cushing's disease, glucosteroma and Addison's disease
      were chiefly hypomotor-hypotonic in character, and in the adreno-genital syndrome
      and androsteromas--hypermotor-normotonic. Electrogastrography revealed different
      disturbances in the rhythm and amplitude of oscillations in the gastric
      biopotentials pointing to the changes in the vegetative innervation.

PMID- 1023180
TI  - [State of the muscular blood circulation in diabetes mellitus].
AB  - With the aid of Xe133 injected into the anterior tibial muscle a study was made
      of the state of muscular circulation in 50 patients with decompensated diabetes
      mellitus and in 23 patients after the compensation of the disease was reached.
      There was a marked reduction of the muscular circulation in the majority of the
      patients at rest and also a fall of the adaptive possibilities of the vessels in
      response to the physical loading under conditions of artificially induced
      ischemia. Compensation of diabetes against the background of complex therapy
      (vasodilating, antisclerotic, lipotropic agents, polyvitamins, potassium salts)
      promoted but an insignificant improvement of the circulation at rest. The extent
      of disturbances of the muscular circulation depended on the severity, the
      character of the course of the disease, the patient's age, and the presence of
      vascular affections. Adaptive possiblities of the vessels in diabetic patients
      became more pronounced with the development of hypertension. The character of
      diabetes treatment produced no significant influence on the extent of the
      circulatory disturbances in the muscles.

PMID- 1023181
TI  - [LH, FSH and progesterone level in the blood plasma of women with normal
      menstrual cycle].
AB  - Luteinizing hormone (LH), folliculostimulating hormone (FSH) and progesterone
      were studied by the radioimmunoassay in a group of 10 women throughout a normal
      menstrual cycle. The LH and the FSH peak occurs at the middle of the cycle. At
      the early follicular phase the FSH level was higher than that of the LH. During
      the follicular and the lutein phases the plasma progesterone level was 0.65 +/-
      0.12 ng/ml and 12.4 +/- 2.3 ng/ml, respectively. The laboratory criteria of the
      normal ovular cycle are: a) a mid-cycle LH peak; b) plasma progesterone level at
      the lutein phase were 10-15 times greater than at the follicular one; c)
      progesterone peak at the mid-lutein phase; d) the duration of the lutein phase of
      12-15 days.

PMID- 1023182
TI  - [Case of spontaneous remission of eosinophilic granuloma of the frontal bone
      complicated by hypothalamo-hypophyseal changes].

PMID- 1023183
TI  - [Organization of specialized service to patients with endocrine pathology].

PMID- 1023184
TI  - [Change in the insulin and lipid content of blood of rats with hypothalamic
      obesity].

PMID- 1023185
TI  - [Change in calorimetric indicators of energy metabolism and thermoregulation
      reaction in obese albino rats].
AB  - A study was made of the changes in the calorimetric indices of the energy
      metabolism (heat emission, "direct" thermoproduction and body temperature) in
      albino rats with adiposity due to overfeeding and ovariectomy. From the age of 4
      months an additional feeding of highly caloric food to normal and ovariectomized
      animals led to a marked and significant gain in weight. There were marked
      quantitative changes in the calorimetric indices and the reaction of
      thermoregulation expressed both in a significant reduction of the initial values
      of thermal emission, heat production and body temperature, and in the chnages of
      the reactive peculiarities of heat exchange: reduction of heat emission,
      diminished accretion of heat production and of the rate of restoration of body
      temperature after functional "cold" test--in comparison with such in normal
      animals.

PMID- 1023186
TI  - [Determination of Stokes' radii of the cytoplasmic receptor molecules for
      estradiol in various organs of rats].
AB  - A method of gel-filtration of Sepharose 6B was used; Stoke's radii (a) of some
      forms of cytoplasmic receptors of estrogens of the uterus, kidneys, and the liver
      of male and female rats were determined. In the initial cytozol in elution with
      buffer of low ionic strength estrogenic uterine receptors were presented chiefly
      by the form with a congruent to 70A, and the receptors of the male and female
      kidneys--by the form with a congruent to 30 A; receptors of the liver of males
      and females were represented by both forms, in females the content of the form
      with a congruent to 70 A somewhat exceeded the content of the form with a
      congruent to 30 A. At the same time in the males the form with a congruent to 30
      A prevailed. In elution with a buffer of a high ionic strength the receptors of
      all the organs under study eluated with a congruent to 20--26 A. Formation of a
      form with a congruent 20--26 A in case of receptors of the liver of males and the
      uterus was reversible under the action of a high salt concentration. Receptors of
      all the organs under study were capable of forming Ca2+-stabilized form with a
      congruent to 35 A in elution with a buffer of low ionic power and a congruent to
      21-26 A in elution with a buffer of high ionic strength.

PMID- 1023187
TI  - [Immunoreactive insulin in the blood of pregnant women with different disorders
      of glucose tolerance].
AB  - The authors studied the content of immunoreactive insulin (IRI) during the
      glucose tolerance test (GTT) in 57 pregnant women at various periods of pregnancy
      and in 10 nonpregnant women at the same age. There proved to be a significant
      increase in IRI in the blood on fasting stomach and during the GTT in all the
      pregnant women examined. In the pregnant women with doubtful GTT results and
      latent diabetes the IRI content was significantly greater than in healthy
      nonpregnant women and in the diabetic women. There was a tendency to the increase
      of IRI content in the blood of pregnant women with an excessive weight in
      comparison with the pregnant women with a normal weight.

PMID- 1023188
TI  - [Effect of epiphysectomy on the circadian rhythm of the glucocorticoid, androgen,
      estrogen and gestagen functions of the endocrine organs].
AB  - Investigations were carried out on intact, pseudoectomized and epiphysectomized
      Wistar rats (male and female) with the following illumination regimen: light--10
      hours, darkness--14 hours. By the method of competitive protein binding and by
      fluorimetry a determination was made of the blood content of corticosterone,
      estrogens, androgens and gestagens. The peripheral blood content of the hormones
      under study in the intact animals corresponded to literature data. In comparison
      with the intact animals epiphysectomy changed the circadian rhythm of the blood
      corticosterone (11-OCS) level. In comparison with the pseudoepiphysectomized
      animals, in the epiphysectomized animals the progesterone content fell
      significantly at 6 a.m., at noon, and at 6 p.m. In comparison with the intact
      group, under the effect of epiphysectomy estrogen and androgen content increased
      at almost all the observation hours.

PMID- 1023189
TI  - [Humoral factors in the regulation of the natriuretic function of the kidneys].
AB  - Acute experiments were conducted on dogs. Intravenous injection of adrenalin (1-
      2 Mg/kg/min) caused an increase in the blood renin content and a reduction of the
      renal excretion of sodium, potassium and water. Noradrenaline (1--2 Mg/kg/min)
      produced the contrary changes in the renin secretion and diuresis, this being
      associated with a different activity of catecholamines in respect to tha alpha-
      and beta-adrenoreceptors. It is supposed that in acute hemodynamic shifts renin
      could play the role of intrarenal mediator of the natriuretic reaction.

PMID- 1023190
TI  - [Enzymatic status of the leukemia cells of children during treatment].

PMID- 1023191
TI  - [Methylation of newly synthesized extra-replicative DNA in the lymphocytes of
      healthy subjects and patients with chronic lympholeukosis].

PMID- 1023192
TI  - [Changes in nucleic acid structure and their metal binding in leukoses].

PMID- 1023193
TI  - [Concentration and activity of nucleic acids in the peripheral blood leukocytes
      of patients with leukemia and anemia].

PMID- 1023194
TI  - [Changes in the concentration of 2,3-diphosphoglycerate and adenosine
      triphosphate in the erythrocytes of leukemia patients].

PMID- 1023195
TI  - [Maturation of cells of the megakaryocyte series in the bone marrow of patients
      with a portal hypertension syndrome subjected to surgical treatment].

PMID- 1023196
TI  - [Cytochemical study of hydrolytic enzymes in the hematopoietic cells of healthy
      persons].

PMID- 1023197
TI  - [Changes in the blood clotting system of persons suffering chronic alcoholism].

PMID- 1023198
TI  - [Effect of chlororganic pesticides on the development of blood diseases].

PMID- 1023199
TI  - [Myeloma disease developing into acute plasma cell leukemia].

PMID- 1023200
TI  - [Lymph node morphology in chronic subleukemic lympholeukemia with a favorable
      course].

PMID- 1023201
TI  - [Case of splenic cyst diagnosed during life].

PMID- 1023202
TI  - [Changes in the leukogram of healthy persons during adaptation to conditions in
      the north].

PMID- 1023203
TI  - [Method of determining the quantity of total exchangeable iron in man by the
      method of whole body radiometry using Fe59].

PMID- 1023204
TI  - The natural history of prostatic cancer.
AB  - There are inner and outer gland groups in the human prostate. Benign nodular
      hyperplasia develops from the inner group of glands. Cancer develops from the
      outer gland group and consequently spreads beyond the prostate at an early stage
      in the disease. The biological malignancy of prostatic cancer varies from patient
      to patient and from part to part of the same tumor. Some tumors remain
      biologically inactive or latent so that there must be some naturally-occurring
      factor which controls tumor growth in these cases. Prostatic cancer patients may
      be divided into groups which differ in their response to endocrine treatment.
      These differences in response may be due to changes in the host or in the tumor
      cells. The temporary state of tumor retardation or latency follows endocrine
      treatment - generally anti-androgenic - in about 70 - 80% of all cases of
      prostatic cancer, but whatever form of treatment is used, about 75% of all cases
      die within 3 years. Even in tumors which show a marked response, endocrine
      treatment does not destroy all tumor cells. Hormone sensitivity therefore is not
      a property of the tumor as a whole but may vary from part to part of the same
      tumor. We need adequate well controlled clinical trials before we can decide
      which method of teatment is best but before we can do this satisfactorily we need
      methods to allow us to assess the stage and biological activity of individual
      tumors, before treatment begins.

PMID- 1023205
TI  - Pathology and classification of prostatic carcinoma.

PMID- 1023206
TI  - Measurement of androgen receptors in human prostatic tissue: methodological
      considerations.

PMID- 1023207
TI  - Radical perineal prostatectomy for prostatic cancer.

PMID- 1023208
TI  - The use of cryosurgery in the management of carcinoma of the prostate.

PMID- 1023209
TI  - Retropubic implantation of I125 in the treatment of prostatic cancer.

PMID- 1023210
TI  - Radiation therapy for carcinoma of the prostate.

PMID- 1023211
TI  - Radiotherapy of prostatic cancer.
AB  - The methods of treatment and the general guidelines in the treatment of prostatic
      cancer are discussed. Emphasis is placed upon treatment planning with the help of
      ultrasonography and the use of high energy photons.

PMID- 1023212
TI  - Radiotherapy in prostatic carcinoma preliminary report of lymph node involvement
      and its prognostic significance.

PMID- 1023213
TI  - Intraurethral irradiation of prostatic cancer using afterloading technique.

PMID- 1023214
TI  - Treatment of advanced carcinoma of the prostate with Estracyt.

PMID- 1023215
TI  - Evaluation of prostatic cytology in primary diagnosis and clinical course of
      prostatic carcinoma.
AB  - Franzen's method of transrectal aspiration biopsy, capable of being performed
      without narcosis or hospitalization of the patient, is an ideal method of early
      recognition of prostatic carcinoma, and its reliability is equal to the more
      elaborate transrectal or transperineal needle biopsy. For the appraisal of the
      local therapy-effect, transrectal aspiration biopsy can be successfully used if
      no high-voltage radiation treatment of the primary tumour has been administered.
      For local progress-checks on radiologically treated prostatic carcinomas,
      however, needle biopsy with the Tru-Cut needle is clearly superior to aspiration
      biopsy. Cytologic and histologic progress-checks reveal that the local therapy
      effect of the measures were applied were directly dependent on the primary degree
      of differentiation. No improvement in the therapy-effect is to be achieved by the
      use of high-voltage radiation, especially in cases of undifferentiated carcinoma
      of the prostate. The clinical course is also largely determined by the primary
      degree of differentiation, and 20 % of stage C patients tend, with or without
      radiation-treatment, to rapid metastasisation, although the local tumour may have
      partically disappeared after such treatment. The plasmatestosterone level could
      be related neither to the local therapy-effect nor to the clinical course,
      whereas the enzyme-status in numerous cases coincided with the clinical history,
      though not with the cytologically or histologically determined therapy-effect. We
      could not establish any radiologically induced typical therapy-effect on the
      prostatic carcinoma either by cytological or histologic means.

PMID- 1023216
TI  - A critical review of histochemical and electromicroscopical studies of total
      prostatectomy specimens.

PMID- 1023217
TI  - Prostatitis.

PMID- 1023218
TI  - The prostatic antibacterial factor: identity and significance.

PMID- 1023219
TI  - Prostatitis: congestion, T-mycoplasma infection.

PMID- 1023220
TI  - Difficulties of treatment in the chronic prostatitis.

PMID- 1023221
TI  - Anatomy and dynamics of bladder neck.

PMID- 1023222
TI  - New technic for in-vitro testing of nasal preparations on the vibrating cilia of
      the mouse trachea.

PMID- 1023223
TI  - [Comparative pharmacokinetic study of 2 galenic forms of nicotinic acid].

PMID- 1023224
TI  - [Alkaloids of Chaenorhinum species (Scrophulariaceae)].

PMID- 1023225
TI  - [Glycyrrhizic acid determination in radix liquiritiae. Comparison of various
      methods].

PMID- 1023226
TI  - Lecithin as an antifoaming agent.

PMID- 1023227
TI  - The determination of certain delta4-3-ketosteroids in some parenteral
      formulations by differential pulse polarography.

PMID- 1023228
TI  - [Application and theoretical development of pharmaceutical forms for controlled
      liberation using methacrylic films. Preliminary communication. Fabrication and
      evaluation of free film plans].

PMID- 1023229
TI  - Effects of food restriction and mutation on central catecholamine levels in
      genetically obese mice.
AB  - Norepinephrine (NE) levels in the hypothalamus and telencephalon of genetically
      obese mice with the OBOB and DBDB mutations are significantly higher than those
      of their lean littermates. Obese mice with the viable yellow mutation failed to
      show this increase. Restricting the diets of OBOB animals to prevent excessive
      weight gain does not affect NE levels in the hypothalamus, telencephalon or
      brainstem.

PMID- 1023230
TI  - Actions of repeated injections of LSD and apomorphine on the copulatory response
      of female rats.
AB  - LSD, a serotonin receptor stimulating agent, inhibits copulatory behavior
      (lordosis response) in the ovariectomized and estrogen + progesterone treated
      female rat. The same effect is obtained by apomorphine, a dopamine receptor
      stimulating compounds. The lordosis has been shown to be dependent on serotonin,
      but also dopamine has been implicated in its mediation. Tolerance develops to
      certain responses after repeated injections of LSD and in the present study the
      influence of apomorphine and LSD was compared, when given in repeated doses.
      Possible cross-tolerance between the two compounds was also tested on the
      frequency of lordosis responding in ovariectomized and hormone treated female
      rats. Tolerance to LSD develops over seven days, while the suppressing influence
      of apomorphine on lordosis in seven repeated doses is not significantly altered
      from that of a single dose. No cross-tolerance was observed on the lordosis
      response with either order of treatments. Repeated doses of LSD did not influence
      locomotor activity differently from a single dose, while repeated doses of
      apomorphine enhanced this response in comparison with the effect of an acute
      dose. These results indicate differential sensitivity to the repeated treatments
      and further support an interpretation of the LSD effects on lordosis responding
      to be primarily on serotonergic rather than dopaminergic receptors.

PMID- 1023231
TI  - Drinking induced by parenteral injections of pilocarpine.
AB  - Parenteral (IP) injections of pilocarpine, in doses from 3.75 - 30 mg/kg,
      reliably produced drinking in water-satiated rats. This effect was not diminished
      by pretreatment with either centrally active (scopolaime, atropine) or
      peripherally active (methyl scopolamine, methyl atropine) cholinergic blocking
      agents, suggesting that pilocarpine does not induce drinking via a cholingergic
      meachnism. Repated injections of low doses, but not high doses, of pilocarpine
      augments drinking over trials.

PMID- 1023232
TI  - Marijuana and memory impairment: the effect of retrieval cues on free recall.
AB  - In an attempt to ascertain the effect of retrieval cues on recall deficits which
      occur following intoxication with marijuana, 40 male volunteers were presented
      with word lists following the smoking of a single one gram marijuana (0.94% delta
      9 -THC) or placebo cigarette and then were required to recall these words
      immediately after presentation. Recall occurred under a condition in which cues
      representative of to-be-remembered words were present or in an uncued condition.
      Results indicated that recall was depressed following marijuana administration
      under both cued and uncued conditions with cues being only mildly effective in
      reversing the recall deficit. There was no increase in the number of internal
      intrusions under marijuana, but the number of external intrusions was
      significantly elevated under the cued conditions.

PMID- 1023233
TI  - Does tolerance develop to low doses of d- and l-amphetamine on locomotor activity
      in rats?
AB  - An observational study of the behavioural effects of chronic regimens of d- and l
      amphetamine was designed to investigate possible mechanisms underlying any
      parallel behavioural changes: (1) Accumulation of p-hydroxynorephedrine in
      noradrenergic nerve terminals; (2) Altered sensitivity of dopaminergic receptors.
      The study revealed that locomotor activity seen with low doses of both isomers
      (2.0 mg/kg d- and 6.0 mg/kg l-) decreased with chronic once daily treatment.
      However, this was accompanied by an increase in directed sniffing activity and
      the behaviour came to resemble that seen with higher doses of amphetamine (8.0
      mg/kg d- and 16.0 mg/kg l-). Nonsignificant decreases in locomotor activity and
      increases in directed sniffing to apomorphine administration were observed during
      chronic amphetamine treatment. These findings suggest that (1) p
      hydroxynorephedrine, a metabolite of d- but not 1- amphetamine, does not play an
      important role in these alterations in behaviour with chronic treatment and (2)
      the tolerance to amphetamine observed under these conditions is due to an
      increased, rather than decreased, sensitivity of the rats to amphetamine.

PMID- 1023234
TI  - Effects of response requirement upon human sedative self-administration and drug
      seeking behavior.
AB  - Five male volunteers with histories of sedative drug abuse were given the
      opportunity to self-administer up to 20 oral doses per day of either diazepam (10
      mg per dose) or sodium pentobarbital (30 mg per dose). Each dose was purchased
      with tokens earned by exercising on a stationary exercise bicycle. Each two
      minutes of exercise earned one token. In a mixed order across days the number of
      tokens required to purchase each dose was varied among 1, 3, 5, 8 and 10. Drug
      intake decreased as a function of increased response requirement for purchasing
      the drug. Response output for drug tended to be an inverted-U shaped function of
      the response requirement. Thus, the cost of drug doses act as a powerful
      environmental influence upon both of these aspects of drug abuse behavior -
      amount of drug consumed and amount of drug-seeking behavior.

PMID- 1023235
TI  - Enkephalin and a potent analog facilitate maze performance after intraperitoneal
      administration in rats.
AB  - Met-enkephalin and its analog [D-Ala2]-Met-enkephalin-NH2 were administered
      intraperitoneally (IP) at a dose of 80 microng/kg body weight to hungry rats
      which were tested over 3 days for their ability to run a complex, 12 choice
      Warden maze for a reward of food. Animals receiving either peptide negotiated the
      maze significantly (p less than 0.01) faster (74.1 and 73.5 vs. 128.8 sec) and
      made significantly (p less than 0.01) fewer errors (5.5 and 5.4 vs 9.1) than
      animals receiving the diluent vehicle. These findings did not seem to be
      explained by differences in appetite, thirst, olfaction, or general activity.
      Rats injected in a preliminary study with an analog, [D-Phe4]-Met-enkephalin,
      which has essentially no opiate activity appeared to run the maze as fast as rats
      injected with [D-Ala2]-Met-enkephalin-NH2 and with just as few errors. Injection
      of morphine seemed to result in slower running times and more errors in the maze.
      These results demonstrate that enkephalin and some of its analogs can exert
      significant behavioral changes after IP administration and that these behavioral
      effects probably can be dissociated from the opiate effects.

PMID- 1023236
TI  - Cocaine and morphine self-administration: effects of differential rearing.
AB  - Two groups of Wistar rats were reared in either enriched or impoverished
      conditions for 100 days postweaning. These two groups were further divided and
      tested for cocaine or morphine preference in a two-bottle choice (water
      alternative) for 16 days. Enriched and impoverished rearing has previously been
      found to alter emotionality, conditionability, and body weight of adult rats.
      Validating previous reports of differential rearing effects on body weight, the
      enriched animals in the present study weighed less than their litter mates reared
      in impoverished conditions. Animals reared in the enriched environment consumed
      significantly more cocaine than animals reared in an impoverished one. No
      significant differences were observed for morphine self-selection as a result of
      differential rearing.

PMID- 1023237
TI  - Differences in cytochrome P-450 of various strains of rats following chronic
      administration of pentobarbital.
AB  - Cytochrome P-450 levels were analyzed in rats of two pigmented (black Long-Evans
      and ACI) and two albino strains (Fischer 344 and Sprague-Dawley) following the
      administration of pentobarbital sodium and physiological saline. Differences
      between the albino vs pigmented strains were observed following injections of
      saline. The Fischer 344 albino strains responded similarly to the pigmented
      strains following a progressively increasing dose schedule of pentobarbital
      sodium.

PMID- 1023238
TI  - [Current problems in the research on active substances. 12. Mechanism of action
      and structure-activity relationships of herbicides of the urea, carbamate, amide
      and triazine types].

PMID- 1023239
TI  - [Synthesis of N-[amidinobenzyl]-2-pyridones and 2-quinolines as well as of N
      [amidinobenzyl]-4-aminopyridinium salts].

PMID- 1023240
TI  - [Reactions with pyridinium pyruvic acid esters].

PMID- 1023241
TI  - Synthesis and screening of some substituted 3.5-dioxopyrazolidines.
AB  - Seven new 3.5-dioxopyrazolidine derivatives, incorporating in their molecule a p
      substituted benzoyl grouping, were synthesized. The preliminary screening of four
      selected compounds showed that 1-phenyl-2-[p-nitrobenzoyl]-4.4-diethyl-3.5
      dioxopyrazolidine possesses a low order of antiinflammatory activity.

PMID- 1023242
TI  - [A potential coccidiostatic 1-acyl-6-nitro-3-methyl-1H-indazole].

PMID- 1023243
TI  - [Evaluation of factors acting on the drug release of tenside-containing
      hydrocarbon gels].

PMID- 1023244
TI  - On the solubilization properties of surfactant-polymer complexes.
AB  - Polyethylene glycol (PEG) and polyvinylpyrrolidone (PVP) affect the
      solubilization properties of sodium dodecyl sulphate (SDS). When these polymers
      are added to SDS solution, its solubilization power for riboflavin, khellin and
      propyl p-hydroxybenzoate is markedly decreased. In case of riboflavin and
      khellin, the polymer effect is more pronounced at high surfactant concentrations;
      for propyl p-hydroxybenzoate, the polymer effect is inversely proportional to the
      surfactant concentration. On the other hand, the solubilization power of SDS
      towards methyl and butyl p-hydroxybenzoate is greatly enhanced by PEG or PVP. In
      case of methyl p-hydroxybenzoate the effect of PEG is more pronounced at high
      surfactant concentrations; the effect of PVP is not significantly dependent on
      the surfactant concentration. For butyl p-hydroxybenzoate, the polymer effect
      decreases markedly with increasing surfactant concentration.

PMID- 1023245
TI  - [Resorption studies with purines. 4. In-vitro determination using Dibbern's (II)
      Desaga Resomat II].

PMID- 1023246
TI  - [Interactions between macromolecular adjuvants and drugs. 4. Association
      tendencies between polyvinylpyrrolidone and oxytetracycline].

PMID- 1023247
TI  - [The preparation of drug-containing bead polymerizates on polyacrylate bases].

PMID- 1023248
TI  - [Drug permeation through synthetic lipoid membranes. 9. Studies on the appearance
      of diffusion layers in relation to membrane composition and permeating drugs].

PMID- 1023249
TI  - [The working mechanism of local anesthetics. 8. Preparation of enantiomer N
      phthalylamino carbonic acids].

PMID- 1023250
TI  - [Variability in the lanatoside C content of harvested leaves and drugs of
      Digitalis lanata Ehrh].

PMID- 1023251
TI  - [Triterpenes of Cucurbita lundelliana].

PMID- 1023252
TI  - [A method for the purification of Wilzbach-labelled 3H-mephentermine].

PMID- 1023253
TI  - Phytochemical and botanical study of Gynandropsis spp. Part 1: Gynandropsis
      glucosinolates.

PMID- 1023254
TI  - Furocoumarins part 3: Esters and ethers with predictable skin-photosensitizing
      activity.

PMID- 1023255
TI  - [Quantitative determination of ambazone].

PMID- 1023256
TI  - Volumetric determination of hexamine in some pharmaceutical preparations
      containing peperazine.

PMID- 1023257
TI  - [Testing the stability and purity of drugs using gas chromatography. 1.
      Determination of methanol as a possible impurity in tinctures and extracts].

PMID- 1023258
TI  - [Thin-layer chromatographic separation of reaction products formed during
      nitration in nitrazepam synthesis].

PMID- 1023259
TI  - [Antiviral isatin-3-thiocarbonylhydrazones and -isothiosemicarbazones and related
      compounds].

PMID- 1023260
TI  - [Synthesis and testing of potential antiparkinson agents. 1. Biolgocially active
      silicone compounds].

PMID- 1023261
TI  - [Preparation of 1-(2-nitrovinyl)-pyrazole derivatives].

PMID- 1023262
TI  - Synthesis of 1.4-naphthoquinones-4-aryl(aroyl)hydrazones of potential
      antimicrobial activity.
AB  - The isolation of phthiocol (3-hydroxy-2-methyl-1.4-naphthoquinone) from the
      acetone-soluble fat fraction of tubercle bacilli [1, 2] and the confirmation that
      it had antituberculous activity against H-37 R.V. strain [20] in vitro and in
      mice [12], prompted the synthesis of some 2-alkyl-3-hydroxy-1.4-naphthoquinone-4
      aryl(aroyl)hydrazones as possible tuberculostatic agents.

PMID- 1023263
TI  - [Problems in the use of plastic containers for liquid pharmaceuticals. 22. The
      oxygen permeability of pharmaceutically used polyethylenes studied by gas
      potentiometric methods].

PMID- 1023264
TI  - [Reaction of alpha-amino acids with quinonesulfonic acids].

PMID- 1023266
TI  - [Modification of the solubilizing properties of non-ionogenic tensides by
      hydratable compounds].

PMID- 1023265
TI  - Polysalt flocculates as a physicochemical approach in the development of
      controlled-release oral pharmaceuticals.
AB  - In the field of pharmaceutical formulation, polysalt flocculates have received
      relatively little attention in the literature. Accordingly this investigation
      could be considered an approach towards the development of oral controlled
      release dosage forms by polysalt flocculates. The polymer selected for this study
      was sodium carboxymethylcellulose. This was based on the fact that it forms an
      insoluble complex with aluminium sulphate, which could be of value in controlling
      the liberation of the entrapped drug. Drug entrapment was effected by polymeric
      flocculation, induced by the addition of a physiologically inert electrolyte.
      Results of this study indicated that this approach provided a physicochemical
      method for controlling drug release from oral pharmaceuticals, that could be
      claimed to replace the earlier empirical mechanical methods.

PMID- 1023267
TI  - [Determination of drug-tenside interactions using gel filtration].

PMID- 1023268
TI  - The fate of Depogen in rats.
AB  - Studying the metabolism of Depogen in rats we have worked out a method for the
      purification, isolation and separation of the drug and its potential metabolites.
      In the basic fraction we have found the same metabolic pathway of Drotaverin
      published earlier by us. In the focus of our recent work was the fate of the
      theophylline-7-acetic acid and its eventual biotransformed products. We have
      stated that theophylline-7-acetic acid contrasts with the theophylline excresa in
      unchanged form, which has been confirmed by several methods.

PMID- 1023269
TI  - [The action mechanisms of local anesthetics. 9. N-aminoacyl-beta-phenylalkylamine
      tested for development of antidepressive agents from psychotonics].

PMID- 1023270
TI  - [Isolation of betulic acid 3-O-beta-D glucoside, a saponin of Eryngium
      bromeliifolium Delar. 26. The contents of Saniculoidease].

PMID- 1023271
TI  - Thin layer chromatographic technique for the separation and identification of 1.4
      benzodiazepine drugs in biological material.

PMID- 1023272
TI  - Isolation of two flavonoids from Achillea santolina L. growing in Egypt.

PMID- 1023273
TI  - [A new method for the determination of epinephrine and its decomposition
      products. 1. The stability of phenylalkylamines].

PMID- 1023274
TI  - Pitch control and pharynx with in Twi: an electromyographic study.
AB  - The author examined electromyographic tracings from four muscles--genioglossus
      (GG), anterior belly of the digastric (D) sternothyroid (ST) and thyrohyoid (TH)-
      for 210 Twi syllables selected so as to give information on seven parameters:
      tense/lax vowels, long/short vowels, close/open vowels, front/back vowels, high
      tone/low-tone vowels, vowels preceded by a fricative/plosive consonant and vowels
      preceded by a voiced/voiceless consonant, and concluded, inter alia (1) that GG
      and D functioned as pitch control muscles but that it is not clear why raising of
      the larynx should accompany an increase in pitch; (2) that GG did not play the
      major role in tongue root fronting that was expected of it but that we may have
      to consider GG to consist of at least four functional muscles; (3) that GG and D
      offered little evidence to support a prosodic view of vowel harmony in Twi, and
      (4) that features may be ranked by the muscle activity associated with them and
      that 'high-tone', 'fricative' and 'voiced' dominated for GG, D and ST.

PMID- 1023275
TI  - [Statistical and dynamic analysis of crime in relation to primary dimensions in
      various countries].
AB  - The examination of the effects of social change on crime has experienced a
      revival of interest in the past decade. With the increasing availability of cross
      national data such analyses are being done in a comparative perspective. The
      current effort is designed to examine the relationship between three variables
      which have been shown to be empirically and theoretically pertinent to the study
      of social change and crime indices. Specifically, the variables of population,
      gross national product per capita and political orientation are regressed on the
      homicide rates, property crime rates and total crime rates for a number of
      countries. This analysis is done statically for 1965 and dynamically, for the
      change in the variables from 1960 to 1965. The data for the independent variables
      were acquired from the World Handbook of Political and Social Indicators, Second
      Edition. The source of the dependent variables was the International Crime
      Statistics published by the International Criminal Police Organization
      (Interpol). The problems with such data are recongized and discussed. The results
      indicate that in the static analysis the three variables explain a substantial
      amount of the variance in property crime rates and total crime rates whereas they
      do not explain much of the variance in the homicide rate. Gross national product
      per capita contributes the most to the explained variance in all the analyses. A
      theoretical perspective combining the ideas incorporated in control theory and in
      environmental opportunity theory was employed to account for the results. The
      results of the dynamic analyses parallel those of the static analyses, with the
      exception of the equation employing the total crime rate at the dependent
      variable. The total variance explained in this equation was significantly lower
      than in the static analysis for the total crime rate. Durkheim's notions of the
      functions of crime and the expected stability in crime rates were offered as an
      explanation for this finding.

PMID- 1023276
TI  - [Alternative imporisonment measures in the penal legislation of the Socialist
      Republic of Poland].
AB  - On April 19th, 1969 the People's Poland Parliament adopted a new penal
      legislation consisting of a Penal Code, a Code of Criminal Procedure and an
      executory Penal Code, which all came into force January 1st, 1970. The
      distinctive peculiarity of the above mentioned Codes, as the Authors have pointed
      out, is that they conform to the recent political, social and economic
      democratization of Poland and to the structure and dynamics of delinquency in
      this country. In examining the measures concerning educational rehabilitation
      provided for by the penal law in question, the Authors have started discussing
      questions like restriction on personal freedom, conditional suspension of
      criminal procedings, supervision of the convict who has been given the benefice
      of conditional suspension of the execution of sentence or of conditional release
      and supervision of the recidivist as well as points related to warranty and
      postjail care. Though these measures show some similarity to those provided for
      by bourgeois penal legislations, they result from a quite anthithetic ideology
      according to which punishment has to perform a double function of defence of
      working-class achievements as well as of an effective rehabilitation of the
      convict. A detailed analysis of the theoretical premises and of the actual
      carrying out of these measures shows, the Authors say, that though they represent
      only a further stage in the development of socio-juridical progress, they are put
      in conformity with the criminal policy's trends and the politico-ideological
      contents of a socialist government. They testify therefore an actual effort to
      make social rehabilitation of the convict possible in that they prevent the
      exertion of all negative psycho-pathogenic influences of jail environment on the
      convict, especially in case of slight crimes. The ultimate importance of these
      measures is that they can be considered an articulate attempt to promote actual
      social rehabilitation of the convict and therefore they are a real contribution
      in the resolution of delinquency which is viewed in Poland, where a process of
      socio-political trnasformation has been recently taking place, as part of the
      heritage from the past bourgeois government.

PMID- 1023277
TI  - [Penal institutions in Porto Azzuro].
AB  - Prior to describing the environmental and human situation of the Porto Azzurro
      penal Institutions, the Author devotes a chapter to the historical part and gives
      an outline of the most important events that, in 1600 or thereabouts, led to the
      construction of the Fort S. Giacoma (where the penitentiary is presently sited),
      which, after a number of vicissitudes and transfers of title, was finally
      destined for use, in 1900, as a prison establishment. The subsequent and, in
      particular, the recent building re-structurations, have radically changed the
      penitentiary in order to make it more in line with the functions required by the
      present prison policy. After describing the establishment's setup, which includes
      many institutes, the Author passes on to consider the problems of personnel and,
      in particular, of the military staff. In the central chapter on intramural life,
      he makes an in-depth review of the methods and means of treatment, some of which
      are proper of this particular environment. In illustrating such convicts'
      activities, as working, leisure time, education, relationship with the extramural
      world, the Author lays stress on the always present objective: that directed at
      helping convicts re-enter social life. In conjunction with health services and
      religious services, the Author deals at length with the delicate moment of the
      "audience", viewed as a therapeutic means indispensiable for establishing a valid
      re-educational contribution. The discipline and discharges conclude the
      description of the Porto Azzurro penal Institutions, whose environment and
      various treatment methods in use before the implementation of the new
      penitentiary System, are dealt with in detail by the Author.

PMID- 1023278
TI  - [Histochemical detection of polysaccharides in the Bowman's gland of the nasal
      mucosa of the albino rat].

PMID- 1023279
TI  - [The decline of fertility in western europe: I. -- the appraisal (author's
      transl)].
AB  - The sharp decline in the number of births these last ten years is a general
      phenomenon in Western industrialised countries. As far as methodology is
      concerned, a clear distinction must be made between two concepts measuring
      fertility: completed fertility of successive generations, total fertility rate of
      successive years. The evolution of these two indicators of procreative behaviour
      is amazingly comparablefrom country to country, in spite of their various
      difference in termes of economic situation, of legislation (family allowances,
      contraception, abortion, divorce), predominant religion, etc...

PMID- 1023280
TI  - [Genetical and epidemiological study of uricaemia in a Pyrenean population.
      (Region of Sault - Pyrerees audoises) (author's transl)].
AB  - Serum uric acid levels were determined in 229 individuals of Rodome and 127
      individuals of Camurace, in the french Pyrenees. The difference of average levels
      between these two populations was found to be due very likely to different way of
      life. Intra-familial correlations suggest a greater importance of environmental
      than genetic factors on serum uric acid levels.

PMID- 1023281
TI  - [New results on the phage typing of Yersinia enterocolitica, concerning more of 4
      000 strains of various origins (author's transl)].
AB  - 1) The phage typing of Y. enterocolitica has been made on more than 4,000 strains
      of various origins by means of 2 sets of phages. The 1st one, composed of 12
      phages extracted from lysogenic strains of the same species has permitted to
      distinguish 10 phages types numbered from I to VIII and from IXa to IXb among the
      3,323 lysotypable strains on the 4,366 examinated. 2) The search of the beta
      galactosidase has differentiated the phage type IXa in its 2 varieties, the IXa
      1, beta-galactosidase negative and the IXa 2, beta-galactosidase positive. 3) The
      1,043 untypable strains by the 1st set were forming 2 very different groups. One
      of them, the X was insensitive to the 12 phages of the 1st set; the other XI,
      showed such a variety of lytic reactions to the phages of the 1st set that it was
      impossible to consider the rare samples of each of them as phage types. 4) The
      group X, submitted to a "complementary phage typing" by means of a second set of
      phages isolated from sewage water, has been subdivised into about 20 undergroups,
      from which only, 7 have been studies up to now, numbered from X 1 to X 7...

PMID- 1023282
TI  - [Evaluation of technics used to define type 'A' pattern, in the Belgian
      Prevention Project of cardiovascular diseases (author's transl)].
AB  - In order to define the Rosenman and Friedman type A pattern three technics where
      used: the Bortner scale, the Jenkins Acitivity Survey (J.A.S.) and the interview.
      These are part of the base-line data recorded during the screening of a belgian
      male population aged 40 to 59 at entry of a controlled trial for the
      multifactorial prevention of cardiovascular diseases. The J.A.S. and the Bortner
      scale are evaluated in relation to the interview. Extremes of type A and B are
      less prevalent in our study compared to the Western Collaborative Group Study.
      Both the J.A.S. and the Bortner scale are very satisfactory in predicting type A
      and B pattern. The Bortner scale predicts the pattern in 78% of the subjects, by
      the method of weighted scores. The validation of this classification method, on a
      second sample, gives an accurate classification in 75% of the subjects. The
      J.A.S. predicts, the pattern in relation to the interview in 78% of the subjects;
      again the validation of the classification method, on a second sample, gives a
      correct classification in 70% of the subjects.

PMID- 1023283
TI  - [Radiations and public health (author's transl)].
AB  - A short review is made of the general characteristics of electromagnetic and
      corpuscular radiations to which man can be exposed. Following some considerations
      on the action of ionizing radiations and the radiobiological factors governing
      their effects on health, the overall characteristics of pathological effects
      differentiating stochastic from non-stochastic effects are summarized. The
      uncertainties remaining as to low-level exposures are stated as well as the
      cautious assumptions usually madein this field. The various sources of exposure
      to which the population is submitted are considered, i.e. exposures from natural,
      medical, domestic, industrial sources or from fallout from nuclear weapon tests;
      the present or predictable levels of exposure and their variations are given for
      each source. But for medical irradiation, all the exposures connected to human
      activities are much lower than natural exposure variations; such exposures should
      modify the incidence of certain affections but quite insignificantly as compared
      with the regional or local variations observed.

PMID- 1023284
TI  - [The possible reduction of sperm (author's transl)].

PMID- 1023285
TI  - [Indicators of atmospheric pollution (author's transl)].

PMID- 1023286
TI  - [Distribution and variation of the femoral artery].

PMID- 1023287
TI  - [Retroperitoneal malacoplakia. Report of a case].

PMID- 1023288
TI  - [Report of a case of combined pregnancy].

PMID- 1023289
TI  - [Didactic method for the morphological study of the osseous ear].

PMID- 1023290
TI  - [Application of the scientific method in the practice of medicine].

PMID- 1023291
TI  - [Surgical anatomy of the lower hepatic lobe].

PMID- 1023292
TI  - The role of the medical director of respiratory therapy.

PMID- 1023293
TI  - The impact of materials shortages on the respiratory therapist.

PMID- 1023295
TI  - Hospital smoking: policies, programs, and problems.

PMID- 1023296
TI  - The employment market.

PMID- 1023297
TI  - Research funding.

PMID- 1023298
TI  - All in the family: treating lungs or testing them--it's still RT.

PMID- 1023300
TI  - RT education: role for proprietary schools? Part I.

PMID- 1023299
TI  - Cystic fibrosis: a new challenge for the patient-care team.

PMID- 1023301
TI  - The malpractice threat: therapists are not immune.

PMID- 1023302
TI  - [Current status of surgery of the vidian nerve].

PMID- 1023303
TI  - [Current aspects of tuberculous otitis].

PMID- 1023304
TI  - [Comparative cochlear ototoxicity of 3 antibiotics: kanamycin, gentamicin,
      tobramycin. Histologic and ultrastructural study].

PMID- 1023305
TI  - [General concepts regarding angiography and therapeutic embolization].

PMID- 1023306
TI  - [2 cases of otogenic septicemia].

PMID- 1023307
TI  - [Electric stimulation of the stapedian reflex: presentation of a new stimulator,
      initial clinical results].

PMID- 1023308
TI  - [The profession of the hearing aid specialist and its limitations].

PMID- 1023309
TI  - [Nicotine poisoning and cancer of the larynx in Morocco. Statistical study of 500
      cases].

PMID- 1023310
TI  - [Effects of heparin upon complement (author's transl)].

PMID- 1023311
TI  - [The possible role of superoxide radicals as hemolytic agents in phenylhydrazine
      action (author's transl)].

PMID- 1023312
TI  - [Hemoglobin thermolability. Normal values (author's transl)].

PMID- 1023313
TI  - [Iron absorption and stores in young adults (author's transl)].

PMID- 1023314
TI  - [Hematologic studies in patients with subtotal gastrectomy (author's transl)].

PMID- 1023315
TI  - [Exploratory laparotomy with splenectomy for the identification of stages in
      Hodgkin's disease (author's transl)].

PMID- 1023316
TI  - [Paroxismal nocturnal hemoglobinuria (author's transl)].

PMID- 1023317
TI  - [Diphyllobothrium latum induced megaloblastic anemia (author's transl)].

PMID- 1023318
TI  - [Hormonal regulation of erythropoiesis (author's transl)].

PMID- 1023319
TI  - [Current aspects of chronic lymphocytic leukemia (author's transl)].

PMID- 1023320
TI  - [Functional pathology of neutrophils].

PMID- 1023321
TI  - [Hemoglobinopathies: frequency in 561 selected subjects (author's transl)].

PMID- 1023322
TI  - [General aspects of bronchopulmonary abnormalities].

PMID- 1023323
TI  - [A concept of amniotic fluid of physiology based on the ultrastructure of the
      membranes of the ovum (author's transl)].

PMID- 1023324
TI  - [An index of fetal age based on four components of amniotic fluid (author's
      transl)].

PMID- 1023325
TI  - [The effects of synthetic oxytocin infusions on neonatal blood bilirubin levels
      (author's transl)].

PMID- 1023326
TI  - [Ovarian dystrophy which is hypothalamo-hypophyseal in origin (author's transl)].

PMID- 1023327
TI  - [Colposcopical and histological aspects of cervical infections (author's
      transl)].

PMID- 1023328
TI  - [Oral contraception by means of progestagen-only micropills taken continuously in
      the light of four recent trials (author's transl)].

PMID- 1023329
TI  - [Concentration of metampicillin in the maternal blood, fetal blood and in the
      amniotic fluid].

PMID- 1023330
TI  - [Experimentation on the combination of estrone monosodium sulfate and estradiol
      monosodium sulfate in the treatment of menopause].

PMID- 1023331
TI  - Cytochemical investigation on lipids in human major salivary glands. A light and
      electron microscope study.
AB  - The localization of lipids in the secretion of human parotid and submandibular
      glands has been here investigated. Ultrastructural observations following lipid
      extraction and histochemical data showed that lipid components are not present in
      the secretory granules. In fact, while histochemical reactions are completely
      negative, secretory granules from lipid-depleted glands retain all their
      morphological characters. These results led us to emphasize that, at least in
      human seromucous cells, lipids are not directly involved in the salivary
      secretion. This conclusion, which is supported by the biochemical data concerning
      the lipid content in human saliva, disagrees with the findings obtained in rat
      and guinea pig salivary glands. However, this discrepancy may be ascribed to the
      specific biochemical and ultrastructural differences found in the salivary glands
      of the various mammalian species.

PMID- 1023332
TI  - [Quantitative limits of the Feulgen reaction: analysis of interference caused by
      dehistonization and denaturation and renaturation treatments].
AB  - The Feulgen reaction intensity (measured with a microdensitometer Vickers M86 on
      the nucleus of erytrocytes of Xenopus laevis Daud.) is increased after
      dehistonization according to Brody (1974) only if the dehistonization is made
      before the fixation in acetic acid. The denaturation and renaturation treatments
      which should act specifically on the screws of the DNA and therefore should not
      affect the Feulgen reaction, act in a specific manner, probably going away
      another histonic components. On the dehistonized material the action of the
      hydrolysis of the Feulgen reaction would add up to that implicit in the
      dehistonization treatment and would cause a rapid fall of the values for loss of
      material as consequence of depolymerization facts, according to Andersson and
      Kjellstrand (1975). The successive renaturation treatment both on dehistonized
      and on non dehistonized material does not change significantly the values
      precedently obtained and this confirms the idea that the rilevability of the
      Feulgen reaction is not influenced by the treatments "per se" but by the deep
      "touching" of the chromatin components.

PMID- 1023333
TI  - [Some cytochemical characteristics of the chromatin in the erythrocytes of
      Xenopus laevis Daud].
AB  - The Xenopus laevis Daud. genome offers a stimulating model of a chromatin
      (Davidson et al., 1975) in which a high ratio of repetitious DNA sequences has
      been recorded (45% of total genome according to Davidson et al., 1975). We have
      studied cytochemically this model "in situ", on the erythrocytes of air-dried
      smears of peripheral blood. The cells, which are non-dividing and not engaged in
      DNA reduplication, constitute almost hypothetically a homogeneous class
      constantly in G1 phase of the cellular cycle. Our methods are: a) analysis on the
      curves of Feulgen hydrolysis kinetics to attempt to find the depurination and
      depolymerisation patterns of DNA according to Andersson et al. (1975); b)
      determination of the DNA resistence ratio to chemical denaturation with a
      quantitative relative microdensitometric determination of methyl-green staining,
      according to Scott (1967) specific technical conditions. For comparison,
      qualitative and preliminarly subjective control determinations have been made
      with acridine-orange in correspondent denaturation conditions. Both the a) and b)
      methods have been performed with and without previous HCl dehystonisation and
      with and without formaldehyde pretreatment. The results with the a) and b)
      methods have not yet been theoretically compared and the possibility of an
      approach to this correlation is discussed here as a tool for a possible
      cytochemical quantitative measure of the nuclear fraction of repetitious DNA "in
      situ".

PMID- 1023334
TI  - [Histochemical studies of the endocrine cellular components of swine duodenal
      glands (Brunner's glands)].
AB  - The AA. describe an endocrine cells presence in the Pig Brunner's duodenal glands
      by means of histochemical methods at light microscope. Between these they can
      recognize two types of cells: these enterochromaffins (EC) and these non
      enterochromaffins (non-EC), both presents either in the secretory part of the
      glands or in the deeper parts of the ducts. The EC-cells show generally a
      prismatic size and their apical part attains the glandular cavity. Their granules
      are much numerous and recognizables either in the basal part or in other parts of
      the cells. The non-EC-cells show a variable, from the prismatic to the
      spheroidal, size. Their granules are numerous and recognizables mostly in the
      basal part of the cells. Between the non-EC-cells they can also differentiate at
      least three types: a) these Davenport-positives and poorly argyrophils; b) these
      Davenport-positives and clearly argyrophils and c) these Davenport-negatives and
      clearly argyrophils. All cells are by lead-haematoxylin stainables, while by the
      HCL-BT method the EC-cells are ortochromatics and these non-EC are
      metachromatics.

PMID- 1023335
TI  - [Morphological and histochemical aspects of the argentaffin and argentophilic
      cells in the gastric mucosa of Scyliorhinus stellaris and Scyliorhinus canicula].
AB  - Using histological and histochemical methods for the identification of biogenic
      amins, phenolic and indolic groups, and of substances with a proteine and
      carbohydrate nature, it has been possible to identify at least five types of
      endocrine cells in the gastric mucose of Scyliorhinus stellaris and Scyliorhinus
      canicula. One of these, a type I cell, localised mainly in the piloric portion,
      shows morphological and histochemical characteristics which are perfectly
      comparable with those of the enterochromaffin type found in the gastro-intestinal
      tract of mammals. On the other hand, the four remaining cellular types are more
      difficult to define; three of these latter are present solely in the pyloric
      mucose, i.e., (a) type II cells with slightly fluorescent and metachromatic
      granules, with a positive reaction to the Grimelius test and to proteine test,
      and completely negative and argentaffin methods, (b) type III cells with non
      fluorescent granules, but metachromatic and postive to argentaffin methods, and
      (c) type IV cells with slightly (argyrophilic) granules, strongly metachromatic
      and positive to the PAS test and to the tryptophan test, respectively. Types II
      and IV have been hypothetically correlated with the G and D cells, respectively,
      of mammals. The fifth cellular type, present solely in the central portion of the
      stomach has exclusively argyrophilic granules. This latter cellular type is
      considered similar to the ECL type, mammalian cell. No hypothesis, however, has
      yet been ventured with respect to the cells belonging to the third group.

PMID- 1023336
TI  - [Histochemical demonstration of uridine diphospho-glucoso-4'-epimerase activity].
AB  - In the byosinthesis of glycosaminoglycans, UDP-glucose is utilized by two
      enzymes: UDP-glucose dehydrogenase which produces UDP-glucuronic acid
      (chondroitin sulphate precursor), and UDP-glucose 4'-epimerase which produces UDP
      galactose (keratan sulphate precursor). The mechanisms regulating these two
      reactions have particular interest mainly considering that many connective
      tissues can modify its glycosaminoglycan production with aging; it is well-known
      that cartilage of young animals synthesizes almost exclusively chondroitin
      sulphate while cartilage of old animals synthesizes both chrondroitin sulphate
      and keratan sulphate. The kinetic parameters of both enzymes utilizing UDP
      glucose have been recently investigated and some mechanisms responsible for UDP
      glucose utilization in glycosaminoglycan biosynthesis have been evidenced. Under
      histoenzymological viewpoint, we have confirmed the inhibiting effect of UDP
      xilose on UDP-glucose dehydrogenase and the possible role of such nucleotide in
      aging processes of cartilage. In order to study this problem even by a
      histoenzymological approach, an original method for histochemical determination
      of UDP-glucose 4'-epimerase activity in connective tissue cells was developed.
      This method seem to be more sensitive than that described by other authors. In
      standard conditions the sections of the frozen tissue were incubated in Tris-HCL
      buffer, pH 8.8 (Tris concentration 0.025 M), containing 0.5 mM UDP-galactose, 2
      mM NAD, 0.6mM NBT and an excess of UDP-glucose dehydrogenase (about 300 mU).
      Control experiments in the absence of UDP-galactose, UDP-glucose dehydrogenase
      and in the absence of both UDP-galactose an- UDP-glucose dehydrogenase were also
      carried out. Under our experimental conditions, UDP-glucose 4'-epimerase present
      in the cells epimerizes UDP-galactose (added in the incubation mixture) to UDP
      glucose which can bo oxidized by the excess of UDP-glucose dehydrogenase to UDP
      glucuronic acid with a consequent NADH formation. The NADH formed is able to
      reduce and precipitate NBT. As a control of experimental sistem, we have
      determined the increase in O.D. at 525 nm of a reaction solution that was
      incubated directly in the spectrophotometer cuvette, at 37 degrees C with UDP
      galactose 0.2 mM, NAD 2 mM, NBT 0.6 mM, 200 mU of UDP-glucose, dehydrogenase,
      400mU of UDP-glucose 4'-epimerase and Tris HCL buffer pH 8.8 to a final volume of
      1 ml. Histoenzymological and biochemical results demonstrate that this method is
      specific for and sensitive to UDP-glucose 4'-epimerase activity.

PMID- 1023337
TI  - [Distribution of the enterochromaffin ("EC") cells and those of the "APUD" series
      in the gastrointestinal tract of ruminants].
AB  - The research was carried out on the vorestomachs, abomasum and on the various
      tracts of gut of adult Cattle, Sheep and Goat, because Ruminants, not previously
      studied with respect to this problem, have, as is well known, particular morpho
      functional characteristics of the digestive system. The results can be
      synthetized as follows: 1) either "EC" (5-HT-producing) or "APUD" cells (peptide
      hormones-producing) are not demonstrable in the vorestomachs. 2) "EC" cells are
      present in the various areas of abomasum (particularly numerous in the fundus
      glands) and in the different tracts of the gut (predominantly in the duodenum and
      in the rectum). 3) In the "APUD" cells of the abomasum gastrin-producing "G"
      cells are certainly demonstrable. They are present only in the pyloric glands,
      where they prevail in the middle third. Only in the cattle, cells which have all
      the histochemical characteristics of "G" cells, but are quite morphologically
      different, are also present in the same area. An interesting peculiarity seems to
      be the reduced number of "APUD" cells, compared with that of Monogastrics: it was
      impossible, in fact, to demonstrate some cells ("A", "A-like","X", "D", "D1",
      "ECL") which are described by other Authors in the stomach of various Mammals. 4)
      In the small intestine, endocrine cells, probably heterogenous are present,
      resulting more numerous in the duodenum. 5) In the coecum, colon and rectum,
      cells comparable to enteroglucagon-producing "EG" cells, are present; they are
      particularly numerous in the rectum, where cells similar to "H" cells are also
      present.

PMID- 1023338
TI  - [Distribution of the enterochromaffin ("EC") cells and those of the "APUD" series
      in the gastrointestinal tract of the calf].
AB  - Based on morphological and histochemical data, the Authors describe the
      distribution of "EC" (5-HT-producing) and of the other endocrine cells of the
      "APUD" series (polypeptide hormone-producing) in the gastro intestinal tract of
      weaned and unweaned 3-4 month old calves. The results demonstrate that: -- no
      difference concerning the different diet can be correlated; -- no endocrine cell
      is present in the vorestomachs; -- the "EC" cells in the abomasum prevail in the
      fundus glands; they are demonstrable also in every tract of the intestine and are
      more numerous in the duodenum and in the rectum; -- within the "APUD" series four
      cellular types are demonstrable in the abomasum; two are in the cardias, one in
      the fundus and one in the pylorus glands; the last one probably corresponds to
      the gastrin-producing "G" cells. -- In the small intestine, particularly numerous
      in the duodenum, a probably heterogeneous family of endocrine cells is present,
      while in the coecum, in the colon and, above all, in the rectum, cells probably
      corresponding to "EG" cells are identifiable. These results are compared to those
      previously obtained in the adult Cattle: remarkable differences are demonstrable
      only within "APUD" cells of abomasum.

PMID- 1023339
TI  - [Cerebrospinal fluid immunoglobulins and neurological diseases].
AB  - Then is reported a new inexpensive and easy method to analyse the CSF
      concentration of immunoglobulins in some neurologic disease (in particular in the
      multiple sclerosis). The obtained data were in according with similar results of
      other Author, which used more sophisticated techniques. The increase of IgG in
      multiple sclerosis (72,7%) suggested us to consider this analysis now very useful
      for a correct diagnosis. The reason of CSF IgG increase in multiple sclerosis is
      discussed.

PMID- 1023340
TI  - [Nonpharmacological, ubiquitous, rapid, fused graphic elements in the
      electroencephalographic pattern of 2 sisters with type A sulfatidosis and ponto
      cerebellar systemic atrophy].
AB  - Two sisters, affected by late infantile type Sulfatidosis A, died at 22 and 15
      years old respectively, presented, after autoptic examination, also a ponto
      cerebellar athrophy. The EEG finding was characterized by few bioelectric
      abnormalities in the earlier studies of the disease and, afterwards, a
      progressive slower electric activities, with isolated asymmetric spikes. The
      typical aspects in the EEG recordings of our two patients were the presence of
      many rapid and diffuse elements, shay wawes without any pharmacological
      treatment. The significance of these peculiar recordings is there discussed.

PMID- 1023341
TI  - [Reaction to awakening from sleep in children (electroencephalographic study of
      153 subjects)].
AB  - The arousal reaction has been studied on the EEG records of 153 children aged
      within 1 and 4 and observed suffering from different neuropsychiatric disorders.
      In the majority of the patients the arousal was accompanied by diffuse paroxysmal
      modifications that are present both in the records of clinically epileptic
      children and in those having never suffered of epileptic seizures.

PMID- 1023342
TI  - [The world of the epileptic: anthropo-phenomenological considerations].
AB  - After pointing out that in literature studies concerning the anthropo
      phenomenologic aspects of the existence of subjects suffering from epilepsy are
      very scanty, the Authors dwell upon the opportunity of deepening this study which
      may allow a better knowledge of the complex problems of the patient. These
      problems should be neglected if only the biologic side of the disease was taken
      into consideration.

PMID- 1023343
TI  - [Juvenile myasthenia gravis of possible post-vaccinal inoculation: study of 2
      cases].
AB  - The AA. describe two cases of serious juvenile myasthenia arisen after jennerian
      vaccination, antidiphteric and antitetanic vaccination in the first patient and
      after antitetanic vaccination in the second one. They put forward the hypothesis
      that in the two patients juvenile serious myasthenia is a complication due to
      vaccination for the following reasons: 1) the chronological relation between
      vaccination and the arising of myasthenic sumptomatology is very close; 2) the
      vaccine produces in the body a reaction of immunity type and myasthenia is
      nowadays generally considered as an immunity disease. Although the ways in which
      the vaccine inoculation can give rise to the disease are unknown, it can be
      supposed that in the occurrence at the same time of a genetic factor or of an
      susceptible area, the vaccine can act as a factor provoking the immunity answer
      of myasthenic type.

PMID- 1023344
TI  - [Clinical study of dantrolene sodium in the treatment of spastic and dystonic
      syndromes].
AB  - Dantrolene sodium has been given to 45 patients suffering from dyskinetic
      syndromes: 33 were suffering from spastic syndromes, either secondary to cerebral
      lesions at birth, or to other cerebral lesions, or to cord lesions; 9 were
      affected by infantile dystonic syndromes; 1 by dystonia muscolorum deformans and
      the last 2 patients were suffering from parkinsonism. The best dosage schedule
      was individual and ranged from 50 mg to 300 mg a day. In this range, the majority
      of the spastic patients showed reduction of spasticity, unrelated with the site
      of pathology: a slight one in 12 patients, a moderate one in 9 and a marked one
      in 2. On the contrary, slight improvement has been noticed in only two of the
      patients suffering from dystonic syndromes. In no case side effects has been
      noticed. In all patients who underwent slight or moderate improvement only, we
      tried to obtain better results on spasticity by growing the dosage schedules; but
      we have always noticed side effects, that is weakness or drowsiness and,
      sometimes, urinary uncontinence. Moreover 2 patients showed evidence of
      transitory metabolic side effects. Therefore our experience shows that dantrolene
      sodium is an useful drug into the therapy of spasticity, even if often a slight
      of moderate improvement only is achieved. Slow increase in dosage schedule,
      repeated laboratory controls and alternate periods of treatment and suspended
      treatment should be observed.

PMID- 1023345
TI  - [Takeuki and Nishimoto's syndrome: an angiographic and nefrographic study of one
      case (author's transl)].
AB  - Takeuki and Nishimoto's syndrome has been described as more common though not
      exclusive in the Japanese people; it occurs in the pediatric or young adult age.
      The clinical syndrome is most variable (transitory ischemic attacks or
      circulatory insufficiencies with permanent neurological deficit, as well as
      subarachnoid hemorrhage). Conversely, the angiographic syndrome is quite typical:
      I) stenosis of both internal carotid arteries and the anterior part of Willis
      circle; II) presence of an angiomatous net at the level of the basal ganglia;
      III) presence of several anastomosis between internal and external carotid
      arteries. The essential pathogenetic event seems to be the slow occlusion of the
      two internal carotid arteries and of the anterior part of the anterior part of
      the circle of Willis of unknown aetiology. The observations reported in the
      present article cover angiographic, nefrological, microbiological, metabolic and
      immunological studies in a clinical case of Takeuki and Nishimoto's syndrome.
      This was clinically revealed by a subarachnoid hemorhage, indicating that carotid
      stenosis may be a fairly selective process. The temporal evolution of such a
      process and the slow invasion of distal arterial segments support the
      interpretation of the process itself as not congenital.

PMID- 1023346
TI  - [Pourfour du Petit syndrome and intracranial aneurysms (author's transl)].
AB  - A 52 year old female suffered for more than 20 years from a recurrent pulsating
      headache on the left side. Clinical examination showed the retraction of the
      superior eyelid and mydriasis on the left. Exophthalmometry revealed 17 mm of
      protrusion for each eyeball. Angiographic investigations showed two little
      aneurysms: one of the anterior comunicating artery, the second of the left middle
      cerebral artery. In view of the clinical and angiographic findings the authors
      discuss the pathogenetic mechanisms of such oculo-sympthetic syndrome.

PMID- 1023347
TI  - [Lead arsenate as an underestimated cause of polyneuropathy in rural environment:
      description of two cases].
AB  - Two cases of lead arsenate polyneuropathy are described in two farmers from the
      same rural area; the etiology of the neurologic al disorder was ascertained only
      after repeated hospital admissions. It was a neuropathy of the radial nerve
      associated with signs of peripheral impairment of the lower limbs with pains and
      paresthesias. Abdominal colies, arterial hipertension, anaemia and signs of renal
      impairment were also present. Specific therapy was undertaken which was soon
      followed by nearly full recovery. Lead and arsenic toxicology are discussed with
      particular focusing on the necessity emphasis on commun occupational hazards both
      in terms of diagnostic and therapeutic procedures. The differential diagnosis is
      considered between the observed clinical picture and other polyneuropathies of
      different etiology i.e. dysmetabolic (porphyria) or toxic (insecticides,
      T.O.C.P., etc).

PMID- 1023348
TI  - [A case of prosopoagnosia (author's transl)].
AB  - A case of prosopoagnosia is described in a ten year old boy who was admitted to
      the Department of Neurosurgery in Parma, because of a cerebral contusion. This
      symptom is present in a number of patients with lesions involving the right
      hemisphere, particularly in post-rolandic injuries, often associated with left
      visual field defect, with directional and vestibular disturbances and
      metamorphopsia. This symptom may be interpreted as a defect which avoids
      simultaneous and them total acknowledgements. The acknoyledgement of human faces
      is an acquired ability susceptible to a regression to an infantile level.

PMID- 1023349
TI  - [Contingents of inhabitants of the city of Nikolaev not applying for medical
      services].

PMID- 1023350
TI  - [Growth of familial studies in Soviet medicine].

PMID- 1023351
TI  - [Pregnancy and its outcome among students at day divisions of the higher
      education institutions of Vil'nius].

PMID- 1023352
TI  - [State of the health of students' children].

PMID- 1023353
TI  - [Resolutions of the 25th Congress of the CPSU--guideline for action].

PMID- 1023354
TI  - [Role of sanitary culture in the prevention and treatment of hypertension].

PMID- 1023355
TI  - [Morbidity with temporary loss of work capacity in alcohol abusers].

PMID- 1023356
TI  - [Regarding the article by R.G. Neslukhovski "Problems in Planning the Work of a
      First-Aid Station"].

PMID- 1023357
TI  - [Experience with teaching Marxist-Leninist philosophy at a medical university].

PMID- 1023358
TI  - [Automated system for monitoring bed turnover in the Latvian SSR].

PMID- 1023359
TI  - [Experience of conducting hemodialysis in circulatory insufficiency in patients
      with acute and chronic renal incompetence].

PMID- 1023360
TI  - [DDAVP in the treatment of hypophyseal diabetes, nocturnal enuresis and in rapid
      determination of the concentrating function of the kidney].

PMID- 1023361
TI  - [Functional state of the kidneys in patients with acute renal insufficiency in
      the beginning of convalescence stage].

PMID- 1023362
TI  - [External biliary fistulas].

PMID- 1023363
TI  - [Echinococcus in the cellular tissue of the retroperitoneal space].

PMID- 1023364
TI  - [Hormonal correlations in pregnant women before delivery].

PMID- 1023365
TI  - [Influence of hormonal contraceptives on the renin-angiotensin-aldosterone
      system].

PMID- 1023366
TI  - [Diagnosis and treatment of adenomatous polyps of the rectum and large
      intestines].

PMID- 1023367
TI  - [Functional and morphological changes in the upper sectors of the alimentary
      tract in calculous cholecystitis].

PMID- 1023368
TI  - [Socio-hygienic significance of the aging process of the population].

PMID- 1023369
TI  - [Problems relating to dispensary treatment of nephrological patients].

PMID- 1023370
TI  - [Comparative data of glucocorticoid and androgenic function of the adrenal cortex
      in patients with peptic ulcer of resected stomach].

PMID- 1023371
TI  - [Changes in the duodenum in pancreatic pathology].

PMID- 1023372
TI  - [Determination of the amount of rehydration solution according to the area of the
      body surface in acute intestinal infections].

PMID- 1023373
TI  - [Biomycin electrophoresis in the treatment of erysipelous inflammation of the
      extremities].

PMID- 1023374
TI  - [Results of clinico-gynecological and dermatoglyphic studies in patients with
      polycystic renal disease].

PMID- 1023375
TI  - [Methodology of evaluating functional conditions of the kidneys in bilateral
      diffuse renal diseases].

PMID- 1023376
TI  - [Function of contralateral kidney in unilateral renal disease].

PMID- 1023377
TI  - [Present state and future prospects for the development of urological assistance
      in the RSFSR].

PMID- 1023378
TI  - [Peripheral blood neutrophil reaction to hepatic antigens in patients with
      chronic diseases of the liver].

PMID- 1023379
TI  - [Pathogenesis underlying disturbances in urodynamics of the upper urinary tract
      in pregnancy].

PMID- 1023380
TI  - [Diagnosis of renal hypertension].

PMID- 1023381
TI  - [Treatment of hereditary nephritis in children].

PMID- 1023382
TI  - [Features specific for clinical evolution and treatment of chronic pyelonephritis
      in children with vesico-ureteral reflux and infravesical obstruction].

PMID- 1023383
TI  - [Secondary nonspecific pyelonephritis in patients with renal tuberculosis
      (according to the data of a morphologic and bacteriologic study)].

PMID- 1023384
TI  - [Treatment of patients with coralloid nephrolithiasis complicated by chronic
      renal insufficiency].

PMID- 1023385
TI  - [Deranged function of the upper urinary tract in chronic pyelonephritis].

PMID- 1023386
TI  - [Acute purulent pyelonephritis and its complications].

PMID- 1023387
TI  - [Organ-sparing operations in hydronephrosis complicated by acute pyelonephritis].

PMID- 1023388
TI  - [Restoration of distal ureteral segments].

PMID- 1023389
TI  - [Classification and treatment of chronic prostatitis].

PMID- 1023390
TI  - [Chronic renal incompetence in pyelonephritis].

PMID- 1023391
TI  - [Several features of the course of chronic renal insufficiency in urological
      diseases].

PMID- 1023392
TI  - [Prognosis in urological patients with chronic renal insufficiency].

PMID- 1023393
TI  - [Treatment of pneumonias in acute respiratory diseases of diverse etiology].

PMID- 1023394
TI  - [Splenin treatment of vasomotor and allergic rhinitis in children].

PMID- 1023395
TI  - [Value of cordaron effect - a new coronaroactive agent].

PMID- 1023396
TI  - [Vascular lesions of the liver and possibility of their diagnosis].

PMID- 1023397
TI  - [Experience with carbidine used for treatment of patients with chronic
      alcoholism].

PMID- 1023398
TI  - [Tasks of further improvement of medical service extended to workers].

PMID- 1023399
TI  - [Epidemiological study of allergic diseases and organization of allergological
      service in the USSR].

PMID- 1023400
TI  - [Rehabilitation of patients with bronchial asthma with combined action of health
      resort factors and specific hyposensitization].

PMID- 1023401
TI  - [Immunological shifts in patients with atopical dermatitis].

PMID- 1023402
TI  - [Detection of drug sensitization using the leukocytolysis test].

PMID- 1023403
TI  - [Gluten enteropathy].

PMID- 1023404
TI  - [Influence of Trichuris trichiura and anthelminthic drugs on bacterial flora of
      the intestines in patients with trichocephaliasis].

PMID- 1023405
TI  - [Prolonged course of pneumonias].

PMID- 1023406
TI  - [Cytological characteristics of hamartoma of the lung].

PMID- 1023407
TI  - [Primary generalized amyloidosis].

PMID- 1023408
TI  - [Determination of antibodies to DNA using radioimmunological methods and passive
      hemagglutination reaction in patients with systemic diseases of the connective
      tissue].

PMID- 1023409
TI  - [Further prospects for the development of specific diagnosis and therapy of
      allergic diseases].

PMID- 1023410
TI  - [Basal levels of immunoreactive insulin, somatotropic hormone, glucose and blood
      lipids in patients with coranary atherosclerosis].

PMID- 1023411
TI  - [Serotonin metabolism and reactivity of microvessels in hypertensive diseases].

PMID- 1023412
TI  - [Immunohistochemical study of vessels in hypoplastic anemia].

PMID- 1023414
TI  - [Successes, difficulties, and some errors in drug therapy of internal diseases].

PMID- 1023413
TI  - [Immunoglobulin E in patients with diabetes mellitus and its clinical
      significance].

PMID- 1023415
TI  - [Psychogenic pseudorheumatic carditis].

PMID- 1023416
TI  - [Essence and nomenclature of chronic hepatitis].

PMID- 1023417
TI  - [Features peculiar to diverse strains of Neisseria perflava in the pathogenesis
      of infectious asthma].

PMID- 1023418
TI  - [Current aspects of the classification of bronchial asthma].

PMID- 1023419
TI  - [Early stage of rheumatoid arthritis with long-term differentiated treatment].

PMID- 1023420
TI  - [Immunocompetence of lymphocytes in viral hepatitis and chronic diseases of the
      liver].

PMID- 1023421
TI  - [Indices of cellular immunity in acute dysentery].

PMID- 1023422
TI  - [Forms of allergic lesions of the gastrointestinal tract in early stage of
      opisthorchiasis].

PMID- 1023423
TI  - [Non-occupational pollen and bacterial allergy in patients with eczema and
      neurodermatitis and their specific desensitization].

PMID- 1023424
TI  - Born to be poor: birthplace and number of brothers and sisters as factors in
      adult poverty.
AB  - Household heads who grew up as members of large families and/or as natives of
      small towns or rural areas tend to have less education and are more likely to be
      poor than those coming from small families and/or large cities. Data to support
      these conclusions have been drawn from two independent sources--a special Social
      Security Administration supplement to the April 1968 Current Population Survey
      and findings from the Retirement History Study conducted by the Social Security
      Administration.

PMID- 1023425
TI  - Foreign health programs: changes in population covered.

PMID- 1023426
TI  - Self-employment income at low earnings levels.
AB  - If self-employment were much more prevalent at moderate and high earnings levels
      than at low levels and if the incidence of both the employee and employer taxes
      on wages is on the employee, then the social security tax structure would be
      regressive relative to taxable earnings. Analysis shows, however, that this is
      the case only in a very limited sense. For 1970, 6.5 percent of taxable earnings
      derives from self-employment. At least 6.3 percent of taxable earnings consists
      of self-employment income in each observed interval from $400 to $3,600. The
      proportion declines slightly with rising earnings until near the taxable maximum,
      when it begins to rise. If the average tax rate on earnings up to the maximum
      were tabulated by earnings both below and above the maximum, it appears very
      likely that mild regressivity would be shown beyond the taxable maximum, but of
      not more than a few tenths of a percent.

PMID- 1023427
TI  - Health benefits for laidoff workers.

PMID- 1023428
TI  - Social security in the coming decade: questions for a mature system.

PMID- 1023429
TI  - New retirement options in Sweden.

PMID- 1023430
TI  - SSI payments in metropolitan areas.

PMID- 1023431
TI  - Hospital organization: effectiveness of patient care.

PMID- 1023432
TI  - Women's worklives and future social security benefits.
AB  - More women will earn social security benefits in their own right in the next 30
      years than do so at present; their benefits will not necessarily rise in relation
      to men's benefits. For this to occur, the ratio of women's earnings to men's
      would have to rise markedly or young women would have to work most of their
      lives. The earnings ratio has stayed nearly constant, for 25 years at least. In
      this article, worklives of younger women are estimated from their own early
      experience plus the completed careers of women now retired. Though their total
      labor-force activity before retirement age will be greater than that of these
      older women, the increase will not be sufficient to compensate for the
      lengthening benefit-computation period. Benefits earned on their own records
      therefore will not supplant dependent and survivor benefits.

PMID- 1023433
TI  - Demographic characteristics of disability applicants: relationship to allowances.
AB  - This article highlights some of the causes underlying differences in disability
      allowances by sex and race. Among the causes are differences in labor-force
      patterns, the educational background, and the age distributions of the insured
      and applicant populations. More than half of the differences between the black
      and white applicants in the proportion of claims allowed is explained by
      differences in their age distributions. The lower proportion of claims allowed
      for black applicants may reflect the greater tendency fo the black insured
      population to apply for disability insurance benefits.

PMID- 1023434
TI  - Social security funding practices in selected countries.

PMID- 1023435
TI  - Private pension plans, 1950-74.
AB  - During the past quarter century, private pension plans have enjoyed a healthy
      growth. Although the rate of growth has slackened somewhat during recent years,
      the private pension movement is now a major contributor to the income maintenance
      needs of the American worker during retirement. The passage of pension reform
      legislation in 1974 offers an appropriate milestone year for measuring the
      current status of pension plans and the progress that has been made to date.

PMID- 1023436
TI  - Administrative costs for social security programs in selected countries.

PMID- 1023437
TI  - [Use of counter-immunoelectrophoresis for detection of anti-cholera antibodies].

PMID- 1023438
TI  - [Role of local factors of immunity with regard to cholera infection. I.
      Localization and multiplication of vibrios in ligated small intestine loops of
      non-immunized rabbits and newborn animals].

PMID- 1023439
TI  - [Role of local factors of immunity with regard to cholera infection. II.
      Obtaining immune milk by hyperimmunizing cattle with cholera antigen].

PMID- 1023440
TI  - [Role of local factors of immunity with regard to cholera infection. III.
      Immunologic characteristics of the milk of goats immunized with cholera antigen].

PMID- 1023441
TI  - [Use of a pulmonary model for determining the protective properties of anti
      cholera antibodies. I. Features of the infection process in the lungs of white
      mice following intranasal inoculation with cholera vibrios].

PMID- 1023442
TI  - [Use of a pulmonary model for determining the protective properties of anti
      cholera antibodies. II. Experience in studying the protective properties of the
      serum and milk of immunized animals].

PMID- 1023443
TI  - [Results of comparative assessment of several methods of detecting anti-cholera
      antibodies in retrospective serologic studies].

PMID- 1023444
TI  - [Measurement of the concentration of immunoglobulins G, M and A in the serum of
      healthy subjects in international units].

PMID- 1023445
TI  - [Improvement in the method of obtaining monospecific sera to soluble antigens].

PMID- 1023446
TI  - [Secretory component. II. Isolation and purification of free secretory
      component].

PMID- 1023447
TI  - [Secretory component. III. Determination in biological substrates].

PMID- 1023448
TI  - [Modifications simplifying the method of isolating secretory immunoglobulin A].

PMID- 1023449
TI  - [Detection of immunoglobulins and antibodies to enteropathogenic bacteria in the
      contents of the descending portion of the large intestine of healthy subjects,
      patients with dysentery and other acute intestinal diseases. I. Immunoglobulin
      determination].

PMID- 1023450
TI  - [Detection of immunoglobulins and antibodies to enteropathogenic bacteria in the
      contents of the descending portion of the large intestine of healthy subjects,
      patients with dysentery and other acute intestinal diseases. II. Antibody
      determination].

PMID- 1023451
TI  - The health educator as a suicidologist.

PMID- 1023452
TI  - Worker and caller variety in three crisis centers.
AB  - Worker and caller behaviors are studied and compared in an available sample of
      100 suicidal calls to three crisis intervention centers. Caller-Worker
      Interaction Program results were compared among the three centers. Worker and
      caller differences across centers were significant in 32 of 41 categories (p less
      than .05); using four discriminant functions, 2 of 18 hit percentages exceeded p
      less than .01. The verbal behaviors of workers and callers at the three centers
      are substantially different, leading to the conclusion that crisis intervention
      is dissimilarly practiced between centers but similar within them.

PMID- 1023453
TI  - Suicide survivors: psychotherapeutic implications of egocide.
AB  - Interviews with seven of ten known survivors of jumps from the Golden Gate Bridge
      and San Francisco-Oakland Bay Bridge revealed that all of them experienced
      transcendence and spiritual rebirth phenomena. The psychotherapeutic implications
      of these findings lie in helping depressed and suicidal individuals confront
      death in a symbolic and meaningful way. The issue is one of "egocide" (symbolic
      suicide) and aiding individuals in the rebirth process. In this way actual
      suicides can be prevented. When individuals experience partial "deaths" (like
      loss, failure, rejection, depression, suicidal states, or negative parts of their
      egos), there is opportunity for "rebirth" (positive transformation, creative
      change, growth, and significant spiritual reawakening). The therapeutic task is
      to help individuals differentiate between "ego death" and total death and to
      discover through the creative process of psychotherapy that overt suicide need
      not be a solution.

PMID- 1023454
TI  - Suicide and blacks: a conceptual framework.
AB  - Suicide among black Americans has risen sharply in this decade. The suicide
      pattern differs from that of white Americans in that black suicide is mainly a
      youth phenomenon and the rates between black females and black males are
      relatively equal. The lack of research into these phenomena is highlighted along
      with an exploration of current explanations. A specific conceptual framework is
      proposed that includes extragroup pressure, intragroup pressure, and value
      orientation. The framework is extended into the area of mental health planning,
      as well as behavioral science practice.

PMID- 1023455
TI  - Suicide prevention for high-risk persons who refuse treatment.
AB  - A program was developed to exert a suicide prevention influence on high-risk
      persons who decline to enter the health care system. There were 3,006 patients
      admitted to a psychiatric in-patient service because of a depressive or suicidal
      state who were contacted to determine if the post-discharge plan was followed.
      Half of those who refused their treatment program were contacted by telephone or
      letter on a set schedule. The contact was limited to expressing interest in the
      person's well-being. Mortality in the contact group was compared with the no
      contact subjects and with the subjects who had accepted treatment, after 1, 2, 3,
      and 4 years. Suicidal deaths were found to diverge progressively in the three
      groups, the treatment subjects showing the highest rates, the no-contact group
      coming next, and the contact subjects showing the lowest. The observed divergence
      between the contact and no-contact groups provides tentative evidence that a high
      risk population for suicide can be identified and that a system-atic approach to
      reducing that risk can be applied.

PMID- 1023456
TI  - Understanding life and death from a dialectical perspecitve.

PMID- 1023457
TI  - What trustees should know--and do--about ERISA.

PMID- 1023458
TI  - Why corporate planning should get top billing.

PMID- 1023459
TI  - The statement of mission: essential ingredient in planning.

PMID- 1023460
TI  - Think the plan before you write it.

PMID- 1023461
TI  - [Recent advances in rabies and results of rabies vaccination in Turkey during the
      last 6 years (1970-1975)].

PMID- 1023462
TI  - [Potency studies of sample rabies vaccine, inactivated by beta-propiolactone].

PMID- 1023463
TI  - [Analytic separation of amino acid perfusions].

PMID- 1023464
TI  - [Differentiation of rifamycin SV Na and rifampicin].

PMID- 1023465
TI  - [Comparison of thiabendazole and mebendazole in the treatment of ascariasis and
      enterobiasis].

PMID- 1023466
TI  - [Comparison of tinidazole and nitrimidazine in the treatment of giardiasis].

PMID- 1023467
TI  - Electrophysiological analyses of motoneuron properties in dystrophic mice.

PMID- 1023468
TI  - Blind studies on the effect of amyotrophic lateral sclerosis sera on motor
      neurons in vitro.

PMID- 1023469
TI  - Immunogenetics and amyotrophic lateral sclerosis.
AB  - Immunological capability is to a substantial extent genetically determined.
      Because genetic linkage exists between histocompatibility gene loci and certain
      immune response gene loci, histocompatibility specificities can serve as
      indicators for the presence of particular inherited immunological traits. In man,
      certain HLA antigens seem to be associated with immunogenetic traits which result
      in altered susceptibility to disease with known or suspected viral or autoimmune
      etiologies. We have found an association between HLA-A3 and "classic" cases of
      ALS. The A3 antigen was present in 49% of these cases, but not in the more
      chronic or benign form of the disease. Five out of six "benign" cases carried HLA
      B12, suggesting perhaps the presence of a trait conferring resistance to the
      disease. Epidemiological surveys provide evidence both for and against a
      correlation between the incidence of ALS and that of HLA-A3 in various population
      groups. Because of the multiplicity of immune response genes, susceptibility or
      resistance to ALS in different populations may depend on different immune
      response genes. The association of a disease with selected HLA antigens or
      phenotypes might be suggestive of a viral-allergic etiology. Evidence that bears
      on this hypothesis has been reviewed.

PMID- 1023470
TI  - Theiler's virus-induced central nervous system disease in mice.
AB  - Theiler's viruses, which are common enteric pathogenes of mice, produce an
      unusual buphasic disease in the natural host following IC inoculation. There is
      an early phase of virus growth in CNS gray matter resulting in motor neuron
      degeneration and microglial proliferation. Since the spinal cord is the principal
      site of involvement, infected animals develop flaccid limb paralysis (early
      disease). Immunosuppression of the host during the early phase of infection
      augments virus growth and pathological lesions in gray matter, suggesting that TV
      causes a cytocidal infection of neurons. More importantly, surviving mice have
      persistent infection and pathological change limited to the spinal cord. There is
      marked mononuclear cell infiltration in the leptomeninges and white matter and
      concomitant primary demyelination. These changes are associated  with a
      distinctive late-developing neurological disorder characterized by general
      inactivity, slowed movement, poor righting ability, and stimulus-sensitive
      extensor spasms. It appears that there are differences in host susceptibility to
      the development of late disease with the SJL/J inbred strain of mouse regularly
      showing the most severe clinical manifestations. Both humoral and cell-mediated
      immunity to TV antigen are delayed, reaching a maximum after 2 months; hence,
      this temporal sequence of the immune response is atypical  of acute virus
      infections. Certain features of the late disease process favor an immune-mediated
      mechanism for demyelination, and this possibility is currently under
      investigation. The cells chronically supporting virus replication and the
      mechanisms of persistent infection remain to be elucidated.

PMID- 1023471
TI  - [Isolation and identification of zearalenone].

PMID- 1023472
TI  - [Analysis of phthalophos in pathologic material and feed].

PMID- 1023473
TI  - [Determination of immunoglobulin levels in newborn animals].

PMID- 1023474
TI  - [Methods of demonstrating salmonellae in feed].

PMID- 1023475
TI  - [Large calf pens and animal health].

PMID- 1023476
TI  - [Let's increases the effectivensess of veterinary supervision].

PMID- 1023477
TI  - [Veterinary Service of Kiev: proceedings and responsibilities].

PMID- 1023478
TI  - [Gastric juice--an effective drug].

PMID- 1023479
TI  - [Increasing the effectiveness of scientific research].

PMID- 1023480
TI  - [Resistance of the bodies of calves using different housing technology].

PMID- 1023481
TI  - [Rasing calves in changeable ward dispensaries].

PMID- 1023482
TI  - [Disinfection barriers on stock farms].

PMID- 1023483
TI  - [Immunity in horses with natural and experimental trichophytosis].

PMID- 1023485
TI  - [Cattle leukoses].

PMID- 1023484
TI  - [Effect of several preparations on the immunologic reactivity of nutrias].

PMID- 1023486
TI  - [Reproduction of cattle leukoses in calves].

PMID- 1023487
TI  - [Lymphogranulomatosis in cattle].

PMID- 1023488
TI  - [Control of the routes of transmission of swine plague virus].

PMID- 1023489
TI  - [Epizootology of turkey pasteurellosis and measures for control].

PMID- 1023490
TI  - [Effectiveness of drug in avian respiratory mycoplasmosis].

PMID- 1023491
TI  - [Experience with prevention of chicken influenza with amantadine].

PMID- 1023492
TI  - [Basis for using drug in fish].

PMID- 1023493
TI  - [Diagnosis of toxoplasmosis].

PMID- 1023494
TI  - [Khimotsid for treatment and prevention of toxoplasmosis].

PMID- 1023495
TI  - [Cattle anaplasmosis in Siberia].

PMID- 1023496
TI  - [Ultrastructure of Eimeria kotlani].

PMID- 1023497
TI  - [Novocaine for follicular ovarian cysts in cattle].

PMID- 1023498
TI  - [Treatment of bulls with vibriosis].

PMID- 1023499
TI  - [Manifestations of sexual function in remounted pigs].

PMID- 1023500
TI  - [Reproductive disorders in male breeding pigs].

PMID- 1023501
TI  - [Prevention of latent mastitis is cows].

PMID- 1023502
TI  - [Prevention and treatment of alimentary osteodystrophy in cows].

PMID- 1023503
TI  - [Prevention of calf diseases with propiovit].

PMID- 1023504
TI  - [Bronchopneumonia in young pigs].

PMID- 1023505
TI  - [Improved immobilization stand].

PMID- 1023506
TI  - [Effect of ATP on carbohydrate metabolism].

PMID- 1023507
TI  - Cardiovascular reactivity to noradrenaline and angiotensin in normotensive,
      hypertensive and 6-hydroxydopamine treated rats.
AB  - Blood pressure responses to intravenous noradrenaline and angiotensin in the
      pithed rat preparations from normotensive, chronically hypertensive and 6
      hydroxydopamine (6-OHDA) treated groups were found to follow different patterns.
      6-OHDA treated rats were very sensitive to the effects of the two pressor agents
      and repeated administration of the two drugs invariably led to cardiovascular
      collapse.

PMID- 1023508
TI  - [Surgical aspects of genital disinfection in genitals a Cotonov].

PMID- 1023509
TI  - Clinical trial of pivampicillin hydrochloride (alphacillin) in gonorrhoea
      [proceedings].

PMID- 1023510
TI  - Medical treatment of late complications of Lymphogranuloma venereum
      [proceedings].

PMID- 1023511
TI  - A study of indigenous plants with laxative activity [proceedings].

PMID- 1023512
TI  - Some pharmacological effects of cow's urine concoction in experimental animals
      [proceedings].

PMID- 1023513
TI  - Pharmacological studies on the isolated taenia coli from the horse [proceedings].

PMID- 1023514
TI  - The pharmacology of the alimentary system of the rainbow lizard, Agama agama
      [proceedings].

PMID- 1023515
TI  - Dopaminoceptor agents and electroshock [proceedings].

PMID- 1023516
TI  - Anti-convulsant effects of 2-benzylidene aminooxypropionic acid in young chicks
      [proceedings].

PMID- 1023517
TI  - Anaphylatoxin(AT-induced release of rabbit aorta contracting substance (RCS) in
      isolated perfused guinea-pig lungs [proceedings].

PMID- 1023518
TI  - Chloroquine induced pruritus-immunoglobulin level [proceedings].

PMID- 1023519
TI  - The action of phlorizin on the handling of glucose sodium and potassium by rat
      kidney [proceedings].

PMID- 1023520
TI  - Potentiation of pentobarbitone sleeping time by chloroquine in the rat
      [proceedings].

PMID- 1023521
TI  - Preliminary report on the pharmacology of i-ethyl-B-carboline [proceedings].

PMID- 1023522
TI  - Effect of chloroquine on isolated guinea-pig atria [proceedings].

PMID- 1023523
TI  - [The place of accidental intoxication in pediatric tropical pathology
      (proceedings)].

PMID- 1023525
TI  - [Intoxication by metoclopramide (proceedings)].

PMID- 1023524
TI  - The oxytocic effects of an extract from Sida veronififolia on the non-pregnant
      and the pregnant uterus [proceedings].

PMID- 1023526
TI  - Effects of reserpine on the responses of the isolated rat fundus strip to
      catecholamines and specific adrenoceptor antagonists.
AB  - The effects of reserpine on the sensitivity to catecholamines and adrenoceptor
      antagonists propranolol and azapetine were studied on the fundus strips of the
      rat. The results obtained in this study would support the view that reserpine may
      increase the sensitivity of beta receptor to isoprenaline and adrenaline by the
      mechanism which may be independent of the uptake of catecholamines in the
      sympathetic nervous system.

PMID- 1023527
TI  - [Results of the systematic control of tuberculosis in the People's Republic of
      Poland according to the development of the epidemiological data till 1975
      (author's transl)].
AB  - After the second World War a marked improvement of the epidemiological situation
      in the field of tuberculosis has been achieved in Poland. In 1952 the incidence
      of tuberculosis amounted to 490 per 1000 000 of the population; the prevalence to
      1400. The mortality rate was 105.8 in 1950. In 1974 the incidence rate has been
      reduced to 81.4 (among them 49.4 excretors of tubercle bacilli), the prevalence
      rate was only 248.9 (among them 78.3 with excretion of tubercle bacilli and 11.7
      with chronic tuberculosis--persons excreting tubercle bacilli for more than 2
      years). The mortality rate from tuberculosis amounted to 13.8 at this time. The
      most sensible reduction of all indices was found among children 0-14 years old.
      Tuberculosis in Poland is still a problem of medico-social importance in adults
      and before all in old people, being that part of the population in past times
      only in a low degree vaccinated or revaccinated and in a higher degree exposed to
      severe infections with tubercle bacilli. The comprehensive complex programme of
      tuberculosis control passed by the Sejm of the Polish People's Republic, includes
      three approaches since 1960: the epidemiological, the integrating and the
      phthisiopneumological direction. Prerequisites for the scheduled realisation of
      the programme are the case-finding as early as possible, the quick and correct
      diagnosis and the immediate onset of a specific treatment, further on the
      dispensary care of all contacts of the patient (his surroundings) and optimal
      prophylactic measures against tuberculosis.

PMID- 1023528
TI  - [Detection of healthy carriers of lesions and measures for prevention of
      tuberculous disease in this group in the Esthonian Socialist Soviet Republic
      (ESSR) (AUTHOR'S TRANSL)].
AB  - Tuberculosis morbidity has been markedly reduced in the Esthonian SSR. In
      children and yough tuberculosis is no more a problem. Among the new cases of
      adults formerly diseases or with inactive lesions in the lungs amount to 44,5% of
      the incidence. In the Esthonian SSR all persons with any lesions in the lungs are
      registered in an individual record index. They all are now supervised in
      intervals of a year and less. Another aggravating conditions exist in 13,6% of
      these persons. Chemotherapy or chemoprophylaxis is done in this group. A marked
      reduction of morbidity has been attained in this way.

PMID- 1023529
TI  - [High incidence of lung cancer in persons with chronic professional exposure to
      pesticides in agriculture (author's transl)].
AB  - In an epidemiological study in the Neubrandenburg district among 316 long-term
      exposed pesticide workers the incidence of tumors was investigated. There were 30
      cases of tumors, of which 11 were lung cancers. The incidence of lung cancers was
      in contrast to age-specific population twenty times higher. The average exposure
      against pesticides amounted to 14.1 +/- 4.7 (6-23) years, the latency period
      between exposition start and tumor manifestation to 17.9 +/- 6.0 (6-23) years.
      The exposure occurred mainly to the following agents: herbicides, such as
      derivatives of phenoxyacetic acid (2,4 D and MCPA); insecticides, such as
      chlorinated hydrocarbons (DDT, HCH and Toxaphen), organic phosphorus compounds
      (Parathion) and organic nitro derivatives (DNOC) as well as fungicides, such as
      copper containing and organic synthetic agents. Between 1950 and 1956 some
      pesticide workers were also exposed to arsenic containing agents. As the workers
      were exposed to various chemical compounds simultaneously or alternatively, no
      carcinogenic effect can be determined by specific individual pesticides. The
      investigations are discussed in detail on the today knowledge about cancer
      hazards associated with exposure to pesticides, and respective conclusions are
      drawn for preventive measures.

PMID- 1023530
TI  - [Massive endobronchial hemorrhage during bronchological examination-successful
      treatment by temporary half-side blocking by means of a Carlens-tube (author's
      transl)].
AB  - During a bronchological examination a massive endobronchial hemorrhage from the
      left bronchial system occurred in a 48 year old woman suffering from pneumonia of
      the right 6th segment of the lung. Successful treatment by use of a Carlens-tube
      with half-side blocking. Later on, the left lower lobe was removed by operation.
      Pathological findings showed multiple lung-infarctions. The possibilities of
      treatment are discussed in the case of endobronchial hemorrhage in the course of
      bronchological examinations.

PMID- 1023531
TI  - [Hemothorax--a life-threatening complications of spontaneous pneumothorax
      (author's transl)].
AB  - A 23-year old male with an spontaneous hemopneumothorax and in the state of
      severe shock was admitted to our hospital. The etiology, incidence and
      therapeutic measures are discussed. It is recommended that patients with
      spontaneous hemopneumothorax after securing the diagnosis by radiography and
      puncture biopsy have to be admitted immediately in a thoracic surgery clinic. An
      early thoracotomy is favourable.

PMID- 1023532
TI  - [Diagnosis, clinic and therapy of bronchial adenomas (author's transl)].
AB  - Report on diagnosis, clinic and therapy of 77 cases with bronchial adenomas.
      These semimalign tumours of the respiratory tract amounted to 1.5 per cent of all
      lung tumours admitted to our clinic within 21 years and were growing
      predominantly in the central parts of the respiratory tract. Resection therapy is
      the therapy of choice. Although potential malign, the bronchial adenomas differ
      markedly from bronchial carcinomas in relation to prognosis and mortality.

PMID- 1023533
TI  - [Evaluation of the monocyte test for diagnosis of allergic asthma bronchiale
      (author's transl)].
AB  - We investigated, if in routine work the relative simple monocyte test can improve
      the diagnostic yield of allergic asthma bronchiale in comparison with the
      inhalative allergen test. In 600 patients differential counts in peripheral blood
      were performed before, 30, and 60 minutes after inhalation of the allergen and
      the increase of monocytes was evaluated. Monocyte test and inhalative allergen
      test proved to be concordant in 67%, this value was statistically significant,
      but control trials failed in 11%. Therefore, the monocyte test fails to be of
      diagnostic value in allergic asthma, it does not increase additionally the
      diagnostic yield as a routine method.

PMID- 1023534
TI  - [Report of the XXIII. Conference of International Union against Tuberculosis,
      Mexico-City, September 1975 (author's transl)].

PMID- 1023535
TI  - [Report of the XI. National Congress of Tuberculosis and Lung Diseases in
      Bucharest from 9. to 10. 10. 1975 (authors's transl)].

PMID- 1023536
TI  - [Animal experiments on the etiology and histogenesis of colonic carcinoma].
AB  - The influence of nutrition upon the etiology and histogenesis of
      dimethylhydrazine induced carcinomas of the colon was studied in rats. A double
      way Anus praeter was made in one-half of the animals (393/823). Histological and
      statistical analysis of more than 7000 organ preparations yielded the following
      results: (1) The intestinal contents has effects on localization, latency, and
      frequency of the colonic tumour. (2) When maintained on a protein-rich diet, rats
      with Anus praeter developed intestinal carcinomas more frequently and earlier
      than the corresponding controls, or with other dietary regimens under otherwise
      equal conditions. (3) In rats with Anus praeter the inflammatory stimulus on the
      ectopied mucosa exerted a stronger co-carcinogenic effect than the intestinal
      contents. (4) The genetic predisposition of the organ plays an important role in
      tumorigenesis. (5) In no case did intestinal carcinomas develop de novo, that is,
      from the unaltered, intact intestinal mucosa. (6) DMH induced carcinomas of the
      colon was solitary in 46% of the cases, and multiple in 54%. Histological
      differences within the same carcinoma (10% of the cases) are also indicative of a
      frequent, multicentric genesis of colonic carcinomas. (7) The significance of
      submucous, lymphocytic plaques for the immunological defense system requires
      further experimental clarification. (8) Polyps of the colon are a potential, but
      no necessary, intermediate from of cancerization.

PMID- 1023537
TI  - [Enzymatic microanalytical methods for energy-rich phosphates, glucose and
      glucose metabolites in biopsy material from muscle in man. 1. Enzymatic
      determination of ATP, ADP, AMP, CP and Cretine].

PMID- 1023538
TI  - [Apparatus for the fumigation of foam-cell suspensions, measurement of oxygen
      partial pressure and transfer of suspension for irradiation purposes].

PMID- 1023539
TI  - [Thermography using liquid crystals. 1. Principles of methodology for the
      recording and evaluation of thermographic pictures].

PMID- 1023540
TI  - [Thermography using liquid crystals. 2. Problems of application in medical
      practice].

PMID- 1023541
TI  - [Cutting device for rapid heat inactivation of tissues with following ATP
      determination].

PMID- 1023542
TI  - [Chorella as indicator cell for the detection of ligand receptor relationships in
      tissue culture cells].

PMID- 1023543
TI  - [Direct method for the microbiological determination of total urinary
      desoxyribosides].

PMID- 1023544
TI  - [Experiences with combined optical crystal and x-ray diffractometric analysis of
      uninary calculi].

PMID- 1023545
TI  - [Size measurements of macrophages using the electronic evaluating device
      Densitron].

PMID- 1023546
TI  - [Incubation chamber for the treatment of serial sections].

PMID- 1023547
TI  - [Routine use of an adapted EK-Aut for the determination of transaminases using
      the UV test at 37 degrees C].

PMID- 1023548
TI  - [Occlusion of the ductus arteriosus in the rabbit. A light and electron
      microscopic study].
AB  - The development of changes appearing with the closure of ductus arteriosus was
      followed in mature rabbit foetuses with the help of light and electron
      microscopy. In the foetuses, in which there was no spontaneous respiration of
      atmospheric air before fixation the ductus remained opened. In smooth muscle
      cells of the media there were enlarged cisternae of the endoplasmic reticulum
      being partially decayed. The foetuses that respired for about one minute had the
      ductus contracted to various degree and the endothelial cells were expelled into
      the lumen. In the foetuses respiring for 10 minutes the ductus were more
      contracted. The endothelium was considerably waved and the agglomeration of
      smooth muscle cells appeared. In the endothelial and musclar cells the
      endoplasmic reticulum was richer, and in a lot of places considerably disturbed.
      The ductus of foetuses respiring for 15 minutes had the lumen completely closed.
      The smooth muscle cells had a significantly changed their internal structure. The
      possibility of the direct transformation of the endoplasmic reticulum of the
      smooth muscular cells into inclusion bodies during the ductus arteriosus closure
      is discussed.

PMID- 1023549
TI  - Histochemical study of distribution of esterases in the pharyngeal bulb of
      earthworms.
AB  - The esterases are studied histochemically in the pharyngeal bulb of local
      earthworms using tweens, naphthols and indoxyl substrates. Lipase and esterases
      are located mainly in the pharyngeal epithelial cells and chromophill cells. No
      activity is seen in the nonchromophill cells. The connective tissue and musculo
      vascular tissue contain some esterases activity. Possible role of the esterases
      in the cellular elements of pharynx has been discussed.

PMID- 1023550
TI  - Structure of synapes in the supraoesophageal ganglion of the water beetle
      (Dytiscus marginalis).
AB  - 1. Light- and electron microscopic investigations prove that synapses, without
      any exception, are confined to the neuropil. 2. Under the light-microscope,
      synapses display the shape of terminal boutons at the ends of the nerve fibres;
      in some cases they appear as smaller or larger plates. Electron microscopic
      investigations suggest that also varicosities of nerve fibres can be regarded as
      synapses, though these might have possible arisen from axoplasmatic peristalsis.
      3. Electron microscopically the overwhelming majority of the synapses are
      axodendritic contacts; axo-axonic contacts occur less often. 4. The generally
      accepted characteristics of synapses are defective. Membrane thickenings and
      intersynaptic spaces are missing. Accordingly, synapses in the supraoesophageal
      ganglion of the water beetle differ markedly from those described in Vertebrates.
      5. Synaptic vesicles sometimes fill the axoplasm of the nerve fibre completely.
      In other cases, clusters of synaptic vesicles can be seen, on both sides of the
      contact. 6. Synaptic vesicles are mixed with neurosecretory granules. Synaptic
      vesicles may appear also in the dendrites.

PMID- 1023551
TI  - Histochemical mapping of certain enzymes in few fresh water teleosts. I. Acid
      phosphatase.
AB  - A detailed investigation of the distribution pattern of acid phosphatase in the
      different parts of alimentary canal and associated glands of Colisa fasciatus,
      Macrognathus aculeatus, Notopterus notopterus and Nandus nandus has been made.
      Though this enzyme shows its hydrolytic activity in all the parts of the
      digestive system yet its intense activity has been noted in the intestine,
      pyloric caeca, liver and pancreas of all the 4 fishes. Mucosal and submucosal
      layers of all the parts of the alimentary canal are the main seat of localization
      of this enzyme.

PMID- 1023552
TI  - [Histochemical study of the activity of aspartate aminotransferase in the spinal
      cord, the medulla oblongata and the central cerebellar nuclei of several
      vertebrates].
AB  - The aspartate aminotransferase activity (AAT) is reserched into the spinal cord,
      the medulla oblongata and the cerebellar nuclei of the rat, chicken, Lacerta
      lepida and Bufo calamitas. It's proved that the AAT activity shows in many
      locations, that are mainly: 1. In the nerve fibers 2. In the cytoplasmic
      membrane, and in the nuclear membrane of the neurons 3. In all neuronal
      cytoplasm, and 4. In the mitochondria of neurons and choroid plexus cells. The
      results base the idea that there's more than one pool of glutamic acid in
      relation to that AAT. It's suggested that the role that AAT plays is different in
      everyone of the described locations, and may be it's connected with transport
      phenomenons in the membrane, with energetic function on the mitochondria and with
      functions of the nerve impulse transmission in the synapsis. We remark, finally,
      the interest that the enzymatical works can have the time comming to establish
      homologies among similar structures of several animal's nervous system.

PMID- 1023553
TI  - Effects of dactinomycine (actinomycine D) on budless hydra and during its budding
      process.
AB  - The effect of dactinomycine (actinomycine D) is manifested in various ways, which
      depends upon its concentration and animal condition at the time of treatment.
      Dactinomycine is citotoxic in stronger concentations so hydra dies quickly. In
      thinner concentrations it stops the mitotic activity of the cell, but the basic
      metabolic processes continue as before. Interstitial cells differenciate into
      cnidoblasts for some time, the cnid production is not halted, but all of these
      cells disappear as well as zimogen cells which dedifferentiate into gastrodermal
      interstitial and into mucous cells. Such animals live longer but die eventually.
      The effect of dactinomycine is generally milder on animals with a larger cell
      mass, in hydras with the budding tendency where exist such reserves and in those
      hydras in which the budding process has begun. In these a part of mobile
      undamaged zimogen cells can remain. They keep their reproduction ability. These
      animals can survive and keep on growing normally.

PMID- 1023554
TI  - [Light and electron microscopic studies of nucleus-like formations of fragmented
      oocytes in rat ovary].
AB  - Oocytes in ovarian atretic follicles now and then show in their cytoplasm
      nucleuslike formations. The appearance of those pseudonuclei in the rat is
      described by light-and electron microscopy. Every pseudonucleus contains one or
      more Feulgen positive particles, and is surrounded by a membrane on its surface.
      The pseudonuclei are formed in the course of degeration of the oocyte during 1.
      und 2. meiotic metaphase from contracted chromosomes, probably with the
      involvement of the mixoplasma.

PMID- 1023555
TI  - Occurrence and frequency of enterochromaffin cells in the intestine of birds.
AB  - The occurrence and frequency of enterochromaffin cells in the intestine of 14
      separate species of birds, the quantitative variations in the several sections of
      the intestine and the quantitative changes in the embryonic and postembryonic
      development of Anas platyhynchos have been investigated by the Protargol-reaction
      of Bodian and the fluorescence method of Falck and Hillarp. Enterochromaffin
      cells are concentrated in the crypts of Lieberkuhn in first line. They have been
      found in all investigated species but in various frequency. The enterochromaffin
      cells exist frequently in herbivorous species, scarcely in carnivorous. The
      number of enterochromaffin cells increase from the duodenum to the colon. The
      enterochromaffin cells appear in the intestine of the duck embryo beginning with
      the 15th day of embryonic life. The number increase related with the age of the
      duckling. The content has been identified as 5-hydroxy-tryptamine by the colour
      of fluorescence and depletion of all enterochromaffin cells following reserpine
      administration.

PMID- 1023556
TI  - Histochemical localization of lipid in the respiratory muscles of a fresh water
      air-breathing siluroid fish, Clarias batrachus (Linn.).
AB  - The histochemical localization of lipids in the respiratory muscles of Clarias
      batrachus (Linn.) has been studied. The muscles innervated by the facialis
      (VIIth) nerve contain more lipid than those innervated by the trigeminal (Vth).
      The muscles directly concerned with the opercular suction pumps (Inferior and
      Superior hyohyoideus, Adductor, Levator and Dilator operculi) have more lipids
      and suggest their sustained role in the maintainance of efficiency of the
      opercular suction pumps. The Retractor tentaculi associated with the movements of
      barbels also have lipid droplets in good quantity.

PMID- 1023557
TI  - [DNA inhibition and development of the pigment epithelium and receptors in rat
      retina].
AB  - In the retina of the guinea pig the outer segments of the receptor cells are
      damaged by cyclophosphamid, but the inner segments and the centriole are not
      altered. The disturbed membranes of the outer segments are incorporated by
      pigment epithelium. The progress of degeneration of outer segments corresponds
      with the increase of the number of Lysosomes in the pigmemt epithelium. The
      structure of mitochondria is disturbed by blocking the DNA. The unaltered
      mitochondria show a normal reaction of succinode hydrogenase.

PMID- 1023558
TI  - [Effect of colchicine and lumicolchicine on the ultrastructure of non-myelinated
      axons in autonomic nerves in cat in vitro].
AB  - The effects of colchicine and lumicolchicine on the ultrastructure of non
      myelinated axons in cat autonomic nerves were studied using in vitro preparations
      of inferior mesenteric ganglion/hypogastric nerves. After 24 hrs of in vitro
      incubation with colchicine added to the medium (10 microng/ml) a significant
      decrease in number of neurotubules per 1 axon was observed. In the presence of a
      solution of alpha-beta and gamma-lumicolchicine (10 microng/ml) severe
      degenerative changes occured in axons and Schwann cells. At a lower dose of
      lumicolchicine (3 microng/ml) these changes were less frequent and the number of
      neurotubules per 1 axon did not differ from that in control nerves.

PMID- 1023559
TI  - The ossification centers in the lower end of tibiotarsus in domestic fowl.
AB  - The morphogenesis of lower end of tibia in chick is studied commonly but the
      process of ossification of the same has received very little attention so far.
      The present study is directed to throw some light on the appearance of
      ossification centers in the lower end of tibiotarsus of chick. The histology of
      lower end of tibiotarsus was studied by procuring developing tibiotarsi from
      chick embryos (20) of 6th day incubation till hatching and 3 post hatched chicks.
      The transparancies of chick embryos at different incubation periods and post
      hatched chicks were prepared by Dawson's Alizarin staining method. Three
      cartilage center (tibial, fibulare and intermedium) appeared in 6...9 days of
      incubation period in the tarsal region. These gradually fused with the lower end
      of tibia. Three ossification centres developed in the lower end of tibiotarsus.
      One for intermedium appeared on 16th day and two fotibial and fibulare on 20th
      day. All these three centres could be located in the transparancies of the chick
      embryos in tarsal region. The present study proves that the three cartilages
      centres maintain their individuality during the ossification process even though
      those fuse completely with the lower end of tibia in chick. The centers for
      tibial and fibulare are similar to epiphyseal centres of mammals in histological
      details.

PMID- 1023560
TI  - [Dynamics of epithelioid cells in juxtaglomerular apparatus].

PMID- 1023561
TI  - [C cells and calcitonin effect in rats (morphological and functional study].

PMID- 1023562
TI  - [Effect of 6-hydroxydopamine on mouse adrenal modulla with simultaneous
      inhibition of catalase with aminotriazole].

PMID- 1023563
TI  - Effect of indoleamine derivates administered at birth on growth and plasma growth
      hormone levels in the rat.

PMID- 1023564
TI  - [Effect of adrenal hormones on development of intestinal epithelium].

PMID- 1023565
TI  - [Sex steroid hormone producing epididymis nodules in rooster].

PMID- 1023566
TI  - [Pituitary control of follicle maturation in farm mink (Mustela vison dom.)].

PMID- 1023567
TI  - [Ultrastructure of capillaries and pericapillary tissue in guinea pig corpora
      lutea].

PMID- 1023568
TI  - [Ultrastructure and junctions of lutein cells during corpus luteum development in
      sheep].

PMID- 1023569
TI  - Effects of hemicastration, testis implantation and administration of testosterone
      propionate on the female embryonic genital tract in various breeds and strains of
      chickens.

PMID- 1023570
TI  - [Ultrastructure of corpuscles of stonnius in Salmo irideus under hypertonic salt
      solution loading].

PMID- 1023571
TI  - [Comparative anatomy of allocortex].

PMID- 1023572
TI  - [Cell density of primate cortex and its significance for phylogeny of connecting
      cells].

PMID- 1023573
TI  - [Pallial development in reptiles].

PMID- 1023574
TI  - [Electronmicroscopical study of course of neuronal axons in cat area 17].

PMID- 1023575
TI  - Olfactory and temporal projections to the amygdala.

PMID- 1023576
TI  - [Difference in course of apical dendrites in "barrel field" and area parietalis
      in mice].

PMID- 1023577
TI  - [Small pigment containing astrocytes in second and third layer of human
      isocortex].

PMID- 1023578
TI  - [Stucture of external glial layer of human isocortex].

PMID- 1023579
TI  - Early prenatal ontogenesis of the neuronal connections in the interhemispheric
      cortex of the human gyrus cinguli.

PMID- 1023580
TI  - [Dendrite differentiation in fascia dentata and hippocampus].

PMID- 1023581
TI  - [Dendrite development in olfactory centers].

PMID- 1023582
TI  - [Origin of astroblasts in neocortex].

PMID- 1023583
TI  - [Morphometrical analysis of development of area striata in Tupaia belangeri].

PMID- 1023584
TI  - [Projection of lateral posterior nucleus - pulvinar complex].

PMID- 1023585
TI  - [Demonstration of single neurons in vitro in ventral surface of medulla
      oblongata].

PMID- 1023586
TI  - [Some observations on the ultrastructure of the amygdala].

PMID- 1023587
TI  - [Influence of psychopharmaceutics on amino acid metabolism of central nervous
      system].

PMID- 1023588
TI  - [Role of glia in glycoportein metabolism of CNS].

PMID- 1023589
TI  - [Cerebellar artery segments].

PMID- 1023590
TI  - [Electronmicroscopical, functional morphological, morphometric analysis of
      anterior pituitary of Xenopus leavis (Anura)].

PMID- 1023591
TI  - [Vascularization of cerebellar dentate nucleus].

PMID- 1023592
TI  - [Segregation of amphibian CNS. Analysis of induction process using combination
      experiments in Ambystoma mexicanum].

PMID- 1023593
TI  - [The myelinated parallel fibers of the cerebellar cortex and their regional
      distribution].

PMID- 1023594
TI  - [Details of myelinization in peripheral nervous system].

PMID- 1023595
TI  - [Autonomic representation in guinea pig thoracic spinal cord].

PMID- 1023596
TI  - [Ultrastructural study on function of monoamine containing cells of rat superior
      cervical ganglion].

PMID- 1023597
TI  - [Effect of disulfiram on rat superior cervical ganglion].

PMID- 1023598
TI  - [Light and electron microscopical study of pressoreceptor fields in carotid sinus
      wall of cat, rabbit and dog].

PMID- 1023599
TI  - [Demonstration of complex endothelial and perivascular system of membrane
      contacts in choroid plexus].

PMID- 1023600
TI  - [Central connections of cat vagus nerve after intracranial vagotomy and
      subsequent lung disorders].

PMID- 1023601
TI  - [Effect of intracellular pigments on emission spectra of biogenic amines.
      Microfluorimetric study on pigment synthesizing cells in human skin].

PMID- 1023602
TI  - [Structural differences between nude mouse skin and human bald skin].

PMID- 1023603
TI  - [Studies on hedgehog infundibulum].

PMID- 1023604
TI  - [Ultrastructure of Ruffini corpuscles (spray-like endings) in knee joint capsule
      of domestic cat].

PMID- 1023605
TI  - [Spatial organization of retinomotor responses in adult and young Haplochromis
      burtoni (Cichlidae, Teleostei)].

PMID- 1023606
TI  - [Biomechanical analysis and explication of corneal curve changes after oculomotor
      muscle surgery].

PMID- 1023607
TI  - [Electronmicroscopical study on spiral ganglion of fetal guinea pig cochlea].

PMID- 1023608
TI  - [Influence of vagus nerve on liver and pancreas function].

PMID- 1023609
TI  - [Quantitative study of supraoptic nucleus].

PMID- 1023610
TI  - [Pineal body and testis: morphological study on effect of light deprivation on
      golden hamster spermatogenesis].

PMID- 1023611
TI  - [Effect of light deprivation on melatonin synthesis and testicular activity in
      golden hamster].

PMID- 1023612
TI  - [Postnatal development of golden hamster epiphysis cerebri].

PMID- 1023613
TI  - [Ultrastructure of rat pineal body after autotransplantation in anterior eye
      chamber].

PMID- 1023614
TI  - [Atypical forms of mammalian pineal body].

PMID- 1023615
TI  - [Seizure mechanism of anesthesia development].

PMID- 1023616
TI  - [Pathogenesis of acute cirulatory disorders following open heart surgery (clinico
      experimental study)].

PMID- 1023617
TI  - [Comparative informativeness of the summary EEG, high-frequency component EEG and
      evoked responses in studying the mechanisms of general anesthesia].

PMID- 1023618
TI  - [Integral assessment of the oxygen regime during the postoperative period].

PMID- 1023619
TI  - [Hemodynamic effects of hexenal, seduxen and morphine in patients with low
      cardiac output].

PMID- 1023620
TI  - [Effect of penthrane anesthesia on hemodynamics in children].

PMID- 1023621
TI  - [Clinico-pharmaceutical features of use of medicinal substances for premedication
      and anesthesia in children].

PMID- 1023622
TI  - [Effect of chemotherapy with cyclophosphane on the myoparalytic effect of
      tubocurarine].

PMID- 1023623
TI  - [Relationship between anesthesia in neurosurgical patients and the osmotic
      condition of blood and cerebrospinal fluid].

PMID- 1023624
TI  - [Dynamics of several hormones in the blood during oncologic surgery under
      neuroleptoanalgesia].

PMID- 1023625
TI  - [Recovery of ambulatory patients after several types of intravensou anesthesia].

PMID- 1023627
TI  - [Puncture catheterization of the superior vena cava through the internal jugular
      vein].

PMID- 1023626
TI  - [Advantages and features of an injection method of artificial pulmonary
      ventilation during bronchoscopy in children].

PMID- 1023628
TI  - [Hematologic characteristics of lichen ruber planus of the buccal mucosa and the
      red border of the lips].

PMID- 1023629
TI  - [Pathogenic mechanism of experimental allergic dermatitis of chemical etiology].

PMID- 1023630
TI  - [Rate of anaerobic glycolysis in the skin and blood of patients with ichthyosis].

PMID- 1023631
TI  - [Differential diagnosis of nail dystrophy of obscure etiology].

PMID- 1023632
TI  - [Cellular and humoral immunity response in patients with mycosis of the feet due
      to Trichophyton rubrum].

PMID- 1023633
TI  - [Mycotic urethritis in men].

PMID- 1023634
TI  - [Approaches to genetic studies in dermatology].

PMID- 1023635
TI  - [Clinical importance of polarographic determination of oxygen in the skin (review
      of the literature)].

PMID- 1023636
TI  - [Disorders of the function of visceral organs and endocrine system in
      ichthyosis].

PMID- 1023637
TI  - [Case of syringoma].

PMID- 1023638
TI  - [4 cases of so-called hysteric pemphigus].

PMID- 1023639
TI  - [Data on histomorphological and histochemical studies on the gastric mucosa in
      patients with chronic lupus erythematosus].

PMID- 1023640
TI  - [Unithiol in treatment of circumscribed forms of scleroderma].

PMID- 1023641
TI  - [Deoxyribonuclease in treatment of recurrent herpes simplex].

PMID- 1023642
TI  - [Decametoxine in dermatological practice].

PMID- 1023643
TI  - [Characteristics of the activity of several enzymes of carbohydrate and protein
      metabolism in patients with eczema and neurodermatitis].

PMID- 1023644
TI  - [Indices of autoimmune response in patients with trichomoniasis].

PMID- 1023645
TI  - [Treatment of viral skin diseases with Soviet-made antiviral drugs].

PMID- 1023646
TI  - [Functional state of mast cells in microbial eczema].

PMID- 1023647
TI  - [Permeability of the epidermis for lead acetate according to fluorescence and
      electron-microscopic studies].

PMID- 1023648
TI  - [Certain urgent problems of treatment of microsporosis of the scalp (according to
      the questionnaire materials of the Donets Regional Scientific Society of
      Dermatovenereologists)].

PMID- 1023649
TI  - [Immunological studies in candidiasis].

PMID- 1023650
TI  - [Pathogenesis of eczema].

PMID- 1023651
TI  - [Various problems of epidemiology and clinical course of psoriasis].

PMID- 1023652
TI  - [Dermatological symptoms in syringomyelia].

PMID- 1023653
TI  - [Topical treatment of skin basalioma with prospidin].

PMID- 1023655
TI  - [Case of benign pigmentary-papillary dystrophy of the skin].

PMID- 1023654
TI  - [Treatment of skin diseases with honey].

PMID- 1023656
TI  - [Unusual course of cutaneous sporotrichosis].

PMID- 1023657
TI  - [Reinfection and superinfection].

PMID- 1023658
TI  - [Vesiculous siphilid].

PMID- 1023659
TI  - [Materials on the clinical course, immunologic reactivity and treatment of
      pyoderma].

PMID- 1023660
TI  - [Treatment of mixed gonorrheal-Trichomonas infection].

PMID- 1023661
TI  - [Remote results of treatment of trichomonas vaginitis].

PMID- 1023662
TI  - [Astheno-vegetative hypoxic syndrome in chronic maxillary sinusitis and that
      combined with ethmoiditis].

PMID- 1023663
TI  - [Electrorentgenography in diagnosis of pathologic conditions of paranasal sinuses
      in patients with allergic sinusopathy].

PMID- 1023664
TI  - [Tomography of frontal sinus diseases].

PMID- 1023665
TI  - [Experimental study of the rule of palatine tonsils in the formation of body's
      adaptive immunity].

PMID- 1023666
TI  - [Study of oxyfluoride narcosis effect on blood coagulation and anticoagulation
      systems during tonsillectomy].

PMID- 1023667
TI  - [State of palatine and nasopharyngeal tonsils in children with
      hypogammaglobulinemia].

PMID- 1023668
TI  - [Combined method of treating metallurgical plant workers suffering from chronic
      tonsillitis].

PMID- 1023669
TI  - [Genesis of experimental otospongiosis].

PMID- 1023670
TI  - [Needle reflex therapy in some otorhinolaryngeal diseases].

PMID- 1023671
TI  - [Incidence of paranasal sinusitis in children].

PMID- 1023672
TI  - [Treatment of non-approximation of vocal folds in singers by means of a method
      causing narrowing of the larynx entrance].

PMID- 1023673
TI  - [Emergency tracheotomy].

PMID- 1023674
TI  - [Peculiarities of otholaryngeal pathology during the Spring season of 1975 in the
      area of Kef Province].

PMID- 1023675
TI  - ["Lost time" and trends of conservative surgery in cancer of the larynx].

PMID- 1023676
TI  - [Inflammation of the paranasal sinuses in miners].

PMID- 1023677
TI  - [Method of treating chronic tonsillitis by lavage of the lacunae].

PMID- 1023678
TI  - [Peculiarities of Highmore's antrum lesions in zygoma fractions].

PMID- 1023679
TI  - [Foreign bodies in the respiratory tract in children].

PMID- 1023680
TI  - [Threshold adaptation by Carhart's method in the study of the hearing function in
      children].

PMID- 1023681
TI  - [Herpes zoster oticus].

PMID- 1023682
TI  - [Case of Osler's disease with massive nasal hemorrhage].

PMID- 1023683
TI  - [Bacterial flora of the nose and the maxillary sinuses during maxillary sinusitis
      and its sensitivity to antibiotics].

PMID- 1023684
TI  - [Ammonium hydroxide burn of nasal, pharyngeal and laryngeal mucous membrane].

PMID- 1023685
TI  - [Stenosal laryngotracheobronchitis complicated by gangrene of both feet, ungual
      hand phalanges and auricles].

PMID- 1023686
TI  - [Voluminous foreign body in the trachea].

PMID- 1023687
TI  - [Tooth as a foreign body in the trachea].

PMID- 1023688
TI  - [Trauma of the carotid artery during electrocautery of palatine tonsils with
      favorable outcome].

PMID- 1023689
TI  - [Diffuse suppuration of cervical cellular areas in a 1-year-old child].

PMID- 1023690
TI  - [Allergic reaction to aqueous solution of furacillin].

PMID- 1023691
TI  - [Long styloid process and neuritis of glossopharyngeal nerve].

PMID- 1023692
TI  - [Device for recording microphone response of animal and human cochlea].

PMID- 1023693
TI  - [Tracheotomic tube for laryngectomized patients].

PMID- 1023694
TI  - Urinary bladder tumours in Zambia.
AB  - The clinical picture of bladder cancer as seen in Zambia is presented. The
      majority of lesions were squamous carcinoma and although all cases were first
      seen at a late stage it was possible to undertake a potentially curative
      operation in 16%. Operation provides excellent palliation and should be
      considered wherever possible.

PMID- 1023695
TI  - Assessment of transvenous right atriography in the diagnosis of pericardial
      effusion.
AB  - From our results, we feel that transvenous right atriography is a reliable
      confirmatory investigation of pericardial effusion. The procedure is simple and
      can be carried out in any hospital. Spurious positive results may arise from
      faulty technique or due to marked pericardial thickenning whilst false negatives
      may be enountered with viscid, inspissated or loculated pericardial effusion.

PMID- 1023696
TI  - Vasopressin-sensitive diabetes insipidus-a case report.
AB  - This is a case report of Vasopressin - Sensitive Diabetes Insipidus in a 5 year
      old Zambian Coloured male child together with a brief review of etiology,
      diagnosis and management of the condition.

PMID- 1023697
TI  - Antenatal care and eclampsia.

PMID- 1023698
TI  - Schistosomiasis and bladder cancer.

PMID- 1023699
TI  - Impact of piped water supply on the incidence of typhoid fever and diarrhoeal
      diseases in Lusaka.
AB  - The effect of piped water supply on the incidence of typhoid fever and diarrhoeal
      diseases in the City of Lusaka is reported. The incidence of typhoid fever and
      diarrhoeal diseases reduced in the City as the piped drinking water was extended
      to the Urban and peri Urban self-help settlements.

PMID- 1023700
TI  - Chronic endometritis. A clinical and histopathological study.
AB  - Chronic endometritis is not an uncommon diagnosis in our biopsy material and we
      believe should be diagnosed more frequently. There seems to be no correlation
      however between clinical symptomalogy and severity of plasma cell infiltration of
      the endometrial stroma as observed histologically. Pelvic inflammatory disease is
      the condition most commonly associated with chronic endometritis. The precise
      etiology of pelvic inflammatory disease is not clear. No clinical cause could be
      found in 37.5% of our cases with histopathological diagnosis of chronic
      endometritis.

PMID- 1023701
TI  - [Tendon-muscle plastic repair in the operative treatment of the sequelae of
      poliomyelitis].

PMID- 1023702
TI  - [Mitochondrial monoamine oxidase in the brain, stomach and liver in experimental
      gastric ulcer and the change in their activity under the influence of quateron].

PMID- 1023703
TI  - [Oxytetracycline penetration, distribution and retention in the body of pregnant
      rabbits and their fetuses].

PMID- 1023704
TI  - [Change in the content of free amino acids in the tissues of the walls of
      arterial vessels under the influence of vasoactive substances].

PMID- 1023705
TI  - [Pentose cycle enzymatic activity in the liver of rats with chronic chloroprene
      toxicosis and the role of vitamin E in this process].

PMID- 1023706
TI  - [Experimental study of the toxicity and antitumor activity of halide derivatives
      of ethyleneimine].

PMID- 1023707
TI  - [Vasoconstrictor properties of the blood and its content of catecholamines in
      obliterating endarteritis of the lower extremities].

PMID- 1023708
TI  - [Disorder of the homeostasis of the blood coagulation system and fibrinolysis in
      chronic tonsillitis with the tonsillocardiac syndrome].

PMID- 1023709
TI  - [Standardization of the load capacity in studying external respiratory function].

PMID- 1023710
TI  - [Absorption and the resorptive toxic factors of some chemical compounds in skin
      lesions by aggressive substances].

PMID- 1023711
TI  - [Carotid angiography in the diagnosis of supratentorial traumatic hematomas with
      acute and subacute courses and the phenomenon of "pseudocarotothrombosis"].

PMID- 1023713
TI  - [To find the cheese on the toast].

PMID- 1023712
TI  - [Blood coagulation system indices depending on the type of anesthesia in
      orthopedic injury operations].

PMID- 1023714
TI  - [Plasma chemistry and the possibilites for its application to the desulphuration
      of petroleum].

PMID- 1023715
TI  - [Group effect on learning in fish (Rasbora trilineata)].

PMID- 1023716
TI  - [Experimental studies on the anti-inflammatory action of penicillamines].

PMID- 1023717
TI  - [Metabolic disturbances in chronic pancreatitis (author's transl)].

PMID- 1023718
TI  - The EMI general purpose scanner in the evaluation of pancreatic disease.

PMID- 1023719
TI  - Computerized tomography and ultrasonography in pancratitis.

PMID- 1023720
TI  - [Possibilities and limitations of the classic radiological examination in the
      diagnosis of primary chronic pancreatitis (author's transl)].

PMID- 1023721
TI  - [Contribution of the classical and angiographic x-ray examination to the
      diagnosis of chronic pancreatitis (author's transl)].

PMID- 1023722
TI  - Ultrasonic diagnosis of chronic pancreatitis.

PMID- 1023723
TI  - [Our experience with pancreatic echotomography (author's transl)].

PMID- 1023724
TI  - [The value of echotomography in investigating pancreatopathies].

PMID- 1023725
TI  - [Possiblities and limitations of the angiographic examination of chronic
      pancreatitis (author's transl)].

PMID- 1023726
TI  - The pancreas, a correlation of function, structure and histopathology.

PMID- 1023727
TI  - Functional exploration of chronic pancreatitis by duodenal intubation.
      Comparative study of the Lundh meal and duodenal hormones based on a survey of
      literature. Secretin-caerulein test carried out by the authors. Prospective
      conclusions.

PMID- 1023728
TI  - [Primary chronic pancreatitis. A classification based on endoscopic
      pancreatography (author's transl)].

PMID- 1023729
TI  - [The surgical indication in cases of chronic pancreatitis (author's transl)].

PMID- 1023730
TI  - [Surgery in chronic pancreatitis. A survey of a homogenous series of forty cases
      (author's transl)].

PMID- 1023731
TI  - [Surgical tactics in chronic pancreatitis (author's transl)].

PMID- 1023732
TI  - [Comparison between the pathological and microradiological data recorded in a
      series of surgical cases of chronic pancreatitis and the examination of necropsic
      material (author's transl)].

PMID- 1023733
TI  - [Results of surgical treatment of chronic pancreatitis. Review of the literature
      (author's transl)].

PMID- 1023734
TI  - [Treatment of chronic pancreatitis with threefold total by-pass (pancreas, bile
      duct, stomach). A ten years experience (author's transl)].

PMID- 1023735
TI  - Iron turnover in chronic hepatitis.
AB  - Radioisotope studies of iron kinetics carried out in patients with chronic
      hepatitis yielded the following results. Serum iron level and free iron binding
      capacity showed little difference from the normal mean value. All three types
      studied (chronic persistent hepatitis, chronic active hepatitis, chronic active
      hepatitis with cirrhosis) revealed an abnormal distribution of iron in the first
      24 hours. Normalization of iron distribution ensued in persistent hepatitis and
      in chronic active hepatitis with cirrhosis, but in chronic active hepatitis the
      abnormal distribution persisted, as reflected by a decreased iron utilization and
      an increased iron storage in the liver. The cause of this is attributed to a
      transitory accumulation of ferritin in the liver.

PMID- 1023736
TI  - Immune reactivity in subjects remaining tuberculin-negative after repeated BCG
      vaccination.
AB  - Thirty-four children of 12 years mean age having had 3 to 5 BCG vaccinations
      owing to tuberculin negativity, were subjected to cellular and humoral immune
      assays (tuberculin skin test, leucocyte migration test, lymphocyte transformation
      test, estimation of serum IgG, IgA, and IgM levels). It was found that
      nonreactivity may cease by the age of 11 to 12 years. At the time of study 21 of
      the 34 children were already tuberculin-positive and only 13 failed to react to 5
      TU. The studies confirmed the presence of combined immune deficiencies (negative
      tuberculin test, negative leucocyte migration test, abnormal immunoglobulin
      levels) as well as of changes confined to the individual immunoglobulin classes.
      In the case-history recurrent febrile diseases were found to occur more
      frequently between the 1st and 6th year of life than between 6 and 12 years of
      age. It is suggested that nonreactivity to tuberculin results from a congenital
      partial cellular immune deficiency.

PMID- 1023737
TI  - Surgical treatment of Cushing's disease caused by adrenocortical hyperplasia:
      experiences with bilateral adrenalectomy.
AB  - Experience with the surgical treatment of hypercorticism caused by bilateral
      adrenocortical hyperplasia in 16 patients is discussed. The treatment of choice
      is bilateral total adrenalectomy. Following subtotal adrenalectomy recurrence
      occurred in three of six patients; a third operation was needed in two cases,
      while permanent hypadrenia developed in the third. There was no operative
      mortality. One patient died 9 years after surgery, but the death was not related
      to the original disease. The clinical symptoms of hypercorticism subsided in
      every totally adrenalectomized patient. Indication and contraindication of
      adrenalectomy, the surgical method, and the problems of pre- and postoperative
      treatment are discussed.

PMID- 1023738
TI  - Distribution of caries among tooth types in fluoride and non-fluoride areas.
AB  - A method is described for estimating the preferential caries protective action of
      fluoride on certain morphological types of permanent teeth. The results  of an
      analysis by this method, applied to data for 1164 Austrian school-children aged 6
      -14 years, are reported. There was no indication that fluoride would exert its
      caries inhibitory effect selectively on certain types of teeth. Tentative
      explanations are put forward for the only inconsistency within the general
      results observed in 11--14-year-old children having a total of 3 carious teeth.

PMID- 1023739
TI  - The distribution of 3H-gastrin and 14C-pentagastrin in the blood and lymph of
      rats.
AB  - 3H-gastrin (0.83 mug/rat) or 14C-glycine-pentapeptide amide (100 mug/rat) were
      injected into the femoral vein in various groups of rats and radioactivity was
      measured in the arterial blood plasma and thoracic duct lymph in consecutive 5-
      10 min. periods for 60 minutes. Radioactivity excreted in the bile for 30 minutes
      was injected into the blood and lymph was followed for 120 minutes. It has been
      observed that labelled gastrin or pentagastrin activity reaches its peak in the
      plasma in the 5th minute after intravenous injection. Next, activity in  the
      plasma decreased after the injection of labelled gastrin, but remained unchanged
      after the injection of labelled pentagastrin. In the lymph, radioactivity reached
      its peak value between 5--15 min. after the injection of the labelled hormones.
      This peak value was two- to threefold of plasma radioactivity measured at the 
      same periods.  After the intravenous injection of labelled pentagastrin
      radioactivity was excreted in the bile; injecting this radioactive bile into the
      jejunal lumen, radioactivity was reabsorbed mainly into the blood circulation.

PMID- 1023740
TI  - Enzyme inducing effect of muscular exertion in the rat.
AB  - The activity of hexobarbital oxidase in vivo was found to be higher in rats
      forced to swim regularly (sleeping time studies). The enzyme inducing effect of
      spironolactone and norandrostenolone was reduced in trianed animals. Inactivation
      of the inducing agents is suggested to be faster in animals trained by swimming.
      The difference observed between test and control sleeping times was ascribed to
      an increased capacity of the liver to inactivate hexobarbital, while an
      alteration of central nervous responsiveness could  be excluded since the
      difference in serum hexobarbital concentratios was negligible when the animals
      awoke. Elimination of canrenone (dethioacetylated spironolactone) was faster in
      trained rats. Immediately after the swimming exercise hexobarbital elimination
      was slower in both the trained and the control groups. Accelerated elimination, a
      characteristic of physical fitness, could be observed to return 5 hours after
      terminating the exercise.

PMID- 1023741
TI  - The mast cells of the inner ear.
AB  - The presence of mast cells in the subepithelial connective tissue of the human
      endolymphatic sac has, to the best of our knowledge for the first time, been
      described. A hypothesis has been put forward in which these cells, which are
      known to contain histamin, heparin and serotonin, play an important role in the
      physiologic functions of the endolymphatic sac as well as in some pathologic
      states of the inner ear.

PMID- 1023742
TI  - [The crico-thyroid chondromas].

PMID- 1023743
TI  - [Cervical nystagmus and functional disorders of the cervical column].
AB  - Our experience concerning the necktorsion-nystagmus has convinced us that this
      type of nystagmus must be elicited via a proprioceptive mechanism. The course of
      the curve is very suggestive, as we can state that this nystagmus changes its
      direction every 3-4 seconds, following exactly the stimulating movement of the
      chair. Our investigations resulted in another very interesting statement.
      Examining also a group of normal subjects, we could state that more than 50% of
      them presented a necktorsion-nystagmus. In a group of patients with vertigo, we
      could elicit in nearly the same percentage a cervical nystagmus. A significant
      difference between the nystagmus observed in the normals and in the pathological
      cases, could not be deduced from our data, except that the pathological cases
      showed a little more intensive necktorsion-nystagmus. A functional examination of
      the mobility of the cervical spine showed a significant relationship between a
      movement restriction of CO-C1 and the presence of necktorsion-nystagmus. This
      proves also the nystagmus starts via a proprioceptive mechanism, interfering with
      the labyrinthine in-put at the vestibular nuclei. Without doubt, the necktorsion
      nystagmus is not a direct expression of a vertebro-basilar insufficiency and is
      even not a true pathological sign. Its clinical value is to be re-evaluated.

PMID- 1023744
TI  - [Posterior tympanotomy].

PMID- 1023745
TI  - [Corrective surgery of the bony nose].

PMID- 1023746
TI  - [Does Wrisberg's intermediary neuralgia exist?].

PMID- 1023747
TI  - [Transconioscopy, technic and indications].

PMID- 1023748
TI  - [Surgical anatomy of the fossa pterygopalatina].

PMID- 1023749
TI  - [Audibility in noise].

PMID- 1023750
TI  - [Indications for section of the vidian nerve].

PMID- 1023751
TI  - [Functional emptying of the neck. Technic, indications, results].

PMID- 1023752
TI  - [On mediastinoscopy].

PMID- 1023753
TI  - [Analysis of the neuromuscular disorders in the otorhinolaryngological sphere in
      patients with cerebral palsy].

PMID- 1023754
TI  - The prevention of coronary atherosclerosis.

PMID- 1023755
TI  - Fatal tubulo-intestitial nephropathy with chronic cholestatic liver disease.

PMID- 1023756
TI  - Oxygen tension in arterialized cutaneous blood and lung function in asthmatic
      children.

PMID- 1023757
TI  - Obligatory poliovaccination in Belgium: ten years after.

PMID- 1023758
TI  - Association of asymmetric crying facies, malformation of the ear and pulmonary
      agenesis.

PMID- 1023759
TI  - Complete type of double-inlet inverted left ventricle with L-transposition of the
      great vessels.

PMID- 1023760
TI  - Intraneuronal indolamines in the central nervous system.

PMID- 1023761
TI  - DNA and RNA tumor viruses--molecular events of virus replication and cell
      transformation and role in human cancer.

PMID- 1023762
TI  - Steroid hormone regulation of gene expression.

PMID- 1023763
TI  - Molecular and cellular mechanisms of chemical carcinogenesis.
AB  - Clearly, the technics of transformation in epithelial cell cultures bring us
      closer to understanding chemical carcinogenesis. Also clear is the need to
      develop new technics to evaluate the significance of viral particles found in
      tumors and to answer the basic question as to whether mutation or aberrant
      differentiation is the mechanism of chemical carcinogenesis.

PMID- 1023764
TI  - The scientific base and challenge of cancer diagnostic research.
AB  - A multi-approach study of the diagnosis of the common malignancies is underway.
      Screening of asymptomatic patients and early diagnosis, with the aid of new and
      sophisticated methodologies may arrive at the diagnosis of cancer at an earlier
      stage (i.e., before the tumor has metastasized). Table 2 summarizes many of the
      newer methods which might be incorporated into such a study.

PMID- 1023765
TI  - Cancer treatment combined modality approach.
AB  - Other approaches to determine whether patients have a high probability of
      metastases (and therefore no need for axillary dissection) have been the
      measurements of several circulating substances (e.g., polyamines, nucleosides,
      CEA and HCG). None of these are by themselves useful. There is a high percentage
      positive in those patients with metastatic disease (with up to 97% positive for
      either HCG, CEA, or guanosine (nucleoside). What we need is a correlation or a
      parameter of what the tumor cell number is, who to treat, and how long. Today's
      therapy is larger empiric. The ultimate goal is to individualize therapy. Figure
      1 summarizes a planned treatment for a woman with a breast cancer in 1974.

PMID- 1023766
TI  - Influence of geometry on growth of normal and malignant cells.

PMID- 1023767
TI  - The resting and growing states of the fibroblast.

PMID- 1023768
TI  - Tumor-specific immunity.

PMID- 1023769
TI  - Medical dominance. Psychoactive drugs and mental health policy.

PMID- 1023770
TI  - "Civil" commitment of the mentally ill and the need for data on the prediction of
      dangerousness.

PMID- 1023771
TI  - [Various aspects of experimental teratology].

PMID- 1023772
TI  - [Developmental interdependencies of structrual changes in man].

PMID- 1023773
TI  - The development of meninges in chicken embryos.

PMID- 1023774
TI  - [Fine structure of the human placenta].

PMID- 1023775
TI  - [Electron microscopy studies on skeletal-muscle capillaries in the white rat
      during pre- and postnatal development].

PMID- 1023776
TI  - [Electron microscopy studies on the differentiation of skeletal muscle fibers].

PMID- 1023777
TI  - [Specific effects of chemical teratogens after the completion of organogenesis].

PMID- 1023778
TI  - Some physiological aspects of genetic variation in the blood of sheep.
AB  - The principal genetic variants in sheep red cells and plasma are listed. Current
      hypotheses as to how the L blood group antigen affects active potassium transport
      across the red cell membrane are summarized. Recent work on an inherited defect
      in amino acid transport which results in a red cell GSH deficiency is also
      described.

PMID- 1023779
TI  - The contribution of isozymes to alkaline phosphatase activity in chicken plasma.
AB  - The contribution of different isozymes to plasma alkaline phosphatase (AP)
      activity was investigated in a White Plymouth Rock strain. No significant
      difference in AP acitivity between FF and FS genotypes was observed in both young
      chick and laying hen. As previously reported in young chickens, a significant
      difference in AP activity between F and S types was observed in laying hens. Of
      the total variance of AP activity 53%, 9% and 5% were explained by isozyme type,
      family and sex, respectively. The higher activity of the F band was responsible
      for the higher activity of the F type in the young chicken, while the activity of
      the B band of either type did not contribute to activity difference. The
      hypotheses are proposed so as to the activity difference.

PMID- 1023780
TI  - Biochemical gene markers in the gerbil Tatera brantsii from Lesotho.
AB  - Several geographically separated populations of the gerbil Tatera brantsii were
      investigated with protein and enzyme gene markers. Genetic variation was found in
      the following systems: serum albumin, 6-PGD, haemoglobin, esterase, IDA and GPI.
      No variation was found in the SDH and LDH systems. There appeared to be only
      slight differences in gene frequencies between populations. No real seasonal
      variation in any of the frequencies could be established.

PMID- 1023781
TI  - Observations on blood plasma postalbumins and hatchability of chickens.
AB  - In chicken blood plasma two bands have been observed in the region of
      postalbumins. The genetically determined faster migrating band PasA was present
      in the blood plasma of all tested males in the plasma of a majority of the
      females. The slower migrating band (PasB) was only observed in the blood plasma
      of laying females and never in the blood plasma of males and non-laying females.
      The genotype of individuals of which the faster migrating band was present was
      determined as AA and Aa and of those lacking this postalbumin as aa. An excess of
      females over males was found from mating of male Aa x female Aa and male Aa x
      female aa. At the same time the percentage of hatched eggs was lowered
      respectively.

PMID- 1023782
TI  - [Coding of tumorous lesions in anatomopathology].
AB  - The writer presents an initial and brief analysis of the "International
      Classification of Diseases, adaptation to Oncology "(CIM-O), prepared by the
      World Health Organization based on the 9th revision of the International
      Classification of Diseases. The CIM-O includes a topographical code (location of
      tumors) and a morphological code (histopathology of tumors) and thus makes
      available to all specialists in carcinology, including anatomopathologists, an
      international work tool for the recording of their findings. The English edition
      of the CIM-O has just been published, and its version in French is in the
      progress of preparation. The CIM-O should become effective internationally on 1
      January, 1979.

PMID- 1023783
TI  - [Familial syndrome combining short small intestine, intestinal malrotation,
      pyloric hypertrophy and brain malformation. 3 anatomoclinical case reports].
AB  - Anatomoclinical study of 3 cases of an exceptional malformative condition
      characterized by: --extreme shortness of the small intestine, --mesenterium
      commune, --hypertrophic pylorus, --malformation of the central nervous system
      (heterotopia, absence of operculum temporale). Clinically this malformative
      condition is characterized by failure and inertia of the intestinal peristalsis
      producing at intervals of 10-15 days episodes of subocclusion, the repetition of
      which causes death. The syndrome is familial and seems to be of autosomal
      recessive inheritance. The absence of mechanical obstruction, the repeated
      failure of colostomy and ileostomy, the normal aspect of the myenteric plexuses
      verified by cytoenzymatic and silver stains allow to individualize this
      anatomoclinical syndrome and to rule out the hypothesis of Hirschsprung's
      disease, Chagas' disease, idiopathic megacolon or hypoplasia of the myenteric
      plexuses. The association of cerebral malformations leads to consider the
      responsibility of a lack of synthesis of a same specific intermediate factor
      which is up to now poorly determined, implicated in the neuronal migration and
      neuromuscular transmission.

PMID- 1023784
TI  - [Methods for study of soluble antigens in pathological anatomy].
AB  - The authors restate their personal researches about several antigen systems, viz.
      ACE, neurospecific antigens. They point out the complementarity of
      immunochemistry and immunohistochemistry which implicates a very precise
      methodology and utilization of rigorously monospecific immune serums with regard
      to the studied antigen. This conduces to reproducible, responsive and reliable
      techniques in optic microscopy but much less easily so in electron microscopy.
      These techniques are still partly experimental; but their application to the
      study of pathological tissues and especially of tumors may however be considered.
      The identification of histological types and the correlated evolution is
      suggested on hand of concrete examples.

PMID- 1023785
TI  - [Anatomoclinical study of 29 cases of acute necrotizing encephalitis.
      Demonstration of herpes virus in 24 cases].
AB  - The authors studied the cerebral lesions in 29 cases of acute necrotizing
      encephalitis. Electron microscopy showed the presence of typical herpes virus
      particles in 24 cases. In 16 of them the virus had been isolated from specimens
      of the brain taken by biopsy and in 8 other cases from autopsy specimens. In 3
      acute cases the search for the virus was negative and it was not carried out in
      the two cases with prolonged evolution. Only 6 patients have survived. Some
      peculiar varieties have beeen observed, i.e. two adolescents had temporal and
      almost entirely unilateral lesions, and two aged females had severely hemorrhagic
      necrotic areas which could have been confounded with vascular lesions. In these
      two later cases typical particles were present. Finally, one case showed within
      the same nuclei at once typical herpes virus particles and other viral structures
      of vermicular form, the origin of which could not be precised.

PMID- 1023786
TI  - [Extemporaneous histopathological examination in neurosurgery. Report on 500
      cases].
AB  - The authors review 500 extemporaneous histopathological examinations done in a
      neurosurgical unit over a 16-month period. The following four questions are asked
      by the neurosurgeon: is there a tumor? is it a primary or secondary one? what
      variety is it? what is its degree of malignancy? The percentage of errors was
      respectively: 2 per cent, 2.2 per cent, 8.8 per cent and 7.4 per cent, or
      roughly, a percentage two times lower than in a series from the same laboratory
      done before the use of the low-temperature microtome. It especially seems that
      the tumoral variety is often determined accurately in meningiomas, neurinomas,
      medulloblastomas and craniopharyngiomas. In gliomas the variety is often more
      difficult to accurately affirm, and especially the "grade" of malignancy. The
      authors analyse the problems raised by the different types of tumors.

PMID- 1023787
TI  - [Cylindrical epithelioma of nasal cavities and accessory sinuses. Anatomoclinical
      study of 26 cases].
AB  - Report of a series of 26 cases of cylindrical epithelioma of the nasal cavities
      and accessory nasal sinuses. These neoplasms constitute a remarkably homogenous
      group the main characteristics of which are following: -- uniform histological
      pattern, similar to that of the epitheliomas of the colon, -- ethmoidal location
      in almost all cases, -- preferential occurrence in wood-workers, for instance in
      the Bas-Rhin. The prognosis depends on the extension of the epithelioma verified
      in 16 patients during the intervention. Recurrences caused death in 13 patients
      of this series. Ganglionic or distant metastases are rare. Six patients, i.e. 24
      p. 100 had a favourable evolution of at least 3 years. Discussion about the
      therapeutics of the primary tumor and of its recurrences.

PMID- 1023788
TI  - [Transduction of drug resistance factors and colicinogenic properties by
      bacteriophage phi-gamma (author's transl)].
AB  - Bacteriophage phi-gamma is capable of transducing long segments from hybrids
      R,Col,Trp plasmids carrying its prophage attachment site, even in absence of
      definite integration therein. Transductants inherite segments adjacent to the
      attachment site which may comprise determinants of drug resistance and of
      colicinogeny. Presence of a related plasmid in the recipient may have a helping
      effect probably in allowing recombination of the transduced genes with a
      replicon.

PMID- 1023789
TI  - [Ultrastructural study of host-parasite relationships in epidermis during
      "Trichophyton mentagrophytes" infection (author's transl)].
AB  - This study presents information concerning (1) location of fungal cells within
      the tissue, (2) subsequent tissue alterations and (3) behaviour of
      immunocompetent cells. 1) During initiation of infection, the fungal cells were
      found to be intracellular in the lower parts of stratum corneum. Digestion of
      intracellular keratin is obvious, but the resistant cell wall of the squames
      remain unaltered. During reinfection fungal cells were located intercellulary in
      the upper parts of stratum corneum. 2) The study of ultrastructural changes in
      the underlying viable parts of epidermis reveals many alterations of
      keratinocytes such as mitochondrial damage, lost of tonofilaments, vacuolization,
      and rupture of cytoplasmic bonds. The epidermal cells are disjoined by an
      oedematous reaction, and these manifestations may involve large epidermic areas.
      3) Cells, arising from the dermis, move into the intercellular spaces that
      originate from epidermal cellular dissociation. These cells are interpretated as
      corresponding mainly to lymphocytes, monocytes and macrophages. This cellular
      infiltration is intense. Most of the lymphocytes and macrophages are activated
      (even giant cells are to be observed). In addition, some of these cells may reach
      the stratum corneum, the area of parasitic location. The relationships between
      these manifestations and those related to cutaneous delayed hypersensitivity
      reactions are discussed. It seems possible to demonstrate the immunopathologic
      status of the reaction where some specific immunological manifestations appear to
      be related to the fungal growth acting in a special way by antigenic stimulation.

PMID- 1023790
TI  - Infection of congenitally athymic (nude) mice with Toxoplasma gondii.
AB  - Nude mice, congenitally lacking most thymus-derived lymphocytes, are neither more
      susceptible nor more resistant against primary infection with virulent T. gondii
      cells than normal control mice. Both mouse groups died at the same time after
      intraperitoneal infection. Treatment with sulfadiazine protected both mouse
      groups against acute fatal disease. After termination of treatment with
      sulfadiazine the Nude mice gradually died, whereas the normal hairy mice
      survived. The latter had developed high amounts of antibodies and protective
      immunity to an otherwise lethal challenge infection. In the serum of Nude mice no
      antibodies could be detected. Pathologic alterations existed in the livers of
      Nude mice at the time of death.

PMID- 1023791
TI  - Laboratory investigations on neuroparalytic accidents associated with suckling
      mouse brain rabies vaccine. III. -- Preservation of vaccine potency after
      elimination of murine brain myelin by centrifugation.
AB  - Myelin, which has been found in nine day-old mouse brain, was eliminated from
      weanling mouse brain suspensions by centrifugation at 17,000 g for 10 min, as
      demonstrated by electron microscopy and guinea-pig inoculation tests for
      encephalitogenic activity. This centrifugation procedure did not affect the
      potency of seven batches of suckling mouse brain vaccine, when centrifuged and
      non-centrifuged samples of the same batches were compared by a modified NIH
      potency test (t = 0.17). The present results with weanling mouse brain
      preparations suggest that centrifugation at 17,000 g be used in the preparation
      of rabies suckling mouse brain vaccine instead of the 1,900 g currently employed,
      which does not eliminate myelin. This new procedure would be expected to reduce
      the number of postvaccinal reactions which are attributable to the small amount
      of myelin which remains in vaccines prepared with new-born animal brains
      following the current procedure.

PMID- 1023792
TI  - [The role of anastomosis resection in the treatment of stenosis of cervical
      trachea after resuscitation].
AB  - The authors describe a group of 9 resection anastomoses with end-to-end sutures
      of the cervical portion of the trachea after resuscitation. The operative results
      are analyzed first: in 8 cases the trachea recovered almost normal function in a
      very short time; one failure occurred : this was with a patient with considerable
      neuro-psychic sequelae following serious cranial traumatism. These results are
      then compared with 7 laryngo-tracheal plasties carried out according to the
      principles of Rethi's operation; it emerges from this study that circumferential
      resection followed by end-to-end anastomosis is still the ideal form of treatment
      for tracheal stenoses in view of the quality and consistency of the results.
      Operative technique is then described and, in giving their operative indication,
      the authors stress the need for medical and endoscopic treatment during the
      asphyxial crisis; this treatment is then suggested for removing the tube in open
      tracheal stenoses and in order to allow resection anastomosis with the trachea
      closed several weeks later.

PMID- 1023793
TI  - [Computer technology in otospongiosis. 2. Statistics on 15 years of
      stapedectomy].
AB  - To complete their two previous data processing studies on systematization of
      parameters for otospongiosis and on statistics concerning the otospongiotic
      disease itself, the authors now develop the study of postoperative functional
      results obtained over 15 years stapectomies performed according to various
      techniques. The characteristic of this study is that the functional results are
      not considered only from the operative technique point of view, but that they
      also take into account all the factors having an influence upon the functional
      results, i.e. mechanical operative factors, otospongiotic cochlear factors and,
      finally the patient's general factor. This work is divided in three parts. The
      first part considers statistical data drawn from investigating elements taken
      over a period ranging from 1960 to 1975 from operative findings, surgical
      techniques and operative complications, particularly during reoperations, i.e.,
      the mechanical part of hearing improvement in otospongiosis surgery. The second
      part deals with the problem of the medical postoperative care in stapedial
      surgery and with that of postoperative complications and the therapy used to
      combat them. It is the study of the cochlear support problem considering both the
      cochlear fragility facing the operative trauma, and the cochlear deterioration
      due to the enzymatic action of the otospongiotic microfoci of the lateral wall of
      the cochlear duct and of the vestibular side of the footplate. The third part is
      the statistical study made both by means of data processing and of manual
      investigation, on the long term functional results obtained, on one hand by the
      surgical solution of the stapedial fixation's mechanical problem, and on the
      other, by the medical solution of the cochlear problem considered both from the
      enzymatic and vascular point of view. This study of stapedectomies' long term
      functional results allows the authors to draw the conclusions which seem to
      result logically from this very elaborated statistical study concerning near
      17000 stapedectomies performed from 1960 through 1975.

PMID- 1023794
TI  - [Our experience with pulsed oxygen and general anesthesia in direct suspension
      laryngoscopy].
AB  - The authors describe a group of 77 direct suspension laryngoscopies in which
      general anaesthesia and oxygen therapy were used. The technique is described in
      considerable detail. The catheter used is independent of the laryngoscope and is
      passed into the nasal cavity. Analysis of the gases in the blood of 15 patients
      showed that after three minutes of apnea, ventilation was still satsifactory. No
      pneumothorax occured during this type of anaesthesia. For the O.-R.-L.
      practitioner using the method, the advantages are as follows: induction
      anaesthesia is quicker than after neuroleptanalgesia, exposure of the larynx is
      excellent due to curarization and three endoscopies can be carried out in the
      same operation: laryngoscopy,  oesophagoscopy and bronchoscopy. The disadvantage
      of general anaesthesia is that it makes it impossible to judge the mobility of
      the larynx. In 7,8 p. 100 of the cases, direct suspension laryngoscopy proved
      difficult or impossible to carry out fir anatomical reasons.

PMID- 1023795
TI  - [Effects on the level of medical responsibility of rhinoplasty complications].

PMID- 1023796
TI  - [The plastic surgeon and the request for rhinoplasty. Point of view of the
      psychiatrist].

PMID- 1023797
TI  - [Principal complications and factors for failure of rhinoplasty].

PMID- 1023798
TI  - [Respiratory problems after rhinoplasty].

PMID- 1023799
TI  - [Major complications of rhinoplasty].

PMID- 1023800
TI  - [Difficulties and failures in the surgical correction of concave and collapsed
      noses].

PMID- 1023801
TI  - [Failures and complications of rhinoplasties carried out by Cottle's method].

PMID- 1023802
TI  - [Correction of postoperative alar retraction by sub-mucosal dissection and free
      cartilaginous graft].

PMID- 1023803
TI  - Motor function of the stomach of non ruminant mammals in comparison to the molity
      of the abomasum.

PMID- 1023804
TI  - Retained placenta problems with induced labour in cattle.

PMID- 1023805
TI  - [Radioisotope technics in the study of drug metabolism and the determination of
      the levels of residues in the animal tissues].

PMID- 1023806
TI  - The effect of prostaglandin E2 on thyroidal secretion of hormonal iodine in the
      pig.
AB  - The thyroid gland isolated in situ in 4 pigs was perfused with PGI2 given at
      increasing rates (1.38, 2.75, 13.8, 27.5 and 138 ng/mn). In the all animals a
      significant dose-dependent reduction in hormonal iodine secretion rate was
      observed. These results confirm in vitro experiments with PGE1 (Burke et al.,
      1972).

PMID- 1023807
TI  - [Toxins of Byssochlamys nivea Westling. I. Preliminary study of toxicity in
      sheep].
AB  - The acute intoxication in 4 sheep, due to an extract from a Byssochlamys nivea
      culture containing patulin is attained by administering per os with a syringe or
      with an esophagal tube doses of patulin varying from 15 to 50 mg per kg of
      bodyweight. A dose of 20 mg/kg, given with a syringe, brought on the death of a
      sheep within 5 hours following the administration, while a dose of 50 mg/kg given
      by an esophagal tube, only led to some temporary and slight problems.
      Intoxication brings on such symptoms such as nasal discharge, the stoppage of
      ruminating, a painful sensitivity in the retro-sternal area, weight loss, and
      prolonged loss of appetite. With an autopsy, a sero-fibrinous peritoneal exsudate
      and considerable hemorrhaging in the abomasum can be found. Anatomo-pathological
      examinations pinpoint lesions in the liver and kidneys. Biochemical examinations
      revealed hemoconcentration followed by anemia, and a considerable drop in serum
      proteins. The urea level increases 24 hours after and attains a notable maximum
      at the 30th hour (50 to 200 per cent). During these acute intoxications, no
      disorder whatsoever in the nervous system was observed.

PMID- 1023808
TI  - [Several strains of Mycobacterium paratuberculosis: biochemical characteristics
      and allergic activity].
AB  - Judged from its biochemical properties and antigenic structure, Mycobacterium
      paratuberculosis is related to M. avium. When M. paratuberculosis was compared to
      B.C.G., several essential differences, were found that allowed their clear
      separation, within Runyon's Group III, M. paratuberculosis is differentiated by
      its biochemical properties as shown in the following table : (formula: see text).
      The allergic response of a guinea pig infected with M. paratuberculosis was
      stronger when an avium sensitine was used that when a bovine tuberculine was
      used.

PMID- 1023809
TI  - [Physico-chemical properties of 7-aminodesacetoxycephalosporanic acid].
AB  - 7-Aminodesacetoxycephalosporanic acid (7-ADCA) of 99 per cent purity was prepared
      by enzymatic hydrolysis of 7-phenylacetamidodesacetoxycephalosporanic acid. Its
      isoelecti point was determined by the electrophoretic method. Potentiometric
      titration of zwitterion of 7-ADCA was performed and the constants of its
      ionization were calculated. Minimum solubility of 7-ADCA zwitterion was
      determined and the curve of 7-ADCA solubility at wide pH ranges was estimated.
      Equilibrium of 3 forms of 7-ADCA was estimated.

PMID- 1023810
TI  - [Electron microscopic study of the structure of colonies of culture of
      Actinomyces parvullus producing actinomycin D].
AB  - Ultrafine structure of the mycellium of the colonies of active and non-active
      variants of Actinomyces parvullus, producing actinomycin D was studied.
      Functional rebuilding of the cells of the substrate and aerial mycellium during
      the colony development in connection with synthesis and accumulation of the
      antibiotic by the culture was shown. The process of production and secretion of
      an amorphous material in the cells of the substrate mycellium of the active
      variant of Actinomyces parvullus was studied. It was supposed that the above
      process was associated with the antibiotic synthesis by the organism cells. The
      phenomenon of intrahyphal growth of the hyphae observed in both the active and
      inactive variants of the colonies was rather characteristic of the cells of the
      culture studied.

PMID- 1023811
TI  - [Study of the composition of gas refuse in chlortetracycline production].
AB  - Varius classes of organic compounds, such as acids, aldehydes, ketones, alcohols
      and others getting into the atmosphere and polluting it were determined in the
      effluent gases of chlortetracycline production with chemical and physico-chemical
      methods.

PMID- 1023812
TI  - [Characteristics of a new aromatic heptaenic antibiotic, flavumycin A].
AB  - The study of the products of alkaline and acid hydrolysis showed that flavumycin
      A included mycosamine, an aminosugar and n-aminoacetophen, an aromatic fragment.
      The main functional groups of the antibiotics aglicone were determined.

PMID- 1023813
TI  - [Toxicity and pharmacological properties of carminomycin complex components].
AB  - Acute toxicity of the components of the carminomycin complex after intravenous
      administration to albino mice increased as follows. I less than II less than III.
      Component II induced a decrease in all the indices of the bone marrow and
      peripheral blood of the animals. It was most pronounced in dogs. The dogs died
      after administration of component II in the lethal doses as a result of the bone
      marrow aplasia. The indices of the functional state of the liver and kidneys in
      the animals after administration of components I and II changed slightly.
      Component III administered repeatedly to rabbits even in low doses induced
      significant impairments in the function of the liver and kidneys. Component II
      differed from component I by more pronounced cardiotoxicity. On the basis of the
      experimental data and the results published earlier component I is recommended
      for clinical trials as the least toxic one.

PMID- 1023814
TI  - [Relationship between nephrotixic effect of gentamicin and streptomycin and their
      blood levels in laboratory animals].
AB  - A principle of studying the nephrotoxic properties of drugs under conditions of
      maintaining their constant levels in the blood and dynamic registration of the
      nitrogen levels in the urea followed by histological examination of the kidney is
      proposed. Correlation between the levels of gentamicin and streptomycin in the
      cat blood during 4-hour infusion and the level of the nephrotoxic effect was
      found, gentamicin being much more toxic than streptomycin.

PMID- 1023815
TI  - [Lysozyme as a local defense factor in the gastrointestinal tract of patients
      with chronic diseases of the digestive organs].
AB  - No microbial growth in platings of the gastric juice of patients with gastric
      ulcer and chronic anacidic gastritis was observed. It means that the absence of
      hydrochloric acid in the gastric juice does not deprive it of any antimicrobial
      action. The possible role of lysozyme in providing sterility of the proximal part
      of the gastro-intestinal tract was studied. Eighty patients with chronic diseases
      of the digestive organs were observed. It was noted that the levels of lysozyme
      in the gastric juice was high and markedly exceeded the maximum concentrations
      required for lysis of organisms most resistant to it. The maximum concentration
      was determined at pH of the gastric juice equal to 7.0-7.5 (265 gamma/ml+/-28).
      No lysozyme in the content of the duodenum and jejunal juice was found in most
      cases. Its presence in the above parts of the gastro-intestinal tract was mainly
      associated with microbial growth. The maximum concentration of lysozyme (40
      gamma/ml) in the jejunal juice was observed in a female patient with chronic
      enterocolitis and significant microbial proliferation in the thin colon (more
      than 10(4) microbial bodies per 1 ml of the juice). Such parallelism between the
      presence of lysozyme in the gastric juice and microbial proliferation in it may
      be considered as a protective-adoptive reaction of the host.

PMID- 1023816
TI  - [Effect of prodigiosin on the lysozyme activity in melioidosis].
AB  - Decreased lysozyme activity was observed under conditions of melioidosis
      intoxication in rats induced by intraperitoneal administration of an acetone
      killed 3-day culture of the bacterial mass of the melioidosis causative agent.
      When prodigiozan was administered 48 hours by the 4th day which was indicative of
      prodigiozan activation of the factors of the microbial non-specific resistance.

PMID- 1023817
TI  - [Study of the effect of tetracycline, prodigiosin and their combination on the
      dynamics of phagocytosis of plague bacteria].
AB  - The advantage of the combined use of prodigiozan and tetracycline was observed in
      tissue culture of peritoneal macrophages of albino mice. Earlier digestion of the
      intracellular Y. pestis EV by the animal macrophages exposed to prodigiozan and
      treated with tetracycline was noted. It was shown that the macrophages preserved
      during several hours of cultivation in vitro their properties acquired in the
      animal organism under the effect of the substances administered.

PMID- 1023819
TI  - The surgeon and his complications.

PMID- 1023818
TI  - [Clinical evaluation of antibiotic therapy of NAG-infection].
AB  - It is not concluded yet whether it is expedient to use antibiotic therapy with
      respect to patients and vibrio-carries with NAG-infection. Observation of a group
      of patients with acute gastro-intestinal infections caused by NAG-vibrio and
      carriers of NAG-vibrioes showed that the rate of vibrio isolation after a course
      of antibiotic therapy (tetracycline, levomycetin) significantly decreased as
      compared to that in the group of the patients subjected only to symptomatic
      therapy. The data of the study provided recommendation of antibacterial therapy
      with respect to patients with NAG-infection especially in cases with accompanying
      infections or invasions. As for "asymptomic" carriers antibiotic therapy is
      required only with respect to persons with repeated vibrio isolation.

PMID- 1023820
TI  - Mortality and complications in a department of surgery (1969-1974).

PMID- 1023821
TI  - Thoracotomy under local anaesthesia: personal experiences in 215 cases.
AB  - The underlying pathophysiology and technic of thoracotomy with local anaesthesia
      for the surgical treatment of pulmonary tuberculosis and other intra- and
      extrapulmonary diseases is described. The immediate as well as the long term
      results in 187 patients with 215 operations were favourable. In view of these
      results the described method of thoracotomy with local anaesthesia  is to be
      preferred to an incorrectly administered general anaesthesia. However, it is
      beyond any doubt that in the presence of qualified anaesthetists and adequate
      equipment thoracotomy with general anaesthesia is preferable to local
      anaesthesia. However, wherever the conditions for expert application of general
      anaesthesia are lacking and surgical treatment of lung diseases is necessary,
      thoracotomy with local anaesthesia is an acceptable and reliable substitute.

PMID- 1023822
TI  - Popliteal artery entrapment; claudication during youth.
AB  - We report four patients who presented early in life with intermittent
      claudication, caused by popliteal artery entrapment. In three of them this was
      the result of an abnormality in the anatomy of the popliteal fossa. In the
      fourth, however, muscular hypertrophy alone led to arterial entrapment. Three
      patients were successfully treated by simple myotomy. In the fourth arteriography
      showed a total occlusion of the popliteal artery. An arteriotomy was performed.
      In was then seen that the vessel was still patent, and the opening was closed
      with a vein patch. The result of this procedure was also satisfactory. It is the
      authors' opinion, based on their own experience and that of other workers as
      reported in the literature, that vascular reconstruction is only indicated when
      irreversible vascular changes have occurred, or where other lesions have
      complicated the condition.

PMID- 1023823
TI  - The alveolar soft-part sarcoma. A clinically malignant, neuro-endocrine tumor,
      possibly originating from the tissue composing the paraganglia.
AB  - The cases of two young women with alveolar soft-part sarcomas (ASPS) in one of
      the upper extremities are reported. The ASPS is a relatively rare malignant tumor
      of the soft parts that grows slowly and shows a predilection for the extremities;
      it occurs most often in young women. The tumor is deceptive in that the clinical
      impression is benign. So far, the only method of treatment is ample surgical
      excision. The tumor appears to be scarcely radio-sensitive and primary cytostatic
      therapy gives very little response. Histogenetically, the tumor is related to the
      neuro-endocrine paraganglion system. The long-term prognosis of the tumor is
      unfavorable.

PMID- 1023824
TI  - Reduction mammaplasty followed by development of a bilateral non-synchronous
      carcinoma of the breast.
AB  - Case report of a woman who at the age of 26 underwent mammary reduction
      (strmbeck) for macromastia. A primary bilateral non-synchronous carcinoma of the
      breast was discovered 20 months and 5 years after the plastic surgery. On
      pathological examination lymph node metastases were not found in both instances.
      There was a positive family history of the occurrence of carcinoma. Mammography
      prior to mammary reduction is recommended.

PMID- 1023825
TI  - Ascites in benign disease of the pancreas.
AB  - Ascites in benign disease of the pancreas is a rare observation. One patient with
      this condition is discussed. The key to the diagnosis is the raise of the amylase
      and protein content of the ascitic fluid. The condition is caused by pancreatic
      juice oozing into the free abdominal cavity through a rupture of the pancreatic
      duct or a pancreatic cyst. Surgical treatment may result in recovery.

PMID- 1023826
TI  - [Interpretation of stress-electrocardiography].

PMID- 1023827
TI  - [Persistent atrioventricular canal. Differential diagnosis of its variations].
AB  - The authors reviewed 40 cases of endocardial cushion defect, 26 with the complete
      type and 14 incomplete. In 34 cases the diagnosis was corroborated anatomically
      and in the rest through angiocardiogram. 2. There is a discussion of proposed
      classifications and in accordance with the abnormality of the endocardial
      cushions, they outline the anatomic varieties. 3. They show that the complete and
      partial forms have notable differences in their clinical picture and in the
      prognosis. Particularly when there are associated malformations. They also give a
      detailed account of the essential data for the differential diagnosis. 4. In
      those cases with the partial type, the electrocardiogram showed typical behavior,
      whereas, in those with complete type the results were related to the associated
      malformations. 5. The anatomy of the persistence of endocardial cushion defect is
      analyzed and taking this into consideration, the problems which occur with mitral
      valve replacement are discussed. 6. They emphasize the importance of an excellent
      angiographic study, which besides its diagnostic value, is fundamental in making
      a decision in regard to surgical selection and technique. 7. They show the high
      frequency of malformations which may coexist with Endocardial cushion defect and
      remind us that as long as we continue to wait for classic data, especially of tb
      electrocardiogram, and ignore the left ventriculogram to establish the diagnosis,
      an important number of cases will remain undiagnosed. 8. They show that in the
      incomplete type there habitually exits situs solitus and the associated
      malformations are rare and simple; on the other hand in the complete, situs
      ambiguo was proven in 69.2% and solitus in the rest, and in 92.3% there were
      complex associated malformations. They affirm that with the suspicion or the
      confirmation of the complete type consider the possibility of it is imperative to
      heterotaxia. If this exist and there is low pulmonary flow we should suspect the
      coexistence with tetralogy of Fallot.

PMID- 1023828
TI  - [Anatomo-clinical study of arterioventricular disorders].
AB  - The relationship of the great arteries with their respective ventricles in the
      three toncoconal morphologies depends on the orientation and rotation of the
      septum of the trunk and cone. In this work we study a case of crossed great
      arteries and another of partial distortion of the great arteries and one of
      transposition of the great arteries, all with arterioventricular concordance. In
      the anatomic and angiocardiographic examples an analysis is made of the
      arterioventricular relation in each type of arterial pedicle. We say that
      arterioventricular concordance exists with crossed great arteries when the
      pulmonary originated from the anterior infundibulum and its direction of right to
      left or from left to right in the frontal plane shows the spacial position of the
      anatomically right ventricle. In the transposition of the great arteries or in
      the partial distortion of the great arteries with arterioventricular concordance
      the aorta in the frontal plane shows the spacial position of the anatomically
      right ventricle. In the first group the aorta originates from the anterior
      infundibulum while in the second, from the posterior infundibulum. We review the
      examples of arterioventricular discordance diagnosed by necropsy or by laboratory
      studies. We study 5 cases; 1 with crossed great arteries, 3 with transposition of
      great arteries and the last with partial distortion of the great arteries. In the
      arterioventricular discordances with crossed great arteries in the lateral
      position, we observe that the pulmonary artery originates from the anterior
      infudnibulum whereas in the transposition, the aorta emerges from the anterior
      infundibulum. In the partial distortion of the great arteries the vessels are
      side by side or the aorta a little bit anterior to the pulmonary which is
      connected with the anterior infundibulum. In the posteroanterior incidence when
      there exists an arterioventricular discordance with crossed great arteries, the
      direction of the pulmonary does not indicate the spacial position of the
      anatomically right ventricle. In the same way, in the transposition and in the
      partial distortion of the great arteries the aorta does not indicate the spacial
      position of the anatomically right ventricle. On the basis of the evidence
      obtained by experimental and descriptive embriology, the morphogenetic processes
      responsible for the arterioventricular relations are presented. The anatomic
      specimens of each example is analyzed and the adequate parameter for the
      diagnosis of the distinct varieties of arterioventricular relations are
      presented. Finally a review is made of the few cases found in the literature and
      the differential diagsis between the concordant and discordant troncoconal
      malformation is established.

PMID- 1023829
TI  - [Correlation between exercise test and coronariography].
AB  - In order to evaluate the sensibility and specificity of the maximal treadmill
      exercise-stress test, a correlation was made, in fifty patients, of the resus of
      the test and the findings at selective coronary arteriography. None of the
      patients had received cardioactive drugs previous to the study. Among twenty-nine
      patients with proven coronary disease, three had false negative exercise tests.
      The remaining twenty-six cases had positive tests. The sensitivity of the method
      (reliability in identifying the presence of disease) was 89.7%. Twelve of twenty
      one subjects with normal coronary arteries had negative exercise tests. In eight
      patients without coronary artery lesions, the exercise test was positive (false
      positive tests). An additional patient had an equivocal response and is included
      among the false positive responses. These nine-patients form a special group
      since they had severe heart disease, even though it was not due to
      atherosclerosis of the major coronary vessels. The specificity of the test
      (reliability in identifying the absence of disease) was 57.1%. However, in the
      absence of other heart disease, none of the subjects with normal coronary
      arteries had a false positive response. An analysis is made of the possible
      causes of these false negative and false positive responses. It was also shown in
      this study that the patients with coronary artery disease and positive treadmill
      tests had a definite functional aerobic impairment as well as a significant
      reduction in such indices of myocardial oxygen consumption as the heart rate and
      the double product (pressure-pulse), when compared to the subjects with normal
      coronary vessels and negative tests. In the group of patients with false positive
      responses, these parameters were not significantly different from the normals.
      The exercise-stress test protocol used in this study appears to have an adequate
      sensibility and an acceptable specificity.

PMID- 1023830
TI  - [Atrioventricular conduction disorders following total correction of tetralogy of
      Fallot. Analysis of the electrogram of the bundle of His].
AB  - A study was made of the electric activity of the atrioventricular (AV) conduction
      system in basal conditions and with atrial stimulation in order to discover the
      type, severity and prognosis of the AV disturbance in cases of total correction
      of tetralogy of Fallot. The authors studied thirteen patients from the Paediatric
      Department of the National Institute of Cardiology who had undergone such
      surgery, 7 males, 6 females from 3 to 22 years old. All presented advanced RBBB
      and sinus rhythm; in the immediate postoperative period, one presented complete
      transitory A-V block which required a stand by pacemaker; in 2 cases there was a
      first degree AV block; in two other, LAH and LPH. In 5 cases atrial stimulation
      was made with single charges and progressive frequency. Measurements were taken
      at the customary intervals. In basal conditions, prolongation of the AH interval
      was only found in 2 patients, both with first degree AV block in the peripheral
      EKG; both patients were taking digitalis. The HV interval was longer than normal
      in 3 cases, with one of these showing also a lengthened AH interval. The atrial
      stimulation showed prolonged ventricular activation in 2 cases, one of them with
      normal basal HV interval. The authors conclude that this procedure permits: 1)
      The discovery of alterations in the AV conduction system which could not be found
      in a peripheral EKG. 2) Localization of the site of the lesion. 3) The finding of
      disturbances of the ventricular conduction by atrial stimulation. 4)
      Identification of those patients who, after a complete correction of tetralogy of
      Fallot, show a potential high risk of developing complete complete AV block or of
      sudden death. 5) The establishment of a real prognosis in these patients.

PMID- 1023831
TI  - [Aerobic functional capacity in normal subjects].
AB  - The functional evaluation of a subject may be performed by measurement of the
      functional aerobic capacity by means of exercise-stress tests. The maximal oxygen
      consumption (VO2 max) is the best parameter to establish this. The values of VO2
      max were determined in twenty-five normal subjects, residents of Mexico City.
      There were twenty men and five women whose ages ranged between the third and
      fourth decades of life. A maximal exercise-stress test was performed in a
      treadmill, with constant inclination and progressive speed increments.
      Electrocardiogram and blood pressure were monitorized at rest, during exercise
      and in the recovery period. Four collections of espired gas were obtained, one at
      rest and three at different levels of exercise. VO2/kg. at rest (the value of one
      met) was 3.49+/-0.58 ml/kg. min. for the whole group somewhat lower for males
      (3.37+/-0.53 ml/kg. min.) than for female subjects (3.99+/-0.51 ml/kg. min.).
      These results are comparable to the ones informed in the literature. VO2 max/kg.
      was 27.8+/-5.57 ml/kg. min. for the entire group and 28.0+/-5.64 and 27.3+/-5.94
      ml/kg. min. for men and women respectively. The values of VO2 max/kg. are
      definitely lower than the ones obtained from normal subjects in other countries.
      Considerations are made on the possible causes of this discrepancy. A linear
      correlation was found between VO2/kg or mets in one side and load imposed,
      cardiac rate or double product (pulse-pressure) in the other. The different VO2
      max/kg. values found in this study as compared to the results obtained from other
      countries, serve to emphasize the need for each laboratory to establish its own
      normal values and to construct nomograms for the adquate evaluation of functional
      aerobic capacity. This, in turn, will permit the accurate and correct
      prescription of exercise for individual subjects or patients.

PMID- 1023832
TI  - [Angiographic diagnosis of congenital abnormalities of the coronary vessels].
AB  - A new classification for congenital anormaleis of the coronary vessels is
      presented. The fundamentals of pathophysiology in each entity, are discussed.

PMID- 1023833
TI  - [Results of 1000 electrocardiographic exercise tests. Their correlation with
      previous ischemic cardiopathy and arteriosclerotic risk factors].
AB  - Exercise electrocardiograms were done on one thousand patients referred to the
      laboratory of exercise tests for: suggestive symptoms of acute heart failure, old
      miocardial infarction abnormal resting ECG, or evaluation of coronary reserve.
      The average value of cardiac rate reached for the group, was close to 80%. The
      maximum exercise loads managed by the men were superior to those of the women,
      and in general those managed in the negative test were superior in relation to
      the positive tests. Of the one thousand cases, 20.2% had positive exercise ECG's.
      There was no difference inthe percentages of positivity between the two sexes,
      20.75% and 19.11% for men and women respecitvely. The percentages of positivity
      are greater in those subjects sent to the laboratory for suspicion of angina
      pectoris, old MI, or abnormal resting ECG, than in those referred for detection
      of ischemic heart disease. The groups of patients with diabetes mellitus,
      arterial hypertension, old MI, and abnormal resting ECG had the highest incidence
      of positive tests: 41%, 37.5%, 30.6%, and 28.2% respectively. The most frequent
      localization of the ST segment alterations was the anterior portion, with
      percentages of 85.1% similar to those mentioned in the literature. The frequency
      of arrithmias, of 12.4% in this group, is a little less than that described in
      similar groups, but it corroborates the predominance of non-lethal ventricular
      arrithmias. The mortality in the tests performed was null.

PMID- 1023834
TI  - [Long term prevention of thromboembolic accidents with acetylsalicylic acid in
      auricular fibrillation patients].
AB  - For the past few years various authors have reported the antiplatelet action and
      prolongation of bleeding time with the use of acetyl-salicilic acid. In the
      present work, we review the frequency of thromboembolism in a group of patients
      with rheumatic or sclerotic heart disease with atrial fibrillation, in which the
      treatment with coumarins was suspended and substituted for 1 gram of aspirin P.O.
      daily. The results were compared with a similar group studied by Cardenas and
      col. During the time of the observation 10 patients had 14 thromboembolic
      accidents, slightly predominated by the emboli in the inferior members and in the
      cerebral vascular territory. The mortality was 2.5% and in 9 patients hemorrhages
      of little importance appeared, which could have been caused by the ASA, although
      it can not be proven. In comparing the results of this work with the above
      mentioned of Cardenas, it appeared that the number of thromboemboli, of deaths,
      and secondary accidents in the group treated with ASA was less than in the group
      which received coumarin or which were maintained without treatment. Based on the
      results, it can be concluded that it is possible to substitute the coumarins with
      acetyl-salicilic acid in the prevention of thromboembolism, in patient with
      rheumatic or sclerotic heart disease with atrial fibrillation.

PMID- 1023835
TI  - [Use of cyclophosphamide in membranoproliferative glomerulonephritis].
AB  - A study was made of the effect of ciclofosfamide on the nephrotic syndrome,
      glomecular filtration rate, immuproteins clearance complement, and urinary
      sediment in 14 patients with membranoproliferative glomerulonephritis. It was
      found that the nephrotic syndrome disappeared in 7 out of 8 cases, the glomerular
      filtration rate increased significantly in 13 out of 14 patients, and there was
      no correlation between the action of the drug and the behavior of the
      immunoglobulins clearances, complement, and the urinary sediment. Neither was
      there found a correlation between the increased renal function and the
      histological spectrum.

PMID- 1023836
TI  - [Aortic coarctation in childhood. Surgical experience in 120 cases].
AB  - 112 cases of coarctation of the aorta and 8 cases of tubular hypoplasia of the
      aortic isthmus operated upon in the Children's Hospital "La Paz" from Madrid, are
      reviewed. All children were under 7 years of age. 64.2% of the cases of aortic
      coarctation were in the first year of life, 47.3% of them had associated lesions,
      being the most frequently present persistent ductus arteriosus and ventricular
      septal defect. Hospital mortality was 14.2%, what is considered as very
      acceptable. All the children operated upon for the correction of tubular
      hypoplasia of the aortic isthmus were in the first year of age. 75% of them had
      associated ductus arteriosus and ventricular septal defect, being hospital
      mortality of 62.5%. Most frequent postoperative complications and cause of death
      were due to broncopulmonary disorders secondary to the existence of a previous
      pulmonary hypertension.

PMID- 1023837
TI  - [Coronary fistula of the left ventricle. Report of a case treated surgically].
AB  - A case of a left coronary artery fistula to the left ventricle successfully by
      surgery treated is reported. The medical literature was reviewed, and it is
      concluded that because of the surgical low mortality rate, all cases of coronary
      fistula, diagnosed by angiography and cardiac catheterization, ought to be
      submitted to surgical treatment.

PMID- 1023838
TI  - [Circadian aspects of iron metabolism. Changes of total iron binding capacity in
      patients with liver cirrhosis and in apparently healthy persons].
AB  - A group of 8 patients (M) with liver cirrhosis were studied. Each subject was
      standardized with rest time extending from 22,00 to 05,00 and meals scheduled at
      08,00-08,30, 12,00-12,30, 17,30-18,00. Then was sampled at 04,00, 08,00 12,00,
      16,00, 20,00, 24,00. In each sample of serum were determined iron, T.I.B.C. and
      L.I.B.C. All data were analyzed by macroscopic approach (chronograms) and by mean
      cosinor. A significant circadian rhythm was detected in all parameters, with a
      statistically valid difference between normal subjects and patients with liver
      cirrhosis in the mesor of T.I.B.C. and L.I.B.C.

PMID- 1023839
TI  - [Clinical evaluation in liver diseases of a new blood coagulation test for the
      determination of factors II, VII and X].
AB  - A recently introduced clotting test designed for the assessment of liver
      insufficiency was used in 10 normal subjects, 10 with toxic liver disease, 10
      with chronic liver disease, and 10 with chronic liver disease, and 10 with
      cirrhosis of the liver. Comparison with the results of Quick's test, Normotest
      and thrombotest showed the new test to have excellent standardisation and good
      sensitivity in the detection of liver impairment.

PMID- 1023840
TI  - [A new system of analysis for partial thromboplastin time. Comparison with other
      blood coagulation tests in liver diseases].
AB  - A new analysis system for the partial thromboplastin test (Cephotest) has been
      applied to 40 subjects (normal, suffering from nutritional toxic hepatopathy,
      chronic hepatopathy and cirrhosis of the liver). The test was then compared with
      other blood clotting tests (Howell's test, PTT test, Quick's test, Normotest and
      Thrombotest) and proved to have very good standardization and sensitivity.

PMID- 1023841
TI  - [Final results of ultra-early diagnosis in congenital hip dislocation in the
      newborn infant population].
AB  - Data relating to the first year's work in ultra-early mass diagnosis of cases of
      congenital dysplasia of the hip are presented. Stress is laid on the importance
      of this type of screening as a means of preventing the crippling sequelae that
      this disease. Attention is drawn to the simplicity and cheapness of the
      examination. Particular reference is made to the notable frequency with which
      this form of dysplasia was observed in the children of parents known to be
      original inhabitants of the Sangone Valley.

PMID- 1023842
TI  - [Effect of Bunaftine on the ventricular tachycardia due to aconitine in the dog].
AB  - Suppression of aconitine-induced ventricular tachycardia in the dog with various
      doses of Bunaftine was attempted. Stable re-establishment of the sinus rhythm was
      achieved in only 3/15 cases, whereas in 3 tachicardia was unchanged, and in 9
      fibrillation appeared, due, it is thought, to the effect of the drug on
      myocardial conductivity, since fibrillation was the most frequent outcome when
      high doses were used.

PMID- 1023843
TI  - [Effect of Bunaftine on the aconitine-induced atrial arrhythmias in the dog].
AB  - Bunaftine has a quinidine-like vagolytic effect and does not act as a beta
      blocking agent. Its effect on aconitine-induced atrial fibrillation in the dog
      was examined. It led to suproventricular tachycardia in all cases, but re
      established the sinus rhythm in only 5/15. It is felt that this lack of success
      is attributable to the slowing of the frequency of the primary pacemaker on the
      part of the drug. Slowing down of atrioventricular and intraventricular
      conduction by Bunaftine was revealed by lengthening of the P-R interval and
      widening of the Q-RS complex. Decreased blood pressure following administration
      of the drug appears to be due to reduction of heart rate rather than altered
      myocardial inotropism or peripheral resistance.

PMID- 1023844
TI  - [Evaluation of the effects of 3,4,5-trimthoxy-benzoyl-e-amino caproic acid (ATBC)
      on the senile heart].
AB  - The marked positive inotropic effect of ATBC was noted in 20 senile patients free
      of ischaemic heart disease and is postulated as the basis of its action in such
      situation.

PMID- 1023845
TI  - [Heparin tolerance in relation to age and the presence of amyloidosis].
AB  - Clotting time under basal conditions and 30', 60' and 120' after 100 I.U.
      heparin/kg i.v. was determined in four groups:1) 15 healthy subjects aged less
      than 50 yr; 2) 27 "healthy" subjects over 65 yr; 3) 20 subjects with either
      myeloma (7 cases), benign monoclonal gammopathy (7) or rheumatoid arthritis (6);
      4) 4 subjects with amyloidosis (2 primary, 1 secondary to rheumatoid arthritis,
      and 1 secondary to myeloma). Rectal biopsy and a histological search for amyloid
      substance were carried out in all subjects from the 3rd and 4th groups. Heparin
      tolerance was too widely scattered to enable statistically significantly means to
      be deduced. Comparison between the arithmetical means of the four groups,
      however, showed a greater resistance in aged opposed to young subjects, and in
      patients with amyloidosis as opposed to those in the other three groups. This was
      constant and marked after 60' and 120', suggesting that this test may offer
      indirect evidence in support of a diagnosis of amyloidosis.

PMID- 1023846
TI  - [Various cases of acute gastroenteritis due to Salmonella Paratyphi C].
AB  - Five cases of acute gastroenteritis due to Salmonella Paratyphi C observed in the
      province of Trieste during 1975 are described. It is deduced from the clinical
      findings and the history in each case that this infection was imported, and
      favoured by the geographical location of the city and prior mutilating
      gastrointestinal surgery. The in vitro and in vivo effect of commonly employed
      antibiotics on this species is assessed.

PMID- 1023847
TI  - [Parasitic pseudotumors due to filaroid nematodes].
AB  - Four cases of subcutaneous pseudo-tumour caused by filaroid nematodes are
      described. The histological picture was marked by granulomatous reaction, with a
      necrotic centre containing filariae in various stages of regression.

PMID- 1023848
TI  - [Ultrastructure of the myocardium in experimental autoimmune cardiomyopathy].
AB  - The myocardium of 20 rats with an experimentally caused autoimmune form of
      cardiomyopathy was studied by the electron-microscopy method. It was established
      that lesions of the ultrastructure of the myocardium in this pathology were of a
      mosaic character. There was a clear-cut difference between the areas of complete
      destruction of myocytes and the zones of hypertrophy of the myocardium. These
      were divided into areas with complete hypertrophy of the myocardium and those
      with incompetent hypertrophy of muscular cells, which, in its turn, depended upon
      local conditions, in particular, on localization of a great number of collagenous
      fibres in the interstitial space.

PMID- 1023849
TI  - [Role of the changes in the sarcoplasmic reticulum in disorders of myocardial
      function].
AB  - Acute focal ischemia of the myocardium, acute hemodynamic overloading of the
      heart, coarctation of the aorta, and fibrillation of the heart were simulated on
      rabbits. The animals were studied for the contractile function of the myocardium,
      and potential work capacity of the heart was calculated according to a special
      formula. The rebbits were sacrificed at the acute period of the development of a
      pathological process, and the contractile myocardium was investigated by electron
      microscope. The studies of the bioelectric activity of the heart revealed
      periodically appearing disorders of the cardiac rhythm. The electron-microscopy
      investigation showed, apart from changes in the ultrastructure of cells of the
      contractile myocardium reflecting their hyperfunction, marked dilatation of small
      canals of the sarcoplasmic reticulum, right to the formation of cisterns
      containing sequesters of cells. It is established that the changes referred to
      above in the sarcotubular system were associated with potassium dysbalance. The
      conclusion was drawn that the above said changes in the sarcoplasmic reticulum
      was a stereotype reaction of the alterative heart at the level of ultrastructures
      developing according to the principle of a vicious circle.

PMID- 1023850
TI  - [Morphological characteristics of the myocardium of rabbits in experimental
      arteriosclerosis].
AB  - Histological, histochemical, and electron-microscopy studies of the myocardium of
      70 rabbits were conducted; experimental atherosclerosis of the aorta in rabbits
      was caused by periodic four-fold fasting in combination with additions of crystal
      cholesterol to the diet. Along with the development of the ahterosclerofic
      process in the aorta, in the myocardium there were noted changes in the
      endothelium of capillaries, a more intensive production of acid polysaccharides
      by fibroblasts, a progressing development of the collagenous stroma, a higher
      heterogeneity of the contractile myocardium, and grave impairment of the
      structure and functions of the mypcardial cells (appearance of atrophying
      muscular cells with a decrease in the number of myofibrils) long before the onset
      of morphological changes in the coronary arteries.

PMID- 1023851
TI  - [Principle of asynchronism of the working cycles of analogous structures].
AB  - Electron-radioautographic investigations of the RNA synthesis were carried out in
      hepatocytes of intact and poisoned with CCl4 mice, fibroblasts of the granular
      tissue, and in neurons of the parietal region of the cerebral cortex of intact
      animals. Experimental mice were injected uridine-5H3. It was noted that the
      analogous structures differed from each other as to their appearance and to the
      number of argentum grains above them. These differences appearently were due to
      the fact that at the moment of fixation of the material these structures were at
      different phases of the working cycle. Owing to nonsimultaneity of the work of
      the structural elements optimal conditions for their physiological regeneration
      and adaptive variations in the functional activity of organs were ensured and a
      harmony in the interrelationships between various organs and between the organism
      as a whole and the environment were achieved.

PMID- 1023852
TI  - [Morphological manifestations of secretory activity of the neutrophils in
      inflammation].
AB  - Neutropholic leukocytes of aseptic peritoneal exudate of rabbits differed from
      neutrophilic leukocytes of the blood in greater variability in the content of
      cationic proteins. Some lysosomes ceased to be stained on cationic proteins,
      which produced a false impression of degranulation of leukocytes.
      Ultramicroscopically, there was observed a "clearing" of the lysosomes content
      and its outflow into cytoplasm. Lysosomes acquired the shape of spherical "holed"
      bodies and were transformed into clear vacuoles with remnants of the electron
      dense material. The rupture of lysosome membranes led to an "explosive" type of
      liberation of the lysosome content into the cytoplasm. Partly degranulated
      leukocytes remained vital and activity moved about in a homologous serum.
      Following contacts with histone F1 leukocytes lost cationic proteins. The
      liberation of cationic proteins from leukocytic took place without destruction of
      leukocytes and lysosomes themselves.

PMID- 1023853
TI  - [Functional-morphological changes in the lungs in bronchial asthma].
AB  - Histological and immunohistochemical studies of 57 bioptic specimens of the
      mucosa of the main bronchi taken during an attack of bronchial asthma, and those
      of the lungs of 27 patients who had died on the attack, showed that in the course
      of the attack of bronchial asthma serous-desquamous allergic inflammation, which
      proceeded according to the type of hypersensitivity, of the immediate type,
      developed along the full length of the broncho-vascular barrier. It occurred
      under the effect of biologically active substances liberated in the reaction of
      the antigen with IgE. Immunochemically, there was detected luminescence of IgE on
      the basal membranes of the mucous glands, on the basal membranes of the mucosa,
      as well as in lymphoid, plasmic, and mast cells infiltrating the mucosa. In
      allergic inflammation in the bronchi there were noted drastic delatation and
      increased permeability of vessels of the microcirculatory bed, odema, migration
      of eosinophils, the mast-cell reaction with degranulation of mast cells, spasm of
      musculature, elevated permeability of the basal membrane, impregnation of the
      latter with plasmic protein with fibrin, hypersecretion and desquamation of the
      epithelium, hypersecretion of mucous glands. As a result of the inflammatory
      changes in the bronchial system disorders of the drainage function of the bronchi
      with obstruction of their lumens which were most pronounced in small bronchi and
      bronchioles, developed.

PMID- 1023854
TI  - [Fat of the subcutaneous adipose tissue in spontaneous panniculitisi (Weber
      Christian disease)].
AB  - Histochemical investigations of fat in nodes of lesions of the subcutaneous fatty
      tissue in 25 patients with spontaneous panniculitis were carried out. It was
      shown that the disease was not accompanied by accumulation in the subcutaneous
      fatty tissue of such lipids as cholesterol, phosphoglycerides or glycolipids.
      Changes in triglycerides with formation of fatty acids were observed in fatty
      cells already in the presence of a developed cellular reaction in the
      subcutaneous fatty tissue and apparently could not be considered as a trigger
      mechanism in pathogenesis of spontaneous panniculitis. The revealing of aldehydes
      and lipids in fatty cells and in lipophages may indicate to an oxidative
      character of the processes developing in fat in spontaneous panniculitis. A
      suggestion is put forward that in pathogenesis of panniculitis a certain role
      could be played by an impairment of oxidation processes of fat with excessive
      accumulation of peroxides of lipids.

PMID- 1023855
TI  - [Plasmocytic granuloma].
AB  - A post-mortem study of a case of plasma cell granuloma with obstructive polyposis
      of the major bronchi and foci of lesions of a various degree of maturation in the
      lungs, lymph nodes and kidneys in a woman aged 39 is described. The morphological
      peculiarities of plasma cell gronuloma justify its differentiation plasmocytoma,
      and also serve as the grounds for considering it as a systemic disease associated
      with reticuloendothelial cells proliferation.

PMID- 1023856
TI  - [Idiopathic jaundice in pregnancy].

PMID- 1023857
TI  - The conformational stabilities of tropomyosins.
AB  - The stability to denaturation by heat and guanidine hydrochloride of seven
      vertebrate (including skeletal, cardiac and smooth muscle) tropomyosins and three
      invertebrate tropomyosins was examined. The transition profiles were
      discontinuous and in many cases distinct plateaux were observed which indicated
      the presence of unique partially unfolded states at intermediate temperatures and
      guanidine hydrochloride concentrations. The denaturation by guanidine
      hydrochloride could be described in the majority  of cases by a model in which
      the native state unfolds to a partially unfolded stable intermediate which then
      unfolds to the completely denatured state. On this basis it was possible to
      estimate the free energies of unfolding in water. It was shown that part of the
      alpha-helical structure of tropomyosin is only marginally stable and the free
      energy of unfolding in water of this segment is less than values found for
      globular proteins, whereas another segment (or segments) has a stability
      comparable to that found for globular proteins. The stepwise unfolding may be
      explained in terms of the coiled-coil interactions in tropomyosin. Differences in
      stability were found between tropomyosins from different muscles of the same
      species as well as between species, no two tropomyosins giving the same
      denaturation profiles. The invertebrate tropomyosins showed a wider range of
      stabilities, that from scallop striated muscle being far more easily denatured
      than all the others. No correlation was found between the stability of
      tropomyosin and the type of regulatory system of the muscle. A comparison of the
      results from vertebrate and invertebrate species suggests that there has been no
      selection for proteins of higher or lower stability during the evolutionary time
      scale.

PMID- 1023858
TI  - Fatty liver and kidney syndrome in chicks. I. Effect of biotin in diet.
AB  - Fatty liver and kidney syndrome, a disorder of young chicks, was studied under
      laboratory conditions. Affected chicks had enlarged livers (hepatomegaly), an
      increased content of lipid in the liver, and an increased level of palmitoleic
      acid in the liver lipids. The disorder was observed mainly in chicks from young
      parent flocks, and was associated either with commerical diets which were
      subsequently found to be low in biotin, or with specially formulated low-biotin
      diets. A third factor, imposition of stress, was required to initiate the
      disorder. There was evidence of increased lipogenesis causing an increase of
      triacylglycerols in the liver lipids and an increased production of saturated
      fatty acids, particularly palmitic acid. Increased levels of palmitoleic acid
      resulted from an increased desaturation of palmitic acid. Under stress, affected
      chicks had low blood glucose levels, suggesting that gluconeogenesis was
      impaired. Since biotin-dependent enzymes are involved in both gluconeogenesis and
      lipogenesis, it would appear that the relevant enzymes respond differently to a
      deficiency of biotin.

PMID- 1023859
TI  - Preparation of metabolically active cell suspensions from wool roots.
AB  - A method is described for the preparation of metabolically active cell
      suspensions from plucked wool roots using the proteolytic enzyme trypsin. The
      suspensions consist of a heterogeneous population of cells which appear similar
      in morphology to follicle bulb cells, differentiating keratinocytes and possibly
      cells of the inner root sheath. The concentrations of trypsin and of inorganic
      ions for optimum activity of the suspensions have been determined, and the
      inclusion of EGTA was found to increase the yield of cells. The cell suspensions
      incorporate [14C]leucine, [3H]uridine and [3H]thymidine into acid-insoluble
      products, and are sensitive to the action of cycloheximide and emetine, but not
      to chloramphenicol or rifampin. Autoradiography has shown that the cells believed
      to be derived from the follicle bulbs show the greatest activity.

PMID- 1023860
TI  - The proteins of the keratin component of bird's beaks.
AB  - Birds' beaks have an outer shell of hard keratin which consists almost entirely
      of proteins which are very rich in glycine [about 30 residues per 100 residues
      (residues %)], contain moderate levels of tyrosine and serine (each about 8
      residues %), and which have relatively low contents of cystine (about 2-5
      residues %), lysine, histidine, isoleucine and methionine. Major protein
      fractions in the S-carboxymethyl form isolated from the beaks of six different
      orders of birds have similar amino acid compositions, isoelectric points (pH 4-2
      4-9) and molecular weights (13,000-14,500). Detailed chromatographic
      electrophoretic and compositional studies of the proteins of kookaburra beak
      reveal them to be a family of closely related proteins with only limited
      heterogeneity, in contrast to mammalian keratin systems. The major kookaburra
      beak fraction is similar in overall composition and molecular weight to fowl
      epidermal scale, kookaburra claw and turtle scute proteins and shows some
      resemblance to reptile claw protein. Beaks also contain small amounts of protein
      which are distinctly different from the major fraction but which resemble feather
      keratin proteins in composition and size.

PMID- 1023861
TI  - Sedimentation equilibrium studies on protein from kookaburra beak.
AB  - Fractionated samples of the soluble S-carboxymethyl proteins from kookaburra beak
      (Frenkel and Gillespie 1976) were examined by equilibrium sedimentation. The
      molecular weight was found to be 11,300 when the photoelectric scanning
      absorption optical system was employed and 13,700 when Rayleigh interference
      optics were used. Possible explanations for this difference are considered and it
      is concluded that it must arise from heterogeneity of the protein. Optical
      rotatory dispersion measurements indicate that the proteins probably exist as
      random coils in dilute aqueous buffer.

PMID- 1023862
TI  - Boophilus microplus: characterization of enzymes introduced into the host.
AB  - A number of enzymes, presumably secreted by larvae of B. microplus under natural
      feeding conditions, have been investigated in the skin of previously unexposed
      calves 4 h after infestation at the attachment site. Carboxylic ester hydrolase
      activity was demonstrated in the dermis, immediately adjacent to the mouthparts,
      or in the attachment cone, depending on substrate and reaction pH. The carboxylic
      ester hydrolase acting on naphthol AS-D acetate (2-acetoxy-3-naphthoic-O
      toluidide) at pH 7-1 was characteristically found in the dermis and not in the
      attachment cone. The use of specific inhibitors showed that this enzyme was
      primarily a B-esterase or carboxylesterase with possibly a small portion of C
      esterase or acetylesterase. It is postulated that carboxylic ester hydrolase
      could contribute to the dilation observed in the subepidermal capillaries
      adjacent to the attachment sites of unexposed animals, through the formation of
      plasma kinins. Other enzymes demonstrated in the dermis, adjacent to the
      mouthparts, were triacylglycerol lipase, as an aggregated deposit, and small
      amounts of aminopeptidase (microsomal) and monophenol monooxygenase.
      Aminopeptidase (microsomal) was also demonstrated in the attachment cone or
      adjacent epidermis, according to the substrate used. No activity was found in the
      host tissue, in association with the attachment site, for either alkaline or acid
      phosphatase, acetylcholinesterase or cholinesterase, peroxidase or amine oxidase
      (flavin-containing), despite the intense histochemical reaction for the latter in
      the tissues of larvae.

PMID- 1023863
TI  - Boophilus microplus: cellular responses to larval attachment and their
      relationship to host resistance.
AB  - The histology of early feeding lesions of the cattle tick B. microplus has been
      studied using 32P labelled larvae to standardize the duration of attachment.
      Critical studies were made on 3-h lesions in six separate experiments on
      different groups of British breed animals. Each group consisted of three animals-
      one previously unexposed to ticks, one of high resistance and one of low
      resistance. The degree of mast cell disruption, eosinophil concentration and
      degranulation, and the extent of epidermal vesiculation were all significantly
      greater at the site of attachment on highly resistant hosts. In previously
      unexposed animals there was no mobilization of eosinophils nor mast cell
      breakdown and no epidermal vesiculation. Possible immune mechanisms producing
      mast cell disruption and the infiltration and concentration of eosinophils are
      suggested, and the effect of eosinophil degranulation on larval attachment and
      feeding is discussed.

PMID- 1023864
TI  - Metabolism of cystine by Merino sheep genetically different in wool production
      IV. Rates of entry of cystine into plasma, measured with a single intravenous
      injection of L-[35S]cystine, and the subsequent incorporation of 35S into wool
      fibres.
AB  - Ten, 2-year-old Merino ewes from a flock selectively bred for high clean fleece
      weight (Fleece Plus) and ten from a flock bred for low clean fleece weight
      (Fleece Minus) were randomly divided between two dietary treatments: 600 or 1100
      g/day of pelleted lucerne hay. After 14 weeks, each ewe received an intravenous
      injection of L-[35S]cystine (66-4 muCi). Venous blood samples were collected at
      15 specified times until 8 h after the injections, and wool fibres were plucked
      until 65-75 days after the injections. Protein-free filtrates prepared from blood
      plasma were bulked within sample times for ewes from the same flock and dietary
      treatment. Equations relating the specific radioactivity of free cystine isolated
      from the bulked filtrates to time after injection contained three exponential
      terms. The entry rate and pool size of cystine estimated from these equations
      were greater in Fleece Minus than in Fleece Plus ewes (by 25 and 44% respectively
      for entry rate and pool size). Both traits were also higher in ewes offered 1100
      g lucerne/day than in those offered 600 g/day (58-7 v. 33-9 mg/h for entry rate
      and 19-2 v 11-8 mg for pool size). The concentration of free cystine in plasma
      was greater in ewes offered 1100 g lucerne/day (3-0 v 2-1 mg/1; P less than 0
      05), and greater in Fleece Minus ewes (3-0 v. 2-1 mg/l; P less than 0-05). The
      percentage of the injected radioactivity recovered in the wool clipped to day 70
      post-injection differed between genotypes and between dietary treatments (P less
      than 0.05), being greater in Fleece Plus than in Fleece Minus ewes, and greater
      in those offered 1100 g lucerne/day than in those offered 600 g/day. The
      relationships between 35S incorporated per 1000 fibres (R) and time after
      injection (t) were best fitted by equations of the form (formula: see text). For
      all sheep, n = 3. The coefficient of the second term was significantly greater (P
      less than 0-05) in ewes offered 1100 g lucerne/day, whilst the constant of this
      term was significantly greater in Fleece Minus ewes. The specific radioactivities
      of cystine incorporated into wool fibres (SRf) during various intervals of time
      after injection were derived from these equations and from the measured rates of
      output of cystine in wool. The equations computed to relate SRf to time after
      injection (t) were of the form (formula: see text). Again there were three
      components. The coefficient of the third component was significantly greater (P
      less than 0-05) in ewes offered 1100 g lucerne/day, whilst the constant of the
      second term was significantly greater in Fleece Minus ewes.

PMID- 1023865
TI  - Transfer of sulphur to the digestive tract of sheep.
AB  - The transfer of sulphate from plasma to digestive tract and from digestive tract
      to plasma in crossbred sheep was estimated by the use of isotope dilution
      techniques with Na235SO4. The passage of 35S along the digestive tract was
      simultaneously measured by reference to two inert radioactive markers infused
      intraruminally. In the first experiment, three sheep given a roughage-based diet
      containing 174 +/- 7 mg S/day received an intravenous infusion of Na235SO4 for 7
      days before collections were made of plasma and of digesta from the rumen,
      abomasum and terminal ileum. Similar collections were made in the second
      experiment in which four sheep received intraruminal infusions of Na235SO4. From
      estimates of infusion rate of 35S, specific radioactivity of 35S in plasma and
      digesta and rate of flow of sulphur in the digestive tract the following
      calculations were made: The transfer of sulphate from the plasma to the rumen was
      calculated as 29 mg S/day. Of this only 12 mg S/day passed as organic sulphur in
      digesta from the stomach. As the net gain of sulphur in the stomach in this
      experiment was 153 mg/day, sulphate transferred from the plasma contributed only
      a small amount of sulphur derived from endogenous sources in the stomach. In
      contrast, the substantial passage of 35S into the intestinal lumen during
      intravenous infusion of 35SO4 suggested that 38 and 41 mg S/day of the 236 and
      145 mg organic S/day flowing from the small and large intestine respectively was
      derived from plasma sulphate, corresponding to about 26% of the dose.

PMID- 1023866
TI  - Changes in plasma volume and haematocrit in intact and splenectomized sheep
      during feeding.
AB  - Changes in jugular haematocrit during daily 2-h feeding periods in trained sheep
      with and without spleens were compared with changes in the concentration of the
      plasma tracer radio-iodinated human serum albumin. Jugular haematocrit was
      increased by 16% in intact sheep and 9% in splenectomized sheep 20 min after they
      started to eat dry rations. The dilution of tracer in plasma, studied after
      mixing in the vascular system had been completed, showed four phases. Phase 1 was
      the rate of removal of tracer in the period before eating began. Phase 2 was the
      sudden increase in plasma radioactivity that occurred in the first 20 min of
      eating, indicating a loss of plasma from the circulation. Phase 3 was the
      decrease in tracer concentration during the remaining feeding period and phase 4
      was a post-feeding phase, characterized by a slower rate of decrease of tracer
      than during phase 3, implying that there was significant recycling of tracer
      during this phase. The sudden increase in plasma radioactivity, initiated by the
      onset of feeding, represented a reduction in plasma volume of 10-12%. Minimum
      plasma volume coincided with peak haematocrit values. The reduced plasma volume
      accounted for the increased haematocrit in splenectomized sheep, but only
      accounted for about half of the increase in intact sheep. The residual increase
      in haematocrit in intact sheep was most likely the result of splenic contraction.

PMID- 1023867
TI  - Disruption of the metabolism, motility and morphology of spermatozoa by injection
      of alpha-chlorohydrin into rams.
AB  - Ejaculated spermatozoa from rams given intramuscular injections of alpha
      chlorohydrin (25 mg/kg, daily for 5 days) were studied. Respiratory and
      glycolytic activity of the spermatozoa was almost entirely suppressed within 1
      day and motility had decreased within 4 days of the first injection.
      Morphologically abnormal spermatozoa appeared in ejaculates after 2 weeks. The
      most common abnormality was an increase in the number of spermatozoa with looped
      or bent tails. There was little change in the fructose or amino acid
      concentration of the seminal plasma. All effects of alpha-chlorohydrin were fully
      reversible. It is suggested that the initial primary mode of action of alpha
      chlorohydrin is to disrupt the metabolism of spermatozoa in the cauda epididymis.

PMID- 1023868
TI  - Oxygen uptake, glucose utilization, lactate release and adenine nucleotide
      content of sheep ovarian follicles in culture: effect of human chorionic
      gonadotrophin.
AB  - A study has been made of the oxygen uptake, glucose utilization, lactate release
      and cellular content of adenine nucleotides of isolated sheep ovarian follicles
      (4-6 min in diameter) maintained in organ culture, and of the effects on these
      parameters of the addition of human chorionic gonadotrophin (hCG). The mean
      oxygen consumption of the entire follicles when freshly isolated and of the theca
      and membrana components was 0-56, 1-08 and 0-05 mumol per milligram wet weight of
      tissue per hour respectively. About 8 mumol of glucose was taken up and 16 mumol
      of lactate released per milligram wet weight of follicular tissue per hour during
      the first 24-h period of culture. This rate reduced by about 30% for each
      subsequent day of culture, but was significantly increased by the addition of
      hCG. The mean ATP content of theca and granulosa tissues was 4-6 and 2-8 nmol/mg
      wet weight of tissue respectively. There was no discernable change in tissue
      adenine nucleotide content or energy charge ratio during the 3-day culture
      period, and prolonged exposure to hCG was without effect. Untreated follicles
      produced both oestrogen and androgens throughout the culture period. The addition
      of hCG resulted in a transitory stimulation in oestrogen secretion, inhibition of
      androgen secretion, and a marked and sustained rise in progestin secretion. It is
      proposed that the increase in glycolytic activity following exposure to hCG may
      relate to the activation of the granulosa cells coincident with a transference of
      steroid synthetic capacity from theca interna to membrana granulosa.

PMID- 1023869
TI  - Effects of progesterone and oestradiol on RNA and protein metabolism in the
      genital tract and on survival of embryos in the ovariectomized ewe.
AB  - The hormonal regulation of metabolism in the genital tract and the development of
      embryos during early pregnancy in the ewe have been examined. Ovariectomized ewes
      received injections of maintenance progesterone, oestrous oestradiol and priming
      progesterone according to schedules designed to simulate endogenous ovarian
      secretion during early pregnancy, around the time of oestrus and during the
      luteal phase of the oestrous cycle immediately preceding oestrus. The survival
      and development of embryos was dependent upon the dose of maintenaince
      progesterone and the duration of treatment at the time of transfer, but changes
      in progesterone dose did not change endometrial protein or RNA metabolism on
      particular days. Both priming progesterone and oestrous oestradiol were required
      for normal embryo development. Priming progesterone and oestrous oestradiol each
      increased endometrial RNA/DNA ratios during early pregnancy. There were no
      interactions between priming progesterone and oestrous oestradiol, their effects
      being simply additive. Neither maintenance nor priming progesterone had any
      effect on protein and RNA metabolism in the oviduct. It is suggested that in the
      intact ewe oestrogen secreted at oestrus and progesterone secreted prior to
      oestrus play important roles in the establishment of a uterine environment
      suitable for the subsequent normal development of embryos.

PMID- 1023870
TI  - Immunological testing in dermatitis.

PMID- 1023871
TI  - Clofazimine (laprene) in the treatment of discoid lupus erythematosus.

PMID- 1023873
TI  - Whither dermatology?

PMID- 1023872
TI  - Mycobacterium marinum infection.

PMID- 1023874
TI  - Dermatology in Penang, Malaysia.

PMID- 1023875
TI  - Cutaneous melanocytes in Queensland patients.

PMID- 1023876
TI  - Sweating--physiology and pathophysiology.

PMID- 1023877
TI  - The psychological aspects of sweating.

PMID- 1023878
TI  - Surgical aspects of hyperhidrosis.

PMID- 1023879
TI  - The management of psoriasis. Current practice at the Royal Adelaide Hospital Skin
      Clinic.

PMID- 1023880
TI  - [Research on enzymes of Mycoplasma: enolase of Mycoplasma hominis].
AB  - A screening of enzymes on cell-free extracts of various species of mycoplasmas
      revealed the presence of enolase (EC 4.2.1.11) in significative amount in M.
      pneumoniae and M. fermentans, in lower amounts in M. hominis, A. laidlawii and in
      trace only in U. urealyticum. The value of activity of the various mycoplasmas
      could be correlated with their metabolism. From 40 g of cell paste of M. hominis,
      2.5 mg of enolase purified over 70 folds, was obtained with successive steps of
      salt fractionation and column chromatography. Kinetic studies gave the following
      constants: Km for 2-phospho-D-glicerate, 0.7 x 10(-4)M; optimum of Mg++
      concentration, 1 x 10(-3)M; optimum of pH, 7.7 inhibition by fluoride and
      phosphate, I = 0.77 X 10(-12)M4. Molecular weight estimation indicated for the
      native enzyme a value of about 100,000 daltons. These data suggest closer
      similarities with the enolase of microorganisms like E. coli and yeast than with
      the genus Thermus or B. stearothermophilus.

PMID- 1023881
TI  - [New method for demonstrating HBs antigen saturated by its antibodies].
AB  - The modalities for the carrying out of a technique for the detection of HBs
      antigen, even when it is completely saturated by the relevant antibodies, and its
      results are set out. The technique includes the preliminary acidification of the
      test serum at pH 2.4, in such a way as to detach the antibody from the antigen,
      subsequently, the effect of the hearing (70 degrees C) for some minutes to
      destroy the antibody. On the contrary, at this temperature the immunological
      reactivity of the antigen remains satisfactory. Subsequently the neutralization
      is carried out with Veronal buffer, and the HBs Ag detection is performed by
      radioimmunoassay.

PMID- 1023882
TI  - [Pharmacological alteration of the antigenic properties of experimental leukemias
      detected by lymphocyte transformation].
AB  - It has previously been demonstrated that an in vitro antineoplastic treatment may
      induce new antigenic specificities in murine lymphomas. L1210 leukemia has been
      altered by DIC (L1210/DIC); drug-treated L1210 subline has been rejected by
      syngeneic animals. Here spleen cells from mice, normal or immune to L1210/DIC,
      have been stimulated in vitro by the L1210/DIC cells as measured by 3-h-thymidine
      uptake. Spleen cell stimulation did not occur with other syngeneic tumor cells
      and, as expected, spleen cells have been triggered by allogeneic cells. DIC
      induced antigens stimulating syngeneic lymphocytes, as allogeneic cells did, have
      been demonstrated on L1210/DIC cells.

PMID- 1023883
TI  - Clinical usefulness of CEA assay.
AB  - CEA is a normal constituent of fetal cells, which can reappear in entodermally
      derived neoplasms, following a de-repression process. In order to evaluate the
      correlation between CEA serum levels, pathological stage and histological type of
      tumour, and to define the usefulness of CEA in monitoring the patients with
      gastroenteric neoplasms, 177 patients (62 with gastric heteroplasia and 115 with
      large bowel carcinoma) were tested for CEA; 83 patients had pre-surgical CEA
      tests. It was observed that CEA positivity (serum levels greater than or equal to
      5 ng/ml, employing the technique here outlined), is higher in colonic than in
      gastric neoplasms, and in adenocarcinomas in comparison with undifferentiated
      forms, moreover depending on the pathologic stage. 108 patients were tested for
      CEA several times and a correlation between CEA variations and clinical evolution
      was observed. This investigation bears out the importance to monitor the patients
      with gastrointestinal neoplasms with CEA test, before and after surgery, to
      evaluate the usefulness of surgery and, when necessary, chemotherapy and,
      eventually, to adopt more suitable chemotherapeutic modalities.

PMID- 1023884
TI  - [Behavior of HBs Ag and HBs Ab in chronic hepatitis].
AB  - The preliminary results of the HB, Ag and HBs Ab assay, performed with
      radioimmunological techniques in 31 cases of chronic hepatitis, 13 of whom
      carriers of chronic aggressive hepatitis (C.A.H.), 9 of chronic persistent
      hepatitis (C.P.H.) and 9 of cryptogenetic hepatic cirrhosis (C.H.C.) of both
      sexes, are reported. The highest number of HBs Ag positive cases was observed
      both in C.A.H. (69%) and C.H.C. (55%); very lower the HBs Ag positivity both in
      C.A.H. (33%) and C.H.C. (33%). No correlation between HBs Ag positive and HBs Ab
      positive was observed.

PMID- 1023885
TI  - Effect of some antiblastic drugs on HeLa cells.
AB  - The antiblastic effects of the antimetabolites MTS, Ara-C, Bleomycin of the
      alkylating Thiotepa, of Peptichemio (alkylating and antimetabolic) and of
      Peptichemio-Bleomycin combination, were compared after 24 and 48 hr of treatment
      on HeLa cells. Ara-C, which inhibits typical mitoses, Peptichemio and MTX, which
      inhibit atypical mitoses, Thiotepa, which induces the highest percentage of
      pyknotic nuclei, showed a considerable effect on the nucleus. Peptichemio, and
      the combination Peptichemio-Bleomycin showed a significant effect on the
      cytoplasm (induction of vacuoles). After MTX and Peptichemio treatments, and
      after Peptichemio-Bleomycin combination (1 mug/ml), eosinophilic inclusions were
      evident both after 24 and 48 hr.

PMID- 1023886
TI  - Circulating IgE levels in hydatid disease.

PMID- 1023887
TI  - Colony forming activity, density distribution and morphological features of the
      stem cell population in primary myelofibrosis.
AB  - In four patients with untreated primary myelofibrosis, the peripheral-blood cell
      growth in agar culture (frequency of clusters and colonies) was studied. As cell
      sources, were used either the buffy coat or the fractions obtained from an
      albumin discontinuous density gradient, prepared according to Dicke's technique.
      Besides the agar culture, also morphological features of the blasts of the
      granulocytic cell series of the gradient fractions were investigated, in order to
      relate the above-mentioned cell parameters. The results, taken as a whole,
      pointed out: a) increase in circulating CFUc's (expressed as the number/10(5)
      nucleated cells) in the patients, when compared to the controls; b) high
      percentage of CFUc's with an abnormal specific density (below 1.062 in 3 out of 4
      patients); c) presence in 3 out of 4 patients, of two populations of blasts: one
      showing low specific density, small size, high N/C rate, high plating efficiency
      and no nucleoli; the other with a higher specific density and low plating
      efficiency, showing the typical morphological features of the myeloblasts.

PMID- 1023888
TI  - Immunological studies in cerebrospinal fluid of acute viral and tubercular
      meningitis.
AB  - The Authors studied the immunological characteristics of lymphocytes in
      cerebrospinal fluid, from children affected by acute viral or tubercular
      meningitis. A reduced P.H.A. response of C.S.F. lymphocytes was observed. The
      Authors emphasize the usefulness of applying some other specific markers of T and
      B lymphocytes to achieve further informations on immunological traffic of
      lymphocytes.

PMID- 1023889
TI  - Co-antibodies in human leptospirosis.
AB  - Investigations concerning the co-antibodies formed in the course of human
      leptospirosis and the extractive antigens of leptospiras were reviewed. As a
      whole, the results concerning leptospira antigens point, next to antigens of
      serotype, to genus-specific and intertype antigens deeply seated in the cells.
      These cannot be identified by the MAL test, and therefore are not related to the
      co-agglutinins in human leptospirosis. The associations of co-antibodies in human
      leptospirotic sera were analyzed, using the MAL and CF tests performed with 20
      pathogenic and water serotypes of leptospira. The results showed that in the
      course of human leptospirosis high titer co-antibodies are formed, both
      agglutinating and complement fixing, variably associated for one or more serotype
      antigens not belonging to the infecting strain. The various biological
      interpretations of the phenomenon were discussed and the hypothesis of antigenic
      changes of leptospira strains in vivo as well as in vitro was discussed, as a
      determining factor in the formation co-antibodies in leptospirosis.

PMID- 1023890
TI  - [Incidence and significance of the positivity of Widal's reaction in chronic
      active hepatitis and in liver cirrhosis].
AB  - Agglutinins to S. typhi and/or paratyphi A and B have been found in a high
      percentage of patients with chronic active hepatitis (54.5%) and liver cirrhosis
      (61.5%). The coproculture for Salmonella was constantly negative. Formulation
      some hypotheses able to explain these data, the Author points out the role played
      by the quantitative and qualitative alterations of the humoral immunity, typical
      of these liver diseases.

PMID- 1023891
TI  - [Behavior of specific antibodies against hepatitis B surface antigen in children
      with acute and chronic hepatitides in healthy carriers and in various co
      habitants of chronic hepatitis patients].
AB  - The Authors studied the behaviour of ABsAb in a pediatric case-list made up of 8
      cases of virus B acute hepatitis, and 63 cases of chronic hepatitis in different
      evolutive phases: besides, this investigation was extended to 48 healthy carriers
      (29 of whom bioptically confirmed) and 35 cases of cohabitants with HBsAg
      positive hepatic chronic patients. In acute hepatitis the antibody pattern, even
      if delayed in time, mimics the modalities of the organic response against
      exogenous stimulations, therefore it constitutes an index of past disease and
      recovery. In chronic hepatitis (both HBsAg-positive and negative) the specific
      antibody to the surface antigen is present only at a low percentage (27%) and
      generally at low titres. In healthy carriers, bioptically ascertained, it is
      practically absent as to suggest more careful consideration when it turns out
      present (pseudo-carriers?), while in the cohabitants with virus B patients,
      especially if chronic, along with HBsAg detection, it consitutes an indispensable
      element for their classification in patients, ex-patients, not infected and
      healthy carriers. A very interesting finding, requiring further confirmation, is
      the unusual behaviour of these antibodies in some cases of relapsed chronic
      hepatitis.

PMID- 1023892
TI  - Correlation between clinical course and CEA levels during chemotherapy.
AB  - In order to evaluate the correlation between clinical progress and CEA levels in
      gastroenteric tumours, particularly during chemotherapeutic treatment, CEA assay
      was performed on 330 patients (126 with gastric neoplasms, 204 with large bowel
      carcinoma). 175 out of these had a pre-operative assay. Moreover CEA test
      positivity (CEA larger than or equal to 5 ng/ml according to the technique
      employed by us) is higher in colon neoplasms compared with gastric neoplasms and
      in adenocarcinomas in comparison with undifferentiated forms; besides it depends
      on the pathologic stage. In colon tumours CEA test showed a higher positivity for
      left than for right forms (66.6% versus 38%). 240 patients were followed up with
      repeated CEA assays: the following observations were made: a - After radical
      surgery 72% of the patients shows normalized CEA values. b - In 198 patients who
      underwent radical surgery, not requiring chemotherapy, there was a close
      correlation between CEA levels and clinical evolution in 98% of the cases. c - 60
      out of 68 patients (88%) submitted to chemotherapy for advanced neoplasms show a
      close correlation between CEA response to the chemotherapy and clinical response
      (p less than 0.001). These investigations stress, above all, the importance of
      CEA test to monitor the treatments performed (surgical and chemotherapeutic) and
      to adopt, eventually, more effective chemotherapeutic modalities.

PMID- 1023893
TI  - Mycoplasmas in pregnant women and in newborn infants.
AB  - Mycoplasmas were isolated from 96 of 143 vaginal swabs of pregnant women on their
      first visit at the Prenatal Center. Ureaplasmas alone were isolated in a higher
      percentage than M. hominis alone or combination with Ureaplasmas. The isolated
      cultures at 36 weeks of gestation show no significant difference with the first
      visit isolation. Colonization of mycoplasmas were found in a higher percentage
      (93.3%) in the abnormal deliveries than in normal ones. Mycoplasmas were isolated
      also from throat swabs of 19 out of 141 newborn infants: the proportion of
      mycoplasmas positive infants was higher in low birth, weight children.

PMID- 1023894
TI  - [Proprioceptive innervation of the oculo-extrinsic muscles of the calf].

PMID- 1023895
TI  - [Changed reflexes of vascular resistance in the hindlimb of the rabbit induced by
      the stimulation of chemoreceptors ( K and P) in the femoral circulation].

PMID- 1023896
TI  - [Effects induced by pharmacological blocks of the neurovegetative system on
      cardiovascular reflexes determined by the stimulation of chemoreceptors (K and P)
      in the femoral circulation].

PMID- 1023897
TI  - [Evaluation of cellular immunity using a skin test in chronic hepatitis and liver
      cirrhosis].

PMID- 1023898
TI  - [Cellular immunity in the aged as evaluated by a delayed hypersensitivity test in
      vivo (intradermal test and contact test)].

PMID- 1023899
TI  - [Evaluation of cellular immunity in man using skin tests (methods)].

PMID- 1023900
TI  - [Effect of ionic concentration of homogenization media on the re-distribution of
      poly A synthetase activity in dependence on Mn++ from soluble cytoplasmic and
      nuclear extracts of rat liver cells].

PMID- 1023901
TI  - [Different response of nuclear and cytoplasmic poly A synthetase of the rat liver
      on the additon of phosphate to the incubation media].

PMID- 1023902
TI  - [1st findings on glycocalices of epithelial cells in the colon under normal
      conditions and in subjects with ulcerative colitis].

PMID- 1023903
TI  - [Variation of the immune response in patients with cancer].

PMID- 1023904
TI  - [Pathology of osmoreceptors and neuropituitary dysfunction].

PMID- 1023905
TI  - [Partial purification and properties of 3-mercaptopyruvate sulfurtransferase in
      the bovine kidney].

PMID- 1023906
TI  - [Synthesis of seleno-homocystamine and seleno-homolanthionamine].

PMID- 1023907
TI  - [Changes in various enzyme activities in the rat organs after administration of 5
      HT and hyperbaric treatment at 3 ATA].

PMID- 1023908
TI  - [Electrophysiological study on the cerebello-pyramidal convergences of rad
      nucleus in the cat].

PMID- 1023909
TI  - [Studies on the absolute refractory period of pyramidal tract fibers in the cat].

PMID- 1023910
TI  - [Interaction between phenzaine-5-methylsulfate and sulfide].

PMID- 1023911
TI  - [Preparation of normal granulocyte concentrations].

PMID- 1023912
TI  - [Chromatin ultrastructure in CLL lymphocytes].

PMID- 1023913
TI  - [Chromosomal proteins during ontogenesis of Gallus gallus. I. Non-histone
      proteins in the liver].

PMID- 1023914
TI  - [Chromosomal proteins during ontogenesis of Gallus gallus. II. Non histone
      proteins in the brain].

PMID- 1023915
TI  - [Chromosomal proteins during ontogenesis of Gallus gallus. III. Non-histone
      proteins in the heart].

PMID- 1023916
TI  - [Characterization of proteases contained in the non-histone protein fraction of
      the chromatin in human lymphocytes].

PMID- 1023917
TI  - [Analysis of the DNA (F1+ F2b+ F3)--sphinogomyelin interaction].

PMID- 1023918
TI  - [Evaluation of optimal conditions for the determination of blood histamine using
      a fluorimetric method].

PMID- 1023919
TI  - [Effects of water loading on dopamine excretion in man].

PMID- 1023920
TI  - [Electrical impedance measurements in the human body: comparison between bipolar
      and tetrapolar systems].

PMID- 1023921
TI  - [Electrical impedance measurements in the human body: electrode characteristics].

PMID- 1023922
TI  - [Changes in the lung liporegulating function in subjects with chronic pulmonary
      emphysema].

PMID- 1023923
TI  - [Quantitative changes of blood components during the course of liver perfusion.
      1. Observations on non-oxygenating extracorporeal circulation].

PMID- 1023924
TI  - [Evaluation of various biochemical parameters during the course of liver
      perfusion at variable temperatures].

PMID- 1023925
TI  - [Dynamometric study on the musculo-skeletal efficiency in the frogmen].

PMID- 1023926
TI  - [Research for non-organ-specific autoantibodies in the serum of Au-positive
      subjects].

PMID- 1023927
TI  - [Functional morphology of the human trabecular corneo-scleral meshwork in normal
      conditions].

PMID- 1023928
TI  - [Determination of alimentary value of buffalo muscle proteins using enzymatic
      methods].

PMID- 1023929
TI  - [Evaluation of glycemia as a prognostic method in cranial injuries].

PMID- 1023930
TI  - [Morphological changes in the leukocytes of healthy persons in an hypotonic
      osmotic environment (preliminary report)].

PMID- 1023931
TI  - [Effects of dynamic and isometric exercise on the respiratory organ].

PMID- 1023932
TI  - [Behavior of heart rate and of arterial pressure during combined dynamic and
      isometric exercise].

PMID- 1023933
TI  - [Purification of concentrated anti-influenza vaccine using ultrasonic treatment
      and filtration with sterile filters].

PMID- 1023934
TI  - [Experimental studies on the autoregulation of regional pancreatic circulation.
      Effect of intramural peripheral venous stimulation. 4. Influence of atropine].

PMID- 1023935
TI  - [Experimental studies on the autoregulation of the regional pancreatic
      circulation. Effect of intramural peripheral venous stimulation. 5. Influence of
      sodium pentobarbital].

PMID- 1023936
TI  - [Experimental studies on the autoregulation of regional pancreatic circulation.
      Effect of intramural peripheral venous stimulation. 6. Influence of histamine].

PMID- 1023937
TI  - Cytomorphologic changes in the cerebrospinal fluid sediment; a comparative study
      by cytocentrifugation and cytosedimentation techniques.

PMID- 1023938
TI  - [Neurotrophic effect of various nerve-tissue subfractions on denervated muscles].

PMID- 1023939
TI  - [Morphological analysis of an interesting vascular variation in the structure of
      the portal vein in man].

PMID- 1023940
TI  - [Studies on basal gastrinemia and gastrinemia following protein stimulation
      during a course of treatment with chenodeoxycholic acid in normal subjects].

PMID- 1023941
TI  - [Effect of nerve-tissue subfractions on the development of pectoral muscles in
      the chick embryo].

PMID- 1023942
TI  - [Selective culture media for the isolation of yeasts from natural substrates].

PMID- 1023943
TI  - The action of the cerebral extracts of conditioned donors in the learning of
      avoidance responses.

PMID- 1023944
TI  - [Effect of ortho-phenylphenol on mitochondrial respiration].

PMID- 1023945
TI  - [Quantitative evaluation of the citric acid carrier in the mitochondrial
      membrane. - I].

PMID- 1023946
TI  - [Evaluation of the citric acid carrier in the mitochondrial membrane. II].

PMID- 1023947
TI  - [Proteins, ascorbic acid and malate dehydrogenase in the subretinal fluid from
      patients with retinal detachment].

PMID- 1023948
TI  - [RNA, polyamines and Mn++-dependent poly-A-synthetase activity in reserpinized
      and norepinephrine-treated heart].

PMID- 1023949
TI  - Porcine malignant hyperthemia IV: Neuromuscular blockade.
AB  - The effect of tubocurarine and pancuronium on the initiation or prevention of
      porcine malignant hyperthermia (MH) was investigated in Pietrain pigs.
      Tubocurarine 0.6 mg/kg body weight inhibited a suxamethonium-induced response in
      three pigs, but failed to prevent a fatal halothane-induced response in a further
      four pigs. Pancuronium 0.2 mg/kg body weight was given to six pigs before a
      halothane challenge. Three animals developed MH and died; the remainder succembed
      only after reversal of the neuromuscular blockade. The partial protection
      afforded by large doses of pancuronium is discussed in relation to the ability of
      previous muscle activity to influence the sensitivity to halothane.

PMID- 1023950
TI  - Pancuronium bromide: an indirect sympathomimetic agent.
AB  - In the dog, pancuronium 0.2 mg/kg increased left ventricular systolic pressure
      and systemic arterial pressure, but did not change central venous pressure.
      Repeated doses produced diminishing responses and eventually no change in
      arterial pressure. After tachyphylaxis was established, a pressor response to
      pancuronium could be induced by an i.v. infusion of noradrenaline. Desipramine, a
      noradrenaline blocking agent, prevented the restoration of the pressor effect of
      noradrenaline. Guanethidine and reserpine abollished the restoration of the
      pressor response to pancuronium by noradrenaline. These findings are consistent
      with the hypothesis that pancuronium acts on the postganglionic nerve endings and
      causes release of noradrenaline.

PMID- 1023951
TI  - A study of the effects of dexclamol as the neuroleptic component in
      neuroleptanaesthesia.
AB  - In a double-blind cross-over study in dogs, dexclamol was compared with
      droperidol as the neuroleptic component of a neuroleptanalgestic combination.
      Fentanyl was the narcotic analgessic. Neuroleptanaesthesia was induced with a
      mixture of the neuroleptic, the analgesic and nitrous oxide in oxygen. Dexclamol
      200 microng/kg i.v. was as effective as droperidol at the same dose in inducing
      neurolepsy and in supplementing nitrous oxide anaesthesia. Changes in heart rate,
      respiratory rate and rectal temperature in the animals treated with dexclamol
      were not different from those observed in the animals treated with droperidol. A
      comparison of the adrenolytic properties of dexclamol and droperidol was made on
      the isolated rabbit aortic strip. Both compunds produced a parallel shift to the
      right of the noradrenaline cumulative dose-response curves, indicating
      competitive antagonism. The pA2 values showed dexclamol to be approximately 15
      times less potent than droperidol in inhibiting the noradrenaline-induced
      contraction of the rabbit aortic strip.

PMID- 1023952
TI  - The effect of concentration on vasoactivity of bupivacaine and lignocaine.
AB  - In a double-blind trial bupivacaine 0.125, 0.25 and 0.5% and lignocaine 0.5, 1
      and 2% were given intradermally to 31 volunteers. Vasoconstriction was observed
      more frequently at low concentrations of each drug, and vasodilatation at high
      concentrations. These observations were highly significant (P less than 0.001).
      Duration of action was unaffected by concentration, except in the case of
      bupivacaine 0.5%, the effect of which was longer lasting than that of other
      solutions.

PMID- 1023953
TI  - The influence of three antacids on the absorption and clinical action of oral
      diazepam.
AB  - Diazepam 10 mg given orally alone or with one of the three antacids (aluminium
      hydroxide 40 ml, magnesium trislicate 30 ml, sodium cirate 30 ml) was given in a
      single dose at random to 200 women undergoing minor gynaecological procedures.
      The concomitant use of aluminium hydroxide or sodium citrate hastened the onset
      of the soporific effect of diazepam marginally, while magnesium trisilicate
      tended to delay it. The estimation of plasma diazepam concentrations over 90 min
      in a similar series of 67 patients showed that the absorption of diazepam was
      increased significantly by the use of aluminium hydroxide, but there were no
      striking differences in the four groups. The clinical implications of these
      findings are discussed.

PMID- 1023954
TI  - Some pharmacological factors influencing the absorption of diazepam following
      oral administration.
AB  - Plasma diazepam concentrations were measured by gas-liquid chromatography in
      samples of blood from adult female patients follwing diazepam 10 mg orally, alone
      or in combination with metoclopramide, morphine, pethidine or atropine. Patients
      receiving metoclopramide had higher plasma diazepam concentrations than those in
      the control group, while the addition of morphine, pethidine or atropine resulted
      in lower plasma diazepam concentrations throughout the 90-min period of the
      study. In the control goup peak plasma concentrations were reached by 60 min. The
      addition of metoclopramide increased the rate of diazepam absorption and peak
      concentrations were reached by 30 min, while morphine, pethidine and atropine
      reduced the rate of absorption with no apparent peak being reached by 90 min.

PMID- 1023955
TI  - Reactions to intravenous injections of diazepam.
AB  - Local reactions during and after i.v. injection of two different formulations of
      diazepam were studied. Two-thirds of the patients felt pain during the injection.
      Verfied or probable thrombophlebitis occurred with increasing frequency following
      operation, indicating a late onset. One month after discharge, 29% of those who
      had received diazepam in glycoferol-alcohol-benzoic acid complained of tender
      injection sites, compared with only 10% of the patients who received diazepam in
      cremophor EL. The difference is significant, indicating an influence of the
      solvent system.

PMID- 1023956
TI  - Anaesthesia and the reticulo-endothelial system: Comparison of halothane-nitrous
      oxide and neuroleptanalgesia.
AB  - The effect of halothane anaesthesia and neuroleptanalgesia (NLA) on the
      phagocytic activity of the reticulo-endothelial system (RES) was investigated
      with the aid of the Lipofundin clearance test. The results suggest that halothane
      in nitrous oxide depresses the phagocytic activity of the RES. NLA did not exert
      a depressant effect on the RES function. As it is essential for the body to be in
      a defensive condition to cope adequately with infensive condition to cope
      adequately with infection and cancer metastases, care must be taken to ensure
      that an anaesthetic procedure does not cause additional impairment of RES
      function. The results of the investigations suggest that NLA may have advantages
      in this respect.

PMID- 1023957
TI  - The influence of doxapram on postoperative pulmonary function in patients
      undergoing upper abdominal surgery.
AB  - An infusion of doxapram 250 mg in dextrose 5% compared with dextrose 5% alone in
      patients recovering from upper abdominal surgery was associated with a reduction
      in the degree of hypoxaemia after operation. This may be the result of a sparing
      effect on the functional residual capacity.

PMID- 1023958
TI  - Intraocular pressures after suxamethonium and endotracheal intubation in patients
      pretreated with pancuronium.
AB  - Intraocular pressures were recorded after the administration of suxamethonium and
      endotracheal intubation in a series of 20 patients who had not received
      pancuronium 1 mg 4 min before the suxamethonium. The pressures were compared with
      those in a control group of 20 patients who had not received pancuronium. The
      increase in intraocular pressure which followed the suxamethonium and intubation,
      and which occurred in about 50% of the patients, was similar in both groups of
      patients.

PMID- 1023959
TI  - A comparison of the incidence of cardiac arrhythmia during two methods of
      anaesthesia for dental extractions.
AB  - One hundred premedicated inpatients undergoing wisdom tooth extraction were
      divided into two groups of 50. Group A was anesthetized by a technique based on
      droperidol and phenoperidine, whilst group B was anaesthetized with halothane.
      The e.c.g. in both groups demonstrated a similar overall incidence of cardiac
      arrhythmia, but analysis revealed a significantly higher incidence of ventricular
      arrhythmia in group B. The heart rate was significantly less in group A.

PMID- 1023960
TI  - Screen test for patients.

PMID- 1023961
TI  - Electronics and emergency medicine: speeding help to the patient via telemetry
      and telephone.

PMID- 1023962
TI  - [Kinetics of corneal fluorescence in experimental keratitis].
AB  - It was shown by the method of scanning photometry suggested by the authors that
      rabbits with experimentally-induced keratitis displayed a three-phasic reaction
      of the area of the corneal burn: that of the enhanced fluorescein sorption at the
      reactive phase: that of the loss of the sorption capacity in the dystrophic
      stage, and that of the secondary absorption intensification during the
      regenerative stage. The mentioned phasic changes can be used for the diagnosis
      and objective assessment of the clinical course of keratitis.

PMID- 1023963
TI  - [Microcirculatory changes in the cheek pouch mucosa of hamsters in the dynamics
      of experimental traumatic shock].
AB  - Acute experiments conducted on hamsters demonstrated significant disturbances of
      the microcirculation in the mucosa of the cheek pouch during a severe traumatic
      shock after a standardized mechanical injury of the hip. All the animals died in
      the course of the first 24 hours after this trauma. If the animals died not
      earlier than in one hour after the trauma the microcirculation changes were
      distinctly phasic in character; particularly there was seen a phase of temporary
      relative adaptation and stabilization of the peripheral circulation, invariably
      followed by the phase of decompensation, the terminal phase and death. In cases
      with a rapid lethal issue in the course of one hour no distinct phasic character
      of the microcirculation changes was observed, but there was a more or less rapid
      aggravation of all he indices. In difference from the majority of other
      investigators, no marked intravascular erythrocyte aggregation was seen by the
      authors in the experiments described.

PMID- 1023964
TI  - [Dynamics of the mass of the right ventricle of the heart and concentration of
      RNA in it during the process of "reverse" development of hypertrophy].
AB  - Experiments were conducted on male rats, 250-300 g in weight. Adaptation to high
      altitude hypoxia was created by placing the animals daily for 5 hours, into an
      altitude chamber, at an "altitude" of 6000 m. The degree of hypertrophy of the
      right ventricle and its RNA content was studied after 20 days of adaptation, as
      well as 2, 10, 20 and 40 days after cessation of hypoxia. Twenty days after the
      beginning of adaptation the muscle mass of the right ventricle the RNA
      concentration and amount in it was found to increase considerably. After
      cessation of hypoxia half of the acquired increase in the ventricle muscle mass
      was lost in 10 days, and half of the acquired increase in the RNA--as soon as in
      2 days. Forty days after cessation of hypoxia the right ventricle mass and its
      RNA content in the adapted animals did not differ from the same indices in
      control rats.

PMID- 1023965
TI  - [Effect of the procedure of blood exchange on several indices of skeletal muscle
      metabolism].
AB  - In 85% blood exchange in healthy dogs and also in the animals under conditions of
      hemotransfusion shock a study was made of the nitrogen fraction contents, the
      activity of aspartic and alanine transpherases in the skeletal muscle in the
      course of 7 days. Blood exchange in hemotransfusion shock was highly effective.
      However, the process of "washing out" of the non-protein substances from the
      tissue in these animals was considerably lowered in comparison with that in
      healthy animals.

PMID- 1023966
TI  - [Bone marrow colony-forming capacity in mice subjected to burn trauma].
AB  - A method of exogenous splenic colonies was applied to the study of the dynamics
      of the content of the colony-forming units (CFU) in the bone marrow of CBA mice
      to which thermal burn of the III degree of 15% of the body surface was inflicted.
      On the 4th and 16th days after the burn the CFU content in the bone marrow of
      mice decreased 1.7-2.1 times. The thymus cells of the intact mice administered
      simultaneously with the bone marrow of the burned mice increased, the amount of
      the splenic exogenous colonies formed in the recipients. The data obtained
      permitted to make a suggestion that not only the CFU count diminished in the bone
      marrow in the burned animals, but also the thymus-dependent cells necessary for
      normal colony formation.

PMID- 1023967
TI  - [Interaction of connective tissue structural glycoprotein with proteoglycans and
      glycosaminoglycans].
AB  - It was shown that structural glycoprotein (SGP) of connective tissue isolated
      from be cattle heart valves and nasal septum cartilage formed water-soluble
      complexes with protein-chondroitin-4-sulphate and different heparin fractions.
      SGP formed no mentioned complexes with hyaluronic acid. Probably this plays an
      important role in the formation of collagen and elastin fibers.

PMID- 1023968
TI  - [Adrenocortical regulation of protein metabolism during prolonged physical
      stress].
AB  - Experiments on Wistar male rats revealed depression of labeled amino acid
      incorporation into the tissue proteins as a result of swimming. When prolonged
      swimming was accompanied by an enhanced adrenocortical activity the block of the
      protein synthesis in the liver proved to disappear. Adrenalectomy excluded the
      activation of alanine-aminotranspherase and a drop of the free amino acids in the
      liver during physical exercise: corticosterone administration to adrenalectomized
      animals restored these shifts.

PMID- 1023969
TI  - [Effect of sodium succinate on several carbohydrate metabolism indices of
      ischemic myocardium].
AB  - The influence of sodium succinate on the content of lactic, pyruvic acids and
      glucose in the venous blood flowing from the ischemic zone of the myocardium was
      studied in dogs with ligated coronary artery. The intracoronary injection of the
      preparation in doses of 2 and 10 mg/kg diminished the content of blood lactic
      acid flowing from the ischemic zone; a dose of 10 mg/kg decreased the consumption
      of glucose by the ischemic myocardium. Sodium succinate (100 mg/kg) intravenously
      reduced the content of the lactic acid significantly and inhibited the glucose
      consumption by the ischemic myocardium, with its increase in the arterial blood.
      A fall of lactacidemia can be connected with the activation of Krebs cycle and an
      increase of oxygen utilization by the ischemic myocardium.

PMID- 1023970
TI  - [Relationship between tryptophan metabolism and the state of melaninogensis].
AB  - In studying the excretion of tryptophan and the activity of tryptophan pyrrholase
      of the liver in black and albino rabbits it was revealed that the kinurenine,
      kinurenic and xanthurenic acids, 3-hydroxykinurenin, anthranylic acid and 5
      hydroxyindolylactic acid levels in the urine collected before the L-tryptophane
      loading differed in these animals. No 3-hydroxyanthranylic acid was found in the
      initial urine of these rabbits. A sharp intensification of excretion of all the
      tryptophane metabolites studied followed the administration of L-tryptophane to
      albino rabbits, and a harper elevation of kinurenic and xanthurenic acid
      excretion--to black rabbits. In comparison with black rabbits, the tryptophan
      pyrrholase of the liver of albino rabbits reached to the L-tryptophan
      administration more intensively.

PMID- 1023971
TI  - [Toxicity and proteolysis in gnotobiotic rats with thermal burns].
AB  - Experiments were conducted on germ-free (gnotobiotic) rats. A study was made of
      the toxic properties of the organs and the activity of proteolytic enzymes in
      them after thermal burns. Despite the absence of pathogenic microbial flora the
      germ-free rats developed the state of toxemia with an increase of the level of
      proteolytic enzymes. The extent of the toxic and catabolic reaction depended on
      the severity of the burn. Intoxication and an increase in proteolysis in the
      gnotobiotic rats were similar, and, in a number of cases greater than in usual
      animals. A conclusion was drawn on the important role of the tissue sources of
      intoxication in burns. A correlation between the toxemia and proteolysis was
      established.

PMID- 1023972
TI  - [Increase in the sensitivity of rabbit sensomotor cortex neurons to gamma
      aminobutyric acid under the influence of diazepam (microiontophoretic study)].
AB  - A study was made of the action of diazepam on the effects of the gamma
      aminobutyric acid (GABA) applied electrophoretically to the neurons of the
      sensory-motor rabbit cortex. It was shown that diazepam intensified the
      depressive action of GABA on the spontaneous neuronal activity and the prolonging
      action of GABA on the duration of the inhibitory phase in the neuron responses to
      the afferent and direct stimulation of the cortex. Diazepam failed to alter the
      neuron response to glycine, glutamate and acetylcholine applied
      microelectrophoretically. It is supposed that diazepam increased the sensitivity
      of the receptors of the post-synaptic membrane of the neuron to GABA.

PMID- 1023973
TI  - [Role of surface phenomena in the mechanism of action of antiarrhythmic
      substances].
AB  - The surface activity of the antiaarhythmic drugs and their influence on the lipid
      containing interphasics were studied. It was found that drug No. 7351 (diphenyl
      isopropyl acetic acid diethyl aminopropyl ester), fubromegan, metamysil,
      propranolol, quinidine, novocalinamide, xylocaine, and trimecaine possessed
      surface activity. There exists a symbate relationship between the surface and
      especially the interphasic activity and the antiarrhythmic effect. The most
      active antiarrhythmic drug No. 7351 increased the electric conductivity of the
      lecithine bilayer membrane much more than novocainamide.

PMID- 1023974
TI  - [Distribution of the adrenoblocking drug pyrroxan in the bodies of white rats].
AB  - The distribution of adrenoblocking drug pyrroxan in the blood plasma and
      different organs of albino rats had been studied. A rapid appearance of pyrroxan
      in the brain liver, kidneys, and other organs was shown; its selective
      accumulation in the hypothalamus was found. As revealed spectrofluorimetrically
      unchanged pyrroxan molecules disappeared from the plasma and the organs within 2
      hours. When pyrroxan-14C was used the radioactivity in the organs was
      demonstrated for 24 hours, and in the plasma for several days; this indicated the
      formation of pyrroxan metabolites or its complexes with the plasma proteins and
      structural elements of the organs. The selective accumulation of pyrroxan in the
      hypothalamus can account for the high efficacy of this drug in different
      hypothalamic disorders coursing with the overexcitation of the sympathetic
      nervous system.

PMID- 1023975
TI  - [Stimulant effect of antilymphocytic serum on early stages of hematopoietic
      recovery in the spleen of radiation chimeras].
AB  - Experiments conducted on 236 BALB/c mice were aimed at the study of the effect of
      the antilymphocytic serum on the hemopoiesis recovery in the spleen of the
      radiation chimeras, since the antilymphocytic serum was known to increase the
      number of macroscopic hemopoietic colonies. This increase was found to be due to
      the intensification of the first hemopoietic recovery stage, i.e. to the
      acceleration and intensification of the reticular cell activation in the
      recepient's spleen.

PMID- 1023976
TI  - [Increase in the sensitivity of leukemia cells, incubated in interferon, to the
      effect of immune serum].
AB  - L-1210 AND P-388 leukemic cells were incubated in three types of interferon, i.e.
      L-cell interferon and two types of lymphocyte interferon (induced in the lymph
      node lymphocytes of intact mice and the lymphocytes obtained on the 10th day
      after intraperitoneal injections of 5-10(7) L-1210 cells). "False" interferon
      obtained by the method analogous to that of obtaining L-cell interferon,
      excluding the viral induction, was used for control. Cells incubated in
      interferon proved to be more sensitive to the action of the cytotoxic antibodies
      than those treated with "false" interferon. Treatment of the cells with
      lymphocytic interferon induced on the lymphocytes of immune mice increased their
      sensitivity even more in comparison with the cells treated with interferon
      obtained from intact mice.

PMID- 1023977
TI  - [Drug-induced immune tolerance to sheep erythrocytes in mice of different lines].
AB  - Immunological tolerance to sheep erythrocytes was induced in mice of the CBA,
      C57BL/6, CC57BR, C3H, DBA/2 lines by means of combined administration of a high
      dose of the antigen and cyclophosphamide. The count of 19S antibody-forming cells
      was determined in the mouse spleen after the test injection of erythrocytes, by
      local hemolysis in gel. The extent of the tolerance induced proved to depend on
      the genotype of the animals; mice of the DBA/2 line were found to be most
      "sensitive" to its induction. There was revealed no correlation between the level
      of the immunological reactivity to sheep erythrocytes in the intact mice of
      different lines and the extent of its suppression in tolerance induction

PMID- 1023978
TI  - [Lethal infection with BCG in thymectomized mice].
AB  - Investigations carried out on CBA mice demonstrated that adult mice to which
      mycobacteria BCG were injected intravenously 12 months after thymectomy (in a
      dose of 2 mg for a period of 2 1/2 months) died of disseminated BCG infection
      against the background of depression of hypersensitivity of delayed type. The
      usual vaccine process developed in the sham-operated animals.

PMID- 1023979
TI  - [Influence of the serum globulins of persons differing in the ABO system on
      allergic responses of the immediate type].
AB  - The antianaphylactic effect of globulins obtained from human sera of different
      blood groups of the ABO system on the active and passive anaphylaxis of guinea
      pigs, and on mast cells destruction was studied. A marked inhibitory action of
      globulins obtained from human serum of the B (111) blood group on the allergic
      reactions of the immediate type was shown. Globulins from the 0 (1) group did not
      possess such action.

PMID- 1023980
TI  - [Dissemination of carcinogenic H3-dialkylhydrazines in the neuro-endocrine system
      and their antigonadotropic effect in rats].
AB  - Three hours after the dimethylhydrazine-3H (DMH) treatment specific radioactivity
      in the male rat pituitary, adrenal cortex, and the testes was higher than in the
      liver by 53, 85, and 108%, respectively. Tritium incorporation into the
      hypothalamus was higher than that by the liver, cerebral cortex, and the brain
      stem by 33, 69, and 44%, respectively. Three hours after the diethyl-hydrazine-3H
      (DEH) treatment the specific activities of the pituitary and the testes in male
      rats were higher than that of the liver by 57 and 108%, respectively. A single
      DMH and DEH administration to male rats in a dose of 21 mg per kg body weight
      resulted in a significant decrease of the pituitary FSH level (by 63 and 53%,
      respectively). The data obtained were indicative of a marked influence of the
      carcinogenic dialkylhydrazines on the rat neuroendocrin system.

PMID- 1023981
TI  - [Role of destruction products of tissue macrophages in regulating
      granulocytopoiesis].
AB  - Peripheral blood leukocytosis and an increase of mature forms of neutrophils and
      monocytes in the bone marrow, as well as an improvement of the oxygen supply of
      the bone marrow cells (by the data of polarographic studies) followed the
      intraperitoneal injections of rat peritoneal macrophage destruction products
      (MDP) to the recipient rats. Analogous changes were obtained in the bone marrow
      in case of intraperitoneal injection of the cytotoxic quartz dust particles.
      Having been injected intraperitoneally to donor CBA mice, the MDPs strikingly
      stimulated the glanulocytopoietic colonies formation in the spleen of the
      recipient CBA mice X-irradiated with a lethal dose and then injected
      intravenously with the bone marrow of spleen tissue suspensions obtained from the
      donors. The results obtained are discussed from the aspect of a possible role of
      the destroyed tissue macrophages in the formation of a colony-stimulating factor
      in the auto-control of the phagocytic responses.

PMID- 1023982
TI  - [Effect of overheating on spermatogenesis in mice and the value of heat training
      in adapting sex cells to the effects of high temperatures].
AB  - A single, 10-minute, stay of albino mature mice in a thermochamber at a
      temperature of 43 degrees C and a relative humidity of 65% caused destruction of
      the spermatogenic epithelium expressed in degeneration and desquamation of the
      sexual cells in 55% of the seminiferous tubules. Preliminary 10-day thermal
      training caused only an intensification of the physiological degeneration of the
      spermatogenic cells in 16% of the seminiferous tubules; this could point to the
      adaptation of the sex cells to the action of the high temperature.

PMID- 1023983
TI  - [Myoglobin concentration and the state of myocardial organelles following
      myocardial infarction].
AB  - A study was made of the quantitative changes in myoglobin and the subcellular
      organization of the myocardium at early periods of experimental infarction of the
      heart in dogs. There proved to be a correlative relationship between the
      myoglobin content and the state of subcellular organization of the cardiomyocytes
      in the ischemic area and the so-called intact portions of the right and the left
      ventricles.

PMID- 1023984
TI  - [Myocardial ultrastructure in the presence of assisted circulation].
AB  - Experiments were conducted on dogs; a study was made of the influence of a method
      of assisted circulation--contrapulsation, on the myocardial ultrastructure. A
      sharp glycogen accumulation in the muscle cells of the heart, the presence of
      mitochondria with a marked osmophilic microgranular matrix, and also a high
      pinocytic activity of the capillary endothelial cells were revealed by electron
      microscopy. The data obtained pointed to the metabolic reconstruction in the
      myocardium, and primarily to the reduction of the energy level of the myocardial
      muscle cell function. The changes in the myocardial ultrastructure revealed
      apparently provided the positive therapeutic effect.

PMID- 1023985
TI  - [Histopathology of the dentomaxillary system in experimental fluorosis].
AB  - Dynamics of experimental dental fluorosis and regress of the process were studied
      on albino rats. Fluorine produced a selective toxic action on the tissues of the
      permanently growing incisors causing disturbances of the dentine- and
      amelogenesis, and also derangement of the pulp circulation. Changes in the bone
      tissue of the jaws were characterized by the progressive porosity phenomena. It
      appeared that regress of the process required a definite duration of the
      restorative period.

PMID- 1023986
TI  - "We the People...a unique heritage for institutional ministry".

PMID- 1023987
TI  - The formation and function of a quality of life committee.

PMID- 1023988
TI  - Should hospitals be regulated as utilities?

PMID- 1023989
TI  - A Samaritan's struggle for humane and religious care.

PMID- 1023990
TI  - The hidden benefits of required planning.

PMID- 1023991
TI  - Specialty distribution of physicians: congressional statement.

PMID- 1023992
TI  - Executive vice president's rounds.

PMID- 1023993
TI  - Schizophrenia & rehabilitation.

PMID- 1023994
TI  - The effect of foster home placement on psychiatric patients; observed changes and
      contributory factors.

PMID- 1023995
TI  - Interdisciplinary workshop recommendations regarding the community placement of
      psychiatric patients.

PMID- 1023996
TI  - A study of placement of the psychiatric patient.

PMID- 1023997
TI  - Community care services in Vancouver: initial planning and implementation.

PMID- 1023998
TI  - Coast Foundation Apartment Project.

PMID- 1023999
TI  - Options for treatment of the schizophrenic patient.

PMID- 1024000
TI  - Whither approved homes? An analytical-descriptive study of the Parkland Region
      Approved Home Program.

PMID- 1024001
TI  - The semi-community environment and the reintegration of the psychiatric resident:
      present status and outlook for the future.

PMID- 1024003
TI  - Care, not treatment. A personal view from the U.S.

PMID- 1024002
TI  - Mental Health/Ottawa's Group Homes Project.

PMID- 1024004
TI  - The AFCR--administrative ischemia.

PMID- 1024005
TI  - Specialization as scientific advancement and overspecialization as social
      distortion.

PMID- 1024006
TI  - Legislation and the future of medical specialization.

PMID- 1024007
TI  - Internal medicine and the functions of the generalist: some notes on a new
      synergy.

PMID- 1024008
TI  - The primary care problem.

PMID- 1024009
TI  - Ethical issues regarding case reports: to publish or perish the thought.

PMID- 1024010
TI  - Psychosis. A poem written at the moment psychosis was burning out.

PMID- 1024011
TI  - [Psychotherapeutic function of the South American medicine man].
AB  - Observing the medicine man system in South America from a psychological point of
      view, the function of the medicine man can be characterized as psychohygienic or
      psychotherapeutic; that is to say he employs many methods similar to modern
      psychotherapeutic ones. We know from many ethnological field research reports
      that the medicine man employs in his healing procedures - among other things -
      dream interpretation, (auto-) hynosis, and healing suggestion, advises the sick,
      uses imaginative techniques, and initiates group catharsis, i.e. he treats his
      patients by psychological means. The psychic disturbances which he treats concern
      less the individual but much more often the whole group. Here the medicine man
      must work as a regulator and valve for the group and try to equalize, to prevent
      and to heal all disturbances within the collective.

PMID- 1024012
TI  - [Irony and cynicism as forms of defense].
AB  - Irony and Cynicism are understood to be defense mechanisms. The principle of
      opposites explains Irony best:  it serves the purpose of avoiding the negative
      affect of a state by maintaining its dialectic opposite. Irony can thus be
      attributed to counter-cathexis. Cynicism has already been shown in its historical
      development to be a form of denial with the purpose to minimize the importance of
      the object. Sarcasm is not a defense but a form of aggressive discharge.

PMID- 1024013
TI  - Mechanisms for developing pharmaceutical services.

PMID- 1024014
TI  - The pharmacist's role in the management of hypertension.

PMID- 1024015
TI  - Unit-dose in a 592-bed hospital.

PMID- 1024016
TI  - The crunch cometh.

PMID- 1024017
TI  - Productivity and motivation.

PMID- 1024019
TI  - The human side of management.

PMID- 1024018
TI  - The design and implementation of a unit-dose system.

PMID- 1024020
TI  - Drug therapy--governmental concerns.

PMID- 1024021
TI  - Preventive pharmacy care.

PMID- 1024022
TI  - The unit-dose study.

PMID- 1024023
TI  - A study of unit-dose drug distribution in four Canadian hospitals.

PMID- 1024024
TI  - Proposed selective immunization of Canadians against A/Swine strain of influenza.

PMID- 1024025
TI  - Continuity with change. 1976 Lilly lecture.

PMID- 1024026
TI  - Review of combinations of antiasthmatic drugs by Saskatchewan Drug Quality
      Assessment Committee.

PMID- 1024027
TI  - Guidelines--drug monitoring in the Canadian hospital.

PMID- 1024028
TI  - [Results, after 21 years, of a thrombectomy for ilio-femoral phlebitis. Clinical,
      phlebographic and ultrasound data].

PMID- 1024029
TI  - [Late cardiopulmonary consequences of thoracic transposition of the spleen].

PMID- 1024030
TI  - [Recent acromio-clavicular dislocations].

PMID- 1024031
TI  - [Residual common bile duct stone. Apparent recovery after treatment with
      chenodesoxycholic acid].

PMID- 1024032
TI  - [Latero-cervical nerve tumors. Apropos of 19 cases].

PMID- 1024033
TI  - [Localizations of Dupuytren's contracture in the radial part of the hand].

PMID- 1024034
TI  - [Adrenal cysts and pseudocysts. Apropos of 3 cases].

PMID- 1024035
TI  - [Examination of the microfluctuations of the air sound flow as a function of
      various modalities of vocal emission].

PMID- 1024036
TI  - A female case of Kallmann's syndrome.
AB  - A case of 20-year-old woman with hypogonadotropic hypogonadism and anosmia is
      reported, since very few female cases of Kallmann's syndrome have been reported
      so far in Japan. Three uncles on the father's side had no children. Height was
      168 cm, and arm span 165 cm. The olfactory test revealed complete anosmia. Bone
      age was 13 year. Chromosome was 46 XX and normal karyotype. Basal levels of serum
      FSH, LH and estrogens (E1, E2 and E3) were low. Serum FSH and LH levels rose
      slightly only after LH-RH administration, and did not increase in clomiphene
      test. Plasma estrogens did not increase after daily injection of 150 IU of HMG
      for 3 successive days. The response of serum GH to arginine infusion was normal,
      while that to insulin-induced hypoglycemia was poor.

PMID- 1024037
TI  - A transient increase in renal clearance of phosphate in response to continuous
      infusion of salmon calcitonin in rats.
AB  - The effects of intravenous carrier-free salmon calcitonin on renal clearances of
      phosphate, calcium, magnesium, sodium and potassium were studied in male
      parathyroid-ectomized (PTX) and intact rats. Both natural and synthetic hormone,
      when infused at constant rates (0.005 approximately 0.5 MRC U/hr), produced a
      rapid increase (peaking at about 60-90 min) in phosphate clearance. However, the
      maximal increase was transient in nature in PTX rats. In intact rats, the
      phosphaturic response was somewhat more pronounced and the decline after the peak
      was rather modest. When a large amount (4 MRC U) of calcitonin was given in
      divided doses, the second dose produced a lesser extent of phosphaturia in both
      intact and PTX rats. The phosphaturic response was accompanied by an increase in
      sodium and potassium clearances in PTX rats and by an increase in potassium
      clearance in intact rats. A fall in the apparent clearance values for calcium and
      magnesium occurred and was maintained throughout the infusion period of hormone
      in both intact and PTX rats. In conclusion, PTX rats respond to the intravenous
      administration of salmon calcitonin with a transient phosphaturic response which
      is accompanied by parallel diuresis of sodium and potassium along with sustained
      retention of calcium and magnesium by the kidney.

PMID- 1024038
TI  - Occurrence of permanent changes in vaginal and uterine epithelia in mice treated
      neonatally with progestin, estrogen and aromatizable or non-aromatizable
      androgens.
AB  - Female mice of the C57 Black/Tw strain were injected daily with 100 microng
      testosterone, 50 microng testosterone propionate (TP), 100 microng 5 alpha
      dihydrotestosterone (DHT) or 50 microng 5 alpha-dihydrotestosterone propionate
      (DHTP), for 10 days from the day of birth. Two other groups of female mice were
      given neonatal injections with 20 microng estradiol-17 beta and 100 microng
      progesterone for 10 days, respectively. All mice were ovariectomized at 60 days
      of age and killed at 90 days. In 100% of neonatally estrogenized or androgenized,
      ovariectomized mice, the cranial part of the vagina was lined with stratified
      epithelium with either cornification or parakeratosis or mucification.
      Stratification only or stratification with superficial squamous metaplasia or
      cornification took place in the uterine epithelia of 18% of the TP-treated, 75%
      of the DHT-treated and 50% of the DHTP-treated, ovariectomized mice. In contrast,
      neonatally estrogenized, ovariectomized mice did not show the estrogen
      independent, persistent uterine changes. Neonatal progesterone treatment failed
      to induce the permanent changes in the vaginal and uterine epithelia.

PMID- 1024039
TI  - Development of the vaginal epithelium showing estrogen-independent proliferation
      and cornification in neonatally androgenized mice.
AB  - Female mice of the C57 Black/Tw strain given 5 daily injections with 100 microng
      testosterone (T) or 5 alpha-dihydrotestosterone (DHT) from the day of birth
      showed estrogen-independent persistent proliferation and cornification of the
      vaginal epithelium in adulthood. The vaginal epithelium of the mice was
      essentially similar to that of the controls in histological structure during or
      shortly after neonatal injections of the androgens. In T- and DHT-mice aged over
      20 days, however, a marked proliferation with or without superficial
      cornification took place in the epithelium lining the proximal and middle parts
      of the vagina (Mullerian vagina), while neither proliferation nor cornification
      occurred in the epithelium of the distal vagina (urogenital sinus vagina). On the
      second day of postnatal life in mice given a single injection with T on the day
      of birth, the mitotic activity in the epithelium of the middle vagina was
      heightened, but it dropped to the control level on the third day and remained low
      until 20 days. By contrast, the mitotic rates in the epithelium of the rest of
      the vagina in T-mice and of all parts of the vagina in DHT-mice were
      approximately the same as in the controls until 20 or 30 days. The mitotic rates
      in the epithelium of the Mullerian vagina were markedly elevated in T-mice at 20
      days of age and DHT-mice at 30 days, and thereafter remained almost unchanged
      until 60 days of age. These results were different from the findings in mice
      given neonatal injections with the dose of estradiol-17 beta (E) capable of
      estrogen-independent vaginal cornification (Iguchi et al., 1976). The present
      finding seem to indicate that the mechanism involved in the induction of estrogen
      independent vaginal changes by neonatal administration of androgen (T, DHT) is
      different from that following neonatal treatment with estrogen (E), although
      androgen and estrogen act directly on the vaginal epithelium of neonates.

PMID- 1024040
TI  - Ultrastructural characteristics of the vaginal epithelium of neonatally
      estrogenized mice in response to subsequent estrogen treatment.
AB  - Adult mice which had received 10 daily injections of 20 microng estradiol
      beginning with the day of birth were in a "persistent-estrous" state, showing
      ovary-independent proliferation and cornification of the vaginal epithelium.
      Ultrastructural changes of the vaginal epithelium in neonatally estrogenized mice
      was examined after a single postpuberal injection of 10 microng estradiol and
      compared with those seen in normal mice to estrogen. In ovariectomized normal
      mice, the basal cells were round. The nucleus was polygonal and contained
      peripheral condensed chromatin. After estradiol treatment, the basal cells became
      columnar. The nucleus was round to oval, containing dispersed chromatin. In
      neonatally estrogenized ovariectomized mice, the basal layer of vaginal
      epithelium consisted of round cells with polygonal nuclei, much as in normal
      ovariectomized mice. The nucleus occupied a large area of the cytoplasm and
      contained prominent nucleoli. Intercellular spaces were moderately distended.
      Late estradiol treatment resulted in distended intercellular spaces and in the
      appearance of the other cell type along with round cells in the basal layers: the
      columnar cells containing an oval nucleus with dispersed chromatin, resembled the
      basal cells in normal ovariectomized mice receiving postpuberal estrogen
      injection. The intercellular spaces between the columnar cells were narrow
      compared with those between round cells. However, the nuclei of round cells still
      had prominent nucleoli and peripheral condensed chromatin regardless of
      subsequent estrogen treatment. This fact suggests that these nuclei do not
      respond to estrogen. These results clearly show that the vaginal epithelium of
      neonatally estrogenized mice with ovary-independent persistent cornification
      consists of a mixed population of cells.

PMID- 1024041
TI  - Clinical study on early changes in thyroid function of hyperthyroidism treated
      with propylthiouracil and a relatively small dose of iodide.
AB  - In order to compare the acute effects of three kinds of antithyroid agents of
      iodide (I-), propylthiouracil (PTU) and PTU combined with iodide (PTU+I-) on
      thyroid function in hyperthyroid patients with diffuse goiter, serum
      concentrations of thyroxine (T4), triiodothyronine (T3), T3-resin sponge uptake
      (T3-RU) and free thyroxine index (FT4I) were employed as thyroid function
      parameters. In the group given iodine (1 mg/day) as iodinated-lecithine, the
      initial values of T4, T3, T3-RU and FT4I were 20.9 +/- 1.6 microng/100 ml (T4),
      greater than 740 ng/100 ml (T3), 49.5 +/- 2.3% (T3-RU) and 14.7 +/- 1.8 (FT4I).
      At the end of one week of therapy, they decreased clearly to 15.6 +/- 2.2
      microng/100 ml, 457 +/- 87 ng/100 ml, 42.2 +/- 4.0% and 9.7 +/- 2.4. The so
      called "escape phenomenon" from iodide inhibition was observed in serum T4, T3-RU
      and FT4I values at the end of two weeks of iodide therapy, while serum T3
      continued to decrease but the value of T3 was far outside of the normal range. In
      the PTU group (300 mg/day), thyroid function parameters were 22.5 +/- 0.8
      microng/100 ml (T4), greater than 592 ng/100 ml (T3), 54.9 +/- 1.0% (T3-RU) and
      18.7 +/- 1.0 (FT4I) before treatment. They decreased continually week by week. At
      the end of four-week treatment with PTU, the value of each thyroid function
      parameter was 11.1 +/- 1.9 microng/100 ml, 229 +/- 56 ng/100 ml, 36.6 +/- 4.4%
      and 5.7 +/- 1.7. In the group of hyperthyroidism simultaneously given both PTU
      and iodide (300 mg/PTU and 1 mg/iodine), these thyroid function parameters
      decreased as well as in the group treated with PTU alone for more than two weeks.
      More rapid or significant decrease of T4, T3, T3-RU and ft4i in PTU+I- group than
      in PTU group was observed in the present study. These results suggested strongly
      that iodide alone was not an adequate therapy for hyperthyroidism as well known
      and they were also compatible with the idea that the concomitant administration
      of PTU and iodide was more effective in the early phase of therapy of
      hyperthyroidism than PTU alone.

PMID- 1024042
TI  - Radioimmunoassay for 11-deoxycortisol using iodine-labeled tracer.
AB  - A simple and sensitive radioimmunoassay for 11-deoxycortisol was developed. The
      antiserum produced in rabbits by immunizing with a complex of 11-deoxycortisol-3
      oxime and bovine serum albumin (BSA) has little cross-reactivity with other
      endogenous steroids. The immunoassay procedure requires only one-step ethanol
      denaturation of binding proteins in plasma and extraction by an organic solvent
      can be omitted. Furthermore, use of 125I-labeled tracer significantly simplify
      the counting procedure. The method is sensitive enough to detect 1 microng/100 ml
      of 11-deoxycortisol. Plasma 11-deoxycortisol levels measured by this method after
      the administration of a single dose of metyrapone ranged from 5.0 to 19.2
      microng/100 ml, whereas they were 0 to 4.0 microng/100 ml in hypopituitary
      patients. It is concluded that this simple method is useful for the routine assay
      of plasma 11-deoxycortisol as a parameter of the metyrapone tests.

PMID- 1024043
TI  - Tax free financing of a medical office building.

PMID- 1024044
TI  - The art of medicine.

PMID- 1024045
TI  - Arbitration: alternative to litigation.

PMID- 1024046
TI  - Accreditation and ambulatory care.

PMID- 1024047
TI  - Medical director: man of many facets.

PMID- 1024048
TI  - Is this the year for National Health Insurance?

PMID- 1024049
TI  - Five steps to expanding facilities.

PMID- 1024050
TI  - Automated patient billing: we did it our way.

PMID- 1024051
TI  - Collective bargaining.

PMID- 1024052
TI  - Medical audits: one group's practical approach.

PMID- 1024053
TI  - Foundations: the key to group growth.

PMID- 1024055
TI  - Spotlight on the staff. Food service.

PMID- 1024054
TI  - New use for the attitude survey.

PMID- 1024056
TI  - New responsibilities for nurses.

PMID- 1024057
TI  - Controlling theft: the hidden drain.

PMID- 1024058
TI  - Occurrence of uncommon Salmonella serotypes in human infections.

PMID- 1024059
TI  - Clinical and epidemiological studies on V. parahaemolyticus infection in Calcutta
      (1975).

PMID- 1024060
TI  - Ocular leprosy.

PMID- 1024061
TI  - Studies on human ascaris: purification of trypsin inhibitor.

PMID- 1024062
TI  - T-strain mycoplasma in human genital tract infections.

PMID- 1024063
TI  - Poisoning by ergoty bajra (pearl millet) in man.

PMID- 1024064
TI  - Diagnosis of recurrence of rheumatic fever in rheumatic heart disease--a re
      evaluation of Duckett Jones Criteria.

PMID- 1024065
TI  - Social class and psychiatric disturbance: a community study.

PMID- 1024066
TI  - Effects of polycationic amines and streptomycin on the structure of N
      ethylmaleimide treated rat liver ribosome.

PMID- 1024067
TI  - Is methemoglobin reduction test a true index of G-6-PD deficiency?

PMID- 1024068
TI  - A simple apparatus and technique for crossed antigen-antibody electrophoresis.

PMID- 1024069
TI  - Demonstration of immunological similarity between tumour antigen and tumour
      associated foetal antigen.

PMID- 1024070
TI  - Plaque formation of dengue viruses in Vero cell culture under
      carboxymethylcellulose overlay.

PMID- 1024071
TI  - Observation on second heterotypic dengue virus infection in mice.

PMID- 1024072
TI  - A study of chronic hepatitis in northern India.

PMID- 1024073
TI  - Serological evidence of arbovirus activity in birds and small mammals in Japanese
      encephalitis affected areas of Bankura district, West Bengal.

PMID- 1024074
TI  - Sero-epidemiological study of measles virus infection in and around Chandigarh.

PMID- 1024075
TI  - Edwardsiella tarda in a variety of human infections.

PMID- 1024076
TI  - Insecticide susceptibility studies in populations of Aedes aegypti from
      Maharashtra State, India.

PMID- 1024077
TI  - Humoral immune response during pregnancy.

PMID- 1024078
TI  - Adrenocortical function in breast cancer.

PMID- 1024079
TI  - Comparative study of fluorescent and Papanicolaou's techniques for detection of
      carcinoma of cervix uteri.

PMID- 1024080
TI  - Influence of high dose of estradiol on ICRC mouse bearing transplanted mammary
      tumours.

PMID- 1024081
TI  - Parathyroid preservation and transplantation.

PMID- 1024082
TI  - Epidermal prostaglandin and histamine in UV-induced erythema reaction.

PMID- 1024083
TI  - An endoscopic and gastric secretory study of non-ulcer dyspepsia.

PMID- 1024084
TI  - Cardiac action of Tribulus terrestris.

PMID- 1024085
TI  - Sensitivity of vibrio group of organisms to minocycline--a new tetracycline
      derivative.

PMID- 1024086
TI  - Acquisition of immunologic capacity by human newborns.

PMID- 1024087
TI  - Neonatal meningitis.

PMID- 1024088
TI  - Serum proteins with special reference to immunoglobulins in premature Indian
      neonates.

PMID- 1024089
TI  - Morbidity due to poliomyelitis in urban and rural area of Gujarat in pediatric
      population--a house to house survey.

PMID- 1024090
TI  - Socio-cultural factors affecting breast feeding and other infant feeding
      practices in an urban community.

PMID- 1024091
TI  - Triceps skin--fold thickness during infancy.

PMID- 1024092
TI  - Broncho pulmonary complications of measles: analysis of 100 cases.

PMID- 1024093
TI  - Malaria in Madras city.

PMID- 1024094
TI  - Pain abdomen-a clinical study.

PMID- 1024095
TI  - Myositis ossificans progressiva (a case report).

PMID- 1024096
TI  - Congenital methaemoglobinemia (report of a case).

PMID- 1024097
TI  - A "should" that has become an "is".

PMID- 1024098
TI  - Aims, organization, and initial studies of the Cross-National Project.
AB  - The US-UK Cross-National Project is conducting a series of trans-Atlanti
      comparisons of psychiatric practice and psychiatric disorders. The inital studies
      investigated the large US-UK cross-national differences reported in the public
      mental hospital statistics on adult admission rates of schizophrenia and the
      manic-depressive disorders. Three general strategies were adopted: (1) semi
      structured interviews with hospitalized patients aged 20-59 years; (2) rating of
      videotapes by samples of psychiatrists; and (3) systematic examination of case
      records. The results showed that routine hospital diagnoses were based on
      differing criteria in the two countries and it was this that accounted for the
      reported cross-national differences in admission rates. A method of making
      internationally reliable diagnoses was demonstrated.

PMID- 1024099
TI  - Assessment of the older psychiatric inpatient.
AB  - Instruments, whether used in psychometrics or in other fields, must have a
      practical application if they are to repay the care spent in their use and
      development. The Geriatric Mental State schedule was developed in response to the
      need to answer the question whether functional psychiatric disorders were being
      misdiagnosed as organic brain syndrome and, if so, to what extent this influenced
      treatment and outcome. In the hospitals studied it was found that American
      psychiatrists were more likely to diagnose organic brain syndrome than British
      psychiatrists. Although elderly patients with affective disorder were less likely
      to be given American patients was as good, if not better, than the outcome in the
      British patients.

PMID- 1024100
TI  - The geriatric mental status interview (GMS).
AB  - The Geriatric Mental Status interview (GMS) is a semi-structured interview
      technique for assessing psychopathology in elderly patients. It is administered
      by a trained interviewer in a session of less than one hour. Between 100 and 200
      question are asked and almost 500 items are rated. Twenty-one factor scores have
      been identified and the reliability of the ratings has been established. The
      interview is acceptable to the patient and is useful for making diagnostic
      distinctions and evaluation progress

PMID- 1024101
TI  - Reliability of psychiatric assessment in older patients.
AB  - A number of the causes of psychiatric diagnostic disagreement are discussed in
      this paper. The use of the Geriatric Mental Status interview to achieve
      diagnostic reliability is examined in three studies in which U.S.--U.K. Cross
      National Project psychiatrists rated and diagnosed thirty-two British and twenty
      one American patients. There were no systematic differences between U.S. and U.K.
      team members in their diagnoses; and agreement on six principal diagnostic
      categories was achieved in about three-quarters of the cases. The reliability fo
      the ratings of psychopathology that formed the basis for the diagnoses was
      satisfactory and is reported in detail.

PMID- 1024102
TI  - Distinctions between organic brain syndrome and functional psychiatric disorders:
      based on the geriatric mental state interview.
AB  - Discriminant function analysis was employed to study the ability of the Geriatric
      Mental Status interview to distinguish between patients diagnosed by the project
      as having an organic brain syndrome or a functional psychiatric disorder. In both
      New York and London, patients with organic brain syndrome scored significantly
      higher (p less than 0.05) than those with functional disorders on the factors of
      impaired memory, disorientation and incomprehensibility and significantly lower
      on the factors of depression and somatic concerns. Discriminant functions
      calculated from data on the New York and London patients separately significantly
      distinguished not only the patients on whom the functions were based but the
      patients in the other sample as well.

PMID- 1024103
TI  - The usefulness of a psychological test battery.
AB  - This paper discusses the usefulness of a battery of psychological tests
      administered to a group of psychiatric geriatric patients in New York and London,
      as an assessment of cognitive impairment. Two of the tests, the Paired Associate
      Learning Test, and the Digit Copying Test, were highly related to the diagnosis
      of organic brain syndrome or functional disorder made independently by a
      psychiatrist in a clinical interview. Prognostic predictions in disagreement
      cases were no better or no worse by psychiatric diagnosis than by psychological
      tests. Compared to a simple clinical test of disorientation derived from the
      psychiatric interview, psychological tests were more highly correlated to
      independent measures of patients' self-care capacity and duration of
      hospitalization, but equally related to psychiatric diagnosis. The verbal subtest
      proved to be the more useful of the psychological tests given. The logistics and
      difficulties of administering psychological tests to this specialized population
      are discussed, e.g. patients' physical limitations, communication problems; as
      well as efforts in this study to minimize these problems.

PMID- 1024104
TI  - The performance test of activities of daily living.
AB  - A structured-performance test requiring patients to demonstrate selected
      activities of daily living was designed to objectively measure the self-care
      capacity of geriatric psychiatric patients. The background, rational, usefulness,
      and specific administration and scoring procedures are presented. The test is
      simple to administer and promises to be a useful diagnostic and prognostic tool.

PMID- 1024105
TI  - A measure of the fulfillment of health needs.
AB  - Female patients, sixty-five of age and over, admitted to acute medical and
      psychiatric wards of a municipal hospital were observed directly and
      unobtrusively for a three hour time period every other day during the first two
      weeks of hospitalization. The behaviors of the patients and of those who
      interacted with them were recorded and later categorized according to fifteen
      activities defined as representing basic health needs. Behaviors were compared
      according to the outcome of hospitalization, discharge, transfer to another ward
      or institution, or death. Differences which distinguished patients who were
      discharged from those who died were found in the activities of movement,
      comunication, and learning. Behaviors observed at different points in time during
      hospitalization also were compared. This study is the first step in the
      development of an instrument to measure the perceived satisfaction of health
      needs of geriatric patients in institutions.

PMID- 1024106
TI  - Axial deviations of the knee with secondary arthrosis. Correction by high
      osteotomy of the tibia and fibula.
AB  - The authors describe a surgical technique for high tibio-fibular osteotomy used
      eighty seven times to correct varus or valgus deviations causing arthrosis of the
      knee. Osteotomy of the tibia is carried out above the tibial tuberosity. Fixation
      is by two nails with a compression device. This allows immediate movement of the
      knee, thereby preventing stiffness. After forty five days the osteotomy is
      usually consolidated. Of the complications, only the neuro-muscular type is of
      importance and the possible causes of this are discussed. The overall results are
      good and the technique described has proved to be effective in the treatment of
      mechanical arthrosis of the knee.

PMID- 1024107
TI  - Surgical treatment of poliomyelitic scoliosis.
AB  - Between 1968 and 1973 forty nine patients suffering from poliomyelitic scoliosis
      were treated surgically at the Rizzoli Institute. They were due to asymmetrical
      paralysis and contracture in the muscles of the trunk and limbs. Associated
      pathological conditions were found, such as pelvic obliquity, and vascular and
      trophic changes due to ganglionic lesions. The differing incidence and
      combination of these factors gave rise to various clinical types of spinal
      deformity. The average severity of curve was 39 degrees, the localisation was
      predominantly central, the average extent was ten vertebrae, and there was a
      marked predominance of right convexity (twenty nine out of thirty six). The rate
      of progression was maximum during puberty and almost negligible after bony
      maturity. It was greater in males and was unfavourably affected by the severity
      and asymmetrical distribution of the paralysis, by the early appearance of the
      disease, by high localisation of the deformity, and by the erect posture in
      patients who were ambulant. The most frequent visceral complications were in the
      respiratory system (ten patients with a deficit over 50%), followed by cardiac
      changes. Surgical treatment was adopted in patients with progressive curves over
      60 degrees, because of the inevitable deterioration in their general condition
      and the tendency of the deformity to become fixed. Pre-operative correction by
      Halo-traction results (52% correction) than Risser plasters (38%). Posterior
      arthrodesis by Harrington's method was carried out in all the more recent cases
      (forty four). Post-operative plaster was maintained for eight months and then
      replaced by an orthopaedic corset. At bony maturity there was an averaged
      improvement of 35% in the angle of curvature, and an average improvement of 6% in
      vital capacity. The best corrections were obtained in patients under fourteen
      (42%), in dorso-lumbar scoliosis (40%) and in patients with curves above 100
      degrees (38%). There was an average increase in height of 9.1 cms and a reduction
      in the gibbus of 3.4 cms. The complications included one traumatic pneumothorax,
      eight pseudarthroses, and breakage of the distraction rod in two cases resulting
      in complete relapse of the deformity. In six cases the upper hooks became loos
      and there were two cases of postoperative staphylococcal infection. In the
      distally sited curves our present policy is towards combining posterior
      arthrodesis with Dwyer's anterior interbody fusion.

PMID- 1024108
TI  - A new total knee prosthesis: the "total-condylar".
AB  - We have described the instrumentation and surgical technique of a new total knee
      prosthesis, the Total-Condylar, designed at the Hospital for Special Surgery (New
      York) and which we are the first to use in Italy. This prosthesis has evolved
      from the "sliding" prosthesis and seems to us to constitute a real step forward.
      The femoro-patellar compartment is completely substituted. The cruciate ligaments
      are removed, which markedly increases the possibility of correcting even severe
      deformities. The fixation of the tibial component is improved by the adoption of
      a short stem. The prosthesis has a certain intrinsic stability on weightbearing.
      The surgical technique is characterised by bone sections perpendicular to each
      other by the use of aligning instruments which simplify the operation. Our
      experience is just beginning (five cases) but our results so far are very
      encouraging and correspond to those reported in a very much larger series in the
      United States.

PMID- 1024109
TI  - Osteofibrous dysplasia of long bones a new clinical entity.
AB  - A new clinico-pathologic entity is described. It is defined as osteofibrous
      dysplasia of long bones, and is based on twenty two personal observations to
      which are added seventeen cases from the literature. This dysplasic congenital
      lesion is clearly differentiated from fibrous dysplasia by clinical, radiographic
      and histological characteristics and by its clinical course. These features may
      be summarised as follows: 1) Slight predominance of the male sex. 2) Very early
      age of onset either at birth or in the first years of life. 3) Site almost
      exclusively tibial, sometimes also in the fibula. Localisation predominantly in
      the middle third of the tibial diaphysis, but sometimes in the distal or proximal
      third. In the fibula, it is always at the distal third. 4) The lesion is painless
      and generally causes bony enlargement. There is often slight anterior bowling and
      more rarely, slight varus of valgus bowing. Pathological fracture may occur;
      rarely there is a pseudarthrosis. 5) The radiographic appearances are very
      characteristic, with enlargement of the bone, intracortical osteolytic lesions
      with thinning or disappearance of the external cortex, sclerotic reaction on the
      medullary aspect, and narrowing of the medullary canal. 6) The histological
      features are also typical, consisting of fibrous tissue enclosing bone trabeculae
      lined by osteoblasts and a "zonal" architectural pattern. 7) Sometimes the lesion
      tends to heal spontaneously in the very early years of life; in other cases it is
      moderatley progressive. It relapses frequently after curettage, but such
      recurrences are generally non-progressive. In some cases slight anterior bowing
      persists permanently. 8) Surgery should be restricted to patients over the age of
      five in whom the lesion is extensive, with imminent or actual pathological
      fracture, and to the rare cases of pseudarthrosis. The results are good even in
      cases of relapse or pseudarthrosis. The correction of residual bowing, if
      indicated, can safely be carried out with one or more osteotomies at the age of
      ten to twelve years.

PMID- 1024110
TI  - Gluteal fibrosis.
AB  - After reviewing the literature the authors discuss the aetiology and pathogenesis
      of gluteal fibrosis. We believe that the condition occurs more frequently than is
      thought. If this is borne in mind when dealing with children from four to six
      years old, presenting with abnormal gaits, an early diagnosis can be made. As
      regards treatment, we agree with those authors who maintain that if diagnosed
      early the lesion can be treated successfully by physiotherapy alone. In more
      advanced cases, Z lengthening of the tendon is indicated.

PMID- 1024111
TI  - Respiratory function in severe scoliosis before and after treatment (a review of
      76 cases).
AB  - The authors carried out a study of respiratory function in seventy six patients
      suffering from severe scoliosis of different types; forty five idiopathic,
      sixteen poliemyelitic, ten congenital, and five neurofibromatosic. The age
      incidence was from a minimum of eleven years to a maximum of thirty three, with
      the average around fifteen years. The site of the deformity was predominantly
      dorsal (fifty cases), though there were also lumbar and dorso-lumbar types. The
      average angle of curvature (Cobb) before treatment was 110 degrees. Arthrodesis
      by the Harrington technique was carried out on all patients after correction with
      a Risser-type plaster in sixty nine cases, and Halo-traction in seven cases. The
      post operative period in plaster was about eight months. Spirometric tests were
      carried out before treatment, after preoperative correction, and two to three
      years after operation, always with the chest out of plaster. The results of these
      tests are expressed as percentage reductions in the maximum ventilation compared
      with the average normal values in the tables reported by Baldwin et al. (1948).
      The values obtained before commencing treatment showed that lumbar scoliosis even
      if very severe, never leads to severe respiratory deficits. There is no linear
      relationship between the severity of the curve and the respiratory deficit,
      though there is a general connection between them. Tests of respiratory function
      were carried out after corrective treatment, both before and after operation and
      at a two year follow up. There was an overall average improvement of 10% in the
      respiratory deficit, with a maximum of about 20% in a group of twenty two
      patients with the most severe deficit before commencing treatment. Follow-up
      three years after operation showed the improvement in respiratory fimction had
      been maintained. The authors conclude that arthrodesis by the Harrington
      technique does not diminish the respiratory gain achieved by pre-operative
      correction. On the contrary, it stabilises it and maintains it over the three
      year follow-up period of the present survey.

PMID- 1024112
TI  - Reappraisal of the treatment of fractures of the calcaneus involving the subtalar
      joint.
AB  - From our findings it appears that no one method of treatment is infallible and
      that functional and anatomical restitutio ad integrum of the fractured heel
      cannot be obtained. Each method has its advantages and disadvantages and these
      are not only inherent in the method itself, but also depend on how it is applied.
      The treatment must be chosen according to the lesion and cannot be standardised
      because of the variable and complex nature of these fractures. Other factors to
      be considered are whether it is bilateral, whether there are multiple injuries,
      and the general condition of the patient etc. In fractures with depressions of
      the mixed horizontal type the Stulz method of treatment seems to be the best.

PMID- 1024113
TI  - Classification and treatment of intercondyloid fractures of the humerus.
AB  - The authors describe the satisfactory results obtained in sixteen intercondyloid
      fractures of the humerus, thirteen of which were treated surgically. The
      preference for surgical treatment in such fractures is based in the assumption
      that, as in all articular fractures, a good functional result can only be
      achieved if there is the most perfect possible reconstruction of the fragments
      and the joint surface. A classification is therefore suggested which is based not
      purely on anatomical criteria, but is also related to treatment and prognosis.
      The slendor nature of the distal end of the humerus and the danger of metal
      reaction call for the use of fixation devices that are efficient but slender,
      such as fine screws and crossed wires. The precise method of fixation is
      conditioned above all by the direction of the fracture lines. More solid fixation
      with early mobilisation can be achieved by compression screws, and less solid
      fixation with longer immobilisation is achieved by fixation with crossed
      Kirschner wires. Consequently, the more oblique types of fracture with fragments
      with long beaks that allow more stable fixation with compression screws have the
      more favourable prognosis. In the evaluation of results, the authors emphasize
      the importance of using parameters which take into account the functionally
      useful range of joint movement.

PMID- 1024114
TI  - Intraosseus lipoma.
AB  - The authors present a case of intraosseus lipoma seen at the Orthopaedic Clinic
      of the University of Bari, bringing the total in the world literature to thirty
      cases. The tumour is a benign primary neoplasm of bone, made up of mature adipose
      tissue containing atrophic bone trabeculae. This affection is a definite entity
      quite distinct from parosteal lipomas arising in periosteum, fasciae and muscles
      which only affect the bone secondarily by compression or direct invasion.
      Emphasizing the extreme rarity of the tumour, the authors discuss its clinical,
      radiological, anatomical and pathological features. The differential diagnosis is
      with certain dysplasic and neoplastic lesions of bone such as: bone cyst, non
      ossifying fibroma, aneurismal cyst, monostotic fibrous dysplasia, and solitary
      myeloma. Complete removal is followed by cure.

PMID- 1024115
TI  - The dual role of the health organization physician.

PMID- 1024116
TI  - The case for hospital-based epidemiology departments.

PMID- 1024117
TI  - Who is running the show.

PMID- 1024118
TI  - Why continuing medical education?

PMID- 1024119
TI  - Use of an ultrasonic blood flow monitor for determining fetal viability in the
      rhesus monkey (Macaca mulatta). A preliminary study.
AB  - Ultrasonic stethoscopy proved to be a reliable and convenient technique for
      determing fetal viability in Macaca mulatta. Examinations, begun at day 150 of
      gestation in 33 monkeys and between days 32 and 58 in four other animals, were
      repeated at intervals of one to seven days. The earliest time of detecting blood
      flow in the fetal placenta was 42 days of gestation, fetal heart sounds geing
      discerned later. Three types of fetal cardiac rhythms were recognized: (1) a
      constant rate during most of pregnancy, (2) fluctuations associated with uterine
      contractions during labor, and (3) sudden transient bradycardia during violent
      rotations of the cephalically presented fetus.

PMID- 1024120
TI  - Antenal sex determination using amniotic fluid of the baboon (Papio sp.).
AB  - Antenatal determination of sex in the baboon was performed by evaluating the
      percentage of sex chromatin bodies present in the epithelial cells of amniotic
      fluid obtained during or immediately following cesarean section. Female sex
      chromatin patterns revealed a mean of 39.2% positive sex chromatin; the mean in
      males was less than 5%. This procedure is accurate and simple to perform.

PMID- 1024121
TI  - Surface architecture of the plant cell: biogenesis of the cell wall, with special
      emphasis on the role of the plasma membrane in cellulose biosynthesis.
AB  - Cell wall structure and biogenesis in the unicellular green alga, Oocystis
      apiculata, is described. The wall consists of an outer amorphous primary layer
      and an inner secondary layer of highly organized cellulosic microfibrils. The
      primary wall is deposited immediately after cytokinesis. Golgi-derived products
      contribute to this layer. Cortical microtubules underlie the plasma membrane
      immediately before and during primary wall formation. They function in
      maintaining the elliptical cell shape. Following primary wall synthesis, Golgi
      derived materials accumulate on the cell surface to form the periplasmic layer.
      This layer functions in the deposition of coating and cross-linking substances
      which associate with cellulosic microfibrils of the incipient secondary wall.
      Secondary wall microfibrils are assembled in association with the plasma
      membrane. Freeze-etch preparations of untreated, living cells reveal linear
      terminal complexes in association with growing cellulosic microfibrils. These
      complexes are embedded in the EF fracture face of the plasma membrane. The newly
      synthesized microfibril lies in a groove of the outer leaflet of the plasma
      membrane. The groove is decorated on the EF fracture face by perpendicular
      structures termed "ridges". The ridges interlink with definitive rows of
      particles associated withe PF fracture face of the innter leaflet of the plasma
      membrane. These particles are termed "granule bands", and they function in the
      orientation of the newly synthesized microfibrils. Microfibril development in
      relation to a coordinated multienzyme complex is discussed. The process of cell
      wall biogenesis in Oocystis is compared to that in higher plants.

PMID- 1024122
TI  - Nature and origin of patterns of changes in cell shape in embryos.
AB  - Spatial patterns of the future elongation of cells exist in the early embryo. In
      the newt, such a pattern of changes of cell shape contributes to the formation of
      the neural plate. Regardless of where neural plate cells are transplanted, they
      change shape as prescribed by the pattern. Embryonic induction has a role in
      establishing this pattern.

PMID- 1024123
TI  - Interactions of neurotoxins with the action potential NA + ionophore.
AB  - Four neurotoxins that activate the action potential Na+ionophore of electrically
      excitable neuroblastoma cells interact with two distinct classes of sites, one
      specific for the alkaloids veratridine, batrachotoxin, and aconitine, and the
      second specific for scorpion toxin. Positive heterotropic cooperativity is
      observed between toxins bound at these two classes of sites. Tetrodotoxin, a
      specific inhibitor of the action potential Na+ current, inhibits activation by
      each of these toxins in a noncompetitive manner (KI=4-8 nM). These results
      suggest the existence of three functionally separable components of the action
      potential Na+ionophore: two regulatory components which bind activating
      neurotoxins and interact allosterically in controlling the activity of a third
      ion-transport component, which binds tetrodotoxin. The dissociation constant for
      scorpion toxin binding is increased 10-fold by depolarization of the cells with
      K+, suggesting that the scorpion toxin binding site is located on a voltage
      sensitive regulatory component of the ionophore.

PMID- 1024124
TI  - Interaction of charged lipid vesicles with planar bilayer lipid membranes:
      detection by antibiotic membrane probes.
AB  - A technique has been developed for monitoring the interaction of charged
      phospholipid vesicles with planar bilayer lipid membranes (BLM) by use of the
      antibiotics Valinomycin, Nonactin, and Monazomycin as surface-charge probes.
      Anionic phosphatidylserine vesicles, when added to one aqueous compartment of a
      BLM, are shown to impart negative surface charge to zwitterionic
      phosphatidylcholine and phosphatidylethanolamine bilayers. The surface charge is
      distributed asymmetrically, mainly on the vesicular side of the BLM, and is not
      removed by exchange of the vesicular aqueous solution. Possible mechanisms for
      the vesicle-BLM interactions are  discussed.

PMID- 1024125
TI  - [Perception and adaptation in ethology].

PMID- 1024126
TI  - [Perception and adaptation in psychoanalysis: from the sign of reality to the
      autonomic apparatus of ego].

PMID- 1024127
TI  - [Hypothesis and observation in clinical reasoning. Demystification of various
      traditional ideas on the methodology of medical clinic].

PMID- 1024128
TI  - [Problem of diphyllobothriasis and the scientific and practical tasks in its
      control].

PMID- 1024129
TI  - [Study of reagin-like antibodies and or their role in the mechanisms of immunity
      in larval ascaridiasis].

PMID- 1024130
TI  - [Reaction of albino rats to echinococcal antigen].

PMID- 1024131
TI  - [Pathomorphology of human hepatic echinococcosis and alveococcosis].

PMID- 1024132
TI  - [Evaluation of the effectiveness of the indirect hemagglutination test with
      Ascaris and Toxocara antigens in diagnosis of larva migrans symptom complex in
      man].

PMID- 1024133
TI  - [Experimental therapy of alveococcosis. 3. Effect of thiabendazole, sarcoylsin
      acridine, levamisole and mebendazole on the development of larval cysts in albino
      mice].

PMID- 1024134
TI  - [Study of the effect of phenasal on different segments of cestode strobila].

PMID- 1024135
TI  - [Albino mice, infected with Nippostrongylus braziliensis (migratory stage) as a
      model for experimental therapy of larval nematode infections].

PMID- 1024136
TI  - [Effect of fractional doses of phenasal, trichlorophene, dichlosal, and
      trichlosal on the cysticercoids and young forms of Hymenolepis in albino mice].

PMID- 1024137
TI  - [Phospholipid membranes as a model for the study of fasciolocide and toxic effect
      of chemotherapeutic preparations].

PMID- 1024138
TI  - [Specificity of proteolytic enzymes of Ascaris suum and Ascaridia galli].

PMID- 1024139
TI  - [Composition of volatile fatty acids of Ascaridia galli (Schrank 1788) and their
      effect on Eimeria tenella Railliet et Lucet 1891].

PMID- 1024140
TI  - [Cytoecological study of natural populations of malaria mosquitoes on the USSR
      territory. 1. Isolation of a new species of Anopheles in Maculipennis complex by
      the cytodiagnostic method].

PMID- 1024141
TI  - [Effect of the streptothricin group on bloodsucking mosquitoes. 3. Residual
      effect of aqueous solutions of phytobacteriomycin on the larva of Culex pipiens
      L].

PMID- 1024142
TI  - [Study of Coelomomyces milkoi Dudka et Koval, pathogenic for the horsefly
      larvae].

PMID- 1024143
TI  - [Dzungar hamsters- an experimental model for alveococcosis and echinococcosis].

PMID- 1024144
TI  - [Antihelmintic activity of polymorphic modifications of phenasal].

PMID- 1024145
TI  - [Achievements in the helminthiasis control in the Dnepropetrovsk district].

PMID- 1024146
TI  - [Comparative evaluation of the effectiveness of 2 methods of examination of
      everyday-use utensils for contamination with helminths' eggs].

PMID- 1024147
TI  - [Main results of research in medical parasitology in USSR in 1971-1975].

PMID- 1024148
TI  - [Study of trophozoites of Lamblia intestinalis from culture by scanning electron
      microscopy].

PMID- 1024149
TI  - [Study of growth of Lamblia intestinalis in culture for the purpose ofimprovement
      of cultivation method].

PMID- 1024150
TI  - [Persistence of Toxoplasma gondii in the stomach wall and intestinal wall of
      albino mice and guinea pigs in experimental toxoplasmosis].

PMID- 1024151
TI  - [Structure of local incidence of quartan malaria in USSR (1958-1975)].

PMID- 1024152
TI  - [Assessment of RSFSR regions by the degree of hazard of recurrence of malaria
      transmission and preventive measures].

PMID- 1024153
TI  - [Duration of quartan malaria].

PMID- 1024154
TI  - [Fauna and biology of bloodsucking Diptera (flies) in the Zeya region of the Amur
      district including a part of the Baikal-Amur Railway (BAR). 2. Midges
      (Ceratopogonidae), black flies (Simuliidae), horseflies (Tabanidae)].

PMID- 1024155
TI  - [Evaluation of the role of day length and temperature in reactivation of the ova
      of monocyclic mosquito species of the genus Aedes in the Moscow district].

PMID- 1024156
TI  - [Results of the epidemiological survey for tick-borne encephalitis in the part of
      the Baikal-Amur railroad (BAR) within the Irkutsk district in the early period of
      tis construction].

PMID- 1024157
TI  - [Certain data on the acaricidal properties of dilor].

PMID- 1024158
TI  - [Remote effects of the use of repellents. 2. Certain problems of regulations
      concerning the use of diethyltoluamide (DETA)].

PMID- 1024159
TI  - [Tetramisole and levamisole in the treatment of ascariasis].

PMID- 1024160
TI  - [Effectiveness of various antinematodal agents in larval ascariasis of albino
      mice].

PMID- 1024161
TI  - [Duration of follow-up of patients with hymenolepiasis after treatment].

PMID- 1024162
TI  - [Elaboration of the method of feeding of Culex pepiens molestus Forsk larvae for
      preparation of standard experimental material].

PMID- 1024163
TI  - [Origin of the precursors of urinary ammonia in normal humans and patients with
      chronic metabolic acidosis].

PMID- 1024164
TI  - [Familial renal glycosuria. Presence of alpha and beta particles of glycogen in
      the epithelial cells of the proximal half of the proximal tubule].

PMID- 1024165
TI  - [Glomerular diseases with prevalent IgA mesangial deposits. Clinical,
      histopathological and immunochemical comparative study].

PMID- 1024166
TI  - [Prognostic significance of some clinical and histological parameters in
      membranoproliferative glomerulonephritis (GNMP). Study of 112 cases].

PMID- 1024167
TI  - [Results of anticoagulant and dialytic therapy in the hemolytic-uremic syndrome
      in childhood].

PMID- 1024168
TI  - [Multicompartmental analysis of the phosphate pool in dialyzed uremic patients].

PMID- 1024169
TI  - [Na concentration in the dialysis fluid in hemodialytic treatment. Theoretical
      considerations and short-term clinical results].

PMID- 1024170
TI  - [The long-term use of a dialysate with high sodium content in short-term
      hemodialysis].

PMID- 1024171
TI  - [Osseous densitometry with I-125. Semiological value of long-term studies in
      uremic patients].

PMID- 1024172
TI  - Present role of teaching hospital in community health care.

PMID- 1024173
TI  - Needed changes in medical education.

PMID- 1024174
TI  - A review of the District Health Administration Research Project.

PMID- 1024175
TI  - Project Poshak--an integrated health and nutrition large-scale study for rural
      preschool children. Central India.

PMID- 1024176
TI  - Influence of private practice on integration of health services.

PMID- 1024177
TI  - Internship programme in medical education--an overview.

PMID- 1024178
TI  - The health centre in Japan--past, present and future.

PMID- 1024179
TI  - [Nonspecific lymphadenitis colli in children].

PMID- 1024180
TI  - [Treatment of mycoses in children with 5-fluorocytosine].

PMID- 1024181
TI  - [Dysplasia of the retroperitoneal lymphatic system with skin manifestations. Case
      report and lymphographic findings].

PMID- 1024182
TI  - [Surgical aspects of the problem of child abuse with special reference to
      injuries of the internal organs].

PMID- 1024183
TI  - [Diagnosis and differential diagnosis of primary erythrocytosis].

PMID- 1024184
TI  - [Effect of adrenaline on the coronary vessels, oxygen consumption and myocardial
      contractility in catecholamine-induced myocardial injury].

PMID- 1024185
TI  - [Effect of electric countershock on the indicators of excitability of the left
      ventricle].

PMID- 1024186
TI  - [Effect of beta-adrenergic block on the indicators of systemic hemodynamics and
      metabolism in the early post-resuscitation period].

PMID- 1024187
TI  - [Molecular-genetic nature of neoplastic transformation].

PMID- 1024188
TI  - [Effect of extracardiac inflammatory processes on the position of the electrical
      axis of the heart under experimental conditions].

PMID- 1024189
TI  - [Electrophysiological characteristics and energy provision of the brain function
      in traumatic shock].

PMID- 1024190
TI  - [Erythropoiesis inhibitor under conditions of experimental post-transfusion
      polycythemia in rats].

PMID- 1024191
TI  - [Anticholinesterase effect of diptheria toxin].

PMID- 1024192
TI  - [Quantitative immunoelectrophoretic analysis of blood serum proteins in burned
      rats].

PMID- 1024193
TI  - [Effect of leukocytic pyrogen on the leukopoiesis in intact rats].

PMID- 1024194
TI  - [Effect of drug treatment on the activity of enzymes, and the lipid and
      phospholipid spectra in acute experimental pancreatitis].

PMID- 1024195
TI  - [Method of reproduction of experimental chronic pneumonia].

PMID- 1024196
TI  - [Method of recording of contractions of the isolated smooth-muscle organs and
      tissues].

PMID- 1024197
TI  - [Homologous blood syndrome (the clinical and morphological manifestations and the
      methods of preventing it)].

PMID- 1024198
TI  - [Functional state of the erythrocyte membranes in acute renal insufficiency].

PMID- 1024199
TI  - [Correlation between the number of monocytes and granulocytes in the peripheral
      blood in lung cancer patients].

PMID- 1024200
TI  - [Effect of the storage temperature of preserved blood on the 2,3- and ATP content
      in erythrocytes].

PMID- 1024201
TI  - [Characteristics of transfusion therapy in massive hemorrhages in obstetrical
      practice].

PMID- 1024202
TI  - [Components of the fibrinolytic system of cadaveric blood in certain types of
      death].

PMID- 1024203
TI  - [Blood and lymph coagulation in heterotransfusional shock in dogs].

PMID- 1024204
TI  - [Study of the possibility of using cellulose phosphate borate for blood
      stabilization].

PMID- 1024205
TI  - [Massive cytopheresis in blood donors].

PMID- 1024206
TI  - [Donors for direct blood transfusion].

PMID- 1024207
TI  - [Obtaining active plasminogen from the blood plasma of those who have died
      suddenly].

PMID- 1024208
TI  - [Experience with the use of polyethylene oxide-400 (PEO-400) in the low
      temperature freezing of postmortem bone marrow cells].

PMID- 1024209
TI  - [Effectiveness of blood transfusions equivalent to the surgical blood loss].

PMID- 1024210
TI  - [Use of monolayer cultures of the bone marrow for the study of pathogenesis and
      determination of prognosis of the disease in patients with lymphogranulomatosis].

PMID- 1024211
TI  - [Study of the chromosomal complexes in patients with leukocytosis and leukopenia
      of obscure etiology].

PMID- 1024212
TI  - [Characteristics of synthesis of DNA and intracellular proteins in the bone
      marrow leukocytes in agranulocytosis].

PMID- 1024213
TI  - [Regulation of the hematopoietic stem cells].

PMID- 1024214
TI  - [Dynamics of formation of the fibroblast-like cells in the monolayer culture of
      cadaveric (postmortem) bone marrow].

PMID- 1024215
TI  - [Mitotic activity of the bone marrow cells in healthy men].

PMID- 1024216
TI  - [Clinical importance of the method of absolute magakaryocyte count in the
      trephine for the evaluation of the state of hematopoiesis in oncological
      patients].

PMID- 1024218
TI  - Corporate social responsibility in the insurance industry.

PMID- 1024217
TI  - Significance of left anterior hemiblock--the Great West Life experience.

PMID- 1024219
TI  - Coronary disease prevention.

PMID- 1024220
TI  - Medicine and the law--current perspectives.

PMID- 1024221
TI  - Health care in Canada.

PMID- 1024222
TI  - The medicine man.

PMID- 1024223
TI  - Murmurs and mortality.

PMID- 1024224
TI  - Clinical uses of frozen-thawed erythrocytes in pediatrics.
AB  - Frozen red cells have a definite place in the mangement of a transfusion service
      even if one does not include its originally intended use -- inventory control.
      Undoubtedly, the benefits achieved from frozen red cells can be accomplished in
      less expensive ways. However the growth in transsplantion and intensive
      chemotherapy with its concommiatant uses of granulocyte and platelet support
      predict a greater upsurge in the use of frozen red cells in the very near future.

PMID- 1024225
TI  - [Atrial electrostimulation in investigation of angina pectoris].

PMID- 1024226
TI  - [The morphological substrate and diagnosis of some ictero-hydropigenous syndromes
      connected with various hepatopathies of subacute development].

PMID- 1024227
TI  - [Bacteriological study of acute bacterial bronchopneumopathies. I].

PMID- 1024228
TI  - [The minor post-streptococcal syndrome].

PMID- 1024229
TI  - Observations on morphology and significance of electrocardiographic waves of
      atrial fibrillation.

PMID- 1024230
TI  - [Benign duodenal tumors].

PMID- 1024231
TI  - [Injuries of the spleen].

PMID- 1024232
TI  - [Transaminases in localized traumatic meningo-cerebral dilaceration].

PMID- 1024233
TI  - [2 decades of experience of testing the sensitivity of bacteria to antibiotics].

PMID- 1024234
TI  - [Current epidemiological characteristics of typhoid fever in Rumania].

PMID- 1024235
TI  - [Various factors conditioning the substress phenomenon in automated work].

PMID- 1024236
TI  - [Colorimetric determination of acrolein in industrial air and residual waters].

PMID- 1024237
TI  - [Oxygen consumption and histopathological changes in rat bronchopulmonary tissue
      under the action of hemp and flax dust extracts].

PMID- 1024238
TI  - [The particle size of dexamethasone incorporated in ointments and its relation to
      the penetration of emulsion ointments into the horny layer of the skin in vivo].

PMID- 1024239
TI  - [Psuedocholinesterase changes after pancuronium administration].

PMID- 1024240
TI  - [Studies of the rectal resorption of strychnine sulfate from suppositories
      prepared with indigenous excipients].

PMID- 1024241
TI  - [Data on the stability of vitamin A in some ointments and ophthalmic solutions].

PMID- 1024242
TI  - [The glucose tolerance test (GTT) in aged subjects in ambulatory treatment and in
      old age homes in Jassy].

PMID- 1024243
TI  - [Sphenopalatine ganglion syndrome of dental origin].

PMID- 1024244
TI  - [Heat treatment of methyl polymethacrylate].

PMID- 1024245
TI  - [Proposals for the standardization of the serodiagnosis of syphilis (SDS). I].

PMID- 1024246
TI  - [Hypersecreting parathyroid carcinoma. Considerations on a case].

PMID- 1024247
TI  - [Case for diagnosis: subacute sclerosing panencephalitis].

PMID- 1024248
TI  - [Possible significance of human patients with "swine" influenza virus in January
      February,1976 at Fort Dix, New Jersey, USA, and theories concerning the cause of
      deaths in the influenza pandemic of 1918-1919].

PMID- 1024249
TI  - [Morpho-lymphographic comparison between inflammatory and dystrophic changes in
      lymph nodes].

PMID- 1024250
TI  - Comparative cytogenetic and cytologic study in malignant lymphomas.
AB  - The possibility of a cytogenetic-cytologic correlation with implications in the
      diagnosis, evolutivity and prognosis of malignant lymphomas was studied.
      Cytogenetic investigations were carried out comparatively in the lymph node and
      spleen lymphoid cells from 25 patients with malignant lymphomas and in normal
      subjects or patients with malignant tumors. The dominant malignant cellular type
      was found to correspond genotypically to the abnormal clone. In lymphomas with
      more differentiated cells the chormosomal abnormalities were limited to a single
      chromosomal group, while in those with less differentiated cells there were many
      clonal chromozomal abnormalities. The pathogenic significance of an extra
      chromosome in the C-group (observed in most of the cases) is discussed.

PMID- 1024251
TI  - Transfer factor for the lung, airway obstruction and hyperinflation in chronic
      bronchitis and emphysema.
AB  - The interrelationships of breath holding lung transfer factor (TCO) and transfer
      coefficient (KCO) with ventilatory obstruction (FEV1.0) and FEV1.0/VC) and
      hyperinflation (RV and RV/TLC) were studied in 37 patients with chronic
      nonspecific lung disease with a FEV1.0 of 1.5 litre or less classified as
      "bronchitic", "emphysematous" or "intermediate" according to Nash, Briscoe and
      Cournand (1965). No relationships could be found between TCO and airway
      obstruction or hyperinflation. KCO tended to decrease as RV increased (r=-0.26)
      and was weakly related to the FEV1.0/VC ratio in "intermediate" (r=0.34) and
      "emphysema" (r=0.29) patients but these relationships were nonsignificant.

PMID- 1024252
TI  - Results obtained with the weight reducing regimens by varying the dietary caloric
      values.
AB  - Eleven grossely obese females were placed successively on a 4 day total fasting
      diet, a 4-5 day hypocaloric diet of 220 calories consisting exclusively of
      proteins and finally a 450 mixed calorie diet consisting of 15 g carbohydrates,
      30 g proteins and 30 g lipids. At the beginning of the study and at the end of
      every dietary period, the weight free fatty acids, plasma glycerol, insulinemia,
      and growth hormone were measured and estimated. The nonsignificant changes of the
      biologic parameters investigated have led the authors to the conclusion that the
      450 mixed calorie diet suggested by them is more favourable being better accepted
      by the patients and therefore more easy to maintain for a longer period of time
      even by out patients.

PMID- 1024253
TI  - The monophasic action potentials of the intact canine heart.
AB  - Monophasic action potentials were recorded in 7 mongrel dogs, endocavitarily,
      from heart in situ and from the epicardial surface with open chest thus revealing
      the characteristic configuration of the different chambers. The duration of the
      monophasic action potential showed a good correlation with the cycle length,
      demonstrated during endocavitary electrostimulation.

PMID- 1024254
TI  - Angiotensin II. Vascular reactivity and humoral effects.
AB  - The vasopressor response to angiotensin II was found useful in the differential
      diagnosis of arterial hypertension and for a better understanding of its
      pathogenesis. Sodium supply was proved to influence significantly the pressor
      response to angiotensin II and not that to noradrenaline thus implying the
      presence of arterial receptors which bind angiotensin specifically. Angiotensin
      caused an increase of the urinary excretion of electrolytes in hypertensive
      patients and a decreased electrolyte excretion in normotensives. In most
      hypertensive patients angiotensin was found to decrease the plasma
      angiotensinogen and to activate the bradykinin-bradykininogen and fibrinolytic
      systems. In the presence of urinary infection angiotensin increased the platelet
      adhesiveness and the thrombelastographic changes proved that in this condition
      angiotensin increases the tendency to thrombosis.

PMID- 1024256
TI  - Is rehabilitation of patients with chronic bronchial asthma possible.
AB  - Based on his own experience and on the data in the literature the author
      considers that rehabilitation of adults with chronic bronchial asthma is possible
      at any stage of disease if there are no complications or morbid associations to
      prevent it. Rehabilitation of chronic asthmatic patients requires the close
      collaboration of several specialists such as allergologists, chest physicians,
      psychologists, physical therapists, balneologists, etc. Rehabilitation in
      asthmatic patients may only be considered successful if they resume full-time
      work (in case they had been in receipt of compensation), if the medical leaves
      are fewer and shorter and if the drug therapy is reduced or null. The author
      considers that since bronchial asthma in the whole population of Romania has an
      incidence of 2.3-2.9% rehabilitation, though costly and sometimes "desperate", is
      still worth while trying for its medical, economical and psychological
      implications.

PMID- 1024258
TI  - Breathlessness and blood oxygen tension in patients with chronic bronchitis and
      emphysema.
AB  - The dyspnea grade (MRC scale) was confronted with the arterial oxygen tension
      (PaO2) measured at rest in a group of 51 patients with chronic obstructive lung
      disease with moderate or severe impairment of ventilatory function (FEV 1.0 less
      than 1.5 1). For the group as a whole no correlation was found, but in the
      "bronchitic" subgroup (clinical-roentgenologic and biologic criteria) a tendency
      of PaO2 to decrease with the increase in dyspnea severity was apparent. The
      linear correlation coefficient did not attain the significance threshold owing to
      the limited number of observations (r = 0.46; p greater than 0.05).

PMID- 1024259
TI  - Spontaneous aorta and coronary lesions in mountain mammals. I. The Carpathian
      deer (Cervus elaphus).
AB  - Arterial lesions were investigated in 48 adult wild Carpathian deers (Cervus
      elaphus). Aortas from 36 animals and fragments from the main coronary trunks of
      all the animals were studied histologically and histochemically. In 44.4% of the
      animals the specimens studied presented gross intimal lesions in the aorta
      consisting histologically of fibrous plaques (especially situated in the thoracic
      segment) and/or intimal musculo-elastic thickenings with lipid deposits or fatty
      streaks (especially in the abdominal segments). In only 5 of the 48 animals the
      coronary arteries presented slight intimal thickenings, free of lipids. The
      results obtained are discussed in relation with the possible effect of natural
      nutrition.

PMID- 1024260
TI  - Disturbances of cellular immunity in rheumatic fever.
AB  - The alteration of cellular reactivity was investigated in 20 patients with
      rheumatic fever at the first rheumatic attack or in relapse with confirmed heart
      damage. The results obtained by studying in parallel ESR, the ASLO titer, IDR to
      streptococci and the degree of leukocyte migration inhibition proved that the
      onset of rheumatic attack was preceded by a deep disturbance of the cellular
      immunity. The migration inhibition values were between 50 and 60% (as compared
      with 10% in the normal controls) in over 85% of the patients investigated. It is
      emphasized that the selection of cases of streptococcal angina should be made
      very carefully and that sometimes it is necessary to use a more specific method
      for the detection of rheumatic fever in its preclinical stage.

PMID- 1024261
TI  - Electrocardiographic diagnosis of experimentally-induced myocardial infarction
      during cardiac electrostimulation.
AB  - The sequential ECG changes were studied by the Sodi-Pallares' method in 10 dogs
      before and after experimentally induced myocardial infarction of the left
      ventricle during right and left artificial stimulation. Right ventricular
      endocardial stimulation produced patterns of left bundle branch block in 9 dogs
      and of right bundle branch block in one, while left ventricular stimulation
      caused right bundle branche block patterns in 9 animals. Records during right
      ventricular stimulation after myocardial infarction showed in the peripheral
      leads myocardial necrosis only in two animals, while in the epicardial leads
      necrosis was certain in 2 animals (Q wave) probable in 6 (S-T segment elevation)
      and suggestive in 2 (T wave negativity). Myocardial necrosis during left
      ventricular stimulation was evident in the peripheral leads in 2 animals,
      probable in 6 and suggestive in one. The experimental data suggest that
      myocardial necrosis can be diagnosed in some cases during right and left
      ventricular artificial stimulation.

PMID- 1024262
TI  - Observations on neurasthenia and neurasthenia-like syndromes in a group of women
      working in textile industry.

PMID- 1024263
TI  - The mobility of the thinking process in aphasics.

PMID- 1024264
TI  - A study of aminoacidemia and aminoaciduria in epileptic children.

PMID- 1024265
TI  - [Analysis of various clinico-laboratory indicators of hepatic coma in chronic
      liver diseases].

PMID- 1024266
TI  - [Endoscopic diagnosis of diseases of the upper portion of the digestive tract
      under polyclinical conditions].

PMID- 1024267
TI  - [Certain humoral and cellular immunological indicators in different forms of
      pancreatitis].

PMID- 1024268
TI  - [Changes in the gastric mucosa in acute poisoning with corrosive substances
      (according to the data of gastrofibroscopy and aimed gastrobiopsy)].

PMID- 1024269
TI  - [Use of osmotic diuresis in clinical toxicology].

PMID- 1024270
TI  - [Replacement therapy in acute nomimmune thrombocytopenia].

PMID- 1024271
TI  - [Treatment of mushroom, Amanita phalloides, poisoning].

PMID- 1024272
TI  - [Werner-Morrison syndrome or "pancreatic cholera"].

PMID- 1024273
TI  - [Current possibilities of a therapeutic clinic in certain emergency cardiological
      condtions].

PMID- 1024274
TI  - [Means of therapeutic correction of disorders of central and regional
      hemodynamics in acute circulatory insufficiency caused by ischemic heart
      disease].

PMID- 1024275
TI  - [Organization of medical service to patients with acute coronary insufficiency as
      means of the control of pre-hospital lethality].

PMID- 1024276
TI  - [New approach to therapy of various paroxysmal disorders of cardiac rhythm].

PMID- 1024277
TI  - [Organization od express-diagnosis and treatment of acute respiratory
      insufficiency in the cardiological intensive therapy unit].

PMID- 1024278
TI  - [New therapeutic possibilities of current bronchoscopy in acute respiratory
      insufficiency].

PMID- 1024279
TI  - [Certain clinico-biochemical prerequisites for emergency therapy in chronic
      respiratory insufficiency].

PMID- 1024280
TI  - [Emergency treatment of bronchial asthma].

PMID- 1024281
TI  - [Certain immune and hormonal shifts in infectious-allergic bronchial asthma in
      the exacerbation phase].

PMID- 1024282
TI  - [Hypertensive crisis (problems of classification and emergency aid)].

PMID- 1024283
TI  - [Use of a modified method of electromyography of the respiratory muscles for
      early and differential diagnosis of acute respiratory insufficiency].

PMID- 1024284
TI  - [Recurrent pulmonary thromboembolism].

PMID- 1024285
TI  - [Emergency treatment of comatose states in diabetes mellitus].

PMID- 1024286
TI  - [Blood 17-hydroxycorticosteroids and their elimination during hemodialysis in
      acute and chronic renal insufficiency].

PMID- 1024287
TI  - [Diagnostic and therapeutic role of splenectomy in Hodgkin's disease].

PMID- 1024288
TI  - [Prevalence in USSR, clinical aspects, treatment and prevention of hemolytic
      anemia caused by hereditary glucosephosphate dehydrogenase deficiency].

PMID- 1024289
TI  - [Certain problems of pathogenesis of nephrogenic anemia. Proliferative capacity
      of erythroid cells of the bone marrow of patients with chronic diffuse
      glomerulonephritis].

PMID- 1024290
TI  - [Clinical aspects, diagnosis and treatment of hereditary hemolytic anemia caused
      by carrier state of unstable hemoglobin].

PMID- 1024291
TI  - [Certain characteristics of erythropoiesis in rheumatoid polyarthritis].

PMID- 1024292
TI  - [Examination of blood according to Bolen's method in ambulatory practice].

PMID- 1024293
TI  - [Acute renal insufficiency of toxic etiology].

PMID- 1024294
TI  - [Various "masks" caused by metastases of tumors into the heart].

PMID- 1024295
TI  - [Effective assimilation of iron from marmalade enriched with iron sulfate].

PMID- 1024296
TI  - [Lofgren's syndrome].

PMID- 1024297
TI  - [Study of delayed hypersensitivity with the aid of intradermal test with
      phytohemagglutinin in lymphocytic leukemia].

PMID- 1024298
TI  - [Spontaneous remission in lymphocytic leukemia].

PMID- 1024299
TI  - [Relationship between the tumor and the body].

PMID- 1024300
TI  - [Liver function in acute leukemia].

PMID- 1024301
TI  - [Osmotic resistance of leukocytes and leukolysis in lymphocytic leukemia].

PMID- 1024302
TI  - [Evaluation of polychemotherapy and its complications in late stages of Hodgkin's
      disease].

PMID- 1024303
TI  - [Polychemotherapy of generalized forms of Hodgkin's disease].

PMID- 1024304
TI  - [Leukemoid reaction].

PMID- 1024305
TI  - [Secondary erythrocytosis (classification, pathogenesis and differential
      diagnosis)].

PMID- 1024306
TI  - [Isolation of carotenoid-containing subcellular structures from mollusk nerve
      tissue].
AB  - A subcellular fraction with a high share of carotenoids (about 150 mkg/mg of
      protein) was obtained from the nerve tissue of Lymnaea stagnalis, the
      fractionation being made by sucrose density gradient centrifugation. The quantity
      of carotenoids extracted from fractions was estimated spectrophotometrically. The
      electron microscope observations demonstrated the presence of structures
      analogous to fraction components in the mollusc neurones and similar to some
      kinds of plant chromplasts (carotenoidplasts).

PMID- 1024307
TI  - [Disruption of myofibrils during spreading degeneration. I. Increased Ca2+
      concentration].
AB  - The breakdown of sarcomeres of frog's twitch skeletal muscles during Zenker's
      (spreading) degeneration has been studied. The speed of propagation of the
      destruction process was accelerated by increasing CaCl2 concentration in Ringer's
      solution up to 8mM. An hour after local injury, the fibres were fixed just before
      separation of the next retraction clot or at the stage of granular destruction
      (Fig. 1). The dominating features of the ultrastructure of a fibre at the
      necrotic boundary are the coagulation of small bundles of supercontracted
      myofibrils and breakdown of uncontracted sarcomeres into separate A- and I-bands
      and then into small bundles of A- and I-protofibrils (Fig. 2,3). The same
      breakdown of sarcomers is observed in several small regions at a distance of
      about 100 micron from the necrotic boundary (Fig. 5). Besides this, fusion of a
      few myofibrils followed by the disappearence of M- and Z-bands occurs in the same
      region of the fibre (Fig. 4, 6). The diameter of the majority of myofibrils
      decreases towards the necrotic boundary due to longitudinal splitting and loss of
      peripheral protofibrils, presumably, as a result of lysis (Fig. 7).

PMID- 1024308
TI  - [Modeling changes in the muscle fiber T-system during direct current flow].
AB  - Quantitative calculations of the dynamics of changes in K+, Na+, and Cl-
      concentrations in the T-system (TS) with changeable volume have been made using
      the computer "Dniepr-24". It was assumed that the current is transferred throught
      the TS membrane by K+ and in the lumen of the TS by K+, Na+ and Cl- ions in
      accordance with their mobilities and concentrations. The model predicts the
      accumulation of salt and water in the TS at the site of outgoing current. The
      swelling of TS due to DC effect according to the model was found to be about 9
      and 18% for the current densities of 0.39 X 10(-8) a- cm-2 and 2.34 X 10(-8) a-cm
      2, resp. The model shows that changes in the ion concentration and in the TS
      volume with current densities used experimentally reach a steady-state level. The
      increase of the current by almost 4 times, according to the model, suggests some
      disturbance in the steady-state and in the TS swelling comparable with
      experimental observations of vacuole formation.

PMID- 1024310
TI  - [Cruve of labeled mitoses with different states of cellular proliferation. I.
      Principles of construction for a mathematical model].

PMID- 1024309
TI  - [Effect of weak doses of ethyl alcohol on the resistance of the frog sartorius to
      injurious concentrations of that substance].
AB  - A study was made of the effect of preliminary maintenance of m. sartorius of the
      grass frog in 0.87 M and 1.09 M ethyl alcohol on their resistance to 3.48 M ethyl
      alcohol. The maintenance of muscle tissue in 0.87 M and 1.09 M ethyl alcohol for
      periods, ranging from 15 min. to 2 hours, in different series of experiments led
      to the increase in its resistance to 3.48 M alcohol by 11--24% as compared with
      the initial one. The value of increase in resistance depended on the
      concentration of the agent studied, the duration of maintenance, and of the
      season. A study of non-specificity of the adaptive effect of low alcohol
      decreased their resistance to 0.12 M NaF by 33.3% (P less than 0.05) The same
      concentration of ethyl alcohol applied for periods from 15 mintes to 2 hours
      either caused no change or decreased significantly the resistance of muscle
      tissue to the temperature 36 degrees C. This effect of decrease in resistance was
      even more significant when the resistance to 38 degrees C was challenged. The
      range of individual variability of resistance of muscles to 3.48 M alcohol and 36
      degrees showns that its values in the control and in the experiment are similar.

PMID- 1024311
TI  - [Ovum lipids of placental mammals].
AB  - Morphocytochemical peculiarities of lipids from oocytes of some mammals and man
      were studied. The human oocytes, according to the structure and content of yolk,
      bear a close relation to a hare and a rabbit much differing from gametes of
      predatory animals (dog, cat), artiodactyla (sow), rodents (golden hamster). By
      thin layer chromatography on silicagel, a detailed lipid composition was
      established in the rabbit's oocytes, with neutral lipid and phospholipids
      (kefalin, lecitin, sfingomyelin) dominating. In addition, cholesterin was found.

PMID- 1024312
TI  - [DNA synthesis and mitotic activity in cells of regenerating rat liver following
      x-irradiation in stages GO and Gl].
AB  - Effect of X-rays on DNA synthesis and mitotic activity of regenerating liver
      cells has been studied. The irradiation was performed at a dose of 630 rad before
      hepatectomy and 2.5 and 6 hours after the stimulation of liver. With the
      stimulated liver being irradiated, the number of cells synthetizing DNA and
      entering into mitosis was seen reduced almost twice, whereas DNA synthesis and
      entering into mitosis were delayed, resp., by 4 and 6 hours. Irradiation of liver
      before the stimulation brings about a delay in DNA synthesis and in start of
      mitosis by 2 and 4 hours, resp., without reducing the numbers of cells capable to
      synthesize DNA and to enter mitosis.

PMID- 1024313
TI  - [Mechanism of functional adaptation of intestinal epithelial cells].
AB  - Using preparations of exogenous DNA and products of its in complete degradation,
      the causes leading to the compensatory changes of the share of membrane
      hydrolysus in the total invertase activity of the irradiated rat's intestinal
      epithelial were analysed experimentally. It is shown that the factor stimulating
      the enzyme redistribution towards the brush border zone is not the amount of
      mature villous cells, but the level of mitotic activity in crypts.

PMID- 1024314
TI  - [Effect of preparations of the tuberculin series on a cell culture].

PMID- 1024315
TI  - America's hospitals: what does the future hold?

PMID- 1024316
TI  - Why don't they write about the good things?

PMID- 1024317
TI  - Mandate, maintain, monitor: a model for hospital governance.

PMID- 1024319
TI  - Contract management: is it for your hospital?

PMID- 1024318
TI  - The legal perspective.

PMID- 1024320
TI  - The small hospital under multiple unit management.

PMID- 1024321
TI  - Accelerating the planning and construction process: tips from a developer.

PMID- 1024322
TI  - How to negotiate with consultants and architects.

PMID- 1024323
TI  - Physicians for the future.

PMID- 1024324
TI  - An integrated health service. Recent trends in health service patterns.

PMID- 1024325
TI  - Medical care in an integrated health service.

PMID- 1024326
TI  - A health information system for the management of an integrated health service.

PMID- 1024327
TI  - Integration as a basis for the functioning of health care systems in large areas.

PMID- 1024328
TI  - Medical centres as an institutionalised form of integrated health service.

PMID- 1024329
TI  - An integrated health service. Formation of associations in public health.

PMID- 1024330
TI  - Integration of consumers and providers of health services.

PMID- 1024331
TI  - An integrated health service.

PMID- 1024332
TI  - The application of computer techniques in health care.

PMID- 1024333
TI  - Psychiatry and architecture. The right to normal living conditions.

PMID- 1024334
TI  - Behavioural science and the rationalisation of architectural design.

PMID- 1024335
TI  - Psychiatric architecture and sociotherapy.

PMID- 1024336
TI  - Architecture and psychiatry--what has been achieved?

PMID- 1024337
TI  - Discussion group 3: psychiatry and architecture.

PMID- 1024338
TI  - Control of health care in an uncontrolled environment.

PMID- 1024339
TI  - Rationalising the American health care delivery system: a summary of the health
      planning and resources development act of 1974.

PMID- 1024340
TI  - [Pigment architecture of human cerebral cortex].

PMID- 1024341
TI  - [Origin of greater and smaller pectoral muscles. Experiments with quail and chick
      embryos].

PMID- 1024342
TI  - [Intracellular filaments in anterior cerebral artery endothelium in young rats].

PMID- 1024343
TI  - [Ultrastructure of rat maculae densae after unilateral nephrectomy].

PMID- 1024344
TI  - [Morphometrical growth analysis].

PMID- 1024345
TI  - [Microanalysis of histological tissue sections by extraction and partition
      chromatography (author's transl)].

PMID- 1024346
TI  - [Functional adaptation of exocrine pancreas to long term stimulation in vivo with
      caerulein].

PMID- 1024347
TI  - [Effect of microtubule inhibitors on secreiton process of exocrine pancreas in
      vitro].

PMID- 1024348
TI  - [Place and form of medial cranial fossa foramina].

PMID- 1024349
TI  - [Form development of optic canal, measurements and position with respect to
      cranial bones].

PMID- 1024350
TI  - [Morphometry of articular surfaces of upper head joint (statics of cervico
      occipital transitional region].

PMID- 1024351
TI  - [Accessory skeletal elements].

PMID- 1024352
TI  - [Collateral ligaments in camel knee joint].

PMID- 1024353
TI  - [Mandibular head: anteversion, articular surface and skull curve radius].

PMID- 1024354
TI  - [Determination of articular surface curves].

PMID- 1024355
TI  - [Articular surface form and split-line pattern of talus trochlea].

PMID- 1024356
TI  - [Relationship between bone substance and canal system in diaphyseal compacta of
      some human long bones].

PMID- 1024357
TI  - [Mechanical behavior of parallel-fibred connective tissue at rest or under
      strain].

PMID- 1024358
TI  - [Mechanics and histology of collagen fibers under low strain].

PMID- 1024359
TI  - [Architecture of femur head cartilage by scanning electron microscopy].

PMID- 1024360
TI  - [Changes in synovial membrane ultrastructure after functional load].

PMID- 1024361
TI  - [Densitometric analysis of material distribution in human femoral mid-shaft].

PMID- 1024362
TI  - [Problems of pure homologous articular cartilage transplantation].

PMID- 1024363
TI  - [Transforming processes in autologous articular cartilage transplants. I. Short
      term results].

PMID- 1024364
TI  - [Transforming processes in autologous articular cartilage transplants. II. Long
      term results].

PMID- 1024365
TI  - [Skeletal muscle regeneration].

PMID- 1024366
TI  - [Anatomy of arterial rete mirabile in head region of domestic cat].

PMID- 1024367
TI  - [Anatomy of posterior arch vein of leg and its deep anastomoses Vv. communicantes
      sive perforantes].

PMID- 1024368
TI  - [Observations in occluded arteries].

PMID- 1024369
TI  - [Ultrastructure of isolated rat heart after lanthanum perfusion].

PMID- 1024370
TI  - [Vessel wall structure at origin of mouse intercostal arteries].

PMID- 1024371
TI  - [Vein wall morphology after shunt operation].

PMID- 1024372
TI  - [Ultrastructure of avian renal portal system valve].

PMID- 1024373
TI  - [Scanning electron microscope observations on chick embryo heart bulb cushion].

PMID- 1024374
TI  - [Relationships between endocardial cushion development and hemodynamics in
      embryonic heart. Experimental study on Xenopus laevis larvae].

PMID- 1024375
TI  - [Quantitative analysis of isoproterenol induced rat heart necrosis by point
      counting method].

PMID- 1024376
TI  - [Endothelial structure of pecten vessels in sparrow (Passer domesticus)].

PMID- 1024377
TI  - [Changes in rat kidneys at time of parturition].

PMID- 1024378
TI  - Morphological aspects of the rat kidney during compensatory growth.

PMID- 1024379
TI  - [Cortico-medullary water distribution in rat kidneys during anti- and water
      diuresis].

PMID- 1024380
TI  - [Enzyme histochemical comparison of rat and guinea pig kidney maculae densae].

PMID- 1024381
TI  - [Interactions between blastocyst and endometrium during implantation: Influence
      of blastocyst on endometrial amino acid arylamidase].

PMID- 1024382
TI  - [Differentiation tendency in mesodermal germ layer. Isolation experiments on
      morula, blastula and gastrula stadia of axolotl (Ambystoma mexicanum)].

PMID- 1024383
TI  - [Functional morphology of rat placenta].

PMID- 1024384
TI  - [Trophoblasts of chorionic plate in mature human placenta].

PMID- 1024385
TI  - [Development of tail structures in human spermatids].

PMID- 1024386
TI  - [Morphology and microanalysis of bovine seminal vesicle epithelium].

PMID- 1024387
TI  - [Electron and fluorescence microscopy of human prostate].

PMID- 1024388
TI  - [Development of mammary gland. Histochemical study].

PMID- 1024389
TI  - [Principles of stereology and morphometry presented with large intestinal
      carcinogenesis as example].

PMID- 1024390
TI  - [Error possibilities and error corrections in counting of cells with multiple
      nucleoli].

PMID- 1024391
TI  - [Changes in nuclear structure caused by actinomycin and their registration by
      means of quantitative picture analysis].

PMID- 1024392
TI  - [Application of automatic morphometrical analysis in liver slices of partly
      burned rats].

PMID- 1024393
TI  - [Ultrastructure of so-called ribosome-lamella complex in hairy cell leukemia].

PMID- 1024394
TI  - [Charcot-Leyden crystals in human bone marrow].

PMID- 1024395
TI  - [Behavior of leukocytes towards blood platelets and during retraction].

PMID- 1024396
TI  - [Iron storage and metabolism in nacrophages and endothelial cells after
      intravenous administration of colloidal ferric saccharate in man].

PMID- 1024397
TI  - [Ultrastructure of "feathered" epithelium of pigeon nictitating membrane].

PMID- 1024398
TI  - [Ultrastructure of ring-binding muscle fibers].

PMID- 1024399
TI  - [Ependyma secretion in rat embryo third ventricle].

PMID- 1024400
TI  - [Use of colchamine in complex treatment of laryngeal papillomatosis].

PMID- 1024401
TI  - [Anesthesia and the methods of various micro-operations on the larynx].

PMID- 1024403
TI  - [Basalioma of the left nasal wing].

PMID- 1024402
TI  - [3 cases of metastases of laryngeal cancer into the heart].

PMID- 1024404
TI  - [Esthesioblastoma of the nasal cavity].

PMID- 1024405
TI  - [Esthesioblastoma with bilateral lesion of the nasal cavity].

PMID- 1024406
TI  - [Chondroma of the nose].

PMID- 1024407
TI  - [2 cases of transitional-cell cancer of the nasal accessory sinuses].

PMID- 1024408
TI  - [Pharyngeal lymphangioma].

PMID- 1024409
TI  - [Atypical course of cancer of the palatine tonsils].

PMID- 1024410
TI  - [Congenital tumor of the nasopharynx].

PMID- 1024411
TI  - [Retropharyngeal lipoma].

PMID- 1024412
TI  - [Melanoma of the external auditory meatus].

PMID- 1024413
TI  - [Cancer of the middle ear in a 5-year-old child].

PMID- 1024414
TI  - [Restoration of the laryngeal function after laryngectomy].

PMID- 1024415
TI  - [Supraligamental horizontal resection of the larynx].

PMID- 1024416
TI  - [Pre-epiglottic region - a source of recurrences of laryngeal cancer after
      radiation therapy].

PMID- 1024417
TI  - [Possibilities of vocational rehabilitation after laryngectomy for cancer].

PMID- 1024418
TI  - [Indicators of the reactivity of the body in the evaluation of possible
      malignization of precancerous conditions of the larynx].

PMID- 1024419
TI  - [Nonspecific diseases of the upper respiratory tract and their role in
      precancerous conditions].

PMID- 1024420
TI  - [Polarographic method of examination in the evaluation of the effectiveness of
      treatment of tumors of the upper respiratory tract].

PMID- 1024421
TI  - [Epidemiology of tumors of the upper respiratory tract in various districts of
      the Ukrainian SSR].

PMID- 1024422
TI  - [Combined treatment of chronic hypertrophic laryngitis].

PMID- 1024423
TI  - [Functional state of laryngeal internal muscles in their aseptic inflammation].

PMID- 1024424
TI  - [Selection of the method of treatment of laryngeal cancer].

PMID- 1024425
TI  - [Therapeutic tactics in laryngeal cancer].

PMID- 1024426
TI  - [Prevention of broncho-pulmonary complications after partial or complete
      resection of the larynx].

PMID- 1024427
TI  - [Tumor-like lesions of the upper respiratory tract in pathology of the
      hematopoietic systemy].

PMID- 1024429
TI  - [3 cases of familial laryngeal cancer].

PMID- 1024428
TI  - [Laryngoplasty by means of cervical medial fascia after resection of the larynx
      in cancer].

PMID- 1024430
TI  - [Familial cancer of the larynx].

PMID- 1024431
TI  - [Chondroma of the larynx].

PMID- 1024432
TI  - [Leiomyoma of the larynx].

PMID- 1024433
TI  - [Congenital subplical hemangioma of the larynx and trachea in an infant].

PMID- 1024434
TI  - [Distribution of ABO system blood groups in children with dysentery].

PMID- 1024435
TI  - [Metabolic features of the liver and spleen and antibody formation in animals
      following hyperimmunization with viral antigens].
AB  - Hyperimmunization with the tick encephalitis and Western horse encephalomyelitis
      viruses reproduced in the brain of albino mice, intensified the protein synthesis
      in the splenic tissue during the productive phase of the immunogenesis (the 7th
      day). An accumalation of protein, activation of aniuno-acyl-t-RNA-ligases, a
      reduction of the concehtration of some amino acids was noted, An analogous
      reaction was distinct in the tissue of the liver only when an intact brain
      suspension was used as an antigen. Formation of specific antibodies coursed more
      intensively after the administration of a more pathogenic virusof Western equine
      encephalomyelitis.

PMID- 1024436
TI  - [Several physiologic features of the body and their role in the process of
      vaccination against measles].
AB  - The work was carried out under conditions of mass measles immunization at the
      polyclincs of Moscow and Dushanbe. The role of the macroorganism at the time of
      vaccination on the measles vaccination process was investigated. A thorough study
      of the anamnesis, its allergic predisposition was conducted; blood and C-RB were
      examined, and the content of serum immunoglobulins was determined by Macini's
      method. The results obtained pointed to the insufficiently complete detection of
      children with an altered reactivity by a simple examination by the physician
      alone. It was revealed that children suffering from various forms of allergy
      having in the anamnesis hypotrophy rickets and frequent acute respiratory
      diseases and chronic foci of infections had decreased indice of nonsecific
      immunological reactivity even at the period of clinical well-being, and could be
      detected only by means of laboratory methods of study. To the administration of
      measles vaccine such children responded not only by the development of clinical
      reactions of different intensity, but also by a significant reduction of antibody
      formation. All the aforesaid indicates a necessity of further study of the
      mechanism of establishment of postvaccinal measles immunity with consideration to
      the individual reactivity of the child organism.

PMID- 1024437
TI  - [Virulence of strains of Staphylococcus aureus isolated from neuro-oncologic
      patients in the pre-operative and postoperative periods].

PMID- 1024438
TI  - [Comparative assessment of 2 methods of determining the fibrinolytic activity of
      microorganisma].

PMID- 1024439
TI  - [Immunologic effectiveness of brucella chemical vaccine in volunteers].

PMID- 1024440
TI  - [Current findings concerning the molecular structure of Cl. botulinum types E and
      F].

PMID- 1024441
TI  - [Quality and effectiveness of anti-epidemic labors].

PMID- 1024442
TI  - [Role of the lysozyme-like enzyme of staphylococci in their pathogenicity].
AB  - Observations of the authors of the present work permit to put forward the
      following suppositions on the biological significance of the lysozyme sign
      included into the number of sign-of the staphylococcus pathogenicity: 1) the
      action of the lysozyme-like enzyme (LLE) as a facs for increasing the
      permeability of the cell wall and thus promoting the exit of the "pathogenicity
      enzymes"; 2) its participation in the growth and division of staphylococci,
      pointing to the differences in the rate of the growth of the cultures forming and
      nonforming the LLE; 3) participation of the LLE in the microbial antagonism
      processes--crude LLE (in the form of lipoproteid complex) stipulated the
      antimicrobial effect against a number of nonpathogenic microbes. None of these
      hypotheses can be accepted without further investigations, particularly with the
      purified enzyme.

PMID- 1024443
TI  - [Production of extracellular plasmocoagulase in staphylococcus aureus exposed to
      3,6-diaminoacridines].
AB  - A modified quantitative nephelometric method was used. It was shown that
      production of extracellular plasmocoagulase was depressed in the development of
      acridine-sensitive and acridine-resistant cultures of Staph. aureus in the fluid
      nutrient medium containing 3,6-diaminoacridines: acriflavine, proflavine,
      acridine yellow, acridine orange, acridine No. 40 and acridine No. 56; 3,6
      diaminoacridines failed to lead to noncompetitive inhibition of staphylococcus
      plasmocoagulase. A disturbance of the regulation of the enzyme exit into the
      external environment can serve as the cause of depression of the extracellular
      plasmocoagulase production by Staph. aureus.

PMID- 1024444
TI  - [Histopathology and histochemistry of a focus of staphylococcal infection in a
      sensitized body (material concerning pathogenesis)].
AB  - Rabbits were sensitized with a killed St. aureus culture (alpha-toxigenic 0-15
      strain); one week later the  were infected intradermally with a virulent
      leukocidin-active St. aureus V8 or with the 0-15 strain. A hyperegic inflammation
      with the signs of reaction observed in hypersensitivity of delayed type was
      revealed at the site of infection in 24 hours. On the seond day this process was
      supervened by an intensive leukocytic infiltration characteristic of this
      infection, with the subsequent suppuration. Beginning from the earliest stages of
      the process and up to its decline the inflammatory exudate displayed hyaluronic
      and sialic acids; they could perform functions of the nonspecific immunity
      factors in the focus. It was revealed at the terminal stage of the process that
      the organism did not react by the inflammatory reaction to the presence of the
      microbes remaining near the focus. Consequently, the tolerance of the organism to
      the microbe was revealed; this tolerance was possibly conditioned by the presence
      of sialic acids in the focus. Leukocytes with the phagocytized microbes appeared
      in the veins nearest to the focus. Histochemical shifts in the focus can be the
      cause of the incompleteness of phagocytosis. The tropism of staphylococci of the
      V8 strain to the collagen fibers was revealed.

PMID- 1024445
TI  - [Experimental cholera in guinea pigs. II. Pathogenesis of experimental
      infection].
AB  - It was found by bacteriological, anatomo-pathological and histological studies
      that intrapulmonary administration to guinea pigs of a suspension of the cholera
      causative agent containing colloidal substances (peptone, gelatine, agar-agar)
      caused primary reproduction of vibrios in the pulmonary tissue and the pleural
      exudate. From the lungs the microbes penetrated by hematogenic route into the
      liver and the bile system and with the flow of the infected bile entered the
      small intestine. Intestinal affection by the type of specific enteritis developed
      as a result of intensive vibrio reproduction in the submucous layer.

PMID- 1024446
TI  - [Long-term survival of E1 Tor cholera vibrios in naturally contaminated sewage].
AB  - El Tor cholera vibrios of Ogava serological type were revealed in the sewage of
      the locomotive shed for 15 months. In experiment with an oil catcher in naturally
      infected sewage El Tor vibrios survived 36 days, in storage of this sewage at the
      laboratory--39 days, in the artificially infected sewage of a settlement and of a
      milk plant--2 and 11 days, respectively, in the oil and disel fuel--14 months.
      Consequently, El Tor vibrio can survive in the sewage with a high oil product
      content for a long time.

PMID- 1024447
TI  - [Phage typing of cholera vibrios with different sets of phages].
AB  - A comparative study was made of two sets of Mukerjee and Drozhevkina-Arutyunova's
      bacteriophages in typing 514 strains of the El Tor vibrios and 45 strains of
      clasic biotype. It was shown that the Mukerjee or Drozhevkina-Arutyunova's phages
      could be used for the typing of cholera vibrios. The phages of the latter set
      prove to detect more phage types (18 against 11); they determine both the phage
      type and the biotype at the same time. The typing of cholera vibrios of both
      biotypes is possible, and the percentage of nontyping strains left is
      comparatively low (5.2 against 23.5 after Mukerjee). A table of the phage
      correspondence was made; it permits to obtain comparable data in using any set of
      the typing phages.

PMID- 1024448
TI  - [Synthesis of messenger-like RNA in plasma cels producing different clases of
      immunoglobulins].
AB  - Electrophoretic analysis of the nuclear poly A RNA cells of the MOPC 21, MOPC 406
      and MOPC 41 plasmocytomas demonstrated a similarity in their distribution by the
      mol wt. Kinetics of the label accumulation in the nuclear poly A RNA of different
      plasma cells was unitypical. Individual peculiarities of the distribution of the
      cytoplasmic poly A RNA were expressed for each individual line of the myeloma
      cells. The majority of the molecules of the heterogenous RNA in the plasma cells
      were subjected to posttranscription polyadenylation.

PMID- 1024449
TI  - [Target cell production of substances modifying the degree of their lysis by
      immune lymphocytes and macrophages].

PMID- 1024450
TI  - [Relationship between blocking the erythrocyte surface and the quantity of IgG
      molecules bound in the process of hemosensitization].
AB  - Under different conditions of the IgG-sensitization of the tannin-treated
      erythrocytes a determination was made of the degree of blocking the cell surface.
      There was shown a reverse relationship between the amount of the bound IgG
      molecules and their portions bound by the surface with the maximal cross-section.
      Fixation of the IgG by means of CH2O at the end of sensitization led to the
      additional blocking of the erythrocyte surface. The limit of the erythrocyte
      saturation with the IgG molecules was controlled by the greatest possible density
      of the globulin molecules localization.

PMID- 1024451
TI  - [Reactogenicity and immunologic effectiveness of cholerogen-anatoxin. Feasibility
      of revaccination with cholerogen-anatoxin, determination of optimal doses and
      times for administration].
AB  - The authors discussed the results of study of the titre of vibration antibodies
      and antitoxins one, three and five months after the vaccination of adults with an
      optimal vaccination dose of cholerogen toxoid (24OO BU). Comparison of the
      immunological information obtained at the above mentioned periods showed the
      expediency of revaccination three months after the vaccination. Immunogenicity of
      the three doses of the cholerogen-toxoid tested (1200, 2400, 3600 BU) displayed
      no statistically significant difference in revaccination. Taking into
      consideration that the least reactogenic dose was 1200 BU this dose is
      recommended as the optimal revaccination dose for adults.

PMID- 1024452
TI  - Participation of the thymus in the mechanism of bacterial discharge in carriers
      of typhoid bacteria.
AB  - Typhoid carrier state was reproduced in 54 rabbits by the injection of typhoid
      bacilli into the bone marrow of the femoral bone. The animals were divided into 3
      groups. Those in the 1st and 2nd group were hydrocortisone and ATC before the
      infection, respectively, whereas the 3rd group served as control. The data
      obtained pointed to the great incidence of prolonged persistence of typhoid
      bacilli in the bone marrow. A much greater vital disharge of the causative agent
      with the feces was noted in the animals which before the infection were given
      hydrocortisone and ATC preparations depressing the functional activity of the
      thymus. In the second experimental series it was shown that ATC administration to
      rabbits on the 85th day after their intraosseous infection with typhoid bacilli
      promoted vital discharge of the causative agent with the feces. Problem of
      participation of the thymus in the mechanism of bacterial discharge in the
      carriers of typhoid bacilli are discussed.

PMID- 1024453
TI  - A simple, cheap, effective and safe procedure for general anesthesia.
AB  - A simplified, safe and flexible technique of anesthesia, based on a limited
      number of relatively cheap drugs, and allowing ventilation with air, was applied
      to 60 patients undergoing operations of at least 60 minutes' duration. The
      required depth of hypnosis was produced by intravenous diazepam or gamma-OH,
      whilst droperidol and fentanyl provided a satisfactory degree of sedation and
      analgesia. Pancuronium bromide was used for muscle relaxation. Spontaneous
      respiration was resumed immediately after postoperative use of nalorphine and
      neostigmine. The anesthetic course was smooth and predictable, with
      cardiovascular stability and an uneventful postoperative recovery. Emphasis is
      laid on the suitability of this procedure on the Battle Field or in Developing
      Countries, and on its safety (no toxic volatile liquids). (Acta anaesth. belg.,
      1976, 27, 25-34).

PMID- 1024454
TI  - Central anticholinergic syndrome in anesthetic practice.
AB  - Anticholinergic agents may lead to a syndrome described by Longo as the Central
      Anticholinergic Syndrome (CAS). Patients with this syndrome exhibit one or more
      of the following: though impairement, disturbance of recent memory,
      hallucinations, ataxia, excitement, drowsiness of coma. We have reviewed our use
      of anticholinergics and tried to correlate it with the occurrence of the above
      symptomatology and have treated 200 cases in which the CAS was diagnosed with
      physostigmine salicylate (0.04 mg/kg). We also successfully treated 2 cases of
      apparently central anticholinergic hyperpyrexia in the same way. We would suggest
      that physostigmine be included in the armamentarium of every anesthetist to
      combat anticholinergic poisoning by the wide range of presently used
      anticholinergic drugs. (Act anaesth. belg., 1976, 27, 45-60).

PMID- 1024455
TI  - Data processing and anesthesia in a large university hospital.

PMID- 1024456
TI  - [Genetic study of mani-depressive psychoses].
AB  - The aim of the present work is to investigate the heredity of manic-depressive
      syndromes, in particular to test the hypothesis of a dominant X-linked
      transmission in these disorders. The Maximum Likelihood Estimate method was
      applied to linkage analysis between several X-linked genetic markers and bipolar
      manic-depressive illness, as well as to a control population of unipolar
      depressive patients. The genetic markers studied were deuteranopia and protanopia
      (two X-linked recessive markers) and the Xg blood group (X-linked dominant
      marker). The sampling methods were identical for both groups of patients and the
      family studies were performed "blind" (i,e. without knowledge of the proband's
      diagnosis). The results demonstrate the presence of strong linkage between manic
      depressive (bipolar) illness, deuteranopia and protanopia. Linkage (although less
      strong) was also shown for bipolar illness and the Xg blood group. The genetic
      data are based on mathematical analysis of 36 informative kindreds ascertained
      from a sample of 134 manic-depressive patients. The results are concordant and
      demonstrate that, in this sample, manic-depressive (biopolar) psychosis is
      genetically transmitted through a X-linked dominant factor. We have also
      demonstrated the absence of linkage between unipolar depressive illness and the
      studied genetic markers in 16 informative kndreds ascertained from a sample of 71
      unipolar patients. The genetic analyses described in this study demonstrate the
      existence of a manic-depressive syndrome which phenotype is dominant and
      determined by a gene located on the short arm of the Xchromosome. Apart from some
      forms of mental deficiency, manic-depressive psychosis represents the first known
      instance of a mendelian heredity machanism in psychiatric disorder;

PMID- 1024457
TI  - Respiratory neurons of the ventral respiratory nucleus of the rabbit and their
      vagal connections.
AB  - The pattern of firing and responses to electrical stimulation of the ipsilateral
      vagus nerve were studied in respiratory neurons near the nucleus ambiguus (NA) in
      the region called "ventral respiratory nucleus". In 41 (out of 77) respiratory
      neurons orthodromic responses were recorded; the remaining neurons did not
      respond to stimulation. It is concluded that the NA neurons of the rabbit are not
      laryngeal motoneurons. Moreover, the short-latency excitatory response of some of
      these neurons, and long-latency inhibition of the other, suggest that NA neurons
      may be involved in the processing of vagal information.

PMID- 1024458
TI  - Significance of cranial circulation for the brain homeothermia in rabbits. I. The
      brain-arterial blood temperature gradient.
AB  - The hypothalamic-arterial blood temperature gradient (THpr-TAC difference) was
      studied on 10 freely moving rabbits at ambient temperatures between 0 and 42
      degrees Celsius. In cold environment, below 10 degrees Celsius the THpt-TAC
      gradient varied considerably, but some distinct correlations were found between
      vasomotor responses of the nasal mucosa and fluctuations of brain temperature, as
      well as between vasomotor responses of the ear pinnas and changes of the arterial
      blood temperature. Vasodilatation of the nasal mucosa or the ear pinna caused
      respectively a drop in brain temperature or in arterial blood temperature.
      Opposite changes were induced by vasoconstriction in those areas. Variations in
      THpt-TAC gradient resulted from oppositely directed vasomotor responses in the
      nasal mucosa and in the ear pinnas. At high ambient temperatures above 35 degrees
      Celsius thermal panting was accompanied by selective brain cooling with respect
      to the arterial blood. Blocking the heat loss from the nasal mucosa caused an
      increase of the THpt-TAC difference, and under these conditions brain temperature
      was determined solely by arterial blood temperature. The assumed mechanism of the
      selective brain cooling in rabbits is the exchange of heat through the
      neurocranial bottom, between the ventral brain and the spacious splanchnocranial
      venous lakes supplied with blood from the nasal mucosa.

PMID- 1024459
TI  - Significance of cranial circulation for the brain homeothermia in rabbits. II.
      The role of the cranial venous lakes in the defence against hyperthermia.
AB  - Chronic experiments were conducted on five freely moving rabbits at ambient
      temperatures of 0-42 degrees Celsius. The influence of nasal mucosal thermal
      changes on the venous blood temperature inside the pterygoid plexus and on the
      temperatures at three intracerebral sites were investigated against the
      background of the carotid arterial blood temperature shifts. A correlation was
      found between: (i) the fluctuations in the nasal mucosal temperature reflecting
      its vasomotor responses, (ii) temperature shifts of the pterygoid plexus venous
      blood, and (iii) of the ventral brain. Mucosal vasodilatation caused parallel
      drops in both the plexal blood and brain temperatures. However, mucosal
      vasoconstriction was accompanied by increases in temperatures at those sites.
      Intracranial thermal shifts were independent of the arterial blood temperature
      changes. During motor activity in normothermia nasal mucosal vasoconstriction was
      present, and in that case brain temperatures exceeded arterial blood temperature.
      During rest, mucosal vasodilatation appeared and brain base cooled below the
      arterial blood temperature. During panting in dry heat, the brain base was cooler
      than the arterial blood by as much as 0.5 degree Celsius. The intensity of the
      selective brain cooling was directly proportional to deep body temperature. The
      blockade of the respiratory evaporation in heat elicited an increase of the
      plexal venous blood as well as brain temperatures above the arterial blood
      temperature. We conclude that the venous blood outflowing from the nasal mucosa
      exerts a cooling influence on the brain through the pterygoid plexus.

PMID- 1024460
TI  - Electrical stimulation of the hippocampus and acquisition of the conditioned
      avoidance response in shuttle-box in cats.
AB  - The effects of electrical stimulation and electrolytic lesions of the posterior
      part of the hippocampus on acquisition of the active avoidance response (AAR) in
      shuttle-box were studied in 35 cats. Both weak or strong hippocampal stimulation
      applied simultaneously with conditioned stimulus (CS) facilitated the acquisition
      of AAR. After discontinuation of stimulation the level of AAR performance in
      response to CS alone decreased in cats trained with the use of strong
      stimulation. However, if the stimulation was applied before each experimental
      session the level of AAR performance did not differ from that observed during the
      final phase of training. These changes of AAR were not observed in cats trained
      with the use of weak stimulation. The application of hippocampal stimulation
      alone did not evoke AAR in shuttle-box after training independently of
      stimulation parameters. There were no differences in the speed of AAR acquisition
      between unoperated cats, implanted controls and cats with lesions in the
      posterior part of the hippocampus.

PMID- 1024461
TI  - Effects of electrical hippocampal stimulation on acquisition and performance of
      unidirectional active avoidance response in cats.
AB  - The influence of electrical stimulation of the posterior part of the hippocampus
      on acquisition and performance of the conditioned, unidirectional avoidance
      response was investigated in 26 cats. No significant differences in the speed of
      learning between stimulated and control animals were observed. However,
      electrical hippocampal stimulation with parameters 7/s, 100 microamps, 7/s, 200
      microamps and 50/s, 100 microamps (1 ms square pulses of negative polarity)
      facilitated the performance of the avoidance response. Strong hippocampal
      stimulation (50/s, 200 microamps) caused inhibitory effects. Application of
      hippocampal stimulation before experimental sessions increased the performance
      level in comparison to sessions not preceded by hippocampal stimulation.

PMID- 1024462
TI  - Instrumental reactions and food and water intake in medial amygdala rats.
AB  - Rats were trained preoperatively to perform instrumental reactions for food and
      water reward on a continuous reinforcement schedule. Two levers on two opposite
      sides of the Skinner box were available. Each press of the first lever delivered
      one drop of water and each press of the second lever - one pellet of solid food.
      After the electrolytic lesions of the medial part of the amygdaloid complex, rats
      were hypophagic and hypodipsic. Most of the animals showed, however, only small
      decreases of total unconditioned daily water and food intake. On the other hand,
      the instrumental performance was markedly impaired, in particular for water
      reinforcement. Histological verification showed that lesions were restricted to
      the amygdaloid complex and involved mainly the ventral part of medial nucleus.

PMID- 1024463
TI  - Effects of binocular deprivation of pattern vision on single unit responses in
      the cat superior colliculus.
AB  - Single unit responses in the superior colliculus of cats deprived of pattern
      vision from birth and of normally reared cats were studied in unanesthetized
      pretrigeminal preparations. Collicular units of deprived cats showed a diminished
      direction-selectivity but a somewhat better speed-selectivity compared to
      normals; they also preferred lowspeed stimuli, and reacted less frequently to
      diffuse flash. The impairment of direction-selectivity of collicular neurons may
      be partly responsible for the impairment of the pursuit eye movements in visually
      deprived cats.

PMID- 1024464
TI  - Hemispheric differences in the visual analysis of the verbal and non-verbal
      material in children.
AB  - Five years old children, who could not read, and the same children at the aged of
      7, who already knew letters, were used as subjects. A visual procedure involved
      presentation of single letters or a pair of letters randomly to the left or right
      of a central fixation point. Reaction time and number of correct identifications,
      showed by pressing a key, were indicators of the perception of letters. The
      children of five identified the letters with equal correctness, whether they were
      addressed to the right or to the left hemisphere, whereas the children of seven
      showed left hemisphere superiority.

PMID- 1024465
TI  - John C. Leonard Award address.

PMID- 1024466
TI  - Preparing teachers of family practice education.

PMID- 1024467
TI  - Planning CME programs that fit staff interests: patient-problem inventory.

PMID- 1024469
TI  - Continuing education for competency in the smaller community hospital.

PMID- 1024468
TI  - Functions and responsibilities of the Liaison Committee on Graduate Medical
      Education.

PMID- 1024470
TI  - Experiences with dopamine in patients operated with the aid of extracorporeal
      circulation.
AB  - In ten patients dopamine was used for counteracting low cardiac output during and
      after operations performed with aid of extracorporeal circulation. The changes of
      arterial and venous pressure, heart rate and one-hour diuresis were measured. In
      8 cases the results of treatment were good. Particularly striking was the
      improvement of diuresis and lowering of the central venous pressure. The authors
      regard dopamine as a very effective inotropic agent.

PMID- 1024471
TI  - Enflurane in anaesthesiological practice.
AB  - Enflurane was given as the principal inhalatory agent in general anaesthesia in
      75 patients aged from 17 to 55 years for gynaecological operations. Anaesthesia
      was conducted with muscle relaxation administering the drug in concentration of
      0.2-1% vol. (mean maintenance concentration 0.6%). No cardiovascular, hepatic and
      renal disturbances were observed. The serum glucose level increased by a mean
      value of 64.8% during enflurance anaesthesia, however, it did not cross the renal
      threshold. Enflurane failed to ensure postoperative analgesia. The drug may be
      used as a valuable supplement to the presently used anaesthetic agents.

PMID- 1024472
TI  - Certain parameters of pulmonary circulation dynamics and gas exchange in the
      lungs and morphotic changes in lung tissue in dogs during cardiac arrest and
      immediately after resuscitation.
AB  - The experiments were carried out in 33 dogs 60 min. to 12 hours after cardiac
      arrest was induced for 3-5 min by ventricular fibrillation. In 11 dogs closed
      chest cardiac massage was performed 30 min. and in 222 dogs defibrillation was
      used to restore heart function. The pulmonary and peripheral circulation was
      assessed on the basis of changes in arterial and venous blood pressure, cardiac
      output, vascular resistance, pulmonary shunting and capnographic determinations.
      The values of VA, VA/Vmin, V/Q, VDph, VD/VT, DuO2 and DuCO2, Pa-E'CO2, PaO2 were
      determined. Measurements of acid base balance, lactate and pyruvate levels and
      certain elements of blood clotting and fibrinolysis systems were performed.
      Moreover, lung biopsy was examined by light and electron microscopes. Functional
      determinations confirmed the presence of disturbances of lung perfusion and
      alveolar ventilation as well as disturbances in oxygen exchange at cellular
      level. The author suggests the term Resuscitation Lung Syndrome for these
      disturbances.

PMID- 1024473
TI  - The effect of bone cement used for stabilization of endoprostheses on blood
      clotting system activity.
AB  - The authors carried out studies of the blood clotting and fibrinolysis systems in
      15 patients undergoing total endoprosthetic replacement of the hip joint with a
      McKee-Ferrara type of prosthesis and stabilized by Surgical Simplex Acrylic bone
      cement (North Hill Plastics, Ltd. London). The observations point to
      statistically significant changes in the blood clotting and fibrinolysis systems
      with a tendency towards hypercoagulation and intravascular clotting (DIC).
      Fibrinolysis activation associated with these changes is secondary, resulting
      among others, from the mechanism of the action of free fibrin monomers.

PMID- 1024474
TI  - An attempt at comparing the results of carboxyhaemoglobin level in blood and
      gasometric determinations in capillary blood in cases of carbon monoxide
      poisoning when treatment began at the place of accident.
AB  - The authors observed disturbances of acid-base equilibrium and levels of
      carboxyhaemoglobin in 116 cases of CO intoxication. The patients were treated
      early -- at the place of the accident and during transport to hospital. Oxygen
      treatment was applied, the acid-base equilibrium disturbances were corrected,
      especially the metabolic acidosis by using alkaline substances. This management
      enabled rapid elimination of the poison from the organism and an improvement in
      the general condition of the patients.

PMID- 1024475
TI  - Acute life endangering ethanol intoxication treated in the intensive medical care
      unit.
AB  - Personal observations of 5 cases of acute life-endangering ethanol intoxication
      who were treated in the intensive medical care unit. The authors discuss the
      mechanism of ethanol-induced changes and the method used in the treatment of this
      intoxication. They also request that hospital laboratories should provide
      facilities for performing blood alcohol level determinations in emergencies.

PMID- 1024476
TI  - Electric stimulation in chronic headaches.
AB  - Therapeutic electric stimulation in cases of chronic headaches was carried out in
      150 patients. Migraine was diagnosed in 40 cases, common vasomotor headache in
      63, cervical migraine in 24, Horton's neuralgia in 5 and complex headaches in 18
      cases. The results are reported here, which were best in the cervical migraine
      syndrome, while in the typical migraine they were the least successful.

PMID- 1024477
TI  - [Primary carcinomas and carcinomatous disease].
AB  - The occurence rate of multiple primary tumours is assessed differently by
      different authors (from 0.3 to 8%). Simultaneous plurality is seen essentially in
      a system of the same structure. It is nevertheless often difficult to distinguish
      a new and second or third tumour from metastases of the first. The articel
      analyses the statistics obtained in a series of 288 cases of malignant "primo
      plural" neoplasms appearing successively.

PMID- 1024478
TI  - [An audiometric method for use with children. The cochleo-palpebral reflex can be
      improved by visual conditioning].
AB  - It is possible, even with children and new-born babies, to condition the oculo
      palpebral reflex to respond to sound. The apparatus constructed by Messrs.
      Gasquet and Brun achieves this conditioning on the one hand and, on the other,
      allows this to be used as a method of visual audiometry. This method generally
      enables the operator to come within twenty decibels or so of the real threshold
      compared with the unconditioned cochleo-palpebral reflex threshold. The use of a
      polygraphic recording technique for palpebral response adds precision to the
      results of this method, particularly by the demonstration of a phenomenon of
      anticipation which appears when the conditioning has been achieved. Audiometry by
      means of conditioning therefore represents an objective technique for detecting
      deafness in new-born babies.

PMID- 1024479
TI  - [The mechanism and consequences of certain cranio-facial injuries].
AB  - The authors present the mechanism of post-traumatic lesions of the bones of the
      cranio-facial mass, during attention to the possibility of radiographic detection
      6 or 9 days after traumatism.

PMID- 1024480
TI  - [A case of post-traumatic cholesteatoma].
AB  - The author published a case of cholesteatoma of the middle ear occurring a few
      months after head injury with fracture of the mastoid apophysis.

PMID- 1024481
TI  - [The trans-cochlear approach to the skull base].

PMID- 1024482
TI  - Effects of cold-shock on blood cells in a fresh water tropical teleost, Colisa
      fasciatus.
AB  - Immersion of the adult female fresh water tropical teleost, Colisa fasciatus, in
      ice water at c. 2 degrees C for one minute immobilizes the fish. It, however,
      recovers within two minutes when returned to warm temperature. Hematological
      studies at recovery time intervals, viz., 3, 15 and 27 min and, later, at
      intervals of 48 min up to 363 min, and at 12 and 24 h, revealed significant
      changes in the abundance of leucocytes and thrombocytes: an increase in the
      number of leucocytes (leucocytosis) was evident from 15 through 123 min and at
      267 min; normal leucocyte counts, were observed at 3, 171, 219, 315 and 363 min,
      and at 12 h and 24 h. Lymphocytes are the major leucocyte cell type in the blood.
      Thrombocytopenia occurred at 15 and 27 min, and thrombocyte counts were held at
      normal levels at other recovery time intervals. There was no change in the
      abundance of erythrocytes in response to the imposed stress. Shock susceptibility
      of the fish for variables measured was similar in experiments performed during
      six different months of one calendar year. In addition, no significant seasonal
      or diurnal changes were recorded in the abundance of circulating blood cells. The
      results reported here, for the first time on a tropical teleost, do not agree
      with previous results obtained from temperate teleosts by other workers.

PMID- 1024483
TI  - [The degenerating processes of germinal cells during oogenesis in Lithobius
      forticatus L. (Myriapoda chilopoda)].
AB  - The ovary of Lithobius forficatus always contains some degenerating oocytes. The
      cytologic evolution during the oocyte degenerescence is described. Cytoplasmic
      lysis takes place before nuclear lysis and the vitellinic reserves resist the
      longest. The degenerates coming from previtellogenetic or poorly vitellogenetic
      cells are essentially recovered by the follicular cells. If large vitellogenetic
      or mature oocytes are affected, their vitellinic reserves are released into the
      ovarian cavity and included in the cells of the ovarian epithelium. The number of
      degenerating oocytes is in relation with the external conditions; it reaches a
      maximum at the end of the spring. The temperature may act directly or indirectly
      through the endocrine centers.

PMID- 1024484
TI  - [Vitellogenesis in decapod cephalopods: evolution of oocytes and follicular cells
      during genital maturation].
AB  - The investigation was carried out on two Cephalopods: Sepia officinalis and
      Loligo vulgaris. During previtellogenesis, the follicle cells (F.C.), originally
      arranged at the periphery of the oocyte, form strands, through the axis of which
      runs a blood vessel. The follicle strands then make their way down into the
      ooplasm. They end up by occuping the greater part of the volume of the oocyte. At
      this stage, despite their increase in size, the F.C. do not undergo conspicuous
      cytological transformations. In the ooplasm, excepting a few specialized
      structures (annulate lamellae), the organites display no notable differentiation.
      The onset of vitellogenesis is characterized by the appearance in the ooplasm of
      elements paracrystalline in structure. A zona pellucida appears between the
      oocyte and the F.C., and it is at the point that yolk of a permanent type begins
      to accumulate. Concurrently the F.C. undergo characteristic reorganization:
      hypertrophy of the nucleolar mass, multiplication of granular reticulum
      cisternae, increase both in the number and the size of the Golgi complexes. The
      saccules of the Golgi complex process a material rich in carbohydrate protein
      bearing the same cytochemical characteristics as the yolk. In the basal zone of
      the F.C., deep invaginations of the wall of blood vessels scallop the cytoplasm.
      F.C. look like "podocyte cells". Immunofluorescence study suggest there is no
      immunological identity between blood and yolk proteins. The formation of chorion
      is accompanied by a fresh transformation of the F.C.: the granular endoplasmic
      reticulum breaks up into rounded cisternae containing a dense material.
      Concurrently the morphology of the Golgi complex is modified. The earliest
      chorion elements accumulate, firstly in the forme of isolated lobules within the
      zona pellucida. They then fuse to make a continous layer bounding the microvilli
      of the F.C. These cells eventually enter into a phase of degeneration and
      disappear, whilst the oocyte is set free by dehiscence into coelomic cavity.

PMID- 1024485
TI  - [Quantitative studies on the regeneration of myelinated nerve fibers. I.
      Variations in the number and the size of myelinated fibers in the nerves of
      normal rats].
AB  - The number and size of myelinated nerve fibers have been determined at standard
      levels in the nerve to medial head of right and left gastrocnemius muscles of 24
      normal rats (11 males and 13 females). The mean values of all results were
      comparable on right and left sides. Thus, 271 +/- 5 myelinated nerve fibers were
      found in the right nerve and 272 +/- 4 in the left; their mean diameter were
      respectively 8.1 +/- 0.1 and 8.0 +/- 0.1 micron. There were 60.1% of large nerve
      fibers on the right side and 59,9% on the left, their mean diameters being 10.5
      and 10.6 micron. Some variations occured in all these values, depending of the
      weight and sex of the animals. Nevertheless, the differences between both sides
      of a same rat were negligible and the histograms of both nerves could be
      superposed. Accordingly, in the operated animals, the contralateral nerve may be
      used as control.

PMID- 1024486
TI  - [Daignostic value of cytology in endometrial cancer (author's transl)].

PMID- 1024487
TI  - [Cytodiagnosis of lesions of the vulva (author's transl)].

PMID- 1024488
TI  - [Cytology of the pouch of Douglas in carcinoma of the endometrium (author's
      transl)].

PMID- 1024489
TI  - Gravlee-Gavlee.

PMID- 1024490
TI  - [Analysis of 144 spermocytograms (author's transl)].

PMID- 1024491
TI  - [Critical study of 1,000 coelomic serous effusions (author's transl)].

PMID- 1024492
TI  - [Results of 83,621 cytopathologic examinations of cervico-vaginal smears].

PMID- 1024493
TI  - [Detection of cervico-uterine cancer].

PMID- 1024494
TI  - Hodgkin's disease: an evaluation of radiotherapy results.

PMID- 1024495
TI  - The radiological features of cerebral torulosis.

PMID- 1024496
TI  - Anomalous origin of the left vertebral artery and its significance in selective
      femoro-cerebral catheterisation.

PMID- 1024497
TI  - Amyloidosis causing right middle lobe atelectasis.

PMID- 1024498
TI  - The accuracy of the barium meal in the diagnosis of carcinoma of the stomach.

PMID- 1024499
TI  - Bolus intravenous injection of contrast and sequential opacification in the
      diagnosis of pelvic masses.

PMID- 1024500
TI  - Roentgen interpretation of ureteral deviation.

PMID- 1024501
TI  - Coeliac-axis artery stenosis with aneurysmal calcification of the collateral
      supply.

PMID- 1024502
TI  - Forearm bone destruction in leprosy.

PMID- 1024503
TI  - Osteoporosis circumscripta cranii: its importance in brain scintiscanning.

PMID- 1024505
TI  - Polycystic spleen -- an unusual cause of a left hypochondrial mass.

PMID- 1024504
TI  - Clinical investigation on splenic aneurysms and Gamna-Gandy nodules.

PMID- 1024506
TI  - Further aspects of angiographic brain death.

PMID- 1024507
TI  - Whole body scanning with 67Ga in the investigation of patients with lymphomas and
      suspected lymphomas.

PMID- 1024508
TI  - Contamination incidents resulting from the use of a 99Mo-99mTc generator.

PMID- 1024509
TI  - Tc(Sn) gluconate -- a species dependent radiopharmaceutical.

PMID- 1024510
TI  - Gel permeation chromatography.

PMID- 1024511
TI  - [Recent biologically-active synthetic 2-indolinones].

PMID- 1024512
TI  - [Tests of container-content cession of pharmaceutical preparations in plastic
      containers].

PMID- 1024514
TI  - Mass spectra of some intermediate compounds for the synthesis of prostaglandins.

PMID- 1024513
TI  - [Fentiazac in arthritis due to sodium urate].

PMID- 1024516
TI  - [Considerations on "Study of contamination and products of degradation in the
      development of drugs"].

PMID- 1024515
TI  - [Analysis by means of ion exchange chromatography of phosphate derivatives of
      inosine].

PMID- 1024517
TI  - The role and the mode of action of the lubricants in tablets manufacturing.

PMID- 1024518
TI  - [Separation, identification and determination of hydrogenated derivatives of
      Claviceps pupurea by means of high-speed liquid chromatography].

PMID- 1024519
TI  - [Relationship between the structure and metabolic ways in tricyclic compounds].

PMID- 1024520
TI  - [Gas chromatographic determination of organic solvents as air pollutants].

PMID- 1024521
TI  - [Stability of hydrosoluble salt of acetylsalicylic acid].

PMID- 1024522
TI  - [Experimental studies on the autoregulation of regional pancreatic circulation.
      Effect of intramural peripheral venous stimulation. 1. Influence of 2-(N-p-tolyl
      N-m-hydroxyphenyl-aminomethyl) imidazoline (Regitine)].

PMID- 1024523
TI  - [Experimental studies on the autoregulation of regional pancreatic circulation.
      Effect of intramural peripheral venous stimulation. 3. Influence of 2-octahydro-1
      azocinyl-ethylguanidine sulfate (guanethidine)].

PMID- 1024524
TI  - [Influence of metabolic acidosis and alkalosis on the biosynthesis of lipids in
      the rat brain].

PMID- 1024525
TI  - [Cytometric data on epidermal cells of Sempervivum tectorum L. leaves at various
      growth levels].

PMID- 1024526
TI  - [Effects of various drugs on experimental ulcer in the rat].

PMID- 1024527
TI  - Effects of some autonomic drugs on the electrical activity of intestinal circular
      muscle.

PMID- 1024528
TI  - [Acid-base equilibrium and enzymes in cerebral lipid metabolism].

PMID- 1024529
TI  - [Effects of experimental surgical traumas on the acid-base equilibrium in the
      albino rats treated with various anesthetics].

PMID- 1024530
TI  - [Reciprocal transversal junctions between 2 lateral geniculate bodies].

PMID- 1024531
TI  - [Hydratation and dehydratation effects on protein synthesis and respiration in
      vivo in wheat embryos and seeds].

PMID- 1024532
TI  - [Morphologic changes in the liver of C57BL-DBA2 homoparabiotic mice].

PMID- 1024533
TI  - [Alkaline degradation of selenocysteine].

PMID- 1024534
TI  - [Experimental studies on the autoregulation of the regional circulation of the
      pancreas. Effect of peripheral venous intramural stimulation. (7) Influence of 5
      hydroxytryptamine].

PMID- 1024535
TI  - [Experimental studies on the autoregulation of the regional circulation of the
      pancreas. Effect of peripheral venous intramural stimulation. (8) Influence of
      bradykinin].

PMID- 1024536
TI  - [Experimental studies on the autoregulation of the regional circulation of the
      pancreas. Effect of peripheral venous intramural stimulation. (9) Influence of
      eledoisin].

PMID- 1024537
TI  - [Anion translocation in mitochondria. II. Transport of dicarboxylic and
      tricarboxylic acids].

PMID- 1024538
TI  - [Effect of N-ethylmaleimide and butylmalonate on the energy-dependent respiration
      of rat liver mitochondria].

PMID- 1024539
TI  - [Studies of the enzyme, poly A polymerase, from rat liver mitochondria].

PMID- 1024540
TI  - [Personality variability: physiological and behavioral parameters. (I). Body
      image, personality dimensions (Eysenck schema) and autonomic index (Kerdoe
      schema)].

PMID- 1024541
TI  - [Personality variability: physiological and behavioral parameters. (2). Cognitive
      style and personality dimensions].

PMID- 1024542
TI  - [Personality variability: physiological and behavioral parameters. (3). Anxiety:
      psychometric exploration and autonomic response].

PMID- 1024543
TI  - [Behavior of various enzymes in muscle fibers after stimulation with neurotrophic
      substances. I. Enzymes of carbohydrate metabolism].

PMID- 1024544
TI  - [Rapid method of isolation of chick-embryo synaptosomes: morphological analysis
      of the fractions].

PMID- 1024545
TI  - [Retrograde conduction of the impulse in ventricular tachycardia and its
      hemodynamic significance].

PMID- 1024546
TI  - [Anaerobic glycolysis in the lung of the chick embryo and in chickens a few days
      old].

PMID- 1024547
TI  - [Effect of purine nucleotides on thirst and diuresis].

PMID- 1024548
TI  - [Bidimensional immunoelectrophoresis of serum lipoproteins. Note on methodology].

PMID- 1024549
TI  - [Possibilities of the use of bidimensional immunoelectrophoresis in the study of
      the plasma components of the arterial wall. Note on methodology].

PMID- 1024550
TI  - [Microbiological study with cyclacillin].

PMID- 1024551
TI  - [Study of the action of combinations of beta-lactam antibiotics on the beta
      lactamase produced by strains of Enterobacteriaceae].

PMID- 1024552
TI  - [Study of the microbiological activity in vitro of BB-K-8, a new aminoglycoside
      antibiotic].

PMID- 1024553
TI  - Hemispheric differences in discriminative reaction time to facial expressions:
      preliminary observations.

PMID- 1024554
TI  - [Behavioral study of the nature of the inhibition between the superior colliculi
      in the cat].

PMID- 1024555
TI  - [Hemispheric differences in discrimination of the speed of motion].

PMID- 1024556
TI  - [Experimental studies of laboratory animals intubated with colza and canbra
      oils].

PMID- 1024557
TI  - [Our experience with the use of a radioisotope technic for the study of gastric
      emptying].

PMID- 1024558
TI  - [Simple and reproducible technic for G bands on human chromosomes].

PMID- 1024559
TI  - [Changes in pectolytic activity with Aspergillus niger incubated at various
      temperatures].

PMID- 1024560
TI  - [The blood-medullary barrier in the bursa of Fabricius].

PMID- 1024561
TI  - [Recent studies on supernumerary ribs. Theory concerning their morphogenesis and
      proposed classification].

PMID- 1024562
TI  - [Sex chromatin behavior during phases of the menstrual cycle].

PMID- 1024563
TI  - [Semiquantitative evaluation of leukocyte acid phosphatase].

PMID- 1024564
TI  - [Effects of N-acetylaspartic acid and N-acetylaspartylglutamic acid by
      iontophoretic administration, on some structures of the neuraxis in rats].

PMID- 1024565
TI  - [Changes in the bioelectric activity of the rat brain induced with glutamate].

PMID- 1024566
TI  - [Selective hepatic hypothermia in the swine. I: Problems of surgical technics].

PMID- 1024567
TI  - [Evaluation of adrenal cortex function in the aged using gas chromatography of
      urinary steroids].

PMID- 1024568
TI  - [Effects of the treatment with an antiestrogen(tamoxifen) and levodopa on the
      secretion of prolactin in patients affected by breast cancer].

PMID- 1024569
TI  - [FDP in normal and pathologic pregnancy].

PMID- 1024570
TI  - [Plasma levels of free and total tryptophan during a course of attack
      hemicrania].

PMID- 1024571
TI  - [Urinary kallikrein in acute hepatitis and liver cirrhosis].

PMID- 1024572
TI  - [Effect of mercury on the development or ova in the sea hedgehog. I].

PMID- 1024573
TI  - [Effect of lead on the development of ova in the sea hedgehog. II].

PMID- 1024574
TI  - [In vitro formation of se-sulfo-cysteamine coupled for transamination and
      oxidative deamination of cysteine-sulfinic acid].

PMID- 1024575
TI  - [Effects of vinblastine and vincristine on the in-vitro response to sympathetic
      stimulation (peripheral nerve and receptor)].

PMID- 1024576
TI  - [Structural organization of chromatin (review of new data)].

PMID- 1024577
TI  - [Light-induced redox conversions of cytochrome f in pea leaves].
AB  - Redox conversions of cytochrome f were studied in intact pea leaves by double
      wavelength difference spectrophotometry. Using the inhibition of the photosystem
      II activity by far red light (719 nm) or diurone, it was found that cytochrome f
      is located between two photosystems on the oxidative side of photosystem I. The
      inhibitors of phosphorylation, , e.g. antimycin A and phloridzine, as well as the
      uncoupler, methylamine, strongly decreased electron transport through the
      carrier. It is concluded that cytochrome f is functioning in the non-cyclic
      phosphorylation. It is suggested that in vivo cytochrome f is not coupled with
      cyclic electron transfer.

PMID- 1024578
TI  - [Amino acid sequence in tryptic peptides of maleylated Micrococcus sp. n.
      histidine decarboxylase beta-polypeptide chain].
AB  - Maleilated histidine decarboxylase beta-polypeptide chain, containing 3 arginine
      residue, was hydrolysed by trypsin. 4 non-overlapping homogenous peptides were
      isolated, 3 of them containing one arginine residue and the 4th peptide being C
      terminal fragment of beta-chain. beta-Polypeptide chain is found to consist of 78
      amino acid residues and to have molecular weight of 8456. Primary structure of
      each peptide and their possible sequence in beta-chain are determined.

PMID- 1024579
TI  - [Effect of monovalent cations on glutamate metabolism in rat brain].
AB  - Glutamate oxidation in vitro via deamination and transamination during gramicidin
      C-induced transport of K+ and Na+ in rat nervous tissue mitochondria was studied.
      An increase in ammonium production, i.e. in glutamate oxidation due to
      deamination, was shown to occur with maximal increase of oxygen consumption in
      the presence of cations. It was found that 1.5 mM Na+ activate oxygen consumption
      by 15% and accelerate ammonium production from glutamate (by 17%). No changes in
      aspartate production were observed. 15 mM K+ increase oxygen consumption by 29%
      and ammonium production by 11% during a decrease in aspartate production as
      compared to glutamate oxidation in the presence of a lower (10 mM) concentration
      of K+ in the samples.

PMID- 1024580
TI  - [The pentose phosphate pathway and NADP-dependent glycerol-3-phosphate
      dehydrogenase activity in some tissues of albino rat].
AB  - The NADP-dependent glycerol-3-phosphate dehydrogenase activity in liver, heart
      and skeletal muscle of rat was studied. The activity is found when glyceraldehyde
      3-phosphate or ribose-5-phosphate in the presence of ATP are taken as substrates.
      The data obtained confirm that NADP-dependent glycerol-3-phosphate dehydrogenase
      exists in skeletal muscle and demonstrate that it is found in heart muscle as
      well.

PMID- 1024581
TI  - [Stabilization of polyacrylamide gel immobilized horseradish peroxidase by its
      covalent coupling to albumin].
AB  - Pretreatment of peroxidase by its covalent coupling to inert proteins and albumin
      by means of glutaraldehyde considerably increases the thermostability and
      specific activity of polyacrylamide gel (PAAG) immobilized peroxidase. The
      effects of PAAG composition on the catalytic properties of the immobilized
      oligomers: peroxidase-inert proteins-albumin, are studied. The oligomers
      immobilized in 40% PAAG (10% N,N'-methylenebisacrylamide) possess the maximal
      specific activity (4.5 nmol/g). The effects of oligomer composition on their
      catalytic activity and stability in PAAG are studied. The stability of oligomers
      of optimal composition (ratio of albumin/peroxidase is 2.4), incorporated into
      40% PAAG, is 15 times higher as compared to that of the soluble enzyme and 250
      times higher as compared to that of the enzyme incorporated into PAAG without
      pretreatment. A mechanism of stabilizing effect exerted by albumin on peroxidase
      in PAAG-immobilized oligomers, is discussed.

PMID- 1024582
TI  - [Lipid peroxidation and disturbance in Ca2+ transport through sarcoplasmic
      reticulum membranes during E-avitaminosis].
AB  - The antioxidant effect of alpha-tocopherol in biolgoical membranes in vivo is
      described. Experimental E-avitaminosis is accompanied by accumulation of products
      of free-radical oxidation of phospholipids and by a loss of Ca2+-transporting
      ability of the muscle cells microsomal fraction. The role of alpha-tocopherol in
      stabilization and as a "radical trap" in biological membranes is discussed.

PMID- 1024583
TI  - [Isotopic effect in enzymatic oxidation of methane].
AB  - The isotopic effect during oxidation of methane and deuteromethane by a
      suspension of Methylomonas rubrum cells, for which methane is the only source of
      carbon, was observed. The rate of CH4 oxidation is 12.5 times higher than that of
      CH4 oxidation. It is demonstrated that CD4 is a competitive inhibitor of CH4
      oxidation. The results obtained suggest that the disruption of the C-H bond is
      the limiting step of enzymatic oxidation of methane.

PMID- 1024584
TI  - [Preservation of differences in the degree of polymerization of actin, isolated
      at different stages of ontogenesis after its purification].
AB  - Actin preparation from skeletal muscles of new-born, 10 days old and adult
      rabbits, containing less than or equal to 5% of inactivated actin and 1-2% of
      other myofibrillar proteins, were studied by means of flow birefringence and
      viscosimetry. It is found, that, like earlier studied crude preparations,
      purified actin preparations, isolated at different ontogenesis stages, differ in
      their intrinsic viscosity and extinction angle. These differences retain after
      the additional trypsin treatment. Non-polymerizing fraction of Straub F-actins,
      isolated from rabbit muscles of all ontogenesis stages studied, practically does
      not affect the polymerization in the course of ontogenesis, which is due to
      changes in its stucture.

PMID- 1024585
TI  - [Purification and properties of plastocyanin and ferredoxin from Ceratophyllum
      demersum L].
AB  - A copper-containing protein plastocyanin and iron-containing protein ferredoxin
      were isolated in electrophoretically homogenous states from Ceratophyllum
      demersum L. Molecular weights, protein compositions as well as optical and EDP
      specta of both proteins are presented. The proteins studied showed considerable
      differences in ultraviolet spectrum and amino acid composition as compared to
      analogous proteins from surface higher plants and green algae.

PMID- 1024586
TI  - [Nature of tryptophan photooxidation products in lysozyme in the presence of
      methylene blue].
AB  - One out of six trytophan residues in two lysozyme modification, obtained under
      lysozyme photooxidation in the presence of methylene blue, is found to be
      oxidized to N'-formylkinurenine (in one modification) and to kinurenine (in the
      other modification). The transition of one modification into another via
      detaching of N'-formyl group by soft acid hydrolysis has shown that one and the
      same tryptophan residue is oxidized in both products, Possible mechanism of
      tryptophan oxidation to the products mentioned is discu-sed on the basis of the
      hypothesis on signlet mechanism of lysozyme photooxidation in the presence of
      methylene blue.

PMID- 1024587
TI  - [Purification and properties of hydrogenase from phototrophic bacterium Thiocapsa
      roseopersicina].
AB  - The isolation method and some peoperties of purple sulphur bacteria (Thiocapsa
      roseopersicina strain BBS) hydrogenase are described Hydrogenase molecular weight
      is found to be 66000; it contains 3.7 moles of S2- and 3.9 moles of Fe2+ per one
      mole of the enzyme;pI=4.2. The enzyme absorption spectrum has the maximum at 400
      412 nm which is characteristic of proteins containing non-haem iron. Hydrogenase
      is suggested to consist pf 4 subunits of two types: with molar weight 27000 and
      6000. Unlike other hydrogenases, this enzyme is rather resistant to O2 and is
      more thermostable: the inactivation of the enzyme was observed at the temperature
      above 80 degrees C; Hydrogenase preparation catalyses D2-H2O exchange reaction,
      H2 evolution from the reduced methyl viologene (MV) and H2 absorption in the
      presense of MV or benzylviologene but not in the presense of NAD(P), FAD, FMN,
      azocarmine, methylene blue and ferricyanide.

PMID- 1024588
TI  - [Nature of the effect on RNA and substrate specificity of RNAase of Bacillus
      amylozyma 9a].
AB  - Extracellular RNAase from Bac. amylozyma 9a has endonucleolytic character of the
      action on RNA, it splits in RNA 5'-phosphodiester bonds of GpXp type (where X is
      any nucleoside). The hydrolysis proceeds in two steps by the intramolecular
      transphosphorylation type of reaction to form guanosine-2',3'-phosphates and with
      the subsequent hydrolysis of cyclic bonds. The enzyme shows a preferable
      specificity to the single-stranded structure of the polyribonucleotides.

PMID- 1024589
TI  - [Interaction of adenine derivatives with chloroplast membranes].
AB  - Structural changes of chloroplast fragments result in increased adsorption of
      adenine derivatives. The nativity of membranes is essential for AMP adsorption.
      Chloroplast fragments, containing CF1, adsorb adenine and adenosine by 30% and
      ADP by 50% more than the fragments, devoid of the enzyme. It is assumed that
      lipids may act as sorbents during nucleotides interaction with the chloroplast
      membrane.

PMID- 1024590
TI  - [Effect of thiol reagents on the interaction of glutamate dehydrogenase with sex
      hormones].
AB  - The blocking of glutamate dehydrogenase SH-groups with some thiol reagents
      decreases the binding of sex hormones and the degree of their inhibitory effect
      on glutamate dehydrogenase activity.

PMID- 1024591
TI  - [Role of e-propione amide group of the corrine macrocycle in the manifestation of
      coenzyme properties of the cobamide coenzyme].

PMID- 1024592
TI  - [Isolation and purification of NADP-dependent "L-malate"-enzyme from corn
      leaves].
AB  - Isolation and purification of "malic-enzyme" NADP was done using fractionation by
      ammonium sulfate, anion-exchange chromatography on DEAE cellulose, gel-filtration
      through Sephadex G-200 and purification on DEAE Sephadex A-50. The isoenzyme
      isolated had a specific activity of 40-50 mkM/mg protein per min (approximately
      80-fold purification) and contained negligible admixtures.

PMID- 1024593
TI  - [Study of amino acid composition and biosynthesis of protein components of the
      membrane system of corn plastids during biogenesis of chloroplasts].
AB  - The biosynthesis of membrane proteins in maize plastids at different stages of
      differentiation of the chloroplast lamellar system was studied. Prolamellar and
      lamellar system preparations were isolated from maize plastids, disintegrated by
      osmotic shock under hypotonic conditions. Changes in the amino acid composition
      of 14C membrane proteins were observed at all stages of chloroplast
      ultrastructure formation. The maximal level of the apolar amino acids was
      observed in the membrane fraction of chloroplasts. Washed membranes from maize
      proplastids and chloroplasts can be resolved into at least 14 protein bands on
      formic acid--urea polyacrylamide gel. It is pointed out that biogenesis process
      leads to the increase of lipophylic protein content in the chloroplast lamellae
      fraction.

PMID- 1024594
TI  - [Important role of C-terminal amino acid sequence of the luteinizing hormone
      alpha-subunit in its recombination with the beta-subunit].
AB  - Five amino acid residues, i. e. serine, lysine, histidine and two tyrosine
      residues, are split from the C-end of the alpha-subunit of bovine luteinizing
      hormone by carboxypeptidase A. Gel-filtration through Sephadex G-100 demonstrated
      that the carboxypeptidase-treated alpha-subunit is not recombined with the native
      beta-subunit and does not form complex molecules of the hormone.

PMID- 1024595
TI  - [Bacteriochlorophyll fluorescence changes related to the bacteriopheophytin
      photoreduction in the chromatophores of purple sulfur bacteria].
AB  - It is shown that illumination of chromatophores of sulfur bacterium Chromatium
      minutissimum at Eh of the medium --200 mV divided by --620 mV (when the
      photooxidation of pigment P890 is completely inhibited) induces a decrease in
      bacteriochlorophyll fluorescence yield, reversible in the dark. Under these
      conditions a reversible photoreduction of bacteriopheophytin is detected
      (bleaching of absorption bands at 543 and 760 nm and development of a band at 650
      nm), which is accompanied by a blue shift of the absorption band at 8 nm. As a
      possible interpretation of these effects the suggestion is made on the function
      of bacteriopheophytin as a primary electron acceptor in reaction centers of
      bacteria. The bacteriopheophytin photoreduction, followed by a decrease in
      fluorescence yield, is also observed in other sulfur bacteria, Thiocapsa
      roseopersicina and Ectothiorodospira shaposhnikovii, but it is not detected in
      nonsulfur bacteria, Rhodospirillum rubrum and Rhodopseudomonas spheroides. This
      is considered as an evidence for the difference in the functional organization of
      the reaction centers of these two groups of bacteria,

PMID- 1024596
TI  - [18 O-exchange reactions catalyzed by subfragment 1 of myosin molecule].
AB  - 18 O-exchange properties of enzymically active proteolytic fragment of myosin
      molecule--subfragment 1 were studied. It was shown that 18O-exchange activity of
      subfragment 1 is similar to that of parental myosin and its other proteolytic
      fragment--heavy meromyosin. The experimental data suggest that the 18O-exchange
      activity is an integral property of myosin and is not determined by its
      contaminations.

PMID- 1024597
TI  - [Effect of synthetic tetradecapeptide corresponding to 31-44 amino acid sequence
      of growth hormone on lipolysis in human adipose tissue].
AB  - Fat mobilyzing activity of synthetic tetradecapeptide, which corresponds in 31-
      44 amino acid sequence of human growth hormone, is studied in vitro in human fat
      tissue. The peptide at concentrations of 3--33 microng/ml considerably stimulated
      lipolysis in subdermal fat tissue, omentum and shoulder ateroma. Minimal
      efficient peptide concentration was 3 microng/ml in most experiments, sometimes
      it was 0.3 microng/ml. Direct dependency between dose logarithm and lipolysis
      rate was observed at dose interval of 0.3--18 microng/ml. Native growth hormone
      produced no activity in human fat tissue even in concentrations of 50--100
      microng/ml.

PMID- 1024598
TI  - [Bacteriophage T2 DNA modification by O-methylhydroxylamine].
AB  - A comparative study of the reactivities of free 5-hydroxymethylcytosine (5-HMC)
      and 5-HMC found in the composition of native, denaturated and intraphage DNA of
      the T2 phage with that of O-methylhydroxylamine (OMHA) demonstrated that the DNA
      secondary structure in situ is partially disturbed. The interaction DNA-protein
      in the phage particle channels the reaction into a predominant formation of 4N
      methoxy-6-methoxyamino-5,6-dihydro-5-hydroxymethyl cytosine, but not 4N-methoxy-5
      hydroxymethyl cytosine, which is formed in vitro. In the course of the reaction
      the interaction DNA-protein is probably fixed by covalent binding.

PMID- 1024599
TI  - [Properties and reaction mechanism of mitochondrial menadione reductase].
AB  - An isolation procedure of mitochondrial menadione reductase from rat liver using
      an ethanol-ether extraction for solubilization of the enzyme is described. The
      enzyme was purified 930-fold. The molecular weight of mitochondrial menadione
      reductase is 62,000. According to spectroscopic and enzymic analysis the
      prosthetic group of the enzyme was identified as FAD. Mitochondrial menadione
      reductase is inhibitied by dicumarol and p-chloromecuribenzoate. The enzyme is
      characterized by a group substrate specificity towards quinones. A high catalytic
      activity of menadione reductase towards 4-aniline-5-methoxy-1,2-benzoquinone
      (AMOBQ), and 4-N-(p-sulfoanilino)-5-methoxy-1,2-benzoquinone (AMOBQS) as
      acceptors was demonstrated. It was shown that the reduction of these orto
      benzoquinones by NAD(P) H follows the "ping-pong" kinetics. The kinetic constants
      for NAD(P)H,AMOBQ and and AMOBQS were determined.

PMID- 1024600
TI  - Regional assignments of the genes for fumarate hydratase and guanylate kinase on
      chromosome 1 and for lysosomal acid phosphatase and esterase A4 on chromosome 11.

PMID- 1024601
TI  - Localization of the structural locus for cytoplasmic glutamic-oxaloacetic
      transaminase to region q24 leads to qter of human chromosome 10.

PMID- 1024602
TI  - A preliminary analysis of the segregation of human hydroxyacyl coenzyme A
      dehydrogenase in human-mouse somatic cell hybrids.

PMID- 1024603
TI  - Assignemnt of a gene for tryptophanyl-transfer ribonucleic acid synthetase to
      human chromosome 14.

PMID- 1024604
TI  - Assignment of the locus determining inorganic pyrophosphatase to chromosome 10 in
      man.

PMID- 1024605
TI  - Assignment and linear order of human acid phosphatase-2, esterase A4, and lactate
      dehydrogenase A genes on chromosome 11.

PMID- 1024606
TI  - Retinoblastoma and chromosome 13.

PMID- 1024607
TI  - Radiation-induced segregation of syntenic loci: a new approach to human gene
      mapping.

PMID- 1024608
TI  - Identification of a de novo chromosome rearrangement in a man-mouse hybrid clone
      and its bearing on the cytological map of the human X chromosome.

PMID- 1024609
TI  - Localization of GOTs to the q24 leads to qter region of human chromosome 10.

PMID- 1024610
TI  - Mapping the locus of the H-Y antigen.

PMID- 1024611
TI  - Assignment of the human genes for mannose phosphate isomerase, pyruvate kinase
      (M2), and hexosaminidase-A to chromosome 15.

PMID- 1024612
TI  - Assignment of hexosaminidase-B to chromosome 5, its segregation after diphtheria
      toxin selection, and the linkage of hexosaminidase-A, mannose phosphate
      isomerase, and pyruvate kinase (M2).

PMID- 1024613
TI  - Expression of human hexosaminidase-A phenotype depends on genes assigned to
      chromosomes 5 and 15.

PMID- 1024614
TI  - Assignment of the inorganic chromosome 10 in man.

PMID- 1024615
TI  - Assignment of the peptidase D gene locus (PEPD) to chromosome 19 in man.

PMID- 1024616
TI  - Further data on the cytologic mapping of the human X chromosome with man-mouse
      cell hybrids.

PMID- 1024617
TI  - Assignment of the human gene for tryptophanyl-tRNA synthetase using human-mouse
      somatic cell hybrids.

PMID- 1024618
TI  - Assignment of the human alpha-l-fucosidase gene locus to chromosome 1 by use of a
      "clone panel".

PMID- 1024619
TI  - Report of the committee on the genetic constitution of chromosome 6.

PMID- 1024620
TI  - Segregation of human mitochondrial thymidine thymidine kinase activity in human
      mouse somatic cell hybrids.

PMID- 1024621
TI  - Gene mapping by exclusion: the current status.

PMID- 1024622
TI  - Linkage studies on familial hyperlipoproteinemia with xanthomatosis: normal
      lipoprotein markers and the C3 polymorphism.

PMID- 1024623
TI  - Possible linkage between the Marinesco-Sjogren syndrome and hypergonadotropic
      hypogonadism.

PMID- 1024624
TI  - Linkage data on 3q11 and 15ps fluorescence markers.

PMID- 1024625
TI  - Red cell glutathione reductase activity in patients with bone-marrow trisomy 8.

PMID- 1024626
TI  - The Colton blood groups in monosomy 7 of the bone marrow.

PMID- 1024627
TI  - The interpretation of lods in linkage analysis.

PMID- 1024628
TI  - Probable linkage between essential familial hypercholesterolemia and third
      complement component (C3).

PMID- 1024629
TI  - Chido blood group and the HLA region.

PMID- 1024630
TI  - Rodgers blood group and the HLA region.

PMID- 1024631
TI  - Gene linkage studies on glyoxalase I.

PMID- 1024632
TI  - A genetic linkage analysis of chromosome 6 markers Chido, HLA, and glyoxalase.

PMID- 1024633
TI  - Further evidence for the assignment of the red cell acid phosphatase gene (ACP1)
      to the short arm of chromosome 2 from gene dosage effect.

PMID- 1024634
TI  - The locus for glyoxalase I (GLO) is between HLA-A and PGM3 on chromosome 6 of
      man.

PMID- 1024635
TI  - Chromosome 6: linkage of the eighth component of complement (C8) to the
      histocompatibility region (HLA).

PMID- 1024636
TI  - Linkage group I: the simultaneous estimation of recombination and interference.

PMID- 1024637
TI  - Some lod scores concerning chromosome 1.

PMID- 1024638
TI  - Bf locus and the HLA region.

PMID- 1024639
TI  - The linkage and mapping relationships of 1qh.

PMID- 1024640
TI  - Family studies on esterase D and chromosome 13 in man.

PMID- 1024641
TI  - A report on a family with a (1;2) translocation: cytologic and linkage analysis.

PMID- 1024642
TI  - Genetic linkage of a locus for erythrocyte glyoxalase (GLO) with HLA and Bf.

PMID- 1024643
TI  - Unreliability of the microcomplement fixation method for Xga typing of cultured
      fibroblasts.

PMID- 1024644
TI  - Human gene locations achieved by means of human-Chinese hamster (CHO-K1)
      auxotrophic cell hybridization.

PMID- 1024645
TI  - Chromosomal gene transfer: prospects of a new method for mapping closely linked
      human genes.

PMID- 1024646
TI  - Expression of human X-chromosomal markers in man-Chinese hamster hybrids treated
      with isolated human chromosomes.

PMID- 1024647
TI  - Mapping of genes and adenovirus-12-induced gaps using chimpanzee-mouse somatic
      cell hybrids.

PMID- 1024648
TI  - Chimpanzee gene mapping.

PMID- 1024649
TI  - Gene mapping by somatic cell hybridization in species other than man.

PMID- 1024650
TI  - Clues to homologous regions in mammalian autosomes.

PMID- 1024651
TI  - Comparative gene mapping of HPRT, G6PD, and PGK in man, mouse, and muntjac deer.

PMID- 1024652
TI  - The location of RN5S genes on the chromosomes of primates.

PMID- 1024653
TI  - Report of the committee on the genetic constitution of the X and Y chromosomes.

PMID- 1024654
TI  - Report of the committee on unassigned linkage groups.

PMID- 1024655
TI  - Report of the committee on nomenclature.

PMID- 1024656
TI  - Report of the committee on the genetic constitution of chromosomes 1 and 2.

PMID- 1024657
TI  - Report of the committee on comparative mapping.

PMID- 1024658
TI  - Proposed banding nomenclature for the Chinese hamster chromosomes (Cricetulus
      grises).

PMID- 1024659
TI  - Assignment of the genes for human glyoxalase I to chromosome 6 and for human
      esterase D to chromosome 13.

PMID- 1024660
TI  - The gene for the species antigen on human chromosome 11 is on the short arm.

PMID- 1024661
TI  - Regional mapping of the X-linked gene for a human cell surface antigen, SA-X.

PMID- 1024662
TI  - A guarded word of welcome.

PMID- 1024663
TI  - The crisis of custody: how a psychiatrist can be of help.

PMID- 1024664
TI  - Johnnie and Suzie, don't cry: Mommy and Daddy aren't that way.

PMID- 1024665
TI  - Custody proceedings: battlefield or peace conference?

PMID- 1024666
TI  - Legal implications of behavior modification programs.

PMID- 1024667
TI  - The devil's advocate.

PMID- 1024668
TI  - Federated Council for Internal Medicine. Position papers on the internist and
      primary care.

PMID- 1024669
TI  - Critical implications of National Health Insurance.

PMID- 1024670
TI  - Viewpoint: health manpower.

PMID- 1024671
TI  - Government looks at clinical competence.

PMID- 1024672
TI  - College Life Plan has several options.

PMID- 1024673
TI  - Preliminary information on antimicrobial study is ready.

PMID- 1024674
TI  - Society looks at clinical competence.

PMID- 1024675
TI  - Medical liability: update.

PMID- 1024676
TI  - Insurance premiums and taxes.

PMID- 1024677
TI  - Federated Council for Internal Medicine: position on an integrated health
      manpower policy for primary care.

PMID- 1024678
TI  - Cryosurgery in removal of orbital tumors.
AB  - Two cases in which medially placed retro-orbital tumors were approached
      transfrontally have been presented. The computerized tomographic scanner was
      important in the localization of both lesions. Although of different histologic
      types, both tumors were friable and vascular. This friability and vascularity
      would have caused severe difficulties in removal had it not been for the facility
      with which a cryoprobe froze and grasped tumor tissue. The importance of this
      instrument, previously unemphasized, has been pointed out.

PMID- 1024679
TI  - An autopsy case of the Dandy-Walker syndrome.

PMID- 1024680
TI  - Alteration of calcium metabolism in chronic pancreatitis.

PMID- 1024681
TI  - A scanning electron microscopic study of rat liver sinusoids.

PMID- 1024682
TI  - An autopsy case of carcino-sarcoma of the liver.

PMID- 1024683
TI  - [Atrophine mydriasis of relaxation and surrounding illumination].

PMID- 1024684
TI  - [Visual conditions in unilateral uncorrected aphakic circulation].

PMID- 1024685
TI  - [Treatment of resistant congenital obstruction of the lacrimal pathways].

PMID- 1024686
TI  - [Statistical study of vascular pseudo papillitis].

PMID- 1024687
TI  - Intraocular pressure rise and secondary degeneration of the optic pathway.

PMID- 1024688
TI  - [Results in the surgical treatment of endocrine ophthalmoplegia].

PMID- 1024689
TI  - Occlusion of the central retinal vein: revealing symptom of intraocular pressure
      rise.

PMID- 1024690
TI  - Essential tremor in Papua, New Guinea.
AB  - The clinical features of 175 cases of essential tremor are related. This disorder
      is prevalent among a population of the Eastern Highlands of Papua New Guinea. It
      affects predominantly women in middle and old age; only 27 per cent of the cases
      were males. The disorder is slowly progressive and significant disability appears
      in elderly women when the trunk muscles are involved. Epidemiological studies
      have shown that the presence of tremor can be correlated with linguistic
      distinctions between high and low prevalence populations. Although only 30
      patients reported a first degree relative with tremor, the syndrome would seem to
      stem from a genetic predisposition. In a number of patients essential tremor
      appeared to be associated with Parkinson's disease.

PMID- 1024691
TI  - The diagnosis of congenital unilateral third-nerve palsy.
AB  - Sixteen cases of congenital unilateral third-nerve palsies collected from the
      records of the Wilmer Eye Institute and The Johns Hopkins Hospital over twenty
      one years are reviewed. Their aetiology, clinical features, differential
      diagnosis and prognosis are discussed. Their benign nature with respect to
      absence of associated neurological disease and the high probability of their
      causing amblyopia and aberrant regeneration are emphasized.

PMID- 1024692
TI  - The state of the speciality.

PMID- 1024693
TI  - Defence mechanisms in middle childhood.

PMID- 1024694
TI  - Pre-senile dementia presenting as a depressive illness. A case report.

PMID- 1024695
TI  - Medicolegal aspects of transsexualism.

PMID- 1024696
TI  - Treatment of drug-induced psychosis with diphenylhydantoin.

PMID- 1024697
TI  - Suicide and prevention centres.

PMID- 1024698
TI  - Lynching : a psychiatrist's view.

PMID- 1024699
TI  - [Cancerization of peptic ulcer and coincidence of peptic ulcer with stomach
      cancer in persons deceased at higher age groups].

PMID- 1024700
TI  - [Assessment of potential malignity of intestinal polyps (author's transl)].

PMID- 1024701
TI  - [Rare case of massive choledocholithiasis, complete obliteration of the papilla
      vateri and concomitant cholecystoduodenal fistula (author's transl)].

PMID- 1024702
TI  - [Methods of vagotomy, operation technique and complemental operations in the
      therapy of gastroduodenal ulcers (author's translation)].

PMID- 1024703
TI  - [Vagotomy in the management of duodenal ulcers].

PMID- 1024704
TI  - [The differential diagnosis of otosclerosis].

PMID- 1024705
TI  - [Traumatic paralyses of the facial nerve].

PMID- 1024706
TI  - [Iatrogenic paralyses of the facial nerve].

PMID- 1024707
TI  - [Localization and content of alkaline and acid phosphatases in the cochlea in
      experimetnal diabetes].

PMID- 1024708
TI  - [Naso-orbital fractures: contribution to their diagnosis and surgical therapy].

PMID- 1024709
TI  - [Problems of controversial clinical and histopathological findings in the
      diagnosis of laryngeal cancer].

PMID- 1024710
TI  - [Hemorrhage in laryngeal neoplasms].

PMID- 1024711
TI  - [The problem of second primary or late relapsing laryngeal cancers].

PMID- 1024712
TI  - [Phonal radiological picture of the esophagus after laryngectomy and after
      treatment of the defect using Messerklinger's method as modified by semczuk].

PMID- 1024713
TI  - [Lipomas and lipomatoses of the salivary glands].

PMID- 1024714
TI  - Serological survey of arbovirus infection in Sri Lanka.

PMID- 1024715
TI  - Empyema thoracis in infancy and childhood.

PMID- 1024716
TI  - The cardinal features of the ten-year national health plan of the Republic of
      Zambia.

PMID- 1024717
TI  - The clinical presentation of trap-gun injuries.

PMID- 1024718
TI  - Meningococcal septicaemia.

PMID- 1024719
TI  - Transitional cell papilloma of the nose with malignant termination.

PMID- 1024720
TI  - Acute respiratory distress following nitrofurantion therapy.

PMID- 1024721
TI  - Laboratory diagnosis of syphilis.

PMID- 1024722
TI  - Murugesar Sinnatamby oration 1974. Obstetric and gynaecologic complications
      associated with a bicornuate uterus.

PMID- 1024723
TI  - [Influence of the environment on the prevalence of AgHBs in Senegal].

PMID- 1024724
TI  - [Contribution to the study of cerebro-spinal meningitis in Niger].

PMID- 1024725
TI  - [Effects of administration of a combination sulfadoxine-pyrimethamine on attacks
      of malaria in hyperendemic zones].

PMID- 1024726
TI  - [Significance of cytodiagnosis in dermatology].

PMID- 1024727
TI  - [Meningitis due to Moraxella (apropos of 6 cases)].

PMID- 1024728
TI  - [Localization of placenta by a radio-element].

PMID- 1024729
TI  - [Proximal reactivation of intrinsic muscles in the fingers in cases of cubital
      paralysis in leprosy].

PMID- 1024730
TI  - [Ischemic necrosis of the anterior hypophysis (Sheehan's syndrome) in the black
      African (apropos of 5 personal cases)].

PMID- 1024731
TI  - [Rheumatoid polyarthritis in the black African (apropos of 43 cases observed at
      Dakar)].

PMID- 1024732
TI  - [Nervous system diseases during the course of diphtheria].

PMID- 1024733
TI  - [Juvenile forms of rheumatic heart disease in a tropical environment (apropos of
      582 cases in the Senegalese)].

PMID- 1024734
TI  - [Etiological and clinical aspects of oculo-palpebral burns in Saint Louis
      Senegal].

PMID- 1024735
TI  - [Spontaneous juvenile macular hemorrhage (apropos of 3 cases)].

PMID- 1024736
TI  - [Traumatic osteo-meningeal fistulas of the anterior level of the base of the
      skull and their complications (4 anatomo-clinical observations)].

PMID- 1024737
TI  - [Salmonella serotypes isolated in Togo].

PMID- 1024738
TI  - [Acute amicrobic and amebic abscess of the liver. Anatomic and physiopathological
      data concerning about 600 cases in Dakar (1960-1973)].

PMID- 1024739
TI  - [Practical value in neuro-ophthalmology of a new therapeutic method:
      embolization].

PMID- 1024740
TI  - [Limits of indications for cataract extraction in adults].

PMID- 1024741
TI  - [Electrooculography. Technic of recording and stimulation].

PMID- 1024742
TI  - [EOG. Presentation, trials and analysis].

PMID- 1024743
TI  - [Iridocycloretraction. Value in the treatment of irreducible hypertonia.
      Preliminary results].

PMID- 1024744
TI  - [Value of the combined trabeculectomy-vitrectomy operation in the treatment of
      secondary glaucoma by closure of the angle of the aphakia].

PMID- 1024745
TI  - [Severe bilateral cortico-dependent uveitis. Role of crystalline and retinal
      antigens].

PMID- 1024746
TI  - [Technical note on retinal pan-photocoagulation].

PMID- 1024747
TI  - [Technic of pan-retinal photocoagulation in diabetic retinopathy].

PMID- 1024748
TI  - [Notes on 0.03% phospholine iodide, with more than 4 years' experience].

PMID- 1024749
TI  - [How to detect and follow glaucoma in daily practice. Study of 40 personal
      cases].

PMID- 1024750
TI  - [Ophthalmologic complications in a series of 604 fractures of the cheekbone].

PMID- 1024751
TI  - [Diplopia and intra-orbital glass foreign body].

PMID- 1024752
TI  - [Idiopathic peripapillary choroidal neovascular membranes].

PMID- 1024753
TI  - [Juxta-papillary central serous choroiditis].

PMID- 1024754
TI  - [Thrombolytics in venous thromboses of the retina].

PMID- 1024755
TI  - [Study of a recent case of Urbach-Wiethe disease].

PMID- 1024756
TI  - [Cryotherapy in corneal herpes].

PMID- 1024757
TI  - [Acute keratoconus in Terrien's disease].

PMID- 1024758
TI  - Screening for breast cancer--a report of II 654 examinations.

PMID- 1024759
TI  - The selection of patients for breast cancer screening--is there a role for
      psychological testing?

PMID- 1024760
TI  - Delay in presentation of women with breast disease.

PMID- 1024761
TI  - Radical mastectomy: an analysis of 306 patients.

PMID- 1024762
TI  - Intermittent compression for lymphoedema of arm.

PMID- 1024763
TI  - Shoulder movement following mastectomy.

PMID- 1024764
TI  - Axillary recurrences after selective treatment of the axillary nodes in cancer of
      the breast.

PMID- 1024765
TI  - The management of locally advanced breast cancer by X-ray therapy.

PMID- 1024766
TI  - Metastatic carcinoma within the breast.

PMID- 1024767
TI  - Concomitant androgen therapy in the management of advanced breast cancer by
      cyclical combined chemotherapy.

PMID- 1024768
TI  - Chemical phlebitis after nitrogen mustard injection.

PMID- 1024769
TI  - Two-fold interindividual variation in plasma protein binding of phenytoin in
      patients with epilepsy.
AB  - Plasma protein binding of phenytoin (diphenylhydantoin) in 63 epileptic patients
      was investigated with an ultrafiltration technique at room temperature using 14C
      labelled phenytoin. A strong correlation was found between the total and the
      unbound drug concentration (r = 0.97, p less than 0.001). The unbound phenytoin
      fraction was 7.1 +/- 1.0% with a range of 4.9 to 10.2%. This variation is
      considerably less than that reported recently by different authors. Individual
      phenytoin binding was reproducible when the determination was repeated several
      weeks later. Salivary phenytoin concentrations in 33 epileptic patients were
      significantly correlated to the unbound (r = 0.83) and total concentrations (r =
      0.82) of phenytoin in plasma. This study confirms that the clinical practice of
      monitoring total phenytoin plasma concentrations is sufficient, since the unbound
      phenytoin fraction has only a 2-fold interindividual variation in epileptic
      patients, provided that they do not suffer from renal or hepatic disease.

PMID- 1024770
TI  - Predictors of drug use.

PMID- 1024771
TI  - Effects of an oral hygiene information film.

PMID- 1024772
TI  - Problems in the delivery of health care.

PMID- 1024773
TI  - The psychology of violence.

PMID- 1024775
TI  - Risks of everyday life.

PMID- 1024774
TI  - Equalities and inequalities: real and imagined.

PMID- 1024777
TI  - A solution to the problems of problems of providing refreshment at work.

PMID- 1024776
TI  - Speech problems among children in a national survey: associations with hearing,
      handedness and therapy.

PMID- 1024778
TI  - Aspects of modern meat technology.

PMID- 1024779
TI  - Community roots of delinquency.

PMID- 1024780
TI  - The Yo-Yo Syndrome and the community.

PMID- 1024781
TI  - Professionals in health service administration.

PMID- 1024783
TI  - The university environment in relation to mental health in Sudanese students.

PMID- 1024782
TI  - Aspects of hostel facilities for the mentally ill in Greater Manchester.

PMID- 1024784
TI  - Microwave ovens. 1. How well do they cook?

PMID- 1024785
TI  - Microwave ovens. 2. Is microwave leakage hazardous?

PMID- 1024786
TI  - How to buy a hearing aid. Part 1. What consumers should know.

PMID- 1024787
TI  - The replacement child--a developmental tragedy: some preliminary comments.
AB  - Some of the clinical and theoretical issues thought to be involved in the
      psychology of "replacement children" are discussed. A developmental framework is
      proposed within which to view such children. The replacement child is becoming an
      identifiable clinical syndrome, and a developmental framework is sorely needed to
      encourage more systematic research. A replacement child perceives his status
      differently on both a cognitive and emotional level within the context of each
      developmental phase, and the affective and associative links need to be reworked
      each time. We view the status of being a replacement child as a developmental
      interference insofar as demands are placed on the child's immature ego which he
      might not yet be equipped to cope with.

PMID- 1024788
TI  - The well-baby clinic.

PMID- 1024789
TI  - Neonatal prediction and outcome at 10/11 years.

PMID- 1024790
TI  - Applying the guidelines of Beyond the Best Interests of the Child.
AB  - Although the wisdom of the guidelines advocated in Beyond the Best Interests of
      the Child for making custody and visitation decisions is widely proclaimed, the
      realities of existing statutes and procedural systems preclude their simple
      application to present-day custody cases. It is the purpose of this paper to join
      the efforts of others in attempting to delineate how the theoretical policies and
      abstract strategies comprising these guidelines can be implemented under the
      constraints of present realities. This effort takes the form of three disguised
      cases to which is added the author's commentary on his interventions and
      recommendations.

PMID- 1024791
TI  - [Intraspinal epidermoid cyst].

PMID- 1024792
TI  - [Traumatic dysphagia due to anterior cervical osteophytosis].

PMID- 1024793
TI  - [Surgical approaches in Dupuytren's disease: critical analysis of current trends
      and recent results].

PMID- 1024794
TI  - [Treatment of pertrochanteric fractures in the old age using Ender's elastic pins
      (preliminary note)].

PMID- 1024795
TI  - [1st therapeutic experiences with cortisones in juvenile bone cysts].

PMID- 1024796
TI  - [Isolated paralysis of the accessory spinal nerve of spontaneous origin. Clinical
      and electromyographic study of 2 cases].

PMID- 1024797
TI  - [Electrodiagnostic considerations of rheumatoid arthritis].

PMID- 1024798
TI  - [Unusual study of a case of proximal non-traumatic dislocation of the radius].

PMID- 1024799
TI  - [Cat-scratch disease (presentation of a case)].

PMID- 1024800
TI  - [Jejuno-ileal bypass in the treatment of experimental obesity in the rat ( III :
      anatomo-histological studies].

PMID- 1024801
TI  - [Experimental interruptions of the circulation in the caudal vena cava in the
      dog. Hemodynamic and cavorgraphic changes].

PMID- 1024802
TI  - [ Report on a case of Wilson's disease : hemodynamic classification].

PMID- 1024803
TI  - [Homeostatic regulation of circulation in hypertension].

PMID- 1024804
TI  - [Cystometrographic and electromyographic values of the striated sphincter of the
      urethra in the evaluation of neurologic bladder due to spinal cord injuries].

PMID- 1024805
TI  - [Testicular biopsy in the diagnosis of male infertility].

PMID- 1024806
TI  - [Methods for the determination of venous tonus and clinical conditions of its
      use].

PMID- 1024807
TI  - The assessment of time-dependent changes in human performance.
AB  - This paper discribes a series of experiments to illustrate the use of various
      methods of time series analysis in the delineation of the effects of circadian
      and ultradian cycles on human performance. These experiments are concerned with
      measures of both human performance and physiology. They illustrate how the
      parameters of these time series analytic techniques can be used to postulate
      physiological mechanisms where time-dependent changes have been shown to be
      significant. The use of analytic techniques in both the time and frequency domain
      is illustrated.

PMID- 1024808
TI  - Circadian rhythmic aspects of human cardiovascular function: a review by
      chronobiologic statistical methods.

PMID- 1024810
TI  - Collagen biosynthesis in the aorta of spontaneously hypertensive rats.

PMID- 1024809
TI  - Localization of the lactate dehydrogenase (LDH) and of the acid phosphatase (AP)
      in liver cells of embryos and chickens irradiated with gamma rays.

PMID- 1024811
TI  - Cytogenetic investigation of cells from primary kidney culture of Testudo graeca.

PMID- 1024812
TI  - Effects of apomorphine, pimoside, theophylline, meta-tolylcarbamide and diazepam
      on the picrotoxin convulsive-seizure threshold.

PMID- 1024813
TI  - Histological classification of Kaposi's sarcoma. A basis for chemotherapy.

PMID- 1024814
TI  - Q fever in Kenya. Serological investigations in man and domestic animals.

PMID- 1024815
TI  - Urinary tract pathogens and antibiotic sensitivity patterns in Dar es Salaam.

PMID- 1024816
TI  - Surgical treatment of duodenal obstruction of vascular origin.

PMID- 1024817
TI  - Pelvic inflammatory disease associated with Enterobius vermicularis in the
      endometrium.

PMID- 1024818
TI  - Reduplication of distal femur. A case report.

PMID- 1024819
TI  - The relationship between systemic and ear-capsule blood pressure measurement.

PMID- 1024820
TI  - Structure-activity relationship in hypertensive steroids.

PMID- 1024821
TI  - Kala-azar in Ethiopia: sandflies (Diptera: Phlebotomidae) of Southwest Ethiopia.

PMID- 1024822
TI  - Kala-azar in Ethiopia: the phlebotomid sandflies of the Awash River Valley.

PMID- 1024823
TI  - Kala-azar in Ethiopia: survey and leishmanin skin test results in the middle and
      lower Awash River Valley.

PMID- 1024824
TI  - Why do Tc-99m chelates work for cholescintigraphy?
AB  - There are four structural requirements for substances that are excreted by the
      liver: 1. Their molecular weight is between 300 and 1,000. 2. They are organic
      anions. 3. They contain at least two ring systems in the molecule. 4. They are
      bound to serum albumin. All the Tc-99m chelates suggested for cholescintigraphy
      fulfill these requirements. For the first time a rational for their efficacy is
      provided.

PMID- 1024825
TI  - The correlation between liver scintigraphy and serum CEA levels in the detection
      of liver metastases from rectum carcinoma. A retrospective study.
AB  - Radiocolloid liver scintigraphy for the detection of liver metastases is widely
      used. Because of the known limitations of this technique we investigated the
      correlation between liver scintigraphy and serum CEA levels in patients with a
      confirmed diagnosis of primary rectum carcinoma. The serum CEA level is not
      suitable as a screening test for cancer, but it can be helpful as an extra
      parameter for the detection of liver metastases. The correlation between liver
      scintigraphy, the serum CEA level and the clinical findings has also been
      studied. A good correlation between liver scintigraphy and the serum CEA level
      was found. Serum CEA levels can be helpful in facilitating the evaluation of
      liver scintigraphy in patients with carcinoma of the rectum.

PMID- 1024826
TI  - Experimental examinations on the suitability of organoaminomethane-bis-phosphonic
      acids for bone-scintigraphy by means of Tc-99m in animals.
AB  - Phosphororganic compounds of the general formula R2N-CH (PO(OH)2)2 were examined
      for their Tc-99m-labelability and suitability for bone-scintigraphy. Compared to
      Tc-99-m-Sn-EHDP (Hydroxyethane-1,1-diphosphonic acid), four compounds showed a
      better concentration in the sceleton, while three compounds remained beneath
      comparative values.

PMID- 1024827
TI  - The use of 123I labelled oestradiol in detecting the human prostate using a gamma
      camera.
AB  - 123I labelled oestradiol was administered into patients with either benign
      hypertrophy or malignancy of the prostate, in order to detect the prostate. Using
      a gamma camera the results showed considerable radioactivity in the bladder
      prostate region. The exact anatomical position of the prostate was determined by
      emptying the bladder and introducing 123I labelled sodium iodide into the balloon
      of the catheter already inserted in the bladder. The results demonstrated that
      the detected radioactivity in this region was in the bladder rather than the
      prostate. This conclusion was later confirmed by the presence of high level of
      the radioactivity in the urine and the extremely low concentration of the
      radioactivity in the prostate after the removal of the gland.

PMID- 1024828
TI  - Bone imaging after total replacement arthroplasty of the hip joint. A follow-up
      with different radiopharmaceuticals.
AB  - Bone imaging was done in patients after total replacement arthroplasty of the hip
      joint every 3rd month using 99mTc-HEDP and 18F. Uptake ratios were estimated over
      cup/normal hip and femur prosthesis/normal thigh. Ratios decline rapidly and
      reach a stable level 6-9 months, postoperatively. Eight cases of late infection
      were predicted correctly 1-3 months before any radiologic evidence was present.
      In four cases there had been false-positive results with 99mTc-HEDP while 18F
      gave always correct information except in cases of soft tissue inflammation. Here
      both 99mTc-HEDP and 18F ratios were elevated. The early diagnosis of late
      complications after replacement arthroplasty seems to be possible. The clinical
      significance, however, is low: only one out of eight patients with manifest
      infection is still on conservative treatment. Bone imaging should be done to
      exclude late infection as a cause of pain after total replacement arthroplasty of
      the hip joint only.

PMID- 1024829
TI  - A note to "Radiochemical purity of various 99mTc-labelled bone-scanning agents".

PMID- 1024830
TI  - [Effect of sodium hydroxybutyrate, phenamine, transamine, l-DOPA on the physical
      work capacity of animals under multiple stress conditions].
AB  - Complete restoration of performance capacity in rats following a preliminary
      single exertion is shown to occur against the background of action produced both
      by transamine and its combination with sodium oxybutyrate. After a preliminary 4
      fold swimming transamine is effective only in combination with sodium
      oxybutyrate. With a combined action of sodium oxybutyrate and l-DOPA a prolonged
      increase of performance capacity of the animals under multiple loads is recorded.

PMID- 1024831
TI  - [Oxidative phosphorylation in different regions of the rat brain following
      morphine administration].
AB  - The influence exercised by morphine in a dose of 20 mg/kg, introduced
      intraperitoneally, and also in concentrations of 10(-3) and 10(-5) "in vitro" on
      the parameters of oxidative phosphorylation of the brain cortex and stem of rats
      was studied. Morphine, used in a concentration of 10(-3), is shown to speed up
      the substrates oxidation rate. During the first days of its administration the
      narcotic analgetic inhibited oxidation of mitochondia released from the brain
      stem, and, once habituation to the narcotic had developed, the inhibition ceased
      to be effective. In "in vivo" experiments and in vitro tests the effect of
      phosphorylation remained unchanged. The data obtained suggest that with
      developing habituation in regard to morphine the functions of the brain stem and
      cortex mitochondria do not undergo any substantial changes.

PMID- 1024832
TI  - [Effect of neurotropic drugs on pancreatic secretion and blood supply].

PMID- 1024833
TI  - [Sympathomimetic effect of serotonin and the influence of imipramine and
      fluoracizine on it].

PMID- 1024834
TI  - [Effect of pyrazidole on the concentration of endogenous noradrenaline in rat
      heart and brain tissues].

PMID- 1024835
TI  - [Hypotensive effect and toxicity of octadin and papaverine following their
      combined administration].
AB  - A study on the hypotensive action of combined injections of papaverine and
      octadine (guanethidine) was carried out in acute experiments on 90 anaesthetized
      cats. It was shown that with combined injections of octadine (in doses exceeding
      by 22% ED100) and of papaverine (in doses inferior by 22% to ED100) the
      hypotensive action was potentiated. A change of the said proportions led to a
      diminished hypotensive effect. It was also found that the most effective
      combinations of the 2 drugs was the one consisting of 0.5 mg/kg of papaverine and
      5 mg/kg of octadine (in a ratio of 1:10). By studying the toxicity of the 2 drugs
      and of their combinations on 350 albino mice it was ascertained that their
      toxicity diminished if the drugs were used together.

PMID- 1024836
TI  - [Effect of antipheins on indices of the activity of the pentosephosphate pathway
      for carbohydrate transformation].
AB  - Experiments set up on rabbits showed that with their intravenous administration
      in a dose of 10 mg/kg antiphein, aethimizol, allilnorantipheins and
      propylnorantiphein catalize the activity of the pentosophosphate mode of the
      carbohydrates transformation. The character of the action and the intensity of
      the effect depend on the features distinguishing the chemical structure of the
      substances, of particular importance here being changed conformation of the
      molecule.

PMID- 1024837
TI  - [Effect of diuretics on respiration and active Ca2+ transport in isolated rat
      renal mitochondria].

PMID- 1024838
TI  - [Diuretic activity of sulfo-derivatives of amides and oxalic acid hydrazides].

PMID- 1024839
TI  - [Experimental combined administration of cyclophosphane with serotonin, insulin
      and glucose].
AB  - Experiments on mice with sarcoma 37 evidenced that the use of cyclophosphan in
      combination with serotonin, insulin, insulin + glucose and serotonin + glucose
      enable it to obtain a more significant antineoplasic effect than this is possible
      by the treatment with cyclophan alone. A combined application of these agents
      produced a more profound inhibition of the glycogen-forming function and
      restitution of the glycogen cintent in the liver of the test animals occurred
      quicker than when cyclophosphan alone was used. In oncological practice it is
      recommended to use combinations of cyclophosphan with serotonin, insulin, insulin
      + glucose and serotonin + glucose.

PMID- 1024840
TI  - [Toxicologic features of mononitrophenols taking their isomeric forms into
      consideration].

PMID- 1024841
TI  - [Iodine metabolism in uranium poisoning according to whole-body radiometry and
      activation analysis].
AB  - Experiments on rats showed that in chronic uranium poisoning the value of the
      intrathyroid iodine pool changed and time-dependent radioiodine recirculation
      relationship between the thyroid and the organism was upset. The process of the
      thyroid adaptation is a complex one, viz. the hormonal capacity of the organism
      being kept up through an increase in the mass of the thyroid as well as by a
      higher rate of iodine exchange.

PMID- 1024842
TI  - [Changes in the phasic structure of the cardiac cycle in dogs with acute
      chlorophos poisoning].

PMID- 1024843
TI  - [Mechanism of renal excretion of ethambutol in tuberculosis patients].

PMID- 1024844
TI  - [Distribution of sodium hydroxybutyrate in the body following its intravenous
      administration].

PMID- 1024845
TI  - [Relationship between means of administration, concentration in the blood, organ
      distribution and excretion of prespidin-14C from the body].
AB  - Blood content, distribution among organs and tissues and passage from the
      organism of prospidine-C14 in rats, following its introduction per os and
      application to the skin in the form of an ointment, were studied. With these
      modes of introduction it is shown that prospidine and/or products of its
      biotransformation are capable of relatively quickly penerating through the wall
      of the gastro-intestinal tract and skin. However, specific radioactivity in the
      organs in such cases is scores of time lower than with intravenous
      administration. In case of the peroral introduction of the compound 72.3 per cent
      of the amount of the compound and/or of its metabolites administered are
      eliminated via the gastro-intestinal tract in two days.

PMID- 1024846
TI  - [Use of chromato-mass-spectrometry in pharmacokinetic research (review of the
      literature)].

PMID- 1024847
TI  - [Behavior of rosette-forming human lymphocytes in allogeneic cell mixtures].
AB  - Rosetting lymphocytes have been evaluated in allogeneic mixtures of human
      peripheral lymphoid cells. In these mixtures E-rosettes were inhibited as
      compared with that of individuals cells not sharing HLA antigens in common.
      Mixtures of lymphoid cells sharing HLA antigens in common (familiar combinations)
      were less or not inhibited. The inhibiting effect has been ascribed to shedding
      of HLA antigens in the allogeneic mixtures, interfering with the binding of sheep
      erythrocytes to lymphoid cells. These results confirm the existence of a very
      closely association between antigen receptor and HLA products on the cell surface
      of T-lymphocytes.

PMID- 1024848
TI  - [Etiopathogenic considerations on a case of talipes equinovarus due to parasitic
      muscular disease].

PMID- 1024849
TI  - Limulus test, parenteral drugs and biological products: an approach.
AB  - The Authors report the results concerning the control of presence of bacterial
      endotoxins in parenteral drugs, blood products and immunological materials, by
      means of Limulus amebocyte lysate test. All the data suggest that Limulus assay
      is a simple, rapid, specific and sensitive test for endotoxin detection, mostly
      when it is correctly performed.

PMID- 1024850
TI  - [A new colorimetric test in oncologic diagnosis: experiences and evaluation
      criteria].
AB  - The authors have examined a new colorimetric test, set up by Nixon in 1973 and
      appropriately modified by them. They have found out 80,14% positive reactions in
      146 cases of neoplasms and 82,54% negative reactions in 126 patients suffering
      from tubeycular and different diseases; lastly 95% negative reactions in
      apparently healthy individuals. According to the authors' opinion, this test
      seems to be useful in the diagnosis of neoplasms, when joined, of course, with
      other diagnostic means now in use.

PMID- 1024851
TI  - In vivo and in vitro cell-mediated immune reactions to auto-chthonous tumor
      extracts in patients with gastric cancer.
AB  - Sixty patients with advanced gastric cancer were subjected to the macrophage
      electrophoretic mobility test and delayed hypersensitivity skin test to tumor and
      normal tissue (gastric mucosa) extracts. Tumor extract induced significant
      inhibition of macrophage mobility in 51% and positive skin reaction in 32% of
      examined cases. Close correlation was observed between macrophage inhibition and
      diameter of skin reaction to tumor extract. Incidence of positive reaction in
      both tests to normal tissue extract was 55% and 12%, respectively. Significant
      inhibition of macrophage to tumor extract was also observed in breast cancer, but
      not in superficial gastric cancer and healthy persons. Normal tissue extract did
      not induce significant inhibition of macrophage in gastric ulcer. These results
      suggest that macrophage electrophoretic mobility test indicates a certain aspect
      of tumor-associated (but not tumor-specific) immunity in cancer patients.
      Macrophage inhibition appeared to be related with macroscopic tumor types rather
      than to clinical stages. Positive skin reaction to tumor extract was observed in
      Stages II, III, and IV of gastric cancer.

PMID- 1024852
TI  - Effect of DL-alpha-hydrazino-delta-aminovaleric acid, an inhibitor of ornithine
      decarboxylase, on polyamine metabolism and growth of mouse sarcoma-180.
AB  - DL-alpha-Hydrazino-delta-aminovaleric acid (DL-HAVA) is a potent and fairly
      specific inhibitor of ornithine decarboxylase (EC 4.1.1.17). Its effect on
      polyamine metabolism and cell proliferation was investigated in sarcoma-180,
      inoculated into the axillary region of mice. In the tumor tissues, the activities
      of ornithine and S-adenosyl-L-methionine decarboxylases and the putrescine level
      were much higher in the early stage of growth than those in normal mouse liver.
      Administration of DL-HAVA greatly depressed the putrescine level and putrescine
      formation from L-ornithine. It also suppressed DNA synthesis and increase in
      weight of the tumor tissue. However, it had little effect on RNA synthesis or the
      tissue concentration of spermidine and spermine. The inhibition of DNA synthesis
      and subsequent tumor development by DL-HAVA was effectively prevented by
      putrescine, but not by cadaverine or 1,7-diaminoheptane. From these results it is
      concluded that the suppression of DNA synthesis and neoplastic growth by DL-HAVA
      is due to decrease in the putrescine level by inhibition of ornithine
      decarboxylase.

PMID- 1024853
TI  - Isolation of soluble immunosuppressive substance(s) from Ehrlich ascites tumor
      cell nuclei.
AB  - A potent immunosuppressive principle was isolated in a soluble form from the
      nuclei of Ehrlich ascites tumor cells. DNA-free preparation, obtained from the
      purified nuclei by homogenizing in 2M NaCl-5M urea solution and removing the
      dissociated DNA with LaCl3-precipitation, revealed strong activity to suppress
      the development of helper thymus-derived lymphocyte activity in mice. Moreover,
      almost all of the immunosuppressive activity originally found in the nuclear
      residue fraction after extraction with sodium citrate solution was recovered in
      0.25 N HCl extract which mainly contains proteins. The nuclear components of
      tumor cells were also detected in the body fluid of tumor-bearing animals, as
      examined by the reactivity with a rabbit antiserum specific for some nuclear
      component of Ehrlich tumor cells. These results suggest that the
      immunosuppressive principle in the nuclei of Ehrlich tumor cells is a histone
      like substance, and liberated into the body fluid from tumor cell nuclei in the
      tumor-bearing state.

PMID- 1024854
TI  - Cancer induction in subcutaneously implanted bronchial autograft of a dog by 3
      methylcholanthrene.
AB  - An experimental cancer induction in subcutaneously autoimplanted bronchial grafts
      in dogs was studied. After successful bronchial autografting, 3
      methylcholanthrene or 3,4-benzo[a]pyrene suspended in sterile saline solution
      containing 1% carboxymethylcellulose was injected into the lumen. Twenty-eight
      weeks after this treatment, an invasive squamous cell carcinoma with
      concomitantly existing atypical squamous metaplasia was found in one dog by
      histological examination. Squamous cell metaplasia was also observed in two other
      dogs at 24th experimental week. Cytological examination revealed the findings
      corresponding to these epithelial changes. Remaining 15 dogs are still living and
      under observation.

PMID- 1024855
TI  - Correlation between phytohemagglutinin skin test and delayed cutaneous
      hypersensitivity to dinitrochlorobenzene in cancer patients.

PMID- 1024856
TI  - Antitumor activity of asterriquinone, a metabolic product from Aspergillus
      terreus.

PMID- 1024857
TI  - Assessment of parameters of physical growth of the newborn in relation to
      maternal supplementation with iron alone or with some biological additives.
AB  - Intrauterine growth charts were used for the assessment of physical growth of
      newborn infants in relation to maternal supplementation. Iron alone or with other
      additives (Copper, folic acid, ascorbic acid) were given during different
      trimesters of pregnancy. The study revealed that iron supplementation with or
      without other additives has an effective role in improving the haematological
      pattern in the neonates who also achieved better physical growth particularly
      with early supplementation with iron and ascorbic acid. Therefore, such
      supplementation is recommended.

PMID- 1024858
TI  - Diagnosis aids in hepatomegaly. An approach to differential diagnosis.

PMID- 1024859
TI  - [Cytochemistry of megakaryocytes. II. Acid phosphatase. 3. Basic method for
      cytochemical study].

PMID- 1024860
TI  - [Microlaryngoscopy at the clinic for oto-, rhino-, laryngology in Skopje].

PMID- 1024861
TI  - [Nystagmogram of the posterior labyrinth after stapdectomy].

PMID- 1024862
TI  - [Unusual picture of the liver scintigram].

PMID- 1024863
TI  - [Partogram in the active management of labor].

PMID- 1024864
TI  - The correlation of the haemostatic disorder, clinical-biochemical state and
      treatment in patients with hepatic coma complicated acute viral hepatitis.

PMID- 1024865
TI  - [Comparative studies on the value of domestic barium sulfate and micropowdered
      preparations].

PMID- 1024866
TI  - [Use of radioisotope in the diagnosis of brain abscess and rhino-otogenic liquor
      fistula].

PMID- 1024867
TI  - [Hemostatic disorders in infectious and inflammatory diseases].

PMID- 1024868
TI  - [Glucose-6-dehydrogenase deficiency in the etiology of neonatal
      hyperbilirubinemia].

PMID- 1024869
TI  - [Clinico-radiological exploration using the contrast medium iodamide].

PMID- 1024870
TI  - [Surgical treatment of essential epistaxis].

PMID- 1024871
TI  - [Advantages and disadvantages of composite resins].

PMID- 1024872
TI  - [Dynamometric data of children in the pubertal age].

PMID- 1024873
TI  - [Evaluation of x-ray methods in the diagnosis of female genital tumors].

PMID- 1024874
TI  - [Scintigraphic findings on the liver in chronic viral hepatitis].

PMID- 1024875
TI  - [Our experiences with fiber bronchoscopy].

PMID- 1024876
TI  - [Malignant tumors of the nasopharynx].

PMID- 1024877
TI  - [Acute pulmonary embolism as a diagnostic and therapeutic problem].

PMID- 1024878
TI  - [Hemangioma of the paranasal sinuses in the material of the ORL clinic in Skopje
      during 1970-1975].

PMID- 1024879
TI  - [Carbon monoxide and safety in crane operators in black metallurgy].

PMID- 1024880
TI  - [Hearing disorders and deafness in the material of the ORL clinic in Skopje].

PMID- 1024881
TI  - [Pancreatic endopeptidase in the treatment of the Ramsay Hunt syndrome].

PMID- 1024882
TI  - [Acute spontaneous compressive intracranial hemorrhage as a result of ruptured
      aneurysm due to arteriovenous malformation].

PMID- 1024883
TI  - [Neurosurgical treatment of expansive processes in the posterior cranial fossa].

PMID- 1024884
TI  - [Electroencephalographic changes of brain tumors in children].

PMID- 1024885
TI  - [Evaluation of the most frequent symptoms of expansive intracranial processes in
      childhood].

PMID- 1024886
TI  - [Prolonged neonatal jaundice as an early manifestation of congenital
      hypothyroidism].

PMID- 1024887
TI  - [Occupational risk in the production of polyvinyl chloride].

PMID- 1024888
TI  - [Sagittal occlusion anomalies in trisomy 21].

PMID- 1024889
TI  - [Practical approach to the treatment of cirrhotic ascites].

PMID- 1024890
TI  - [Morphological characteristics of the palate in trisomy 21].

PMID- 1024891
TI  - [Incidence of genital tumors in childhood and adolescence].

PMID- 1024892
TI  - [Use of ventricular auriculostomy and ventricular peritoneostomy following the
      Pudenz-Heyer and Spitz-Holter method in the surgical therapy of internal
      hydrocephalus].

PMID- 1024893
TI  - [Gunshot wounds in the heat in peace time].

PMID- 1024894
TI  - [Use of the Ray-Camille osteosynthesis in unstable fractures].

PMID- 1024895
TI  - [TSH value in children with normal thyroid function and primary hypothyroidism].

PMID- 1024896
TI  - [Therapeutic procedures in chronic hepatitis and liver cirrhosis].

PMID- 1024897
TI  - Diagnostic aspects of the chronic evolution of the alcoholic liver disease.

PMID- 1024898
TI  - [Dysplasia fibrosa].

PMID- 1024899
TI  - [Reconstructive surgery in the treatment of postoperative pharyngeal fistula.
      Material of the ORL clinic in Skopje].

PMID- 1024900
TI  - [Pseudotumorous form of laryngeal tuberculosis as non-diagnosed cases of
      evolutive pulmonary tuberculosis].

PMID- 1024901
TI  - [Selective deficiency of immunoglobulin A].

PMID- 1024902
TI  - [Neurosurgical treatment of basal endocranial tumors localized in the anterior or
      middle cranial fossa].

PMID- 1024903
TI  - [Prognostic significance of postural and tonic reflex activities in cerebral
      palsy].

PMID- 1024904
TI  - [Hemodialysis and serum hepatitis].

PMID- 1024905
TI  - [Induced labor in prolonged pregnancy].

PMID- 1024906
TI  - [Endoscopic study of the bladder in carcinoma of the cervix].

PMID- 1024907
TI  - [Effect of tetracycline therapy on teeth].

PMID- 1024908
TI  - [Use of massive radiophotography in the early diagnosis of arterial
      hypertension].

PMID- 1024909
TI  - The prothrombin activation in stored blood.

PMID- 1024910
TI  - [Renal anemia in relation to the basic pathological status and renal function].

PMID- 1024911
TI  - State of comma as consequence from a traumatic subdural hygroma. Auer methode.
      Personal experience.

PMID- 1024912
TI  - [Dialysis--ascites syndrome].

PMID- 1024913
TI  - [Megaesophagus in a child].

PMID- 1024914
TI  - [Size of the kidney as an element of clinical evaluation].

PMID- 1024915
TI  - [Apropos of 2 deliveries at term with an intrauterine device in situ--1 malformed
      infant].

PMID- 1024916
TI  - [Diabetes and pregnancy].

PMID- 1024917
TI  - [Ileus and pregnancy].

PMID- 1024918
TI  - [Surgical treatment of disk hernia in the lumbosacral region].

PMID- 1024919
TI  - [Congenital adrenal hyperplasia].

PMID- 1024920
TI  - [Our experiences in the treatment of herpetic keratitis using solcoseryl].

PMID- 1024921
TI  - [Diagnosis and surgical treatment of localized cyanotic pulmonary arteriovenous
      fistula].

PMID- 1024922
TI  - [Siamese twins].

PMID- 1024923
TI  - [A case of hydatidiform mole as a toxic syndrome in a very young woman treated
      successfully using the vacuum extraction method].

PMID- 1024924
TI  - [Radiation nephritis. Clinical report of 2 cases].

PMID- 1024925
TI  - Rhabdomyosarcoma of the larynx.

PMID- 1024926
TI  - [2 cases of severe hemorrhagic shock and heart arrest].

PMID- 1024927
TI  - [Use of garamycin in gynecology and obstetrics].

PMID- 1024928
TI  - [Histophysiological changes in the intermediate part of the hypophysis exposed to
      the continuous influence of light].

PMID- 1024929
TI  - [Seasonal-rhythm in the C cells of the thyroid gland in bulbectomized rats].

PMID- 1024930
TI  - [Histophysiological properties of parafollicular cells in the thyroid gland of
      the bat (Myotis oxygnatus)].

PMID- 1024931
TI  - [Cytochemistry and megakaryocytes. II. Acid phosphatase. 1. Determination on
      enzymes].

PMID- 1024932
TI  - [Cytochemistry of megakaryocytes. II. Acid phosphatase 2. Choice of basic
      technics for cytochemical study].

PMID- 1024933
TI  - Ferrokinetic circadian rhythm in normal subjects.

PMID- 1024934
TI  - The effect of erythropoietin on ribonucleic acid synthesis in the rabbit bone
      marrow.

PMID- 1024935
TI  - Pathophysiological classification of anaemias and polycythaemias (polyglobulias).

PMID- 1024936
TI  - Thrombocytopoietic serum activity in thrombocytopenia induced by antithrombocytic
      serum in mice.

PMID- 1024937
TI  - [Coronary cineangiography in women].

PMID- 1024938
TI  - [Evaluation of submaximal oxygen consumption as a parameter of cardiovascular
      fitness].

PMID- 1024939
TI  - [Nasopharyngeal cancer in Israel].

PMID- 1024940
TI  - [A method for improvement of human sperm motility in vitro].

PMID- 1024941
TI  - [The frequency of streptococci in nonpyogenic cutaneous lesions].

PMID- 1024942
TI  - [Progressive degeneration of the lower motor neuron as a late complication of
      poliomyelitis].

PMID- 1024943
TI  - [Macrodactily of the thumb and its treatment].

PMID- 1024946
TI  - [Skin biopsy].

PMID- 1024945
TI  - [The campomelic syndrome].

PMID- 1024949
TI  - [The intestinal vasoactive peptide and the watery diarrhea syndrome].

PMID- 1024950
TI  - [Intermittent mandatory ventilation--I.M.V].

PMID- 1024951
TI  - [Association of carcinoma of the colon with fats and steroid compounds in the
      diet].

PMID- 1024952
TI  - [The prognosis in juvenile asthma].

PMID- 1024953
TI  - [Clinical pharmacology of theophyllin in bronchial asthma].

PMID- 1024954
TI  - Certain aspects of histogenesis of the B (Ashkenazy) cells in the human thyroid
      gland.
AB  - Certain differences are found in the localization of the peroxidase in
      subcellular structures of the neoplastic A- and B-cells of the human thyroid. The
      differences may result from functional pecularities and developmental diversities
      of these cells.

PMID- 1024955
TI  - Attempts at inhibition of autooxidation of catecholamines in vitro.
AB  - The authors attempted to inhibit autooxidation of catecholamines in vitro by
      means of sulphur-containing amino-acids, monosaccharides, and aminobutyric acids.
      The SH group-containing amino-acids were found to suppress autooxidation of
      catecholamines passing from a chloroform-methanol solution (2:1) to water or
      buffer solutions. A similar though less pronounced property was manifested by
      cysteic acid. Likewise glucose, fructose and galactose blocked the reaction.
      Among aminobutyric acids only gamma-aminobutyric acid inhibited autooxidation of
      amines. However, despite positive results obtained, these experiments cannot be
      utilized in studies on reduction of Nitro-BT, as no reduction of Nitro-BT occured
      in the solutions in which catecholamine autooxidation was brought to a stop.

PMID- 1024956
TI  - Two strange health tribes: the Gnisrun and Enicidem in the United States.

PMID- 1024957
TI  - Social processes and psychiatric symptom pattern change: Wallace revisited.

PMID- 1024958
TI  - On the interaction of sugar phosphates & cations with UDPglucose 4-epimerase from
      Saccharomyces fragilis.

PMID- 1024959
TI  - Studies on human trypsin & chymotrypsins.

PMID- 1024960
TI  - Natural plant enzyme inhibitors: Part III-purification of protease inhibitors
      from Lathyrus sativus seeds.

PMID- 1024961
TI  - Acid phosphatase activity in a fresh-water air breathing fish Heteropneustes
      fossilis & the effect of certain organic pesticides on it.

PMID- 1024962
TI  - Use of alpha-chymotrypsin in the hydrolysis of esters of p-nitro, p-nitroso, p
      amino dihydrocinnamoyl groups used in oligonucleotide synthesis.

PMID- 1024963
TI  - Electronic structure of adenine & possibility of proton tunneling in the A-T base
      pair of DNA.

PMID- 1024964
TI  - Studies on acylation of lysolecithin in chicken intestine.

PMID- 1024965
TI  - Positional distribution of fatty acids in phosphatidylethanolamine of Vibrio
      cholerae 569 B (Inaba) at different growth conditions.

PMID- 1024966
TI  - Studies on lipopolysaccharide and prostaglandin E1- induced hyperthermia on
      rabbits: Part I--biochemical changes in liver and muscle.

PMID- 1024967
TI  - Effect of acetyl salicylic acid & prostaglandins on renal & hepatic
      gluconeogenesis in male albino rats.

PMID- 1024968
TI  - Dietary protein & metabolism of glycoproteins.

PMID- 1024969
TI  - Pathway for the biosynthesis of delta-aminolevulinic acid in greening potatoes.

PMID- 1024970
TI  - Biosynthesis of oligosaccharides and fructans in Agave vera cruz: Part II-
      biosynthesis of oligosaccharides.

PMID- 1024971
TI  - Biosynthesis of oligosaccharides and fructans in Agave vera cruz: Part III
      biosynthesis of fructans.

PMID- 1024972
TI  - Effect of acetyl salicylic acid & prostaglandins on the rate of anaerobic
      glycolysis in liver & kidney of rats.

PMID- 1024973
TI  - Comparative studies on the enzymes of different strains of Vibrio cholerae &
      Vibrio parahaemolyticus.

PMID- 1024974
TI  - Effects of drugs on muscle : Part I--Non-narcotic analgesics.

PMID- 1024975
TI  - Acetylcholinesterase in the heart of scorpion Heterometrus fulvipes (C. L.
      Koch.).

PMID- 1024976
TI  - Oxygen uptake capacity in relation to respiratory surface area of an air
      breathing siluroid fish Saccobranchus (=Heteropneustes) fossilis (Bloch).

PMID- 1024977
TI  - Effect of dietary protein & inositol on sperm metabolism & fructose content of
      male accessory sex organs of rat.

PMID- 1024978
TI  - In vitro calculogenesis : an improved experimental model.

PMID- 1024979
TI  - Effect of clomid on thyroids, diencephalic ependyma & subependymal cells in
      ovariectomized pigeon Columba livia (Gmelin).

PMID- 1024980
TI  - Mechanism of intestinal absorption of tetracyclines.

PMID- 1024981
TI  - Effect of tetramisole upon certain biochemical constituents of Ascaridia galli.

PMID- 1024982
TI  - Phenotype of mammalian spermatozoa in relation to genetic content.

PMID- 1024983
TI  - Effects of a single injection of alpha-chlorohydrin/cadmium chloride into vas
      deferens on testicular function of dog.

PMID- 1024984
TI  - Histochemical observations on gonadotrophic regulation of cholesterol-positive
      lipid droplets in ovaries of hypophysectomized rats.

PMID- 1024985
TI  - Effects of chemical occlusion of vas deferens on the reproductive organs in
      gerbil Meriones hurrianae Jerdon.

PMID- 1024986
TI  - Plasma testosterone levels in intact & hemicastrated rabbits.

PMID- 1024987
TI  - Effect of 3-(3,4-dihydro-6-methoxy-2-naphthyl)2,2-dimethyl pentanoic acid--an
      antifertility agent--on in vitro uptake of estradiol 17beta-6, 7(3)-H in rat
      uterus.

PMID- 1024988
TI  - Efect of selected metal ions on glutamate dehydrogenase activity in cell-free
      extracts of goat liver.

PMID- 1024989
TI  - Screening of Indian plants for antifertility activity.

PMID- 1024990
TI  - Action of haloperidol on mitoses in Allium cepa.

PMID- 1024991
TI  - Effect of normal & defective vasectomy on the biochemistry of testis & accessory
      genital organs of dogs.

PMID- 1024992
TI  - Steroid synthesizing cellular sites in the ovaries of Calotes versicolor (Daud.),
      Hemidactylus flaviviridis (Ruppel) & Chamaeleon calcaratus (Boulenger):
      histochemical study.

PMID- 1024993
TI  - Oxidation of ephedrine in rat brain.

PMID- 1024994
TI  - Association of a pool of free amino acids with cardiac myofibrils.

PMID- 1024995
TI  - Effect of high altitude stress on lung compliance in rats.

PMID- 1024996
TI  - Cardiovascular effects & mode of action of 1,2 dihydroxyphenyl (4-pyridinium
      bromide).

PMID- 1024997
TI  - Presence of functional renal thyroid in the teleost Cirrhinus mrigala (Ham).

PMID- 1024998
TI  - Effect of exogenous testosterone propionate & progesterone on testicular ascorbic
      acid & cholesterol in relation to spermatogenesis.

PMID- 1024999
TI  - Testosterone & lipid metabolism in rabbits.

PMID- 1025000
TI  - Hyperthermia & acetylcholine content of dog heart.

PMID- 1025001
TI  - Intestinal absorption of different penicillins.

PMID- 1025002
TI  - Effect of different levels of nutrition on heat & methane production in non
      lactating zebu cows.

PMID- 1025003
TI  - Antifungal flavonoid from Alpinia officinarum Hance.

PMID- 1025004
TI  - A-7, a new tetraene antifungal antibiotic.

PMID- 1025005
TI  - Accidents and poisoning in children with reference to data from India and Canada.

PMID- 1025006
TI  - An analysis of 42 cases of intussusception.

PMID- 1025007
TI  - Glucose-6-phosphate dehydrogenase, reduced glutathione and heinz bodies in
      congenital haemolytic anaemia.

PMID- 1025008
TI  - Anhydrotic ectodermal dysplasia.

PMID- 1025009
TI  - Malposition of the midbrain and hindbrain without any clinical manifestations.

PMID- 1025010
TI  - Assessment of rheumatic activity by laboratory methods.

PMID- 1025011
TI  - Birth injuries in the newborn.

PMID- 1025012
TI  - Bronchiectasis in childhood.

PMID- 1025013
TI  - Foetal haemoglobin concentration in cord blood in relation to gestational age.

PMID- 1025014
TI  - Progeria with osteoarthritis in a four-year-old girl. A case report.

PMID- 1025015
TI  - Infant feeding and child rearing methods in Pondicherry, South India.

PMID- 1025016
TI  - Infant feeding practices in urban and rural areas in Madhya Pradesh.

PMID- 1025017
TI  - Tetanus in childhood.

PMID- 1025018
TI  - Effect of maternal toxaemia on total haemoglobin, foetal haemoglobin and
      nucleated red blood cells in cord blood.

PMID- 1025019
TI  - Influence of severity of diarrhoea on carbohydrate intolerance in well nourished
      infants.

PMID- 1025020
TI  - Cord blood serum proteins and their fractions as an index of neonatal maturity.

PMID- 1025021
TI  - Placental protein free alpha amino nitrogen and nucleic acids in maternal under
      nutrition.

PMID- 1025022
TI  - Quick nutritional screening by midarm circumference or a bangle.

PMID- 1025023
TI  - Anthropometric profile of the pre-school children of Punjab.

PMID- 1025024
TI  - Immunization status in a rural community--a study of 360 families.

PMID- 1025025
TI  - Some aspects of family planning in a defined urban population of Jammu (Kashmir).

PMID- 1025026
TI  - Congenital cystic adenomatoid malformation of the lung--case report.

PMID- 1025027
TI  - Ganser's syndrome: a rare psychiatric disorder.

PMID- 1025028
TI  - Clinico--pathological conference.

PMID- 1025029
TI  - Mesenteric lymphatic cyst.

PMID- 1025030
TI  - Detoxification of long-term methadone patients: problems and prospects.
AB  - Various aspects of the detoxification of rehabilitated methadone patients are
      considered in the light of experience at the Albert Einstein College of Medicine
      Bronx Psychiatric Center MMTP and the reports of others in the field. Patients
      studied met certain eligibility requirements which were thought to enhance the
      probability of successful detoxification. A total of 228 (10.4%) of 2,814
      patients were included in the project. Sixty-three patients have completed
      detoxification. A follow-up on these patients indicates that 22.2% claim
      abstinence from all drugs and are reporting to the clinic, 47.6% claim abstinence
      but have not reported to the clinic, 14.3% returned to methadone maintenance, and
      15.9% are lost to contact. This and other studies emphasize the importance of
      adequate counseling during detoxification.

PMID- 1025031
TI  - Criminal behavior patterns of female addicts: a comparison of findings in two
      cities.
AB  - A great deal of the literature on addiction is devoted to analyses of the
      relation between drugs of addiction and crime among males. The few studies which
      have undertaken to describe the relationship between crime and addiction in
      females have generally concluded that addicted females either become prostitutes
      or they commit crimes against property. This study of addicted female arrestees
      in Denver (N = 153) and Philadelphia (N = 227) concluded that the hypothesized
      either-or pattern of addicted female criminal behavior is overly simplistic.
      Rather, four criminal behavior patterns of female arrestees are found: (1)
      prostitutes without a history of serious crimes, (2) females with a history of 
      serious crimes who are not prostitutes, (3) females who are both prostitutes and
      commit serious crimes, and (4) females who are not prostitutes and who commit
      only minor offenses. The utility of the four-pattern typology is borne out by
      analyses which indicate that these patterns are typical of different groups of
      female addicts and are not stages in a unitary socialization pattern involving
      drugs, prostitution, and crime.

PMID- 1025032
TI  - Alpha conditioning as an adjunct treatment for drug dependence: part I.
AB  - The effects of alpha conditioning on the habits of four methadone maintained
      patients were assessed. All four learned some control over alpha activity in the
      5-week, 10-session training period. The most striking results, however, related
      to the subjects' substitution of self-initiated mental states associated with
      alpha for previously used drug-seeking or self-medicating methods of coping with
      everday problem situations. All four subject reported a decrease in illicit drug
      usage and an increased feeling of self-control. Verification of improvement in
      adjustment and drug abuse was shown by counseling reports and narcotic screens
      from the maintenance program.

PMID- 1025033
TI  - The use of l-alpha-acetylmethadol in treatment of heroin addiction: an open
      study.

PMID- 1025034
TI  - Characteristics of new admissions to a narcotics treatment program: 1970-1974.
AB  - Study was made of the demographic and drug-using characteristics of new
      admissions to a narcotic treatment program over the course of a 4-year period.
      Samples were drawn of 100 new admissions during the month of April in each year
      from 1970 to 1974. Results indicate that the treatment program under study came
      to be working with caseloads increasingly court referred, increasingly
      nonminority, and less frequently prepared to volunteer for methadone maintenance
      treatment. New admissions claimed to have delayed entrance into treatment based
      on the geographic inaccessibility of treatment programs or the fact that they did
      not consider themselves ready for treatment. Implications for the provision of
      treatment to heroin users are discussed.

PMID- 1025035
TI  - In vitro cultivation of Schistosoma japonicum.

PMID- 1025036
TI  - Urban dogs in Houston, Texas--parasitic infection and environmental health
      impact.

PMID- 1025037
TI  - Zoonoses in Cyprus. Past and present including a comment on the public health.

PMID- 1025038
TI  - Studies on the zoonotic cycle of Taenia saginata taeniasis and cysticercosis in
      the Philippines.

PMID- 1025039
TI  - A comparison of buoyant density and polypeptides of Drosophila P, C and A
      viruses.
AB  - On the basis of their buoyant densities in CsCl and their capsid polypeptides,
      three viruses isolated from Drosophila spp. which were originally described as
      serotypes, are now classified as distinct viruses. The biochemical properties of
      each virus suggest that it has several key features in common with the mammalian
      picornaviruses.

PMID- 1025040
TI  - Two and two make five---multifactoriogenesis in mental illness in Ireland.

PMID- 1025041
TI  - Antibiotic residues in human foods derived from animals.

PMID- 1025042
TI  - Radical radiotherapy in the management of prostatic carcinoma. A review of
      current literature.

PMID- 1025043
TI  - Paraquat poisoning.---Report of a survivor.

PMID- 1025044
TI  - Neurophysiology---part VI.

PMID- 1025045
TI  - The professional man: education and assessment.

PMID- 1025046
TI  - Dissolution properties of digoxin tablets marketed in the Republic of Ireland.

PMID- 1025047
TI  - Turmoral calcinosis-an obscure disease. A report of four cases.

PMID- 1025048
TI  - MacLeod's syndrome.

PMID- 1025049
TI  - Leptospirosis and acalculous cholecystitis.

PMID- 1025050
TI  - Toward a utility theory foundation for health status index models.
AB  - The axioms of utility theory are restated in terms of health outcomes, and some
      additional assumptions, consistent with the assumptions implicit in health status
      index models, are adduced to develop a consistent theory of the utility of health
      states. On the basis of the axioms and specific assumptions, techniques for
      measuring the health utility functions of individuals are described, and it is
      shown how these axioms and assumptions may be used to determine the utility to
      the individual of health programs that will affect him in various ways.

PMID- 1025051
TI  - Neglected aspects of the quality of life.
AB  - Health status indexes have focused on physical function such as the activities of
      daily living, perhaps because the National Health Survey provides data of this
      sort or because it is the object of rehabilitation programs. In an attempt to
      elicit values concerning loss of function, 150 health workers were asked to
      assign weights from zero to 10 for 50 abilities or functions. Serious
      methodological problems were encountered in finding terms describing functional
      loss that were simple and meaningful to a wide range of workers. In addition, an
      open-ended request was made to identify other functions not included in the list.
      The largest average values were assigned to ability to use one's mental
      abilities, to see, to think clearly, to love and be loved in return, to make
      decisions for oneself, to live at home, to walk, to maintain contact with family
      and friends, and to talk. Some of the functional loss implied in these responses
      may not be amenable to cure or rehabilitation but may be preventable and thus
      needs to be included in outcome measures.

PMID- 1025052
TI  - Development and application of an index of social function.
AB  - Brief indexes of social function were constructed in a project to develop a
      health index questionnaire designed to measure the social, emotional, and
      physical function of free-living populations. The social function items have been
      found to be generally applicable, capable of application by lay interviewers, and
      acceptable to interviewees. Initial evaluations to form composite scores for
      social function items have demonstrated their validity against concurrent
      assessments of a health professional. These social function indexes have been
      successfully applied in two randomized trials of innovative primary care
      services. The criteria for inclusion of items in the social function index
      questionnaire, the generation of the instrument, and the evaluation of
      questionnaire responses for their validity are summarized here.

PMID- 1025053
TI  - Making annual indexes of health.
AB  - A discrete-state, continuous-time Markov model of health states and state
      transition probabilities is outlined as the basis of a health index that would
      reflect the annual health distribution and expected health changes of a
      population. The final index is an additive one, summing expected durations of the
      various health states over the entire population sample. The weights attached to
      the expected durations are derived from the instantaneous incidence rates, or
      intensity functions, that define the transition  probabilities. A general
      procedure for collecting data during overlapping 6-week periods from numerous
      population subsamples is described.

PMID- 1025054
TI  - Health status: patient and physician judgments.
AB  - Patients at a rehabilitation center in Derbyshire, England, were asked to assess
      their own functional abilities at admission and again at discharge, using an 82
      item questionnaire concerning 12 areas of daily living. Questionnaire responses
      were correlated with results of physical examinations, assessments by center
      personnel, and assessments of capacity for specific body movements. The highest
      correlations were observed in areas that related most directly to physical
      movements and to dressing and toileting. The results suggest that self-assessment
      of health status using this questionnaire may provide a viable alternative to
      judgments made by trained assessors.

PMID- 1025055
TI  - Validation of an interval scaling: the sickness impact profile.
AB  - The Sickness Impact Profile (SIP) is a measure of sickness-related behavioral
      dysfunction consisting of 189 items in 14 topic categories. To increase its
      discrimination, precision, and sensitivity in accounting for variance, the
      decision was made to scale the instrument. A two-step direct scaling procedure
      was used in order to avoid the monumental scaling tasks required by indirect
      procedures that guarantee equal-interval results; but because an equal-interval
      scale was needed, it was necessary to validate the scale values obtained and
      investigated the equal-intervval properties of the obtained scale. A three-stage
      validation process is described, consisting of an initial scaling by a group of
      25 health professionals and students in 1973, a second scaling by 108 members of
      a prepaid group health plan in 1975, and an investigation of the metric
      properties of the resulting scale values. In addition, the concept of dysfunction
      underlying the SIP was validated. SIP scores from a field trial were compared
      with mean ratings of severity of dysfunction represented by the combinations of
      checked items from which the scores were derived.

PMID- 1025056
TI  - The malpractice crisis.

PMID- 1025057
TI  - FMGs: a case of retributive justice.

PMID- 1025058
TI  - Overbedding the suburbs.

PMID- 1025059
TI  - Economic crisis.

PMID- 1025061
TI  - Medication error reports.

PMID- 1025060
TI  - Educating patients on spinal cord injury unit for self-medication.

PMID- 1025062
TI  - What are you doing about poor labeling of injectables.

PMID- 1025063
TI  - Current status of pharmacy services in large hospitals.

PMID- 1025064
TI  - No trade names for cancer chemotherapy agents.

PMID- 1025065
TI  - Implementation of a fundamental training program for hospital pharmacy
      technicians.

PMID- 1025068
TI  - Medication error reports.

PMID- 1025067
TI  - An innovative approach to methadone distribution in a psychiatric hospital.

PMID- 1025069
TI  - Medication error reports.

PMID- 1025070
TI  - A communications method for pharmacists in a decentralized unit dose system.

PMID- 1025071
TI  - A method of documenting drug-related problems to improve pharmacy service.

PMID- 1025072
TI  - Drug counselling with the aid of a drug education monograph.

PMID- 1025073
TI  - The role of the pharmacist in helping the alcoholic patient during recovery.

PMID- 1025074
TI  - The psychodynamics of neurotic depression.

PMID- 1025075
TI  - Psychotherapy of the depressive character.

PMID- 1025076
TI  - Dependency-self-esteem-clinical depression.

PMID- 1025077
TI  - An intrapsychic-interpersonal theory of depression.

PMID- 1025078
TI  - Depression: some updated thoughts.

PMID- 1025079
TI  - Psychoanalysis and anthropology: some considerations.

PMID- 1025080
TI  - To believe or not to believe.

PMID- 1025081
TI  - Cultural aspects of transference and countertransference revisited.

PMID- 1025082
TI  - Simultaneous analysis of child and parent by the same analyst.

PMID- 1025084
TI  - The humane society.

PMID- 1025083
TI  - On the psychosexual development of the female child.

PMID- 1025085
TI  - Presidential address.

PMID- 1025086
TI  - Basic rehabilitation nursing techniques: a cooperative hospital/medical school
      model for continuing education.

PMID- 1025087
TI  - Predicting academic success in allied health curricula.

PMID- 1025088
TI  - The health field concept. Its implications for educating health professionals.

PMID- 1025089
TI  - Use of a Biographical Data Inventory to identify behavioral correlates of
      practicing medical technologists: an exploratory study.

PMID- 1025090
TI  - Potential patterns: drug administration.

PMID- 1025091
TI  - Solving the 1976 health issues today.

PMID- 1025092
TI  - Acupuncture in the People's Republic of China.

PMID- 1025093
TI  - Institutional linkage for training health technicians.

PMID- 1025094
TI  - Highlights in the evolution of hospital-based patient education programs.

PMID- 1025096
TI  - Health services developments: innovative strategies in the People's Republic of
      China.

PMID- 1025095
TI  - Planning for educating allied health personnel in Minnesota: the first steps in a
      major project.

PMID- 1025097
TI  - A curriculum for faculty.

PMID- 1025098
TI  - Barefoot doctors and health care in China.

PMID- 1025099
TI  - Vaccines, poliomyelitis, and the Guillain-Barre syndrome.

PMID- 1025100
TI  - The diagnostic dilemma of allergic and non-allergic rhinitis.

PMID- 1025101
TI  - The neglect and abuse of children.

PMID- 1025102
TI  - Treatment of bronchial asthma.

PMID- 1025103
TI  - Provocative testing for food allergy diagnosis.

PMID- 1025104
TI  - Report on small vessel changes in the diabetic heart.

PMID- 1025105
TI  - Platelet adhesiveness in cases of diabetes mellitus before and after antidiabetic
      drugs.

PMID- 1025106
TI  - Technetium-99m uptake in the assessment of hyperthyroidism.

PMID- 1025107
TI  - Gastric secretory response to pentagastrin in normals and peptic ulcer subjects.

PMID- 1025108
TI  - A preliminary study of serum aldolase level in hepatic amoebiasis.

PMID- 1025109
TI  - Hepatocellular function in thalassaemia.

PMID- 1025110
TI  - Disseminated intravascular coagulation in cases of snake bite (Echis carinatus).

PMID- 1025111
TI  - Beta adrenergic blockade in hypertension.

PMID- 1025112
TI  - Serum amino-acids in cases of pellagra.

PMID- 1025113
TI  - Diabetes and platelet adhesiveness.

PMID- 1025114
TI  - Technetium uptake studies in thyroid diseases.

PMID- 1025115
TI  - Arachnodactyly, aminoaciduria, congenital cataract, cerebellar ataxia and delayed
      developmental milestones--a new cerebro-oculo-renal syndrome?

PMID- 1025116
TI  - Memory impairment with ethambutol (a case report).

PMID- 1025117
TI  - Congenital hereditary nystagmus with head nodding.

PMID- 1025118
TI  - Significance of gastric mucin in the aetiopathogenesis of chronic duodenal ulcer.

PMID- 1025119
TI  - Serum creatine phosphokinase in tetanus.

PMID- 1025120
TI  - Clinical trail with clonidine hydrochloride.

PMID- 1025121
TI  - Bladder and renal dysfunctions in non traumatic paraplegia.

PMID- 1025122
TI  - Clonidine in hypertension.

PMID- 1025123
TI  - Bladder and renal dysfunction in paraplegia.

PMID- 1025124
TI  - Toxoplasmosis.

PMID- 1025125
TI  - Bacteremia due to Salmonella arizonae.

PMID- 1025126
TI  - Complete congenital absence of left pericardium.

PMID- 1025127
TI  - Uncommon presentation of toxoplasmosis--a case report.

PMID- 1025128
TI  - Thymectomy in myasthenia gravis.

PMID- 1025129
TI  - Is the central nervous system ever involved in muscular dystrophy?

PMID- 1025130
TI  - Psychiatric aspects of haemodialysis.

PMID- 1025131
TI  - Study of albumin metabolism in Indian nephrotics.

PMID- 1025132
TI  - Serum magnesium in hepatic diseases.

PMID- 1025133
TI  - Role of kidney in protein kinetics.

PMID- 1025134
TI  - A new look at transposition of great arteries.

PMID- 1025135
TI  - Neurotoxic snake bite--dramatic recovery following neostigmine therapy.

PMID- 1025136
TI  - Inferior vena caval obstruction. Some unusual manifestations in a case.

PMID- 1025137
TI  - Hereditary nephritis--a family study.

PMID- 1025138
TI  - Intravenous congo red test in pulmonary tuberculosis for detection of
      amyloidosis, its value and limitations.

PMID- 1025139
TI  - Clonidine in the treatment of hypertension.

PMID- 1025140
TI  - Studies on pseudocholinesterase in patients with coronary artery disease.

PMID- 1025141
TI  - Systemic lupus erythematosus.

PMID- 1025142
TI  - Evaluation of peritoneal biopsy and ascitic fluid examination in the etiological
      diagnosis of ascites.

PMID- 1025143
TI  - An epidemiological and neuropsychiatric study of writers cramp.

PMID- 1025144
TI  - Hepatitis B antigen and hepatic cirrhosis in tropics.

PMID- 1025145
TI  - Arsenic content of drinking water in villages in Northern India. A concept of
      arsenicosis.

PMID- 1025146
TI  - Auto-immunity and diabetes.

PMID- 1025147
TI  - Serum enzymes in ischemic myocardial injury.

PMID- 1025148
TI  - Cirrhosis: "portal" and "post necrotic".

PMID- 1025149
TI  - Tuberculosis of colon--common or uncommon.

PMID- 1025150
TI  - Tubercular colitis simulating ulcerative colitis.

PMID- 1025151
TI  - Broncho-biliary fistula. (An unusual presentation of hepatic hydatid cyst).

PMID- 1025152
TI  - Membrane specializations of dentritic spines and glia in the weaver mouse
      cerebellum: a freeze-fracture study.
AB  - Electron microscopy of thin-sectioned and freeze-fractured preparations of the
      cerebellum of the weaver mouse indicates that the dendritic spines are
      morphologically identical to those of their normal littermates. The weaver
      dendritic spines have been characterized as "unattached" since the synaptic input
      from the parallel fibers is absent (8-10). The entire region around the dendritic
      spines is taken up by astrocytic processes in the weaver. The outer fracture face
      of a normal dendritic spine contains aggregations of 10-nm wide particles in the
      immediate postsynaptic region. Similar particle aggregations occur in the
      unattached spines of the weaver. Freeze-fracture preparations reveal rectilinear
      arrays of particles, having a 7-nm center-to-center distance in the glial
      membranes. Rectilinear arrays are apparently distributed throughout the astrocyte
      membrane.

PMID- 1025153
TI  - A filamentous cytoskeleton in vertebrate smooth muscle fibers.
AB  - There are three classes of myofilaments in vertebrate smooth muscle fibers. The
      thin filaments correspond to actin and the thick filaments are identified with
      myosin. The third class of myofilaments (100 A diam) is distinguished from both
      the actin and the myosin on the basis of fine structure, solubility, and pattern
      of localization in the muscle fibers. Direct structural evidence is presented to
      show that the 100A filament constitute an integrated filamentous network with the
      dense bodies in the sarcoplasm, and that they are not connected to either the
      actin or myosin filaments. Examination of (a) isolated dense bodies, (b) series
      of consecutive sections through the dense bodies, and (c) redistributed dense
      bodies in stretched muscle fibers supports this conclusion. It follows that the
      100-A filaments complexes constitute a structrally distinct filamentous network.
      Analysis of polyacrylamide gels after electrophoresis of cell fractions that are
      enriched with respect to the 100-A filaments shows the presence of a new muscle
      protein with a molecular weight of 55,000. This protein can form filamentous
      segments that closely resemble in structure the native, isolated 100-A filaments.
      The results indicate that the filamentous network has a structure and composition
      that distinguish it from the actin and myosin in vertebrate smooth muscle.

PMID- 1025154
TI  - Reversibility of cell surface label rearrangement.
AB  - Cell surface labeling can cause rearrangements of randomly distributed membrane
      components. Removal of the label bound to the cell surface allows the membrane
      components to return to their original random distribution, demonstrating that
      label is necessary to maintain as well as to induce rearrangements. With scanning
      electron microscopy, the rearrangement of concanavalin A (con A) and ricin
      binding sites on LA-9 cells has been followed by means of hemocyanin, a visual
      label. The removal of con A from its binding sites at the cell surface with alpha
      methyl mannoside, and the return of these sites to their original distribution
      are also followed in this manner. There are labeling differences with con A and
      ricin. Under some conditions, however, the same rearrangements are seen with both
      lectins. The disappearance of labeled sites from areas of ruffling activity is a
      major feature of the rearrangements seen. Both this ruffling activity and the
      rearrangement of label are sensitive to cytochalasin B, and ruffling activity,
      perhaps along with other cytochalasin-sensitive structure, may play a role in the
      rearrangements of labeled sites.

PMID- 1025155
TI  - Fusion of the envelope of mucous droplets with the luminal plasma membrane in
      acinar cells of the cat submandibular gland.
AB  - The release of mucus from acinar cells of the cat submandibular gland was
      examined by electron microscopy. The limiting membrane of mucous droplets fuses
      with the luminal plasma membrane to form a five-layered contact. This is
      converted to a three-layered membrane (unit membrane) by avulsion of the
      plasmalemma. Attenuation and rupture of this membranous barrier permits the
      contents of the mucous droplets to flow into the lumen.

PMID- 1025156
TI  - Concanavalin A induces microtubule assembly and specific granule discharge in
      human polymorphonuclear leukocytes.
AB  - Human neutrophils stimulated by concanavalin A (Con A, 100 microng/ml) contained
      markedly enhanced numbers of microtubules and discharged peroxidase-negative
      (specific) but not peroxidase-position (azurophile) granules. Release of lysozyme
      from specific granules was dose and time dependent, could be inhibitied by alpha
      methyl-D-mannoside, and enhanced by cytochalasin B. Many microtubules were
      associated with internalized plasma membrane bearing Con A binding sites.

PMID- 1025157
TI  - In vivo induction of tight junction proliferation in rat liver.
AB  - The chronic administration of phalloidin induces an extensive development of
      tight junctions between rat hepatocytes. The junctional strands lose their
      predominantly parallel orientation with respect to the canalicular lumen and
      extend abluminally in irregular patterns which cover large membrane areas at
      considerable distance from the bile canaliculi. These changes indicate both
      proliferation and provide further evidence that these junctions are not permanent
      differentiations of the cell membrane.

PMID- 1025158
TI  - [Inhibition of RNA synthesis by propyl gallate in an RNA-polmerase system].

PMID- 1025159
TI  - [Problems of regulated antibiotic biosynthesis].

PMID- 1025160
TI  - Alkaline and acid ribonucleases of the saliva and salivary glands of rats in
      postnatal ontogeny.

PMID- 1025161
TI  - [Survivability and diagnostic properties of yeasts after lyophilization and
      storage].

PMID- 1025162
TI  - [Antigenic properties of TMY protein and its polymers].

PMID- 1025163
TI  - A training sequence for low vision patients.
AB  - A structured training program for teaching low vision patients to efficiently use
      their optical aids for reading tasks is presented. The arguments for the use of
      this particular training sequence is supported through the sample patient
      histories. The training sequences can be developed in any low vision practice and
      the materials are readily available. The importance of training in a low vision
      program is emphasized.

PMID- 1025164
TI  - The teacher/doctor coordinating form--an instrument in rehabilitation of the
      partially sighted child.

PMID- 1025165
TI  - A low vision screening clinic.

PMID- 1025167
TI  - Low vision applications for programmable pocket calculators.

PMID- 1025166
TI  - Eccentric viewing training.
AB  - Eccentric viewing training seeks to train subjects to utilize a paramacular area
      of the retina for seeing when the macular area is damaged. The present paper
      demonstrates two techniques for training eccentric viewing, as well as a method
      for measuring impovement in the use of the paramacular area. Both techniques are
      inexpensive, can be administered by a technician, and do not require an extensive
      training period. However, there are indications the two techniques are not
      comparable in effectiveness.

PMID- 1025168
TI  - Low achieving child.

PMID- 1025169
TI  - The influence of visual field testing procedure on blind spot size.
AB  - Blind spots as measured by three different testing instruments were shown to be
      significantly different. These size variations seem to be related to the target
      contrast provided by the instrumentation. The need for instrument standardization
      in perimetry is discussed.

PMID- 1025170
TI  - Accommodation and vergence with the Brewster stereoscope.
AB  - In this paper, formulas are derived to determine the accommodative and vergence
      stimuli for any target or patient in a Brewster type stereoscope. Using these
      formulas, tables have been prepared that will allow the clinician to quickly
      determine the stimuli to accommodation and vergence for any given patient and
      target situation.

PMID- 1025171
TI  - Effect of corneal lens fenestration on edema and spectacle blur.
AB  - This paper is a clinical discussion of the effects of corneal lens fenestration
      on visible corneal edema and spectacle blur. Most of the discussion centers about
      photo slit lamp material selected to illustrate some of the author's experience
      with the subject. Although everyone does not benefit from fenestration,
      photographs show several cases in which visible corneal edema is reduced. Among
      patient impressions, the outstanding benefit is reduction of spectacle blur.

PMID- 1025172
TI  - The automatic occluder, a new concept.
AB  - An electro-mechanical occluder is described for use in treating problems of
      binocular vision. A number of methods of achieving the automatic occluder goal
      are reviewed. Early results of clinical studies now in progress indicate that the
      "autocluder" has unique clinical usefulness.

PMID- 1025173
TI  - Case report: the pseudo-Argyll-Robertson pupil.

PMID- 1025174
TI  - Complete optometric care.

PMID- 1025175
TI  - Nystagmus and soft lenses.

PMID- 1025185
TI  - Procedures to correct hallux abducto valgus and metatarsus primus adductus.
AB  - Four procedures are presented to correct hallux abducto valgus and metatarsus
      primus adductus in the child between the ages of 3 and 7 years. A new procedure
      is introduced: a subtalar extra-articular lateral arthroereisis, and an erasure
      procedure of the epiphysis is discussed. An important new concept in pediatric
      podiatry is introduced: it is often possible to prevent major surgery in the
      adult by performing a minor procedure in the young child. Finally, a Reverdin's
      procedure to correct the articular set angle in adults is presented.

PMID- 1025186
TI  - Metastatic adenocarcinoma of the calcaneus: case report.

PMID- 1025187
TI  - Peroneus longus tendon lengthening as an adjuvant measure in cavus foot surgery.
AB  - Lengthening of the peroneus longus tendon is very important when performing cavus
      foot surgery. This tendon directly affects all three components (varus heel,
      increased arch height, and forefoot adduction) of the idiopathic cavus foot which
      can be accounted for by increased strength and activity of the peroneus muscle.
      The deforming force is removed or weakened according to the degree, duration and
      rigidity of the cavus foot by lengthening or transferring the tendon.

PMID- 1025188
TI  - Postsurgical management of the runner.
AB  - After surgery, it is very important for a runner to maintain foot and leg
      flexibility and muscle strength. Isometric exercises, the type of muscular
      contractions that occur when the ends of the muscles are fixed (so activity is
      evidenced by increase in tension without change in length), are very useful as
      they develop power and strength and help in regaining power and strength lost by
      injuried muscles. Isometrics are of greater value when performed in several daily
      sessions instead of once a day.

PMID- 1025189
TI  - Polydactylism--dural halluces.
AB  - This type of deformity does not appear often in any podiatric practice. An
      adequate regimen should be used to reduce deformity and, hopefully, to improve,
      or at least maintain, adequate function.

PMID- 1025190
TI  - Actinomyces of the hallux: a case report.

PMID- 1025191
TI  - Cavernous hemangioma of the foot.

PMID- 1025192
TI  - The prevention of wound infections with the use of local antibiotics.
AB  - The local use of kanamycin, a broad spectrum antibiotic, has been successful in
      preventing primary wound infections. There have been no instances of drug
      reaction or sensitivity when kanamycin is used as a dilute topical irrigating
      solution. Secondary wound infections, which occurred in two cases, responded to
      local and systemic antibiotic therapy. Kanamycin can be recommended as an
      effective and safe topical antibiotic to prevent wound infections in foot
      surgery.

PMID- 1025193
TI  - Osteochondritis dissecans of the talus: discussion and case report.
AB  - A brief discussion of the salient clinicopathologic features of an entity known
      as osteochondritis dissecans and an illustrative case have been presented. High
      quality radiographic studies are of prime importance in formulating the
      diagnosis. Successful treatment of this relatively uncommon lesion can be
      provided once a thorough evaluation is made.

PMID- 1025194
TI  - Melanotic whitlow: a case report.

PMID- 1025195
TI  - Recurrent dislocation of first metatarsophalangeal joint: a case report.

PMID- 1025196
TI  - Triple arthrodesis.
AB  - Arthrodesis, the surgical fusion of a joint or joints when motion is undesirable,
      is one of the most exacting surgical procedures performed on the foot. In this
      article, the authors discuss arthrodesing techniques from the earliest attempts
      in 1878 to the more sophisticated and more successful corrective procedures of
      the present day. Their preference of the two surgical techniques used for triple
      arthrodesis is the method which involves two incisions--a 12-cm. incision on the
      medial aspect of the foot and an 8-cm. incision on the lateral aspect of the
      foot.

PMID- 1025197
TI  - Anterior entrapment syndromes.
AB  - The anterior tarsal tunnel syndrome is best described as a chronic irritation or
      compression of the deep peroneal nerve. The pathogenesis, etiology, and
      diagnostic features of the anterior tarsal tunnel as it effects the foot are
      discussed with its complexities. Case histories are presented.

PMID- 1025198
TI  - Clinical laboratory studies for the podiatric surgical patient.
AB  - Doctor Arden emphasizes the mimportance of the preoperative history and physical
      examination, including clinical laboratory studies, on all podiatric surgical
      patients. He discusses the complete blood count, coagulation studies, blood
      chemistry, serologic tests for syphilis, and urinalysis. These clinical studies
      may give evidence of undetected disease which could have a major impact on the
      surgery to be performed.

PMID- 1025199
TI  - Chondromyxoid fibroma: a case report.

PMID- 1025200
TI  - [Organization of a gynecology-obstetrics unit. Work of the permanent commission
      of the Federation for structuring these services in a gynecology-obstetrics
      hospital].

PMID- 1025201
TI  - [Duration of maternity stay].

PMID- 1025202
TI  - [Economics concerning length of maternity stay].

PMID- 1025203
TI  - [The gonadotropic hypothalamus. I. Recent findings on the anatomy and histo
      physiology of the hypothalamus].

PMID- 1025204
TI  - [The gonadotropic hypothalamus. III. Prolactin and the control of reproductory
      function in women].

PMID- 1025205
TI  - [Infections of maternity and pregnancy. Toxoplasmosis].

PMID- 1025206
TI  - [Fetoscopy].

PMID- 1025207
TI  - [Hormone receptors in cancer of the breast].

PMID- 1025208
TI  - [Fetal respiratory movements in utero].

PMID- 1025209
TI  - [Resuscitation of the fetus in utero].

PMID- 1025210
TI  - [Electrocoagulation of the cervix].

PMID- 1025211
TI  - A point of view on performance research.

PMID- 1025213
TI  - Recent birth rate decline and quality of the population.

PMID- 1025212
TI  - Health hazard among cash register operators and the effect of improved working
      conditions.
AB  - The health condition of female cash register operators in relation to their
      working conditions was investigated. A questionnaire study revealed that cash
      register operators more frequently complained of general fatigue, headache,
      sleeplessness, and low back pain than female office machine operators or other
      female workers. Dullness and pain in the shoulder, arm, hand, and fingers
      especially on the right side were characteristic of cash register operators.
      Physical examinations in 1973 showed that 31.3% of 371 cash register operators
      suffered from muscle rigidity or tenderness; 13 were severely afficted and, 69
      operators had to be either laid off, reassigned to other jobs, or given shorter
      working hours. Occupational cervicobrachial disorders were suggested to have been
      caused by repetitive upper limb motions combined with static load, an unfavorable
      working environment, and mental stress. Implementation of some improvements
      including shorter operation time, worker rotation, and adoption of electronic
      registers proved effective in reducing the number of sufferers of cervicobrachial
      disorders found during the 1975 physical examinations. But the improvements were
      not effective enough to alleviate fatigue of the neck, shoulder, and back due
      presumably to sustaining upper limbs while operating the keyboard.

PMID- 1025214
TI  - Shoes as a necessity for children.

PMID- 1025215
TI  - Sporotrichosis in Assam (a clinical and mycological study).

PMID- 1025216
TI  - Tuberculosis control and need for vigilance.

PMID- 1025217
TI  - Some observations on haemorrhagic smallpox (Type I).

PMID- 1025218
TI  - General practitioner on the scene of hyperacute myocardial infarction.

PMID- 1025219
TI  - Diabetes in pregnancy.

PMID- 1025220
TI  - Management of trophic ulcers in leprosy patients.

PMID- 1025221
TI  - Strangulation of penis by metal ring.

PMID- 1025222
TI  - Environmental pollution.

PMID- 1025223
TI  - Assessment of conservative and operative methods of treatment for vertebral
      tuberculosis.

PMID- 1025224
TI  - Histological studies of rat liver after homologous hepatocyte administration.

PMID- 1025225
TI  - Hypertension--its awareness and management on ambulatory basis.

PMID- 1025226
TI  - Pulmonary hamartoma.

PMID- 1025227
TI  - On the structure of steadily propagating rings of chemotactic bacteria.
AB  - The theoretical structure of steadily propagating cylindrically-symmetric rings
      of chemotactic bacteria is determined by solving the governing dynamical
      equations for the bacterial density distribution and the concentration of
      chemotactic agent. Accurate to first-order in the reciprocal of the radial
      distance from the axis of symmetry, the asymptotic solution obtained here can be
      employed for future comparison with measured experimental distributions.

PMID- 1025228
TI  - Elemental analysis of microareas by electron energy analyzer.

PMID- 1025229
TI  - Three-dimensional distribution of smooth endoplasmic reticulum in myelinated
      axons.

PMID- 1025230
TI  - Shift of secretory granules in the striated duct cell of the rat submandibular
      gland.

PMID- 1025231
TI  - Giemsa-SEM method to observe the surface structure of plasmocytoid cell in a
      heavy chain disease.

PMID- 1025232
TI  - Freeze-etching scanning electron microscopy with glycerinated biological tissues.

PMID- 1025233
TI  - Cutaneous schistosmal granulomatous lesions.

PMID- 1025234
TI  - On the larval trematodes recovered from Bulinus truncatus in Assiut Governorate.
      Part II. Leptocercous and amphistome cercariae.

PMID- 1025235
TI  - Chromosomal aberrations after prolonged blood donation.

PMID- 1025236
TI  - Incidence of Toxocara canis and Toxocara cati infections among stray dogs and
      cats in Cairo and Giza Governorates, A.R.E.

PMID- 1025237
TI  - Complement-fixing antibodies against Abu Hammad and Abu Mina viruses in mammalian
      sera from Egypt.

PMID- 1025238
TI  - Larval trematode stages in Bulinus truncatus and Biomphalaria alexandrina snails.

PMID- 1025239
TI  - The normal and bilharzial liver, pathology of irradiation.

PMID- 1025240
TI  - Toxocara canis as a cause of blindness in Egyptian children.

PMID- 1025241
TI  - An environmental and medical study of byssinosis and other respiratory symptoms
      in the flax textile industry of Egypt.

PMID- 1025242
TI  - The prevalence of hypertension, diabetes and ischemic heart disease, their blood
      lipids and cholesterol in different social groups in Egypt.

PMID- 1025243
TI  - A study of the skin response to various antigens in Egyptian schistosoma patients
      (preliminary report).

PMID- 1025244
TI  - Histamine metabolism in guinea pigs chronically exposed to flax dust.

PMID- 1025245
TI  - A study of the social profile of rheumatic heart children in Cairo.

PMID- 1025246
TI  - Incidence of schistosomiasis among inhabitants of Siwa Oasis, Qena and Aswan
      Governorates, A.R.E.

PMID- 1025247
TI  - The incidence of antibodies against some influenza A and B viruses in sera
      collected at Benghazi (Libya).

PMID- 1025248
TI  - The effect of smoking on the prevalence of ischemic heart disease in Egypt.

PMID- 1025249
TI  - A serological study of toxoplasmosis in juveniles with chronic tonsillitis in
      Egypt.

PMID- 1025250
TI  - Studies on the infection with the Toxocara canis the dog ascarid among Egyptians
      in Dakahleia Governorate.

PMID- 1025251
TI  - The epidemiology of the carrier state among enterica patients in Alexandria.

PMID- 1025252
TI  - The extent of breast and bottle feeding of children in Cairo and its effect on
      their growth.

PMID- 1025253
TI  - Toxoplasmosis: serological surveys in farm and domestic animals in Egypt
      (preliminary report).

PMID- 1025254
TI  - A preliminary study for the evaluation of the primary smallpox vaccination in
      Alexandria.

PMID- 1025255
TI  - Toxocariasis in the humans and dogs of Siwa Oasis, Qena and Aswan Governorates,
      A.R.E.

PMID- 1025256
TI  - Self concept and health status in the High Institute of Nursing Cairo University.

PMID- 1025257
TI  - Antibodies to Dugbe virus in mammalian sera from Egypt.

PMID- 1025258
TI  - Some biochemical changes in guinea--pigs chronically exposed to flax dust.

PMID- 1025259
TI  - Toxocariasis, transmision of and predisposition to infection.

PMID- 1025260
TI  - [The genetics of congenital glaucoma: a study of 231 cases].

PMID- 1025261
TI  - [Familial blepharophimosis and female sterility: pleiotropism or linked genes?].

PMID- 1025262
TI  - [Groenouw type II keratitis: Sicilian isolate, probable consanguinity, autosomal
      recessive transmission].

PMID- 1025263
TI  - [3 cases of the leventine disease].

PMID- 1025264
TI  - [Rothmund's syndrome: observations in one case].

PMID- 1025265
TI  - [The embryology of the internal ear].

PMID- 1025266
TI  - [The natural history of the ear in 6 drawings].

PMID- 1025267
TI  - [Hereditary deafness and genetic counseling].

PMID- 1025268
TI  - [Genetic deafness: about one hundred different mutations].

PMID- 1025269
TI  - [Genetic counseling in isolated deafness: apropos of 31 families].

PMID- 1025270
TI  - [Practical directives for the genetic counselor in cases of isolated hereditary
      deafness].

PMID- 1025271
TI  - [Evaluation of a consultation on infants with deficient hearing over the course
      of three years: genetic aspects].

PMID- 1025272
TI  - [Association between hypogonadotrophic hypogonadism and familial deafness: a
      variation of Kallmann's syndrome?].

PMID- 1025273
TI  - [Association of ocular and otological damage in an institution for the visually
      and mentally handicapped].

PMID- 1025274
TI  - [Deafness and anomalies of the lacrimal duct in a family with translocation
      t(17;22)].

PMID- 1025275
TI  - [Usher's syndrome].

PMID- 1025276
TI  - [Unilateral agenesis of the ear with facial asymmetry and vertebral anomalies (an
      incomplete form of oculo-auriculo- vertebral dysplasia)].

PMID- 1025277
TI  - [Stickler's syndrome: case report with intrafamilial variability].

PMID- 1025278
TI  - [A case of otocephaly].

PMID- 1025279
TI  - [Presentation of a case of oculo-cerebro-renal syndrome in a newborn].

PMID- 1025280
TI  - [Cat eye syndrome: chromosome study and genetic counseling].

PMID- 1025281
TI  - [Genetic counseling in cases of microphthalmos and anophthalmos].

PMID- 1025282
TI  - [Bilateral pseudo-glioma with generalized osteoporosis: an autosomal recessive
      disease].

PMID- 1025283
TI  - [The difficulties of genetic couseling in macular degeneration: the value of
      electro-oculography].

PMID- 1025284
TI  - [Hereditary optic atrophies].

PMID- 1025285
TI  - [Leber's malady: 15 cases in 4 generations--discussion of transmission].

PMID- 1025286
TI  - [The frequency of hereditary diseases in institutions for the visually
      deficient].

PMID- 1025287
TI  - [The late forms of retinoblastoma: a snare for genetic counseling].

PMID- 1025288
TI  - [Five infants with congenital cataract].

PMID- 1025289
TI  - CHAMPUS speaks on diagnosis of adolescents and third-party payors.

PMID- 1025290
TI  - A provider's view of partial hospitalization and third-party payment.

PMID- 1025291
TI  - Psychiatrists and the courts.

PMID- 1025292
TI  - A provider speaks on diagnosis of adolescents and third-party payors.

PMID- 1025293
TI  - Evaluation and comparison of four methods for plasma cortisol assay.

PMID- 1025294
TI  - Reappraisal of serum creatinine as an index of the glomerular filtration rate
      (measured by external counting).

PMID- 1025295
TI  - Indications for 131I albumin and 111In-DTPA in isotope cisternography according
      to differences in the clearance from the spinal fluid.

PMID- 1025296
TI  - Radioimmunoassay of human chorionic somatomammotropin: evaluation and comparison
      of three kit-methods.

PMID- 1025297
TI  - Radioiodine uptake test and response to treatment with methimazole in
      thyrotoxicosis.

PMID- 1025298
TI  - Radioassay of plasma cortisol: a comparison of immunological and competitive
      protein-binding methods using tritiated and 125I-radioiodinated tracers.

PMID- 1025299
TI  - Measurement of urinary free cortisol by radioimmunoassay and its clinical
      applications.

PMID- 1025300
TI  - In vivo distribution of 99mTc-labeled liposomes.

PMID- 1025301
TI  - Preparation and evaluation of tin-albumin millimicrospheres for labelling with
      99Tcm.

PMID- 1025302
TI  - Localization of a virilizing adrenal carcinoma by 131I-19-iodocholesterol
      scintigraphy.

PMID- 1025303
TI  - A simplified method of measuring free tri-iodothyronine in serum by combined
      equilibrium dialysis and gel sephadex extraction.

PMID- 1025304
TI  - On the accumulation of 67Ga in human breast milk: probable mechanism.

PMID- 1025305
TI  - Insulin kinetics after portal and peripheral injection of labelled insulin.
      Procedure to be used when no independent measure of liver plasma flow is
      available.

PMID- 1025306
TI  - [Epidemiologic approach to the problem of vaccination].

PMID- 1025307
TI  - [Hardness measure of tablets. Automatically apparatus with interchangeable head
      (author's transl)].

PMID- 1025308
TI  - [Determination of coffein in pharmaceutical raw material (author's transl)].

PMID- 1025309
TI  - [Permeability of plastic membrane to ethylene oxide (author's transl)].

PMID- 1025310
TI  - [Passive electrical constants of skeletal muscular fibres studied in different
      muscles of normal and thiamine deficient rats (author's transl)].
AB  - 10 Some effects of thiamine deficiency were studied in three skeletal rat
      muscles, having different proportions of "fast" and "slow" fibres: extensor
      longus digiti IV (a nearly pure fast muscle), soleus (having a predominant
      population of slow fibres) and diaphragm muscle (mixed fibre population). 20
      Cross section area of fibres (fig. 2) is reduced in thiamine deficient animals,
      mostly for fast fibres having a glycolytic metabolism, the histochemical profile
      of which tends to become similar to that of slow fibres, in which oxydative
      metabolism is predominant, as shown by a marked increase in succinodehydrogenase
      activity. 30 Measurements of resting potential E, of membranes time constant tau
      and of fibre input resistance R were performed in normal and thiamine deficient
      muscles (table I). R and tau were obtained from square pulse analysis, using a
      double shifted sampling method permitting the use of a single microelectrode. E
      is not greatly affected by thiamine deficiency. tau changes appear not to be
      significant, except for fast fibres from extensor longus muscle, where tau is
      slightly reduced. R is increased in thiamine deficient animals (fig. 3). 40
      Changes in R and tau do not exactly follow the predictions of cable theory, if
      one assumes that a purely dimensional factor is involved. Thus, the view that
      thiamine deficiency does not change basic passive electrical constants of fibres
      (membrane specific resistance and capacity, myoplasm resistivity) can be
      considered only as a first approximation. 50 R and tau values obtained in normal
      muscles are larger than data taken from other studies. The reasons for this
      discrepancy are discussed. It is suggested that diet differences may play a role.

PMID- 1025311
TI  - [Effect of cold exposure on synthesis of cerebral dopamine (author's transl)].
AB  - The synthesis of dopamine (DA) has been studied in the striatum and cortex of
      rats exposed to a temperature of 40C for 2.5 or 24 h. The synthesis rate has been
      estimated 30 mn after an i.v. injection of 3H tyrosine (TY), by the evaluation of
      the ratio: 3H-DA specific activity 3H-TY specific activity. Cold exposure
      modified DA synthesis differently in the two brain areas. In the striatum, DA
      synthesis was multiplied by a factor of 1.5 after 2.5 h of cold exposure and
      returned to normal value after 24 h. In the cortex, cold exposure did not
      significantly change DA synthesis (at any of the two times studied).

PMID- 1025312
TI  - Intestinal polyposis associated with oxyurid parasites in a chimpanzee (Pan
      troglodytes).
AB  - A 40-year-old male chimpanzee had multiple intestinal polyps associated with
      immature male oxyurid parasites. The gross and histologic characteristics of
      these lesions were identical to those produced by Nochtia nochti in the stomach
      and esophagus of Old World primates. It was theorized that the lesions resulted
      from hypersensitivity to oxyurid infection in an aberrant host.

PMID- 1025313
TI  - Sex, love, and the committed relationship.

PMID- 1025314
TI  - Historical and theoretical perspectives: sex, love, and commitment revisited.
AB  - A sociology-of-knowledge perspective is used to examine the interplay among sex,
      love, and commitment within the context of historical trends and social changes.
      The implications of qualitative and quantitative differences among love, sex and
      commitment are discussed in relation to (1) the concept of "multiple selves," (2)
      "individual variations in threshold levels," and (3) the misuse of "ideal types."
      Clinical and research efforts to differentiate among sex, love, and commitment
      need to be balanced by explicit awareness of the tendency to compartmentalize
      these three areas.

PMID- 1025315
TI  - Clincal observations of sex as a reverberation of the total relationship.
AB  - In the psychiatric treatment of sexual dysfunctioning the generally accepted
      method has been to concentrate heavily on the intrapsychic conflicts of one or
      both spouses. There now is increasing evidence that treatment is sometimes more
      effective if the therapeutic intervention takes place directly in the
      interpersonal system. Such evidence has been provided by those therapists with
      clinical experience in marital systems who are prepared to utilize theories
      evolved from a multidisciplinary approach to marital problems. This paper is
      meant to discuss and illustrate this shift in treatment strategy as it applies to
      sexual dysfunctioning and deals with the function of the interplay of sex, love,
      and commitment through the illustrative cases.

PMID- 1025316
TI  - Audiological tests for evaluation of central auditory disorders.
AB  - Three audiological tests (Competing Sentences, Rapidly Alternating Speech,
      Staggered Spondaic Words) currently being used to evaluate central auditory
      dysfunction are discussed. Audiological and neurological findings on three
      patients with central auditory lesions are presented, with special reference to
      their performance on these central auditory tests. Results suggest the tests are
      of value in identifying and/or corroborating central lesions, and in providing a
      more complete explanation of patient communicative difficulties.

PMID- 1025317
TI  - A study of acupuncture in adult sensorineural hearing loss.
AB  - Twenty-nine adult volunteers with stable bilateral sensorineural hearing loss
      were treated by acupuncture. Subjects were randomly assigned to one of four
      experimental groups: active needling, active needling followed by sham needling,
      sham needling followed by active needling, and sham needling. All subjects
      received 30 treatments. Only one ear was treated by acupuncture. The second ear
      was kept for an intrasubject control. Prior to treatment a baseline of hearing
      was established. During the course of acupuncture, audiological assessments (pure
      tone thresholds and speech tests) were made after sets of five treatments.
      Hearing was again measured during the year following acupuncture. The results in
      individual subjects and statistical comparisons of active and sham groups showed
      that acupuncture did not produce significant shifts in hearing.

PMID- 1025318
TI  - [Diabetes and diseases of the internal ear].
AB  - The authors present a series of 30 cases of vertigo where diabetes and
      hyperlipidemia were found. The literature on the subject is reviewed, and
      evidence points to a diabetic lesion of the inner ear. Our cases illustrate that
      lesion and its clinical presentation.

PMID- 1025319
TI  - Policy statement on hearing aid delivery system.

PMID- 1025320
TI  - [Otology on a plateau].

PMID- 1025321
TI  - High-potassium induced contracture in guinea pig ureter.
AB  - Some characteristic properties of guinea pig ureter in high-K induced contracture
      were studied. The contracture was composed of three contraction components, quick
      phasic, slow transient, and substained states. The height of the second component
      decreased with time when the preparation was immersed in high-K solution. This
      was observed during a brief washing treatment with normal Tyrode solution applied
      at varius times after immersion in high-K solution. When the brief washing
      treatment was applied after 30 min, a contracture composed of the first and the
      third components was observed. Similar results were obtained in Ca-induced
      contracture of K-depolarized preparations. Fluctuations of tension were observed
      in the course of the contracture. The fluctuations could be evoked by various
      types treatments and were observed to have some relationship to extracellular Ca.
      It was indicated that extracellular Ca has an important role in the initiation of
      each component of the contracture and that the role of Ca is controlled by the
      cell membrane.

PMID- 1025322
TI  - [Blood calcium levels in heart defects after surgery with extracorporeal
      circulation].
AB  - The total content of calcium and protein was studied in 50 patients during the
      initial 5 days after surgery for their congenital or acquired heart diseases
      conducted under extracorporeal circulation; in half of them the content of the
      dialysing fraction of total calcium and plasma albumins were also examined. The
      study has demonstrated that during the 1st postoperative day the content of the
      total and dialysing calcium is elevated which is due to the administration of
      calcium for the neutralization of citrate during blood transfusions. The greatest
      fluctuations of these values (both decreases and increases) were observed when
      the heart-lung machine was primed with blood containing 18.2--23mEg Ca++ per 1 1
      of citrate blood. Within the early 5 postoperative days no restoration of the
      impaired calcium balance is observed in these patients, while the blood content
      of calcium is returning to the preoperative level. The blood content of calcium
      was studied after repeated injections of various doses of calcium. The most
      rational method proved to consist in repeated injections of 5ml of 10% CaCl2
      solution every 30 min--1 hour which resulted in a moderate elevation of the blood
      content of the total and dialysing calcium.

PMID- 1025323
TI  - [Study of carbohydrate metabolism in rats after administration of myocardium
      damaging doses of adrenaline].
AB  - The investigation included a study of the content of glycogen, of the activity of
      the enzymes of its decay (phosphorylase and hydrolytic enzymes), of the content
      of lactic acid, and glucose in rats following the administration of myocardium
      damaging doses of adrenalin, as well as in animals who had died after the
      administration of adrenalin or were agonizing. The analysis of the carbohydrate
      metabolism parameters in animals who had died due to the adrenalin
      administration, or who had been sacrificed in an agonizing state (sharp fall of
      the glycogen content in the heart, increased activity of hydrolytic enzymes in
      the heart during the agonizing phase) indicated that the temporary elevation of
      the glycogen content in the heart after the administration of 300microng/100g of
      adrenalin was a compensatory reaction of the body. It is suggested that a certain
      relationship exists between the markedness of this compensatory reaction, i.e.
      the glycogen level in the heart muscle, and the severity of necrotic lesions.

PMID- 1025324
TI  - [Changes of the red blood indicators in the acute period of myocardial infarct].

PMID- 1025325
TI  - [Hemodynamic indicators in patients with primary rheumocarditis].

PMID- 1025326
TI  - [Hemodynamic characteristics of the stages of mitral valve stenosis].

PMID- 1025327
TI  - [Contractile function of the myocardium in mitral valve stenosis associated with
      arterial hypertension].

PMID- 1025328
TI  - [Pathogenesis of neurocirculatory asthenia].

PMID- 1025329
TI  - [Prognosis of work capacity in the system of rehabilitation of patients with
      myocardial infarct].
AB  - The possibilities of prognosing with regard to the capacity for work within the
      1st year of resuming working were studied in the system of rehabilitation of
      myocardial infarction patients. The prognostic value of several items was
      determined that characterize the state of the patient prior to his myocardial
      infarction, the course of the acute phase, and the state in the postinfarction
      period prior to resuming working. The informativeness of several sets of items
      was determined along with the relative informativeness of a certain single item,
      with that of a group of other items known. It was demonstrated that in
      determining the capacity for work the leading items should be conside

PMID- 1025330
TI  - [Intensive care units for patients with acute coronary insufficiency].

PMID- 1025331
TI  - [Pathogenesis of the gastrointestinal syndrome in myocardial infarct].

PMID- 1025332
TI  - [State of the coronary bed and certain indicators of hemodynamics and myocardial
      contraction in auricular fibrillation].
AB  - Selective coronary angiography was performed and cardiac catheterization was
      employed to study the indices of the myocardial contractility and the state of
      central haemodynamics in 20 patients with ischaemic heart disease, 24 patients
      with myocarditic cardiosclerosis complicated by cardiac fibrillation, 6 patients
      with "idiopathic" atrial fibrillation, and 20 patients with extracardiac
      pathology (controls). The data obtained by the author indicate that selective
      coronary angiography helps significantly in the differential diagnosis between
      myocarditic cardiosclerosis and ischaemic cardiomyopathy.

PMID- 1025333
TI  - [Molecular mechanisms of cardiac insufficiency in myocardial ischemia].
AB  - An analysis of the main concepts of the pathogenesis of heart muscle
      insufficiency under ischaemia was conducted. None of the hypotheses postulating
      the invariability of the energy supply to the myofibrills was shown to explain
      the fast reduction of the contractility of the ischaemic myocardium. These
      hypotheses are based on the experimental fact of the ATP level in the myocardium
      practically undergoing no reduction under ischaemia. At the same time, one of the
      earliest changes in the heart muscle under ichaemia consists in creatine
      phosphate concentration reduction that correlates with the decrease in the
      contractility. The recently obtained data indicate that the energy synthesized in
      the mitochondria of the cardiac muscle is carried away from them in the form of
      energy of creatine phosphate molecules that is later used for ATP synthesis in
      the myofibrill creatine phosphokinase reaction. A scheme is suggested that
      implies that under ischaemia severe changes in the energy supply consisting in
      creatine phosphate synthesis reduction are the leading factor in the pathogenesis
      resulting on the early stages of the process in a reduction of the contractility,
      and on the later ones--in irreversible damages of the membrane systems and cell
      destruction.

PMID- 1025334
TI  - [Disseminated intravascular coagulation in myocardial infarct].
AB  - In patients with angina pectoris and acute myocardial infarction different signs
      of disseminated intravascular coagulation were found, their intensity depending
      on the severity of the clinical course. In myocardial infarction with a
      complicated course and, especially, in shock signs of disseminated intravascular
      microthrombus formation were revealed, its criteria including, according to the
      author's data, reduced platelets count, factor V activity, shortening of
      platelets life and period of labelled fibrinogen circulation, appearance of large
      quantities of the fibrin-monomer complex.

PMID- 1025335
TI  - [Evaluation of the adrenal cortex function in patients with acute myocardial
      infarct by means of radioisotope micromethods].
AB  - Employing modern radio-isotope techniques of hormone examinations (that of
      competitive protein binding for hydrocortisone determinations, and the
      radioimmunoassay for progesterone and aldosterone determinations in the
      peripheral blood), 102 patients with acute myocardial infarction were examined.
      It is concluded that a comprehence study of the functional state of the adrenals
      in patients with myocardial infarction with the employment of radio-isotope
      techniques will permit to reveal some additional mechanisms of the pathogenesis
      of myocardial infarction and its complications, and to be guided in the choice of
      rational therapy.

PMID- 1025336
TI  - [Intrahepatic hemodynamics and liver function in the acute period of myocardial
      infarct].
AB  - Data are presented on the state of the intrahepatic blood flow and the absorption
      excretory capacity of the liver in 221 patients with acute myocardial infarction.
      The changes in the absorption-excretory function of the liver and of the hepatic
      blood circulation are described on the basis of a dynamic observation (on the
      1st, 20--30th, 50--60th day of the onset of the disease) and with due regard of
      the extent of the myocardial infarction and the presence of complications,
      cardiogenic shock in particular.

PMID- 1025337
TI  - [Study of the contractile function of the myocardium with the aid of
      echocardiography].
AB  - The problems of studying the contractile function of the myocardium were
      investigated in patients with acquired heart diseases and varying stages of
      circulation insufficiency. Echocardiography was used to examine 92 patients, aged
      17 to 38 years. The results of the examination permitted to obtain a clear
      understanding of the degree of changes in the myocardium contractile function.
      The most valuable parameters of echocardiogrammes which permit to record the
      early signs of cardiac insufficiency include the myocardium excursions rate, the
      ejection fraction, the contraction rate of the circular fibers of the myocardium,
      the percentage of shortening the anterior-posterior dimensions of the left
      ventricle.

PMID- 1025338
TI  - [Contractile function of the left ventricle after myocardial infarct, according
      to echocardiographic data].

PMID- 1025339
TI  - Recombinant influenza-virus vaccines: I. Rapid derivation and preliminary
      characterization of high-yielding recombinants of influenza virus.

PMID- 1025340
TI  - Recombinant influenza-virus vaccines: II. Some properties of high-yielding
      recombinant influenza viruses and their vaccines.

PMID- 1025341
TI  - Studies on the development of a live attenuated mumps virus vaccine. II.
      Development and evaluation of the live "Hoshino" mumps vaccine.

PMID- 1025342
TI  - On the factors affecting the initiation of protein synthesis in the rat ventral
      prostate: androgens, polyamines and conjugated proteins.

PMID- 1025343
TI  - In vitro binding and metabolism of androgens in various organs: a comparative
      study.

PMID- 1025344
TI  - Effects of ESH and testosterone on the RNA synthesis in different stages of rat
      spermatogenesis.

PMID- 1025345
TI  - A molecular analysis of the human estrogen receptor.

PMID- 1025346
TI  - Specific [3H]-estradiol binding in the fetal uterus and testis of guinea pig.
      Quantitative evolution of [3H]-estradiol receptors in the different fetal tissues
      (kidney, lung, uterus and testis) during fetal development.

PMID- 1025347
TI  - Uterine receptor-estradiol complexes and their interaction with nuclear binding
      sites.

PMID- 1025348
TI  - Model systems for the study of estrogen action in tissue culture.

PMID- 1025349
TI  - The properties and functional significance of ATP binding to progesterone
      receptors.

PMID- 1025350
TI  - Progestin receptors in human tissues: concentrations and binding kinetics.

PMID- 1025351
TI  - Calorimetric approach to the study of 5alpha-dihydrotestosterone and estradiol
      receptors in rat hypothalamus cytosol.

PMID- 1025352
TI  - The 'estrogen-induced protein': quantitation by autoradiography of polyacrylamide
      gels.

PMID- 1025353
TI  - Estrogen receptors and ovalbumin genes in hen oviduct chromatin fractions.

PMID- 1025354
TI  - Role of nuclear proteins as high affinity sites ("acceptors") for progesterone in
      the avian oviduct.

PMID- 1025355
TI  - Effect of progesterone on HnRNA and avidin mRNA of the chick oviduct.

PMID- 1025356
TI  - Activation of transcription-regulating proteins by steroids.

PMID- 1025357
TI  - Kinetics of glucocorticoid-receptor complexes in rat thymus cells.

PMID- 1025358
TI  - Kinetics of steroid transport through cell membranes: comparison of the uptake of
      cortisol by isolated rat liver cells with binding of cortisol to rat liver
      cytosol.

PMID- 1025359
TI  - Glucocorticoid receptors in interstitial cells of the rat testis.

PMID- 1025360
TI  - Concanavalin A-induced glucocorticoid resistance in rat thymus cells: decreased
      cytoplasmic and nuclear receptor binding of dexamethasone.

PMID- 1025361
TI  - Glucocorticoid effects on DNA-dependent RNA polymerase activity in rat thymus
      cells.

PMID- 1025362
TI  - A review of regulation of gene expression by steroid hormone receptors.

PMID- 1025363
TI  - Steroid hormone target sites in the brain: the differential distribution of
      estrogin, progestin, androgen and glucocorticosteroid.

PMID- 1025364
TI  - Cytosol and nuclear receptors for 5alpha-dihydrotestosterone and testosterone in
      the hypothalamus and hypophysis, and testosterone receptors isolated from
      neonatal female rat hypothalamus.

PMID- 1025365
TI  - The role of receptors in the steroidal regulation of tumour cell proliferation.

PMID- 1025366
TI  - Estradiol binding and metabolism in human endometrial hyperplasia and
      adenocarcinoma.

PMID- 1025367
TI  - Steroid abnormalities in endometrial and breast carcinoma: a unifying hypothesis.

PMID- 1025368
TI  - Glucocorticoid receptors, DNA synthesis, membrane antigens and their relation to
      disease activity in chronic lymphatic leukemia.

PMID- 1025369
TI  - Hormone dependency in breast cancer.

PMID- 1025370
TI  - Androgen receptors in human pharyngo-laryngeal mucosa and pharyngo-laryngeal
      epithelioma.

PMID- 1025371
TI  - Progestational therapy in human renal carcinoma and steroid receptors.

PMID- 1025372
TI  - Urinary excretion of metabolites of steroid hormones by men with cancer of the
      stomach.

PMID- 1025373
TI  - Studies on the control of aldosterone secretion in man.

PMID- 1025374
TI  - Antihypertensive action of 18,20-cyclo-20,21-dihydroxy-4-pregnen-3-one, a
      structural analogue of 18-hydroxydeoxycorticosterone.

PMID- 1025375
TI  - Adrenocortical factors in hypertension. II The significance of 16-oxygenated C-19
      steroids.

PMID- 1025376
TI  - Regulation of plasma levels of aldosterone and its metabolites during the latent
      period of aldosterone.

PMID- 1025377
TI  - Steroids and intraocular pressure.

PMID- 1025378
TI  - A comparative study of androgen binding in rat uterus and prostate.

PMID- 1025379
TI  - The influence of steroid-receptor complexes on the stages of transcription of
      target-tissue chromatin.

PMID- 1025380
TI  - The effects of case on the processing of noun phrases.

PMID- 1025381
TI  - Syntactic and strategic aspects of the comprehension of indirect and direct
      object constructions by children.

PMID- 1025382
TI  - A measure of preference for speaking rather than writing and its relationship to
      expressive language skills in adolescents.

PMID- 1025383
TI  - Children's comprehension of metaphor: a Piagetian interpretation.

PMID- 1025384
TI  - The effect of two educated dialects on sentence repetition scores of five year
      old Scottish children.

PMID- 1025385
TI  - Verbal conditioning without awareness: a case study.

PMID- 1025386
TI  - Relationships between hesitation phenomena, anxiety, and self-control in a normal
      communication situation.

PMID- 1025387
TI  - Early acquisition of linguistic designations for time.

PMID- 1025388
TI  - Transformational complexity and sentence difficulty: a developmental study.

PMID- 1025389
TI  - ["Haec oportuit facere et illa non omittere"].

PMID- 1025390
TI  - [Myocarditis and sudden, unexpected death in childhood].

PMID- 1025391
TI  - [Changes in the incidence of squamous cell carcinoma and adenocarcinoma of the
      uterus in Perugia from 1942 to 1976].

PMID- 1025392
TI  - [So-called perioral dermatitis (author's transl)].

PMID- 1025393
TI  - [Pathologico-anatomic and clinico-laboratory characteristics of primary liver
      carcinoma (author's transl)].

PMID- 1025394
TI  - [Contents of doctor-patient talks in offices of general practitioners (author's
      transl)].

PMID- 1025395
TI  - [Current surgical therapy of duodenal ulcer] (author's transl)

PMID- 1025396
TI  - [Cat scratch disease in the cervicofacial region] (author's transl)

PMID- 1025397
TI  - [Cat fever] (author's transl)

PMID- 1025398
TI  - [Morphology of lymphogranulomatosis].

PMID- 1025399
TI  - [Roentgenocontrast methods of diagnosis of lymphogranulomatosis].

PMID- 1025400
TI  - [Radioisotope diagnosis of lymphogranulomatosis].

PMID- 1025401
TI  - [Laparotomy with splenectomy in lymphogranulomatosis].

PMID- 1025402
TI  - [Certain results and unsolved problems of diagnosis and treatment of
      lymphogranulomatosis].

PMID- 1025403
TI  - [Chemotherapy of lymphogranulomatosis].

PMID- 1025404
TI  - [Resolutions of the All-Union conference on the diagnosis and treatment of
      lymphogranulomatosis].

PMID- 1025405
TI  - [Diagnostic importance of radioisotope tests in vitro in disorders of iodine
      metabolism].

PMID- 1025406
TI  - [Diagnosis of metastatic bone lesions with the aid of Sr85].

PMID- 1025407
TI  - [Complex scientific programs and cooperative scientific studies].

PMID- 1025408
TI  - [Dosimetric characteristics of irradiation with gamma-apparatus "Rokus"].

PMID- 1025409
TI  - [Telecontrol of correlation between the working beam of radiation and radiated
      volume in radiotherapy].

PMID- 1025410
TI  - [Significance of the symptoms of intoxication in the treatment  of
      lymphogranulomatosis].

PMID- 1025411
TI  - [Liver scanning with a colloidal solution of 113MIn in tumors of the abdominal
      cavity].

PMID- 1025412
TI  - [Radioisotope inferior venocavography in tumors of the kidney and retroperitoneal
      space].

PMID- 1025413
TI  - [In vitro study of peripheral blood with thymidine-3H in the diagnosis of
      melanoma of the skin].

PMID- 1025414
TI  - [Modification of radioisotope study of kidney function].

PMID- 1025415
TI  - [Use of semiconductor detectors in broncho-radiometry for diagnosis of lung
      cancer].

PMID- 1025416
TI  - [Units of SI measurement in medical radiology].

PMID- 1025417
TI  - [MNIRRI-Gamma profile scanner].

PMID- 1025418
TI  - [Computer calculation of dose distribution when using fields with complex
      configurations].

PMID- 1025419
TI  - [252Cf in combined radiation therapy of cancer of the uterine cervix].

PMID- 1025421
TI  - [Method of clinical x-ray videometry].

PMID- 1025420
TI  - [Scintigraphy of soft tissue tumors using 75Se-methionine].

PMID- 1025423
TI  - [The problem of scientific choices].

PMID- 1025422
TI  - [Assessment of thyroid gland function using 125I during treatment of
      thyrotoxicosis with 131I].

PMID- 1025424
TI  - [Selection of power force for the electrocardiostimulating apparatus and the
      study of the characteristics of the battery "Krona VTs"].
AB  - An independent power supply of electrocardiostimulators improves the electric
      safety of the patient and of the attending staff, does not produce any additional
      interferences with the functioning of instrumentation and makes it possible to
      design mobile portable devices. The storage battery used as a power source should
      have a sufficiently great capacity, provide for some back-up time ensuring normal
      operation of the apparatus, have small dimensions and mass. These requirements
      are met with most adequately by the air-zinc battery "Krona Vts". To estimate the
      continuous operation time for the apparatus experimental characteristics of the
      battery's pulse discharge are given.

PMID- 1025425
TI  - [Errors in the lung volume measurement and its reproducibility by the method of
      helium displacement in the closed system].
AB  - On a mechanical model of the lungs systematic (constant) and accidental (random)
      errors in measuring the volume by the device (see article)-1, were determined and
      these amounted to +2.7 and identical to 2.2, respectively. The latter was three
      times as low as the mean-square reproducibility error, i.e. the degree of error
      in the physiological measurement of FRC. Different sources of errors in the
      measurement of FRC, among which particular attention is called to errors in
      defining the helium concentration at the end of the mixing process in closed
      system, are considered.

PMID- 1025426
TI  - [Complex system of quality control of the medical engineering products].

PMID- 1025428
TI  - [Main trends in the development of biomedical engineering industry in the 10th
      Five-Year Plan].

PMID- 1025427
TI  - [Ground-isolated input circuits of the electronic diagnostic apparatus as means
      of increasing electric safety of the patient].
AB  - Introduction into the medical practice of new diagnostic and therapeutic methods,
      such as electric stimulation, measurement of intracardiac blood pressure, of pH
      and others, entails possible hazards for the patient to suffer an electric
      current injury. To ensure the patient's safety during various disturbances in the
      operation of the devices certain protective measures have to be devised. On an
      example of the electrocardiograph possible methods of accomplishing complete
      isolation of the patient from the ground through separating the signal and supply
      circuits is shown.

PMID- 1025429
TI  - [Electric dental analgesia apparatus with increased stabilization of the
      operating current].
AB  - To improve the construction of the existing (formula: see text) apparatus
      intended for relief of pain during treatment of hard dental tissues a new version
      of this unit with a higher stabilization of the operating current--model
      (formula: see text) -- has been designed. In it the intensity of the current is
      adjustable within the range of 1 to 30 micronA. Power supply from the mains and
      from the storage battery "Krona" is provided for in the apparatus.

PMID- 1025430
TI  - [Ractangular sterilization boxes with filters].

PMID- 1025431
TI  - [Centralized sterilization units TsSU-1000].

PMID- 1025432
TI  - [Scientific-technical and economic cooperation in the field of biomedical
      engineering between organizations of USSR and East Germany].

PMID- 1025433
TI  - [New biomedical equipment].

PMID- 1025434
TI  - [Commutation systems of the roentgenodiagnostic apparatus operating with
      automatic exposure relays].
AB  - The automatic exposure relay (X-ray exposure meter) enables the exposure time in
      roentgenography of diverse human organs to be determined and fixed with a high
      degree of accuracy, but the subsequent protracted commutation of the main and
      control circuits of the roentgen-diagnostic apparatus tends to practically bring
      to naught this high precision. The paper deals with an analysis of commutation
      delays and lags in different control systems of the roentgen apparatus and with
      assessing the effect they have on the quality of the X-ray picture.

PMID- 1025435
TI  - [Elaboration of the structure and principles of construction of a unified system
      for the apparatus for artificial circulation].
AB  - A pertinet analysis and assessment of medico-technical and ergonomic
      characteristics, both of individual extracorporeal circulation units (ECU) and
      major functional components (pumps, oxygenators, etc) served as a background to
      suggesting a principle for establishing a unitized ECU system based on the
      functional (performance) and spatial (packaged) module.

PMID- 1025436
TI  - [Problems of thrombogenesis and destruction of the superficial layer of implanted
      artificial heart valves].
AB  - Experience with the use of artificial cardiac valves has revealed basic
      shortcomings of their designs, viz. their hemodynamic inadequacy to natural
      cardiac valves and thrombogeneity. The thrombogenesis is held to be qualitatively
      linked with the turbulence of the blood stream on the prosthesis, but the
      mechanism of this phenomenon has not been explained so far. Metallographic
      investigations of the titanium valve surfaces, with the valves having been
      operative in the human body over periods of from 8 hours to 80 days, demonstrated
      destruction of the superficial layer of the valve's cell. The surface layer of
      the metal is structurally changed to a depth of 0.05 mm, has a spongy texture and
      is readily detachable from the bulk of the metal. The presumed cause of erosion
      is considered to be saturation of the surface layer with gases, possibly as a
      result of cavitation within the prosthesis zone.

PMID- 1025437
TI  - [Artificial organs].

PMID- 1025438
TI  - [Comparative evaluation of cuprophane and cellophane used as membranes for
      hemodialysis].
AB  - Investigations into the structure, mechanical properties and permeability of the
      Soviet-made cellophane, cellulose film No 100 and cuprophane have shown the
      Soviet-made cellophane membrane to be inferior to cuprophane with regard to the
      strength and permeability of low-molecular metabolites. High strength properties
      of the cellulose film No 100 go with a much more lower permeability than in the
      case of cuprophane and cellophane. Sterilization with gamma-irradiation does not
      have any material effect on the physico-mechanical and functional characteristics
      of the membranes. Ways and means for improving the strength and permeability of
      the hydrate-cellulose membranes are outlined.

PMID- 1025439
TI  - [Electronic biocontrol unit for the assisted circulation].

PMID- 1025440
TI  - [Power units of implanted artificial heart and assisted circulation system].
AB  - The existing and presently planned systems of power supply for an artificially
      implanted heart and assisted circulation devices are reviewed. A comparative
      analysis as to their conformability to biological, functional and technical
      demands placed on the implanted systems is given. In an implanted artificial
      heart and assisted circulation systems most promising is shown to be the use of
      nuclear fuel as a source of power and as converters -- that of thermal engines
      with gas and steam cycle.

PMID- 1025441
TI  - [Synchronous mechanical heart massage during assisted circulation].
AB  - In tests on dogs specially devised cardiac massage appliances and a monitoring
      system synchronizing the mechanical massage with the R wave on the ECG were used
      in carrying out a synchronous mechanical chest massage in conditions of an
      experimentally induced incompetence of the cardiac ventricles. Optimal parameters
      of the hemodynamics were recorded with the massage proceeding in such a manner,
      when mechanical action on the cardiac ventricles coincided with termination of
      the maximum pressure period of the myocardium. The synchronous ancillary cardiac
      massage effected under conditions of ventricular incompetence was found to be
      attended by a rise of cardiac output and increased aortic pressure, falling
      tension in the auricles and normalization of the acid-base equilibrium figures.
      Synchronization of the massaging appliance operation with cardiac contractions is
      an effective method of assisted circulation in acute incompetence of the heart
      valves.

PMID- 1025442
TI  - [Components of an implanted artificial heart and the medico-technical
      requirements].
AB  - The task of designing and providing power supply for an implanted artificial
      heart (AH) is a many-sided complex problem that includes a number of medico
      biological, technical, physical, power-supply and other factors. The analysis of
      the AH components and the mentioned basic medico-technical requirements permits
      it to outline the ways and means for a rational solution of this complicated
      problem. The greatest attention is paid to the analysis of and future prospects
      for the use of different power sources and methods of power conversion.

PMID- 1025443
TI  - [Surgical cryo-ultrasonic instrument].
AB  - With the YPCK-7H unit, serving as a base, a cryo-ultrasonic instrument for a
      combined use of cryogenic and ultrasonic methods has been constructed. A pipe for
      the passage of liquid nitrogen is mounted on an ultrasonic waveguide, this
      securing the cooling of the soft tissue subjected to the operation down to--135-
      80degreesC and separation of the tissues with the frequency of ultrasonic
      oscillations within a range of 20 to 45 kHz. The surgical cryoultrasonic
      instrument is apt to significantly increase the efficacy of hemostasis and helps
      achieve a still better neatness of the cut, this obviously being due to the
      cryogenic factor which adds advantage to the ultrasonic operative intervention.

PMID- 1025444
TI  - [Medical engineering industry in the 10th Five-Year Plan].

PMID- 1025445
TI  - [Cryogenic instruments for the treatment of head and neck neoplasms].
AB  - Experience gained with the treatment of head andneck tumours with different
      cryogenic instruments, whose size and shape varied within a wide range, helped
      choose and recommend for performing a large number of operations as instrument,
      the length and diameter of whose working part measure 200 mm and 6 mm
      respectively, with the length of the freezing tip of 25 mm and the angle of its
      inclination to the axis--100--120 degrees. The presence of a warmer and of a
      holding handle makes it easy to handle.

PMID- 1025446
TI  - [Thermal tubes in cryogenic surgery].

PMID- 1025447
TI  - [Cryosurgical devices in otorhinolaryngology].
AB  - Two instruments for realization of cryosurgical treatment are proposed, viz. with
      gas and liquid systems of cooling. Nitrogen serves as a cooling agent. In devices
      a rapid interchange of tips, depending upon the kind of the operation, is
      provided for. The time necessary for making the cryodevices ready for the
      operation does not exceed 1.5 minutes.

PMID- 1025448
TI  - [Cryosurgical applicator in dermatology].
AB  - An autonomous dermatological applicator is proposed for cryological destruction
      of pathologically altered sections of the skin. It is equipped with a set of
      interchangeable tips permitting it to treat different areas of the skin. The
      temperature and the force of contact of the tip with the tissue are adjustable.
      As a refrigerant liquid nitrogen is made use of.

PMID- 1025449
TI  - [Outfit for impedance studies of the auditory function].
AB  - An apparatus for measuring the middle-ear impedance enabling it to record the
      threshold of the acoustic reflex and to measure its dynamic characteristics with
      contralateral and ipsilateral stimulation, as well as to carry out tympanometry
      of the middle ear and to judge on the ventilation function of the auditory tube
      is described. The set-up includes: a device for pressure feeding and recording in
      the external ear, an arrangement for imparting a sonic stimulus and the one for
      input and recording the air pressure.

PMID- 1025450
TI  - [Method of recording impulses from an implanted cardiostimulator].
AB  - An analysis of pulses from an implanted cardiostimulator recorded from the
      surface of the patient's body is one of the methods permitting it to pass
      judgment as to its functioning. Because of the possibility of the recording
      electrodes location coinciding with the equipotential line an erroneous
      interpretation of the cardiostimulator's condition is not to be ruled out. It is
      recommended that the pulses should be recorded with their subsequent analysis in
      no less than 2 standard ECG leads from the limbs.

PMID- 1025451
TI  - [Use of different kinds of energy in biomedical engineering].

PMID- 1025452
TI  - [Use of electroglottograph].
AB  - The most informative method of investigating the phonatoric function of the
      larynx is the one proposed by F. Fabre back in 1957. Utilization of a specially
      devised apparatus--electopharyngograph enables it to make a delicate differential
      diagnosis, to observe the patient dynamically during the treatment and to effect
      a comparative analysis of the vocal cords condition.

PMID- 1025453
TI  - [Gyneocologic curets with removable working parts].

PMID- 1025454
TI  - [Steam sterilizer GK-100-3].

PMID- 1025455
TI  - [Sunlight-protective eyeglass lenses].

PMID- 1025456
TI  - [New government standard for sunlight-protective eyeglass lenses].

PMID- 1025457
TI  - [Morphology of human liver after successful treatment of opisthorchiasis with
      chloxyl].

PMID- 1025458
TI  - [Naphthamone analogs and their anthelmintic activity].

PMID- 1025459
TI  - [Search for specific therapy of trichinellosis. 8. Aryl- and heteryl
      vinylbenzimidazoles in experimental trichinellosis of albino mice].

PMID- 1025460
TI  - [Experimental therapy of echinococcosis. 1. Laboratory model of echinococcosis
      and the effect of sarcolysinacridine, levamisole and mebendazole on the
      development of larval cysts of Echinococcus granulosus].

PMID- 1025461
TI  - [Molluscacidal and cercaricidal properties of the antibiotic phytobacteriomycin].

PMID- 1025462
TI  - [Geohelminthiasis among the population of the Yemen Arab Republic].

PMID- 1025463
TI  - [Horsefly fauna in the Pribaikal'e, the zone of construction of the Baikal-Amur
      Railway].

PMID- 1025464
TI  - [Ectoparasites of murine rodents in the buildings in Priamur'e].

PMID- 1025465
TI  - [Shelters of blood-sucking midges (Diptera, Ceratopogonidae) Culicoides
      leptoconops in the steppe zone of Ukraine].

PMID- 1025466
TI  - [Bronchial asthma and dermatophagoid mites (review of the literature)].

PMID- 1025467
TI  - [Critical analysis of the data on intra-tissue localization of Lamblia].

PMID- 1025468
TI  - [Case of human tominxosis].

PMID- 1025469
TI  - [Possibility of use of a jet injector for experimental study of local therapy of
      alveococcosis].

PMID- 1025470
TI  - [Detection of Infusoria Tetrahymena stegomyiae (Keilin) in the larvae of Culex
      pipiens molestus and Aedes aegypti].

PMID- 1025471
TI  - [Case of importation of cockroaches Periplaneta sp. into USSR from Sri Lanka].

PMID- 1025472
TI  - Metastatic spread and "escape" from the immune defenses of the host.
AB  - The effectiveness of the host's immune reaction against primary and disseminated
      tumors depends not only on the magnitude of the host's immune response, such as
      the number of cytotoxic cells and antibody molecules produced, but also on the
      capacity of tumor cells to evade destruction. The latter process which has been
      termed "escape" depends on several factors including intrinsic properties of the
      tumor cell. In some experimental systems, it was shown that the capacity of
      disseminated tumor cells to give rise to distant metastases is in part determined
      by the efficiency of escape. Tumors which in vivo appear to be nonimmunogenic may
      still carry tumor-specific antigens to which the host responds by making
      cytotoxic mononuclear cells, but these fail to kill because escape is effective.

PMID- 1025473
TI  - Possible mechanisms in regression.
AB  - The mechanisms responsible for spontaneous regression of cancer may be
      nonimmunologic. Among other possible models, it is suggested that the necrotizing
      properties of endotoxin offer an open approach to the problem.

PMID- 1025474
TI  - Spontaneous regression of colon carcinoma.
AB  - Apparent spontaneous regression of advanced colon carcinoma has been reported in
      7 patients. This is a very rare event, and the circumstances accounting for this
      are elusive.

PMID- 1025475
TI  - Spontaneous regression of cancer evaluated by computerized data.
AB  - Where immunologic intergrity wanes, clinicians observe a greatly increased
      incidence of neoplasia. Factors in this phenomenon are reviewed. With complete
      and detailed recorded data on patients who have exhibited spontaneous regression
      of cancer, a systematic data-reduction approach becomes a practical reality,
      without the inherent handicaps of missing details in patient histories or
      anecdotal and often conjectural observations. Presented here is the plea for
      detailed recording of complete histories of all carcinoma patients who exhibit
      the phenomenon of spontaneous regression. Physicans of several decades ago
      generally considered as unrelated much data deemed important to us today.

PMID- 1025476
TI  - Regression of cancer following surgery.
AB  - Postsurgical tumor regressions are rare but well-recognized entities. The causes
      of such phenomena are unknown but probably are multiple. Regression of any tumor
      must ultimately come about by changes in the host-tumor interaction which
      suddenly becomes unfavorable for tumor growth. This is likely a manifestation of
      changes in the immunocompetence of the host. There are many variables influencing
      the host-tumor interaction, and the study of tumor immunology is stil in its
      infancy. It is through the exploration and investigation of basic mechanisms of
      the immunology of cancer that the most potentially fruitful associations between
      tumor growth or regression and surgical manipulations may be made and applied to
      the treatment of cancer patients.

PMID- 1025477
TI  - [Stereotaxic treatment of extrapyramidal torticollis].

PMID- 1025478
TI  - [Indications and limits of behavioral surgery].

PMID- 1025479
TI  - [Rare anatomical form of spinal cord ependymoma: metastatic ependymoblastoma
      involving whole spinal axis].
AB  - The authors report a case of malignant ependymoma of the terminal medullary cone
      and the cauda equina, presenting at the stage of metastatic diffusion to the
      whole spinal axis. They stress the pathological interest of such a form and its
      extreme rarity.

PMID- 1025480
TI  - [Hyperproduction of CSF in choroid plexus papillomas in children].
AB  - Two cases of papilloma of the choroid plexus in children, one in the fourth
      ventricle and the other in the central part of the left lateral ventricle, are
      reported. Hyperproduction of CSF could be suspected in the first case by the
      productive character of pre-operative external ventricular drainage and
      demonstrated in the second by measurement of pre and post-operative flow rates
      through a ventriculo-peritoneal bypass which had been installed previously. The
      origin of this over-production of CSF is discussed, in the pathogenesis of
      hydrocephalus, in comparison with other factors such as subarachnoid haemorrhage,
      hyperproteinorachia impairing the resorption of CSF.

PMID- 1025481
TI  - [Case report of giant calcified pituitary adenoma].
AB  - The exceptional nature of compact, extensive calcifications in a giant pituitary
      adenoma points to the possibility of immunological, histological and chemical
      mechanisms in the calcification process.

PMID- 1025482
TI  - [Intrasellar colloid cysts].

PMID- 1025483
TI  - Effects of dorsal fornix section and hippocampectomy on adrenocortical responses
      to sensory stimulation in the rat.
AB  - With the purpose of identifying the neural structures which are involved in the
      mediation of the adrenocortical responses to photic, acoustic and sciatic nerve
      stimulation, experiments were conducted on male rats with bilateral section of
      the dorsal fornix and dorsal or ventral hippocampectomies. The basal
      corticosterone levels in these animals were not significantly different from
      those in controls. Stimulation of the 3 sensory modalities produced normal
      adrenocortical responses in rats with fornix section. The hippocampectomies had
      no effect or only a marginal effect on the response to ether stress and to photic
      and acoustic stimulation; however, the adrenal response to sciatic stimulation
      was very significantly reduced. The data demonstrate the participation of the
      hippocampus in the transmission of somatosensory responses which promote
      adrenocortical activity. The efferent connections of the hippocampus to the
      hypothalamus which are involved in this mechanism are discussed.

PMID- 1025484
TI  - Opiate and endocrine interaction: morphine effects on hypothalamus and pineal
      body.
AB  - Experiments were performed on male Holtzman albino rats. Stainless steel
      semimicroelectrodes 60 micron in diameter were implanted stereotaxically in the
      ventromedial hypothalamus (VMH) and in the pineal body (PB). Six to eight days
      following this operation, the sensory field potentials from freely behaving,
      unrestrained rats were averaged. After a control recording was achieved, animals
      were given injections i.p. with 10,30 or 50 mg/kg of morphine and recordings were
      resumed for 45 min. Naloxone was then administered and recordings were monitored
      during another 45 min period. Three consistent components of the averaged sensory
      evoked potentials were evaluated. In both structures following the two lower
      doses of morphine (10 and 30 mg/kg), increased and decreased response amplitudes
      were observed, while following 50 mg/kg morphine, mainly increased response
      amplitudes were obtained in both structures. With increased doses, the percentage
      of responses was increased. During the 45 min of recording after morphine,
      effects remained consistent. Differences in the percentage and the direction of
      the responses were observed between the VMH and the PB. Naloxone (1 mg/kg)
      reversed the morphine effect in the two structures, both the increased and
      decreased responses. The possible interactions between morphine and endocrine
      function of the two structures are discussed.

PMID- 1025506
TI  - [Effect of complex treatment using potassium orotate on the non-specific
      immunologic reactivity of children with viral hepatitis].

PMID- 1025507
TI  - [Tissue hydrophilia and extracellular fluid volume of viral hepatitis patients
      treated with prednisolone].

PMID- 1025508
TI  - [Treatment of hepatic coma in children with viral hepatitis].

PMID- 1025509
TI  - [Clinical picture of postvaccinal reactions in children vaccinated against
      smallpox by the 2-stage method].

PMID- 1025510
TI  - [Chief results of scientific research concerning the problem of 'age and the
      child's body under normal conditions and in pathology' during the 9th five-year
      plan].

PMID- 1025511
TI  - [Current aspects of the control of viral hepatitis (botkin's disease) in children
      in the UkrSSR].

PMID- 1025512
TI  - [Several indices of tissue respiration and clinical assessment of the kimbarov
      colored precipitate test in late toxemia of pregnancy].

PMID- 1025513
TI  - [Rheovasographic indices of several regional vascular zones toward the end of
      normal pregnancy and in pretoxicosis].

PMID- 1025514
TI  - [State of several liver functions in women during pregnancy, labor and after
      labor following prenatal fetal death].

PMID- 1025515
TI  - [Concentration of serotonin in the blood of rheumatic pregnant women with
      circulatory failure].

PMID- 1025516
TI  - [Infarct of the placenta].

PMID- 1025517
TI  - [Diagnosis and the possibility of surgically treating the syndrome of amenorrhea
      of ovarian origin].

PMID- 1025518
TI  - [Functional state of the pituitary and ovaries of girls with sclerocystic
      degeneration of the ovaries].

PMID- 1025519
TI  - [Age and the dynamics of the rate of development of the female pelvis].

PMID- 1025520
TI  - [Cases of cervical pregnancy].

PMID- 1025521
TI  - [Purulent cyst of an imperfectly descended wolffian duct].

PMID- 1025522
TI  - [HB-antigen positive viral hepatitis in children].

PMID- 1025523
TI  - [Clinical significance of bile acidemia in children with viral hepatitis].

PMID- 1025524
TI  - [The ventricular pressure-volume ratio, an index of left ventricular performance
      in man].
AB  - The left ventricular systolic pressure-volume diagram has been established before
      and after infusion of Nitro-prusside, Angiotensin and over post-extrasystolic
      potentiation on 33 patients, by the simultaneous measure of the aortic pressure
      and the left ventricular volume. In every case left ventricular dp/dt max. and
      (dp/dt/Pt) max. have been measured before and during post-extrasystolic
      potentiation, and in 16 cases after vasomotor therapy. The end-systolic left
      ventricular pressure-volume ratio appears to be independent of loading
      modifications--more than dp/dt max. and (dp/dt/Pt) max.--and on the opposite to
      be a good index of inotropic state alterations.

PMID- 1025525
TI  - [Severe extensive acute pneumopathies. Etiological diagnosis by open chest
      pulmonary biopsy. 3 cases].

PMID- 1025526
TI  - [Lipid metabolism disorders and increased vascular risk due to contraceptive
      steroids].

PMID- 1025527
TI  - [Detection of dislocations and dysplasia of the hip].

PMID- 1025528
TI  - [Lymphocytotoxic antibodies in the serum and synovial fluid of patients with
      rheumatoid arthritis].

PMID- 1025529
TI  - [Relation between monoclonal gammapathies and consanguinity].

PMID- 1025530
TI  - [Prolonged remission after cessation of androgen therapy in a patient with
      Fanconi's hereditary bone marrow aplasia].

PMID- 1025531
TI  - [Beneficial effects of injectable amiodarone on syncope in Prinzmetal's angina].

PMID- 1025532
TI  - [Effects of tetramisole in polymyositis and dermatomyositis].

PMID- 1025533
TI  - [Molar expression of results of biochemical analysis. 1st experience concerning
      its application].

PMID- 1025534
TI  - [Development of a system for rapid and automated transmission of results from a
      medical biology laboratory].

PMID- 1025535
TI  - [Comparative studies on the resistance to chlorination of various biological
      contamination indices in the superficial waters].

PMID- 1025536
TI  - [Behavior of a soil herbicide. III. Influence of prometryne on various phases of
      the nitrogen cycle].

PMID- 1025537
TI  - [Study on the presence of alophylus vibrios in the littoral waters of Romagna].

PMID- 1025538
TI  - [Interactions between synthetic detergents and anaerobic soil microflora].

PMID- 1025539
TI  - [Study on the purification of sewage by using Ecobior].

PMID- 1025540
TI  - [Epidemiology and prevention of non-infective diseases of social significance].

PMID- 1025541
TI  - Toward a scientific humanist health care system.

PMID- 1025542
TI  - Plain film diagnoses of medical emergencies.

PMID- 1025543
TI  - Mucopolysaccharide complexes in the fibrous tissue surrounding hydrophilic
      polymers in subcutaneous implantation.
AB  - The biocompatibility of three types of hydrophilic poly-(glycol methacrylate)
      gels--homogeneous, microporous and macroporous--was investigated in an
      experimental subcutaneous implantation. The occurrence of mucopolysaccharide
      complexes formed by both hyaluronic acid and chondroitine sulphates was examined
      in the fibrous tissue which surrounds the implant and penetrates into it in the
      case of a macroporous polymer. In an early stage of investigation hyaluronic acid
      prevails, but with proceeding collagenization the chondroitine sulphate part
      becomes predominant.

PMID- 1025544
TI  - [Direct blood substitution in burn shock].

PMID- 1025545
TI  - [Protein hydrolysates as means of correction of disorders of protien-amino acid
      metabolism in children with chronic enterocolitis].

PMID- 1025546
TI  - [Production of peroxides in the "intralipid" fat emulsion during ultraviolet
      irradiation with addition of blood serum and various therapeutic preparations].

PMID- 1025547
TI  - [Use of colloid plasma substitutes in traumatic shock].

PMID- 1025548
TI  - [Experimental study of anti-anemia preparation - dextrafer].

PMID- 1025549
TI  - [Comparative characteristics of the effect of various blood preservatives on
      myocardial contractility].

PMID- 1025550
TI  - [Study of biological activity of dextran derivatives].

PMID- 1025551
TI  - [Intraosseous method of drug administration and blood transfusion in the
      prevention and treatment of shock and terminal conditions in severely burned
      persons].

PMID- 1025552
TI  - [Method of intraosseous administration of drug solutions, blood and plasma
      substitutes].

PMID- 1025553
TI  - [Determination of molecular weight of plasma substitute, gelatinol solution, by
      the viscosimetric method].

PMID- 1025554
TI  - [Period of availability of the solvents of dried blood preparations and plasma
      substitutes].

PMID- 1025555
TI  - [On the 70th birthday of N.G. Kartashevskii].

PMID- 1025556
TI  - [Prevention and treatment of hemodynamic disorders in subacute hypoplastic anemia
      after splenectomy].

PMID- 1025557
TI  - [Long-term remission of acute leukemia in children with different treatment
      schedules].

PMID- 1025558
TI  - [Characteristics of uric acid metabolism in myelofibrosis].

PMID- 1025559
TI  - [Importance of lymphographic and cavographic data in detection of lesions of the
      retroperitoneal lymph nodes in Hodgkin's disease].

PMID- 1025560
TI  - [Electron-microscopic study of the virus-like structures in the lymph node cells
      in lymphogranulomatosis and lymphocytic leukemia].

PMID- 1025561
TI  - [Paraproteinemia in differential diagnosis of hypoplastic anemia and acute
      leukemia].

PMID- 1025562
TI  - [Excretion of lysozyme in leukemia].

PMID- 1025563
TI  - [Absorption of inorganic iron in polycythemia and anemia].

PMID- 1025564
TI  - [Certain characteristics of morphology and function of the lymphocyte nucleolus
      in healthy persons].

PMID- 1025565
TI  - The effects of anaesthetics and of denervation on rubidium influx and on tissue
      perfusion in rat skeletal muscles, measured by uptake of tritiated water and of
      14C-ethanol.

PMID- 1025566
TI  - Glucose homeostasis during the perinatal period.

PMID- 1025567
TI  - Diabetes mellitus--progress report.

PMID- 1025568
TI  - Blood pressure, edema and proteinuria in pregnancy. 5. Edema relationships.

PMID- 1025569
TI  - Blood pressure, edema and proteinuria in pregnancy. 10. Future study
      considerations.

PMID- 1025570
TI  - Blood pressure, edema and proteinuria in pregnancy. 11. Workshop summation.

PMID- 1025571
TI  - Blood pressure, edema and proteinuria in pregnancy. 2. Epidemiologic aspects.

PMID- 1025572
TI  - Blood pressure, edema and proteinuria in pregnancy. 3. Study design, population
      and data characteristics.
AB  - 1. The mean blood pressure runs a curvilinear pattern during the course of
      pregnancy, with the lowest reading between 20 and 27 weeks of gestation, a
      continuous rise from 28 to 36 weeks, followed by a plateau. 2. the mean blood
      pressure in pregnancies without edema and proteinuria are lowest throughout
      pregnancy. However, the mean blood pressures in pregnancies complicated by edema,
      proteinuria, or both, are less than 5 mm. Hg higher after 28 weeks of gestation.
      3. The mean blood pressures are lower in black gravidas than in white gravidas
      throughout pregnancy, independent of the presence or absence of edema,
      proteinuria, or their combinations. 4. The mean blood pressure is related to age
      and parity. Median-age gravidas (20-34 years) of parity 1-5 have the lowest mean
      blood pressures overall at any time during gestation. The mean blood pressure of
      nulliparas, independent of age, is elevated over the mean blood pressure of
      comparable multiparas. Independent of parity, maternal age systematically affects
      the mean blood pressure. 5. The standard deviations for the mean diastolic and
      systolic blood pressures are approximately 9 and 11 mm. Hg, respectively,
      independent of the weeks of gestation. They are affected very little by the
      absence or presence of edema or proteinuria, or both. 6. Edema of hands and/or
      face occurs more often in black gravidas. 7. The overall perinatal mortality
      rates in pregnancies complicated by edema are not higher than in pregnancies
      without edema.  Perinatal mortality rates in pregnancies with proteinuria, or
      edema and proteinuria, on the other hand, are approximately double the rates for
      pregnancies without edema and proteinuria.

PMID- 1025573
TI  - New approaches to the chemical characterization of membrane molecules.
AB  - Recognition of the H-2D and H-2K cell surface molecules plays an integral role in
      the cell mediated cytolysis of virally infected or chemically modified cells by
      immune cytotoxic thymus derived cells. Previously, technical difficulties have
      made structural studies on these membrane molecules extremely difficult. We
      present micromethods based on detergent solubilization and indirect
      immunoprecipitation which have allowed us to determine the amino acid sequence of
      the N-terminal portion of four H-2D and H-2K molecules. Application of these
      microsequencing methods to the determination of the detailed structure of these
      molecules will allow us to assess their involvement as targets in immune
      surveillance. This kind of approach will facilitate detailed chemical analysis of
      a variety of membrane molecules of interest in developmental and tumor biology.

PMID- 1025574
TI  - Modulation of cell growth and cell-cell stickiness with succinylated concanavalin
      A.

PMID- 1025575
TI  - Regulation of transport in mammalian cell culture.
AB  - The regulation of amino acid transport has been investigated in Balb/3T3 cells.
      Transport for neutral amino acids in animal tissues is carried out by two
      distinct systems. The transport activity of the A system (alanine preferring) is
      inhibited by high internal of substrate amino acids, a process termed trans
      inhibition. In contrast, the L system transport activity is greatly stimulated by
      high internal levels of substrate, a phenomenon termed trans-stimulation.
      Regulation of amino acid transport in animal cells occurs by a repression
      derepression mechanism or by a feedback inhibition or feedback stimulation
      process. The level of endogenous amino acids is shown to be important in the
      regulation of transport activity. Cells which are slow growing or quiescent have
      increased levels of endogenous amino acids, which in turn effect the transport
      activity. The A system transport activity is decreased in quiescent cells,
      whereas L system transport activity increases. Conditions which effect endogenous
      amino acid levels have an effect on transport activity. Feedback regulation of
      transport activity through the amino acid pool levels is another way animal cells
      can regulate transport activity.

PMID- 1025576
TI  - [Pneumonias due to mycoplasma pneumoniae (author's transl)].

PMID- 1025577
TI  - [A contribution to the recognition of the epidemiology of silicotuberculosis in
      metal mines of Yugoslavia (author's transl)].

PMID- 1025578
TI  - [Plasma cell granuloma of the lung (author's transl)].

PMID- 1025579
TI  - [Idiopathic fibrous mediastinitis--a case report (author's transl)].

PMID- 1025580
TI  - [Cytologic diagnosis of giant cell carcinoma of the lung (author's transl)].

PMID- 1025581
TI  - [The Kveim test and its practical significance (author's transl)].

PMID- 1025582
TI  - [Tests for the evaluation of cellular immunity to mycobacterium tuberculosis
      (author's transl)].

PMID- 1025583
TI  - [Three years' experience with bronchofiberoscopy and brush biopsy in the
      diagnosis of bronchial carcinoma (author's transl)].

PMID- 1025584
TI  - [Psychological theories on delinquency].
AB  - The authors review the various psychological explanations of delinquency, based
      on a psycholgoical etiological approach, considered within three broad
      categories: 1) Unchanging intrapersonal factors; 2) Changeable intra-personal
      factors, and 3) Interpersonal factors. For each theory, three criteria of
      validity have been used, based on the theory explanatory power in relation to: 1)
      the differential rates of deliquency for various subgroups, and the peaking at
      age 16; 2) the various forms of delinquent behavior, and, 3) the individual
      motivations to delinquency. The implications for prevention, of the different
      theoretical approaches, are also briefly discussed. The interpersonal theories
      appear to offer the most fruitful research and action opportunities. The
      practical implications for primary prevention, particularly at the school level,
      are discussed.

PMID- 1025585
TI  - [Center for the prevention of drug abuse at the Casa Circondariale "S. Vittore"
      in Milan. Case E/2].

PMID- 1025586
TI  - [Determination of renal plasmatic flow by the hematic curve evaluation of PAH
      decrease (author's transl)].
AB  - PAH clearance utilizing the standard technique with blood and urine collection
      was determined in thirty patients affected by various primary or secondary renal
      diseases. Each of these patients, also had a "bolus" infusion of p
      aminohyppurate. "Bolus clearance" was calculated from the disappearance slope of
      their blood concentration. The "bolus clearance" of PAH correlated well with the
      standard technique. However "Bolus PAH clearance" overestimated the standard
      technique. This overestimated (236 ml/min) was significant and defined by a
      regression factor. Reasons are briefly discussed.

PMID- 1025587
TI  - [Study of the realiability of the Limulus amebocyte lysate test for the detection
      of bacteriuria (author's transl)].
AB  - The Limulus amebocyte lysate test has shown a good agreement with the results of
      cultural methods for the detection of gram-negative bacteriuria. In particular
      this test would seem promising in the examination of urine samples where the
      presence of antibacterial substances makes unreliable the results obtained by
      conventional cultural techniques.

PMID- 1025588
TI  - [The effects of staphylococcal alpha toxin on regenerating liver (author's
      transl)].
AB  - The effects of staphylococcal alpha toxin on regenerating liver of partially
      hepatectomized rats are studied. Sixty six rats are used. They are divided into
      three groups of twenty two animals each one. The first group included untreated
      animals, the rats of second and third group are injected with 0,1 UE of
      staphylococcal alpha toxin, respectively soon after hepatectomy (second group)
      and after twenty two hours (third group). As parameters we used: mitotic
      activity, percentage of hepatic regeneration, the contents of liver water and
      proteins. The results are: a low letality in all the animals, a lower mitotic
      activity in all treated animals than in the intact ones, the percentage of
      restoration, the contents of water and proteins are the same in all the animals
      of the three groups. The AA. conclude that staphylococcal alpha toxin has a
      little negative mitotic effect on partially hepatectomized rats liver.

PMID- 1025589
TI  - [Endoscopic and histofunctional study in gastroptosis (author's transl)].
AB  - The AA., after the nosographic, etiopathogenetic and clinical description of the
      "gastroptosic disease", give their findings of a functional and morphologic
      (gastroscopic and histologic) study accomplished over 200 patients with stomac
      tonus and/or stomac position disturbances. This study, confirming the numerous
      anomalies of the gastric-secretory function, especially of the hyposecretory
      and/or hypohydrochloric type, demonstrates the high incidence of the macro- and
      microscopic changes on the gastric mucosa. The AA., on account of the gastric
      morpho-functional changes observed, discuss, finally, the possible pathogenetic
      mechanisms.

PMID- 1025590
TI  - [Venous occlusion "strain gauge" plethysmography in the estimation of the blood
      flow at rest and after ischemia in the limbs (author's transl)].
AB  - The AA. describe venous occlusion "strain gauge" plethysmography with the
      apparatus and the calibration system necessary for the exact measure of the limb
      blood flow at rest and after ischemia.

PMID- 1025591
TI  - [Enzymatic determination of total serum cholesterol by 4-aminophenazone-phenol:
      manual and automatic method (author's transl)].
AB  - A direct method is proposed for total serum cholesterol determination by two
      specific enzymes and a coupled colorimetric reaction according to Trinder. The
      red colored compound is antipyridilquinonimine. The method is simple (serum plus
      reagent), rapid (30 min of incubation) and relatively inexpensive. It is
      perfectly correlated with Roschlau's method and easy to apply to discrete
      automatic methods.

PMID- 1025592
TI  - [Immunological dtermination of at. III (author's transl)].
AB  - We have effectuated immunologically determination of At. III in serum and plasma
      into two groups of patients: 1) constituted of 10 subjects which never take oral
      hormone contraceptives; 2) constituted of 22 subjects who are taking OHC; for
      various time period. The results indicating that a difference exist between serum
      and plasma At. III concentration, ad this difference reaches to 30%. In this
      series of data the At. III levels was normals.

PMID- 1025593
TI  - [Rate meaning of estriol-dosage in the pregnant wife pointing out the phoetus
      development (author's transl)].
AB  - The AA. point out the meaning of the urinary estriol dosage in high risk
      pregnancy. The screening must be frequent and regular, with constant growing
      curve all time along. A sudden fall down of the rate shows a severe malaise of
      the phoetus and proper therapy is badly needed. Extemporary screenings dont
      supply any sufficient knowledge.

PMID- 1025594
TI  - [Determination of CPK isoenzymes by column chromatography (author's transl)].
AB  - The AA. have carried out in patients affected by proved myocardial infarct, by
      other cardiac diseases and by muscular dystrophy  the following enzymes
      determinations: total CPK, total LDH, SGOT, SGPT, HBDH, CPK isoenzymes by column
      chromatography (Mercer's method) and LDH isoenzymes either by column
      chromatography (Mercer's method) and by electrophoretic separation. Some results
      concerning the appearance of the CK-MB isoenzymes during the acute period of the
      myocardial infarction are described.

PMID- 1025595
TI  - [Effect of ionizing radiation on the activity of superoxide dismutase determined
      by the chemoluminescence method].

PMID- 1025596
TI  - [Effect of x-rays in isolated nuclear membranes].

PMID- 1025597
TI  - [Radiosensitivity of photosynthetic systems of agricultural plants].

PMID- 1025598
TI  - [Mechanisms of taurine hyperexcretion following whole-body irradiation].

PMID- 1025599
TI  - [Changes in the quantity and proliferative activity of hematopoietic stem cells
      following long-term external gamma-irradiation].

PMID- 1025600
TI  - [Changes in the kinetics of erythronormoblast proliferation following long-term
      gamma-irradiation].

PMID- 1025601
TI  - [Effect of the yeast polysaccharide mannan on hematopoiesis in intact mice].

PMID- 1025602
TI  - [Influence of lymphocytes on hematopoiesis in the irradiated body].

PMID- 1025603
TI  - [Effect of ionol on the process of post-radiation recovery of small intestine
      enterocytes].

PMID- 1025604
TI  - [Protective effect of pantothenic acid (vitamin B3) in radiation sickness].

PMID- 1025605
TI  - [Assessment of the functional activity of dog testes following chronic gamma
      irradiation for 6 years].

PMID- 1025606
TI  - [Effect of age on late sequelae in rats following exposure to external beta
      radiation].

PMID- 1025607
TI  - [Hemodynamics in dogs following inhalation of polymeric plutonium-239].

PMID- 1025608
TI  - [Combined effect of acceleration and double exposure to radiation in 50 and 100 r
      doses on conditioned reflexes in rats and transfer of experience in a maze].

PMID- 1025609
TI  - [Calculation of the distribution of absorbed energy in the microstructures of
      tissues and organs following internal irradiation with heavily charged
      particles].

PMID- 1025610
TI  - [Effect of ionizing radiation on the processes of ion transport in liver
      mitochondria].

PMID- 1025611
TI  - [Effect of fractionated x-irradiation and also chronic and chronic combined with
      acute gamma-irradiation with Co60 on catecholamine concentration in rat
      myocardium].

PMID- 1025612
TI  - [Changes in the transport of K+ ions through phospholipid membranes during
      peroxidation induced by radiation].

PMID- 1025613
TI  - [Effect of high-polymer heterologous DNA on restoration of colony forming units
      in the hematopoietic tissues of irradiated mice].

PMID- 1025614
TI  - [Erythropoetic activity of the plasma of irradiated animals].

PMID- 1025615
TI  - [Role of tocopheral (vitamin E) in the additionally damaging effect of post
      radiation hyperoxia].

PMID- 1025617
TI  - [State of hematopoiesis in dogs following repeated unequal gamma-irradiation].

PMID- 1025616
TI  - [Myelokaryocyte dynamics during protracted repeated gamma-irradiation].

PMID- 1025618
TI  - [Mechanism of the therapeutic effect of different doses of DNA following
      radiation injuries in rats].

PMID- 1025619
TI  - [Early reactions of mouse skin to a single application of accelerated boron
      ions].

PMID- 1025620
TI  - [Testicular reaction to combined irradiation].

PMID- 1025621
TI  - [Effect of benzene in the irradiated body (concerning the mechanism of its
      radiomimetic effect)].

PMID- 1025622
TI  - Mass-spectrographic evidence of the conversion of p-chloroamphetamine to 3,4
      dimethoxyamphetamine.
AB  - Intraventricularly injected p-chloroamphetamine (p-CA) was actively metabolized
      to 3,4-dimethoxyamphetamine (3,4-DMA) in the rat brain. Time-course experiments
      with intraperitoneally injected p-CA confirmed that the presence of cerebral 3,4
      DMA was not due to its "one-pass" entry from the peripheral organs. The identity
      of 3,4-DMA from brain tissue and urine was established by comparison to authentic
      3,4-DMA. The synthetic and biological samples were isographic in all analytical
      systems. 3,4-DMA from biological samples was verified by mass spectrography.

PMID- 1025623
TI  - Scanning electron microscopy of four teleostean retinas.
AB  - The morphology of the retinas of the goldeye Hiodon alosoides (fam. Hiodontidae),
      the brook trout Salvelinus fontinalis (fam. Salmonidae), the yellow perch Perca
      flavescens and the walleye Stizostedion vitreum (fam. Percidae) was studied by
      SEM. Semi-thin plastic sections of the same retinas were also examined for
      comparison. Contrary to observation of earlier authors the goldeye retina was
      found to possess both rods and cones; in the case of the other three fishes'
      retinas, present observations correspond to previous ones, adding only details.
      SEM gives an impressive, three dimensil view of the gross surface features of the
      retinas. Shrinkage during the processing of the specimens for SEM, while not
      altering the general topography, does induce artifacts in both plexiform layers.

PMID- 1025624
TI  - [Absorption of D(+)glucose by the intestine of the eledone (Eledone moschata
      Lamarch): effect of phloridzoside].
AB  - "The in vivo intestinal absorption of D(+)glucose by Eledone (Eledone moschata
      Lamarck), a cephalopod mollusc, is decreased by 2.10(-4)M phlorizin and increased
      by 2.10(-2)M phlorizin. It is noted that phlorizin is dissolved in the glucose
      solution before its introduction into the intestinal tube. The first result is
      similar to that known in vertebrates; the second differs."

PMID- 1025625
TI  - [Observations in a series of one hundred neurosurgical patients studied with
      computerized axial tomography (author's transl)].

PMID- 1025626
TI  - [Rhinorrhea in primary empty sella (author's transl)].

PMID- 1025627
TI  - [The middle ear muscular reflex and its application in the clinical otoneurology
      (author's transl)].

PMID- 1025628
TI  - [Traumatic aniridia (author's transl)].

PMID- 1025629
TI  - [Ophthalmology in brief notes].

PMID- 1025630
TI  - Domiciliary care facilities under the SSI program in selected states.

PMID- 1025631
TI  - The maximum allowable cost regulations and pharmaceutical research and
      development.

PMID- 1025632
TI  - Factors influencing the release of adult residents in public mental institutions,
      1967.

PMID- 1025633
TI  - The pathology and pathogenesis of Trypanosoma vivax infection in the goat.
AB  - Acute and chronic forms of disease can be distinguished in Trypanosoma vivax
      infection in the goat. The main difference between the acute and chronic form
      seems to be the presence of microthrombi in the acute stage of infection; these
      consist of platelets, trypanosomes, monocytoid cells and some fibrin. This
      thrombus formation seems directly related to the high parasitaemia in acute
      trypanosomiasis and may result in ischaemia which could also explain the
      haemorrhages, the oedema of the lungs and other tissues, and the necrotic changes
      found in several organs. The anaemia, associated with erythrophagocytosis,
      haemosiderosis, extramedullary haemopoiesis and hyperactivity of the bone marrow,
      seemed to be of haemolytic origin. The factors leading to emaciation seemed to be
      degenerative atrophy of muscular tissue and loss of protein in the urine caused
      by a possible immune complex glomerulonephritis.

PMID- 1025634
TI  - Seasonal changes in the coat of the cat.
AB  - The coats of four cats were studied for 20 months through one winter and one
      summer in Australia. It was found that the outer coat and undercoat length varied
      from 25 mm and 12 mm in summer to 30 mm and 15 mm in winter. Follicle activity
      was at a maximum about February (late summer) and at a minimum in August (late
      winter). The peak of winter inactivity was narrow, and fell short of 100 per
      cent. During summer never more than 70 per cent of the outer coat hairs, and 50
      per cent of the undercoat were active, indicating that despite a basic seasonal
      cycle, hair replacement is relatively gradual.

PMID- 1025635
TI  - Babesia major in Britain: cross-immunity trials with Babesia divergens in
      splenectomised calves.
AB  - Splenectomised calves infected with Babesia major were shown to have no
      resistance to challenge with Babesia divergens; however, initial infection with B
      divergens provided a good protection against subsequent challenge with B major.
      It is suggested that this might mean that B divergens would be the dominant and
      most commonly encountered species in areas where both occur.

PMID- 1025636
TI  - Determinative data for 4'-O-methyl equol and related compounds.

PMID- 1025637
TI  - The effects of haemorrhagic anaemia and physical training on the energy
      metabolism and heart rate response to exercise in sheep.
AB  - The energy metabolism and heart rate response to exercise were studied in
      haemorrhagically anaemic sheep. Anaemia did not affect the efficiency of food
      utilisation, but might reduce appetite. Anaemic sheep were at no particular
      circulatory disadvantage under the stress of physical exertion up to the levels
      imposed in this experiment (3-2km/h, 8 degrees -12 degrees gradient), but they
      appeared to undergo some circulatory adaptation, probably an increased stroke
      volume.

PMID- 1025638
TI  - The effect of corticosteroids on the cysticerci of Taenia ovis in sheep.
AB  - The effect of two synthetic corticosteroids on the cysticerci of Taenia ovis in
      sheep has been investigated. Dexamethasone given from four days before infection
      had no effect on the number of cysticerci recovered but did enhance their
      survival. When betamethasone was used there was an increase in the number of
      cysts compared with controls. Corticosteroids given for 12 days after infection
      did not increase the number of viable cysticerci recovered at autopsy three
      months later but when treatment was continued until the time of autopsy, a very
      high proportion of cysticerci were viable.

PMID- 1025639
TI  - Amount of western equine encephalitis virus inoculated by transmitting Culex
      tarsalis mosquitoes.
AB  - The amount of western equine encephalitis virus inoculated by infected Culex
      tarsalis mosquitoes is highly variable between individual mosquitoes. The
      majority (68 per cent) inoculate less than 100 intracerebral three-week-old mouse
      LD50 at time of feeding and the quanity appears unrelated to temperature or
      length of incubation following initial infection.

PMID- 1025640
TI  - The experimental infection of calves with a British leptospire of the Pomona
      serogroup.
AB  - Two calves were infected with a British leptospire of the Pomona serogroup. Both
      showed symptoms of anorexia and fever and one had marked haemoglobinurea and
      leptospiruria. The serum antibody titres rose rapidly in both calves.

PMID- 1025641
TI  - Effects of vasectomy on fructose levels in the ejaculate of rams.
AB  - Fructose concentration was studied in the ejaculates of 20 intact and 19
      vasectomised rams over a two year period. In intact rams the concentration ranged
      from 222-740 mg/100 ml of seminal plasma during the breeding season (October to
      December), with lower values (0-300 mg/100) during the rest of the year. In
      vasectomised rams the seasonal pattern was less marked with very high values (800
      1260 mg/100 ml) as well as low values (0-20 mg/100 ml) being encountered during
      both the breeding and non-breeding seasons, indicating changes in accessory gland
      function.

PMID- 1025642
TI  - Proximal airway conditions-some theoretical considerations.

PMID- 1025643
TI  - Internships for respiratory therapy.

PMID- 1025644
TI  - RT education: role for proprietary schools? Part II.

PMID- 1025645
TI  - [Behavior of zinc and iron in rheumatoid arthritis].

PMID- 1025646
TI  - [Metabolic nutritional aspects and dietetic treatment of rheumatoid arthritis].

PMID- 1025647
TI  - The e antigen and antibody in the serum of patients with HBsAg-positive liver
      disease and in asymptomatic carriers.
AB  - Serum samples from 103 HBsAg positive and 69 negative patients were examined in
      Ouchterlony double diffusion in agarose for the presence of e antigen and anti-e
      antibody. e antigen was found in 66% of the cases of active chronic hepatitis,
      18% of those of active cirrhosis, and 12% of those of acute hepatitis. Anti-e
      antibody was found only in asymptomatic chronic carriers; it occurred in 56% of
      HBsAg-positive individuals with normal livers at biopsy. No e reactivity was
      found in 6 subjects with inactive disease and in 3 with chronic persistent
      hepatitis. The e system seems a valuable diagnostic tool utilizing the presence
      of the antigen to differentiate patients with chronic progressive disease from
      healthy carriers who, in contrast, often have circulating anti-e antibodies; its
      clinical value, however, is at present limited  by the low sensitivity of the
      technique used for antigen detection. A significant association between e antigen
      and the intrahepatic expression of the core determinant of the HB virus was
      observed inthis study, suggesting they have a similar role in pathogenicity and
      infectivity; the association between anti-e antibody and HBsAg appeared
      uncertain, HBsAg being present in the liver irrespective of e reactivity.

PMID- 1025648
TI  - Primary hyperparathyroidism: diagnostic value of a model of multivariate
      statistical analysis.
AB  - In examining a group of 90 hypercalcaemic patients (37 with primary
      hyperparathyroidism), a comparison was made of the diagnostic reliability of: 1)
      tests commonly used for diagnosis of primary hyperparathyroidism; 2)
      radioimmunoassay of plasma parathormone; 3) a recently introduced model of
      multivariate statistical analysis. The results indicate that, at present, the
      model of multivariate statistical analysis used is of higher diagnostic
      reliability in the diagnosis of primary hyperparathyroidism than renal phosphate
      excretion tests and the radioimmunoassay of PTH itself.

PMID- 1025649
TI  - The problem of infections in acute leukemias. Personal experience in diagnosis
      and treatment.
AB  - This report is based on experience over the last 5 years in the diagnosis and
      treatment of infections in 200 acute leukemic patients hospitalized in the
      Institute of Haematology, University of Rome. The relevant clinical and
      laboratory findings are discussed in relation to the diagnosis of secondary
      infections. Most of the febrile episodes were associated with infection. The
      frequently rapid development of the infections in these patients requires
      empirical antibiotic treatment. The best results were obtained when the
      combinations carbenicillin-cephalothin-gentamicin (success rate of 65%), and
      carbenicillin-cephalothin-gentamicin-lyncomycin-methicillin (success rate of
      62%), were used as empirical therapy.

PMID- 1025650
TI  - De Lange syndrome. Clinical, dermatoglyphic and chromosomal findings in nine
      cases.
AB  - Nine cases of the de Lange syndrome are reviewed. Our findings show that the
      facial characteristics in the present series and in previously reported cases are
      remarkably similar. Dermatoglyphically, we have documented an increased incidence
      of tibial loops on the hallucal area and increased incidence of single flexion
      creases of the digits from this study series. Our study also supports the
      previous authors who have recorded an increased incidence in radial loops on the
      second and third digits and increased incidence of simian lines. We have not been
      able to document a consistent chromosomal defect.

PMID- 1025651
TI  - Studies on parathyroid scintiphotography.

PMID- 1025652
TI  - The mode of growth within the jejunal crypts of the rat [proceedings].

PMID- 1025653
TI  - Do leukaemic lymphocytes differ from normal lymphocytes in their ability to
      repair DNA damage [proceedings]?

PMID- 1025654
TI  - DNA turnover in nuclei of cells from higher plants [proceedings].

PMID- 1025655
TI  - Formation and turnover of a new aliquot of nuclear DNA [proceedings].

PMID- 1025656
TI  - [Extrasynthesis of DNA and its inhibition by means of a rifampicin derivative in
      suspension cells of the Phaseolus coccineus embryo [proceedings].

PMID- 1025657
TI  - DNA content of midgut in the stick insect Bacillus rossius [proceedings].

PMID- 1025658
TI  - [Genome dimensions of some species of reptiles [proceedings].

PMID- 1025659
TI  - [On the degree of acid-resistance of DNA (or of DNP) in diploid nuclei of
      Loewenthal's gland of the rat examined at 2 different functional moments
      [proceedings].

PMID- 1025660
TI  - [Existence of 2 different morphofunctional aspects of the Purkinje cells in the
      cerebellum of adult rats [proceedings].

PMID- 1025661
TI  - [Analysis of the kinetics of hydrolysis of the Feulgen reaction in cells with
      different euchromatin and heterochromatin ratios (proceedings)].

PMID- 1025662
TI  - [Nucleohistone-lipid interaction (DNA-F2b-histone-phospholipids) (proceedings)].

PMID- 1025663
TI  - Effect of glucagon on synthesis and turnover of DNA in foetal hepatic nuclei of
      rats (proceedings).

PMID- 1025664
TI  - [Cytochemical data on the tetrahydrofolic dehydrogenase of normal and
      pathological human bone marrow cells (proceedings)].

PMID- 1025665
TI  - Localization of endogenous peroxidase in secretory granules of human parotid and
      submandibular gland. An electron microscope study [proceedings)].

PMID- 1025666
TI  - [Histochemical demonstration of proteoglycans (proceedings)].

PMID- 1025667
TI  - [Ultrastructural analysis of mesenchyma composition during development
      (proceedings)].

PMID- 1025668
TI  - [Synthetic mucolytics in the study of epithelial mucins (proceedings)].

PMID- 1025669
TI  - [Histochemical analysis of mesenchyma composition during development
      (proceedings)].

PMID- 1025670
TI  - [Immuno-histochemical localization of human casein (proceedings)].

PMID- 1025671
TI  - The bursa of Fabricius in birds. Recent histochemical aspects of its
      differentiation towards immunological competence.

PMID- 1025672
TI  - Separation of the hepatocyte weight classes by gradient centrifugation
      [proceedings].

PMID- 1025673
TI  - RNA content of isolated hepatocytes determined by microinterferometry
      [proceedings].

PMID- 1025674
TI  - Effect of adrenalectomy on the hepatocyte dry mass.

PMID- 1025675
TI  - [Methyl green as an indicator of the chemico-physical status of DNA in interphase
      chromatin (proceedings)].

PMID- 1025676
TI  - [Analysis of some critical aspects in cytophotometric determination of nuclear
      DNA (Feulgen positive material) (proceedings)].

PMID- 1025677
TI  - [The histochemical use of acridine derivatives for the study of the composition
      and conformational state of DNA (proceedings)].

PMID- 1025678
TI  - [The electromyographic prognosis of facial paralysis "a frigore". Long-term study
      of 40 cases].

PMID- 1025679
TI  - [Vestibulo-oculomotor reflexes in relation to the level of consciousness. V.
      Changes induced by non-hypnotic psychopharmacological agents in induced nystagmus
      in man].

PMID- 1025680
TI  - [Clinical and electroencephalographic studies of subjects with the West syndrome
      appearing after poliomyelitis vaccination].

PMID- 1025681
TI  - [Use of subnarcotic doses of anesthetic drugs as a method of activation in
      clinical electroencephalography].

PMID- 1025682
TI  - [Validity of the stapedius reflex in the diagnosis of myastenia].

PMID- 1025683
TI  - [Epileptiform foci in subjects with seizures or without seizures. Polygraphic
      study of nocturnal sleep].

PMID- 1025684
TI  - [Prognostic value of early convulsive seizures in traumatic coma].

PMID- 1025685
TI  - [Interaction between epileptic foci of both amygdaloid processes: effects of
      ablation of one of the 2 foci].

PMID- 1025686
TI  - [Episodic lethargy in a case of pinealoma].

PMID- 1025687
TI  - [An application of multivariate analysis for the characterization of elementary
      functional EEG situations].

PMID- 1025688
TI  - [Absence of preventive anti-epileptic action of taurine on experimental
      epileptogenic foci].

PMID- 1025689
TI  - [Reflex epilepsy self-induced by ocular fixation on finely structured surfaces
      (pattern sensitive epilepsy)].

PMID- 1025690
TI  - [Cortico-caudate interactions during the development of epilepsy due to
      experimental neocortical foci].

PMID- 1025691
TI  - [Correlations between the spontaneous activity of pairs of thalamic neuron pairs
      during sleep].

PMID- 1025693
TI  - [Aspects of mental hygiene and work].

PMID- 1025692
TI  - [Preliminary results of study of the behavior of the stapedius reflex in
      dystrophia myotonica].

PMID- 1025694
TI  - [Experience of 5 campaigns of detection of nasopharyngeal carriers of
      Meningococcus (1970-71 to 1974-75) in relation to the last outbreak of
      meningococcal infections, taking place in the Hospital Nacional de Enfermedades
      Infecciosas (Hospital del Rey)].

PMID- 1025695
TI  - [Epidemiological importance of meat products as vehicles of anaerobic bacteria].

PMID- 1025696
TI  - [Health care in natural disasters. An outline of practical guidelines].

PMID- 1025697
TI  - [Chromatid breaks induced by low-dosage radiation in cells of mammals].

PMID- 1025699
TI  - [Vasomotor lymph drainage a peripheral association of vessels].

PMID- 1025698
TI  - [Effect of alarm substance on the heart rate in Phoxinus phoxinus (L.)
      (Cyprinidae, Ostariophysi, Pisces)].

PMID- 1025700
TI  - [Distortion of body axis in young minnows (Phoxinus laevis) following destruction
      of the subcommissural organ].

PMID- 1025701
TI  - [Histology and histochemistry of the neurovascular complex of the bat's wing].

PMID- 1025702
TI  - [Effect of juvenile hormones on the prothoracic glands in Manduca sexta in vivo
      and in vitro].

PMID- 1025703
TI  - [Variation in the size and location of the 2nd premolar in the domestic cat,
      Felis silvestris f. catus].

PMID- 1025704
TI  - [Taxonomic problems in sea- and fresh water trout].

PMID- 1025705
TI  - Mortality and mental health: evidence from the Midtown Manhattan Restudy.

PMID- 1025706
TI  - Avoidance of the ontological confrontation of death and physiological measures in
      a field setting simulating a death atmosphere.

PMID- 1025707
TI  - Behavioral science and medical education: a biobehavioral perspective.

PMID- 1025708
TI  - Transcultural attitudes toward antisocial behavior: the "worst" crimes.

PMID- 1025709
TI  - Change in physician attitudes toward reform in medical education: the results of
      a field experiment.

PMID- 1025710
TI  - Reproductive freedom, coercion and justice. Some ethical aspects of population
      policy and practice.

PMID- 1025711
TI  - Relative importance of variables in determination of practice location: a pilot
      study.

PMID- 1025712
TI  - A suggested framework for the provision of health facilities in Nigeria.

PMID- 1025713
TI  - The effects of policies and programs on reduction of mental hospitalization.

PMID- 1025715
TI  - Some proposed criteria for behavioral scientists working in medical settings.

PMID- 1025714
TI  - Motivation and family planning: incentives and disincentives in the delivery
      system.

PMID- 1025716
TI  - Review of prevalence and distribution of schistosomiasis in Japan.
AB  - There has been a temporary increase in schistosomiasis japonica after World War
      II in each of the known endemic areas, but a national control programme,
      including use of molluscicides, lining irrigation ditches through rice paddies
      with concrete and the reclamation of swampy areas by drainage and filling, begun
      around 1950, drastically reduced the prevalence and distribution of the disease.
      It can be said that these measures together with improvements in agricultural
      techniques, mechanization of farming and also socioeconomic factors such as
      improvements in the living standards of the inhabitants and urbanization have
      brought about a rapid decrease in schistosomiasis in Japan.

PMID- 1025717
TI  - Current status of schistosomiasis in Laos, Thailand and Malaysia.

PMID- 1025718
TI  - Schistosomiasis japonica in China: a brief review.

PMID- 1025719
TI  - Diagnosis of Schistosoma japonicum infections in man: an introduction and brief
      review.

PMID- 1025720
TI  - Techniques in schistosomiasis field surveys.

PMID- 1025721
TI  - Culture of Schistosoma japonicum (Philippine strain) from the cercarial stage and
      the effects of immune rabbit and human sera in vitro: a preliminary report.

PMID- 1025722
TI  - A review of the biology of the Chinese and Formosan strains of Schistoma
      japonicum.

PMID- 1025723
TI  - The maintenance of Philippine and other strains of Schistosoma japonicum in the
      laboratory and the differences among Philippine strains of Oncomelania.

PMID- 1025724
TI  - Laboratory breeding of Oncomelania nosophora in Japan.

PMID- 1025725
TI  - Morphology and taxonomy of the snail intermediate host of the Mekong schistosome.

PMID- 1025726
TI  - Notes on the aquatic ecology of Lithoglyphopsis aperta.

PMID- 1025727
TI  - Population research on Oncomelania quadrasi in Leyte, Philippines.

PMID- 1025728
TI  - Clinical studies on schistosomiasis japonica in the Philippines: a review.

PMID- 1025729
TI  - A clinico-pathologic study of cases with Schistosoma japonicum infection in
      Indonesia.
AB  - Combined clinico-pathological and laboratory examinations were carried out on 52
      S. japonicum infected patients from an endemic area in Central Sulawesi,
      Indonesia. All of these patients exhibited signs and symptoms of chronic hepato
      splenic schistosomiasis. None of the patients showed evidence of liver cirrhosis
      on histopathological examination. However, varying degrees of portal fibrosis
      were exhibited. The correlation between the degree of fibrosis and the clinical
      and laboratory findings were presented and discussed. Based on the results, liver
      biopsy proved to be a vaulable method of diagnosis in this particular type of
      infection. This study provides new information on S. japonicum infection in the
      area and may support a more solid basis for treatment.

PMID- 1025730
TI  - Clinical study of Mekong schistosomiasis at Khong Island, Southern Laos.

PMID- 1025731
TI  - Studies on IgE level among patients with schistosomiasis japonica in Japan.

PMID- 1025732
TI  - Review of schistosomiasis control in the Philippines.

PMID- 1025733
TI  - Programme of schistosomiasis control in Japan.

PMID- 1025734
TI  - Laboratory trials of two new molluscicides, the bark of "gogo" (Entada
      phasholoides) and Polynactin, against Oncomelania snails: a preliminary report.

PMID- 1025735
TI  - Ambilhar in the treatment of Schistosoma japonicum infection and as an egg
      suppressant for mass treatment.
AB  - Ambilhar or niridazole at a dose of 25 mg per kg body weight for 7 days was found
      ineffective against Sl japonicum infection. Longer period of treatment for 10 to
      14 days gave impressive stool negative conversion and egg reduction rates but
      with moderately severe reactions, the most alarming of which was hallucination.
      To minimize toxicity, the daily dose was reduced but given for a longer duration
      so that the total amount of the drug given per kilogram body weight was
      approximately the same as the 25 mg pre kg per day for 10 to 14 days. Of the two
      treatment schedules tried, the 15 mg per kg per day for 24 days was found
      relatively effective. Although the drug with this treatment regimen was well
      tolerated, a drop-out of 50.8% was observed. Ambilhar was therefore tried as an
      egg suppressant. With a 10-day treatment, all patients were again positive after
      6 months. Egg reduction rates during the 6 months stool follow-up ranged from
      69.8 to 93.5%. Further trials using this dose to be repeated every 3 to 6 months
      is contemplated.

PMID- 1025736
TI  - Recommendations for future research work on the control of Schistosoma japonicum
      in East and Southeast Asia.

PMID- 1025737
TI  - Pseudomonas putrefaciens from clinical material.
AB  - Three strains of Pseudomonas putrefaciens were isolated from routine clinical
      specimens at the University Hospital, Kuala Lumpur, Malaysia. Their cultural and
      biochemical characteristic, and antibiotic susceptibilities are presented.
      Characteristics of diagnostic value were stressed. Two isolates appeared to have
      played a pathogenic role in chronic otitis media.

PMID- 1025738
TI  - A study of the microfilarial periodicity at Bireuen, the type locality of Brugia
      malayi.
AB  - A field study was conducted in August 1974 at Bireuen, Indonesia, at the type
      locality of Brugia malayi from where the parasite was first described by
      Lichtenstein (1927) and Brug (1927), in order to determine the pattern of the
      microfilarial periodicity. From the results, it has been demonstrated that both
      the microfilariae of B. malayi as well as those of W. bancrofti in man from
      Bireuen area are the nocturnally periodic form. The microfilaria rates observed
      in the present survey were  much lower than those recorded by Lichtenstein (1927)
      some 50 years ago in the same areas.

PMID- 1025739
TI  - Physiological response to parasitism. I. Changes in carbohydrate reserves of the
      molluscan host.
AB  - A comparison of tissue carbohydrate levels is made between larval trematode
      infected and uninfected snails under three physiological conditions, i.e.,
      unstarved, starved and re-fed. Under all these conditions, infected snails were
      found to be hyperglycaemic compared to uninfected snails. Contrasting behaviour
      of the digestive gland and the foot under these conditions, suggests that some
      inherent mechanism in the foot is activated which enables it to take up an
      additional role of seplenishing carbohydrate lost to the pararites.

PMID- 1025740
TI  - Absence of plague in certain mammals from Java and Kalimantan (Borneo).
AB  - Antibodies against plague were lacking in 237 wild mammal sera from Java and 103
      from Kalimantan. Wild mammal spleens, 114 from Java and 18 from Kalimantan were
      negative for plague bacilli. A variety of mammalian species and areas was
      examined.

PMID- 1025741
TI  - Periplaneta americana (L.) as intermediate host of Moniliformis moniliformis
      (Bremser) in Penang, Malaysia.

PMID- 1025742
TI  - Abnormal haemoglobins and hereditary ovalocytosis in the Ulu Jempul District of
      Kuala Pilah, West Malaysia.
AB  - A survey of abnormal haemoglobins and hereditary ovalocytosis was carried out
      among 629 Malays of Minangkabau descent in the Ulu Jempul District of Kuala
      Pilah, in the state of Negri Sembilan in West Malaysia.. Several abnormal
      haemoglobins were found with the following frequencies: Hb E 5.25%, Hb CoSp
      2.38%, Hb A2 indonesia 0.80%, a fast moving Hb with a Mobility between A and
      Bart's 0.64% and Hb Q 0.16%. Hereditary ovalocytosis was found in 13.2% of these
      people. None of the persons with hereditary ovalocytosis had any evidence of
      haemolysis.

PMID- 1025743
TI  - Trace elements in air, water and food in the Philippines.
AB  - A study was conducted to determine the levels of trace metals like lead, mercury,
      chromium and cadmium in air, water and foods by colorimetric means. It was
      observed that their levels are within normal limit with minor exceptions which
      was mentioned already.

PMID- 1025744
TI  - Official statistics and blindness in Hong Kong.
AB  - WHO designated 1976 as the year for the prevention of blindness and attention is
      drawn to the prevalence rate and causes of blindness in Hong Kong. The former as
      released by WHO is as high as 1392 per 100,000 and the latter tends to suggest
      Vitamin A deficiency is still an important cause here. This article reviews all
      the official statistics on blindness published in Hong Kong over the past twenty
      years and seeks to suggest an appropriate prevalence rate for Hong Kong and
      demonstrate the changing pattern of causes of blindness in Hong Kong. It
      concludes that Hong Kong should adopt a statistical definition and classification
      of blindness accepted internationally and suggests that in the presentation of
      statistics, the misleading factor of present inclusion of past events should be
      avoided.

PMID- 1025745
TI  - Small mammal ectoparasites from Ancol, Jakarta, Indonesia.

PMID- 1025746
TI  - Angiostrongylus malaysiensis in Indonesia.

PMID- 1025747
TI  - The first record of Hunterellus hookeri parasitizing Rhipicephalus sanguineus in
      Indonesia.

PMID- 1025748
TI  - Gnathostoma spinigerum Owen, 1836 (Nematoda: Gnathostomidae) from a civet cat,
      Prionodon linsang Hardwick, with reference to its dietary habits.
AB  - The recovery of six adult Gnathostoma spinigerum Owen, 1936 from a civet cat,
      Prionodon linsang Hardwick, constitutes the second reported record of this
      parasite and the first authenticated case of adult worms found in a wild animal
      from Malaysia. The food habits of the infected P. linsang as an important link in
      the transmission of G. spinigerum in the intermediate and definitive hosts
      together with the probable distribution of this parasite are discussed.

PMID- 1025749
TI  - Parapleurogonius brevicecum gen. et sp. n. (Trematoda: Pronocephalidae) from a
      freshwater turtle in peninsular Malaysia.
AB  - Parapleurogonius brevicecum gen. et sp. n. is described from the freshwater
      turtle, Kachuga trivittata, in Selangor, Malaysia. Parapleurogonius is most
      closely related to Pleurogonius Looss, 1901, but from which it can be
      distinguished by the termination of the ceca at or just overlapping the anterior
      border of the testes and the pretesticular position of the excretory pore.
      Additionally, Parapleurogonius is described from a freshwater turtle, whereas
      Pleurogonius is only known from marine hosts.

PMID- 1025750
TI  - Biology of the snail-killing fly, Sepedon spangleri Beaver (Diptera:
      Sciomyzidae). II. Ability of the larvae to kill snails of medical importance in
      Thailand.
AB  - S. spangleri larvae preferred five species of non-operculate snails; Gyraulus
      convexiusculus Hutton, Segmentina hemisphaerula Benson, Hippeutis umbilicalis
      Benson, Indoplanorbis exustus Larambergue, and Trochobis trochoideus Benson. They
      occasionally consumed the operculate snails: Melanoides tuberculata Muller,
      Lithoglyphopsis aperta, Hubendickia siamensis Brandt, Lacunopis munensis Brandt,
      Tarebia granifera, Lamarch and Viviparus sp. but were innocuous to Bithynia
      laevis Lea.

PMID- 1025751
TI  - A case of human infection with Newcastle disease virus.
AB  - A case of Newcastle disease virus infection in a female laboratory technician is
      reported for the first time in Malaysia. Infection was acquired by droplet
      infection of the eye while grinding infected chicken in the laboratory. The case
      was confirmed by isolation of Newcastle disease virus from an eye swab taken from
      the subject on the first day of clinical signs. A four-fold rise of
      haemagglutination-inhibition titre was shown when sera on the third day of
      infection and 15 days later were compared.

PMID- 1025752
TI  - Observation on biting midge infestations on Mamburao Beach, Mimdoro, Philippines.
AB  - The occurrence of biting midge infestation involving the species Leptoconops
      (Styloconops) spinosifrons Carter 1921 (Diptera, Ceratopogonidae) is reported
      from a beach resort in Mindoro Island, Philippines. The flies are most active
      between 0700 and 0900 hours, and again, between 1600 and 1800 hours; they are
      most abundant in the shoreline and sand beach area.

PMID- 1025753
TI  - SEAMEO-TROPMED Scientific Group Meeting: Malaria in Southeast Asia.

PMID- 1025754
TI  - [Hepatitis B antigen in children with chronic hepatitis and liver cirrhosis].

PMID- 1025755
TI  - [Pre-excitation syndromes: the reciprocating rhythm mechanism and therapy].

PMID- 1025756
TI  - [Genital prolapse and urinary stress incontinence].

PMID- 1025757
TI  - [Labor after cesarean section].

PMID- 1025758
TI  - [Fibroma ovariii--review of a 10-year surgical material].

PMID- 1025759
TI  - [Our experiences in the treatment of mycosis fungoides by radiation therapy].

PMID- 1025760
TI  - [Oral contraceptive agents, pyridoxine and depression].

PMID- 1025761
TI  - [Amino-aciduria and amino-acidemia as a clinical and diagnostic problem in child
      neuropsychiatry].

PMID- 1025762
TI  - [Restrictive respiratory syndrome--report of a case].

PMID- 1025763
TI  - [Carcinoma in situ of the uterine neck and pregnancy].

PMID- 1025764
TI  - [Chronic hepatitis in children - diagnostic and therapeutic problems].

PMID- 1025765
TI  - [Vaginal hysterectomy].

PMID- 1025766
TI  - [Clinically undiagnosed cases of tuberculous meningitis. I. General review,
      statistics and pathology].

PMID- 1025767
TI  - [Lesions of visible mucous membranes during the course of variola. Studies of 118
      patients in the epidemics in the year 1972].

PMID- 1025768
TI  - [Surgical treatment of habitual abortion].

PMID- 1025769
TI  - [Pleuroma malignum].

PMID- 1025770
TI  - [Clinical and hematological characteristics of heterozygote carriers of a new
      pathological hemoglobin alpha series "Hb Serbia"].

PMID- 1025771
TI  - [Results and perspectives of a study on inborn errors of metabolism].

PMID- 1025772
TI  - [Acute renal insufficiency in a child with dehydrogenase-glucose-6-phosphate
      (G6PD) deficiency].

PMID- 1025773
TI  - [Eosinophilic lung infiltration and bronchial asthma - report of a case].

PMID- 1025774
TI  - [Asthma, eosinophilia, hypocomplementemia and vasculitis].

PMID- 1025775
TI  - [Poisoning by orally administered bismuth salts. Epidemiologic survey].

PMID- 1025776
TI  - [Experimental study of bismuth elimination by hemodialysis].

PMID- 1025777
TI  - [Attempt at evaluation of the bismuth fixation capacity of human feces].

PMID- 1025778
TI  - [Bismuth encepalopathies. Clinical observations and results of a method of
      detection of the poison in biologic fluids].

PMID- 1025779
TI  - [Action of levamisole on bone marrow repair in patients undergoing anticancer
      chemotherapy].

PMID- 1025780
TI  - [Comparison of 2 methods of determination of serum INH. (study in 50 patients)].

PMID- 1025781
TI  - [Fatal hyperthermia caused by voluntary poisoning by protizinic acid and acetyl
      salicylic acid].

PMID- 1025782
TI  - [Phlogogenic effects of arachidonic acid].

PMID- 1025783
TI  - Relevance of medical research to patient care.

PMID- 1025784
TI  - [Acquisition and study of callus tissue during cultivation of mazzard and
      strawberry anthers].
AB  - Anters of 7 varieties of Cerasus avium (2n=16) and Fragaria grandiflora (2n==56)
      were cultured on Murashige-Skoog's medium. Formation of the callus tissue was
      observed for only one variety of sweat cherry with a frequency of 3.1-20.6%. The
      number of haploid cells in first transfers varied from 22 to 44% in different
      strains. There were two rises of mitotic activity in the callus cells. Subsequent
      transfers caused an increase in haploid cells. Chromosome aberrations frequency
      was comparatively low. No cases of induced organogenesis on any modifications of
      the nutrient media were found.

PMID- 1025785
TI  - [Relationship between the concentration of protein in the grain of M1 winter
      wheat plants and their depression and frequency of mutations in M2].

PMID- 1025786
TI  - [Gametocide and retardant effect of ethrel on winter wheat plants].

PMID- 1025787
TI  - [Relationship between the frost resistance of hybrid populations of winter wheat
      plants and their original forms].

PMID- 1025788
TI  - [Circadian rhythm of cell division and mitosis duration in the root meristem of
      the common pea under normal conditions and under the influence of thyroxine].
AB  - Daily rhythms of the mitotic activity (MA) and mitosis duration were studied in
      meristem of the Pisum sativum L. primary roots. It is determined that MA
      increases in the day time. The daily rhythm of mitosis duration is absent. The
      germination of Pisum sativum seeds in solution with 1-thyroxine revealed that
      thyroxine increases average diurnal MA and results in formation of two-phases
      rhythm of mitosis number. The additional (night) increase of MA is connected with
      prolongation of mitosis.

PMID- 1025789
TI  - [Study of the alcohol-soluble protein of corn by electrophoresis in PAAG].
AB  - An electrophoretic study of zein in 115 lines of common maize resulted in
      detecting 7 types of spectra. The analysis of opaque-2 sources showed that they
      differ between each other in the number and component composition, similar to the
      norm. The study of isogenic lines revealed that in different genotypes the gene
      opaque-2 behaves unsynonymously: it either does not influence the component
      composition of zein or changes it qualitatively.

PMID- 1025790
TI  - [Experimental allergic encephalomyelitis. Ultrastructural changes in the blood
      brain barrier].

PMID- 1025791
TI  - [Determination of the functional state of cells in a stained radioautograph under
      polarized light].

PMID- 1025792
TI  - [Electron microscopic study of the nuclear membrane of SPEV cells during mitosis.
      II. Reconstruction of the nuclear membrane (anaphase and telophase)].
AB  - Reformation of the nuclear envelope of the PKLV cells starts in the early
      anaphase when numerous contacts between membranous elements and chromosomes
      become visible. The nuclear envelope reforms, first, on the periphery of
      chromosomes and in chromosome's centromeric regions, and later - in the telomeric
      regions. The latest reconstruction of nuclear envelope occurs in spaces where
      microtubules come up close to the "nuclei", The appearance of normal pore
      complexes in the late telophase is preceded by the appearance, in the early and
      middle telophase, of pores with unusual structure.

PMID- 1025793
TI  - [Splitting of phase G1 of the mitotic cycle of guinea pig large intestine crypt
      cells].
AB  - Changes in shape of the second wave of the labeled mitoses curve previously
      observed by Rowinski and Sawicki (1972) for three crypt zones of three different
      parts of guinea-pig ascending colon are explained by the complicated branching
      structure of the G1-phase. This structure is assumed to be the same for different
      crypt zones and for different sections of the intestine. Changes in shape of the
      second wave of the labeled mitoses curve are explained by the changes in
      distribution of proliferating cell stream between the alternative directions at
      the points of branching of the G1-phase, depending on the crypt zone, the
      intestine section, the cell state, and on the state of intestine.

PMID- 1025794
TI  - [Cytochemical features of cortical neurons during the recovery period following
      early visual deprivation].
AB  - It was shown interferometrically that 10 days after the removal of rabbits, that
      had been exposed to early (from the virth till 2.5 month of life) visual
      deprivation, to the ordinary light conditions, a reliable increase in the neuron
      size could be noted in addition to the reliably increased protein content in the
      cytoplasm of the visual cortex neurons. Degrees of the above changes in neurons
      of laminae III, IV and V are not similar, no complete normalization occurring in
      any lamina. A question of the reversibility of changes caused by early visual
      deprivation and of the compensatory capacities of neuron in particular lamina is
      discussed.

PMID- 1025795
TI  - [Study of structural changes in muscle fiber contractile proteins using
      polarization ultraviolet fluorescence microscopy. II. Effect of troponin
      tropomyosin complex on the conformation of F-actin in muscle fibers].

PMID- 1025796
TI  - [Differences in Kupffer cells with regard to their capacity for phagocytosis].

PMID- 1025797
TI  - [Study of the activity of monoamine oxidase in the brain by electron-cytochemical
      methods].

PMID- 1025798
TI  - The proposals are many and varied...but some tough questions remain.

PMID- 1025799
TI  - H.R. 1: model for an effective NHI program.

PMID- 1025800
TI  - A sampling of public opinion.

PMID- 1025801
TI  - Quality assurance: whose responsibility?

PMID- 1025802
TI  - Short-term results of combined radioimmunotherapy in inoperable lung cancer.
AB  - Fifty-three inoperable lung cancer patients were treated with radiotherapy
      combined with immunostimulation with BCG. A good response was obtained in 30
      patients (56%); the results were not significantly different than those obtained
      with a control group of 50 lung cancer patients matched by age, sex and stage of
      the disease (24 out of 50 equals 46%). These short-term results were compared
      with the immunologic "status" of patients evaluated before treatment by the
      parameters monitoring in vivo and in vitro delayed type hypersensitivity. The
      good response to therapy was documented in a higher percentage of patients with
      positive skin tests to recall and standard antigens and with normal values of
      lymphocyte transformation with PHA and Rosette E-forming cells, in comparison
      with patients with low levels of immunocompetence. An impairment of the cell
      mediated immune response was found after combined therapy, presumably due to
      radiotherapy. BCG was not able to restore the patient's immunocompetence, no
      effect on host's immune reactivity was demonstrated. As regards humoral immunity,
      the patients with low levels of IgG before treatment (12/14) showed a good
      response.

PMID- 1025803
TI  - N-acetyl-beta-glucosaminidase of peripheral blood lymphocytes in patients with
      cancer of the larynx.
AB  - In 20 men, age 35 to 55 years, with cancer of the larynx of N-acetyl-beta
      glucosaminidase in peripheral blood lymphocytes was determined cytochemically
      according to Hayashi's method. Numbers of enzyme-positive cells were counted with
      regard to the type of cytochemical reaction (granular, granular-diffuse, or
      diffuse), and to the number of enzyme-positive lysosomal granules within a single
      cell. In comparison to 20 healthy men, age 20 to 30 years, the following changes
      were noted in the patients: 1) the decrease of the total count of enzyme-negative
      lymphocytes; 2) the decrease of the total count of lymphocytes with granular type
      of reaction; 3) the increase of the counts of lymphocytes with granular-diffuse
      and diffuse type of reaction. The authors suggest that these changes could be
      related to the immune reaction of specific tumor antigens.

PMID- 1025804
TI  - Activity and intracellular localization of lysosomal acid phosphatase in
      lymphocytes from patients with Hodgkin's disease, plasma cell myeloma and primary
      polycythemia.
AB  - Using the cytochemical method after Barka and Anderson, activity and localization
      of lysosomal acid phosphatase (AP) was determined in peripheral-blood lymphocytes
      from 20 healthy subjects, 10 patients with Hodgkin's disease (HD), 10 patients
      with plasma cell myeloma (PCM), and 10 patients with primary polycythemia (PP).
      Total count of AP-positive lymphocytes was lowest in the patients with HD.
      Moreover, they showed a significant decrease of the absolute count of lymphocytes
      with well formed and more numerous AP-positive lysosomal granules. Analogous
      alterations in lymphocytes from patients with PCM and those with PP were much
      less significant. The authors discuss the importance of the above-mentioned
      observations for evaluation on a cellular basis of lowered immunity of patients
      with lympho-proliferative and myelo-proliferative disorders, with special regard
      to AP as a T-cell marker.

PMID- 1025805
TI  - [Carcinomatous metatases on the Chiari's network (author's transl)].

PMID- 1025806
TI  - [Activities and results of the prevention of diphtheria in Turkey in the last 18
      years (1957-74)].

PMID- 1025807
TI  - [Report on the vaccination of unvaccinated diphtheria cases with diphtheria serum
      in the last 25 years (1951-1975) and its relation to treated cases].

PMID- 1025808
TI  - [A new culture medium for the isolation of intestinal bacteria].

PMID- 1025809
TI  - [The 1975-1976 influenza season and results of laboratory studies].

PMID- 1025810
TI  - [Statistical data on toxicological analyses between the years 1970-1976].

PMID- 1025811
TI  - [Identification of various organic synthetic dyes in drugs].

PMID- 1025812
TI  - [The importance of tissue culture in the preparation of viral vaccines].

PMID- 1025813
TI  - [Lymphomatoid papulosis with presence of anti-vessel antibodies].

PMID- 1025814
TI  - [Clinical aspects and problems of diagnosis of peritoneal echinococcosis].

PMID- 1025815
TI  - [Cancer in children in Tunisia. Relative incidence of different histologic types.
      Apropos of 582 cases].

PMID- 1025816
TI  - [Rupture of the urethra. Apropos of 20 ruptures of the urethra in men].

PMID- 1025817
TI  - [Late treatment of a fracture of the mandibular condyle by continuous traction on
      a plaster cast].

PMID- 1025818
TI  - [HLA-B and chronic juvenile polyarthritis].

PMID- 1025819
TI  - [Odyssey of the diagnosis of an intrathoracic opacity (development of a
      heteroplastic dysembryoma in the thymic bed)].

PMID- 1025820
TI  - [Electronystagmographic study of various oto-neurologic complaints seen in an ENT
      department].

PMID- 1025821
TI  - [Survey in 3 rural dispensaries in Cap Bon].

PMID- 1025822
TI  - [Problems posed by irradiation of the Tunisian population during x-ray
      examinations].

PMID- 1025823
TI  - [Preliminary evaluation of 49 cases of varus equinus talipes operated on using
      the same technic].

PMID- 1025824
TI  - [Acrokeratoelastoidosis (Costa)].

PMID- 1025825
TI  - [Various causes of female sterility in the Kef region (Tunisia)].

PMID- 1025826
TI  - [Current status of severe or complicated typhoid].

PMID- 1025827
TI  - [Current profile of typhoid fever].

PMID- 1025828
TI  - [Cardiovascular complications of typhoid fever].

PMID- 1025829
TI  - [Value of EMG in neuromuscular diseases seen in an otoneurology department].

PMID- 1025830
TI  - [Urinary bilharziasis (geographic, parasitologic, anatomopathologic studies-
      signs, diagnosis, treatment].

PMID- 1025831
TI  - [Traumatic diaphragmatic hernias in children with thoracic symptomology].

PMID- 1025832
TI  - [Electromotor nucleus of the tembladera (Torpedo marmorata Risso) II. Oval
      nucleus].

PMID- 1025833
TI  - The sacco-cerebellar tract of "Scylliorhynus canicula" L. Preliminary report.

PMID- 1025834
TI  - [How to avoid the distribution errors in the electronic density measurements on
      photographic plates].

PMID- 1025835
TI  - [Cholinergic innervation of the cerebral arteries. Ultrastructural study].

PMID- 1025836
TI  - [Origin of the staphylococci in slaughtered poultry].
AB  - Studied were 382 coagulase-positive and 290 coagullase-negative Staphylococcus
      strains isolated from birds during their post-slaughter handling, from the vats
      for water cooling as well as from the women working on the slaughter-house
      conveyor. Studied were the phage behaviour, fibrinolysine production, the crystal
      violet test and the type of hemolysines. It was established that the coagulase
      positive staphylococci were lysed slightly by the human and the bovine set of
      phages. The main sources of staphylococci of both human and bovine origin
      appeared to be the nasal cavity and the hands of workers. Evisceration proved to
      contribute to the tenfold higher count of staphylococci in the slaughtered birds.
      Most of the investigated strains of Staphilococcus aureus and Staphylococcus
      epidermidis differed from the human and the bovine type and were probably
      staphylococci of avian origin.

PMID- 1025837
TI  - [Resistance of the causative agents of European foulbrood to oxidative
      disinfecting agents].
AB  - Test materials and naturally infected materials from beehives were used to check
      the resistance of the European foulbrood causative agents to the disinfection
      agents vofasteril, performic acid, and iosan and iosan-CCT. It was that Bac.
      alvei spores are destroyed by 1.5 per cent solution of vofasteril for less than
      an hour's time and by 1.62 per cent solution of performic acid and 4 per cent
      iosan--for 4 hours. Bac. paraalvei are still more sensitive: they are destroyed
      by performic acid and iosan for 1--2 hours.. Sodium dodecylsulfate at the rate of
      1 per cent, added to solutions of vofasteril and performic acid, speed up the
      disinfection action up to four times.

PMID- 1025838
TI  - [Study of the effect of some of the vaccination plans applied in Bulgaria against
      Newcastle disease].
AB  - Comparative studies were carried out on the effect of the vaccination of broilers
      against Newcastle disease with La Sota strain through the single application in
      the drinking water on the 21st day and the newly introduced vaccination at the
      age of four days, using the spray method, as well as the combined method--spray
      vaccination on the fourth day and giving the vaccine twice on the 21st day. It
      was found that the last method confers better immunity and higher immunity
      against the disease as compared to offering the vaccine only once on the 21st
      day.

PMID- 1025839
TI  - [Cultivation and study of the properties of the Perego strain of the sheep
      poxvirus on heterologous tissue].
AB  - Strain Perego of the sheep pox virus, after 11 passages in lamb testis cultures,
      was successfully adapted and cultivated in 10 successive passages in a
      heterologous tissue--secondary cultures of newborn calf kidney. The infected
      cultures produced a cytopathic effect similar to that observed in a homologous
      culture, the difference being that part of the degenerated cells came off from
      the wall of the flask. At the level of its 10th passage the virus exhibited a
      titer of 10(3)CPE50. The virus was tested for harmlessness on sheep through a
      subcutaneous inoculation at a dose of 1 cm3 of a 1:10 dilution, and its testing
      for activity (1:100 dilution) caused an easily tolerated local reaction with a
      slight rise in the body temperature, the general status of the test animals
      remaining unaffected.

PMID- 1025840
TI  - [Experimental Q-rickettsiosis in lambs].
AB  - The clinical course, serologic response, and morphologic changes were followed up
      in month-old lambs infected nasally and via the trachea with Rickettsia burneti
      at the rate of 10,000 ID50/cm3. Rickettsiae were found in the parenchymal organs,
      the blood clot, the nasal cavity, the trachea, and the feces of the animals
      killed on the 7th and 21st day of infection. Complement-fixing antibodies were
      established in the infected lambs with the use of the complement-fixation test
      from the 5-6th up to the 160th day (period of testing), the highest value of the
      titer (1:160) being observed on the 32nd day. Demonstrated were changes in the
      vessels, and degeneration was found in the liver, kidneys, and other viscera
      along with proliferative changes in the spleen. Guinea pigs and albino mice were
      successfully made use of to isolate Rickettsia burneti from the infected
      parenchymal organs, feces, and others of affected lambs.

PMID- 1025841
TI  - [Dermatophyte and Candida genus fungal carrier state in piglets].
AB  - Studied were a total of 1200 pigs aged 1, 2, and 3 months, showing no clinical
      symptoms of skin or hair diseases. It was demonstrated that Candida carriers
      accounted for 2.6 per cent among the animals raised under primitive pigsty
      conditions, and for 2.5 per cent of those raised under industrial conditions.
      First of the isolated fungi of this genus ranked Candida krusei, followed by C.
      tropicalis and C. guilliermondi. Of the kerationophil fungi K. ajelloi was
      demonstrated in 0.19 per cent of the pigs kept under both primitive and
      industrial conditions of raising. In those that were raised in primitive pig
      house conditions M. gypseum, M. cookei, and T. terrestre were also found.

PMID- 1025842
TI  - [Correlation between the organoleptic evaluation and the laboratory analysis of
      white brined cheese].
AB  - Satisfactory correlation was found to exist between the organoleptic evaluation
      and the chemical analysis of ewe's and cow's white brine cheese on the basis of
      the taste assessment for "normal acidity", while with the remaining degrees of
      acidity--"slightly acid", and "strongly acid"--no such correlation was
      established. The organoleptic and chemical analysis on the basis of "saltiness"
      degrees of the white brine types of cheese proved to correlate comparatively
      well. It is up to the expert to decide whether the organoleptic evaluation will
      be sufficient in a given case.

PMID- 1025843
TI  - [Experiments to obtain and test vaccines against enzootic pneumonia in swine].
AB  - Five-day-old PPLO broth cultures of two Mycoplasma hyorhinis strains were used 
      to obtain an inactivated vaccine consisting of 75 parts culture, 25 parts
      aluminum hydroxyde and 0.1 per cent formalin, and a live vaccine of 75 parts
      culture and 25 parts aluminum hydroxyde. The inactivated vaccine was tested on a
      total of 320 pregnant pigs and the live one--on 3,150 pigs, aged two-three months
      on a farm with a record of M. hyorhinis infection resulting in an enzootic
      pneumonia. In those of the pigs that were born by the vaccinated sows and were
      later on vaccinated themselves the percent of enzootic penumonia morbidity was
      reduced to 50.

PMID- 1025844
TI  - [Experiments to reproduce Yersinia enterocolitica type 9 infection in guinea
      pigs].

PMID- 1025845
TI  - [11th Congress of the Bulgarian Communist Party and the tasks before Bulgarian
      science].

PMID- 1025846
TI  - [Pathohistological changes in guinea pigs experimentally infected with Yersinia
      enterocolitica serotype 9].
AB  - A total of forty-five guinea pigs were injected subcutaneously with 0.1 cu cm
      carboneum tetracholoratum each and were infected with Yersinia enterocolitica
      serotype 9. Part of the animals (31) were treated at the 24th hour following
      infection with omnopon (a morphine preparation). All infected guinea pigs
      developed an infectious process manifested by dystrophic and inflammatory changes
      in the liver, intestine, spleen, lymph nodes and lungs. Those treated with
      omnopon manifested a more acute infectious process. After the 13--20th day of
      infection the lesions became more weakly expressed. On the 50th day the
      inflammatory reaction was observed in the lymph nodes and spleen only. The
      mortality rate in both groups was about 50 per cent.

PMID- 1025847
TI  - [Study of an immunization plan for broilers via the spray method against
      Newcastle disease using vaccines from the Bl and La Sota strains].
AB  - Studied was the immunization pattern against Newcastle disease in birds with the
      use of a spray method on broilers obtained congenitally from their mothers,
      having antihemagglutinins. All birds on one of the premises ( a total of 14, 000)
      were vaccinated when 5 days old with a liquid vaccine of strain B1 (one fourth
      dose per bird) using the Dutch pulverizing apparatus Flox-10 -- group I. Other
      14,000 birds of another of the premises of the same batch were treated at the
      same age with the same dose via the same route of application of a liquid vaccine
      of the La Sota strain --group II. All birds of the two groups were revaccinated
      in the same way at the age of 25 days with a vaccine of the La Sota strain at the
      rate of a whole dose per bird. The birds were kept under equal conditons of
      feeding and management. It was found that they built immunity which protected
      them fully from Newcastle disease up to the end of the fattening period (2
      months). This was demonstrated by the test for establishing resistance to a
      control infection with a highly virulent strain of the Newcastle disease virus
      (challenge) as well as serologically by the hemagglutination inhibition reaction.
      At the slaughter by the end of the fattening period all period all birds of the
      two groups sshowed almost equal average body weight, however, those of group I
      manifested 0.97 per cent lower mortality rate and lower forage intake per kg
      weight (by 23 g on an average).

PMID- 1025848
TI  - [Animal husbandry, the main direction in the development of agriculture (after
      the decisions of the 11th Congress)].

PMID- 1025849
TI  - [Conformational changes in the membranes of antigenically stimulated
      macrophages].
AB  - The conformation changes taking place in the membrane of antigen-stimulated
      macrophages were followed up by means of serologic methods and agglutination with
      concavalin A. It was found that: 1. Following antigen stimulation the receptors,
      located in the cell membrane, are saturated with a lower amount of concavalin A
      than the receptors of unstimulated macrophages. 2. Antigen stimulation enhances
      the agglutinogenic capacity of macrophages. The conformation changes observed are
      discussed in brief.

PMID- 1025850
TI  - [Lactate dehydrogenase (LDH) and its isoenzymatic activity in the blood serum and
      in the meat of pigs with bronchopenumonia].
AB  - Studied was the activity of lactodehydrogenase (LDH) and its isoenzymes in pigs
      suffering from bronchopneumonia and its relation to the water absorption capacity
      of the meat obtained from them. The total activity of LDH is expressed in
      International Units (IU), it being converted into 1000.0 mg total protein in the
      case of meat. It has been found that in diseased pigs the activity of the serum
      DH rises up to 1380.45 IU from the normal level of 691.25 IU. The activity of
      this enzyme in musculus longissimus dorsi in diseased animals has proved to be
      more than twice as higher (256.35 IU) than that in the control group pigs (117.87
      IU). Considerable rise in the activity of the LDH isoenzymes is found in the meat
      and blood serum samples from the affected pigs. Lower values of the water
      absorption capacity (23.73 per cent) of m. longissimus dorsi have been
      established in the diseased pigs as compared to the normalones (28.88 per cent)
      The results obtained show that the changes in the activity of LDH and its
      isoenzymes in the blood serum and musculature are characteristic of pigs affected
      with bronchopneumonia. These changes are valuable both for diagnostic purpose and
      for the evaluation of meat obtained from such animals.

PMID- 1025851
TI  - [Changes in the activity of serum enzymes, total protein and electrolytes in
      experimental babeiasis in sheep].
AB  - Investigations were carried out on the serum enzymes, total proteins and some
      electrolites (potassium and sodium) in eight spleenectomized sheep experimentally
      infected with Babesia organisms. It was found that babesiasis in sheep was
      accompanied by a considerable rise in the activity of GOT and GPT (from 80JU up
      to 260IU and from 4 IU up to 19 IU). The amount of inorganic phosphorus dropped,
      and that of potassium sodium and alkaline phosphatase showed no changes. It is
      believed that the changes in the activity of GOT, GPT and inorganic phosphorus
      depend on the gravity and the duration of the disease and can be used as a
      criterion in determining the pathologic process.

PMID- 1025852
TI  - [Scientific-organizational basis in the development and activity of the sanatoria
      preventoria at the present-day stage].

PMID- 1025853
TI  - [Urgent problems of scientific organization of the sanatorium- and health-resort
      service to adolescents].

PMID- 1025854
TI  - [Therapeutic use of alternating magnetic field in chronic diseases of the veins
      of the lower limbs].

PMID- 1025855
TI  - [Effectiveness of massage in complex treatment of chronic pneumonia (according to
      the spirometric data)].

PMID- 1025856
TI  - [Changes in orthostatic tolerance during physical training of patients with
      chronic ischemic heart disease].

PMID- 1025857
TI  - [Methods of obtaining information concerning the frequency of cardiac
      contractions at the height of exertion during exercise therapy and dosed
      walking].

PMID- 1025858
TI  - [Walking up and down the staircase of patients with history of myocardial
      infarct].

PMID- 1025859
TI  - [Exercise therapy for the prevention and complex treatment of neck contractures
      after burns in children].

PMID- 1025860
TI  - [Exercise therapy after surgical treatment of uncomplicated compression fractures
      of the infrathoracic and lumbar segments of the spine].

PMID- 1025861
TI  - [Treatment by means of different positions during exacerbation of lumbosacral
      radiculitis].

PMID- 1025862
TI  - [Dynamics of the indicators of bioelectric activity of the muscles in children
      with sequelae of polyradiculoneuritis under the effect of complex health-resort
      treatment].

PMID- 1025863
TI  - [Effect of sanatorium-health-resort treatment with the use of euphyllin and
      adrenaline electrophoresis on cerebral hemodynamics in patients with hypothalamic
      syndrome].

PMID- 1025864
TI  - [Work of the sanatorium-preventorium of the combine "Trekhgornaia Manufaktura"].

PMID- 1025865
TI  - [Effect of helium-neon laser radiation on the bioelectric activity of the sensory
      motor zone of the cerebral cortex of rabbit].

PMID- 1025866
TI  - [Change in hemostasis under the effect of galvanic current].

PMID- 1025867
TI  - [Method of calculation of absorbed radiation doses in radon therapy].

PMID- 1025868
TI  - [Effectiveness of sanatorium-preventorium treatment of discogenic radiculitis].

PMID- 1025869
TI  - [Treatment of discogenic lumbosacral radiculitis by dosed traction in mud-diluted
      bath].

PMID- 1025870
TI  - [Importance of an early beginning of physical rehabilitation of patients with
      uncomplicated myocardial infarct].

PMID- 1025871
TI  - [Complex treatment of hypertension and arteriosclerosis at the Shmakovka health
      resort].

PMID- 1025872
TI  - [Mechanism of the effect of drinking mineral waters].

PMID- 1025873
TI  - [Use of pre-formed physical factors in balneo-fangotherapy].

PMID- 1025874
TI  - [Intensity of incorporation of 2-C14-acetate into the cerebrosides and
      gangliosides of the brain and spinal cord of rabbits in experimental allergic
      encephalomyelitis].
AB  - In rabbits the acute form of experimental allergic encephalomyelitis was caused
      by inoculation of emulsion of homologous myelin from spinal cord with Freund's
      adjuvant. In terminal paralytic period of the disease the animals were
      subcutaneously administered with 2-14C-acetate and a dose 50 micronCi per 100 g
      of body weight 2 hrs before death. From lumbar and stem sections of the central
      nervous system purified fractions of cerebrosides and gangliosides were isolated
      and their specific radioactivity was determined. The intensity of the
      cerebrosides synthesis was found to be distinctly decreased not only in the more
      impaired lumbar region but also in the stem section of the central nervous
      system, where the centers of demyelinization were not observed. The intensity of
      the gangliosides synthesis was also markedly decreased, in spite of that their
      content was not altered in the central nervous system under experimental allergic
      encephalomyelitis.

PMID- 1025875
TI  - [Chugaev's reaction for sterols].
AB  - Spectrophotometric patterns of Chugaev's reaction products of forty sterol
      compounds were studied. The reaction was shown to be used for identification and
      the quantitative determination of some sterols.

PMID- 1025876
TI  - [Characteristics of infrared spectra of adenylic nucleotides].
AB  - Spectral patterns of ATP, ADP and AMP in the infrared region are described. The
      presence of absorption zones typical for the monophosphate was found in 580 cm-1,
      650 cm-1, 680 cm-1 and a double zone at 720--730 cm-1. This enabled to identify
      the substnace in the mixture with other nucleotides with an error about 10%.
      Effect of binding of phosphate groups on the position of the absorption zones of
      NH+4 and OH- at 3000--3600 cm-1 and occurence of the typical for P--O--P
      absorption zone at 910 cm-1 were established.

PMID- 1025877
TI  - [Effect of adaptation to cold and moderate cooling on respiration and oxidative
      phosphorylation in the muscle mitochondria of albino rats].
AB  - In rats, exposed to cooling at 2 degrees within 2 hrs, total gas exchange and the
      respiratory activity of sceletal muscles mitochondria were studied. The adapted
      rats, which were kept at 5-7 degrees within 13-17 days, were compared with
      unadapted animals (kept at 18 degrees). In the group of adapted rats cooling
      caused the increase in the total O2 utilization by 105% with increased free
      oxidation in mitochondria and the distinct decrease in P/O ratio. Cooling of
      unadapted rats was accompanied by the increase in O2 utilization by 85% without
      any marked alteration in P/O ratio in sceletal muscles mitochondria. The body
      temperature was not altered.

PMID- 1025878
TI  - [Mechanism of decrease in noradrenaline content in the myocardium under the
      effect of various industrial poisons].
AB  - Alteration in content of catecholamines, DOPA and the monoaminooxidase activity
      (MAO) were observed in rat myocardium under prolonged administration of cobalt (5
      mg of the metal per 1 kg of body weight). A correlation was observed between the
      decrease in noradrenaline content and the MAO activation. In myocardium content
      of noradrenaline was approximately constant in simultaneous administration of an
      MAO inhibitor nyalamide (20 mg/kg of body weight) and cobalt within 10 days. In
      heart muscle the adrenaline concentration did not depend on the MAO activity;
      content of the amine was increased when the content of noradrenaline decreased
      and the MAO activity increased.

PMID- 1025879
TI  - [Characteristics of lipid composition of erythroid and myeloid cells of the bone
      marrow of rabbits].
AB  - Lipid composition of erythroid and myeloid cells of rabbit bone marrow was
      studied by thin layer chromatography. The myelocaryocytes contained
      phospholipids, free and esterified cholesterol, free fatty acids and
      triglycerides. The main components of the total lipid fraction were phospholipids
      and triglycerides. The ratio of phospholipids was lower and content of
      triglycerides and cholesterol esters was higher in myeloid cells, as compared
      with erythroid cells. Also myeloid components of bone marrow contained 1.8-fold
      more lipids per one cell than the erythroid cells.

PMID- 1025880
TI  - [Results and prospects of studying the pathogenesis of cardiovascular diseases].

PMID- 1025881
TI  - [Lactate dehydrogenase isoenzymatic activity in different parts of the brain and
      in the blood serum of rats from different lines during a convulsive seizure
      caused by the action of a sound stimulus].
AB  - Total lactate dehydrogenase activity and relative activities of LDH-1 and LDH-2
      isozymes were found to be distinctly elevated in the cortex of cerebral
      hemispheres (locomotory region) and in medulla oblongata of audiogenic rats KM
      strain. The increase in the total LDH activity was also observed in blood serum
      of rats KM strain. The increase in the total LDH activity and in LDH-4 and LDH-5
      activities in the brain regions studied was shown in epileptoid convulsions of
      audiogenic origin. These alterations demonstrated the compensatory activation of
      glycolysis in the brain tissue.

PMID- 1025882
TI  - [Action of thermal injury on the half-life time and turnover of cytoplasmic RNA
      in the intact tissues of rats].
AB  - In liver tissue, kidney, spleen and sceletal muscle of intact rats and animals,
      subjected to thermic burns of skin of the IIIa-IIIb degree, half-life and
      turnover of ribosomal and transport RNA were studied. In control animals half
      life of ribosomal RNA was 5.1 days in liver tissue, 6.5 days in kidney, 6.7 days
      in spleen and 12.4 days in sceletal muscle. The same pattern for transport RNA
      was equal to 5.8, 4.7, 6.7, and 5.9 days, respectively. The burning trauma caused
      the alteration in turnover of cytoplasmic RNA; the direction and the intensity of
      the turnover had an organospecifics type and depended upon the period of the
      burning impairment.

PMID- 1025883
TI  - [Study of homocarnosine metabolism in the brain tissue in diseases of the nervous
      system].
AB  - An increase in content of homocarnosine was observed in brain tissue of animals
      under experimental trauma of cranium. In tissue of glial tumors of human brain
      low content of homocarnosine was found as compared with the level of the
      substance in brain tissue. The data obtained suggest that homocarnosine was the
      substance, associated with the functional activity of a nervous cell.

PMID- 1025884
TI  - [3-O-methl-D-glucose transport system in the cells of Acholeplasma laidlawii].
AB  - In cells of Acholeplasma laidlawii a constitutive system of transport of glucose
      derivate 3-O-methyl-D-glucose was found. This derivate penetrated into cells,
      without modification and accumulated in free state. The transport system was of
      enzymatic nature and exhibited sharp substrate specificity. The transport of 3-O
      methyl-D-glucose was an active process and occurred against the concentrated
      gradient.

PMID- 1025885
TI  - [Activity and isoenzymatic makeup of the hexokinase of rapid and slow muscles in
      the rabbit normally and the experimental allergic polyneuritis].
AB  - An activity and isozyme spectrum of hexokinase were studied in rapid
      (gastrocnemius) and slow (soleus) muscles of rabbit in normal state and in
      experimental allergic polyneuritis, caused by administration of myelin from
      peripheric nerves mixed with Freund's stimulator. In normal organism the
      hexokinase activity was shown to be several times higher in soleus muscle than in
      gastrocnemius one. In these muscles the isozyme spectrum of the enzyme was
      markedly differentiated. In gastrocnemius muscle of rabbits with experimental
      allergic polyneuritis the hexokinase activity was distinctly increased due to
      increase in amount of the II type of the enzyme; in soleus muscle the decrease in
      the total activity of the enzyme depended upon the decrease in amount
      ofhexokinase II.

PMID- 1025886
TI  - [Effect of antithrombin III on anticoagulating system function in animals
      intravenously injected with tissue thromboplastin].
AB  - In experiments with rats, antithrombin III (a natural inhibitor of fibrinolysis)
      was shown to decrease the activation of the anticoagulation system either in
      prophylactic administration or during the development of thrombogenesis, caused
      by intravenous administration of tissue thromboplastin. The phenomenon led to the
      maintaining of the more high content of fibrinogen in blood of experimental
      animals, to the shortening of the  thrombin time and to the increase in content
      of alpha2-macroglobulin and alpha1-antitrypsin (in-hibitors of fibrinolysis) as
      compard with control animals, administered with the only thrombolastin. Effect of
      antithrombin III depended on periods of administration of the prearation and on
      injection of tissue thromboplastin.

PMID- 1025887
TI  - [Bile secretion intensity and the chemical makeup of the bile in white rats with
      liver dystrophy in the process of sodium selenite treatment].
AB  - In male rats with acute liver dystrophia, caused by carbon tetracloride, effect
      of sodium slentie (at doses of 1 mg and 10 mg per 100 g of body weight) on the
      bile secretion was studied. The drug normalized rapidly the functions of liver
      tissue, synthesis and excretion of bile acids, bilirubin secretion and excetion
      of cholesterol. Treatment with sodium selenite increased detoxication process in
      the organism, prevented death of the animals.

PMID- 1025888
TI  - [Localization of in vivo administered peroxidase in the cells of Ehrlich
      carcinoma].
AB  - Distribution of peroxidase was studied in structures and soluble fractions of
      cytoplasma and nuclei of washed cells of Erhlich carcinoma, obtained from mice,
      previously administered intraperitoneally with the enzyme. Peroxidase was shown
      to penetrate in all the cell fractions studied; the most specific activity of the
      extraneous enzyme was observed in mitochondria.

PMID- 1025889
TI  - [Role of intracellular proteinases and glycosidases in the degradation of the
      'large glycoprotein' responsible for the neuraminidase and hemagglutinating
      activity of the Newcastle disease virus].
AB  - It was shown that the decrease in neuraminidase and hemagglutinin activities in
      Newcastle disease virus (NDV) infected cells, which was revealed in conditions of
      disturbed protein synthesis, could be significantly diminished by addition of an
      inhibitor or trypsin-like proteinases tosyl-lysil-chloromethyl keton. The same
      effect was caused by D-galactonolactone--inhibitor of some glycosidases. These
      data suggested that the action of intracellular proteinases and glycosidases are
      the cause of degradation of 'large glycoprotein', responsible for neuraminidase
      and hemagglutinin activities in NDV-infected cells.

PMID- 1025890
TI  - Separation of cholesterol and its precursors by a method of column and thin-layer
      chromatography.

PMID- 1025891
TI  - [Content of hexuronic acids, hexoses and tyrosine in the lung tissue in
      experimental pneumoconiosis].
AB  - Content of hydroxyproline, thyrosine, hexuronic acids, hexoses and dry weight of
      lungs were studied in animals with pneumoconiosis, caused by various agents: two
      types of silicosis, induced by crystalline and condensed modifications of silica,
      and anthracosis, caused by anthracite. The data obtained showed that in all the
      types of pneumoconiosis dry weight of defatted lungs was increased with
      simultaneous increase of hydroxyproline content in the tissue. The more
      pronounced alterations were observed in silicosis. In all the types of
      pneumoconiosis within the experimental period content of hexuronic acids was
      higher in impaired animals as compared with control ones; the increase in content
      of hexuronic acids preceded the accumulation of hydroxyproline. Content of
      hexoses and thyrosine was distinctly increased within 2 days, which apparently
      correlated with the processes of exudation. Then it was decreased and at the
      later steps of the impairment amount of hexoses and thyrosine was shown to
      increase with simultaneous accumulation of hydroxyproline. Dynamics of
      accumulation of non-collagen components of connective tissue in lungs depended
      upon the type of a dust to which the animals were exposed.

PMID- 1025892
TI  - [Cell-free system of protein synthesis from rat's cardiac muscle].
AB  - A cell-free system of protein synthesis from rat heart muscle is described. The
      system contained preparations of ribosomes, which were not separated from
      myofibrillar proteins. The conditions for incorporation of 14C-leucine into the
      polyribosomes of the fraction were established and its protein synthetizing
      activity was studied.

PMID- 1025893
TI  - [ATP metabolism under conditions of radiation injury and the ways of its
      modification].
AB  - Content, methylation and an intensity of restoration of phosphoric components of
      ATP were studied in cross-striated muscles, brain and liver tissue of normal
      animals. These patterns were also studied in animals, subjected to irradiation:
      within 3 hrs after X-ray treatment (800 r); with subcutaneous administration of
      prozerine (0.5 mcg/kg) and nicotinic acid (20 microng/) 4 hrs before
      decapitation; and also in animals with vagus, cut off at the level of neck two
      weeks before irradiation. In different experimental conditions the character of
      regularity and interrelation between methylation and phosphorylation of ATP were
      established.

PMID- 1025894
TI  - [Activity of enzymes of pentosephosphate pathway in the erythrocytes, myocardium
      and intercostal muscle of patients with mitral valve stenosis].
AB  - Decrease in activities of glucose-6-phosphate dehydrogenase and transketolase was
      observed in erythrocytes of patients with mitral stenosis. Development of the
      disease was accompanied by a further decrease in the enzymatic activity. The
      activity of the enzymes was increased in myocardium of atrium sinistrum at the IV
      stadium as compared with the III stadium of the disease. The glucose-6-phosphate
      dehydrogenase activity was decreased and the transketolase activity was unaltered
      in intercostal muscle of the patients.

PMID- 1025895
TI  - [Regulation of L-asparaginase biosynthesis in mutants of Bacillus mesentericus
      43A, poorly growing in the presence of aspartic acid].
AB  - Biosynthesis of L-asparaginase (EC 3.5.1.1) was inhibited in the growing culture
      of Bac. mesentericus 43A on addition of L-aspartic acid (20 mM). My treatment
      with methyl nitrosourea (2 mg/ml) mutants were obtained, which grew poorly on
      aspartic acid used as the only source of carbon and nitrogen. The aspartic acid
      did not repress the asparaginase biosynthesis in 8 strains, found between the
      mutants. In six of these mutants the asparaginase biosynthesis was inhibited by
      means of the type of catabolite repression. The data obtained suggest that in
      Bac. mesentericus 43A the asparaginase biosynthesis is controlled more likely by
      two independent mechanisms: 1) specific repression with aspartic acid as an end
      product and 2) catabolite repression.

PMID- 1025896
TI  - [Acetylcholinesterase of erythrocytes in various blood diseases].
AB  - Appearance of low molecular components of acetylcholinesterase from erythrocyte
      membranes was found by gel filtration on Sephadex G-200 and polyacrylamide gel
      disc electrophoresis. Content of these components was distinctly increased within
      ghe acute period of Marchiafava-Micheli disease.

PMID- 1025897
TI  - [Effect of stimulating pharmacological agents on the content of L-cystathionine
      in the rabbit brain tissues].
AB  - Concentration of L-cystathionine was distinctly increased in rabbit brain within
      the period of maximal action of drugs, stimulating the central nervous system
      (phenamine, strychnine corasole). A distinct decrease in content of L
      cystathionine was observed within one hour after the administration of strychnine
      and corasole.

PMID- 1025898
TI  - [Modification of the micromethod of estimation of citric acid in the bone
      tissue].
AB  - A modified method is developed for estimation of citric acid in bone tissue.
      Citrate was isolated from acid bone hydrolysate without a preliminary
      deproteinization; then it was oxidized and converted into pentabromaceton by
      treatment of citric acid with bromine. The content of pentabromaceton was
      estimated by a photometric method. The method was highly sensitive and
      reproductible.

PMID- 1025899
TI  - [Chief trends in the activity of the state sanitation supervisory service in the
      area of nutritional hygiene in light of the resolutions of the 25th Congress of
      the CPSU].

PMID- 1025900
TI  - [Inhibitory effect of parenterally administered dicarboxylic amino acids on
      gastric secretion].
AB  - Tests conducted on dogs established that glutaminic and aspargic acids introduced
      into the blood by the drip method call forth inhibition of the gastric secretion
      stimulated by other amino acids (alanine, glycine, proline). The dicarboxylic
      amino acids inhibit also the reflex phase of the gastric secretion provoked by
      injection of histamine. It is only against the background of a repeated
      introduction of histamine for many hours that they produce a sharply marked
      inhibitory effect. This manifests itself chiefly in dogs with denervated isolated
      pouches, while with intact innervation of gastric glands this effect is very
      poorly pronounced. Introduction of beta-adrenolytic-obsidan is attended by a
      drastic reduction of this effect.

PMID- 1025901
TI  - [Biologic value of the protein component of dairy products used in infant
      nutrition].
AB  - Chemical and biological methods were used in determining the biological value of
      dairy products ("Malyutka", "Malysh", B-rice, kephir and "Bebiron-I") employed in
      the nutrition of infants kept on artificial feeding. The results of these methods
      are found to accord well with each other. The highest biological value were found
      to possess the new Soviet-made substituents o

PMID- 1025902
TI  - [Beta-galactosidase deficiency in the small intestine and its enzyme therapy].

PMID- 1025903
TI  - [Hygienic support of parameters of the technological process of producing new
      canned children's and dietetic food].
AB  - Some technological methods employed in the production of new canned foods
      prepared with chicken meat and intended for 5-7 month old infants were
      investigated. Biological experiments established the limits for the thermal
      optimum of sterilization within the range of 125-130 degrees for the new canned
      goods of the type "Kroshka". Furthermore, the most marked loss of the proteinic
      value of the canned goods with the use of modified starches--the jellyfying
      potato and the corn phosphatethan by employing native starches as a structural
      stabilizer, was ascertained. The need for hygienic evaluation of the
      technological methods in developing new baby and dietic foods is stressed.

PMID- 1025904
TI  - [Analysis of iron supply to the bodies of women skiers].
AB  - Observations made in 46 sportswomen-skiers and 16 women not engaged in sporting
      activities demonstrated that in the former the blood plasma iron content declines
      in the spring-summer and rises in the autumn-winter periods, with the greatest
      abundance of iron in food rations being noted in winter, and the lowest--in
      summer. From among food products in the Yaroslavl region most rich in iron are
      meat and bakery ones, while dairy products contain little of this elements. A
      regular intake of the iron-containing preparation ferrocal in amounts of 0.64 g,
      thrice a day had a positive effect of the iron metabolism of the organism, this
      manifesting itself in an appreciable absorption of the element, an increased
      concentration of plasmatic iron, in the improvement of the morphological
      composition of the red blood, of the serum protein fractions and of the general
      condition of the sportswomen with simultaneously increased performance capacity.

PMID- 1025906
TI  - [Calculation of the energy value of a population's food].

PMID- 1025905
TI  - [Influence of vegetables on the glycogen-forming and detoxifying function of the
      liver in chronic mercury poisoning].

PMID- 1025907
TI  - [Effect of refrigeration and methods of treatment with heat on the muscle and
      adipose tissue lipids of ducks].

PMID- 1025908
TI  - [Concentration of ascorbic acid in wild edible plants of the Komi-Permiak
      National Okrug].

PMID- 1025909
TI  - [Teratogenic properties of freshly isolated strains of rubella virus in
      experiments on animals].
AB  - Teratogenic properties of rubella virus circulating in the Soviet Union were
      studied in animal experiments. After inoculation of the virus to white rats on
      the 5th day of pregnancy, an increased number of resorptions, a decrease in the
      number and weight of the embryos were observed. In some rats hydramnion was
      observed. The newborn rats of the infected mothers showed a higher lethality and
      some delay in weight gain as compared to the control animals, as well as
      hydrocephaly and microcephaly (2.2%). Persistence of rubella virus
      hemagglutination-inhibiting antibody in many infected rats and their progeny was
      established. The results indicate that the national s-rains of rubella virus
      affect the course of pregnancy and development of progeny in white rats.

PMID- 1025910
TI  - [Effect of adamantan derivatives on reproduction of influenza A virus in tissue
      culture and in animals].

PMID- 1025911
TI  - [Detection of components of type D oncornavirus in the mitochondria of HEp-2
      cells].
AB  - The HEp-2 cell mitochondria were found to harbor electronoptically dense subvirus
      particles with a byouant density of 1.27-1.28 g/cm3 which formed in the
      mitochondria de novo (experiments on incubation of isolated mitochondria with
      32P). The intramitochondrial localization of proteins of oncornavirus type D was
      proven by different methods of the antigenic analysis (CFT, immune precipitation,
      autoradiography). The additional evidence of the participation of mitochondria in
      biosynthesis of this virus was obtained by the use of inhibitory tests (a
      different effect of chloramphenicol and cycloheximide). The possible role of
      mitochondria in biosynthesis of oncornaviruses is discussed.

PMID- 1025912
TI  - [Manifestation of polylysogeny in Pseudomonas vignae].
AB  - Ultraviolet irradiation and treatment with mitomycin C demonstrated that a
      culture of Ps. vignae, strain 1025, was polylysogenic, as electron microscopic
      preparations of phagolysates revealed two types of virus particles: "large" with
      a hexagonal head of 700 A in diameter, and "small" with a round head of 500 A in
      diameter. Subcultivation of the test and indicator cultures showed in both cases
      formation of particles of these phages, the content of "small" virions increasing
      with the number of passages of negative colonies. Attempts to separate these
      viruses biological methods were not successfull. The phenomenon of polylysogeny
      is unusual in that moderate phage adsorbed repeatedly on host bacteria culture
      and lysed it. The causes of the discovered phenomenon are discussed.

PMID- 1025913
TI  - [Rapid method of titrating interferon].

PMID- 1025915
TI  - [Transforming genes of oncornaviruses].

PMID- 1025914
TI  - [Strategy of persistence (facts, hypotheses)].
AB  - The universal phenomenon of virus persistence is considered to be a regular
      phenomenon primarily meeting the interests of the host. Examinations of 1112
      patients with various diseases of the nervous system revealed a certain
      dependence of macroglobulin measles antibody upon the character of the disease
      and the intensity of demyelinization process. These data do not suggest the
      etiological role of the persisting measles virus in the genesis of multiple
      sclerosis and a large group of other nervous system diseases (SSPE). Similar
      results were obtained in analogous examinations of patients for macroglobulin
      mumps antibody. The results indicate the role of persisting viruses in the
      formation of solid specific immunity as well as their importance for nonspecific
      protection against other immunologically similar diseases. Virus persistence is
      considered to be a certain antiviral strategy of the body based on accumulation
      in the life course of a considerable number of persisting viruses on which both
      specific and nonspecific antiviral protection is founded. Congenital or acquired
      defects of immunity cause the development of the persisting infection and
      appearance of some chronic diseases of the nervous system.

PMID- 1025916
TI  - Experiences of a pelvic teaching group.

PMID- 1025917
TI  - A perspective on health care and women in the Mississippi delta.

PMID- 1025918
TI  - Focus: Women's Health-Federal Commitment.

PMID- 1025919
TI  - Woman workers and job health hazards.

PMID- 1025920
TI  - Commentary: continuing the discussion of women and national health insurance.

PMID- 1025921
TI  - The Dalkon Shield litigation.

PMID- 1025922
TI  - The incidences of thyroid autoimmunity in diabetics and in patients with insulin
      autoimmunity.

PMID- 1025923
TI  - ABO grouping of blood stains by rapid mixed agglutination without first washing.

PMID- 1025924
TI  - X/X translocation in a girl with gonadal dysgenesis.

PMID- 1025925
TI  - Clinical studies on 56 cases of oral malignant tumor.

PMID- 1025926
TI  - An autopsy case of myocardial sarcoidosis.

PMID- 1025927
TI  - Clinical and serological observations of streptococcal infection.

PMID- 1025928
TI  - Electron microscopic studies on retinal capillaries in human diabetic
      retinopathy.

PMID- 1025929
TI  - A scanning electron microscopic study on implantation of Ehrlich ascites tumor
      cells in the peritoneal layer.

PMID- 1025930
TI  - Studies on RNA turnover in rat tissues.

PMID- 1025931
TI  - Evidence for soluble estradiol receptors in the amygdala of male and female rats.

PMID- 1025932
TI  - An autopsy case of mucinous cystadenocarcinoma of the liver.

PMID- 1025933
TI  - Complement fixation to pleuropneumonia-like organism and cold hemagglutination
      titers in children with primary atypical pneumonia.

PMID- 1025934
TI  - Comparative observation on surface topography of teguments and eggshells of
      diphyllobothriid cestodes by scanning electron microscopy.

PMID- 1025935
TI  - Thermal sensibility of the receptor in the knee joint.

PMID- 1025936
TI  - [Psychotropic substances in hysteria].

PMID- 1025937
TI  - The effects of electrical acupuncture on human somatosensory evoked potentials
      and spontaneous brain waves.

PMID- 1025938
TI  - [Verbal conditioning - analysis of a paradigm].
AB  - In this paper relevant empirical studies of verbal conditioning have been
      analysed - one of the first examples of the behavior theory of Skinner applied to
      behavior therapy. Next the verbal conditioning paradigm has been critically
      evaluated as to: - the formation of a theory, - its consequences to the use of
      psychological procedures, also in regard to the significance of verbal
      conditioning in therapy. In conclusion we outlined the advantage of a research
      strategy that with the aid of categorical observation techniques determines and
      predicts the transition frequency of verbalizations of the patients as a function
      of the therapists verbalizations.

PMID- 1025939
TI  - [Narcissus - anthropological psychopathology of a communication disorder].
AB  - In an anthropological-phenomenological interpretation the authors demonstrate the
      multitude of determinants that constitute the myth of Narciss: the connection of
      rejection by the nymph "Echo", the further relation of rejection, suffering and
      the development of reflection, the relation between reflection - thinking - and
      death, that forms the nucleus of the myth.

PMID- 1025940
TI  - [Scientific and organizational tasks in solving the problems involved in the
      chemotherapy of viral infections].

PMID- 1025941
TI  - [Analysis of the function and state of the cardiovascular system in an experiment
      using a mathematical model].

PMID- 1025942
TI  - [Tasks of Soviet public health in executing the resolutions of the 25th Congress
      of the CPSU].

PMID- 1025943
TI  - [Comparative morphology and pathogenesis of lesions of the gastrointestinal tract
      in acute intestinal infections--shigellosis and salmonellosis].

PMID- 1025944
TI  - [Morphologic changes in the central nervous system in amyotrophic lateral
      sclerosis].

PMID- 1025945
TI  - [Development of medical science in the Ukrainian SSR].

PMID- 1025946
TI  - [Development of medical science and practical application of its results during
      the 10th five-year-plan in light of the resolutions of the 25th Congress of the
      CPSU].

PMID- 1025947
TI  - [Condition and tasks of medical science in the Latvian SSR].

PMID- 1025948
TI  - [Present state and prospects for the development of research in the area of
      control of cardiovascular diseases].

PMID- 1025949
TI  - [Current state of endocrinology and chief trends in the elaboration of the
      scientific basis for effective methods of control of endocrine diseases].

PMID- 1025950
TI  - [Physiology of the human brain and prospects for its clinical application].

PMID- 1025951
TI  - [Research in the area of neuropathology and psychiatry and measures for
      increasing its effectiveness].

PMID- 1025952
TI  - [Virus diseases and ways of increasing the effectiveness of their control].

PMID- 1025953
TI  - [Immunologic aspects of resolving the problem of influenza control].

PMID- 1025954
TI  - [Current tasks in the study of allergic diseases].

PMID- 1025955
TI  - [Current state and prospects for theoretical research in hygiene].

PMID- 1025956
TI  - [Methodological aspects of pre-pathological conditions].

PMID- 1025957
TI  - [Adaptive changes in the body in health and disease (methodological analysis)].

PMID- 1025958
TI  - [Methodological problems of human ecology].

PMID- 1025959
TI  - [Certain methodological problems of analysis of human personality].

PMID- 1025960
TI  - [Problem of theory in medicine].

PMID- 1025961
TI  - [Criteria of the present-day scientific topics in medicine].

PMID- 1025963
TI  - The national center for health education in the US: a role of major significance.

PMID- 1025962
TI  - [Problem of reactive determination in the theory of disease].

PMID- 1025964
TI  - An exciting prospect.

PMID- 1025965
TI  - [Communication in primary medical practice--an introduction to selected
      theoretical approaches].

PMID- 1025966
TI  - Birth of the first centre for professional preparation in health education in
      Africa.

PMID- 1025967
TI  - [Transfusion service - synthesis of obligatory arrangements and methodic
      directions].

PMID- 1025968
TI  - [Treatment of arrhythmias in myocardial infarct].

PMID- 1025969
TI  - [Changes of thermoregulation after intravenous or intraventricular administration
      of noradrenaline].

PMID- 1025970
TI  - [Certain problems of clinical course, diagnosis and treatment of perforative
      appendicitis].

PMID- 1025971
TI  - [Glycogen metabolism in the liver of albino rats after removal of the solar
      plexus].

PMID- 1025972
TI  - [Activity of alkaline phosphatase of the bone marrow cells and peripheral blood
      in splenectomized rabbits and dogs after removal of the vermis cerebelli].

PMID- 1025973
TI  - [Efferent connections between the posterior ectosylvian gyrus (field Ep),
      subcortical nodes and midbrain].

PMID- 1025974
TI  - [Morphological, biochemical and serological comparisons in experimental allergic
      encephalitis].

PMID- 1025975
TI  - [Immunologic shifts in the body of albino rats under the effect of chloroprene].

PMID- 1025976
TI  - [Anticonvulsive activity of ethpenal].

PMID- 1025977
TI  - [Creatine kinase of the peritoneal macrophages: isolation, its connection with
      the functional activity of the cells and certain properties].

PMID- 1025978
TI  - [Changes in the activity of various enzymes of Krebs cycle under the effect of
      peroxidized unsaturated fatty acids].

PMID- 1025979
TI  - [Effect of vitamin E on the activity of various liver enzymes and the role of
      lipid peroxides in the pathogenesis of viral hepatitis].

PMID- 1025980
TI  - [New glue compounds on the base of polyvinylbutyral and other polymers].

PMID- 1025981
TI  - [Diagnosis of benign lung tumors].

PMID- 1025982
TI  - [Stabilization of the lower limb in total paralysis of all muscle groups of the
      leg and the gluteal region after poliomyelitis].

PMID- 1025983
TI  - Carbohydrates from hydrocarbons. II. Free and bound sugars from yeast cells grown
      on n-hexadecane.
AB  - Candida lipolytica (strain 10) was grown on an n-hexadecane medium with and
      without yeast extract. The harvested dry cells were weighed at various stages of
      growth. The free sugars from the cultures were obtained by Soxhlet extraction
      with 85% ethyl alcohol. Further qualitative and quantitative analyses of free
      monosaccharides in the concentrated alcoholic extracts were made by paper
      chromatography. Glucose was the only free monosaccharide that could be identified
      at various stages of growth. The chromatographic analysis of the acid-hydrolyzed
      yeast cells indicated the presence of glucose and mannose as dominant bound
      sugars; galactose and xylose were present in minor quantities. In the harvested
      dry cells from the yeast extract-containing medium, in general, greater amounts
      of bound sugars were present.

PMID- 1025984
TI  - Formation of root hairs by the wheat Triticum Vulgare Host. Trichoblasts.
AB  - The process of root hair formation has been studied by light-, transmission-and
      scanning electron microscopy. In the course of root hair development a break of
      the outer cell wall is observed by electron microscopy. It apparently occurs
      after the break of the fibrillar layer. The break of the outer layer of the cell
      wall is assumed to represent the break of the outer mucilage, the cuticle and the
      adjoining amorphous matrix with irregularly oriented cellulose microfibrils. The
      scheme of successive ultrastructural changes in the outer cell wall pattern
      during root hair formation is presented.

PMID- 1025985
TI  - [Fate of operated and conservatively treated coral calculus patients].
AB  - The data of 11 patients with coral calculus have been assessed from various
      aspects. Observations and results are described and conclusions drawn from
      statistical data are discussed with special emphasis on the importance of the
      treatment of calculi.

PMID- 1025986
TI  - [Auto-perfused multi-organ preparations. III. Interpretation of histologic
      changes in perfused organs].
AB  - The functional instability of "multi-organ" preparations has been studied by
      morphological and histochemical assessment of 46 autoperfused heart-lung-kidney
      liver-duodenopancreas preparations. The organs of the autoperfused preparations
      were damaged to different degrees, but the damage was always a function of
      perfusion time (1 to 3 hours). The liver suffered the most serious lesions
      (stagnation, oedema, hepatocytolysis, hydropic degeneration) but lesions such as
      interstitial haemorrhage and oedema though in a milder form appeared also in the 
      kidney. The heart structure was comparatively well preserved.

PMID- 1025987
TI  - Spinal bupivacain anaesthesia in traumatological surgery.
AB  - Two-hundred forty spinal cases of bupivacain anaesthesia are reported. One third
      of the patients was over 60 years of age and one quarter in a poor condition. No
      serious or lasting complications were observed. In the overwhelming majority
      anaesthesia during operation was satisfactory, thus the drug was found suitable
      for use in traumatological surgery. Due to its protracted effect, bupivacain
      ensures analgesia in the early postoperative period.

PMID- 1025989
TI  - [AsoVAC and the scientific societies of the country].

PMID- 1025988
TI  - [Use of cryocoagulation in gynecology].
AB  - Cryocoagulation was performed in 101 cases, mainly when the lesions were on the
      surface of the vaginal portion or when endocervicitis resistant to conservative
      therapy was present. Healing was achieved in 95%, in 65% of the cases in 4 weeks,
      in 32% in 8 weeks. Cryocoagulation is painless and can be applied without
      anaesthesia even in out-patients. It is advisable to apply treatment a few days
      after the end of menstruation. No complications were observed. Pathologic lesions
      or extensive ruptures of the cervix are not suited for cryocoagulation and should
      be treated as before by surgical intervention.

PMID- 1025990
TI  - [The present and future of the postgraduate biomedics in Venezuela].

PMID- 1025991
TI  - [In vitro formation of neuronal circuitries I. Golgi method studies of cerebellar
      rotary cultures (author's transl)].

PMID- 1025992
TI  - [In vitro formation of neuronal circuitries II. Golgi method studies of spinal
      cord rotary cultures].

PMID- 1025993
TI  - [Confinement effect on population and phenotypic characteristics in Aedes aegypti
      (L.)].

PMID- 1025994
TI  - [Larval density and population dynamics of aedes aegypti (L.) in laboratory
      conditions (author's transl)].

PMID- 1025995
TI  - Kinetic and electrophoretic studies on the cyanide insensitive NADH diaphorase of
      human polymorphonuclear leukocytes.

PMID- 1025996
TI  - [Electrophoretic determination of serum proteins of rats infected with
      Trypanosoma venezuelense].

PMID- 1025997
TI  - The Soichet intrauterine device in the treatment of intrauterine adhesions.
AB  - IUD in the shape of a "Y" was inserted following curettage to 32 patients
      suffering from missed abortion or post-partum hemorrhage for the prevention of
      intrauterine adhesion formation, and to 48 patients suffering from sterility as a
      result of intrauterine adhesions. The rate of adhesion formation or recurrence of
      adhesions after their removal by curettage was very low and dropped significantly
      compared to other IUD's.

PMID- 1025998
TI  - Incomplete type I male pseudohermaphroditism.
AB  - The observation of a case of male pseudohermaphroiditism offered the opportunity
      for an analytical review of this pathology. Clinical features and failure to
      respond to prolonged testosterone treatment allowed this case to be included in
      the group characterized by androgen resistance of which a recent classification
      distinguishes various types on the basis of phenotypic and hormonal features.
      Incomplete virilization of the external genitals and high testosterone and LH
      plasma levels were evidence in favour of the conclusion that the case should be
      classified as incomplete male type I pseudohermaphroditism.

PMID- 1025999
TI  - The significance of the combined dexamethasone-HCG test for the assessment of
      hyperandrogenism.
AB  - The combined dexamethasone-HCG test was employed in 57 patients with excessive
      androgen secretion in order to differentiate the Stein-Leventhal syndrome from
      other disorders associated with increased androgen production. The patients were
      classified according to the test results. All except two of the patients gave a
      test result typical for the Stein-Leventhal syndrome.

PMID- 1026000
TI  - First oviduct transplants.
AB  - The first four cases of oviduct transplantation are described. In the first case,
      it consisted in the substitution of an oviduct that could not be recanalized
      after previous sterilization; two further patients had undergone salpingectomy
      for ectopic pregnancy, and one had been salpingectiomized for salpingitis. Donor
      oviducts preserved in liquid nitrogen at--196 degrees C were used as grafts.
      Rejection was prevented by countersensitization according to Theurer, also a
      first instance of the use of this method to be recorded in the literature.

PMID- 1026001
TI  - True pubertas praecox in a girl; onset at nineteen months.
AB  - The authors report a case of true pubertas praecox in a girl with onset at 19
      months; they describe the principal histopathologic, clinical and laboratory
      features and discuss problems of etiopathogenesis and differential diagnosis, as
      well as the prognosis and treatment of this disorder.

PMID- 1026002
TI  - Preparation for surgery in cases of sterility.
AB  - The author illustrates various techniques to be applied in preparation for
      diagnostic and therapeutic procedures for sterility, such as perflation,
      hysterosalpingography, endometrial biopsy, culdoscopy and laparotomy.

PMID- 1026003
TI  - The effect of denervation on carnitine metabolism in rat skeletal muscle.
AB  - We investigated the effect of denervation upon the concentration of carnitine,
      the activity of carnitine palmityltransferase and carnitine acetyltransferase in
      the "red" soleus and "white" extensor digitorum longus muscles of the rat. Soon
      after denervation a marked drop in the amount of muscle carnitine was observed,
      that was more pronounced in the "red" soleus. The activity of both CPT and CAT
      decreased in both types of muscle, but CPT activity decreased to a greater extent
      in the soleus than in the EDL. These data may be indicative of a more impaired
      fat combustion in the "red" than in the "white" muscle following denervation.

PMID- 1026004
TI  - Specificity of trypsin and alpha-chymotrypsin towards neutral substrates.
AB  - Steady state kinetics of the hydrolysis by trypsin and chymotrypsin of the ethyl
      esters of the N-acetyl derivatives of glycine, L-alanine, DL-2-aminobutyric acid,
      L-norvaline, L-valine, L-norleucine and L-leucine were studied at pH 6.6 and 25
      degrees C. It is apparent from the second-order rate constants, kcat/Km, app,
      that there is a significant difference between the specificities of the two
      enzymes toward substrates with a long side chain, such as the derivatives of
      norvaline, norleucine and leucine. The carboxylate ion Asp-189 in the specificity
      pocket of trypsin seems to interfere with the productive binding of substrates
      containing apolar side chains longer than those of the derivatives of DL-2
      aminobutyric acid or L-valine. The basic group of the specific substrates of
      trypsin, such as that of lysine and arginine derivatives, promotes the binding of
      the apolar side chain by neutralizing the negative carboxylate ion of Asp-189.

PMID- 1026005
TI  - Enkephalin analogs with enhanced opiate activity.

PMID- 1026006
TI  - Biological fundamentals of consciousness.

PMID- 1026007
TI  - [Climacteric from a gynecologic point of view].

PMID- 1026008
TI  - [Recording of uterine contraction and frequency of heart rate during labor].

PMID- 1026009
TI  - [Ultrasonic diagnosis of abortion of torpid evolution].

PMID- 1026010
TI  - [Fetotomies. Comments on our experience].

PMID- 1026011
TI  - [Abnormalities of the cephalic pole (3 clinical cases)].

PMID- 1026012
TI  - [Uterine rupture in a 4th month pregnancy (clinical case)].

PMID- 1026013
TI  - [Obstetric anesthesia. Pudendal nerve block].

PMID- 1026014
TI  - [Bening and precancerous pathology of the breast, senography].

PMID- 1026015
TI  - [Infection in obstetrics (postpartum infection)].

PMID- 1026016
TI  - [Methods of therapeutic treatment of postpartum infections].

PMID- 1026017
TI  - [Infection in cesarean section].

PMID- 1026018
TI  - [Hospital infection in puerperal infection].

PMID- 1026019
TI  - [Breast cancer and pregnancy].

PMID- 1026020
TI  - [FSH-LH stimulation test by clomiphene].

PMID- 1026021
TI  - [Treatment of uterine adhesions by curettage and hormonal pseudopregnancy].

PMID- 1026022
TI  - [Complementary clinical methods in malignant breast pathology. Evaluation of the
      cytological diagnosis].

PMID- 1026023
TI  - [Evaluation of the complementaty clinical methods in the diagnosis of benign
      breast lesions].

PMID- 1026024
TI  - [Our criteria on the teaching of obstetrics and gynecology].

PMID- 1026025
TI  - [Epidural anesthesia in obstetrics].

PMID- 1026026
TI  - [Fetal audiometry].

PMID- 1026027
TI  - [Kawai and Cols. vascular index as a measure of placental insufficiency].

PMID- 1026028
TI  - [Relation between the vascular index of Kawai and the morphological evaluation of
      the placenta].

PMID- 1026029
TI  - [Cancer of the endometrium].

PMID- 1026030
TI  - [Gynecologic uterine inversion. (Report of a case)].

PMID- 1026031
TI  - Light and electron microscopic study of an intermediate sertoli-leydig cell tumor
      with a review of literatures in Japan.

PMID- 1026032
TI  - Early detection of pregnancy around the first missed menstrual period by 2 hour
      haemagglutination test.

PMID- 1026033
TI  - LH determination in unconcertrated urine by a haemagglutination test.

PMID- 1026034
TI  - Experimental induction of chorionepithelioma in pregnant rats.

PMID- 1026035
TI  - Studies on histogenesis of experimentally induced chorioepithelioma in rats.

PMID- 1026036
TI  - Influence of androgen on endometrial monoamine oxidase activity of rats.

PMID- 1026037
TI  - Observations of guinea pig syncytiotrophoblast cultured in vitro.

PMID- 1026038
TI  - Effects of progesterone on the growth kinetics and the morphology of a human
      endometrial cancer cell-line.

PMID- 1026039
TI  - Observation of rapid migration of trophoblastic cells from human chorionic villi
      cultured on fixed gelatin film.

PMID- 1026040
TI  - Adjuvant hormone therapy to radiation treatment for cervical cancer.

PMID- 1026041
TI  - Induction of SFD by microspheres blocking of placenta in rats and its influence
      on utero-placental blood flow.

PMID- 1026042
TI  - A study on contraceptive use. Effectiveness of the 75 mcg. ethinyl estradiol
      sequential therapy.

PMID- 1026043
TI  - Statistical analysis of birth-weight and postnatal growth.

PMID- 1026044
TI  - Single umbilical artery --a review of 37 cases--.

PMID- 1026045
TI  - Reinvestigation of crucial cases where first diagnosis by mailing smear test
      disagrees with second diagnosis by cytology and/or biopsy.

PMID- 1026046
TI  - An ultrastructural study of collagen degradation in human involuting uterus.

PMID- 1026047
TI  - Studies of Toxoplasma antibody IGG and 19S IGM by the method of sephadex plate
      gel filtration.

PMID- 1026048
TI  - A kinetic study of carbohydrate metabolism in pregnancy. A glucose turn over
      following one shot intravenous injection.

PMID- 1026049
TI  - Accelerating method for prepared condition of delivery.

PMID- 1026050
TI  - Steroid hormone formation in vitro by human ovarian follicles with different
      structures.

PMID- 1026051
TI  - A case of gonadoblastoma.

PMID- 1026052
TI  - Studies on the formation of experimental small for date (SFD) induced with
      actinomycin D in pregnant rat.

PMID- 1026053
TI  - Studies on the placental functions of experimental SFD in rats.

PMID- 1026054
TI  - Utero-placental blood flow in several abnormal pregnancies of rats studied with
      the microspheres method.

PMID- 1026055
TI  - A multidimensional model of schizophrenia.

PMID- 1026056
TI  - Drugs in the dynamic model on schizophrenia. A literature review.

PMID- 1026057
TI  - [Elements of a theory of psychiatric care].
AB  - According to traditional psychiatric care, hospitalisation is indicated as soon
      as a schizophrenic patient presents an acute episode. If one, on the contrary,
      tries to apply psychiatric crisis intervention in the home of the patient, it
      seems very useful, in order to make people aware of the family's dynamics, to
      observe the psychological transactions related to the medication.

PMID- 1026058
TI  - Effect of the interferon inducer tilorone in inbred CBA mice.
AB  - Tilorone hydrochloride (200 mg/kg) was administered intragastrically to inbred
      CBA mice. After 5, 18 and 48 hr the number of circulating leucocytes and
      peritoneal cells as well as the migration of unstimulated peritoneal cells, the
      blood corticosteroid level and interferon production were investigated. In spite
      of the considerable decrease of the number of mononuclear cells in the blood and
      polynuclear ones in the peritoneal exudate, the drug induced production of
      circulating interferon and stimulated its synthesis by peritoneal cells. The
      blood corticosteroid level and the mast cell count in the peritoneal cavity were
      significantly elevated, but the migration of peritoneal cells in antigen-free
      medium decreased.

PMID- 1026059
TI  - Taxonomy of primycin producing actinomycetes. I. Description of the type strain
      of thermomonospora galeriensis.
AB  - Strain FBUA 1274 (=strain 28/650707, Hungarian National Collection of Medical
      Bacteria, National Institute of Public Health, Budapest) is designated the type
      strain of Thermonospora galeriensis (Valyi-Nagy et al.) comb. nov., and the
      morphological characteristics of this strain are described.

PMID- 1026060
TI  - [Changes in brain levels of taurine and glutamate induced by cortical perfusion
      with taurine].

PMID- 1026061
TI  - [Sensory-motor severity and extension of scintigraphic foci hemispheric lesions].

PMID- 1026062
TI  - [Ultrastructural study on "reactive glia" in phlogosis and neoplasms].

PMID- 1026063
TI  - [Electromyographic examination in the paralytic complications of sciatica
      (apropos of 34 cases)].

PMID- 1026064
TI  - [Memory disorders in Parkinson's disease].

PMID- 1026065
TI  - [A group of patients with neuroses with principally somatic manifestations
      treated with the combination of sulpiride and diazepam].

PMID- 1026066
TI  - [Unusual combination of an olfactory meningioma and a carotid-ophthalmic
      aneurysm].

PMID- 1026067
TI  - [A useful procedure in the treatment of vesico-vaginal fistula by transvesical
      approach].

PMID- 1026068
TI  - [Ectopic implantation of the ureter in the vagina; ectopia and hypoplasia of the
      corresponding kidney].

PMID- 1026069
TI  - [60 cases of recurrent urinary infections: value of partial nephrectomy and
      prolonged administration of trimethoprim-sulfamethoxazole].

PMID- 1026070
TI  - [Giant hydrocalyx].

PMID- 1026071
TI  - [Treatment of prostatic cancer with progestational agents].

PMID- 1026073
TI  - [Burch's operation in the treatment of orthostatic incontinence in women].

PMID- 1026072
TI  - [Unexpected complication of a silicone ureteral prosthesis].

PMID- 1026074
TI  - [Cystic ureteritis and cancer of the urinary tract].

PMID- 1026075
TI  - [Testicular tumors. Personal experience].

PMID- 1026076
TI  - [Testicular dysembryomas and lymph node curettage].

PMID- 1026077
TI  - [A rare and peculiar testicular tumor: leydigioma].

PMID- 1026078
TI  - [Pitfalls in the diagnosis of testicular tumors. Apropos of 5 cases].

PMID- 1026079
TI  - [Testicular tumors. Personal experience].

PMID- 1026080
TI  - Hospital cost inflation and physician payment.

PMID- 1026081
TI  - Practicum-internship. I: Development, implementation and student participation.

PMID- 1026082
TI  - Practicum-internship. II: Interim evaluations.

PMID- 1026083
TI  - Pharmacy internship in Minnesota: outgrowth of an extensive evaluation program.

PMID- 1026085
TI  - The incorporation of basic life-support training in the pharmacy curriculum.

PMID- 1026084
TI  - Improving the quality of the pharmacist as a drug advisor to patients and
      physicians through continuing education.

PMID- 1026086
TI  - A self-instructional law course--teaching by learning objectives.

PMID- 1026087
TI  - Pharmacy education in an Area Health Education System.

PMID- 1026088
TI  - The interface of public administration and pharmacy administration.

PMID- 1026089
TI  - Monitoring patient drug profiles and the legal liability of the pharmacist.

PMID- 1026090
TI  - Issue identification approach to pharmacy education planning. I: overview of some
      major issues.

PMID- 1026091
TI  - Physician-pharmacist and medical malpractice.

PMID- 1026092
TI  - Pharmacist-patient communication: its effect on pharmacy's image.

PMID- 1026093
TI  - Square drawing test. Anew quantitative ataxia test.

PMID- 1026094
TI  - Stabilography as a diagnostic tool in child neurology.

PMID- 1026095
TI  - Electrogravitiograph of crippled children.

PMID- 1026096
TI  - Some results of the application of the stabilograph in the orthopaedic clinic. A
      preliminary report.

PMID- 1026098
TI  - System of human equilibrium control.

PMID- 1026097
TI  - Equilibrial approach to scoliotic posture.

PMID- 1026099
TI  - [New mathematical model of genetic code with passive resistance to mutations or
      buccion and complementary dynamic protective mechanisms against noise at genome
      level].

PMID- 1026100
TI  - Action of liver on the in vitro brain cortex resporatory process. A
      neurometabolic hepatic factor.

PMID- 1026101
TI  - [Olfactory bulb and drinking behavior].

PMID- 1026102
TI  - Further investigations on the function of juxtamedullary nephrons in conscious
      rats.

PMID- 1026103
TI  - [Use of spatial size as guideline in non-invasive methods. 1. left and right
      heart block].

PMID- 1026104
TI  - [Effect of semantic stimulation on tonic postural activity].

PMID- 1026105
TI  - [Culdoscopy under general anesthesia].

PMID- 1026106
TI  - [Neuroleptanalgesia, digestive endoscopies and informatics].

PMID- 1026107
TI  - [Extraction of intravascular foreign bodies by catheterization: technic--results-
      indications].

PMID- 1026108
TI  - [Unusual investigation. Rare examinations in non-cooperative patients].

PMID- 1026109
TI  - [Technics proposed for difficult maxillo-facial intubations].

PMID- 1026110
TI  - [Peridural anesthesia in arteriography of the lower limbs].

PMID- 1026111
TI  - [Peridural anesthesia. Anesthesia of choice for arteriography of the lower limbs
      (a propos of 130 cases since 1971)].

PMID- 1026112
TI  - [Value of brachial plexus block as a method of anesthesia in arteriographic
      examination of the hand].

PMID- 1026113
TI  - [Alfatesine anesthesia in neuroradiology].

PMID- 1026114
TI  - [Anesthesia in neuroradiology with alfatesine and fentanyl administered by
      constant perfusion].

PMID- 1026115
TI  - [3 Cases of complications in the course of gaseous myelography].

PMID- 1026116
TI  - [Anesthesia in cardiac radiology. Problems posed by catheterization and
      angiography in children].

PMID- 1026117
TI  - [Value on an alfatesine-phenoperidine combination in selective abdominal vascular
      radiologic examinations (apropos of 120 cases)].

PMID- 1026118
TI  - [Anesthesia for coelioscopy in gynecology].

PMID- 1026119
TI  - [The use of ketamine anesthesia for coelioscopy].

PMID- 1026120
TI  - [Respiratory complications in coelioscopies perfomed under general anesthesia].

PMID- 1026121
TI  - [Capnography in carbon dioxide coelioscopies (a propos of 20 cases)].

PMID- 1026122
TI  - [Anesthesia for esophagoscopy in children and infants].

PMID- 1026123
TI  - [Anesthesia for cystoscopy].

PMID- 1026124
TI  - [Ultramicrotechnics for serum uric acid level determination].

PMID- 1026125
TI  - [Automatic ultramicrotechnic for the determination of plasma uric acid].
AB  - An automatic micromethod is described for the estimation of plasma uric acid. The
      hydrogen peroxide formed when uric acid is oxidised by uricase, condenses by
      oxidation two molecules of p-hydroxyphenil-acetic acid in the presence of
      peroxidase. The product formed (dicarboxymethyl-5,5' dihydroxy-2,2' biphenyl) is
      fluorescent. This method permits one to estimate quantitites of uric acid of the
      order of 1 microng and permits measurement of uric acid in 50 microll of plasma.
      The values obtained for human plasma are compared to those supplied by a
      reductrimetric technique (SMA 12-60).

PMID- 1026126
TI  - [Determination of colchicine in biological fluids].
AB  - The authors described a fluorimetric method of estimation of colchicine
      applicable to biological fluids, during treatment and, especially, during acute
      poisoning. Blood and urinary concentrations confirm the data in the literature.

PMID- 1026127
TI  - [Usual values of haptoglobin, protein-bound sialic acid and blood sedimentation
      in a population of the Cherbourg region].
AB  - The authors studied 3 parameters commonly used for the exploration of an
      inflammatory syndrome (determination of globular sedimentation rate at the first
      and second hour, concentration of plasma haptoglobin, sialic acid bound to plasma
      proteins rate). Haptoglobin and acid sialic assays were solely used in
      determining a control population (816 patients without any inflammatory
      reaction). As a matter of fact, the values we found complied with a normal
      distribution rule and confidence limits with a probability of 95% were obtained.

PMID- 1026128
TI  - Glucose-6-phosphate dehydrogenase of Biomphalaria glabrata (Say , 1818)
      (Mollusca: Pulmonata). Characterization and inheritance pattern.
AB  - Glucose-6-phosphate dehydrogenase of Biomphalaria glabrata has been characterized
      by electrophoresis, kinetic properties and inheritance pattern. It exists as a
      single electrophoretic band with no polymorphism in the natural population
      studied during the present investigations. There are no organ-specific
      differences in electrophoretic pattern. The enzyme from the homogenates of
      various organs e.g., albumen gland, digestive gland, ovotestis and columellar
      muscle show similar physico-chemical parameters, such as optima for pH, NADP and
      glucose-6-phosphate. Incorporation of NADP is essential for maintaining the
      stability of the enzyme, failing which, there appear artifactual variations in
      electrophoretic mobility of the enzyme. The apparent lack of polymorphism in
      natural population of Biomphalaria glabrata has been discussed.

PMID- 1026129
TI  - [Sacro-coccygeal dysplasia and megarrectum in children (author's transl)].
AB  - 35 cases of megarrectum associated with lumbo-sacro-coccygeal dysplasis are
      reviewed. 32.7% of the dysplasia were sacral. Nine cases were ultrashort
      aganglionic segments. Symptoms were variable, of early onset (82.7% before one
      year) and mild (57.1% required medical advise after three). Medical management
      was useful in the non aganglionic group whereas it was ineffective in the
      aganglionic group. Sphincteric myotomy was the more common operation used.
      Physiopathology and modalities of treatment are discussed.

PMID- 1026130
TI  - [Gallstones in children. Report of one case and review of the literature
      (author's transl)].
AB  - A 12 year old boy is presented with choleithiasis and cholecystitis diagnosed by
      oral cholecistogram and intravenous cholangiogram and managed surgically with a
      cholecystectomy. A review of 667 cases of cholelithiasis in children is presented
      from literature, since the first report of gallstones in 1737, until 1975. It is
      showed that childhood cholelithiasis is a uncommon disease, occurring in all ages
      but (commoner) in preadolescent and adolescent girls. Etiologic significance of
      obesity, family history of cholelithiasis, pregnancy and history of previous
      abdominal surgery is reported. Haemolytic disease is an underlying etiologic
      agent in less than 19% of 416 cases reviewed. A high percentage of gallstones
      were visible on plain films of the abdomen and oral cholecystograms were
      diagnostic of cholelithiasis or showed changes highly suggestive of gallstones in
      86% of cases reviewed. In a child with abdominal pain of unknown etiology, it is
      imperative to exculade the possibility of gallstones, and plain films of the
      abdomen and oral cholecystography are the best investigative techniques to do
      this.

PMID- 1026131
TI  - [Unilateral brain edema in a case of Reye's syndrome (author's transl)].
AB  - A case of Reye's syndrome is reported with peculiar characteristics of
      neurological focality and important cerebral edema of the opposite side. The
      present knowledge of genetic factors in the development of Reye's syndrome
      encephalopaty is briefly discussed and, also, the possible vascular role in this
      definite case.

PMID- 1026132
TI  - [Prejudices and psychiatry. Results of a survey among medical students].
AB  - The purpose of this survey was to know better the image of mental illness among
      the public. A 28 items questionnaire tried to summarize the main set-ideas
      usually held in this respect. It was submitted to a group of medical students.
      The answers obtained indicate quite clearly the force and continuity of some of
      these set-ideas: more complicated illness, often incurable, of which the number
      is constantly increasing; bad reputation of electrochocs. They also show an
      evolution of the state of minds concerning the differenciation of different types
      of illnesses, the alleged origins of mental illnesses and eventually the role and
      importance of psychotherapy in their treatment. Eventually a "free-opinions"
      section, underlined the common interest for the social condition of the mental
      patient, the responsibility of social factors in the genesis or the appearance of
      his troubles and above all for the "character" of psychiatrist. Conclusions drawn
      from this survey only have a relative value, but are encouraging enough to
      justify a larger and deeper one.

PMID- 1026133
TI  - [Development of psychotic symptomatology in old age as a function of the
      environment].

PMID- 1026134
TI  - [A functional conception of language: theoretical and methodological
      considerations].

PMID- 1026135
TI  - [Latent demand, manifest demand, answers of a psychiatrist, if not of the art
      itself].

PMID- 1026136
TI  - [10-year development of a psychiatric hospital's equipment].

PMID- 1026137
TI  - [Incidence of brucellosis in psychiatry (apropos of 20 cases)].

PMID- 1026138
TI  - [Pathogenic discussion and medico-legal implications in chronic delusions apropos
      of a case].

PMID- 1026139
TI  - [The container-contents duality in the schizophrenic. Symbolic value of some
      initial signs in the long-term prognosis of schizophrenia].

PMID- 1026140
TI  - [Electroencephalographic study during long-term use of nicergoline].

PMID- 1026141
TI  - Hygiene standard for impulse noise from the Committee on Hygiene Standards of the
      British Occupational Hygiene Society.

PMID- 1026142
TI  - Calculated in-ear A-weighted sound levels resulting from two methods of hearing
      protector selection.

PMID- 1026143
TI  - Characterization of respirator adsorbent filters by means of penetration curve
      parameters.

PMID- 1026144
TI  - An international comparison of counts of airborne asbestos fibres sampled on
      membrane filters.

PMID- 1026145
TI  - Particle size distribution and human respiratory deposition of trace metals in
      indoor work environments.

PMID- 1026147
TI  - Evaluation of natural wet bulb and wet globe thermometers.

PMID- 1026146
TI  - An investigation of lead workers for subclinical effects of lead using three
      performance tests.

PMID- 1026148
TI  - A comparison of reactions to industrial protective clothing.

PMID- 1026149
TI  - Toxicity of combustion products with particular reference to polyurethane.

PMID- 1026150
TI  - Short-term exposure limits.

PMID- 1026151
TI  - Preventing emissions from manufacturing processes by suitable process design.

PMID- 1026152
TI  - Monitoring local exhaust ventilation systems.

PMID- 1026153
TI  - Controlling vapours from open surface vessels.

PMID- 1026154
TI  - Cleaning exhaust ventilation air.

PMID- 1026155
TI  - Organizing the engineering control of toxic substances in air.

PMID- 1026156
TI  - The measurement of shift average exposures to oxides of nitrogen.

PMID- 1026157
TI  - Personal protection--the last resort?

PMID- 1026158
TI  - Modern concepts of respiratory protection.

PMID- 1026159
TI  - Effect of head band forces and pressure on comfort of ear muffs.

PMID- 1026160
TI  - The performance of nebuliser and air ejector made from sections of hypodermic
      needles.

PMID- 1026161
TI  - [Ether and penthrane on LH and prolactin (author's transl)].
AB  - The effects of long-term anesthesia with methoxyflurane on plasma LH and
      prolactin concentrations were compared to those induced by exposure to ether.
      Methoxyflurane significantly decreased prolactin levels and had a slight effect
      of LH, whereas ether produced an important release of prolactin without affecting
      LH.

PMID- 1026162
TI  - [Immunoreactive "beta-MSH-like" substances in human plasma (author's transl)
      (proceedings)].

PMID- 1026163
TI  - [Circadian rhythm of neurophysiologic and endocrinologic variables during a
      hyperbaric situation: simulated dive at 610 M in helium-oxygene atmosphere
      (author's transl) (proceedings)].

PMID- 1026164
TI  - [Endocrinologic aspect of the circannual temporal structure of five healthy young
      parisian males (author's transl) (proceedings)].

PMID- 1026165
TI  - [Prolactin cell pituitary adenoma associated with an intrathyroidal parathyroid
      adenoma (author's transl) (proceedings)].

PMID- 1026166
TI  - [Precocious puberty -- third ventricle arachnoidian cyst and cyproterone acetate
      (author's transl) (proceedings)].

PMID- 1026167
TI  - [Durable puberal gynecomastias: hormonal studies (author's transl)
      (proceedings)].

PMID- 1026168
TI  - [Cushing's disease successfully treated by transphenoidal hypophysectomy since
      eight years (author's transl) (proceedings)].
AB  - The authors show a case of true Cushing's disease by bilateral adrenal
      hyperplasia without pituitary tumor which is cured for eight years by only
      treated with transphenoidal hypophysectomy. They think that reaching by surgery,
      the nervous afferences from hypothalamus to hypophysis could play a part in
      ameliorating the pathologic relations which existed between two centers.

PMID- 1026169
TI  - [Osteomalacia and anticonvulsant therapy: serum assay of 25 hydroxy D in an
      epileptic population (author's transl) (proceedings)].

PMID- 1026170
TI  - [Assay of circulating 25-hydroxy-vitamin D (author's transl) (proceedings)].

PMID- 1026171
TI  - [Interaction of androgens and gonadotrophins within the ovary of immature rat
      (author's transl) (proceedings)].

PMID- 1026172
TI  - [Seasonal variations in the concentration of ABP in rete testis fluid (RTF) of
      the ram (author's transl) (proceedings)].

PMID- 1026173
TI  - [Teleost fish (Gobius niger) vitellogen proteins in plasma and liver under
      hormonal treatments (author's transl) (proceedings)].

PMID- 1026174
TI  - [Suppression of the seasonal cycle of testicular activity by cold exposure in the
      garden dormouse (Eeliomys quercinus L.) (author's transl) (proceedings)].

PMID- 1026175
TI  - [Kinetic study of the metabolism and urinary excretion of cortisol in the
      isolated perfused rat kidney (author's transl) (proceedings)].

PMID- 1026176
TI  - [Effects of testosterone on muscle, adipose mass, number and volume of adipocytes
      in deltoid and trochanteric areas (author's transl) (proceedings)].

PMID- 1026177
TI  - [Oestrogens and calcitonin (author's transl) (proceedings)].

PMID- 1026178
TI  - [Evidence of TSH-inhibiting factor by hypophysis grafting technique (author's
      transl) (proceedings)].

PMID- 1026179
TI  - [TSH effect in mammals in normal conditions or in hypothermia (author's transl)
      (proceedings)].

PMID- 1026180
TI  - [Cytochemical observation of TSH fixation by the human neutrophil granulocyte
      membrane (in vitro) (author's transl) (proceedings)].

PMID- 1026181
TI  - [Neuro-endocrinology and human pigmentation disturbs (author's transl)
      (proceedings)].

PMID- 1026182
TI  - [Total and unbound plasma cortisol and transcortin in hyper and hypothyroidism
      (author's transl) (proceedings)].

PMID- 1026183
TI  - [Hyperthyroidism and thyroid carcinoma. Report of two cases (author's transl)
      (proceedings)].

PMID- 1026184
TI  - [Plasma renin activity in myxoedema (author's transl) (proceedings)].

PMID- 1026185
TI  - [Action of insulin on the thyroid protein synthesis in dogs (author's transl)
      (proceedings)].

PMID- 1026186
TI  - [Summary glycogen in carp after glucagon or insulin injection (author's transl)
      (proceedings)].

PMID- 1026187
TI  - [Endocrinology and gregariousness in locusts. II. The brain (author's transl)
      (proceedings)].

PMID- 1026188
TI  - [Juvenile hormone and vitellogenesis in male of Pieris brassicae L. (Lepidoptera)
      (author's transl) (proceedings)].

PMID- 1026189
TI  - [Proteic vitellogenesis of bombyx mori L. (Lepidoptera) in male as well as in
      female bodies, is not endocrine dependant (author's transl) (proceedings)].

PMID- 1026190
TI  - [Median protocerebral neurosecretion and absorbant activity of the rectum in the
      locust Locusta migratoria migratorioides (author's transl) (proceedings)].

PMID- 1026191
TI  - [Pigment and diapause in lepidoptera (author's transl) (proceedings)].

PMID- 1026192
TI  - [Biosynthesis and excretion of pigmentary compounds during the last larval instar
      in Lepidoptera (author's transl) (proceedings)].

PMID- 1026193
TI  - [Hormonal controls of ommochrome metabolism in the migratory Locust Locusta
      migratoria L. (Orthoptera, Acrididae) (author's transl) (proceedings)].

PMID- 1026194
TI  - [Endocrinology and gregariousness in locusts. I. Corpora allata and ventral
      glands (author's transl) (proceedings)].

PMID- 1026195
TI  - [Spectrofluorimetric dosage of epiphysal and encephalic serotonin in Symphodus
      melops (author's transl) (proceedings)].

PMID- 1026196
TI  - Influence of embryonic and adult testis on the differentiation of embryonic ovary
      in the mouse.
AB  - The development of 11 1/2-13 1/2-day embryonic mouse ovaries subjected to the
      influence of adult and embryonic testes was investigated. The environment of
      adult testis caused severe restriction of ovarian growth, but did not produce any
      effects which might be considered as masculinization. The presence of embryonic
      testis was distinctly unfavourable to the embryonic ovary, resulting in
      restriction of the growth of the latter and degeneration of oocytes. Reversal of
      the course of differentiation of genetically female germ cells has never been
      observed.

PMID- 1026197
TI  - [Mycotoxins in food].

PMID- 1026198
TI  - [Tetanus in Belgium, 1975].

PMID- 1026199
TI  - The replacement of serum by hormones in cell culture media.
AB  - The replacement of serum by hormones in cell culture media. (Reemplazo del suero
      por hormonas en el medio de cultivo de celulas). Arch. Biol. Med. Exper. 10: 120
      121, 1976. The serum used in cell culture media can be replaced by a mixture of
      hormones and some accesory blood factors. The pituitary cell line GH3 can be
      grown in a medium in which serum is replaced by triiodothyronine, transferrin,
      parathormone, tyrotrophin releasing hormone and somatomedins. Hela and BHK cell
      strains can also be grown in serum free medium supplemented with hormones. Each
      cell type appears to have different hormonal requirements yet it may found that
      some hormones are required for most cell types.

PMID- 1026200
TI  - Cell membrane and cell junctions in differentiation of preimplanted mouse
      embryos.
AB  - Cell membrane and cell junctions in differentiation of preimplanted mouse
      embryos, (membrana celular y uniones celulares en la diferenciacion del embrion
      de raton antes de la implantacion). Arch. Biol. Med. Exper. 10: 130-134, 1976.
      The development of cell junctions that seal the peripheral blastomeres could be a
      decisive step in the differentiation of morulae into blastocysts. The appearance
      of these junctions is studied by electron microscopy of late morulae and initial
      blastocysts. Zonulae occludentes as well as impermeability to lanthanum emulsion
      precedes the appearance of the blastocel and hence might be considered as one of
      its necessary causes.

PMID- 1026201
TI  - Hormone action on the cell nucleus: effect of erythropoietin and testosterone on
      bone marrow.
AB  - Experiments intended to correlate the biochemical action of erythropoietin and
      testosterone on marrow cells are presented. Both hormones seem to act at
      different cytological and biochemical levels. Erythropoietin triggers the
      erythropoietic phenomenon acting on the Erythropoietin-Sensitive Cells. Inducing
      the synthesis of a large size RNA, (85S) which after a ribonuclease-dependent
      processing mechanism generates the informational RNA (9S) required for hemoglobin
      synthesis. Testosterone acts directly on bone marrow (probably at the level of
      polychromatophylic erythroblasts) enhancing the synthesis of ribosomal RNA or its
      precursors and stimulates a nuclear ribonuclease which might represent a control
      mechanism on the processing of high molecular weight RNAs. It is postulated that
      erythropoietin and testosterone act synergistically to create the biochemical
      machinery for hemoglobin synthesis.

PMID- 1026202
TI  - [Preliminary studies on alveolar cells type II during a course of intraoperative
      atelectasia in patients undergoing lobectomy].

PMID- 1026203
TI  - [Combination of Hodgkin's disease with malignant epithelial neoplasms.
      Illustrations of 4 observed cases].

PMID- 1026204
TI  - [Toxoplasmosis of the lymph glands].

PMID- 1026205
TI  - [Ultrastructural study of toxoplasmosis of the lymph glands].

PMID- 1026206
TI  - [Ultrastructural study of the skeletal muscle in localized scleroderma].

PMID- 1026207
TI  - [Ultrastructural morphological aspects of alveolar cells type II after ligation
      of the pulmonary artery in patients undergoing lobectomy].

PMID- 1026208
TI  - [Congenital liver fibrosis. Reference to a case and review of literature].

PMID- 1026209
TI  - [Tumors of the carotid body among recent problems of neuro-endocrinal neoplasms].

PMID- 1026210
TI  - [Acute septal myocardial infarct in an 8-year-old child with obstructive
      hypertrophic myocardiopathy].

PMID- 1026211
TI  - [Morphological studies on the subject of neurobrucellosis].

PMID- 1026212
TI  - [Adenomatous villous polyp of the large intestine as a cause of serious loss of
      electrolytes. Report of a case].

PMID- 1026213
TI  - [Studies with the freeze etching method on circulating blood platelets in
      patients with dyslipemia and in experimental hypercholesteremia. Preliminary
      note].

PMID- 1026214
TI  - [Epidermoid carcinoma of the breast imposed on ductal papilloma].

PMID- 1026215
TI  - Intercountry coordination in the development of manpower.

PMID- 1026216
TI  - [Bilharziasis in Kinshasa. Current data and future danger. Malacologic, biologic,
      clinical and epidemiologic studies].

PMID- 1026217
TI  - [Trial of the technic of visualization of amebic liver abscesses by tomography
      after perfusion of triiodobenzoic acid salts].

PMID- 1026218
TI  - [Gout in Rwanda].

PMID- 1026219
TI  - [Studies on the ultrastructure of the contractile myocardium in birds].

PMID- 1026220
TI  - [Structure of the fusiform proprioceptors of the extrinsic ocular muscles in the
      calf].

PMID- 1026221
TI  - [Relationship between the proximal limits of the mucous and muscular antrum in
      man].

PMID- 1026222
TI  - [Myoepithelial cells of the cutaneous glands in various amphibia].

PMID- 1026223
TI  - [Recent studies on human biomorphology. Elaboration of medium values on 13
      parameters of 1839 subjects of female sex and transversal studies on their
      temporal modifications during 8 years. Comparative biomorphological aspects of
      somatotypes in the provinces of palermo, agrigento and trapani].

PMID- 1026224
TI  - [Development of interscapular brown adipore tissue in the rat (Epimus norv.
      Erxl.)].

PMID- 1026225
TI  - [Method of x-ray osteophotometry of the lumbar region of the spinal column].
AB  - The content of mineral salts in all diseases of the skeleton has greater or less
      deviations from the norm. The change of the mineral content can be visually
      determined in routine roentgenograms when the deviation is not less than 20-30%
      from normal. This estimation has a great share of subjectivism. The optical
      density of the bone in roentgenogram objectively shows the content of calcium
      salts and its structure. Under study was the influence of soft tissues
      surrounding the lumbar part of the vertebral column upon the optical density
      index. Ten preparations of lumbar divisions by means of the aluminium wedge.

PMID- 1026226
TI  - [Transitional forms of the cervical and first ribs].
AB  - The upper ribs possessing the signs of both cervical and first ribs (such as the
      size, conjunction with the sternum, dilatation of the superior intercostal
      spaces, double width and others) are the intermediate forms. Small dimension
      fluorography of 400.000 humans with roentgenographical control has revealed 468
      persons with transitional forms of cervical and first ribs (0,12%), i. e. one
      case per 800 humans at an average. Transitional forms of cervical and first ribs
      can be grouped as follows: asymmetry of clavicles, asymmetry of the upper ribs,
      close position of the upper ribs, double width of the first ribs, conjunction of
      the cervical and first ribs at the vertebrum.

PMID- 1026227
TI  - [Morphometric study of the postnatal development of the human adrenal cortex].
AB  - Under study was the developmental dynamics of a number of morphometrical
      parameters of the adrenal cortex of man. The number of glandular cells in the
      organ was found to considerably decrease at late developmental periods, the size
      of nuclei in them diminished. These factors are considered to be responsible for
      the drop of functional activity of the adrenal cortex in elderly and senile age.
      The increase of the cell size during the growing of the organism is thought to be
      an important factor of the growth of the adrenal cortex of man.

PMID- 1026228
TI  - [State of Dogiel type II neurons in the wall of the cat small intestine following
      a single exposure to gravitational stress].
AB  - Under study was the nervous apparatus of the small intestine in 22 cats subjected
      to a single gravitation stress by rotation in a centrifuge of 1,5 m radius. The
      stress was equal to 10 units, duration from 2,5 to 3,5 min., and was of head
      pelvis direction. The material was treated after Nissl and Gomori in
      Chilingarian's modification. Within 1-3 days after exposure to gravitation
      stresses in the Auerbach plexus there appeared changes in the shape of the body
      of the type II Dogiel cells, such as pericellular oedema, vacuoles in the
      cytoplasm, chromatolysis and varicous thickenings of nerve fibres. Terminal
      structures of the dendrites of the type II Dogiel cells are thickened. The
      changes are most pronounced within the 4th-7th days after exposure to gravitation
      and are observed as late as the 14th day, being sharply diminished by the 30th
      day.

PMID- 1026229
TI  - [New methods of x-ray anatomic study (on the 80th anniversary of x-ray anatomy)].
AB  - Eighty years have passed since 1896 when Tonkov first used X-rays in anatomy in
      our country. The first Roentgenological Institute was organized in the USSR in
      Leningrad in 1918 with the first roentgenanatomical laboratory in it. This
      laboratory has first developed methods of the roentgen-anatomical investigation
      of the vascular system such as roentgenarteriography (A. S. Zolotukhin),
      roentgenlymphography, tomography, microroentgenography, bukkigraphy and others
      (M.G. Prives and others). The article presents a review of the newest methods of
      roentgenanatomical investigations: roentgenography with direct magnification of
      the picture, roentgenography of soft tissues, electro-roentgenography,
      panthomography, coloured roentgenography, different kinds of artificial
      contrasting-pneumography of different kinds, partenography,
      roentgenostereography, newest kinds of arteriography, phlebography,
      portohepatography, lymphography, pharmaco-angiography, roentgenokinography and
      teleroentgenkinography.

PMID- 1026230
TI  - [New growth of interneuronal connections in the neocortex of adult rats under
      conditions of secondary epileptogenesis].
AB  - The synaptic organization of the parietal cortex in the zone of a chronic mirror
      epileptic focus was studied in rats electron microscopically. The
      synaptoarchitectonics was found to change as compared with control material in
      the mirror focus. Part of synapses were reduced due to degeneration of
      interhemisphere fibres. The amount of fine preterminal axons and axo-axonal
      contacts increased, the organization of complex synaptic conjunction grew more
      complicated. These data suggest possible newformation of interneuronal
      connections under the influence of an intensive stream of impulses from the
      primary focus.

PMID- 1026232
TI  - The psychological and social effect of design.

PMID- 1026231
TI  - Appearance of morphologically aberrant cells of Micrococcus lysodeikticus
      (luteus) in medium with papain.

PMID- 1026233
TI  - USA--women health workers.

PMID- 1026234
TI  - Complexity and order of the human circadian system.

PMID- 1026235
TI  - Intracellular potentials of cortical neurons and surface activity: I) During
      epileptogenic discharges induced by pentylenetetrazole in rats.

PMID- 1026236
TI  - Intracellular potentials of cortical neurons and surface activity: II) During
      epileptogenic discharges induced by strychnine in the rat.

PMID- 1026237
TI  - [Maternal and dietary contribution to the skeletal mineralization in the rat
      fetus].

PMID- 1026238
TI  - [Kinetics of the ionophore interaction with proton translocation in the
      mitochondrial membrane].

PMID- 1026239
TI  - [Changes in the body composition of obese subjects during starvation].

PMID- 1026240
TI  - [Behavior of urinary nitrogen in obese subjects during starvation].

PMID- 1026241
TI  - [Distribution of acid phosphatase activity in white blood cells].

PMID- 1026242
TI  - [Weight of adult laboratory animals. Definition of basal conditions].

PMID- 1026243
TI  - [Effect of hormones and chemical mediators on various functional parameters of
      the rabbit heart. XI. Effect of estradiol].

PMID- 1026244
TI  - [Carotenoids of Axinella verrucosa (Demosponge tetractinomorphae)].

PMID- 1026245
TI  - [Identification and determination of cephalosporin by means of high pressure
      liquid chromatography].

PMID- 1026246
TI  - [The Albumen gland of Helix aspersa. Research using light and electron
      microscopy].

PMID- 1026247
TI  - [Nature and significance of the so-called Cajal's "interstitial cells" in the
      human esophagus and stomach].

PMID- 1026248
TI  - [Ultrastructural pictures of myoneural junctions in the esophagus and stomach of
      man].

PMID- 1026249
TI  - [Changes in the intestinal absorption of glucose within the function of age].

PMID- 1026250
TI  - Salt discriminating properties in single tarsal hairs of Phormia regina M.

PMID- 1026251
TI  - [Biosynthesis of hemoglobins in vitro in a special case of thalassemia].

PMID- 1026252
TI  - [Screening for the identification of thalassemias: studies on hospital population
      of 3903 cases].

PMID- 1026253
TI  - [Effect of metoclopramide on the secretion of prolatin in man].

PMID- 1026254
TI  - [Combined effects of tenotomy and denervation on the rapid muscle in the rat].

PMID- 1026255
TI  - [Relationship between onset of obesity and cellularity of adipose tissue].

PMID- 1026256
TI  - [LSD-25 and UML decrease the levels of 5-hydroxyindoleacetic acid in the brain of
      rat].

PMID- 1026257
TI  - [Effect of mescaline on the serotoninergic system of the rat brain].

PMID- 1026258
TI  - [LSD-25, tranylcypromine and the serotoninergic system of the rat brain].

PMID- 1026259
TI  - [Nature of the inherent luminescenece of Streptomyces olivocinereus, the producer
      of heliomycin].

PMID- 1026260
TI  - [Effect of glucose and ammonium ions on the synthesis of exoproteases by
      Actinomyces thermovulgaris T-54].

PMID- 1026261
TI  - [Thermostatic chamber for the isolated retina of cold-blooded animals].

PMID- 1026262
TI  - [Differential spectrophotometry of biological objects characterized by strong
      light diffusion].

PMID- 1026264
TI  - [Tick fauna of the family Raphignathidae Kramer, 1877].

PMID- 1026263
TI  - [Data on the chemical makeup of the horns of the saiga].

PMID- 1026265
TI  - [New and little known species of the family Dolichopodidae (Diptera) in the fauna
      of the USSR and adjacent territories].

PMID- 1026266
TI  - [Comparative study of the digestive organs of passerine birds (Corvidae)].

PMID- 1026267
TI  - [Transformation of the distribution function of random photic stimuli under
      conditions of binocular stimulation].

PMID- 1026268
TI  - The audio cassette library: a new credibility gap?

PMID- 1026269
TI  - The medical curriculum: making a production of it.

PMID- 1026270
TI  - Medical instant photography: the diagnostic picture.

PMID- 1026272
TI  - Medical instant photography: photomicrography & Polacolor 2.

PMID- 1026271
TI  - Medical instant photography: tips on picture quality.

PMID- 1026273
TI  - Medical instant photography: instant aid for a busy biophotographer.

PMID- 1026274
TI  - The free loan philosophy: the rationale behind Pharmaceutical program operations.

PMID- 1026275
TI  - Third annual directory of pharmaceutical programs.

PMID- 1026276
TI  - Physicians Radio Network: an alternative to eyestrain.

PMID- 1026277
TI  - [Device for the simultaneous detemination in tissue of the redox potential, free
      oxygen concentration and local blood flow].

PMID- 1026278
TI  - [Design of a bath for the perfusion of isolated lymphatic vessels].

PMID- 1026279
TI  - [Direct action of angiotensin II on the central neurons].
AB  - Reactions of the nervous cells in the somatosensory and visual regions of the
      brain cortex and the frontal hypothalamus in rabbits, as well as of the isolated
      nervous peripharyngeal ring of the Helix pomatia to the microionophoretic
      application of angiotensin II (A-II) was studied. Reactions of the neurons in the
      rabbit brain to A-II displayed an increase in the spike frequency depending on
      the quantity of the agent applied. Reactions of the frontal hypothalamus neurons
      showed a lower threshold than those of the brain cortex. A-II application to the
      some of the recorded cells of the mollusc evoked a marked reversible decrease in
      the membrane potential; as to the membrane resistance--it diminished 2--4 fold.
      These experimental data pointed to the direct A-II effect on the central neurons.

PMID- 1026280
TI  - [Effect of adaptation to altitude hypoxia in early ontogeny on the indices of
      higher nervous activity].
AB  - Newborn male and female Wistar rats were adapted to hypoxia in a pressure
      chamber. Adaptation was started from the "altitude" of 1000 m, 1 hour daily, and
      then the time and the intensity of hypoxic actions were gradually increased:
      beginning from the 17th day the animals were subjected to adaptation to the
      "altitude" of 5000 m, for 5 hours, 5 days a week. The defence conditioned reflex
      of active avoidance was provoked in the animals after 2-month adaptation. A
      tendency to a more rapid elaboration of the reflex and a markedly enhanced degree
      of its retention in comparison with control was revealed in the adapted males. No
      significant changes in the elaboration and rentention of the reflex were found in
      the female animals adapted to hypoxia under analogous conditions.

PMID- 1026281
TI  - [Thalamic inhibition of locomotion evoked by stimulation of the midbrain].
AB  - In the lightly anesthetized cat with an intact brain stimulation of the thalamic
      region with Horsley-Clarke cooordinates of its center A7 L2 H2 could suppress the
      locomotion elicited by stimulation of the subthalamic or midbrain "locomotor
      region".

PMID- 1026282
TI  - [Change in the evoked potentials of the brain exposed to a constant magnetic
      field].
AB  - The influence of the constant magnetic field (CMF) upon the cerebral and
      cerebellar cortex potentials evoked by the sciatic stimulation was studied in
      rats. During the exposure to the  CMF there occurred an increase of the evoked
      potentials in amplitude and the appearance of additional waves in their
      structure. The effect was enhanced with increase in the intensity of magnetic
      field within the range of 500-4000 oe.

PMID- 1026283
TI  - [Mechanism of the effect of the sympathetic nerves on kidney function].
AB  - The inhibitory action of the adrenergic fibers of the splanchnic nerve on the
      speed of diuresis, filtration, maximum secretion, potassium excretion in the
      kidney disappeared at the side of the stimulation and blood flow in both kidneys
      in dogs given high reserpine doses. The animals developed hyponatriemia,
      hyperkaliemia and oliguria.

PMID- 1026284
TI  - [Characteristics of the functional properties of the spinal cord motoneurons of
      old rats].
AB  - The mean membrane potential (MP) of old rats did not differ significantly from
      that in young mature rats ((58.4 +/- +/-1,4 mV and 56.6 +/- 1.26 mV,
      respectively). At the same time the frequency of detection of motor neurons with
      the MP OF 70 mV and more fell by 18.6%, and with the MP of 50-59 mV -increased by
      14.2% in the old, in comparison with the young animals. The direct excitability
      threshold in old rats decreased (3.0 +/- 3-10(-9) in young mature and 2.0 +/- 0.2
      10(-9) a in old rats; P  less than 0.02). The number of discharges per 50 msec of
      the neuron poliarization reached 4-5, constituting 80-100 pulse/min. When
      determined by the first two intervals the action potential frequency reached 125
      pulse/sec, and in the young mature rats--over 300 pulse/sec. The duration of
      antidromic spikes was increased (1.02 +/- 0.09 msec in young mature animals and
      1.65 +/- 0.14 msec in the old animals; P less than 0.001). The antidromic spikes
      of the neurons in old mature rats, as a rule, had no delayed depolarization.

PMID- 1026285
TI  - [Synaptic potentials in smooth muscle cells].
AB  - Investigations were carried out on smooth muscle cells (SMC) of rat and rabbit
      anococcygeus by the method of a double "sugar bridge" in the presence of
      tetraethylammonium (1 mM/1) in the Krebs solution. Stimulation of the muscle
      strip by the electric current rectangular pulse of the maximal value and of short
      duration caused the development of excitatory postsynaptic potentials (EP SP) in
      the rat and rabbit SMC, and of inhibitory postsynaptic potentials in the rabbit
      SMC. The value of postsynaptic potentials displayed a linear dependence on the
      level of the membrane potential. Elimination of chlorine ions from the external
      solution decreased the EP SP of the SMC of rabbit anococcygeus and shifted the
      reversion potential in the direction of sodium balance potential. Apparently
      generation of the EP SP of the SMC of rabbit anococcygeus was associated with the
      increased permeability of the membrane both for sodium and for chlorine ions.

PMID- 1026286
TI  - [2 phase of the working hyperemia of skeletal muscle].
AB  - The dynamics of the working hyperemia of cat m. gastrocnemius was studied by
      means of an electromagnetic flowmeter. Two phases could be distinguished in the
      increase in the rate of circulation. There proved to be a rapid increase of the
      blood flow during the I phase, and an abrupt reduction of this process during the
      II phase. The duration of the I phase failed to depend on the frequency of
      stimulation and on the number of the contracting motor units. The II phase was
      absent when the number of the contracting motor units was few or the frequency of
      stimulation was low. It is suggested that the dilatation of the precapillary
      arterioles is responsible for the I phase of the working hyperemia and the II
      phase is connected with the dilatation of the larger arteries.

PMID- 1026287
TI  - [Effect of a hypertonic sodium chloride solution on dye distribution in the
      organs and lymph of the thoracic duct].
AB  - The distribution of trephan blue in different organs and tissues and in the lymph
      was studied in acute experiments  on 84 dogs after the infusion of 5% NaCl
      solution (0.5 mg/kg). The rise of the stain concentration in the intact dogs was
      the greatest in the liver, the kidney and the intestine. The osmotic shift caused
      by the intravenous infusion of the hypertonic NaCl solution increased the blood
      plasma hyaluronidase activity, reduced the maximal accumulation time of the stain
      in the tissues and led to a 1.5-2 fold elevation in the stain concentration in
      the organs.

PMID- 1026288
TI  - [Characteristics of the function of the higher portions of the central nervous
      system of rats subjected to acute hypoxia in the antenatal period].
AB  - A reduction of motor activity, and of the orientative reflex, its more rapid
      extinction in comparison with control were seen in the sexually mature rats which
      sustained acute hypoxia during the antenatal period. The experimental animals
      displayed disturbances of the conditioned reflex activity indicating a worse
      fixation of the temporary association, weakening of the inhibitory process and
      reduction of the nervous process mobility. Epileptiform convulsions occurred in
      presentation of "difficult" experimental tasks. There was also noted an increase
      in convulsioness after the administration of threshold doses of carasol.

PMID- 1026289
TI  - [Dynamics of the dendrite and transcallosum potentials in the cerebral cortex in
      overheating].
AB  - Experiments were conducted on awake rabbits placed in a thermochamber at the
      temperature of 45 degrees C. The dendrite and the transcallosum potentials were
      examined in dynamics of the hyperthermia and after the restoration of the thermal
      homeostasis. The influence of high temperature was accompanied by an expressed
      inhibition of the amplitude of the dendrite potential, although to a lesser
      degree than of the transcallosum response. The data obtained could testify to a
      direct inhibitory thermal effect on the neuron elements of various layers of the
      cortex. Restoration of the cortical neuron function after the high degree
      hyperthermia occurred twenty-four hours after the body normothermia was reached.

PMID- 1026290
TI  - [Posthypoxic changes in the cerebral cortex of dogs in the late recovery period
      after 4-hour hypovolemic hypotension].
AB  - On the 14th-21st day of the restorative period after four-hour hypovolemic
      hypotension the level of total RNA decreased in the tissue of the gray matter of
      the brain by 20.9%, and of DNA-by 13%. In the postmitochondrial supernatant the
      concentration of prealbumins was reduced by 26.5%, alpha-globulins--19.2%, gamma
      globulins--by 59.8%; the concentration of albumins and beta-globulins was
      increased by 12.6% and 50.0%, respectively. The activity of acid cathepsins  rose
      by 50%, and of acid phosphatase--by 44%. The activity of total lactic
      dehydrogenase (LDH) and glutamic dehydrogenase failed to differ essentially from
      the control level. However, LDH isoenzyme spectrum changes towards the reduction
      of LDH3+4+5 from 31.9 to 14.2%. Analysis of densitograms of electrophoresis in
      polyacrylamide gel showed physico-chemical changes in the protein molecules
      similar in nature to the denaturation phenomenon. The Purkinje's cell count
      decreased in the cerebellum by 41.3% in comparison with control.

PMID- 1026291
TI  - [Thrombolytic activity of terrilytin and its effect on the coagulating system of
      the blood].
AB  - The preliminary incubation of fibrinogen with terrilytin in vitro delayed the
      formation of the clot and accelerated the subsequent lysis. Terrylitin (in vitro)
      prolonged the recalcification time, lowered the thromboplastic  activity and that
      of fibrinase, and also enhanced the fibrinolytic activity of the blood plasma. In
      experiments on dogs roentgenovasography revealed a considerable thrombolytic
      activity of terrilytin following its intravenous infusion to the animals with
      experimental thrombosis of the femoral veins.

PMID- 1026292
TI  - [Changes in the stages of nocturnal sleep in man with a lesion of the
      hypothalamus-brain stem structures].
AB  - Polygraphic study of nocturnal sleep in 18 patients with affection of the
      hypothalamo-mesencephalic structures showed a reduction of the duration of the II
      stage and a prolongation of the III and IV stages of slow sleep in comparison
      with the corresponding indices in the patients with involvement of the ponto
      bulbar structures (9) and in healthy persons (8) of control group. Analysis of
      the qualitative indices of the EEG of slow sleep (a relative amount of the sleep
      spindles per 1 min of the II stage, delta-index and the  delta-wave amplitude at
      the II and the IV stages) demonstrated a tendency to their increase in the
      patients with affection of the hypothalamo-mesencephalic structures. Patients of
      this group showed a decreased frequency of spontaneous changes of sleep from
      deeper to more superficial stages.

PMID- 1026293
TI  - [Action of KCN on intact and refractory thrombocytes].
AB  - The effect of low KCN concentrations (5-10(4) M) on the ADP-induced aggregation
      of intact and refractory rabbit platelets was studied. KCN did not change the
      aggregation of the intact platelets, but stimulated that of the refractory
      platelets. The effect of the inhibitor stimulating the aggregation was not
      connected with the release of additional amounts of ADP. A different sensitivity
      of the aggregation capacity of the intact and refractory cells to the partial
      inhibition of metabolism was discussed in terms of the suggested earlier
      "calcium" model of autoregulation of platelet aggregation.

PMID- 1026294
TI  - [Interaction of reversible inhibitors with the catalytic centers and allosteric
      sites of cholinesterases].
AB  - The kinetics of inhibition of the human red blood cell cholinesterase with
      galanthamine tacrine and oxazyl (ambenonium) and the effect of these drugs on
      chick, mouse, cat and rat blood plasma enzyme activity was studied. Galanthamine
      proved to bind with acetylcholinesterase in the anionic areas of the catalytic
      centres, oxazyl interacted in the area of the allosteric anionic site, and tacrin
      interacted with the hydrophobic areas of the enzyme.

PMID- 1026295
TI  - [Accelerin (factor V), the catobolic product of fibrinogen ].
AB  - The authors describe a method of obtaining a highly active and well purified
      human Ac-globulin (factor Y) preparation. Factor Y proved to be a part of the
      fibrinogen molecule--its intermediate transformation product under the effect of
      thrombin or some other enzyme analogous by its action.

PMID- 1026296
TI  - [Effect of exogenous DNA on the content and biosynthesis of endogenous DNA in rat
      bone marrow].
AB  - The influence of exogenous DNA on the content of endogenous DNA and the rate of
      biosynthesis was studied in rat bone marrow. After the injection of highly
      polymerized homologous DNA to intact rats the content of rat DNA per 1 gm of the
      bone marrow decreased within the first 3 days (the most marked fall occurred in 3
      days--by 36%), and returned to the normal by the 6th day. The rate of DNA
      biosynthesis in rat bone marrow increased in 18 hours (doublled in comparison
      with control), remained elevated within 6 days (by 58%) and approached the normal
      level from 1 to 3 days after the DNA injection.

PMID- 1026297
TI  - [Study of rat erythrocyte superoxide dismutase activity during a toxic regimen of
      interrupted hyperbaric oxygenation].
AB  - Development of toxic manifestations in rats under conditions of hyperoxia was
      accompanied by a significant lowering of the rat erythrocyte superoxide dismutase
      activity. The incubation of control rats hemolysate with hydrogen peroxide (10(
      3)M) or with kumole peroxide (1.6 10(-4)M) also led to pronounced fall of the
      initial erythrocyte superoxide dismutase activity. As supposed, the lowering of
      the erythrocyte superoxide dismutase activity under hyperoxia could be due to the
      formation of peroxidation products.

PMID- 1026298
TI  - [Physicochemical properties of the human lymphocyte mitogenic factor induced by
      phytohemagglutinin].
AB  - Some physical and chemical properties of the mitogenic factor (MF) produced in
      vitro by PHA-stimulated human lymphocytes were investigated. Treatment of the
      culture medium with proteases proved to decrease the MF activity sharply. The MF
      was found to have an elution pattern in Sephadex and Bio-gel gels similar to
      proteins with the molecular weight of 20 000--30 000 daltons (peak--25 000). In
      experiments with the MF fractionation by disc-electrophoresis on 5% polyacylamide
      gel the MF formed a few discrete peaks in the fractions corresponding to the
      mobility of alpha1- and alpha2-globulins and transferrin. In isoelectric focusing
      the MF formed 3 fractions in the pH range of 4.5--8.3. Functional heterogeneity
      of the MF is suggested.

PMID- 1026299
TI  - [Role of clasmatosis of the phagocytes in immunogenesis].
AB  - With the aid of cytological and cytochemical studies it was shown that
      clasmatosis of phagocytes (micro- and macrophages) was primarily characteristic
      of active phagocytising cells, and not of dying cells as considered formerly.
      Experiements were conducted on guinea pigs in the course of vaccinal and
      infectious processes in brucellosis. As noted, clasmatosis of phagocytes known in
      intact animals was considerably enhanced during vaccinal and infectious
      processes. Pieces of cytoplasm separating from phagocytes were full of acid
      phosphatase, brucella antigen; fragments of macrophage cytoplasm in addition
      contained RNA. There are reasons to suppose that with the aid of clasmocytosis of
      phagocytes became intensified and the antigenic information spread rapidly in the
      animal organism.

PMID- 1026300
TI  - [Cytotoxicity of sera against brain and spinal cord antigens in relation to
      lymphocytes of varying origin].
AB  - Rabbit sera against antigens prepared from the brain and the spinal cord antigens
      were investigated in a cytotoxic test with mouse and guinea pig lymphocytes. None
      of the sera exerted a cytotoxic effect on the bone marrow lymphocytes. The sera
      against mouse brain and spinal cord and guinea pig brain and myelin isolated from
      it exerted the greatest cytotoxic activity; the cytotoxicity was maximum against
      the thymocytes, less pronounced against the lymph node lymphocytes, and least-
      against the spleen cells. The cytotoxicity of the sera against the bovine spinal
      cord homogenate, myelin and the basic protein isolated from it was the minimal
      and equal with lymphocytes from any of the three mentioned sources. The serum
      against the encephalitogenic polypeptide 2c was practically devoid of the
      cytotoxic activity. The encephalitogenic activity of the 2c fraction was greater
      than that of the myelin and basic protein from the bovine spinal cord. Experiment
      of antibrain serum absorption suggested that the brain cortex contained a cross
      reacting antigen. The subcutaneous injection of a relatively high dose (224 x
      10(6)) of thymocytes in the complete Freund's adjuvant failed to induce the
      development of allergic encephalomyelitis in guinea pigs.

PMID- 1026301
TI  - [Effect of bilateral destruction of the structures of the medial hypothalamus on
      the course of anaphylactic shock].
AB  - Anaphylactic shock induced in rabbits by the preliminary injury of various areas
      of the medial hypothalamus coursed more severly than in control. Irrespective of
      the localization of the foci of injury a more pronounced hypotensive reaction and
      a slower compensatory elevation of the blood pressure occurred in response to the
      administration of the  reactive dose of the antigen. The severity of anaphylactic
      shock depended on the time lapse from the moment of hypothalamic injury to the
      moment of administration of the reactive dose of the antigen.

PMID- 1026302
TI  - [Cortisol metabolic intensity in the liver of guinea pigs in allergic processes
      of the immediate and delayed types].
AB  - The intensity of cortisol metabolism was studied under conditions of perfusion of
      the liver in situ by solutions containing cortisol in different concentrations;
      in this case metabolism coursed chiefly in the direction of cortisone formation.
      With the increase of cortisol concentration in the inflowing perusate there was
      also a rise in the intensity of its metabolism in the hepatic tissue. In
      anaphylactic alteration of hepatic tissue the intensity of cortisol
      transformation into cortisone decreased, this pointing to disturbances of
      cortisol oxidation. Experimental allergic encephalomyelitis is also acccompanied
      by a reduction in the intensity of cortisol metabolism.

PMID- 1026303
TI  - [Experimental sensitization with an extract of Dermatophagoides pteronyssinus
      ticks].
AB  - Immunogenic properties of Dermatophagoides pteronyssinus ticks were studied in
      subcutaneous injection of the antigen to guinea pigs and rabbits. Marked changes
      in the immunological reactivity of the animal organism were revealed; these
      changes were accompanied by production of agglutinating, sensitizing the mast
      cells and precipitating (in rabbits) antibodies, and by the development of
      hypersensitivity of the immediate and delayed type.

PMID- 1026304
TI  - [Kinetics of cell populations in the compartment of maturing, non-dividing
      neutrophils of rat bone marrow].
AB  - The kinetics of cell movement through the compartment of maturing, nondividing
      neutrophils of the Wistar rat bone marrow was studied by autoradiography using H3
      thymidine. There were transit and reserved neutrophil populations in each cell
      compartment. The transit periods of the maturing nondividing cells, the mean time
      of cell renewal in the subcompartments of metamyelocytes, the band and the
      sementonuclear neutrophils were determined with consideration to the reserved
      cell population.

PMID- 1026305
TI  - [Cytological analysis of the intact and regenerating liver of different strains
      of rats].
AB  - Comparative cytological studies were conducted on control and regenerating liver
      of two strains (August and Cotton) of rats, 2/3 of the liver was resected; 5 or 6
      animals were sacrificed at each of the following postoperative periods: in 30
      hours, 3, 8, 42 and 120 days. The number of binuclear cells, the size of
      mononuclear hepatocytes and their nuclei, the mitotic activity, and ploidity of
      hepatocytes were determined. The intact and regenerating liver of the August rats
      differed from the intact and regenerating liver of the Cotton rats by a number of
      cytological indices, excluding the mitotic activity. A conclusion was drawn that
      the observed interstrain differences in the cytological indices providing
      regeneration of the liver after resection in the August and Cotton rats depended
      on the genotype of the given strain.

PMID- 1026306
TI  - [Study of the specificity of the estradiol-binding system in the uteri of guinea
      pigs].
AB  - The authors analyzed the affinity of the steroids belonging to the estran series
      to the estradiol-binding system of the guinea pig uteri. The presence of free
      hydroxyl groups in positions 3 (phenol) and 17beta and their interorientation
      proved to determine the interaction with the recptor system of the guinea pig
      uterus. The data obtained indicated that the biological activity of the steroids
      was  determined by the peculiarities of their structural interaction with the
      receptor systems of the uteri.

PMID- 1026307
TI  - [Proliferation of the myoctes of the left atrium and ventricle after different
      kinds of myocardial injuries in adult rats].
AB  - Myocardial infarction of the left ventricle was induced in adult rats weighing
      120-160 g by ligation of the left coronary artery at various levels: in the area
      of the auricle, of the first  third of the left ventricle, and in the middle of
      it. The left auricle was injured in the other experimental series: the ligature
      was applied to its anterior wall or to the auricular appendage. Sham-operated
      animals served as control; only pericardium was  removed in them. The left half
      of the heart was examined on the 5th postoperative day. Mitosis of myocytes was
      found in the auricle or in the auricular appendage of the animals in those
      experimental series in which these sections of the heart were injured directly
      and had a thickened epicardium (in 35 of 49 cases); mitotic index varied from 0.9
      to 10%. No mitoses were found in the myocytes of the auricle and the auricular
      appendage after ligation of the coronary artery in the middle of the ventricle.
      Mitoses in the myocytes of the ventricle were rare (in 7 of 49 cases) and were
      located far from the site of infarction, in the subepicardial region; mitotic
      index here varied from 1 to 2%.

PMID- 1026308
TI  - Multi-Media ACP self-learning series set for distribution to subscribers.

PMID- 1026310
TI  - Health maintenance organizations: an overview. Part I.

PMID- 1026309
TI  - MIST - what is it?

PMID- 1026311
TI  - Executive vice president's rounds: Governance by consensus.

PMID- 1026312
TI  - Board of regents statement: recertification and relicensure.

PMID- 1026313
TI  - Health Maintenance Organizations: part II. Some frequently asked questions.

PMID- 1026314
TI  - Executive vice president's rounds: internal medicine and primary care.

PMID- 1026315
TI  - Oral examinations: pro and con.

PMID- 1026316
TI  - Recertification: has it touched your life?

PMID- 1026317
TI  - Executive vice president's rounds: the College and continuing medical education
      in South America.

PMID- 1026318
TI  - State legislation: its growing regulative domain.

PMID- 1026319
TI  - ACP Major Hospital Expense Insurance.

PMID- 1026320
TI  - [Microbiology of drugs].

PMID- 1026321
TI  - [Presentation of rheoencephalography].

PMID- 1026322
TI  - Lassa fever (arenaviruses) as a public health problem.
AB  - Two "new" virus infections, Marburg and Lassa fever, now constitute diseases of
      public health importance in several countries of Africa, especially West Africa.
      Lassa fever has an insidious onset, is initially difficult to diagnose, has
      "nonspecific" clinical symptoms which have been confused with yellow fever and
      typhoid, shows evidence of persistent infection, is tremendously contagious, has
      a high mortality rate, and in particular exhibits unusual nosocomial propensity.
      It has also been shown to be the cause of premature births and spontaneous
      abortions in pregnant women. The virus is transmitted by the respiratory route
      and by direct contact with contaminated materials. Persistent complement-fixing
      antibodies have been demonstrated in patients recovered from the disease. The
      causative agent, a member of the arenavirus group, is known to be enzootic in
      rodents, especially Mastomys natalensis.

PMID- 1026323
TI  - Refractive development in strabismic children.

PMID- 1026324
TI  - A method of elicting pattern specific responses and other electro-physiological
      signals in human subjects.

PMID- 1026325
TI  - Possible effects of changes in lens pigmentation on the colour balance of an
      artist's work.

PMID- 1026326
TI  - Dominance in the visual system.

PMID- 1026327
TI  - Dominance in ocular movements.

PMID- 1026328
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on population age
      dependent responses to therapy--in vitro.

PMID- 1026329
TI  - Age-dependent survival and cell-cycle progression of cultured cells exposed to
      chemotherapeutic drugs.

PMID- 1026330
TI  - Computer simulation of leukemia therapy: combined pharmacokinetics, intracellular
      enzyme kinetics, and cell kinetics of the treatment of L1210 leukemia by cytosine
      arabinoside.
AB  - An integrated mathematic computer-based model of the pharmacokinetics,
      intracellular enzyme kinetics, and cell kinetics of the treatment of L1210
      leukemia by cytosine arabinoside (ara-C) is described. The compartment model of
      Bischoff and Dedrick is extended to the intracellular level by inclusion of
      equations describing the phosphorylation, dephosphorylation, and deamination of
      ara-C with enzymatic feedback control. The activities of kinase, deaminase, and
      phosphatase are explicitly included in the models and are estimated from relevant
      data. Cell proliferation is described by a continuous-flow mathematic model in
      which cellular maturation and cell-to-cell variability in maturation rates are
      key variables. Cell proliferation is related to intracellular biochemistry
      through mathematic expressions which relate cell lethality and progression delay
      to the time course of intracellular ara-CTP. In vitro and in vivo experiments
      performed in a number of laboratories are compared by simulation. The most
      sensitive parameters in dose-response and cell-survival simulations are
      deoxycytidine kinase activity, ara-CTP half-life, renal clearance of ara-C, and
      cell-kinetic parameters for proliferation and cell killing. Progression delay is
      vital to the realistic simulation of divided-dose schedules. By comparative
      simulation we have identified areas of uncertainty which can be classified by a
      few additional measurements. The applications of simulations combining
      pharmacokinetic, biochemical, and cell-kinetic data in vitro and in vivo are
      discussed, exploring consistency among different measurements, and relating
      experimental protocols to clinical treatment.

PMID- 1026331
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on population age
      dependent responses to therapy--in vivo.

PMID- 1026332
TI  - Size dependence of the response of Lewis lung tumors to BCNU.
AB  - The survival of Lewis lung tumor cells has been studied after a single ip dose of
      BCNU. In dissectible subcutaneous and intramuscular tumors and artificial lung
      metastases survival was measured by colony formation in soft agar and in vivo in
      the lung. The long-term control of small lung nodules by single doses of BCNU was
      studied and cell-survival estimates were inferred. The results demonstrate that
      the cytotoxic action of BCNU shows a strong dependence upon tumor size.

PMID- 1026333
TI  - Effects of surgery on the cell kinetics of residual tumor.
AB  - Noncurative excision of a primary sc Lewis lung tumor performed on Day 7 or later
      results in an increase in the thymidine index and growth rate with minimal
      changes in the cell cycle parameters of the lung metastases. The stimulation of
      the lung nodules is accompanied by a small but consistent decrease in median
      lifespan. Sham surgery performed on Day 3 or later also results in a decrease in
      median lifespan and an increase in the thymidine index of the undisturbed primary
      tumor. Artifical metastases (10(6) cells iv) are inhibited by the presence of a
      second (sc) implant and the median lifespan of the doubly implanted mice exceeds
      that of mice bearing iv implants only. In mice bearing widely metastasized Lewis
      lung carcinoma, surgery alone may have a detrimental effect on life expectancy,
      but the residual tumor foci, stimulated to more rapid growth, should be
      appropriate targets for adjuvant chemotherapy.

PMID- 1026334
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on drug lethality and
      sublethal damage: cytotoxic damage and repair.

PMID- 1026335
TI  - Effects of tumor bearing on the dynamics of host hemopoietic cells.
AB  - Hemopoietic status of the host is an important consideration in any cancer
      chemotherapy protocol. This paper examines several aspects of the response of the
      host lymphomyeloid system to tumors transplanted elsewhere: (a) characteristics
      of host leukocytes migrating into the tumor; (b) leukocyte dynamics in the marrow
      and the spleen; and (c) dynamics of hemopoietic stem cells. Repeated prelabeling
      of mice with 3HTdR prior to Ehrlich ascites tumor (EAT) transplantation indicated
      a large-scale, selective migration and/or retention of newly formed lymphocytes
      and monocytes within the tumor. Similar observations were also made in sc
      transplants of strain-specific TA-3(St) tumor. Bone marrow was found to be a
      major source of these mononuclear cells since their accumulation was suppressed
      by a prior irradiation of host marrow. Labeling with 125I-antimouse IgM, with or
      without prior incubation of cells with anti-theta serum, revealed that, within
      the 7-day-old EAT, about a third of the small lymphocytes were maturing B cells
      having readily detectable surface IgM, about a third were T cells expressing
      theta antigen, and the rest had neither marker, possible including very immature
      B cells. A high incidence of last cell category was also found in subcutaneous TA
      3(St) tumors. Ip transplantation of 10(6) EAT cells into CBA/HT6 or TA-3(St)
      cells into A/J mice caused a transient decline in femoral marrow leukocyte level
      (affecting lymphocytes most) followed by a recovery and an overshoot. In
      contrast, there was a steady rise in splenic weight or cellularity mostly
      accountable for by lymphocytes. This was partly due to local lymphoid
      proliferation and partly due to extraneous migration. Parabiosis of CBA with T6
      chromosome-bearing CBA/HT6 mice revealed that a large proportion of cells
      dividing in the spleen of the CBA host after tumor transplantation had migrated
      recently from blood. Using partial marrow chimeras (repopulated with T6
      chromosome-bearing marrow cells), bone marrow was identified as their major
      source. Furthermore, host spleens showed an increased incidence of small
      lymphocytes bearing no detectable surface-IgM nor theta antigen (possibly
      inclusive of immature B cells), and a low incidence of T cells. Tumor
      transplantation produced a rapid and substantial decline in the pleuripotent stem
      cell (CFU-S) content of the femoral marrow followed by a recovery. The converse
      was true for the CFU content of the spleen, and in addition, there was an initial
      rise in the blood CFU level, suggesting an early CFU traffic from marrow to
      spleen. A qualitatively similar pattern was also noted for stem cells committed
      to granulocyte or macrophage development as evaluated from in vitro colony
      assays. An early rise in splenic CFU level was also elicited by injecting
      sonicated tumor cells or their plasma membrane fractions, thus possibly
      indicating an antigen-driven effect. A high level of colony-stimulating activity
      (for in vitro colony growth) was found in the tumor fluid...

PMID- 1026336
TI  - In vitro responses of mammalian cells to drug-induced potentially lethal and
      sublethal damage.

PMID- 1026337
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on recruitment and
      synchrony--in vitro.

PMID- 1026338
TI  - Evidence for recruitment and synchronization in leukemia and solid tumors.
AB  - In malignant cell populations which are sensitive to drug therapy it does not
      seem necessary to potentiate treatment with perturbation of the proliferative
      characteristics. However, in some relatively drug-resistant populations
      significant advantages can be obtained by recruiting resting cells into the drug
      sensitive cell cycle. Further studies of growth-regulatory mechanisms for
      malignant cell populations may help a great deal in designing better methods of
      recruiting the resting cells back into active cell division. Synchronization of
      the dividing cells in a specificially drug-sensitive phase of the cell cycle is
      another method of potentiating chemotherapeutic effectiveness in relatively drug
      resistant cell populations. The biochemical changes induced by sequential drug
      administration may be equally important in sensitizing the malignant cell to
      subsequent drug administration.

PMID- 1026339
TI  - Synchronization with phase-specific agents in leukemia and correlation with
      clinical response to chemotherapy.
AB  - Mitotic indices, labeling indices (LI), and tritiated thymidine incorporation
      into DNA of marrow cells were conducted in patients with leukemia to determine if
      correlations existed between kinetic measurements, clinical features, and
      response to chemotherapy. Higher proliferative activity was observed in chronic
      granulocytic leukemia (CGL) and blastic phase of CGL than in acute leukemia. In
      acute myelogenous leukemia there was no correlation with various clinical
      features studied. Those patients demonstrating greater than 60% reduction in
      circulating leukemia cells within 7 days had a higher initial LI than those with
      less than 60% reduction. Cytosine arabinoside, methotrexate, and hydroxyurea were
      investigated to determine their synchronizing capability; cytosine arabinoside
      and methotrexate were superior to hydroxyurea. In a cycle-sensitive schedule
      specifically designed to synchronize cells, responses occurred more frequently in
      patients who increased thier LI 48 hours after priming doses of cytosine
      arabinoside. In an intensive-chemotherapy schedule which produced more remissions
      than the cycle-sensitive schedule, there was no relationship between initial
      kinetic measurements and response. Kinetic values increased as patients achieved
      remissions.

PMID- 1026340
TI  - Resting cells in L1210 and JB-1 ascites tumors with special emphasis on
      recycling.

PMID- 1026341
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on status of human tumor
      cell kinetics.

PMID- 1026342
TI  - Role of radioautographic studies in clinical investigative oncology and
      chemotherapy.
AB  - Three clinical areas are identified in which radioautographic studies may be of
      practical usefulness. First, human tumors can be classified according to the
      predominant pattern of DNA synthesis in the slowly proliferating cell fraction.
      This classification scheme groups carcinoma of the breast and ovary together,
      melanoma and carcinoma of the lung together, and places acute adult leukemia in a
      separate class. If there are correlations between kinetic characteristics and
      drug response behavior, this classification scheme may simplify the clinical
      study of new drugs and drug combinations. Second, changes in the labeling index
      (LI) and/or cell labeling intensity may serve as useful guides in drug
      scheduling. There are circumstances where changes in cell labeling intensity may
      be more reliable than changes in the LI. Third, cell morphology, population
      kinetics, and clinical course may all be correlated in certain human tumors,
      particularly the lymphomas. Supporting evidence in Sezary's syndrome is
      presented.

PMID- 1026343
TI  - Comparison of cell proliferation kinetics in human and experimental tumors:
      response to irradiation.
AB  - Available data on the parameters of cell kinetics in human solid tumors were
      reviewed. The mean duration of the cell cycle is 2 days; for G1 it is 1 day, for
      S it is 18 hours, and for G2 it is 6 hours. G1 has the greatest variability from
      tumor to tumor. The cell cycle and its phases are shorter in animal tumors but
      the relative durations and variabilities are similar. The labeling index (LI) and
      the growth fraction vary widely among human tumors, but they are correlated with
      the histologic type of the tumor. There is a correlation between the mean
      doubling time and the mean LI of the various histologic types of tumors. Cell
      loss is considerable in all human tumors, but it is more important in tumors with
      a high LI. Metastases and recurrence appear to have shorter doubling and cell
      cycle times than the primary tumor. There seems to be in patients with metastases
      a correlation between the survival and the growth rate of the metastases. There
      does not seem to be any correlation between the LI and the probability of
      dissemination. The depression of LI after irradiation is more important in human
      tumors than in experimental tumors and varies widely among human tumors. After
      irradiation, the depopulation seems more important in tumors with a high LI. The
      histologic groups of tumors with a high mean LI are on the average more
      radiosensitive and more sensitive to drugs.

PMID- 1026344
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on drug scheduling-
      experimental studies.

PMID- 1026345
TI  - Mathematic models of cell synchrony and drug scheduling.

PMID- 1026346
TI  - Rapid methods for utilizing cell kintics for treatment in the C3H/He spontaneous
      mammary tumor: effects of vincristine.

PMID- 1026347
TI  - Combined effect of cytosine arabinoside and thiopurines.
AB  - Dose and time survival for leukemic colony-forming units (LCFU) and normal
      hematopoietic colony-forming units (NCFU) were obtained after the administration
      of either 6-mercaptopurine (6-MP) or 6-thioguanine (TG). Survival decreased to a
      plateau level with increasing doses as expected with phase-specific agents. Time
      survival curves demonstrated increased killing of LCFU after administration of 2
      mg of 6-MP/mouse or 0.1 mg of TG/mouse reaching a minimum by 3-8 hours with
      repopulation therafter. Cytosine arabinoside (Ara-C) (1 mg/mouse) was combined
      with each agent, and the effects of sequence and interval were examined in terms
      of LCFU and NCFU survival. When Ara-C and either thiopurine were administered
      together, fractional survival was less than additive. However, as the interval
      was increased for either sequence and for both combinations, survival decreased
      to synergistic levels. Variation in dose of Ara-C and TG showed an inhibitory
      effect to be dependent upon the Ara-C dose. A correlation between results from
      the colony assay for for LCFU and survival of treated tumor-bearing mice was
      demonstrated for Ara-C plus TG. The results of these experiments are interpreted
      in terms of the proliferation kinetics of L1210 and the cellular effects of the
      agents; their clinical implications are discussed.

PMID- 1026348
TI  - Proceedings of the Symposium on Cell Kinetics and Cancer Chemotherapy (Annapolis,
      Maryland, November 4-6, 1975): Introduction to session on drug scheduling-
      clinical studies.

PMID- 1026349
TI  - Kinetic aids to proper chemotherapeutic scheduling: labeled nucleoside
      incorporation studies in vivo.

PMID- 1026350
TI  - Investigations on pharmacologic induction of partial synchronization of tumor
      cell proliferation: its relevance for cytostatic therapy.

PMID- 1026351
TI  - [Emergency valvular surgery in severe aortic insufficiency of the aorto-left
      ventricular tunnel type].

PMID- 1026352
TI  - [Vectorcardiographic analysis of ventricular septum activation in fascicular
      blocks].

PMID- 1026353
TI  - [The contractile efficiency of the left ventricle in chronic obstructive
      bronchopneumopathy].

PMID- 1026354
TI  - [Limitations of urographic examinations in the diagnostic evaluation of systemic
      arterial hypertension].

PMID- 1026355
TI  - [Study of the sphygmic periods and segmental pressure in the limbs of normal
      subjects and arteriopathic patients].

PMID- 1026356
TI  - [Myxoma cordis: considerations on 17 operated cases].

PMID- 1026357
TI  - Comprehensive view of the creative process in psychopathological art. Behavioral
      aspects in the art room.

PMID- 1026358
TI  - [The problem of death in current medicine].
AB  - The actual question of the determination of the time of death and the
      transplantation of organs have made the phenomenon of death in a special way
      important nowadays and have opened a new area of tasks, especially for the
      subject of neuropsychiatry. A reflection and discussion of the problem of death
      can only be possible in the context of actual historical and sociocultural
      developments. Regarding a fundamental reflection of the phenomenon of death in
      medicine and a physician's work, the author names especially the philosophical,
      theological, sociological, and psychological aspects of death.

PMID- 1026359
TI  - Cooperatives study of renovascular hypertension. Clinical characteristics,
      diagnostic tests and results of surgery.

PMID- 1026360
TI  - Special technics in renovascular surgery.
AB  - Apart from the critical selection of patients, surgical results in renovascular
      surgery depend mainly on technical problems. To overcome most frequent technical
      handicaps, such as a deep abdominal cavity, intervening structures, additional
      distal stenoses and limited ischemic tolerance time, several technical principles
      may be recommended. An anterior transperitoneal approach usually ensures an
      optimal exposure. The 'one-field repair' and the 'partial ex situ repair',
      include the advantage of excellent exposure and a superficial operating field.
      Particularly in cases of renal artery stenosis of the fibromuscular type, the
      routinely performed distal 'run-off control' by mechanical dilatation of the
      arterial branches, allows a high degree security. As in other fields of surgery,
      renovascular interventions should be directed to the principle of technical
      simplicity. Following this surgical concept there is only limited indication for
      the use of 'total ex situ repair' with heterotopic kidney replantation. We feel
      that this major time-consuming procedure has only a very small place in
      renovascular surgery, but a very real place in the correction of intrarenal
      lesions.

PMID- 1026361
TI  - Results of medical and surgical treatment in renovascular hypertension. Long-term
      results and choice of antihypertensive drugs.
AB  - 107 patients have been operated upon for atherosclerotic or fibromuscular renal
      artery stenosis from January 1, 1962 through December 31, 1973. At the time of
      last follow-up, or at 1 year 67% of patients with atherosclerotic renal artery
      stenosis, and 79% of patients with fibromuscular renal artery disease were
      considered to be improved. More recently 50 patients have been treated by surgery
      (24 patients) or with antihypertensive drugs. 70% (17 of 24) surgically treated
      patients and 61% (16 of 26) medically treated patients were improved after an
      average of approximately 1.5 years follow-up.

PMID- 1026362
TI  - The kidney after removal of one renal artery stenosis in the rat.

PMID- 1026363
TI  - Renovascular hypertension in children.

PMID- 1026364
TI  - Renin, renin substrate and angiotensin II concentration in renal venous blood.
AB  - In 22 hypertensive patients with unilateral renal artery stenosis (RAS) and in 8
      patients with unilateral or bilateral renal or renal arterial disease, plasma
      renin activity (PRA), renin substrate (PRS), and angiotensin II (AT II)
      concentrations were measured in both renal veins and in a peripheral vein 1-2 h
      after stimulation of renin secretion by injection of frusemide. In patients with
      elevated PRA in venous blood from a kidney with RAS, AT II was either also
      elevated, lower than or equal to PRA in peripheral blood, while the contralateral
      kidney almost invariably extracted AT II. In the 8 patients with variable renal
      diseases, the concordance between PRA and AT II measurements was better. Results
      suggest that AT II measurements in renal venous blood are less useful in
      assessing the functional significance of a RAS than those of PRA. Since PRS is
      not different in venous plasma of the diseased and the normal kidney, PRA
      measurements can be regarded as proportional to plasma renin concentration in
      this condition.

PMID- 1026365
TI  - Special patterns of renovascular hypertension.

PMID- 1026366
TI  - Pathophysiological concepts of renovascular hypertension.

PMID- 1026367
TI  - Relevant diagnostic procedures in renovascular hypertension.
AB  - The validity of invasive preoperative diagnostic procedures in patients with
      unilateral renovascular hypertension was assessed. A significant lowering of
      blood pressure following reconstructive surgery can be predicted if following
      stimulation with Dihydralazine the renal-venous renin ratio of the involved to
      the noninvolved kidney is at least 2.0. Furthermore, it is of importance to
      determine the renal perfusion rate in the contralateral non-stenotic kidney which
      should be within normal limits. If these two criteria are met then in the
      majority of cases surgical intervention in unilateral hypertension is meaningful.

PMID- 1026368
TI  - Renin activity, renin secretion rate and renal hemodynamics as functional tests
      renovascular hypertension.

PMID- 1026369
TI  - Measurement of plasma renin concentration and angiotensin II in peripheral and
      renal venous plasma in the management of renovascular hypertension.
AB  - Athough in general, measurement of renal vein renin appears to give a good
      prediction as to the subsequent response to surgery, its main value lies in its
      ability to reflect changes in renal plasma flow; true changes in renin secretion
      rate being much more difficult to detect. Although it is a little early to say
      how much information can be derived from saralasin infusions, caution must be
      exercised in necessarily assuming that the test accurately reflects subsequent
      surgical response.

PMID- 1026370
TI  - Saralasin (1-sar-8-ala-angiotensin II): pharmacology and clinical use in
      angiotensin-dependent hypertension.

PMID- 1026371
TI  - Angiographic aspects of renovascular hypertension.
AB  - Angiography is the most important diagnostic procedure for evaluation of
      renovascular hypertension. Technique and limits of this method as well as
      possible ways of improving its diagnostic value are discussed. The pathogenetic
      significance of a renal artery stenosis in hypertension and the prognosis for a
      vascular surgical intervention is discussed in the light of bilateral renin
      determination and the 138 Xe method of measuring intrarenal hemodynamics.

PMID- 1026372
TI  - Pathology of renovascular hypertension.

PMID- 1026373
TI  - Extracorporeal renal surgery for renovascular hypertension.
AB  - Nine cases of renovascular hypertension caused either by lesions in the distal
      part of the renal artery or by proximal renal atery stenosis where local
      reconstruction was considered dangerous were treated by extracorporeal
      reconstructive surgery and autotransplantation. The kidney were removed, cooled
      and preserved by simple hypothermia during workbench reconstruction on a separate
      side table. After reconstruction the kidneys were reimplanted to the groin. One
      kidney was lost due to infection and bleeding. All patients were preoperatively
      severely hypertensive. Blood pressure was normalized in all cases but one with a
      homotransplanted kidney which also was undergoing chronic rejection. The method
      is simple and safe and offers new possibilities to treat lesions in the kidney
      which previously were impossible or very risky to treat surgically. It is a safe
      alternative to conventional methods in case of anatomical structures making local
      reconstruction difficult.

PMID- 1026374
TI  - Active infective endocarditis: a clinicopathologic analysis of 137 necropsy
      patients.

PMID- 1026375
TI  - Polyploidization in rat liver: the role of binucleate cells.
AB  - Liver cells were isolated from rats undergoing active formation of tetraploid
      cells and prelabelled in their DNA with 14C thymidine. Autoradiography of the
      isolated cells showed that binucleate diploid cells, a major component of the
      parenchymal cell population at this time, are also active in DNA synthesis. These
      cells probably pass through mitosis and generate mononucleate tetraploid cells,
      the dominant cell type of mature rat liver, since the frequency of binucleate
      tetraploid cells is very low at this stage in rat liver development. The
      biological significance of liver polyploidy is discussed and it is suggested that
      this lies in enhanced resistance to mutagenesis.

PMID- 1026376
TI  - Transcriptional and post-transcriptional control of rRNA synthesis in human liver
      cells cultured in presence of L-triiodothyronine.
AB  - The synthesis of rRNA in cultured human liver cells grown in the presence of L
      triiodothyronine (1.6 x 10(-5)M) was measured by means of polyacrylamide gel
      electrophoresis using a double labelling technique. The rate of accumulation of
      rRNA in the cytoplasm as well as the turnover of rRNA in ribosomes remained
      unchanged in comparison to control cells regardless of growth stage or cell
      population density. L-triiodothyronine, however, induced an increased synthesis
      of rpreRNA when added in the early growth phase of sparse cultures. This
      induction was time dependent and occurred temporarily, but it was never followed
      by a similar accumulation of mature rRNA. Therefore, in this system two control
      mechanisms counteracting each other were effective: the increased rpreRNA
      synthesis indicates a transcriptional control, and the wastage of odd rpreRNA,
      however, a post-transcriptional control.

PMID- 1026377
TI  - Shape changes and reduced calcium level in the surface membrane region of human
      platelets exposed to manganese in vitro.
AB  - The effect of exogenous manganese ions upon human platelets in vitro has been
      studied. Morphological changes reported include the loss of discoid shape,
      increase in filopodia and close apposition of platelet surfaces. Electron
      microscope X-ray microanalysis of thin-sectioned material revealed a significant
      decrease in the bound calcium levels of the surface membrane as a result of
      manganese treatment. Analysis of whole platelet homogenates using atomic
      absorption spectrophotometry indicated that the total internal platelet calcium
      content had increased significantly. It is suggested that manganese induces the
      observed changes by displacing calcium from the regulatory system of an
      actomyosin-like protein complex at the periphery of the platelet.

PMID- 1026378
TI  - Endoscopy in experimental urology using an argon-laser beam.
AB  - For the first time cystoscopic argon and neodymium-YAG laser irradiation of the
      bladder wall using a flexible quartz fiber light guide (as described by Nath) was
      studied morphologically and histologically. It was seen that it is possible to
      control the depth of tissue removal without the risk of perforation of the
      bladder wall. Therefore endoscopic surgery of bladder tumors by laser radiation
      seems to be possible. Hydronephrosis could not be observed even after direct
      laser irradiation of the orifices.

PMID- 1026379
TI  - [Intestinal placement of Miller-Abbott-tubes under endoscopic guidance (author's
      transl)].
AB  - Based on experiences with 9 treatments in 7 cases of intestinal obstruction, the
      technique of endoscopic transgastric guidance of Miller-Abbott-tubes is reported.
      On our service, the above mentioned method was applied in the treatment of
      intestinal obstruction observed in cases of advanced malignant lesions as well as
      in patients with intestinal obstruction in the early postoperative period.
      Apparative aids and technical guidelines are accentuated. The method requires a
      team consisting of at least one physician and three assistents with clearly
      defined competence. Success also depends on the selection of material used.
      Special problems arise in the treatment of patients following partial
      gastrectomy. Routine X-rays are important in order to control the course of
      treatment and to documentate the result. The inclusion of endoscopic aids
      resulted in successful intestinal intubation in all cases treated. The
      utilization of recommended guidelines seemingly rules out technical failure in
      the attempt of placing the tube in the desired anatomic position.

PMID- 1026380
TI  - Colonoscopic perforation: its emergency treatment.
AB  - One of the accepted complications of colonoscopy is perforation. This is known to
      occur in greater frequency in patients having undergone previous pelvic or
      colonic surgery, as well as patients suffering from diverticulosis. A case is
      presented of colonic perforation during diagnostic examination in an area of
      adhesions secondary to pelvic surgery. Immediately after the perforation, the
      patient entered into vascular collapse and respiratory distress, with a distended
      abdomen. The introduction of a large bore intravenous catheter into the abdominal
      cavity with the release of the pneumoperitoneum resulted in an instantaneous
      return of vital signs and the patient subsequently underwent surgery and
      recovered. It is felt that this method of emergency treatment can be life-saving
      in a patient perforating during colonoscopy.

PMID- 1026381
TI  - Color and transmittance of human amniotic membranes.

PMID- 1026382
TI  - Manometric studies during ERCP and endoscopic papillotomy.

PMID- 1026383
TI  - An improved flexible cholangioscope.

PMID- 1026384
TI  - The endoscopic demonstration of coeliac disease.
AB  - The first part of the duodenum has been studied endoscopically in treated and
      untreated coeliac patients. Biopsies taken from the duodenal cap during
      endoscopic examination, show villous atrophy similar to that found in the distal
      duodenum and jejunum. Using the indigocarmine scattering method, severe atrophy
      of the mucosal surface can be demonstrated throughout the duodenal cap, in vivo,
      in untreated coeliac disease.

PMID- 1026385
TI  - Technique, indication and evidence of sinuscopy.
AB  - It is reported on experiences made with endoscopy of the maxillary sinus by means
      of three different angular optics according to Hopkins (0 degree, 30 degrees, 70
      degrees). A sinuscopy is indicated in order to obtain an early diagnosis of
      malignant tumour growth; it is decisive as to an operation of the maxillary sinus
      to be carried out; it clarifies clinically uncertain maxillary sinus findings. In
      addition to the usual investigation methods, the sinuscopy allows a direct local
      diagnosis. Moreover, diagnostic and therapeutic operations may be carried out by
      means of a biopsy forceps.

PMID- 1026386
TI  - Results of diagnostic pelviscopy in cases of chronic recurrent pelvic disease.
AB  - During the last two years we have performed diagnostic pelviscopy in 90 patients
      suffering from a syndrome of chronic repeated pelvic disease. In 44 patients
      extragenital endometriosis was diagnosed as the causing factor. In 15 cases we
      found wide-spread adhesions in the region of the lower pelvis after preceeding
      laparotomies. Only in 12 patients pelvic-alterations caused by chronic
      inflammatory processes of the adnexa with peritubal adhesions were discovered. As
      these results show extragenital endometriosis represents in far more cases as
      generally believed the cause of gynecological pains. We want to give special
      emphasis to the diagnosis and treatment of this disease.

PMID- 1026387
TI  - Removal of foreign bodies from subsegmental bronchi with the fiberbronchoscope.
AB  - Though the fiberbronchoscope has been designed for diagnostic purposes, it can be
      used, as well, for the removal of small foreign bodies from segmental and
      subsegmental bronchi; In this paper we report two cases in which we successfully
      removed from subsegmental bronchi a pulp-canal reamer and a melon seed. This fact
      proves that in some of these cases we can avoid thoracotomies.

PMID- 1026388
TI  - A new device for endoscopic foreign body extraction.
AB  - A yoghurt-spoon with a long handle which could not be removed initially from the
      stomach during several sessions was finally successfully extracted by a new
      simple device.

PMID- 1026389
TI  - A new self-twisting polypectomy snare.
AB  - In contrast to the hitherto available polypectomy snares the newly designed snare
      for endoscopic polypectomy offers the following advantages: when the tip of the
      endoscope is directed towards the polyp the snare turns automatically into a
      position parallel to the polyp-bearing bowel wall. "Combusting ulcers" are
      avoided, a homogenous circular flow of electric current is guaranteed.

PMID- 1026390
TI  - Transgastroscopic ultrasonography.
AB  - A newly designed ultrasonography probe is presented which can be advanced through
      the instrumentation channel of an operative endoscope (TGF-Olympus). The A-scan
      allows the differentiation between solid and cystic masses in the upper abdomen
      leading to gastric impression. Guided puncture of pancreatic pseudocysts is based
      on a solid diagnosis and can be performed from the gastric lumen thus avoiding
      the development of pancreato-cutaneous fistulas.

PMID- 1026391
TI  - Oesophagus bezoar diagnosed and removed endoscopically.
AB  - The authors describe the rare case of bezoar in the oesophagus. Their patient was
      sent to their Clinics with a diagnosed oesophageal tumor. The exact diagnosis was
      established by endoscopical examination. The bezoar was removed by endoscope,
      therefore, an operation was not necessary.

PMID- 1026392
TI  - Double pylorus and esophageal achalasia.
AB  - 29 cases of double pylorus have been reported so far. It is thought that in 85%
      of the cases it has been due to a fistulous gastro-duodenal ulcer and the
      remaining 15% would be of a congenital origin. In the case we have reported the
      double pylorus is believed to be a congenital anomaly associated with a mega
      esophagus of similar etiology.

PMID- 1026393
TI  - A case of common bile duct ascariasis diagnosed by duodenoscopy.
AB  - A case of common bile duct ascariasis diagnosed by duodenoscopy is presented. At
      the admission, the patient, cholecystectomized for gallstones 13 years before,
      had been complaining of epigastric pain associated with post-prandial and
      nocturnal vomiting. Physical examination showed only slight tenderness in the
      epigastrium. Laboratory findings were within normal limits, with the exception of
      a moderate leukocytosis. Intravenous cholangiography showed the lack of
      visualization of the terminal common bile duct, but the flow of contrast medium
      was normal. Duodenoscopy, carried out without a specific clinical suspicion,
      revealed an ascaris lumbricoides inserted in the common bile duct and partially
      protruding from the papilla Vateri. The patient was treated by piperazine,
      intravenous fluids, antibiotics and a choleretic compound. After 24 hours an
      ascaris 33 cm long was excreted in the faeces and the patient became symptom
      free. Some pathophysiological, clinical and epidemiological aspects of biliary
      ascariasis are discussed.

PMID- 1026394
TI  - Hypogammaglobulinemia with lymphoid nodular hyperplasia of the small bowel:
      endoscopic diagnosis of one case.
AB  - A 37-year-old man suffering from abdominal pain and diarrhea, was hospitalized
      because of abdominal discomfort. Gastroduodenal series showed multiple duodenal
      filling defects. Gastroduodenoscopic examination revealed numerous nodular
      lesions in the duodenum and biopsy specimen demonstrated nodular lymphoid
      hyperplasia. The serum immunoelectrophoretic pattern showed a virtual absence of
      IgA and IgM and a very decreased level of IgG. To our knowledge, it is the first
      case of hypogammaglobulinaemia with nodular hyperplasia of the small bowel,
      diagnosed by endoscopy and forceps biopsy.

PMID- 1026395
TI  - Proceedings of the WHO-NIEHS conference on potential environmental health hazards
      from technological developments in rubber and plastics industries. Research
      Triangle Park, N.C., March 1-3, 1976: Introductory statement.

PMID- 1026396
TI  - Measurement of some potentially hazardous materials in the atmosphere of rubber
      factories.
AB  - Two separate topics of work are outlined: methods for the measurement of
      chlorinated monomers in PVC and polychloroprene, and also methods for the
      measurement of these materials in factory air. Typical results which have been
      obtained in supplies of raw materials, in finished products, and in the working
      atmosphere at manufacturing operations are given. The second topic concerns the
      measurement of benzo[a]pyrene in the atmosphere of a tire manufacturing plant.
      This material is present in trace quantities in the mineral oils and carbon
      blacks used by the industry. The atmospheric concentrations present at various
      processes in this plant were measured on a daily basis over a period of two
      years, and the results obtained compared with results taken concurrently from an
      outside air station. It is shown that no significant quantities of benzo[a]pyrene
      are produced by tire manufacturing operations.

PMID- 1026397
TI  - Quantitative analysis of styrene monomer in polystyrene and foods including some
      preliminary studies of the uptake and pharmacodynamics of the monomer in rats.
AB  - A variety of food containers, drinking cups and cutlery, fabricated from
      polystyrene (PS) or polystyrene-related plastic, were analyzed for their styrene
      monomer content. Samples of yogurt, packaged in PS cups, were similarly analyzed
      and the leaching of styrene monomer from PS containers by some food simulants was
      also determined. Blood level studies with rats, dosed with styrene monomer by
      various routes, illustrated uptake phenomena that were dependent on the dose and
      route of administration and were also affected by the vehicle used to convey the
      styrene monomer.

PMID- 1026398
TI  - Chronic diseases in the rubber industry.
AB  - An overview is presented of epidemiologic studies of chronic diseases in the
      rubber industry. Analyses of the mortality experience during the period 1964-1972
      of workers age 40-64 and retirees age 65-84 of two large rubber and tire
      manufacturing companies consistently disclosed excesses of deaths attributed to
      leukemia and lymphosarcoma, and for cancers of the stomach, large intestine, and
      prostate. The relation of site-specific malignancies to work histories and
      grouped occupational titles as surrogate measures of work-related exposures to
      possible carcinogens is described. There was no evidence of company-wide,
      sizable, consistent excess for the other major chronic diseases causes of death.
      Although a total cohort deficit in the mortality rate for lung cancer was found,
      there was a history of increased frequency of exposure to certain work areas
      among lung cancer decedents. Morbidity studies, including analysis of disability
      retirements, and ad hoc questionnaire and health testing surveys, disclosed
      excesses of chronic pulmonary diseases. There was evidence of an interactive
      effect in the association of work and smoking histories with pulmonary disability
      retirement.

PMID- 1026399
TI  - Hepatic and extrahepatic metabolism of 14C-styrene oxide.
AB  - With 8-(14)C-styrene oxide as substrate, specific glutathione S-transferase and
      epoxide hydrase activities were determined in subcellular fractions of liver,
      lungs, kidney, and intestinal mucosa from rabbit, rat, and guinea pig. Liver had
      the highest enzyme activities in each species. Rat and guinea pig had higher
      glutathione S-transferase activity in both liver and kidney than rabbit. Rat
      testis also had appreciable glutathione S-transferase activity. The perinatal
      development of epoxide hydrase and glutathione S-transferase was followed in
      liver and several extrahepatic tissues of fetal and neonatal guinea pigs and
      rabbits. The rates at which enzyme activities reached adult levels in the
      extrahepatic tissues differed from the liver in both species. Epoxide hydrase and
      glutathione S-transferases developed at different rates in each organ,
      demonstrating that the relative importance of these two detoxifying pathways for
      styrene oxide may shift before and after birth. The effects of pretreating male
      and female rats with phenobarbital (PB), 1,2,3,4-dibenzanthracene (DBA),
      pregnenolone-16alpha-carbonitrile (PCN), or 2,3,7,8-tetrachlorodibenzo-p-dioxin
      (TCDD) on hepatic and extrahepatic epoxide hydrase and glutathione S-transferase
      activities toward styrene oxide were determined. PB increased both enzyme
      activities in liver of both sexes. PCN induced only glutathione S-transferase
      activity in female liver. Extrahepatic epoxide hydrase and glutathione S
      transferase activities were unaffected except that TCDD doubled female renal
      epoxide hydrase activity and PB increased intestinal epoxide hydrase activity in
      both sexes. Styrene oxide biotransformation was studied in isolated, perfused rat
      liver and rabbit lung preparations. Conjugation with glutathione was a major
      metabolic pathway although significant amounts of diol were also formed in each
      instance. In rat liver, 27-40% of the administered styrene oxide was excreted via
      the bile mainly as S-(1-phenyl-2-hydroxyethyl)glutathione.

PMID- 1026400
TI  - Dose-dependent fate of vinyl chloride and its possible relationship to
      oncogenicity in rats.
AB  - Studies on the fate of 14C-labeled vinyl chloride (VC) following oral
      administration and inhalation exposure in rats demonstrated that the disposition
      of VC in the body is a function of the dose. More importantly, from the data
      available, it appears that a correlation exists between doses of VC which cause
      tumors and those that saturate metabolic or detoxifying pathways. Additional
      studies characterized the depression of liver non-protein sulfhydryl content
      (primarily GSH) with the duration and concentration of exposure to VC. The
      results of these investigations indicate that statistical projections utilizing
      data collected from rats exposed to high doses of VC are invalid for predicting
      the hazard of low level exposure, because such projections violate a priori
      assumption that the dynamics governing the fate of VC in the body are unaltered.

PMID- 1026401
TI  - Demographic variation in cancer in relation to industrial and environmental
      influence.
AB  - Mortality data (183,064 deaths in a 30-year period, 1940-1969) by sex and three
      ethnic groups (white excluding Spanish-surnamed, nonwhite, and Spanish-surnamed)
      in 15 regions within the city (Houston), grouped around the air pollution sample
      collection stations have been analyzed. Valid contrast studies were possible in
      only one region within the city for all three groups and in six regions for white
      excluding Spanish-surnamed and nonwhite. There is evidence that the environmental
      factors of exposure over time to air and industrial pollutants in Houston has had
      a demonstrable effect in increasing regional mortality from cancer of the
      respiratory tract as well as from all other diseases and conditions of the
      respiratory tract and heart disease. This study points out the need for mutually
      sustained collaboration of effort of the scientific and industrial communities to
      redirect their attention and research efforts to the exploration of the
      carcinogenic potential of the microchemical environment.

PMID- 1026402
TI  - Mortality and cancer morbidity in a group of Swedish VCM and PCV production
      workers.
AB  - The cohort of workers employed in a Swedish vinyl chloride/poly(vinyl chloride)
      plant since its start in the early 1940's has been followed for mortality and
      cancer morbidity patterns. Only 21 of the 771 persons could not be traced.
      Difficulties in establishing exposure levels at different work areas in the past
      makes an evaluation of dose-effect relationships impossible. A four- to fivefold
      excess of pancreas/liver tumors was found, including two cases later classified
      as angiosarcomas of the liver. The number of brain tumors and suicide do not
      deviate significantly from expected. Cardiovascular and cerebrovascular diseases,
      on the other hand, differ significantly from the expected. The discrepancies
      between previous reports on VCM/PVC workers and this report are discussed. The
      possible etiology of the cardiovascular deaths is also discussed.

PMID- 1026403
TI  - Clinical studies of styrene workers: initial findings.
AB  - Styrene monomer is a high volume chemical used chiefly in production of
      polystyrene. A clinical survey of 493 production workers was undertaken at the
      oldest and largest monomer production, polymerization, and extrusion facility in
      the U.S. Relative exposure durations and levels were obtained from occupational
      histories. Significant differences between the high and low exposure groups were
      found with regard to history of acute prenarcotic symptoms, acute lower
      respiratory symptoms, prevalence of FEV 1/FV less than 75 per cent, and elevated
      GCTP. Other liver function tests, chest x-ray, FVC less than 80 per cent, and
      hematological parameters showed no distinct pattern. A concomitant mortality
      study has been mounted and is in progress.

PMID- 1026404
TI  - Malignant tumors of the liver and lungs in an area with a PVC industry.
AB  - The incidence of malignant tumors of the lung and bronchus and of cytologically
      confirmed primary malignant tumor of the liver was analyzed for a 4-yr period in
      a city with several factories, including a PVC industry. Prior to the study two
      cases of angio-sarcoma of the liver were diagnosed in workers employed in PVC
      production. The total incidence of analyzed tumors was only slightly higher than
      predicted. The tumors of the liver recorded did not show any dependence on place
      of work or residence. During the period of observation, malignant tumors of the
      bronchus (lung) were not recorded in the PVC industry. Their rate in the area in
      which the PVC industry is situated was approximately the same as that for the
      entire city area. The study does not indicate that the occurrence of malignant
      tumors other than angiosarcoma is associated with exposure to vinyl chloride.

PMID- 1026405
TI  - Health hazards in the production and processing of some fibers, resins, and
      plastics in Bulgaria.
AB  - Results of the toxicological studies of working conditions, general and
      professional morbidity, and complex examinations carried out on workers engaged
      in the production of polyamides, polyacrylonitrile fibers, polyester fibers and
      poly (vinyl chloride) resin, urea-formaldehyde glue, glass fibre materials and
      polyurethane resins are given. An extremely high occupational hazard for workers
      in the production of poly (vinyl chloride) resin and porous materials from
      polyurethane resins and urea-formaldehyde glue has been established. Cases of
      vinyl chloride disease, poisoning from formaldehyde, isocyanates, and styrene
      were noted. Prophylactic measures were taken in Bulgaria to lessen the
      occupational hazard in the productions as set forth included limitation of the
      work day to 6 hr, free food, additional bonus and leave, and annual physical
      examinations of workers.

PMID- 1026406
TI  - Recent progress in safety evaluation studies on plasticizers and plastics and
      their controlled use in Japan.
AB  - Recent experimental studies in Japan on the evaluation of potential health
      hazards from phthalate esters used in manufacturing poly (vinyl chloride) as well
      as several plastics for medical devices and for food containers and packages were
      introduced. Development of pulmonary granuloma formation after intravenous
      injection of diethylhexyl phthalate was assumed to be dependent on the particle
      size of the phthalate in vehicle used. Dietary administration of large amount of
      diethylhexyl phthalate and dibutyl phthalate produced renal cysts in mothers and
      in descendants in reproduction studies in mice. Cytotoxicity and mutagenicity of
      the phthalates and several plastics and resins were also examined by in vivo and
      in vitro studies. Hematological parameters examined in rabbits after repeated
      intravenous injection of diethylhexyl phthalate and after implantation of
      plastics in aorta for 3--6 months did not show any significant change. A slow
      decrease of radioactivity was observed in adipose tissue of rats following oral
      administration of 14C-labeled diethylhexyl phthalate. tthe administrative action
      on phthalates by the Japanese Ministry of Health and Welfare is briefly reviewed.

PMID- 1026407
TI  - Problems and perspective in epidemiological study of occupational health hazards
      in the rubber industry.
AB  - An epidemiological analysis of the problems in the study of companies engaged in
      the manufacture of rubber products in different countries and in different time
      periods is given. Selected findings on cancer of gallbladder and biliary system,
      cancer of the lung, and tumors of the central nervous system among rubber workers
      are presented.

PMID- 1026408
TI  - Studies on the metabolism of vinyl chloride.
AB  - Vinyl chloride (VCM) is not carcinogenic by itself, it is bioactivated to the
      highly reactive alkylating oxirane chloroethylene oxide. Further metabolism,
      apparently, leads via an interaction of the primary alkylating metabolites with
      glutathion to S-(2-carboxy-methyl)-cysteine and thiodiacetic acid which are
      eliminated with the urine. Up to now, it has not been ascertained whether the
      oxirane alone is the essential carcinogenic factor or whether other metabolites
      are also involved in carcinogenicity. Likewise, it is still unknown whether the
      metabolites excreted in the urine might be used as biological criteria for
      exposure to VCM, because these metabolites probably can originate from a series
      of substances other than VCM. This problem could stimulate investigations on the
      possible carcinogenic activity of these substances.

PMID- 1026409
TI  - Consumer hazards of plastics.
AB  - The modern consumer is exposed to a wide variety of plastic and rubber products
      in his day to day life: at home, work, school, shopping, recreation and play, and
      transport. A large variety of toxic sequellae have resulted from untoward
      exposures by many different routes: oral, dermal, inhalation, and parenteral.
      Toxic change may result from the plastic itself, migration of unbound components
      and additives, chemical decomposition or toxic pyrolysis products. The type of
      damage may involve acute poisoning, chronic organ damage, reproductive disorders,
      and carcinogenic, mutagenic and teratogenic episodes. Typical examples for all
      routes are cited along with the activites of Canadian regulatory agencies to
      reduce both the incidence and severity of plastic-induced disease.

PMID- 1026410
TI  - Diffusion of residual monomer in polymer resins.
AB  - A simplified mathematical model which made use of Fick's laws of diffusion
      written in spherical coordinates was developed to describe the rate of diffusion
      of residual monomers from polymer resins. The properties of the monomer-polymer
      system which influenced the amount of monomer remaining in the polymer as a
      function of time were the diffusivity and solubility of the monomer in the
      polymer, and the particle size of the polymer resin. This model was used to
      analyze literature data on the diffusion of residual vinyl chloride monomer in
      polyvinyl chloride resins made by the suspension process. It was concluded that
      particle size of the resin was a significant parameter which should be taken
      advantage of in process equipment designed to remove residual monomer from PVC
      resins. The diffusivity of the monomer in the polymer was a function of the
      solubility of the monomer in the polymer. Monomer solubility can be determined
      from Henry's law. It was suggested that this model could be adapted to describe
      diffusion of monomers from any monomer-polymer system, and would be a useful
      approach to modeling the transport of nonreactive chemical additives from
      plastics.

PMID- 1026411
TI  - Recent achievements and research initiated in the Swedish plastics and rubber
      industry.
AB  - The improvement in exposure conditions in the Swedish vinyl chloride producing
      industry is reported. The article comments on the technology and control methods
      by which the vinyl chloride concentration has been lowered to less than 1 ppm
      vinyl chloride. Two epidemiological retrospective cohort studies are presently
      under way on workers in PVC-utilizing industries and in the rubber industry.

PMID- 1026412
TI  - Criteria for the health evaluation of polymeric materials building.
AB  - Various polymer-based synthetic materials have become increasingly ubiquitous in
      manufactured materials in the U.S.S.R. These release various chemical compounds
      to the ambient air. The maximum permissible concentrations that have been
      established for various hazardous chemicals in ambient air must be adjusted to
      account for the conditions of apartment life. Studies have been conducted to
      determine exactly what compounds are released and at what rate. Toxicological
      studies and studies of various physical and chemical properties are required to
      determine the health effects of these chemicals at concentrations at which they
      are expected to occur in apartments. More research has to be carried out in this
      field to further expand our knowledge, and we must beware of any introduction of
      new polymeric materials without first studying their contribution to possible
      detrimental health effects.

PMID- 1026413
TI  - Difficulties of forecasting health implications.

PMID- 1026414
TI  - Proceedings of the WHO-NIEHS conference on potential environmental health hazards
      from technological developments in rubber and plastics industries. Research
      Triangle Park, N.C., March 1-3, 1976: Concluding remarks.

PMID- 1026415
TI  - Occupational disease in the rubber industry.
AB  - We have studied mortality patterns in a large cohort of rubber workers. We have
      examined workers exposed to curing fumes, processing dusts, and industrial talc
      and have begun to evaluate exposures of these workers in detail. Gastrointestinal
      (especially stomach) cancer appears in excess in processing workers. Lung cancer
      is excessive in curing workers. Leukemia is increased generally. All three groups
      studied for respiratory disease have an increase in disease prevalence which is
      related to intensity and duration of exposure. Since both an increase in stomach
      cancer and respiratory disease is seen in processing workers, exposures in this
      area must be controlled. Since both lung cancer and chronic respiratory disease
      is excessive in curing rooms, this exposure must be controlled. The leukemia risk
      is probably related to solvents. Whether this is all explainable by past benzene
      exposure is unknown. Further studies are planned to refine our knowledge
      concerning these risks so that occupational disease in the rubber industry can be
      prevented.

PMID- 1026416
TI  - Neurotoxicity and behavioral effects of thiram in rats.
AB  - Eight of 24 female rats fed 66.9 mg/kg-day of thiram developed neurotoxicity. The
      neurotoxic effects were characterized by ataxia and paralysis of the hind legs.
      There were demyelination, degeneration of the axis cylinders, and presence of
      macrophages in the nerve bundle of the sciatic nerve. Degeneration in the ventral
      horn of the lower lumbar region of the spinal cord was evidenced by chromatolysis
      of motorneurons, pyknosis, and satellitosis. During a second experiment, 4 of 24
      females fed 65.8 mg/kg--day also developed ataxia and paralysis. An additional 9
      females showed clasping of the hind feet when picked up by the tail. Nerve
      conduction could not be measured for one severely ataxic rat and the
      electromyogram indicated a loss of motor unit function. Histopathology of this
      rat, along with the others, suggests the peripheral nerve as the primary site of
      the lesion. Thiram also caused behavioral changes in apparently normal rats. The
      walking pattern of the hind legs was altered with decreases in stride width and
      the angle between contralateral steps. These rats required significantly more
      shock-motivations and cleared a lower height in a jump/climb ability test. An
      open-field study indicated that thiram caused hyperactivity in the nonataxic rats
      of both sexes. Three of 24 rats fed 95.8 mg/kg-day of ferbam also developed
      ataxia or paralysis.

PMID- 1026417
TI  - Health aspects of the curing of synthetic rubbers.
AB  - A commonly used tread rubber formulation was cured in the laboratory under
      conditions simulating vulcanization in the Bag-O-Matic press. Volatile emissions
      were collected on charcoal and analyzed by combined GC-mass spectrometry. The
      compounds identified were either contaminants present in the raw material or
      reaction products. Some of these compounds were also identified in charcoal tube
      samples collected in the atmosphere of the industrial operations. Estimates based
      on the loss of weight of rubber during curing were used to predict airborne
      concentrations and compared to the concentrations actually found. The literature
      of the toxicity of raw materials and effluents was reviewed, and no acute or
      chronic toxicological effects would be anticipated. Information concerning
      potential carcinogenicity was not available and could not be evaluated.

PMID- 1026418
TI  - Priorities in the investigation of human health hazards in the plastics and
      synthetic rubber industries.
AB  - Experiences in the past decade provide guidance in selecting priorities for
      investigation of health hazards in chemical industries. Pride of place should be
      given to the experience of large industrial populations, in part simply because
      large numbers of people are at risk and in part because such studies are more
      likely to give reliable answers. This recommendation has further strength when
      there is community exposure as well. Parenthetically, large populations provide
      opportunity to study multiple factor interaction; without this, toxic potential
      of a single agent may be obscured. Second, investigations should be mounted when
      there is reason for suspicion, as with particular chemical configurations,
      observed organ toxicity, animal carcinogenicity, unusual clinical experience
      ("signal" tumors). It may be added that when agents have already been used
      several decades, evaluation of human experience with them is now in order, if
      only to document absence of toxicity. The same recommendations hold for planned
      introduction of new agents or widened distribution of existing ones, until we
      have better information concerning validity of "pretesting" programs. Major
      advances have been made in epidemiological methods for these investigations.
      These now allow us to successfully focus on small defined groups as well as to
      manage large populations.

PMID- 1026419
TI  - Chemistry and toxicity of flame retardants for plastics.
AB  - An overview of commercially used flame retardants is give. The most used flame
      retardants are illustrated and the seven major markets, which use 96% of all
      flame-retarded polymers, are described. Annual flame retardant growth rate for
      each major market is also projected. Toxicity data are reviewed on only those
      compositions that are considered commercially significant today. This includes 18
      compounds or families of compounds and four inherently flame-retarded polymers.
      Toxicological studies of flame retardants for most synthetic materials are of
      recent origin and only a few of the compounds have been evaluated in any great
      detail. Considerable toxicological problems may exist in the manufacturing of
      some flame retardants, their by-products, and possible decomposition products.

PMID- 1026420
TI  - Toxicity of combustion products from burning polymers: development and evaluation
      of methods.
AB  - Laboratory and room-scale experiments were conducted with natural and synthetic
      polymers: cotton, paper, wood, wool, acetate, acrylic, nylon, and urethane. Smoke
      and off-gases from single materials were generated in a dual-compartment 110
      liter exposure chamber. Multicomponent, composite fuel loads were burned within a
      100 m(3) facility subdivided into rooms. In chamber experiments, mortality
      depended on the amount of material burned, i.e., fuel consumption (FC).
      Conventional dose (FC)/mortality curves were obtained, and the amount of fuel
      required to produce 50% mortality (FC(50)) was calculated. With simple flame
      ignition, cotton was the only material that produced smoke concentrations lethal
      to rats; FC(50) values for cotton ranged from 2 g to 9 g, depending on the
      configuration of the cotton sample burned. When supplemental conductive heat was
      added to flame ignition, the following FC(50) values were obtained; nylon, 7 g;
      acrylic, 8 g; newsprint, 9 g; cotton, 10 g; and wood, 11 g. Mortality resulting
      from any given material depended upon the specific conditions employed for its
      thermal decomposition. Toxicity of off-gasses from pyrolysis of phosphorus
      containing trimethylol propane-polyurethane foams was markedly decreased by
      addition of a flame ignition source. Further studies are needed to determine the
      possible relevance of single-material laboratory scale smoke toxicity
      experiments. Room-scale burns were conducted to assess the relative contributions
      of single materials to toxicity of smoke produced by a multicomponent self
      perpetuating fire. Preliminary results suggest that this approach permits a
      realistic evaluation of the contribution of single materials to the toxicity of
      smoke from residential fires.

PMID- 1026421
TI  - Non-pulmonary tuberculosis in Ethiopian medical in-patients.

PMID- 1026422
TI  - Management of sigmoid  volvulus with special reference to primary resection.

PMID- 1026423
TI  - A comparative trial of the use of fish protein concentrate and cow milk proteins
      in the treatment of kwashiorkor.

PMID- 1026424
TI  - Intestinal parasitism in fifty communities on the central plateau of Ethiopia.

PMID- 1026425
TI  - Neonatal septicaemia.

PMID- 1026426
TI  - Congenital hypertrophic pyloric stenosis in Ethiopian infants.

PMID- 1026427
TI  - Is elephantiasis on the lower legs a geochemical disease?

PMID- 1026428
TI  - Isolation and biochemical properties of toxic tryptic peptides of ricinotoxin
      from Ricinus communis seeds.
AB  - Tryptic hydrolysis conditions of ricinotoxin were studied in order to produce not
      only digestion of this glycoprotein but also still toxic tryptic peptides. No
      hydrolysis was obtained without prior denaturation. The best conditions of
      denaturation were obtained with 0.2 M guanidine hydrochloride and, to a lower
      extent, by heat treatment at 90 degrees C during 6 minutes. The hydrolysates were
      fractionated on Sephadex G100 column. In each case highly toxic peptide fractions
      were obtained which showed, like native ricinotoxin, a strong inhibitory action
      on the in vitro protein synthesis ina cell-free eukaryotic system but were
      without any action on a prokaryotic cell-free system.

PMID- 1026429
TI  - [Absorption of diethylstilbestrol (DES) by plants. Dangers of using manure of
      animals treated with DES].
AB  - Diethylstilboestrol, an anabolist used per os or in sub-cutaneous implants in a
      number of countries, but not in France, on animals of the  bovine species, is
      absorbed by plants when spread on alfafa cultures. As this product is eliminated
      to a great extent through the fecal matter, its presence in fertilisers
      constitutes a danger to the environment, in view of its toxicity, whether direct
      or transmitted. This is a further reason for its use to be banned.

PMID- 1026430
TI  - [Effects in the guinea pig of an aerosol with a tributylitin oxide base].
AB  - The authors report a toxicological study of bis (tributyltin oxide) (TBTO) given
      by inhalation (oily aerosol) to 105 Hartley albino guinea pigs. Doses vary from 1
      mg to 0.1 mg of TBTO per liter of aerosol. Death occurs for doses of 0.2 mg per
      le more resistant than the male ones. The intoxication is marked by a period of
      ocular and nasal irritation followed by a short remission time, then death occurs
      after asphyxic convulsions. With doses less than 0.2 mg per liter of aerosol, we
      observe only an irritation without mortality after one hour intoxication. Seven
      days later the animals are alive. Because of its liposulibility, TBTO is present
      in the whole body, particularly in liver, kidney, lung, brain and heart.
      Histological study does not reveal any peculiar lesion of the examinated organs.
      Especially there is no specific alteration of the respiratory system. The merely
      observed trouble is a diffuse congestion.

PMID- 1026431
TI  - [Toxicologic evaluation of irradiated corn starch by long term experimentation
      with rats].
AB  - Maize starch pasteurized by irradiation was fed to OFA rats (Sprague Dawley
      derived) in an uncooked form (irradiated at 300 krad.) and in a cooked form
      (irradiated at 300 and 600 krad.) at dietary level of 62%. A six month toxicity
      trial was performed with uncooked starch and a 24 month trial with cooked starch.
      At the same time a reproduction study was conducted, over 3 generations with 2
      litters per generation, using both uncooked and cooked irradiated starch. The
      parent generation (Fo) was randomly selected from animals in the feeding study
      and after the production of the F1a and F1b generations they were returned to
      that study. Control groups corresponding to each form of starch were established.
      They were fed the same diet except that the starch was not irradiated. The
      results of the various investigations conducted during the study (behavior,
      growth, mortality, haematology, serum biochemistry, histopathology) did not
      reveal any toxicological effect due to treatment, nor any effect on reproduction.
      No significant differences were shown between treated and control group.

PMID- 1026432
TI  - [Acute ethylene glycol poisoning].
AB  - During last 7 years, 13 cases of acute ethylene glycol poisoning have been
      observed with 4 fatal outbreaks. All cases--except one--were accidental. Six
      patients had drunk a mixture of antifreeze in water as they were lost in a
      desert. A patient who had taken 970 ml of ethylene glycol survived. In one case,
      death was due to irreversible brain damage; two other fatalities occurred from
      cardiorespiratory distress. CNS involvement was noticed in 8 cases and acute
      renal failure-constantly controlled-occurred in 9 patients. Post mortem
      examination has shown bi-refringent calcium oxalate crystals in both kidney and
      brain. Specific treatment with ethanol has been performed in 3 cases with
      ingestion of large amounts of toxic who were seen before definitive renal lesions
      have occurred. Emphasis is placed in symptomatic treatment including gastric
      lavage, extrarenal epuration and conservative management.

PMID- 1026433
TI  - The family and the school: utilizing human resources to promote learning.

PMID- 1026434
TI  - An exploration of the dynamics of the overlapping worlds of work and family.
AB  - The relationship between the working lives and family lives of people in our
      society is a concern to both families and corporations. This article describes a
      research project that yielded theoretical statements about the interactions
      between organization life and family life for members of large corporations;
      grounded theory methodology and a systems theory approach were used. Data were
      obtained in a large multinational corporation from managers and their families
      who were undergoing three different kinds of organizational stress: international
      transfer, extensive travel, and job change to facilitator of personal and
      organizational change. The findings give reason for viewing organization and
      family as interacting systems and for considering the uniqueness of each
      individual's response to stressful events. They also indicate that an
      individual's feeling of influence over stressful events at the organization
      family boundaries are significant for both organizational and family
      effectiveness.

PMID- 1026435
TI  - Individuation: from fusion to dialogue.
AB  - Growing interest in concepts of fusion and individuation within a number of
      different theoretical systems of psychotherapy suggests an emerging shift in
      perspective in the conceptualization of psychopathology and psychotherapy. This
      shift may represent a first step in the integration of individual and relational
      dynamic theories. A theoretical framework for the exploration of processes of
      fusion and individuation is presented, with suggested applications for the study
      of problems experienced by adult couples. The process of individuation from
      fusion to dialogue is outlined in the description of four modes of relationship.
      In this context, the paper suggests ways in which a variety of problematic
      relational patterns seen in couples may be viewed as reflecting the partners'
      struggles to move from fusion to dialogue.

PMID- 1026436
TI  - Family therapy in treatment of the deaf: a case report.
AB  - Deaf patients with psychological problems have developmental handicaps and
      clinical characteristics that reduce the effectiveness of traditional modes of
      psychotherapy. Attempts have been made to utilize individual and group therapy,
      but family therapy has been largely overlooked as a method of alleviating
      problems of the deaf. Clinical and research writings provide us with rich
      insights into the family dynamics of the deaf. These data suggest to the authors
      that the problems of deaf individuals are largely related to family problems, and
      therefore merit a family orientation as the focus for treatment. This paper
      describes an attempt to apply family therapy with a range of deaf patients over a
      period of two years. From a review of their work, the authors conclude that
      family therapy can be effective, particularly in the treatment of deaf
      adolescents and children.

PMID- 1026437
TI  - Experimenting with family treatment approaches to alcoholism, 1950-1975: a
      review.
AB  - The attention given family therapy approaches to alcoholism has been
      disproportionately low in relation to the magnitude of alcohol abuse as a
      clinical problem and its acknowledged impact on family life. Although the
      literature to date is limited and most studies should be characterized as pilot
      in nature, preliminary results have enthusiastically endorsed family therapy
      approaches to alcoholism. This critical review assesses the existing experimental
      and clinical literature of the pase 25 years. It also offers potential
      explanations for the reluctance of family therapists to engage this problem more
      actively.

PMID- 1026438
TI  - A method for co-therapy for schizophrenic families.
AB  - This paper describes a model of treatment for families in which one child has
      been given the diagnosis of schizophrenia. Male and female therapists adopt
      structured roles that are used as a paradigm for exploring family patterns. The
      paradigm employs a three-generational hypothesis that defines schizophrenia as a
      lifelong, restricting mode of relating, involving the primary family triad, that
      makes the child vulnerable to repeated psychotic episodes. Therapy is directed at
      the difficulties of autonomous development within the family by focusing on
      differentiating the relationship between nuclear and extended family members,
      expecially defining and strengthening generational and sexual boundaries. The
      second focus of therapy is on the resolution of issues of separation and loss,
      with attention to unresolved mourning in the family of origin and the concomitant
      stress in giving up the infantile relationship with the index child in the
      nuclear family. Stages of therapy will be described including: (a) initiation of
      therapy, (b) breaking of fusion, (c) repair of alienation, and (d) solidifying
      the marital alliance and generational boundaries. Case illustrations will be
      included.

PMID- 1026439
TI  - Family of origin as a therapeutic resource for adults in marital and family
      therapy: you can and should go home again.
AB  - This paper presents a general method of involving adults who are in marital and
      family therapy in sessions with their family of origin, offering a clinical
      application of the author's depth theoretical orientation. The method is based on
      the thesis that current marital and family difficulties are elaborations of
      relationship problems of the spouses in their original families. If adults are
      able to go back to deal directly with past and present issues with their families
      or origin, an opportunity exists for reconstructive changes to come about in
      their present family. This present work is compared with Bowen's methods.
      Procedures are outlined for preparing for these sessions and for overcoming
      resistances. Typical courses these sessions tend to take are described, and some
      preliminary results are presented. Several case histories are presented, and
      theoretical and clinical implications of this method are discussed.

PMID- 1026440
TI  - The product of the consensus Rorschach in families of male schizophrenics.
AB  - A consensus Rorschach was given to the families of 36 male schizophrenics, 13
      psychiatrically hospitalized nonschizophrenic controls, and 38 normal controls
      with the goal of discriminating the families of schizophrenics from the other two
      groups of families. After the family agreed on a response, each member was asked
      to write the response on a separate sheet of paper. This study focused on these
      written responses, the product of the interaction, rather than on the process of
      reaching agreement. A system was developed to score the responses based on the
      degree of shared meaning achieved by the family. Adequate interscorer reliability
      was obtained. The scores significantly differentiated the three groups. More
      families of schizophrenics had low scores indicating lack of shared meaning than
      families of hospitalized and normal controls. In the normal control group, more
      upper-class families had high scores than lower-class families, wheras in the
      schizophrenic group there was a trend in the opposite direction.

PMID- 1026441
TI  - Problems in measuring the success of family therapy in a common clinical setting:
      impasse and solutions.
AB  - Families treated in conjoint therapy in the outpatient clinic of a general
      community hospital for about a year and other families that refused further
      contact with the same clinic after no more than two interviews were followed up
      about four and a half years later. The main difference found was that the treated
      group reported more new symptoms. The complexities of interpreting the data
      obtained are used as a basis for discussing problems that confront, and may
      deter, clinics attempting to evaluate their clinical work by means of controlled,
      nonfactorial or related designs. Process or correlational studies are suggested
      as an alternate choice.

PMID- 1026442
TI  - The incest taboo and family structure.
AB  - The evolutionary advantage of outbreeding has influenced the family structure and
      the mating, attachment, and dominance behaviors of all animals. Nature has
      selected for those species that have evolved family structures with detachment
      and dominance patterns that create a relatively intact incest barrier. Man
      inherits from his animal forebears the biological imperative of an incest barrier
      but brings to it his special complexity of psychology and symbolization--incest
      barrier becomes incest taboo. We present a discussion of human patterns of
      speparation-individuation and Oedipal conflict and relate this to the detachment
      and dominance behaviors of animals. This is an interface between psychoanalysis,
      family theory, and ethology. In addition, we pursue in detail the asymmetrical
      operation of the incest taboo within the family: that it is stronger for mother
      son than for father-daughter than for brother-sister.

PMID- 1026443
TI  - Balance theory: possible consequences of number of family members.
AB  - This paper outlines one theoretical issue involved in considering the
      relationships that may exist in a family. The usual approach is to treat the
      family as a whole, made up of n members. The main issue here is the effects of
      the numerical size of the family and the many possible total and sub-total
      relationships that may exist within family constellations. Family structure and
      function is multivariate, but the focus here is the numberical factor.

PMID- 1026444
TI  - An effect of change in patient status on marital interaction.
AB  - In the treatment of couples and families, even more so than of individuals,
      therapists invariably are forced to face the problem of assessment of change in
      the marital or family "system." The purpose of the present study was to
      investigate changes in marital interaction for a special population, that is, in
      which one member of each married pair had been, but was no longer, a hospitalized
      psychiatric patient. The primary question we addressed was whether changes in
      marital interaction could be amply detected and whether these changes could be
      attributed to the particular role shift that had occurred in one spouse--from
      "patient" to "nonpatient." Utilizing a technique called Interaction Testing,
      which the senior authors devised in 1960, we found that such alterations in
      marital interaction do indeed arise when one member of the couple moves out of a
      patient role and that our instrument is useful in elucidating the nature of such
      effects. In addition, it can be expected that a study of this kind will be of
      theoretical and methodological value in dealing with the general issues of
      problem-solving interaction in couples and families. The clinical aspect of the
      study may also be expected to stimulate useful thinking regarding family theapy
      in hospital settings, patient management, and aftercare.

PMID- 1026445
TI  - Family photographs: in treatment and training.
AB  - The universal appeal of nostalgia and reminiscence makes photographs a natural
      instrument for studying the impact of the past upon the present. This paper
      explores photography as a medium for facilitating reminiscence to discover
      individual roles, interpersonal relationships, and family dynamics. A method is
      described for using family photographs in treatment and training of clinicians at
      a Family Therapy Clinic.

PMID- 1026446
TI  - The dynamics of owning and disowning: psychoanalytic and family perspectives.
AB  - The dynamics of owning and disowning one's inner life have both intrapsychic and
      transactional or interpersonal dimensions. Freud opened new vistas on our inner
      world using psycoanalysis as a tool. Although not unaware of the effects of
      family members upon each other, Freud's rejection of the seduction theory of
      neurosis in 1897 fatefully influenced the future course of psychoanalysis,
      placing the primary focus on intrapsychic relations. Until today, it has remained
      the task-perhaps the principal one--of psychoanalytic theorists to do justice to
      the interpersonal and family realm that Freud neglected, without sacrificing the
      enormous insights we owe to Freud. Three conditions for successful inner
      ownership are described: a capacity for self-object differentiation; tolerance of
      ambivalence; and a sense of physical integrity, of having a cohesive, nuclear
      ego. The pathology of inner ownership is related to a pathology of interpersonal
      ownership as transacted on the family level. One form of such relational
      pathology--parental overowning, as revealed primarily in families with
      schizophrenic members--is discussed, with a case example.

PMID- 1026447
TI  - Lack of acknowledgment in the family Rorschachs of families with a child at risk
      for schizophrenia.
AB  - Lack of acknowledgment, a characteristic of the direct interactions of families
      of schizophrenics, was found also to characterize the Family Rorschach
      interactions of families whose disturbed, non-psychotic adolescents were assessed
      at high risk for schizophrenia on the basis of parental communication deviance.
      The same high-risk families had unbalanced interaction patterns as reflected in
      three measures of family structure.

PMID- 1026448
TI  - The family-school interview: an eco-structural approach.
AB  - This paper describes the family-school interview, and intervention with a child,
      family, and school, taking into account the dynamics of each system in that
      ecological context and the structural interrelationships of these systems
      relative to the problem presented by the child.

PMID- 1026449
TI  - Family systems model in organizational consultation: vignettes of consultation to
      a day-care center.
AB  - "Bowen Theory," 1adapted to organizational dynamics, is presented as a framework
      for understanding the dysfunctional behavior of individuals in the context of a
      particular organization.

PMID- 1026450
TI  - "Enmeshment" and "fusion".
AB  - The paper examines two related concepts utilized by two different schools of
      family therapy. Any family seen to be "enmeshed" is also seen as "fused," and
      vice versa. The difference in the level of focus, on the "system containing the
      individuals" (structural) or the "individual in the system" (fusion), determines
      the difference in therapeutic approach of these two schools.

PMID- 1026451
TI  - Case studies in the family treatment of drug abuse.
AB  - This article, with case illustrations, attempts to demonstrate that drug-abuse
      behavior can be understood more clearly in the light of family loyalties and
      unresolved family crises than from the perspective that drug abusers are social
      deviates.1 Drug abuse is viewed as symptomatic, as a signal that both drug abuser
      and his or her family are having difficulty in getting past a particular stage in
      the natural unfolding life cycle of a family. Treatment of drug abuse is seen
      primarily as helping the family to become "unstuck," thereby freeing the
      individual's and family's energy for the task of self-development and growth
      rather than expending it to maintain rigid patterns of interaction in an attempt
      to prevent change.

PMID- 1026452
TI  - Observations on two natural amnesias.
AB  - The role of interpersonal sequences in determining amnesias has not been as
      explored as the role of intrapsychic conflict. This paper examines two natural
      amnesias, emphasizing their function as part of the process of sequencing
      phenomena.

PMID- 1026453
TI  - Temporal patterning in the family.
AB  - The authors propose that time be considered as a variable in family process.
      Previous theory and research on human temporal patterning and experience are
      reviewed, and empirical generalizations from an initial pilot study concerned
      with marital and family members' orientation to "morningness" and "nightness" are
      presented. Further implications from this work-in-progress are delineated.

PMID- 1026454
TI  - A typology of family social environments.
AB  - A sample of 100 families measured on ten dimensions of their social environments
      was subjected to cluster analysis to develop an empirically based taxonomy of
      families. Six distinctive clusters of families were indentified: Expression
      Oriented, Structure-Oriented, Independence-Oriented, Achievement-Oriented,
      Moral/Religious-Oriented and Conflict-Oriented. The clusters showed systematic
      differences in background characteristics such as size, ethnic minority
      composition, drinking patterns, and family disturbance and incongruence. Some
      evidence that certain clusters of families are composed of different sub-clusters
      was presented. An empirically derived taxonomy of the social environments of
      families may help to understand how different family environments are linked to
      different family outcomes.

PMID- 1026455
TI  - Designed experience: a multiple, goal-directed training program in family
      therapy.
AB  - A family-therapy training program, one of three main branches of the "Boston
      model," is described in detail. Salient features of the program include planned
      integration of a multiplicity of experiential and cognitive learning modes;
      grounding in a unified, theoretical framework that is neither eclectic nor
      limited to a single school of thought; focus on nonpathological process in
      families; and systematic structuring in terms of specific, articulated, training
      objectives. The goal-directed design process by which training units are
      developed is explained.

PMID- 1026456
TI  - Depression and marital interaction.
AB  - A family-systems model of depression is presented and discussed. In this model,
      the intrapsychic concept of cognitive schema and the interpersonal concepts of
      social stimulation and social reingorcement are integrated within a systems
      theory perspective. The effects of positive and negative feedback are delineated,
      and a concept of depression-triggering and depression-maintaining feedback loops
      is described. A clinical illustration is utilized to exemplify the theoretical
      model.

PMID- 1026457
TI  - An integrated treatment program for psychogenic pain.
AB  - The family characteristics associated with the presence of recurrent abdominal
      pain are identified. The involvement on the pediatrician and the effects of this
      involvement on the patient, family, and perpetuation of the symptoms are
      described. A successful therapeutic program combining behavior modification and
      family therapy is elaborated. Changes in the structure and functioning of the
      family are vital to the outcome of therapy and the prevention of recurrence of
      symptoms.

PMID- 1026458
TI  - Social networks, support, and coping: an exploratory study.
AB  - This paper reports a study that investigated the areas of stress, support, and
      coping, using the structural model of the social network. The social network
      model is borrowed from sociology and anthropology and is used to describe and
      quantify not only an individual's immediate family but also all of those with
      whom the individual has regular contact. By comparing the networks of a sample of
      "normal" and schizophrenic males, it was possible to identify differences in
      their relationships to their social networks, in the make-up of the networks
      themselves, and in the coping styles and recent histories of the subjects. The
      results suggest, first, that the network model can be used to investigate the
      larger social system with which individuals interact and, second, that it may be
      a valuable approach to the expansion of family research.

PMID- 1026459
TI  - The consultation-demonstration interview.
AB  - In recent years the consultation-demonstration interview, in which a family is
      interviewed before a workshop, has become increasingly prevalent. While this
      method of presenting the therapist's style of interviewing can be an exciting and
      valuable learning experience, it can also lead to a sense of boredom and
      disappointment. In some instances, the experience can be traumatic, especially
      for the family and the guest therapist. Common pitfalls in the organization and
      planning of the interview are explored, and a number of specific recommendations
      are made for attempting to maximize the potential in this interview process.
      Written to both the planner and the leader of the workshop in family therapy,
      this paper is based on the author's personal experience.

PMID- 1026460
TI  - The use of teaching stories in conjoint family therapy.
AB  - Two general factors have been singled out as being held in common by all types of
      psychotherapy: an educational, rational factor (often called "content") and a
      factor operative in the relationship between the therapist and his patient (often
      called "process"). In the field of family therapy, the non-educational aspects of
      intervention are sometimes presented in the form of "therapeutic, paradoxical
      communications" (Haley, Bateson, Jackson, Weakland) or the 'therapy of the
      absurd" (Whitaker, Malone). In the present paper, I wish to present a form of
      therapeutic communication, the teaching story, that embodies a unique mixture of
      both the educational and the paradox, or absurd.

PMID- 1026461
TI  - "Nonlabeled" family interaction: prelimiary report on a prospective study.
AB  - This paper is a preliminary report on the first year of a two-year exploratory,
      prospective study of psychiatrically "nonlabeled" families. The project studies
      families from a nonpathology-oriented point of view. It focuses primarily on
      whole-family interaction as it progresses through time. Because of limited funds,
      only two families are being studied in this exploratory phase. Nevertheless, the
      work touches on many issues of a general nature that may be of interest of other
      researchers. Each family has been interviewed once a month for the past year. The
      paper outlines: procedural matters, including selection criteria and recruitment;
      data collection, including interviews, rating scales, and "clinical" discussions;
      processing of data; preliminary findings, including quantitative and qualitative
      aspects; and problem areas, including methodological and ethical aspects.

PMID- 1026462
TI  - [Increasing work quality and the efficiency of pharmaceutical production].

PMID- 1026463
TI  - [Quality and efficiency].

PMID- 1026465
TI  - [Experience with the work of a pharmacy in a clinical institution].

PMID- 1026464
TI  - [Communist attitude toward work in the pharmaceutical institutions of the Poltava
      region].

PMID- 1026466
TI  - [Differential UV spectroscopy of flavonoids].

PMID- 1026467
TI  - [Synthesis and diuretic activity of amides and hydrazides of arensulfoacids].

PMID- 1026468
TI  - [Interaction of several alkaloids with di-(2-chlorethyl) amine derivatives].

PMID- 1026469
TI  - [Training and employment of pharmaceutical workers in the public health system of
      our country].

PMID- 1026470
TI  - [Aqueous solutions of a lyophilized polyphenol preparation of propolis].

PMID- 1026471
TI  - [Methylhydroxypropylcellulose as a base for hemostatic preparations].

PMID- 1026472
TI  - [Role of the clinical hospital pharmacist at the present stage of development of
      public health].

PMID- 1026473
TI  - [Dynamics of accumulation of essential oils in specimens of Anethum graveolens of
      different geographic origin].

PMID- 1026474
TI  - [Quantitative determination of furosemide].

PMID- 1026475
TI  - [New qualitative tests for several tryptamine derivatives].

PMID- 1026476
TI  - [Increasing the accuracy of interferometric determination of salsoline
      hydrochloride].

PMID- 1026477
TI  - [Chemical composition of Oxytropis talassica].

PMID- 1026478
TI  - [Statistical treatment of experimental findings].

PMID- 1026479
TI  - [The international unit system (SI) in pharmacy].

PMID- 1026480
TI  - [Role of pharmacists in the solution of the basic problems of public health].

PMID- 1026481
TI  - [Study of the competence of the population with the problems of choosing, storing
      and using drugs and patient care products at home].

PMID- 1026482
TI  - [Norms for the expenditures for raw material and auxiliary material in the
      production of drugs at pharmaceutical enterprises in the Ukraine].

PMID- 1026483
TI  - [Organization of medical care for psychoneurological patients].

PMID- 1026484
TI  - [Pharmacology of diuretic agents].

PMID- 1026485
TI  - [o- and m-dinitrobenzenes and their derivatives as reagents in the analysis of
      organic drugs].

PMID- 1026486
TI  - [Tasks of pharmaceutical schools and faculties in accomplishing Decision No. 535
      of the Central Committee of the CPSU and of the Council of Ministers of July 18,
      1972, "Measures for the further improvement of higher education in the USSR"].

PMID- 1026487
TI  - [Synthesis and biological activity of 3-amino-3-phenyl-2-indolinones].

PMID- 1026488
TI  - [Synthesis and properties of 2-oxy-1,3-di-(thiazolidindion-2',4'-yl-3')-propane
      and its derivatives].

PMID- 1026489
TI  - [Synthesis and the action of adamantane derivatives on the Sindbis virus].

PMID- 1026490
TI  - [Methylation of isatin thio- and selenosemicarbazones].

PMID- 1026491
TI  - [Phosphorylated amide derivatives of trichlorobenzoic acid].

PMID- 1026492
TI  - [Use of chromatography on a thin layer of sorbent for the analysis of erysimine].

PMID- 1026493
TI  - [Use of AC polarography for the identification and quantitative determination of
      benzotef and its analogs].

PMID- 1026494
TI  - [Photoelectrocolorimetric method of determining morphine in alcohol-ammonia
      mother liquors].

PMID- 1026495
TI  - [Fluorescent method of determining the activity of gitoxin].

PMID- 1026496
TI  - [Effect of the hydrodynamic characteristics of the fluidized bed on the
      homogeneity of tablet coating].

PMID- 1026497
TI  - [Assessment of the technical and economic effectiveness of new technological
      procedures].

PMID- 1026498
TI  - [Study of the process of extracting the total iridoids from the herb Odontites
      serotina].

PMID- 1026499
TI  - [Government awards].

PMID- 1026500
TI  - [Development of a technology for phenformin tabletting].

PMID- 1026501
TI  - [Study of the stability of Ringer's solution in combination with glucose or
      novocaine in large packages].

PMID- 1026502
TI  - [Development of a technology for flavonoid composition tablets].

PMID- 1026503
TI  - [Interferometric method of determining cocarboxylase hydrochloride up to 0.05 g].

PMID- 1026504
TI  - [Effect of dimethyl sulfoxide on heart functions].

PMID- 1026505
TI  - [Technology of drugs from papaverine hydrochloride].

PMID- 1026506
TI  - [Inhibition of the activity of human serum cholinesterase by aminoalkyl
      benzenesulfonyl fluorides].
AB  - Aminoalkyl benzenesulfonyl fluorides, like organophosphates, act as irreversible
      inhibitors of serine proteinases by splitting off hydrogen fluoride to form an
      enzyme-inhibitor complex, stable in the physiological pH region. Several of these
      compounds are characterized by a higher rate of inhibition when trypsin is used
      and the second order rate constants are compared with those of organophosphates.
      On the other hand, upon inhibition of human serum cholinesterase by DFP and 4
      nitrophenyl diethyl phosphate, some orders of magnitude higher than that of
      benzenesul fonyl fluorydes are observed. As shown by an oral toxicity study in
      mice similar differences exist with respect to LD50 values.

PMID- 1026507
TI  - [Effect of lithium chloride on bioelectric activity of the cortex and various
      subcortical structures of rabbit brain].
AB  - In a dose of 100 mg/kg and with intravenous administration to rabbits lithium
      chloride produces a depressing influence on the spontaneous bioelectric activity
      of the cerebral cortex and its subcortical formations, which extends from the
      cortex to subcortical structures. The compound brings down the electric
      excitability of the hippocampus, caudate nucleus, tonsils, reticular formation of
      the mesensephalic segment and of the thalamus, while in a dose of 300 mg/kg it
      increases the excitability of the motor cortex. No correlation between the
      lithium chloride induced electroencephalographic changes in the cerebral
      structures, on the one hand, and the content therein of biogenic amines and
      accumulation of lithium ions, on the other, was revealed.

PMID- 1026508
TI  - [Effect of lithium chloride on kidney function in rats].
AB  - Test staged on rats have brought evidence that lithium chloride acts damagingly
      on all parts of the nephron, inhibiting, first of all, the processes of
      filtration and then of secretion and reabsorption. Polyuria arising under the
      effect of lithium is caused by reduced reabsorption of water in the tubules and
      anuria--by depression of the glomerular filtration.

PMID- 1026509
TI  - [Elimination of products of fluoracizine by the gastrointestinal tract in animals
      of different species].
AB  - A study on elimination of phthoracizine metabolites with feces of different
      animal species evidenced that bulk of its transformation products with an intact
      side-chain was contained in the feces of rats. In the feces of mice they are
      found in much smaller amount, while in rabbits they are practically untracable.
      The phthoracizine transformation products devoid of the side-chain are
      demonstrable both in rats and in other animal species either as traces or not
      definable at all. These phenomena are, apparently, to be attributed to a
      different ability of eliminating the phthoracizine biotransformation products
      with bile by different animal species, which, among other factors. is determined
      by the molecular weight of individual metabolites.

PMID- 1026510
TI  - [Local-anesthetic activity of l-aminoacetyl-2, 3-dihydroindole derivatives].
AB  - 1-(N-piperidine-acetyl)-2,3-dihydroindoles display high activity in infiltration
      and conduction anestheia, exceeding that of trimecaine. N-alkylaminoacetyl
      indolines are moderately active, while N-morpholine and N-indolylacetyl-indolines
      are practically inactive when employed in the given types of local anesthesia.
      All the N-substituted aminoacetyl-indolines are little active in terminal
      anesthesia.

PMID- 1026511
TI  - [Relationship between chemical structure and anti-arrhythmic effect of ethmosine
      analogs].
AB  - The relationship between the chemical structure and antiarrhthmic action in the
      series of 10-actlaminopropionyl phenothiazine derivatives with different urethan
      groups in the second position of the phenothiazine cycle (methy, ethyl and
      isobutyl) was studied. Subject to investigation were also aetmozine isomers
      containing ethyl-carbaminate in the first, third and fourth position, as well as
      compounds containing aminopropionyl residues in the tenth and trifluoromethyl
      group or bromine in the second position. The available data indicated that the
      antiarrhythmic action of 10-acylamino-derivatives of phenothiazine depends not
      only on the structure of the side chain and substitution of hydrogen in the
      second position of the phenothiazine nucleus, but also upon the position of the
      urethan group in the phenothiazine cycle. Moving ethyl-carbaminate to the first,
      third and fourth positions results in the fall of the anti-arrhythmic action. The
      absence of any relation between the length of the urethan radical and the effect
      produced by the substance was also shown. By substituting the methyl or isobutyl
      radicals for the ethyl one the antiarrthythmic action of the substances declines.

PMID- 1026512
TI  - [Effect of phenobarbital, morphine and ethanol on the physico-chemical properties
      of erythrocyte membranes].
AB  - The effect of narcotics--phenobarbital, morphine and ethanol on the hemolysis of
      erythrocytes in a hypotonic solution was studied. The narcotics under study are
      shown to influence the stability of the erythrocytes membranes. Behind the
      mechanism of stabilization apparrently lies the action of the said substances on
      the critical hemolytic volume of the cells. A common nature of some mechanisms
      underlying the action of phenobarbital, morphine and ethanol on the erythrocytes
      membranes is suggested.

PMID- 1026513
TI  - [Effect of no-shpa, halidor, dibazol and euphylline on the fibrinogen content and
      fibrinolytic activity of blood].
AB  - With a single intravenous administration to albino rats of both sexes of nospanum
      and halidor in a dose of 2 mg/kg and dibazol--in 1 mg/kg produce activation of
      fibrinolysis, while euphylline in a dose of 12 mg/kg has no effect on this
      process. A protracted introduction by the subcuataneous route of halidor and
      nospanum in a dose of 10 mg/kg, of dibazol--in 5 mg/kg and of euphylline
      intramuscularly in a dose of 24 mg/kg depresses in animals the activity of the
      proteolytic process. It was found that in vitro nospanum, halidor and dibazol
      accelerate fibrinolysis, whereas the presence of euphylline in the blood plasma
      deccelerates this process.

PMID- 1026514
TI  - [Characteristics of the antivitamin effect of pyriditol, a disulfide pyridoxine
      derivative, on animal body].
AB  - Intraperitoneal administration of disulphide pyridoxine (pyriditol) to albino
      mice in a dose of 300 mg/kg brings down the GABA level and the GABA-transaminase
      activity in the brain, the glutamic acid content and the glutamate-decarboxylase
      activity remaining unchanged. In the liver and, especially, in the kidneys of
      test animals the activity of aspartate-and alanine-aminotransferase goes down.
      The diurnal urinary output of the animals shows a decreased passage of 4
      pyridoxic acid. These results are interpreted to be consequent upon the
      antivitamin action of pyriditol with respect to pyridoxine.

PMID- 1026515
TI  - [Anti-inflammatory effect of methylmethionine sulfonium chloride (vitamin U)].
AB  - Tests conducted on mice demonstrated that methylmethionine-sulfonium chloride
      (vitamin U) is capable of lowering the permeability of the skin capillaries
      following the action of stimulants. It greatly potentiates the antiphlogistic
      effect of acetylsalicylic acid, this action being more pronounced with vitamin U
      administered one hour before intake of acetlsaliclic acid than when both are
      taken simultaneously. Given in a dose of 1000 mg/kg vitamin U helps reduce
      exudation in aseptic serosites in rats. The antiphlogistic effect of vitamin U
      comes in conjunction with its ability to exercise a protective action against
      lesion of the gastric mucosa produced by acetylsalicylic acid.

PMID- 1026516
TI  - [Relationship between accumulation of o,p'-dichlorodiphenyl-dichloroethane in the
      adrenal glands and their function and structure].
AB  - Over a periof of 12 days following introduction of o'p-dichlordiphenyl
      chlorethane to dogs in a dose of 25 mg/kg a sizable accumulation of the compound
      in the adrenal tissue, a drastic inhibition of its function and deragment of the
      suprarenal cortex structure are observed. After a 28-day administration of the
      compound the functional and structural upsets in the adrenals gain in strength,
      whereas it concentration in this organ declines.

PMID- 1026517
TI  - [Combined use of estradiol and insulin in experimental diabetes].
AB  - Experiments demonstrated that in diabetes subject to inhibition are the processes
      of respiration and phosphorylation and that estradiol-dipropionate in dose of 50
      gamma/kg did not change significantly either utilization of oxygen, or attended
      by it phosphorylation in the uterus and liver, while in a dose of 100 gamma/kg it
      contributed to the combination of the respiratory and phosphorylation processes
      in the liver alone. Joint administration of insulin and estradiol restored nearly
      to the initial level the rate of the oxygen consumption and esterification of
      inorganic phosphorus in the uterus and liver.

PMID- 1026518
TI  - [Effect of caffeine on the content of the components of the adenyl system and on
      the activity of p32 incorporation into the myocardium of rats during early
      periods of their growth].
AB  - Caffeine sodium benzoate was injected intraperitoneally at one time in doses of 1
      and 50 mg/100 g to rates aged 30 days and 3--5 months. The ATP, ADP, AMP,
      inorganic phosphorus levels and the p32 incorporation activity were determined in
      the myocardium. Introduction of the drug in a dose of 1 mg/100 g is shown not to
      produce any substantial shifts on the level of the study indices in 7-day old and
      adult animals and to increase the ATP content in 30-day old rattlings.
      Administration of caffeine in a dose of 50 mg/100 g brings down the ATP content
      in the myocardium of the animals in all the age categories. As regards the degree
      of the ATP level changes the 7-day old rattlings are more resistant than are the
      adult animals.

PMID- 1026519
TI  - [Pathomorphological study of antiviral chemotherapeutic effectiveness of
      bonaphthon under experimental conditions].
AB  - A pathomorphological study of antiviral chemotherapeutic activity of benaphthon
      was carried out in tests involving intranasal inoculation of mice with influenza
      A2 (Hong Kong) 68 viruses (infection doses of 1 DL75 and 10 DL75) and of rabbits
      with herpetic keratitis, provoked by the herpes simplex virus (strain Ela-5699).
      A single prophylactic introduction of bonaphthon with subsequent 4-day treatment
      of experimental influenzal pneumonia of mice was found to produce a significant
      diminution in the frequency of the pneumonia development in experimental animals,
      a reduction in the number of severe and lethal forms of the malady and, by
      preventing the development of morphologically grave forms, to improve the
      prognosis. The use of bonaphthon in experimental herpetic keratitis of rabbits,
      irrespective of the mode of its administration (locally or by mouth) cuts down
      the period of the keratitis cure almost in half, contributes to a speedier
      epithelization of the ulcerated surface and to the disappearance of inflammatory
      manifestations in the very substance of the cornea.

PMID- 1026520
TI  - [Characteristics of chemical structure of analogs of the antimalarial drug
      chloridine (pyrimethamine), detetermining their teratogenic properties].
AB  - On an example of substituted 2,4-diaminopyrimidines containing at the 6th
      position hydrogen, alkyl radicals with a varying length of chains, ramified
      isoalkyl radicals and aromatic nuclei it is shown that the teratogenous activity
      is inherent only in some agents, being related to the chemical structure and
      conformation of the molecules. Accordingly, the principles of elective toxicity
      lying at the root of current chemotherapy may be extended also to teratology.
      From this it follows that there exists as a matter of principle the possibility
      of a purposeful synthesis of new medical compounds that would be devoid of
      teratogenous activity, but were endowed with valuable curative properties.

PMID- 1026521
TI  - [Pharmacological properties of steriod contraceptives (literature survey)].

PMID- 1026522
TI  - Amikacin (BBK8) in infections due to gram-negative organisms in children over the
      age of one month.
AB  - Thirty children over the age of one month were treated with amikacin (BBK8), a
      new aminoglycoside derived from kanamycin A, with three intramuscular dosage
      schedules. Each group consisted of ten patients. The first received 7-5 mg/kg/12
      hours, the second 7-5 mg/kg/24 hours and the third, 3-75 mg/kg/12 hours. The
      infections and the bacteria were similar in all three groups: pyelonephritis,
      abscesses of soft tissues, infected wounds, septicaemia, superinfected empyema,
      gastro-enteritis, chronic otitis media; the bacteria were E. coli, Klebsiella,
      Pseudomonas and Salmonella. A were sensitive by the Kirby-Bauer method, although
      two were resistant by dilution in Petri dish. Of the thirty patients, twenty four
      (80%) were cured. The schedule of 3-75 mg/kg/12 hours was as effective as the
      schedule of 7-5 mg/kg/12 hours for infections such as pyelonephritis, superficial
      abscesses, contaminated wounds, gastro-enteritis and sepsis. The cases with
      infections localized in rather unaccessible sites required double the dose and
      strict drainage and cleanliness. Plasma levels with the administration of 3-75
      mg/kg fluctuated between 8-3 and 12-6 mcg/ml; with 7-5 mg/kg they fluctuated
      between 8-6 and 13-1. The minimum inhibitory level (MIL) for the majority of the
      bacteria was 1-25 mcg/ml. No toxic reactions were observed.

PMID- 1026523
TI  - The determination of disopyramide in blood plasma and urine.

PMID- 1026524
TI  - Cellular electrophysiologic changes induced by disopyramide phosphate in normal
      infarcted hearts.

PMID- 1026525
TI  - The effect of disopyramide on in vivo measurement of monophasic action potential
      in canine heart muscle.

PMID- 1026526
TI  - The effects of disopyramide on the human heart: an electrophysiological study.

PMID- 1026527
TI  - Circulatory effects of intravenous disopyramide in heart failure.

PMID- 1026528
TI  - Haemodynamics of intravenous disopyramide.

PMID- 1026529
TI  - The pharmacokinetics of disopyramide following myocardial infarction with special
      reference to oral and intravenous dose regimens.

PMID- 1026530
TI  - Correlation of disopyramide pharmacokinetics with efficacy in ventricular
      tachyarrhythmia.

PMID- 1026531
TI  - The excretion of D-glucaric acid in the urine of human volunteers following the
      administration of disopyramide.

PMID- 1026532
TI  - Anti-arrhythmic therapy: present views and future prospects.

PMID- 1026533
TI  - Some aspects of the clinical pharmacology of intravenous disopyramide after
      myocardial infarction.

PMID- 1026534
TI  - The pharmacology of disopyramide.

PMID- 1026535
TI  - Acute termination of cardiac arrhythmias with intravenous disopyramide.

PMID- 1026536
TI  - The use of disopyramide in the treatment of arrhythmias in ambulatory patients.

PMID- 1026537
TI  - Anti-arrhythmic and haemodynamic effects of intravenous and oral disopyramide in
      patients with ventricular arrhythmia.

PMID- 1026538
TI  - Disopyramide in patients with ventricular premature beats: an experimental model
      and preliminary results.

PMID- 1026539
TI  - Methenamine hippurate ('Hiprex') in the treatment of chronic urinary tract
      infections: a trial in a geriatric hospital.
AB  - Fifty-two patients, all of whom were more than 66 years-old and who were
      hospitalized for periods in excess of two years were treated for chronic urinary
      tract infection. All patients received a course of antibiotic treatment for seven
      to ten days and were then put onto treatment with methenamine hippurate 1 g twice
      daily for six months. Of the original fifty-two patients, twelve did not complete
      the six month course. During the six month period with "Hiprex' there were far
      fewer re-infections than in the previous six months during which time they had
      received intermittent antibiotic therapy and other long-term treatment. There
      were no adverse reactions and bacterial resistance did not occur.

PMID- 1026540
TI  - Treatment with methenamine hippurate in the patient with a catheter.
AB  - Methenamine hippurate, 1 g twice daily, was given for four months to twenty-two
      elderly female subjects with an indwelling catheter. The incidence of catheter
      blockage was significantly reduced when compared with the control period of
      similar duration, although bacteriuria persisted throughout treatment. The
      incidence of symptomatic urinary tract infection also decreased during treatment
      with methenamine hippurate.

PMID- 1026541
TI  - A profile for trimipramine.
AB  - A series of sixty-one patients with depressive symptoms were treated with
      trimipramine in single nightly dosages. Analysis of the data indicated that a
      favourable outcome was likely to be associated with the following features:
      absence of gastro-intestinal complaints; absence of hypochondriasis; a level of
      anxiety not more than the average for psychiatric patients; absence of
      situational palpitation; possession of a stable work record; and possession of a
      family history positive for psychiatric disorder. These features are not claimed
      to be specific to treatment with trimipramine. Age, sex, out-patient/in-patient
      status and the over-all degree of depression were not found to be relevant.
      Trimipramine was associated with a favourable outcome in 64% of all cases
      treated, and in 73% of primarily depressive conditions.

PMID- 1026542
TI  - The addition of Visken to methyldopa therapy in hypertension: a multicentre
      study.
AB  - Forty-one patients completed the study where Visken was added to the treatment
      regimen of patients whose blood pressures were poorly controlled on methyldopa or
      who were experiencing side-effects with methyldopa. Supine blood pressure was
      reduced from 177/108 mm Hg before Visken therapy to 159/96 mm Hg after twelve
      weeks of taking Visken. The dose of methyldopa was reduced from a mean 921 mg at
      the start to 445 mg at the end. Fourteen patients were able to stop methyldopa
      therapy. The number of side-effects reported was reduced as the study continued
      and fifteen patients commented that they felt better on Visken. Nine patients did
      not complete the trial, three of these because of side-effects, viz insomnia,
      lethargy and sleep disturbances.

PMID- 1026543
TI  - A clinical trial of temazepam, a sleep inducer, in hospital patients.
AB  - Temazepam, a common metabolite of diazepam and oxazepam, was evaluated as a sleep
      inducer. A dose of 20 mg, in a Scherer capsule formulation, was compared with 200
      mg of amylobarbitone sodium in a between-patients, randomized study. Patient and
      staff assessments were used. No statistically significant difference as to onset
      of sleep, duration or quality of sleep or morning drowsiness was found using the
      patients' assessments. The staff recorded significantly less daytime dozing and
      morning hangover in patients receiving temazepam. Side-effects were mild and
      confined mainly to drowsiness on awakening. Two patients, both on amylobarbitone
      sodium, withdrew from the study because of increasing confusion.

PMID- 1026544
TI  - Cases of overdosage with viloxazine hydrochloride (Vivalan).
AB  - Twelve cases of viloxazine overdosage are reported. All patients recovered
      without sequelae and no ECG abnormalities were observed. Gastric lavage was
      performed in most cases and was probably beneficial. As viloxazine is rapidly
      absorbed (Bayliss & Case 1975, Case & Reeves 1975) lavage should be carried out
      as soon as possible after the tablets are taken. Since the drug is almost
      exclusively excreted in the urine, it is suggested that forced diuresis be
      carried out to reduce blood levels as quickly as possible.

PMID- 1026545
TI  - Treatment of skin and soft tissue infections with cefadroxil, a new oral
      cephalosporin.
AB  - Oral cefadroxil in doses of 0-6-1-8 g per day given on twice or three times daily
      schedules was effective in the treatment of thirty-six patients with infections
      such as abscesses, carbuncles, cellulitis, furunculosis and impetigo.
      Staphylococcus aureus strains and beta-haemolytic streptococci, alone or in
      combination, were cultured from lesions before treatment. In vitro studies with
      test discs showed that all the organisms were sensitive to cefadroxil, but twenty
      three of twenty-nine S aureus strains and one of the seven streptococci strains
      were resistant to penicillin G. Pre- and post-treatment laboratory tests of
      renal, hepatic and haematopoietic functions produced no evidence of drug
      toxicity. The cefadroxil dosage effective in this study is lower than that
      recommended for currently available oral cephalosporins, which must be given on a
      four times daily schedule.

PMID- 1026546
TI  - Effectiveness of two new cephalosporins, cephazolin and cephapirin, administered
      intermittently in acute and chronic osteomyelitis in children.
AB  - Ten patients were treated, most of pre-school age, with acute osteomyelitis,
      produced by Staphylococcus aureus and Salmonella, having evolved for
      approximately one week, with sodium cephazolin at doses of 60 mg/kg/day
      intramuscularly in two daily injections for the first seven days and then in a
      single dose every twenty-four hours for four to seven weeks. Nine of ten patients
      were asymptomatic six months after this treatment. The patient who manifested
      chronic signs at the end of six weeks of therapy continued to be treated with
      three weekly injections of the same drug at an equal dose until the completion of
      six months, at the end of which he was asymptomatic. Ten patients with chronic
      osteomyelitis having evolved for two months to five years, due to penicillin
      resistant Staphylococcus aureus, were treated with cephapirin at the dose of 30
      mg/kg in one daily injection intramuscularly for three to four weeks and then the
      same dose on Mondays, Wednesdays and Fridays until the completion of six months.
      Eight patients who required it were sequestrectomized. Seven of the ten patients
      improve and remained asymptomatic for the same period of observation. The three
      patients who did not show marked clinical improvement did exhibit an appreciable
      radiological recovery. We have presented these regimens of treatment with a view
      of encouraging research into the intermittent administration of bactericidal
      antibiotics for pyogenic infections; in spite of the good results, we do not dare
      to recommend them in daily practice.

PMID- 1026547
TI  - A comparative clinical evaluation of a new topical steroid 'halcinonide' and
      hydrocortisone in steroid-responsive dermatoses.
AB  - Fifty patients with symmetrical, bilateral lesions of psoriasis, eczematous
      dermatitis, atopic dermatitis, or neurodermatitis participated in a double-blind
      paired comparison study in which 0-1% halcinonide (in a cream formulation
      containing also neomycin and nystatin) was applied to the lesions on one side of
      the body and 1% hydrocortisone cream to those on the opposite side for two to
      three weeks. The number of excellent responses to therapy showed the halcinonide
      combination to be significantly superior (p less than 0-01) to the control cream
      in all diagnostic categories if considered collectively, and in psoriasis if the
      responses were grouped according to diagnosis. No adverse reactions occurred
      during the trial.

PMID- 1026548
TI  - The effect of forewarning on the occurrence of side-effects and discontinuance of
      medication in patients on dothiepin.
AB  - Dothiepin was prescribed for 100 depressed out-patients alternately allocated to
      one of two groups. Patients in Group A were forewarned about side-effects and
      patients in Group B were not forewarned. None of the patients had previously
      received dothiepin. After two weeks the patients were questioned regarding side
      effects and continuance with medication. Eighty-nine patients were included in
      the final analysis. The results failed to confirm the hypotheses that forewarning
      patients of side-effects causes a greater number of patients to complain of such
      effects, or that where patients experience side-effects, forewarning is
      associated with any less frequent discontinuance of therapy. Compared with a
      previous study with amitriptyline, the results of this study are much closer to
      statistical significance. This may be due to the lower overall incidence of side
      effects with dothiepin and calls for further work with a larger sample of
      patients.

PMID- 1026549
TI  - Neonatal jaundice--a comparison between intravenous oxytocin and oral
      prostaglandin E2.
AB  - The total serum bilirubin levels at two and occasionally five days after birth
      were studied in 162 infants whose mothers received either intravenous oxytocin or
      oral Prostaglandin te2 during labour, and the results were compared with those
      obtained in forty-two control patients. Following labour of spontaneous onset,
      whether the mother received intravenous oxytocin or oral Prostaglandin E2,
      neonatal total serum bilirubin levels were not different from those in controls.
      After induction by amniotomy and an active agent, higher mean total serum
      bilirubin levels were found in infants whose mothers received intravenous
      oxytocin than in those given oral prostaglandin E2; a significant rise in the
      total serum bilirubin level appeared to occur when mothers received a total of
      more than 12,000 milliunits of oxytocin or more than 4,000 milliunits per kg
      birthweight of the infant.

PMID- 1026550
TI  - Micro-encapsulated aspirin (Levius) compared with aloxiprin (Palaprin Forte) in
      the treatment of rheumatoid arthritis.
AB  - A randomized crossover trial of micro-encapsulated aspirin (Levius) and aloxiprin
      (Palaprin Forte) was carried out on thirty-three hospital outpatients with
      rheumatoid arthritis. Both preparations improved the clincial status of the
      patients. The difference in response to the two preparations was not significant,
      except for effect on functional status where the micro-encapsulated aspirin was
      found to be significantly better at the 5% level. Apart from six complaints of
      constipation with aloxiprin compared with only one with Levius, the side-effects
      were similar. The trial has shown that Levius can be conveniently given in
      divided doses thrice daily without loss of efficacy.

PMID- 1026551
TI  - The use of methionine for acute paracetamol poisoning.

PMID- 1026552
TI  - Cysteamine, L-methionine and D-penicillamine in paracetamol poisoning.

PMID- 1026553
TI  - A controlled trial of cysteamine in the treatment of acute paracetamol poisoning.

PMID- 1026554
TI  - The use of cysteamine and dimercaprol.

PMID- 1026555
TI  - Modification of paracetamol hepatotoxicity by anti-oxidants.

PMID- 1026556
TI  - Fatal drug overdosage.

PMID- 1026557
TI  - Paracetamol, alpha-mercaptopropionyl glycine and some observations on the
      toxicity of protective agents.

PMID- 1026558
TI  - Why paracetamol?

PMID- 1026559
TI  - Isolation and identification of paracetamol metabolites.
AB  - A comparison has been made of the urinary metabolites of volunteers who had taken
      therapeutic doses of paracetamol with those of persons who had taken an overdose
      in an attempt to highlight the metabolic changes associated with massive doses.
      The main technique for examining urine samples was two-dimensional thin layer
      chromatography. Other chromatographic techniques were used for the isolation and
      purification of metabolites. The urinary metabolites after a therapeutic dose of
      paracetamol were identified as free paracetamol, paracetamol sulphate, 3-hydroxy
      paracetamol-3-sulphate, 3-methoxy-paracetamol sulphate, paracetamol glucuronide,
      3-methoxy-paracetamol glucuronide, paracetamol 3-cysteine conjugate and
      paracetamol 3-mercapturate. The same metabolites were also present in urine
      following overdosage but the proportions were quite different. There was
      particularly a big increase in the relative amounts of cysteine and mercapturic
      acid conjugates excreted. No new metabolites were found. The significance of
      these findings is briefly discussed in relation to the metabolism and toxicology
      of paracetamol.

PMID- 1026560
TI  - Metabolism of paracetamol after therapeutic and hepatotoxic doses in man.

PMID- 1026561
TI  - Phenacetin and paracetamol.

PMID- 1026562
TI  - Self-poisoning and suicide due to paracetamol.

PMID- 1026563
TI  - Packaging: can it help to reduce the incidence of poisoning?

PMID- 1026564
TI  - The development of a blood paracetamol estimation kit.

PMID- 1026565
TI  - The paracetamol test-kit in practice.

PMID- 1026566
TI  - A theoretical approach to the management of paracetamol overdosage.
AB  - Possible ways of treating paracetamol hepatotoxicity are briefly reviewed. This
      toxicity appears to be due to an oxidation metabolite which is normally
      detoxified by conjugation with glutathione, but when in excess, as in paracetamol
      overdosage, binds covalently to hepatic proteins to cause liver necrosis.
      Depletion of hepatic glutathione may also lead to other contributory disorders of
      cellular metabolism. Physical methods of preventing this would appear to be of
      little value, and treatments are being developed which aim to lessen the
      production of the toxic metabolite, antagonize its attachment to hepatic tissue
      or to combat this toxicity via basic cellular mechanisms. At this moment the most
      effective substances appear to be glutathione precursors and other compounds
      which interfere with oxidation of paracetamol.

PMID- 1026567
TI  - The transient distribution of allele frequencies under mutation pressure.

PMID- 1026568
TI  - Inheritance of Scottish-type resistance to warfarin in the Norway rat.

PMID- 1026569
TI  - Distribution of crossing-over in mouse chromosomes.

PMID- 1026570
TI  - RP4 fertility variants in Acinetobacter calcoaceticus.

PMID- 1026571
TI  - Hitch-hiking effect - counter reply.

PMID- 1026572
TI  - The future status of the aged.

PMID- 1026573
TI  - Designing with the elderly. A user needs survey for housing low-income senior
      citizens.

PMID- 1026574
TI  - Treating the aged with psychotropic drugs.

PMID- 1026575
TI  - Portrayal of the elderly in prescription drug advertising. A pilot study.

PMID- 1026576
TI  - Membership in different types of voluntary associations and psychological well
      being.

PMID- 1026577
TI  - M*A*S*H. A program of social interaction between institutionalized aged and adult
      mentally retarded persons.

PMID- 1026579
TI  - Project V-strap. An evaluative study of workshops training the aged for community
      service.

PMID- 1026578
TI  - Observations of food acceptance by elderly women.

PMID- 1026580
TI  - Improving elderly clients' attitudes through photography.

PMID- 1026581
TI  - Impact of a friendly visiting program on attitudes of college students toward the
      aged.

PMID- 1026582
TI  - A previous incarnation of disengagement theory. An historical note.

PMID- 1026583
TI  - Clinical engineering in the hospital.

PMID- 1026584
TI  - The patient's right to live or die.

PMID- 1026585
TI  - Alleviation of hospital cleaning problems.

PMID- 1026586
TI  - Changing patterns of child health.

PMID- 1026587
TI  - Delivery unit equipment.

PMID- 1026588
TI  - The National Association for the Welfare of Children in Hospital.

PMID- 1026589
TI  - Fetal monitoring.

PMID- 1026590
TI  - The organisation of a paediatric unit.

PMID- 1026591
TI  - CSSD services for specialised obstetrics.

PMID- 1026592
TI  - Baby care in the '70s.

PMID- 1026593
TI  - Special care baby units.

PMID- 1026594
TI  - Arjo baby bath.

PMID- 1026595
TI  - New hope for heart sufferers.

PMID- 1026596
TI  - Wessex RHA--report of the Regional Ambulance Officer.

PMID- 1026597
TI  - Mechanised cleaning.

PMID- 1026599
TI  - Testing a chair for violent patients.

PMID- 1026598
TI  - Patient administration.

PMID- 1026600
TI  - A fresh look at frozen foods.

PMID- 1026601
TI  - Current developments in health planning (Scotland).

PMID- 1026602
TI  - Locating staff.

PMID- 1026604
TI  - Thoughts on progress.

PMID- 1026603
TI  - Preventing cross-infection.

PMID- 1026605
TI  - The case of the porcelain gallbladder.

PMID- 1026606
TI  - In both Venezuela and Peru, 'simplified medicine' is goal.

PMID- 1026607
TI  - Cancer of the esophagus: the case for irradiation.

PMID- 1026609
TI  - Medical discipline: everybody's business.

PMID- 1026608
TI  - Immunotherapeutic approaches to skin cancer.
AB  - Topical application of a relatively low concentration of one or more agents to
      which the patient has previously been sensitized can mobilize cell-mediated
      immune systems at the site of neoplastic or premalignant lesions. Such treatment
      has proved to be effective against both primary and metastatic skin lesions. It
      is also suggested that dermatologic experience may provide a model for other
      cancer immunotherapies.

PMID- 1026611
TI  - Food for thought.

PMID- 1026610
TI  - Portugal's doctors accept revolution and prosper.

PMID- 1026612
TI  - Thrombocytopenia and cancer chemotherapy.

PMID- 1026613
TI  - Biologic energy crisis.

PMID- 1026614
TI  - Training black MDs.

PMID- 1026615
TI  - A hot wind from the North.

PMID- 1026616
TI  - Childhood immunizations.

PMID- 1026617
TI  - Influenza: the vaccines.
AB  - The extreme antigenic lability of the influenza A viruses accounts for the less
      than-ideal immune responses to them. With a possible swine flu pandemic in the
      offing, the "vaccine strategy" required is critical, particularly as the medical
      and public health communities in the United States embark on the first systematic
      attempt in history to blunt preemptively the impact of a pandemic.

PMID- 1026618
TI  - The case of the pulmonary mycetoma.

PMID- 1026620
TI  - How basic is basic science.

PMID- 1026619
TI  - Recognition and management of alcohol withdrawal syndrome.
AB  - Since alcoholism is not only widespread but often cryptic, the index of suspicion
      for the withdrawal syndrome in an unfamiliar patient should be high, particularly
      since failure to diagnose it is common and can eventuate fatally. Yet the signs
      and symptoms are consistent. A staged approach to the diagnosis is outlined and
      principles are given for the use of sedation and other therapeutic measures.

PMID- 1026621
TI  - Alcohol in toxic congestive cardiomyopathy.
AB  - Though ethyl alcohol is known to be one of the exogenous toxins that can directly
      damage the myocardium, nonalcoholic additives to alcoholic beverages (as well as
      poor nutrition or viral infection) may also play a role in cardiomyopathy. The
      authors note the interesting fact that, unlike the liver, the heart does not
      contain an alcohol dehydrogenase and thus lacks a possible protective mechanism
      against alcohol's toxicity.

PMID- 1026622
TI  - Influenza: the disease and its complications.
AB  - Among the complications (fortunately relatively few), pneumonias are by far the
      most common, with about one half resulting from pneumococcal invasion. In the
      acutely ill, multiple antibiotic therapy may have to be initiated pending
      definitive etiologic diagnosis. Also, in epidemic or pre-epidemic situations,
      special measures are advocated for hospitals, since influenza so rapidly becomes
      the dominant nosocominal infection.

PMID- 1026623
TI  - The case of the ulcerated colon.

PMID- 1026624
TI  - Insulin resistance in obesity.
AB  - The insulin resistance seen in obesity, which is characterized by elevated basal
      levels of insulin and an exaggerated insulin response to such stimuli as glucose
      ingestion, was thought to be related to another common characteristic of obesity-
      enlargement of the fat cell. Now, recent studies suggest that the enlarged fat
      cell is not the major source of insulin insensitivity in obesity and may, in
      fact, be the victim of the insulin-resistant state.

PMID- 1026625
TI  - The 'excellence' deception in medicine.

PMID- 1026626
TI  - A 'supreme court' for science?

PMID- 1026627
TI  - The management of obesity.

PMID- 1026628
TI  - The crazy, hairy, naked ape.

PMID- 1026630
TI  - Will the real Abraham Flexner please rise up.

PMID- 1026629
TI  - Common complaints of the elderly.

PMID- 1026631
TI  - Rational management of peptic ulcer disease.
AB  - If the goal of treatment is healing of the ulcer, then success is usually
      achieved - repeatedly. In order to avoid recurring episodes, it is essential that
      both the physician and the patient learn to regard the ulcer as the result of a
      chronic disease process. This means that management becomes a lifelong
      undertaking, with antacids and meals used according to schedules that keep
      gastric pH above ulcerogenic levels.

PMID- 1026632
TI  - The case of the echo-free cyst.

PMID- 1026633
TI  - Middle ear disease in children.

PMID- 1026634
TI  - Early warning.

PMID- 1026635
TI  - Surgical management of the elderly.

PMID- 1026636
TI  - Simultaneous occurrence of leprosy and pulmonary tuberculosis.

PMID- 1026637
TI  - Stevens-Johnson syndrome due to sulfuno (sulfamoxole).

PMID- 1026638
TI  - Simple lung function studies in silicosis amongst stone-cutters.

PMID- 1026639
TI  - Fibrolipoma of the bronchus.

PMID- 1026640
TI  - Recurrent spontaneous bilateral pneumothoraces.

PMID- 1026641
TI  - Adenylate cyclase of mycobacteria.

PMID- 1026642
TI  - Fate of abacillary pulmonary tuberculosis cases.

PMID- 1026643
TI  - Rifampicin--ethambutol in retreatment of pulmonary tuberculosis.

PMID- 1026644
TI  - Isonicotinic acid hydrazide (INH) induced syndrome of lupus erythematosus.

PMID- 1026645
TI  - Present day management of pulmonary tuberculosis.

PMID- 1026646
TI  - Cluster patterns of liver deposits in lung cancer.

PMID- 1026647
TI  - Giant intrathoracic fibroma.

PMID- 1026648
TI  - Ocular toxicity with ethambutol in tuberculosis patients.

PMID- 1026649
TI  - Cutaneous reactions to isoniazid.

PMID- 1026650
TI  - A method of processing to infer and achieve the required number of motile
      spermatozoa post thaw, per dose of frozen semen.

PMID- 1026651
TI  - A note on incidence of gestational estrus in buffaloes and cattle.

PMID- 1026652
TI  - Protein content in the semen of Nali and Corriedale breeds of rams.

PMID- 1026653
TI  - Studies on reproduction in camels (Camelus dromedarius). VII. The acid and the
      alkaline phosphatase activities of the seminal plasma.

PMID- 1026654
TI  - Effect of light on reproductive organs of prebueral male rats.

PMID- 1026655
TI  - Effect of off-season breeding on frequency of calving and calf mortality.

PMID- 1026656
TI  - A note on the effect of cooling rate, temperature of storage and packing material
      on the livability of ram spermatozoa.

PMID- 1026657
TI  - Sperm akinesia in a Hallikar bull.

PMID- 1026658
TI  - Influence of puberty and egg formation upon concentration of glycogen and total
      solids in the ovary and fallopian tube in WLH birds.

PMID- 1026659
TI  - Effect of season on the occurrence of oestrus and fertility in different breeds
      of sheep under semi-arid conditions.

PMID- 1026660
TI  - HSA'S.

PMID- 1026661
TI  - Malpractice: impact in California.

PMID- 1026662
TI  - All you ever wanted to know about PL 93-641.

PMID- 1026663
TI  - Clinical statistical observations on in-patients at neuropsychiatric clinic of
      Hiroshima University Hospital in the last 15 years (1959-1973).

PMID- 1026664
TI  - Effects of smoking on arterial blood gas tensions in relation to age.

PMID- 1026665
TI  - Primary clear-cell adenocarcinoma of the vagina. A case report.

PMID- 1026666
TI  - Effect of carbohydrates on growth inhibition by D-mannosamine of glucosamine
      requiring mutant cells of Chinese hamster lung cells.

PMID- 1026667
TI  - Parallel variation of homovanillic acid and 5-hydroxyindoleacetic acid in
      ventricular cerebrospinal fluid of man.

PMID- 1026668
TI  - Observations on spontaneous tumors in Wistar Furth strain rats.

PMID- 1026670
TI  - The Millis report and the real world.

PMID- 1026669
TI  - Sister chromatid exchanges in peripheral lymphocytes of atomic bomb survivors and
      of normal individuals exposed to radiation and chemical agents.

PMID- 1026671
TI  - Preoperative consultation.

PMID- 1026672
TI  - Need for retrievable record of what prescriber tells patient about a drug.

PMID- 1026673
TI  - DEA official explains stand on computerization of prescription records.

PMID- 1026674
TI  - Achieving patient cooperation in the treatment of hypertension.

PMID- 1026675
TI  - Nurse-pharmacist teams screen for hypertension.

PMID- 1026676
TI  - The malpractice crisis today: II. Medical-legal implications of prescribing.

PMID- 1026677
TI  - Some current problems in therapy.

PMID- 1026678
TI  - The pharmacist's responsibility to determine limitations on prescribing.

PMID- 1026679
TI  - Academic clinical pharmacology: a forecast for 1985.

PMID- 1026680
TI  - Organizing and managing for change in the health environment.

PMID- 1026681
TI  - Facing the inevitable: the physician's supportive role in the death of a child.

PMID- 1026682
TI  - Public standards for drugs: reflections on their use by the professions and
      industry.

PMID- 1026683
TI  - The differences in costs to hospitals and prices to patients for pharmaceutical
      products and services.

PMID- 1026684
TI  - Reorganizing the FDA: Editorial Board comments.

PMID- 1026685
TI  - A survey of pharmaceutical services to skilled nursing facilities.

PMID- 1026686
TI  - The neglect of the tease.

PMID- 1026687
TI  - Pharmacist improvement of patient compliance.

PMID- 1026688
TI  - Drug regulatory problems in smaller countries.

PMID- 1026689
TI  - Self-treatment with antibiotics.

PMID- 1026690
TI  - FDA problems with medications in the marketplace: II.

PMID- 1026691
TI  - FDA urged to establish "provisional approval" system for new drugs.

PMID- 1026692
TI  - One institution's rules for investigational drugs.

PMID- 1026693
TI  - Radiopharmacy: the challenge of an emerging specialty.

PMID- 1026694
TI  - Quality radiopharmaceuticals: a goal within reach.

PMID- 1026695
TI  - A system for the delivery of radiopharmaceutical services.

PMID- 1026696
TI  - Hazards of radioisotope storage: severe damage caused by two equipment failures.

PMID- 1026697
TI  - An efficient radiopharmaceutical record-keeping system.

PMID- 1026700
TI  - A form and procedure to streamline intravenous piggyback production.

PMID- 1026699
TI  - Physician-pharmacist conflict over drug therapy: a pharmacy policy statement.

PMID- 1026701
TI  - The interpretation of standards.

PMID- 1026702
TI  - Job satisfaction: a review.

PMID- 1026703
TI  - Pharmacy service in a 106-bed hospital.

PMID- 1026704
TI  - Medication error reports.

PMID- 1026705
TI  - Comparison of methods and costs of preparing intravenous piggyback solutions.

PMID- 1026706
TI  - The pharmacist as part of a rehabilitation team.

PMID- 1026708
TI  - Medication error reports.

PMID- 1026709
TI  - Curriculum development model for a coordinated undergraduate program in dietetics
      within a health science center.

PMID- 1026710
TI  - Allied health education: who is responsible? Who is to pay?

PMID- 1026711
TI  - Lifelong education: one health-care institution's approach.

PMID- 1026712
TI  - The utilization of the family in the rehabilitation of the chronically ill
      patient: some new perspectives for the allied health professional.

PMID- 1026713
TI  - A statewide cooperative approach to health manpower planning.

PMID- 1026714
TI  - Student selection: logic or lottery.

PMID- 1026716
TI  - Interpersonal skills development in health professions education.

PMID- 1026715
TI  - An interdisciplinary approach to the education of health professional students.

PMID- 1026717
TI  - Four characteristics for regional continuing education in medical allied health.

PMID- 1026718
TI  - Lifelong learning: a systematic approach to continuing education for schools of
      allied health.

PMID- 1026719
TI  - Transference and countertransference: implications for health care systems
      discontinuity.

PMID- 1026720
TI  - Measuring the costs of clinical education in departments utilizing allied health
      professionals.

PMID- 1026721
TI  - Health systems agencies: implications and prospects for the allied health
      professions.

PMID- 1026722
TI  - Core curriculum revisited.

PMID- 1026723
TI  - [Control-lateral sciatrica after surgery for herniated disk].
AB  - A study of 1,427 case records permitted the authors to discover 10 cases of
      reoperation for sciatica which appeared on the opposite side after removal of a
      dischernia. A new hernia was noted in 6 cases, whereas radiculitis of unknown
      origin, appeared to be responsible in 4 cases. The 10 patients who became cured,
      either after removal of the hernia, or after decompression through the foramin.
      These few cases, in fact rare, may be considered as relapses and thus poor
      surgical results. The provide a contribution to the understanding of
      intervertebral disc disease and raise an interesting medico-legal problem.

PMID- 1026724
TI  - [Indications and results of ileal neobladder during the development of cervix
      uteri cancer. Study of 32 cases].
AB  - 32 uretero-ileoplasties were carried out during the course of carcinoma of the
      uterine cervix, where therapeutic complications required an urinary by-pass
      operation. A trans-ileal by-pass to the skin ensured better renal function and
      comfort than that provided by a skin ureterostomy. The operation carried out in
      20 cases after curative radiotherapy,.remains possible with a reasonably low
      risk: 2 deaths. However, survival depends on the cancer. The operation is
      legitimate and advisable in urinary lesions due to treatment, but one wonders
      whether the operation is justified in cases where the carcinoma is inoperable.
      Present means of resuscitation made this surgery acceptable as far as the
      immediate risk is concerned and survival is undoubtedly comfortable. On may thus
      carry out again radical operations provided the lesions are limited and there is
      no fibropelvis after high dose cobalt-radiotherapy. But purely palliative trans
      ileal urinary by-pass operations remain debatable. Their indications depend on
      the general condition of the patient, the desire of the surgeon to operate and
      the functional result of these palliative operations should not be lost by
      carrying out too radical an operation which will shorten survival time.

PMID- 1026725
TI  - [Large esophagogastric caustic burns in the adult].
AB  - The authors treated, as an emergency, severe caustic burns in adults. They
      present 13 cases and discuss four deaths. Critical analysis of these
      observations,compared with the findings of pathology and in the literature,
      permit one to consider the therapeutic indications. The place of often major
      surgical operations is discussed in relation to further specialist investigations
      or the appearance of complications. The results are assessed in 8 patients who
      were followed up for a long period.

PMID- 1026726
TI  - [Ultrasonic aspects of abdominal abscesses and hematomas].
AB  - Abdominal ultrasonography often enables to display the fluid collection of an
      abcess or haematoma. This type of diagnostic procedure is most useful in a post
      operative period. The intestinal gases which stop the ultrasonic beam may be
      responsible for diagnostic failures. Positive results, which are the most
      frequent, are never the less precious to assess and decide a treatment policy.

PMID- 1026727
TI  - [Role of surgery in Hodgkin's disease. Round-table discussion].

PMID- 1026728
TI  - Tumor conference "8: squamous-cell carcinoma of the ear with regional metastases.

PMID- 1026729
TI  - Capsule dermatopathology: metastatic carcinoma from the breast vs. fibrosing
      (morphea-like) basal-cell carcinoma.

PMID- 1026730
TI  - Removal of a hairy nevus on the buttocks.

PMID- 1026731
TI  - Focus on melanoma: the therapeutic dilemma of lentigo maligna (Hutchinson's
      freckle).

PMID- 1026732
TI  - Diagnostic problems related to lesions under and around fingernails.

PMID- 1026733
TI  - Biopsy of the proximal nail fold in collagen diseases.
AB  - A research procedure used to study proximal rail folds in connective tissue
      diseases is described. The technique is simple and one that is suitable and
      agreeable to patients. It affords study of tissue from the proximal nail fold in
      three different ways, namely, light microscopy with histochemistry, electron
      microscopy, and direct immunofluorescence.

PMID- 1026734
TI  - Technique of biopsy of nails.

PMID- 1026735
TI  - Fingertip injuries and a plea for the nail.
AB  - Wounds involving the nail bed should be covered immediately by an autograft, a
      homograft or a heterograft to prevent dystrophy and loss of sensation. The
      author's technique in performing such grafts is described.

PMID- 1026736
TI  - Ungual prostheses.
AB  - Adhesives and surgical techniques are of limited value in the fixation of ungual
      prostheses. A finger-cover prosthesis that allows excellent fixation and good
      cosmetic result is described.

PMID- 1026737
TI  - The surgical treatment of axillary hyperhidrosis.
AB  - Surgical removal of the gland-bearing skin of the axillae as a reasonable
      management of axillary hyperhidrosis is described. The principle, according to
      the techniques of Skoog, is to peel back, not excise, the hairy zone of the
      axillary skin and to resect all the hyperfunctioning glandular layer on the
      deeper face of the dermis without damaging the dermal vascularization.

PMID- 1026739
TI  - A new disposable punch for use in hair transplantation.

PMID- 1026738
TI  - Replacement of scalp hair by attachment to suture implants.
AB  - A series of 1426 hair implants were performed by the author over a period of five
      years. Complications which were encountered are elaborated on in this article.
      The method is, nevertheless, an acceptable procedure.

PMID- 1026740
TI  - [Lipid makeup of Actinomyces olivaceus].

PMID- 1026741
TI  - [Existence of 2 types of substance transport in the small intestine based on the
      example of sugars and amino acids].

PMID- 1026742
TI  - [Effect of ration size and stock density on the variability of body length and
      certain plastic traits of red swordtail fry].

PMID- 1026743
TI  - [Comparative study of the antitumor action of a polyunsaturated fatty acid
      (linolenic) and of the products of its autooxidation].

PMID- 1026744
TI  - [Use of an electrophoretic esterase fractionating method for a study of their
      compartmentalization].

PMID- 1026745
TI  - [Lipid makeup of Crithidia oncopelti with a varying sensitivity to olivomycin].

PMID- 1026746
TI  - [Nocardia corallina pigment].

PMID- 1026747
TI  - [Direct demonstration of micelle formation in water-alcohol solutions of the
      tubular structures of Actinomyces roseoflavus var. roseofungini].

PMID- 1026756
TI  - [Pseudo-molar placenta with normal infant].

PMID- 1026757
TI  - [Relations between the oxytocin test and morphometry of the placenta].
AB  - We have studied placental morphometry after delivery in 23 cases in which the
      oxytocin challenge test was carried out towards the end of the pregnancy. Thus we
      have been able to compare the results of the two and establish details of
      placental measurement that have the greatest influence on its function. The
      following parameters seem to have the most direct influence, by statistical
      relationship, with placental insufficiency: the total surface of the villi, the
      concentration of villi per unit sectioned, the surface of fetal capillaries and
      the mean diameter of these capillaries. On the other hand the mean diameter of
      the villi and the number of capillaries per villus do not seem to have any
      relationship to function. These results bring further proof to our old ideas as
      to the value of placental morphometry and confirm the value of the oxytocin
      challenge test.

PMID- 1026758
TI  - [Peculiarities of hemostasis in the term newborn infant].
AB  - Haemostasis in the new-born is a product of various factors which are both
      qualitative and quantitative. The only factors that compare in levels and quality
      with those in the adult are factors V, VIII and XIII. They are alterations in the
      semi-analytical tests for coagulation except in the Stypven time. In contrast
      with this deficit shown up in haemostasis by global tests coagulation is normal
      and in truth there is hypercoagulability. Using Laurell's method of
      immunoelectrophoresis for levels of alpha 2 M high levels of this are shown
      contrasting with progressively lowered antithrombitic action. These paradoxes no
      doubt arise from the fact that neonatal haemostasis is analysed using
      standardised techniques and reactions which were developed for adult haemostasis,
      from which it is certainly as different as from those of other animals. Neonatal
      haemostasis is perfectly balanced in normal conditions. Important changes occur
      however in respiratory distress where there is a drop in factor V and soluble
      complexes appear, bringing about rough shapes suggestive of the subclinical
      syndrome of defibrination. This situation will be further developed in a
      forthcoming article.

PMID- 1026759
TI  - [Breast cancer and pregnancy. Apropos of 96 cases followed for 3 and 1/2 years at
      the Centre Leon Berard, Lyons].
AB  - 96 cases where cancer of the breast and pregnancy were associated have been
      studied at the Leon Berard Centre of Lyon with a follow-up of at least 3 years.
      Those patients who had a malignant tumour of the breast, which was treated, and
      then became pregnant (19 cases) were not made any worse (79 per cent survival in
      5 years). This was quite independent of the outcome of the pregnancy. On the
      other hand, those women (54 cases) in which the cancer was discovered and treated
      during pregnancy had a far worse prognosis (20 per cent survival in 5 years).
      This prognosis was made worse by the discovery of the cancer in the third
      trimester of the pregnancy, and by the presence of lymph node involvement, by
      termination of pregnancy and by weaning. When malignant tumours were discovered
      during breast-feeding or weaning (23 cases) the prognosis was equally bad (23 per
      cent survival in 3 years). The authors discuss the frequency of the association
      of cancer of the breast and pregnancy, as well as the different factors in the
      prognosis. They attempt to outline the management that should be carried out in
      the light of recent publications on this subject.

PMID- 1026760
TI  - [Study of 169 pelvic exenterations performed at the Centre Leon-Berard. 154
      patients surviving 5 years].

PMID- 1026761
TI  - [Statistical study of breech deliveries at the Maternite de Port-Royal from 1969
      to 1974].

PMID- 1026762
TI  - [Preliminary trials of an oral chemical contraceptive for men].

PMID- 1026763
TI  - [Prevention of prematurity by use of responses by the pregnant woman to the
      Coefficient of Premature Labor Risk Questionnaire (modification of Papiernik's
      CPLR)].

PMID- 1026764
TI  - [Induction of labor with PgF2 alpha. Clinical consequences. Tocodynamographic and
      electrohysterographic study].

PMID- 1026765
TI  - [Value of the rapid perfusion of Spasfon in high doses in dynamic dystocia and
      anomalies of dilatation].

PMID- 1026766
TI  - [Phytolastil in the treatment of weals of gravid origin].

PMID- 1026767
TI  - Nutrition labelling in the United States of America.

PMID- 1026768
TI  - Nutrition survey of an old people's home in a London borough.

PMID- 1026769
TI  - Dietitians of the future. 2: from the hospital to the community.

PMID- 1026770
TI  - Dietitians of the future. 3: thoughts of a science graduate.

PMID- 1026771
TI  - Problems presented by components of drug vehicles.

PMID- 1026772
TI  - Teeth, fluorine, and human nutrition.

PMID- 1026773
TI  - The moonstone: more about selenium.

PMID- 1026774
TI  - Psychological and social considerations in breast feeding.

PMID- 1026775
TI  - Breast feeding as seen in general medical practice.

PMID- 1026776
TI  - Difficulties and discouragements encountered by mothers.

PMID- 1026777
TI  - The practical management and establishment of breast feeding.

PMID- 1026778
TI  - Promoting breast feeding in Glasgow: 1. In the hospital.

PMID- 1026779
TI  - Promoting breast feeding in Glasgow: 2. In the community.

PMID- 1026780
TI  - The contribution of the health visitor.

PMID- 1026781
TI  - The lay organisations: 1. The Breastfeeding Promotion Group of the National
      Childbirth Trust.

PMID- 1026782
TI  - The lay organisations: 2. The Nursing Mothers' Association of Australia.

PMID- 1026783
TI  - The value of inversion radiography (invertography) in the assessment of anorectal
      malformation.

PMID- 1026784
TI  - Ileocystoplasty.

PMID- 1026785
TI  - Tuberculosis of spine (caries spine)

PMID- 1026787
TI  - The HMO and the private psychiatric hospital.

PMID- 1026786
TI  - Influence of funding on course of treatment: The fortuitous result of endsetting.

PMID- 1026788
TI  - Consumers and PL 93-641.

PMID- 1026789
TI  - Trans-cultural psychiatry: a statistical study of psychiatric treatment in India
      and the United States.

PMID- 1026790
TI  - Informed consent in the care of psychiatric patients.

PMID- 1026791
TI  - Studies on pulmonary complications due to cardiopulmonary bypass. I. Role of two
      traumatic blood elements in the lung of the dog with cardiopulmonary bypass.

PMID- 1026792
TI  - Studies on pulmonary complications due to cardiopulmonary bypass. II. Pulmonary
      changes after cardiopulmonary bypass in dogs.

PMID- 1026793
TI  - Chronic arsenical poisoning due to environmental pollution. Seven cases among
      inhabitants near an abandoned mine.

PMID- 1026794
TI  - Diagnostic significance of the evoked electrical responses in  neurological
      diseases. I. Somatosensory evoked responses.

PMID- 1026795
TI  - Diagnostic significance of the evoked electrical responses in neurological
      diseases. II. Orbicularis oculi reflex.

PMID- 1026796
TI  - Renal cell carcinoma with high level of serum alkaline phosphatase containing
      variant isoenzyme.

PMID- 1026797
TI  - A new mobile image intensifier and operating table to facilitate surgery.

PMID- 1026798
TI  - Study of some epidemiological changes in some areas under leprosy control
      programme in Maharashtra.

PMID- 1026799
TI  - Carrier state in leprosy.

PMID- 1026800
TI  - Childhood leprosy--study of prevalence rates and clinical aspects through surveys
      in Bombay.
AB  - This paper summarises the experience gained through extensive surveys of school
      children carried out in Greater Bombay over the past five years. The strikingly
      high proportion of children of 6 to 14 years age group suffering from leprosy
      attending the Acworth Leprosy Hospital and its peripheral clinic prompted these
      surveys. While surveys of 10% of child population attending randomly selected
      municipal schools revealed a general prevalence rate of 3 per 1000, there existed
      pockets of endemicity of the order of 10.8 per 1000, in some schools situated in
      the northern suburbs of the city. Even private schools catering to the not-so
      poor sections of the community showed prevalence rates of over 6 per 1000,
      confirming the hyperendemicity of leprosy in Bombay city, with no socioeconomic
      or age group immune from exposure. Clinical observations of 1265 leprosy cases
      identified in the course of the above surveys covering a total population of
      nearly 1.8 lakhs of school children are presented. 24.7% of the cases had either
      the potential to develop into progressive forms of leprosy in view of the
      multiplicity of lesions or were already in an advanced stage of the disease.
      Polyneuritic leprosy together with intermediate and lepromatous types
      representing 5.8% of all cases (24 cases were confirmed to be smear positive)
      belonged to the groups posing therapeutic as well as public health problems.
      Analysis of 953 cases with single lesions revealed greater frequency of
      distribution (58.4%) of patches in parts of the body which are generally covered.
      It is striking that 26.4% of the solitary lesions was found in the gluteal
      regions and thighs, emphasising the need for thorough examinations of these parts
      during surveys.

PMID- 1026801
TI  - Inactivation and relapse in bacterio-negative cases of leprosy under sulphone
      therapy: a 4 1/2 years follow-up.
AB  - Bacterio-negative leprosy cases become inactive in a short period under regular
      and adequate DDS treatment and this period is shorter in females. The progress is
      uneventful and is not influenced by factors like age, extent of disease,
      deformity status etc. The risk of relapse in bacterio-negative leprosy cases is
      not high though it increases with passing of time. The risk of relapse tends to
      be higher in cases with extensive disease.

PMID- 1026802
TI  - An evaluation of the self administration of DDS in Gudiyatham Taluk.
AB  - This study using the dapsone/creatinine (D/C) ratio was undertaken to find out
      how many of the patients attending the Village Clinics were actually taking the
      DDS tablets. The Urine D/C ratio was estimated in 35 patients who were receiving
      a supervised daily dosage of either 50 or 100 mgs of DDS. The D/C ratio was also
      estimated in 100 out patients who were on either 50 or 100 mgs of dapsone. It was
      determined that 72% of this group had taken DDS in the previous 24 hours. It was
      also seen that the 55 patients who were receiving 100 mgs of DDS had taken 79.3%
      of their dapsone dosage, and the 45 patients receiving 50 mgs of DDS had taken
      96% of their dosage.

PMID- 1026803
TI  - Pain and itch in leprosy.

PMID- 1026804
TI  - The pharmacological aspects and the therapeutic effects of clofazimine.

PMID- 1026805
TI  - An open trial with clofazimine in the management of recurrent lepra reaction
      using thalidomide as a control drug.

PMID- 1026806
TI  - Experiences with clofazimine therapy in leprosy.

PMID- 1026807
TI  - Clinical trial with clofazimine in leprosy.
AB  - This paper summarises our clinical experience with clofazimine in the treatment
      of 25 cases of reactive states of lepromatous and borderline leprosy and 7
      lepromatous patients not responding to dapsone. Corticosteroids, which had to be
      given for the control of reactions, could be withdrawn and daspone therapy
      reintroduced during the period of administration of clofazimine. A schedule for
      the management of moderately severe reactions is recommended. The results of
      clofazimine treatment were also equally impressive in the group of patients,
      possibly harbouring dapsone resistant bacilli (in view of their lack of
      improvement in spite of administration of dapsone under controlled conditions).
      Clinical regression was associated with a fall in the mean levels of
      morphological index from 6.8 to 0.5. The need to realise the real indications of
      this highly useful drug in the treatment of leprosy is stressed.

PMID- 1026808
TI  - Experiences in treatment of histoid cases with clofazimine.

PMID- 1026809
TI  - Experience with the combination of clofazimine (Lamprene) and long-term steroid
      therapy in the treatment of leprosy.
AB  - A study was undertaken in 14 patients and 20 controls to find out if Lamprene can
      prevent a flare-up of the infection with Myco. leprae in patients who are on long
      term steroid therapy on account of persistent reaction or neuritis. All patients
      were lepromatus (LL). The average duration of treatment was 21 months for the
      patients on Lamprene combined with steroids and 22 months for the patients on
      Lamprene only. There was no significant difference between the two groups in the
      reduction of either the MI (morphological index) or BI (bacteriological index).
      It appears that long-term steroids therapy has no adverse effect on the
      bacteriological decline in lepromatous patients provided that they are treated
      with Lamprene at the same time.

PMID- 1026810
TI  - Side effects of clofazimine therapy.
AB  - 84 patients of leprosy including 15 female patients were treated with Clofzimine
      on a predetermined dosage regimen. 76 of these were cases of recurrent lepra
      reaction; 4 cases of proven DDS resistance, 3 of these being complicated by lepra
      reaction; and 4 were cases of reactional state in Borderline leprosy near the
      lepromatous end of the spectrum. The common side effect in all cases consisted of
      red and dark skin pigmentation of varying intensity occuring within 10 weeks of
      the commencement of therapy. The intensity of the colour was proportionate to the
      density of the infiltration. Ichthyosis occurred in 66.6% of cases. While the
      pigmentation was accepted by the patients in general, 10% of the patients
      considered ichthyosis as stigmatising. While side effects like anorexia,
      diarrhoea, enlargement of lymph glands and liver, corneal xerosis and loss of
      weight were self correcting, severe gastrointestinal manifestation, i.e. severe
      abdominal pain, vomiting and diarrhoea were observed in 9 patients, 5 of whom
      were females. Mortality was high in the females. On an incidental finding the
      Isonizair reduced the severity of the manifestations, it was supplemented in 10
      cases on Clofazimine therapy and was found to minimise the side effects and the
      pigmentation due to Clofazimine. Hydration therapy for the ichthyosis and
      instillation of normal saline and liquid paraffin for corneal xerosis were found
      to be very useful.

PMID- 1026811
TI  - Quantitative estimation of clofazimine in tissue.
AB  - The histological examination and the chemical estimation of clofazimine in the
      organs removed at autopsy of a patient receiving the drug indicated the
      accumulation of the drug in the organs of the reticulo-endothelial system and
      those having a large number of macrophages. The clofazimine levels in the skin
      from patients receiving the drug and those in whom the drug had been stopped for
      different periods of time were compared. The skin levels of clofazimine bore a
      direct relationship to the size of the granuloma. A slow elimination of the drug
      from the tissues was indicated by the presence of traces of the skin tissue even
      1-2 years after stopping the drug. The clinical implication of these findings are
      discussed.

PMID- 1026812
TI  - Development of plantar ulcers in 3 groups of patients with plantar anaesthesia.

PMID- 1026813
TI  - A study of management of post-operative complications in intrinsic replacement of
      hand operations in leprosy through physiotherapeutic method.

PMID- 1026814
TI  - An analysis of causes of injuries in workers with leprosy and suggestions for
      preventive measures.
AB  - A study of 20 workers undergoing social and vocational rehabilitation and of 30
      patients receiving treatment in Ulcer Ward reveals bio-social data and endeavours
      to uncover the causes of injuries to anaesthetic areas. Suggestions are put
      forward for prevention of injuries which often lead to ulcers and these
      suggestions are examined in the light of short trials of various methods.

PMID- 1026815
TI  - Surgical management of acute trunk nerve neuritis in leprosy.

PMID- 1026816
TI  - A preliminary clinical trial of rifampicin in leprosy.
AB  - A single dose of 1500 mg. of rifampicin failed to make the lepromatous leprosy
      patients non-infective by using mouse foot-pad technique. It is essential to
      extend the trial further.

PMID- 1026817
TI  - Clinical recognition and therapeutic confirmation of sulphone resistant leprosy
      patients.

PMID- 1026818
TI  - Morphological index in untreated cases of leprosy.

PMID- 1026819
TI  - Ways and means of proper implementation of National Leprosy Control Programme.

PMID- 1026820
TI  - National Leprosy Control Programme--a critical assessment.

PMID- 1026821
TI  - Assessment of leprosy control work of the Santhal Pahadia Seva Mandal, Deoghar.

PMID- 1026822
TI  - Importance of systematic school survey in urban leprosy control.

PMID- 1026823
TI  - Case detection through school surveys in Greater Bombay.
AB  - Of the 55,502 students examined 214 were found to be suffering from leprosy, the
      case-detection rate being 3.9 per 1000. Age of the students showed no relation to
      the occurrence of leprosy. Sex of the student was significant. Leprosy was more
      common among the male students. Leprosy rate amongst Tamil and Urdu speaking
      students was significanlty more than amongst Marathi and other language groups.
      98% of cases were tuberculoid, 2% cases intermediate and nil lepromatous. 4% of
      cases were bacteriologically positive. Over 99% of cases were without deformity
      86% of cases were in early stages. In a significant number of leprosy cases the
      single lesion (presumably initial lesion) was on the covered parts of the body.

PMID- 1026824
TI  - Rehabilitation of leprosy patients--a realistic approach.

PMID- 1026825
TI  - Health education in rural area.

PMID- 1026826
TI  - Role of health educator in leprosy control.

PMID- 1026827
TI  - The field problems of leprosy workers.

PMID- 1026828
TI  - Field problems of leprosy workers in India.

PMID- 1026829
TI  - Study on defaulters in the treatment of leprosy.

PMID- 1026830
TI  - Integrated surveys as a tool for early case detection in leprosy control
      programme.
AB  - A project for total leprosy case detection particularly early leprosy cases was
      undertaken in Wardha District which has a rural population of about 6 lacs in 905
      villages, through an integrated survey with the help of all health workers like
      Leprosy Technicians, Sanitary Inspectors, Co-ordinators, Malaria Workers,
      Smallpox Vaccinators and Auxillary Nurse Midwives. The training given to the Non
      Leprosy Health Worker was for a period of 3 days making them just fit to suspect
      all leprosy cases. The final diagnosis was to be made by the fully trained
      Leprosy Technicians. The surveys were conducted in batches of 3 to 4 workers.
      Surveys were conducted for 4 weeks at a stretch and working for 5 days every
      week. Every year two such integrated surveys were conducted. From November 1973
      to December 1975, four such surveys were undertaken. During the other period,
      Leprosy Technicians were conducting the normal surveys. It was found that through
      these integrated survey it is possible to undertake the survey of all the
      villages once in two years and the case detection rate at the end of the 4th
      survey was found to be 85.5% of the estimated cases in the rural areas. Normally,
      it would have taken about 5 years to complete the survey of all the villages by
      the Leprosy Technicians alone, and the case detection rate could not have been
      more than 70 to 75%. Through this programme, Leprosy patients in every early
      stages have been detected. The paper discusses the methods, planning and the
      results obtained.

PMID- 1026831
TI  - [Clinical and epidemiological characteristics of pertussis in our patients].

PMID- 1026832
TI  - [Importance of the foramen epiploicum Winslowi in x-ray examinations of the
      gastrointestinal tract].

PMID- 1026833
TI  - [Clinical diagnosis and therapy of chronic stomach diseases].

PMID- 1026834
TI  - [Report of a case of essential atrophy of the iris with secondary glaucoma].

PMID- 1026835
TI  - [Occurence of a case of nephrotic syndrome in the acute phase of infectious
      hepatitis].

PMID- 1026836
TI  - [Pneumonias on the territory of the Listica community during the last 3 years
      (1973,1974,1975)].

PMID- 1026837
TI  - [Ambulatory treatment of 30 women-patients using the Guber mineral water].

PMID- 1026838
TI  - [The function of public health of services in hygiene and epidemiology].

PMID- 1026839
TI  - Constituents of West African medicinal plants. XVI. Griffonin and Grriffonilide,
      novel constituents of Griffonia simplicifolia.

PMID- 1026840
TI  - The cytotoxic flavonoids of Lychnophora affinis.

PMID- 1026841
TI  - Thalidine, a new isopavine alkaloid from Thalictrum dioicum.

PMID- 1026842
TI  - Rutaceous constituents. Part 7. The total synthesis of 11-Hydroxynoracronycine, a
      constituent of Atalantia ceylanica and a metabolite of acronycine in the guinea
      pig.

PMID- 1026843
TI  - Dihydroxyphysalin B: a new physalin from Physalis minima leaves.

PMID- 1026844
TI  - A review of some biologically active compounds isolated from plants as reported
      in the 1974-1975 literature.

PMID- 1026845
TI  - Isolation of 3,6-dimethoxy-4',5,7-trihydroxyflavone from Acanthospermum
      glabratum.

PMID- 1026846
TI  - Alkaloids of Annonaceae. XIV. Identification of canangine and eupolauridine, new
      alkaloids with a naphthyridine nucleus.

PMID- 1026847
TI  - Cactus alkaloids. XXX. N-Methylated tyramines from Trichocereus spachianus. T.
      candicans, and Espostoa huanucensis.

PMID- 1026848
TI  - Mass fragmentographic identification of O-Methylcorpalline in Pilosocereus
      guerreronis.

PMID- 1026849
TI  - Molecular weight variation among bacterial flagellins.
AB  - The molecular weights of flagellins from 29 bacterial strains from 11 genera were
      investigated using the technique of polyacrylamide gel electrophoresis in the
      presence of sodium dodecyl sulphate. The molecular weights range from 28,600 for
      Bacillus sphaericus to 63,200 for one strain of Escherichia coli. Variation in
      molecular weight was observed not only between genera but also between different
      species of a genus and different strains of a species.

PMID- 1026850
TI  - Purification and location of the major glycoprotein of vaccinia virus.
AB  - A glycoprotein component of vaccinia virus was extracted with a non-ionic
      detergent NP-40 (Nonidet P-40) and purified by gel chromatography. The single
      antigen extracted by the detergent had a molecular weight estimated between
      100,000 and 200,000 daltons. This glycoprotein was found to contain less than 1%
      hexosamine which would correspond to 5--10 sugar residues per molecule.
      Antibodies produced against this glycoprotein were able to neutralize vaccinia
      virus. Using immunoelectron microscopy, this molecule was found to be located in
      the outer layer of the virion. These results further suggest that this protein
      called complex E (for external) is a surface component of vaccinia virus.

PMID- 1026851
TI  - Topological features of membranes from Staphylococcus aureus and Acholeplasma
      laidlawii.
AB  - Topological and ultrastructural features of membranes from walled and wall-less
      bacterial cells were compared by examining membranes from Staphylococcus aureus
      and Acholeplasma laidlawii. Osmotic lysis of protoplasts of S. aureus or cells of
      A. laidlawii produced membrane vesicles or large membrane fragments, but alumina
      grinding or sonication of these protoplasts or cells produced much smaller
      particles whose morphologic origin was difficult to determine. Disrupted
      membranes from either organism were covered with ribosomes from 15 to 30 nm
      diameter adhering almost exclusively to the inside of the vesicles or fragments.
      Membranes were similar in thickness and possessed 5--6 nm globular knobs which
      were not on stalks, not highly ordered, and easily differentiated from the
      negative-stained background. Although the globular knobs were regularly visible
      on membrane sheets from S. aureus, they were seen on A. laidlawii membrane
      vesicles only rarely unless the membrane vesicles were treated with 0.01% saponin
      or 90% (v/v) cold acetone, which extracted lipids and glycolipids from the
      membrane vesicles. Membrane vesicles from lysed cells of A. laidlawii showed a
      widespread distribution of circular pits about 10 nm deep and at least 20-30 nm
      across, not seen in lysed protoplast membranes of S. aureus.

PMID- 1026852
TI  - The effect of cigarette smoke on aryl hydrocarbon hydroxylase activity and
      cytochrome P450 content in rat liver and lung microsomes.
AB  - Levels of activity of the enzyme aryl hydrocarbon hydroxylase and cytochrome P450
      have been estimated in lung and liver of rats exposed to graded doses of
      cigarette smoke and in human bronchial mucosa of smokers, non-smokers and
      patients with lung cancer. Exposure of rats to smoke of four cigarettes increased
      both hepatic and pulmonary aryl hydrocarbon hydroxylase activity. Exposure to
      smoke of four cigarettes daily for seven and 14 days did not result in higher
      aryl hydrocarbon hydroxylase levels in the liver than one day's exposure, but in
      the lung longer exposures caused greater increases in enzyme activity. Injection
      of benzo(a)pyrene at two dose levels caused a much greater increase in both liver
      and lung aryl hydrocarbon hydroxylase than smoking. The lower dose maximally
      stimulated the enzyme in both organs. The changes in aryl hydrocarbon hydroxylase
      activity were accompanied by significant increases in both liver weight and the
      cytochrome P450 content of liver microsomes but the increase in cytochrome P450
      did not parallel those in aryl hydrocarbon hydroxylase activity. Of 40 surgical
      and autopsy specimens of human lung and tracheal mucosa from smokers, non-smokers
      and cancer patients, only one was found to have detectable aryl hydrocarbon
      hydroxylase activity. The relationship between aryl hydrocarbon hydroxylase
      induction by cigarette smoke in human tissues and the development of bronchogenic
      carcinoma in smokers remains unclear.

PMID- 1026853
TI  - In vitro inhibition of aryl hydrocarbon hydroxylase by heavy metals.
AB  - Inhibition of mouse hepatic aryl hydrocarbon hydroxylases (AHH), microsomal mixed
      function oxidases was obtained with five bivalent metal chlorides. Concentrations
      ranged from 10(-6) to 10(-1) m. The enzyme system was induced by an
      intraperitoneal injection of a trioctanoin solution of 3-methylcholanthrene into
      C57B1/6J mice 24 hours before the hepatic AHH was measured. Activity was
      calculated as: ng of 3-hydroxybenzo(a)pyrene formed in 20 min at 37 degrees C per
      mg of protein. Cadmium was the most inhibitory of the metals tested. Zinc
      inhibited the enzyme system more than iron, manganese, or nickel. At 10(-4) m,
      ferrous ion slightly stimulated the activity, but at 10(-5) and 10(-3) m, it was
      inhibitory. Manganese failed to stimulate the enzyme activity as reported by
      others.

PMID- 1026854
TI  - C'3 participation in the rejection of some experimental tumors.
AB  - The possibility that C'3 participates in tumor rejection was investigated in
      DBA/2 mice previously immunized against L1210 leukemia and in Swiss mice
      previously immunized against Ehrlich's adenocarcinoma. In both the cases, animals
      treated with an appropriate dose of cobra venom factor to produce a C'3 depletion
      for some days after the tumor challenge, developed the neoplasia and had a
      mortality rate analogous to that of non-immunized animals. Studies on the
      peritoneal washing cells obtained at different times after the challenge revealed
      that in C'3 depleted immunized mice IgM are present on lymphocytes, macrophages
      and tumor cells, as in the immunized controls, but no contract between the cells
      and no macrophage phagocytosis were observed and the number of tumor cells
      increased progressively. These findings indicate that C'3 is critically involved
      in the rejection of the experimental tumors considered.

PMID- 1026855
TI  - On the relationship between the activity of acetylation, growth of experimental
      tumors and efficacy of their suppression by hydrazine sulphate.
AB  - The growth of experimental tumors was found to involve an intensification of
      acetylation of sulphadimidine. Inhibition of carcinosarcoma Walker-256 by 88% and
      sarcoma-180 by 36% on treatment with 60 mg/kg body weight of hydrazine sulphate
      was followed by decreases in the rate of acetylation of 39.4 and 29.4%,
      respectively. When treatment failed to suppress tumor growth (sarcoma-45),
      acetylation level showed no decrease. The results point to a correlation between
      growth of tumors and their inhibition on the one hand and the level of
      acetylation on the other.

PMID- 1026856
TI  - Experimental heterotransplantation of Detroit-6/VA/carcinomatous cells into the
      eyeball of hypercholesterolemic rabbits.

PMID- 1026857
TI  - The thiamin status of early cancer patients with particular reference to those
      with breast and bronchial carcinomas.
AB  - The thiamin status of early bronchial and breast carcinomas has been assessed
      using "thiamin pyrophosphate" (TPP) stimulating effect of transketolase enzyme
      activity. The TPP stimulating effect was found to be greater in a high proportion
      of the cancer patients than in normal subjects, suggesting that these patients
      may be at risk of thiamin deficiency. The urinary excretory level of thiamin was
      high in the cancer patients; it is, therefore, unlikely that the biochemical
      deficiency of the vitamin was due to lack of the vitamin intake. It is, however,
      possible that the cancer patients were unable to convert thiamin to thiamin
      pyrophosphate, the active form of the vitamin.

PMID- 1026858
TI  - Generalized osteoblastic bony metastases from medulloblastoma.
AB  - Osteoblastic bony metastases were observed in a case of medulloblastoma three
      years after surgery and radiation treatment. There was clinical response to COP
      therapy (cytoxin, oncovin, prednisone). Radiographic and isotopic bone scan study
      showed uniform increase in bone density. Serum calcium and phosphorous and acid
      phosphatase levels were normal. Alkaline phosphatase was elevated and declined
      with therapy without change in the bone appearance. This suggested an increase in
      bone deposition activity. However, no increase in calcitonin level was detected
      either during active disease or following a chemotherapy-induced remission.

PMID- 1026859
TI  - Enhancement of the antitumor effect of 1,3-bis(2-chloroethyl)-l-nitrosourea
      (BCNU) by phenylethylbiguanide (phenformin).
AB  - Phenlethylbiguanide (phenformin) a commonly used antidiabetic medication has been
      found to enhance the antitumor effect of 1,3-bis(2-chloroethyl)-l-nitrosourea
      (BCNU) in advanced subcutaneously implanted murine L1210 leukemia. Enhancement
      required two doses of phenformin given twelve to 18 hours apart, the treatment
      starting either before or after BCNU administration. With BCNU alone median
      survival (MS) was 18 days with 5% cures. BCNU plus phenformin, in optimal dose
      and schedule, gave a MS of 25 days with 29% cures. Th mechanism of action of
      phenformin is unknown but may involve several established metabolic effects of
      this drug.

PMID- 1026860
TI  - [Patterns of mechanical stress at the successive stages of early development of
      frog].
AB  - The immediate relaxation deformations have been studied in the embryonic frog
      tissues from the late blastula stage till the early tail bud stage. As a result,
      the maps of mechanical stresses were constructed which were characterized by the
      existence of distinct tension-lines dissecting the embryonic tissues (cross
      lines). A few discrete moments of development were established when new cross
      lines formed or the previous ones disappeared; they are separated by the
      topologically invariant periods of development. The cross-lines play an important
      role in morphogenesis in that they determine the ways of active cell migration
      and trace the boundaries between different anlages. The orientation of the cross
      lines coincides, as a rule, with the direction of predominant tension of tissues
      during the preceding topologically invariant period of development.

PMID- 1026861
TI  - [Proliferation of the cells of iris and pigment epithelium of the retina in the
      early periods after removal of the lens and iris in Spanish newts].
AB  - It has been shown by means of autoradiography that following the simultaneous
      removal of lens and retina in the eyes of adult ribbed newts (Pleurodeles
      waltlii) the proliferative processes related to the regeneration of retina,
      rather than lens, are most active at the early stages of eye restoration. During
      the lens regeneration in the absence of retina, the proliferation of the cells of
      pars iridica of the dorsal iris zone, a source of lens regeneration, is delayed,
      possibly due to the increase of the duration of mitotic cycle of these cells.

PMID- 1026862
TI  - [Sex differences in the secretory activity of the gonads and in their sensitivity
      to gonadotropins in early ontogenesis of rats].
AB  - The secretion of estrogens by the ovaries of foetal (15-19 days of gestation) and
      newborn rats in organ cultures was not detected by fluorimetry when the ovary was
      taken prior to the onset of folliculogenesis. The time schedule of the process of
      folliculogenesis in organ culture corresponded to that in vivo. Estrogens were
      detected in the medium when folliculogenesis was fully established in organ
      cultures. The secretion began spontaneously and was not affected by the addition
      of gonadotropins to the medium. On the contrary, the secretion of androgens by
      the testes of foetal (17-19 days of gestation) and newborn rats in organ cultures
      was constantly detected by the competitive protein-binding assay. The addition of
      gonadotropins to the culture medium increased the level of androgen secretion by
      foetal and newborn rats.

PMID- 1026863
TI  - [Ratio of concentration of ions of uni- and bivalent metals in the tissues of
      developing chick embryos and 1-day-old chickens].
AB  - The ratio of concentrations Na+/K+ decreases in the brain and liver and increases
      in the cardiac muscle during the chick embryogenesis. The maximum concentration
      of Ca2+ was noted in the tissues under study on 14th day of chick embryonic
      development and its content decreased reliably at the subsequent stages. The
      concentration of Mg2+ in the tissues under study decreased during the
      embryogenesis as well.

PMID- 1026864
TI  - [Desmosomes of follicular cells and C-cells in the thyroid gland of rats].
AB  - Well developed desmosomes can be seen between the C-cells and follicular cells in
      the rat thyroid gland. They are structurally similar to the desmosomes at the
      boundaries of homotypic cells. This observation speaks in favour of the
      development of C-cells from the initial cells of thyroid embryonic analage.

PMID- 1026865
TI  - [Growth of the eye and pigment epithelium of the retina during postnatal
      development of rats].
AB  - By the weight changes, the rat's eye grows during the whole life, whereas its
      scleral sector with the area equal to that of pigment epithelium of the retina
      grows most intensively between the 2nd and 5th days after birth. During this
      period, its weight attains half of the value characteristic of the scleral sector
      for one year old rats. This period of growth of the scleral sector coincides with
      the previously established peak of proliferative activity and appearance of first
      binuclear cells in the pigment epithelium. From the 5th day till the 12th month
      after birth, the weight of scleral sector increases twice and its area 6 times.
      This suggests that the mechanical tension of the scleral sector walls is one of
      the factors of growth of this eye part. On the basis of comparison of the scleral
      sector growth, changes in proliferative activity and number of polyploid cells in
      the pigment epithelium of the central zone of fundus oculi, the following
      periodization of the life cycle of cell population of the pigment epithelium is
      proposed: (1) from birth till the 15th day--period of principal determination
      (the number of binuclear tetraploid cells attains 80%), (2) from the 15th day
      till, at least, the 5th month--period of stabilization, (3) after 5 months-
      period of senescence characterized by the accumulation of highly ploid tri- and
      tetranuclear cells; its lower limit is not clearly defined.

PMID- 1026866
TI  - [Number of whorls and umbel rays in Acetabularia].
AB  - It was found in the proposed model of morphogenesis of Acetabularia that the
      number of whorls N (as well as the number of umbel rays) depends on the degree of
      mechanical instability of the deforming cell wall (the greater is instability,
      the higher is the value N). The genetic control of final morphogenetic processes
      can be realized by setting definite physical conditions and properties. The
      theoretical estimates of N carried out for different cases agree fairly well with
      the experimental data obtained.

PMID- 1026867
TI  - [Study of temperature-sensitive mutations in the virilis group of Drosophila. 4.
      Phenogenetics of a temperature-sensitive mutation affecting the development of
      imaginal discs in Drosophila virilis Sturt].
AB  - The phenogenetics of a new temperature-sensitive mutation diskless-ts (dl-ts, 2nd
      chromosome) has been studied in D. virilis. The rearing of larvae from the 1st
      instar at the temperature 31 degrees resulted in the complete or partial arrest
      of the development of imaginal discs and, consequently, the death of larvae prior
      to the pupation, at the prepupa stage. The change of temperature from 25 to 31
      degrees during the second half of development in the 3rd instar affects the
      differentiation of imaginal discs. Some organs differentiate completely or
      partially (eyes, wings, legs) whereas the rest do not develop at all. The
      sensitive period embraces the whole larval development till the beginning of
      pupation.

PMID- 1026868
TI  - [Reactivation of the nuclei of reticulocytes and erythrocytes in heterokaryons].
AB  - The reactivation of the nuclei of erythrocytes, reticulocytes and bone marrow
      cells has been studied by means of hybridization of the pigeon erythroid cells
      with the human embryonic cells A1. The process of reactivation of the erythroid
      nucleus was shown to depend on the stage of erythroid cell differentiation. The
      nuclei of cells at the earlier stages of differentiation give a higher percentage
      of heterocaryons (40%, 70%) than those of more mature cells (9%). The activated
      nuclei of immatur cells formed nucleoli already 24 hrs, whereas those of mature
      erythrocytes only 3-5 days after the cell fusion.

PMID- 1026869
TI  - [Reorganization of the nervous system during regeneration in Dugesia tigrina].
AB  - The normal structure of the nervous system in Dugesia tigrina Girard and the
      total morphodynamics of the nervous system during regeneration have been studied
      by means of choline esterase assay. The nervous system reacts to local damages of
      the planarian body; accumulations of nervous elements form in the wound region.
      Following the transverse cut of a planarian, the regeneration of the nervous
      system is not reduced to the completion of lacking parts. In this case (as well
      as in that of asexual reproduction) the nervous system manifests a considerable
      morphological lability and undergoes morphological rearrangements accompanied by
      the appearance of additional, frequently unpaired, nerve trunks. The data
      obtained are to be taken into account in neurobiological studies on planarians.

PMID- 1026870
TI  - [Time of the action of genes controlling the activity of aldolase in embryonal
      development of groudling].
AB  - The time of action of the genes controlling the decrease of aldolase activity (21
      23 hrs of development) and its subsequent increase (23-36 hrs) was determined by
      means of inactivation of the nuclei by actinomycin or heavy doses of irradiation
      at succesive developmental stages. There exist two distinct periods of gene
      activity; the former (15-18 hrs) determines the rapid fall of maternal aldolase
      activity and the latter (21-27 hrs) its subsequent replacement by embryonic
      aldolase. This result is confirmed by the data concerning the changes in aldolase
      heat resistance in the hybrids of the loach and tropical cyprinids. The genes
      controlling the synthesis of the new aldolase and the morphogenesis which takes
      place at the same developmental stages are functioning at different times, i.e.
      the biochemical and morphological differentiations may occur relatively
      independently.

PMID- 1026871
TI  - [Spontaneous polyploidy in laboratory mice. Embryological and cytogenetic
      analysis].
AB  - The developmental patterns of mice with spontaneous genomic aberrations at the
      pre- and post-implantation embryonic stages have been studied. The frequency of
      spontaneous triploidy varies in different strains from 1.7 to 5.8%. Digeny is the
      principal cytogenetical mechanism for triploidy. The triploid embryos of all the
      strains under study are characterized by the total delay of development already
      at the blastocyst stage. The most of triploids die at the stages of neurula and
      beginning of active organogenesis. A few triploids are resorbed during
      placentation. In the CBA mice, the triploidization results in the characteristic
      syndrome: disproportionally reduced amniotic vesicle, hypertrophied allantoic
      rudiment, reduction of neural plate, absence of head folds, notochord and
      mesenchyme. The spontaneous tetraploidy in mice occurs very rarely and is
      accompanied by severe developmental defects already at the preimplantation
      stages.

PMID- 1026872
TI  - [Study of nucleic acid synthesis in rat embryos in relation to phase-specific
      characteristics of teratogenic effect of chloridine].
AB  - The maximal rate of incorporation of 32P-phosphate, 14C-formate and 14C-thymidine
      in DNA was recorded on the 13th day of development in the rat embryos and that of
      14C-formate and 32P-phosphate in RNA and nucleotides of the acid-soluble fraction
      on the 12th day. The maximal incorporation of 14C-formate was recorded later: on
      the 15-16th days. Chloridin inhibited the incorporation of 14C-formate in DNA at
      all developmental stages, irrespective of the sensitivity of embryos to its
      teratogenic effect. The period of the maximal rate of DNA synthesis coincides
      with that of highest teratogenic activity of the drug. A suggestion is put
      forward to the effect that quantitative differences in the intensity of DNA
      synthesis at different stages of organgenesis provide one of the main causes of
      differential sensitivity of embryos to the teratogenic effect of inhibitors of
      nucleic acid synthesis.

PMID- 1026873
TI  - [Ultrastructural analysis of the effects of dominant cataract-Fr gene in mouse
      embryos].
AB  - An electron microscope study of lenses in 11--15 and 17 days old embryos of mice
      homozygous by dominant cataract-Fr (CatFr) gene has shown that ultrastructural
      changes in the nuclear envelope are the earliest expression of the mutant gene.
      The primary lens fibers of 12 days old embryos CatFr/CatFr, unlike those of the
      normal ones, are characterized by the decrease in the number of nuclear pores,
      evagination of the outer nuclear membrane, marked and unequal extension of
      perinuclear space which connects itself with the endoplasmic reticulum cisternae.
      In 14 days old embryos breaks in the outer nuclear membrane and evaginations in
      the inner one, fusion of nuclear membranes and breaks of the nuclear envelope are
      observed and resulted in the release of the nuclear contents with the nucleolus
      in the cytoplasm. Similar ultrastructural changes are characteristic also of the
      nuclei of secondary lens fibers at a comparable stage of differentiation. The
      destructive changes of nuclei are accompanied by the degeneration and
      autophagocytosis of cellular organelles and matrix.

PMID- 1026874
TI  - [Ultrathin structure of normally growing and regenerating cells of Acetabularia
      mediterranea].
AB  - The ultrastructure of nucleus and cytoplasm in regenerating cells of Acetabularia
      mediterranea differs from that in normally growing ones: the nucleus of
      regenerating cells form numerous outgrowths; the cortical layer of nucleolus
      disintegrates markedly; the emission of nucleolar material in the nucleoplasm is
      observed. In the cytoplasm the portion of active chloroplasts increases and a
      great number of tubular fibrils appears. In the cytoplasm of regenerating cells
      the Golgi dictyosomes occur more frequently and the vesicles at their ends are
      larger than in that of normally growing cells. The changes of macromolecular
      organization of the nucleus and cytoplasm in question observed at the earlier
      stages of regeneration (2--12 hrs) suggest the increase of metabolic activity of
      cells.

PMID- 1026875
TI  - [Species specificity of morphogenetic factors of Acetabularia, localized in the
      cytoplasmic zone adjacent to the cell membrane].
AB  - The species specificity of the factors controlling the cap development was
      established in the experiments with the transplantation of both the intact and
      centrifuged in the basal direction apical regions of Acetabularia meditteranea on
      nuclear basal regions of A. crenulata. These factors are found at the stage of 72
      hrs of regeneration primarily in the cytoplasmic zone adjacent to the cell
      membrane which is not displaced during centrifugation. Using direct measurements
      and radiochemical method, we have shown that the accumulation of proteins
      proceeded in this zone due, mainly, to their transition from the cytoplasmic zone
      displaced during centrifugation.

PMID- 1026876
TI  - [RNA synthesis in embryogenesis of Drosophila virilis].
AB  - The synthesis of different RNA fractions labelled by 3H-uridine has been studied
      at different developmental stages in Drosophila virilis by means of thermal
      phenol extraction and chromatography on oligo-alphaT-cellulose. There are two
      periods of intensive synthesis of poly-A containing (messenger) RNA in the course
      of embryogenesis. The former (6--12 hrs) is the period of gastrulation and
      stomodeum development and the latter (15--21 hrs) is the period of intensive
      differentiation of larval organs. The synthesis of poly-A free RNAs predominates
      at the stages of blastoderm (2--5 hrs) and mesoderm segmentation and embryo
      shortening (12--15 hrs).

PMID- 1026877
TI  - [Change in testosterone content in the testes and peripheral blood in male rats
      during postnatal development].
AB  - Changes in testosterone content have been studied in the testes and peripheral
      blood in male rats from the 1st till the 42nd day after birth. The correlation
      was established between the level of luteinizing hormones in the blood and that
      of testosterone in the testes during the first 5 days after birth.

PMID- 1026878
TI  - [Formation of tetraploid nuclei in regenerating rat liver].
AB  - The proliferation of binucleated cells in the liver of young Wistar rats after
      partial (2/3) hepatectomy was studied by means of autoradiography and
      cytophotometry. The analysis of the kinetics of 3H-thymidine labelled cells has
      shown that both the bi- and mononucleated cells proceed through the mitotic cycle
      and enter mitosis simultaneously. The nuclei of 2nX2 cells enter prophase
      simultaneously but fuse during metaphase, so that the subsequent division results
      in the formation of mononucleated tetraploid cells.

PMID- 1026879
TI  - [Quantitative evaluation of periodicity of cell movement in the process of
      aggregation].
AB  - A method of quantitative estimation of quasiperiodic cell movements is considered
      which allows to approximate the process under study by the sum of trigonometric
      functions. The possibilities of the method are deomonstrated in the analysis of
      cell and aggregate movement during the development of a sponge Ephydatia
      fluviatilis from dissociated cells, taken as an example. The spectral composition
      of the movement of cell aggregates was found to change with time; the high
      frequencies disappear gradualy and the lower ones appear.

PMID- 1026880
TI  - [Temperature sensitivity of genes controlling chromosome elimination in
      Drosophila hybrids].
AB  - The thermosensitivity and thermosensitive period of the genes controlling the
      elimination of the 6th chromosome of D. littoralis in the hybrids  male D.
      virillis X female D. littoralis were studied. The appearance of flies with the
      mutation glossy (mosaics and haplo-6-flies) served as a criterion of chromosome
      elimination. The genes under study were shown to be cold-sensitive, monophasic.
      The thermosensitive period lasts 2.5 hrs after egg laying--from the 1st cleavage
      division till the beginning of migration of the nuclei in the egg cortex. The
      appearance of almost 100% of haplo-6-flies at at 17 degrees is accounted for by
      the synchronous elimination of the 6th chromosome of D. littoralis during the
      first 3 cleavage divisions. The appearance of mosaics at 25 degrees is accounted
      for by the asynchronous chromosome elimination.

PMID- 1026881
TI  - [Protein binding glucocorticoid hormones (transcortin) during peri-and postnatal
      ontogenesis and pregnancy in rats].
AB  - The constants of association and the energy of interaction between transcortin
      and cortisol, the binding ability and other characteristics of transcortin have
      been studied in the embryos, sexually immature and mature young and old females,
      females on the 14th and 21st days of pregnancy, immature and mature males. The
      constant of association in all the groups amounted to ca. 10(8) and the energy of
      interaction ca. 10 Cal/mole. The embryos and immature rats of both sexes are
      characterized by relatively low levels of the binding ability of transcortin.
      During the sexual maturation, the level of transcortin increased--insignificantly
      in males and markedly in females. The level of transcortin in the latter remained
      almost invariable during pregnancy and senescence. By the electrophoretic and
      sedimentation properties transcortin was the same in different groups. The high
      level of transcortin during pregnancy corresponded to the high level of hormones
      bound by transcortin, the level of these hormones in the embryos being much lower
      than in the mother.

PMID- 1026882
TI  - [Morphologic and radioautographic study of reactivation of peritoneal exudate
      cell nuclei in heterokarya].
AB  - The heterokaryons of undifferentiated mouse fibroblasts (L and 3T3-4E/TK-) and
      various cell elements of the rat peritoneal exudate were obtained under the
      treatment with inactivated Sendai virus. The reactivation of RNA and DNA
      synthesis in the nuclei of highly differentiated periotoneal exudate cells and
      the synthesis of thymidine kinase controlled by the nuclei of peritoneal exudate
      cells were shown to occur in the heterokaryons. During the process of
      reactivation, the ring-like nuclei of polymorphonuclear leucocytes acquired the
      form characteristic of the reactivated nuclei of mononuclears. The morphological
      changes of heparin-containing granules in the cytoplasm of the heterokaryons of
      mast cells and undifferentiated fibroblasts suggest the degeneration and
      breakdown of granules.

PMID- 1026883
TI  - [Study of the metanephros of fetuses, newborn and 2-month-old mice developing
      under conditions of kidney damage to the females by nephrocytotoxic serum].
AB  - In the metanephros of foetuses beginning from the 14 days of development and in
      the newborn mice from females with injured kidneys, marked defects of proximal
      convoluted tubules and less marked defects of glomeruli were noted what
      corresponded to the character of kidney injury in their mothers. At the same time
      the diameter of glomeruli and convoluted tubules, the height and width of their
      cells increased, but the diameter of their nuclei decreased. These changes are
      accompanied by distrophic changes, mainly in the cells of convoluted tubules, the
      most markedly expressed in the newborn mice. No marked histological changes were
      found in the metanephros of two months old experimental mice.

PMID- 1026884
TI  - [Radioautographic study of melanin synthesis in cells of the pigmented epithelium
      of the retina in adult tritons following surgical removal of the retina].
AB  - The results are given for the autoradiographic study of melanin synthesis in the
      pigment epithelium cells of eye retina in the adult newts by the incorporation of
      3H-dioxyphenylalanine (3H-DOPA). The synthesis of melanin began 4--8 days after
      the operation in the peripheral parts of the eye and but it was not observed in
      the central region of the eye fundus even 25 days alter the operation. A
      suggestion is put forward to the effect of the existence of different mechanisms
      for the initiation of melanin synthesis in these subpopulations of pigment
      epithelium.

PMID- 1026885
TI  - [Dynamics of changes in liver tissue antigens during postnatal rat ontogenesis].

PMID- 1026886
TI  - [Formation of the respiratory enzyme apparatus in growing cells. IV. Composition
      of mitochondrial proteins synthesized in developing and germinating corn seeds].
AB  - The mitochondriogenesis in the developing maize embryo involves the accumulation
      of organelles with the relatively reduced matrix antigen content and relatively
      abundant several detergent-soluble membrane components, as compared with the
      mitochondria from differentiated root cells. Several new antigens are
      incorporated into the mitochondria of embryonic axes and scutella of imbibing
      seeds. While the qualitative protein patterns are constant, the ratio of
      individual antigens changes during the subsequent differentiation of root and
      scutellum cells. At the same time similar spectra consisting of 18--20 groups of
      mitochondrial polypeptides with the molecular weight from less than 12,000 to
      115,000 are synthesized but the ratio of individual polypeptide groups changes
      differentially.

PMID- 1026887
TI  - [Age and changes in the isoenzyme spectrum of rabbit thrombocyte lactate
      dehydrogenase].

PMID- 1026888
TI  - Cord blood values on healthy newborn infant, born at the General Hospital "Dr.
      Hasan Sadikin", Bandung.

PMID- 1026889
TI  - Some rare causes of systemic hypertension in children (case report).

PMID- 1026890
TI  - First week mortality rate in low - birth - weight infants after phenobarbital
      treatment.

PMID- 1026891
TI  - A field survey on ancylostomiasis in school children.

PMID- 1026892
TI  - Gram-negative infections and antibiotic usage in the Department of child health
      Cipto Mangunkusumo General Hospital Jakarta.

PMID- 1026893
TI  - Sensitivity test of salmonella typhosa to chloramphenicol and trimethoprim-
      sulphamethoxazole.

PMID- 1026894
TI  - Dengue haemorrhagic fever in Manado, North Sulawesi.

PMID- 1026895
TI  - The result of Schick test among children in Bandung.

PMID- 1026896
TI  - Cardiac complication due to diphtheria in the Dr. Hasan Sadikin General Hospital,
      Banding.

PMID- 1026897
TI  - Bladder puncture in newborns--a bacteriological study.

PMID- 1026898
TI  - Physiotherapy in the treatment of asthmatic children in Bandung.

PMID- 1026899
TI  - Is illness behavior related to chronicity in patients with intractable pain?
AB  - One hundred patients, referred for the management of intractable pain, completed
      a 52-item Illness Behaviour Questionnaire (IBQ). Responses were scored on 7
      scales: general hypochondriasis, disease conviction, psychological versus somatic
      perception of illness, affective inhibition, affective disturbance, denial and
      irritability. IBQ scale profiles were used to study the relationship between
      chronicity of pain and pattern of illness behaviour reported. Except in the case
      of one scale, no significant correlation emerged. This overall lack of
      association between chronicity and illness behaviour remained even when the
      patient sample was restricted to those 20 patients having substantial organic
      pathology associated with their pain. These findings suggest that degree of
      chronicity is unlikely to play a major role in determining the illness behaviour
      manifested by patients with intractable pain.

PMID- 1026900
TI  - Graphic representation of pain.

PMID- 1026901
TI  - Diverse sensory functions with an almost totally divided spinal cord. A case of
      spinal cord transection with preservation of part of one anterolateral quadrant.

PMID- 1026902
TI  - Electrical stimulation of teeth.
AB  - The technical problems of stimulating intact teeth in clinical diagnosis and in
      pain research are discussed. Bipolar stimulation has no advantage over monopolar
      stimulation for most applications. A 100 V constant current stimulator is
      suitable for monopolar stimulation of healthy teeth with a large electrode at
      about threshold intensity, but, for monopolar stimulation up to 150 micronA and
      for bipolar stimulation, very much higher voltages are required and no suitable
      instrument is available. Circuits are given for isolated 100 V and 1kV constant
      current stimulators.

PMID- 1026903
TI  - Detection and decision factors in pain perception in young and elderly men.
AB  - The effect of age on ability to discriminate between levels of electrical
      stimulation of tooth pulp and willingness to report shocks as painful was
      evaluated using the Sensory Decision Theory. While threshold did not increase
      with age for tooth pulp stimulation as is often observed for thermal pain
      thresholds, a significant age deficit in ability to discriminate between
      suprathreshold shocks was observed. Significant changes with age in willingness
      to report the electrical shocks as painful were also observed. These results
      indicate that changes with age in pain perception are complex, involving not only
      possible discrimination deficits but also changes in bias for and against
      labeling noxious events as painful. These findings stress the need for within
      individual comparisons of laboratory techniques for evoking acute pain
      experiences where variables such as age are under consideration.

PMID- 1026904
TI  - Release of platelet 5-hydroxytryptamine by plasma taken from patients during and
      between migraine attacks.
AB  - Experiments were carried out in order to further delineate the pathophysiology of
      the fall of plasma 5-hydroxytryptamine (5-HT) during a migraine attack. Platelets
      from normal subjects were incubated with 14C-labelled 5-HT, and the release of 5
      HT was measured following exposure of these platelets to plasma taken from
      migraine patients during an attack or at headache-free intervals. Plasma taken
      during attacks released significantly more 5-HT. It is concluded that factor(s)
      exist in the serum during migraine attacks, which can cause 5-HT release from
      normal platelets. The identification of this factor may be important.

PMID- 1026905
TI  - The language of pain: intensity.
AB  - Thirty-nine adjectives which may be used to describe a pain experience were rated
      on an "intensity" continuum by 93 subjects, and in a second study by an
      additional 90 subjects. In each study these ratings were intercorrelated and
      factor-analyzed. The first 6 factors extracted were rotated to a simple structure
      criterion. The first factor was identified as an "intensity" factor. Examination
      of the adjectives indicated that intensity relates to "affective-evaluative"
      adjectives rather than "sensory" ones. The implications of these findings for the
      language a patient may use to communicate the intensity of a pain are discussed.

PMID- 1026906
TI  - [Characteristics of distribution of fleas from small mammals and birds in the
      southern taiga of Priirtysh'ie].
AB  - The analysis of the landscape distribution of fleas from small mammals and birds
      in the southern taiga of Priirtishje is given. According to their abundance and
      faunistic composition the population of fleas from small mammals can be arranged
      into four groups: fleas of forest floodland landscape, those of forest-meadow
      floodland landscape, fleas of settlements and bogs.

PMID- 1026907
TI  - [Mass tracing of Aedes vexans vexans by means of radioactive phosphorus for the
      study of their flight range from the breeding sites].
AB  - In the valley of the Upper Yenisei IV instar larvae of A. vexans vexans were
      traced with 32P and then 1.86 mln imagos were released. Among 442 857 mosquitoes
      caught after hatching 243 were traced. Most of the traced individuals did not yet
      start looking for prey and were caught during the first five days near the
      hatching site. 14 radioactive females were caught within 4.5 km distance from the
      hatching site in the following weeks.

PMID- 1026908
TI  - [Biological properties of promastigotes of Leishmania having undergone
      lyophilization].
AB  - Materials are presented of a comparative study of morphological and cultural
      properties and virulence of liophylized cultures of Leishmania tropica major
      after their rehydration or after a long passage on the NNN medium. Results of
      investigations of two initial strains and three substrains obtained after the
      recovery of liophylized cultures have shown that liophylization does not reduce
      essentially the initial strain virulence. The strains undergone liophylization
      and passed repeatedly on the NNN medium have a tendency to a quicker virulence
      reduction rate as compared to initial ones. The culture of promastigotes
      recultivated after liophylization does not differ from the initial one in the
      ranges of 1-7 passages in its morphology, mobility and ability to grow on the NNN
      medium.

PMID- 1026909
TI  - [Certain principles of the secondary simplication of the life cycles of
      helminths].
AB  - On the basis of the analysis of regularities accompanying the secondary
      simplification of the life cycles of helminths on account of the reduction in the
      number of the animals-hosts 8 rules have been formulated. They are based on the
      following important regularities. 1. At the secondary simplification of the life
      cycles of helminths never fall out the first intermediate host in Trematoda and
      the definitive host in Nematoda. This phenomenon is suggested to be called "the
      host stability in the life cycle". 2. Mostly often from the life cycles fall
      secondarily out those hosts which join in the life cycle at its first
      complication later. 3. The phase of the helminth having transformed into a
      parasitic form at the first complication of its life cycle remains the same at
      the secondary simplification of this cycle.

PMID- 1026910
TI  - [Effect of procercoids of Triaenophorus nodulosus on the biology of their 1st
      imtermediate hosts Cyclops strenuus].
AB  - The effect of procercoids of T. nodulosus on the periods of metamorphosis,
      fecundity, survival and the capacity to infect C. strenuus at all copepodid
      stages (I-V) was studied experimentally. It has been first shown that early
      copepodid stages (I-III) can be easily infected and serve as first intermediate
      hosts of T. nodulosus. Under the effect of the parasite the metamorphosis periods
      of the I and 2-nd copepodid stages increase considerably even at the low
      infection intensity while at the IV and V copepodid stages--only at the high
      infection intensity. If the infection takes place at the IV copepodid stage the
      female fecundity decreases even at a high infection intensity. The life span of
      infected and noninfected cyclops coincides. At early developmental stages the
      relations in the system "T. nodulosus-C. strenuus" manifest themselves in
      different ways and result in the breach of the important biological function of
      the host.

PMID- 1026911
TI  - [Osmotic tolerance and adaptation to hypotonic medium of Echinorhynchus gadi
      (Acanthocephala, Echinorhynchidae)].
AB  - Minimum of the osmotic pressure in the intestine of the cod corresponds to the
      osmotic pressure of sea water of 10%. The sorbtion level of neutral red by intact
      E. gadi remained practically unchanged after their maintenance in sea water of 8
      10 to 30% during 24 hours (ecological optimum). Specimens of E. gadi transferred
      from 10 to 4% displayed compensatory recovery of the normal sorbtion level of the
      dye by the 5th-6th day of the experiment. The ability of Acanthocephala
      possessing extreme eutelia to a physiological adaptation is indicative of its not
      obligatory participation of mitotic processes in the acclimation.

PMID- 1026912
TI  - [Genetic-physiological compatibility and karyotypes of stem nematode].
AB  - The paper presents literary and the authors own data. The potato stem eelworm
      Ditylenchus destructor has a set of chromosomes 2n=44-48 and does not cross with
      the close species D. dipsaci from onion, garlic, parsley and parsnip. Most stem
      eelworms of the collective species D. dipsaci have n=12 and cross with each other
      producing fertile progeny. Some forms of stem eelworms, e.g. those of broad
      beans, plantain, dandelion and falcaria are polyploid. Intraspecies and
      intrapopulation polymorphism according to the number of chromosomes was recorded.
      Some races do not cross, some cross but unilaterally, some races produce sterile,
      non-viable or little viable hybrids. The species D. dipsaci should be regarded
      not only as a complex of species but as a group of forms at different stages of
      intraspecies differentiation.

PMID- 1026913
TI  - [Tarsal gland of ixodid ticks (Ixodidae)].
AB  - In the tarsi of all legs of Ixodes persulcatus, Dermacentor daghestanicus,
      Rhipicephalus turanicus and Hyalomma asiaticum the multicellular gland was
      observed. The gland is formed by a single layer of glandular cells that form a
      central cavity where two ciliary structures in a cuticular (scolopoid) sheath are
      situated. A possible function of the gland is discussed in the article.

PMID- 1026914
TI  - [Carassotrema koreanum Park, 1938 (Trematoda, Waretrematidae) and a new species
      of this genus from fresh water fishes of North Vietnam].
AB  - In freshwater fishes of North Viet-Nam were found representatives of the family
      Waretrematidae, Carassotrema koreanum and a new species of this genus, C.
      ginezinskajae sp. n., close to C. koreanum and differing from it in the structure
      and extent of yolk glands, relatively larger sizes of the pharynx and suckers,
      the location of spines and body shape. The described species differs from the
      other species of this genus, C. mugilicola, in the shape and location of testis,
      structure and location of yolk glands, intestine extent, size of suckers and
      pharynx, presence of cirrus, location of spines on the body and in other
      characters. Asymphylodora pavlovskajae Ha Ky, 1969 and Asymphylodora
      ginezinskajae Ha Ky, 1969 are reduced to synonyms of Carassotrema koreanum and C.
      ginezinskajae sp. n.

PMID- 1026915
TI  - [New species of spiral nematode from the mountain tundra of Kamchatka].
AB  - A new species of nematodes, Rotylenchus alpinus sp. n., is described. The species
      was found in the rhizosphere of Vaccinum uliginosum and Arctous alpina from the
      mountain tundra of Kamchatka. It differs from the close species R. orientalis in
      having a higher place of entering of the oesophagal dorsal gland duct, well
      developed hind ovary and in having males. From R. goodeyi the species differs by
      a lower place of entering of the dorsal gland duct, smaller sizes of the body and
      gubernaculum.

PMID- 1026916
TI  - Metastases from single as compared to repeated tumour cell doses.
AB  - Tumour formation from single or repeated small i.v. tumour cell doses was studied
      in a syngeneic tumour-host system. Only marginal differences were observed
      between different dose schedules, once the critical cell dose level was
      surpassed.

PMID- 1026917
TI  - Experimental allergic sialoadenitis. IX. The regional lymph nodes after antigenic
      challenges of the parotid glands in rats.
AB  - The regional lymph nodes of the parotid gland of rats were examined
      histologically. The nodes were removed from untreated animals or rats given
      instillations of BSA or saline into the parotid duct. Anti-BSA antibodies were
      assessed in the saliva and serum. Patterns of reactivity of the lymph nodes did
      not correlate with the presence or absence of salivary and serum antibodies. The
      occurrence of antibodies in the saliva appears to reflect the activity of
      immunocytes residing in the parotid gland. The morphological features of the
      lymph nodes correspond to the overall immunological experience.

PMID- 1026918
TI  - Aortic endothelial and sub-endothelial lesions in early stages of experimental
      atherogenesis and in scurvy.
AB  - The endothelial and sub-endothelial lesions during early stages of experimental
      atherogenesis and scurvy have been studied by means of scanning EM and
      transmission EM, making use also of the Con-A reaction. The surface coat
      modifications were accompanied by formation of vacuoles in the endothelial cells
      and by sub-endothelial 'oedema', not only in rabbits fed a hypercholesterolic
      diet but also in scorbutic guinea pigs. The endothelial lesions were sometimes
      found even before clear modifications of the Con-A surface reactive layer were
      apparent.

PMID- 1026919
TI  - Plasma cell alterations in ulcerative colitis. An electron microscopic study.
AB  - Colon biopsies from 37 young patients with active ulcerative colitis (UC) were
      investigated by electron microscopy with special regard to the inflammatory
      infiltrate of the lamina propria mucosae, which is characterized by lymphocytes,
      macrophages and plasma cells. There are close topographical relations between
      plasma cells and other inflammatory cells. In particular, different forms of
      plasma cells occur, which mainly differ in shape and contents of their rough
      endoplasmic reticulum (RER). The different degrees of development and dilatation
      of the RER express different functional states. The frequent occurrence of
      Russell bodies, Mott cells and necrobiotic plasma cells is explained as a--at
      least partial--pathologic alteration of plasma cells in UC. In context with
      recently published immunohistochemical findings these observations permit the
      assumption of an imbalance of the local Ig-system in UC.

PMID- 1026920
TI  - Note on the ultrastructure of the Guerin T-8 transplantable tumour.
AB  - The ultrastructure of the Guerin tumour T-8 is described. Although this
      transplantable tumour has its ancestry in an uterine adenocarcinoma, there is no
      more evidence of gland formation. Desmosomes, or any other form of cell
      attachment organelle, were totally absent. The tumour has now a very anaplastic
      sarcomatous appearance.

PMID- 1026921
TI  - [Unknown Salmonella strains: epidemilogical profile and physiognomy of their
      resistance to antibiotics].

PMID- 1026922
TI  - [Dermatophytes isolated from man, dog and cat in the city of Rome].

PMID- 1026923
TI  - [Dermatophytes isolated from man, dog and cat in the city of Bologna].

PMID- 1026924
TI  - [Human hydatidosis in Abruzzo--hypothesis on localization].

PMID- 1026925
TI  - [Study on the antibacterial activity of the combination cefazolin-dicloxacillin].

PMID- 1026926
TI  - [Exposure to noise in the industry and its hygienic and guiding aspects].

PMID- 1026927
TI  - [Contribution of veterinary medicine to public health].

PMID- 1026928
TI  - [Integral medicine. Apropos of social security].

PMID- 1026929
TI  - [Social ecology].

PMID- 1026930
TI  - [Iatrogenic disease and ecology (II)].

PMID- 1026931
TI  - [The importance of Scotochromogenous mycobacteria in the urine].
AB  - In order to find the significance of the presence of Scotochromogenous
      Mycobacteria in the urine, 155 cases with this finding and without other
      Mycobacteria were analyzed. Most had urinary symptoms (91.6%), abnormal urine
      analysis (62.5%), negative urine culture (71.7%), and changes in intravenous
      pyelograms (89.5%). Clinical and laboratory improvement was noticed in 70% of
      those who received antituberculous drugs and in 30% of those who did not receive
      them (P less than 0.01). All of the foregoing characteristics were present in
      each 23 patients with repeated isolations of Scotochromogens in the urine, and
      could be cases of urinary-tract disease due to Scotochromogens. In other patients
      this Mycobacteria could coexist with M. tuberculosis, or be a contaminant,
      although Scotochromogens were not found in the urine of 100 control subjects, a
      significant difference to these patients (P less than 0.0001).

PMID- 1026932
TI  - [Surgical treatment of obesity. Comparative study of the different technics of
      intestinal resection].

PMID- 1026933
TI  - [Diagnosis of amebiasis].

PMID- 1026934
TI  - [Leukemia of plasma cells].
AB  - A case of plasma cell leukemia is reported, together with a review of the
      literature, including a summary of the signs, symptoms and laboratory findings
      usually present. The relationship of this leukemic state to ordinary multiple
      myeloma is discussed.

PMID- 1026935
TI  - [Certain aspects of transformation of 21-acetate of the Reichstein substance "S"
      by the culture of Tieghemella orchidis].
AB  - The transformation of acetate from the Reichstein substance "S" by the culture of
      Tieghemella orchidis was studied upon a single and fractional addition of the
      substrate. The effect of streptomycin sulphate, Tween-80, ethanol (steroid
      solvent) and steroid solution on the respiratory activity of the culture was
      investigated upon a single and fractional addition of the steroid. During
      transformation the respiratory activity of the culture decreased--by the end of
      the process (18-20 hours) it fell 2-2.5-fold upon a single addition of the
      steroid (1 g/l) and by 20% upon a fractional addition of the steroid (2 g/l). In
      the latter case the respiratory activity dropped step-by-step if the
      concentration of the steroid was 1.4-1.6 g/l; simultaneously the transformation
      activity declined.

PMID- 1026936
TI  - [Effect of porphyrins and their derivatives on biosynthesis of vitamin B 12 and
      the development of Propionibacterium shermanii].
AB  - The effect of uroporphyrin, coproporphyrin and their cobalt-containing
      derivatives on the biosynthesis of vitamin B12 and development of
      propionibacterium shermanii was studied. The compounds under study stimulated the
      vitamin synthesis by growing cultures and resting suspensions of these bacteria.
      Cobalt porphyrins as the sole source of cobalt were used in the vitamin B12
      biosynthesis. An addition of cobalt porphyrins to the growing culture of
      propionic bacteria increased in accumulation of their biomass. Possible
      mechanisms of porphyrin involvement in the biosynthesis of vitamin B12 and the
      specific role of cobalt porphyrins in the bacterial activity are discussed.

PMID- 1026937
TI  - [Relationship between exoprotease activity, spore and crystal formation and
      virulence of bacteria of the group Bacillus thuringiensis].
AB  - Experiments were carried out to investigate the activity, spore and crystal
      formation and virulence of Bacillus thuringiensis. Bacteria of this group showed
      different exoprotease activity. Strains of one serotype differed in the level and
      time of occurrence of peak enzyme activity. Exoprotease activity of the bacteria
      cannot be indicative of their toxicity because it did not correlate with their
      virulence. Exoprotease activity can be used to characterize bacteria during their
      classification  and to determine finer differences between strains within one
      serotype.

PMID- 1026938
TI  - [Mass-spectrometric study of the mechanism of microbial oxidation of 3
      pyridinaldehyde].
AB  - In order to clarify mechanisms of nicotinic acid synthesis during microbial
      transformation of 3-methylpyridine, microbial and spontaneous air oxygen
      oxidation of 3-pyridinaldehyde to nicotinic acid in the H218O environment was
      studied. It was shown that during spontaneous oxidation the label was
      incorporated into one atom of oxygen in the carboxylic group of nicotinic acid.
      During the microbial oxidation the label was equally incorporated into both atoms
      of oxygen in the carboxylic group of nicotinic acid. It is concluded that the
      mechanisms of spontaneous and microbial oxidation of 3-pyridinaldehyde are
      different. It is suggested that the possible precursor of nicotinic acid during
      microbial oxidation may be hydroxy-3-pyridinaldehyde.

PMID- 1026939
TI  - [Thermogenesis of mesophilic, thermotolerant and thermophilic strains of
      microorganisms--producers of fungal cell wall--destroying enzymes].
AB  - Investigations were carried out to clarify the relationship between thermogenesis
      and production of yeast wall lyzing enzymes by the mesophilic strain of Bacillus
      subtilis, thermotolerant strain of Actinomyces sp. II and thermophilic strain of
      Actinomyces sp. 10. The enzymic lyzing activity was measured in the culture
      liquid filtrate of those microorganisms. The thermophilic strain of Actinomyces
      sp. 10 showed the highest enzymic activity. The thermogenetic curves of the
      cultures had several inflections. The mesophilic culture of Bacillus subtilis
      whose enzymic lyzing activity was the lowest displayed the highest heat release.

PMID- 1026940
TI  - [New strain of methylotrophic bacteria Pseudomonas oleovorans--a polysaccharide
      producer].
AB  - A new strain of facultative-methylotrophic bacteria was isolated and identified
      as Pseudomonas oleovorans. The culture grew on the methanol-containing medium (up
      to 6%). In addition to methanol, bacterial growth was provided by different
      organic acids, multicarbon alcohols and carbohydrates. During growth bacteria
      synthesized extracellular polysaccharide (up to 400 mg/ml). The compound included
      glucose, galactose and xylose.

PMID- 1026941
TI  - [Purification of pancreatic kallikrein by the method of affinity chromatography].
AB  - Pancreatic Kallikrein was purified by affinity chromatography on BPTI-Sepharose.
      Immobilized BPTI was prepared via three stages: a) formation of the BPTI-
      acetylated trypsin complex; b) coupling of the resultant complex with CNBr
      activated Sepharose; c) dissociation of the bound complex at pH 2.0 to yield
      immobilized BPTI and acetylated trypsin. The final product contained 59 X 10(-3)
      micronmoles insolubilized BPTI/ml Sepharose. Trypsin occurring in commercial
      Kallikrein preparations was separated by the batch procedure with ovomucoid
      Sepharose. This method allows 100-fold purification of commercial Kallikrein.

PMID- 1026942
TI  - [Isolation of iodine-protein components from sea algae].
AB  - The isolation of iodorganic compounds from the Black Sea red alga Phyllophora
      nervosa and its by-products obtained from industrial treatment was investigated.
      The algal biomass was pressed to remove alkali, subjected to 5-10 min treatment
      with 11-12% sodium hydrate, and drying at 125-130 degrees C and washed to yield
      95% iodine and over 80% proteins. Iodine was found to be bound with protein of
      Phyllophora. Properties of the isolated iodine-peptide fractions were studied.

PMID- 1026943
TI  - [Modification of the spectrophotometric method of determination of pyridoxal-5'
      phosphate and pyridoxal in enzymatic preparations].
AB  - In quantitative measurements of pyridoxal-5'-phosphate and pyridoxal in enzymes
      routinely used phenylhydrasine was substituted for 4-nitrophenylhydrasine. This
      increased the sensitivity of the method by 70%. The modified procedure had
      another advantage: it allowed measurements of the optic density of resulting 4
      nitrophenylhydrasones at 430 nm for acid solutions and at 550 nm for alkaline
      solutions.

PMID- 1026945
TI  - Medical-scientific dilemmas of our third century.

PMID- 1026944
TI  - Thrombo-embolism.

PMID- 1026946
TI  - Radiation to the head, neck and upper thorax of the young, and thyroid neoplasia.

PMID- 1026947
TI  - Operations for patients with nodular irradiated thyroids.

PMID- 1026948
TI  - Radiation and thyroid cancer.

PMID- 1026949
TI  - Regulation of pancreatic exocrine secretion.

PMID- 1026950
TI  - Action of ouabain, oligomycin, and glucagon on cultured heart cells treated with
      adriamycin.

PMID- 1026951
TI  - Observations on the "in vitro" oxidative N-demethylation of 4-(3, 3-dimethyl-1
      triazeno)-imidazole-5-carboxamide (DIC, NSC 45388).

PMID- 1026952
TI  - Relationship between antiinflamatory and antiproteolytic properties of
      substituted oxothiazolylacetic acids.

PMID- 1026953
TI  - Receptor involvement in monoamine control of thermoregulatory mechanisms in adult
      fowls.

PMID- 1026954
TI  - Comparison of cumulative and individual dose-response curves on the rat uterus of
      neurohypophyseal peptides.

PMID- 1026955
TI  - Clinical significance of microsomal enzyme induction.

PMID- 1026956
TI  - Some pharmacological actions of 3-methyl-4-nitro-furoxan.

PMID- 1026957
TI  - Sarcoma 180 weight, DNA, and protein increase, depending on ARA-C schedule.

PMID- 1026958
TI  - Influence of repeated injections of estradiol during late pregnancy upon enzymes
      of monoamine metabolism and biosynthesis in the rat.

PMID- 1026959
TI  - Influence of thyroidectomy and compensatory treatment with L-thyroxine upon
      tissue glycogen stores during last part of pregnancy in the rat.

PMID- 1026960
TI  - Effect of phosvitin on smooth muscle 'in vitro'.

PMID- 1026961
TI  - Steroid hormones, anti-inflammatory steroids and prostaglandins.

PMID- 1026962
TI  - Effect of glutathione on the liver and brain metabolism of anoxic rats.

PMID- 1026963
TI  - Macromolecular drugs I: long-lasting antilipolytic activity of nicotinic acid
      bound to a polymer.

PMID- 1026964
TI  - A simple raio-enzymatic determination of choline and acetylcholine
      concentrations.

PMID- 1026965
TI  - Pharmacokinetics of Flavoxate in man.

PMID- 1026966
TI  - Some new dithiolanes as radioprotective agents.

PMID- 1026967
TI  - Inhibition of gastric acid secretion by somatostatin and analogs in the rat.

PMID- 1026968
TI  - Further studies on the differential blockade of pressor responses in the rat.

PMID- 1026969
TI  - Inhibition of monoamine oxidase activity by phenacetin and salicylamide.

PMID- 1026970
TI  - Effect of intrahypothalamic injection of methylic parathion and metasystox on
      food and water intake of normal and fasted rats.

PMID- 1026971
TI  - Plasma levels of digoxin in patients with atrial fibrillation and indications to
      the association with beta blockers.

PMID- 1026972
TI  - Inhibiting effect of feprazone on "in vitro" human platelet aggregation.

PMID- 1026973
TI  - Variations of plasma renin activity and aldosterone levels in the rat after
      administration of saline, chrystalloid and colloid solutions (1).

PMID- 1026974
TI  - Effect of bendazac and phenylbutazone on polymerization of bovine serum albumin.

PMID- 1026975
TI  - Effect of clofibrate on biogenic amine level and turnover.

PMID- 1026976
TI  - Antagonistic effect of lithium chloride on l-dopa-induced locomotor activity in
      rats.

PMID- 1026977
TI  - Effect of brain cortex phospholipids on catechol-amine content of mouse brain.

PMID- 1026978
TI  - Antagonism of morphine-induced miosis by naloxone and amphetamine in rabbits.

PMID- 1026979
TI  - Stimulation bound ingestive behavior: a view from the tail.

PMID- 1026980
TI  - Fixed-ratio level pressing by VMH rats: work vs accessibility of sucrose reward.

PMID- 1026981
TI  - Dissociation of behavioral inhibition within the fornix system.

PMID- 1026982
TI  - Effect of medial septal lesions on conditioned taste aversion in the rat.

PMID- 1026983
TI  - [Significance of behabioral parameters in mice in open field (author's transl)].

PMID- 1026984
TI  - Intracerebral implantation of progesterone: re-examination of the brain sites
      responsible for facilitation of sexual receptivity in estrogen-primed
      ovariectomized rats.

PMID- 1026985
TI  - Role of gastric acid in restraint-induced ulceration in the rat.

PMID- 1026986
TI  - Stimulation in infancy: unique effects of handling.

PMID- 1026987
TI  - Involvement of vagal activity in the unconditioned heart-rate responses of
      restrained rats.

PMID- 1026988
TI  - Copulatory behavior in male rats with lesions in the bed nucleus of the stria
      terminalis.

PMID- 1026989
TI  - Sexual behavior of the naive male mouse as affected by the presence of a male and
      a female performing mating behavior.

PMID- 1026990
TI  - Dependence of polyethylene glycol-induced dipsogenesis on intravascular fluid
      volume depletion.

PMID- 1026991
TI  - Apomorphine-induced restoration of drinking to thirst challenges in 6
      hydroxydopamine-treated rats.

PMID- 1026992
TI  - Multidimensional scaling of musks.

PMID- 1026993
TI  - Genetic analysis of schedule induced polydipsia.

PMID- 1026994
TI  - Adjunctive behavior and smoking induced by a maze solving schedule in humans.

PMID- 1026995
TI  - Locus coeruleus lesions and learning in the rat.

PMID- 1026996
TI  - Use of oral antibiotics in studies of ingestive behavior in rats.

PMID- 1026997
TI  - Aftereffects of rewarding lateral hypothalamic brain stimulation and feeding
      behavior.

PMID- 1026998
TI  - The relationship of home cage feeding behavior to acquisition of schedule-induced
      polydipsia in the rat.

PMID- 1026999
TI  - An avian experimental environment for the study of social behavior.

PMID- 1027000
TI  - [Early childhood psychoses and their treatment].

PMID- 1027001
TI  - [Epileptic children and adolescents. A clinical and psychopathological approach].

PMID- 1027002
TI  - [Observation classes].

PMID- 1027003
TI  - [The therapeutic community--a changed concept of roles (author's transl)].

PMID- 1027004
TI  - [The mentally ill and their psychiatric care--opinions and experience of the
      inhabitants of Duesseldorf, Essen and Cologne (author's transl)].

PMID- 1027005
TI  - [Role concept of patients and team in an admission and rehabilitation station.
      (Address at the 16. International Educational Congress for Nurses, Caretakers and
      Social Workers, Heidelberg University, October 7, 1975)].

PMID- 1027006
TI  - [Psychiatric in-patients' opinions and attitudes to industrial work-therapy and
      to occupational therapy (author's transl)].

PMID- 1027007
TI  - [Homes for the mentally handicapped: alternative methods of treatment as shown on
      the example of the homes of the Association for the Care of Mentally Handicapped
      in Hannover (author's transl)].

PMID- 1027008
TI  - [Psychiatry in Senegal].

PMID- 1027009
TI  - [Social learning for mentally ill through role playing in a group].

PMID- 1027010
TI  - [Report of experiences in developing a "social-centre" (author's transl)].

PMID- 1027011
TI  - [The significance of central therapeutic social facilities for the modern
      stationary care of the mentally ill (author's transl)].

PMID- 1027012
TI  - [The schizophrenic patients in a large mental hospital from the view point of the
      psychiatric nursing personel. A contribution toward the differentiation of the
      patient population (author's transl)].

PMID- 1027013
TI  - [Reading as therapy at a mental hospital--an experiment (author's transl)].

PMID- 1027014
TI  - [Method and form of therapeutic groups in stationary psychiatry (author's
      transl)].

PMID- 1027015
TI  - [Civil rights of psychiatric patients in the United States. Minimal medical and
      constitutional standards for adequate treatment].

PMID- 1027016
TI  - [Model for a sociopsychiatric out-patient clinic? (author's transl)].
AB  - In the psychiatric social services of the Public Health Departments in Berlin
      (Charlottenburg, Spandau, Kreuzberg), data concerning the clients, the work of
      the coworkers and the quality of client care were collected. More than 80% of the
      clients of the psychiatric social service suffer from severe psychiatric
      disturbances: alcoholism, psychiatric geriatric illness and schizophrenia. This
      diagnosis range  differs significantly from that of the physicians in a private
      practice. Competition, therefore, does not exist between the psychiatric social
      services and the psychiatrists in a private practice. --The coworkers of the
      social istuation (housing, profession, salary and social contacts) to be poor for
      every second (to third) client and unfavorable for the course of the disease.
      Psychiatric social care in the areas of medicine, nursing and welfare as well as
      the coordination of the care was evaluated as unsatisfactory for every second (to
      third) client. --Dor social workers and physicians, the percentage of direct
      patient-oriented activity was about 45%, the percentage of indirect patient
      oriented activity was about 55%, about 40% of the work-time was used for
      administration. An improvement in the organization could free more work-time for
      meaningful activity. --The psychiatric social services fulfill an important
      function for out-patient care, particularly for the severly mentally disturbed.
      The existing gaps in client care cannot begin to be closed by just expanding the
      psychiatric social services in terms of personnel in the Public Health
      Department. Extensive structural changes must also be made in regard to
      psychiatric care.

PMID- 1027017
TI  - [Teamwork in the juvenile social work? (author's transl)].

PMID- 1027018
TI  - [The YY-syndrome--a forensic problem? (author's transl)].

PMID- 1027019
TI  - [Comparison between the traditional daily visit (of the therapist) and the daily
      groupmeeting with cronic psychiatric in patients (author's transl)].

PMID- 1027020
TI  - [Thoughts on the slogan "Everything normal as possible". 2. Report on the social
      center and sports center of the Westphalian county hospital in Dortmund].

PMID- 1027021
TI  - [DNA degradation and repair in radio-sensitive tissues of irradiated rats].

PMID- 1027022
TI  - [Effect of ionizing radiation on enzyme binding by subcellular structures. 1.
      Binding and solubilization of lactate dehydrogenase].

PMID- 1027023
TI  - [Radiation shifts in the cerebral enzyme activity of rats following
      adrenoblockader administration].

PMID- 1027024
TI  - [Development of chromosome aberrations in fish embryos under the influence of
      chronic irradiation].

PMID- 1027025
TI  - [Morphologic characteristics of radiation damage to the small intestine of mice
      irradiated during different periods of postnatal development].

PMID- 1027026
TI  - [Effect of heparin on repair processes in irradiated organisms].

PMID- 1027027
TI  - [Regeneration of nerve structures following irradiation].

PMID- 1027028
TI  - [Effect of a fractionated radiation dose on the kinetics of hematopoietic stem
      cells].

PMID- 1027029
TI  - [Radioprotective effect of an extract of intestinal mucosa].

PMID- 1027030
TI  - [Early destructive changes in the intestinal mucosa of rats and mice irradiated
      with superlethal doses. 1. Interphase death of crypt epithelial cells].

PMID- 1027031
TI  - [State of several parameters of oxygen metabolism in rat tissues during the
      dynamics of radiation injury under high altitude conditions].

PMID- 1027032
TI  - [Distribution and biological activity of californium-252 following intratracheal
      administration].

PMID- 1027033
TI  - [Effect of different concentrations of radioisotopes on the degree of
      incorporation and the viability of potato seeds].

PMID- 1027034
TI  - [Effect of exogenous ATP on de novo biosynthesis of pyrimidine nucleotides in rat
      tissues under conditions of prolonged gamma-irradiation].

PMID- 1027035
TI  - [Inhibition of matrix activity of irradiated DNA in the presence of antibodies to
      DNA].

PMID- 1027036
TI  - [Effect of low-molecular DNA on the genome of somatic cells of healthy and
      irradiated animals].

PMID- 1027037
TI  - [Use of uracil and thymidine for deoxyuridine biosynthesis in irradiated
      organisms].

PMID- 1027038
TI  - [Free-radical states of the tissues of white rats irradiated with x-rays and fast
      neutrons after preliminary adaptation to hypo- and hyperoxia].

PMID- 1027039
TI  - [Effect of caffeine on the cytogenetic effect of irradiating seeds of the
      polyploid series of wheat].

PMID- 1027040
TI  - [Effect of the position and type of the substituent in a series of
      indolylalkylamines on electron-donor properties and radioprotector activity].

PMID- 1027041
TI  - [Patterns in the formation of radioraces in yeasts. 9. Features of race-formation
      in haploid yeasts].

PMID- 1027042
TI  - [Cobalt concentration in rabbit tissues following exposure to x-rays].

PMID- 1027043
TI  - [Detection of economically useful traits in gamma-irradiated lupine plants].

PMID- 1027044
TI  - [Effect of gamma-irradiation and subsequent storage on formation of gibberlin
      like substances during sprouting of spring wheat seeds].

PMID- 1027045
TI  - [Results of presowing gamma-irradiation of wheat and barley seeds in the Ryazen
      area].

PMID- 1027046
TI  - [Comparison of the diagnostic efficacy of various in vitro tests for the study of
      thyroid performance (author's transl)].
AB  - Discriminating analysis was employed in an evaluation of the diagnostic efficacy
      of individual in vitro tests of thyroid performance (T3 resin uptake, T4, FTI,
      ETR) and PB131I determination, and their combinations, when used for the
      differentiation of euthyroid, Basedow hyperthyroid, hyperfunctioning autonomous
      adenoma, and hypothyroid cases. The results are discussed with reference to
      optimization of the data: radiation dose ratio.

PMID- 1027047
TI  - [Sialography and scintigraphy in salivary pathology (author's transl)].
AB  - 58 cases of salivary glands pathology were investigated by means of sialography
      and scintigraphy in order to compare these methods. The usefulness of this
      association is discussed and a number of significant cases are presented.

PMID- 1027048
TI  - [Angioscintigraphy with gammacamera in vascular pathology of the encephalon
      (author's transl)].
AB  - Serial angioscintigraphy with 99mTc-pertecnetate and gamma camera was carried out
      in more than 500 cases of cerebropathies with various but prevalently vascular
      pathogenesis. Pictures are described and discussed with reference to the
      differential diagnosis, and a number of significant cases are reported in detail.

PMID- 1027049
TI  - [67Ga scintiscanning in the diagnosis of lung diseases (author's transl)].
AB  - The results observed with 67Ga scintiscanning in 101 cases of lung disease are
      presented and discussed in relation to the final diagnosis, and hence the
      reliability of the examination.

PMID- 1027050
TI  - [133Xe functional evaluation of the lung in obstructive syndromes (author's
      transl)].
AB  - 124 patients with obstructive broncho-pulmonary syndromes have bzen studied with
      133Xe moving scanning. The method and the results are described; 5 cases are
      reported in detail.

PMID- 1027051
TI  - [Diagnostic possibilities of scintigraphy with radiocholesterol (author's
      transl)].
AB  - Scintigraphy of the suprarenal glands with 131I-iodocholesterol has been
      performed by means of a linear scanner or gamma-camera in 56 subjects. The
      results are presented and discussed and some cases are reported in detail.

PMID- 1027052
TI  - [First attempt at evaluating the overall risk induced in the diagnostic use of
      radionuclides (author's transl)].
AB  - An attempt to evaluate the total radiation risk caused by the diagnostic use of
      radionuclides was made. The estimate was based on the calculation of the
      genetically significant dose the mean dose in the bone marrow and the dose in the
      whole body and in the organs which accumulate the radionuclides. The statistical
      data were furnished by the nuclear medicine service of the Province of Varese.

PMID- 1027053
TI  - [Female sterilization by minilaparotomy in ambulatory patients: a modified
      technic].

PMID- 1027054
TI  - [Labour induction with prostaglandines F 2-alpha (author's transl)].

PMID- 1027055
TI  - Changes in cell age cohort composition of tumors and normal tissues by radiation
      and chemotherapy.
AB  - The cell cycle is now known to be important in normal and tumor tissue and to be
      altered by a variety of states and therapies. The fact that there is considerable
      normal variation in cell ages or age cohorts present in both normal and tumor
      tissues has only recently been widely appreciated. These differ in normal,
      malignant, young and adult tissues. They are also greatly perturbed by radiation
      or chemotherapeutic injury. How to combine multi-modality therapy to optimize
      tumor control using available agents while sparing normal tissues is a problem
      for the future of cancer therapy and radiation oncology.

PMID- 1027056
TI  - Editorial...

PMID- 1027057
TI  - The esophagus in collagen disease. Radiologic findings.
AB  - A prospective cineradiographic and manometric study of pharyngeal and esophageal
      dysfunction was performed in 54 patients with rigidly defined scleroderma,
      polymyositis, systemic lupus erythematosus, and rheumatoid arthritis.
      Cineradiography was inaccurate in pharyngeal dysfunctions specific for
      polymyositis. Manometry was an accurate but insensitive test. Manometry was also
      significantly more accurate than cineradiography in identifying patients with
      smooth muscle dysfunction (scleroderma). Cineradiographic finding of absent
      esophageal peristalsis accurately identified patients with scleroderma but it
      identified only a small percentage (33 percent). Cineradiography finding of
      diminished esophageal peristalsis was found in scleroderma (23 percent),
      polymyositis, (30 percent), and SLE (11 percent) and has been reported in
      rheumatoid arthritis. This finding is a non specific finding suggestive of
      collagen vascular disease rather than specific for scleroderms.

PMID- 1027058
TI  - Contribution of radioactive impurities of 99mTc in the dosage absorbed by the
      patients.

PMID- 1027059
TI  - The decline and early fall of neonatal pulmonary hemorrhage.
AB  - Seven years' experience (1965-1972) with neonatal pulmonary hemorrhage at the
      University of Colorado was reviewed. Pulmonary hemorrhage still occurs frequently
      as a preterminal event in hyaline membrane disease. As an isolated "pure" entity,
      however, pulmonary hemorrhage has shown a marked decline. This phenomenon is
      probably related to advances in neonatal intensive care. The radiographic pattern
      of "pure" pulmonary hemorrhage in the newborn is most commonly a diffuse alveolar
      infiltrate. Since pure hemorrhage is now an uncommon entity, the radiologist can
      reasonably suggest this diagnosis on rare occasions only, in the clinical setting
      of profound hypoxia.

PMID- 1027060
TI  - Complete interruption of the aorta in Noonan's syndrome.
AB  - A patient is presented who lived to age 60 with complete interruption of the
      aorta associated with Noonan's syndrome. On chest x-ray there were calcified
      mediastinal masses and bilateral rib notching. Angiography demonstrated complete
      interruption of the aorta with markedly dilated tortuous intercostal arteries.
      The roentgenographic studies are correlated with the surgical and pathological
      findings. Noonan's syndrome is discussed.

PMID- 1027061
TI  - Neoplastic involvement of terminal digits masquerading clinically as benign
      disease.
AB  - Two patients with primary and four with metastatic distal phalangeal lesions in
      whom a wrong diagnosis of benign disease was initially made are presented with a
      brief review of the literature and a discussion of the clinico-radiographic
      features. Primary phalangeal lesions may be either epidermoid carcinoma or
      malignant melanoma are are often confused with paronychia, while most metastatic
      lesions are due to pulmonary or breast cancer and simulate a felon clinically.
      Primary nail bed lesions are characterized radiographically by external cortical
      erosions; metastatic lesions tend to show a diffuse demineralization and
      extensive destruction of the whole digit.

PMID- 1027062
TI  - Evaluation of intracranial aneurysms by computed tomography.
AB  - Useful information has been gained by review of eight cases of intracranial
      aneurysm demonstrated by computed tomography (CT) and correlation with cerebral
      angiograms. The angiograms demonstrated one or multiple aneurysms, the precise
      location of the aneurysm, and presence of arterial spasm. The CT scan can
      delineate the full size of the aneurysm when the sac has been partially
      obliterated by thrombus, the presence of hematoma, infarction, hydrocephalus, and
      intraventricular and subarachnoid hemorrhage. These associated features are more
      difficult to evaluate by angiography alone.

PMID- 1027063
TI  - Radiographic evaluation of patency of interposition mesocaval shunts.
AB  - The technique of side-to-side mesocaval anastomosis with the interposition of a
      prosthetic graft was described in 1970. We report the result of venographic
      evaluation of patency of this type of shunt in our patients. Demonstration of an
      unoccluded graft; resistance to retrograde injection of dye against the blood
      stream into the superior mesenteric vein; rapid clearing of dye from superior
      mesenteric vein following injection and "lamellar flow defect" in the vena cava
      above the site of anastomosis during vena cavogram, were considered criteria of
      patency of the interposition mesocaval shunt.

PMID- 1027064
TI  - Percutaneous cholangiography with the Chiba University needle: a new, safe, and
      accurate method in the diagnosis of cholestatic syndromes.
AB  - A modified technique of percutaneous transhepatic cholangiography utilizing the
      Chiba University needle is described. This new technique employs injection of dye
      through a thin flexible 22 gauge needle with a short bevel while it is slowly
      withdrawn under a fluoroscopic monitoring. The results of several investigators
      are reviewed and indicate that failure to visualize the biliary radicals with the
      Chiba University needle virtually rules out extrahepatic obstruction. It is
      anticipated that this technique will replace the traditional sheathed needle
      cholangiography as a diagnostic modality in the evaluation of the jaundiced
      patient.

PMID- 1027065
TI  - Radiologic differential diagnosis. Radiologic pattern: solitary cavity.
AB  - The differential diagnosis of a left lower lobe cavity in this young patient with
      a history of productive cough should include hiatal hernia, pulmonary abscess,
      bronchiectatic cyst and bronchopulmonary sequestration. Hiatal hernia should be
      ruled out by barium swallow; acute pulmonary abscess by the lack of a history
      suggestive of a necrotizing pneumonia; bronchiectasis by bronchogram; and
      intralobar bronchopulmonary sequestration should be confirmed by aortography.

PMID- 1027066
TI  - The normal axial relationship of the wrist.
AB  - The normal axial relationship of 360 wrists was measured. The results differ from
      those previously published in the radiological literature. The difference may be
      explained by the small series' size or inadequate technical criteria used in
      previous studies.

PMID- 1027067
TI  - [Carcinoid tumor associated with osteoblastic metastasis and Cushing's syndrome].
AB  - This paper tries to group previous ideas related to: 1. The high possibility of
      metastatic disease to bone from carcinoid tumor to show a blastic pattern. 2.
      Cushing's syndrome can be secondary to non endocrine neoplasms. Both of these
      entities were present in the case being discussed which had a metastatic
      carcinoid but the primary site was not established.

PMID- 1027068
TI  - The masquerading effect of Paget's disease.
AB  - The record and roentgen findings in a patient with Paget's disease with
      coexisting multiple myeloma have been presented. Their rare or even unique
      association is recorded to refresh ones recollection that patients with Paget's
      disease may be host to a second disease, which if recognized, may be of
      inestimable profit to the medical care and comfort of the patient.

PMID- 1027069
TI  - The radiologic hypertensive evaluation.

PMID- 1027070
TI  - Kaposi's sarcoma in bone: a case report with unusual radiographic findings and an
      abnormal radioisotope scan.
AB  - The authors present a case report of Kaposi's sarcoma involving the bones of the
      forearm, wrist, and hand. Typical features of rarefaction, osteoporosis, cysts,
      and cortical erosions were present. Rarely seen changes of a bubbly expansion of
      the lesions and periosteal reaction were also present. This is the first
      radioisotope bone scan reported in Kaposi's sarcoma to the author's knowledge.
      The literature about osseous manifestations of Kaposi's sarcoma is reviewed.

PMID- 1027071
TI  - An argument for epinephrine renal arteriography in the diagnosis of renal cell
      carcinoma.
AB  - Two cases are presented where the diagnosis would have been missed or would have
      been very difficult with selective angiography only; the use of the epinephrine
      technique made these renal cell carcinomas obvious. The authors feel that
      epinephrine should be used in the presence of all renal masses to exclude or
      confirm the presence of renal cell carcinoma if this is not already obvious by
      selective arteriography alone.

PMID- 1027072
TI  - Theoretical considerations in the use of contrast media for computed cranial
      tomography.
AB  - The impressive results obtained by the use of iodinated contrast media,
      particularly when administered by drip infusion technique, led us to investigate
      the advantages and disadvantages of the method. An originally non-invasive
      examination has progressively evolved into a quasiinvasive examination in the
      majority of cases, and our results appear to justify such a trend.

PMID- 1027073
TI  - [Study of fear of flying].

PMID- 1027074
TI  - [Interposition of an inverted intestinal segment in extensive resections of the
      small intestine. (Experimental study of morphological changes induced in the
      residual small intestine with the prophylactic or therapeutic use of the method].

PMID- 1027075
TI  - [Medical physiological problems caused by supersonic transport planes].

PMID- 1027076
TI  - [Use of Pescador's 3d precordial lead in the detection of latent cardiac
      pathological conditions in Air Force personnel].

PMID- 1027077
TI  - [Psychological aspects and problems in selection of selectors].

PMID- 1027078
TI  - [Medicolegal problems in the investigation of flight accidents].

PMID- 1027079
TI  - [Cardiovascular diseases as a cause of unfitness for flying in flight personnel:
      etiopathogenesis and prevention].

PMID- 1027080
TI  - [Use of the human centrifuge for training military pilots in the execution of
      anti-G maneuvers].

PMID- 1027081
TI  - [Personal identification of victims of aviation disasters].

PMID- 1027082
TI  - [Public health study in the province of Badajoz].

PMID- 1027083
TI  - [Urinary excretion of tetracycline (tetracontrol of excretion) in cancer
      patients. An early diagnostic test?].

PMID- 1027084
TI  - [Results of the standard tuberculin test in patients with cancer].

PMID- 1027085
TI  - [Biochemical changes in the white rat with Trichinella spiralis parasitosis.
      Experimental study].

PMID- 1027086
TI  - [New method for the identification of slow-growing mycobacteria. Use of a
      numerical code].

PMID- 1027087
TI  - [Report on meningococcic meningitis. I. Description of the epidemiologic
      situation in 1975].

PMID- 1027088
TI  - [Report on typhoid fever. I. Report of the epidemiologic situation in 1975].

PMID- 1027089
TI  - [Report on brucellosis].

PMID- 1027090
TI  - [Etiology of infections due to respiratory virus in hospitalized children in
      Barcelona during 1969-1974].

PMID- 1027091
TI  - [Survey on nutrition and diet in Almaden (Ciudad Real). May 1976].

PMID- 1027092
TI  - [Scabies. Incidence and epidemiologic considerations in the region of Asturias].

PMID- 1027093
TI  - [The rural dwelling as a disadjustment phenomenon].

PMID- 1027094
TI  - [Introduction of a numerical code for the taxonomic study of Pseudomonas
      species].

PMID- 1027095
TI  - [The teaching of clinical oncology in oncological hospitals].

PMID- 1027096
TI  - A coxsackievirus type A24 epidemic of acute conjunctivitis.
AB  - The 1975 epidemic of acute conjunctivitis was caused by the return of S.E.C. 1970
      virus (CA24). The clinical manifestations of cases seen in the recent epidemic
      were similar to those seen during the 1970 epidemic caused by S.E.C. 1970 virus
      (CA24) and the 1971 epidemic caused by S.E.C. 1971 virus (entero-virus type 70).
      In our opinion, both the S.E.C. 1970 VIRUS (CA24) and S.E.C. 1971 virus
      (enterovirus type 70) are equally important causes of epidemics of acute
      conjunctivitis more commonly known as the  "Acute Haemorrhagic Conjunctivitis".
      Although these two enteroviruses affect mainly the eye, apart from conjunctival
      secretions, they could be transmitted in respiratory droplets and faeces. The
      authors would prefer to retain the term "Picornavirus Epidemic Conjunctivitis" to
      denote infection by S.E.C. 1970 virus (CA24) and S.E.C. 1971 virus (enterovirus
      type 70).

PMID- 1027097
TI  - Acquired toxoplasmosis in Malaysia.
AB  - Two cases of acquired toxoplasmosis in asymptomatic Malaysian patients are
      described. In both instances the diagnosis was first made on the finding of the
      Piringer-Kuchinka reaction in excised lymph nodes from these patients and
      serological studies further confirmed the presence of hihg toxoplasmic antibody
      titres. The characteristic histological features of toxoplasmic lymphadenitis are
      discussed. Diagnosis and management of the disease are briefly reviewed with
      emphasis that the importance of diagnosing this disease goes beyond the
      establishment of a mostly self-limiting, clinically unimportant protozoan
      infection.

PMID- 1027098
TI  - A study of the noise hazard in selected industries in the Philippines.
AB  - A study was made to evaluate the noise hazard in certain industries of the
      country. Evaluation was made by measuring the noise levels at the work sites of
      different establishments and the hearing acuity of workers in the textile mill
      and the steel plant. It was found that noise levels were quite high varying from
      86 to 119 decibels. Most of the energies of noise were centered in the middle and
      high frequencies denoting potential danger to the hearing apparatus. Audiometric
      results revealed hearing losses for workers exposed to excessive noise even when
      corrected for age. This suggests that the hearing defects were noise-induced. As
      a consequence of the results it is necessary for the industries surveyed to
      institute hearing conservation programs to protect the health and welfare of the
      workers.

PMID- 1027099
TI  - Acarine ectoparasites of small mammals in Jakarta, Indonesia.

PMID- 1027100
TI  - Immunological means of separating third-stage larvae of Ancylostoma tubaeforme
      and A. caninum.

PMID- 1027101
TI  - Serum vitamin B12 level in pregnancy.

PMID- 1027102
TI  - Echinocephalus uncinatus in Pentapodus setosus (threadfin bream), a marine fish
      caught from the Gulf of Thailand.

PMID- 1027103
TI  - Experimental attempts to induce ocular infection in cats with subperiodic Brugia
      malayi.
AB  - In an attempt to determine whether the finding of human ocular lesions due to B.
      malayi was due to the site of entry of the infective larvae, cats were infected
      via ocular instillation, subconjunctival inoculation, subcutaneous inoculation
      around and infective mosquito bites over the eyes. Although no conjunctival
      lesion was seen patent infections were produced via ocular instillation,
      subconjunctival and subcutaneous inoculation of infective larvae. Adult worms
      were also recovered from periorbital tissues. Adult worms were localized mainly
      in the lymphatic system of the head and neck regions of the cat. The results show
      that the conjunctival lesions seen in humans could be due to the site of bite of
      the mosquito and thus the entry of the infective larvae.

PMID- 1027104
TI  - Growth and localization of Angiostrongylus cantonensis in the molluscan host,
      Achatina fulica.
AB  - The development of the rat lung worm  Angiostrongylus cantonensis within the
      giant African snail Achatina fulica is reported. In this host, ingested first
      stage larvae penetrate the intestinal wall into the hemocoel and migrate to the
      mantle where they undergo two molts and become third stage larvae within 24 days.
      The mantle, harboring 85% of the total number recovered is the major location of
      infective larvae. The kidney contains about 11% but few larvae are found in the
      remaining visceral organs. Host response consists of encapsulation; destruction
      by means of phagocytosis was not observed.

PMID- 1027105
TI  - The freshwater snail lymnaea rubiginosa as an experimental host of
      Angiostrongylus malaysiensis: a preliminary report.
AB  - Preliminary studies have shown that Lymnaea rubiginosa, a common fresh-water
      snail in Peninsular Malaysia, which is easily colonized and reared in the
      laboratory, is a capable experimental intermediate host for Angiostrongylus
      malaysiensis. Overall 73% of the snails tested became infected following 6 hours
      exposure to infective rat faeces. Higher infection rates, up to 100%, and heavier
      worm loads, occurred among the larger sized snails. Snail attrition was low
      except when very heavy worm loads were acquired.

PMID- 1027106
TI  - The bandicoot rat, a new host record for Angiostrongylus cantonensis in
      Indonesia.
AB  - A survey for Angiostrongylus cantonensis in possible definitive and intermediate
      hosts was conducted in Ancol, Jakarta. Adult worms were found in 43% of bandicoot
      rats, Bandicota indica setifera, in 14% of Rattus rattus diardii and 36% of the
      Achatina fulica were infected with larval forms of the parasite. The finding of
      the parasite in the bandicoot rat constitutes a new host record for Indonesia.

PMID- 1027107
TI  - Morphology of Ancylostoma buckleyi Le Roux and Biocca, 1957 in dogs from Cairns,
      North Queensland, Australia.
AB  - Ancylostoma buckleyi was found in dogs in Cairns, North Queensland, Australia.
      Worms were small, whitish, males 10.25-10.89 mm in length; females 12.65-14.96 mm
      in length. The buccal capsule was funnel shaped. There were three pairs of
      ventral teeth and two pairs of dorso-lateral teeth. Spicules were simple and
      equal, 0.71-0.73 mm in length. Gubernaculum was shaped like a cricket bat, the
      widest part in the posterior half. The bursa was well developed, the ratio
      between posterolateral-mediolateral to mediolateral-externolateral was 1:1. The
      inner branches of the dorsal rays were partially fused. Tail of the femaleworm
      was 0.22-0.23 mm in length and conical.

PMID- 1027108
TI  - Schistosomiasis japonica in field rats in Leyte, Philippines.
AB  - Approximately 73% of wild caught field rats were found infected with
      schistosomiasis japonica as revealed by the finding of eggs in liver sections;
      49% of rats showed eggs in histological sections of the large intestine and about
      13% showed eggs in their stools. Male rats appear to have higher schistosomiasis
      infection rate then female rats and that rats caught from endemic areas with
      smooth or normal looking livers do not necessarily mean that they are not
      infected with schistosomiasis. Examination for miracidia using only 2-3 pellets
      of field rat's stool by Faust-Meleney egg hatching technique revealed that 58% of
      them were positive with a mean of 5 miracidia per rat. A slightly lower
      hatchability rate was observed among laboratory infected white rats. Our figures
      on hatchability of Schistosoma ova are higher than those obtained by Pesigan and
      his co-workers probably because we used freshly collected rat faeces.

PMID- 1027109
TI  - Control of Culex pipiens fatigans(W) by the larvivorous fish Poecillia reticulata
      and by removal of debris from the breeding habitat.
AB  - Twice weekly removal of floating debris from two polluted ponds in Bangkok
      resulted in 75% reduction of immature populations of C.p. fatigans for seven
      weeks. Subsequent introduction of the guppy Poecilia reticulata at 10 fish per m2
      further reduced the aquatic population to 2% of the pretreatment level during 12
      weeks. When debris removal was discontinued, partial recovery of the larval
      density was observed. When fish were introduced in a plot without prior debris
      removal, there was no reduction of the mosquito population, and when only part of
      the debris was removed from one plot, the reduction was immediate.

PMID- 1027110
TI  - Epidemic appearance of a new influenza strain in Asia.
AB  - An outbreak of influenza associated with increased absenteeism among school-age
      children occurred during May and June 1975 in Tapei, Taiwan. The virus strain has
      recently been shown to be antigenically similar to A/Victoria/3/75 which is now
      active in other areas of the Pacific.

PMID- 1027111
TI  - The effects of climatic patterns and agricultural practices on the population
      dynamics of Culex tritaeniorhynchus in Asia.
AB  - Annual population curves for C. tritaeniorhynchus are presented for
      representative localities distributed from Pakistan, east through Southeast Asia
      and the Philippines and north to Japan and Korea. In the dry temperature
      (Pakistan) and colder maritime climates (Japan and Korea). C. tritaeniorhynchus
      populations apparently overwintered as hibernating adults, while in the warmer
      maritime climates (Okinawa and Taiwan), gonotrophic activity and larval
      development continued throughout the winter months. In these climatic types, the
      population curves closely paralleled the annual temperature curves. In the
      tropical climates, however, temporal population patterns were closely related to
      available moisture either in the form of annual precipitation and/or rice
      irrigation. The extremely variable environmental conditions tolerated C.
      tritaeniorhynchus throughout its distribution attests to the physiological and
      ecological plasticity of this species and suggests that further ecological and
      genetic studies may reveal marked clinical variances among selected biological
      parameters.

PMID- 1027112
TI  - Juvenile rheumatic fever and rheumatic heart disease at Ramathibodi Hospital,
      Thailand.
AB  - One hundred consecutive cases of rheumatic fever and rheumatic heart disease who
      were seen at Department of Pediatrics. Ramathibodi Hospital were reviewed.
      Particular attention was given to the pattern and the outcome of the cardiac
      status of the patients. The high incidence of severe carditis and tight mitral
      stenosis was similar to most reports from other developing countries. There was a
      poor prognosis for the cardiac status of those who came late, had more than
      valvular lesions, were in congestive heart failure, or had preexisting heart
      disease and atrial fibrillation. In spite of this, 6 patients had no evidence of
      heart disease after being followed up for less than 5 years.

PMID- 1027113
TI  - Mebendazole and pyrantel pamoate as broad-spectrum anthelmintics.
AB  - The efficacy of mebendazole and pyrantel pamoate was studied in two groups of 59
      and 58 cases, respectively, of patients with polyparasitosis. Mebendazole had a
      cure rate of 96%, 82.2%, 71.4% and 66.6% in A. lumbricoides, hookworm, T.
      trichiura and S. stercoralis, respectively, while the corresponding figures for
      pyrantel pamoate were 92.6%, 85.7%, 19.4% and 0%. Pyrantel pamoate is considered
      to have no significant effect on T. trichiura and S. stercoralis. None of the
      drugs had any effect on  T. saginata. Both drugs have been found to be equally
      effective against enterobiasis by various authors. It is recommended that
      pyrantel pamoate be the drug of choice in cases of multiple parasitic infections
      excluding T. trichiura and S. stercoralis whereas those with one or both of these
      in addition to others should be treated with mebendazole. Mebendazole can be
      prescribed for patients with clinical evidence of helminthic infections even
      where stool examination is not possible as it covers almost the whole range of
      common helminthic infections. The only limitation for poorer patients however is
      its cost. Pyrantel pamoate has a wider applicability for the poorer patients in
      spite of the fact that it is ineffective against trichurids and S. stercoralis.

PMID- 1027114
TI  - A survey of houseflies in bangkok and neighboring provinces.
AB  - A survey of flies in Bangkok and neighboring province revelaed that among 8,675
      flies collected there were 10 genera and 18 species of flies, eg. Musca
      domestica, M. bezzii, M. conducens, M. nebulo, Chrysomyia megacephala, C.
      rufifacies, Phaenicia sericata, P. cuprina, Sarcophaga ruficornis, S. peregrina,
      S. orchidae, S. albiceps, Megaselia scalaris, Lispe orientalis, Anaclysta flexa,
      Morellia hortensia, Hemipyrellia ligurriens and Orthellia coeruleifrons. Musca
      mostly bred in low-protein content media, eg., garbage piles of vegetable and
      rice, and was predominant in the morning while Chrysomyia and Phaenicia mostly
      bred in high-protein content media, eg., animal carcasses, and were predominant
      in the afternoon. Female flies were bigger than male and they were more
      predominant than males in or around breeding places. The density of flies was
      correlated with the relative humidity but not with rainfall or temperature. The
      density of flies was correlated with the occurrence of gastrointestinal diseases.
      Some cases of myiasis have been reported from Thailand.

PMID- 1027115
TI  - Prevalence of heart disease in school children in Thailand: a preliminary survey
      at Bang Pa-in.
AB  - A total of 2,764 students were examined from five schools in Bang Pa-in,
      district, Ayutthaya Province, Thailand; 12 were found to have heart disease, a
      prevalence of 4.34 per thousand examined. Of these 4 cases were known by their
      parents to have heart disease prior to our study. The prevalence of congenital
      heart disease was 3.3 and of rheumatic heart disease 1 per thousand students. The
      incidence of functional heart murmur was 46%. The prevalence rate of heart
      disease in Thai school children was similar to rates in reports from Canada,
      America and Iran.

PMID- 1027116
TI  - Contributions to natural sources and methods of transmission of Gnathostoma
      spinigerum in Thailand.

PMID- 1027117
TI  - [Value of the study of liver siderosis in acute viral hepatitis].

PMID- 1027118
TI  - [Hereditary hypertrophic neuropathies--clinico-histopathological study].

PMID- 1027119
TI  - [Obstructive papillomatosis of the larynx in adult patients].

PMID- 1027120
TI  - [Role of radiation therapy in the treatment of malignant tumors of the salivary
      glands].

PMID- 1027121
TI  - [Encopresis].

PMID- 1027122
TI  - [Psittacosis, Bence-Jones proteinuria and vasculitis].

PMID- 1027123
TI  - [Pulmonary emphysema. Report of a case].

PMID- 1027124
TI  - [Submandibular actinomycotic abscess].

PMID- 1027125
TI  - [Contractions of the pectoral musculature in hemisparesis].

PMID- 1027126
TI  - [Improvements in the public health status in Mexico during 1974].

PMID- 1027127
TI  - [Changes of various mortality indices in Latin America].

PMID- 1027128
TI  - [Mortality by cause in the city of Veracruz in 1975].

PMID- 1027129
TI  - [Congenital toxoplasmosis, a medicosocial problem].

PMID- 1027130
TI  - [Results of the tuberculosis control program at the Mexican Institute of Social
      Security].

PMID- 1027131
TI  - [The traditional midwife: can she be incorporated into a national materno
      infantile-health and family-planning program?].

PMID- 1027132
TI  - [Balanolysis as a substitute of circumcision].

PMID- 1027133
TI  - [Psychiatric hospitalization in a social security system (Instituto de Seguridad
      Social y Servicios Sociales de los Trabajadores del Estado)].

PMID- 1027134
TI  - [Supervision of medical services].

PMID- 1027135
TI  - [Medical care in Mexico as seen by the Mexican physicians].

PMID- 1027136
TI  - [Vital statistics of the city of Guadalajara, 1974-1975].

PMID- 1027137
TI  - Transcendence of the correct selection of the basic cause of death.

PMID- 1027138
TI  - [Mortality rate by infectious and parasitic diseases in the city of Veracruz in
      1970 and in 1975].

PMID- 1027139
TI  - [Experience with the intraterine device in the Programa de Planificacion Familiar
      de la Secretaria de Salubridad y Asistencia 1973-1974].

PMID- 1027140
TI  - [Arsenic poisoning in cattle. Poison control and health hazards].

PMID- 1027141
TI  - [Project of a solar water heating system. An experiment in the use of solar
      energy in developing countries].

PMID- 1027142
TI  - [Persistence of transplacental immunity against measles. Considerations on the
      importance of the national immunization program].

PMID- 1027143
TI  - [Tuberculin test].

PMID- 1027144
TI  - [Leptospirosis in the state of Chiapas, Mexico (preliminary report)].

PMID- 1027145
TI  - The effect of specific antiserum on the metabolism of three membrane-associated
      antigens of ASL-1 x LM(TK)- hybrid cells.
AB  - Fusion of ASL-1 cells, a murine leukemia forming thymus leukemia (TL) antigens,
      with LM(TK)- cells, a TL(--) murine cell line, resulted in a stable hybrid
      forming TL antigens. The hybrids failed to undergo modulation, the reversible
      dissappearance of TL antigens from the surfaces of the cells, stimulated by TL
      antiserum. Unlike ASL-1 cells, the rate of disappearance of the antigens from
      modulation negative hydrid cells was unaffected by TL antiserum. The t 1/2 of TL
      antigens of the hybrid was approximately 30 h. The t 1/2 of TL antigens of ASL-1
      cells was 10 h in the presence of TL antiserum, 18 h in the absence of TL
      antiserum. The rate of metabolism of a putative tumor-associated antigen of ASL-1
      cells formed by the hybrid was unaffected by exposure to specific antiserum, as
      was the metabolism of H-2 antigens formed by the cell types.

PMID- 1027146
TI  - The selection of somatic cell hybrids between human lymphoma cell lines.
AB  - Somatic cell hybrids have been selected between three pairs of established human
      lymphoid cell lines producing  pure lines of proliferating hybrid cells:
      Raji/Namalwa, Raji/Daudi, and Raji/BJAB. The hybrid cell lines have been
      characterized with respect to isozyme pattern, volume, and karyotype.

PMID- 1027147
TI  - The selection of Chinese hamster cells deficient in oxidative energy metabolism.
AB  - A selection scheme based on the nutritional requirements of a previously
      described respiration-deficient Chinese hamster line has been used to isolate new
      mutants defective in oxidative energy metabolism. Three of the primary
      characteristics of this type of mutant are (1) a strict dependency on the
      continued presence of glucose for survival; (2) a drastic reduction in the rate
      of oxygen consumption; (3) an inhibition of Krebs cycle activity resulting in
      auxotrophy for asparagine and carbon dioxide. In the case of one cell line which
      was used (V79), up to 65% of the survivors of a selection were found to possess
      this phenotype after only one round of selection. By contrast, it proved much
      more difficult to obtain such mutants from another cell line (CCL16). A
      preliminary characterization of a number of these mutants is presented.

PMID- 1027148
TI  - Transfer of the human X chromosome to human--Chinese hamster cell hybrids via
      isolated HeLa metaphase chromosomes.
AB  - Evidence is presented for the uptake of the human X chromosome by human-Chinese
      hamster cell hybrids which lack H P R T activity, following incubation with
      isolated human HeLa S3 chromosomes. Sixteen independent clonal cell lines were
      isolated in H A T medium, all of which contained a human X chromosome as
      determined by trypsin-Giemsa staining. The frequency of H A T-resistant clones
      was 32 x 10(-6) when 10(7) cells were incubated with 10(8) HeLa chromosomes.
      Potential reversion of the hybrid cells in H A T medium was less than 5 x 10(-7).
      The 16 isolated cell lines all contained activity of the human X-linked marker
      enzymes H P R T, P G K,alpha-Gal A, and G6PD, as determined by electrophoresis.
      The phenotype of G6PD was G6PD A, corresponding to G6PD A in HeLa cells. The
      human parental cells used in the fusion to form the hybrids had the G6PD B
      phenotype. The recipient cells gave no evidence of containing human X
      chromosomes. These results indicate that incorporation and expression of HeLa X
      chromosomes is accomplished in human-Chinese hamster hybrids which lack a human X
      chromosome.

PMID- 1027149
TI  - A CHO-cell mutant with a defect in cytokinesis.
AB  - In a selection procedure designed to enrich for temperature-sensitive mutant
      cells blocked in mitosis a CHO-cell mutant was isolated which has a defect in
      cytokinesis as the basis of its temperature-sensitive phenotype. Cultures of the
      mutant had an abnormally high percentage (ie. 34%) of polyploid cells at the
      permissive temperature of 34 degress C and showed further increased frequencies
      of polyploidy as well as many multinucleated cells at 38.5 degrees 39.5 degrees.
      When the mutant cells were synchronized in metaphase by Colcemid arrest and then
      placed into fresh medium at nonpermissive temperature, they did not divide
      although the completion of mitosis appeared cytologically normal. Ultrastructural
      examination by electron microscopy of such synchronized cells at telophase
      revealed no specific defects in cellular components other than failure of
      development of a normal midbody. The sensitivity of the mutant to cytochalasin B
      and to Colcemid was the same as for wild-type cells. This mutation behaved as
      recessive in tetraploid cell hybrids constructed by fusing the mutant with a CHO
      strain which was wild-type with respect to temperature sensitivty.

PMID- 1027150
TI  - Assignment of a structural gene for beta-glucuronidase to human chromosome C7.
AB  - An electrophoretic technique was developed which allows the separation of human
      beta-glucuronidase (GUS EC 3.2.1.3.1) from the enzyme present in cultured murine.
      Chinese and Syrian hamster cells in one buffer system on Cellogel. Using this
      technique a number of independent human-mouse somatic cell hybrids have been
      analyzed for the segregation of GUS, other enzyme markers, and all human
      chromosomes. The results indicate that a structural gene for human beta
      glucuronidase is located on chromosome C7.

PMID- 1027151
TI  - Inhibition of the growth of mammalian cells in cuture by amino acids and the
      isolation and characterization of L-phenylalanine transport.
AB  - Raising the concentration of phenylalanine and other amino acids in MEM leads to
      the inhibition of growth and in some cases to death of A9. Balb 3T3 , SV40 Balb
      3T3 (SVT2), CHO, and WI38. All cells tested exhibited some similar senstivities
      to certain of the amino acids. but there were some unique differences.
      Phenylalanine-resistant mutants (Pher) of A9 were isolated that had modified
      phenylalanine-transport properties. These mutants can be isolated by a single
      step selection procedure. A Lineweaver-Burk plot of initial rates of
      phenylalanine uptake by A9 and mutants showed a biphasic curve suggesting two
      transport systems. The Pher mutants had altered properties of both systems. It is
      suggested that the selection of clones resistant to high concentration of several
      of the natural amino acid may be used as a general method for the isolation of
      mutants affecting the various amino acid transport systems in mammalian cells.

PMID- 1027152
TI  - Isolation and characterization of 5-fluorotryptophan-resistant mutants with
      altered L-tryptophan transport.
AB  - Mutants of A9 mouse fibroblast, resistant to the killing effect of 0.4 mM 5
      flurotryptophan (5-FT), have altered L-tryptophan transport properties. The
      resistant phenotype is stable for at least 90 generations of growth in MEM. A
      fluctuation test indicated that clones resistant to 0.4 mM 5-FT occurred
      spontaneously. An average mutation rate was estimated at 1.6 X 10(-6). Treatment
      with N-methyl-N'-nitro-N-nitrosoguanidine increased the frequency of these clones
      by at least 100-fold. These results indicate that the resistant clones arose as a
      result of a mutation. All the resistant mutant tested accumulate less 5-FT at
      near steady-state conditions than the wild type. Lineweaver-Burk plots of initial
      rates of tryptophan uptake yield a biphasic curve suggesting that tryptophan is
      transported by two transport systems. Kinetic constants determined by a computer
      program indicate that both proposed transport systems were modified in each of
      two 5-FT resistant mutants.

PMID- 1027153
TI  - Mutant alleles for hypoxanthine phosphoriboxyltransferase: codominant expression,
      complementation, and segregation in hybrid Chinese hamster cells.
AB  - Chinese hamster ovary cell mutants resistant to the purine analogs 6-thioguanine
      or 8-azaguanine have been isolated following mutagenesis with ethyl methane
      sulfonate. The activities of hypoxanthine phosphoribosyltransferase (HPRT) in
      three such mutants have been found to exhibit an increased Km for the substrate 5
      phosphoribosyl-1-pyrophosphate. The isoelectric point of the mutant enzyme
      activity has also changed in two mutants. Hybrid cells containing one mutant and
      one wild-type allele express both genes. Segregants that have lost only the wild
      type allele can be selected on the basis of drug resistance. Two mutants
      exhibiting different alterations in HPRT activity can complement in a hybrid cell
      to yield a wild-type growth pattern and enzyme activity with intermediate
      electrophoretic and kinetic properties. The results suggest intracistronic
      complementation between structural gene mutants of HPRT.

PMID- 1027154
TI  - Inhibition of biological effects of bromodeoxyuridine by deoxycytidine:
      correlation with decreased incorporation of bromodeoxyuridine into DNA.
AB  - The effects of 5-bromodeoxyuridine (BrdU) on pigmentation, contact inhibition,
      cell morphology, and tumorogenicity of Syrian hamster melanoma cells are
      inhibited in the presence of deoxycytidine (dC). The inhibition of these
      biological effects of BrdU by dC is correlated with a decrease in the
      incorporation of BrdU into nuclear DNA. The results suggest that the
      intracellular changes resulting from the addition of dC to cells in the presence
      of BrdU are comparable to those resulting from a decrease in the concentration of
      BrdU in the medium.

PMID- 1027155
TI  - [Enzymatic studies in threatened abortion].

PMID- 1027156
TI  - [Sexological reflections concerning the sex act].

PMID- 1027157
TI  - [Coloring cells of the cornea of trout].
AB  - Cells from the eye cornea of Hexagrammos octagrammus which are responsible for
      changes of the cornea colour from bright orange to colourless, depending on the
      light conditions, are described. It was shown that the change in cornea colour
      was due to a shift of red pigment from the cell body into its processes (in the
      light) and in the opposite direction at the dark adaptation of animals. The
      ultrastructural constitution of these cells has a number of characteristics. The
      whole cell cytoplasm is filled up with fine lipid droplets wherein carotenoid
      pigments giving red colour to these cells are presumably dissolved; the
      cytoplasmic membrane forms numerous deep and branched folds into the cell and has
      a lot of pinocytose visicles; the cell body and especially the process display
      many microtubes arranged regularly. The described cells differ greatly in their
      form, size and ultrastructural constitution from the known types of pigment cells
      (melanophores, xanthophores and erythrophores). This makes it possible to
      consider them as chromatophores of an independent type.

PMID- 1027158
TI  - [Phagocytic activity and reproduction of the trophoblast cells in the embryo of
      albino rat].
AB  - The phagocytic activity of primary and secondary giant cells of the white rat's
      trophoblast was studied in the course of differentiation. The highest activity
      occurs in the initial period of the foetus implantation to last within a limited
      time for 5--6 days. Both quantitative and qualitative differences were detected
      in phagocytic activities of the trophoblast cells during their growth. A question
      is discussed of the time synchronism between the phagocytic activity and the
      trophoblast cells polyploidization.

PMID- 1027159
TI  - [Incorporation of H3-thymidine into the oocytes of a sterlet in the early meiotic
      prophase].
AB  - DNA synthesis in meiotic oocytes of the sterlet (A. ruthenus) has been studied
      during early prophase stages using H3-thymidine. The pattern of H3-thymidine
      incorporation is similar to that in oocytes of Amphibia and Osteichthyes. In the
      oogonia as well as in the leptotene and zygotene oocytes, the label is
      predominantly localized over chromosomes. An intensive incorporation of H3
      thymidine into the material of the heterochromatic "cap" has been observed during
      pachytene. Thus, the main synthesis of extra DNA in the sterlet oocytes occurs
      during pachytene. No DNA in synthesized by the diplotene oocytes.

PMID- 1027160
TI  - [Behavior of holokinetic chromosomes in the spermatogenesis of bugs].
AB  - Chromosomes were studied on the spermatogonial metaphase and on different stages
      of meiotic division in males of Eurydeme geblery Kol. and E. ventrale Kol. The
      set of male chromosomes of the above species involves six pairs of autosomes and
      an XY sex pair, which is commonly the case in Pentatomidae. In the
      spermatogenesis, division types are reductional for autosomes and equational for
      sex chromosomes in the first metaphase; but the situation is quite opposite in
      the second metaphase. The sex chromosomes of bugs undergo a "touch and go"
      pairing on the metaphase plate of the second spermatocyte, prior to segregating
      to opposite poles in the anaphase that follows. No constrictions occur along all
      the chromosomes at mitosis. This, combined with their behaviour at mitosis, may
      suggest that, likely as in other Hemiptera, the chromosomes are holokinetic.
      Nevertheless it is of interest to note that in meiosis the chromosomes behave as
      telocentric. This replacement of the holokinetic orientation by the telokinetic
      one in the meiosis of some organisms with diffuse centromere is supposed to
      depend on the phenomen called "construction of the kinetic activation".

PMID- 1027161
TI  - [Characteristics of DNA replication of the chromosomes of the bone marrow cells
      in patients with acute leukemia].
AB  - A study of the late DNA replication pattern in chromosomes of human acute
      leucaemia cells revealed a significant diffrence from control. Chromosomes, 2,3
      and 4-5 of the acute leucaemia cells finish their DNA replication earlier, and
      chromosomes 1, 13-15 and 16 later, compared to the control chromosomes. The
      difference in the pattern of DNA replication between analogous chromosomes of
      acute leucaemia and donor cells was associated with the discovery of large late
      replicating chromatin blocks in the pericentromeric regions of leucaemia cell
      chromosomes. Some relationship is suggested between the pattern of
      pericentromeric heterochromatin DNA replication and cell differentiation.

PMID- 1027162
TI  - [Effect of infectious factors on human and animal cytogenetic structures].
AB  - The analysis of blood leucocyte chromosomes has been carried out on 60 patients
      with different infectious diseases (influenza, measles, scarlet fever, and
      disentery), and on 47 patients immunized against measles, tick-born encephalitis,
      typhoid fever and brucellosis. The mutagenic influence of viruses on the genital
      cells of mice and on the human somatic cells in vitro was studied. Both viruses
      and bacteria appeared to be able to bring about different breaks in human and
      animal cells.

PMID- 1027163
TI  - [Effect of valinomycin on the structure of water-lecithin liposomes].
AB  - It has been established that water--lecithin liposomes in the heptane phase are
      formed in the course of equilibration of lecithin solution in heptane with water
      phase containing Na, K-picrate. The salts penetrate both the water nucleus of
      liposomes and their lecithin shell. The addition of valinomycin to this system
      does not change the water content in liposomes, but considerably increases the
      salt absorbed by the lipid shell of liposomes. A characteristic S-shape curve
      showing the relation between picrate extraction and the valinomycin concentration
      might be explained as an indication of a cooperative change of the structure of
      lecithin shell. This phase transition is induced by one valinomycin molecule per
      10(3)--10(4) lecithin molecules.

PMID- 1027164
TI  - [Heterogeneity and heat resistance of esterases of the pancreas and liver of
      rats].
AB  - A higher heat resistance of loosely-attached microsomal esterases as compared
      with that of free esterases of the rat's pancreas is due to a higher proportion
      of heat resistant slow carboxylesterases in the former. More significant
      differences in the heat resistance of pancreas and liver is caused not only by
      different heterogeneity of esterases, but also by their qualitative differences.

PMID- 1027165
TI  - [Cytogenetic study of continuous pig kidney cell cultures chronically infected
      with the Kilham virus].
AB  - A persistent infection of the continuous embryonal pig kidney cell cultures
      induced by a rat parvovirus (the Kilhem virus) did not alter morphological or
      karyological characteristics of the cultures, and caused no transformation of
      these. The data obtained suggests the resistance of the pig karyotype to the
      virus under investigation.

PMID- 1027166
TI  - [Study of the karyotype of the malaria mosquito].
AB  - A study of the karyotype composition of 22 geographycally removed natural
      populations of the malarial mosquito Anopheles messeae Fall revealed a
      chromosomal polymorphism characteristic of the whole species. 13 paracentric
      inversions were detected, no other gene arrangements being discovered. All the
      inversions can be divided into two classes: 1) wide spread inversions in hetero-
      and homozygous forms; 2) endemic ones discovered in individual populations in the
      form of heterozygotes. According to the presented photomap of salivary gland
      chromosomes, the inversion localization are as follows: IL1 (2a--4a), IL2 (1c-
      4a), IL3 (2a--3b), IL4 (1c--3b), IIR1 (7c--12c), IIR2 (10b--14b), IIL1 (15b-
      17a), IIIR1 (24a--26c), IIIR2 (23a--24c), IIIR3 (23b--25c), IIIR4 (27c--29c),
      IIIR5 (27d--30c), IIIL1 (34a--39d).

PMID- 1027167
TI  - [Study of mouse liver cell phosphorescence at deep cooling].
AB  - The spectrum and decay curves of phosphorescence of mouse liver cells at --180
      degrees C was studied using the phosphorescence microscope. The phosphorescence
      studied was shown to involve two components with different life spans. Part of
      either component in the total spectrum is estimated. A conclusion is made that at
      least two different centers (or groups of centers) exist in cells with the same
      spectral region of phosphorescence with highly diverging life times of triplet
      states.

PMID- 1027168
TI  - [Digital scanning-integrating cytospectrophotometer].
AB  - A principal scheme of the digital scanning and intergrating cytospectrophotometer
      is described which permits to measure the integrating optical density of
      specifically stained preparations, "spot" optical density of any absorbing
      preparations and the area of absorbing objects in two different levels of
      absorbtion.

PMID- 1027170
TI  - 1975 literature for trustees reflects new goals, unknowns.

PMID- 1027169
TI  - Malpractice: funding emerges as a critical issue.

PMID- 1027171
TI  - Can we afford national health insurance?

PMID- 1027172
TI  - A prescription for medical incompetence.

PMID- 1027174
TI  - Chairman's outlook: retreats for hospital trustees.

PMID- 1027173
TI  - HSAs: a way out of the regulatory mess?

PMID- 1027175
TI  - 'Leave us alone, we'll manage'.

PMID- 1027176
TI  - The end of the wobbly three-legged stool.

PMID- 1027177
TI  - What every trustee should know about medical audit.

PMID- 1027178
TI  - Public hospitals: how they got that way--and what can be done about it.

PMID- 1027179
TI  - Consensus on health policy eludes forum participants.

PMID- 1027180
TI  - Must doctors serve where they're told?

PMID- 1027181
TI  - The Darling case shows a silver lining.

PMID- 1027182
TI  - The trustee as advocate for society: a new perspective on quality of patient
      care.

PMID- 1027183
TI  - How hospitals are controlling costs.

PMID- 1027185
TI  - How to get doctors involved in governance, management.

PMID- 1027184
TI  - Doctors on boards: survey tracks a growing trend.

PMID- 1027186
TI  - Should trustees serve on medical staff committees?

PMID- 1027187
TI  - 'A sound mind in a sound body' is aim of executive health institute.

PMID- 1027188
TI  - Malpractice: simple solution eludes tort reformists.

PMID- 1027189
TI  - Hospital costs: the reason is people.

PMID- 1027190
TI  - In trustee education, Tennessee shows the way.

PMID- 1027191
TI  - Is there a merger in your future?

PMID- 1027192
TI  - Chairman's outlook: utilization of volunteers.

PMID- 1027193
TI  - Public needs voice in hospitals.

PMID- 1027194
TI  - The Quinlan precedent.

PMID- 1027195
TI  - Research with human subjects: trustees should ask questions.

PMID- 1027196
TI  - [Chemical composition of propolis].

PMID- 1027197
TI  - [Diagnosis of acute poisoning of animals with amiphos].

PMID- 1027198
TI  - [Toxicity of oxide].

PMID- 1027199
TI  - [Toxic effect of phosphamide and methylnitrophos on chickens].

PMID- 1027200
TI  - [Distribution and concentration of ampicillin in the body of chickens].

PMID- 1027201
TI  - [Natural immunity of animals and methods of its determination].

PMID- 1027202
TI  - [Serological evaluation of post-vaccinal immunity to Newcastle disease].

PMID- 1027203
TI  - [Cooperation of USSR and United States in veterinary medicine].

PMID- 1027204
TI  - [Temperature regulation and ventilation in raising of chickens].

PMID- 1027205
TI  - [Effect of noise on the body of birds].

PMID- 1027206
TI  - [Effect of artificial molting on the resistance of chickens].

PMID- 1027207
TI  - [Bone flour in chickens' nutrition].

PMID- 1027208
TI  - [Carcass cremation furnace for poultry farms].

PMID- 1027209
TI  - [Study of the viruses ecologically connected with birds].

PMID- 1027210
TI  - [Pathogenesis of influenza in immune and intact chickens].

PMID- 1027211
TI  - [Current characteristics of epizootiology of rabies].

PMID- 1027212
TI  - [Biotest in viral (transmissible) gastroenteritis of swine].

PMID- 1027213
TI  - [Control of ectoparasites of chickens].

PMID- 1027214
TI  - [Tylosin in the treatment of spirochete infections in chickens].

PMID- 1027215
TI  - [Effect of vaccination on the reproductive function of animals].

PMID- 1027216
TI  - [Protein and iodine metabolism in the regulation of sexual function in cows].

PMID- 1027217
TI  - [Effectiveness of therapy of mastitis].

PMID- 1027218
TI  - [Use of masticide in latent mastitis].

PMID- 1027219
TI  - [Meisseria infection of the reproductive organs in geese].

PMID- 1027220
TI  - [Milk analysis in diagnosis of ketosis in cows].

PMID- 1027221
TI  - [Analgesia of the udder in cows].

PMID- 1027222
TI  - [Treatment in case of incarceration of the head of a magnetic probe in the nasal
      cavity].

PMID- 1027223
TI  - [Clinico-anatomical manifestation of stomach ulcer of swine].

PMID- 1027224
TI  - [Pathomorphology of stomach ulcer in swine].

PMID- 1027225
TI  - [Clinico-biochemical indicators in the restorative period after physical
      exertion].

PMID- 1027226
TI  - [Effect of acetylsalicylic and 2,3-dihydroxybenzoic acids on liver mitochondrial
      respiration in rats].
AB  - Acetylsalicylate (2-5 mM) inhibited phosphorylating (condition III) and uncoupled
      respiration of rat liver mitochondria in vitro, when succinate and glutamate were
      used as substrates of oxidation. Lower concentrations of acetylsalicylate did not
      cause the uncoupling effect. Antirheumatic drug 2,3-dihydroxybenzoate activated
      the phosphorylation in mitochondria, if it was added up to concentrations of 0.5
      5.0 mM for succinate and 0.5 mM for glutamate. An increase of 2,3
      dihydroxybenzoate concentration was accompanied by gradual inhibition of
      phosphorylating and uncoupled oxidation of succinate; activation of the
      respiration was completely abolished by addition of ADP, DNP and 2,3
      dihydroxybenzoate (20 mM). The data obtained suggest that the uncoupling effect
      of salicylate, which is formed by hydrolysis of acetylsalicylate in the organism,
      might be responsible for the toxic effect of the latter.

PMID- 1027227
TI  - [Enzymatic activity of the pentosephosphate pathway of carbohydrate conversion in
      the experimental therapy of dermatitis in rats].
AB  - An increase in the activity of 6-phosphogluconate dehydrogenase, transketolase,
      ribose-5-phosphatase and intensive conversion of glucose in pentosophosphate
      pathway in erythrocytes were observed in experimental rat contact dermatitis.
      Ultrasonic therapy was used (0.2 w/cm2 at impulse regimen of generator) for
      prevention and treatment of the dermatitis. Treatment of the dermatitis by
      ultraphonophoresis of sinalar was shown to be a suitable method, which caused the
      normalization of biochemical and structural processes in skin.

PMID- 1027228
TI  - [Glycogenolysis indices in the skeletal muscles of rats with experimental
      rickets].
AB  - Content of glycogen and lactic acid was decreased in sceletal muscles of growing
      male rats during the acute periof of experimental rachitis. In developing
      rachitis an increase in locomotions, maintained during the experimental period,
      fostered the normalization of these patterns.

PMID- 1027229
TI  - [Effect of Central Asian cobra (Naja naja oxiana) venom on the biosynthesis of
      nucleic acids and protein in animal cells].
AB  - Cobra poison at a dose of 4 microng/kg of body weight intensified the 3H
      thimidine incorporation into DNA of mice liver tissue; 20-40 microng/kg of the
      poison inhibited the incorporation. Single intraperitoneal administration of high
      doses of cobra poison (50-150 microng/kg) decreased the incorporation of 14C
      thimidine into DNA 1.2-1.9-fold. Little doses of the poison increased the
      incorporation of 14C-hydrolysate of Chlorella protein into proteins of liver
      cells and the high doses inhibited this process. Microdoses of cobra poison
      caused a distinct increase in weight of experimental mice.

PMID- 1027230
TI  - [Lactate dehydrogenase and glucose-6-phosphate dehydrogenase activity in the
      erythrocytes in diabetes mellitus].
AB  - In human erythrocytes activities of glucose-6-phosphate and lactate
      dehydrogenases were decreased approximately 2-fold in moderately severe and
      critical forms of diabetes mellitus, as compared with normal state. The lactate
      dehydrogenase activity was more distinctly decreased than the glucose-6-phosphate
      dehydrogenase activity. General medical treatment increased the activity of the
      enzymes (which catalyzed the ATP formation in erythrocytes) and normalized their
      relation.

PMID- 1027231
TI  - [Ubiquinone and cholesterol content and biosynthesis in the hypertrophied kidney
      of white rats following unilateral nephrectomy].
AB  - Within 3 days after dextralateral nephrectomy the weight of left kidney was
      increased by 24.0%, yield of mitochondrial protein--on the average, by 38.0%, the
      succinate dehydrogenase activity--by 40.0%. Content of ubiquinone was essentially
      unaltered in kidney within 3 days after the nephrectomy; in mitochondria
      concentration of the coenzyme (calculated per mg of protein) was decreased at the
      3-rd day after the operation. Biosynthesis of ubiquinone was increased at the 2
      nd day after the nephrectomy in slices of hypertrophied kidney; it was studied by
      incorporation of 1-14C-acetate. Biosynthesis of cholesterol was increased at the
      same time, especially within the 1-st and 2-nd days after the operation. Content
      of cholesterol was increased in hypertrophied kidney within the 3-rd day after
      the operation.

PMID- 1027232
TI  - [Effect of histidine on the malonic dialdehyde content in the tissues in
      experimental myocardial infarct].
AB  - Content of malone dialdehyde (product of peroxidative oxidation of fatty acids,
      estimated by the reaction with thiobarbituric acid) was increased in blood serum,
      cytoplasms, mitochondria of heart and liver tissues during the acute period of
      experimental myocardial infarction. After administration of histidine
      concentration of malone dialdehyde was distinctyly decreased in the tissues
      studied.

PMID- 1027233
TI  - [Fructose-1,6-diphosphate aldolase and ketose-1-phosphate aldolase isoenzyme
      spectra in the kidneys normally and in uranyl acetate poisoning].
AB  - Activities of both aldolases were distinctly decreased in acute kidney
      insufficiency, caused by administration of uranyl acetate. The decrease in the
      activity of fructose-1,6-diphosptate aldolase was more distinct which led to
      alteration in ratio between fructose -1,6-diphosphate and ketose-1-phosphate
      aldolases. The isozyme spectra of the enzymes were also altered. Isozymes of
      fructose-1,6-diphosphate aldolase AB2 and of ketose-1-phosphate aldolase form 22
      possessed the same electrophoretic mobility but their relative activity was
      increased 2-3-fold under conditions of the acute kidney insufficiency. At the
      same time, the more electrophoretically mobile isozymes were not detected.

PMID- 1027234
TI  - [Role of adrenergic mechanisms in the regulation of aspartate aminotransferase
      isoenzyme activity in the liver of white rats].
AB  - Cytoplasmic (c) and mitochondrial (m) isozymes of aspartate aminotransferase
      (AAT) (EC 2.6.1.1) were isolated from white rat liver tissue by means of
      electrophoresis in agar gel. For the enzymes Km values, pH optima were estimated
      and conditions, suitable for the reaction, were studied. On the basis of
      activating effectiveness on c-AAT the catecholamines were arranged in decreasing
      order as follows: adrenaline, isadrine, noradrenaline. Towards the m-AAT the
      series was: noradrenaline, isadrine, adrenaline. Obsidane decreased the action of
      adrenaline more effectively than it did isadrine. Phentholamine did not alter the
      effect of noradrenalin on c-AAT, but distinctly decreased the m-AAT activity.
      Beta-adrenergic receptor, but not alpha-receptor, participated in regulation of
      the AAT isozymes activity. Adrenaline promoted and isadrine inhibited the
      penetration of m-AAT into cytoplasma. Obsidane increased the effect of these
      catecholamines. After administration of phentholamine an increase in the AAT
      activity was caused by an increase in content of catecholamines in the organism.

PMID- 1027235
TI  - [Macroergic phosphates in the brain under hypoxia].
AB  - Acute hypoxic hypoxia ("height" 7000 m) did not cause distinct alterations in
      content of adenyl and guanyl nucleotides from brain tissue. Negative alterations
      in the pool of macroergic phosphates occurred in a deficit of oxygen ("height"
      8000 m). Short-term training with hypoxia prevented the alterations in nucleotide
      pool even if the extreme hypoxia was applied ("height" 9000 m). Pre-cooling of
      animals promoted the maintenance of nucleotide pool at the "height" of 8000 and
      9000 m. Hypothermia did not protect against the distinct alterations in content
      of both adenyl and guanyl nucleotides under conditions of oxygen deficit
      ("height" 9500 m and 1100 m).

PMID- 1027236
TI  - [Glycosaminoglycans of normal and pathologically altered articular cartilage].
AB  - Glycosaminoglycans of tegmental cartilage of human caput femoris were separated
      into the fractions, which were identified as keratosulfate, hyaluronic acid,
      heparitin sulphate, chondroitin-4-sulphate, chondroitin-6-sulphate, dermatan
      sulphate and heparin. Content of glycosaminoglycans in articular cartilage of
      healthy persons and patients with deforming arthrosis was determined. Content of
      sulphatated polysaccharides (dermatan sulphate, chondroitin-6-sulphate,
      keratosulfate and heparitin sulphate) was shown to be distinctly decreased in the
      cartilage of the patients as compared with the amount of the polysaccharides in
      the same tissue of healthy persons.

PMID- 1027237
TI  - [Increase in the lipid peroxide content in the blood and aortas of rabbits with
      experimental atherosclerosis].
AB  - Content of lipid peroxides was estimated in blood and aorta of intact rabbits by
      means of highly sensitive polarographic method, using a mercuric electrode.
      Content of lipoperoxides in blood and aorta was increased 4.4- and 3.6-fold,
      respectively, in animals with pronounced experimental atherosclerosis. The
      oxidation of lipoperoxides caused a distinct increase in content of
      intermolecular bindings in amino-containing phospholipids in aorta of rabbits
      with pronounced atheromatosis.

PMID- 1027238
TI  - [Catecholamine content in the adrenals in meningococcal infection].
AB  - Content of adrenaline and DOPA was distinctly decreased in adrenal glands of 32
      persons who died of meningitis, as compared with 7 persons, death of which was
      caused by trauma. The lowest content of catecholamines was found in cases of
      development of meningoencephalitis and also after massive hemorrhages into the
      adrenal glands. The alterations observed were due to impairment of the synthesis,
      secretion and probably, storage of biogenic amines in the adrenal medulla.

PMID- 1027239
TI  - [Study of the conditions for the breakdown of mixed disulfides between aminothiol
      protectors and cell proteins as factors that determine the stability of the
      disulfide bonds].
AB  - A glutathione reductase activity was unaltered in thymus and liver tissue and
      slightly increased in spleen of rats within 15-30 min after administration of a
      radioprotector mercaptoethylamine. At the same time an activation of unspecific
      disulphide reductase occured. The both enzymes participated in spliting of
      mercaptoethylamine disulphides coupled with proteins. The radioprotective
      effectiveness of the aminothiol was, though partially, due to development of
      these disulfides. Retention of disulfides between the protector and cell proteins
      could be extended up to 1 h. by administration of mercaptoethylamine into rats
      with decreased content of endogenous glutathione, caused by the previous
      treatment with cyclohexene.

PMID- 1027240
TI  - [Effect of hydrocortisone and insulin on the synthesis of ribonucleic acids in
      the nuclei and cytoplasm of the liver cells of sexually immature male rates].
AB  - A prolonged (within 4 days) administration of hydrocortisone or protamin-Zn
      insulin into preadolescent male rats with body weight of 70-90 g caused a
      distinct increase in the synthesis of DNA-like RNA, precursor of ribosomal RNA in
      nuclei and ribosomal RNA in cytoplasma of liver tissue. Protamin-Zn-insulin,
      after simultaneous administration with hydrocortisone, suppressed the increase in
      the synthesis of liver RNA fractions studied. The data obtained suggest that DNA
      like RNA, precursor of ribosomal RNA from nuclei and ribosomal RNA from
      cytoplasma of liver tissue of preadolescent male rats participate in the
      synthesis of transaminases in liver tissue. The signigicant role of androgenes
      was assumed to consist in carring out the inducing effect of glucocorticoids and
      insulin, which influenced to a variable degree the synthesis of DNA-like RNA, of
      ribosomal RNA precursors from nuclei and of ribosomal RNA from liver tissue
      cytoplasma in preadolescent and adult animals.

PMID- 1027241
TI  - [Change in the antioxidizing activity of the lipids during aging].
AB  - Antioxidative activity (AOA) of lipids in mice liver was decreased in the old
      animals. The rate of the AOA decrease varied in different strains of mice.
      Alteration in the AOA is a phenomenon typical, but unspecific, for the senescence
      process. Senescence belongs to the pathological states, which occur at the
      decreased level of the AOA. Similar alterations in AOA were noted in radiation
      disease, stress state, hyperoxia, intoxications. Development of these
      pathological states could be inhibited or prevented by means of substances,
      increasing the antioxidative activity. At the same time the substances, known as
      inhibitors of senescence, were shown to increase the AOA in vivo. The effect of
      substances on the antioxidative activity of lipids is considered as a useful test
      for selection of agents, which appear promising as drugs for prolongation of
      survival periods.

PMID- 1027242
TI  - [Electrophoretic study of liver histones in the postnatal ontogeny of white rats:
      the effect of testosterone propionate and gonadectomy].
AB  - By means of polyacrylamide gel disc electrophoresis heterogeneity,
      electrophoretic mobility and relative content of different fractions of histones
      in nuclei of liver cells were studied in gonadectomized Wistar rats and in
      castrated in intact animals, administered with testosteone propionate. In all the
      experiments a significant conservatism of histone proteins  was found in
      postnatal development. In animals, treated with the endocrine preparations, the
      age peculiarities were shown to reflect the quanitative proportion of different
      histone fractions.

PMID- 1027243
TI  - [Possible change in the substrate specificity of the monoamine oxidase of rat
      brain and liver mitochondria in hyperoxia].
AB  - Maintenance of animals in conditions of increased oxygen pressure at 4 atm within
      1 h caused a decrease in activity of monoamine oxidase from rat brain
      mitochondria and liver tissue; at the same time, deamination of putrescine and
      AMP was increased. Deamination of glucosamine was also observed in brain
      mitochondria. The qualitative alterations in the monoamine oxidase activity were
      more distinct in brain than in liver tissue. The enzymatic activity was partially
      restored by addition of ascorbic acid to the suspension of mitchondria.

PMID- 1027244
TI  - [Factor XIII as a stimulator of thrombin activity].
AB  - The coagulating activity of thrombin was increased by 120% and the esterase
      activity--by 100% after incubation of thrombin with factor XIII. Factor XIII also
      stimulated generation of thrombin in the test of two-step estimation of
      prothrombin. The effect, arising from the interaction of factor XIII with
      thrombin, was specific for this enzyme because the esterase activity of trypsin
      was not increased during incubation of enzyme with factor XIII under the same
      conditions. The data obtained suggest that factor XIII or its fragment are
      effectors of enzymatic activity of thrombin in vitro and in vivo.

PMID- 1027245
TI  - [Method of gradient chromatography for the isolation of purified lipid fractions
      from nerve tissue in studies using radioactive carbon, C14].
AB  - A method is developed for separation of lipids from nervous tissue by thin-layer
      chromatography in silica gel. Cholesterol and "minor" lipids were removed from
      the start by the first chromatography in the system ether-benzol-ethanol-acetic
      acid. Phospholipids and galactolipids, which remained at the start, were
      separated by the repeated chromatography in the system chloroform-methanol-NH4OH.
      The purified fractions of cholesterol, cerebrosides, sulfatides and the total
      fraction of phospholipids were obtained from 100-150 mg of nervous tissue in
      amounts, sufficient for estimation of their specific radioactivity in experiments
      with 14C.

PMID- 1027246
TI  - [Nomenclature of peptide hormones. Commission of Biochemical Nomenclature of the
      International Society of Pure and Applied Chemistry and the International
      Biochemical Society. Recommendations (1974)].

PMID- 1027247
TI  - [Binding of C14-histamine by plasma membranes of cells from gastric mucosa of
      rats].
AB  - It was established that in rat gastric mucosa cells the receptor proteins capable
      of binding 14C-histamine were components of plasma membranes. Analysis (by
      Scatchard method) of curves of 14C-histamine binding by receptor proteins
      demonstrated that in plasma membranes there were two types of receptors: with
      high and low affinity to histamine. A specific histamine H2-receptor blockator-
      burimamide--inhibited competitively the binding of labelled histamine by plasma
      membranes. The data obtained suggest that the activation of adenyl cyclase by
      histamine is the result of specific binding of this amine by proteins of plasma
      membranes in rat gastric mucosa cells.

PMID- 1027248
TI  - [Delay in thrombin clearance as a diagnostic test of prethrombosis in depression
      of the anticoagulation system caused by atherogenic diet].
AB  - Decrease in 131I-thrombin clearance and decrease in absorption of complexes of
      thrombin with other substances in liver tissue were observed under conditions of
      depression of anticoagulation system found in animals maintained on altherogenic
      diet. Prolonged administration of an antisclerotic drug "Linetol" and of vitamin
      A into these animals promoted restoration of anticoagulation system. The
      restoration was tested by intensification of 131I-thrombin clearance and by
      accumulation of 131I-thrombin-heparin complex in liver tissue. Decrease in
      thrombin clearance, in combination with other tests, could be used for diagnosis
      of prethrombosis under conditions of experimental depression of anti-coagulation
      system.

PMID- 1027249
TI  - [Antivitamin activity of thiaminase from freshwater bicuspid molluscs after
      parenteral administration of the enzyme to albino mice].
AB  - Thiaminase from bicuspid mollusc, after a single administration into mice (25 or
      50 un, subcutaneously), caused a decrease in the activity of transketolase and
      alpha-ketoglutaric acid dehydrogenase in the animal tissues within 3 hrs. The
      maximal antivitaminous effect of thiaminase was manifested within 2-5 days and
      slightly decreased within 7 days (at a dose of 25 un). Amount of thiamin was
      decreased in mice liver tissue from 6.54+/-0.36 mcg/g to 4.84+/-0.23 mcg/g within
      the second day after the thiaminase administration. Transketolase and alpha
      ketoglutarate dehydrogenase from liver and kidney were more sensitive to the
      antivitaminous effect of thiaminase. General condition of the animals was not
      altered by parenteral administration of thiaminase during a week. Thiaminase may
      be recommended for modelling of thiamin deficiency in animals maintained at
      conventional diets.

PMID- 1027250
TI  - [Effect of insulin and hydrocortisone on the isoenzyme composition of pyruvate
      kinase in the rabbit kidney].
AB  - Alloxan diabetes, starvation of rabbits within one day and administration of
      hydrocortisone during 5 days did not cause distinct alterations in the total
      activity of pyruvate kinase in kidney cortex. At the same time pronounced
      alterations in the isozyme spectra were observed: the L-type activity of pyruvate
      kinase was decreased and the M2-type of activity was increased. The total
      activity and the isozyme content of pyruvate kinase were only slightly altered in
      starvation of rabbits during 3 or 10-16 days and after administration of
      protamine-Zn-insulin during 3 days. Hydrocortisone caused variable effects on the
      pyruvate kinase isozymes from kidney cortex, depending on periods of
      administration.

PMID- 1027251
TI  - [Effect of insulin of acetylation of histones and non-histone proteins in the
      cell nuclei of the liver of albine rats of different age].
AB  - After administration of insulin acetylation of histones and acid proteins in
      liver cell nuclei was decreased within 30 min; it increased gradually within 120
      min and there was no difference as compared with control within 360 min in young
      animals. Incorporation of acetate label into proteins was inhibited within 90 min
      after the hormone loading in old animals and it did not differ from control
      within 120 min. Under these conditions acetylation of globulin proteins was
      decreased within 30 min; it approached the control level within 60 min after
      which it did not distinctly alter ad compared with the control.

PMID- 1027252
TI  - [Nature of changes in the activity of certain enzymes of energy metabolism in the
      liver after partial sympathectomy].
AB  - Partial sympathectomy of rat liver, carried out by bilateral section of celiac
      nerves, caused a distinct increase in the activity of hexokinase and glucose-6
      phosphate dehydrogenase and (less distinctly) of 6-phosphogluconate dehydrogenase
      and lactate dehydrogenase in liver tissue. The alterations in glucokinase
      activity were not statistically significant. Noradrenaline disappeared completely
      from rat liver after the celiac nerves section. Activities of the above-mentioned
      enzymes were altered to the same degree in sympathectomized liver of
      adrenalectomized animals. The increase in the hexokinase and glucose-6-phosphate
      dehydrogenase activity was prevented by administration of actinomycin D
      immediately after the section of celiac nerves. The data obtained suggest that
      after section of liver celiac nerves the alterations in the enzymatic activities
      are determined by the increase of their biosynthesis and occur as a result of
      impairment of liver sympathetic innervation.

PMID- 1027253
TI  - [Effect of insulin of dehydrogenases of pentosephosphate pathway and content of
      free fatty acids in rat kidney].
AB  - After administration of insulin into rats activity of dehydrogenases of
      pentosephosphate pathway was not altered in cortex and medulla of kidney as
      distinct from the liver tissue. Concentration of free fatty acids was slightly
      lower in soluble fraction of kidney cortex than in blood plasma and higher than
      in preparation from kidney medulla. Alterations in content of free fatty acids
      were not observed in the preparations of kidney of rats with alloxan diabetes.

PMID- 1027254
TI  - [Degradation of transfer RNA from skeletal muscles of rats during autolysis].
AB  - sRNA were extracted from postmitochondrial fraction of rat sceletal muscles by
      the phenol method. Their yield, physico-chemical properties and acceptor activity
      during postmortal destruction were studied. Within 2 days after the death yield
      of sRNA was decreased by 18-20% with maintenance of the physico-chemical
      properties studied. At the same time the acceptor activity (towards 4 amino
      acids) was distinctly decreased. For various amino acids correlation between a
      decrease in the acceptor activity and the time of autolysis was different. Three
      peaks of radioactivity were observed when 14C-phenyl-alanine-sRNA was
      fractionated on DEAE-Sephadex A-25; two of them were distinctly decreased after
      24 hrs autolysis but the third one was maintained almost without alterations. The
      data obtained suggest that separate types of sRNA are degraded selectively at
      early steps of postmortal autolysis.

PMID- 1027255
TI  - [Activity of protein-synthesizing system and RNA synthesis in the liver and
      spleen of rats in stress caused by burns].
AB  - Period of decreased protein synthesis was observed in rats within first hours,
      after burns but later on the synthesis was distinctly increased in liver and
      spleen tissues. This increase was apparently due to induction of RNA synthesis as
      actinomycin D removed the effect of burns on the protein synthesis. Immediately
      after the burns incorporation of 14C-orotic acid into rapidly-lebelling RNA of
      rat liver tissue was increased; the increased RNA synthesis was observed and at
      the 3-rd day after burns.

PMID- 1027256
TI  - [Activation of the rate of enzymatic formation of sulfhydryl groups by
      serotonin].
AB  - Administration of serotonin into animals and incubation of serotonin with
      homogenates stimulated disulphide reductase in liver and spleen tissues. The
      effect of serotonin in vivo was probably mediated by liberation of
      catecholamines; it was eliminated by pyrilene and reserpine. The reflex
      mechanisms of catecholamines liberation were mediated by serotonin through
      serotonin-receptors of T-type. Alteration in the disulphide reductase activity
      correlated with the increased content of thiols after administration of
      serotonin.

PMID- 1027257
TI  - [Effect of diet with high fat content on lipogenesis in the liver, lipid
      composition and lipoprotein spectrum of blood].
AB  - Content of lipids and lipoprotein composition in blood did not reflect the
      intensity of lipogenesis in liver tissue of rats, which were kept on diets with
      high content of vegetable or animal fats. Both diets with excess of fat increased
      the rate of acetylation reaction in synthesis of glycerides and esterification of
      free cholesterol in liver tissue. In this case secretion of synthesized lipids
      into blood was decreased. Excess of vegetable oil, as distinct from animal fat,
      decreased the content of glycerides, pre-beta and beta-lipoproteins in blood and
      activated the synthesis of free cholesterol in liver tissue.

PMID- 1027258
TI  - [Effect of rimantadine on the synthesis of virus-specific RNA in the culture of
      cells infected with Sindbis virus].
AB  - Effect of rimanthadine (alpha-methyl-I-adamantane methylamine) on the synthesis
      of virus specific RNA was studied in culture of cells, infected with Syndbis
      virus. Rimanthadine inhibits the synthesis of virus specific RNA beginning from
      the 3-rd hr of infection. A magnitude of inhibition from the 3-rd to the 7-th hrs
      of infection was practically the same and exceeded 50%. In the presence of
      rimanthadine "early" RNA was formed (with sedimentation constant of 20-14 S),
      where radioactivity was lowered as compared with control; formation of more
      "late" RNA peaks (43 S, 34 S and 26 S) was completely prevented within these
      periods of infection.

PMID- 1027259
TI  - [Determination of total and inorganic phosphorus in the presence of organic
      phosphoric acid esters and proteins].
AB  - Total phosphorus was estimated after mineralization of a sample, containing
      organic phosphoesters and proteins; a method is based on the formation of
      phosphomolybdenovanadium complex at acid pH. The analyses for inorganic
      phosphorus were carried our together with estimation if some labile phosphoesters
      (glucose-I-phosphate, ADP, ATP), which was possible due to low acidity of the
      medium (0.24 N HC1O4), small concentrations of reagents (3.2 mg/ml of molybdate,
      0.08 mg/ml vanadate), addition of sodium citrate to neutralize the excess of
      molybdenovanadium acid and extraction of the colored complex with butyl or
      isobutyl alcohol. Optical density was measured at two wave lengths (340 nm and
      390 nm) which enabled to estimate from 0.5 to 80 microng of phosphrorus in a
      sample.

PMID- 1027260
TI  - [Prognostic significance of electroencephalogram indices in nursing infants with
      cerebral lesions in the perinatal period].

PMID- 1027261
TI  - [Birth injuries of the vertebral artery and their role in the pathogenesis of
      pediatric cerebral paralysis syndromes].

PMID- 1027262
TI  - [Effect of the initial level of immunity and allergy on the results of primary
      and repeated immunizations aagainst smallpox].

PMID- 1027263
TI  - [Nonspecific reactions of the nervous system in children].

PMID- 1027264
TI  - [Rational ways to optimize the diagnosis of acute appendicitis in children].

PMID- 1027265
TI  - [Peripheral blood leukocytes (form and function) (a lecture)].

PMID- 1027266
TI  - [Prognosis of labor based on anthropometric data].

PMID- 1027267
TI  - [Cervix test in the prognosis and management of labor complicated by premature
      bursting of waters].

PMID- 1027268
TI  - [Diagnosis of retention of the separated afterbirth in the uterine cavity in the
      third period of labor].

PMID- 1027269
TI  - [Giant cyst of the spleen in a child].

PMID- 1027270
TI  - [Clinical characteristics of neurasthenia in adolescents who suffered birth
      trauma].

PMID- 1027271
TI  - [Use of large doses of iron glycerophosphate in the therapy and prevention of
      allergic diseases in children].

PMID- 1027272
TI  - [Dynamics of the cortisol content in the blood plasma in specific
      hyposensibilization in children with bronchial asthma].

PMID- 1027273
TI  - [Quantitative characteristics of placental transfusion in the afterbirth stage of
      labor].

PMID- 1027274
TI  - [Glucocorticoid function of the adrenal cortex in a hypoxic lesion of the central
      nervous system in newborn infants and in those in the first months of life].

PMID- 1027275
TI  - [Antibiotic therapy of septic diseases in newborn and premature infants].

PMID- 1027276
TI  - [Problems of the rational use of antibiotics in acute penumonia in children].

PMID- 1027277
TI  - [Antibiotic therapy of protracted, recurrent and chronic pneumonia in children].

PMID- 1027278
TI  - [Principle of the universal bond between theory and practice of medicine].

PMID- 1027279
TI  - [Membrane digestion and the mechanisms of malabsorption in childhood].

PMID- 1027280
TI  - [Clinical and endoscopic comparisons in chronic gastritis in children].

PMID- 1027281
TI  - [Dependence of the gastric secretory function on the pathohistological changes in
      the mucosa of the fundic and antral portion of the stomach and duodenum in
      children].

PMID- 1027282
TI  - [Biochemical makeup of the bile in healthy children and in those with diseases of
      the biliary system].

PMID- 1027283
TI  - [Differentiated diagnosis of dyskinesia of the biliary tracts in children and the
      treatment approach].

PMID- 1027284
TI  - [Comparative studies of the intrahepatic hemodynamics in children with cirrhosis
      of the liver and chronic cardiovasculary insufficiency].

PMID- 1027285
TI  - [Hydroxyproline excretion in children with chronic liver diseases].

PMID- 1027286
TI  - [X-ray diagnosis of chronic and recurrent duodenal obstruction in children].

PMID- 1027287
TI  - [New antibiotics and some principles of the modern antibiotic therapy of
      bacterial infections].

PMID- 1027288
TI  - [Rheohisterography in late pregnancy toxicoses].

PMID- 1027289
TI  - [Treatment of habitual abortion with caprovestrol].

PMID- 1027290
TI  - [Treatment of tubal sterility with a combination of hydrotubation and ultrasonic
      massage].

PMID- 1027291
TI  - [Immunoglobulins of the cervical mucus in women with sterility of unclear
      etiology and in pregnancy].

PMID- 1027292
TI  - [Carbuncle of the kidney in children].

PMID- 1027293
TI  - Hospital study tour in Denmark.

PMID- 1027294
TI  - Medical manpower planning: the British experience.

PMID- 1027295
TI  - The role of the ombudsman in Britain.

PMID- 1027296
TI  - 8th conference on hospital services in Europe.

PMID- 1027297
TI  - [Civilization and psychiatry].

PMID- 1027298
TI  - [Malignant hyperthermia in Belgian landrace pigs].

PMID- 1027299
TI  - [Genetics of microorganisms].

PMID- 1027300
TI  - [Cytogenetics of antiviral immunity].

PMID- 1027301
TI  - [Effect of hormones on the realization of gene activity].

PMID- 1027302
TI  - [Genetics of cytoplasmic organoids and hereditary diseases in man].

PMID- 1027303
TI  - [Current problems of clinical genetics].

PMID- 1027304
TI  - [Ultrastructural study of the epithelium of the human vagina. II. Parabasal and
      intermediate stratum].

PMID- 1027305
TI  - [Ultrastructural study of the epithelium of the human vagina. III. Superficial
      stratum].

PMID- 1027306
TI  - [Treatment of pertrochanteric fractures].

PMID- 1027307
TI  - [Treatment of sub-trochanteric and diaphyseal-trochanteric fractures].

PMID- 1027308
TI  - Surgical treatment of acute injuries of the lateral ligaments of the anklejoint
      and chronical lateral ligament insufficiency.

PMID- 1027309
TI  - [Repair of the patellar tendon: modified technic].

PMID- 1027310
TI  - [Examples of arthrosic knees after miniscetomy].

PMID- 1027311
TI  - [Results of 370 upper tibial osteotomies for axial deviation fixed by an angular
      monoblock material with more than 2 years recession].

PMID- 1027312
TI  - [Insufficiency of the first ray in metatarsalgias].

PMID- 1027313
TI  - [Application of the technic of intramedullary pinning according to Hackethal for
      two-stage fractures of the humerus].

PMID- 1027314
TI  - Treatment of forty loosened total hip replacement.

PMID- 1027315
TI  - Agenesis of pancreas and gall-bladder in an infant of incest.
AB  - Fatal diabetic coma was observed in a small-for-gestational-age newborn of
      brother-sister incest. Post mortem examinations revealed congenital absence of
      the pancreas and gall-bladder.

PMID- 1027316
TI  - [Transfer factor treatment of chronic mucocutaneous candidiasis].

PMID- 1027317
TI  - Trace elements in the serum of mothers and their children.
AB  - The serum copper, zinc and iron levels, iron binding capacity and coeruloplasmin
      activity were determined in 28 maternal and cord bloods and in 50 infants and
      children. At the end of the gestation period the serum copper level increased,
      iron concentration remained unchanged while the level of zinc decreased
      significantly as compared to the values for healthy, non-pregnant women. Iron and
      zinc concentrations at birth were significantly higher in the newborn than in the
      mother, whereas the copper level amounted only to 20% of the maternal value.
      Subsequently, the copper level increased to reach the lower limit of healthy
      adults in the first to second year of life. The remarkably high neonatal zinc
      concentration fell significantly in the first 2 to 4 weeks of life and decreases
      to the normal adult level at one year of age. The changes in the trace element
      concentrations may be due to quantitative differences in the transporting
      proteins, variations in placental permeability and in the function of transfer
      proteins.

PMID- 1027318
TI  - Immunoglobulin E in the sera of infants and children.
AB  - The serum IgE level has been studied from birth up to 14 years of age. The mean
      serum IgE concentration was found to be correlated with age. Parallel
      measurements in cord blood and maternal blood yielded a mean of 25 I.U./ml
      (range, 0--90 I.U.) for the former and one of 124 I.U./ml (range, 50-600 I.U.)
      for the latter. The normal IgE level ranged from 20 to 100 I.U./ml in infants and
      from 100 to 200 I.U./ml in children, but even values of 400 to 600 I.U. did not
      necessarily reflect a pathological condition. In the majority of patients with
      eczema, urticaria and spastic bronchitis, high IgE levels were measured. The
      highest individual and mean values were obtained in children harbouring
      intestinal helminths, though a normal IgE level also occurred in such patients.
      In coeliac disease the values were within normal limits.

PMID- 1027319
TI  - [Prevention of postnatal hypothermia].

PMID- 1027320
TI  - Idiopathic respiratory distress syndrome: acoustic, laryngoscopic and
      radiological investigation.
AB  - The breathing pattern in IRDS has been analysed by sound recording, direct
      laryngoscopy and chest X-rays. The reflex mechanism operative in IRDS was found
      to be a modified version of the Hering-Breuer reflex; in a certain phase of
      inspiration the respiratory muscles relax and passive expiration begins. In IRDS,
      at the end of the short inspiratory phase accompanied by grunting the glottis is
      suddenly closed, and collapse of the alveolar space is prevented. The small
      opening of the glottis before the next inspiration serves the same purpose, and
      the air passing through it is heard as grunting. As soon as the alveolar space is
      emptied, the glottis becomes wide open and a quick inspiration follows. The
      modified Hering-Breure reflex increases the respiratory tract pressure and thus
      prevents collapse of the alveolar space. When the newborn is no longer capable of
      the excess extra work required for grunting, the decompensated phase of IRDS sets
      in. Gas exchange rapidly deteriorates and the white lung pattern is visible on
      the chest X-ray.

PMID- 1027321
TI  - Altered response in vitro of the human umbilical artery to sera of neonates with
      respiratory distress syndrome and other hypoxic conditions.
AB  - A study was made of the reaction of the human umbilical artery and the isolated
      rabbit auricular artery to protein-free ultrafiltrates of normal and hypoxic sera
      originating from neonates suffering from RDS or other acute metabolic
      disturbances. While a normal serum ultrafiltrate caused an enhanced contraction
      of the umbilical artery, hypoxic sera exerted a weaker pressor activity. At the
      same time, on the rabbit's isolated auricular artery the hypoxic sera exhibited a
      higher pressor activity. The phenomenon is in agreement with the clinical
      observation that spontaneous closure of the umbilical vessels is delayed in the
      case of fetal hypoxia.

PMID- 1027322
TI  - [Value and significance of HPL (human placental lactogen) determination in the
      course of the routine examination of healthy pregnant women].

PMID- 1027323
TI  - The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic
      small-for-gestational-age infants. I. Changes in blood glucose, blood lactate and
      plasma free fatty acids.
AB  - The response to glucagon infusion of blood glucose, blood lactate and plasma FFA
      was studied in 7 normoglycaemic and 7 hypoglycaemic SGA infants. The infants
      received glucagon at a rate of 0.2 microng/kg/min into a cephalic vein for a
      period of four hours. Glucagon caused a marked and significant rise in blood
      glucose in both groups; from 66 +/- 12 mg/100 ml to 136 +/- 16 mg/100 ml in the
      normoglycaemic, and from 22 +/- 2 mg/100 ml to 69 +/- 13 mg/100 ml in the
      hypoglycaemic infants. The time course of the response was different: while in
      the former group blood glucose declined after the second hour of glucagon
      infusion, in the hypoglycaemic group the response persisted throughout the test
      period. In the normoglycaemic SGA infants FFA fell rapidly in response to
      glucagon, whereas no significant change occurred in hypoglycaemic infants. The
      different baseline lactate concentrations were not affected significantly.

PMID- 1027324
TI  - The metabolic effects of glucagon infusion in normoglycaemic and hypoglycaemic
      small-for-gestational-age infants. II. Changes in plasma amino acids.
AB  - Altogether 17 individual amino acids were determined before and during glucagon
      infusion in normoglycaemic and hypoglycaemic SGA infants. The magnitude and time
      course of the response in total plasma amino acids to glucagon infusion (0.2
      microng/kg/min for four hours) differed in the two groups: while in the
      normoglycaemic SGA infants a significant hypoaminoacidaemia was noted by the
      second hour of glucagon infusion, in the hypoglycaemic newborns no appreciable
      changes were observed. In the former group altogether twelve amino acids showed a
      progressive and significant decline. The fall of three important gluconeogenic
      amino acids alanine, glycine,proline, and that of three branched chain amino
      acids was particularly striking. In contrast, in the hypoglycaemic infants the
      amino acids were not significantly affected by glucagon infusion. This
      unresponsiveness of plasma amino acids was probably transient as judged from the
      moderate hypoaminoacidaemia noted by the end of the infusion period. The
      observations seem to have important implications regarding the influence of
      glucagon on hepatic glucose production, and its possible therapeutic importance
      in the management of hypoglycaemic intrauterine malnourished infants.

PMID- 1027325
TI  - [Presuppositions and orientations in sex education literature. Brief report of an
      observation].
AB  - This article publishes the result of a gallup done with 40 books and publications
      dealing with sexual education and representing styles and tendencies as
      diversified as possible. The aim consisted insearching the multisciplinary
      structure (physiology, psychology, sociology, ethics...) on which the authors
      rely explicitely for proposing pedagogic orientations. It appears from analyses
      that the educational aim is most often limited to an information giving the
      greatest importance to anatomophysiological factors of reproductive functions. A
      larger concept of sexuality including dimensions of body eroticism, on the one
      hand, and psychological, social and relational ethical factors, on the other
      hand, is rejected by some authors proning pedagogic "neutrality". These
      dimensions are used in an "engaged pedagogy" by other authors, but differently
      according to their view of "sexual liberalisation" or humanistic or christian
      sexual ethics. Critical considerations are added to the description of these
      various tendencies.

PMID- 1027326
TI  - [Sexologies: discussions and desires].
AB  - The present reflexion deals with the phenomenon of sexology and more precisely
      with sexologists. The author questions the sense of concepts apparently opposed
      to a scientific sexology anthropology. The key is searched in the way of being
      sexologists, their experience of pleasure, anxiety, the power based on knowledge
      and action. Their own experience guides their concepts of social order and sexual
      (dis)order. Sexuality itself, implicating sexologists in its relational essence,
      analogous to language, carries the dialectic elements found in sexology.

PMID- 1027327
TI  - [The transsexual enigma. Apropos of the work of Jan Morris "Enigma"].
AB  - The fixity of the therapeutic demand of the transsexual renders it refractory to
      psychotherapeutic analysis, which always tries to reveal an other demand behind
      the explicit demand. But the transsexual wants nothing else than to obtain from
      the medical wf his intime conviction to belong to the opposite sex despite his
      non equivoqual hormonal anatomic and genetic sex. As a consequence, he demands
      surgical correction of this mistake of nature. The author wants to draw from J.
      Morris's remarquable work, both on human and literary grounds, the essential axis
      of the deep problems of the transsexual: the precocious apparition of the
      conviction which becomes irreversible, the concern to have it accredited by
      scientists, a desexualised verbalisation with a rich claim for gender
      (psychological sex), the impact of the desire of the mother on the future of the
      subject, the necessary idealisation of the mother (virgin cult), the problem of
      castration, the link between identity and recognition by the other. The
      psychotherapeutic failure gives rise to an important theoretical lesson which is
      clearly illustrated in the transsexual: one can not conound penis and phallus
      (Lacan), because if the transexxual is ready to live without the former, it is to
      obtain (or become) the latest.

PMID- 1027328
TI  - [Morals and sex deviations].
AB  - Deviance is today more often recognized. It questions norms or established order.
      Sociology, medicine, law, moral, even if they use the same terms, such as
      deviance or normality, deal with these realities differentialy. Being more
      conscious of it allows to define the conditions of a more true and serene
      dialogue, starting from various disciplines. One wonders more particularly on the
      specific role of moral. Must the elaboration of moral norms be done in reference
      to "normality", or do we have to look for lines of sexual humanization?

PMID- 1027329
TI  - [Psychology and fecundity. Motivations for parenthood].
AB  - Questions relating to population problems are more and more important at
      different levels, i.e. political, economic, national and international. In
      demographical research, sociological analyses were routine, but other disciplines
      such as psychology have rarely been emphasized for understanding mechanisms of
      fecondity. In a preliminary research on motivations to parenthood, this article
      proposes a critical analysis of the main orientations of research in the area of
      fecondity: socio-psychological studies, analytical and other works
      psychologically oriented on attitudes, motivations and values towards the child.
      It also delines the conceptual frame for a new research.

PMID- 1027330
TI  - Keratoconus and hydrophilic contact lenses.

PMID- 1027331
TI  - Cervical spinal cord injuries in Czechoslovakia 1973 - 1974.

PMID- 1027332
TI  - Clinical study of status epilepticus; review of 111 statuses.

PMID- 1027333
TI  - Heterotopic contralateral projections of neocortical regions of the cat brain.
      II. Parietal cortex. A. Interhemispheric association of parietal cortex.

PMID- 1027334
TI  - Pathophysiological classification of anaemias and polycythaemias (polyglobulias).

PMID- 1027335
TI  - Heterotopic contralateral projections of neocortical regions of the cat brain.
      II. Parietal cortex. B. Laminar distribution of interhemispheric association
      fibres in the cat neocortex.

PMID- 1027336
TI  - Changes of muscle fibre thickness following diets of various types and
      administration of drugs in experimental animals.

PMID- 1027337
TI  - Changes in thickness of muscle fibers in "compensatory" hypertrophy of skeletal
      muscles.

PMID- 1027338
TI  - The importance of hygienic practices during the collection and bottling of
      mineral water.
AB  - Natural water suitable for direct bottling must be clear, colourless, and free
      from objectionable taste and odour. The mineral content must be limited in
      amount, otherwise the water would come within the medicinal water category. There
      should be no detectable organic matter present and the water must be of the
      highest bacteriological quality -- virtually sterile - and should remain in this
      condition during the collection and bottling processes. In order to achieve and
      maintain this high quality, the gathering grounds of the source must be protected
      from pollution; the construction of the well or spring must be such as to prevent
      external contamination, as also should be the collecting and bottling apparatus.
      Personnel employed in the factory should wear protective clothing and be
      regularly checked as to their freedom from waterborne infectious diseases.
      Control of the water as to its hygienic quality should be by regular and frequent
      analysis of samples of the water and the air at various points in the process and
      in the factory. A new problem that has arisen and has to be faced in this
      situation is the risk of contamination by certain materials in contact with the
      water that may contain substances that encourage the growth of saprophytic
      bacteria which would contaminate by the production of taste, odour,
      discolouration, cloudiness and definite evidence of microbial growth. It is
      emphasized that the extent of this new problem is not yet delineated and that
      methods of laboratory control and safeguards against such happenings are still
      evolving.

PMID- 1027339
TI  - La signification du nombre et de la nature des microorganismes telluriques
      presents dans l'eau minerale a l'emergence.
AB  - Water of the best protected mineral sources always contains a small number (often
      less than 10/ml) of "authochtonous" bacteria which multiply and subsist
      infinitely in the underground sheets. These bacteria are psychrotrophic, able to
      multiply in the absence of detectable traces of organic matter, but grow better
      in the presence of organic matter. They are very sensitive to the antiseptic
      agents currently used to purify drinking water. For reasons that are still
      unknown, these bacteria rapidly multiply in bottled water. However, this
      multiplication never leads to appearance of a sufficiently great number of
      populations to affect the limpidity of the water. It has been demonstrated that
      these autochtonous bacteria are not able to become established., i.e. to multiply
      and subsist in a great number in the digestive tract of axenic mice receiving
      mineral water. The conclusion of this is that there are no risks for
      multiplication of this bacteria in the organism of the consumer. The absolute
      number of these bacteria in bottled water has therefore no sanitary significance
      for the consumer and it seems not to be justified to establish strandard
      recommendations with respect to this. In the water sheet, only an abrupt rise in
      the number of autochtonous bacteria beyond the usual level, which varies much
      according to sheets, represents an unfavourable indication. Indeed, this might
      correspond to an accidental infiltration of organic matter and consequently of
      pathogenic bacteria into the water sheet. Search for bacteria as indicators of
      fecal pollutions therefore remains the most reliable method for estimating the
      hygienic quality of mineral water or of any other food products.

PMID- 1027340
TI  - [Comparative studies on the course of microbial flora in natural mineral waters
      bottled in glass, PVC and laminated polyethylene].
AB  - The Authors report the results of comparative investigations carried out on some
      mineral waters bottled in various containers (laminated polyethylene, glass,
      PVC). The microbic charges vary in relation to the kind of container and resulted
      to be lower in the case of containers made of polyethylene.

PMID- 1027341
TI  - [Legal aspects of mineral waters].
AB  - The Author takes up the subject of the report in order to carry out a
      comprehensive legal recognition of the mineral water regulations in Italy and
      emphasizes that in this field the results of scientific conclusions, or rather of
      the various scientific branches (medical hydrology, microbiology, chemics,
      hydrogeology, medical clinics, pharmacology, etc.) supply a cognitive support to
      the legislator and the substantial contents to the legal standards. He therefore
      illustrates the two main outlines of the rules, i.e. the hygienic sanitary one
      and the mineral one: such lay-out is subsequently related to the implementation
      of the Regions on one hand and to the enforcement of CEE-rules on the other. This
      has led to the fact that the hygienic-sanitary legislation was confirmed to the
      State while the mineral one was transferred to the Regions. After having shown up
      contrasts and expressed the necessity of clearness and uniformity of rules and
      criteria, the Author connects these requirements mainly with the implementation
      of hygienic-sanitary surveillance and consequently with the evaluation of the
      banal bacterical contents under the point of view of merit--i.e. the rules should
      include the probative results of science--as well as from a point of view of
      coordinated allotments of competence by the various organisms.

PMID- 1027342
TI  - [Considerations on critics towards conditioned waters (drinking water in general
      and particularly mineral water) especially from the microbiological point of
      view].
AB  - After having precised what has incited to extend our considerations reported at
      the International Congress on Microbiology for Mineral Waters to all the
      conditioned waters, in a "first part" we have examined the drawbacks imputed to
      the water itself. a) In a first analytical chapter, we have made the schedule and
      the critical examination of the different reproaches given to conditioned waters
      on considering successively: 1) Special drawbacks (although these are of an other
      category than microbiology) which were given, whichever type of supply (loose, at
      the tap, or splitted up when the water is conditioned), to some categories of
      waters (carbonated and mineral) because of their nature by the fact that these
      waters do not show the charactheristics of potability with regard to the
      legislation and administration. This examination leads to eliminate those
      reproaches because the consumer knows to which he is exposed, being forewarned: 
      when he is using mineral water at the cure-resort, by the thermal consultant who
      is watching over him, -when he is using one or the other of the conditioned
      waters, -either by the medical practictioner, who should give him the contre
      indicates; -either by indicating on the label, if not the contre-indicates (like
      we would hope that they figure on), at least the composition (which now figures
      within the EEC).

PMID- 1027343
TI  - [Problems in the interpretation of hygienic indices of mineral waters in the
      light of current standards].
AB  - After several references to the Italian laws now in force in this field, the
      Author emphasizes the necessity of bringing them up to date both from an
      analytical and from an explanatory point of view. In particular, he calls
      attention to the difficulties to be encountered in establishing regulations in
      view of the presence of saprophytes in natural waters.

PMID- 1027344
TI  - [Evaluation of diabetic glycemic control in hospital and extra-hospital regimen
      (author's transl)].
AB  - It is suggested an evaluation of the degree of diabetic control in insulin
      dependent "difficult" patient, during the period following the discharge from
      hospital. In 13 cases, the quality of glycemic regulation was compared in intra-
      and extra-hospital therapeutic regimen by means of 3 new indices of the diurnal
      blood sugar profile: the Mbs, delta, and Mdelta values. Mbs value describescribes
      the mean level of the blood sugar curve; delta indicates the amplitidue of the
      glycemic variability field; Mdelta reports both maximal and minimal extremes of
      the curve. A combination of the first two parameters proved adequate for a
      clinical assessment of diabetic control. In the majority of the cases, blood
      glucose patterns were found similar or even improve in extra-hospital conditions.
      The insulin dosage ordered during hospital staying was confirmed in all, but one,
      patients. Psychological approach is probably essential for such good results. The
      procedure seems to be suitable in order to establish a more correct starting
      point for an effective treatment of the diabetic out-patient.

PMID- 1027345
TI  - [A case of ascites: cured in 1837 with 45 paracentases].

PMID- 1027346
TI  - [Sacrococcygeal teratoma. Description of 2 cases].

PMID- 1027347
TI  - [Recent acquisltions on the intercurrent relations between hormonal environment
      and cancer cells of the breast].

PMID- 1027348
TI  - [Role of the thyroid and parathyroid glands in pregnant and non-pregnant women].

PMID- 1027349
TI  - [Long-term clinical results with monocomponent insulin (MC lente) in infantile
      and juvenile diabetes].
AB  - The clinical role of insulin-antibody formation, with reference to the
      monocomponent insulin treatment (MC), is discussed in a series of diabetological
      conditions. On the basis of a five-year-experience, personal results with a MC
      Lente treatment are presented in 32 cases of juvenile diabetes subdivided as
      follows: 3 cases with insulin allergy, 5 cases with insulin lipoatrophy, 13 cases
      with high insulin requirement, 4 cases with brittle diabetes, 7 cases with
      diabetic microangiopathy (retinal and, or renal). The circulating antibody level
      was estimated by IgG-Insulin-Binding Capacity (IB), according to Christiansen.
      After transfer from conventional to MC insulin treatment it was observed: --
      disappearance of allergy and total remission of lipoatrophy, in parallel with a
      reduction of IB titer; -- decrease in insulin requirement and stabilisation of
      labile diabetic control, not always in concomitance with IB reduction; --
      deterioration of advanced diabetic retinopathy and, or nephropathy in spite of IB
      reduction. It is concluded that MC insulin constitutes a major tool in the
      treatment of the above mentioned diabetic conditions, except for advanced
      microangiopathy. Thus a MC insulin treatment should be started, as a rule, in
      newly diagnosed diabetics, to possibly prevent such complications. However
      further development of insulin purification techniques, with removal of residual
      pro-insulin antigenic sites, is to be considered.

PMID- 1027350
TI  - [Dynamic telethermography in E.N.T. cancerology].
AB  - Thermography is used in human pathology to capture and visualise infra-red rays
      emitted directly and spontaneously by the human body. The author first describes
      the main techniques of thermography, their indications their advantages and their
      potential problems:--contact thermography;--static thermography; --dynamic
      telethermography. The information provided by the latter in the case of E.N.T.
      and cervico-facial malignancies should be interpreted with caution and only as a
      complement to other investigations such as radiography, echography and isotope
      studies. The following features are seen: --the low value of cerevical
      hyperthermia in relation to lymphadenopathies, due to the "thermal interference"
      of the great vessels of the neck; --the contrast between large lymphadenopathies
      which are often quite cold in comparison with small lymphadenopathies which are
      always hot; --the value of the method in determining extension of a skin tumour,
      for the surveillance of areas already tready by surgery or physical agents, in
      seeking and discovering an endo-cavitray neoplastic zone or a bone metastasis.

PMID- 1027351
TI  - [Benign osteoblastoma. Apropos of a case localized in the upper maxilla].
AB  - Benign osteoblastoma is a benign bone tumour identified fairly recently. The
      names of Jaffe and Lichtenstein are associated with published work. Localisation
      in the maxillary sinus, as in the case presented here, is quite rare. Clinical
      examination reveals the presence of the tumour but gives no precise indication as
      to its nature. X-ray documents favourised its benign nature. Only histological
      study precisely determines the diagnosis, definitely eliminating the possibility
      of malignancy and, finally, differentiating benign osteoblastoma from other
      benign bone tumours. Treatment is purely surgical.

PMID- 1027352
TI  - [Impedancemetry. Clinical applications].
AB  - The authors call attention to the importance of the data provided by
      impendancemetry, both in its classified applications, by tympanogram, and in
      impedance-audiometry, by the study of elicited stapedius reflex. They warn
      against the tendency to consider impedancemetry as a synonym for examination in
      conductive deafness and to reserve impedance-audiometry exclusively for
      perceptive deafness. These two techniques must be coupled and their multiple
      clinical applications are very often intricated. Tympanograms based in their
      clinic on the study of relative impedance, provide equally interesting diagnostic
      data in post-otorrhea states with open eardrum as well as closed eardrum for
      which until now tympanogram was the classic test. Of course tubal disfunctions,
      serous effusions of the middle-ear, fibro-adhesive otitis and ossicles
      disruptions are part of the current diagnosis clarified by impedancemetry in
      conductive deafness. On the other hand, for otospongiosis, the tympanogram is not
      of absolute value, but impedancemetry permits an extremely interesting diagnosis
      in three cases: in associated syndroms, where it acts as warning before the
      operation; in airbone gap reopenings after surgery, where the knowledge of the
      precise etiology conditions the therapy;-- and in postoperative cochlear drops,
      where an easy differential diagnosis is allowed between perilymph fistula and
      labyrinthe hydrops. Impedance-audiometry is based on the elicitation of stapedius
      reflex. It has numerous applications in perceptive deafness, where the detection
      of recruitment is very easy and of great value. So the diagnosis between cochlear
      and retro-cochlear deafness may be made evident. This method also applies to
      conductive deafness, to crura ruptures, as well as to the diagnosis of the
      beginning of otospongiotic stapedial fixations by the detection of a typical on
      off effect. Besides otospongiosis is one of the most paradoxical applications of
      impedance-audiometry, which is revealed to be richer in information than the
      study of compliance, masking problems, diagnosis of associated syndroms and early
      detection of the disease are easily solved by impedance-audiometry. For these
      many reasons, the authors insist once more upon the importance and value of the
      data provided by impedancemetry and impedance-audiometry. They specify that this
      method is the most interesting complement to classic audiometry since the
      appearance of the audiometer.

PMID- 1027353
TI  - [Voluminous neurinoma of 2d and 3d portion of the intrapetrosal facial nerve with
      subtympanal extension].
AB  - A patient presented with a facial nerve neurinoma of unusual size and which gave
      particularly clear radiological images. The curious feature of this observation
      is that there was no pre-operative facial paralysis as happens in about 15 p. 100
      of cases.

PMID- 1027354
TI  - [Perforation of the nasal septum caused by leishmaniasis].
AB  - The perforation of the nasal septum with the crusted ulcer surrounding
      accompanied by the erythema of skin of the vestibule should suggest the
      possibility of leishmaniosis. The microscopic examination and culture of the
      secretions in N.N.N. culture medium provides confirmation of the diagnosis and
      the specific treatment could then be instituted.

PMID- 1027355
TI  - [2 cases of parapharyngeal tumors].

PMID- 1027356
TI  - [Nasal mucosa and the environment].

PMID- 1027357
TI  - [Otorhinolaryngologic manifestations of atrophying chronic polychondritis].

PMID- 1027358
TI  - [Cancer of the intermaxillary commissure].

PMID- 1027359
TI  - [Alfathesin anesthesia: its use in otorhinolaryngology].

PMID- 1027360
TI  - [Search for the recurrent right nerve in thyroid surgery of the base of the
      neck].

PMID- 1027361
TI  - [New surgical technics in atrophic rhinitis;].

PMID- 1027362
TI  - Survival of hydatid cysts after puncturing.
AB  - The release of antigens from hydatid cysts, essential for the induction of a
      detectable host antibody response, is considered to depend on alterations in the
      physical integrity of the cyst germinal membrane. This explanation, however, does
      not account for the detection of serologic responses in persons harbouring
      hyaline cysts unless it were possible for membrane microfissures to arise and
      provide an antigenic stimulus without adversely affecting cyst viability. The
      results of the present study have demonstrated that hydatid cysts are able to
      survive when experimentally punctured in vitro or in vivo. These findings on the
      capacity of hyaline cysts to repair or recuperate from a microfissure are
      consistent with the detection of antibody responses in persons harbouring hyaline
      hydatid cysts with apparently intact membranes and with the hypothesis of an
      association between integrity of cyst membranes and degree of host immunological
      responses.

PMID- 1027363
TI  - [Role of hypocorticosteronemy in the self cure mechanism in rats with
      Strongyloides ratti parasites (author's transl)].
AB  - Repeated injections of corticosterone acetate, physiological hormone of the Rat,
      in rats carrying Strongyloides ratti, oppose the deparasiting which normally
      takes place spontaneously. The secretion induced by this hormone by impregnating
      the organism through the corticotropic factor administered in the form of
      tetracosactide-zinc, achieves the same result. During all these treatments, an
      important hypercorticosteronemy is established. Stopping the injections is
      quickly followed by the worms-being rejected and the corticosteronemy returning
      to normal. The relations between the corticosteronemy and the parasitism are
      analysed and lead to the conclusion that the parasite induces an aspecific
      hypocorticosteronemiant reaction which, through its aspecific and specific
      repercussions, participates in the self-cure phenomenon.

PMID- 1027364
TI  - [Sergentomyia trouilleti (Diptera, Phlebotomidae), new species from the Congo
      (author's transl)].
AB  - Sergentomyia trouilleti, (Diptera, Phlebotomidae), new species collected in the
      north of the People's Republic of Congo is described from three female specimens.
      This sandfly is clearly differenciated from other species of the genus
      Sergentomyia by the morphology of the pharynx and the cibarium.

PMID- 1027365
TI  - Reproduction of the cycle of coccidia Eimeria acervulina (Tyzzer, 1929) in cell
      cultures of chicken kidneys.
AB  - The cycle of Eimeria acervulina was grown in primary culture of cells of three
      week-old-chicken kidneys. EHT medium (Eagle, Hydrolysate of Lactalbumine, Bacto
      Tryptose phosphate) allowed the development of this coccidium. 44 hours after
      infestation of the cells with sporozoites, the first schizonts appeared. The
      merozoites of first generation were released after 54 hours. They invaded the
      neighbouring cells and developed in them into schizonts of second generation
      mature after 68 hours. After 72 and 93 hours, a third and a fourth generation of
      schizonts were noticed. Merozoites IV create the Gamogony. To obtain the gamogony
      in vitro, we inoculated the cultures with merozoites IV recovered from axenic
      animals. The oocysts were released into the medium 45 hours after inoculation.

PMID- 1027366
TI  - Blood reference values in the lamb (Na, K, Ca, P, Mg, Cu, Zn, Cl, urea, total
      proteins, creatinine, uric acid, alkaline phosphatase, aspartate amino
      transferase, cholesterol and hemoglobin).
AB  - We have determined sixteen blood chemical parameters in three month-old lambs and
      eleven in one and a half-month old ones. We have found that three of them were
      not affected by age: potassium, copper and proteins; seven were lowered: sodium,
      calcium, zinc, chlorine, inorganic phosphate, urea and cholesterol; one was
      enhanced : magnesium. These reference values will be used as a basis for further
      controls of the flocks.

PMID- 1027367
TI  - [Diphtheria in Belgium. 1975].

PMID- 1027368
TI  - [The effect of alcohol and blood alcohol content].

PMID- 1027369
TI  - [Professional education in rehabilitation sciences and use of leisure time.
      Aspects of therapeutic recreation services].

PMID- 1027370
TI  - [The dermal elastic tissue during chronic bronchial and lung disease in children
      (author's transl)].

PMID- 1027371
TI  - [Infantile calcifying arteriopathy, review of the literature and report of one
      case (author's transl)].

PMID- 1027372
TI  - [Effects of injection of lysosome lysate into the palatine mucosa in the golden
      hamster (author's transl)].

PMID- 1027373
TI  - [Adenoacanthoma of the endometrium with extensive cellular mummification.
      Histological, histochemical and ultrastructural study].

PMID- 1027374
TI  - [Histologic diagnosis of large-form histoplasmosis. Apropos of 2 cases].

PMID- 1027375
TI  - [Bronchial elastoma].

PMID- 1027376
TI  - [Melanoblasts in the esophageal mucosa and their relationship to malignant
      melanoma].

PMID- 1027377
TI  - [Intrapulmonary hamartoma of unsual structure].

PMID- 1027378
TI  - [Pneumoconiosis in welders].

PMID- 1027379
TI  - Histochemical observations on the corpus luteum atreticum of the human
      postmenopausal ovary with reference to steroid hormone synthesis.

PMID- 1027380
TI  - [Ultrastructural aspects of the renal corpuscle during development and involution
      of the mesonephros. Study on the chick embryo].

PMID- 1027381
TI  - [Effects of thyroxine on the glossopharyngeal-vagal ganglionic complex of the
      urodelan amphibian (Triturus cristatus carnifex Laur].

PMID- 1027382
TI  - [Structure and ultrastructure of the interrenal gland of the lizard (Lacerta s.
      sicula, Raf.) in normal spring specimen and after administration of reserpine and
      estrogenic hormones].

PMID- 1027383
TI  - [Presence of mast cells in the human thyroid gland].

PMID- 1027384
TI  - [Submicroscopic organization of the cerebellum in Lacerta viridis].

PMID- 1027385
TI  - [Contribution of multivariate analysis to the functional study of bronchial
      obstruction].

PMID- 1027386
TI  - [Bronchial asthma and experimental evaluation of the antibronchospastic action of
      adrenaline, atropine and papaverine alone and in combinations].

PMID- 1027387
TI  - [Massive opacity of the right hemithorax of supposed neoplastic origin].

PMID- 1027388
TI  - [Clinical and biological gastroenterology].

PMID- 1027389
TI  - [Importance of duodenoscopy for the diagnosis of ampullary carcinoma (author's
      transl)].

PMID- 1027390
TI  - [Carbonic anhydrase inhibitors in the treatment of gastric and duodenal ulcers
      (author's transl)].

PMID- 1027391
TI  - [Malacoplasia of the cystic duct (author's transl)].

PMID- 1027392
TI  - [Mathematical analysis of myelin structure of nerves of the brachial plexus in
      antenatal and early postnatal ontogenesis of man].
AB  - A gradual increase of the information entropy indices and a decrease of the
      excess percentage is observed in the course of antenatal and early postnatal
      ontogenesis of man. The indices of the information entropy reach their maximum
      and the excess percentage reaches its minimum in children younger than 3 years.
      At that time the myelinated fibres have the most various diameters. In the
      antenatal development of man the prevalence of fine (1--4 mkm) myelinated fibres
      makes the structure of the humeral plexus nerves more definite while in the
      postnatal ontogenesis their structure is less definite since the myelinated
      fibres of different diameter are met with almost the same probability.

PMID- 1027393
TI  - [Study of various morphological structures of human cerebral cortex by
      application on the information theory].
AB  - The investigation was undertaken to determine the quantitative estimation of the
      degree of vertical organization of the III layer pyramidal neurons of areas 41,
      22, 17 and 18 of the human cortex auditory and visual analyzers by information
      methods. A brief description of the used methods of getting the evaluation (the
      index of organization -- Org) has been given. It has been shown that the
      suggested estimation in invariant with regard to the individual changes of the
      human brain parameters. It has been established that the projection-associative
      areas of the analyzers have a higher index of organization than projection areas.
      In making the interanalyzor comparison the index of organization of the visual
      areas has been found to be higher than that of the auditory areas.

PMID- 1027394
TI  - [Embryonic histogenesis of the atrioventricular segment of the heart conduction
      system of swine (Sus porcus L.)].
AB  - Histological, histochemical and neurochemical methods were used in order to study
      the features of the histogenesis of structures of the atrioventricular area of
      the conducting system of the heart and the formation of their cholinergic
      innervation in the postnatal period of the hog. Under study were 175 hearts of
      embryos of the hog at the age of 3, 4, 5, 6, 8, 10, 12, 14 and 15 weeks and 22
      hearts of adult hogs. The formation of different areas of this system was shown
      to be asynchronous. The atrioventricular fascicle is formed during the 4th week,
      the atrioventricular node -- during the 6th week and the conducting muscle fibres
      -during the 8th week of embryogenesis. The fascicle and the node have a
      complicated structure and different cellular composition. In the process of
      prenatal ontogenesis the increased amount of glycogen and increased activity of
      phosphorylase were noted in the cytoplasm of myocytes of the atrioventricular
      area of the conducting system of the heart. The cholinergic nerve fibres grow up
      to the structures of the atrioventricular area of the conducting system of the
      heart during the 6th week of embryogenesis, and by the end of the prenatal
      development they form a thick network in all its structures.

PMID- 1027395
TI  - [Fluorescence and electron-microscopic analysis of differentiation of the
      myocytes of the ventricles and atria of the avaian heart in ontogenesis].
AB  - The histogenesis of the ventricle and atria myocardium was studied in 240 chick
      embryos of from 30--34 hours up to 20 days of incubation and in 66 chickens at
      the age of 1--90 days. Fixators were the Bouin's Carnoy's and Newkomer's fluids
      and the 100% solution of neutral formalin. The paraffin sections were stained by
      histological and histochemical methods. RNA, DNA, glycogen and lipids were
      detected. The ultrafine sections of the material fixed in 1% buffer solution of
      osmium tetroxide (pH 7,2) and embedded in araldite were prepared for electron
      microscopy. The contrasting was made in solutions of acetic uranium and lead
      citrate. Electron microscope--UEMB-100K, accelarating voltage--75 kV. The
      prefunctional period of cardiogenesis is characterized by most intensive
      processes of specific differentiation of cardiac myocytes and by accumulation of
      energetic material. With the growing functional activity of the tubular heart the
      amount and size of lipid drops in the cytoplasm of differentiating cardiomyocytes
      diminished suggesting the use of lipids as the main source of energy. In the
      period of formation of the heart the trabecular myocardium of ventricles and the
      atria myocardium, seeming to perform the main functional load, are characterized
      by a better developed contracting apparatus and a considerable content of
      glycogen granules. A sharp decrease of the glycogen content at the end of the
      embryonic period is likely to be due to growing hypoxia, the appearance of lung
      respiration and transition to the other type of energy metabolism.

PMID- 1027396
TI  - [Changes in the lymphoid tissue and in the level of corticosteroids in
      staphylococcal intoxication and infection].
AB  - A complex quantitative study of changes of proliferative processes in lymphatic
      vessels on the one hand and changes of the level of corticosteroids in the
      peripheral blood in staphylococcal intoxication and infection in the same rats on
      the other hand has been carried out. In the work H3-thymidine has been used. The
      comparison of the obtained morphological data with the dynamics of the change in
      the corticosteroid level shows that the decay of lymphocytes, the devastating of
      light centers and the cortical substance of lymph nodes, an abrupt lowering of
      the amount of DNA-synthesizing and mitotically dividing cells take place in the
      period associated with a release of a great amount of corticosteroids into the
      blood. The drop of their level to control values goes in parallel with increasing
      the amount of DNA-synthesizing and mitotically dividing cells. The obtained data
      suggest that the leading role in those changes of the lympoid tissue which had
      been described by a number of authors in infectional processes is played by
      corticosteroids.

PMID- 1027397
TI  - [Adaptive characteristics of growth of human embryos and fetuses during the
      intrauterine life].
AB  - Under observations was the dynamics of growth of human embryos and fetuses in
      embryogenesis which is directly dependent on the month of the intrauterine life.
      Coefficients of correlation and regression were calculated and with their help
      the average growth of the general length of fetuses in each month of prenancy was
      determined. The enlargement of the fetus length was found to be more intensive in
      the embryonic and prefetal periods.

PMID- 1027398
TI  - [Ultrastructure of heart synapses].
AB  - The nerve endings in the intramural ganglia of the rat's heart are connected by
      synaptic and non-synaptic junctions with the dendrites and neuron bodies. Peri
      membrane indurations of synaptic complexes may look relatively symmetrical or
      asymmetrical depending on the orientation of the section in relation to the
      elements of the Akert's presynaptic lattice. In non-synaptic junctions the
      indurations are symmetrical, but the presynaptic one may be more complicated in
      its structure. The synaptic complexes are disposed in the field of synaptic
      dilatations of axons and in the sites of interlacing thin "preterminal" parts of
      axons with dendrites. They connect preganglionic fibres with dendrites, neuron
      bodies and with the filamentous and fungiform thorns.

PMID- 1027399
TI  - [Chromosomes of interphase nuclei].

PMID- 1027400
TI  - [Causes of rupture of formalinized xenovalves in the post-transplantation
      period].
AB  - The article discusses results of the morphological study of xenografts of the
      pig's valves fixed in 0.32% and 4% solution of formaldehyde which remained in the
      human heart during the period ranging from 21 months to several hours. In the
      xenovalves there occurred progressive destructive changes in their connective
      tissue basis, which led to weakening of the mechanical strength and to rupture of
      the cusps. In the majority of cases, no morphological signs of immune or
      nonspecific inflammatory cellular reaction were observed. The authors hold that
      polycondensation of protein molecules occurring in the course of preservation
      under the effect of formaldehyde, and formation of "superstrong" structures at
      the expense of increased number of transversal connections between collagenous
      fibres not always could ensure sufficient mechanical strength of the cusps of the
      graft.

PMID- 1027401
TI  - [Destruction of the aortic allo- and xenovalves of the heart depending on their
      position and time of transplantation].
AB  - The aortic valve, as well as the other valves of the heart, has a cellular
      structure. Collagenous fibres form the skeleton of the cellular structures, and
      the plexus of thinner fibres--the "walls". At early periods following the
      implantation destruction of thin fibres distributed along the periphery of the
      alveolus takes place. In the course of prolonged functioning of the allo- and
      xenovalves in a mitral position the large collagenous fibres collapse,
      defibration thereof develops and slits-vacuums and "cysts" are formed. In the
      valves which functioned for a long time in the tricuspid position no considerable
      destructive changes in the connective-tissue carcass take place.

PMID- 1027402
TI  - [Change in the ultrastructure of the muscles in thyrotoxic periodic paralysis].
AB  - The article presents data on the clinico-morphological study of three patients
      suffering from thyrotoxicosis with attacks of periodic paralysis. The muscles
      obtained by biopsy in two patients at the moment of attack and in one patient--in
      the absence of attack were investigated by the electron microscopy method. The
      data obtained make it possible to assume that in the thyrotoxic periodic
      paralysis the action of the thyroid hormones causes not only impairment of the
      mineral metabolism, but brings about changes in the structure of the membranes of
      the sarcolemma and T-system, which leads to disturbances of conductance of action
      potential into the fibre. These changes affect the function of the end cisterns
      and lead to distorsion of the processes of conjugation of excitation-contraction
      with resulting development of paresis and paralysis of muscles. Moreover, during
      the attack there take place secondary disturbances of carbohydrate metabolism,
      which aggravates the pathological process.

PMID- 1027403
TI  - [Diagnostic analysis of biogenic amines in tumors].
AB  - The modifield Falck's fluorescence-microscope method was used to investigate the
      content of biogenic amines in 218 bioptic specimens taken from patients suffering
      from tumours and other pathological conditions. It was established that
      malignanat tumours were characterized by accumulation in the tissue of the tumour
      and particularly in the reactive zone, of considerable amounts of substances with
      green luminescence (histamine, catecholamines, and probably, di- and polyamines)
      and by the disappearance of serotonin from the connective-tissue cells. In benign
      tumours, as well as in focal processes of non-tumour character (chronic gastric
      ulcer, mastitis, pulmonary tuberculosis) in the reactive zone there were always
      an increased number of connective-tissue cells containing serotonin. An opinion
      was put forward to the effect that one can judge about a degree of lesion of the
      connective tissue and the nature of the course of a pathological process from the
      character of biogenic amine contained in the elements of the connective tissue in
      the reactive zone. Identification of biogenic amines in the tissue of the
      reactive zone may serve as an additional test in carrying out differential
      diagnosis and will be of use in differentiating malignant tumours from benign
      processes and other focla pathology of non-tumour nature.

PMID- 1027404
TI  - [Autoradiographic study of cancer of the rectum before and after radiotherapy].
AB  - Prolifirative activity of rectum cancer cells was investigated with the help of
      3H-thymidine in 13 patents before and after radiotherapy in doses 2000-4000 rad.
      It was established that index of the label depended upon the degree of
      differentiation of a tumour and was in the range of 10.3 to 21%. Preoperative
      irradiation in a dose of 2000 rad caused a slight decrease in the label index
      (8.7-19%), but affected markedly the intensity of inclusion of the preparation.
      Radiotherapy in a dose of 4000 rad brought about a well pronounced reduction in
      the label index (3.1%) and in the intensity of labelling.

PMID- 1027405
TI  - [Cellular contacts and "cytoplasmic bridges" in the inflammation focus (scanning
      and transmission electron microscopic study)].
AB  - Contacts between cells in an inflammation focus were studied by the methods of
      scanning (raster) and transmission electron microscopy on a model of aseptic
      inflammation in the subcutaneous connective tissue in rats. It is shown that
      contacts among the cells of the connective tissue and the blood in the form of
      "cytoplasmatic bridges", observed in the scanning electron microscope, were not
      confirmed by the studies in the transmission microscope. The investigation of the
      "cytoplasmatic bridges" in the transmission  electron microscope revealed a close
      adjacence of the cytolemma of the contacting cells, or a harrow space between
      them as wide as 10-30 micron.

PMID- 1027406
TI  - [Diffuse polyposis of the large intestine complicated by amyloidosis of the
      internal organs].
AB  - Polyposis of the large intestine is a common affliction of the intestine which
      usually occurs as a result of inflammatory diseases or of dysplasia of embryonic
      anlages. Malignization of diffuse polyposis is observed in 70-100% of cases. A
      case of diffuse polyposis of the large intestine with initial phenomena of
      malignization in a male patient aged 44 years is described. The case in question
      was characterized by the presence of accompanying diffuse amyloidosis of a number
      of internal organs (kidney, spleen, pancreas). The onset of amyloidosis in this
      case was associated apparently with the character of absorption by a
      pathologically changed surface of the large intestine mucosa and with the
      enlargement of the surface of absorption of products of the protein metabolism.

PMID- 1027407
TI  - [Atypical form of hemochromatosis].
AB  - A rare case of an atypical course of hemochromatosis in a woman at the age of 25
      years is described; it was characterized by predominant lesions of the cardiac
      muscle, liver, pancreas, by phenomena of cardiovascular incompetence, by the
      absence of signs of melanodermia.

PMID- 1027408
TI  - Alterations in lipid metabolism produced by ethyl trichloracetate.
AB  - Rats maintained on a choline deficient diet and treated with subcutaneous doses
      of ethyl trichloracetate responded by increasing plasma beta-lipoprotein and
      plasma triglyceride levels while excess triglyceride was being removed from the
      liver. There was a transient depression in plasma phospholipid at the beginning
      of the treatment. Continued administration of ethyl trichloracetate raised plasma
      triglyceride in choline depleted rats and raised hepatic phospholipid
      concentration in both choline deficient and supplemented rats. It is suggested
      that the lipotropic action of ethyl trichloracetate occurs through hepatic
      triglyceride being removed by the altered plasma lipids and not by inhibition of
      hepatic triglyceride synthesis.

PMID- 1027409
TI  - Hepatic vitamin A fat-storage cells and the metabolism of chylomicron
      cholesterol.
AB  - These experiments were designed to test the hypothesis that the vitamin A fat
      storage cell removes chylomicron remnant cholesterol from hepatic portal venous
      blood; A modified Ficoll density gradient ultracentrifugation procedure was used
      to isolate from rat liver cellular fractions that were enriched in vitamin A. In
      rats fed a normal diet and in rats fed excess vitamin A isolated hepatocytes were
      fractionated 15 min after the intravenous injection of chylomicrons labelled in
      vivo with radioactive cholesterol. The results showed that cholesterol
      radioactivity was not concentrated in the vitamin A enriched cellular fractions,
      so it was concluded that the vitamin A fat-storage cell is not implicated in
      clearance of chylomicron remnants by the liver.

PMID- 1027410
TI  - The origin and significance of macrophages in thoracic duct lymph.
AB  - Efferent lymph collected from a thoracic duct fistula initially contains no
      macrophages. However, the surgical procedures used to insert plastic cannulae
      into efferent lymphatics incite a vigorous foreign body reaction leading to the
      contamination of collected lymph with significant numbers of these cells. A
      sensitive and specific assay for the presence of macrophages in lymphocyte
      populations was used to quantitate the degree of contamination in rats bearing
      thoracic duct cannulae. The origin of some of these contaminant cells from the
      peritoneal macorphage population was established by adoptive transfer of labelled
      peritoneal cells to cannulated recipients.

PMID- 1027411
TI  - Host resistance to a spontaneously metastasising melanoma after primary tumour
      excision.
AB  - Tumour resistance was investigated in a spontaneously metastasising murine
      melanoma. Specific tumour resistance was found in mice with intact small primary
      tumours and no metastases. If primary tumours were excised, resistance was
      demonstrated in mice which had metastases and in mice which did not have
      metastases but were given crude melanoma homogenate. No resistance could be
      detected in mice which had large primary tumours left intact or in mice which had
      small primary tumours excised four days prior to tumour challenge. These in vivo
      findings are compared with previously documented in vitro results.

PMID- 1027412
TI  - Mechanism of thyroid allograft rejection.
AB  - Balb/c thyroids, held in organ culture for 26 days, survive and function as well
      as isografts for greater than 100 days in CBA recipients. Uncultured allografts
      are totally rejected by 20 days after transplantation. Prolonged allograft
      survival can also be achieved by the treatment of donor animals with
      cyclophosphamide prior to harvesting tissues for transplantation. These
      allografts do not survive as well as 26 day cultured allografts, but
      cyclophosphamide pretreatment reduces the culture time required to achieve
      indefinite survival to 7 days. The provision of an allogeneic (LD) stimulus by
      thyroid tissue that is I-region incompatible with the host does not facilitate
      the rejection of a tolerated cultured allograft. However, activation of the host
      immune system by an uncultured graft syngeneic to a tolerated cultured allograft
      leads to the chronic rejection of the cultured transplant. The transfer of a
      tolerated cultured allograft back to its strain of origin induces an acute
      inflammatory reaction that causes tissue damage within the transplant but does
      not lead to the total destruction of the tissue.

PMID- 1027413
TI  - Studies on the transfer of plasma iron to milk in the lactating rat.
AB  - The transfer of an intravenous does of 59Fe from plasma to milk in the lactating
      rat was a rapid process which accelerated exponentially with time until a plateau
      was reached 2 to 4 hours after injection. This transfer of iron involved little
      participation of the iron in the mammary gland pool. Also, neither the
      lactoferrin of the milk whey nor the iron-carrier molecule of the casein played a
      specific role in the iron transfer process. The present results show that the
      total percentage of plasma 59Fe transferred to the milk and sucklings in the
      lactating rat is much more than those values reported in lactating rabbits
      (Tarvydas, Jordan and Morgan, 1968) and sows (Hansard, 1965).

PMID- 1027414
TI  - The effect of local anaesthetics on the neural uptake of catecholamines in
      isolated arteries--a histochemical study.

PMID- 1027415
TI  - NSW Minister for health on regionalisation and health services.

PMID- 1027416
TI  - Changing pattern of health insurance.

PMID- 1027417
TI  - Sad commentary on our system.

PMID- 1027418
TI  - Regionalisation of health services.

PMID- 1027421
TI  - Death, dying and patient care: the patient and his family.

PMID- 1027422
TI  - Effective use of boards.

PMID- 1027423
TI  - Changing pattern of health insurance.

PMID- 1027424
TI  - Doctor perception of Medibank.

PMID- 1027425
TI  - "Change for all of us...".

PMID- 1027426
TI  - More effective utilisation of nursing resources.

PMID- 1027427
TI  - Side chain oxidation of 1, 25-dihydroxyvitamin D3 in the rat: effect of removal
      of the intestine.

PMID- 1027428
TI  - Conformational states of enkephalins in solution.

PMID- 1027429
TI  - Alkylation of DNA and proteins in mice exposed to vinyl chloride.

PMID- 1027430
TI  - Crystalline anhydrous Ca-phosphatidylserine bilayers.

PMID- 1027431
TI  - Alternate routes for ubiquinone biosynthesis in rats.

PMID- 1027432
TI  - Endo-beta-N-acetylglucosaminidase from fig latex.

PMID- 1027433
TI  - Singlet oxygen formation during hemoprotein catalyzed lipid peroxide
      decomposition.

PMID- 1027434
TI  - Studies of the in vitro sensitivity of iodothyronine synthesis to methimazole in
      normal human thyroid cells.

PMID- 1027435
TI  - Isolation of Coxsackievirus B3 temperture-sensitive mutants and their assignment
      to complementation groups.

PMID- 1027436
TI  - Isolation and initial characterization of human basement membrane collagens.

PMID- 1027437
TI  - The amino acids of M and N blood group glycopeptides are different.

PMID- 1027438
TI  - Glutathione peroxidase activity of glutathione-s-transferases purified from rat
      liver.

PMID- 1027439
TI  - The activity of the erythrocyte monoaccharide transport system is not correlated
      with crosslinkage of band 3 protein.

PMID- 1027440
TI  - Trans-zeatin in culture filtrates of Agrobacterium tumefaciens.

PMID- 1027441
TI  - The NH2-terminus of C-fragment is resistant to the action of aminopeptidases.

PMID- 1027442
TI  - Elevated activities of alpha-2-and alpha-3-fucosyltransferases in human serum as
      a new indicator of malignancy.

PMID- 1027443
TI  - Bestatin, a new specific inhibitor of aminopeptidases, enhances activation of
      small lymphocytes by concanavalin A.

PMID- 1027444
TI  - Distribution of covalently bound benzo(a)pyrene in chromatin.

PMID- 1027445
TI  - Intramolecular determination of primary kinetic isotope effects in hydroxylations
      catalyzed by cytochrome P-450.

PMID- 1027446
TI  - Pool sizes and metabolism of CDPCholine and CDPethanolamine in skeletal muscle.

PMID- 1027447
TI  - Regulation of the meta-cleavage of 4-hydroxyphenylacetic acid by Pseudomonas
      putida.

PMID- 1027448
TI  - Fluorescence emission and stopped-flow kinetic studies of the acid expansion of
      bovine serum albumin.

PMID- 1027449
TI  - [Measurement of electrical impedance in the human body: bioelectrical effects of
      artificially induced venous stasis].

PMID- 1027450
TI  - [Measurement of the electrical impedance of the human body: resistance segments
      of the lower limb].

PMID- 1027451
TI  - [Distribution of lines of electric potential along the lower limb].

PMID- 1027452
TI  - [Action of UML on levels of 5HT and 5HIAA in the rat brain with MAO blocking].

PMID- 1027453
TI  - [Mitochondrial glycogen and morphogenesis in the mouse embryo lung].

PMID- 1027454
TI  - [Histochemical studies of DNA distribution in the brain of albino rats born of
      pregnancies artificially prolonged with progesterone].

PMID- 1027455
TI  - [Relationships between the acoustic pathways and aminergic and cholinergic
      systems in birds].

PMID- 1027456
TI  - [Behavior of the circadian rhythm of LH and FSH gonadotropins in normal women and
      in eumenorrhoic hirsute women: preliminary observations].

PMID- 1027457
TI  - [Comparative study of thyroid activity in various species of mammals at various
      ages].

PMID- 1027458
TI  - [Thyroid activity and hepatic mitochondrial population at various ages in the
      rat].

PMID- 1027459
TI  - [The epithelio-reticular compartment of the thymus gland: function, persistence,
      involution].

PMID- 1027460
TI  - [Effects of phenobarbital on the hepatic microsome metabolism of erythromycin in
      rats].

PMID- 1027461
TI  - [The blastomycete flora of the external ear in humans].

PMID- 1027462
TI  - [Binocular pupillometry for studies of clinical pharmacology].

PMID- 1027463
TI  - [Pupillary pharmacology in idiopathic headache].

PMID- 1027464
TI  - [Electron microscopic study of certain smooth muscle cells of the human renal
      pelvis].

PMID- 1027465
TI  - [Ultrastructure of the thymus gland of the hedgehog (Erinaceus europaeus) during
      wakefulness, hibernation and various phases of re-awakening].

PMID- 1027466
TI  - [Musculature of the gastric antrum in humans].

PMID- 1027467
TI  - [Ultrastructural changes in rat hepatocytes after prolonged exposure to
      nonanesthtic doses of halothane and enflurane].

PMID- 1027468
TI  - [Arterial vascularization of the ulna and radius in humans].

PMID- 1027469
TI  - [Use of an immunochemical test for determination of ESF in some anemic states].

PMID- 1027470
TI  - [Effects of fractional or massive doses of exogenous ESF in uremic patients].

PMID- 1027471
TI  - [Radioimmunological evaluation of plasma renin activity (PRA) in patients with
      hypertension in orthostatism and after stimulation with natriuretic agents].

PMID- 1027472
TI  - [Behavior of sodium and water excretion and of plasma renin activity (PRA) after
      administration of furosemide in patients with glomerulonephritis with various
      degrees of functional deficiency and arterial pressure levels].

PMID- 1027473
TI  - [Electrical impedance of human blood].

PMID- 1027474
TI  - [Depressive type disorders in women taking oral contraceptives: a psychometric
      study].

PMID- 1027475
TI  - Effects of exogenus lithium upon lipid metabolism in rats fed atherogenetic diet.
      (preliminary note).

PMID- 1027476
TI  - [Functional recovery time in a group of athletes exposed to supramaximal exercise
      on the cycloergometer].

PMID- 1027477
TI  - [Cerebral electrical activity and computerized axial tomography: anatomo
      functional findings and correlations (preliminary note)].

PMID- 1027478
TI  - [Influence of serotonin on some enzyme activities in rat organs].

PMID- 1027479
TI  - [Behavior of circulation time during isometric exercise in a group of patients
      with acute myocardial infarct].

PMID- 1027480
TI  - [Behavior of circulation time during isometric exercise in humans].

PMID- 1027481
TI  - [Rheological analysis of macromolecular systems in relation to the dispersion
      medium].

PMID- 1027482
TI  - [Ultrastructure of hepatic cells after administration of glucose and insulin in
      fasting rats].

PMID- 1027483
TI  - [Synthesis of iodoamino acids during in vitro thyroglobulin iodination in
      different states of its molecule].
AB  - Iodotyrosine and iodothyronine residues are formed in the protein molecule during
      bovine thyroglobulin iodination in vitro. Dissociation and reassociation of the
      thyroglobulin molecule have no significant influence on its iodoaminoacid
      composition. Thyroglobulin iodination in the presence of 8 M urea does not result
      in thyroxine synthesis  despite the increased formation of iodotyrosine residues.
      Similarly, during iodination of reassociated thyroglobulin the new molecules of
      thyroxine are not formed either. It is presumed that during reassociation of
      thyroglobulin subunits the native conformation of the protein is not completely
      reconstituted. The results obtained suggest that the structure of thyroglobulin
      controls the distribution of the iodine atoms incorporated by the iodoaminoacid
      residues.

PMID- 1027484
TI  - [Stimulating effect of histones on DNA synthesis in the regenerating rat liver].
AB  - Effect of exogenous histones, nuclear globulins and acid proteins on DNA
      synthesis is studied in regenerating liver of rats in which the synthesis of
      their own proteins and thus DNA replication are inhibited by cycloheximide. In
      these conditions histones from regenerating rat liver are found to stimulate 3H
      thymidine incorporation into DNA of hepatectomyzed rat liver. Nuclear globulins
      and acid proteins from regenerating liver, and histones from intact liver
      produced no stimulating effect on DNA sythesis.

PMID- 1027485
TI  - [Purification and certain properties of pyruvate decarboxylase from bovine
      brain].
AB  - A procedure of isolation and purification of pyruvate decarboxylase (PDC) from
      bovine brain is worked out. 350-fold purified enzyme preparation was homogenous
      under polyacrylamide gel electrophoresis. Molecular weight of PDC from bovine
      brain was estimated to be 180 000 by means of gel chromatography through Sephadex
      G-200. The protein was eluted in two peaks (with molecular weight of 180 000 and
      90 000 respectively). After the treatment of the enzyme preparation with 6 M
      guanidine chloride. Probably, partial dissociation of the enzyme molecule into
      two subunits takes place in this case. Data on paper chromatography confirmed
      that highly purified PDC preparations from bovine brain were isolated as
      apoenzyme, since they were almost free of TPP.

PMID- 1027486
TI  - [Effect of hydrocortisone on methylation and molecular population of DNA in rat
      liver].
AB  - The content of 5-methyl cytosine in rat liver DNA increases 1,7-fold 8 hours
      after intraperitoneal injection of hydrocortisone (5 mg per 100 g animal weight).
      The content of GC, physicochemical parameters (Tm, delta T, etc.) and DNA
      renaturation pattern did not show any changes. No changes were observed in the
      pattern of H3-thymidine incorporation into rat liver DNA: after hydrocortisone
      injection the radioactivity was found to be equally distributed in all isolated
      sequences of DNA, differing in the degree of reiteration (specific
      radioactivities of these DNA, fractions are very similar). Thus, the molecular
      population of DNA in liver cells remains unchanged, which suggests that the
      hormone-induced increase in the 5-methyl cytosine content is due to a change in
      the DNA methylation level. The methyation level of unique sequences (COt greater
      than 600), i. e. that of structural genes, does not undergo any essential
      changes. The reversible methylation of DNA regulated by hormones seems to be one
      of the mechanisms controlling gene activity.

PMID- 1027487
TI  - [Purification and properties of high-molecular-weight rabbit kininogen].
AB  - A preparation of high-molecular weight kininogen (HMWK) was isolated from rabbit
      citrate blood plasma and purified using chromatography on DEAE-Sephadex A-50 and
      CM-Sephadex C-50. From 1 mg HMWK, trypsin or kallikreine of human blood plasma
      release 10 mkg bradykinine. The HMWK preparation is homogeneous during
      electrophoresis in 7.5% polyacrylamide gel in tris-glycine buffer, pH 8.3; its
      electrophoretic mobility corresponds to that of alpha2-globulins. The molecular
      weight of HMWK estimated using the collumn with Sephadex G-200, is 130.000-
      150.000; the sedimentation constant S20w is 7.6. Rabbit HMWK is neither a dimer,
      nor a trimer of low molecular weight kininogen (LMWK), since it does not degrade
      into subunits after treatment by 2.5% solution of sodium dodecyl sulfate,
      containing 8 M urea. 0.05 M 2-mercaptoethanol and 8 M urea induce HMWK splitting
      into 2 fragments with respective molecular weights of 80.000 and 30.000, the
      kinine-containing group being localized in the low-molecular weight fragment.
      Estimation of rates of kinine formation by different kininogenasses from highly
      purified HMWK and LMWK preparations showed that those kininogens are functionally
      different substrates, since blood plasma kallikreines release kinines from HMWK
      at a greater rates, whereas tissue kallikreines, e. g. human saliva kallikreine
      release kinines from LMWK. The specificity of kallikreines as kininogenase, to
      trypsin, was determined. Tripsin removes bradykinine from both kininogens at the
      same rates, which are an order of magnitude less than those found for
      kallikreines.

PMID- 1027488
TI  - [In vitro methylation of nuclear DNA from various organs of a rat: Tissue and age
      differences in acceptor ability of DNA].
AB  - DNA-methylase activities have been found, isolated and partially purified from
      the nuclear and cellular extracts of rat liver, kidneys, spleen, brain and lungs.
      These metylases are capable of methylating in vitro homologous and heterologous
      DNA from rat tissues in the presence of (H3-methyl)-S-adenosylmethionine. The
      radioactive methyl groups incorporated in vitro into DNA were found only in 5
      methylcytosine. No radioactivity was revealed in either N6-methyladenine or N6
      dimethyladenine. Rat spleen DNA-methylase differs in some properties (pH and
      temperature dependences) from those of DNA methylases from other rat organs. This
      enzyme methylates various DNA to a higher extent than DNA-methylases from other
      rat tissues. There may exist a tissue specificity of DNA-methylases from other
      rat tissues. There may exist a tissue specificity of DNA-methylases and a
      different mode of their action and recognition of nucleotide sequences. The
      nuclear DNA from various rat organs methylated in vitro by the same enzyme
      possesses a different ability to accept methyl groups from S-adenosylmethionine:
      there exists a tissue specifity of DNA methylation in vivo and in  vitro. The
      degree of DNA methylation changes with age tissue specifically. Aging is
      accompanied with decrease in the 5-methylcytosine content of DNA of some tissues
      (brain and others) and increase in methyl-accepting capacities of these DNA in
      the in vitro methylation by home- and heterologous DNA-methylases. The age
      changes detected in DNA are correlated with exhaustion of tissue functional
      activity with age and support our previous suggestion that DNA methylation is a
      mechanism for regulation of transcription and gene activity.

PMID- 1027489
TI  - [Study of the membranes of pigment-free mutant of Staphylococcus aureus].
AB  - The membranes from pigmented strain of Staphyloccus aureus 209-P and its apigment
      mutant B-6 were isolated. The infrared spectra, the cytochrome content, and the
      activities of the dehydrogenases and oxidases of the membranes were studied. The
      apigment mutant membranes differed from those of the pigmented strain in all
      parameters studied. It is concluded that the carotenoid pigments affect the
      chemical composition and functional activity of the Staphylococcus membranes.

PMID- 1027490
TI  - [Aspartate transaminase from cytosol of the chicken muscles: Its purification and
      various properties].
AB  - Homogeneous cytosolic aspartate aminotransferase was prepared from chicken
      muscle. The purification procedure involves heat and ammonium sulfate
      fractionation, chromatography on ion-exchage cellulose CM-52 and crystallization
      of the enzyme. A comparison of some properties of aspartate aminotransferases
      from chicken skeletal muscle and heart has been made. Both enzymes were found
      identical in terms of their electrophoretic mobility, isoelectric point,
      pyridoxal phosphate content and the amount of SH-groups.

PMID- 1027491
TI  - [Effect of the conditions of isolation and incubation of the nuclei on digestion
      of DNA chromatin by calcium- and magnesium-dependent endonuclease. Change in the
      spectrum of chromosomal proteins and possible role of DNA-protein interactions].
AB  - Digesting of chromosomal DNA of interphase rat liver nuclei by Ca, Mg-dependent
      endonuclease in situ in the presence of chelating agents results in the
      appearance of the soluble DNP--up to 30% of the total DNA. In addition, 50% of
      the chromatin is solubilised after mild ultrasonication. In the absence of the
      chelating agents the degree of fragmentation is considerably increased. The
      process is accompanied by a loss of some histone and nonhistone chromosomal
      proteins; the nonhistone proteins are lost selectively. The preliminary removal
      of the nuclear membrane and significant part of the proteins by tritone X-100
      promotes the chromatin degradation and the appearance of low molecular weight
      fragments. The DNA-fragments of solubilised chromatin are similar to the DNA
      fragments of residual chromatin, but in the presence of the chelating agents the
      latter does not contain monomeric fragments.

PMID- 1027492
TI  - [Isolation and certain properties of human pituitary prolactin].
AB  - A simple method of isolation of highly purified prolactin from acetonated
      preparations of anterior hypophysial lobes is described. The new method permits
      to obtain higher (about 10-fold) yields of the hormone, as compared to those
      obtained using previously described methods. Prolactin was extracted by acid
      aqueous acetone and was subsequently purified of extract by fractionation with
      acetone and NaCl and by isoelectric precipitation. The final stage of the hormone
      purification involved gel-filtration through Sephadex G-200; prolactin yield was
      400 microgram per 1 hypophysis. The lactogenic activity of the hormone is 14
      MU/mg; the sequence of N-terminal amino acid residues of prolactin is as follows:
      NH2-Leu-Pro-Ile-x-Pro-Leu(?)-Gly-Ala-.

PMID- 1027493
TI  - [Selectivity of lysozyme oxidation by singlet oxygen].
AB  - Peptide analysis of tryptic hydrolysates of two lysozyme forms derived from
      oxidation of lysozyme with singlet oxygen shows that Trp-62, located at the
      active site, is destroyed. This is confirmed by the protective effect of the
      substrate (chitin), whose presense practically prevents the oxidation. A
      possibility of oxidating different tryptophan residues is discussed from the view
      point of their availability to the reagent.

PMID- 1027494
TI  - [Study of reactivity of sulfhydryl groups of troponin].
AB  - The reactivities of SH-groups of troponin and its components were studied, using
      4-chloro-7-nitrobenzo-2-oxa-1,3-diazole (NBD-Cl). At low concentrations of Ca2+
      (pCa greater than 8) one rapidly- and two slowly-reacting SH-groups of troponin I
      and one SH-group of troponin C slowly reacting with NBD-chloride are titrated in
      the whole troponin complex. When Ca2+ concentration is increased up to pCa less
      than 5, only one slowly-reacting and one rapidly-reacting with NBD-chloride SH
      groups of troponin I are titrated. The increase of Ca2+ concentration from pCa
      greater than 8 to pCa less than 5 results in a change of the environment polarity
      for the highly reactive SH-group of troponin I in the whole troponin complex.
      This phenomenon may suggest that the changes in troponin C structure during Ca2+
      binding somehow induce changes in that of troponin I. The half-maximal change of
      troponin SH-groups reactivity is found at pCa 6.8. No cooperativity for Ca2+
      binding by the troponin complex is observed using SH-groups titration by NBD-Cl.

PMID- 1027495
TI  - AV clinic: a model universe.

PMID- 1027496
TI  - Ready, willing and able--the credo for photo staff success.

PMID- 1027498
TI  - Senate hearings on program sponsorship: a bitter pill for the pharmaceutical
      industry?

PMID- 1027497
TI  - Chronicling the cleft-palate case. The television specialist joins the diagnostic
      team.

PMID- 1027499
TI  - Professional competence and the professional organization. Editorial.

PMID- 1027500
TI  - Patients' rights and the psychiatrist's dilemma.

PMID- 1027501
TI  - The role of the lawyer in mental health advocacy.

PMID- 1027502
TI  - Legislative liaison as critical intervention.

PMID- 1027503
TI  - Juvenile court: a behavioral science perspective.

PMID- 1027505
TI  - Guardian's authority to involuntarily hospitalize the incompetent ward.

PMID- 1027504
TI  - Juvenile court: a lawyer's reply to the behavioral science perspective.

PMID- 1027506
TI  - The battered child syndrome--some research aspects.

PMID- 1027507
TI  - On the distinction between medical and legal diagnosis.

PMID- 1027508
TI  - An analysis of demographic variables in adolescent defendants evaluated in a
      forensic psychiatry clinic.

PMID- 1027509
TI  - Adolescent psychopathology in a family court.

PMID- 1027510
TI  - Justice is not a psychiatric term.

PMID- 1027511
TI  - The right to refuse psychiatric treatment: a clinical perspective.

PMID- 1027512
TI  - Collaboration between psychiatry and the law: a study of 100 referrals to a court
      clinic.

PMID- 1027513
TI  - The devil's advocate.

PMID- 1027514
TI  - Public enemy no. 1 to community and mental health: the automobile.

PMID- 1027515
TI  - [Integration of the somatic and psychiatric aspects of chronic alcoholism].

PMID- 1027516
TI  - [The "universal movement of scientific responsibility"].

PMID- 1027517
TI  - [Sino-atrial disease. Electrophysiological study and anatomo-clinical
      comparisons].

PMID- 1027518
TI  - [1-year survival of 54 primary bronchial cancers resected and subjected to active
      non-specific postoperative immunotherapy].

PMID- 1027519
TI  - [Immunologic deficiency and bronchopulmonary pathology (study of secretory IgA in
      10 patients affected with serum IgA deficiency and bronchopulmonary changes of
      congenital origin)].

PMID- 1027520
TI  - [Importance of bronchoscopic and bronchial biopsy diagnosis in sarcoidosis].

PMID- 1027521
TI  - [Pulmonary fibrosis and functional distention of the respiratory passages].

PMID- 1027522
TI  - [Modification of the state of the bronchi at different stages of asthma].

PMID- 1027523
TI  - [Importance of etiopathogenic factors on the characterization of phlogistic
      changes in the bronchi].

PMID- 1027524
TI  - [Open-thorax pulmonary biopsy. Preliminary exploratory surgery in major
      operations in chest surgery].

PMID- 1027525
TI  - [Indications for surgical pulmonary biopsy].

PMID- 1027526
TI  - [Results of biopsies in pleural effusion in suspected malignancy].

PMID- 1027527
TI  - [Efficacy of discontinuous antibiotic treatment in the fall-winter season in
      subjects stricken with chronic bronchitis].

PMID- 1027528
TI  - Peripheral occlusive arterial disease in Sri Lanka.

PMID- 1027529
TI  - Prevalence of soil-transmitted helminths in the Hindagala community health
      project area.

PMID- 1027530
TI  - Preventive aspects of paediatric surgery.

PMID- 1027531
TI  - Vaginal sterilisation.

PMID- 1027532
TI  - A comparative trial of sulphadoxine and tetracycline in the treatment of cholera.

PMID- 1027534
TI  - A case of ulcerative colitis.

PMID- 1027533
TI  - Infantile glaucoma associated with neonatal rubella.

PMID- 1027535
TI  - The ombudsman in mental health: Lakeshore's experience.

PMID- 1027536
TI  - Group therapy training in a mental hospital.

PMID- 1027537
TI  - The evolution of the legal status of mental patients in Quebec and Ontario--a
      comparison.

PMID- 1027538
TI  - Toward evaluating the meaningfulness of legal counsel for psychiatric patients.

PMID- 1027539
TI  - Is Tylenol (et al) any better than aspirin?

PMID- 1027540
TI  - Swine flu: did Uncle Sam buy a pig in a poke?

PMID- 1027541
TI  - Steroid-induced, steroid-producing, and steroid-responsive tumors.

PMID- 1027542
TI  - Radioiodinated estrogens and antiestrogens as potential imaging agents.

PMID- 1027543
TI  - Selecting endocrine therapy in breast cancer.

PMID- 1027544
TI  - Fractionation of diverse steroid-binding proteins: basic and clinical
      applications.

PMID- 1027545
TI  - RNA synthesis in nuclei of rat liver and of human lymphocytes.
AB  - Physico-chemical properties and RNA synthesis in the rat liver and human
      lymphocytes have been compared in a nuclear system in vitro. Human lymphocytes
      were isolated from blood of healthy donors and of chronic lymphocytic leukaemia
      patients. The isolated nuclei served as the source of polymerase and template
      DNA. 3H-CTP was incorporated into the acid insoluble fraction linearly for 60
      min. The nuclei of lymphocytes contained small amounts of RNA and protein, and
      the isolation procedure was complicated. Rat liver nuclei seem to be less prone
      to clumping at high pH values and may incorporate much more 3H-CTP. The nuclear
      synthesis was compared with incorporation of 3H-rU and 32P-orthophosphate into
      nuclear RNA of intact lymphocytes. Normal cells easily incorporated 32-P, and in
      contrast leukaemic cells incorporated 3H-rU to a greater extent.

PMID- 1027546
TI  - Effect of aminonucleoside on the stability of rat liver ribosomal RNA to heating.
AB  - High molecular weight ribosomal RNA has been isolated from normal rat liver and
      from the livers of rats treated with aminonucleoside. Melting curves of the rRNA
      from treated rat livers were shifted to higher temperatures. The melting
      temperatures were found to be 62.5 and 66 degrees C for normal and treated
      material respectively. The rRNA was heated at different temperatures and analysed
      by polyacrylamide gel electrophoresis. In both normal and treated material, the
      18 S was more stable in the treated material when compared with the control
      material.

PMID- 1027547
TI  - Chloroplast fine structure in the japonica-2 maize mutant exposed to continuous
      illumination. 1. The green tissues.
AB  - Exposure to continuous illumination causes the appearance of numerous
      plastoglobuli in the stroma of both the mesophyll and bundle sheath chloroplasts
      of the green tissues of the leaves of the japonica-2 mutant of maize. In the pale
      green tissues the thylakoids have markedly swollen membranes. Another feature of
      the plastids exposed to continuous illumination is the heavy accumulation of
      starch. The japonica-2 chloroplasts show a different sensitivity to light, the
      chloroplasts of the pale green tissues being affected more markedly than the ones
      of the dark green tissues, and the bundle sheath chloroplasts more than those of
      the mesophyll. The effects of continuous illumination may be interpreted as an
      acceleration of chloroplast ontogenesis.

PMID- 1027548
TI  - Chloroplast fine structure in the japonica-2 maize mutant exposed to continuous
      illumination. 2. The white tissues.
AB  - Exposure to continuous illumination causes an enhancement of thylakoid swelling
      in the mesophyll chloroplasts of the white tissues of the japonica-2 maize
      mutant. In the bundle sheath plastids the effects of continuous illumination are
      striking and intriguing, because a regular honeycomb-like fret of membranes is
      formed from a provesicular body. No interpretation of this fret of membranes is,
      at present, possible.

PMID- 1027549
TI  - Lymphocyte transformation in newborns, women and those who had used oral
      contraceptives.
AB  - Lymphocyte transformation, utilizing the mitotic index parameter has been
      assessed in newborns' cord blood, adults and women who had been on oral
      contraceptives and their babies. The results show that the newborns' cord blood
      response is significantly higher to PHA when compared with the respective adults'
      response. No significant difference was observed between the women taking oral
      contraceptives and their respective controls.

PMID- 1027550
TI  - A scanning electron microscopic study of trichomes of IAA-induced tumours in bean
      embryos (Phaseolus vulgaris L.).
AB  - A scanning electron microscopic study of trichome morphology of bean embryo,
      growing in semi-solid synthetic medium, has been undertaken. The work shows some
      distinct differences in trichome morphology as well as variation in their
      development, due to the effect of indole-3-acetic acid (IAA).

PMID- 1027551
TI  - Appearance and accumulation of the brain specific S 100 protein in the developing
      nervous systems of rat, rabbit and guinea pig.
AB  - The appearance and accumulation of S 100 protein during postnatal development of
      rats and rabbit, and during pre- and postnatal development of guinea pig, was
      studied quantitatively by immunoelectrophoresis. High amounts of S 100 were found
      in newborn guinea pig brain. In rabbit and rat central nervous systems the
      content of S 100 rose linearily between the 1st and the 3rd and 4th weeks of
      postnatal life, respectively. From this later period to the adult animal there
      was a small increase in the amount of S 100 in rabbit and rat brain. The results
      of this study are compared with other studies on S 100 accumulation during
      postnatal development of rat, rabbit and guinea pig, using immunofluorescence and
      immunoelectron microscopic techniques.

PMID- 1027552
TI  - [Regeneration of the rat liver after subtotal resection (75 percent of the
      parenchyma). Anatomo-functional study. Note I].

PMID- 1027553
TI  - [Homeostatic regulation of the circulation in orthostatism].

PMID- 1027554
TI  - [Disease of the striated sphincter of the urethra].

PMID- 1027555
TI  - Structural and functional organization of the ovocytes in Trachurus trachurus
      trachurus L.

PMID- 1027556
TI  - Treatment of traumatic urethral lesions.
AB  - From 1955 to 1975 the author has treated 705 patients with stricture of the
      urethra. He has elaborated his own procedure consisting of radical excision of
      the stricture and scar tissues with end-to-end anastomosis. In cases of long
      strictures, reconstruction of the urethra has been by the use of a scrotal flap.

PMID- 1027557
TI  - The importance of the bladder washout technique in the management of a solitary
      calyceal stone.
AB  - Renal infection is an indication for surgical treatment of a solitary calyceal
      stone. It must be proved however, that the infection is localised to the kidney
      before deciding on operation, as this may be very difficult and produce severe
      complications. Bladder washout seems to be an excellent technique to
      differentiate the localisation of the infection.

PMID- 1027558
TI  - Management of ureteric obstruction in the solitary kidney by a segmental
      suspended ureteric prosthesis.
AB  - Ureteric obstruction of a single kidney, secondary to an aorto-iliac bypass
      graft, was treated with a suspended segmentary ureteric prosthesis. No urinary
      stasis was observed during 1 year and the urodynamic implication are discussed.

PMID- 1027559
TI  - Prevention of reflux by a ureteric intussusception valve: a preliminary study on
      dogs.
AB  - In 10 dogs in anti-reflux procedure by intussusception of the ureter is examined.
      The surgical procedure is developed and the urinary flow and prevention of the
      anti-reflux valve are explored. The study shows that an invagination is
      technically possible and that reflux can be prevented in half the cases without
      significant obstruction of the urinary flow.

PMID- 1027560
TI  - The influence of various drugs on artificial oedema of the rat's bladder.
AB  - An experimental oedema of the bladder wall was produced by electric coagulation
      current in 130 rats. The amount of oedema was calculated by determination of the
      difference between the weight of the freshly excised wet bladder and that after
      drying to constant weight. Thus, oedema of a fairly constant and reproducible
      amount could be produced. The effect of three different drugs on such oedema was
      tested (Na-Aescinat, 6-methylprednisolone, alpha-Chymotrase). After the
      application of Na-Aescinat and 6-methylprednisolone no significant oedema could
      be measured after 48 h. Using alpha-Chymotrase, there was no measurable influence
      on the oedema.

PMID- 1027561
TI  - Fibroelastosis of the posterior urethra associated with urinary, cardiac and
      digestive anomalies.
AB  - A case of fibroelastosis of the posterior urethra associated with ectopic opening
      of the ureter of a solitary kidney in the urethra is described. Oesophageal
      atresia and anomalous origin of the left coronary artery were also observed.
      Management of fibroelastosis is pointed out.

PMID- 1027562
TI  - A successfully treated case of condyloma acuminatum of the urethra and urinary
      bladder.
AB  - Condyloma acuminatum very seldom affects the urinary bladder, but if it does
      conservative treatment has been considered of little value and cystourethrectomy
      will eventually be required. A case with urethrovesical condyloma is presented,
      where repeated transurethral resections cured the patient.

PMID- 1027563
TI  - A transpubic approach to radical prostatectomy.
AB  - A transpubic approach to radical prostatectomy is presented in a series of 15
      cases. The main advantages and some typical complications of this approach are
      described.

PMID- 1027564
TI  - [Structure of the cholinoreceptors].
AB  - The results of research works of a number of Soviet authors concerned with the
      structure of cholinoreceptors based on their response to cholinomimetics and
      cholinolytics are summarized. A brief review of foreign research involving
      separation of cholinoreceptors "in vitro" is given.

PMID- 1027565
TI  - [Pharmacokinetic study of the neuroleptic, azabutyrone].
AB  - By using gas-chromatographic and spectrophotometric assays and adopting
      pharmacokinetic models of various types the pharmacokinetics of the neuroleptic
      azabutyron in the plasms, bile, gastric juice and urine of rabbits and rats was
      studied. The maximum level of azabutyron in the plasma (27  gamma/ml) was
      recorded 5 minutes after introduction of the drug. The amount of unchanged
      azabutyron passed with urine comprises 2--4 pc of the dose actually introduced,
      while the quantity of the agent excreted together with the bile and gastric juice
      was below 1 pc. The results thus obtained were subjected to electronic data
      processing according to the two-compartment pharmacokinetic model. It is presumed
      that in order to properly explain the pharmacokinetics of azabutyron some models
      of a greater complexity have to be used.

PMID- 1027566
TI  - [Effect of thyrocalcitonin on the pain sensitivity in animals].
AB  - With a single parenteral introduction of thyrocalcitonin (TCT) the algesthesia of
      soft tissues (tall skin, paw) is moderately increasing, while the algesic action
      of morphine and promedol against the background of TCT-gets weaker. And
      contrarywise algesthesia of hard tissues of the tooth becomes significantly lower
      under the effect of TCT and this continues for a long time.

PMID- 1027567
TI  - [Use of parameters of ionic permeability and mechanical activity for the rating
      of interaction of acetylcholine with the smooth muscle M-cholinoreceptors].
AB  - When employed in high concentrations (1-10(-5)-1-10(-3) g/ml) acetylcholine (ACC)
      causes an accrued uptake of Na22 and liberation of Rb86 (K) from smooth muscles
      of the rat's stomach. An increased release of Ca45 occurs in concentrations of 1
      10(-7) g/ml and higher. The contractile reaction is recorded under the action of
      lower ACC concentrations (starting from 1-10(-9) g/ml). The observed changes in
      the ionic permeability and tonicity are due to the ACC action on the M
      cholinoreceptors of the muscles. A comparison of emipirical relation between the
      effects and the concentration against the theoretical one showed that it is only
      the incorporation of Na22, liberation of Rb86 pand the contractile reaction in a
      depolarizing solution that adequately reflect the ACC interaction with
      cholinoreceptors of the smooth muscles in the rat's stomach.

PMID- 1027568
TI  - [Antiarrhythmic activity of trimecaine in experimental arrhythmia and its effect
      on the heart conduction system].
AB  - The anesthetic trimecaine is shown to be capable of eliminating the flutter of
      atria in dogs simulated by an electric stimulation of the myocardium and atrial
      fibrillation in cats induced with aconitin and precludes ventrical fibrillation
      in rats arising due to intoxication with calcium chloride. Trimecaine noticeably
      mitigates the toxic effect of strophanthin. While depressing the automatism of
      the sinoatrial node the drug does not affect the conduction function.

PMID- 1027569
TI  - [Effect of Soviet-made prostaglandin E1 on the aggregation of thrombocytes and
      erythrocytes].
AB  - The effect of prostaglandin E1 in a concentration of 0.1 gamma/ml on the
      aggregation and disaggregation of thrombocytes and erythrocytes in vitro was 
      studied. Prostaglandin E1 was found to materially reduce the  aggregation and to
      produce disaggregation of thrombocytes. A somewhat diminished aggregation of
      erythrocytes was also noted. Prostaglandin E1 failed to cause disaggregation of
      erythrocytes.

PMID- 1027570
TI  - [Study of interaction between contrast media and human serum albumin by the
      fluorescence method].
AB  - Structural changes in the human serumal albumin under the effect of roentgen
      contrast media, viz. bilignost, triiotrast, endografine, iodamide, triombrine and
      cardiotrast, were investigated by the method of fluorescence. The complex
      formation of albumin with triiodotrast, bilignost and endografine was shown to
      call forth a short-wave shift of the fluorescence peak by approximately 20 nm.
      The binding section for these substances is characterized by an association
      constant equalling 1.2-10(5) M-1. The authors presume that triiodotrast,
      bilignost and endografine cause changes in the microstructure of the aqueo
      protein layer in the area of the tryptophan residue localization. As to
      triombine, iodamide and cardiotrast fluorescence failed to disclose their
      combination with the human serumal albumin.

PMID- 1027571
TI  - [Characteristics of liver circulation and the outflow of bile and lymph in acute
      carbon tetrachloride poisoning].
AB  - In acute tests set up on 13 dogs the pressure and blood flow in the portal vein
      and hepatic artery, the pressure in the inferior vena cava along with lymph- and
      bile currents were registered following intraportal introduction of CCI4. Subject
      to determination were also the resistance of venous and arterial hepatic vessels
      and of the splachnic zone, as well as the summary blood flow. The rising pressure
      and diminished blood flow in the portal vein were found to be the result of the
      growing resistance of venous vessels in the liver. Falling pressure and reduced
      blood flow in the hepatic artery bore witness to the general toxic effect of CCl4
      on the animal organism. Increased portal pressure and disturbed permeability of
      biological membranes was attended  by a greater lymph outflow. The inhibition of
      bile secretion came as a result of hypoxic and toxic damage of the liver.

PMID- 1027572
TI  - [Histological changes in the liver and lungs of rabbits after experimental
      hepatography with iophendylate emulsion].
AB  - Hepatography with a 75% iodophendylate emulsion was carried out in 21 rabbits to
      which the contrast medium had been introduced after laparotomy in a dose of 0.84
      1.9 g/kg. The roentogenological and histological dynamics and the liver
      contrasting was studied in its continuity. In experimental hepatography the
      emulsification of iodophendylate does not cause any damaging effect on the liver
      and the lungs. In the mechanism of the emulsified iodophendylate elimination of
      prime importance are phagocytic cellular reactions on the part of lympho- and
      histocytic elements.

PMID- 1027573
TI  - [Effect of mellaril on the liver lysosomes of rats with acute toxic hepatitis].
AB  - In 24 hours after a single administration of melleril (30 mg/kg) an elevated
      injuriousness of "heavy" and "light" liver lysosomes of rats subjected to "in
      vitro" treatment with a pH 5.0 solution at 37 degrees was recorded. Introduction
      of melleril to rats with toxic CCl4-induced hepatitis (CCl4 dosage of 0.15 ml per
      100 g body weight) depresses free activity of acid phosphatase, this fall,
      however, failing to reach the corresponding values in intact animals. An elevated
      injuriousness of "heavy" and "light" lysosomas undergoing treatment at pH 5.0 and
      37degrees, revealed in all variants of the tests, is related to activation of
      lysosomal phospholipases with subsequent liberation of surfactant lipids and
      volumetric changes of the particles.

PMID- 1027574
TI  - [Effect of metaphos on the bile-forming function of the liver].
AB  - In experiments with albino male rats the effect of a single introduction into the
      stomach of methaphos in doses of DL50, 1/10 DL50, 1/20 DL50, 1/50 DL50 and also
      of a daily consumption of the compound for a month was studied. Metaphos was
      found to exert a manysided action on the cholopoietic function of the liver, viz.
      it increases the intensity of the bile secretion, inhibits the synthesis of
      primary bile acids and conjugation of cholic acid with taurine and glycine,
      stimulates the formation, conjugation and secretion of bilirubin.

PMID- 1027575
TI  - [Antifibrotic properties of lidase in experimental berylliosis].
AB  - The effect of lidase with its inhalation against the background of a fibrotic
      process in the lungs was studied on a model of experimental berylliosis provoked
      in rats through intratracheal administration of 5 mg of Be (OH)2. The degree of
      fibrosis was assessed according to the dry residue in the lungs, content therein
      of oxyproline, hexosamines and hexuronic acids. Lidase was found not only to
      delay the development of the affections but also to lower the level of fibrosis
      existing prior to the treatment. The therapeutic effect of the compound continued
      for a comparatively long time.

PMID- 1027576
TI  - [Modulation of the receptors during interaction with pharmacologically active
      substances (review of the literature)].

PMID- 1027577
TI  - Food quality and control. New developments in food production and processing
      techniques require new methods of control for consumer protection.

PMID- 1027578
TI  - Mycotoxins: the FAO programme.

PMID- 1027579
TI  - Evaluation of supplementary feeding programmes assisted by the World Food
      Programme.

PMID- 1027580
TI  - Absence of Leydig cells in the mature testis of the lizard Lygosoma himalayanum.

PMID- 1027581
TI  - On the localisation of hydroxysteroid dehydrogenases in the testis of the skink,
      Mabuya carinata.

PMID- 1027582
TI  - Studies on the incidence of normal and pathological termination of pregnancies in
      dairy animals.

PMID- 1027583
TI  - Morphology of cock spermatozoa in relation to fertility and hatchability of eggs.

PMID- 1027584
TI  - A note on occurrence of immuno-reactive prolactin in bovine semem.

PMID- 1027585
TI  - Effect of oxytocin on conception rate in buffaloes.

PMID- 1027586
TI  - Cations of ram semen as related to some physical attributes.

PMID- 1027587
TI  - A note on partially defatted cow milk as a dilutor for buffalo bull semen
      preservation.

PMID- 1027588
TI  - A note on serum luteinizing hormone during the oestrous cycle and early pregnancy
      in Indian buffaloes.

PMID- 1027589
TI  - Secondary sex ratio in Sahiwal cattle.

PMID- 1027590
TI  - Fructolysis index in the semen of buffalo, Jersey and Friesian cattle at
      different ages.

PMID- 1027591
TI  - A note on studies on factors affecting seminal traits in Nali rams.

PMID- 1027592
TI  - Spermatogenic cells of the buffalo (Bubalus bubalis) testis.

PMID- 1027593
TI  - Abortion laws in commonwealth countries.

PMID- 1027594
TI  - The effects of ablation of the septal nuclei in the rat on circadian variation
      and stress response pattern of corticosterone, growth hormone and prolactin.

PMID- 1027595
TI  - Twenty-two dimensions of the population problem.

PMID- 1027596
TI  - World fertility, 1976: an analysis of data sources and trends.

PMID- 1027597
TI  - [Therapeutic attempts in unspecific sterility of cattle using intravenous
      triiodide administration].

PMID- 1027598
TI  - [Utilization of semen samples, recovered from the genitalia of the hog
      immediately following copulation, for the spermatological control of inseminating
      boars].

PMID- 1027599
TI  - [Studies on the continuing fertility of cattle following surgical delivery in
      comparison with spontaneous birth].

PMID- 1027600
TI  - [Density gradient centrifugation of rabbit semen and sex-ratio of the progeny
      (author's transl)].

PMID- 1027601
TI  - [Retrograde ejaculation in the dog (author's transl)].

PMID- 1027602
TI  - [The influence of female genital tract fluids on the proteo(gelatino)lytic
      activity of ejaculated boar spermatozoa (author's transl)].

PMID- 1027603
TI  - [The effects of experimental heart stress on some ejaculate characteristics of
      rabbits (author's transl)].

PMID- 1027604
TI  - [Fertility results and prenatal mortality following artificial insemination with
      fresh and deep frozen semen in rabbits after normal induction of ovulation and
      super-ovulation (author's transl)].

PMID- 1027605
TI  - [Uterusbiopsy in the diagnosis of infertility in the mare (author's transl)].

PMID- 1027606
TI  - Value of cyclic hormonal assessment by vaginal cytology in infertile women.

PMID- 1027607
TI  - Action of prostaglandins on the contractility of pregnant human uterus.

PMID- 1027608
TI  - Intra-amniotic injection of 20% mannitol for medical termination of pregnancy.

PMID- 1027609
TI  - Some experience in legal abortions.

PMID- 1027610
TI  - Social aspect of family planning.

PMID- 1027611
TI  - Vaginal ligation of tubes with termination of pregnancy.

PMID- 1027612
TI  - Serum human placental lactogen (HPL) levels in normal pregnancy.

PMID- 1027613
TI  - Clinico-bacteriological studies with intra-uterine administration of
      prostaglandin for induction of abortion.

PMID- 1027614
TI  - A clinical study on the mode of action of I.U.D.

PMID- 1027615
TI  - Intrauterine contraceptive device-nuclei and nucleolar study of the endometrial
      glands after three years of use.

PMID- 1027616
TI  - Clinical, hormonal and metabolic studies in patients undergoing second trimester
      abortion with prostaglndin F2 alpha, 15(S)-15-methyl0PGF2 alpha and hypertonic
      saline.

PMID- 1027617
TI  - A comparative study of placental  villous changes in normal and abnormal
      pregnancies.

PMID- 1027618
TI  - Studies on serum lipids and lipase activity in women using oral contraceptives.

PMID- 1027619
TI  - Report on studies of immunological aspects of sterility.

PMID- 1027620
TI  - Unexplained infertility and ABO blood group incompatibility.

PMID- 1027621
TI  - Long term effect of intrauterine devices: cytomorphological and cytohormonal
      study.

PMID- 1027622
TI  - Study of vaginal cells during menstrual cycle, normal and abnormal pregnancy.

PMID- 1027623
TI  - Effects of Lippes loop--5 years and beyond.

PMID- 1027624
TI  - Menstrual regulation.

PMID- 1027625
TI  - Male factor in sterility.

PMID- 1027626
TI  - Hypertonic solutions in mid-trimester abortions a comparative analysis of
      different solutions and different methods.

PMID- 1027627
TI  - Evaluation of prostaglandin F2 alpha and hypertonic saline as abortifacients.

PMID- 1027628
TI  - Intra-amniotic injection of hypertonic saline through cervical canal.

PMID- 1027629
TI  - Post-saline vaginal ligation of tubes.

PMID- 1027630
TI  - Statistical evaluation of effectiveness and acceptability of IUCD programme.

PMID- 1027631
TI  - The reproductive cycle in the male polecat Putorius putorius in Britain.

PMID- 1027632
TI  - An in vitro method for screening compounds for the effect on the rate of sickling
      of erythrocytes.
AB  - Since no practical animal model is available for the evaluation of compounds in
      vivo, we have developed an in vitro model for determining the effect of compounds
      on the rate of sickling of erythrocytes in whole blood taken from patients with
      sickle cell anaemia. RMI 6792 (a phenethanol-diamine derivative), procaine, and L
      glutamine were tested in this in vitro system. RMI 6792 was tested at various
      concentrations in whole blood. The data indicate that RMI 6792 decreased the rate
      of sickling at and above 60 microgram/ml. Procaine slightly decreased sickling
      rate at 100 microgram/ml. L-glutamine at 555 had no inhibitory effect. RMI 6792
      and procaine had no effect on the oxygen dissociation curve. RMI 6792 affected
      the calcium flux of the erythrocytes and the calcium concentration in the
      erythrocytes.

PMID- 1027633
TI  - Serum quinidine levels after chronic administration of four different quinidine
      formulations.
AB  - The serum levels produced by four different quinidine formulations have been
      studied. The relative bioavailability of the formulations was demonstrated as
      were the mean peak serum levels and their timing in relation to dosage. From the
      data obtained, the biological half-lives were measured and the apparent volume of
      distribution and total body clearance were calculated for each formulation. The
      generic tablets of quinidine monosulphate from five different manufacturers were
      not significantly different from each other in any respect and produced the
      expected peak and trough serum level curves. The serum level curves resulting
      from administration of quinidine polygalacturonate (Cardioquin) were not
      significantly different from those resulting from the generic tablets, and this
      formulation may be regarded as therapeutically equivalent to the generic
      formulations. Both sustained-release formulations of quinidine bisulphate,
      Durettes and Kiditard (given at the same dosage) were shown to offer a means
      whereby, with simple twice-daily dosage, quinidine maintenance treatment may be
      continued with the confidence that the serum levels may be maintained throughout
      each 24-hour period without peaks into the toxic levels and troughs into the
      levels of no effect.

PMID- 1027634
TI  - Systemic and coronary haemodynamic effects of the new hypotensive drug L 6150.
AB  - The acute systemic and coronary haemodynamic effects of a new hypotensive drug L
      6150 (3-hydrazino-6-[N,N-bis(2-hydroxyethyl)amino]pyridazine) have been studied
      in six patients with renal or essential hypertension. The drug, administered
      intravenously at a dose of 2-9 mg, caused a marked hypotension and increase of
      cardiac output in five cases. Though left ventricular work was reduced or
      unchanged after the drug, myocardial blood flow increased markedly, coronary
      resistance decreased and coronary A-V oxygen difference decreased by about 50%
      indicating coronary vasodilation. When compared with the available data on the
      effects of hydrazinophthalazine, L 6150 appeared to have qualitatively similar
      effects, but a somewhat greater direct coronary vasodilator effect.

PMID- 1027635
TI  - A trial of Fortagesic and Paramol 118 in osteoarthritis.
AB  - Fortagesic was compared with Paramol 118 in a fourteen day single-blind crossover
      study in patients with moderate pain due to osteoarthritis. Both preparations
      were shown to be similarly effective. More side-effects were seen with Paramol
      118 than with Fortagesic and more patients preferred Fortagesic. These
      differences were not statistically significant, but it is concluded that
      Fortagesic is a useful effective analgesic for standard use in moderate pain.

PMID- 1027636
TI  - Pharmacokinetics of amoxycillin according to administration schedule.
AB  - Thirty subjects, free of any heart, kidney or liver disease, were given the same
      dosage of amoxycillin--100 mg/kg/24 hr. The first ten were given the drug in
      three equal doses at 8-hourly intervals, a further ten in four doses at 6-hourly
      intervals, and the last ten in eight doses at 3-hourly intervals. The final
      administration schedule resulted in much higher and more regular serum levels of
      amoxycillin than the other two, suitable for the treatment of severe infectious
      conditions, and has the advantage of avoiding prolonged antibiotic infusions
      which are a source of venous complications in the patient. The first results
      obtained clinically, which will be published in a further paper, seem favourable.

PMID- 1027637
TI  - [Cervical mucus with special references to the spermatozoa behaviour (author's
      transl)].

PMID- 1027638
TI  - [Social psychological and sexological aspects of oral contraception (author's
      transl)].
AB  - An inventory is made on the hindrances to the acceptance of contraception in
      general and oral contraception in particular. They are grouped as hindrances
      related to the social and psychological significance of "making children",
      hindrances related to the social and psychological significance of "having
      children" hindrances, related to the method of oral contraception itself, to be
      divided in social hindrances, psychological hindrances and medical hindrances and
      finally hindrances related to the provision of the pill to the individual user.
      Each of these is amply discussed, the author expresses the hope that by
      identification of these hindrances, lessons may be learned for the future, when
      other methods of contreception become available.

PMID- 1027639
TI  - Ovarian dysgerminoma, investigations on cell-and humoral-mediated immunologic
      reactions.
AB  - A 17-year-old girl with repeated ovarian dysgerminoma is described. Postoperative
      immunologic investigations prior to irradiation showed a transient increased cell
      -an humoral--mediated immunologic responsiveness of the patient for approximately
      2 1/2 months. After irradiation, a markedly defective response to PHA was
      observed which improved when reexamined 11 months later. The patient is well 22
      months after the second operation.

PMID- 1027640
TI  - [How to stimulate the placental function (author's transl)].
AB  - Imminent abortion, habitual abortion and threatened premature labor, all
      constitute difficult clinical problems. Those cases require on every occasion a
      diagnosis as acurate as possible, and unfortunately our present methods of
      biochemical determinations only represent a means to evaluate placental function.
      On those cases where a faulty placental function is detected thru the tests
      presently available, the authors recommend the utilization of a placentotropic
      substance, Gestanon, that is capable to stimulate and normalize the placental
      function, a is demostrated by the statistical results published in the
      international medical bibliography.

PMID- 1027641
TI  - [Bovine milk progesterone concentration as a method of early diagnosis of
      pregnancy (author's transl)].
AB  - With the purpose of obtaining an early indicator of pregnancy in bovines,
      excretion levels of milk progesterone were determined by a simple
      radioimmunological method. In the pregnant group, progesterone concentration was
      significantly (p less than 0,001) greater than in non-pregnant ones. In some
      cases (20-25%) there was no difference in values, resulting a method efficiency
      of 75-80%. Milk must be processed a few hours after collection since a decrease
      in progesterone values is observed within a few days. Easy obtention of this
      biological matherial, without special technical requirements as well as the
      simple dosification method make this test a practical index for establishing
      early diagnosis of pregnancy in bovines.

PMID- 1027642
TI  - [Copper concentration in women endometrium and in peripheral blood after
      prolonged use of intrauterine devices (author's transl)].

PMID- 1027643
TI  - [Medical and socio-demographic implications of abortion at Felix Bulnes Hospital
      in Santiago (author's transl)].

PMID- 1027644
TI  - [Potscoital test (author's transl)].

PMID- 1027645
TI  - [Post-pill amenorrhea and anovulation (author's transl)].
AB  - The numerous pregnancies that occur as early as the first cycle after the
      discontinuation of an oral contraceptive prove that in general ovulation
      reappears  immediately and that after a period of "rest" more or less prolonged
      the ovaries reasume their normal function very rapidly. However, in less than 1%
      of the cases the discontinuation of oral contrecption is followed by anovulation
      or even amenorrhea. The authors try to find an explanation to this over
      supression syndrome and review the different treatments that have been proposed
      in the bibliography, but keeping in mind that within a year 14% of the
      anovulations and 5% of the amenorrbeas will have disappeared spontaneously.

PMID- 1027646
TI  - New evidences on the first appearances of the semicircular duct, cristae and
      cupulae in human embryos.

PMID- 1027647
TI  - [Ultrastructure function and regulation of the oviduct of the Rana ridibunda
      (author's transl)].
AB  - An investigation has been carried out into the structure, ultrastructure,
      function and of the oviduct on the adult female of Rana ridibunda. The most
      important part of the oviduct comprises tubulary glands and a luminal epithelium
      which is composed of ciliated cells and vesicular cells. The discharge processes
      of secretory substances were studied. Injection of the mature females with
      estrogens and progesterone have show that progesterone was the most effective in
      provoking jelly release. It is probably that in Rana ridibunda the pituitary
      hormones act on the follicle cells of ripe oocytes, causing them to secrete a
      progesterone-like hormone which provodes the maturation of the oocytel and jelly
      release from the oviducal glands.

PMID- 1027648
TI  - Critical closing pressure in the fetal vessels of the human placenta in vitro I.
      general characteristics, and spontaneous and induced variations.

PMID- 1027649
TI  - Scrotal circumference measurements in 764 beef bulls.

PMID- 1027650
TI  - Non-surgical recovery of bovine eggs.

PMID- 1027651
TI  - Corpus luteum function in the guinea pig: effect of pgf2 alpha and inhibitors of
      prostaglandin and progesterone biosynthesis.

PMID- 1027652
TI  - Artificial insemination of sheep: the fertility of semen extended in diluents
      containing egg yolk and inseminated soon after dilution or stored at 5 degrees C
      for 24 or 48 hours.

PMID- 1027653
TI  - Antibodies to egg yolk in blood serum of rabbits and cattle and cervical mucus of
      cattle inseminated artificially.

PMID- 1027654
TI  - [Effect of indomethacin on the plasma renin activity in patients with arterial
      hypertension].

PMID- 1027655
TI  - [Renal function in the aged].

PMID- 1027656
TI  - [Laboratory tests in diabetology: value and limitations].

PMID- 1027657
TI  - [Comments on "Replacement surgery in paralysis of the thenar muscles" (R.
      Tubiana, Paris)].

PMID- 1027658
TI  - [A new technic for the correction of malunited distal radius fractures].
AB  - After malunited fractures of the distal radius the original anatomy of the wrist
      joint can be restored only by osteotomy of the radius and interposition of a
      cortico-cancellous bone block. This procedure has been shown to be much easier
      using a new bone plate for internal fixation. The plate is applied to the radius
      volarly through a radio-volar approach. The correcting angles can be adjusted
      easily. The stable osteosynthesis allows early postoperative motion. In cases of
      osteoarthritic changes the procedure may be combined with a denervation of the
      wrist joint (A. WILHELM).

PMID- 1027659
TI  - [A rare form of median nerve injury during elbow dislocation].
AB  - The following is a report concerning a rare complication in the case of an elbow
      luxation. In the course of repositioning, the nervus medianus slipped into the
      joint cavity, causing total paralysis of the nerve medianus. Operative revision
      of the nerve and restoration through interfascular nerve transplantation. Results
      one half a year after the operation are already satisfactory. Since this
      complication does not sand in immediate connection with the accident, and in
      consequence representing a serious injury, besides being very rare--the
      literature produced only 6 cases--we see ourselves induced to further discuss the
      mechanism of injury and the problems of such an accident, and to point out the
      necessity of an early revision.

PMID- 1027660
TI  - [Problems of treating the clubhand in dysmelia syndrome (thalidomide
      embryopathy)].
AB  - In our follow-up examination of about 500 children suffering from thalidomide
      embryopathy we have studied the results of conservative and operative treatment
      of club hand. The results of treatment have not corresponded to the prognosis
      with regard to function. In our opinion the possibility of operative treatment
      should not be considered until growth of the ulna ceases.

PMID- 1027661
TI  - [Familial occurence of Martin-Gruber anastomosis].
AB  - 1. A Case of MARTIN-GRUBER anastomosis detected intraoperatively is reported. 2.
      The two children of the above patient also showed a MARTIN-GRUBER anastomosis.
      The phenomenon was proved by EMG and local anaesthesia.

PMID- 1027662
TI  - [Tenosynovitis nodosa].
AB  - Nodular tenosynovitis occurs in a localized and in a diffuse form. The histologie
      finding are rather variable. According to electron microscopic studies nodular
      tenosynovitis originates in the synovial membrane. Mainly there are two types of
      cells to be found in the tumor: Type A, similar to macrophages - type B, similar
      to fibroblasts. The localized form of nodular tenosynovitis has a higher
      incidence in woman and occurs predominantly in the hand. The clinical symptoms
      are not characteristic and usually not very pronounced. More than one tumor in a
      single patient and also bone erosions caused by nodular tenosynovitis are rare
      occurrences. A case of a patient with multilocular occurrence of tenosynovitis is
      described here.

PMID- 1027663
TI  - A case report of symptomless carcinoma developing in a pulmonary cyst.

PMID- 1027664
TI  - Experimental study of kanamycin concentration in blood, cerebrospinal fluid and
      perilymph in rabbits.

PMID- 1027665
TI  - A study of acid-base balance of cerebrospinal fluid in man.

PMID- 1027666
TI  - A study of acid-base balance of CSF in man: "separated acidosis" in CSF in the
      case of brain abscess.

PMID- 1027667
TI  - A case of double inferior venae cavae.

PMID- 1027668
TI  - A case of cerebral abscess in a 2 month-old infant treated by a "perfusion
      method".

PMID- 1027669
TI  - A study of acid-base balance and gases of CSF and arterial blood in cases of
      intracranial aneurysm in connection with neurosurgical operation.

PMID- 1027670
TI  - Motivation through behavior modification, part 2: Evaluation.

PMID- 1027671
TI  - Spotlight on the staff. Maintenance.

PMID- 1027672
TI  - Nursing in a specialty facility.

PMID- 1027673
TI  - Treating the total patient.

PMID- 1027674
TI  - Management by persuasion: prescription for the modern healthcare institution.

PMID- 1027676
TI  - Spotlight on the staff: fiscal services.

PMID- 1027675
TI  - Motivation through behavior modification, part 1: The job contract.

PMID- 1027677
TI  - Management of nursing care. Quality assurance: staff evaluation and a
      retrospective audit system.

PMID- 1027678
TI  - Emergency medical technicians.

PMID- 1027679
TI  - Split-cost accounting: a more precise and equitable way to assign patient costs.

PMID- 1027681
TI  - U.S. using its clout to force revolution in blood banking.

PMID- 1027680
TI  - Japan II: Physicians prosper from volume, 3rd party fees.

PMID- 1027682
TI  - "...Nor any drop to drink".

PMID- 1027683
TI  - Reasons for "antibiotic failures".

PMID- 1027684
TI  - Managing neonatal infections.

PMID- 1027685
TI  - Pseudomonas in the hospital.

PMID- 1027686
TI  - A basic body plan.

PMID- 1027687
TI  - The case of the vesicocolic fistula.

PMID- 1027688
TI  - Heart disease in the elderly.

PMID- 1027689
TI  - Generic drugs and the future of therapy.

PMID- 1027690
TI  - Simultaneous multiple organ support.

PMID- 1027691
TI  - Organic brain syndromes in the aged.

PMID- 1027692
TI  - Esophageal reflux: new concepts in medical management.

PMID- 1027693
TI  - Bangladesh: a few healthy islands in a sea of misery.

PMID- 1027694
TI  - Lab utilization--the profit motive.

PMID- 1027695
TI  - Urinary infection screening in infants.

PMID- 1027696
TI  - Circadian systems in man and their implications.

PMID- 1027697
TI  - The case of the obstructed ureter.

PMID- 1027698
TI  - Current therapy of gout and hyperuricemia.

PMID- 1027699
TI  - Pneumonia syndromes in children.

PMID- 1027701
TI  - Zen and the art of getting into medical school.

PMID- 1027700
TI  - Ultrasonic echography in renal disease.

PMID- 1027702
TI  - National immunization for pandemic influenza.

PMID- 1027703
TI  - Transcutaneous, noninvasive monitoring of pO2.

PMID- 1027704
TI  - Arrhythmias and antiarrhythmic therapy in context.

PMID- 1027705
TI  - Very unnatural foods.

PMID- 1027706
TI  - Functional disorders in the elderly.

PMID- 1027707
TI  - "Cheno" therapy for gallstones: where the Cooperative Study now stands.

PMID- 1027708
TI  - Bureaucracy afloat on a "Dead Sea".

PMID- 1027709
TI  - Stroke in the geriatric patient.

PMID- 1027710
TI  - GI problems in children: I.

PMID- 1027711
TI  - Managing chemotherapy-induced bone marrow suppression in cancer.

PMID- 1027712
TI  - Thymic hormone activity and spontaneous autoimmunity in dwarf mice and their
      littermates.
AB  - Serum thymic hormone activity (TA) was determined in hereditary hypopituitary
      dwarf mice (dw/dw) and their littermates (+/dw or +/+). It was found to be very
      low in the dwarf animals in comparison to their littermates. At 14 weeks of age,
      the dwarf littermates exhibited significant glomerular lesions characterized by
      deposits of IgG, IgG1, IgG2, IgA, IgM and C3, which were augmented by thymectomy
      of adult females. In contrast, hypopituitary dwarf mice had minimal glomerular
      deposits of immunoglobulins. Unlike these animals, their littermates showed
      antinuclear antibodies (ANA) and anti-deoxyribonucleic acid (DNA) antibodies in
      their serum. The present findings are discussed in relation to recent hypotheses
      on: (1) the role of the hypophysis in thymus-dependent immunological functions;
      and (2) the significance of T-cell deficiency in the development of autoimmunity.

PMID- 1027713
TI  - Evidence for the genetic control of antibody affinity from breeding studies with
      inbred mouse strains producing high and low affinity antibody.
AB  - The amount (Abt) and relative affinity (KR) of antibody produced in response to
      protein antigens injected in saline has been measured in the parents, F1 hybrids
      and backcross offspring of inbred mice which produce high and low KR antibody to
      these antigens. The results obtained support the view that antibody affinity is
      under polygenic control. Furthermore, strain related variation in Abt is
      independent of KR and the breeding experiments indicate that these two parameters
      are under independent genetic control.

PMID- 1027714
TI  - Suppression of immune responsiveness by a submandibular salivary gland factor.
AB  - Both tissue extracts prepared from submandibular salivary glands of male mice and
      epidermal growth factor isolated from these glands depressed the delayed type
      hypersensitivity response to 2,4-dinitro-1-fluorobenzene in mice. Extirpation of
      the submandibular salivary glands from male mice did not alter the delayed type
      hypersensitivity response. The role of salivary gland factors, particularly
      epidermal growth factor, in influencing the immune response has been discussed.

PMID- 1027715
TI  - A phagocytosis-enhancing factor in human plasma.
AB  - A phagocytosis-enhancing factor (PEF) with the capacity to stimulate the
      ingestion of sensitized sheep erythrocytes by human polymorphonuclear and
      mononuclear leucocytes has been isolated from human plasma by chromatography on
      DEAE-cellulose and filtration on Sephadex G-150 and Sephadex G-100. PEF is a
      protein of approximately 70,000 molecular weight which is susceptible to
      inactivation by heating at 60 degrees or by tryptic digestion. PEF promotes
      phagocytosis of erythrocytes sensitized with intact 7S antibody or bearing the
      C3b complement fragment, but not of unsensitized erythrocytes or erythrocytes
      sensitized with 19S antibody. The specificity of PEF interaction with target
      erythrocytes and the persistence of its stimulatory effect after the target cells
      are washed suggest that it promotes phagocytosis by an action on the
      erythrocytes.

PMID- 1027716
TI  - A lipid chemotactic factor from anaerobic coryneform bacteria including
      Corynebacterium parvum with activity for macrophages and monocytes.
AB  - A lipid with chemoattractant (chemotactic) activity for mouse and guinea-pig
      macrophages and for human blood monocytes is released by anaerobic coryneform
      bacteria (including Corynebacterium parvum). The active lipid is associated with
      fibrillar structures which lie on the outside of the bacterial cell and are
      released spontaneously during growth. The lipid can also be extracted easily by a
      number of methods. The fibrils are loosely associated with a capsule-like
      structure composed largely of polysaccharide. Purification of the active lipid
      was achieved by chloroform-methanol extraction of the whole organisms yielding a
      chloroform-soluble fraction attracting mononuclear phagocytes at concentrations
      around 10 microgram/ml. The infra-red spectrum of this material showed lipid but
      no peptide or sugar. Thin-layer chromatography yielded twelve spots of which
      three had chemoattractant properties. The most active of these gave staining
      reactions consistent with the presence of phospholipid, the other two probably
      contained free fatty acids and triglycerides. Thin-layer electrophoresis also
      yielded an active phosphorus-containing spot. Saturated fatty acids of chain
      lengths found in the anaerobic coryne forms had weak monocyte-attractant
      activity. As the active material was progressively purified, its activity as a
      monocyte attractant weakened.

PMID- 1027717
TI  - Demonstration of thymus-independent immune system in Xenopus laevis. Response to
      polyvinylpyrrolidone.
AB  - Larvae of Xenopus laevis were thymectomized at stage 45 (4 days old), and raised
      beyond metamorphosis. Thymectomized toads, when injected with
      polyvinylpyrrolidone (PVP), produced the same titres of antibodies as non
      thymectomized animals, providing strong evidence that the thymus-independent
      immune response is present in this anuran. Antibodies were of exclusively high
      molecular weight, heat-stable, and 2-mercaptoethanol sensitive. After
      immunization, lymphoid accumulations were evident in the splenic white pulp of
      both thymectomized and non-thymectomized toads, but in the red pulp the
      accumulations were prominent only in non-thymectomized toads.

PMID- 1027718
TI  - Quantitative and qualitative effects of cyclophosphamide administration on
      circulating polymorphonuclear leucocytes.
AB  - The effect of cyclophosphamide (CY) on the absolute numbers and function of
      polymorphonuclear leucocytes (PMN) surviving in the circulation following either
      a single dose (100 mg/kg, i.p.) or daily administration (20 mg/kg, i.p., for 5
      days) was studied in the guinea-pig. The quantitative effect of CY on peripheral
      blood leucocytes was assessed by measuring the absolute numbers of neutrophils,
      lymphocytes, and monocytes daily for 5 days following the initial injection of
      CY. The qualitative effects of CY on PMN function were determined by measuring
      the ability of these cells to function as killer cells. The two functional assays
      employed were the PMN-mediated PHA-induced cellular cytotoxicity and antibody
      dependent cellular cytotoxicity (ADCC) assays against chicken erythrocyte
      targets. Both regimens of CY administration produced an equivalent degree of
      leukopenia 5 days after the initial injection with disproportionately severe
      neutropenia (less than 300 PMN/mm3). However, neither regimen of CY
      administration produced a significant decrease in cytotoxic effector function as
      measured through a wide range of effector to target cell ratios, PHA
      concentrations, and antiserum dilutions. These findings have clinical relevance
      in that they demonstrate the dichotomy between the quantitative and qualitative
      effects of (CY) on PMNs in that CY administration can dramatically decrease the
      absolute numbers of circulating polymorphonuclear leucocytes while leaving intact
      certain effector cell functional capabilities of those PMN surviving in the
      circulation during drug administration.

PMID- 1027719
TI  - Reaction of an activated complex of guinea-pig complement components, C56, with
      unsensitized erythrocytes and with erythrocytes carrying C3b molecule.
AB  - During the interaction of guinea-pig complement intermediate cells, EAC423, with
      guinea-pig C5 and C6, an activated complex of C5 and C6, C56, was demonstrated in
      the fluid phase of the reaction mixture. C56 also was eluted from EAC42356 which
      had been generated by the interaction of EAC423 with C5 and C6. Both preparations
      of C56 showed quite similar characteristics and were not distinguished from one
      another. Both were capable of reacting with unsensitized erythrocytes (E) in the
      presence of C7 to form EC567. Further, they were able to react with EAC43 in the
      absence of C7 to form EAC43568 but did react with EAC43 pretreated with C3b
      inactivator, dithiothreitol or N-bromosuccinimide. These results indicate that
      guinea-pig C56 generated on EAC423 has a tendency to dissociate into the fluid
      phase. Nevertheless, the dissociated C56 can bind again to intact C3b molecule on
      the cells. The ability of cell-bound C3b to combine with C56 may lead to
      localization of C56 to the cell membrane carrying C3b, resulting in acceleration
      of attachment of C567 to the membrane. This assumption could be supported by the
      finding that the replacement of E by EAC43 increased the susceptibility of the
      cells to lytic action of complement induced by cobra venom factor. Thus, a new
      function of cell-bound C3b as localizing C56 to the membrane of sensitized cells
      was indicated.

PMID- 1027720
TI  - Local immunity in the respiratory tract of the chicken. I. Transudation of
      circulating antibody in normal and virus-infected birds.
AB  - Three-week-old chickens were given sheep erythrocytes or bovine serum albumin
      intravenously. Seven days later their tears and saliva possessed low levels of
      antibody to those antigens. Concurrent infection with lentogenic Newcastle
      disease virus (NDV) caused a significant increase in transuded antibody in those
      fluids. In chickens with circulating antibody to NDV, induced by parenterally
      administered inactivated vaccine, respiratory infection with heterologous
      infectious bronchitis virus resulted in limited transudation of anti-NDV. In
      contrast, the tears, saliva and tracheal fluid of non-vaccinated chickens
      undergoing primary infection with NDV acquired considerable levels of specific
      anti-NDV. The difference between the two groups is attributed to locally
      synthesized antibody.

PMID- 1027721
TI  - Specific suppression of delayed hypersensitivity skin reactions to collagen in
      guinea-pigs after immunization with collagen and Freund's incomplete adjuvant.
AB  - Partial suppression of cutaneous delayed hypersensitivity reactions to collagen
      in guinea-pigs was induced by pre-immunization with collagen and FIA. This
      suppression is specific since: (a) pretreatment with OA and FIA or FIA alone did
      not cause suppression of skin reactions to collagen; (b) suppression was observed
      only if the collagen used for pretreatment was from the same species as that
      employed for sensitization for delayed hypersensitivity reactions; and (c)
      animals with depressed skin reactivity to collagen reacted normally to PPD. The
      suppression is not mediated by inducible, circulating antibodies to collagen
      since: (a) antibody titres measured by passive haemagglutination did not
      correlate with the degree of suppression; (b) suppression was observed with
      collagen in random coil conformation which sensitizes guinea-pigs for delayed
      hypersensitivity skin reaction but does not induce antibodies to denatured
      collagen; (c) best suppression was obtained if the animals were pretreated with
      collagen and FIA 3 days before the sensitizing injection; and (d) passively
      transferred antibody from animals with suppressed skin reactivity did not
      suppress skin reactivity of animals made hypersensitive to collagen by injection
      of collagen and FCA.

PMID- 1027722
TI  - Intracellular modifications induced in mouse submaxillary glands by antibodies
      directed against saliva.
AB  - The purpose of this paper is to investigate whether an antibody directed against
      the exocrine secretion, saliva, is able to induce a modification in vivo within
      the specific cells of the submaxillary glands which synthesize this secretion.
      The salivary antigens synthesized within the glandular acinar cells are secreted
      into their respective lumen and are not present in the general circulation or in
      the intercellular spaces of the gland. When heterologous anti-saliva antibodies
      are injected into mice, they induce marked lesions within the acinar cells of the
      submaxillary glands. When different antibodies recognizing different salivary
      components are injected, they all induce similar modifications; it is not yet
      possible to distinguish whether different cells are involved in the synthesis of
      the different salivary components. The lesions described seem specific since
      other organs studied, such as the pancreas and the stomach, are unaffected. The
      different possible mechanisms of this cytotoxic effect are discussed.

PMID- 1027723
TI  - Further characterization of IgA in chicken serum and secretions with evidence of
      a possible analogue of mammalian secretory component.
AB  - Immunochemical studies of the intestinal secretory immune system of the chicken
      have led to further characterization of IgA in bile, intestinal contents and
      serum. A component was detected in late Sephadex G-200 fractions of caecal and
      intestinal contents which showed partial identity with bile, intestinal and a
      high molecular weight fraction of serum IgA. This component showed similar
      sedimentation characteristics to bovine serum albumin in sucrose density
      gradients, a fast electrophoretic mobility on polyacrylamide gel and is a
      possible analogue of mammalian secretory component (SC). Fractionation of serum
      from birds affected with infectious synovitis revealed two moleculare classes of
      IgA. Comparative double diffusion studies produced a reaction of complete
      identity between bile IgA and high molecular weight serum IgA (15S) and partial
      identity with low molecular weight serum IgA (7S), suggesting a lack of an SC
      determinant on the latter. A spur of partial identity between 15S and 7S serum
      IgA was also observed. Although no direct structural homology with mammalian or
      human IgA could be demonstrated by immunological cross-reactivity, the
      similarities of molecular characteristics, particularly emphasized by the
      presence of a secretory component, favour a functional analogy between the
      secretory immune system of the fowl and mammalian species.

PMID- 1027724
TI  - Immune response in the garter snake (Thamnophis ordinoides).
AB  - Garter snakes (Thamnophis ordinoides) were immunized with hen egg albumin, human
      gamma-globulin and Keyhole limpet haemocyanin in Freund's adjuvant. Antibody was
      consistently detected by radioimmunoelectrophoresis and in three different gamma-
      and beta-globulin precipitin lines called IgM (approximately or equal to 20S), Ig
      1 (approximately or equal to 9S) and Ig-2 (approximately or equal to 8-5S). Early
      antibody (day 31 after immunization) was frequently Ig-M whereas Ig-2 and
      especially Ig-1 were detectable for the longest duration (992 days). After
      immunization with antigen in Freund's adjuvant, Ig-1 serum concentration showed
      the greatest increase, from almost undetectable levels to the most prominent
      immunoglobulin in immune serum.

PMID- 1027725
TI  - Studies on the role of suppressor cells in specific unresponsiveness to DNCB.
AB  - Lymph nodes--and to a lesser extent spleen cells--from guinea-pigs tolerant to
      DNCB contact sensitivity, when injected into normal syngeneic guinea-pigs,
      decrease the ability of the recipients to become sensitized to contact with DNCB.
      The difference between the complete tolerance transferred by parabiosis with
      tolerant partners and the partial tolerance induced by transfer of tolerant cells
      can be explained by the different numbers of cells homing in the recipients. The
      tolergen does not play any role in the transfer of tolerance.

PMID- 1027726
TI  - Specialized structure and metabolic activities of high endothelial venules in rat
      lymphatic tissues.
AB  - Microscopic, histochemical and ultrastructural techniques were used to define
      characteristics of high endothelial venules (HEV) in rat lymphatic tissues. This
      endothelium contained acetyl esterase and acid hydrolase activities which were
      not altered by lymphocyte depletion. No immunoglobulins were detected on luminal
      surfaces of HEV by fluorescent antibody staining. Only minor structural
      differences were seen between HEV within lymph nodes and Peyer's patches. At both
      sites, high endothelial cells were linked together by macular junctional
      complexes and interlocking basal foot processes. Endothelial cell cytoplasm
      moulded about surfaces of lymphocytes migrating through the venular wall, and
      flocculant deposits of basement membrane formed over lymphocytes penetrating the
      basal lamina. The endothelium was ensheathed by three to five layers of
      overlapping reticular cell plates and connective tissue. Each plate was linked to
      the reticular meshwork of the node by collagen bundles and anchoring filaments
      which inserted into the plate's external limiting membrane. This permitted
      individual paltes to separate or approximate each other as tissue and
      intravascular pressure varied, and lymphocytes moved across the sheath by
      insinuating themselves into gaps between overlapping plates. This composite
      structure of the HEV wall appeared to facilitate lymphocyte entry into the node
      and minimized vascular leakge.

PMID- 1027727
TI  - The nature of the local immune system of the bovine small intestine.
AB  - In an examination of the immunoglobulins of the small intestine of calve, IgG1
      was the major immunoglobulin in the secretions, and IgA was present in smaller
      amounts. Immunohistochemical studies showed few IgA containing plasma cells but
      many cells that stained with anti-IgG antiserum. Histological evidence of
      transport of IgG1 across the crypt epithelial cell was found. Studies with 125I
      labelled IgG1 indicated that a significant proportion of IgG1 in the intestine
      originated in serum.

PMID- 1027728
TI  - Requirements of buffalo spermatozoa under storage.

PMID- 1027729
TI  - Preservation of Jersey bull semen at ambient temperature in Russian dilutor.

PMID- 1027730
TI  - Effect of certain dilutors on the morphology of ram spermatozoa on preservation
      at 5 degrees C.

PMID- 1027731
TI  - The circadian variations of the rates of excretion of urinary electrolytes and of
      deep body temperature.
AB  - 53 apparently healthy subjects were studied for control spans of between 60 and
      184 hours while they followed a regular pattern of meals, ambulance and sleep
      before experiments on altered time schedules. Urine was collected and deep body
      temperature was measured every 2 hours while they were awake, and in some rectal
      temperature was also recorded during sleep. Urine was analysed for sodium,
      potassium, chloride, phosphate and creatinine and in 26 subjects also for calcium
      and uric acid. The rhythms of temperature, urine flow, and rate of excretion of
      each urinary solute, are presented as consinors. The two rhythms most closely
      linked were of excretion of chloride and sodium; the choloride acrophase led the
      sodium acrophase by one a half hours.

PMID- 1027732
TI  - Effects of meal timing on circadian rhythms in 9 physiologic variables of young
      healthy but obese women on a calorie restricted diet.

PMID- 1027733
TI  - Two biological rhythms of perception distinguishing between intact and relatively
      damaged brain function in man.
AB  - A simple test of perception, the Critical Flicker Fusion threshold (CFF) was
      given successively for 20 mins. to 69 healthy subjects aged 7-63 and to 53
      comparable neuropsychiatric patients. The latter could be divided into a
      functionally sick group and a group with brain damage. Auto-correlation analysis
      revealed significant sine-wave cycles of amplitude and ultradian frequency for
      the CFF mean scores and the CFF "Scatter* scores. Both cycles of recurrence
      showed frequencies which distinguished significantly between the total healthy
      subjects and the patients. Further analysis showed no difference between controls
      and emotionally sick patients (i.e. those with sociopathy, schizophrenia and
      manic depressive psychosis) but there was a highly significant difference between
      these three groups and patients with relatively damaged C.N.S. (i.e. those with
      mental deficiency, organic brain syndrome and organic dementia). Even among the
      control group a progressive increase in frequency of these perceptual cycles
      occurred with advancing age. These CFF results point to the existence of a cycle
      of perceptual acuity and another of vigilance in the organism. Both appear to
      relate to the neural integrity of the C.N.S.

PMID- 1027734
TI  - A chronobiological investigation of fitness for work in women on a 220 cal 24 h
      protein diet.
AB  - In a group of nine healthy but obese women a set of tests were used to estimate
      several physiological and psycho-physiological variables: self-rating of hunger,
      mood and physical vigor, self-recording of grip-strength, muscular fatigue test,
      eye-hand skill, tempo, etc. Measurements were performed every 6-hours, at fixed
      times, during 24-hours, once a week, before (non-restricted spontaneous food
      intake) and for three weeks on a 220 cal. special protein diet (calcium
      caseinate: 55g, associated with potassium salts, water and vitamins). Findings
      relating to the metabolic and hormonal variables while on this diet have already
      been reported: (a) The diet does not alter the circadian acrophase (peak) of the
      variables and (b) two distinct metabolic steps occur: first a peak of
      gluconeogenesis and second, a phase when ketone bodies and fatty acids are used
      almost exclusively as source of fuel. The present findings show that so long as
      nitrogen remains in balance this restricted diet (a) does not change the grip
      strength and the muscular fatigue test; (b) does not alter the mood, the physical
      vigor etc. and (c) induces a statistically significant fall in "hunger" (self
      rating method). We conclude that this low protein diet is compatible with non
      strenuous work.

PMID- 1027735
TI  - The chronomutagenic effect of deuterium oxide on the period and entrainment of a
      biological rhythm. II. The reestablishment of lost entrainment by artificial LD
      cycles.
AB  - Mice caused to ingest 25% or 30% deuterium oxide could no longer be entrained to
      a 12:12 light-dark cycle. Reentrainment could be established by artificially
      lengthening the light-dark cycle from a natural 24-hours one, to LD 13:13 or
      14:14. It is noted that the relationship between biological rhythms and the
      ambient LD cycle is strikingly similar to that between coupled unidirectional
      physical oscillators. It is concluded that while the similarity between the
      responses of a great many organismic rhythms to deuterium oxide administration
      suggests that the biological clocks of all organisms are very similar, if not the
      same, a substance with more specificity to key biological processes than D2O will
      be required to eventually elucidate the escapement mechanism of the enigmatic
      living clock.

PMID- 1027736
TI  - Acetabulaira mediterranea: circadian rhythms of photosynthesis and associated
      changes in molecular structure of the thylakoid membranes.
AB  - Acetabularia mediterranea algae, grown in three different light-dark regimes,
      were frozen in liquid nitrogen at c.t.(1) 0 and c.t. 6 and a record made of 77
      degrees K fluorescence emission spectra of their chloroplasts. Algae grown under
      LD cycles exhibited a clear circadian rhythm of oxygen production. The low
      temperature fluorescence emission spectrum at c.t.0 was different from that at
      c.t.6 and this difference was increased by submitting the algae to successive
      "freeze-thaw" treatment. Similar results were obtained in DD, and the
      photosynthesis rhythm remained fully expressed. Algae grown in LL, where no
      rhythm of photosynthesis could be detected in the samples because there is a
      great individual variability in period lenght under these conditions, exhibited a
      similar difference in their low temperature flourescence emission spectra between
      c.t.0 and c.t.6. We conclude that the circadian rhythm in low-temperature
      fluorescence emission of the chloroplasts in Acetabularia is related to the
      circadian rhythm in photosynthesis.

PMID- 1027737
TI  - Irradiation-induced changes in circadian DDT-susceptibility and metabolic rhythms
      in the housefly.
AB  - The diel pattern of susceptibility to DDT of houseflies, reared under LD 14 : 10,
      was shown to be affected by 10 Krads of gamma radiation administered at the pupal
      stage. An additional peak in susceptibility of the flies to DDT corresponded to
      the time of irradiation of the pupae. Irradiated flies had higher general LD50
      values than untreated flies. Flies reared in darkness demonstrated no discernable
      group rhythm apart from an altered susceptibility at the pupal irradiation time.
      Respiration rates of irradiated flies were slightly lower than the control flies
      and did not change at the time of irradiation. Groups of flies reared in darkness
      have no significant respiration rhythm.

PMID- 1027738
TI  - A self-assessment questionnaire to determine morningness-eveningness in human
      circadian rhythms.
AB  - An English language self-assessment Morningness-Eveningness questionnaire is
      presented and evaluated against individual differences in the circadian vatiation
      of oral temperature. 48 subjects falling into Morning, Evening and Intermediate
      type categories regularly took their temperature. Circadian peak time were
      identified from the smoothed temperature curves of each subject. Results showed
      that Morning types and a significantly earlier peak time than Evening types and
      tended to have a higher daytime temperature and lower post peak temperature. The
      Intermediate type had temperatures between those of the other groups. Although no
      significant differences in sleep lengths were found between the three types,
      Morning types retired and arose significantly earlier than Evening types. Whilst
      these time significatly correlated with peak time, the questionnaire showed a
      higher peak time correlation. Although sleep habits are an important determinant
      of peak time there are other contibutory factors, and these appear to be partly
      covered by the questionnaire. Although the questionnaire appears to be valid,
      further evaluation using a wider subject population is required.

PMID- 1027739
TI  - Disaster in plastic. The vinyl chloride coverup.

PMID- 1027741
TI  - Ford-Carter checklist on health issues.

PMID- 1027742
TI  - Notes from NYC's fiscal crisis: North Central Bronx Hospital fiasco.

PMID- 1027743
TI  - On putrefactions and floatations of dead bodies under water (supplement).

PMID- 1027744
TI  - An autopsy case of sacrococcygeal teratoma with overgrowth of immature tissue.

PMID- 1027745
TI  - Platelet migration inhibition test for platelet antibodies...parameters and
      simplified methodology.

PMID- 1027746
TI  - The impaired insulin release in response to oral glucose in patients with gastric
      ulcer.

PMID- 1027747
TI  - Protection against alloxan inhibition of insulin release by glucose, cytochalasin
      B and diphenylhydantoin.

PMID- 1027748
TI  - [Various aspects of the rehabilitation of the hemiplegic patient].

PMID- 1027749
TI  - [The effect of local heating on the uptake of 99m-technetium labeled
      pyrophosphate of tin in humans].

PMID- 1027750
TI  - [Yersinia enterocolitica in rheumatologic practice (author's transl)].

PMID- 1027751
TI  - [A rare form of cancer of the common bile duct: papillary epithelioma. Report of
      4 cases].
AB  - Papillary carcinoma is rare as it represents only 5 p. cent of carcinomas of the
      common bile duct. The authors report 4 cases and emphasize the special
      characteristics of this carcinoma. The long prodromal phase, dominated by attacks
      of cholangitis and the incomplete appearance of the jaundice when fully
      constituted. It affects mainly the common bile duct and has, on microscopy, a
      villous appearance. Its papillary structure consists of fine coalescent fringes
      producing a typical glandular appearance. Finally, it evolves very little,
      therefore there is a good hope of survival even after palliative treatment.

PMID- 1027752
TI  - [Fractures of the lower extremity of the femur. Therapeutic indications and
      results of a series of 86 fractures].
AB  - The authors report 76 recent fractures of the lower femoral end. The types of
      fractures, the treatment and the results are analyzed. Kuntscher's close wound
      intramedullary nailing with reaming should be employed for transversal supra
      condylar fractures and classical osteosynthesis for other cases.

PMID- 1027753
TI  - [Palilloma and papillary tumor of the gallbladder].
AB  - Frequently confused with adenomas or pseudopolyps of the gall bladder, papillomas
      are rare tumours defined as vegetations covered with an epithelium of gall
      bladder type in the centre of which is a thin connective tissue axis. They are
      usually recognised on lyon histological examination of the operative specimen.
      The uncertainty concerning their course makes them a potentially malignant lesion
      as shown by the two cases reported here including one personal case concerning a
      carcinoma situated close to a benign papillomatous lesion. The frequent
      coexistence with lithiasis which may induce their malignant transformation
      reinforces the indications for surgery for gall stones.

PMID- 1027754
TI  - [Rupture of the subclavian artery. Apropos of a case].
AB  - The authors report a typical case of rupture of the sub-clavian artery in closed
      trauma of the shoulder and review the world literature. The pathology of this
      lesion is described and its mechanism studied, it seems to be due to an acute
      encounter between the artery and the scalenus anterior.

PMID- 1027755
TI  - [Barium granuloma of the rectum].
AB  - The authors report a case of barium granuloma of the rectum. This complication of
      barium enema is exceptional. During enema, the cannula may ulcerate the mucosa
      which is blown up secondarily by the barium. Clinically, the granuloma presents
      like a hard polyp which is suggestive in certain cases of a malignant tumour. The
      precise diagnosis is made by careful examination of the abdominal films before
      administration of barium taking in the whole of the pelvis.

PMID- 1027756
TI  - [Treatment of bone metastasis].

PMID- 1027757
TI  - [Ureter and Wertheim's operation].
AB  - The surgery for carcinoma of the uterine cervix combined with radiotherapy, as
      carried out at present, includes a definite risk for the urinary tract. Not so
      much the immediate functional disorders, which always recede, except in rare
      cases of fibrous retracted bladder, but the lesions which occur in several
      varieties lead one to re-implant immediately the ureter. Fistulae and early
      stenosis (16 out of 1,500) should be treated in the same way. These late
      complications, such as obstruction (12 out of 1,500) raise de problem of their
      etiology. Usually they are due to recurrent carcinoma (9 out of 12), rarely due
      to pelvic fibrosis (3 out of 12). It is rare then for re-implantation to be
      possible. There remains either nephrectomy which is the simplest solution, or an
      urinary by-pass operation either using an ileal bladder or as a palliative
      measure, using a silastic prosthesis. Finally, the risk of advanced carconoma is
      without remedy, abstention from surgery may then be justified but one should, as
      far as possible, attempt to prevent these complications both from the surgical
      technical point of view and from the point of view of irradiation dosage.

PMID- 1027758
TI  - [Transit-slowing anastomosis by 180 degree axial rotation of the upper intestinal
      segment after massive resection of the small intestine. Preliminary note on an
      experimental study in the adult dog].
AB  - After massive resection of 85 p. cent of the small intestine in the dog, there
      occurs diarrhoea and malabsorption. These consequences may be palliated by an
      oblique end-to-end anastomosis with 180 rotation on the intestinal axis of the
      jejunal sugment above in relation to the ileal segment below. The authors noted
      slowing of the transit in the 10 operated dogs. The experimental conditions and
      the results obtained suggest that the technic may be applicable in man.

PMID- 1027759
TI  - Hypnosis therapy for ciliary spasm.

PMID- 1027760
TI  - Culture and the development of vision.
AB  - Given Chinese ethnographic data, a model of a style of visual performance was
      predicted. The prediction was that the style would be "inwardizing". Inwardizing
      was related to individual styles of social behavior as observed in optometric
      offices. A complete 21-point optometric examination was performed on Chinese
      subjects and the results were compared to a control group of American subjects.
      Throughout the optometric examination the Chinese subjects displayed the
      predicted pattern of inwardizing visual performance. That physiologically
      measurable patterns of visual performance could be predicted on the basis of
      ethnographic data gives experimental support to the anthropological assumption of
      reciprocity between biology and culture. The discovery of a culturally determined
      pattern of visual performance beyond the work already done with various isolated
      refractive conditions and the observed relationship of this to patterns of social
      behavior pose interesting tasks for anthropology, optometry and other
      professions. First, there is need for further investigation of 1) the role of
      culture in determining visual performance and 2) the relationship of visual
      performance patterns to social behavior, beyond that which has already been done,
      for example, with myopia and hyperopia. Then there is need to incorporate these
      new areas of knowledge into all fields dealing with human behavior.

PMID- 1027761
TI  - Systemic arterial blood pressure and its relevance to optometric practice.
AB  - The measurement of systemic blood pressure is a very significant detection test
      that can provide a great deal of information for the optometrist. The blood
      pressure readings can be critical in aiding the practitioner's evaluation of both
      the patient's visual health and related systemic condition and in indicating the
      possible need for referral. This paper presents a general survey of the benefits
      blood pressure measurements can provide in the optometric practice.

PMID- 1027762
TI  - A new technique for detection of early central serous retinopathy.

PMID- 1027763
TI  - Use of a pupillary lens in aphakia.

PMID- 1027764
TI  - Clinical manifestations of visual information processing: part I.
AB  - This paper discusses three aspects of visual information processing and their
      significance to clinical optometric practice. It analyzes the factors involved in
      central-peripheral organization, pictorial-linguistic interaction and total
      versus partial utilization os sensorimotor information as they relate to
      perceptual style and visual function. It emphasizes these factors as possibly
      being the commonalities behind many of the divergent yet generally successful
      theoretical frameworks and techniques utilized in optometric diagnosis and
      therapy.

PMID- 1027765
TI  - Impact testing of ophthalmic lenses: stress distribution and the "search" theory.
AB  - Elementary concepts in fracture mechanics, stress analysis, and impact are
      discussed as they pertain to fracture of lenses in drop ball testing. Quasi
      static estimates for stress distributions during impact are obtained. These
      profiles show a sharp peak in the tensile stress under the impact point.
      Identical groups of lenses were impact tested in two different modes: 1) 25
      impacts at a single spot on the lens, 2) 1 impact at each of 25 different spots.
      Much more breakage was observed in the latter group. Both the experimental and
      analytical considerations lend support to the "search" theory of drop ball
      testing--fracture occurs when the ball strikes a weak spot (where there exists a
      sufficiently severe flaw) on the lens. Lenses which pass an impact test may well
      have dangerous flaws away from the impact point.

PMID- 1027767
TI  - Ethics and the consumer.

PMID- 1027766
TI  - Should there be a restriction of optometric treatment?
AB  - The restriction of optometric services in third party payment programs is of
      considerable concern to the profession. Limitations placed on the type and amount
      of lens prescriptions which can be provided is not in the best interest of the
      patient. Those outside the profession of optometry must be made aware of the
      significance of ophthalmic lens prescriptions in terms of total visual
      performance rather than mere correction of "significant" refractive errors.

PMID- 1027768
TI  - Research in orthokeratology. Part III: results and observations.
AB  - The effects of contact lenses, fitted by defined conventional and
      orthokeratological techniques, are given and compared to a group of non-contact
      lens wearers. Data presented include changes in corneal curvature, topography,
      refraction and astigmatism. General trends and variability of data are discussed
      in conjunction with pertinent clinical observations for the three test groups.

PMID- 1027769
TI  - The interpretation of systemic arterial blood pressure. Part III: hypertension
      retinopathy.
AB  - Systemic blood pressure is a vital sign and fundamental variable and as such the
      areas of its involvement in all individuals are indeed multifaceted. The purpose
      of this paper is to discuss the interpretation of systemic blood pressure
      readings as they specifically relate to a detailed analysis of hypertensive
      retinopathy.

PMID- 1027770
TI  - Tear breakup time and the Schirmer tear test.
AB  - An analysis of tear film breakup time (BUT) and the Schirmer tear test in 40
      optometric students demonstrated that BUT cannot be used as a tear quantity
      indicator.

PMID- 1027771
TI  - A descriptive epidemiological study of optometry services in the Birmingham
      Veterans Administration Hospital.
AB  - The Optometry Service in the Birmingham Veterans Administration Hospital has been
      delivering comprehensive vision care to outpatients and inpatients for almost 3
      years. The veteran population receiving care and the optometric services provi4ed
      are described.

PMID- 1027772
TI  - The rural optometrist: who and why?
AB  - A first step toward the goal of better optometric manpower distribution is the
      identification of variables associated with the optometrist's choice of practice
      location. This study focuses on the optometrist who chooses a rural practice
      location and on ways in which the rural optometrist differs from the non-rural
      optometrist. One hundred sixty optometrists practicing in rural locations in ten
      states answered questions about their background, mode of optometric practice,
      attitude toward the environment, interests, and personality traits. Rural
      optometrists were found to differ from other optometrists in their rural origin,
      their strong liking for the people and life style of the rural community, and
      their interest in outdoor pursuits. Community recognition as a health
      professional, rapid practice growth, professional independence, and the
      opportunity for community leadership were seen by the rural optometrist as major
      advantages of rural optometric practice.

PMID- 1027773
TI  - A preliminary report of posterior corneal changes occurring in SOFLENS wearers.

PMID- 1027774
TI  - The fear of extinction.

PMID- 1027776
TI  - HMO--here's what it's all about.

PMID- 1027775
TI  - Optometry in 1976--like the old country in 1948.

PMID- 1027777
TI  - Health planning and resources development: an opportunity for optometry.
AB  - The American Optometric Association views the goal of the National Health
      Planning and Resources Development Act of 1974, as the promotion of physical,
      emotional and environmental health for all. The National Health Planning and
      Resources Development Act will work towards this goal by identifying problems,
      preparing reports and studies and developing recommendations for implementation
      directed toward solving the problems. These functions will be carried out in
      collaboration with private and governmental individuals and organizations
      concerned with health care services. Only through this coordinated effort will
      success be achieved.

PMID- 1027778
TI  - Optometry and NHI--where are we going.
AB  - The author reviews and estimates the overall trend toward some form of national
      health entitlement against a background of optometry's position on this issue. He
      summarizes how optometric services are included in most major NHI bills, and
      explains the relationship to NHI of the National Health Planning and Resources
      Development Act of 1974. Stressed are the needs for optometry to more accurately
      describe its own role and to continue active interest in the NHI issue.

PMID- 1027779
TI  - Optometry and the military.
AB  - This article comments on several of the major issues facing military optometry
      which were aired earlier this year at the AOA Federal Service Optometry Seminar.
      Among these issues, all of which influence recruitment and retention of optometry
      officers, are constructive credit, bonus and incentive pay, promotion policies,
      and optimum scope of care. Dr. Turner emphasizes that solutions to these problem
      areas depend not only upon AOA actions but also personal efforts and
      professionalism of military OD's.

PMID- 1027780
TI  - Professional participation in HMO's.
AB  - As HMO's spring up throughout the country, a conflict between state and federal
      laws becomes evident. The traditional standards of practice by which the solo
      practitioner abides may no longer be enforceable against those physicians,
      dentists, and optometrists working in HMO's.

PMID- 1027781
TI  - Comprehensive vision care: a model.
AB  - This paper suggests a model for the practice of vision care in which the
      optometrist and ophthalmologist are each used to maximum advantage. It is
      demonstrated how the present antagonism between the two fields can be removed
      with a resultant enhancement of the practice of both optometry and ophthalmology.
      The natural outcome of the new relationship will be better vision care for the
      public.

PMID- 1027782
TI  - Rationalizing the delivery of eye care--part I.
AB  - The often proclaimed health care crisis has led to a variety of efforts to
      reorganize and rationalize the existing health care system. One such effort has
      been to develop a conceptual model for the delivery of personal health services
      in which the region is the fundamental planning unit and levels of care form its
      organizational framework. Three levels of care are defined--primary, secondary,
      and tertiary--each level being based on a combination of the frequency with which
      a service is needed and its professional and technical sophistication. The
      regionalization of health services would serve to "achieve a balance between the
      public's request for decentralized resources and the centralization required so
      that they may be used efficiently."

PMID- 1027783
TI  - Optometric manpower development and utilization: a look toward the future.
AB  - This paper attempts to discuss in detail the rise in demand for optometric
      services and the manpower problems of the future. A proposal for the rational
      future development of optometric manpower has been made. Hopefully optometry will
      be able to consider its future development and scope of practice, and the types
      of changes to be made as the profession prepares for its increasing role in
      providing quality vision care to all Americans.

PMID- 1027784
TI  - Malignant hypertension.

PMID- 1027785
TI  - The contact lens of the future.

PMID- 1027786
TI  - Contact lenses in review: 1975.

PMID- 1027787
TI  - The philosophy of contact lens fitting--updated.

PMID- 1027788
TI  - The physiology of contact lens systems.

PMID- 1027789
TI  - Importance of oxygen in contact lens wear.

PMID- 1027790
TI  - Psychology and contact lenses.

PMID- 1027792
TI  - The effect of contact lenses on visual function.

PMID- 1027791
TI  - Corneal edema from hard and hydrogel contact lenses.

PMID- 1027793
TI  - Refitting the contact lens patient.

PMID- 1027794
TI  - Continuous wear of contact lenses.

PMID- 1027796
TI  - Low vision care and contact lenses.

PMID- 1027795
TI  - Soft lenses in anterior segment pathology.

PMID- 1027797
TI  - Contact lens materials--an overview.

PMID- 1027798
TI  - PMMA material.

PMID- 1027799
TI  - The Rynco (TM) RX-56 lens.

PMID- 1027800
TI  - The Bausch & Lomb SOFLENS (R) contact lens.

PMID- 1027802
TI  - The Softcon (TM) lens...an overview.

PMID- 1027801
TI  - The Aquaflex hydrophilic contact lens.

PMID- 1027803
TI  - The Durasoft (TM) contact lens.

PMID- 1027804
TI  - Development of the GELFLEX contact lens.

PMID- 1027805
TI  - Hydrocurve.

PMID- 1027806
TI  - Sophistication and contact lenses.

PMID- 1027807
TI  - Thin lens rationale projected.

PMID- 1027808
TI  - Ballasted cylindrical lenses.

PMID- 1027810
TI  - The control of presbyopia without bifocals.

PMID- 1027809
TI  - Bifocal contact lenses--principles of fitting.

PMID- 1027811
TI  - Scleral lenses.

PMID- 1027812
TI  - Aspheric and ellipsoidal corneal lenses.

PMID- 1027814
TI  - Fitting techniques for the hydrophilic lens.

PMID- 1027813
TI  - A personal overview of toroidal contact lenses.

PMID- 1027815
TI  - Standardizing lens position and fit.

PMID- 1027816
TI  - Stability--a prerequisite for fitting success.

PMID- 1027818
TI  - Contact lens center thickness.

PMID- 1027817
TI  - Fluorescein: pattern analysis and staining.

PMID- 1027819
TI  - The visual Rx.

PMID- 1027820
TI  - Dimensional stability of contact lenses--update 1976.

PMID- 1027821
TI  - Contact lens inspection.

PMID- 1027822
TI  - Biomicroscopy for contact lens practice.

PMID- 1027823
TI  - Venting and fenestration.

PMID- 1027824
TI  - Lens size consideration, hard and soft lenses.

PMID- 1027825
TI  - Centering the contact lens--rigid and flexible.

PMID- 1027826
TI  - Symptomatology.

PMID- 1027827
TI  - Corneal insult and staining--hard lenses.

PMID- 1027828
TI  - Flare.

PMID- 1027830
TI  - Blinking and corneal lens wear.

PMID- 1027829
TI  - Spectacle blur.

PMID- 1027831
TI  - Corneal curvature: patterns of change after wearing contact lenses.

PMID- 1027832
TI  - Long term effects of wearing hard lenses.

PMID- 1027833
TI  - Poor visual acuity, hard and soft lenses.

PMID- 1027835
TI  - Spherical aberration problems.

PMID- 1027834
TI  - Arcuate staining.

PMID- 1027836
TI  - Patient indoctrination.

PMID- 1027837
TI  - Contact lens solutions.

PMID- 1027838
TI  - Contact lens practice management.

PMID- 1027839
TI  - The use of assistants in contact lens practice.

PMID- 1027840
TI  - Contact lenses and aphakia.

PMID- 1027841
TI  - Further developments in keratoconus.

PMID- 1027842
TI  - Orthokeratology.

PMID- 1027844
TI  - Hypnosis in contact lens fitting.

PMID- 1027843
TI  - Contact lens use for sports.

PMID- 1027845
TI  - Optometric technicians.

PMID- 1027846
TI  - A case study.

PMID- 1027847
TI  - The "eyeglass" profession.

PMID- 1027848
TI  - A retrospective analysis of the systolic BP/IOP ratio in glaucoma screening.
AB  - It has been postulated that the BP/IOP ratio is more predictive of glaucoma than
      is tonometry alone. An analysis of clinical data from 128 glaucoma patients and
      115 normals yields a sensitivity of 80%. Specificity of 86% and relative risk
      ratio of 22 for this screening test. Evidence of the existence of a dose-response
      relationship is also found.

PMID- 1027849
TI  - Optometry and genetic counseling: the first lines of defense against blindness.
AB  - Genetic diseases may be present at birth or may be manifested later in life. The
      best preventative measure for either type is early referral of the affected
      family for genetic counseling. Since several genetic disorders include ocular
      complications either primarily or secondarily, optometrists are likely to
      encounter some of these disorders. If the family is unaware of the hereditary
      pattern, they should be referred to a geneticist to be advised of the risk rates
      for having future children affected. A partial listing of the counseling centers
      throughout the United States is provided.

PMID- 1027850
TI  - Suggested criteria for vision classification on the AAMD adaptive behavior scale.
AB  - The AAMD Adaptive Behavior Scale for Children and Adults is an instrument
      designed to assess the degree to which an individual has adapted to his
      environment. While one item of the scale refers to vision, no criteria have been
      established to indicate degree of vision impairment on such a scale. Such
      criteria are suggested including a supplement which describes other visual
      functions. A method of assessing visual acuity in non-verbal or uncooperative
      patients is given.

PMID- 1027851
TI  - Vision anomalies of Indian school children: the Lame Deer study.
AB  - The occurrence of vision anomalies among American Indian school children is
      measured for an entire school population, according to grade (pre-kindergarten
      through 12). The anomalies are identified, classified in three major groups
      (myopes, astigmats, all other), and each group is compared to Caucasian school
      children. Some conclusions and recommendations are made concerning the vision
      care needs of Amerind school children.

PMID- 1027852
TI  - Rationalizing the delivery of eye care--part II.
AB  - The provision of eye care within the previously described regional model requires
      that resources be distributed in a rational manner. In a levels of care approach
      those eye care services that would meet most of the people's needs most of the
      time would be provided at the primary level, on an ambulatory basis. At the
      secondary level those more specialized services such as glaucoma surgery would be
      provided, usually at the community hospital setting. At the tertiary level those
      superspecialized services requiring the resources of a major medical center would
      be provided. Such a system of eye care would require changes in the role and
      responsibility of both optometrists and ophthalmologists.

PMID- 1027853
TI  - Clinical manifestations of visual information processing: part II.

PMID- 1027854
TI  - A rational approach to license drivers using bioptic telescopes.
AB  - A great deal of interest and controversy has arisen about the ability of persons
      with reduced vision driving with bioptic telescopes. This article is the author's
      approach to the public. The author has been fitting drivers with bioptic lenses
      for approximately ten years.

PMID- 1027855
TI  - Marathon running and vision.
AB  - Sixteen optometric tests were administered to 29 athletes prior to and following
      their running the 1974 26-mile B.A.A. Boston Marathon. The tests included
      amplitude of accommodation, near point of convergence, stereopsis, depth
      perception, near phorias, ACA, near ductions, peripheral fields, and suppression.
      It appears that the systemic fatigue did not significantly affect the test values
      and it is reasonable to assume similar findings for other forms of athletics.
      While few optometrists' or ophthalmologists' patients are marathon runners, this
      study's findings may be extrapolatable to more common conditions.

PMID- 1027856
TI  - The $10,000 fee--almost.

PMID- 1027857
TI  - The eye that wouldn't quit.

PMID- 1027858
TI  - A changing role for optometry.

PMID- 1027859
TI  - Classification of visual performance.

PMID- 1027860
TI  - Advertising of prices for eyeglasses.

PMID- 1027861
TI  - Photochromics and occupational safety.

PMID- 1027862
TI  - The measurement of systemic arterial blood pressure.
AB  - The measurement of blood pressure, sphygmomanometry, can provide much significant
      information for the optometrist's evaluation of his patient's ocular and related
      systemic conditions when the principles involved are understood and skill in its
      measurement is achieved. This paper will discuss the procedural details of blood
      pressure measurement.

PMID- 1027863
TI  - Diagnosis: a word misused.

PMID- 1027864
TI  - The effect of aging on the impact resistance of heat tempered lenses.
AB  - Stock sperocylindrical lenses (125) with approximately 2.2-mm center thickness
      were bevel-edged to 48-mm size in the S-10 standard military lens shape. One time
      each, 25 lenses were drop balled directly after heat treatment; 25 after 3
      months;25 after 6 months; 25 after 9 months; and the final 25 after 1 year.
      Comparing these samples against each other showed no statistical difference in
      breakage. All the surviving lenses were then drop balled repeatedly until broken
      or 25 impacts had been made. After 25 hits, 76.8% of the lenses did not break.
      There was no statistical difference in breakage when these results were compared
      with 125 heat-treated lenses of similar specifications that were drop balled for
      25 trials, if not broken sooner, just after routine heat-treatment processing.
      Lenses of approximately 3.0-mm center thickness, with other aspects the same,
      were also treated. The effect of drop balling nonheat-tempered lenses of
      dimensions similar to the aged lenses was studied; the first drop had a casualty
      rate of 75%, and no lens survived more than 8 impacts.

PMID- 1027865
TI  - The role of edge failures in impact testing of ophthalmic lenses.
AB  - The role of edge mode failures in drop ball testing of ophthalmic lenses was
      investigated. The relative effects of lens shape and type of edging operation
      were determined by comparing the impact performance of groups of lenses. Strain
      gages were mounted on the edges of several lenses to determine the applied
      tensile stresses. The results were reviewed in the context of the flaw
      distribution theory. As expected, more breadage was observed for those edging
      processes which introduce more severe flaws and for those lens shapes for which
      higher edge stresses were measured. It was also observed that the search theory
      of impact testing is applicable for edge flaws as well as for surface flaws (a
      lens sustains many impacts before it fractures; the ball is searching for a weak
      spot on the lens).

PMID- 1027866
TI  - A model study of facial injury caused by impact while wearing an ophthalmic
      frame.
AB  - Damage to facial tissue caused by an ophthalmic frame when there is impact to the
      face was studied by means of a paraffin-covered mannequin head. Under mild
      conditions of impact it was easily observed that metal frames and metal
      components do more tissue damage than is done by a zylframe. A series of the
      commonly dispensed frames was compared for facial injury potential caused by
      impact to the face.

PMID- 1027867
TI  - A study of applicants to colleges of optometry in the U.S.
AB  - A statistical summary of numbers of applicants and applications to U.S. colleges
      of optometry, dentistry, and medicine is presented for the six academic years,
      1969-70 through 1974-75. Attention is drawn to changes during the five-year
      interval in numbers of (a) professional schools, (b) total applicants, (c) total
      applications, (d) applicants accepted, (e) applicants per acceptance, (f) percent
      of applicants accepted, and (g) applications per individual. Absolute numbers are
      listed in tabular form and, to facilitate interdisciplinary comparison, in
      relative numbers in a series of figures. Concerns raised by the trends revealed
      are outlined.

PMID- 1027868
TI  - Rationalizing the delivery of health care--part III.
AB  - Attempts to regionalize and rationalize the delivery of personal health services
      and eye care services in particular are beset with social, political and economic
      problems. A review of past attempts in this direction points out some of the
      difficulties. Recent legislative and professional developments provide clues as
      to the likelihood that the delivery of eye care will be rationalized in the
      future.

PMID- 1027869
TI  - Paraoptometric education and training in the United States Air Force.
AB  - The authors describe military optometry clinic personnel problems prior to 1971
      which led to the creation of the Air Force Optometry Specialist/Technician career
      field. The optometry Specialist, whose civilian counterpart is the optometric
      assistant/technician, receives a highly intensive 9 week resident course at the
      USAF School of Health Care Sciences. Additional mandatory training is received on
      the job and by a career development course specifically designed for the
      Optometry Specialist. An optional 2-year program is also offered through the
      Community College of the Air Force.

PMID- 1027870
TI  - Future of optometric education: a student view.
AB  - With the growth of optometry and the advent of a national health insurance plan,
      the practice of optometry will change. As it does, so too must optometric
      education. This paper outlines a student's views on how admissions, curricula,
      new schools, and board certification must change if optometry is to fill a
      primary health care role.

PMID- 1027871
TI  - Inspecting the integrity of hydrophilic lenses.
AB  - Inspection of the surface quality of hydrophilic lenses is important. Methods of
      inspection and illustrations of common defects are illustrated.

PMID- 1027872
TI  - The intermodality relationship of auditory and vision perception.
AB  - A review of the literature reemphasizes the importance of the intermodality
      relationship of auditory and vision perception in assisting children learning to
      read. Following a description of the neuro-pathways, hemispheric dominance
      theories and the developmental sequences, suggestions are provided for the
      application of the knowledge about auditory and vision perception in the
      prevention of the ever increasing number of children experiencing learning
      disabilities.

PMID- 1027873
TI  - Low vision case report.

PMID- 1027874
TI  - Training with a post-surgical exotrope.

PMID- 1027876
TI  - How to start a CME program in your hospital or medical society.

PMID- 1027875
TI  - Nominative evaluation in a residency training program.

PMID- 1027877
TI  - A defection from psychiatry to family practice?

PMID- 1027878
TI  - Are too many surgeons being produced in this country?

PMID- 1027879
TI  - Freedom in medical education.

PMID- 1027880
TI  - A position statement of the Association for Hospital Medical Education.

PMID- 1027881
TI  - The practicing family physician as a teacher and learner in a family practice
      residency.

PMID- 1027882
TI  - Continuing medical education fact sheet.

PMID- 1027883
TI  - Competence-based reregistration: a changing role for continuing medical
      education.

PMID- 1027884
TI  - The primary physician: bagels and lox for breakfast?

PMID- 1027891
TI  - Special diets and the School Meals Service in Norfolk.

PMID- 1027892
TI  - High resolution observation of biological specimens by an incoherent illumination
      method.

PMID- 1027893
TI  - Electron microscope studies of the vegetative cellular life cycle of
      Chlamydomonas reinhardi dangeard in synchronous culture. IV. Mitochondria in
      dividing cells.

PMID- 1027894
TI  - Electron microscopic studies on membrane system of Staphylococcus aureus by means
      of thin sectioning and freeze-replica techniques.

PMID- 1027895
TI  - Isolation and ultrastructural characterization of fine spirals (spirosomes) from
      Lactobacillus brevis.

PMID- 1027896
TI  - Fine structure of bacterial cell envelope studied by ultracryotomy.

PMID- 1027897
TI  - Freeze-etching observation on the nucleus of HeLa-S3 cell infected with
      adenovirus type 12.

PMID- 1027898
TI  - Rectangular arrays of intramembranous particles at the zonula adherens in the
      guinea pig organ of Corti.

PMID- 1027899
TI  - Freeze-drying technique for small biological materials using a modified freeze
      etching device.

PMID- 1027900
TI  - Bartley v. Kremens: a step backward?

PMID- 1027901
TI  - Quality assurance.

PMID- 1027902
TI  - All marriages are not in heaven made: the joining of quality assurance and
      utilization review.

PMID- 1027903
TI  - A program to evaluate intensive psychiatric hospital treatment.

PMID- 1027904
TI  - The adolescent treatment assessment project: lessons learned in process.

PMID- 1027905
TI  - Funding and planning a comprehensive mental health delivery system.

PMID- 1027906
TI  - [Anterior choroidal artery. II. Pathologic states (tumors)].

PMID- 1027907
TI  - [Anterior choroidal artery. I. Anatomic and radiographic study].

PMID- 1027908
TI  - Embolization with iodine 131-marked Spongel. Technique, indications and results.

PMID- 1027909
TI  - The EMI CT 1010 brain scanner. Technical aspects.

PMID- 1027910
TI  - Normal appearances of brain scans produced by computerized axial tomography.

PMID- 1027911
TI  - The EMI body scanner. An interim clinical evaluation.

PMID- 1027913
TI  - The value of the new EMI diagnostic display console.

PMID- 1027912
TI  - Computerized axial tomography.

PMID- 1027914
TI  - A topographic study of CT scan of brain tumours.

PMID- 1027915
TI  - The role of computerised axial tomography (EMI scanning) in the diagnosis and
      management of cranio-cerebral trauma.

PMID- 1027916
TI  - Aspects and evolution of cerebrovascular accidents.

PMID- 1027917
TI  - Computerised axial tomography in non-tumourous conditions.

PMID- 1027918
TI  - Acta Scanner and neuroradiology.

PMID- 1027919
TI  - The future of computerised axial tomography.

PMID- 1027920
TI  - Central nervous system antigen (NS-5) and its presence during murine ontogenesis.
AB  - An antiserum raised by immunization of C3H.SW/Sn mice with cerebellum from 4-day
      old C57BL/6J mice recognizes a cell surface component(s) [NS-5] present in
      different degrees on various parts of the mouse central nervous system. When
      analyzed by an antiserum- and complement-mediated cell cytotoxicity test and by
      the ability of various tissuesto absorb anti-NS-5 antiserum activity, the
      antigen(s) was detectable on cerebellum, retina, olfactory bulb, cortex, basal
      ganglia, and medulla but not on nonneural tissues with the exception of mature
      spermatozoa and 4-day-old kidney. The antigen(s) detected by the anti-NS-5
      antiserum was found in similar quantities on young and adult rat and mouse
      cerebellum; however, it was not detectable on any of 16 clonal cell lines derived
      from the rat central nervous system. During preimplantation stages of murine
      development, the antigen could be detected on all cells of (2-4)-cell and (8-16)
      cell stages and on the trophoblastic cells of blastocysts by indirect
      immunofluorescence, Embryos on day 9 of gestation, the earliest tested after
      implantation, expressed the antigen(s), but expression was restricted to the
      nervous system.

PMID- 1027921
TI  - The gating currents of sodium channels: pore-population-size effects.
AB  - Sodium-channel behavior has been modeled in order to determine the answer to the
      following question: How large must a population of "on-off" sodium pores be
      before the inherently random behavior of the individual channels becomes smoothed
      to yield the expected gating current-conductance relationships which would be
      predicted from an infinite pore array? Results of this analysis show that for the
      "opening" situation, an excellent fit was obtained whenever more than about 10
      pores were considered. Significant discrepancies were observed in the "closing"
      situation, however, for pore arrays of 50 or less. Marked hysteresis is apparent
      in the behavior of small port populations.

PMID- 1027922
TI  - Comparison of the structural and chemical composition of giant T-even phage
      heads.
AB  - A study has been made of the structure of the capsids of T4D giant phage produced
      from mutants in gene 23 and temperature-sensitive mutants in gene 24, and T4D and
      T2L giant phage formed by the addition of L-canavanine followed by an Larginine
      chase in the growth medium. All the giant phage capsids have been shown to be
      built according to the same geometrical architecture. This consists of a near
      hexagonal surface net, lattice constant 129.5 A, folded into a left-handed T = 13
      prolate icosahedron elongated along one of its fivefold symmetry axes. Their only
      apparent difference from wild-type T-even phage capsids is their abnormally
      elongated tubular part. A comparison of the capsomere morphologies and protein
      compositions of the giant phage capsids showed that all T4D giants are identical
      but differ from T2L: The T4D capsomere has a complex (6 + 6 + 1)-type morphology,
      whereas the T2L has a simple 6-type. T2L phage, however, lack two capsid
      proteins, "soc" and "hoc", present in T4D. The difference in capsomere morphology
      can therefore be related to the difference in the protein compositions of these
      two phage. Possible differences between the initiation and means of length
      regulation of giant phage heads and the aberrant polyheads are discussed.

PMID- 1027923
TI  - Effects of RNase and RNA on in vitro aster assembly.
AB  - RNase alters the in vitro assembly of spindle asters in homogenates of
      meiotically dividing surf clam (Spisula solidissima) oocytes. Some effects of
      RNase, such as reduced astral fiber length, appear nonenzymatic and probably
      result from RNase binding to tubulin. However, RNase-induced changes in the
      microtubule organizing center are also observed. Since other polycations can
      mimic RNase effects, the existence of an RNA component of the spindle organizing
      center remains uncertain. Effects of RNase and other polycations on astral fiber
      length can be prevented and reversed by the RNase inhibitor, polyguanylic acid.
      Polyguanylic acid can also augment astral fiber length in the absence of added
      RNase or other polycations. Augmentation by polyguanylic acid is favored by high
      ionic strength, and can be duplicated by polyuridylic acid and, with less
      efficiency, by polyadenylic acid. Polycytidylic acid and unfractionated yeast
      RNA, however, are unable to augment aster assembly. Polyguanylic acid can also
      augment the length of astral fibers on complete spindles isolated under
      polymerizing conditions. These results demonstrate that specific
      polyribonucleotides can alter spindle assembly in vitro. The presence of an
      inhibitor of microtubule assembly in Spisula oocytes, which can be inactivated by
      specific RNAs, is suggested.

PMID- 1027924
TI  - [Changes in thromboelastogram in women on hormonal contraception].
AB  - The authors have analysed changes in the thromboelastogram in 411 women on oral
      contraceptives and in 31 women on no hormonal contraception. Comparing the
      results they found no statistically significant differences because the control
      group was too small. In the group of women on hormonal contraception,
      statistically significant differences were recorded in those women whose
      thromboelastogram was analysed several times, the differences having been more
      pronounced in the women that had used hormonal contraceptives for a longer time.
      As the appearance of thrombo-embolic complications is a very complex process, the
      authors' opinion is that thromboelastogram cannot be considered as a routine
      method for predicting these complications.

PMID- 1027925
TI  - [Success in the induction of labor by peroral administration of Prostin E 2 in
      relation to Sandopart].
AB  - The results of the use of Prostin E2 in the induction of labour in 46 pregnant
      women were compared with the results obtained by Sandopart in 40 pregnant women.
      To avoid the effect of amnyotomy, both groups were examined without carrying out
      routine amnyotomy. The results have shown that a significantly better efficacy in
      the induction of labour was obtained with Prostin E2. This efficacy was very good
      regardless of the cervix assessed by the Bishop score, while the reaction of the
      uterus to Sandopart proved the poorer the lower the Bishop score. The mother's
      condition, established by clinical and laboratory examinations, did not change
      significantly in the course or after the administration of Prostin E2. Nor did
      the condition of infants, assessed by the Apgar score, differ from the condition
      of children from the group of labour induced by Sandopart. This shows that the
      induction by Prostin E2 is just as efficacious as the induction by Sandopart if
      the cervix is mature; if the cervix is not mature, the induction by Prostin E2 is
      even more efficacious.

PMID- 1027926
TI  - [Graphic monitoring of the latent phase of intensified labor].
AB  - In planned delivery it is often advantageous to be able to monitor the early
      course of stimulated labour. This paper describes the construction of a graph
      which defines the rate of progress of the latent phase of augmented labour in 307
      women, which represented 80% of a group of patients in a "low risk" category
      obstetrically.

PMID- 1027927
TI  - [Clinical significance of organic deposits on intrauterine contraceptive
      devices].

PMID- 1027928
TI  - [Leiomyoma of Bartholin's gland].
AB  - Out of 4676 gynecological surgeries, the authors came across one case of the
      leiomyoma of Bartholin's gland. The clinical picture differed from that in the
      cystic changes of this gland by its consistency; also the skin, the surrounding
      tissue, and regional lymphs of the gland were not changed. The authors maintain
      that all tumorous changes of Bartholin's gland should be treated surgically.

PMID- 1027929
TI  - [Malignant melanoma of the skin and pregnancy].
AB  - Two women, during pregnancy, suddenly developed changes in the pigmented skin
      nevus (melanoma) which they had had since their childhood. Both patients were
      surgically treated; the diagnosis was malignant melanoma. One of the patients, 12
      years after the operation, is alive and well, and so is her child. In the other
      patient, 6 months after operation, there was a relapse and regional metastases.
      She gave birth to a healthy child.

PMID- 1027930
TI  - [Torsion of the pregnant uterus].
AB  - Torsion of a 6-month gravid uterus in a secundigravida, showing the clinical
      shape of an acute abdomen and shock, is described. The uterus was twisted 180
      degrees from left to right, with a retroplacental haematoma and dead foetus. The
      symptoms occurred while the patient was sleeping. Sectio caesarea was performed
      and no other pathologic changes were found in the uterus, ovaries, or minor
      pelvis.

PMID- 1027931
TI  - [Abdominal pregnancy].
AB  - A 38-year-old woman, after a spontaneous abortion following extrauterine
      pregnancy, developed abdominal pregnancy which was diagnosed only 6 days before
      the term of delivery, although she had been regularly examined. In the first
      trimester of that pregnancy she wanted to interrupt pregnancy and an alleged
      artificial abortus was performed. By cesarean section a live, at term baby,
      3000/50, was born without any visible malformations. The placenta was left in
      situ because it partly adhered to the colon sigmoideum, mesosigma, and the wall
      of the small pelvis. Although it is better in abdominal pregnancy with cesaren
      section to remove the placenta immediately, the authors think that to leave the
      placenta in situ is safer if its position is such that to remove it would expose
      the patient to great risk.

PMID- 1027932
TI  - [Late gestoses complicated by amaurosis].
AB  - A case of amaurosis in the course of preeclampsia and one in eclampsia are
      presented. Since in both cases conservative therapy failed, the cesarean section
      was applied in both cases. The infants were of low birth weight but developed
      well. Amaurosis in both patients disappeared a few days after delivery. In such
      cases the authors advocate liberal indications for cesarean section.

PMID- 1027933
TI  - [2 cases of amaurosis during pre-eclampsia in pregnancy].
AB  - The author describes two cases of amaurosis in toxemia during pregnancy. Both
      pregnancies were completed by cesarean section. Vision returned to both patients
      on the third and the fourth day, respectively, following delivery. The follow-up
      findings 9 months after delivery were normal.

PMID- 1027934
TI  - [Bilateral extrauterine tubal pregnancy].
AB  - The authors analyse their surgical material over 17 years. Out of 4676
      gynecological operations, 416 related to extrauterine pregnancy, and only one of
      them was bilateral extrauterine pregnancy. The diagnosis in the latter case was
      made during the operation. The initial diagnosis was confirmed
      pathohistologically. The authors point out that during the operation it is
      necessary to control both ovarian tubes and that the material removed by surgery
      should always be examined pathohistologically.

PMID- 1027935
TI  - [Acute gangrenous cholecystitis with suppurative acute cholangitis in the 1st
      days of the puerperium].
AB  - A 25-year-old secundipara developed acute gangrenous cholecystitis coupled with
      suppurative cholangitis on the fourth pureperal day. The patient recovered after
      cholecystectomy and choledochotomy. It is pointed out that cholelithiasis is not
      rare in pregnancy but acute cholecystitis is very rare, especially in the
      puerperium. For this reason the diagnosis is difficult, yet the final issue
      depends on its early establishment and also on the early surgical intervention.

PMID- 1027936
TI  - [Use of aspiration curettage in ambulatory patients].
AB  - In 90 patients with metrorrhagia, aged 20-75, aspiration curettage with constant
      aspiration by a vacuum pump was applied. The most frequent clinical diagnosis was
      metrorrhagia dysfunctionalis (in 55 patients). The aspiration was performed
      without cervical dilatation, by using one ampoule of valoron i. v. by a cannula 3
      mm in diameter and a chamber with a built-in sieve for collecting aspiration
      material. Histological analysis revealed endometrial carcinoma in 4 cases, post
      abortion conditions in 29 cases, endometrial hyperplasia in 28 cases, while in
      the remaining patients the endometrium was normal. In 4 cases there was not
      enough material for analysis.

PMID- 1027937
TI  - [Vacuum extraction in interruption of pregnancy using a jagged cannula].
AB  - The author describes his experience with artificial abortus using vacuum
      aspiration performed with a jagged cannula of his own construction. In 2150
      interruptions of pregnancy, the complications were as follows: residua in 0.2%,
      bleeding in 4.7%, and febrile condition in 2.5% of cases. The loss of blood was
      30-200 ml.

PMID- 1027938
TI  - [Tocolysis in prevention of spontaneous abortion].
AB  - In the course of 1975 and 1976 the authors applied Partusisten (Th 1156 a) in 34
      pregnant women at the risk of spontaneous abortion in the 16th to the 28th week
      of pregnancy. The therapy started with intravenous infusions by means of an
      automatic electromechanic infusion pump; peroral application of the drug
      followed, both in hospital and for a certain period in outpatient treatment under
      the gynecologist's supervision. Out of 34 women, 27 remained pregnant for more
      than 37 week of gestation and gave birth to a live at-term baby; in 5 cases the
      success was relative, and only in 2 cases was there no success at all. According
      to the tocolysis index, at index 2 or less, the success was achieved in 87% of
      cases and at index exceeding 2, the success was achieved in 63% of cases. The
      side-effect observed was invariably tachicardia in the mother, while all other
      untoward effects (tremor, sweating, slight restlessness, etc) were tolerated very
      well. An extremely good effect of Partusisten is obvious, because in doses of 4
      micrograms/min, it promptly reduces the frequency and intensity of contractions.

PMID- 1027939
TI  - [Discussion on post-diploma continuing education in obstetrics and gynecology].

PMID- 1027940
TI  - [Current status and limitations of contraception].

PMID- 1027941
TI  - [Abortion, the failure of contraception].

PMID- 1027942
TI  - [Contraception in the immediate period following voluntary interruption of
      pregnancy (V.I.P.)].

PMID- 1027943
TI  - [Contraception and the gynecologic future].

PMID- 1027944
TI  - [Role of the wise woman in contraception].

PMID- 1027945
TI  - [The new information agencies on consultation and family planning].

PMID- 1027946
TI  - [Overcoming the obstacles of contraception].

PMID- 1027947
TI  - [Medicolegal aspects of contraception].

PMID- 1027948
TI  - Morphologic characteristics of the thymus in 70 cases of myasthenia.

PMID- 1027949
TI  - Effect of ethanol application during pregnancy on the electron microscopic image
      of a newborn brain.

PMID- 1027950
TI  - Effect of overnutrition and undernutrition on cellularity of rat epididymal fat
      pad.

PMID- 1027951
TI  - Influence of gamma radiation on the solubility of collagen-derived membranes.

PMID- 1027952
TI  - Gastric secretory response to ligation of pancreatic ducts, pancreatitis,
      pancreatic fistula and pancreatectomy in dogs.

PMID- 1027953
TI  - Influence of diphtheria toxin on free fatty acid mobilization and pressor
      responses to catecholamines.

PMID- 1027954
TI  - The effect of certain parasympathomimetic and parasympatholytic drugs on the
      gamma-aminobutyric acid content in the cerebral hemispheres of mice.

PMID- 1027955
TI  - Interactions of chloramphenicol with certain spasmogens on vas deferens of guinea
      pig.

PMID- 1027956
TI  - Acute experimental pancreatitis treated with glucagon Histological study (part
      I).

PMID- 1027957
TI  - New approach, facts and hypothesis on B virus hepatitis epidemiology and
      pathogenesis.

PMID- 1027958
TI  - Clinical and immunomorphological evaluation of pathological changes in the liver
      in collagenoses.

PMID- 1027959
TI  - The auto-brewery syndrome--the repeated attacks of alcoholic intoxication due to
      the overgrowth of Candida (albicans) in the gastrointestinal tract.

PMID- 1027960
TI  - Advances in colonoscopy.

PMID- 1027961
TI  - Common bile duct cysts.

PMID- 1027962
TI  - Normalizing effect of prednisone on excessive hydroxyprolinuria in active
      systemic lupus erythematosus.

PMID- 1027963
TI  - Clinical experiences with birth control in Poland.

PMID- 1027964
TI  - [Method of evaluating the acoustic properties of devices for auscultation].
AB  - It is suggested that the appraisal of acoustic properties of auscultation
      instruments should be done by an expert-physician by following the most
      outstanding auscultative characteristics. A procedure for medical appraisal of
      acoustic properties is proposed. The BF-1 sthetophonendoscope manufactured by the
      Nizhny-Tagil medical instruments plant is recommended to serve as a model one.

PMID- 1027965
TI  - [Increase in the information content of the image of the surface veins by using a
      television infrascope].
AB  - An enquiry into the possibility of obtaining an infrared image of superficial
      veins by using a TV infrascope demonstrated this method to be more sensitive by
      comparison with the IR-photography. The former procedure enables it to obtain a
      picture of the venous network superior by its informativeness to that obtained
      with the aid of IR-photography. This justifies recommending the procedure in
      question for the purpose of diagnosing conditions in which there appear changes
      in the superficial veins, in particular for diagnosing pregnancy, characterized
      by a progressive development of venous anastomoses in the region of the mammary
      glands.

PMID- 1027966
TI  - [Longitudinal radioisotope tomograph].
AB  - To-day the construction of an apparatus for longitudinal emissive tomography has
      become a problem of great urgency. The designed apparatus, as described herein,
      is based on the principle of the image superposition method and the results
      obtained are suggestive of possibilities for its efficient application in
      diagnosing diseases involving large organs, such as the brain, liver, etc.

PMID- 1027967
TI  - [Cryogenic device for local freezing and irrigation].

PMID- 1027968
TI  - [Diagnostic scintillation device with an increased accuracy of measurement].

PMID- 1027969
TI  - [Monitor control in severe forms of late pregnancy toxicosis].

PMID- 1027970
TI  - [Presterilization treatment of medical instruments for the purpose of lowering
      the sterilizing dose of gamma irradiation].
AB  - Preliminary treatment of medical instruments with a 1% sulphochlorantine solution
      for a period of 3 hours helps greatly reduce their initial contamination, permits
      it to lower the sterilizing irradiation dose down to 1.5 Mrad and to manufacture
      radiationally-sterilized medical instruments at any medical instruments plant.
      The instruments subjected to presterilization treatment in conjunction with radio
      resistent irradiation are non-toxic, apyrogenic and free from any functional
      changes.

PMID- 1027971
TI  - [Problems of medical equipment terminology].
AB  - It is recommended to standardize the biomedical engineering terminology by making
      use of greek latin terminological elements. The designations of biomedical
      engineering products should include terms featuring the fundamental functions of
      their technical arrangements, viz. the type of action, the method of examination,
      the surgical manipulation, the kind of treatment, by retaining the already
      established clinical terms. The second part in the designation of the technical
      arrangement should carry the name of the organ, cavity, region and system of the
      organism, of the tissue, etc, for whose handling the instrument or apparatus is
      intended.

PMID- 1027972
TI  - [Methods and modern apparatus for assisted circulation. The basic trends in their
      development].
AB  - A systematization of methods for assisted circulation, based on the formulation
      of a concrete procedure, the nature of the deranged or lost function substitution
      and conditions for effective realization of such a substitution, is offered. This
      made it possible to classify the equipment for assisted circulation and to
      analyze the current trends of its further development. The most characteristic
      automation levels of the equipment under consideration and of generations of some
      apparatus, differing in the degree of automation, control and monitoring the
      process of assisted circulation, are presented in the form of tables and
      pictures.

PMID- 1027973
TI  - [Method and schematic for contactless read-out from a mercury manometer].

PMID- 1027974
TI  - [Sprayer of liquid biological preparations].

PMID- 1027975
TI  - [Adaptor for the anesthetic apparatus in nasopharyngeal anesthesia].

PMID- 1027976
TI  - [Rational bases for technological equipment support for the anesthesiological
      service].

PMID- 1027977
TI  - [Frequency-contrast characteristics of an x-ray image intensifier].
AB  - To analyze intricate roentgeno-diagnostic complexes the need for application of
      frequency-contrast characteristics (FCC) is generally acknowledged at present.
      The paper presents a description of procedures used in an experimental definition
      and analysis of three-dimensional characteristics of roentgen image amplifiers
      constructed with a roentgen electron-optic converter serving as a base. As a
      result of an experiment the FCC of individual components of the amplifier have
      been determined, critical links in the device educed and the summary FCC of all
      its channels calculated. Possible ways of improving the parameters of the Soviet
      made units are indicated.

PMID- 1027978
TI  - [Modernization of the GT-2 gamma-topograph].

PMID- 1027979
TI  - [Device for introducing a drug substance into the body].

PMID- 1027980
TI  - [Electromechanical drive for a perfusion pump].

PMID- 1027981
TI  - [Use of polymethylmethacrylate for intensifying the treatment of steel parts in
      rotating containers].
AB  - Basic regularities governing the surface dispersion of lwo-carbon grades of steel
      in a polymer-abrasive medium during treatment of workpieces (the deburring,
      descaling and rounding of sharp edges) in revolving drum-containers were
      investigated. Relationships between the amount of the metal scraped off and the
      consumption of the abrasive filler, on the one hand, and the percentage of the
      polymer, on the other, as well as the influence exerted by the metal dispersion
      products and abrasive granules amassing in the containers of these relationships
      are shown. It is pointed out that the modification of the technological medium by
      adding polymethylmethacrylate to it helps increase the efficiency of the
      operation by a factor of two.

PMID- 1027982
TI  - [Improvement in the organizational structure of managing the medical industry].

PMID- 1027983
TI  - [Methods of cardiac synchronization in assisted circulation].
AB  - In assisted circulation cardiosynchronization should be regarded as a process of
      monitoring the arterial blood pressure within the limits of the cardiac cycle and
      changes of its form with the aim of improving the energy balance of the heart.
      The coordination of the pumping function and that of the cardio-vascular system
      comes to a problem of shaping the monitoring action that depends upon three
      variables, viz. the time lag tepsilon, actuation of the unit relative to the base
      cardiosignal, duration of the pumping phase  tpi and the signal level at the
      pump's inlet U(t). A number of researchers consider tepsilon and tpi to be a
      function of the cardiac contractions period and determine them in different ways,
      employing for this purpose extrapolation, stochastic characteristics, etc. Of
      late, in addition to the period of cardiac contractions extremal, mean integral
      values of the systolic and diastolic pressure, the level of pressure at the
      instant of the cardiac valves closure and others have also come in use. There are
      shortcomings in the proposed cardiosynchronization algorhythms: their empiric
      nature and also the fact that the monitoring action includes merely variables
      tepsilon and tpi and does not carry function U(t), which reflects the intensity
      of the pump's operation.

PMID- 1027984
TI  - [Quantitative measurement of human tendon reflexes].

PMID- 1027985
TI  - [Automatic digital computer processing of the galvanic skin reaction curve].

PMID- 1027986
TI  - [Cryocatheter-tourniquet].
AB  - To simplify the design of the cryo-instrument and to adapt it to the forms and
      dimensions of the organ undergoing surgery or of any other object a cryocatheter
      tourniquet is proposed, where a thin-walled, flexible tube passed in a loop like
      manner through the opening of another tube (after the type of a tourniquet), is
      used as a conduit of the cooling agent. The loop out on the object to be operated
      upon forms the working part of the cryosurgical appliance.

PMID- 1027987
TI  - [Device for the sterilization and storage of catheters and guides].

PMID- 1027988
TI  - [Laboratory apparatus for ultrafiltration].

PMID- 1027989
TI  - [Disinfection sprayers].

PMID- 1027991
TI  - ["Tonus-1" apparatus for treatment with diadynamic currents].

PMID- 1027990
TI  - [Device for electrophoresis on a polyacrylamide gel block].

PMID- 1027992
TI  - [Action of cryoprotectives glycerin, ethylene glycol, and dimethyl-sulphoxide on
      fertilisation potential of cock semen (author's transl)].

PMID- 1027993
TI  - State of the hypothalamic-pituitary neurosecretory system in rabbits with
      anaphylactic shock.
AB  - The hypothalamic-pituitary neurosecretory system of rabbits with anaphylactic
      shock was investigated by morphometric and histochemical methods. The volumes of
      the perikarya were increased and the dimensions of the nuclei and nuclei of the
      neurosecretory cells were reduced, and the content of neurosecretory substance
      throughout the neurosecretory system was increased. In rabbits dying from shock
      the volumes of the nuclei and nuclei were reduced by a lesser degree, the
      dimensions of the perikarya were changed, and the content of neurosecretory
      substance in the posterior lobe of the pituitary was reduced. In animals
      surviving shock the synthesis of neurohormones by the neurosecretory cells was
      thus sharply stimulated, but liberation of neurohormones from the posterior lobe
      was inhibited. In aminals dying from shock hormone formation in the
      neurosecretory cells was stimulated to a lesser degree, but the processes of
      liberation of neurohormones from the posterior lobe of the pituitary were
      probably intensified.

PMID- 1027994
TI  - Effect of catecholaminergic drugs on epileptogenic properties of the caudate
      nucleus.
AB  - Drugs stimulating catecholaminergic transmission (dopa, apomorphine, amphetamine,
      and their combination with disulfiram) weakened the epileptogenic properties of
      the caudate nucleus in freely moving rats. Under the influence of these drugs the
      cortical electroencephalographic response to single stimulation of the nucleus
      was shortened in animals receiving subconbulsant doses of leptazol and the
      intensity of the spike-wave rhythm bound with repeated caudate stimuli was
      reduced. Conversely, inhibitors of catecholaminergic transmission
      (chlorpromazine, haloperidol, alpha-methyltyrosine, and disulfiram) potentiated
      the epileptogenic effects of the caudate nucleus.

PMID- 1027995
TI  - Multiplication of the late slow component of the evoked potential to light during
      chlorpromazine administration.
AB  - In experiments on unanesthetized rabbits with electrodes permanently implanted
      into various brain formations the effect of chlorpromazine was studied on the
      phenomenon of multiplication of the late slow component of the evoked potential
      to flashes of light applied at a frequency of 1 Hz, some of which were given
      simultaneously with electric shocks to the hind limb. Chlorpromazine was found to
      reduce the multiplication of the slow component to flashes applied without
      electric shocks and to facilitate the reduplication of this component to flashes
      applied along with the nociceptive stimulation. In the discussion of the results
      a role of adrenergic structures is postulated in the formation of the defensive
      action acceptor, one of the most important and crucial mechanisms of the
      functional system.

PMID- 1027996
TI  - Functional organization of sleep states in normal and brain-damaged infants.
AB  - A polygraphic investigation was made of daytime sleep in healthy infants with
      analysis of the EEG, oculogram, muscle tone, fluctuations in skin resistance,
      respiration, ECG, rheoencephalogram, and rheogram of the leg. Infants with
      cerebral palsy of perinatal genesis were investigated by the same method. The
      results showed that in early infancy it is possible to distinguish the basic
      stages of slow sleep and the stage of fast sleep, although the
      electroencephalographic experssion of these stages in infants has special
      features of its own. The age dynamics of the polygraphic picture of sleep shows
      that the electroencephalographic, autonomic, and motor components of sleep,
      although clearly coordinated in the various stages, have at the same time
      considerable autonomy. This is confirmed by the results obtained by analysis of
      the cerebral pathology. The need for adequate assessment of this complex function
      in order to elucidate the physiological nature of sleep is emphasized.

PMID- 1027997
TI  - Submicroscopic localization of H3-noradrenaline in the hypothalamus.
AB  - The submicroscopic localization of H3-noradrenaline in the periventricular region
      of the anterior hypothalamus of the rat was investigated. It was shown that the
      largest concentration of the label is detected in the neuroglia of the
      subependymal layers, where the label is detected above the terminals of the axons
      with two types of vesicles and along the path of the axons above the
      microtubules. More rarely the label is encountered above the terminals with one
      type of synaptic vesicle and above cells of the neurosecretory type, similar in
      ultrastructure to cells of the arcuate nucleus. In the ependymal layer the label
      is localized above the cells and intercellular spaces. The results of the work
      are discussed in connection with the modern data on the fluorescence of the
      catecholamines of the hypothalamus.

PMID- 1027998
TI  - Mechanism of visual perception of movement.
AB  - We here present a logical mathematical model for the visual perception of
      movement in man; it is based on the treatment of signals in the retina in
      relation to time and distance and on the statistical theory of the separation of
      signal from noise in the visual system. It shows good agreement with experimental
      results and has made it possible to determine the comparative level of internal
      noise of the visual system, the mean rate of spread of excitation from the
      photoreceptors along the surface of the retina, and many other characteristics.

PMID- 1027999
TI  - Some features of the medium surrounding the mechano- and electroreceptors of the
      acousticolateral system of the ray Raja clavata.
AB  - The degree of binding of K ions has been investigated and the contents of free Ca
      ions and of glycosaminoglycans have been determined in the medium surrounding the
      mechano- and electroreceptors of the acousticolateral system of the ray Raja
      clavata; in addition, electrical phenomena in solutions of K hyaluronate in
      solutions of the media investigated have been studied. A comparison of the
      results of electrometric and chemical analysis has shown that the proportions of
      bound K ions as percentages of the total amounts of these ions are 36.4 in the
      endolymphatic jelly, 39.6 in the ampullar jelly, and 21.9 in the liquid of the
      lateral canals. The amount of Ca ions in the media investigated is 3.6-4.4
      meq/liter and is close to the concentration of these ions in sea water--3.4
      meq/liter. In the endolymphatic jelly the amount of glycosaminoglycans is 0.30+/
      0.022% of the wet weight, in the liquid of the lateral canals 0.21+/-0.026%, and
      in the jelly of the ampullae of Lorenzini 2.79+/-0.28%. Some characteristics of
      the "displacement potentials" of solutions of K hyaluronate and solutions of the
      jelly of the ampullae of Lorenzini have been determined, and some hypotheses have
      been put forward on the possible role of these potentials in the activity of the
      ampullar formations of the systems of organs of the lateral line.

PMID- 1028000
TI  - Activity of the neurons of the medial region of the septum of the rabbit brain in
      early ontogenesis.
AB  - In rabbits aged from seven days to two and a half months the activity of
      individual cells of the nucleus of the diagonal band of Broca (NDB) and of the
      medial nuclei of the septum (MNS) of the brain and the EEG of the dorsal
      hippocampus (DH) - the CA2-CA3 zones - have been recorded simultaneously. It has
      been found that the specific (burst) activity of the neurons of the septum
      appears first on the 8th-11th day of the background of the action of eserine. The
      distinct bimodal nature of the histograms of the interimpulse intervals
      characteristic of the burst sequence of distribution of the potentials appears
      only from an age of 14 days. The deficient nature of impulse-formation of the NDB
      and of the MNS is acquired at about the 20th day of life. A parallel evolution of
      the impulse activity of the cells of the medial region of the septum and the
      synchronized activity of the hippocampus in ontogenesis is traced. The formation
      of the theta activity correlates with an increase in frequency of the burst
      activity of the neurons of the septum connected with an increase in the mean
      frequency of impulse formation of the cells, the concentration of the impulses
      into a packet, and the growth of the regularity of the burst discharges with age.

PMID- 1028001
TI  - Effect of a unilateral cortical lesion on the monoamine content in the cat brain.
AB  - The serotonin and noradrenalin content in the cerebral cortex, hypothalamus, and
      mesencephalon was investigated spectrofluorometrically in 12 cats on the 5th-6th
      day after the production of a pathological focus in the region of the occipital
      cortex. Diffuse changes of brain activity were recorded on the EEG at this
      period: spike-like waves and slow waves of increased amplitude. A considerable
      increase in the serotonin concentration was observed in the cortex, with the
      effect predominant in the region immediately adjacent to the pathological focus.
      A tendency for the serotonin level to fall was observed in the hypothalamus and
      mesencephalon. The noradrenalin concentration in these brain structures showed no
      significant change. The role of serotoninergic structures of the brain in the
      mechanisms responsible for restoring the functional state of the brain after
      experimental injury is discussed.

PMID- 1028002
TI  - The spectrum of the calling signals, phonotaxis, and the auditory system in the
      cricket Gryllus bimaculatus.
AB  - In behavioral experiments with a Y labyrinth it was shown that phonotaxis in the
      female crickets in respect to the calling signals (CS) of the males depends on
      the spectrum of the signal. The necessary and sufficient condition for
      development of normal phonotaxis is the preservation of the first, low-frequenct
      (LF) component of the spectrum (5kHz). Signals with a time pattern identical to
      that of a CS but with a spectrum containing only the high-frequency (HF)
      component (12.5 kHz) do not evoke phonotaxis. HF signals in the frequency-range
      10-40 kHz evoke negative phonotaxis in females under conditions of "tethered
      flight". In the auditory system of the crickets, beginning with the tympanal
      organ, there is a clear separation of the elements effecting LF and HF signals.
      Two types of ascending interneurons transmitting acoustic information from the
      primary auditory center to the brain are described in detail. The first is
      connected primarily with LF receptors and transmits clearly all the time
      dependent characteristics of the CS most important for recognition. The second
      apparently participates in the production of negative phonotaxis. It is connected
      primarily with HF receptors, has considerable after-effect and also raises
      sensitivity to sounds of low intensity, emphasizes the initial moment in the
      effect of a stimulus, and "habituates" rapidly to repeated stimulations.

PMID- 1028003
TI  - Functional characteristics of stretch receptors of flight apparatus of cockroach
      Periplaneta americana.
AB  - The functional characteristics of the stretch receptors of the wing joints of
      Periplaneta americana were examined and the possible functional role of these
      receptors in the maintenance of a stable rhythm of flight is discussed. The
      stretch receptors of the wing joints are of the phasic-tonic type, with slow and
      incomplete adaptation by the receptors which discharge upon movement of the wing
      upward. The nature of the impulse response of a receptor depends both on the
      angle and the rate of movement of the wing membrane. The arrangement of a
      hypothetical pacemaker of the insect's wing beats is discussed in detail.

PMID- 1028004
TI  - Neural pathway of penetration of vitamin B1 into the central nervous system.

PMID- 1028005
TI  - Factors responsible for under-utilisation of primary health centre--a community
      survey in three states of India.

PMID- 1028006
TI  - Imparting of health education in the out-patient department of a metropolitan
      city hospital as viewed by the consumers.

PMID- 1028007
TI  - [Dyssymmetrical cytotomy and orientation of the spindles in early isolated
      blastomeres of gastropod molluscs].
AB  - While removing the vitelline membrane mechanically or by trypsinization, one or
      two blastomeres were isolated from two-, four- and eight-celled embryos Lymnaea
      stagnalis, Physa fontinalis and Ph. acuta. If a pair of blastomeres was isolated
      prior to the formation of the III and IV cleavage spindles, it became similar to
      a two-cell embryo; the spindles oriented in parallel to each other and the
      contact zone of blastomeres preserving the previous localization of the nuclei
      and the subsequent division was equal. If a pair of blastomeres was isolated in
      metaphase, the localization of spindles did not change and the relative size of
      sister blastomeres after the subsequent division resembled the normal size (in
      particular, the III division was unequal). In the course of division of isolated
      single blastomeres, as well as pairs of blastomeres with parallel spindles,
      mutual turns of sister cells along the plane of new furrow, always dexiotropic in
      Lymnaea and laetropic in Physa, were observed in all cycles. The ability of
      dissymmetrical invariant turns during cytotomy, shown earlier when studying the
      whole embryos, is, thus, inherent to each blastomere irrespective of the
      neighbour ones but is supressed during the normal development after the III
      division mechanically due to the dense cellular packing projected by the
      orientation of spindles.

PMID- 1028008
TI  - [Expression of the paternal genes for lactate dehydrogenase, glutamate
      dehydrogenase and acetylcholinesterase in the development of hybrid fish between
      species from the families of Cobitidae and Cyprinidae].
AB  - The time of expression of the paternal genes of glutamate dehydrogenase (GDH),
      lactate dehydrogenase (LDH) and acetylcholine esterase (AChE) was investigated in
      the development of fish hybrids. The species which differed by the
      thermostability of homologous enzymes were selected as parental pairs. The
      appearance of differences in the thermostability of homologous enzymes between
      the hybrids and the maternal species suggested the beginning of paternal enzyme
      synthesis in the hybrid embryos. Differences in the AChE thermostability appeared
      simultaneously with the enzyme activity at the stage of first muscle contractions
      (35 hrs of development), differences in the mitochondrial GDH thermostability
      appeared at the stage of hatching (50-60 hrs) and those in the LDH
      thermostability 12-17 days after hatching. The total activity of AChE and GDH
      sharply increased during the period of the paternal enzyme appearance whereas the
      activity of LDH suffered practically no changes. Differences in the AChE
      thermostability between the hybrids and the maternal species are the same for
      both the total AChE (in supernatant, 15,000 gX10 min.) and the solubilised AChE
      (in supernatant, 130,000 gX60 min.). AChE of the parental species and the hybrids
      have the same electrophoretic mobility. The differences in the thermostability of
      enzymes are preserved following the electrophoresis in polyacrilamide gel.

PMID- 1028009
TI  - [Pathways of terminal erythrocyte differentiation in birds. An analysis of the
      intermediate forms].
AB  - The erythropoiesis during anemia is characterized by the reduction of the bone
      marrow period of cell development. Two immature forms, absent in the normal
      state, were shown to be present under anemia: basophilic erythroblasts and
      reticulocytes with basophilic cytoplasm. These forms are interposed between the
      bone marrow basophilic erythroblasts and erythrocytes. Some basophilic
      erythroblasts turn out in the peripheral blood and transform into basophilic
      reticulocytes there. The level of transcription in anemic animals during the
      transformation of basophilic erythroblasts into basophilic reticulocytes does not
      decrease and is higher than that in polychromatophilic erythroblasts. The total
      chromatin condensation does not reflect the decrease of the transcription level.

PMID- 1028010
TI  - [DNA synthesis in the brain and liver of rats in various stages of postnatal
      development].
AB  - The intensity of incorporation of 3H- and 14C-thymidine in the brain and liver
      DNA in rats of different ages was investigated. It was proved that both the
      replicative and oxyurea-resistant DNA synthesis might proceed in the rat brain
      cells. The intensity of these processes changes sharply during postnatal
      development.

PMID- 1028011
TI  - [Morphological, cytochemical and radioautographic analysis of the development of
      a population of mitral cells of the rat olfactory bulb in prenatal ontogeny].
AB  - The dynamics of DNA synthesis, its ratio to the proliferative activity and
      changes in the amount of genetic material in mitral cells of the white rat
      olfactory bulb during prenatal ontogenesis, as well as in newborn rats are
      considered. The lengthening of G2-phase, decrease of mitotic activity and
      increase of DNA content in the nuclei of forming mitral cells were shown to occur
      in the period from 18 till 20 days of embryogenesis.

PMID- 1028012
TI  - [Localization of aldolase activity in the embryos of loach].
AB  - The activity of aldolase was determined in different parts of the loach
      (Misgurnus fossilis L.) embryo at the stages from the formation of axial organs
      till the beginning of embryonic movements (from 19 till 38 hrs of development at
      21.5 degrees). In all parts of the embryo, the activity of aldolase at first
      decreased (21-23 hrs) and then increased. The region of somites is characterized
      by the highest absolute and specific activity at all developmental stages. The
      increase in the number of somites is accompanied by the fall and subsequent rise
      of aldolase activity. In the somites of different degree of differentiation, the
      enzyme activity changes in a similar way. Hence, there is no correlation between
      the morphological and biochemical differentiation of somites. Differences in the
      specific aldolase activity between the anterior and posterior halves of the
      embryo and the regions of head, somites and tail were found at the stages of 19
      23 hrs of development. The maternal aldolase only is present at these stages, as
      was shown earlier. It means that the early stages of biochemical differentiation
      may be realized not by means of differential activation of genes controlling the
      enzyme, but by means of regylation of translation on the templates stored in
      oogenesis.

PMID- 1028013
TI  - [Effect of metopirone and glucocorticoids on the glycogen content in the adrenals
      of rat fetuses].
AB  - Metopiron, hydrocortisone and dexamethazone are able to influence different links
      of the hypothalamo-hypohysial-adrenal system and induce the inhibition of
      glucocorticoid function. Changes in glycogen content in the adrenal gland and
      liver of rat foetuses under the effect of the drugs in question were studied. It
      was shown that metopiron exerted no marked influence on the level of glycogen in
      the adrenal gland and decreased 2.5 times that in the liver. On the contrary,
      hydrocortisone and dexamethazone increased the glycogen content 2 times in the
      adrenal gland and did not change that in the liver. The results obtained agree
      with the hypothesis on the relation between the glycogen level in the adrenal
      gland and the level of its hormonal activity and are considered as an additional
      proof of the functioning of hypothalamo-hypophysial-adrenal system during the
      last days of the rat prenatal development.

PMID- 1028014
TI  - [Generalization of growth equations].

PMID- 1028015
TI  - [2 unusual cases of early embryogenesis].
AB  - Two unusual cases of early embryogenesis are described: a giant cleaving egg and
      the presence of two generations of embryos in the genital tract of a female--at
      the stage of implantation and at the stage of two blastomeres. The ability of
      development of the second generation was tested in vitro experiments.

PMID- 1028016
TI  - The need for an animal model of chronic pain.

PMID- 1028017
TI  - Local oedema and general excitation of cutaneous sensory receptors produced by
      electrical stimulation of the saphenous nerve in the rat.

PMID- 1028018
TI  - Inhibition of visceral pain by electrical stimulation of the periaqueductal gray
      matter.
AB  - Numerous recent studies demonstrated that electrical stimulation of the
      periaqueductal gray matter (PGM) can result in powerful analgesia to pain of
      somatic origin. In the present study, we have developed a visceral pain test
      employing intraperitoneal injection of hypertonic saline which yields a writhing
      response in the adult rat more reliably than other pain-producing substances.
      With this test we show that writhing as well as the response to radiant heat
      (tail flick test) are completely inhibited in all animals with PGM electrode
      placements.

PMID- 1028019
TI  - Responses of intradental nerves to chemical and osmotic stimulation of dentine in
      the cat.
AB  - Recordings have been made of the neural responses evoked by stimulation of
      dentine with solutions of NaCl, NH4Cl and dextrose. Stimulation of the outer
      dentine produced no response. From the inner dentine, a smaller number of
      impulses were recorded with solutions of NaCl than with corresponding
      concentrations of NH4Cl, but a much larger number than with solutions of
      dextrose. The discharge evoked by a solution increased in mean frequency and
      decreased in latency as the thickness of dentine was reduced. The responses
      suggest that the receptors were in the innermost dentine or the pulp and that
      they were excited by changes in extracellular fluid composition rather than by
      osmotic effects. The properties of the receptors appear to be different from
      those involved in pain from dentine in man.

PMID- 1028020
TI  - Nociceptor-driven dorsal horn neurones in the lumbar spinal cord of the cat.

PMID- 1028021
TI  - Illness behaviour syndromes associated with intractable pain.
AB  - One hundred patients, referred for the management of intractable pain, completed
      a 52-item Illness Behaviour Questionnaire (IBQ). Responses were scored on 7
      scales: general hypochondriasis, disease conviction, psychological versus somatic
      perception of illness, affective inhibition, affective disturbance, denial, and
      irritability. IBQ scale profiles were subjected to numerical analysis and 6
      taxonomic clusters were identified. Patients in groups 1-3 were characterized by
      a relatively non-neurotic, reality-oriented attitude to illness, as indicated by
      low scores on the first three scales. Patients in groups 4-6 manifested greater
      evidence of 'abnormal illness behaviour', and presented syndromes resembling
      'hysteria', 'conversion reaction', and 'hypothchondriasis' respectively.

PMID- 1028022
TI  - Words of chronic pain.
AB  - An analysis of the language of pain complaints, employing categories of
      descriptors, was used to determine if chronic pain of either psychiatric of
      organic origin might be depicted in terms specific for the disease. The
      complaints of 128 patients with chronic pain were studied for characteristic
      patterns. Patients with pain of organic etiology used sensory-thermal (e.g., hot,
      burning) words more frequently than those with pain of psychiatric origin. Female
      patients with pain attributed to anxiety used sensor-temporal words (e.g.,
      throbbing) more frequently than those with other psychiatric diagnoses. There was
      also a statistically significant preponderance of pain on the left when the
      groups of patients with physical and psychological illness were combined.

PMID- 1028023
TI  - Differential effect of morphine on trigeminal nucleus versus reticular aversive
      stimulation: independence of negative effects from stimulation parameters.
AB  - Electrodes were implanted in mesencephalic, pontine, and bulbar reticular
      formation, and in spinal trigeminal nucleus and tract of rats. Central and
      peripheral aversive response thresholds  were studied under normal conditions and
      with morphine. Peripherally elicited aversive reactions were assessed with tail
      flick, hot-plate, and footshock responses. Centrally elicited aversive reaction
      thresholds were in all cases based on unconditioned behavioral distress signs
      (non-stereotyped, escape-like movements, vocalization, freezing, excretion, etc.)
      and confirmed in some cases with avoidance learning. Morphine (10 mg/kg) elevated
      the unconditioned aversive reaction threshold for brain stimulation in the
      trigeminal complex and for peripheral aversive stimulation, but failed to affect
      the thresholds for reticular brain stimulation. The failure to affect reticular
      thresholds was independent of stimulation frequency. Thresholds for 5 and 200 Hz
      sinusoidal stimulation were both unaffected as were previously reported
      thresholds with 333 Hz pulsatile stimulation. Trigeminal nucleus and tract
      stimulation were affected in similar degrees. The data were discussed as
      supporting descending inhibitory models of opiate analgesia.

PMID- 1028024
TI  - Modulation of shock-elicited pain by acupuncture and suggestion.
AB  - An experimental investigation of acupuncture's analgesic potency, separated from
      suggestion effects, is described, in which judgments of shock-elicited pain of
      the forearm were recorded along two separate scales: intensity and aversiveness.
      Data from experimental subjects, who received electrical acupunctural stimulation
      through surface electrodes located over acupuncture points and were given
      explicit counter-suggestions of sensitization, were compared to those obtained
      from control subjects, who received such stimulation over incorrect loci and were
      given explicit suggestions of analgesia. No alterations in the perception of pain
      intensity, either by acupunctural stimulation or suggestion, could be detected at
      any time during the experiment, but stimulation of the correct points produced a
      significant analgesic reduction in aversiveness which was specific to the arm so
      stimulated, overcame the counter-suggestion of sensitization, and persisted after
      stimulation was discontinued. No significant reductions were recorded from
      control subjects. These findings are interpreted in light of other experimental
      acupuncture research, and of the demonstrated mode of action of analgesics of
      proven efficacy.

PMID- 1028025
TI  - Results of 19 years experience with sacral rhizotomy for perineal and perianal
      cancer pain.

PMID- 1028026
TI  - Radioimmunoassay for measurement of fibrinogen.

PMID- 1028027
TI  - Histidine active transport system in rabbit erythrocytes.

PMID- 1028028
TI  - Relation between mast cells and serum zinc levels.

PMID- 1028029
TI  - Glucose-6-phosphate dehydrogenase activity in human platelets and its secretion.

PMID- 1028030
TI  - Two point discrimination and ageing.

PMID- 1028031
TI  - Secondary myeloid metaplasma in a case of IgD myeloma.

PMID- 1028032
TI  - Systemic lupus erythematosus with renovascular hypertension accompanied by
      thrombosis of renal artery and renal vein (case report).

PMID- 1028033
TI  - [Certain myelomorphological shifts in the process of bone regeneration after
      thyrocalcitonin administration].

PMID- 1028034
TI  - [Modification of the method of transauricular hypophysectomyA1].
AB  - The authors describe a modification of the method of transauricular
      hypophysectomy. Anatomical reference-points suggested permit to direct the
      extractor directly to the gland without any use of additional instruments
      (goniometers, apparatus for fixation of the animal head, etc.). A detailed
      description of the course of the operation and of the instruments used is
      presented.

PMID- 1028035
TI  - [Method of study of epidemiology of diabetic angiopathies].
AB  - The authors present a method of a perspective study of the epidemiology of
      diabetic angiopathies with the use of standardized methods of examination of the
      cardiovascular system, including the assessment of microangiopathies and also
      glycemia and lipid metabolism indices in accordance with the WHO recommendations.
      This method can be used by endocrinologists, therapeutists and physicians of
      other specialties in studying the factors influencing the development of vascular
      affections in patients with diabetes mellitus.

PMID- 1028036
TI  - [Clinical characteristics of selectivity of proteinuria in patients with diabetes
      mellitus].
AB  - A study was made of 43 patients suffering from diabetes mellitus using the method
      of proteinuria selectivity on polyacrylamide gel. Two types of proteinuria were
      distinguished: the first type repeated the electrophoregram of the plasma
      proteins completely or partially, the second type--the selective one--was
      characterized by excretion of individual plasma proteins. Diagnostic and
      prognostic value of the method of proteinuria selectivity is discussed.

PMID- 1028037
TI  - [Basic trends in the development of endocrinology in the light of the resolutions
      of the 25th Congress of the CPSU].

PMID- 1028038
TI  - [Androgenic function of the adrenal glands in children with acceleration of the
      growth and development].
AB  - A study was made of the urinary excretion of neutral 17-ketosteroids (sum total
      and individual fractions) in 65 accelerated children, aged from 7 to 16 years.
      The information on the excretion of androgenic compounds pointed to an earlier
      and increased functional activity of the adrenal cortex and gonads in children
      with acceleration of the growth and development.

PMID- 1028039
TI  - [Pathoanatomical studies in hypermuscular lipodystrophy].

PMID- 1028040
TI  - [Therapy in the medical information system of the polyclinical endocrinological
      department].

PMID- 1028041
TI  - [Development of thyrotoxicosis in patients with nodular goiter and cretinism].

PMID- 1028042
TI  - [Case of hypopituitary syndrome in a man].

PMID- 1028043
TI  - [Development of alloxan diabetes and its effect on the sexual system of male rats
      under conditions of alpha adrenergic receptor blockaders].
AB  - A study was made of the influence of the block of the alpha-adrenoreceptors in
      male rats on the development of alloxan diabetes and on such its complication as
      depression of the sexual system function. Phetholamine sharply decreased the
      death of the animals the first 3--4 days after the alloxan administration: only
      5.3% of the animals died. As to rats with intact alpha-adrenoreceptors--42% of
      the died. Block of the alpha-adrenoreceptors decreased the percentage of rats
      with marked diabetes. In 37.2% of rats given alloxan and phentholamine diabetes
      was very mild or failed to develop entirely. Phentholamine significantly lowered
      the depressive effect of alloxan diabetes on the sexual system considerably.

PMID- 1028044
TI  - [Mechanism of the effect of hydrocortisone on the lymphoid cell lipids].
AB  - It was experimentally established that a single administration of hydrocortisone
      to rabbits in a dose of 50 mg/kg caused a reduction in the lymphoid cells of the
      mesenteric lymph nodes of triglycerides and free fatty acids; this was
      accompanied by a fall of total lipids in the cells.

PMID- 1028045
TI  - [Effect of hydrocortisone on sodium and potassium distribution in the sections of
      the cerebral cortex of rats after their electric stimulation].
AB  - Sections of the rat brain cortex were incubated in various physiological media
      using container-electrodes, similar to the McIlwain's type. The shifts of sodium
      and potassium distribution between the extra- and intracellular spaces of the
      slices after different stimulation parameters and the subsequent restoration were
      measured. The administration of hydrocortisone (for 7 days, 5 mg/100 g daily)
      usually increased the response of the slices to the stimulation in incubation in
      the glutamate devoid medium. When 0.2--0.5 mM of glutamate was added to the media
      the effect of hydrocortisone disappeared. Possible physiological significance of
      the mentioned results is discussed.

PMID- 1028046
TI  - [Certain properties of estrogen receptors in the cell nuclei of different organs
      of rats].
AB  - Some properties of the macromolecules, specifically binding estradiol (E2) of
      salt chromatin extracts of the nuclei of the kidneys, liver, prostate, testes and
      the uterus of rats were studied. Examination of competition of various unlabeled
      hormonal preparations with 3H-E2 for the binding sites demonstrated the E2
      binding macromolecules of the nuclei of all the organs under study to have a high
      hormonal stereo-specificity. The E2-binding macromolecules of the nuclear
      extracts of the kidney, liver and the uterus were sensitive to the action of
      pronase. In sedimentation with ammonium sulfate of proteins from the 0.3 M NaCl
      extracts of the nuclei of the kidneys and liver, but not of the uterus, the
      supernatent fraction of the salt-treated extracts showed an additional (in
      comparison with control) specifically E2-binding macromolecule activity,
      sensitive to the action of pronase. An analogous effect of the appearance of
      additional binding activity could be obtained in heating of the nuclear extracts
      of the kidney and the liver at 60--100 degress C for 5 minutes.

PMID- 1028047
TI  - [Classification of the main kidney diseases in diabetes mellitus].
AB  - In the suggested classification of affections of the kidneys in diabetes mellitus
      the main attention is paid to the vascular genesis of the appearing disturbances.
      The terms used formerly ("diabetic glomerulosclerosis", "diabetic nephropathy")
      failed to reflect the primary affections of the vessels. The following new terms
      are suggested: "diabetic microangionephropathy" (affection of the small vessels),
      "macroangiography" (affection of the large vessels), "diabetic angionephropathy"
      (complex affection of the renal vessels). "Pyelonephritis" (acute and chronic)
      was also introduced into the classification due to its exceedingly frequent
      occurrence in diabetes. The term "diabetic nephropathy" is suggested for complex
      affection including diabetic angionephropathy and pyelonephritis. Diabetic
      microangionephropathy should be divided into four clinico-laboratory stages;
      their characteristics are presented. Particular attention was paid to the
      accessibility of their diagnosis in medical institutions.

PMID- 1028048
TI  - [Quantitative evaluation of the dose-response relationship after intramuscular
      administration of testosterone and its esters].
AB  - Experiments were conducted on rats. A study was made of the reaction of target
      organs to the intramuscular injection of androgenic preparations--testosterone
      and its esters (acetate, propionate, phenylpropionate, isocapronate, enantate and
      caprinate) comparison with anabolic methylandrostendiol. An equation is presented
      for mathematical description of the dependence of the androgenic effect on the
      dose of the praparations injected, used in a wide range of doses. The equation
      coefficients proved to have a definite physiological sense.

PMID- 1028049
TI  - [Analysis of various components of the mechanism of stimulation of
      transepithelial sodium transport by catecholamines].
AB  - A study was made of the influence of adrenaline of certain components of the
      transepithelial sodium transport system in the frog skin an on energy sources
      providing its activating effect. Adrenaline proved to increase the sodium
      transport through the frog skin decreasing its electrical resistance.
      Strophanthin K prevented the reaction of frog skin adrenaline completely.
      Monoiodacetate also produced an inhibitory action on the adrenaline effect which
      was eliminated on addition of pyruvate into the solution. Potassium cyanide and
      2,4-dinitrophenol considerably weakened the adrenaline stimulation of
      transepithelial sodium transport. A conclusion was drawn that an increase of
      sodiun transport by the frog skin in the action of catecholamines was associated
      with increase of its ionic permeability and the activation of the ionic pump. It
      is supposed that the principal source of energy provision for the stimulating
      effect of catecholamines were processes of aerobic energy metabolism.

PMID- 1028050
TI  - A preparation of field bean (Vicia faba L.) cotyledons as a substitute for dried
      skim-milk in calf feeding [proceedings].

PMID- 1028051
TI  - Ascorbic acid saturation levels in young and old guinea-pigs [proceedings].

PMID- 1028052
TI  - The influence of dietary ascorbic acid on the concentration of mercury in guinea
      pig tissues [proceedings].

PMID- 1028053
TI  - Orange-peel flavonoids and the growth and ascorbic acid status of hypovitaminotic
      C guinea-pigs [proceedings].

PMID- 1028054
TI  - The role of ascorbic acid in allergic reactions [proceedings].

PMID- 1028055
TI  - The absorption and distribution of 59Fe in chicks with acute Salmonella
      gallinarum infection [proceedings].

PMID- 1028056
TI  - Insulin secretion in young and adult offspring of rats given diets of varying
      protein and sucrose content during pregnancy and lactation [proceedings].

PMID- 1028057
TI  - Dietary protein and energy as determinants of foetal growth in the rat
      [proceedings].

PMID- 1028058
TI  - Are long-chain polyunsaturated fatty acids necessary in the human diet?
      [proceedings].

PMID- 1028059
TI  - The possible nature of the hypocholesterolaemic action of a mould (Fusarium)
      [proceedings].

PMID- 1028060
TI  - Measurement of liver protein turnover in genetically obese mice using DL-[2
      3H]glutamic acid [proceedings].

PMID- 1028061
TI  - Lipolytic and lipogenic activities of adipose tissue during spontaneous fat
      depletion and repletion [proceedings].

PMID- 1028062
TI  - The role of biotin in the stress-induced death of chickens exhibiting fatty liver
      and kidney syndrome [proceedings].

PMID- 1028063
TI  - The effect of dietary sucrose on the metabolism of pentobarbitone [proceedings].

PMID- 1028064
TI  - Estimation of heat loss from human subjects at four experimental temperatures,
      using a direct calorimeter and heat-flow meters [proceedings].

PMID- 1028065
TI  - Fat mobilization during exercise following dietary and exercise-induced changes
      in muscle glycogen [proceedings].

PMID- 1028066
TI  - Time of glucose syrup ingestion to alleviate initial exercise hypoglycaemia
      [proceedings].

PMID- 1028067
TI  - Role of glucocorticoid in the enzyme overshoot response to starvation-refeeding
      [proceedings].

PMID- 1028068
TI  - The effect of ethanol on resting metabolic rate [proceedings].

PMID- 1028069
TI  - The fermentation of polyalcohols by rumen microbes in vitro [proceedings].

PMID- 1028070
TI  - Pyridoxine deficiency in severe liver disease [proceedings].

PMID- 1028071
TI  - Altered morphology and pathways of DNA synthesis in small intestinal epithelium
      in dietary folate deficiency [proceedings].

PMID- 1028072
TI  - Influence of dieldrin on the production and characteristics of the egg and
      utilization of calcium and phosphorus in the quail (Coturnix coturnix japonica)
      [proceedings].

PMID- 1028073
TI  - Anthropometry in a Sudanese village; changes after 7 years [proceedings].

PMID- 1028074
TI  - Variations in serum chemistry in normal subjects without changes in diet
      [proceedings].

PMID- 1028075
TI  - Determination of methionine in the seeds of legumes [proceedings].

PMID- 1028076
TI  - The effect of dietary carbohydrate on the utilization of protein by the growing
      pig [proceedings].

PMID- 1028077
TI  - The oxidation in vivo of uniformly and carboxyl-14C-labelled methionine by young
      pigs [proceedings].

PMID- 1028078
TI  - Sterols in cerebrospinal fluid during nitrosourea chemotherapy of human brain
      tumors.

PMID- 1028079
TI  - The influence of banana supplemented diet on gastric ulcers in mice.

PMID- 1028080
TI  - Effect of a new synthetic prostaglandin on acid gastric secretion of different
      laboratory animals.

PMID- 1028081
TI  - Pharmacokinetic studies of S-adenosyl-L-methionine (SAMe) in several animal
      species.

PMID- 1028082
TI  - Isolation of a hyaluronate pool from the chondroitin sulfate peptide pool of calf
      rib cartilage. Effect of puromycin and SeO4(2-) on pool labeling with 3H
      glucosamine.

PMID- 1028083
TI  - [Family-oreinted therapy in the social situation - an example (author's transl)].

PMID- 1028084
TI  - [Controlled drinking in alcoholism therapy (author's transl)].

PMID- 1028085
TI  - [Survey of psychiatrists with a private practice and clinical psychiatrists
      regarding the present situation of the care of psychiatric patients in Berlin
      (author's transl)].

PMID- 1028086
TI  - [Influence of nonpharmocologic factors on the administration of neuroleptic drugs
      for acute treatment of hospitalized psychiatric patients (author's transl)].

PMID- 1028087
TI  - [Recreational retreats with chronic mentally ill patients (author's transl)].

PMID- 1028088
TI  - [The epileptic problem-patient from the point of view of the district hospital
      (author's transl)].

PMID- 1028089
TI  - [Serum calcium evaluation and incidence of primary hyperparathyroidism in
      hospitalized patients (author's transl)].
AB  - Automated laboratory procedures have made possible to "screen" a large population
      for specific biochemical abnormalities. Primitive hyperparathyroidism is for
      several respects an excellent disease model for testing "mass screening". Il is
      often asymptomatic, not uncommon, and is manifested by abnormalities in the
      levels of serum calcium and inorganic phosphorus, that can be detected cheaply
      with automated equipment. A computer program has been developed to screen
      patients with hypercalcaemia. During a period of 18 months 22720 hospitalized
      patients were investigated by the evaluation of serum calcium, and 80
      hypercalcaemic patients were found. The diagnosis of primary hyperparathyroidism
      was established in 24 patients (in 19 histologically confirmed) so that the
      incidence of primary hyperparathyroidism (1,05%) compares favorably with that
      reported from some foreign Authors.

PMID- 1028090
TI  - [Behaviour of urinary excretion of lysozyme in renal diseases and in urinary
      tract infections (author's transl)].
AB  - Urinary excretion of lysozyme was investigated in a group of 66 patients with
      various renal diseases, nephrolitiasis and urinary tract infections. The results
      obtained demonstrate that the amount of the enzyme excreted is related to the
      entity of tubular damage whereas is not with glomerular damage. No correlation
      was found between lysozyme excretion neither to the degree of proteinuria neither
      to the amount of leukocytes and bacteria in the urine. In patients with urinary
      infections urinary lysozyme increases only when there is a tubular injury of some
      entity. In 90 pediatric patients with urinary infection and pyelonephritis
      lysozyme in the urine was found only in two cases. Therefore urinary lysozyme
      determination cannot be considered for the detection of early tubular injury and
      is not a helpful diagnostic tool in urinary tract infections.

PMID- 1028091
TI  - [Relation between age, sex and various metabolic parameters: blood uric acid
      (4776 specimens), blood sugar (7211 specimens), blood cholesterol (5600
      specimens) and blood triglycerides (4438 specimens)].
AB  - The connection between age, sex and some laboratory parameters (blood uric acid,
      glucose, cholesterol and triglycerides) has been studied on a very wide whole
      (22025 exams). An important datum which has appeared is that the increase of age
      is connected with an increase of the values of the parameters studied, and that
      the sex conditions differences which proved statistically significant.

PMID- 1028092
TI  - [A proposed hepatic pie chart].
AB  - The AA. have chosen 12 tests to organize an "hepatic flash" after a selection out
      of 180 cases scheduled as the table no. I through a set of tests showing step by
      step any modifications in compliance with the sensibility, reliability,
      statistical clinical and physio-pathological meaning of each test. The 12 tests
      are set out by circular abscissae of a circus according to the pathogenetic
      mechanisms leading to their modifications. By the radial ordinates, instead, it
      is shown the decreasing and increasing values which every test may assume. An
      hypothetic line (hepatogram) links then the values set out during the process of
      the disease in such a manner that the particular shapes assumed by the line
      itself show quickly and visually the spreading rate of the disease process.

PMID- 1028093
TI  - [Utilisation of Olivetti P 652 calculator system for RIA evaluation (author's
      transl)].
AB  - The AA. take into consideration the utilisation of the Olivetti calculator system
      including the following hardware: P 652 basic unit microcomputer; paper tape
      reader LN 20; Editor 4 ST typewriter, for RIA evaluation. For this purpose they
      have compiled a series of generalized programmes that utilise for the calculation
      of the standard curve, the logit transform fitted by using a linear regression or
      a cubic regression and the sigmoidal linear logarithmic curve calculated by cubic
      regression. Other two programmes are described also for automatic data reduction
      in the detection of hepatitis associated antibody (anti-Australia antigen) and of
      normalized serum thyroxine.

PMID- 1028094
TI  - [Determination of glycemia. Comparison between the enzymatic method and those of
      Folin-Wu and of ortho-toluidine (author's transl)].
AB  - On 1032 serum's samples, the determination of glycemia has been at the same time
      performed with methods enzymatic, of Folin-Wu and of ortho-toluidine. The
      obtained results, arranged, with the relative frequency, in progressive order
      from 40 to 470 mg%, have been compared among themselves, taking as base's value
      that of the method of Folin-Wu. After a description of the chemical reactions,
      which occur during the enzymatic determination of the glycemia, and of the causes
      of error, which can to interfere on the same determination, it has been discussed
      the validity and the specificity of this method. Effectively this method seems,
      besides being constantly reproduceable and of simple execution, to consent the
      best estimation actually possible of the glycemia. It is recommendable a general
      acceptance of the enzymatic method, executable also with Auto-Analyzer, so that
      the glycemic values of the same and of the different laboratories could be among
      themselves comparable.

PMID- 1028095
TI  - [Comparison between two automatic methods, chemical and enzymatical, of urea
      determination in blood (author's transl)].
AB  - Two different kinds of automatic dosage of urea in blood, the chemical with
      diacetyl monoxime and the enzymatic urea test Sclavo, are compared in order to
      verify the possibility of an utilization in screening on population. For such a
      purpose also the influence of different anti-coagulants is analyzed.

PMID- 1028096
TI  - [Bacteriuria detection by dip-slide test (author's transl)].
AB  - A new dip-inoculum method markated as Microstix for detecting bacteriuria was
      studied to evaluate its usefulness as a screening procedure. This test was found
      to be reliable when compared with the standard pour plate method. However,
      antimicrobial agents often present in the urine samples rendered this procedure
      unsuitable for indiscriminate application in large hospital laboratories. This
      technique might conceivably be employed in mass screening programs where urine
      specimens are less likely contamined by antimicrobial drugs.

PMID- 1028097
TI  - [Analysis of urinary calculi. Study methods].
AB  - A comparative study of the composition of a hundred urinary gravel stones is
      carried out, made by chemical analysis and spectroscopy infra-red. This research
      has shown that the spectroscopic method is better than chemical analysis: the
      latter method is excessively sensitive, above all when considering magnesium,
      phosphates and uric acid. The marked chemical disclosure of these substances
      takes us to false conclusions regarding the composition of the gravel stone with
      percentages varying between 20 and 40% of the cases. On the other hand chemical
      analysis has not revealed the presence of oxalates in 24% of the gravel stones
      examined. The spectroscopic method has shown itself to be simpler and faster to
      execute (a part from being more sensitive and precise), and capable of furnishing
      precise information on the composition of gravel stones, even very small ones of
      a weight of 500 microgram.

PMID- 1028098
TI  - [A commercial available kit for semiquanititative determination of plasmatic and
      urinary aminoacids by thin layer chromatography (author's transl)].
AB  - A commercially available kit (Amino-acid TLC kit-Sibar, Perugia, Italy) for
      screening of plasma aminoacids inborn errors has been used as routine method for
      plasma newborn examinations in a mid-size clinical Laboratory. Good results were
      obtained by this inexpensive and simple kit.

PMID- 1028099
TI  - [Premalignant lesions and initial stages of vaginal carcinoma].

PMID- 1028100
TI  - [Considerations on the surgical treatment of the double uterus].

PMID- 1028101
TI  - [Consideration on congenital cervical ectropion].

PMID- 1028102
TI  - [Splenectomy in children. Review of 75 cases].

PMID- 1028103
TI  - [IgA deficiency: Clinical analysis].

PMID- 1028104
TI  - [Immunological factors in infantile diarrhea].

PMID- 1028105
TI  - [Pneumonia caused by gram negative pathogens].

PMID- 1028106
TI  - [BCG generalization and immunodeficiency].

PMID- 1028107
TI  - [Familia study of 3 cases of Noonan's syndrome].

PMID- 1028108
TI  - [Hypertrophic pyloric stenosis].

PMID- 1028109
TI  - [Infra-clinoidal carotid aneurysm of traumatic origin. Review and case report
      (author's transl)].

PMID- 1028110
TI  - [Esthesioneuroblastoma of olfatory nerve. Study of a case (author's transl)].

PMID- 1028111
TI  - [Orbicular muscle paralysis its diagnostic and tretment (author's transl)].

PMID- 1028112
TI  - [Clivo-cervical chordoma (suboccipital and transoral approach)].

PMID- 1028113
TI  - Cytology of human early implantation.

PMID- 1028114
TI  - How does the copper intrauterine device work?

PMID- 1028115
TI  - Puberty.

PMID- 1028116
TI  - The action of phosphocreatine and fructose 1,6-diphosphate on blood in vitro.
AB  - Blood in vitro has been used to evaluate the effects of phosphocreatine and
      fructose 1,6-diphosphate on the adenylate cycle. These compounds, following
      different metabolic pathways, increased the ATP concentration, phosphocreatine
      through a direct action on the adenylic phosphate cycle and fructose 1,6
      diphosphate mainly by it glycolytic effect.

PMID- 1028117
TI  - Biochemical changes in extracorporeal circulation in patients.
AB  - The effect of priming extracorporeal perfusion pumps with 50% and 80% diluted
      homologous blood on the serum electrolytes, acid-base status and plasma
      osmolality has been investigated in 103 patients undergoing open-heart surgery
      for congenital and acquired heart disease. The value in prognosis of plasma
      osmolality is discussed.

PMID- 1028118
TI  - Burns caused by monitoring equipment during anaesthesia.
AB  - Hazards of monitoring during anaesthesia are burns, cardiac arrest or ventricular
      fibrillation, electric shock and false alarms caused by interference with the
      traces. The causative and contributory factors and the measures for the
      prevention of burns are discussed.

PMID- 1028119
TI  - Diagnosis of brain death.

PMID- 1028120
TI  - Coronary heart disease.

PMID- 1028121
TI  - Artificial circulation for resuscitation after prolonged clinical death caused by
      hypoxia.
AB  - The dynamics of dying and the subsequent recovery of the main vital functions
      such as cardiac performance, respiration and unconditioned reflexes were
      investigated in 24 dogs resuscitated by Bryukhonenko's method of artificial
      circulation after 13-15 min clinical death caused by asphyxia. Application of
      artificial circulation during asystole required a gradual increase for 2-3 min in
      the volume of perfusion to optimum levels, since too rapid an increase of blood
      flow resulted in secondary ventricular fibrillation. In conditions of
      resuscitation with high volumes of extracorporeal perfusion (exceeding 100 ml kg
      1 min-1), fast return of vital functions, their subsequent normalization, and
      relatively smooth recovery, can be achieved. Decreasing the rate of blood flow to
      60-80 ml kg-1 min-1 delays the recovery of vital functions of the resuscitated
      organism. Severe post-resuscitation disease develops with a fatal outcome.
      Resuscitation with flows of 40 ml kg-1 min-1 or less is ineffective. We concluded
      that successful resuscitation after clinical death caused by asphyxia was
      possible only when the blood flow was 1.2-1.5 times higher than the normal
      cardiac output.

PMID- 1028122
TI  - Plasma volume expansion after infusion of 5%, 20% and 25% albumin solutions in
      patients.
AB  - Fifty grams of albumin were infused into patients in the immediate post-operative
      period as either 5, 20 or 25% solutions. With all three solutions the increase in
      plasma volume was 500 ml or 11 ml/g of retained albumin, which is less than the
      normal water-binding capacity of albumin found in studies in vitro and in some
      clinical studies. This might be explained by a blocking of the water-binding
      capacity of the albumin or by the action of other unknown mechanisms, when
      albumin is given in an amount exceeding the losses. The expansion of the plasma
      volume did not depend on the concentration of the solutions given but only on the
      amount of albumin given and the deficit in plasma volume. Since albumin is a good
      plasma expander and a drug with a few secondary effects it is recommended in the
      treatment of shock. We prefer the 5% solution, which contains an electrolyte
      solution and is more easily infused, because of its low viscosity.

PMID- 1028123
TI  - New drug for the treatment of trachoma (clinical trial report).

PMID- 1028124
TI  - To the question of the geographic distribution of pterygium.

PMID- 1028125
TI  - Disappearance of trachoma in Bulgaria.

PMID- 1028126
TI  - Tropical endemic limboconjunctivitis.

PMID- 1028127
TI  - Ultrastructural study of trachoma and inclusion conjunctivitis.

PMID- 1028128
TI  - [Electroencephalography in learning problems of students].

PMID- 1028129
TI  - [The teaching of psychiatry and its relation to medical practice].

PMID- 1028130
TI  - [Considerations about the study of the pre-language].

PMID- 1028131
TI  - [Interruption of pregnancy during the third trimester: techniques, indications
      and results (author's transl)].

PMID- 1028132
TI  - [Epidemiologic contribution to the etiology of chronic bronchitis. IV. Results of
      a transversal epidemiologic survey in miners and controls of various occupations
      in a coal-mining district].

PMID- 1028133
TI  - [Morphological data obtained with light and electron microscopes concerning the
      ovary in the Stein-Leventhal syndrome treated with clomiphene citrate].

PMID- 1028134
TI  - [Cytotoxic antibodies in pregnancy].

PMID- 1028135
TI  - [Effects of ovulation-inducing drugs on peripheral receptors].

PMID- 1028136
TI  - [Hemangiopericytoma of the vulva].

PMID- 1028137
TI  - [Maternal mortality in the Obstetrical-Gynecological Division of the United
      Hospitals of Leghorn].

PMID- 1028138
TI  - [Idiopathic orthostatic hypotension: Shy-Drager's syndrome (author's transl)].
AB  - The authors report a clinical case of idiopathic orthostatic hypotension with
      associated signs of focal cerebrovascular lesion. They discuss aetiopathologic
      hypotheses which have been proposed to interpret pathological situations of this
      type. It seems reasonable to attribute an autonomous disease classification to
      idiopathic orthostatic hypotension as a systemic degenerative disease concerning
      peripheral and central structures with vegetative functions. The Shy-Drager
      syndrome (idiopathic orthostatic hypotension associated with diverse signs of
      involvement of the central nervous system) must not, however, be considered as an
      independent form of disease. The associated signs are none other than the
      expression of commonly found cerebral ischemic lesions deriving from abrupt
      arterial hypotension, or from cerebral dysautoregulation; or the expression of
      the association of a systemic degenerative disease with another, a not infrequent
      occurrence well known in the pathology of the nervous system.

PMID- 1028139
TI  - [Recording methods of intracranial pressure. (author's transl)].
AB  - The physiopathology of intracranial pressure and its measuring techniques are
      briefly discussed. Such measurements may be achieved: 1) At lumbar level
      (measurement of cerebrospinal fluid): the main limitations of this method are due
      to impossibility of long term recording and the danger of "cerebral erniation* in
      patients with increased ICP. 2) At cranial level with: a) ventricular catheter
      connected to a pressure transducer: its limitations are due to difficulties in
      entering small and/or displaced ventricules in case of cerebral edema or
      expanding lesion, danger of infections, and catheter obstruction amongst others.
      b) pressure transducer in the extradural space connected with external recorder
      by electric wires: its limitations are due to frequent lack of parallelism with
      the dural surface and the variability of correlations between extra and
      intradural pressure; c) subdural pressure transducer; these appear the most
      reliable both from the literature and from the Authors personal experience. The
      Authors stress the importance of ICP monitoring in head injuries and after
      intracranial surgery (mostly for an early detection of complications due to
      cerebral edema or hemorrhages).

PMID- 1028140
TI  - Tick-borne encephalitis (TBE) in Italy: report of the first clinical case.
AB  - Previous studies on the clinical features of meningoencephalitis in Italy did not
      help to indicate the nature of the causative agents. On the other hand during the
      past decade nine arboviruses were isolated in Italy, some of which are yet to
      prove pathogenic for man. A systematic study was carried out in cooperation
      between the Department of Neurology of the University of Florence and the
      Istituto Superiore di Sanita (Rome), in order to understand a possible role of
      arboviruses as etiologic agents of meningoencephalitis in Italy; in this
      preliminary communication the first clinical case of Tick-Borne Encephalitis
      (TBE) virus infection is described.

PMID- 1028141
TI  - [Subarachnoid haemorrhage from an ependymoma of the filum terminale. (author's
      transl)].
AB  - The case of a patient suffering from acute lumbosciatic pain, flaccid paraplegia,
      bladder retention and subarachnoid hemorrage, is reported. The patient underwent
      operation for a large ependymoma of the filum terminale. The author underlines
      the rare association of a spinal cord tumour and subarachnoid hemorrage and the
      opportunity of a routine mielo-radiculographic examination in case of lumbo
      sciatic pain requiring surgical intervention: the patient, in fact, had been
      operated for "lumbar disc prolapse", in an orthopaedic department, four years
      before.

PMID- 1028142
TI  - Childlessness, health, and marital satisfaction.

PMID- 1028143
TI  - Characteristics of voluntarily and involuntarily childless wives.

PMID- 1028144
TI  - Sex of children and ultimate family size by time and class.

PMID- 1028145
TI  - Testing the economic theory of fertility with cross-sectional and change data.

PMID- 1028146
TI  - Measuring mortality trends and differentials.

PMID- 1028147
TI  - Use of recall data in survey research on human sexual behavior.

PMID- 1028148
TI  - Emotional disturbance in unplanned versus planned children.

PMID- 1028149
TI  - Prevalence of divorce among parents of children with cystic fibrosis and other
      chronic diseases.

PMID- 1028150
TI  - Dysgenic trend in intelligence: comment on Cattell's "differential fertility and
      normal selection for IQ: some required conditions in their investigation".

PMID- 1028151
TI  - Sex differentials in morbidity and mortality in the United States.

PMID- 1028152
TI  - A study of the membership of the National Organization for Non-Parents.

PMID- 1028153
TI  - Assortative marriage for specific cognitive abilities in Korea.

PMID- 1028154
TI  - Ethnic differentials in neonatal and postneonatal mortality: a birth cohort
      analysis by a binary variable multiple regression method.

PMID- 1028155
TI  - A conceptual model for the identification, organization, and measure of influence
      of fertility policies and programs.

PMID- 1028156
TI  - Husband-wife age differentials in Shiraz, Iran.

PMID- 1028157
TI  - Asynchronous DNA replication and asymmetrical chromosome loss in Chinese hamster
      mouse somatic cell hybrids.
AB  - A number of parameters were measured in a series of 12 hybrid cell clones from
      Chinese hamster and mouse cells to test the hypothesis that asymmetrical
      chromosome loss may result from asynchrony in the replication of the two parental
      sets of chromosomes. All clones tended to lose telocentric (mouse) chromosomes
      with culture time, irrespective of the starting ratio of parental chromosomes,
      and in all clones, biarmed (hamster) chromosomes appeared to complete DNA
      replication slightly earlier than telocentrics. However, no quantitative
      correlation could be established between the degree of asynchrony in chromosome
      DNA replication and the extent of chromosome loss. It appeared that telocentric
      chromosomes were lost more readily from those clones which started with a high
      hamster-to-mouse chromosome ratio.

PMID- 1028158
TI  - Reactivation of chick erythrocyte nuclei in heterokaryons with temperature
      sensitive Chinese hamster cells.
AB  - Chinese hamster cell line K12 is temperature-sensitive for the initiation of DNA
      synthesis. K12 cells synchronized by serum deprivation were collected in early
      G1(G0). Heterokaryons were formed by fusing chick erythrocytes with serum-starved
      K12 cells through the use of UV-irradiated Sendai virus. At the permissive
      temperature (36.5 degrees C), erythrocyte nuclei in heterokaryons enlarged, the
      chromatin dispersed, and erythrocyte nuclei synthesized DNA at about the same
      time as the K12 nuclei. At the restrictive temperature (41 degrees C),
      erythrocyte nuclei enlarged, but neither erythrocyte nor K12 nuclei initiated DNA
      synthesis. When erythrocyte nuclei were fused with Wg-1A cells, the wild-type
      parent for ts K12 cells, both kinds of nuclei synthesized DNA at 36.5 degrees C
      and 41 degrees C. Activation of erythrocyte nuclei was inefficient in
      heterokaryons incubated in low-serum medium. The results indicate that serum
      factors and a cellular function defined by the K12 mutation are required for
      activation of chick erythrocyte nuclear DNA synthesis.

PMID- 1028159
TI  - Biochemical genetics of Chinese hamster cell mutants with deviant purine
      metabolism III. Isolation and characterization of a mutant unable to convert IMP
      to AMP.
AB  - The isolation and characterization of a new mutant of Chinese ovary cells (CHO
      K1) is described. This mutant, Ade-H, has the following properties: (1) it forms
      a new genetic complementation group; (2) it specifically requires adenine for
      growth and will not grow on aminoimidazole carboxamide (AIC) or hypoxanthine; (3)
      it accumulates IMP; (4) it cannot synthesize adenine nucleotides; (5) its
      phenotype can be mimicked by treatment of CHO-K1 (the wild type parental strain)
      with hadacidin, an inhibitor of adenylosuccinate synthetase (E.C.6.3.4.4). Thus,
      the site of the defect in this mutant is presumed to involve the step in
      adenylate biosynthesis catalyzed by this enzyme. The usefulness of Ade-H for the
      study of regulation of purine biosynthesis in mammalian cells is discussed.

PMID- 1028160
TI  - Cytogenetically marked clones in human fibroblasts cultured from normal subjects.
AB  - Clones of cytogenetically abnormal cells have been recognized in fibroblasts
      cultured from normal human adult skin. No such clones have been observed in human
      embryo skin fibroblasts cultured in the same way. Although the culture conditions
      may have played some part in the emergence of these clones, it is possible that
      the abnormal cells from which the clones were derived were present in vivo.

PMID- 1028161
TI  - Nucleotide analysis of DNA and RNA in cells with thymidine totally replaced by
      bromodeoxyuridine.
AB  - The nucleotide composition of nuclear DNA has been determined in a cell line
      (HAB) that has grown for 275 generations with complete substitution of
      bromodeoxyuridine (BrdU) for thymidine in nuclear DNA. Within 50 generations
      there is a approximately 3% decrease in the G content and an equivalent increase
      in the BrdU content of DNA, relative to the unsubstituted parent cell line.
      However, these alterations do not continue to accumulate when the cells are grown
      for up to 275 generations with fully substituted DNA, suggesting that they are
      not brought about by BrdU-induced base transitions due to mispairing. RNA
      transcription has been examined both in vivo and in vitro to determine whether or
      not BrdU substitution in DNA results in large-scale transcriptional errors. The
      nucleotide composition of 18S and 28S rRNA from cells 0, 60%, and 100%
      substituted with BrdU does not significantly differ. Further, when DNA from these
      cells is transcribed in vitro with E. coli RNA polymerase, there is no evidence
      for altered incorporation of nucleotides into RNA made from the substituted
      templates.

PMID- 1028162
TI  - Isolation and characterization of temperature-sensitive mutants of Chinese
      hamster ovary cells after treatment with UV and x-irradiation.
AB  - The isolation of ten conditionally lethal temperature-sensitive mutants of the
      Chinese hamster ovary cell (CHO-Kl, pro-) by the BUdR-visible light selection
      procedure described. Treatment with radiation at doses known to cause single gene
      mutation in mammalian cells increases the mutation frequency by a factor of at
      least 14. These mutants will grow with normal plating efficiency at 34.5 degrees
      but will not grow at 39.5 degrees. Complementation analysis by two independent
      methods indicates that all mutants are recessive and allows the assignment of the
      mutants to six genetically independent complementation groups. Reversion analysis
      indicates that the TS-mutants are stable, spontaneous revertants arising at a
      frequency of less than 10(-6). Preliminary chromosome analysis revealed no
      systematic chromasomal abnormality in the mutants. Mitotic accumulation is used
      to study the generation time of the parental cells and representative mutants at
      34.5 degrees and 39.5 degrees. The uses of these mutants for genetic analysis of
      mammalian cells in culture is discussed.

PMID- 1028163
TI  - Expression of human hypoxanthine phosphoribosyl transferase in Chinese hamster
      cells treated with isolated human chromosomes.
AB  - Chinese hamster cells deficient for the enzyme hypoxanthine phosphoribosyl
      transferase (HPRT) were incubated with isolated human metaphase chromosomes and
      21 colonies were isolated in HAT medium. Three different types of cell lines were
      established from these clones. First, 4 cell lines had 10-30% of normal Chinese
      hamster HPRT activity with the same electrophoretic mobility as human HPRT. This
      HPRT activity remains detectable during at least 8 weeks of growth of the cells
      in nonselective medium. Second, 3 cell lines also had human-like HPRT with the
      same activity as the first type. This HPRT persists only if the cells are grown
      in HAT medium and disappears during 8 weeks of growth in nonselective medium.
      Third, other clones survived in HAT medium as well as in medium with 8
      azaguanine. These cells had no detectable HPRT activity. Using differential
      chromosome staining techniques no recognizable human chromosome fragments were
      found in any of the cell lines.

PMID- 1028164
TI  - Improved techniques for the induction of mammalian cell hybridization by
      polyethylene glycol.
AB  - Modifications in the techniques for the induction of mammalian somatic cell
      hybridization by polyethylene glycol (PEG) have led to procedures that are rapid,
      simple, and effective. The basic improvements, for both monolayer and suspension
      fusions, are a short exposure to PEG and a rapid dilution of PEG following
      treatment. There is a marked effect of PEG concentration on cell hybridization,
      and there seem to be inherent differences between cells in terms of the extent of
      cell fusion induced by PEG.

PMID- 1028165
TI  - Assignment of the gene for cytoplasmic glutamic-oxaloacetic transaminase to the
      region q-24-qter of human chromosome 10.
AB  - Somatic cell hybrids between thymidine kinase-deficient mouse cells and human
      fibroblasts carrying a translocation of the distal third of the long arm of
      chromosome 10 to chromosome 17 were studied for the expression of cytoplasmic
      glutamic-oxaloacetic transaminase. A positive correlation between the expression
      of human cytoplasmic glutamic-oxaloacetic transaminase and the presence of the
      distal third of the long arm of chromosome 10 was established.

PMID- 1028166
TI  - Differential staining of interspecific chromosomes in somatic cell hybrids by
      alkaline Giemsa stain.
AB  - Staining of chromosome preparations of Chinese hamster-human hybrid cells and
      mouse-chimpanzee hybrids with alkaline Giemsa has yielded color differentiation
      of the interspecific chromosomes. Bicolor chromosomes, indicating apparent
      translocations also are observed for each of these hybrids. The specific color
      differences observed provide a rapid means of recognizing and aiding in the
      identification of the interspecific chromosomes and apparent translocations in
      these somatic cell hybrids.

PMID- 1028167
TI  - Biochemical selection systems for mammalian cells: the essential amino acids.
AB  - The essential amino acid requirement of cultured mammalian cells can be satisfied
      by 19 amino acid derivatives. This finding (a) confirms the results of animal
      nutritional studies and (b) identifies 19 essential amino acid derivatives and
      should permit the isolation of a new class of auxotrophic mutants. Five naturally
      occurring auxotrophic markers have been detected in this survey; namely,
      inability to utilize cystathionine and citrulline in Chinese hamster ovary (CHO)
      cells, inability to metabolize citrulline by HTC+hepatoma cells, and confirmation
      of Eagle's observation that KB cells can utilize homocystine in place of
      methionine or cystine and D-cystine in place of L-cystine.

PMID- 1028168
TI  - Biochemical genetics of Chinese hamster cell mutants with deviant purine
      metabolism. IV. Isolation of a mutant which accumulates adenylosuccinic acid and
      succinylaminoimidazole carboxamide ribotide.
AB  - The production, isolation, and characterization of a new complementation group
      (Ade-I) of adenine-requiring mutant of Chinese hamster cells (CHO-K1) is
      described. This mutant accumulates two intermediates of purine biosynthesis, both
      of which contain an aspartate moiety. One of these is shown to be adenylosuccinic
      acid (AMPS) by chromatographic analysis, while evidence is presented that
      strongly suggests the other intermediate is succinylaminoimidazole carboxamide
      ribotide (SAICAR). Thus, Ade-I is most likely lacking the activity of the enzyme
      adenylosuccinase (EC 4.3.2.2). The use of this and similar mutants for the
      analysis of regulation of purine biosynthesis in mammalian cells is discussed.

PMID- 1028169
TI  - Expression of transformation in cell hybrids. I. Isolation and application of
      density-inhibited Balb/3T3 cells deficient in hypoxanthine
      phosphoribosyltransferase and resistant to ouabain.
AB  - A cell line, THO2, was isolated from Balb/3T3 clone A31 after sequential
      nitrosoguanidine treatments and selection for resistance to 6-thioguanine and
      ouabain. THO2 retains the properties of density-dependent inhibition of growth
      and serum dependence of DNA synthesis characteristic of 3T3. The codominant
      expression of ouabain resistance and inability of THO2 to utilize exogenous
      hypoxanthine in the presence of aminopterin allows isolation of somatic cell
      hybrids involving THO2 and any ouabain-sensitive, hypoxanthine
      phosphoribosyltransferase-positive cell line. Hybrid clones derived from THO2 and
      SV40-transformed cells show dominant expression of the transformed phenotype with
      respect to multilayered arrangement of cells and ability to synthesize DNA in 1%
      calf-serum medium.

PMID- 1028170
TI  - Human diploid fibroblast mutants with altered RNA polymerase II.
AB  - Clones resistant to the cytotoxic action of alpha-amanitin have been isolated
      from a strain of fetal human lung diploid fibroblasts. Resistant clones were
      recovered at a frequencey of 5 X 10(-8) after single-step selections following
      mutagenesis with the mutagen ethyl methane sulfonate. Following propagation in
      drug-free medium, the clones retained the selected phenotype and in both growth
      and plating experiments showed a 10-50-fold higher resistance than wild-type
      cells to the cytotoxicity of 0.25 microgram/ml alpha-amanitin. The alpha-amanitin
      sensitivity of RNA polymerase II purified from the mutant cells suggests the
      presence of two forms of the enzyme, one similar to that found in wild-type cells
      and a second form with increased resistance to alpha-amanitin inhibition. These
      results are consistent with previous evidence that alpha-amanitin resistance
      behaves as a codominant marker in mammalian cells.

PMID- 1028171
TI  - Isolation of mutants lacking branched-chain amino acid transaminase.
AB  - Variants of the Chinese hamster ovary cell have been isolated which can no longer
      grow when valine, leucine, or isoleucine is replaced in the culture medium by its
      respective alpha-keto acid: alpha-ketoisovaleric acid, alpha-ketoisocaproic acid,
      or alpha-keto-beta-methylvaleric acid. These variants lack branched-chain amino
      acid transaminase activity. Evidence is presented indicating these variants to be
      single gene mutants. Genetic evidence is also presented confirming previous
      biochemical evidence that a single enzyme carries out transaminase functions on
      valine, leucine, and isoleucine. The branched-chain transaminase-deficient (trans
      ) mutants can be reverted to wild-type behavior by treatment with mutagenic
      agents. These mutants promise to be useful in exploring regulatory mechanisms in
      biochemical, genetic, and cancer research.

PMID- 1028172
TI  - Isolation and partial characterization of three methotrexate-resistant phenotypes
      from Chinese hamster ovary cells.
AB  - Three mechanisms for resistance to methotrexate (Mtx) have been identified in
      Chinese hamster ovary (CHO) cells selected from resistance to this drug. First
      step selections produce cells with either an apparent structural alteration in
      the enzyme dihydrofolate reductase (class I), or a decreased permeability to the
      drug (class II). Mutagenesis with ethyl methanesulfonate increases the proportion
      of Mtx-resistant cells 5-10-fold. Second-step selections to higher resistance
      using class I resistant cells as parents results in cells with an increased
      activity of the reductase enzyme (class III) with no apparent further qualitative
      alterations in the enzyme. All three classes of resistant cells retain their Mtx
      resistant phenotype when cultured under nonselectivve conditions.

PMID- 1028173
TI  - Dimethyl sulfoxide enhances polyethylene glycol-mediated somatic cell fusion.
AB  - The efficiency of fusion of human diploid cells by polyethylene glycol was
      greatly enhanced by addition of dimethyl sulfoxide. The extent of fusion was
      directly proportional to the concentrations of both of these compounds. At all
      except the highest concentrations, cell loss was moderate to minimal and
      perturbation of cell cycle function as measured by [3H] thymidine labeling
      indices and mitotic indices was minimal in the surviving cells. This technique is
      potentially useful for heterokaryon studies as well as for the isolation of
      hybrids of mammalian somatic cells.

PMID- 1028174
TI  - Polyethylene glycol-induced mammalian cell hybridization: effect of polyethylene
      glycol molecular weight and concentration.
AB  - The effects of polyethylene glycol (PEG) molecular weight and concentration on
      mammalian cell hybridization were studied. The peak hybridization-inducing
      activity with all grades of PEG from 400-6000 was found to occur in the
      concentration range of 50-55%. However, changes in concentration were seen to
      have different quantitative effects with different grades of PEG. For monolayer
      fusions, PEG 1000 at 50% seems to be the optimal combination of PEG molecular
      weight and concentration, in terms of both efficiency of hybridization and
      relative insensitivity to dilution effects.

PMID- 1028175
TI  - Medical staff wins in bylaws dispute.

PMID- 1028176
TI  - CT decision: to buy or not to buy?

PMID- 1028177
TI  - New AHA indexes to put prices in perspective.

PMID- 1028178
TI  - Hospital workers get six-month pay freeze following strike and binding
      arbitration.

PMID- 1028179
TI  - Bylaws by law: a look at the St. John's decision.

PMID- 1028180
TI  - What is the attorney's duty in a medical malpractice case?

PMID- 1028181
TI  - A physician recruitment plan that works.

PMID- 1028182
TI  - The strike that nobody won.

PMID- 1028183
TI  - Multihospital systems: the older they get, the better they run.

PMID- 1028184
TI  - Continuing education a must, trustees say.

PMID- 1028185
TI  - Contamination formed around a very narrow electron beam.
AB  - Specimen contamination in the electron microscope is studied in an attempt to
      clarify the processes involved in contamination deposition. A very narrow
      electron beam has been used to make small peaks of contamination on the surface
      of a thin carbon film. These peaks have been imaged and the rates of growth of
      the height, diameter and volume determined. It is concluded that a portion of the
      contamination can be related to the interaction of the electron beam with the
      adsorbed surface layer. Surface migration of adsorbed material is indicated as
      the supply mechanism. Significant deposition of material in regions not exposed
      to the beam is reported for the first time. A method for determining the
      thickness of thin amorphous carbon film in the range of a hundred to a few
      thousand Angstroms is described.

PMID- 1028186
TI  - Stereoscopy techniques for the electron microscope.

PMID- 1028187
TI  - Electronmicroscopic mass determination using photographic isodensity techniques.
AB  - Using Agfacontour, Kodalith, or similar films, it is possible to convert an
      electron micrograph into a map of regions of equal photographic density
      (isodensitites) by simple copying procedures. If images of polystyrene spheres 
      and a calibrated density wedge are included in the copies, it is possible to
      quantitatively calibrate the isodensities in terms of mass per unit area of the
      specimen. In this way, electronmicroscopic mass determination may be accomplished
      without the need of densitometers or other photometric equipment.

PMID- 1028188
TI  - Direct phase determination for quasi-kinematical electron diffraction intensity
      data from organic microcrystals.
AB  - Direct phasing techniques using cosine estimates for three-phase and four-phase
      structure invariants in space group P1 are applied to zonal hk0 electron
      diffraction intensity data from an orthorhombic paraffin and a cephalin. Ab
      initio use of these kinematical phases is shown to derive the correct structures
      of the methylene subcell packings for these compounds in agreement with earlier
      determinations from Patterson maps.

PMID- 1028189
TI  - Computer experiments for tilted beam dark-field imaging.
AB  - Simulated high resolution tilted beam dark-field electron micrographs for the
      conventional transmission microscope were obtained by performing wave optical
      calculations with a high speed computer. Various organometallic molecules and
      point defects in crystals were studied to assess whether the image structures
      resembled the orginal object in terms of atom positions and atom correlations for
      a variety of microscope conditions. For the organometallic molecules close
      agreement was found between actual experimental micrographs and calculated images
      for specific combinations of microscope parameters. The images of point defects
      indicate that it should be possible to identify these structures based upon image
      size and intensity which in turn are highly dependent on the strain field
      surrounding the defect.

PMID- 1028190
TI  - Quantitative tensile-tilting stages for the high voltage electron microscope.
AB  - This paper describes a soft and a hard tensile stage for the high voltage
      electron microscope. Both stages can be combined with a top entry double tilting
      stage. The devices are driven by thermal expansion elements operating against
      water cooled parts. The drive mechanism shows smooth action with a relatively low
      response time and good long-time stability. The stages are equipped with strain
      gauge bridges for force and elongation measurements. The soft stage has a maximum
      load of 13 g, and a hard one reaches 1.5 kg.

PMID- 1028191
TI  - The use of backscattered electrons for imaging purposes in a scanning electron
      microscope.
AB  - It is shown that the use of a very large detector for backscattered electrons can
      provide a signal comparable to that obtained in the secondary emission mode and
      that the resolution available is also comparable. A technique is described
      whereby the difference is taken between these two signals, and the use of this
      difference signal can significantly enhance surface details. It is believed that
      the use of such a signal should ultimately prove advantageous in increasing
      resolution.

PMID- 1028192
TI  - The formation and interpretation of defect images from crystalline materials in a
      scanning transmission electron microscope.
AB  - The technique of scanning transmission electron microscopy (STEM) has been
      employed usefully in studies of amorphous materials, and the theory of image
      formation and interpretation in this case has been well developed. Less attention
      has been given to the practical and theoretical problems associated with the use
      of STEM for the examination of crystalline materials. In this case the contrast
      mechanisms are dominated by Bragg diffraction and so they are quite different
      from those occurring in amorphous substances. In this paper practical techniques
      for the observation and interpretation of contrast from defects in crystalline
      materials are discussed. It is shown that whilst images of defects are obtained
      readily under all typical STEM operating conditions, the form of the image and
      the information it contains varies with the angle subtended at the specimen by
      the detector. If this angle is too large significant image modifications relative
      to the "conventional" transmission electron microscope case may occur and the
      resolution of the image may degrade. If this angle is too small, then signal to
      noise considerations make an interpretation of the image difficult. In this paper
      we indicate how the detector angle may be chosen correctly, and also present
      techniques for setting up a STEM instrument for imaging a crystalline material
      containing lattice defects.

PMID- 1028194
TI  - Report on EMAG75, a conference on developments in electron microscopy and
      analysis organised by the Electron Microscopy and Analysis Group of the Institute
      of Physics at the University of Bristol, UK, on the 8th-11th September 1975.

PMID- 1028193
TI  - The extension of scanning transmission electron microscopy by use of diffraction
      information.
AB  - The information contained in the intensity distribution of the convergent beam
      electron diffraction pattern, produced in the detector plane for each incident
      beam position in a scanning transmission electron microscope, may be used to
      enhance the resolution of the microscope or else to decrease the electron
      irradiation of the specimen involved in deducing information at any particular
      level of resolution. The structural information concerning the specimen may be
      obtained, for example by interpretation of the Patterson function using image
      seeking methods. The statistical error involved due to the finite number of
      electrons available may be derived by considering the efficiency of use of the
      information contained in Patterson function peaks. The most efficient means for
      using the available information appears to be that based on information theory
      concepts, which employ the integral over the product of the observed diffraction
      pattern intensity and the intensity calculated for known or postulated groupings
      of atoms. The reduction in radiation damage possible by use of this method,
      relative to that involved in the separate imaging of individual atoms, may be by
      a factor of approximately n, where n is the number of atoms in the known or
      postulated group being sought.

PMID- 1028195
TI  - Very low voltage electron microscopy.
AB  - We conclude that a 150 V scanning microscope with a resolution of 10 A is quite
      feasible and could have considerable value. It might consist of a field emission
      source, an electron gun to decelerate the electrons, a condenser lens to produce
      a parallel beam, a multipole corrector and a short focal length objective lens.
      Electrons reflected from the specimen surface would pass through a spectrometer
      whose principal features would be a large collecting power and low (1/200) energy
      resolution. Finally, we should add that such a microscope presents a considerable
      challenge and new opportunities for the electron optician in both lens and
      spectrometer design. We cannot refrain from pointing out that the Scherzer
      theorem does not necessarily hold for such a lens since the constraints of the
      theorem do not apply to this case.

PMID- 1028196
TI  - Hydrogen ion neutralization: a new contrast mechanism in the scanning
      transmission ion microscope.

PMID- 1028197
TI  - Enhancing the power of density modification.

PMID- 1028198
TI  - Computer programs and image analysis.

PMID- 1028199
TI  - Use of coincidence techniques to improve the detection limits of electron
      spectroscopy in STEM.
AB  - A method of improving the detection limits of microanalysis using electron energy
      losses due to inner-shell excitation is proposed. This is based on coincidence
      detection of the energy-loss electrons with another signal which also results
      from inner-shell excitations, i.e., Auger electrons or characteristic X-rays. It
      is concluded that there will be a significant improvement in the detection of
      monolayers on a homogeneous monatomic substrate by using coincidence of energy
      loss electrons with Auger electrons.

PMID- 1028200
TI  - Contribution of electron energy loss spectroscopy to the development of
      analytical electron microscopy.
AB  - The combined use of an electron energy loss spectrometer and an electron
      microscope provides some chemical information at the nanometer scale. The physics
      of the interaction processes between the incident electron beam and the thin
      sample foil is reviewed in terms of energy and momentum transfer. This analysis
      of the content of an electron energy loss spectrum allows us to establish rules
      for a satisfactory use of the information and to discuss the detection limits of
      this newly developed microanalytical technique.

PMID- 1028201
TI  - Quantitative electron probe microanalysis of biological thin sections: methods
      and validity.

PMID- 1028202
TI  - The study of the adsorption and diffusion of heavy atoms on light element
      substrates by means of the atomic resolution STEM.

PMID- 1028203
TI  - Radiation damage of proteins in the solid state: changes of amino acid
      composition in catalase.
AB  - Catalase has been irradiated with 100 keV electrons under conditions simulating
      the hazards of electron microscopic imaging. Amino acid analysis reveals a
      definite pattern of amino acid destruction which is well correlated with the
      particular chemical structures of amino acid side chains. This pattern appears to
      be distinctly different from the sensitivity pattern for monoamino acid systems,
      which fact is ascribed to intramolecular energy transfer and selective attack of
      liberated radicals.

PMID- 1028204
TI  - Low voltage electron microscopy--how low?

PMID- 1028205
TI  - Use of pure carbon specimen holders for analytical electron microscopy of thin
      sections.
AB  - The use of a simple specimen holder, made of pure carbon, for analytical electron
      microscopy of sections of biological material is reported. Interference of the
      specimen holder with the X-ray spectrum from the specimen is minimized. The
      contribution of the holder to the continuum spectrum is consistent with
      theoretical predictions.

PMID- 1028206
TI  - High resolution shadowing for electron microscopy by sputter deposition.
AB  - The sputtering process by an ion beam well collimated and highly accelerated
      provides a valuable means of high resolution shadowing, replication of a fine
      object by a combination of pre-shadowing and deposition as well as a preparation
      of supporting films. High resolution shadowing and films with grains smaller than
      1 nm can be obtained by argon ion-sputtering targets of tungsten and
      tungsten/tantalum alloy. The resolution of carbon replicas pre-shadowed with
      tungsten/tantalum is determined from the radius of curvature of replicated
      magnesium oxide crystal corners.

PMID- 1028207
TI  - Scanning transmission electron microscopy of thin specimens.
AB  - The intensity distributions in bright field and dark field images of thin
      specimens obtained in scanning transmission electron microscopy are evaluated in
      terms of the phase of object approximation for coherent and partially coherent
      illumination. Previous treatments, based on a weak phase object approximation are
      shown to contain unwarranted assumptions in some cases, resulting in predictions
      of limited validity. The probable errors due to the neglect of higher order terms
      in power series expansion and in the assumption that the dark-field signal from
      an annular detector is proportional to the total elastic scattering are
      evaluated. Questions of optimizing the signal intensity and contrast are examined
      by considering the detector configuration in relationship to the form of the
      convergent beam diffraction pattern formed in the detector plane and the
      implications for the use of diffraction pattern information to enhance the
      imaging process are considered.

PMID- 1028208
TI  - Measurement of focus and spherical aberration of an electron microscope objective
      lens.

PMID- 1028209
TI  - The modification of the electron microscope for special crystallographic
      applications.
AB  - The conversion of the transmission electron microscope to a convergent-beam
      camera and shadow microscope with facilities for experiments using two specimens
      located in different planes is discussed, with particular reference to older
      models such as the Elmiskop 1. The conversion requires the removal of the
      intermediate lens in some microscopes and thus prevents them from operating in
      their original capacity. The Elmiskop 1 has a wide intermediate lens pole-piece
      which does not unduly restrict the diffraction angle. The smallest crystal
      spacing contributing to the convergent-beam diffraction pattern is 0.05 nm.

PMID- 1028210
TI  - Minimization of dose as a criterion for the selection of imaging modes in
      electron microscopy of amorphous specimens.
AB  - A fundamental limitation in electron microscopy of organic specimens is radiation
      damage by the electron beam. To minimize damage it is necessary to have maximum
      information collection for a given dose. Various modes of operation of
      conventional and scanning transmission microscopes are compared with respect to
      their ability to detect small changes in specimen thickness or density with a
      given signal to noise ratio. Incoherent imaging is assumed, and this is expected
      to apply to amorphous specimens under a variety of microscope conditions. For
      either very thin or very thick specimens, the scanning transmission microscope is
      found to require nearly 10 times less dose than a conventional microscope for the
      same signal to noise ratio in the image. For specimens of intermediate thickness,
      scanning and conventional transmission electron microscopes are roughly
      equivalent.

PMID- 1028211
TI  - Influence of detector geometry on image properties of the STEM for thick objects.
AB  - Plural electron scattering within thick objects broadens and smoothes the
      intensity distribution in the detector plane of a scanning transmission electron
      microscope. Detector arrangements have been determined which give maximum
      contrast and optimum S/N when the object details are large compared to the
      scanning spot. Asymptotic expressions for the optimum detector angles, specimen
      resolution, and S/N were obtained which are valid for objects thicker than
      approximately four elastic mean free path lengths. Exact calculations of the
      changes in contrast and S/N with thickness fluctuations in amorphous carbon foils
      were performed for atbitrary foil thicknesses. Elastic and inelastic electron
      scattering was taken into account.

PMID- 1028212
TI  - Report of a workshop on analytical electron microscopy held at Cornell
      University, Ithaca, New York, USA, August 3-6, 1976.

PMID- 1028213
TI  - Genetic leukodystrophies.

PMID- 1028214
TI  - Cesarian section and the risk of neonatal intracranial hemorrhage.

PMID- 1028215
TI  - Ependymal neoplasms in children.

PMID- 1028216
TI  - Childhood heartburn mimicking neuropsychiatric disease.

PMID- 1028217
TI  - Kearns-Sayre syndrome or ophthalmoplegia-plus? To lump or to split?

PMID- 1028218
TI  - Eosinophilic polymyositis.

PMID- 1028219
TI  - Myopathic fibrillation potentials and collateral innervation in the human
      myopathies.

PMID- 1028220
TI  - Immobilization and muscle atrophy.

PMID- 1028221
TI  - Amyloid polyneuropathy--a plasma cell dyscrasia with abnormal circulating
      immunoglobulins.

PMID- 1028222
TI  - Central and peripheral nervous system degeneration produced by pure n-hexane.

PMID- 1028223
TI  - The large apparent metabolic work capacity of the blood-brain barrier.

PMID- 1028224
TI  - Hypothesis for rational therapy in acute stroke.

PMID- 1028225
TI  - Elevated antidiuretic hormone levels after cerebrovascular accidents.

PMID- 1028226
TI  - Some determinants of vestibular canal activity in cat and man.

PMID- 1028227
TI  - New, noninvasive test for late-onset acid maltase deficiency: assay of urinary
      enzyme.

PMID- 1028228
TI  - Acid maltase deficiency: reincarnation in cultured muscle fibers of the typical
      morphological and biochemical defects.

PMID- 1028229
TI  - The characterization of human peripheral nerve collagens.

PMID- 1028230
TI  - Effect of ammonia on cerebral metabolism of rats with portocaval shunts.

PMID- 1028231
TI  - Regulation of intracranial pressure in rat, dog, and man: manometric assessment
      of cerebrospinal fluid dynamics using a constant-flow perfusion system.

PMID- 1028232
TI  - Use of a self-administered questionnaire for detection of TIA in elderly
      populations--an interim report.

PMID- 1028233
TI  - Cortical unit activity during generalized seizures induced by penicillin.

PMID- 1028234
TI  - Endogenously released adenine derivatives: a possible role in epileptogenesis.

PMID- 1028235
TI  - Mesocortical dopamine projections: the septal innervation.

PMID- 1028236
TI  - A clinical pharmacology of eterobarb: a gas chromatographic--mass spectrometric
      study.

PMID- 1028237
TI  - Experimental models of metastases to the nervous system.

PMID- 1028238
TI  - Brain tumor chemotherapy: translation of laboratory experiments into clinical
      trials.

PMID- 1028239
TI  - Chemotherapy of malignant glioma with CCNU alone and CCNU combined with
      vincristine sulfate and procarbazine hydrochloride.

PMID- 1028240
TI  - St. Louis Encephalitis (SLE) in a middle-class population in Northern Illinois.

PMID- 1028241
TI  - Myxedema myopathy and myasthenia.

PMID- 1028242
TI  - Optic gliomas of multicentric origin with favorable response to radiotherapy.

PMID- 1028243
TI  - Dendritic changes in the aging human rhinencephalon.

PMID- 1028244
TI  - Age as a determinant in the neurology of subdural hematomas.

PMID- 1028245
TI  - Static and progressive neuromuscular disease in a kindred.

PMID- 1028246
TI  - Charcot joints associated with normal cutaneous sensation.

PMID- 1028247
TI  - Focal lesions of muscle in peripheral vascular disease: their comparison with
      Duchenne muscular dystrophy.

PMID- 1028248
TI  - Myocardial damage and cardiac arrhythmias in cerebral infarction and subarachnoid
      hemorrhage: correlation with increased systemic catecholamine output.

PMID- 1028249
TI  - Sequence of myelination in the human fetus.

PMID- 1028250
TI  - Korsakoff syndrome resulting from bilateral fornix lesions.

PMID- 1028251
TI  - The effects of osmotic gradients on fluid movement through brain and on choroid
      plexus secretion in experimental hydrocephalus.

PMID- 1028252
TI  - Involuntary movements of the upper limbs in cervical myelopathy as part of
      flexion withdrawal.

PMID- 1028253
TI  - Familial amyotrophic lateral sclerosis.

PMID- 1028254
TI  - Electrophysiological study of anomalous innervation of intrinsic hand muscles.

PMID- 1028255
TI  - Morphologic abnormalities in cerebellar biopsies of epileptic patients.

PMID- 1028257
TI  - A growth model for the total weight of the prenatal human brain.

PMID- 1028256
TI  - Progressive dialysis encephalopathy: clinical EEG, and neuropathologic features.

PMID- 1028258
TI  - Environmental factors modifying the effect of CCNU on glioma in vitro and in
      vivo.

PMID- 1028259
TI  - Herpesvirus and multiple sclerosis.

PMID- 1028260
TI  - The prevalence of epilepsy in a large heterogeneous urban population (The Bronx,
      New York, January 8, 1975).

PMID- 1028261
TI  - Thalamic hemorrhage with speech disorder.

PMID- 1028262
TI  - Thymoma with distant metastases.

PMID- 1028263
TI  - Epileptogenesis in mammalian cortex studied in vitro.

PMID- 1028264
TI  - Antimyelin basic protein antibodies and cellular hypersensitivity in multiple
      sclerosis.

PMID- 1028265
TI  - The diving reflex in infants: a preliminary report.

PMID- 1028266
TI  - Brainstem auditory potentials in clinically diagnosed central pontine
      myelinolysis.

PMID- 1028267
TI  - Experimental stroke in gerbils: selective vulnerability at the molecular and
      cellular levels.

PMID- 1028268
TI  - Changes in ammonia and amino acid metabolism induced by hyperosmolality in vivo
      and in vitro.

PMID- 1028269
TI  - Myelin basic protein in cerebrospinal fluid as an indicator of active
      demyelination.

PMID- 1028270
TI  - Sequential parkinsonism and chorea following "mild" inluenza.

PMID- 1028271
TI  - Quantitative analysis of the ocular motor deficit in progressive supranuclear
      palsy (PSP).

PMID- 1028272
TI  - Psychological deficits and recovery of functions after head injury.

PMID- 1028273
TI  - Autosomal dominant striatonigral degeneration: a clinical, pathological, and
      biochemical study of a new genetic disorder.

PMID- 1028274
TI  - Progressive multifocal leukoencephalopathy: clinical pathological correlates and
      failure of a drug trial in two patients.

PMID- 1028275
TI  - New histochemical technique for the demonstration of adenyl cyclase (AC) in
      nervous tissue and muscle.

PMID- 1028276
TI  - X-linked recessive humero-peroneal neuromuscular disease associated with atrial
      paralysis and sudden death.

PMID- 1028277
TI  - Fine structural changes in the cerebellar cortex in kinky hair disease.

PMID- 1028278
TI  - Endotoxin encephalopathy.

PMID- 1028279
TI  - Disease nomenclature and classification systems in neurologic practice, research,
      and education.

PMID- 1028280
TI  - Brain sarcomas.

PMID- 1028281
TI  - Quantitative cinemorphology of the human brain displayed by means of mobile
      computer graphics.

PMID- 1028282
TI  - [Veterinary service to dairy farms in the Democratic Republic of Germany].

PMID- 1028283
TI  - [The veterinary physician as an inventor].

PMID- 1028284
TI  - [Effect of microclimate on the heifer organism].

PMID- 1028285
TI  - [Resistance and productivity swine in relation to rate of air circulation].

PMID- 1028286
TI  - [Simultaneous immunization of cattle against infectious bovine rhinotracheitis].

PMID- 1028287
TI  - [Age-related bactericidal activity of the blood serum of calves].

PMID- 1028288
TI  - [Treatment of calves with bronchopneumonia].

PMID- 1028289
TI  - [Effectiveness of ampicillin in pullorosis-typhoid of chickens].

PMID- 1028290
TI  - [Trout diseases in fish ponds].

PMID- 1028291
TI  - [Strains and species of Trichinella and their role in the epizootiology of swine
      trichinosis].

PMID- 1028292
TI  - [Control of sarcoptidosis in swine].

PMID- 1028293
TI  - [Sanguinicoliasis in young carp].

PMID- 1028294
TI  - [Parasitic fish diseases in the Dnieper water reservoirs].

PMID- 1028295
TI  - [Bothriocephaliasis in carp].

PMID- 1028296
TI  - [Condensed calving and prevention of sterility of cows].

PMID- 1028297
TI  - [Fat cells in diseases of the reproductive organs of cows].

PMID- 1028298
TI  - [Histochemistry of nonspecific phosphatases in the bovine uterus].

PMID- 1028299
TI  - [Use of spermosan-3 before the insemination of mares].

PMID- 1028300
TI  - [Aerosols of drugs of bronchopneumonia].

PMID- 1028301
TI  - [Increase in the degree of general nonspecific resistance of young pigs].

PMID- 1028302
TI  - [White muscle disease of chickens].

PMID- 1028303
TI  - [Indicators of the resazurin test in sanitary analysis of milk].

PMID- 1028304
TI  - [Effect of preparation PV-1 on pork quality].

PMID- 1028305
TI  - [Detection of salmonellae in the organs of swine].

PMID- 1028306
TI  - [Laboratory diagnosis of avian influenza].

PMID- 1028307
TI  - [Use of disc electrophoresis in veterinary practice].

PMID- 1028308
TI  - [Professional orientation of students in veterinary medicine].

PMID- 1028309
TI  - [Graduate training of specialists in veterinary medicine].

PMID- 1028310
TI  - O.R. exposure--cancer, miscarriages, and birth defects.

PMID- 1028311
TI  - Respiratory disease in beauticians.

PMID- 1028312
TI  - Litigation involving DES.

PMID- 1028313
TI  - Home delivery research today--a review.

PMID- 1028314
TI  - The swine flu immunization program.

PMID- 1028315
TI  - Homer G. Phillips: historic training hospital for black physicians may pass from
      the scene.

PMID- 1028316
TI  - Primary care: a definition.

PMID- 1028317
TI  - Study in Watts. Family practice for the inner city: what consumers expect.

PMID- 1028318
TI  - Organization for primary care training in the teaching hospital.

PMID- 1028319
TI  - Case-finding for chronic illness in a black community.

PMID- 1028320
TI  - "If we want GPs, we'll have to admit them to medical school".

PMID- 1028321
TI  - Today's challenges in primary health care.

PMID- 1028322
TI  - New York hospitals get new guidelines for patient research.

PMID- 1028323
TI  - Family practice: a need for research.

PMID- 1028324
TI  - Symposium discusses cardiovascular diseases: emphasis on black community.

PMID- 1028325
TI  - Estimation of the Ca2+ binding by microsomal membranes from pig coronary artery
      using a calcium ion selective electrode.
AB  - To estimate the Ca2+ binding of microsomal membranes from pig coronary artery a
      modified potentiometric method was used. With this method it was possible to
      follow directly changes in the Ca2+ ion activity of the incubation medium down to
      10(-8) moles. Compared with the Ca45-filter technique the electrometrically
      measuring device built up was beside the obvious advantages of a directly
      indicating method more fast, simple and hightly sensitive.

PMID- 1028326
TI  - [Insulin catabolism by transformed, cultivated mouse fibroblasts (L-cells)].
AB  - Cultivated, transformed mouse fibroblasts (L-cells) are endowed with enzyme
      systems for insulin breakdown that are comparable to those of many other types of
      non-dedifferentiated insulin target cells (time and substrate dependence, Km
      value). It cannot yet be decided, however, which of the potential enzyme systems
      (thiolproteindisulfide-oxidoreductase (TPO) [E.C. 1.8.4.2] or proteinase) is
      prevalent in insulin breakdown in intact L-cells. Despite the lack of typical
      target symptoms for insulin, the cultivated L-cell could provide an appropriate
      experimental model for the insulin metabolism.

PMID- 1028327
TI  - [Quantitative analysis of absorption spectra and spectra of magneto-optical
      rotatory dispersion of hemoproteins with reference to zero-field splitting. I.
      Analysis of the divalentcation of deuteroporphyrin in the Q-band region].
AB  - I. Analysis of the dication of deuteroporphyrin in the Q-band region. Methods for
      quantitative analysis of absorption spectra and magneto-optical rotatory
      dispersion with regard to zero-field splitting of a nearly degenerated term for
      the latter are described. The methods are based on adaptation of band-form
      functions to the spectrum using the principle of least squares. Calculation of
      the zero-field splitting utilizes the formalism evolved by Stephens for strictly
      degenerated terms (A-terms in the magneto-optical spectrum) which has been
      further developed to a band-form function depending on zero-field splitting. The
      curve-form function of the modified A-term contains 4 parameters (zero-field
      splitting, rotational strength, band width, and the maximum of the band) which
      have been determined by a computer program. The oscillator and the dipole
      strength of absorption bands to be calculated simultaneously with the program
      allows the determination of the magnetic orbital moments of the terms.
      Exemplified by the dication of deuteroporphyrindimethylester, the significance of
      zero-field splitting for the recognition of the exact molecule symmetry is
      demonstrated, and a model of the molecular structure is proposed.

PMID- 1028328
TI  - Seasonal reproductive periodicity and thyroid fluctuations in female Indian palm
      squirrel, Funambulus pennanti.
AB  - Seasonal reproductive rhythmicity and concomitant thyroid fluctuations have been
      studied in the female Indian palm squirrel, Funambulus pennanti. The majority of
      the squirrels enter estrus during March and April when ovarian follicles attain
      maximum diameter. Ovulation starts in April and continues till June. A large
      number of degenerating follicles, indicating decline in ovarian functions, is a
      characteristic feature of the ovary in August. Minimum percent thyroid 131I
      uptake is recorded during May and June, i.e. at the onset of mating season. In
      July, which also marked the gestation period in the majority of the squirrels
      dissected, thyroid activity significantly increases. Gonadal regression begins in
      August and this is accompanied by corresponding fall in the thyroid 131I uptake.
      Alterations in thyroid cytoarchitecture during different months of the year are
      in accordance with the results obtained from radioiodine uptake studies.
      Fluctuations in thyroid functions during gonadal regression, recrudescence and
      peak gonadal activity are discussed in the present communication.

PMID- 1028329
TI  - Folding crystallization of DNA. Circular dichroism studies.
AB  - CD spectra of DNA monocrystals are extremely different from spectra of psi-DNA or
      DNA-histone H1 or DNA-polylysine complexes. They are discussed to be dependent on
      the supramolecular organization of DNA in the condensed form, and they are not in
      contradiction to the previously proposed seven folding model of DNA in chromatin.
      Conclusions are drawn with regard to the interpretation of chromatin CD spectra.

PMID- 1028330
TI  - [Action of several respiration inhibitors on the tetramethyl-p-phenyldiamine
      short-circuit pathway in nonphosphorylating electron transport particles in the
      bovine heart].
AB  - Non-phosphorylating electron transfer particles from beef heart according to
      CRANE et al. possess the ability to oxidize succinate via the artificial TMPD
      bypass of the respiratory chain. The respiratory inhibitors TTFA, carboxin,
      tridemorph and the inhibitory protein RF from rabbit reticulocytes act both on
      the normal succinate oxidase and on the bypass. The presence of antimycin A
      diminishes the inhibition of carboxin on the bypass, likely by way of the
      increase of the degree of reduction in the iron-sulphur proteins. The inhibition
      by an isatin-beta-isothiosemicarbazone acting on the complex III of the succinate
      oxidase system is relieved by TMPD analogous to antimycin A.

PMID- 1028331
TI  - [Effect of bis-(p-chlorophenoxy) acetic acid on serum lipids].

PMID- 1028332
TI  - [Cochlear implants].

PMID- 1028333
TI  - ENG and the cervical syndrome. Neck torsion nystagmus.

PMID- 1028334
TI  - [Facial paralysis: diagnosis and treatment].

PMID- 1028335
TI  - [Chronic atrophying polychondritis].
AB  - A case of chronic atrophic polychondritis in a 75 year old female patient is
      reported. The disease started with an asymptomatic lesion of the nasal septum. It
      was diagnosed after involvement of the auricular cartilages, which was followed
      by an ocular and then by a tracheal symptomatology. A histological study by means
      of optical microscopy and of electronic microscopy is presented. The general
      characteristics of chronic atrophic polychondritis are given. It is a systemic,
      inflammatory disease, and progresses by successive outbreaks. Its gravity lies in
      the frequency of laryngeal and tracheo-bronchial lesions. Its pathogeny is
      unknown. Two hypotheses are considered: the first, that it is due to a
      disturbance in the metabolism of mucopolysaccharides ; the second is based on an
      immunological mechanism.

PMID- 1028336
TI  - [Electronystagmographic effects of oculomotor involvement].

PMID- 1028337
TI  - [Profile of deaf children].

PMID- 1028338
TI  - [Schirmer's test in the intratemporal surgery of the facial nerve].
AB  - The Schirmer test enables us to localise a lesion of the facial nerve as situated
      proximally or distally to the geniculate ganglion. Three cases of traumatic
      facial paralysis were surgically treated. One by transmastoidal decompression,
      two others by subtemporal suture or nerve graft. Partial to subtotal
      reinnervation took place in all three cases. The correct choice of transmastoidal
      or subtemporal approach was made according to the results of the Schirmer test,
      in the absence of X ray information.

PMID- 1028339
TI  - [Microsurgery in the treatment of larygneal dysplasia].

PMID- 1028340
TI  - [Passage into normal salivary, lacrimal and nasal secretions of ampicillin and
      erythromycin administered intramuscularly].
AB  - The authors have measured, with the agar diffusion technique, the antibiotic
      concentrations in the serum as well as in the normal nasal, lachrymal and
      salivary secretions, after an intramuscular injection of 500 mg of ampicillin and
      of 200 mg of erythromycin. Bacillus subtilis is used as test germ for dosage of
      ampicillin and Sarcina lutea for the dosage of erythromycin. An important
      quantity of ampicillin (0.5 to 2.5 microgram/ml) passes into the nasal secretion.
      Its passage into the saliva is very irregular and is usually very slight.
      Bacillus subtilis is not suitable for systematically studying the ampicillin
      concentration in the lachrymal secretion, which displays a strong, inherent
      inhibitory effect on this micro-organism. Important concentrations of
      erythromycin are found in the three secretions: 0.5 to 3.25 microgram/ml in the
      nasal mucus and in the lachrymal secretion, 0.3 to 4.5 microgram/ml in saliva.

PMID- 1028341
TI  - [Clinical consideration on suicide].

PMID- 1028342
TI  - [The family of the alcoholic woman].

PMID- 1028343
TI  - [The problem of guilt in the Freudian model of man].

PMID- 1028344
TI  - [Study of 100 manic depressive patients: I. Retrospective evaluation of their
      treatment with lithium; various aspects of the natural history of the disease].

PMID- 1028345
TI  - [Myobiidae of Insectivora with descriptions of new taxa (Acarina: Prostigmates)].

PMID- 1028346
TI  - [Note on several Turbinoptidae of Europe, Asia and America (Acarina:
      Astigmates)].

PMID- 1028347
TI  - Pulmonary alveolar microlithiasis in the orang-utan (Pongo pygmaeus).
AB  - A 19-years-old male Orang-Utan had a brief illness of two weeks with marked
      dyspnoea. Necropsy revealed diffuse bilateral pulmonary alveolar microlithiasis.
      This is the first account of this pathoanatomical entity in lower primates.

PMID- 1028349
TI  - Pharmacy practice and pharmaceutical education in the People's Republic of China.

PMID- 1028348
TI  - A review of the diets of captive gorillas (Gorilla gorilla).
AB  - It is clear that most zoos feed their gorillas a principally frugivorous diet,
      while the diets of wild gorilla populations are undoubtedly basically
      herbivorous. The primary food plant of western and eastern lowland gorillas is
      Aframomum, and Blancou (1955) even maintains that these plants possess active
      parasiticidal qualities, but this subscription is not borne out by recent
      research. However, it is possible that another plant food, combretum, could have
      some propensities as a deparasitant. Many captive gorillas accept cooked or raw
      meat in their diets and there is some evidence that feral gorillas may also
      occasionally consume matter of animal origin.

PMID- 1028350
TI  - Linking career choice to personality types: a preliminary analysis of pharmacy
      students.

PMID- 1028351
TI  - Pharmacy students revisited as pharmacists.

PMID- 1028352
TI  - A learning hierarchy for a course in drug analysis.

PMID- 1028353
TI  - Adaptation of Flanders' interaction analysis to assist in developing
      communication skills in final-year pharmacy students.

PMID- 1028354
TI  - Evaluation of a continuing education course for temporarily nonpracticing
      pharmacists.

PMID- 1028355
TI  - Demographic study of the relationship of continuing pharmaceutical education to
      selected attitudinal- and competence-related criteria.

PMID- 1028359
TI  - A perspective on relevance in pharmaceutical education.

PMID- 1028358
TI  - A theoretical model for faculty "peer" evaluation.

PMID- 1028360
TI  - Continuing education as a life-long process.

PMID- 1028361
TI  - Lessons for pharmacy: observations and continuing education experiences on a
      state examining board for nursing home administrators.

PMID- 1028362
TI  - [Validity of nutrition survey methods].
AB  - The aim of all dietary surveys is to discover what the persons under
      investigations are in habit of eating. They could be used to collect data on a
      single individual and on several hundred of individuals. There are two types of
      methods used: --evaluation of global consumption, --precise dietary studies.
      Additional studies research conscious and unconscious factors of dietary
      consumption. Whatever the aim, dietary patterns are used to trace trends both
      retrospectively and prospectively. But the nutritionist must be aware of
      limitations of the methods and be constantly improving them. It is imperative,
      therefore, that critical evolution be made at every stage of the procedure. The
      interest of those studies is to identify the current nutrient intake of a group
      or an individual likewise during a longer period, so that we can define the
      evoluation and perhaps the reason behind them. In epidemiological work, they are
      a part of the whole given data. They could permit the evaluation of correlation
      with clinical or biological parameters or with a particular disease.

PMID- 1028363
TI  - [Development of carbohydrate and sucrose consumption among the French
      population].

PMID- 1028364
TI  - [Lipid consumption of the French population (1965-1974)].

PMID- 1028365
TI  - [Development of human consumption of proteins in France during the past ten years
      (1965-1974)].
AB  - A rapid development in the alimentary comportment has been primarily due to
      socioeconomic and physico-sensorial factors. Protein consumption by the French
      population has modified over the past years. Even though the average ration is
      high and stable, approximatly 100 grams per day, protein malnutrition still
      exists. Actually, 16 p. 100 of the aged population, with moderate revenue,
      consume less than 45 grams of protein per day. Vegetal protein consumption over
      the last ten years has dropped by 14 p. 100 from 41,7 grams to 35,8 grams of 36
      p. 100 of the total. A decline in the consumption of tender wheat down 20 p. 100
      in ten years, is responsible for this reduction. Animal proteins represent 64 p.
      100 of the ration protein which is a 10 p. 100 increase. However, the milk ration
      has dropped radically by less than 50 p. 100 during this same ten year period.
      This is compensated by an increase in cheese consumption, up 25 p. 100 and meat
      being more often purchased also up 15 p. 100. In the French population the
      protein ration is high and contains an overabundance of animal proteins
      associated with a high degree of saturated animal fats. Further studies must be
      made to permit a more precise evaluation of these consequences on public health
      and related industries in the alimentary field.

PMID- 1028366
TI  - [Food consumption of adults in France].

PMID- 1028367
TI  - [Dietary behavior of the French child].
AB  - For 0 to 1 year old children, breast feeding represents a perfect reference. From
      the composition of maternal milk and the amount taken by a well developing child,
      some precise data can be drawn. These data were, in fact, utilized for preparing
      the maternized milks which must be, to-day the only substitute for human milk
      when, for any real reason, a mother is not able to feed her own baby. For older
      children and for adolescents, the data are incredibly rare. The few inquiries now
      available show some concordance on calories, glucides and lipides, but diverge
      strongly on proteins and calcium requirement. This lack of information does not
      seem to embarrass much physicians and dieticians in prescribing some measured
      diets to their patients; but, from a scientific point of view, this absence of
      data prevents strongly from understanding the studies made, for instance, on
      spontaneous diet in diabetic or obese children. A coordinated study, using
      revised nutritional tables, should be undertaken.

PMID- 1028368
TI  - [Effect of external stimuli on the effectiveness of the adipostat].

PMID- 1028369
TI  - [Dietary behavior as a social act and socialization factor].

PMID- 1028370
TI  - [Psycho-socioeconomic relations within consumption systems].

PMID- 1028371
TI  - [A non-receptive hunger].
AB  - The Psychopathology of Anorexia mentalis offers the main and singular interest to
      understand how hunger is a need and no aliementar response can suffice. The
      recent contributions of psycho-analysis give central significations of the food
      relation between mother and baby. The symbolic importance of this relation is
      determinant in the normal behaviour.

PMID- 1028372
TI  - [The rule of dietary practices].

PMID- 1028373
TI  - [Culinary art and civilization: some reflections].

PMID- 1028374
TI  - [Economic and social determinants of food cost over a long term: diet of city
      laboring families].

PMID- 1028375
TI  - [Dietary behavior and constraint by cost].
AB  - After the Second World War, it had become clear that consumers often use the
      price of a products as an indication to its quality, and the classical economy
      Homo Economicus'rationalism was often questioned, for that and other reasons,
      within the context of the Affluent Society. Today, we may be witnessing a return
      to rationalism. But it may still be more of a lip service rationalism than a
      behavioural one. Two studies are presented where housewives responded much more
      negatively "in words" (in their intended purchases, as stated in a survey) that
      "in fact" (in actual purchasing), when faced with a price increase of food
      commodities. The actual purchases were assessed by a controlled experiment using
      15 supermarkets. The experiment, designed into a latin square, lasted three
      months. Four price levels were tested: normal, +20%, -10% and -20%. The
      intentions-to-buy were assessed by interviewing (at home) customers of the same
      supermarkets, during the experiment, and asking them whether they would buy the
      product at each of the four price levels, under experimentation.

PMID- 1028376
TI  - [Production of anti-Aeromonas salmonicida agglutinins by the rainbow trout.
      Influence of temperature, an adjuvant and an immunosuppressive agent].
AB  - Adult rainbow trout were immunized intraperitoneally with a chloroform killed
      Aeromonas salmonicida suspension. Agglutinating antibodies were titrated using a
      microtiter system. Antibody activity was associated with IgM fraction obtained
      from Sepharose 4 B gel filtration. The kinetics of antibody formation were
      established at three temperatures. At 50C detectable antibodies were found at day
      50 post immunization. At 10degrees C and 16 degrees C the agglutinin titer rose
      before day 20. The antibody titer was significantly raised by Freund's complete
      adjuvant, but cyclophosphamide at a total dose of 500 mg/kg of body weight
      administered in 10 injections before and after immunization had no effect.

PMID- 1028377
TI  - [Biometry, hematology, blood biochemistry, blood and tissue enzymology of the
      gray partridge (Perdrix perdrix)].

PMID- 1028378
TI  - Variations in some plasma metabolites from neoglucogenesis and ketogenesis in
      pregnant ewes in relation to diet.

PMID- 1028379
TI  - The effects in the rabbit, of hepatic coccidiosis on the digestibility of fat and
      energy.

PMID- 1028380
TI  - Swine fever: influence of passive immunity on pig immune response following
      vaccination with a live virus vaccine (Thiverval strain).
AB  - The influence of passive immunity on the immune response to swine fever virus
      (S.F.V.) was investigated in pigs injected with variable amounts of S.F.V.
      antibodies instead of piglets from immune sows. The passive immunity suppresses
      the primary serum antibody response normally observed after vaccination with the
      Thiverval strain of S.F.V. This inhibition is either partial or complete
      depending on the amount of injected antibodies. Whatsoever the passive immunity
      intensity, a priming occurred (even in absence of any detectable primary
      response). This priming was evidenced by the clinical signs and the type of
      immune response following a virulent challenge. Two vaccination routes were
      tested: intramuscular and intranasal: 48 pigs were checked and no significant
      differences established, concerning protective efficiency. Intranasal vaccination
      induced local antibody production in pharyngeal secretions. Even in the absence
      of any detectable immunoglobulin transudation from serum to these secretions,
      local antibody synthesis was completely inhibited in passively immunized animals.

PMID- 1028381
TI  - [In vitro culture of a rotavirus associated with neonatal calf diarrhea].
AB  - About fifty diarrheic fecal samples in which the calf rotavirus was present in
      variable quantities were passed in tissue cultures and the ability of the virus
      to replicate was analysed under different experimental conditions by means of an
      indirect immunoflourescent test. Several cell species were shown to be
      susceptible to the virus but the best results were obtained in primary or
      secondary cultures of embryonic calf kidney cells in presence of maintainance
      medium containing 2 to 4 p. 100 foetal calf serum or chick serum. The specific
      infectivity of this type of virus is low in tissue culture. Under the best
      experimental conditions about 70 p. 100 of the samples that were positive for the
      virus by electron microscopy, induced the appearance of specifically fluorescent
      cells. Cytopathic effects due to infection are extremely discreet and most often
      there is no evidence of transfer of infection from cell to cell. Different
      attempts to adapt the infective agent to grow in tissue culture finally succeeded
      in the selection of a virus that was able to induce fluorescnet plaques at the
      fifth pass.

PMID- 1028382
TI  - [Demonstration of a protocol for obtaining germ-free chickens].
AB  - A simple and reliable technique for obtaining germ-free chickens was
      investigated. Various disinfection tests of the material and the eggs have been
      performed with chemical agents. The weak frequency of internal contamination of
      the eggs (0.4 p. 100), if collected in good hygienic conditions and dipped the
      same day in a I per 100 solution of mercuric chloride, allows sterile hatchings
      in 100 fertilized eggs batches to be obtained. The sterilization of the isolator
      hatching box was performed by pulverization of a I per 100 solution of quaternary
      ammonium, followed by a formaldehyde fumigation. The material passed through an
      antiseptic bath (liquid-lock) of I per 100 quaternary ammonium in water. This
      technique yielded 250 chickens, in 12 successive lots, that were bred until 15
      days to 6 weeks, without bacteriological contamination.

PMID- 1028383
TI  - [Epidemiologic methods in environmental hygiene. Air pollution].

PMID- 1028384
TI  - [Improvement of the microbiologic quality of vaccine].

PMID- 1028385
TI  - [Encephalopathy caused by ingestion of bismuth salts].

PMID- 1028386
TI  - [Actualities on the epidemiology, prophylaxis and serological diagnosis of
      toxoplasmosis (author's transl)].

PMID- 1028387
TI  - [Epidemiology of rubella during 1971-1975. Comparison with abortus cases and
      malformed newborn in Lombardia (Italy) (author's transl)].
AB  - Details regarding claims of rubella occurred in Lombardia (Italy) have been
      collected by the AA., in force at the Regional Health Services. The results have
      been also compared with the claimed cases of abortus and of malformed newborn.
      The first results of voluntary vaccination, promoted by the Regional Services,
      both on children of the 5th Classes of Primary School and on women more exposed
      to risks provoked by rubella infections are also reported.

PMID- 1028388
TI  - [Determination of the cercarial lipids and relations with superficial human
      cutaneous lipids (author's transl)].
AB  - The lipid class composition of cercariae of Schistosoma mansoni and skin surface
      has been examined by thin lager chromatography. Free sterols, sterol esters,
      triglycerides, phospholipids were major components of cercarial lipids,
      triglycerides, wax esters, free fatty acids, squalen were major components of
      skin surface lipids. An examination of fatty acids of total cercarial and skin
      surface lipids revealed that C16, C18, C18=, C16=, C18= were major components.

PMID- 1028389
TI  - [Statistical and epidemiological on the incidence of salmonellosis in
      Valdinievole's district (author's transl)].
AB  - The Author, on the basis of the data of his Laboratory in Pescia's Hospital, put
      in evidence the diffusion of the endemic state due to Salmonella in his district
      and calls competent authority's attention for a greater conscience of this
      problem, so as to embank a situation that, controlled efficaciously, could cause
      epidemical episodes like those happened in other zones of our Country.

PMID- 1028390
TI  - [Blocking antibodies after specific hyposensitization therapy in asthmatic
      children (author's transl)].
AB  - The Maunsell-test for the evaluation in vivo of a rise in blocking antibodies
      after specific hyposensitization therapy was perfomed in 27 children with asthma
      and/or graminaceous rhinitis. The Authors have found a good correlation between
      blocking antibodies level and clinical improvement.

PMID- 1028391
TI  - Uptake, accumulation and loss of 60Co in some species of mycobacteria.

PMID- 1028392
TI  - [Cognitive correlates of pleasure of visual complexity].

PMID- 1028393
TI  - [A sequential decision model for optimizing psychotherapeutic conversations].

PMID- 1028395
TI  - Nonmetric multidimensional scaling without disparities and derivatives: a
      rankcorrelation-orientated approach through L1-approximation.

PMID- 1028394
TI  - [Factor analysis, rotation problem and implications for test construction.
      Optimal rotation procedure with empirical data (FPI)].

PMID- 1028397
TI  - Spurious correlation, revisited: a new look at the quantitative outcomes of
      sampling heterogeneous groups and/or at the wrong time.

PMID- 1028396
TI  - [Functional measurements and cognitive algebra. A critical methodological
      contribution for deciding between models of information integration. Part I:
      diagnosis of combination rules from paired comparisons].

PMID- 1028398
TI  - [Mathematical adjustment: impracticability of methods of linearization for
      adjusting of potential and exponential functions].

PMID- 1028399
TI  - Hodgkin's disease: an evaluation of staging laparotomy in 82 patients.

PMID- 1028400
TI  - Dilatation of azygos vein simulating mediastinal tumour.

PMID- 1028401
TI  - Pneumothorax as a complication of radiation therapy for primary lung cancer.

PMID- 1028402
TI  - Ewing's tumour of rib.

PMID- 1028404
TI  - Liver studies with radioisotopes.

PMID- 1028403
TI  - A look at bone.

PMID- 1028406
TI  - Open University course on environmental control and public health.

PMID- 1028405
TI  - A radiochromatographic method for biliary contrast agent metabolites.

PMID- 1028407
TI  - The application of Steinbuch's "Lernmatrix" as a new mathematical approach in the
      assessment of air pollution effects.

PMID- 1028408
TI  - Teletransmission of physiological data.
AB  - The routine procedure of EEG recording is recalled to show the advantages of
      telemetric assessment of this parameter. The procedure for EEG telemetry is shown
      under different circumstances, e.g., by transmission with the aid of the
      'Community Antenna System' of a hospital. Finally, a 16-channel telemetry system,
      using pulse width modulation is described.

PMID- 1028409
TI  - Calibration and measurement in 3-dimensional monitoring of human motion by
      optoelectronic means. II. Experimental results and discussion.

PMID- 1028410
TI  - A 4-channel telemetry system for hospital patient monitoring.
AB  - A 4-channel radio telemetry system has been designed and implemented for use in
      the operating room on patients undergoing surgery. 30 such systems are in daily
      use throughout the Duke University Medical Cener. Relative simplicity, long
      battery life and a DC-response capability are the important features of these
      systems. The four physiological channels used are; electroencephalogram,
      electrocardiogram, peripheral pulse, and arterial blood pressure.

PMID- 1028411
TI  - Violence in families: an overview.

PMID- 1028412
TI  - Neurological factors in violent behavior (the dyscontrol syndrome).

PMID- 1028413
TI  - Family violence and criminal behavior.

PMID- 1028414
TI  - Psychodynamic aspects of violence.

PMID- 1028415
TI  - Violence toward children: medicolegal aspects.

PMID- 1028416
TI  - Symposium on violence in families: questions and answers.

PMID- 1028417
TI  - Folie a deux in the parents of psychosocial dwarfs: two cases.

PMID- 1028418
TI  - Juvenile court system. The devil's advocate.

PMID- 1028419
TI  - Pastoral care of the physician.

PMID- 1028420
TI  - Regression as a way of coping with a life-threatening disease.

PMID- 1028421
TI  - Inside the God squad: a panel on the value of staff diversity.

PMID- 1028422
TI  - An oncology self help group.

PMID- 1028423
TI  - The integrity of religious professionals and their style in health care.

PMID- 1028424
TI  - Ministry in the emergency room.

PMID- 1028425
TI  - Ministry to the extended care facility: utilization of seminarian, clergy and
      laity.

PMID- 1028426
TI  - The role of significant others in the pathology and treatment of older adults.

PMID- 1028427
TI  - Assisting student nurses understand and relate to patients with various religious
      and spiritual needs.

PMID- 1028428
TI  - "Continuing education and self-improvement".

PMID- 1028430
TI  - Pastoral performance in peer review: a model for evaluation and education.

PMID- 1028429
TI  - Body talk: teaching non-verbal awareness to staff and students in a general
      hospital.

PMID- 1028432
TI  - Spiritual healing phenomena: implications for pastoral care and counseling.

PMID- 1028433
TI  - Establishing a grief center.

PMID- 1028434
TI  - Local clergy as hospital chaplains--a model for community building.

PMID- 1028435
TI  - "Recruitment, training and use of volunteer clergy for crisis ministry in the
      hospital.".

PMID- 1028436
TI  - "It's not all in their heads".

PMID- 1028437
TI  - The laity: to visit or not to visit.

PMID- 1028438
TI  - The role of the chaplain in the emergency medical system (paramedics) or What's
      missing in T.V.'s "Emergency!".

PMID- 1028439
TI  - A multi-faceted program of pastoral care to terminally ill children.

PMID- 1028440
TI  - Moral and ethical implications of positive and negative euthanasia.

PMID- 1028441
TI  - Religious faith and pastoral care in the crisis of hospitalization.

PMID- 1028442
TI  - [Cytogenetic study of a recent case of trisomy 12p].
AB  - A case of trisomy for the short arm and a part of the long arm of chromosome 12
      is reported. Before the pregnancy sterility was noted during several years. Birth
      weight was normal; the newborn with multiple congenital defects died before the
      4th day. Her mother, grandmother, and two brothers of the latter showed a
      balanced translocation t (5 ; 12) (p15 ; q132). The affected child inherited the
      derived 12 as a 47th chromosome.

PMID- 1028443
TI  - [Cuticular collagen in Lumbricus sp. Ultrastructure of native fibrils and of
      precipitates obtained from acetic solutions].
AB  - The paper describes the techniques used to isolate the cuticular collagen fibrils
      of Lumbricus sp. As revealed by electron microscope examination the isolated
      fibrils, positively and negatively stained, are aperiodic and appear made up of
      bundles of filaments (30 A) with an helicoidal arrangement. A filamentous network
      has been precipitated from the acetic solutions of cuticular collagen. The
      network exhibits an electrondense cross-striation every 3 000 A.

PMID- 1028444
TI  - [States of fragility of chromosome 7 in man].
AB  - The examination of the chromosomes of a seven year old child with severe mental
      retardation, allowed us to bring to light, beside a majority of cells with a
      normal karyotype, a population of about 10% of cells in which chromosome 7 showed
      a gap in the juxtacentromeric area of its short arm. The degree of this
      alteration varied from the simple angulation to the complete break with short
      arm's loss. The functional and structural signification of this abnormality is
      discussed and this case is compared with previous observations concerning the
      abnormalities of this area of chromosome 7 (specially the causal aberrations
      occuring in cell cultures).

PMID- 1028445
TI  - [Study of the arterial vascularisation of the esophagus of micro-angiography].
AB  - Study of the intrinsic vascularization of the oesophagus in eleven organs. A
      technic of microangiography was used. The thoracic portion of the oesophagus was
      carefully studied. The way of penetration of the nutrient arteries and the
      intraparietal vascular pattern were precised. The vascularization is rather poor,
      especially 4-5 cms above the oesophagal hiatus.

PMID- 1028446
TI  - [Histoenzymologic study of the adrenal gland of the dormouse during the annual
      cycle].
AB  - The histoenzymologic study of the adrenals in Glis glis was realized for 4
      enzymatic activities (acid phosphatase, glucose 1 phosphate dehydrogenase, delta5
      3beta-hydroxysteroid dehydrogenase and cholinesterase) completed by the
      simultaneous dosage of glucose-6-phosphate dehydrogenase. The histophotometric
      measures made it possible to differentiate the enzymatic activities of the
      different zones of the adrenal cortex and to show the persistance of an important
      activity of the zona fasciculata and sometimes of the zona reticulata during
      hibernation, independantly of the zona glomerulosa. This study confirms the
      activation of the adrenal cortex during hibernation with a brutal depletion at
      awakening and reduced activity during estivation.

PMID- 1028447
TI  - [Ultrastructural study of the follicular cells of the adenohypophysis of the
      chicken].
AB  - As in other species, a network of follicular cells linked together by functional
      complexes can be observed by electron microscopy in the adenohypophysis of the
      chick. No secretory granules are seen in the follicular cells. They are connected
      with each other by thin and long processes inserted between the glandular cells
      and the perivascular spaces. They limit, by their follicular pole, submicroscopic
      cavities of irregular size and shape. They are empty or occupied by a material of
      variable density. These cells exist very precociously in the embryo but their
      characteristic organisation to form a network is observed only on the 16th day of
      incubation. Our experimental study made it possible to evoke, as a number of
      other authors, that they play a role in the functions of support, exchange,
      transport of secretory material or phagocytosis.

PMID- 1028448
TI  - [Vascularization of the anal canal].
AB  - The arterial blood supply of the anal canal derives from the superior, middle and
      inferior rectal arteries, whose branches reach the anal submucosa. Three main
      arterial trunks in the right anterior, right posterior and left lateral positions
      can be isolated below the pectinate line. They come, for the most important part,
      from the superior rectal artery. On the course of the anal submucosal venous
      plexus are fusiform, saccular or serpiginous dilatations confined to the lower
      half of the anal canal. This plexus is mainly tributary of the superior rectal
      vein to the portal system and secondly, of the middle and inferior rectal veins
      and the lateral sacral veins to the inferior vena cava. Arterio-venous direct
      communications have been demonstrated by serial section and by radiography of
      cadaveric specimens and by selective inferior mesenteric arteriography in
      patients. The erectile property of the anal submucosa as suggested by large
      vascular spaces, arterio-venous shunts and glomic systems may function in the
      erectile mechanism.

PMID- 1028449
TI  - [Changes in the adrenocortical cells of the chick embryo after treatment with
      corticosterone or graft of a functional adrenal].
AB  - The ultrastructural changes of adrenocortical cells of the chick embryo, caused
      by administration of corticosterone or after grafting of an additional adrenal
      gland to the host chorio-allantoic membrane, were studied. The main cytoplasmic
      change is an increased amount of dense bodies and complex bodies. Arylsulphatase
      activity is detected in these bodies which should be included in the lysosome
      series. It is possible that a lysosomal mechanism may be active in the
      adrenocortical cells.

PMID- 1028450
TI  - [The anastomotic system of sub-hepatic veins in man].
AB  - The purpose of this study was to analyze the possibilities of collateral venous
      circulation in the liver of man. 100 specimens taken from autopsy, were injected
      with vinyl-polychloride and corroded. In spite of opinion of some investigators,
      it has been found that the hepatic veins often (possibly always) anastomose
      between each other. The largest are the anastomoses between the right and middle
      hepatic veins. It is evident that there exist good conditions for the venous
      collateral circulation between all the hepatic veins in the human liver.

PMID- 1028451
TI  - [Cytologic study of the peritoneal fluid by puncture of Douglas' pouch].

PMID- 1028452
TI  - [Abortive spermatogenesis in the hybrid duck (cross of male Anas platyrhynchos
      and female Cairina moschata). Ultrastructural study].
AB  - The ultrastructural study of the abortive spermatogenesis of the hybrid drake
      (cross: male Anas platyrhynchos L. X female Cairina moschata L.) shows the
      following characteristics: 1) deep anomalies during the pachytene stage (meiotic
      prophase) where the chromosomes form more or less irregular packs close to the
      nuclear enveloppe; 2) the total lack of 2nd spermatocytes and in their place were
      found: --either some cells with lobed or fragmented nuclei in a cytoplasm filled
      with numerous annulate lamella, lipid droplets and centrioles, --or necrosing
      cells, with vacuolised chromatin close to the inner side of the nucleus and with
      abundant smooth endoplasmic reticulum vesicles and dark mitochondria; 3) numerous
      Sertoli cells overloaded with lysosomes. The mitochondria of the spermatogonia,
      the basal membrane of seminiferous tubules and the Leydig cells have the same
      structure that exists in the fertile Barbary drake testis.

PMID- 1028453
TI  - [Development of atrio-ventricular conduction pathways].
AB  - In the embryonic heart of man and mouse, four rings of specialized myocardium are
      present at the transitions between the different components of the heart tube.
      Further development produces an adult conducting system which is only composed of
      certain parts of these rings. The four ring concept not only explains the normal
      conducting system, but in addition its variations in the hearts of certain
      animals and in malformed human hearts are easily understood.

PMID- 1028454
TI  - The missing link in health services: communicating with the public.

PMID- 1028455
TI  - Training more primary care internists. The Federated Council for Internal
      Medicine: a policy statement.

PMID- 1028456
TI  - ACP's Latin influence.

PMID- 1028457
TI  - A profile of internists: the National Ambulatory Medical Care Survey.

PMID- 1028458
TI  - Viewpoint: the President's page. New specialty boards.

PMID- 1028459
TI  - Internal medicine - will its identity be lost or reinforced?

PMID- 1028460
TI  - Viewpoint: The President's page. Increasing costs of medical care.

PMID- 1028461
TI  - The FDA and the internist.

PMID- 1028462
TI  - ACP self-learning series distribution begins.

PMID- 1028463
TI  - Viewpoint. The President's page. Training position in internal medicine.

PMID- 1028464
TI  - Executive Vice President's rounds. Internal medicine residencies.

PMID- 1028465
TI  - Introducing ACP's MKSAP IV--a prestigious CME program.

PMID- 1028466
TI  - Communicating with the public: a physician's responsibility.

PMID- 1028467
TI  - Investing in the future of internal medicine.

PMID- 1028468
TI  - [Growth and reproduction of the electric ray (Torpedo marmorata) IV. Growth,
      sexual dimorphism, and variation of the interrenal gland, thyroid, and hypophysis
      (author's transl)].

PMID- 1028469
TI  - Definition of surgical microbiologic clean air.

PMID- 1028471
TI  - Effects of withholding elective operations on surgical utilization rates.

PMID- 1028472
TI  - Will the Equal Employment Opportunity Commission control specialty boards?

PMID- 1028473
TI  - The itinerant resident.

PMID- 1028474
TI  - The reports to the Fellows--presented during the Annual Meeting of Fellows,
      October 14, 1976, Chicago. Report from the Chairman of the Board of Regents.

PMID- 1028475
TI  - Three reports to the Fellows--presented during the Annual Meeting of Fellows,
      October 14, 1976, Chicago. Report from the Chairman of the Board of Governors.

PMID- 1028476
TI  - Three reports to the Fellows--presented during the Annual Meeting of Fellows,
      October 14, 1976, Chicago. Report from the Director of the American College of
      Surgeons.

PMID- 1028477
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Colon and Rectal Surgery.

PMID- 1028478
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Neurological Surgery.

PMID- 1028480
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Surgery.

PMID- 1028479
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Plastic Surgery.

PMID- 1028482
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Gynecology and Obstetrics.

PMID- 1028481
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Thoracic Surgery.

PMID- 1028483
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Otolaryngology.

PMID- 1028484
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Orthopaedic Surgery.

PMID- 1028485
TI  - 1976 reports from nine American surgical specialty boards to the Board of Regents
      of the American College of Surgeons. Presented at the meeting of the Board of
      Regents, October 10, 1976, in Chicago, Illinois. Report of the American Board of
      Urology.

PMID- 1028486
TI  - Professional liability--closed claims study.

PMID- 1028487
TI  - Public policy and the paradoxes of plenty.

PMID- 1028488
TI  - The influence of the manpower study of SOSSUS on graduate education in surgery.
      The Symposium on Graduate Education from the 1975 Clinical Congress: residency
      review committee report.

PMID- 1028490
TI  - The influence of the manpower study of SOSSUS on graduate education in surgery.
      The Symposium on Graduate Education from the 1975 Clinical Congress: overview: in
      what direction does all surgery need to go?

PMID- 1028489
TI  - The influence of the manpower study of SOSSUS on graduate education in surgery.
      The Symposium on Graduate Education from the 1975 Clinical Congress: current and
      proposed changes for the foreign medical graduates' entry into the programs (the
      CCME report).

PMID- 1028491
TI  - Surgery--necessary?

PMID- 1028492
TI  - A letter to my sons.

PMID- 1028493
TI  - The foreign medical graduate in American surgery.

PMID- 1028494
TI  - Surgery in Australia.

PMID- 1028495
TI  - The influence of recent changes in graduate medical education on undergraduate
      surgical education: influence of career choices on undergraduate surgical
      education.

PMID- 1028496
TI  - The influence of recent changes in graduate medical education on undergraduate
      surgical education: career selection.

PMID- 1028497
TI  - The influence of recent changes in graduate medical education on undergraduate
      surgical education: effect on recruitment to surgery.

PMID- 1028498
TI  - The influence of recent changes in graduate medical education on undergraduate
      surgical education: effects on recruitment to surgical specialties.

PMID- 1028499
TI  - The federal government and the surgical profession.

PMID- 1028500
TI  - March 1976 Meeting of Young Surgeons. Workshop I. Manpower and allied health
      services.

PMID- 1028501
TI  - March 1976 Meeting of Young Surgeons. Workshop II. Continuing education for young
      surgeons.

PMID- 1028503
TI  - March 1976 Meeting of Young Surgeons. Workshop IV. Professional liability.

PMID- 1028502
TI  - March 1976 Meeting of Young Surgeons. Workshop III. County, state, and specialty
      society disciplinary processes for surgeons.

PMID- 1028504
TI  - March 1976 Meeting of Young Surgeons. Workshop V. Emergency medical services in
      the United States.

PMID- 1028505
TI  - Director's memo. Continuing education.

PMID- 1028506
TI  - Use of items from SESAP No. 1 as a teaching aid in postgraduate medical
      education.

PMID- 1028507
TI  - Optimal hospital resources for care of the seriously injured.

PMID- 1028508
TI  - Primary care--the surgeon's role.

PMID- 1028509
TI  - Misconceptions on surgical residency positions.

PMID- 1028510
TI  - The distribution of load through the knee joint and its possible significance to
      the observed patterns of articular cartilage breakdown.

PMID- 1028511
TI  - An introduction to the biomechanics and biomaterials of bone, joints, and
      implants.
AB  - Biomechanics and biomaterials of bone, joints, and implants has been presented in
      an overview manner with the use of selected examples. The musculoskeletal system
      is a living, dynamic entity that is constructed so that changes in mechanics, if
      the body does not have time to compensate, can lead to major problems over a
      period of time. The mechanics of the tissues ensure a smoothly operating system.

PMID- 1028512
TI  - Differential bone scanning.
AB  - This is a preliminary report of eleven patients with painful total joint
      arthroplasties. In their evaluation the difficulty in the differential diagnosis
      between the loose and the infected total joint becomes apparent. We have found
      the use of differential bone scans an accurate method to identify the infected
      total joint. Further study along these lines is indicated with a larger series
      and generalization to other types of implants.

PMID- 1028513
TI  - Irreduceable metacarpophalangeal dislocations.

PMID- 1028514
TI  - Hemangioma of the extensor pollicis longus: a case history.

PMID- 1028515
TI  - Naviculectomy for congenital vertical talus.

PMID- 1028516
TI  - Cryptogenic infraclavicular brachial plexus neuritis: (preliminary report).

PMID- 1028517
TI  - [Allergic migraine and migraine in the allergic patient].

PMID- 1028518
TI  - [Ocular complications of bacterial septicemia].

PMID- 1028519
TI  - [Case of dacryohemorrhysis].

PMID- 1028520
TI  - [EOG of dyssynergy].

PMID- 1028521
TI  - [EOG of rhythmic saccades].

PMID- 1028522
TI  - [Transcorneal approach to foreign bodies in the irido-corneal angle].

PMID- 1028523
TI  - [Occlusive syndrome of the ophthalmic artery].

PMID- 1028525
TI  - [Classification of 5 strabologic swings].

PMID- 1028524
TI  - [Autofluorescence of papillary drusen in the diagnosis of false papillary edema].

PMID- 1028526
TI  - [A short approach to psychomotor function in the child].

PMID- 1028527
TI  - [A case of regression of diabetic retinitis in a patient affected by carotid
      stenosis].

PMID- 1028528
TI  - [Visual field disorders and hallucinogens].

PMID- 1028529
TI  - [The practice of perimetry].

PMID- 1028530
TI  - [Evolution of the visual field in retinitis pigmentosa].

PMID- 1028531
TI  - [Visual field deficits associated with papillary crossing and dysversions].

PMID- 1028532
TI  - [Visual field and congenital tardive glaucoma].

PMID- 1028533
TI  - [Macular complications in surgery for retinal detachment].

PMID- 1028534
TI  - [Modifications of the visual field in relation to the intrasellar development of
      an intracavernous arterial aneurysm of the internal carotid artery].

PMID- 1028535
TI  - [Deep peri-papillary hemorrhage: visual field and fluorescence angiography].

PMID- 1028536
TI  - [Functional amblyopia and electrophysiologic examination (ERG, AERG, VEP.)
      Preliminary note on 37 cases].

PMID- 1028537
TI  - An evaluation of the effectiveness of parent involvement in a day care program.

PMID- 1028538
TI  - Learning disability as a predisposing cause of criminality.

PMID- 1028539
TI  - The abusive parent: a different perspective.

PMID- 1028540
TI  - Sixty thousand children: the process of establishing a mental health program in a
      school community.

PMID- 1028541
TI  - Project Toddler: "10,000 miles to go".

PMID- 1028542
TI  - Assessing standards in children's mental health: a progress report.

PMID- 1028543
TI  - Role of the Electrical Safety Committee.

PMID- 1028544
TI  - Shared engineering.

PMID- 1028545
TI  - Rehabilitation engineering at Rancho Los Amigos Hospital.

PMID- 1028546
TI  - Hospital technical services and electrical safety.

PMID- 1028547
TI  - Circuits for testing the external demand pacemaker.

PMID- 1028548
TI  - Giant aneurysms of the posterior fossa presenting as space occupying lesions.
AB  - In relation to the case history of a patient, who was observed at the Ursula
      Clinic, Wassenaar, Holland, a survey from the literature is given of 47 cases of
      giant aneurysms of the posterior fossa, which primarily presented as space
      occupying lesions.

PMID- 1028549
TI  - Carotid ligation for carotid aneurysms.
AB  - Thirty patients with subarachnoid haemorrhage due to rupture of a carotid
      aneurysm were treated by ligation of the common carotid artery. Two patients died
      as a result of the procedure, two patients developed persisting hemisphere
      deficit. Eight of the ten patients who developed cerebral ischemia after the
      operation were operated within ten days after the bleeding. At present out aim is
      to guide the patient safely through the first ten days after his haemorrhage and
      perform ligation at the end of the second week. After a follow up period of 1-8
      years recurrent haemorrhage did not occur. Common carotid ligation, preferably
      with control of carotid artery end pressure, cerebral blood-flow and EEG is
      considered to be a valuable method to treat ruptured intracranial carotid
      aneurysm.

PMID- 1028550
TI  - Complications of the chronic subdural hematoma.
AB  - Eighty three chronic subdural hematomas, obtained by surgery or by necropsy, were
      examinated. The patient age distribution curve of the non-complicated operative
      cases showed the highest incidence in the first year of life and also a moderate
      increase in the elderly group. Recurrent hemorrhage in the walls and in the
      cavity, was observed in twenty of the seventy three non-complicated cases of
      chronic subdural hematoma. In five cases the membranes and the subdural sac were
      invaded by leucemic cells and in the five remaining ones the hematoma was
      transformed in a subdural empyema. All these complicated subdural hematomas
      showed evidence of recurrent bleeding, suggesting that the leucemic cells or the
      infectious agent had spread to the subdural space by this way.

PMID- 1028551
TI  - Bilateral acute spontaneous subdural hematoma. A case report.
AB  - A patient is described, with a history of sudden headache and vomiting, without
      major neurological deficit. There was no history of trauma. The cause turned out
      to be an acute spontaneous bilateral subdural hematoma. Comparable cases in
      literature and the etiological possibilities are discussed.

PMID- 1028552
TI  - Cerebral bacterial aneurysms in subacute bacterial endocarditis.
AB  - Bacterial aneurysms are aneurysms which develop on a vascular wall weakened as a
      result of a bacterial infection. They can develop anywhere. This paper describes
      a female patient with subacute bacterial endocarditis and multiple cerebral
      aneurysms. Conservative treatment followed.

PMID- 1028553
TI  - Intracranial tuberculomas.
AB  - In this paper the clinical findings, operation results and histological diagnosis
      of eight patients with intracranial tuberculomas are described, which were
      admitted to the Neurosurgical Clinic of Ankara University, Faculty of Medicine,
      during the years 1967-1975, among the 1,015 histologically verified intracranial
      tumours. Our impression by reviewing previous papers on this matter is, that
      although tuberculomas are not so frequently seen as before, they still count as a
      certain percentage in Turkey.

PMID- 1028554
TI  - Estrogen therapy: the dangerous road to Shangri-La.

PMID- 1028555
TI  - Isofiltration capillary pressure and compartmental vascular resistances following
      elevation of venous pressure in subcutaneous tissue.
AB  - Isofiltration technique was used to measure the functional capillary pressure in
      10 canine hindpaw (mainly subcutaneous tissue) preparations. With simultaneous
      determinations of arterial pressure, blood flow and venous pressure, the changes
      in total, precapillary and postcapillary resistances were assessed at different
      levels of venous pressure. When the tibial arterial pressure was 100 mm Hg. at an
      initial venous pressure of 5 mm Hg, the isofiltration capillary pressure averaged
      12.8 mm Hg, the ratio of pre-to post-capillary resistance 9.9. The precapillary
      resistance accounted for 90.8% of the total vascular resistance. The
      isofiltration capillary pressures were 24.9 and 38.0 mm Hg, respectively when
      venous pressure was elevated to 20 and 35 mm Hg. Capillary pressure (Pc) was
      approximately related to venous pressure (Pv) by: Pc=0.82Pvm8. Upon elevation of
      venous pressure, the total and precapillary resistances were not significantly
      altered. The paw resistance vessels possess neither myogenic nor metabolic
      autoregulation. With increasing venous pressure, presumably due to passive
      distension of venules, the postcapillary resistance fell and the ratio of pre-to
      post-capillary resistance increased.

PMID- 1028556
TI  - A scintiphotographic study of pulmonary edema and hemorrhage induced by cerebral
      compression and norepinephrine.
AB  - Pulmonary edema and hemorrhage (PEH) was induced in rats by cerebral compression
      and intraveneous norepinephrine. We used scintiphotographic method to demonstrate
      the blood volume change in the lung subsequent to the hemodynamic events that
      cause PEH. A specific isotope, Indium-113m, was chosen for this purpose. The
      isotope forms large molecular, complex with plasma transferrin (molecular weight
      of roughly 90,000). It is evenly distributed inside the intravascular space.
      Normally, the lung showed little radioactivity. After cerebral compression or
      intravenous norepinephrine, a marked increase in radioactivity of the lung was
      evident. This indicates an accumulation of blood volume in that area. All the
      animals developed severe PEH which was proved postmortemly. Findings of the
      present as well as the previous studies agree with each other and indicate that
      either cerebral compression or norephinephrine elicits generalized systemic
      vasoconstriction, causing a shift of large amount of blood into the lung. The
      hemodynamic changes finally result in pulmonary hypertension and subsequent PEH.
      The scintiphostographic method may be employed as diagnostic tool when a
      hypervolemic lung change is suspected. Further quantitative analysis is to be
      accomplished for a prospective clinical application.

PMID- 1028557
TI  - [Correlations between the phlebographic and histological findings in experimental
      venous thrombosis].

PMID- 1028558
TI  - [Controlled and dissociated regional perfusion technic].

PMID- 1028559
TI  - [Remote results of surgical treatment of recurrent chronic pancreatitis.
      Considerations on 53 operated patients].

PMID- 1028560
TI  - [Longitudinal myotomy of the sigmoid].

PMID- 1028561
TI  - [Re-infusion of ascitic fluid with high protein content in cirrhosis patients].

PMID- 1028562
TI  - Organ donations by incompetents and the substituted judgment doctrine.

PMID- 1028563
TI  - Liability for failure of birth control methods.

PMID- 1028564
TI  - Rural ambulance service in West Virginia.

PMID- 1028565
TI  - Videotaped guide to staging a basic level EMT practical examination.

PMID- 1028566
TI  - Spinal cord injury: emergency management.

PMID- 1028567
TI  - First forum debate: It is necessary for physicians to teach basic EMT courses.

PMID- 1028568
TI  - Legal barriers to EMS systemization: federal.

PMID- 1028569
TI  - Learning styles of EMT's.

PMID- 1028570
TI  - The EMT as first therapist of the sexual assault victim.

PMID- 1028571
TI  - Monitoring equipment.

PMID- 1028572
TI  - Equipment: Federal Specification, Ambulance KKK-A-1822.

PMID- 1028573
TI  - Paramedics.

PMID- 1028574
TI  - Communication.

PMID- 1028575
TI  - Nursing.

PMID- 1028577
TI  - [Liberation of H3-GABA from isolated nerve endings of the cerebral cortex of rats
      under the effect of psychotropic drugs].
AB  - The influence of a number of neuroleptics and antidepressants on the release of
      3H-GABA from the synaptosomas of the cerebral cortex in rats was studied.
      Chlorpromazine, phthorphenazine, trifluperidol, imipramine, phthoracizine caused
      an intensified liberation of 3H-GABA from the synaptosomas. In this phenothiazine
      neuroleptics proved more active than did trifluperidol and antidepressants. New
      neuroleptics--azabuperon and carbidine and also diphenylhydantoin tended to
      restrict the liberation of the mediator from synaptosomas. The tranquilizer
      diazepam, gamma-oxybutyric acid and carbamazepine failed to have any significnat
      effect on this process. The described effects of thepsychotropic substances are
      due, apparently, to their direct influence on the synaptomal membrane.

PMID- 1028578
TI  - [Characteristics of the development of tolerance to nitrazepam and phenobarbital
      under experimental conditions].
AB  - Despite the similarity of the nitrazepam and phenobarbital spectra it was found
      that with their single usage the nature of tolerance for these substances differs
      quite substantially. With long-term introduction of nitrazepam to mice and rats
      in invariable and increasing doses there is seen a development of tolerance in
      the sense of the muscle relaxant and anticonvulsive action and in lethality
      without any marked attenuation of the tranquillizing effect. In contradistinction
      to this a long-term administration of phenobarbital is followed by a diminution
      of its tranquillizing action and by a slowly proceeding reduction of muscle
      relaxing manifestations. Crosswise tolerance among nitrazepam, diazepam and
      phenobarbital is marked but feebly. It is presumed that one of the possible
      mechanisms responsible for the nitrazepam tolerance in mice and rats may be a
      change in metabolic transformations and redistribution of metabolites.

PMID- 1028579
TI  - [Effects of catecholaminergic substances on the circular reaction caused by
      stimulation of the caudate nucleus].
AB  - The influence of stimulators (L-DOPA and apomorphine) and of inhibitors
      (chlorpromazine and haloperidol) of the dopaminergic systems on the circular
      reaction arising during high-frequency (30 puls/sec) stimulation of the caudate
      nucleus was studied in chronic experiments with freely moving cats carrying 
      preliminarily implanted electrodes. L-DOPA and apomorphine inhibited, while
      chlorpromazine, on the contrary, facilitated the development of a contralateral
      circular reaction. L-DOPA and chlorpromazine modified in a more pronounced
      fashion the circular reaction than did apomorphine and haloperidol. In the
      mechanisms of the circular reaction, apart from the dopaminergic component, the
      participation of noradrenergic systems is suggested.

PMID- 1028580
TI  - [Study of the nature of interactions between narcotic analgesics and barbiturates
      and biological membranes by the method of fluorescent probes].
AB  - By employing the method of fluorescent probes the  interaction of the barbituric
      acid derivatives and phenanthrene with biological membranes was analyzed. An
      association of phenanthrene derivatives with the probe molecules was uncovered.
      As a result of hydrophobic interaction the barbituric acid derivatives dislodge
      the probes from the sites of their bonding with biological membranes. This effect
      correlates with the distribution coefficient of narcotics in the octanol-water
      system.

PMID- 1028581
TI  - [Study of the effect of narcotic analgesics (phenanthrene derivatives)on the
      physico-chemical properties of nucleic acids].
AB  - The effect of narcotic analgetics (phenanthrene derivatives) on the physico
      chemical properties of nucleic acids was studied. It is shown that morphine-like
      substances have no influence on the secondary and tertiary structure of native
      DNA molecules and modified DNA agents.

PMID- 1028582
TI  - [Principles of passage of aminazine through the placental barrier].
AB  - The following regularities governing the transplacental passage of chlorpromazine
      have been established, viz. the drug passes through the placenta only at the end
      of the pregnancy term; with repeated administration to mothers it accumulates in
      the placental and fetal tissues and is contained in the organs of the newborn and
      one-week old animals.

PMID- 1028583
TI  - [Effect of reserpine, octadine and methyldopa on the distribution of cardiac
      output in hypertension].
AB  - Tests conducted on anesthetized rats with experimental renal hypertension
      demonstrated that octadine, reserpine and methyl-DOPA with their one-time
      administration produce at the onset of the maximal hypotensine effect of fall of
      the arterial pressure at the expense of the lowered total peripheral resistance.
      Most characteristic of the action exercised by these drugs is an increased
      fraction of the cardiac ejection going to the gestro-intestinal tract. In
      hypertension all the substances under study reduce the coronary and splenic
      fractions of the cardiac ejection. Reserpine and methyl-DOPA do not change, while
      octadine reduces the fraction of the cardiac ejection that goes to the kidney.

PMID- 1028584
TI  - [Effect of obsidan on the course of experimental myocardial infarct with
      arrhythmias in rabbits].
AB  - Experimental myocardial infarction (EMI) was reproduced in 35 of 40 rabbits
      operated upon. Ampouled obsidan was slowly introduced to 12 rabbits with EMI
      directly after ligation of the coronary arteries and once during each subsequent
      two days into the marginal otic vein. The results of the antiarrhythmic action of
      the drug were judged about from the data of a dynamic ECG-observation in 3
      standard leads. From the information thus obtained it followed that a single
      administration of obsidan to rabbits in the acute period of EMI (the first 3 days
      of the experiment) prevented the development of complex disturbances of the
      rhythm and reduced the lethality rate among the animals. In repeated injections
      of the drug it is necessary to take account of the preceding arrhythmias.
      Reintroduction of obsidan to rabbits with EMI complicated by sinus bradycardia
      and ventricular extrasystole is prognostically dangerous (ventricular
      extrasystole relapses and its transformation into ventricular tachycardia is
      possible). At later stages of EMI these animals succumbod due to complex
      disturbances of the rhythm and conduction.

PMID- 1028585
TI  - [Therapeutic-preventive effect of sodium selenite on the course of experimental
      myocardial infarct].
AB  - An occlusion of the left coronary artery in rats tends to signally raise the
      intensity of free radical oxidation of myocardial-lipids, which is revealed by
      the chemofluorescent method. A direct correlational link between the intensity of
      the lipids peroxidation and the extent of the myocardial damage was established.
      Subcutaneous injection of sodium selenite in a dose of 30 gamma/kg 2 hours prior
      to ligation and once daily for a space of 7 days produces a distincly reduced
      intensity of free-radical processes in the myocardium, decreases the extent of
      infarction and prevents the appearance of gross changes on the ECG.

PMID- 1028586
TI  - [Effect of apressine and euphylline on the bioelectric activity and electrolyte
      balance of the vascular wall].
AB  - In tests staged on cats the effect of apressin and euphylline on the biopotential
      and electrolytes metabolism was studied. Apressin was found to raise the negative
      electricity of the biopotential and the potassium level in the vascular tissue,
      an increase of the dose producing not any further reduction, but rather a higher
      concentration of calcium in the arterial vessels. Euphyliine causes no changes in
      the biopotential, but then raises the potassium content in the vascular wall. An
      accertion of the euphylline dose blocks the egress of calcium from the muscular
      tissue of the arteries. It is  suggested that the relaxing action of the
      introduced substances maycome about owing to stimulation of the processes
      infolving binding of calcium in the smooth muscle cells, while changes in the
      transparietal potential difference are conditioned mainly by counter-gradient
      transport of potassium.

PMID- 1028587
TI  - [Pharmacokinetics of P32-phosphemide in the body of rats with sarcoma 45].
AB  - Pharmacokinetics of phosphamide-32P was studied in experiments on rats with
      sarcoma 45 and intact (tumourless) ones. Soon (15 min to 1 hour) after
      intraperitoneal injection of the compound the maximum amount of the isotope was
      definable in the liver, kidneys, spleen, suprarenals, in the tumour and the
      thymus. The content of the compound in the tumour ammounted to 0.2--0.4 per cent
      of the radioactivity introduced. Distribution of phosphemide-32P among organs and
      tissues of the rats with sarcoma 45 quatitatively differs from that in intact
      animals. During the first 24 hours 55--56 per cent of the radioactivity
      introduced is excreted together with urine.

PMID- 1028588
TI  - [Radioprotective and pharmacological properties of certain phenylethylamine
      derivatives].
AB  - The toxicity of radioprotective and some pharmacological properties of 33
      compounds, phenylethylamine derivatives, substituted in the phenyl ring were
      studied. Some of these display radioprotective and curative properties and also
      produce anesthetizing, coronary dilating, antiarrhythmic and other effects.

PMID- 1028589
TI  - [Determination of embryotoxic and teratogenic effect of a new antidepressive
      agent, pyrazidol].
AB  - The effect of the new original antidepressant pyrasidol on the embryogenesis of
      albino rats was investigated. With a single introduction of the drug with a tube
      into the stomach in a dose of 200 mg/kg within the first 15 days of pregnancy
      pyradisol was found to produce no embrytoxic and teratogenic effects. Fluorescent
      microscopy revealed the presence of the pyrasidol metabolites in the amniotic
      fluid of the test animals 2 hours after enteral administration of the drug, on
      the 15th and 20th days of pregnancy.

PMID- 1028590
TI  - [Effect of 4-amidinophenylpyruvic acid on the generalized Sanarelli-Shwartzman
      phenomenon].
AB  - The influence of 4-amidinophenylpyruvic acid (APPA)--a synthetic thrombin
      inhibitor--on the incidence of disseminated intravascular coagulation was tested
      with the aid of a model of the generalized Sanarelli-Schwarzman phenomenon. After
      application of APPA the thrombogenesis in different organs subsided quite
      significantly.

PMID- 1028591
TI  - [Effect of different doses of strychnine on blood coagulation and lymph].
AB  - Tests conducted with dogs ascertained that strychnine used in a dose producing
      convulsions brings on an intensified coagulation of the blood and lymph along
      with a higher fibrinolytic activity. This reaction is largely due to the ejection
      of thromboplastic and fibrinolytic agents from the active muscles.

PMID- 1028592
TI  - [Distribution of beryllium in the organs of rats].
AB  - Tests with albino female-rats evidenced that following intravenous,
      intraperitoneal and intramuscular administration of Be to critical organs the
      ones most likely to be implicated proved the liver, kidneys and the skeleton,
      while with intratracheal introduction it were the lungs.

PMID- 1028593
TI  - [Toxic effect of phosphamide after simultaneous entrance into the body through
      the gastrointestinal tract and respiratory organs].
AB  - The experiment involved an investigation into the action of O,O-dimethyl-S-(N
      methyl-carbomoilmethyl)-dithiophosphate (phosphamide), used at the level of the
      liminal dose (4 mg/kg) and in a concentration of 1.9 mg/m3, as compared with the
      effect of 1/2 of the liminal dose and 1/2 of the thereshold concentration. Both
      were simultaneously introduced into the organism of test albino rats for a period
      of 4 months and their complex action showed an intensification of the toxic
      effect. In evidence was also a more marked anticholinesterase action, a higher
      level of the insecticide in biological substrates and greater changes of
      hematological indices.

PMID- 1028594
TI  - [Morphological substantiation of treatment of liver cirrhosis with retabolil].
AB  - The effect of retabolil on experimental liver cirrhosis in rats was studied. The
      results of the treatment point to a beneficial action of retabolil on the course
      of this malady, which found its expression in the prevalence regeneration
      manifestations over the processes of degeneration, as well as in the inhibitory
      effect on the development of liver cirrhosis. From morphometric investigations it
      follows that for retabolil the structure-target is the nucleonic system of the
      cells, largely of hepatocytes.

PMID- 1028595
TI  - [Toxicological study of an antiviral drug, bonaphthon].
AB  - The toxicity of bonaphthon was studied on laboratory animals of different species
      (mice, rats, guinea pigs, dogs) with its single and repeated (daily, for a space
      of 4 months) administration. It has been found that bonaphthon, with its single
      and repeated administration in doses much higher (by 16 to 32 times) than the 
      ones recommended for human beings, is well tolerated not only by sexually mature,
      but also by immature animals (rats). Bonaphthon does not affect adversely the
      dynamic changes in the weight of the animals, nor does it have any effect on the
      diuresis, functional state of the gastro-intestinal tract and the cardiac
      activity. On its administration in toxic doses exceeding by 60 and more timesthe
      ones recommened for human beings the drug provokes flabbiness, bradycardia, a
      fall of arterial pressure and causes changes in the activity of nonspecific
      enzymatic systems of the liver. Among the test animals most sensitive to
      bonaphthon are mice.

PMID- 1028596
TI  - [Experimental study of the anabolic activity of 6-ketoderivatives of certain
      natural sapogenins].
AB  - It is shown that 6-ketoderivatives of natural sapogenins, viz. agigenin,
      diosgenin and alliogenin, display the anabolic activity and do not manifest any
      androgenic properties. The compoud IV/(25 R)-5alpha-spirostan-2alpha, 3beta,
      5alpha-triol-6-OH/produces an accelerated gain of weight in rats, and also an
      increase in the weight of the liver, heart, kidneys, musculus tibiliasis anterior
      and augments the total amount of protein therein. All of the above-mentioned
      changes become more pronounced with the study substance introduced to young
      animals. Castration of sexually immature rats greatly mitigates the anabolic
      effect of the compound IV.

PMID- 1028597
TI  - [Comparative evaluation of the methods of determination of the orientation
      reaction of rats in a toxicological experiment].
AB  - A procedure for determining orientation reaction after Boissie et al (1964) was
      modified for albino rats. In determining the thresholds of acute action of
      phthalates and carboran in comparison with summation-threshold index,
      registration of spontaneous motor activity and orientation reaction according to
      the number of risings in a jar the proposed method is shown to be 5-10 times more
      sensitive.

PMID- 1028598
TI  - [Study of toxicity of nosepam under experimental conditions].

PMID- 1028599
TI  - State organizations for human services.

PMID- 1028600
TI  - Inside DOPE The custom research databank in the analysis and transfer of
      information.

PMID- 1028601
TI  - The Mega-Proposal.

PMID- 1028602
TI  - Is services integration dangerous to your mental health?

PMID- 1028603
TI  - A system approach to human services integration.

PMID- 1028604
TI  - Two views on services integration: Bertram S. Brown and Reubin Askew, by Susan
      Salasin.

PMID- 1028606
TI  - Rural community mental health center uses decision-making model.

PMID- 1028605
TI  - Two views on services integration: Bertram S. Brown and Reubin Askew, by Susan
      Salasin.

PMID- 1028607
TI  - Women's utilization of mental health services studied.

PMID- 1028608
TI  - Income patterns tied to mental health treatment.

PMID- 1028610
TI  - Evaluating children's mental health services.

PMID- 1028611
TI  - Anti-suicide program conducts controlled study.

PMID- 1028612
TI  - The mental health consultant role in program research.

PMID- 1028613
TI  - Establishing a model data system.

PMID- 1028614
TI  - Goal consistency: a prerequisite to evaluation of halfway houses.

PMID- 1028616
TI  - Services integration and the Department of Health, Education, and Welfare.

PMID- 1028615
TI  - Training evaluators at the masters level: an experimental program.

PMID- 1028617
TI  - HEW capacity-building (federal, state, and local)--policy statement issued march
      20, 1975--.

PMID- 1028618
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028619
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028620
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028621
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028622
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028623
TI  - Organizing human services in Florida. Response to a public policy process.

PMID- 1028624
TI  - "Deinstitutionalization," a public policy fashion.

PMID- 1028625
TI  - Organizing human services in Florida. Teaching public policy.

PMID- 1028626
TI  - Student views of human services delivery in Florida.

PMID- 1028627
TI  - Student views of human services delivery to Florida.

PMID- 1028628
TI  - Evaluation in a Community Mental Health Center: Hillsborough CMHC, Tampa,
      Florida.

PMID- 1028629
TI  - Developing optimum drug regimens.
AB  - In clinical pharmacological trials the determination of the optimum regimen for a
      drug using the technique of response surface analysis is proposed as being more
      advantageous than traditional analyses of dose response relationships. Major
      considerations in favour of this technique are that the optimum regimem can be
      identified with a minimum of human experimentation, and unacceptable regimens are
      eliminated from the study early, at a substantial saving of time and money.

PMID- 1028630
TI  - Three years of bacteriological monitoring in the Department of Paediatric
      Surgery.
AB  - The results of three years of bacteriological monitoring in the Department of
      Paediatric Surgery at the Ospedale Maggiore Ca'Granda in Milan are reported. The
      tests carried out involved the patients (faeces, urine, and pus cultures), the
      environment (operating theatre, incubators), and healthy carriers (upper
      respiratory tract of nursing and paramedical staff). The aetiopathogenesis of the
      post-operative infectious complications that occurred in 1974-1975 was
      investigated with the aid of surveys of the causative pathogens, the type of the
      surgical interventions, the atmospheric pollution in the operating theatre (mean
      indicative values), the number of operations per month, and the frequency of
      positive findings among the carriers. As a parallel investigation, between 1971
      and the time of writing of this report the authors monitored the resistance to
      gentamicin of bacteria belonging to the family Pseudomonadaceae isolated from
      patients, in view of the constant threat posed by the vicinity of the burns
      department.

PMID- 1028631
TI  - Polyacrylic bone cement containing erythromycin and colistin. I. In vitro
      bacteriological activity and diffusion properties of erythromycin, colistin and
      erythromycin/colistin comibination.
AB  - Erythromycin and colistin demonstrate a non-antagonistic ability to inhibit the
      growth of a wide variety of aerobic and anaerobic bacterial isolates. When
      incorporated in Surgical Simplex P Radiopaque Bone Cement, fabricated cement
      pellets were effective in inhibiting 98% of all anaerobic and aerobic test
      isolates. Separate experiments indicate that each antibiotic can diffuse from
      polymerized cement, and that the concentration of each antibiotic is consistently
      above the minimum inhibitory concentration of 96% of the isolates. We conclude
      that erythromycin/colistin Surgical Simplex P radiopaque Bone Cement is a worthy
      candidate for clinical investigation.

PMID- 1028632
TI  - Short-term and long-term clinical evaluation of a non-amphetaminic anorexiant
      (mazindol) in the treatment of obesity.
AB  - The effectiveness and tolerance of a non-amphetaminic anorexiant drug has been
      evaluated in a short-term and in a long-term clinical trial in simple obesity and
      in refractory obesity. In the short-term 'crossover' trial, a more evident
      effectiveness and tolerance result when the anorexiant is given in a late phase
      of treatment. The association of an anorexiant drug with the hypocaloric diet was
      seen to be effective in the treatment of so-called refractory obesity. In the
      evaluation of the long-term treatment it is seen that weight loss is greater and
      remains so farr longer periods in patients receiving anorexiant, as compared to
      controls. This is related to a better maintenance of a restricted calorie
      regimen. Mazindol did not affect the improvement of glucose tolerance and insulin
      secretion which follows the weight reduction.

PMID- 1028633
TI  - An evaluation of a once daily dosage regime of dothiepin hydrochloride
      (prothiaden).
AB  - This paper reports on the use of a single daily dose of dothiepin hydrochloride
      (Prothiaden). The results from a metabolism study using [14C] dothiepin were used
      to calculate the daily variations in blood levels after once daily and thrice
      daily dose regimes. A clinical study on the use of a single daily dose of 75 mg
      of dothiepin showed this type of regime to be well tolerated and efficacious in
      the treatment of 105 depressed patients in general practice. Compared to a thrice
      daily regime the once daily dose appeared to be more beneficial on symptomatic
      insomnia during the early treatment period.

PMID- 1028634
TI  - Effects of cloprednol and other corticosteroids on hypothalamic-pituitary-adrenal
      axis function.
AB  - The effects of cloprednol and other corticosteroids on hypothalamic-pituitary
      adrenal (HPA) function were studied in healthy subjects after administration of a
      single oral dose of corticosteroid at 6 a.m. or 6 p.m., and after daily 6 a.m.
      administration of corticosteroids at various doses for seven days. The degree of
      HPA suppression was assessed by metyrapone tests (METP), insulin hypoglycaemia
      tests (IHT) and 6 a.m. fasting plasma cortisol concentrations. Regardless of the
      corticosteroid tested, 6 p.m. dosing was at least four-fold more suppressive of
      METP response than 6 a.m. administration. At therapeutically equivalent doses,
      single doses of triamcinolone and dexamethasone were more suppressive of HPA-axis
      function than cloprednol, hydrocortisone or prednisolone, After 6 a.m.
      administration for seven days, 12-5 mg of cloprednol did not impair the cortisol
      response to IHT or interfere with the METP response. The clinically equivalent
      dose of prednisolone (25 mg) resulted in slightly greater HPA-axis suppression.
      All doses of dexamethasone (0-5, 3-75 and 6-0 mg) and of betamethasome (2-0, 4-0
      and 6-5 mg) were more suppressive of HPA-axis function than either cloprednol or
      prednisolone. These results suggest that at equipotent anti-inflammatory doses,
      cloprednol is slightly less suppressive of HPA-axis function than prednisolone,
      and both cloprednol and prednisolone are much less suppressive than dexamethasone
      or betamethasone.

PMID- 1028635
TI  - A study of once daily tenormin (atenolol) in hypertension: some implications in
      patient compliance.
AB  - A clinical study is described in which hypertensive patients on no drug therapy
      were given atenolol in increasing doses from 50 mg twice daily to 200 mg twice
      daily until the diastolic blood pressure was 90 mm Hg or below. At this stage the
      drug was withdrawn until blood pressure readings had risen to pre-treatment
      levels. The same dose of atenolol was then re-introduced but now given once-a-day
      (in the morning) and was continued for four weeks. Of the elevel patients
      entering the study, one withdrew as his blood pressure was not controlled on a
      dose of 200 mg of atenolol twice daily, and another because on withdrawal of
      atenolol his blood pressure did not rise to pre-treatment levels. The remaining
      nine patients completed the study. There was a statistically significant fall in
      blood pressure on both atenolol regimes and there was no significant difference
      between the blood pressure control achieved on twice-a-day and once-a-day
      administration. Only one patient developed side-effects; this being an asthmatic
      who developed mild dyspnoea on atenolol which did not necessitate withdrawal of
      the drug. It is concluded that once-a-day administration of a given dose of
      atenolol is therapeutically equivalent to twice-a-day administration. The
      implications of this in terms of better patient compliance, and thus better
      prognosis, are discussed.

PMID- 1028636
TI  - Bioavailability of digoxin and beta-methyl-digoxin.
AB  - In a randomized crossover study the bioavailability of a single dose of digoxin
      and of beta-methyl-digoxin tablets was tested in four normal volunteers. No
      difference was found between the two products in the rate and extent of drug
      absorption using 6 day cumulative urinary excretion and serial serum
      concentration measurements.

PMID- 1028637
TI  - Sulphonylurea and hypothyroidism in Nigerian diabetic subjects.
AB  - Thyroid function has been assessed using the T3-Uptake test in 98 nigerian
      diabetic and 50 non-diabetic control subjects. Whilst abnormal tests suggestive
      of thyroidal hypofunctional state were commoner in the group on chlorpropamide
      alone, and in combination with metformin, these were unrelated to the duration of
      treatment. In addition, none had clinical hypothyroidism.

PMID- 1028638
TI  - Physiopathologic relevance of alternative pathway of complement activation.

PMID- 1028639
TI  - Prostaglandins as modulators of the inflammatory response in the rat.
AB  - E-type PGs, injected in rat skin at a low dose concentration (1-5 ng ml-) proved
      not to release vasoactive amines from local mast cell, enhance increase in
      vascular permeability evoked by hypersensitivity endogenous inflammatory
      reactions (passive cutaneous anaphylaxis and reversed passive Arthus) or by
      intradermal injection of histamine and bradykinin. The possible role of PGE1 and
      PGE2 as modulators of the inflammatory response is discussed.

PMID- 1028640
TI  - The effect of pre-treatment of syngeneic mice with tumour cells cultured in vitro
      on the induction of a transplantable tumour.
AB  - The pre-treatment with in vitro cultured mammary adenocarcinoma (ADK-1t) cells
      strongly protects syngeneic Balb/c mice against the challenge with the same non
      cultured tumour cells. If the cultured cells were detached with sodium versenate,
      50-60% protection was given, whereas if trypsin was used only 20-30% protection
      was achieved. That in vitro culture considerably reduces the oncogenic potential
      of ADK-1t cells was shown by the fact that very many more cultured than non
      cultured cells were required to induce tumours.

PMID- 1028641
TI  - [A new type of Salmonella: S. maregrosso, =66:z35:-, subgenus I, atypical].

PMID- 1028642
TI  - [Absorption of radiocobalt in Chlorella vulgaris]?1Assorbimento di radiocobalto
      in "Chlorella vulgaris".
AB  - The uptake, accumulation and loss of traces of radiocobalt present in the culture
      medium by a green alga, Chlorella vulgaris, were studied. The trace quantities of
      the radionuclide employed had no effect on the growth of the algal population.
      The uptake is related to the number of cells present and to the temperature of
      the culture medium; it is not affected by mitotic activity. The rate of the 60Co,
      uptake during algal growth is compared to the rate of uptake of other
      radioisotopes; 90Sr and, to some extent, 137Cs have the same rate of uptake as
      60Co, whereas 90Y and 144Ce differ. Perhaps the radiocobalt in the cells
      undergoes a chelating process and consequently its loss to the outer environment
      is very slow. The involvement of a biological process, in addition to a physical
      one, is claimed in order to explain the possibility of an active concentration of
      the radioisotope (C.F.=170). Emphasis is laid on the possible danger of this
      concentration when a disposal system by dilution of industrial or nuclear waste
      is employed.

PMID- 1028643
TI  - [Serotyping of Salmonella isolated in the Piedmont region in the years 1975
      1976].
AB  - Ninehundredtwentysix bacteria of genus Salmonella, collected from hospitals,
      provincial laboratories and university centers of Piedmont (Italy) have been
      serologically tested. The serotypical frequencies were compared with those
      reported in literature. Our findings shown that the appearance of new and unusual
      serotypes is dominant in comparison to traditional ones.

PMID- 1028644
TI  - [Possible contamination of preparation of transfer factor with bacterial
      endotoxins].
AB  - In order to detect the possible contamination with bacterial endotoxins of some
      preparations of Transfer Factor, Limulus amebocyte lysate test was performed. The
      results obtained (TF preparations positive with L.T. for endotoxin assay) call
      sur detection to evaluate very carefully the immunologic responses in vitro ad in
      vivo, with these biological products contaminate can induce. In fact, bacterial
      endotoxins with their multiple potent effect on biologic system, represent a
      contant possible surce of variability in experimental biology and pathology.

PMID- 1028645
TI  - Inhibition of ADP-induced platelet aggregation as a possible test for evaluation
      of the enterotoxigenicity of some enterobacteria. Preliminary study.
AB  - Some culture filtrates or enterotoxin preparations from enterobacteria that
      activate the adenylate cyclase system (vibrio cholerae, LT fraction from
      escherichia coli and klebsiella pneumoniae, shigella dysenteriae type 1) exibit
      an inhibiting effect on ADP-induced platelet aggregation, while other enterotoxin
      preparations not effective on adenylate cyclase system, don't interfere with this
      model. The A. propose the platelet aggregation as cellular assay to detect
      enterotoxin fractions effective upon adenylate cyclase system.

PMID- 1028646
TI  - [Behavior of natural immunity factors in systemic mycoses. I. Determination of
      lysozyme by means of a new technic].
AB  - Serum lysozyme of 138 patients with various systemic mycosis was determine by
      means of a new technique. It is reported that the levels of the enzyme are very
      low, particularly in the most serious diseases. The significance of this finding
      is discussed.

PMID- 1028647
TI  - [Endotoxemia and phagocytic function in premature subjects].
AB  - The AA. have evaluated some parameters of leukocyte function (phagocytosis,
      killing and nitroblu tetrazolium NBT test) from premature children, comparing
      such activities with endotoxemia, detected by means of limulus assay. The results
      obtained point out that there is not relationship between impaired leukocyte
      functions and endotoxemia.

PMID- 1028648
TI  - [Verification of contamination with bacterial endotoxins in blood derivatives
      used in coagulative disorders: observations with the Limulus test].
AB  - The AA. expose the results of an investigation for an in vitro endotoxin assay by
      Limulus lysate test in blood products employed in coagulative area. The Limulus
      assay has been shown to be a simple, rapid, accurate and sensitive method of
      detecting bacterial endotoxin or endotoxin-like material in these biological
      products.

PMID- 1028649
TI  - [In-vitro microbiological evaluation of the action of gentamicin and sisomicin o
      schizomycetes of the Salmonella genus].
AB  - The in vitro activity of Gentamicin and Sisomicin towards 142 clinical isolated
      Salmonella strains was determined and statisically evaluated. The majority of the
      Salmonella strains was inhibited by concentrations of both antibiotics ranging
      between 0.75 mcg/ml and 0.02 mcg/ml in the Minimal Inhibitory Concentration (MIC)
      test and between 1.5 mcg/ml and 0.02 mcg/ml in the Minimal Bactericidal
      Concentration (MCB) test.

PMID- 1028650
TI  - [The in-vitro action of amoxicillin on 87 strains of Staphylococcus aureus of 1st
      isolation].
AB  - In vitro activity of Amoxycillin towards 87 strains of Staphilococcus aureus
      clinically isolated was analyzed. The 70% of the strains were very sensitive to
      the antibiotic action. Moreover the growth of the 50% of the strains was
      inhibited by Amoxycillin concentrations less than 0.20 mcg/ml.

PMID- 1028651
TI  - [Presence of Salmonella Wien in Gela in 1976].
AB  - The spreading of Salmonella Wien at Gela is proved by its isolation from the
      faeces of twelve patients hospitalized in the isolation department of Vittorio
      Emanuele II Hospital at Gela (Italy) from May to October in 1976. The isolated
      Salmonella shows the same serological characteristics and the same features of
      resistance to the antibiotics of the stocks responsable for the epidemics in
      Algeria and in France.

PMID- 1028652
TI  - [Jennerian vaccination in Siena at the beginning of the 19th century].

PMID- 1028653
TI  - [Ramsay-Hunt dyssynergia cerebellaris myoclonica: presentation of a familial
      strain].

PMID- 1028654
TI  - [Metastasis of testicular seminoma 16 years after orchiectomy].

PMID- 1028655
TI  - [Anti-inflammatory drugs and platelet anti-aggregation activity: difenpiramide].

PMID- 1028656
TI  - How patient educators view their role...and yours.

PMID- 1028657
TI  - Executive session [or: how our board avoids boredom].

PMID- 1028658
TI  - How hospital relationships shape the growth and stability of groups.

PMID- 1028659
TI  - The health manpower act.

PMID- 1028660
TI  - Education directors: moving into a class by themselves.

PMID- 1028661
TI  - [Studies of the discus articularis ulnae by use of arthrography of the wrist
      joint].
AB  - Lesions of the "discus articularis ulnae" (triangular fibrocartilage) are
      presented. Possible differences between the left and the right hand, as well as
      possible age and sex-linked differences were statistically analysed. In 22 wrist
      the disc was removed. The anatomical and pathological findings correlated with
      the arthrogram in all cases. Due probably to the advanced age of our study
      material disc lesions were found to be more frequent than in previous studies.
      The lesion was less frequent in men than in women. No difference could be shown
      between the left and the right hand. The arthrographic variations of the joint
      spaces adjoining the wrist were found to be symmetrically distributed. In no case
      could a communication between the wrist and the distal radioulnar joint be shown.

PMID- 1028662
TI  - [A new ceiling microscope suspension for plastic and reconstructive
      microsurgery].
AB  - Since 1969, 168 microsurgical interfascicular nerve transplantations have been
      performed in the Department for Hand Surgery and Plastic Surgery in the Surgical
      Clinic of the University of Erlangen. Since the end of 1974, the Zeiss Operation
      Microscope OPMI 2 has been hung from an electrohydraulic ceiling suspension and
      has proved invaluable. The construction and function of the apparatus is
      described. Such suspension of the microscope in combination with original Hanau
      operation lights, facilitates microsurgery in hand and plastic surgical procedure
      by saving space, reducing operating time and providing a better opportunity of
      ensuring sterility in the operating field.

PMID- 1028663
TI  - [Reconstruction of thumb length by "on-top plasty"].
AB  - We report the case of a 23 year old man who suffered amputation of thumb and
      index finger at the metacarpophalangeal joint by an injury with electrical
      current. In order to elongate the first ray an on-top plasty of the second on the
      first metacarpal bone was performed. The second metacarpal was severed above the
      base and with the intact vessels and the first dorsal interosseous muscle placed
      on the distal end of the first metacarpal. The second dorsal interosseous muscle
      was severed. The first and second  metacarpal bones united with an intramedullary
      cortical inlay graft. Nerve and vessels as well as the skin of the back of the
      hand could be moved without tension. An abdominal tube was applied to the palm
      because of severe scarring. As a final result pinch grip between the thumb ray
      and the rest fingers is possible. The other fingers are freely movable.

PMID- 1028664
TI  - [Injuries of the terminal phalanx and nail].
AB  - In children the treatment of pulp injuries should amed at conservation. In
      amputations, replantation should always be tried owing to the high possibility of
      success and subsequent of functional recovery. In non-specialized workers the
      simplest and shortest operative procedure (natural healing or skin graft) should
      be preferred to ensure the quickest possible return to work. In specialized
      manual workers such as musicians and typists, the return of the sense of touch
      along with a functional distal joint is essential. In these cases all necessary
      reconstructive procedures are indicated. In women the cosmetic appearance is most
      important and requires precise nail reconstruction. Special considerations apply
      to certain digits: 1. The thumb should be kept as long as possible, without bone
      sacrifice, requiring plastic procedures to ensure good skin cover. When possible
      these should employ local flaps which may restore sensation, especially
      significant on the ulnar side of the pulp. If these local flaps are not possible,
      sensitive flaps (KUHN/HOLEVICH type) or sensory island flaps (MOBERG, LITTLER or
      HILGENFELDT type) may be used. 2. In the little finger conversation is almost as
      important as this digit is mobile, autonomous and represents the usual contact of
      the ulnar side of the hand. 3. In the index finger, employed manity for fine
      actions, DIP mobility is important for good pick up ability. Local flaps are
      preferred. If impossible sensitive flaps should be used on the radical aspect of
      the pulp, to avoid functional substitution of the middle finger for the index.

PMID- 1028665
TI  - [Effect of operations in  a bloodless field on the fine structure of the hand
      muscles].
AB  - For young and healthy patients undergoing reconstructive operations following
      tendon or nerve lesions histological examination of the intrinsic muscle was
      performed. The authors have not found any morphological alterations following the
      use of a tourniquet up to two hours even if the muscles have been damaged by the
      injury.

PMID- 1028666
TI  - Disseminated intravascular coagulation.

PMID- 1028667
TI  - Effect of potato protease inhibitor on the clotting system and fibrinolysis in
      the dog.
AB  - The potato inhibitor of proteolytic enzymes was found to inhibit the plasma
      clotting and fibrinolytic systems in the dog. The anticoagulative action of
      potato inhibitor consists in a prolongation of clotting time, inhibition of
      thromboplastin generation, reduction of prothrombin consumption and of the
      retractility of the blood clot. The potato inhibitor prolongs the euglobulin
      fibrinolysis time and causes a rise in the plasma antiplasmin level.

PMID- 1028668
TI  - Postsplenectomy thrombocytosis in the mouse: changes in the size of thrombocytes.

PMID- 1028669
TI  - Comparative studies on platelet membrane preparations.
AB  - For the isolation of platelet plasma and cytoplasmatic membranes, the following
      methods were applied. 1. Glycerol-osmotic lysis technique, combined with
      sonication. 2. Glycerol-osmotic lysis technique carried out on fresh or frozen
      platelets. 3. Detergent treatment followed by separation of the protein fractions
      insoluble at low ionic strength. The detergents used were Triton X-100, Nonidet P
      40, Na-deoxycholate and digitonin. The protein fractions were compared by SDS-PAG
      electrophoresis.

PMID- 1028670
TI  - Lanthanum Trichloride induced blood coagulation defect and liver injury.
AB  - The rare earth metals have anticoagulant and hepatotoxic effects, among others.
      In view of the connection between liver and blood coagulation, the character of
      the coagulation defect developing in rabbits treated with lanthanum trichloride
      (La) was studied and in connection with it, the role of the liver injury
      described earlier. The results showed the effect to depend primarily on the dose
      of the drug administered; acute and prolonged treatments produce coagulation
      defects different in type. The effect of a single large dose is characterized by
      a severe disturbance of thrombin formation: Prothrombin activity is decreased,
      PTT is prolonged, native blood does not coagulate but may be coagulated with
      thrombin, and its fibrinogen content is high. The effect cannot be regarded as a
      result of the liver injury. On giving La in repeated smaller doses, a disturbance
      of intrinsic thromboplastin (or thrombin) formation develops, as indicated by a
      decrease in prothrombin consumption. This might be due to an alteration of some
      serum factor or of the thrombocyte lipid factor (factor 3) and is probably
      connected with the liver injury.

PMID- 1028671
TI  - The effect of colloidal gold on blood coagulation.
AB  - Coagulation tests were carried out in rabbits after the intravenous
      administration of 2 mg/kg colloidal gold. Among the clotting factors, platelet
      Factor 3 and Factor XIII were found to be inhibited by the gold preparation. Gold
      at 2 mg/ml concentration induced an overall antithrombotic state in spite of an
      increased tendency to platelet aggregation. These experiments suggest a new
      possibility for the inhibition of Factor XIII and platelet Factor 3.

PMID- 1028672
TI  - Haptoglobin level in haemophiliacs after administration of pooled cold
      precipitated antihaemophilic globulin. Preliminary report.
AB  - Unlike compatible haemophiliacs, incompatible haemophiliacs developed a decrease
      in haptoglobin level after administration of pooled cryoprecipitate. The effect
      is attributed to haemolysis following intravascular agglutination and
      intravascular coagulation elicited by the cryoprecipitate in incompatible
      patients.

PMID- 1028673
TI  - Polyagglutinability associated with the cad antigen.
AB  - Various anti-Cad and anti-Sda reagents were tested against a panel of Cad red
      cells in order to determine whether Cad and Sda antigens were identical.
      According to the results, although strong Sda reactivity was always found in Cad
      red cells, the two antigen specificities are not identical. The
      polyagglutinability of Cad red cells seems to be related to an anti-Cad present
      in all human sera but Cad, and not with anti-Sda antibody.

PMID- 1028674
TI  - Jk(a-b-) phenotype in a French family. Quantitative evidence for the inheritance
      of a silent allele (Jk).
AB  - A Caucasian French family was investigated including two Jk(a-b-) sibs who had
      developed anti-JkaJkb. The parents were first cousins. Quantitative study of Kidd
      antigens using titration scoring and HD50 assay clearly showed the parents and a
      maternal aunt, phenotypically Jk(a+b-), to have a weak expression of Jka
      documenting thereby the transmission of the postulated silent gene Jk.
      Absorption, elution and coagglutination assays revealed the cross reactivity of
      the antibody developed by the two sibs. Leucocytes and platelets from these two
      individuals were not shown to absorb anti-JkaJkb.

PMID- 1028675
TI  - Kinetics of mononuclear phagocytes after thymectomy.
AB  - Some kinetic parameters of mononuclear phagocytes have been studied. Wistar rats
      were injected with 3H-thymidine. Samples of peripheral blood and peritoneal
      macrophages were obtained at 12, 14, 24, 36, 48, 60, and 84 hours respectively
      after injection. The labelling index and the mean grain count were determined.
      The turnover of monocytes was slowed down in the thymectomized animals. It is
      assumed that thymectomy had changed some biological qualities of mononuclear
      phagocytes and/or the humoral relations connected with the function and the
      regulation of mononuclear phagocytes.

PMID- 1028676
TI  - Acute effect of endogenous inhibitors and exogenous cytostatics on the
      ultrastructure of bone marrow cells. I. Single dose of 1,2 : 5,6
      dianhydrogalactitol (DAD).
AB  - The ultrastructural effects of the endogenous inhibitor, granuloid crude extract
      (GCE), known to control the proliferation of myeloid cells, and of the current
      hexitol derivative, 1,2 : 5,6-dianhydrogalactitol (DAD) were compared on the rat
      bone marrow. A single intraperitoneally injected LD50 dose of DAD induces the
      following changes in the fine structure: The mitochondria become swollen, the
      matrix less electron-dense, the cristae fragmentate, the ribosomes aggregate,
      anomalies appear in the perinuclear the cell membranes, and myelin figures and
      intranuclear bodies develop. Autophagy,  degeneration and the phagocytotic
      activity of the reticulum cells is appreciable in 4 hours after treatment and
      increase by the 24th hour. The toxic effect of DAD is cell aspecific but in the
      ultrastructure its myelotropic effect manifests earlier than in erythropoiesis.
      In contrast, the arrest caused by a single dose of the endogenous granuloid
      inhibitor [2] is cell-specific and non-toxic.

PMID- 1028677
TI  - Acute effect of endogenous inhibitors and exogenous cytostatics on the
      ultrastructure of bone marrow cells. II. Single dose of granulocyte crude extract
      (GCE).
AB  - The particle-free crude extract of granulocytes (GCE) contains at least three
      inhibitors of proliferation (M.w. greater than or equal to 70,000, approximately
      11,500 and less than or equal to 4000, [5,5]). Intraperitoneal administration of
      a single effective mitodepressive dose (EDM = 59.4 mg/kg b.w. protein) does not
      damage the majority of rat bone marrow cells. The observed slight ultrastructural
      alterations are as follows. The cristate pattern of the mitochondria is
      occasionally deficient, their matrix may contain membrane shreds or myelin
      figures, the package of individual granules may be injured. Cytoplasmic
      vacuolization, autophagy are infrequent and nuclear bleb formation occurred in a
      single case only. The incidence of such injuries is practically the same in
      untreated bone marrow cells. Although GCE effectively inhibits cell
      proliferation, its single dose does not induce such toxic, irreversible and
      degenerative ultrastructural alterations as have been observed in the same system
      after the administration of the cytostatic dianhydrogalactitol.

PMID- 1028678
TI  - The Tarasoff decisions: suing psychotherapists to safeguard society.

PMID- 1028680
TI  - Let's get started on improvement.

PMID- 1028679
TI  - Future drugs that will be lifesavers for the industry too.

PMID- 1028681
TI  - Perfect accountability.

PMID- 1028682
TI  - Satisfaction guaranteed.

PMID- 1028683
TI  - Motivation: key to good results.

PMID- 1028684
TI  - Spotlight on the staff. Housekeeping.

PMID- 1028686
TI  - Make instructions mistake-proof.

PMID- 1028685
TI  - When the problem is productivity.

PMID- 1028687
TI  - A case study of performance improvement, part 1: The program.

PMID- 1028688
TI  - Spotlight on the staff. Physical therapy.

PMID- 1028689
TI  - Management of nursing care. A problem-solving approach to discipline.

PMID- 1028690
TI  - More mileage from days off.

PMID- 1028691
TI  - Healthcare at home.

PMID- 1028693
TI  - Contracting for mental health.

PMID- 1028692
TI  - A case study of performance improvement, part 2: the payoffs.

PMID- 1028694
TI  - Management of nursing care: build leadership through communication.

PMID- 1028695
TI  - Spotlight on the staff. Volunteer services.

PMID- 1028696
TI  - Management by objectives in a healthcare setting.

PMID- 1028697
TI  - Patient education via TV.

PMID- 1028698
TI  - Management of nursing care: when the patient is dying.

PMID- 1028699
TI  - Spotlight on the staff. Admitting.

PMID- 1028700
TI  - How to turn down job applicants without incurring charges of bias.

PMID- 1028701
TI  - Care of the aged: inside and outside the nursing home.

PMID- 1028702
TI  - Spotlight on the staff. Medical records.

PMID- 1028703
TI  - Management of nursing care. Structure: from hierarchy to matrix.

PMID- 1028705
TI  - Group dynamics: working for you or against you?

PMID- 1028704
TI  - The power of suggestion.

PMID- 1028706
TI  - When two health facilities merge: a case study.

PMID- 1028707
TI  - Spotlight on the staff. Social service.

PMID- 1028708
TI  - Management of nursing care: the ingredients of good supervision.

PMID- 1028709
TI  - Art for the patient's sake.

PMID- 1028710
TI  - The woman supervisor: problems and challenges.

PMID- 1028711
TI  - MBO: who's using it? who isn't?

PMID- 1028713
TI  - Admissions after the fact.

PMID- 1028712
TI  - Charting the way to better patient care.

PMID- 1028714
TI  - Anger: threat to managerial control.

PMID- 1028715
TI  - Performance appraisal: an upbeat approach.

PMID- 1028716
TI  - Spotlight on the staff. Central service.

PMID- 1028717
TI  - MBO for nurses.

PMID- 1028718
TI  - Delegation is not abdication.

PMID- 1028719
TI  - Labor relations and the supervisor.

PMID- 1028721
TI  - Management of nursing care: quality care in a small facility.

PMID- 1028720
TI  - Spotlight on the staff. Pharmacy.

PMID- 1028722
TI  - Healthcare on wheels.

PMID- 1028723
TI  - Self-appraisal: tool for managerial development.

PMID- 1028724
TI  - Correlation between plasma growth hormone and insulin and blood glucose
      concentrations in premature infants.
AB  - Plasma growth hormone, insulin and blood glucose levels were measured
      longitudinally during the first 60 days of life in 21 premature infants (8 males
      and 13 females) born between the 6th and 8th month of gestation. When these
      variables were related to age it was found that insulin and glucose, which are
      lower than in the prepubertal children and adults, rise simultaneously. Whereas
      growth hormone, which is higher than in older prepubertal children, decreases
      during the first 2 weeks of life. The decrease in growth hormone continues during
      the first 2 months of life, in contrast to the increases in insulin and glucose
      which do not persist in as long a period.

PMID- 1028725
TI  - Binding of methyltrienolone to various androgen-dependent and androgen-responsive
      tissues in four animal species.
AB  - Comparative sucrose gradient studies of the in vitro binding of
      dihydrotestosterone (DHT) and of a synthetic androgen, methyltrienolone (R 1881),
      have been done with the cytosols of various tissues of the rat, mouse, cock and
      man. With rat prostate cytosol, the amount of R 1881 and DHT binding in the 8-9S
      region of the gradient was found to be comparable. Specific 8-9S peaks of R 1881
      were also found in rat levator ani/bulbocavernosus and skeletal muscles and in
      the mouse kidney. Only 4-5S peaks could be demonstrated in the cock's comb while
      DHT under the same conditions showed both 8-9S and 4-5S binding. Binding of R
      1881 to the cytosol of the hyperplastic prostate was polydispersed, and showed
      evidence of the presence of aggregates. Evidence was also found that R 1881 could
      bind to the progesterone receptor in rat uterus. Our study supports the theory
      that in a given species the androgen receptors are similar if not identical in
      all the tissues. The synthetic androgen R 1881 appears to be a useful tool for
      androgen receptor studies in various animal species provided that the tissue
      under study contains no progesterone receptor.

PMID- 1028726
TI  - The role of calcium in glucagon release. Interactions between arginine and
      calcium.
AB  - The interrelationship between arginine and calcium in glucagon release was
      studied using the in vitro perfused rat pancreas. In the presence of a normal 2
      mM calcium concentration, 10 mM arginine provoked biphasic glucagon release, the
      amplitude of such a response being inversely related to the glucose concentration
      of the perfusate. At the lowest 3.3 mM glucose concentration, and after prolonged
      (40 min) as well as short (10 min) periods of calcium deprivation, arginine
      induced glucagon release was inhibited. These results clearly indicate that
      calcium is necessary for either the recognition or effectiveness of arginine as a
      stimulus to the alpha-cell. Taking into account this, as well as other data
      presently available in the literature, it is suggested that calcium plays a
      versatile role - permissive, inhibitory and stimulatory - in glucagon secretion.
      The intimate mechanisms by which calcium exerts such versatile actions in the
      alpha-cell remain to be elucidated.

PMID- 1028727
TI  - Growth hormone in blood sampled continuously during pentobarbitone-induced sleep
      in children.
AB  - Growth hormone has been estimated in blood sampled continuously in periods each
      lasting 30 min during the first 3-4 h of pentobarbitone-induced sleep in 69
      children. With only two half-hour samples, almost the same information was
      obtained as with the estimation of growth hormone in all samples. In this way 95%
      of normally growing children showed growth hormone levels of 5 muU/ml of more.
      Children with growth retardation of unknown cause and overweight children showed
      on the average lower growth hormone levels, not rarely even below 5 muU/ml.
      Pituitary dwarfs all had maximum growth hormone levels of 3 muU/ml or less.
      Growth hormone levels during sleep may be normal in children who show negative
      results on provocation, while subnormal growth hormone levels during sleep have
      been encountered in some children with retarded growth who had a normal response
      upon provocation.

PMID- 1028728
TI  - Statistics sans mystique.

PMID- 1028730
TI  - Rotary filing record for St Thomas's Hospital.

PMID- 1028729
TI  - Physiotherapy at ground level.

PMID- 1028731
TI  - Hospital cheeses.

PMID- 1028733
TI  - Feasibility of freeze production catering.

PMID- 1028732
TI  - Kitchen hygiene. All that glitters is not clean.

PMID- 1028734
TI  - Dietetics and menu planning.

PMID- 1028735
TI  - Fuelling the kitchen electricity.

PMID- 1028736
TI  - Initiatives in equipment for the elderly.

PMID- 1028737
TI  - Minicomputer installation.

PMID- 1028738
TI  - A new concept in intubation.

PMID- 1028739
TI  - Designer's Prize.

PMID- 1028741
TI  - Catering systems--the nurse's view.

PMID- 1028740
TI  - Research grants.

PMID- 1028742
TI  - Pepping-up hospital meals.

PMID- 1028743
TI  - Efficiency in the hospital pharmacy.

PMID- 1028744
TI  - Stake theory as an explanatory device in Navajo alcoholism treatment response.

PMID- 1028745
TI  - Sociocultural factors in the intergroup perception of health problems: a case of
      grower attitudes toward their migrant labor.

PMID- 1028746
TI  - Becoming a street addict.

PMID- 1028747
TI  - A long day's journey to health care.

PMID- 1028748
TI  - Infant feeding and its effect on growth and development of children.

PMID- 1028749
TI  - Serum vitamin A level of secondary school children.

PMID- 1028750
TI  - Congenital hypertrophic pyloric stenosis.

PMID- 1028751
TI  - Aplastic anaemia in children. A report of three cases.

PMID- 1028752
TI  - Duplication cysts of the gastroinestinal tract. Report of two cases.

PMID- 1028754
TI  - How to start a CME study group for staff physicians.

PMID- 1028753
TI  - The patient's right to refuse treatment.

PMID- 1028755
TI  - Changing relationships between hospitals and health professionals.

PMID- 1028756
TI  - The rights of physicians and hospitals in due process.

PMID- 1028757
TI  - Confidentiality, peer review, and the law.

PMID- 1028758
TI  - Do physicians over 50 belong in active hospital practice?

PMID- 1028760
TI  - AHA delegates applaud strong leadership role for hospitals.

PMID- 1028759
TI  - Bylaws by law: a look at the St. John's decision.

PMID- 1028761
TI  - Views from the chairman. On going full time.

PMID- 1028762
TI  - Medical staff wins in bylaws dispute, but the problem lingers on.

PMID- 1028763
TI  - Critical care: a classification system for ICU patients.

PMID- 1028764
TI  - The legal aspects of a patient care classification system.

PMID- 1028765
TI  - The JCAH: an assessment of strengths, needs, intentions.

PMID- 1028766
TI  - Physicians as diagnosticians--a critical variable in hospital costs.

PMID- 1028767
TI  - AMA does an about-face on collective bargaining.

PMID- 1028768
TI  - Can malpractice insurance be a condition of staff membership?

PMID- 1028769
TI  - The challenge of recertification.

PMID- 1028770
TI  - The 'disorganized' medical staff.

PMID- 1028771
TI  - A legislative solution to the problem of physician discipline.

PMID- 1028772
TI  - Malpractice: funding emerges as a critical issue.

PMID- 1028773
TI  - Identifying unfit physicians--the hospital's responsibility.

PMID- 1028774
TI  - Florida's answer to the problem of professional incompetence.

PMID- 1028775
TI  - Two states strengthen laws aimed at identifying disabled physicians.

PMID- 1028776
TI  - Washington memo: quality assurance programs.

PMID- 1028777
TI  - JCAH: 'saint' or 'sinner'?

PMID- 1028778
TI  - AMA congress confronts issues of credentials, continuing education.

PMID- 1028779
TI  - Physician rehabilitation: a better alternative to punishment.

PMID- 1028780
TI  - The 'privileges' problem.

PMID- 1028781
TI  - Hospital-physician relations: the climate is improving.

PMID- 1028782
TI  - Primary care for the patient who needs it.

PMID- 1028783
TI  - Research with human subjects: the medical staff's responsibility.

PMID- 1028784
TI  - The triclofos mutiny.

PMID- 1028785
TI  - Receipt of prescription is an implied contract.

PMID- 1028786
TI  - Pharmacy technician training program at a Veterans Administration hospital.

PMID- 1028787
TI  - A questionnaire for manufacturers provides useful data on new drugs.

PMID- 1028788
TI  - Continuing pharmaceutical education: I. A way to better patient care.

PMID- 1028789
TI  - Losing control of a computerized formulary.

PMID- 1028790
TI  - The National Drug Code system: its purpose and potential.

PMID- 1028791
TI  - Justification of unit-dose: legal protection plus patient benefits.

PMID- 1028792
TI  - Continuing pharmaceutical education: II. Protection against malpractice suits.

PMID- 1028793
TI  - A Christmas fable.

PMID- 1028794
TI  - A plan for pharmacist-conducted patient discharge interviews.

PMID- 1028795
TI  - Automatic stop orders: an essential part of hospital policy.

PMID- 1028796
TI  - Quality assurance for medical products: unified program for all federal agencies.

PMID- 1028797
TI  - FDA problems with medications in the marketplace: III. 'Therapeutic orphans'.

PMID- 1028798
TI  - A stillness in the Senate hearing room.

PMID- 1028799
TI  - The challenge and promise of pharmacy in the future.

PMID- 1028801
TI  - Need for an international standardized system of lot or batch numbers.

PMID- 1028800
TI  - The enormous task of total formulary review.

PMID- 1028802
TI  - Drug-caused potassium loss in nursing home patients.

PMID- 1028803
TI  - One hospital's guide for the provisional selection of antibiotics.

PMID- 1028804
TI  - A very tight formulary can work if it has a built-in escape valve.

PMID- 1028805
TI  - What P&T Committee members need to know.

PMID- 1028806
TI  - "Primum non nocere"--First do no harm.

PMID- 1028807
TI  - Financing comprehensive pharmaceutical services: how to swim with sharks.

PMID- 1028808
TI  - The pharmacist's role in team treatment of patients receiving injectable long
      acting fluphenazine.

PMID- 1028810
TI  - Designing a modern hospital pharmacy.

PMID- 1028809
TI  - Questions to the consultant pharmacist on standards, accreditation and survey
      inspection.

PMID- 1028811
TI  - IV infusion pumps: the pharmacist's role.

PMID- 1028812
TI  - Contemporary pharmacy services in the small hospital.

PMID- 1028813
TI  - Can the pharmacist solve drug problems in hospitals and still stay afloat.

PMID- 1028815
TI  - Report of the Task Force on Fees for Accreditation.

PMID- 1028814
TI  - A survey of hospital drug purchases and inventories.

PMID- 1028816
TI  - Radioactive vitamin B12 absorption studies in various gastrointestinal disorders.

PMID- 1028817
TI  - Stool weights and transit time in North Indians.

PMID- 1028818
TI  - Peritoneal dialysis in children.

PMID- 1028819
TI  - Changes in blood sugar and osmolality during dialysis with glucose free dialysis
      solution.

PMID- 1028820
TI  - Some metabolic facets of magnesium in diabetes mellitus.

PMID- 1028821
TI  - Observations on serum immunoglobulin and complement fractions in rheumatoid
      arthritis.

PMID- 1028822
TI  - C.S.F. in diabetic neuropathy--revisited.

PMID- 1028823
TI  - Methyldopa liver injury.

PMID- 1028824
TI  - Use of glucose free dialysate for haemodialysis.

PMID- 1028825
TI  - Dialysing uremic children.

PMID- 1028826
TI  - Gas cysts of intestine.

PMID- 1028827
TI  - Ascites of undetermined origin in patients with pneumatosis cystoides
      intestinalis.

PMID- 1028828
TI  - Arsenic encephalopathy (a report of two cases).

PMID- 1028829
TI  - The biomedical equipment technician.

PMID- 1028830
TI  - The hospital instrumentation department: delivering clinical engineering services
      to the hospital community.

PMID- 1028831
TI  - The cost of a clinical engineering department.

PMID- 1028832
TI  - Preventive maintenance program at Lutheran Hospital of Maryland.

PMID- 1028833
TI  - Plugs and receptacles in the hospital: a compendium for the clinical engineer.

PMID- 1028834
TI  - Professional engineering registration and clinical engineering.

PMID- 1028835
TI  - Are dead-front (hospital grade) plugs as safe as the molded type?

PMID- 1028837
TI  - Directory of local & regional biomedical organizations.

PMID- 1028836
TI  - A specialist/generalist peer group certification system.

PMID- 1028843
TI  - Propositions and pilgrimage.

PMID- 1028844
TI  - Journey of a pastoral counselor.

PMID- 1028845
TI  - AAPC constitution revision: a challenge to integrate function and form.

PMID- 1028846
TI  - Pastoral counselors licensing bill in New Hampshire: realities and issues.

PMID- 1028847
TI  - The healing of memories: psychotherapeutic ritual among Catholic pentecostals.

PMID- 1028848
TI  - Nurturing the souls of black folk.

PMID- 1028849
TI  - Pastoral counseling and the black perspective.

PMID- 1028850
TI  - Toward a therapy of being.

PMID- 1028851
TI  - Responses of single units in the cat cochlear nucleus to sinusoidal amplitude
      modulation of tones and noise: linearity and relation to speech perception.
AB  - Responses to the sinusoidal modulation envelopes of amplitude-modulated tonend
      noise carriers were recorded from  single units in the cochlear nucleus of the
      cat. The unit discharges were synchronized to the peaks of the modulation
      envelope. Population-averaged firing rate were independent of the modulation
      index of the stimulus. Temporal firing patterns, as represented by the shapes and
      magnitudes of modulation-cycle histograms, were strongly dependent on stimulus
      intesity and modulation index. Nonlinear nonsinusoidal responses to sinusoidal
      modulation envelopes were observed, but only at high values of sound intensity.
      These and other results are discussed in the context of psychological studies
      concerning the perception of speech information.

PMID- 1028852
TI  - In vitro vs in situ development of Purkinje cells.
AB  - Analysis of in vitro vs in situ development of Purkinje cells was undertaken in
      order to compare the transitory morphology of Purkinje cells grown in situ with
      their differentiation in vitro. Purkinje cells in rotary cultures developed their
      basic morphological pattern only when the cultures were prepared from 16-day
      chick embryos, indicating the existence of a critical period during their normal
      differentiation, which lasted approximately 24 hr between days 14 and 15
      embryonic development.

PMID- 1028853
TI  - Brain colchicine-binding protein (tubulin) during postnatal development in the
      rat.
AB  - A time-decay colchicine-binding assay was used under optimal conditions for
      measuring tubulin concentration in the cerebral cortex and cerebellum during
      postnatal development. In both brain areas soluble tubulin concentration (pmoles
      colchicine bound/mg tissue) declined by about 35% between 4 and 12 days of age
      after which the decrease was more gradual up to adulthood. Colchicine-binding
      protein concentration of particulate fractions, on the other hand, increased
      between 4 and 12 days of age followed by relatively little change. The
      concentration of tubulin in the soluble and particulate fractions of the cerebral
      cortex was 45% and 75% greater, respectively, than corresponding fractions of the
      cerebellum. The expression of tubulin on the basis of DNA, revealed marked
      regional differences which can be considered a reflection of differences in the
      relative extent of morphological differentiation in these areas during the
      postnatal period. Tubulin in both soluble and particulate fractions exhibited a
      marked increase in lability for colchicine binding from approximately 12 days of
      age. The half-life for loss of colchicine-binding activity was 2,5-fold greater
      in particulate compared to soluble fractions. An analysis of the characteristics
      of the particulate colchicine-binding reaction provides additional support for
      the hypothesis that it represents a functionally significant association of
      tubulin with the membranous components.

PMID- 1028854
TI  - Failure to demonstrate alterations in gluconeogenesis in growth-retarded weanling
      rats with dorsomedial hypothalamic lesions.
AB  - Bilateral electrolytic lesions were placed in the dorsomedial hypothalamic nuclei
      (DMN) of weanling male Sprague-Dawley rats. Sham-operated rats served as
      controls. After 22 days on lab chow and tap water ad libitum, the animals were
      injected with U-14 C-alanine 0.167 muC/mu moles intraperitoneally (5 muC and 30
      mu moles/100 gm body weight) and sacrificed 2 hr later. There was no significant
      difference, in the incorporation of the label into total lipid, free fatty acids,
      glycogen, or tissue protein of both liver and diaphragm, between the DMN-lesioned
      and the sham-operated rats. Similarly, there was no significant difference in the
      incorporation into plasma glucose or protein. It is concluded that in spite of
      profound alterations in both ponderal and linear growth and food intake, there is
      no disruption of normal gluconeogenesis in the weanling rat with DMN lesions.

PMID- 1028855
TI  - Effect of acetylcholine on the activity of dopamine beta-hydroxylase in rat
      brain.

PMID- 1028856
TI  - Changes of CTP synthetase activity during postnatal rat brain development.
AB  - The activity of CTP synthetase (UTP: ammonia ligase (ADP, EC. 6.3.4.2.) was
      determined in rat cerebral hemispheres and cerebellum during postnatal
      development. It was found that enzyme activity, when expressed per unit of
      protein or wet tissue weight, in both parts of the brain decreased with age, the
      diminution proceeding more rapidly in the cerebellum than in the hemispheres.
      When CTP synthetase was expressed on the basis of DNA an activity peak in the
      hemispheres with a maximum on the 5th day after birth was observed. The enzyme
      content per cell was several times lower in the cerebellum than in the
      hemispheres at each age studied, with the exception of 1-day-old animals, in
      which both tissues displayed similar activity. The results obtained were compared
      with literature data for the intensity of RNA synthesis in the developing brain.
      The conclusion was reached that the changes of CTP synthetase activity were
      closely related to the RNA metabolism. Therefore the enzyme under study may be
      one of the factors involved in cell control of RNA synthesis.

PMID- 1028857
TI  - Structure of neuronal assemblies in cerebral cortex.
AB  - Interrelations in the apical dendrite bundles of a single neuronal column were
      revealed by means of light and electron microscopy in the cat motor cortex. Such
      column presents an integrated structural module. There were also found wider
      joinings of several columns, among which complex coordination may exist.

PMID- 1028858
TI  - The relationship of afterhyperpolarizations of extraocular motoneurons to
      membrane potential.
AB  - The effect of membrane potential displacements caused by external current
      injection on the amplitudes of two antidromically evoked afterhyperpolarizations
      (AHP1 and AHP2) was measured in extraocular motoneurons. AHP1 had a reversal
      potential of-70mV and an average compensation for displacements from the reversal
      potential ("compensation gain") of -0.36. AHP2 had a reversal potential of-80mV
      and a compensation gain of -0.08. Measurements of input resistance of these
      motoneurons demonstrate a 30-50% decrease at depolarized membrane potentials.
      This rectification could account for the apparent lack of summation of AHP2. The
      functional role of AHP1 and AHP2 in the regulation of discharge frequencies of
      extraocular motoneurons during nromal eye movements is discussed.

PMID- 1028859
TI  - Response of a brain protein fraction 24 hours after training in rats.
AB  - The aim of the study was to follow the amount and incorporation of 14C-valine
      into separate, soluble protein fractions of the hippocampus, thalamus, and visual
      cortex of rats from 0 to 72 hr after training. The behavioral test consisted of
      reversal of handedness with training twice daily for 25 min for 2 days, followed
      by a 5-day intermission without training, and a final session of 24 min. The
      animals were injected intraperitoneally with 14C-valine 30 min before sacrifice
      and taken 0, 24, 48, and 72 hr after last training. After 24 hr, and only at that
      time, double incorporation values and increased amounts were observed in a
      protein fraction, No. 6 from the front, in all three brain areas of the trained
      rats compared to active controls. At 48 hr this protein fraction was at control
      level.

PMID- 1028860
TI  - Effects of local illumination of the hypothalamus on spontaneous and flash
      induced multiunit activity recorded from the gonadotropic hypothalamic areas in
      quail.
AB  - Multiple unit activity (MUA) was obtained from gonadotropic areas of the
      hypothalamus in quail. Pellets of radioluminous paint (RLP) were implanted
      unilaterally either in the nucleus tuberis or in the n. posterior medialis
      hypothalami. Control data were obtained from birds receiving nonluminous material
      (RP). Spontaneous MUA was decreased by 25% in gonadotropic arease in RLP-treated
      quail. Direct permanent photostimulation of hypothalamic neuronal population was
      not as effective in decreasing MUA as environmental photostimulation (50%).
      Activation in firing rates, which was constant in nonphotostimulated intact birds
      in response to repetitive flash-light stimulations, was completely suppressed
      after implantation of RLP.

PMID- 1028861
TI  - The study of platelet microtubule assembly.

PMID- 1028862
TI  - A case report: a giant prostatic leiomyoma.

PMID- 1028863
TI  - Studies on cryosurgical treatment of chronic cervicitis.

PMID- 1028864
TI  - Biological effects of exposure to lead in ambient air among Tokyo inhabitants.

PMID- 1028865
TI  - A comparison of oral and written code elaboration.

PMID- 1028866
TI  - Lexical derivation and the form class of word associations.

PMID- 1028867
TI  - The role of syntax in sentence recall.

PMID- 1028868
TI  - The effect of level of education on judgments of grammatical acceptability.

PMID- 1028869
TI  - The meaning of frequency words in different contexts.

PMID- 1028870
TI  - Elicited imitation of language: some ESNS population characteristics.

PMID- 1028871
TI  - Elicited imitation and assessment of abilities.

PMID- 1028872
TI  - Attribution processes and interpersonal accommodation in a bilingual setting.

PMID- 1028873
TI  - [Pathogenesis of chronic pancreatitis (author's transl)].
AB  - The earliest change during chronic pancreatitis seems to be precipitation of
      proteic material consisting apparently of the normal components of pancreatic
      juice, as demonstrated by pathology studies. Similar changes could be induced in
      animal experiments. There seems to be a causal relationship between increased
      protein concentration in pancreatic juice and protein precipitation. The cause of
      the disease in most cases is alcoholism combined with a diet rich in fat and
      proteins, or malnutrition in infants. The mechanism of action was clarified in
      dogs and rats: An increase of cholinergic stimulation influencing pancreatic
      secretion directly seems to be involved as well as an indirect stimulation of
      pancreatic secretion by gastroduodenal hormones.

PMID- 1028874
TI  - [Diagnosis and differential diagnosis of pancreatitis--diagnostic relevance of
      clinical and biochemical changes during the course of the disease and of
      endoscopic retrograde pancreatography (author's transl)].
AB  - In order to classify a patient with pancreatitis according to the Marseille
      clasiffication the following criteria must be fulfilled: (a) an acute attach of
      pancreatitis must be observed, (b) the cause of pancreatitis has to be
      established, (c) the patient has to be followed over longer periods of time in
      order to find out, whether the process becomes chronic (involving progredient
      endocrine and exocrine insufficiency). Diagnostic problems of acute pancreatitis,
      relapsing pancreatitis, and chronic pancreatitis are discussed taking into
      account the author's own results. It is concluded, that repeated tests of
      pancreatitis function and demonstration of pancreatic calcification are more
      important for establishing the diagnosis of chronic pancreatitis than studies of
      pancreatic morphology including endoscopic retrograde pancreatography (ERP). ERP
      may help to find the cause of relapsing pancreatitis of unknown origine; it may
      help as well preoperatively to diagnose local changes of the pancreatic duct
      system in chronic pancreatitis.

PMID- 1028875
TI  - [Diagnostic relevance of provocative (evocative) blood enzyme tests in pancreatic
      disease (author's transl)].
AB  - After a review of the literature the author's results of testing pancreatic
      function in 445 patients with different diseases are reported. The activities of
      serum amylase and lipase were estimated before and after stimulation with
      secretin and pancreozymin; at the same time exocrine secretions of the pancreas
      were collected in the duodenum and analyzed. Serum enzyme activity did not change
      markedly after stimulation in pronounced pancreatic insufficiency. Measuring the
      enzyme activity thus helped to make the diagnosis only in a few cases with
      chronic pancreatitis and pancreatic carcinoma. In all other patients there was no
      correlation between changes of serum enzyme activities and changes of exocrine
      pancreatic function. Pathological test results, that means an increase in enzyme
      activity after stimulation, were found not only in patients with established or
      suspected pancreatic diseases, but also in many other subjects. Thus the
      diagnostic relevance of these tests seems to be rather limited, since it does not
      prove or exclude with sufficient specificity or adequate probability the presence
      of pancreatic diseases; it therefore cannot be recommended for screening
      purposes.

PMID- 1028876
TI  - [Pancreatitis and papillary stenosis: endoscopic retrograde pancreatography (ERP)
      vs. exocrine functional tests (author's transl)].
AB  - Functional tests and ERP were performed in patients with chronic and acute
      pancreatitis and papillary stenosis; both diseases differ considerably as can be
      shown by both, pancreatography and degree of functional impairment. The different
      classification types of pancreatitis are based upon the Marseille Symposium. The
      ERP is the only x-ray procedure which allows the diagnosis of intrapapillar
      pancreatic duct stenosis. The ERP significantly improves diagnosis of the early
      stages of papillary stenosis of the pancreas. Neither secretin-pancreozymin test
      nor ERP are indicated in cases of primary chronic calcifying pancreatitis; in
      chronic relapsing calcifying pancreatitis they should be used for preoperative
      diagnostic purposes.

PMID- 1028877
TI  - [Hyperlipoproteinemia and pancreatitis (author's transl)].
AB  - Exocrine pancreatic function was tested in 8 patients with pancreatitis and
      hyperlipoproteinemia type I, IV and V. Three young patients with HLP I and V and
      2 patients with alcoholic HLP type V exhibited in most cases a distinctly reduced
      pancreatic function (chronic relapsing pancreatitis). Three patients with primary
      or secondary HLP type IV and V did not present pancreatic insufficiency (acute
      pancreatitis, acute relapsing pancreatitis). Taking into account the literature
      data and our own experience it can be stated that all forms of excessive
      hypertriglyceridemia can give rise to acute pancreatitis. Different possible
      causal relationships between HLP and pancreatitis are discussed. Concomitant
      occurrence of HLP and pancreatitis is observed most often in alcoholics.

PMID- 1028878
TI  - The design and use of a veterinary medical record.

PMID- 1028880
TI  - How to work less and accomplish more.

PMID- 1028879
TI  - Exploring curriculum relevance & local market conditions for MRTs.

PMID- 1028881
TI  - Unitization of records in a small hospital.

PMID- 1028882
TI  - One hospital's approach to word processing.

PMID- 1028883
TI  - A helping hand in Afghanistan.

PMID- 1028884
TI  - A reason for visit classification system for ambulatory care.

PMID- 1028886
TI  - The value of a disease index in a nursing facility.

PMID- 1028885
TI  - The world turned upside down.

PMID- 1028887
TI  - President's message.

PMID- 1028888
TI  - An introduction to organization development for the hospital department head.

PMID- 1028889
TI  - Confidentiality of alcohol and drug abuse patient records, part II.

PMID- 1028890
TI  - Suicide and Islamic law.

PMID- 1028891
TI  - Ethical norms of suicide prevention and crisis intervention.
AB  - Life is not a so called highest value in itself--it is highest value as life
      subdued to the spirit, to the transcendence, as life 'in relation to'. Human
      existence is existence within history which means that it is vocational. If life
      is vocational it has an inborn eschatology. To commit suicide is to stop out of
      one's own history and eschatology, an act devoid of freedom. To help suicidals
      means: to give the suicidal person 'assistance to freedom', helping him to find
      his freedom which is also a freedom to suffer, to live, to believe, to gain
      confidence and to die when death overcomes us.

PMID- 1028892
TI  - Theological reflections on suicide.

PMID- 1028893
TI  - Self-destruction and religion.
AB  - In this paper a brief analysis of the development of the Western world after the
      second world war is attempted. It is stated that since the start of the sixties,
      anomie can be perceived in many of the components of its socio-cultural complex,
      especially in some major areas like the economy and religion, deeply influencing
      the others. To test the assumption that Durkheim's anomie theory is still valid
      and offers an adequate frame of reference for research of the underlying
      phenomena, the outcome of a research on 9.189 completed suicides in the
      Netherlands during the period 1961--1970 is presented, giving force to the
      validity and usefulness of this theory.

PMID- 1028894
TI  - Present status and evaluation of suicide prevention and crisis intervention
      services in Europe.
AB  - The present West-European suicide prevention and crisis intervention services are
      reviewed in the article, which also considers suicide prevention in the light of
      the literature, contains some critical remarks and puts forward certain
      suggestions for further development of the services concerned. It is concluded in
      the article that the present situation is not yet satisfactory as far as suicide
      prevention is concerned, nor is it likely today to be satisfactory in many
      countries in respect of crisis intervention.

PMID- 1028895
TI  - On suicide.

PMID- 1028896
TI  - Some data on suicide and attempted suicide of the Jewish population in Israel.

PMID- 1028897
TI  - Problems associated with culture contact in the psychotherapeutic setting:
      disparity of expectations between the western-trained therapist and the non
      western patient.
AB  - Observations made in this paper are based on work with a group of lower-class
      French-speaking North Africans receiving treatment at a Community Mental Health
      Centre in Jaffo. Experience with this group revealed a fundamental disparity
      between patients' and therapists' expectations from therapy. Patients generally
      expect tangible, quick relief and regard themselves as passive recipients of a
      procedure: therapists hope for some form of participation on the patients' part
      and view treatment as a slow process. Patients' expectations appeared to derive
      from basic features of their personalities. It is hypothesized that members of
      this group are 'psychologically undifferentiated': thus, among other things, they
      have poorly-developed identities, lack self-direction and stereotype themselves
      as subordinate beings, acted upon by authority figures. The present approach
      differs from the usual attitude adopted towards patients of this kind since it
      argues that it is possible to foster independence amongst them. It is proposed
      that this can be done only if the patient is regarded as an active participant in
      the therapeutic experience and if one uses the clinical situation as a
      fundamental learning experience. On a more general level, it is speculated that
      the observations and analysis presented here are not specific to the ethnic group
      dealt with, but are applicable to any disadvantaged lower-class group.

PMID- 1028899
TI  - Social psychiatric implications of population control in Indonesia.

PMID- 1028898
TI  - Social sychiatric implications of population control in Thailand.

PMID- 1028900
TI  - Socio-cultural modalities in population control.
AB  - Overpopulation with its identifiable and noxious results, is probably the most
      ominous and potentially destructive condition existing in current world society.
      The etiology of this problem includes the failure of mankind to develop
      compatible interrelationships between members of his own family, clan, society,
      and world population. The author predicts that all efforts to achieve world
      population control will be essentially ineffective unless the insights of the
      holistically oriented science of social psychiatry are refined into principles
      and rules which direct population control endeavors. This paper reviews the
      extent and severity of the problem and stresses the need for the operational
      implementation of the value systems and methodologies of social psychiatry. The
      author believes that effective population control is possible if the actions of
      world leaders are directed toward efforts to achieve satisfaction of the basic
      (Ur) needs of all individuals and groups for physical survival, socialization,
      and transcendence.

PMID- 1028901
TI  - Bad tidings and the hospitalized patient.
AB  - The physician in hospital practice may be faced with a situation in which a
      patient under his care suffers a bereavement or some other unexpected tragedy but
      is unaware of the fact. Three such cases encountered in the context of our
      psychiatric sonsultation service are presented. Factors influencing the decision
      as to whether, when and how the patient should be informed are considered. The
      complex psychodynamic situation which arises and involves the patient, his family
      and the medical staff is described. Stress is laid on the role played by archaic
      fears of being the bearer of evil tidings. The situation is seen as being ideally
      handled by the direct treating physician in conjunction with the family, the
      extent of psychiatric intervention being dictated by the needs of each of the
      parties concerned. Ideally the patient should be told as soon as his physical and
      mental condition are seen as conducive and preferably before he leave hospital.

PMID- 1028902
TI  - Residential schools as powerful environments.
AB  - This article attempts to make a preliminary classification of some of the
      theoretical material published in the last two decades which led to the emergence
      of a new area in educational research, that of residential education. This has
      come in response to the increasing frequency of placement in residential settings
      as a means of educating adolescents.

PMID- 1028903
TI  - Student theatre as a means of promoting communication, self-development and
      creativity.
AB  - In the process of producing plays in a student drama and theatre workshop at the
      Hebrew University of Jerusale, certain educational principles and techniques have
      been utilized. These principles appear to promote inter-group communication, as
      well as self-development and creativity and to provide a vital educational
      technique in the teaching of literature.

PMID- 1028904
TI  - Theatre and community: 'the Tent of Joseph'.
AB  - The rationale of community theatre is discussed and its mental health and social
      goals set forth; these are the mobilisation of creativity through the
      construction of an original community drama and, impelled by this and its
      performance, activity for community organisation. An original project in Israel
      and its first stages of implementation are reported and analysed.

PMID- 1028905
TI  - Growth and ultrastructure of Streptomyces venezuelae during chloramphenicol
      production.
AB  - Streptomyces venezuelae (3022a) was grown in flask cultures and fermentors, using
      three media having differential effects on chloramphenicol production.
      Micromorphology, ultrastructure and chloramphenicol concentrations were studied
      during the growth cycle in each medium. Chloramphenicol production was greatest
      in the glycerol-serine-lactate (GSL) medium, less in the glycerol-nutrient broth
      yeast extract (GNY) medium and very low in glucose-mineral salts (GA) medium. In
      GSL and GA, much growth was in the form of microcolonies, especially in flask
      cultures, while short hyphal fragments predominated in GNY. The major
      ultrastructural features were the high frequency of mesosomes in fragmenting
      hyphae in GNY, and electron-transparent zones which appeared during
      chloramphenicol synthesis in GSL. None of the structural abnormalities induced by
      chloramphenicol in sensitive organisms were observed in S. venezuelae despite
      high levels of the antibiotic in GSL medium.

PMID- 1028906
TI  - Fatty acid profiles of Streptococcus mutans NCTC 10832 grown on synthetic mediun
      with sucrose, fructose or sorbitol.
AB  - Streptococcus mutans NCTC 10832 was grown on synthetic medium in a chemostat,
      using various major carbon sources, viz, sorbitol, fructose and sucrose. Freeze
      dried cells were methylated and the methyl esters analysed by GLC. The fatty acid
      profiles obtained showed small quantitative change with different sugars, sucrose
      concentrations and types of growth.

PMID- 1028907
TI  - [Vital events in the field of health and health insurance].

PMID- 1028908
TI  - [Methods and problems in processing health statistics information].

PMID- 1028909
TI  - [Use of registries in medical studies with special regard to experiences in
      registration of neoplasms].

PMID- 1028910
TI  - [System of binding information of relation to the individual].

PMID- 1028911
TI  - [Statistical indicators of the population health state and achievements of
      preventive medicine].

PMID- 1028912
TI  - [Basic principles in statistics of human environment].

PMID- 1028913
TI  - [Statistics in industrial medicine].

PMID- 1028914
TI  - [Statistics of health safety of food and objects in general use].

PMID- 1028915
TI  - [Statistics in the field of ionizing and microwave radiation].

PMID- 1028916
TI  - [Statistics of medical causes of traffic accidents].

PMID- 1028917
TI  - [Follow-up of consumption of drugs and its inclusion into the health information
      system].

PMID- 1028918
TI  - [Problems of health insurance concerning drug traffic and drug consumption].

PMID- 1028919
TI  - [Documentation and control of drug traffic and consumption].

PMID- 1028920
TI  - [Statistical standards: use of standard definitions, classification, nomenclature
      and other elements of statistical methodolgy-prerequisites of comparative
      information].

PMID- 1028921
TI  - [Preparation of a pharmacy introduction of new control system concerning the
      traffic and supply of drugs and narcotics].

PMID- 1028922
TI  - [Experiences in preparation of a pharmacy for introduction of a new system of
      reporting drug traffic and drug consumption].

PMID- 1028923
TI  - [Experiences in the preparation of hospital pharmacies for the introduction of a
      new system reporting on the traffic and consumption of drugs].

PMID- 1028924
TI  - [Analysis of the traffic and consumption of drugs in the automatic data
      processing].

PMID- 1028925
TI  - [Automatic processing of drug traffic and consumption in pharmacies].

PMID- 1028926
TI  - [Program of regular statistical education of medical personnel with middle,
      higher and graduate education: status and needs. Program of directed statistical
      education in periodical courses and seminars for health personnel].

PMID- 1028927
TI  - [Organization of education of the health statistician-prerequisite for effective
      statistical work].

PMID- 1028928
TI  - [Systematic approach to post-diploma education of highly qualified health
      personnel in production and use of statistical health information].

PMID- 1028930
TI  - [Energy metabolism of skeletal muscle during a deficit in excitation].

PMID- 1028929
TI  - [Neuronal activity of the primary chemoreceptor center in fish during acid and
      salt stimulation of the cutaneous surface].

PMID- 1028931
TI  - [Structural and functional charateristics of an individual neurorsceptor cell].

PMID- 1028932
TI  - [Fine structure of the afferent nerve of the proprioceptive PD-organ of the claw
      of the creyfish Astacus astacus].

PMID- 1028933
TI  - [Effect of cationic proteins from the brain and thymus on hydrolase release from
      neutrophils].

PMID- 1028934
TI  - [Effect of succimer on the intensity of pyruvate and lactate oxidation in the
      brains of rats poisoned with mercuric chloride].

PMID- 1028935
TI  - [Principle of the dominant in interneuronal interaction].

PMID- 1028936
TI  - [Principle of disequilibrium (asymmetry) in the principle of the dominant as
      applied to the theory of work capacity].

PMID- 1028937
TI  - [Paradoxic effects of strong stimuli and physical electrotomus].

PMID- 1028938
TI  - [Influence of the anterior and posterior hypothalamus on cerebral cortex evoked
      potentials].

PMID- 1028939
TI  - [Comparative study of the mechanisms of closing a temporal connection].

PMID- 1028940
TI  - The ventricular system in hydrocephalic chick brains induced by cyclophosphamide.

PMID- 1028941
TI  - Electroencephalographic study of sleep in organic brain damage.

PMID- 1028942
TI  - Centrally mediated idiopathic orthostatic hypotension. A case of Shy-Drager
      syndrome.

PMID- 1028943
TI  - Intradural spinal lipoma.

PMID- 1028944
TI  - Ischemic myelopathy in aortic occlusive disease.

PMID- 1028945
TI  - Choroid plexus carcinoma--a case report.

PMID- 1028946
TI  - Early changes in the ultrastructure of the pars intermedia of the pituitary of
      Xenopus laevis after change of background color.
AB  - Stereological analysis of the secretory cells of the pars intermedia of Xenopus
      laevis over a period of 3 days following the transfer of animals from a white to
      a black background has revealed that significant alterations in the
      ultrastructural appearance of these cells can be detected 8 h after the transfer.
      In particular, changes in the secretory granules and the rough endoplasmic
      reticulum were found to correlate well with previous reports concerning the
      melanocyte-stimulating hormone (MSH) content and the capacity for protein
      synthesis of the pars intermedia.

PMID- 1028947
TI  - Comparison between hypothalamic, hippocampal and septal multiple unit activity
      and basal corticotropic function in unrestrained, unanesthetized resting pigeons.
AB  - Multiple unit activity (MUA) was obtained from various forebrain regions in
      unanesthetized, unrestrained resting pigeons throughout the whole photoperiod and
      compared with plasma corticosterone levels. The pattern of electrical activity
      recorded from the adrenocorticotropic area of the hypothalamus showed diurnal
      variations which paralleled the plasma corticosterone fluctuations during the 24
      h photoperiod. Both parameters were low in the late afternoon and the evening and
      high in the early morning. Hypothalamic activation slightly preceded the peak o
      corticosteronemia. Conversely, in hippocampal (H) and septal (S) regions, the
      peak of MUA occurred in phase opposition with respect to the hypothalamic peak,
      and there was a marked decrease of firing rates at the moment when
      adrenocorticotropic activation was initiated.

PMID- 1028948
TI  - Metyrapone inhibition of 3H-hydrocortisone uptake and binding in various brain
      regions of the pig.
AB  - Metyrapone (MET) inhibition of hydrocortisone (3H-HC) uptake binding in the
      cytosol and nucleus of various brain regions of the pig was demonstrated in vivo.
      The hippocampus, hypothalamus and septum were the regions most sensitive to the
      inhibition by MET. The hippocampus exhibited the greatest reduction in 3H-HC
      concentration in whole homogenate, bound in cytosol and in nuclei. The anterior
      pituitary and cerebral cortex were the least sensitive to MET. In vitro
      incubation of hypothalami with 3H-HC and MET substantiated the results obtained
      in vivo with regard to the inhibitory action of MET on 3H-HC uptake and binding.
      These results were interpreted to indicate the MET may act directly in certain
      brain regions and that this inhibitory aciton has important implications for both
      experimental and clinical uses of this drug.

PMID- 1028949
TI  - Production of weanling rat ventromedial and dorsomedial hypothalamic syndromes by
      electrolytic lesions with platinum-iridium electrodes.
AB  - Weanling Sprague-Dawley rats received bilateral anodic electrolytic lesions with
      platinum-iridium (PtIr) electrodes in the ventromedial (VMN) and dorsomedial
      (DMN) hypothalamic areas. Sham-operated rats served as controls. The rats were
      maintained for 48 days (experiment 1) and 33 days (experiment 2) and food intake,
      body weight (b.w.), nose-tail length and obesity index were recorded. The data of
      both experiments indicate that all parameters change in the same direction, as
      they do when lesions are produced with anodic stainless steel electrodes: in the
      VMN-P-lesioned animals, b.w. gains and overall mean food intake were normal,
      carcass fat increased and linear growth was reduced. In experiment 2, however,
      there was a temporary hyperphagia during the 1st 2 weeks of the study. In the DMN
      lesioned rats, both ponderal and linear growth and food intake were decreased but
      body composition was normal. Plasma obtained at sacrifice in experiment 2 showed
      slight but significant hyperinsulinemia in the VMN rats (p less than 0.02 vs
      control and p less than 0.05 vs DMN rats). Prolactin (PRL) levels, on the other
      hand, were higher in the DMN-lesioned rats (p less than 0.05 vs control and p
      less than 0.02 vs VMN rats). The data indicate that the changes characteristic of
      the weanling rat VMN and DMN syndrmes are due to 'true' tissue destruction rather
      than to artifactitious side effects of the lesions. They also suggest, therefore,
      than an 'irritative focus' hypothesis is not required to account for the observed
      alterations. They further suggest that the DMN may play role in the control of
      PRL release.

PMID- 1028950
TI  - Autoradiographic localization of estradiol-concentrating cells in the female
      hamster brain.
AB  - Autoradiographic methods were used to study the location of estrogen
      concentrating cells in the brain of the female hamster. In the hypothalamus, well
      labelled cells were reliably found in the posterior medial preoptic area (MPOA),
      the anterior hypothalamus (AHA), and the ventromedial (VM), arcuate (ARC) and
      ventral premammillary nuclei (VPM). In the limbic system, well-labelled cells
      were found in the ventro-lateral septum, bed nucleus of the stria terminalis, and
      the medial and cortical nuclei of the amygdala. Labelled cells, in small numbers,
      were also detected in the mesencephalic central gray (CG), lateral hypothalamus,
      subiculum and entorhinal cortex. The neuroanatomical pattern of estrogen
      concentrating cells in the hamster supports the concept of a generalized
      vertebrate pattern. Furthermore, a comparison of hamster and rat patterns of
      cellular 3H-estradiol (3H-E2) concentration appears to suggest that species
      differences in their responsiveness to estrogen may be paralleled by differences
      in estrogen binding.

PMID- 1028951
TI  - Selective actions of prolactin on catecholamine turnover in the hypothalamus and
      on serum LH and FSH.
AB  - The effects of prolactin (PRL) administration on catecholamine turnover in
      various brain regions of ovariectomized rats were determined by observing the
      decline of dopamine and norepinephrine concentrations after alpha-methyltyrosine
      (alphaMT) administration. PRL had no effect on the steady state concentration of
      dopamine in the median eminence, anterior hypothalamus and corpus striatum or on
      the norepinephrine concentration in the anterior hypothalamus. However, PRL
      selectively enhanced dopamine turnover in the median eminence and anterior
      hypothalamus after a latent period of 10-26 h. In addition, PRL administration
      significantly decreased serum concentrations of LH and FSH. These results suggest
      that the PRL-induced increase in activity of dopaminergic neurons in the median
      eminence or anterior hypothalamus may be responsible for the reduction of the
      post-castration rise in serum concentrations of LH and FSH.

PMID- 1028952
TI  - Effect of ventromedial and dorsomedial hypothalamic lesions on circadian
      corticosterone rhythms.
AB  - Weanling rats received bilateral electrolytic lesions in the dorsomedial (DMH) or
      ventromedial (VMH) hypothalamic areas destroying primarily the dorsomedial (DMN)
      or ventromedial (VMN) hypothalamic nuclei. Sham-operated rats served as controls.
      Lesions in the VMN and DMN, both of which have previously been shown to disrupt
      normal diurnal feeding rhythms, were also observed to disrupt normal plasma
      corticosterone rhythms in the present study. The a.m. values of plasma
      corticosterone in the DMN-lesioned rats were higher than the sham-operated
      controls. In the p.m., the values of both VMN- and DMN-lesioned rats were lower
      than those of the controls but unchanged in comparison to their own a.m.
      concentrations. This disruption of the normal diurnal plasma corticosterone
      rhythm persisted for at least 9 post-operative weeks.

PMID- 1028953
TI  - Ovarian control of gonadotropin secretion during induced precocious sexual
      maturation in the rat.
AB  - In sexually immature female rats 'primed' with a unilateral basal hypothalamic
      lesion on day 23 of life, a gonadotropin surge was triggered by progesterone (P)
      on day 26. The influence of sequential ovariectomy (OVX) on this response was
      studied in an attempt to elucidate the mode of action of brain lesions inducing
      precocious sexual maturation in this species. OVX, carried out on days 23-26,
      abolished or greatly reduced the LH surge, but had little effect on basal LH
      concentrations. In contrast, basal FSH concentrations rose rapidly after OVX. In
      lesioned rats, the post-castration rise of FSH could be prevented by leaving the
      ovaries in place during the 1st 24 or 48 h. It is concluded that the lesion
      induced maturation of the positive feedback mechanism underlying the pubertal
      preovulatory gonadotropin surge is mediated by the ovaries. In prepubertal rats
      at this age, tonic FSH release, but not tonic LH release, is under tight negative
      feedback control.

PMID- 1028954
TI  - Effects of continuous light and darkness, and of pinealectomy, adrenalectomy and
      gonadectomy on uptake of 3H-serotonin by the suprachiasmatic nuclear region of
      male rats.
AB  - Rats exposed to continuous light show no significant differences in serotonin (5
      HT) uptake by the suprachiasmatic nuclear region (SNR) at 10.00 and 22.00 L,
      while in continuous darkness, the uptake at 10.00 D is significantly higher than
      uptake at 22.00 D. In consideration of the role of the suprachiasmatic nucleus in
      light-mediated control of neuroendocrine activity, this suggests endogenous
      generation or control of this uptake rhythm. An effect of sham-pinealectomy in
      decreasing 5-HT uptake was found, but cannot be fully interpreted at this time.
      The lack of effect of castration or adrenalectomy suggests that these endocrines
      have little if any direct effect on 5-HT mechanisms in the SNR.

PMID- 1028955
TI  - Further studies on the effects of adrenergic, serotonergic and cholinergic drugs
      on the afternoon surge of plasma prolactin in ovariectomized, estrogen-treated
      rats.
AB  - The involvement of adrenergic, serotonergic and cholinergic mechanisms in the
      diurnal surge of plasma prolactin (Prl) secretion has been examined using
      ovariectomized, polyestradiol phosphate-treated (PEP) rats bearing aortic
      catheters. An afternoon surge in plasma Prl was observed to peak at 15.00 h and
      17.00 h followed by declining levels at 19.00 and 21.00 h. This pattern was
      observed between 5 and 21 days after PEP administration. The alpha-adrenergic
      blocker, phenoxybenzamine (Phenox), completely prevented the Prl surge. The beta
      blocker, propranolol (Propra), appeared to delay the onset and intensity of the
      diurnal Prl surge so that maximum levels were observed at 19.00 and 21.00 h. The
      serotonergic blocker, methysergide (MES), delayed the maximum diurnal Prl level
      until 21.00 h, while cyproheptadine (Cypro), another serotonergic blocker,
      significantly inhibited the surge. The muscarinic cholinergic agonist, arecoline
      (Arec), when administered at 12.00 h, delayed the surge, while the repeated
      administration of Arec completely blocked the surge. Atropine (Atro) (10 m/kg at
      12.00 h and 5 mg/kg every 2 h thereafter) did not have any effect on the Prl
      surge, but when administered simultaneously with Arec, prevented the inhibitory
      effect of Arec on Prl release. The data suggested that the adrenergic and
      serotonergic systems have a positive input in the occurrence and magnitude of the
      surge and that the cholinergic system does not appear to have a physiologic role
      in tonically inhibiting Prl release, but may function under certain special
      conditions.

PMID- 1028956
TI  - Increase in 3H-estradiol binding in brain and pituitary with time after
      gonadectomy in adult male and female rats.

PMID- 1028957
TI  - Influence of dopaminergic agonists and antagonists on serum prolactin
      concentrations in the rat.
AB  - Inhibitors of dopaminergic neurotransmission, such as reserpine (RES), given
      alone or combined with alpha-methyl-p-tyrosine (alpha-MpT)or Ro 4-4602, as well
      as haloperidol (HAL) and sulpiride (SUL), induced highly elevated serum prolactin
      (Prl) concentrations in intact rats. In contrast, the dopaminergic agonists
      apomorphine (APO), lisuride hydrogen meleate (LHM), D-amphetamine (AMPH),
      piribedil and L-dopa greatly lowered the high serum Prl concentrations in female
      rats induced by i.p. pretreatment with 2 mg/kg RES. Additional inhibition of
      catecholamine synthesis in RES-treated animals by alpha-MpT abolished the effect
      of AMPH, which indicates that the effect of this compound is mediated through
      newly synthesized dopamine (DA), while the effect of APO and LHM remained
      unchanged. Inhibition of dopa decarboxylation by Ro 4-4602 within the whole body
      abolished the effect of L-dopa, while lower dosages of Ro 4-4602, which do not
      penetrate the blood-brain barrier, had less effect. The noradrenergic receptor
      stimulating agent clonidine (CLON) had no Prl-lowering effect in RES-treated
      female rats. In hypophysectomized rats bearing 4 pituitaries transplanted under
      the kidney capsule, APO and LSM still lowered serum Prl concentrations, while
      AMPH had no effect; SUL produced a strong increase. These results support the
      hypothesis that DA has a dominant role as an inhibitor of Prl secretion by acting
      itself as the Prl inhibiting factor (PIF) on dopaminergic receptors located
      within the pituitary.

PMID- 1028958
TI  - Conference of Deans and Principals of Medical Colleges in India, held on April 23
      24, 1976 at New Delhi: Summary report of the proceedings.

PMID- 1028959
TI  - Conference of Deans and Principals of Medical Colleges in India, held on April 23
      24, 1976 at New Delhi: Post-concluding session: medical research in medical
      colleges.

PMID- 1028960
TI  - Health services of Sri Lanka.

PMID- 1028961
TI  - Review of NMEP in India.

PMID- 1028962
TI  - A study of managerial style of the district family planning administrators.

PMID- 1028964
TI  - Conference of Deans and Principals of Medical Colleges in India, held on April 23
      24, 1976 at New Delhi: Introduction.

PMID- 1028963
TI  - National population policy.

PMID- 1028965
TI  - Job characteristic relationships: individual and structural moderators.

PMID- 1028966
TI  - [Dynamic characteristics of a thermoregulator with a self-maintained circuit for
      medical thermostatic units].

PMID- 1028967
TI  - [Express control of the magnetization of magnetic conductors in the industrial
      production of electrodynamic transformers].

PMID- 1028968
TI  - [Automation of laboratory research].

PMID- 1028969
TI  - [Attempt at creating the 1st Soviet AB-1 biochemical autoanalyser].

PMID- 1028970
TI  - [Method of determining the metrological parameters of biochemical autoanalysers
      and their experimental evaluation].

PMID- 1028971
TI  - [Concept of creating an automated biochemical laboratory].

PMID- 1028972
TI  - [Effect of the conditions of delivering and storing biospecimens on the
      biochemical blood index values].

PMID- 1028973
TI  - [Possible sources of errors and methods to control the results obtained in an
      automated biochemical laboratory].

PMID- 1028974
TI  - [Prospects for automating the basic groups of physiochemical laboratory research
      methods].

PMID- 1028975
TI  - [Photometer with a pulsed source of radiation for biochemical research].

PMID- 1028976
TI  - [Device for the determination of the degree of blood hemoglobin saturation with
      oxygen in an artificial circulation apparatus system].

PMID- 1028977
TI  - [Setup for the express registration of oxyhemoglobin dissociation curves].

PMID- 1028978
TI  - [Methods of verification of photometric devices using sector disks].

PMID- 1028979
TI  - [Medical laboratory technology in the 10th Five-Year Plan].

PMID- 1028980
TI  - [Measurement of the error of a spectrophotometer used for calibrating medical
      laboratory devices].

PMID- 1028981
TI  - [Study of the parameters of an impulse lamp-photomultiplier circuit used in
      devices for medical laboratory research].

PMID- 1028982
TI  - [Use in the clinic of the TEM-1 thromboelastometer].

PMID- 1028983
TI  - [Automatic registration of thrombocyte aggregation].

PMID- 1028984
TI  - [Use of microquantities of capillary blood for registration of the
      thromboelastogram].

PMID- 1028985
TI  - [Complex assessment of the polarographic parameters of the blood serum of
      oncological patients].

PMID- 1028986
TI  - [Infrared spectrophotometry for measuring small amounts of protein in the air].

PMID- 1028987
TI  - [POV-1 device for taking air samples and its use in air research].

PMID- 1028988
TI  - [Technical equipment for the conductometric method of identifying
      microorganisms].

PMID- 1028989
TI  - [Levels of equal perception of vibration].

PMID- 1028990
TI  - [Indicatrix of light scattering on a single erythrocyte].

PMID- 1028991
TI  - [Accuracy of computing the indicatrix of light scattering on an erythrocyte in a
      first order Born approximation].

PMID- 1028992
TI  - [Calculation of 2-position thermoregulatores for medical laboratory devices].

PMID- 1028993
TI  - [Dynamic characteristics of a microcolorimeter with combined heating and sensing
      elements].

PMID- 1028995
TI  - The American Dental Association stance toward expanded duty dental auxiliaries.

PMID- 1028994
TI  - A health policy, anyone? or What this country needs is a market health risk
      equity plan!

PMID- 1028996
TI  - Progressive facial hemiatrophy (Parry-Romberg syndrome).
AB  - Three cases of progressive facial hemiatrophy are presented. In all three cases
      there is evidence of localised scleroderma or morphea in association with the
      facial hemiatrophy. This would seem to support the contention that the two
      disorders are closely related. In two cases, ocular complications are prominent
      and in one Raynaud's phenomena provide clear asymmetrical dilatation of the
      lateral ventricle suggest that there may be a central rather than a peripheral
      cause for the sympathetic overactivity.

PMID- 1028997
TI  - Electrophysiological and pathological studies in spinocerebellar degenerations.
AB  - Electrophysiological and pathological studies have been performed on the
      peripheral nerves of patients with spinocerebellar degenerations. In Friedreich's
      ataxia there is impairment of sensory conduction and mild slowing of motor
      conduction which may be correlated with loss of large diameter fibres in the
      sural nerve. The abnormalities in Friedreich's ataxia are present early, in the
      first decade. In hereditary spastic paraparesis the nerve conduction studies and
      sural nerve biopsy are normal. In the other spinocerebellar degeneration and a
      mild loss of myelinated fibres in the sural nerve. However the abnormalities
      differ from those seen in Friedreich's ataxia.

PMID- 1028998
TI  - The use of clonazepam in the treatment of tic douloureux (a preliminary report).
AB  - Results are reported of a preliminary trial with clonazepam in 19 patients with
      trigeminal neuralgia refractory to carbamazepine treatment. In this series of
      patients, 13 (68.4%) showed excellent or good improvement. No serious side
      effects were seen. The pharmacology and mechanism of action of clonazepam are
      discussed. It is suggested that patients with trigeminal neuralgia, who do not
      respond to carbamazepine, should be given clonazepam before surgery is
      considered.

PMID- 1028999
TI  - Serial nerve conduction studies in patients with maturity onset diabetes
      mellitus.
AB  - Serial study of peripheral nerve conduction in 18 patients with recently
      diagnosed maturity onset diabetes mellitus during a period of treatment of
      hyperglycaemia for 21/2 years showed improvement in motor conduction progressive
      increase in mixed nerve conduction velocity, but at the same time progressive
      fall of amplitude of sensory nerve action potentials. It is argued that two
      independent metabolic processes may underlie peripheral nerve dysfunction in
      these patients, only one of which is benefically affected by control of
      hyperglycaemia.

PMID- 1029000
TI  - Performance changes during recovery from closed head unjury.

PMID- 1029001
TI  - The continual administration of neostigmine and the neuromuscular junction.
AB  - The effect of continual administration of neostigmine on the neuromuscular
      junction of the rat diaphragm was examined by determining the number of quanta of
      acetylcholine released by each nerve impulse, the effect of differing repetition
      rats on quantal release and the amplitude and frequency of miniature end-plate
      potentials. The number of quanta of acetylcholine released at a nerve impulse
      repetition rate of 1/sec was reduced to 51% of normal in treated animals. The
      reduction was greater at faster repetition rates. The amplitude of miniature end
      plate potentials was reduced to 75% of normal. This reduction appears to be due
      to blocking of receptor sites rather than the reduction in the amount of
      acetylcholine in each quantum. The frequency of spontaneous miniature end-plate
      potentials was reduced in treated animals.

PMID- 1029002
TI  - Evoked potential studies in neurological disorders.
AB  - Techniques for recording and analysing visual and somatosensory evoked reponses
      using an on-line PDP 11/40 computer have been developed and applied to a group of
      subjects with established or suspected multiple sclerosis as well as to patients
      with a variety of other lesions of the visual pathways, myoclonic epilepsy and
      functional neurological deficits. The most consistent responses were obtained
      using the pattern reversal visual evoked response and the spinal somatosensory
      evoked response, abnormal responses being found with both techniques in a
      significant number of patients with suspected demyelinating disease even in the
      absence of symptoms or signs referable to the visual or somatosensory pathways.
      The complementary role of these techniques in the detection of sub-clinical
      abnormalities of conduction in sensory pathways in patients with suspected MS is
      emphasized.

PMID- 1029003
TI  - Computerized axial tomography for intracranial diagnosis.

PMID- 1029004
TI  - Hereditary hypertrophic neuropathy in the Trembler mouse: electrophysiological
      studies.

PMID- 1029005
TI  - Computerized axial tomography findings in a group of patients with migrainous
      headaches.
AB  - Computerized axial tomography of the cranium has been carried out in 46 patients
      referred because recurring migrainous headaches. Increasing frequency or severity
      of headaches or a change in headache pattern were the usual reasons for referral.
      Abnormalities were found in 37 cases and fell into 4 categories. The most
      frequent (21 cases) consisted of a mild degree of oedema in the white matter of
      one or both cerebral hemispheres. This was usually bi-frontal (15 patients) but
      was more extensive in 2 patients. Varying degrees of cerebral atrophy, as
      determined by widening of the Sylvian, brain-stem and interhemispheric cisterns,
      and/or widening of the third and lateral ventricles as compared to a group of
      normal scans, was found in 8 cases. Areas of occipital infarction were found in 4
      patients with permanent visual field defects. Unexpected small areas of
      infarction were found in the temporal lobe in 2 other cases. Cerebral tumours
      were found in 2 cases. The significance of these findings is discussed, as well
      as the possible role of migrainous vaso-spasm with consequent changes in cerebral
      blood flow in the pathogenesis of oedema and atrophy in migraine subjects.

PMID- 1029006
TI  - Three cases of post traumatic vascular headache treated by surgery.
AB  - Three cases are reported of vascular headache following trauma and which failed
      to respond adequately to standard therapy for migraine. In each case the effect
      of ligation of the arteries involved has been dramatic, with complete and lasting
      relief in two cases.

PMID- 1029007
TI  - A unique case of derangement of vitamin B12 metabolism.
AB  - The case is described of a child, age 6 1/2 years, with retarded mental
      development, mild neurological signs and abnormal metabolism of sulphur
      containing amino acids and methylmalonate, due to an inborn error in the
      formation of vitamin B12 coenzymes. The patient was treated for almost three
      years with hydroxycobalamin, folic acid, pyridoxine and choline. Though physical
      growth was normal, she continued to demonstrate a moderate degree of mental
      retardation. A brother of the patient died at the age of 5 years, probably of a
      similar, but undiagnosed, disorder. As far as we are aware there are only four
      other reported cases similar to the case described here. Two of these patients
      died and in other other two the defect was so mild that no treatment was
      necessary and who, in fact, showed appreciable improvement during the follow-up
      period, which to date amounts to 3 years and 3 months. For reasons detailed in
      the discussion, it is suggested that the diagnosis of homocystinuria is not
      complete until studies of folate and vitamin B12 metabolism are undertaken at the
      same time, so as to identify the metabolic defect(s) responsible for the
      condition.

PMID- 1029008
TI  - Epilepsy and driving.
AB  - 205 actual and potential drivers suffering from epilepsy were examined over a
      period of nine years in Tasmania under a State scheme whereby all such persons
      are referred to one neurologist. In Tasmania 0.3% of all road traffic accidents
      were due to epilepsy. 16% of the total who had had an accident had failed to
      disclose their disability and another 10% who were non-accident cases had
      similarly concealed their epilepsy. Only about 28% of the expected number (per
      year) of new cases of epilepsy in drivers disclose their complaint. Alcohol was a
      significant association with epilepsy in just over 8%. Medication should continue
      for at least three consecutive fit-free years and preferable five years. Only two
      out of 170 drivers approved to drive had a subsequent accident due to epilepsy.

PMID- 1029009
TI  - Pattern visual evoked potentials in the diagnosis of multiple sclerosis and other
      disorders.
AB  - The diagnostic value of pattern visual evoked potentials has been assessed in a
      pilot study of 22 patients with proven or suspected multiple sclerosis. Of 7
      patients satisfying McAlpin's criteria for diagnosing definite multiple
      sclerosis, 6 had delayed potentials. Four of 5 patients with probable multiple
      sclerosis, and 5 of 10 patients with possible multiple sclerosis, had delayed
      potentials. Ten patients with delayed potentials had no history of optic
      neuritis. Changes in the evoked potential with other neurological conditions that
      may affect the visual system are also described.

PMID- 1029010
TI  - Some aspects of tuberculous meningitis in Surabaya.
AB  - Eighty tuberculous meningitis patients who were seen in the neurological clinics
      in Surabaya between the January 1971 and January 1975 were asked to cooperate in
      a double blind clinical trial. One group was given isoniazid, streptomycin and p
      aminosalicylic acid, the other group was given isioniazid, rifampicin, ethambutol
      and a protease. The outcome after the treatment with isoniazid, rifampicin and
      ethambutol was significantly better than that with isoniazed, streptomycin and p
      aminosalicylic acid. The clinical and laboratory symptoms and signs are reviewed
      in detail.

PMID- 1029011
TI  - An animal model for the study of drugs in the central nervous system.
AB  - An animal model which allowed repetitive sampling of CSF is described. It had a
      wide potential application and was used to study the passage of clonazepam into
      the central nervous system. A highly sensitive clonazepam assay is described
      which allow measurement of CSF and free serum concentrations as low as 0.5 ng/ml.
      Clonazepam passed rapidly into the central nervous system and its CSF
      concentration closely approximated to the concentration of unbound clonazepam in
      serum. Protein binding of clonzaepam in the sheep was 90-95%.

PMID- 1029012
TI  - The effects of phenobarbitone dose on plasma phenobarbitone levels in epileptic
      patients.
AB  - The relation between plasma phenobarbitone level and phenobarbitone dose was
      studied in 121 patients. The relation changed with age, the dosage requirement
      (on a day weight basis) tending to fall as patients grew older. Males under 5
      years had a higher dosage requirement than females of the same age, but otherwise
      sex did not affect the relationship, nor did the concurrent intake of the
      anticonvulsants phenytoin, carbamazepine or sulthiame. In the individual, plasma
      phenobarbitone levels tended to increase out of proportion of dosage increases.
      These findings can provide a basis for prescribing appropriate phenobarbitone
      doses in epileptics.

PMID- 1029013
TI  - On the visual disturbances associated with massive basal aneurysms.
AB  - When massive basal aneurysms compromise the anterior visual pathways the
      resulting disturbances of vision are diverse and a firm clinical diagnosis is
      difficult. Because of the rarity of the condition, a critical analysis of the
      visual defects was made in five personally studied patients with large anterior
      basal aneurysms in an effort to clarify the clinical features of the disorder.
      These observations were related to those reported in larger series of patients by
      Jefferson and Bull. This study gives support to the opinion that the commonest
      visual defect seen with massive basal aneurysms is impairment of visual acuity,
      followed next in frequency by bitemporal hemianopia, and then by junction
      scotoma.

PMID- 1029014
TI  - de Broglie waves in amoeboid motility.
AB  - The de Broglie wave equation has been applied to the study of amoeboid motility.
      This leads to precise predictions of wavelengths displayed by the cellular
      membrane during motility. Motile amoeba are compared to non-biological systems
      showing de Broglie wave behavior, and three simple experiments are suggested.

PMID- 1029015
TI  - Chemiluminescence of cigarette smoke.
AB  - Chemiluminescence from cigarette smoke (aerosol) and smoke "extracts"
      (suspensoids) are described. The emissons from aqueous and organic suspensoids
      persist for hours, are proportional to oxygen solubilities, possess energy of at
      least 1.8 electron volts, and display characteristics which suggest that the
      emissions may be partially sensitized by singlet oxygen.

PMID- 1029016
TI  - Normalization of the diabetic syndrome in hereditary diabetic mice by PGBx, a
      polymeric derivative of prostaglandin B.

PMID- 1029017
TI  - Bone lipids of marine fishes.
AB  - Assessment of candidates for investigation of bone lipid metabolism yielded the
      following findings. (1) A tropical marine butterflyfish, Chaetodon ornatissimus,
      had oil-filled bones (66-80% lipid, percent dry weight) hence may be a suitable
      condidate. (2) The tropical marine fishes Exallias brevis, Pomacentrus jenkensi,
      and Chromus agilis, and a Canadian fish Sebastes ruberrimus, had intermediate
      quantities of oil in their bones (12-49% lipid). (3) In all the foregoing species
      the major bone lipid was triglyceride, usually more abundant in skull than spine.
      Sterol and phospholipid were also present. (4) The major fatty acids of the
      triglycerides (and phospholipids) were 16:0, 18:0, 18:1, and C20, C22 acids.
      Those acids were dominated by 20:4, 20:5, 22:5, and 22:6. (5) There was more
      total unsaturation in the bone lipids of S. ruberrimus (from 10 degrees C water;
      67-72% unsaturation) compared to the tropical fish (from 25 degrees C water; 32
      67% unsaturation) with the exception of E. brevis. (6) One of the tropical
      species (Arothron meleagris) and a Canadian Chimaeran (Hydrolagus colliei)
      contained only 1-3% lipid in their bones.

PMID- 1029018
TI  - Models for biological ion exchangers. II. Solvent selectivity in DMSO-water-Dowex
      50W.
AB  - Dimethylsulfoxide-water-Dowex 50W-X8 systems are characterized by measurements of
      solvent selectively and proton magnetic resonance spectra. The H+-, Li+-, NH4+-,
      NHe4+-, NBu4+-, Mg2+-, Zn2+-, and La3+- forms are studied over a wide range of
      binary-solvent mole fractions. The relative selectivities for water by the ion
      exchanger, based on an integrated Kipling parameter, are Zn2+-form (reference) -
      1.00, Mg2+ --0.43, La3+ --0.38, Li+ +0.17, NMe4+ 0.20, NH4+ 0.31, NBU4+ 0.33, and
      H+ 0.68, the polyvalent counterions preferring DMSO. All of the ionic forms
      except the NH4+-form exhibit over much of the mole fraction range separations
      between the external water and the internal water peaks exceeding 50 Hz, the
      magnitude of the separation varying with the counter-ion. Comparison of results
      is facilitated by maintaining a constant ratio between the total number of moles
      of solvent and the number of equivalents of ions exchanger.

PMID- 1029019
TI  - Studies on a patient with iminopeptiduria. I. Identification of urinary
      iminopeptides.
AB  - A patient suffering from recurrent ulcers on the legs was found to excrete large
      amounts of iminodipeptides in the urine. Among the iminodipeptides excreted, Glu
      Hyp, Asp-Pro, Glu-Pro, Leu-Hyp, Gly-Pro, Thr-Pro, Ser-Pro, Ala-Pro, Val-Pro, Ile
      Pro, Leu-Pro, and Phe-Pro were identified and their quantities estimated. Some of
      the iminopeptides had to be synthesized for purposes of identification.

PMID- 1029020
TI  - The role of product release in enzyme catalysis.
AB  - Conceptual definitions of maximal velocity and the Michaelis constant are
      provided that do not involve the assumption of any rate-determining step. The
      experimental basis of those definitions is a combination of pre-steady state and
      steady state kinetic observations.

PMID- 1029021
TI  - Experimental evidence for high-temperature organic fractional superconduction in
      cholates.
AB  - Experimental data are presented indicating that six organic compounds (homologous
      cholates) possess properties associated with high-temperature superconductivity.
      From magnetic and electrical measurements it is deduced that behavior resembling
      superconductivity occurs below characteristic transition temperatures in small
      domains included in the insulating bulk of the sample material, which is
      therefore designated a fractional o Type III superconductor. The six cholates
      exhibit this superconductivity below transition temperatures ranging from
      approximately 7.5 degrees K for sodium dioxycholate to 277 degrees K for sodium
      cholanate. It has been further established that the diamagnetic shifts with
      temperature cannot be attributed to ferrielectric, ferroelectric, or capacitive
      effects. Below the transition temperatures the cholates behave like perfect
      diamagnets, susceptible to forceful repulsion by a moderate magnetic field.
      Observed in a sensitive susceptometer, magnetic flux trapped in the material gave
      rise to a 3% remnant magnetic moment. Studied in particular detail were sodium
      cholate, sodium deoxycholate, and lithocholic acid, which showed transition
      temperatures of 30 degrees K, 60 degrees K, and 130 degrees K respectively. The
      hydrophobic property of the closed four-ring structure (R-group) common to the
      cholates, along with the hydrophilic property of the carboxylate group (S-group),
      are responsible for domain formation. Because of those properties, clustering of
      the S-groups occurs when traces of water are introduced into the material. When
      followed by slow desiccation, the clusters form the micelles constituting the
      superconducting domains.

PMID- 1029022
TI  - Protection against toxic effects of formaldehyde in vitro, and of methanol or
      formaldehyde in vivo, by subsequent administration of SH reagents.
AB  - Rapid and progressive inactivation in vitro of both alcohol dehydrogenase and
      aldehyde dehydrogenase by low concentrations of acetaldehyde or formaldehyde is
      illustrated. This inactivation can be prevented or reversed by glutathione or
      other SH reagents. Those effects led to investigations in vivo. Rats and mice
      were injected with concentrations that would result in death in approximately 10
      h (methanol) and approximately 4 h (formaldehyde). When 2,3-dimercaptopropanol
      (BAL), cysteine, or mercaptoethanol was injected (10 min to 3 h) after
      administration of methanol or formaldehyde, approximately 70% of the animals
      survived indefinitely; the remaining 30% showed substantial increase in survival
      time. The findings indicate the possibility of using reagents such as BAL for
      human therapy and suggest that the toxicity of methanol and formaldehyde is due
      in part to effects other than acidosis.

PMID- 1029023
TI  - Chromatin hyperchromicity in chickens with muscular dystrophy.

PMID- 1029024
TI  - The policy implications of predictive decision-making: "likelihood" and
      "dangerousness" in civil commitment proceedings.

PMID- 1029025
TI  - [Management and complications in the treatment of esophageal atresia].

PMID- 1029026
TI  - [Pathology of the diaphragm in children].

PMID- 1029027
TI  - [Acute appendicitis in children].

PMID- 1029028
TI  - [Evolution of appendiceal peritonitis].

PMID- 1029029
TI  - [Cholecystitis and cholelithiasis in children].

PMID- 1029030
TI  - [Elbow shaped or otherwise malformed gallbladder].

PMID- 1029031
TI  - [Acute pancreatitis in children].

PMID- 1029032
TI  - [Basis of the histochemical diagnosis of Hirschprung's disease].

PMID- 1029033
TI  - [Hyadatidosis of the renal fossa].

PMID- 1029034
TI  - [Neuroleptoanalgesia in pediatric surgery].

PMID- 1029035
TI  - [Ovarian cyst in the newborn].

PMID- 1029036
TI  - [Experience of a post-graduate pediatric surgeon and orthopedist in his 1st year
      in a province].

PMID- 1029037
TI  - Independent health insurance plans in 1974.

PMID- 1029038
TI  - When crises get the upper hand.

PMID- 1029039
TI  - Home care for pediatric respiratory patients.

PMID- 1029040
TI  - Departmental design.

PMID- 1029041
TI  - Use of a programmable calculator in blood-gas and acid-base determinations.

PMID- 1029042
TI  - Credentialing controversy.

PMID- 1029043
TI  - Involvement versus detachment.

PMID- 1029044
TI  - Credentialing controversy.

PMID- 1029045
TI  - Credentialing controversy.

PMID- 1029046
TI  - Evolution of improved capabilities in spirometric test equipment.

PMID- 1029047
TI  - Shared services in education for the small community hospital. Part I.

PMID- 1029048
TI  - A managerial view of the four-day week.

PMID- 1029049
TI  - Treating the suicidal patient: a psychologist's view. Part II.

PMID- 1029050
TI  - Parent participation in the care of high-risk infants.

PMID- 1029051
TI  - The pharmacokinetics of oxygen administration.

PMID- 1029052
TI  - Epidemic haemorrhagic conjunctivitis. A study of neutralising antibodies.

PMID- 1029053
TI  - Corneal changes in endemic trachoma.

PMID- 1029054
TI  - Eye-health care (clearing-up terminology).

PMID- 1029055
TI  - Trachoma - a public health problem.

PMID- 1029056
TI  - Trachoma - a public health problem.

PMID- 1029057
TI  - Th reaction of the trachomatous eye to intraocular surgery.

PMID- 1029058
TI  - [Epidemiological contribution to the etiology of chronic bronchitis. I. Study on
      the reproducibility of the answers to the questionnaires on chronic bronchitis].

PMID- 1029059
TI  - [Epidemiological contribution to the etiology of chronic bronchitis. II. Choice
      of a pulmonary function test suited for epidemiologic studies in large groups].

PMID- 1029060
TI  - [Epidemiological contribution to the etiology of chronic bronchitis. III.
      Standardization of methods suitable for the study of bronchial hyperreactivity
      and allergy in epidemiology].

PMID- 1029061
TI  - [Epidemiological contribution to the etiology of chronic bronchitis. V. Results
      of an epidemiological investigation among large groups of miners and
      metallurgists at work, concerning their smoking habits and the general air
      pollution].

PMID- 1029062
TI  - [The struggle against dust in the Belgian coal mines. Situation at the beginning
      of 1976].
AB  - The present communication gives a general view of the methods of dust control in
      the Belgian coal mines at the beginning of 1976. The statistical data received
      from the mines are presented in tabular form. The length and the output of coal
      faces treated by the classical methods of pre-spraying of the wall, wet cutting,
      water infusion and wet pneumatic picks, are given separately; in some cases two
      or more of these technics are used together on the same coal face. The number of
      stone drivages in which different methods of dust control are used, is also
      given.

PMID- 1029064
TI  - Morphometric study of the diploid karyotype of the crested newt, Triturus
      cristatus carnifex (Laur.)

PMID- 1029063
TI  - Effect of some environmental pollutants on the behaviour of motility of Dugesia
      gonocephala S.L. Note I.

PMID- 1029065
TI  - Identification and isolation of a thrombocytopoietic thymic factor.

PMID- 1029066
TI  - Action of fluorescein isothiocyanate on plasmatic erythropoietin and on the renal
      and splenic erythro-stimulant factors in the rabbit.

PMID- 1029067
TI  - Mesencephalic degeneration following ablation of a telencephalic hemisphere in
      Coturnix c. japonica.

PMID- 1029068
TI  - The sexual reproduction of Tetilla sp. (Tetractinellida - Porifera).

PMID- 1029069
TI  - Electrophoretic pattern of the haemolyzate in specimens of Lampetra planeri
      (Bloch), captured in Abruzzo, in relation to the developmental cycle.

PMID- 1029070
TI  - [Smoking prohibition at the working site. Priority No. 1 of industrial medicine
      and industrial legislation].

PMID- 1029071
TI  - [Psychophysical aspects of passive smoking. Contribution on the labor union
      demand for "humanization of the working site"].

PMID- 1029072
TI  - [Pleasure experience and pleasure addiction of the smoker as a sociological and
      legal environmental-protection problem. Contribution to basic research on the
      necessity, legality and limits of smoking prohibition at the working site].

PMID- 1029073
TI  - Human psychophysical analysis of receptive field-like properties. I. A new
      transient-like visual response using a moving windmill (Werblin-type) target.
AB  - A human transient-like visual response has been revealed psychophysically with a
      rotating windmill target, similar to that used by Werblin in his recent studies
      of the retina of Necturus. The windmill pattern evoked complex perceptual
      phenomena (important in and of themselves) which were minimized by using a high
      luminance for the "criterion" flashing test field (relative to its increment
      threshold), and by moving the four-vaned windmill pattern at a rate of two
      complete revolutions per second. The transient response, herein defined as the
      difference in threshold between the stationary and moving windmill conditions,
      was greatest when the windmill vanes fell completely within the sensitization
      (inhibition-like) portion of the Westheimer function determined at the same
      retinal locus. The test has been developed so that it may be readily adapted to
      available clinical equipment for future diagnostic purposes .

PMID- 1029074
TI  - Areal and temporal summation in the thermal reaction time.
AB  - It has previously been shown that the reaction time (RT) to radiant heat measures
      spatial summation of warmth, because the RT decreases with increases in both the
      areal extent and the intensity (flux density) of the heat. The previous studies
      of RT let the response terminate the stimulus exposure and thus introduced a
      confounding between stimulus duration and intensity, since the weaker the
      stimulus is, the longer it is presented. The present study shows the RT reflects
      spatial summation even with a fixed, brief stimulus duration. The precise rules
      for trading area and intensity that are obtained with fixed-duration pulses
      differ from those obtained with response-terminated ones, but both sets of
      functions are consistent with each other and with the results of magnitude
      estimation if it is assumed that the sensory effect of the heat sums over the
      stimulus duration, that is, that the RT reflects temporal as well as spatial
      summation. Two further experiments provide direct evidence for temporal
      summation.

PMID- 1029075
TI  - Some effects of aphasic lesions on order perception.
AB  - Twenty-four aphasic, nine brain-damaged, and eight non-brain-damaged patients
      were tested for their ability to associate odors with visual targets. The results
      of the experiment show that lesions producing aphasia interfere with the ability
      to match an odor to a directly corresponding visual target. As aphasics with
      anterior and posterior lesions performed at similar levels in this task, it was
      not possible to conclude that the observed deficits were specifically related to
      temporal lobe functions. The severity of the deficit was greater for more
      massively lesioned aphasics. The exact nature of the deficit was not clear, but
      review of the literature and differential results obtained for the two
      experimental tasks suggest that aphasic lesions may interefere with odor
      identification.

PMID- 1029076
TI  - Attenuation of vibrotactile spatial summation.
AB  - Masked and quiet thresholds at several frequencies of vibratory stimuli were
      measured as a function of contactor area. The test site was the left index 
      finger; the masking site was the left little finger. The quiet threshold data
      were consistent with previous investigations: Low-frequency stimuli showed no
      spatial summation, whereas high-frequency stimuli did. In the presence of a
      masker, spatial summation was reduced or eliminated for high-frequency stimuli,
      i.e., the masked threshold was, under some conditions, independent of contactor
      area. Low-frequency stimuli continued to show no spatial summation in the
      presence of a masker. The attenuation of spatial summation appears to be a direct
      function of the intensity of the masking stimulus. Additional measurements with
      the left thenar eminence as the test site showed that spatial summation could be
      attenuated by a masker placed on a contralateral body site. The implications of
      the results for quantifying the effectiveness of a masking stimulus, for the
      duplex mechanoreceptor hypothesis, and for the nature of spatial summation on the
      skin are discussed.

PMID- 1029077
TI  - Olfaction and the common chemical sense: some psychophysical contrasts.
AB  - Three experiments explored the olfactory and the common chemical attributes of
      sensations produced by various concentrations of n-butyl alcohol. These two
      attributes combine in an almost-linear fashion to produce the overall perceived
      intensity of the stimulus. Common chemical intensity makes only a small
      contribution to overall magnitude at low concentrations, but its proportional
      contribution increases with concentration. In like manner, speed of response
      (i.e., reciprocal of reaction time) to the common chemical attribute increases
      more rapidly than that to odor. Nevertheless, odor always makes its appearance
      sooner than the common chemical attribute, even when the two attributes are
      matched in perceived magnitude. Repeated inhalations cause odor intensity to
      decrease slightly but cause common chemical intensity to increase dramatically.
      The results obtained from the normal subjects studied here agree with those
      obtained from subjects with unilateral destruction of the trigeminal nerve.

PMID- 1029078
TI  - Evidence in support of the duplex theory of mechanoreception.
AB  - Psychophysical thresholds were measured as the frequency, size and duration of
      vibration on the thenar eminence was varied. The results supported the theory
      that there are two functionally distinct receptor systems in the skin for the
      perception of mechanical disturbances. Spatial and temporal summation were found
      for the detection of high- but not low-frequency stimuli. Furthermore, magnitude
      estimation data revealed that temporal summation occurs for the perception of
      high-frequency stimuli presented over a wide range of suprathershold values. On
      the other hand, temporal summation was absent for low frequency stimuli that were
      presented at 5, 10, 15, and 20 db above threshold.

PMID- 1029079
TI  - The saltatory effect in vision.
AB  - Events in vision triggered by brief flashes in train prove to be strictly
      analogous to those generated in the skin by a succession of taps. A requisite
      condition for their appearance in vision is projection of the flashes into the
      peripheral retinal field. Experiments are described that establish the general
      relation between extent of saltatory leaping and degree of retinal eccentricity
      and between leaping and retinal subtense of stimulus patches. Additionally, a
      curious "dip" phenomenon and several qualitative experiments in which color has
      been used to "tag" the saltatory image are reported.

PMID- 1029080
TI  - Interaction of spatial and temporal summation in the warmth sense.
AB  - Two experiments explored the interaction of  spatial and temporal summation in
      the perception of radiant heat. The first experiment showed that the absolute
      threshold for detecting two brief (0.1 sec) pulses of heat, one presented to each
      side of the forehead, is lower than the threshold for detecting a single pulse,
      even when the two pulses are separated in time by as muchas 0l75 sec. The second
      experiment showed that a single, 4-sec pulse of heat presented to one side of the
      forehead feels no warmer than two successive, 2-sec pulses, one to each side.
      Spatial and temporal summation appear to take place at least partly in the
      central nervous system.

PMID- 1029081
TI  - Critical band in auditory lateralization.
AB  - A new and powerful procedure for determining frequency analysis in the auditory
      system, as evidence by the critical band, is described. The onset time
      difference, delta T, needed to lateralize 30-msec tone bursts toward the leading
      ear was measured as a function of the frequency difference, delta F, between the
      brust in one ear and the burst in the other ear. When delta F was less than the
      critical band, threshold delta T was constant at 100 mu sec or less, depending on
      center frequency; beyond the critical band, delta T increased with delta F. These
      dichotically measured critical bandwidths increased from 110 Hz at a center
      frequency of 500 Hz to 1100 Hz at a center frequency of 6000 Hz. They were
      unaffected by varying signal level from 25 to 80 dB or signal duration from 10 to
      300 msec. The sam e critical-band values have been measured with monaural stimuli
      in loudness summation, maskin, detection, phase perception, consonance, and so
      forth.

PMID- 1029082
TI  - Effect of double ipsilateral stimulation on vibrotactile sensation magnitude.
AB  - The phenomena of enhancement and suppression of vibrotactile subjective magnitude
      were investigated using a matching procedure. Results support earlier reports for
      audition and vibrotaction suggesting that enhancement is a fundamental sensory
      process. The time course is described for suppression of stimuli delivered to
      several different to several different pats of the body. The results are
      consistent with earlier studies of vibrotactile masking at threshold levels.

PMID- 1029083
TI  - Vibrotactile temporal summation: effect of frequency.
AB  - Temporal summation of vibrotactile stimuli was measured at four frequencies (25,
      40, 80, and 160 Hz) using a large contactor. Stimulation at 160 Hz gave temporal
      summation comparable in amount to that reported in previous studies. Stimulation
      at 25, 40, and 80 Hz gave less summation. The presence of summation at low
      frequencies is unexpected in view of existing data obtained with small
      contactors' those data indicate that the afferent system primarily sensitive to
      low frequencies may not summate stimulus energy over time. The present data
      suggest either that the low-frequency afferents do summate energy over time or
      that, under some conditions, the perception of low-frequency signals presented
      through a large contactor may be mediated by more than one afferent system.

PMID- 1029084
TI  - Temporal properties of the human taste system.
AB  - An attempt to apply linear systems methods to the temporal properties of the
      human taste system is described. The percentage modulation in concentration
      required to detect a fluctuation in intensity was measured as a function of
      frequency of modulation. Both a sine-wave and a square-wave input were used. The
      sensitivity of the taste system at its maximum, and also at the low frequencies,
      was greater than expected from previous work based on classical methodology. The
      sensitivity of the taste system at its maximum, and also at the low frequencies,
      was greater then expected from previous work base on classical methodology. The
      sensitivity of the taste system to the various qualities was, in decreasing
      order, salty, sweet, sour, and bitter. The taste system in insensitive to
      frequencies above about 5 Hz. Except for bitter, representatives of the various
      taste qualities yielded similar functions within qualities.

PMID- 1029085
TI  - Satiation in cutaneous saltation.
AB  - The extent of cutaneous saltation (the illusory displacement of a tap presented
      to one skin locus by another tap occurring close in time at another locus) was
      modified by a "preconditioning" stimulus presented prior to and at a site distant
      from the saltatory test pattern. The 10-sec vibratory preconditioning (PC)
      stimulus appears to be analogous to inspection figures that "satiate" the
      perceptual field in experiments on figural aftereffects, producing changes in the
      perceived size, position, or shape of subsequent stimuli. The direction of
      displacement of the saltatory phantom was always away from the locus of the prior
      PC stimulus, consistent with results observed in studies of visual and
      kinesthetic aftereffects. Th- amount of repulsion and the rate at which the
      saltatory phantom returned to its initial position depend on the intensity,
      locus, and number of PC stimuli. As with figural aftereffects, these results
      resist explanation by peripheral mechanisms such as adaptation.

PMID- 1029086
TI  - Recovery of excitability after gustatory adaptation: effects of stimulus
      intensity.
AB  - The excitability of the rat chorda tympani nerve following adaptation to NaCl was
      measured by observing the recovery of the transient portion of the integrated
      neural response. When a single concentration of NaCl was used as a test stimulus,
      recovery time was positively correlated with the concentration of the adapting
      solution, a relationship common to a number of other sensory systems. Adapting
      and testing with the same concentration of NaCl produced very little relationship
      between concentration and recovery time. It is suggested that the relativley
      extensive period of postexcitatory depression is due to a prolonged
      inaccessability of tast receptor sites that results in a reduction in the rate of
      stimulus-receptor interaction.

PMID- 1029087
TI  - Enophthalmos and diplopia in orbital floor fractures.

PMID- 1029088
TI  - Malignant melanoma of the nasal septum.

PMID- 1029089
TI  - Anesthesia for microlaryngoscopy.

PMID- 1029090
TI  - Problems in the clinical management of heavy smokers.

PMID- 1029092
TI  - Maxillary sinusitis.

PMID- 1029091
TI  - The spectacular lingual thyroid and midline anterior cervical ectopic thyroid.

PMID- 1029093
TI  - Rehabilitation of the adult deaf.

PMID- 1029094
TI  - Impedance audiometry: benefits, problems, and pitfalls.

PMID- 1029095
TI  - Retinal neovascularization.

PMID- 1029096
TI  - Biologic predestination: immunogenetic aspects of uveitis.

PMID- 1029097
TI  - Immediate postoperative complications of septoplasties and septorhinoplasties.

PMID- 1029098
TI  - Uveitis in rheumatologic diseases: clinical syndromes.

PMID- 1029099
TI  - Uveitis of immunologic origin: clinical syndromes.

PMID- 1029100
TI  - The changing pattern of the etiology of central bacterial corneal (hypopyon)
      ulcer.

PMID- 1029101
TI  - The physiology of the precorneal tear film.

PMID- 1029102
TI  - Some traumatic ossicular lesions.

PMID- 1029103
TI  - Immunosuppressive therapy of severe chronic uveitis.

PMID- 1029104
TI  - Congenital deafness, recurrent meningitis, and neural tube defects.

PMID- 1029105
TI  - Methods of ocular motor examination in neuro-opthalmology.

PMID- 1029106
TI  - Uveitis syndromes.

PMID- 1029107
TI  - Nasal glioma.

PMID- 1029108
TI  - Personal noise protection: a study of seven different devices.

PMID- 1029109
TI  - Computerized tomography of orbital disorders.

PMID- 1029110
TI  - Keratomycosis.

PMID- 1029111
TI  - The immunology and immunopathology of corneal infection.

PMID- 1029112
TI  - Congenital central corneal opacity: diagnosis and management.

PMID- 1029113
TI  - Acquired diffuse eipthelial erosion.

PMID- 1029114
TI  - Congenital laryngeal cyst in infants.

PMID- 1029115
TI  - Some instructive failures of stapedectomy.

PMID- 1029116
TI  - Acute epiglottitis: intubation versus tracheotomy.

PMID- 1029117
TI  - Parotid gland surgery.

PMID- 1029118
TI  - Inflammatory disease of the frontal sinus.

PMID- 1029119
TI  - [Electron-microscopic study of the nuclear membrane of the PKEV cells during
      mitosis. 1. The breakdown of the nuclear membrane (prophase, prometaphase,
      metaphase)].
AB  - An ultrastructural study on dividing PKEV cells provided a possibility to
      distinguish between certain stages of their desintegration. The changes preceding
      fragmentation of the nuclear envelope commence with desorganization of its
      structural components: vanishing of granular peripherial chromatin layer;
      appearance of the pores without central granules; formation of deep invaginations
      of the nuclear membranes. The desintegration of the nuclear envelope starts from
      the disapearance of many pores and the appearance of perforations almost of the
      same size. Simultaneously, the number of polysomes is reduced on the outer
      membrane of the nuclear envelope and in the cytoplasm. Specific features of the
      nuclear envelope being lost it becomes undistinguishable from the reticulum
      elements. On serial sections, no contacts were observed between chromosomes and
      membranous elements.

PMID- 1029120
TI  - [Ecologic-histophysiological analysis of the neurohypophysis-metaadenohypophysis
      complex of the sazan female before and after spawning].
AB  - Much neurosecretory material (4.4 +/- 0.1 units) is seen in the neurohypophysis
      of sazan females before spawning. A1, A2, and B type terminals contain numerous
      neurosecretory granules, in particular, elementary granules. Synaptic vesicles
      are not numerous. The amount of neurosecretory material decreases during and
      shortly after spawning down to 3.6 +/- 0.3 units. Neurosecretory terminals have
      less elementary granules. The number of granulated, disintegrating, residual
      granules and synaptic vesicles somewhat increases. It is hypothesized that mainly
      peptide neurohormones are discharged from A1 and A2 terminals in the common
      circulation, and that both peptide neurohormones and monoamines reach glandular
      cells of the metaadenohypophysis in sazan females during and immediately
      spawning. The role played by neurohormones and monoamines in controlling the
      function of both the metaadenohypophysis glandular cells and visceral organs
      involved in the general adaptive reactions of the fish organism is discussed.

PMID- 1029121
TI  - [Certain structural details of developing in vitro human embryonal brain explants
      studied with the aid of fluorescence and scanning electron microscopy].
AB  - The bundles growing away from the explants were mainly formed by neuroblast
      processes. It has been shown that the degree of differentiation of neuroblasts
      depends on "the age" of embryonal brain. The bundles of neuroblasts are
      accompained by slightly differentiated cells, having their own processes
      descending to the surface of the lining. These processes attached to the surface
      of a bundle cover and have no connection with the inner structures of the bundle.
      The use of a scanning electron microscopy allows to detect some new details of
      the behaviour of nerve cells in vitro.

PMID- 1029122
TI  - [Ultrastructural characteristics of localization of lactate dehydrogenase in the
      kidney glomerulus].
AB  - Lactate dehydrogenase was studied in dog's kidney glomeruli using electron
      microscope. Detection of the enzyme in the podocyte confirms the principle of
      structural integration of glycolytical enzyme on the membranes.

PMID- 1029123
TI  - [Relationship between cell division and function. Resistance of the liver to
      toxic effect of CCL4 after partial hepatectomy].
AB  - The necrogenic effect of CCL4 was used as a marker of drug metabolizing function
      of hepatocytes. CCL4 induced a zonal centrolobular necrosis in normal mice. After
      partial hepatectomy, during intensive hepatocyte proliferation, the necrosis area
      in the sections was seen significantly decreased. No damaged cells being observed
      in some instances. The resistance to hepatotoxin is explaned by inhibition of the
      specific cell function during proliferation.

PMID- 1029124
TI  - [Ultrastructure of the enterocytes of the upper 3d of the villi of murine small
      intestine].
AB  - The enterocytes of the upper one-third of the villi of duodenum, ileum and
      jejunum of mice were investigated with the electron microscope. It was found that
      enterocytes moving to the top of the villus underwent regular structural
      rearrangements that involve the appearance of triangular dilatations of the
      intercellular spaces at the cell base, condensation of the mitochondrial matrix,
      reduction of ergastoplasmic reticulum and dictyosome hypertrophy. It is suggested
      that enterocytes leave the top of the villus as structurally and functionally
      valid cells.

PMID- 1029125
TI  - [Method of ultrastructural analysis with the aid of measuring television
      complex].
AB  - The area of the section of presynaptic dense projections of the active zone of
      axondendritic synapses of the rat's cortex was measured using a television
      complex. Tissue specimens were contrasted with phosphotungstic acid. Morphometry
      was carried out in the regime of error correction in measurement, the errors
      arising in scanning process of image. The area of the section of mitochondria,
      lysosome, nucleoli, channels and tanks of the endoplasmic reticulum may be
      measured by the method suggested. Quantitative data, obtained by the morphometry
      of the synapse ultrastructure, may serve a basis for understanding the mechanism
      by which synapses are involved in information processes of the central nervous
      system.

PMID- 1029126
TI  - [Adaptation of a sliding microtome for sectioning of material embedded in epoxy
      resins].
AB  - The employment of a sliding microtome of sectioning plastic embedded material
      with glass knives is described. Using a new knife holder and a modificated device
      for fixing plastic blocks succeeded in cutting sections 1--10 micron thick of
      relatively large pieces of tissue.

PMID- 1029127
TI  - How not to get sued.

PMID- 1029128
TI  - Hospitals and professionals: the relationship is changing.

PMID- 1029130
TI  - Waukesha trustees have a way with the public.

PMID- 1029129
TI  - Sick hospital bonds.

PMID- 1029131
TI  - Licensure: are we doing it as well as we should be?

PMID- 1029132
TI  - Self-audits help boards to mind their own business.

PMID- 1029133
TI  - Regulation: can hospitals tame the paperwork monster?

PMID- 1029134
TI  - A model for physician participation in planning.

PMID- 1029135
TI  - Medical staff privileges: a matter of fairness.

PMID- 1029136
TI  - Atrioventricular heart block--27-year follow-up experience.

PMID- 1029137
TI  - The cost factor in national health insurance.

PMID- 1029138
TI  - Coronary artery disease--a brief report.

PMID- 1029139
TI  - Non-can disability and the highly substandard risk.

PMID- 1029140
TI  - The mortality monograph: a medico-actuarial milestone.

PMID- 1029141
TI  - Hypertension and selection of risks in Japan.

PMID- 1029142
TI  - The correct way to underwrite hypertension.

PMID- 1029143
TI  - Approach to mortality studies of life insurance policyholders with psychiatric
      diagnoses.

PMID- 1029144
TI  - Progress report on Met Scan--a medical data acquistion unit.

PMID- 1029145
TI  - Continuing medical education--where are we headed?

PMID- 1029146
TI  - Purpose and cross-purpose.

PMID- 1029148
TI  - Health services in Denmark.

PMID- 1029147
TI  - Abnormal electrocardiogram in the absence of heart disease.

PMID- 1029149
TI  - Planning a standard psychiatric ward for Israel.

PMID- 1029150
TI  - A short outline of health services planning at central level in the Netherlands.

PMID- 1029151
TI  - Towards greater relevance for the teaching hospital.

PMID- 1029152
TI  - The hospitals of Saudi Arabia.

PMID- 1029153
TI  - Planning for the future today.

PMID- 1029154
TI  - Monitor-N. A comprehensive management information and control system.

PMID- 1029155
TI  - Planning health facilities in developing countries - some case studies and their
      lessons.

PMID- 1029156
TI  - A phased hospital development under conditions of limited resources.

PMID- 1029157
TI  - The morphological evolution of the postwar hospital.

PMID- 1029158
TI  - A selected library for personnel in remote areas: a component of expatriate
      community development.

PMID- 1029159
TI  - Applications of operational research to health care delivery systems and
      facilities planning.

PMID- 1029160
TI  - Future trends in health care in the U.S.A.

PMID- 1029161
TI  - [The problem of help to the dying: ethical considerations].

PMID- 1029162
TI  - [Findings in the remaining antrum after Billroth-II operations (excluded antrum)-
      a contribution to the differential diagnosis of recurrent ulcers with
      hypergastrinemia].

PMID- 1029163
TI  - [Effect of depot somatostatin on gastrin and stomach secretion in normal subjects
      and in patients with Zollinger-Ellison syndrome].

PMID- 1029164
TI  - [The effect of metoclopramide on the basal and meal-stimulated gastrin secretion
      in the healthy subject].

PMID- 1029165
TI  - [The conservative therapy of peptic ulcers in Zollinger-Ellison syndrome].

PMID- 1029166
TI  - [The value of the concentration of carcinoembryonal antigen (CEA) in the plasma
      in first diagnoses and course control of treated gastrointestinal neoplasms].

PMID- 1029167
TI  - [The value of the guaiac test in the early diagnosis of gastrointestinal
      neoplasms].

PMID- 1029168
TI  - [The stump neoplasm in the patient with gastrectomy].

PMID- 1029169
TI  - [Studies on diazepam premedication in peroral endoscopy].

PMID- 1029170
TI  - [Disease value of achlorhydria].

PMID- 1029171
TI  - [Splenectomy without effect on human ulcer formation].

PMID- 1029172
TI  - [The parietal cell-antibody distribution in type I chronic gastritis (isolated
      corpus atrophy)].

PMID- 1029173
TI  - [Chronic hepatitis].

PMID- 1029174
TI  - [Physiology of the portal circulation].

PMID- 1029175
TI  - [Methods for the demonstration of splanchnic hemodynamics].

PMID- 1029176
TI  - [Radiodiagnosis of the portal circulation].

PMID- 1029177
TI  - [Portal hypertension: isotope diagnosis].

PMID- 1029178
TI  - [Systemic circulation in portal hypertension].

PMID- 1029179
TI  - [Humoral and hormonal changes in portal hypertension].

PMID- 1029180
TI  - [Resorption in portal hypertension].

PMID- 1029181
TI  - [Blood coagulation and its disorders in portal hypertension].

PMID- 1029182
TI  - [Portal hypertension--surgical therapy].

PMID- 1029183
TI  - [Methods and results of pressure-adapted arterialization of the liver].

PMID- 1029184
TI  - [Advantages and limitations of the galactosamine model].

PMID- 1029185
TI  - [The significance of age for morphological and biochemical changes in
      galactosamine hepatitis].

PMID- 1029186
TI  - [Experimental immunohepatitis].

PMID- 1029187
TI  - [Experimental murine immunohepatitis--a model for the study of cellular and
      humoral immune reactions against liver tissue].

PMID- 1029188
TI  - [14C-aminopyrine-(pyramidone) respiratory test--a new quantitative liver function
      test].

PMID- 1029189
TI  - [Inhibition of hepatic demethylation by oral contraceptives: analysis by means of
      a respiratory function test].

PMID- 1029190
TI  - [Radiospirometric studies with L-(14C-methyl)methionine and L-(1-14C)methionine
      in patients with liver cirrhosis].

PMID- 1029191
TI  - [Metabolism in vitro and metabolic clearance in vivo of tolbutamide in rats with
      experimental cholestasis].

PMID- 1029192
TI  - [Animal experimental studies on the problem of liver damage by antitubercular
      agents (rifampicin and isoniazide) by means of the galactosamine model].

PMID- 1029193
TI  - [D-penicillamine slowing down the spontaneous regression of carbon tetrachloride
      cirrhosis].

PMID- 1029194
TI  - [The antagonistic effect of silybin-dihemisuccinate on disorders of phosphatidyl
      synthesis in the rat liver].

PMID- 1029195
TI  - [Studies on hypertriglyceridemia in liver diseases by means of measurements of
      hepatic triglyceride lipase and plasma lipoprotein lipase activity in the
      heparinized plasma].

PMID- 1029197
TI  - [The late prognosis of chronic hepatitis].

PMID- 1029196
TI  - [Is hemochromatosis (siderophilia) curable?].

PMID- 1029198
TI  - [Gas chromatography and gas chromatography-mass spectroscopy of amino acids in
      the serum of patients with alcoholic liver cirrhosis].

PMID- 1029199
TI  - [25-hydroxyvitamin D3 in patients with hemihepatectomy].

PMID- 1029200
TI  - [Hepatobiliary function tests with 131I-radio-toluidine blue].

PMID- 1029201
TI  - [Erythrocyte metabolism and membrane lipids in fatty liver due to alcoholism and
      in hyperlipoproteinemia].

PMID- 1029202
TI  - [Radioimmunoassay of serum bile acids].

PMID- 1029203
TI  - [Determination of total bile acids as a routine test for the evaluation of liver
      diseases].

PMID- 1029204
TI  - [Biliary lipids during a carbohydrate reduced, polyene rich reducing diet].

PMID- 1029205
TI  - [Clinical experiences with chemical solubilization of biliary calculi].

PMID- 1029206
TI  - [Morphologic studies on the toxicity and therapeutic scope of chenodeoxycholic
      acid].

PMID- 1029207
TI  - [Amounts, synthesis and turnover of sulfated and non-sulfated bile acids in
      patients with cholestasis].

PMID- 1029208
TI  - [Proof of the necessity and superiority of a three-compartmental analysis for
      human liver function tests by means of intravenous C 14 glycocholic acid].

PMID- 1029209
TI  - [Lipid metabolism in experimental rat liver lesions].

PMID- 1029210
TI  - [Effect of cholestasis on serum enzyme activities and morphology of liver
      mitochondria].

PMID- 1029211
TI  - [Biochemical studies in rats after 2/3 partial hepatectomy and thermocoagulation
      of the thoracic duct].

PMID- 1029212
TI  - [The effect of acute hyperammonisnemia on the biosynthesis of pyrimidine
      nucleotides in the liver].

PMID- 1029213
TI  - [Chronic thioacetamide poisoning as a model for experimental liver cirrhosis].

PMID- 1029214
TI  - [Acute hepatic coma in complete liver ischemia].

PMID- 1029215
TI  - [Effect of D-galactosamine-HCl on the principal chain enzymes in the liver tissue
      and on plasma enzymes and metabolites in the male rat].

PMID- 1029216
TI  - [Extracorporeal bile circulation. A new model for the study of sterol
      metabolism].

PMID- 1029217
TI  - [Effect of insulin and glucagon on the DNA synthesis hepatocyte cultures].

PMID- 1029218
TI  - [Arterial-hepatic compensation in experimental portacaval anastomosis].

PMID- 1029219
TI  - [Results of a 5 year study on carriers of hepatitis B antigen].

PMID- 1029220
TI  - [Study of the course of clinically healthy hepatitis B antigen (HBsAg) carriers].

PMID- 1029221
TI  - [Results of a 5 year prospective study on hepatitis after mass transfusions].

PMID- 1029222
TI  - [Preliminary report on the cooperative DFG study "Acute viral hepatitis"].

PMID- 1029223
TI  - [Virus-like particles in HBsAg negative transfusion hepatitis].

PMID- 1029224
TI  - [Antibodies against HBs antigen in diabetics].

PMID- 1029225
TI  - [Study of the behavior of HBsAg and anti-HBs in 4 dialysis centers].

PMID- 1029226
TI  - [Differences in the course of hepatitis B in dialysis patients and in the
      personnel of a dialysis station].

PMID- 1029227
TI  - [Frequency of hepatitis, HBs-antigen and anti-HBs frequency in patients at the
      Heidelberg hemodialysis center].

PMID- 1029228
TI  - [Does the HBs-antibody prevent hepatitis B?].

PMID- 1029229
TI  - [Serum prealbumin and haptoglobin in acute hepatitis].

PMID- 1029230
TI  - [Changes in factor VIII associated antigens in liver diseases--reasons and
      significance].

PMID- 1029231
TI  - [Study of the plasma-glycosphingolipids in acute hepatitis].

PMID- 1029232
TI  - [Hepatitis and the isoenzymes of alkaline phosphatase].

PMID- 1029233
TI  - [Hyperaldosteronism in acute viral hepatitis, liver cirrhosis and fulminating
      liver failure].

PMID- 1029234
TI  - [The plasma renin activity (basal and after stimulation) in liver cirrhosis in
      connection with the effective renal plasma perfusion].

PMID- 1029235
TI  - [Hepatic aldosterone extraction and perfusion in liver cirrhosis].

PMID- 1029236
TI  - [Studies on the importance of endogenous toxins for the origin of hepatic coma].

PMID- 1029237
TI  - [Statistically controlled comparisons of therapy in acute viral hepatitis with
      reference to liver biopsies].

PMID- 1029238
TI  - [Treatment of hepatic coma by means of hemoperfusion].

PMID- 1029239
TI  - Enzymatic formation of bilirubin and its regulation.

PMID- 1029240
TI  - Sources and kinetics of bilirubin formation in vivo.

PMID- 1029241
TI  - Conjugation of bilirubin--pathophysiological aspects.

PMID- 1029242
TI  - [Introduction to the theme of neurogenic guiding symptoms in internal diseases].

PMID- 1029243
TI  - [Neuropathology of forms of reactions].

PMID- 1029244
TI  - [Clinical aspects of myelopathies].

PMID- 1029245
TI  - [Episodic global amnesia and chronic changed in the level of consciousness].

PMID- 1029246
TI  - [Pain: analysis of syndromes and evaluation of pain].

PMID- 1029247
TI  - [Pain: analysis of syndromes and evaluation of pain described using the angina
      pectoris model].

PMID- 1029248
TI  - [Paraneoplastic neurogenic syndromes].

PMID- 1029249
TI  - [Diagnostic and therapeutic decisions in metabolic/toxic neurogenic leading
      symptoms of internal diseases].

PMID- 1029250
TI  - [Insertiontendopathies and periarthropathies].

PMID- 1029251
TI  - [HBS-(Australia)-antigen. Clinical significance].

PMID- 1029252
TI  - [Neurological aspects of Hodgkin's disease].

PMID- 1029253
TI  - [Hypokalemia in brain diseases].

PMID- 1029254
TI  - [Central hypernatremic hyperosmolar coma].

PMID- 1029255
TI  - [Differential diagnosis of episodic amnesia].

PMID- 1029256
TI  - [Diagnostic criteria and neuropsychiatric leading symptoms in acute intermittent
      porphyria--results of a field study].

PMID- 1029257
TI  - [Latent portacaval encephalopathy].

PMID- 1029258
TI  - [Latent lesions of the brain stem in chronic liver diseases].

PMID- 1029259
TI  - [Early symptoms and early diagnosis in Wilson's disease].

PMID- 1029260
TI  - [Central nervous motor reactions in metabolic disorders].

PMID- 1029261
TI  - [Painful ophthalmoplegia--Tolosa-Hunt-syndrome].

PMID- 1029262
TI  - [Generalized osteosclerosis and Roussy-Levy syndrome in a family].

PMID- 1029263
TI  - [Peripheral nerve lesions in anticoagulant therapy].

PMID- 1029264
TI  - [Experimental chronic immune arthritis in the guinea pig].

PMID- 1029265
TI  - [Immune complex and complement activation in patients with rheumatoid arthritis].

PMID- 1029266
TI  - [The determination of HL-A 27 as a differential diagnostic measure in Bechterew's
      disease].

PMID- 1029267
TI  - [Diagnosis and early recognition of sacroiliitis].

PMID- 1029268
TI  - [Studies on the frequency of cardiac complications in rheumatoid factor positive
      chronic polyarthritis (CP+)].

PMID- 1029269
TI  - [Effect of anti-rheumatic agents on liver cell function in patients with
      rheumatoid arthritis].

PMID- 1029270
TI  - [Radiosynoviorthesis for local treatment of chronic arthritis].

PMID- 1029271
TI  - [Dietetics in internal medicine. Introduction to the theme].

PMID- 1029272
TI  - [Lines of biochemical development in nutritional science].

PMID- 1029273
TI  - [Diet therapy in gout--experimental basis and practical application].

PMID- 1029274
TI  - [Diet therapy of disorders of lipid metabolism].

PMID- 1029275
TI  - [Diet therapy of gastrointestinal diseases].

PMID- 1029276
TI  - [Diet therapy in kidney diseases].

PMID- 1029277
TI  - [Treatment of diabetic coma with small amounts of insulin].

PMID- 1029278
TI  - [Subclinical diabetes in juvenile hypertension].

PMID- 1029279
TI  - [The anti-ketogenic effect of fructose].

PMID- 1029280
TI  - [The mechanism of action of biguanides].

PMID- 1029281
TI  - [Clinical experiences with Des-Phe B1 insulins].

PMID- 1029282
TI  - [Ketogenesis in lipatrophic diabetes and its susceptibility to insulin].

PMID- 1029283
TI  - [Changes in the urine-protein pattern in diabetes mellitus, an early symptom of
      renal microagiopathy].

PMID- 1029284
TI  - [Studies on glomerulopathy in latent hereditary diabetes mellitus in mice].

PMID- 1029285
TI  - [The carbohydrate metabolism in the rat skeletal muscle].

PMID- 1029286
TI  - [The effect of vasoactive substances on the glucose intake and lactate production
      in the isolated soleus muscle of healthy rats].

PMID- 1029287
TI  - [The effect of insulin on the hepatic VLDL-tri-glycerides metabolism].

PMID- 1029288
TI  - [Daily profile of blood lipids under standardized diet with and without nicotinic
      acid].

PMID- 1029289
TI  - [The value of the P/S quotient for the description of the effect of dietary fats
      on the serum cholesterol level].

PMID- 1029290
TI  - [Partial elimination of the ileum in the treatment of hypercholesterinemia].

PMID- 1029291
TI  - [Effect and severity of obesity on serum lipids and serum uric acid].

PMID- 1029292
TI  - [The cause for decreased triglyceride synthesis under chenodeoxycholic acid].

PMID- 1029293
TI  - [Therapy of familial type II hyperlipoproteinemia in adults and children by means
      of sitosterin].

PMID- 1029294
TI  - [The effect of xanthinol nicotinate on the serum lipids and lipoproteins of
      patients with primary hyperlipoproteinemia Type IIb and IV].

PMID- 1029295
TI  - [Effect of clofibrate therapy on the glucagon and insulin secretion as well as on
      the glucose tolerance in patients with type IV hyperlipoproteinemia].

PMID- 1029296
TI  - [Lipoprotein changes with oral contraceptives and in pregnancy].

PMID- 1029297
TI  - [Various plasma lipids with contraceptives of different types and compositions].

PMID- 1029298
TI  - [The behavior of lipolytically released fatty acids in post aggression
      metabolism].

PMID- 1029299
TI  - [Determination of lipid and lipoprotein kinetics by means of the intravenous
      lipid tolerance test in patients with portacaval shunt].

PMID- 1029300
TI  - [Activity of endogenous monoglyceride hydrolase in healthy subjects and patients
      with type IV Fredricksoln's hyperlipoproteinemia].

PMID- 1029301
TI  - [Effect of alpha and beta receptor stimulating drugs on lipid metabolism and the
      lethality of endotoxic shock].

PMID- 1029302
TI  - [The significance of familial disposition for the development of risk factors in
      arteriosclerosis (studies on relatives of a military unit)].

PMID- 1029303
TI  - [Metabolic diseases and osteonecroses].

PMID- 1029304
TI  - [Effect of lipoprotein X on the cholesterol synthesis in the rat liver].

PMID- 1029305
TI  - [Hepatitis B antigen components in liver tissue in correlation to specific blood
      parameters and forms of hepatitis].

PMID- 1029306
TI  - [Further studies on the behavior of free amino acids in the serum of patients
      with arteriosclerosis].

PMID- 1029307
TI  - [Ergometric findings during therapy with D,L-alpha-methylthyroxine-ethylester
      hydrochloride (Etiroxat-HCl)].

PMID- 1029308
TI  - [Magnesium level in the blood in pregnancy].

PMID- 1029309
TI  - [Pathogenesis of hyperuricemia and its treatment by means of rigorous fasting (so
      called null-diet)].

PMID- 1029310
TI  - [Pathogenesis of hyperuricemia due to reducing].

PMID- 1029311
TI  - [Behavior of blood proteins under null diet].

PMID- 1029312
TI  - [Comparative studies on the effect of glucose and sorbitol on the reactive
      increase in insulin in obesity].

PMID- 1029313
TI  - [Pathways of alcohol catabolism].

PMID- 1029314
TI  - [The effect of various purine and pyrimidine derivatives on human pyrimidine
      synthesis].

PMID- 1029315
TI  - [Glucose tolerance and clearance of free plasma fatty acids in liver cirrhosis].

PMID- 1029316
TI  - [Controlled hypoglycemia in the insulin test].

PMID- 1029317
TI  - [Serum fluoride level in the NaF treatment of osteoporosis].

PMID- 1029318
TI  - [Animal experimental disorders of the magnesium balance].

PMID- 1029319
TI  - [The determination of lysozyme in Crohn's disease].

PMID- 1029320
TI  - [Sugar consumption in patients with Crohn's disease].

PMID- 1029321
TI  - [Course studies in patients with Crohn's disease after surgery or
      immunosuppressive therapy].

PMID- 1029322
TI  - [Thrombocytosis in Crohn's disease].

PMID- 1029323
TI  - [Disorders of liver metabolism in hepatitis].

PMID- 1029324
TI  - [Studies on the cellular and humoral immunity in patients with Crohn's disease].

PMID- 1029325
TI  - [The effect of laxatives on the passage time of fluids in the human jejunum].

PMID- 1029326
TI  - [Diagnosis of lactose malabsorption using 14C-lactose].

PMID- 1029327
TI  - [Regulation of enzyme activities in carbohydrate metabolism dependent on the
      diet: various adaptive changes in the rat liver and small intestinal mucosa after
      feeding of fructose or glucose].

PMID- 1029328
TI  - [Cytochrome P-450 and drug decomposing enzymes in the rat small intestinal
      mucosa: localization and control factors].

PMID- 1029329
TI  - [Effect of vasoactive agents on the disaccharidase activity in rat small
      intestinal mucosa].

PMID- 1029330
TI  - [Determination of fecal chymotrypsin as a screening test for exocrine pancreatic
      insufficiency: studies on the reliability of various methods].

PMID- 1029331
TI  - [The frequency of macroamylasemia and the diagnostic value of the amylase
      clearance/creatinine clearance quotient].

PMID- 1029332
TI  - [Conservative therapy and peritoneal dialysis in acute pancreatitis].

PMID- 1029333
TI  - [Retrograde pancreatography in the dog: functional changes in the exocrine
      pancreas].

PMID- 1029334
TI  - [The effect of chylomicrons on the exocrine pancreas secretion in the cat].

PMID- 1029335
TI  - [Intraduodenal magnesium stimulating human pancreatic enzyme secretion and
      emptying of the gall bladder].

PMID- 1029336
TI  - [Atypical courses of viral hepatitis (including fulminant hepatitis)].

PMID- 1029337
TI  - [Colonic stenoses following pancreatitis].

PMID- 1029338
TI  - [Manometric study on the problem of the pyloric sphincter].

PMID- 1029339
TI  - [Endoscopic manometry (EM)--a method for the combined upper gastrointestinal
      tract diagnosis].

PMID- 1029340
TI  - [Intraluminal manometry by means of a new electronic measuring device].

PMID- 1029341
TI  - [Further studies on the liberation of gastrin after intraduodenal administration
      of bile].

PMID- 1029342
TI  - [Stimulation of the H+ secretion and the serum gastrin by means of intraoperative
      electric stimulation of the vagus nerve before and after proximal selective
      vagotomy].

PMID- 1029343
TI  - [Studies on the effect of calcium on gastrin liberation].

PMID- 1029344
TI  - [Histological results of phase biopsies of the stomach in patients with
      achlorhydria, hypo and normochlorhydria and their relationship to the serum
      gastrin level].

PMID- 1029345
TI  - [The effects of preservation at -3 degrees C on the metabolism of rat skin].

PMID- 1029347
TI  - Openness to interorganizational cooperation: a study of hospital administrators.

PMID- 1029346
TI  - The measurements of job characteristics.

PMID- 1029348
TI  - Role dynamics, locus of control, and employee attitudes and behavior.

PMID- 1029349
TI  - The merits of using experts or consumers as members of planning groups: a field
      experiment in health planning.

PMID- 1029350
TI  - Sex stereotypes: an artifact in leader behavior and subordinate satisfaction
      analysis?

PMID- 1029351
TI  - Antecedents of work related expectancies.

PMID- 1029352
TI  - Size and staff professionalization.

PMID- 1029353
TI  - Pathology of the trophoblast and fetal vessels of the placenta in maternal
      diabetes mellitus.
AB  - The morphologic characteristics of the chorial villi from normal full-term
      placentas and from placentas of different clinical types of diabetic women were
      studied. The latter showed early maturation of the trophoblast, higher percentage
      of villi with stromal edema, and higher percentage of vessels of the villous
      trunks with lesions causing partial or total obstruction of the vascular lumen.
      The fact that the diabetic patients were treated suggests that the metabolic
      correction of diabetes mellitus prevents the occurrence or development of the
      multiple disturbances which the disease produces in the evolution of human
      pregnancy.

PMID- 1029354
TI  - Urinary 17-ketosteroids in diabetic and non-diabetic pregnancies.
AB  - The excretion of estriol into the maternal urine is an effective means of
      evaluating the fetus in pregnancies complicated by a number of metabolic
      disorders, such as chronic hypertension, renal disease, pre-eclampsia, etc. It is
      generally used in the management of pregnancies complicated by maternal diabetes
      mellitus even though some question has been raised as to its validity for this
      disorder. In this study we have evaluated estriol precursors in the form of 17
      ketosteroids in the urine of pregnant women with mild diabetes mellitus as well
      as a non-diabetic control group. Urinary total estrogen excretion was also
      determined. Diabetics were found to excrete significantly higher amounts of 17
      ketosteroids than the non-diabetic group. The possible significance of this
      finding in relation to the dynamics of estriol production in pregnancy is
      discussed.

PMID- 1029355
TI  - Deep vein thrombosis in surgery. Detection by the method using labelled
      fibrinogen.

PMID- 1029356
TI  - The significance of bone strain "in vivo".

PMID- 1029357
TI  - [Method of use of x-rays in a cinematic study of joints. Application to the study
      of the thoraco-lumbar spin in the movement plan of lateral inflexion].

PMID- 1029358
TI  - [The weight-bearing surfaces of the femoro-tibial joint].

PMID- 1029359
TI  - [Femoro-patellar strain. Study of femoro-patellar contact surfaces during flexion
      of the knee].

PMID- 1029360
TI  - Study on the surface shape and contours of the femoral head and acetabulum of the
      human joint.

PMID- 1029361
TI  - [A new type of tissue-penetrable stellite. Mechanical and histological study].

PMID- 1029362
TI  - [Measurement by simulation of the shock absorption of a normal and a prosthetic
      hip].

PMID- 1029363
TI  - [Comparative study of the femoral element of various total hip arthroplasties.
      Biomechanical aspects].

PMID- 1029364
TI  - [Mechanical study of Cabot's plate for lumbo-sacral arthrodesis].

PMID- 1029365
TI  - Hip prosthesis with physiological transmission of forces and individually
      isoelastic properties.

PMID- 1029366
TI  - [Centro-medullary nailing of the femur and the tibia using Kuntscher's technic.
      Value of locking the nail].

PMID- 1029367
TI  - [Problems posed by the use of constraint gauges in vivo].

PMID- 1029368
TI  - [Determination of the deformation of in vivo implants. Results of a study of 10
      patients treated with a nail-plate].

PMID- 1029369
TI  - [Determination of the deformation of implants in vivo. Application to the study
      of the consolidation of fractures treated by ostootaxis].

PMID- 1029370
TI  - [Topographical variations of the mechanical properties of the tibia].

PMID- 1029371
TI  - [Study of the behavior in the course of time of the holding power of cortical
      screws in vivo].

PMID- 1029372
TI  - [Objective method of evaluating bone implant deformations in vivo by telemetry].

PMID- 1029373
TI  - The measurement of bone strain "in vivo".

PMID- 1029374
TI  - [Development of the education of pharmacists, with special reference to the city
      of Kecskemet].

PMID- 1029375
TI  - Effects of vagal stimuli of different duration on heart rate and atrioventricular
      conduction.

PMID- 1029376
TI  - Effect of the analogue of cinnarizine AS2 on the cardio-vascular system.

PMID- 1029377
TI  - Coordination between the electrical activity of the small intestine and the colon
      in the ileocaecal region.

PMID- 1029378
TI  - Effect of the analogue of cinnarizine AS2 on peripheral blood circulation.

PMID- 1029379
TI  - Reflex changes of the haemodynamics in hypertonic cats.

PMID- 1029380
TI  - Are the central dopaminergic synapses related to the convulsive-seizure
      threshold?--Effects of central dopaminergic drugs on the picrotoxin convulsive
      seizure threshold. Interaction with diazepam, meta-tolylcarbamide and
      theophylline.

PMID- 1029381
TI  - Comparative study of the effect of caffeine, strychnine and echinopsin on
      learning and memory in albino rats.

PMID- 1029382
TI  - Estimation of time interval elements. II.

PMID- 1029383
TI  - Structure and organizational resource allocation.

PMID- 1029384
TI  - Structural and functional subunits of chromosomes.

PMID- 1029385
TI  - Transcription and chromatin subunit structure.

PMID- 1029386
TI  - Chromosome structure.

PMID- 1029387
TI  - Cytochemical dissection of the mammalian genome.

PMID- 1029388
TI  - Biochemical genetics of human disease.

PMID- 1029389
TI  - Genetic counseling.

PMID- 1029390
TI  - A federal perspective on the role of the journal and planning to enhance health
      and well-being.

PMID- 1029391
TI  - Holistic health: implications for health planning.

PMID- 1029392
TI  - From a concept of health to a national health policy.

PMID- 1029393
TI  - Planners and the end of medicine.

PMID- 1029394
TI  - The effective health planner.

PMID- 1029395
TI  - Health policy guidelines and holistic care.

PMID- 1029396
TI  - An evaluation of the agency assessment program--implications for the Health
      Systems Agency community.

PMID- 1029397
TI  - The frontiers of health planning.

PMID- 1029399
TI  - Hospital planning at HSA.

PMID- 1029398
TI  - From omnibus tinkering to high-level wellness: the movement toward holistic
      health planning.

PMID- 1029400
TI  - The health planner: planning and dreaming for health and wellness.

PMID- 1029401
TI  - The future of pharmacy.

PMID- 1029402
TI  - Evaluation of a college-structured practical experience program.

PMID- 1029403
TI  - Pharmacy College Admission Test (PCAT) as a predictor of academic success.

PMID- 1029404
TI  - Current status of undergraduate, nonprofessional pharmacology courses taught in
      colleges of pharmacy.

PMID- 1029405
TI  - Disillusionment in pharmacy students: a reconsideration with the advent of
      clinical pharmacy education.

PMID- 1029406
TI  - A meaningful experience in laboratory investigation.

PMID- 1029408
TI  - The fifth-year institutional clinical pharmacy program at the Medical University
      of South Carolina.

PMID- 1029409
TI  - Pharmacist-patient interactions in terms of "appropriate behaviors".

PMID- 1029411
TI  - Enrollment report on professional degree programs in pharmacy, fall 1975.

PMID- 1029412
TI  - Enrollment report on graduate degree programs, fall 1975.

PMID- 1029413
TI  - Address of the president and chairman of the board.

PMID- 1029414
TI  - A sense of identity and a sense of the future--address of the president-elect.

PMID- 1029416
TI  - Forward plan for health.

PMID- 1029417
TI  - Significant issues raised by the Study Commission on Pharmacy report--a view from
      the profession.

PMID- 1029418
TI  - Specialty recognition--academic and professional alternatives.

PMID- 1029419
TI  - An analysis of the IOM cost study.

PMID- 1029420
TI  - Institutional resource requirements and cost per student for contemporary
      pharmaceutical education.

PMID- 1029421
TI  - Report of degrees conferred by schools and colleges of pharmacy for the academic
      year 1975-1976.

PMID- 1029422
TI  - [Recommended vitamin intake].
AB  - Vitamins intakes cannot be absolutely established; they depend on basic
      composition of the diet, ecological conditions and physiological status of the
      subject. Nevertheless, approximate norms can be established, which avoid
      deficiencies or overdosages. Dietary and epidemiologic surveys, assays on
      volunteers conducted the commissions of F.A.O./O.M.S. Experts and National
      Authorities to propose values with a practical consensus for vitamins A, B1, B2,
      PP, P, C, D, B12 folates and some other factors.

PMID- 1029423
TI  - [Influence of rapeseed oil feeding on morphology and oxidative properties of
      mitochondria isolated from the rat heart].
AB  - Mitochondria from heart of rats fed a diet rich in rapeseed oil for two months
      from weaning, oxidized oleic acid a little better than those from animals fed a
      control diet containing peanut oil; but their activity decreased much more in
      presence of potassium cyanide which is an oxidation inhibitor. When observed by
      electronic microscopy, mitochondria from heart of rats fed rapeseed oil were more
      mumerous and more mitochondria of great size were encountered as compared with
      control rats. Biochemical data seemed to show a decrease of activity or quantity
      of certain enzymatic systems in mitochondria from heart of animals fed rapseed
      oil. Cyanide could more easily inhibit these enzymatic systems because of their
      deficiency. It can be thought that it is the mitochondria of great size which are
      implicated in this phenomenon since their growth is not accompanied by an
      increase of their content in certain enzymes which are just sensitive to cyanide.
      A mixture richer in mitochondria of big size, thus poorer in certain enzymes for
      an equal protein content in drastic conditions, such as partial anoxia since
      cyanide blocks the respiratory chain.

PMID- 1029424
TI  - [Tolerance and metabolic results of long-term administration of a mixture of
      saturated triglycerides by recto-colic route in rabbits].
AB  - Rabbit's and Dog's colonic absorption of triglycerides is shown in previous
      works. Further, we are studying the possibility to use the rectal route for
      nutritive substances. This way remains now poorly used and an exceptional
      therapeutic. However, bringing triglycerides in adequate state would be an
      energetic, supply, all the more as it is very difficult to provide potent caloric
      source in parenteral nutrition. This is why we investigate, on the Rabbit, the
      issues of chronic administration of glycerides by rectal route, on caloric
      balance and on a biochemical view to seek for in lipid composition of tissues the
      print of lipids administrated by transanal way. The animals are individually
      housed in metabolism units feeding a standard diet and drinking ad libitum. The
      treated subjects are given by transanal way, twice a day, for eight weeds, a sum
      of 1 g/kg of medium chain triglycerides. The metabolic balance-sheet is daily
      drawn. The clinic balance-sheet is set on the end, by biological controls to
      explore the hepatic and renal function (prothrombine ratio, transaminases (SGOT,
      SGPT), ornithine, carbamyl transferase (OCT), urea, total proteins ratio and
      electrolyte imbalance. We measure also the concentration of total lipids plasma
      and tissue (liver, kidney, heart, lungs, perirenal adipose tissue). The
      triglyceride composition and fatty acid composition of different lipids fractions
      of control and treated subjects are analyzed by gas-liquid chromatography. The
      animals support perfectly, without damage, a chronic and massive (1 g/kg/each
      day) administration of medium chain triglycerides by rectal route. The growth of
      treated subjects is normal. On the opposite, they adjust their alimentary
      consumption with the caloric charge of the diet, this is the reason why the
      reduction is about 12p. 100 with respect to the control animals. The coli-rectal
      administration of saturated glycerides produces at middle end only qualitative
      variations of lipids extracts. They essentially affect the triglyceride and fatty
      acid fraction of the tissue lipids, they become intermediate between that of
      control animals and the mixture administered by the transanal way. These results
      prove the integration of the glycerides in the metabolic pathway. They show the
      problem of the colonic absorption for the liposoluble substances. They authorize
      researches in view of a possible caloric assistance by this way.

PMID- 1029425
TI  - [Comparative physiological effects of partially hydrogenated herring and rapeseed
      oils in the rat. 1. Mean-term effects on growth, organ weights and heart
      histology].
AB  - Two partially hydrogenated herring oils, containing 15% or 30% of C 22: 1,
      supplemented or not with linoleic (maize oil), have been fed for 16 weeks to
      growing rats (15% by weight in the diet), and their effects have been compared to
      those of peanut oil (controls), and to those of 2 mixtures of rapeseed oil and
      peanut oil having similar C 22:1 contents (15% and 30%). On the basis of equal
      amounts of ingested food, the growth of the rats is lower with herring and
      rapeseed oil than with peanut oil; this phenomenon is emphasized in the case of
      the non--C 18:2--supplemented herring oils. Herring and rapeseed oils induce an
      increase of liver particularly with the one having the highest content of trans
      fatty acids. Heart lesions have been observed in rats feed herring or rapeseed
      oils, not in the control group. The frequency of these lesions is greater with
      rapeseed oil (11/13) than with herring oils (11/24). This result suggests that
      erucic acid (cis delta 13 docosenoic acid) is more pathogenic than at least some
      of its isomers present in the hydrogenated herring oils (particularly the trans
      isomers). In the second part of this paper, we report the effects of the tested
      dietary fats on organ lipids after very short-term (3-7 days) or mean-term (16
      weeks) experiments.

PMID- 1029426
TI  - [Effect of diet and of the microbial flora of the digestive tract on the
      intestinal pool and fecal excretion of bile acids in the rat: a comparative study
      in axenic, ghotoxenic and holoxenic rats].
AB  - When axenic rats are given a microflora which causes the caecum distension
      present to disappear but does not metabolize bile acids, the intestinal pools and
      fecal excretion of bile acids are intermediary between those of axenic and those
      of holoxenic rats. This flora acts non-specifically on bile acids metabolism by
      changing the physiological characters related to caecal distension in axenic
      rats. The intestinal pools and fecal excretion of bile acids are higher in rats
      given a commercial chow than in those receiving a semi-synthetic feed containing
      the same amount of cholesterol; the difference between axenic and holoxenic rat
      fecal excretions is greater than in rats given the semi-synthetic feed. This
      wider difference is especially due to greater fecal excretion of bile acids in
      holoxenic rats given the commercial diet; it is thus related to modification of
      the gut microbial flora due to diet.

PMID- 1029427
TI  - [Metabolic adaptation to a fatty diet: growth and morphogenesis of Artemia salina
      (L)].
AB  - Dietary AMP deficiency induces the morphogenesis of supernumerary gonopodes on
      abdominal segements. The AMP concentration threshold inducing supernumerary
      gonopodes depends on the lecithin and albumin concentration of the diet. The AMP
      concentration threshold corresponding to maximal xanthine oxidase activity
      depends to the maximal rate of protein biosynthesis. The results suggest the
      existence of a relation between the developmental physiology of Artemia and AMP
      and lipid metabolisms, relation which would imply the activity of xanthine
      oxidase.

PMID- 1029428
TI  - [Epidemic due to group B Coxsackie viruses in a newborn infants' department
      (author's transl)].
AB  - Virological and clinical researches have been done on hospitalized newborn
      infants' with various infectious diseases (respiratory infections, aseptic
      meningitis, serious generalized disease). Initially from some newborn children
      Coxsackie B5 virus has been isolated and later from other patients Coxsackie B3
      virus. The pathological findings, in those newborn who died as a result of
      serious generalized disease were dominated by hemorragic lesions in different
      organs.

PMID- 1029429
TI  - [The behaviour of the seric immunoglobulins in brucellosis (author's transl)].
AB  - The Authors studied the behaviour of the seroproteic picture and of the seric
      immunoglobulins in 34 patients affected with brucellosis, almost all of which
      came from a single epidemic center, some in the initial phase and others in an
      advanced stage. As regards the seroproteins they found a constant increase in the
      globulin, which was more apparent in the beta and gamma fractions. As far as the
      immunoglobulins are concerned they demonstrated an increase in all three classes
      examined, but a clearer one in the IgM at the beginning of the illness. However
      the Authors were not able to find evidence of the usual diphasism probably
      depending on the fact that the primary phase can develope in a pre-clinical
      stage.

PMID- 1029430
TI  - Attempts of phage typing of "Salmonella wien" strains isolated in central Italy.

PMID- 1029431
TI  - [Morphofunctional characteristics of the adrenal glands in the progeny from
      females with experimental hypothyroidism].
AB  - Under study were the morphofunctional features of adrenal glands of 1, 10, 20, 30
      and 40-day-old rats born by females with experimental hypothyrosis obtained by
      bilateral subtotal parathyroidectomy and blocade of the gland functioning by
      mercazolil (3 mkg/kg). The experimental treatment preceded pregnancy. The
      antithyroid drug was injected during pregnancy and lactation. The posterity of
      experimental animals was established to have a decreased need in oxygen as
      compared with controls. Their adrenal glands were of less weight (especially in
      off-springs of parathryodidectomized rats in the neonatal period). There are a
      number of morphometrical and histochemical signs suggesting the suppression of
      the functioning of the cortical and medullary substance, including the period of
      adaptation of the organism to the extrauterine life.

PMID- 1029432
TI  - [Position of the embryos of American mink in the fetal chamber at different
      stages of development].
AB  - The spacial position of American mink embryos is characterized by regular changes
      and is associated with the development and formation of provisory embryonic
      organs and the uterus. After the implantation the longitudinal axis of the
      embryo's body lies perpendicularly towards the long axis of the uterus horn. From
      the end of the 22nd day till birth the embryo moves along the antimesometral side
      of the fetal chamber by rotation counter clockwise relative to the point of
      attachment of the alantois stalk. On the 20th day prior to delivery the embryo's
      body bent as a coil takes a vertical position its fore-part is disposed in the
      yolk sac cavity, and the hinder part is in the exocoelom. During 17 days before
      birth the embryo "rolls out" from the yolk sac cavity and occupies the low
      position in the longitudinal posture of the body. During the following 6 days the
      prefetus moves towards the opposite side wall of the fetal chamber, takes the
      upper position and keeps a longitudinal position till the end of the embryonic
      life.

PMID- 1029433
TI  - [Cytological characteristics of the gonocytes in the course of their migration in
      early rat embryos].
AB  - The work was carried out in 23 rat embryos from 9,5 to the 11th day of
      development. In 9,5-day embryos the primary sex cells are localized in the
      mesenchyma of the allantois and in the intestinal entoderm. Later they migrate
      either with the blood flow or on the surface of cellular layers towards gonad
      germs which are reached by the 11th day of the intrauterine development. In the
      course of this process there occur structural and cytochemical changes in
      gonocyte nuclei. The nucleolus is replaced to the periphery of the nucleus,
      around it there appears a rim intensively stained with methylene green. Chromatin
      has a shape of thin threads. These changes of the nuclei seem to be associated
      with an increased synthesis of r-DNA and hence with the synthesis of substances
      having the role to prevent the somatic differentiation of primary sex cells in
      the course of migration.

PMID- 1029434
TI  - [Contact microscopic and histochemical studies of the placenta in normal and
      pathological pregnancy].
AB  - The placenta was studied in 70 women: 19 of them had physiological pregnancy and
      51 had pregnancy complicated with late toxicosis. Lesions in the placenta have
      been shown to increase with the growing severity of toxicosis, and compensatory
      potencies--to decrease. In late toxicosis the expansion of desorganization and
      reparation in the placenta occurs from the center towards periphery, the
      peripheral parts playing the role of reserved zones of the placenta, keeping high
      functional activity.

PMID- 1029435
TI  - [Changes in the human fetal membranes in late pregnancy toxicoses].
AB  - Changes of a destructive and adaptational character have been revealed in the
      extraplacental coats in late toxicoses of pregnant women by histological,
      histochemical and spectrophotometrical methods. The intesity of the apotomical
      way of the glucose oxidation decreased in the aminiotic epithelium. While the
      activity of enzymes converting the lipid decomposition products into glycolysis
      increased. The glucose utilization in the chorial epithelium occurs mainly due to
      anaerobic glycolysis. Histochemical methods have established a high content of
      acid glucoaminoglycanes in the smooth chorion under these pathological conditions
      and the appearance of fibrinoid deposits on the border with the decidual tissue.
      The number of polyploid cells containing a considerable amount of RNA has been
      found to increase in the amniotic and chorial epithelium by spectrophotometric
      methods. The possible role of the extraplacental coats of the fetus in
      pathogenesis of late toxicoses is discussed.

PMID- 1029436
TI  - [Localization and volume of the derivatives of the prechordal plate of the
      cephalic gut in vertebrates].
AB  - In order to determine the localization and volume of the prechordal lamina
      derivatives the initial stages of histogenesis of the cephalic gut epithelium
      lining were studied in embryos of chickens and mammals (rabbits, rats, mice) in
      early terms of the formation of the fore-part of their digestive tube. It has
      been established that the derivatives characteristics of the prechordal lamina
      such as the cephalic end of the chordal, larval mesodermal somites, are formed by
      the real enterocelic means only from the entodermal epithelium of the Seessel's
      pouch walls which is the most cranial end of the cephalic gut. In other parts of
      the dorsal wall of the pharynx, the more of the oesophagus, the prechordal lamina
      derivatives fail to be determined. This fact shows that the localization of the
      prechordal lamina coincides with the disposition of the Seessel's pouch lining,
      the histological nature of its material being identical to the entoderm.

PMID- 1029437
TI  - [Effect of genetic factors on the rate of embryonic growth in mink].
AB  - A comparative analysis of the growth rate of embryos of two groups of minks
      differing in the coat colour was carried out. For comparison, 10 development
      stages with progressively more complicated morphology were taken. It has been
      demonstrated that the difference in the emmbryo growth rate between the standard
      and "sapphire" colour forms appear at the "pre-fetal" and, especially, "fetal"
      period of development.

PMID- 1029438
TI  - Panel IV: The pros and cons of organized rehabilitation on the basis of repeated
      short-term supervised programmes. Introduction.

PMID- 1029439
TI  - Arguments for a comprehensive rehabilitation program.

PMID- 1029440
TI  - Optimal function and health.
AB  - Regular physical activity is essential for the optimal function of many vital
      organs and tissues, and for general function. I am less sure about its direct and
      significant effects in the area of preventive medicine, but I can mention much
      indirect evidence to justify a whole-hearted promotion of physical exercise.
      Information about diet and exercise should be tied together. My present
      prescription for exercise is as follows: Daily -- at least 60 minutes of physical
      activity, not necessarily vigorous, nor all at the same time. During your daily
      routine, moving, walking, climbing stairs, etc., whether for one minute 60 times
      per day, 12 minutes 5 times a day, or any combination totalling 60 minutes, will
      burn up approximately 300 kcal (1.2MJ). Weekly -- at least two or three periods
      of 30 minutes of intermittent or sustained activity at submaximal rate of work
      (brisk walking, jogging, cycling, swimming, cross-country skiing, gymnastics
      etc.) are necessary for maintaining good cardiovascular fitness, and will consume
      an additional 750 kcal per week (3MJ).

PMID- 1029441
TI  - Pros and cons of organized rehabilitation.

PMID- 1029442
TI  - Pros and cons of rehabilitation in sanatoria.

PMID- 1029443
TI  - Panel IV: The pros and cons of organized rehabilitation on the basis of repeated
      short-tern supervised programmes. Discussion.

PMID- 1029444
TI  - Panel V: Acceleration of collaterals due to physical activity--dogma or fast. A
      misguided goal or unrealized objective?--introduction.
AB  - The hypothesis drawn from Eckstein's study of dogs [5] suggests that collateral
      circulation (measured retrograde coronary collateral flow) could be enhanced in
      man provided that the coronary arteries were partially obstructed before
      training. The currently available data on the effects of exercise training on
      arteriosclerotic heart disease subjects with significant, but not complete,
      obstruction, and without collateral vessels before training, indicate that
      visible coronary collateral vessels do not develop unless further coronary
      obstruction progresses to complete or near complete occlusion. Although the above
      hypothesis is not supported by the angiographic studies to date, final judgment
      should be held in abeyance until data are presented on the collateral flow and
      regional myocardial perfusion in exercise-trained human subjects with
      arteriosclerotic heart disease.

PMID- 1029445
TI  - Collateral circulation and regional myocardial function.

PMID- 1029446
TI  - Acceleration of collaterals by physical activity?

PMID- 1029447
TI  - Does exercise training enhance collateral circulation?

PMID- 1029448
TI  - Panel V: Acceleration of collaterals due to physical activity--dogma or fact.
      Discussion.

PMID- 1029449
TI  - Panel VI: Critical evaluation of studies concerning mortality and morbidity in
      C.H.D. patients who either have or have not participated in rehabilitation
      programmes. Introduction.

PMID- 1029450
TI  - Rehabilitation, mortality and morbidity in C.H.D.

PMID- 1029451
TI  - Morbidity and mortality after myocardial infarction.

PMID- 1029452
TI  - Physical training after myocardial infarction.

PMID- 1029453
TI  - The WHO rehabilitation study.

PMID- 1029454
TI  - Panel VI: Critical evaluation of studies conc-rning mortality and morbitidity in
      C.H.D. patients who either have or have not participated in rehabilitation
      programmes. Discussion.

PMID- 1029455
TI  - Critical evaluation of cardiac rehabilitation. Conference summary.

PMID- 1029456
TI  - Physical activity as preventive measure in coronary disease.

PMID- 1029458
TI  - Physiological evaluation of an exercise test.

PMID- 1029457
TI  - Exercise training as a therapeutic modality.
AB  - At present we have no data to assure us that physical activity changes or
      prevents the development of coronary atherosclerosis or that it changes the
      progression of the disease which is already present. The data are excellent that
      in about 85% of patients with coronary disease, exercise training has beneficial
      personal and societal effects. However, even this opinion must be subjected to
      critical scrutiny. Several (controlled and randomized) studies of the effects of
      exercise training on arteriosclerotic heart disease subjects are in progress, in
      the United States, in Canada, and in Europe. The National Exercise and Heart
      Disease Project in the U.S.A has already accessed 600 arteriosclerotic heart
      disease subjects and expects to attain the target study population of 800
      subjects by 1 June 1976. We msut be prepared and willing to accept the results of
      such rigorously controlled studies. In another four to five years of follow-up,
      the basis for our present views will be either confirmed or rejected -- although
      most of us anticipate a validation of our present opinion, viz., exercise
      training enhances the quality of life, and coping capacity, even though the
      direct effects on the course of coronary atherosclerosis have not been
      demonstrated.

PMID- 1029459
TI  - Exercise as preventive measure: a controversion.

PMID- 1029460
TI  - Panel I: Physical activity as primary or secondary preventive measure in coronary
      heart disease: yes or no? Discussion.

PMID- 1029461
TI  - Panel II: The pros and cons of early mobilization and of the convalescent phase
      in rehabilitation.

PMID- 1029462
TI  - Are we mobilizing early enough?
AB  - 1 A review of experiences with a shorter post-myocardial infarct hospital stay
      has been presented. 2 A seven-day hospital stay in selected patients appears
      reasonable and safe. 3 Further multi-center controlled studies to enlarge on this
      experience is proposed. 4 The socioeconomic impact of a shorter hospital stay and
      earlier return to work, in higher percentages, would be striking.

PMID- 1029463
TI  - Early mobilization and convalescent phase.

PMID- 1029464
TI  - A critique of ambulation studies.

PMID- 1029465
TI  - Early mobilization, pros and cons.

PMID- 1029466
TI  - Introduction.

PMID- 1029467
TI  - Panel II: The pros and cons of early mobilization and of the convalescent phase
      in rehabilitation. Discussion.

PMID- 1029468
TI  - Panel III: Pyschological aspects, placebo effect and rehabilitation methodology.

PMID- 1029469
TI  - Rehabilitation methodology: international survey.

PMID- 1029470
TI  - The U.K. clinician's approach.

PMID- 1029471
TI  - The functional of a model and an operational system.

PMID- 1029472
TI  - Panel III: Psychological aspects, placebo effect and rehabilitation methodology.
      Discussion.

PMID- 1029473
TI  - [The Casoni intradermal reaction in the diagnosis of human hydatidosis].

PMID- 1029474
TI  - [Sensitivity and specificity of hemagglutination and Casoni intradermal tests in
      the diagnosis of human hydatidosis (author's transl)].

PMID- 1029475
TI  - [Seroepidemiology of hydatidosis in Chile. A preliminary study in the Province of
      Concepcion (author's transl)].

PMID- 1029476
TI  - [The presence of Anisakis sp. larvae in the Pacific jack mackerel, Trachurus
      murphyi, Nichols, 1920. (some comments on their relation with human eosinophilic
      granuloma) (author's transl)].

PMID- 1029477
TI  - [Mebendazole oral suspension in the treatment of enterobiasis, ascariasis and
      trichuriasis in children. Therapeutic yield of a single dose in enterobiasis
      (author's transl)].

PMID- 1029478
TI  - [Teladorsagia davtiani Andreeva and Satubaldin, 1954 (Nematoda
      Trichostrongylidae) in sheep from Chile (author's transl)].

PMID- 1029479
TI  - [Ascaris suum Goeze, 1782 in sheep from the Province of Valdivia, Chile (author's
      transl)].

PMID- 1029480
TI  - [Tinidazole in the treatment of symptomatic intestinal amebiasis in children
      (author's transl)].

PMID- 1029481
TI  - [The problem of circadian rhythms].

PMID- 1029482
TI  - [Mathematical problems of circadian rhythms].

PMID- 1029483
TI  - [Rhythmic activity in the pineal gland].

PMID- 1029484
TI  - [Nyctameral variations of adenohypophyseal hormones].

PMID- 1029485
TI  - [The circadian rhythms of the kidney].

PMID- 1029486
TI  - [Emotional rhythms in psychiatry].

PMID- 1029487
TI  - Nucleolar vacuoles as manifestations of nucleolar genes.

PMID- 1029488
TI  - [Change in the nociceptive reactions caused by dental pulp stimulation during
      excitation of the midbrain].
AB  - It was demonstrated in chronic experiments on cats that stimulation of certain
      midbrain regions decreased or fully depressed the pain reaction evoked by dental
      pulp stimulation. The antinociceptive effect depending on the parameters of the
      brain stimulation was shown in differential change of the separate motor and
      vegetative and emotional - behaviour components, forming a general pain reaction.
      A poststimulation analgesia was revealed and the dynamic of restoration of
      different pain manifestations after the cessation of brain stimulation was
      traced. Possible mechanism of the realization of the antinociceptive effect are
      discussed.

PMID- 1029489
TI  - [Dependence of the evoked potentials of the auditory cortex on the parameters of
      acoustic stimulus].
AB  - Experiments were conducted on 40 rabbits; a study was made of the dependence of
      the amplitude and the latent period of the auditory evoked potentials on the
      intensity, duration, accretion front, frequency and the rhythm of the acoustic
      stimuli (the intervals between them). The intensity of the stimuli, the accretion
      front and the interstimulus intervals proved to influence the induced potential
      parameters.

PMID- 1029490
TI  - [Changes in the selfexcitation reaction in rats under the effect of modulated
      electromagnetic field].
AB  - The effect of electromagnetic field with various modulation frequencies (2, 7,
      and 50 hertz) on the reaction of selfstimulation was studied in rats. The
      frequency of 2 hertz proved to cause a primary increase in the incidence of the
      selstimulation reaction, followed by its depression; the frequency 7 hertz at
      first failed to alter the selfstimulation intensity and then led to the gradual
      reduction of the incidence of the selfstimulation reaction; the frequency of 50
      hertz depressed the selfstimulation reaction practically from the very beginning.
      The changes in the selfstimulation reaction were independent of the localization
      of the stimulating electrodes, but were determined by the frequency of the EMF
      modulation.

PMID- 1029491
TI  - [Effect of sulfhydryl compounds on the automatism of the pacemakers].
AB  - Experiments were performed on the isolated rabbit hearts and also on the hearts
      with complete atrioventricular block; a study was made of the effect of an excess
      or deficiency of the sulfhydryl groups on the automatism of the cardiac pace
      makers. Unithiol and cysteine in concentrations of 1-10(-6)-1-10(-4) g/ml were
      used as donors of sulfhydryl groups; deficiency of these groups was induced by
      the alloxan administration in concentrations of 1-10(-5)-5-10(-5) g/ml. Changes
      in the sulfhydryl group content produced no marked effect on the automatism of
      the synoatrial node. An excess of sulfhydryl groups promoted poststimulation
      depression of the automatism of the potential pace makers of the cardiac
      ventricles and could lead to the origination of Luciani's periods. On the
      contrary, in case of a deficiency of the sulfhydryl groups there was a sharp
      elevation of the automatism of the ventricular pace makers, the atrioventricular
      conduction became disturbed, and the poststimulation depression of the automatism
      became considerably diminished. Disturbances of the cardiac activity caused by
      the sulfhydryl group deficiency were completely eliminated by unithiol or
      cysteine.

PMID- 1029492
TI  - [Relationship between the frequency and amplitude of myocardial contractions in
      rats adapted to heat].
AB  - Papillary muscles from the left ventricle of rats contracted under the effect of
      electrostimulation with the frequency of 0.2 c. p. s. in Krebs' solution at 28
      degrees C. A study was made of the contraction amplitude with the increased
      stimulation frequency. Following preliminary heat adaptation (3 hours a day at 35
      degrees C for one month) the contraction amplitude of the myocardium of the
      adapted animals with a high frequency was greater than the control level. This
      difference persisted at 36 degrees C and disappeared at 25 degrees C. Apparently
      adaptation leaves a definite structural trace in the cells of the cardiac muscle.

PMID- 1029493
TI  - [Effect of distribution of the stimulation frequency in the volley on post
      contraction hyperemia of the gastrocnemius muscle of cats].
AB  - The influence of  stimulation frequency distribution in a volley on postexercise
      (postcontraction) hyperemia was studied in acute experiments on cat gastrocnemius
      muscle. The initial high frequency of the rhythmic volley augmented the
      postcontraction hyperemia indices (the peak blood flow and an additional blood
      volume).

PMID- 1029494
TI  - [Role of intermediate products of prothrombin proteolysis by thrombin in the
      stimulation of the anticoagulation system of blood].
AB  - Two components - the intermediate product  1 (P-1) converting under certain
      conditions into thrombin, and product 2 (P-2) which possesses no such properties
      were isolated from the products of prothrombin proteolysis by thrombin. The
      intravenous injection of the P-1 to rats lengthened the blood coagulation time
      and plasma recalcification. The sum total fibrinolytic activity proved to
      increase and the fibrinogen concentration - to decrease. A sharp 5-fold rise of
      the nonfermentative fibrinolysis was observed. It seems that this effect of the
      anticoagulating and fibrinolytic potential mobilization was stimulated by the
      response of the second anticoagulating blood system.

PMID- 1029495
TI  - [Seasonal changeability in the leukocytic composition of blood in dogs].
AB  - The leukocyte blood composition was studied for seven years in dogs kept
      outdoors. The lymphocyte count proved to be higher from May to September than
      from November to March. Variations in the neutrophil and monocyte count were
      subject to reverse regularity. Changes in the total leukocyte count failed to
      coincide with the seasonal periodicity.

PMID- 1029496
TI  - [Role of reactions of large-capacity blood vessels in the pathogenesis of
      experimental cardiogenic shock].
AB  - Reaction of the capacitance vessels of the abdominal cavity and the pelvis was
      studied in dogs with the cardiotoxic myocardial necrosis complicated by the
      cardiogenic shock. The deposit of a significant volume of the circulating blood
      in the venous part of the vascular reservoir of the abdominal cavity and the
      pelvis was observed in the course of the first minutes of acute myocardial
      necrosis. A substantial role of reduction of the venous return to the heart in
      the pathogenesis of the hemodynamic disturbances accompanying the development of
      the cardiogenic shock is emphasized.

PMID- 1029497
TI  - [Role of the biological activity of serotonin in the production of the "shock
      lung" syndrome].
AB  - The influence of the serotin biological activity on forming the "shock" lung
      syndrome was revealed in experiments on rats. Tachyhyperpnea with predominance of
      functional emphysema and a small number of atelectic tissue areas were observed
      in the animals with traumatic "shock" during the serotonin hypersecretion.
      Tachyhypopnea with a significant predominance of atelectiv areas was seen during
      the serotonin hypoproduction.

PMID- 1029498
TI  - [Effect of hyperoxia on the rate of restoration of blood composition after blood
      loss].
AB  - Regeneration of the peripheral red blood was considerably retarded in the anemic
      rabbits (blood letting of 2% of body weight) after a 5-hour exposure to the
      hyperoxiconditions (98% of oxygen in the inhaled air, 2 ata).

PMID- 1029499
TI  - [Effect of thyrotoxicosis on the activity of proprioceptors of the skeletal
      muscles].
AB  - A study was made of the influence of prolonged administration of the thyroid
      hormones on the pulse activity of the cat soleus muscle spindles. In the animals
      with thyrotoxicosis the response of the primary endings of the spindles on the
      continuously acting and sudden rapid extension proved to be considerably enhanced
      both during the dynamic and the static phase. The frequency of discharges of the
      secondary endings showed no significant changes. It is supported that the changes
      in the activity of the primary endings observed were connected with the
      disturbances in the metabolism of the muscle and also with its atrophy.

PMID- 1029500
TI  - [Age characteristics of acid-base equilibrium and the blood coagulation system in
      starvation].
AB  - The state of the acid-base balance and of the blood coagulation system was
      studied in starvation of young (5-6-month-old) and old (24-26-month-old) male
      rats during starvation. The periods of the maximal changes coincided in both
      systems; in the young animals the onset of the acidotic crisis and
      hypercoagulation development occurred earliear and were more pronounced. Old
      animals proved to be more resistant to the conditions of starvation and died
      later than the young ones.

PMID- 1029501
TI  - [Acetylcholinesterase in aging of human erythrocytes].
AB  - Acetylcholinesterase possessed a different activity in the membranes of young,
      mature and old human erythrocytes - it was greatest in the mature and least in
      the old cells. In the young and mature erythrocytes the enzyme existed in the
      form of 3- and in the old ones in the form of 2-molecular components. The data
      obtained suggested that the changes in the structural organization of
      acetylcholinesterase in the red cell membrane had a direct relationship to the
      aging of these cells.

PMID- 1029502
TI  - [Relationship between the systems of activation of fatty acids and ademine
      nucleotide translocase in the mitochondria].
AB  - Experiments were conducted on freshly isolated rat liver mitochondria and
      mitochondria subjected to ageing by two different methods. It was shown that the
      work of the mitochondrial system of fatty acid activation could lead to
      inhibition of the adenine nucleotide transport through the internal mitochondrial
      membrane. Inhibition of adenine nucleotide translocase was eliminated by
      preincubation of mitochondria with carnitine. The presence in the mitochondrial
      preparations of fatty acids in the concentration adequate for induction of
      inhibition of addition of CoA and ATP served as a preculiarity of adenine
      nucleotide translocase inhibition of the ageing mitochondria. The data obtained
      permitted to make a supposition on the participation of acyl-CoA formed by the
      mitochondrial acyl-CoA-synthetase in the regulation of adenine nucleotide
      transport into the mitochondria.

PMID- 1029503
TI  - [Activity of various enzymes of energy metabolism of the myocardium after
      neurogenic injury].
AB  - A 3-hour electrostimulation of the aortic arch in rabbits was followed by the
      exhastion of the tissue noradrenaline stores in the myocardium accompanied by
      increase in the activity of the glycolysis enzymes and of the enzyme limiting the
      process of the pentosophosphate route-G-6-PDH. The use of noradrenaline precursor
      - 1-DOPA restored the noradrenaline level in the myocardium completely after a 48
      hour stimulation. Simultaneously there were noted no changes in the activity of
      the enzymes under study caused by the stimulation of the aortic arch. The data
      obtained confirmed the important role of the sympathetic nervous system and of
      its mediator - noradrenaline in the mechanism of the tissue metabolism
      regulation, whose derangement played a significant role in the development of
      dystrophic lesions of the heart tissue.

PMID- 1029504
TI  - [Effect of visual deprivation on the composition of structural proteins of the
      visual system of rabbit brain].
AB  - Composition of membrane proteins of the visual system structures of normal and
      dark-reared rabbits (for 2 1/2 months from birth) was studied by using
      polyacrylamide gel electrophoresis. Solubilization of membrane proteins was
      carried out using a 1% solution of Triton X-100 and a 0.1% solution of sodium
      dodecylsulfate, in succession. One fraction representing the fraction of high
      molecular proteins was absent in membrane proteins of the visual analyser in the
      dark-reared animals; there was also a change in the percentage content of
      proteins in different fractions in comparison with the normal. The data obtained
      led to the conclusion that visual deprivation caused marked quantitative and
      qualitative reconstruction in the composition of membrane proteins of the brain
      with some specific characteristics for the formation of the visual analyser.

PMID- 1029505
TI  - [Structural-mechanical properties and swelling of the protein complexes of
      hyaluronate and protein-chondroitin-4-sulfate].
AB  - It was shown that the mechano-structural strength and swelling of gels consisting
      of gelatine and potassium hyaluronate (PH) or potassium protein-chondroitin-4
      sulphate (PPCS) depended on the correlation of the components. Low PH and PPCS
      concentrations showed a minimal mechano-structural strength and a maximal
      swelling of gels. In the zones of neutralization of the positive electrical
      charges of gelatine by macropolyanions a high mechano-structural strength
      coincided with a minimal swelling. With high PH concentrations the mechano
      structural strength and swelling of gels became equal to those of pure gelatine;
      and with high PPCS concentrations there was noted an additional parallel increase
      in the strength and swelling of gels.

PMID- 1029506
TI  - [Collagen-polysaccharide gel as a model of intercellular substance of the
      connective tissue].
AB  - Gel samples forming at 37 degrees C in the solutions containing tropocollagen and
      various polysaccharides were examined by electron microscopy. Contracting gel
      clots formed in the solutions containing chondroitin sulfate, proteoglycine from
      the tracheal cartilage, gum arabic. Electron microscopy showed such clots to be
      permeated with collagen fibrillae with transverse striations and a period of 640
      A. An association between the density of the forming gel and the nature of the
      polysaccharide component is discussed. Gel forming in the solutions containing
      tropocollagen and various polysaccharides is regarded as a model of the
      connective tissue intercellular substance.

PMID- 1029507
TI  - [Study of metabolic mechanisms of the isolated and combined effect of a chemical
      allergen].
AB  - Biochemical study of the activity of the enzyme systems of different localization
      in the cell connected with the subcellular structures - lysosomes (hyaluronidase,
      N-acetyl-beta-D-glucosaminidase, beta-glucosidase) and hyaloplasm-soluble
      (aldolase of neuraminic acid), and also a study of the state of the enzyme
      substrate groups, belonging to the immunoreactive biopolymeres containing a
      carbohydrate (glucoproteins, glycosaminoglycanes) was carried out in the tissues
      of different organs (the liver, kidneys, small intestine, skin) and in the blood
      serum of albino rats exposed to the isolated and joint (in combination with
      various doses of ultraviolet irradiation) action of the chemical allergen
      (dinitrochlorbenzene). General and specific regularities of metabolic reactions,
      the appearance of which could presumably be connected with the development of
      delayed allergy were revealed.

PMID- 1029508
TI  - [Effect of the spleen extracts on primary immune response in mice].
AB  - Experiments were conducted on mice. Direct Jerne's test demonstrated a
      possibility of intensification of the primary immune response in the sexually
      mature mice under the effect of the splenic extracts. The significance of the
      extract dose and of the time of administration for the manifestation of the
      stimulating action was studied.

PMID- 1029509
TI  - [Intensification of cellular immune response by immunization of mice with the
      cells preincubated in interferon].
AB  - Mice F1(CBA X C57BL/6) were immunized intraperitoneally with a single injection
      of L-1210 cells preincubated in interferon or control "false" preparation. CBA
      mice were injected with MX-11 cells: similarly treated according to the same
      scheme. Injection of interferon-treated cells was accompanied by the enhancement
      of the cellular immune response. The greatest cytotoxic activity was possessed by
      the lymphocytes of mice to which M-11 cells were administered together with
      interferon in which the cells were formerly incubated.

PMID- 1029510
TI  - [Appearance of entodermal antigen in the mouth mucosa of dogs in recurrent
      spontaneous stomatitis].
AB  - An additional component absent in the same areas of the mouth under normal
      conditions appeared in dogs with spontaneous stomatitis in the ectodermal
      derivatives (mucosa of the cheeks, tongue and the hard palate). This component
      proved to be fully identical to the antigens of the mucosa of the soft palate,
      esophagus, stomach, small and large intestine, which were entodermal derivatives.
      No entodermal antigen was revealed in the other organs and tissues under study.

PMID- 1029511
TI  - [Carcinogenesis in male and female mice (CBA X C57/BL) F1 induced by polycyclic
      aromatic hydrocarbons].

PMID- 1029512
TI  - [Chemiluminescence of the mouse liver after administration of a cancerogenic
      substance into the body].
AB  - Regular alterations in the liver chemifluorescence intensity occurred at various
      periods after injection of a carcinogen (9,10-dimethyl-1,2-benzantracene) to
      mice. A possible relation of this phenomenon to the accumulation of the
      endogenous blastomogenic substance in the liver is considered.

PMID- 1029513
TI  - [Sensitivity of the early mouse embryos to antifolic preparation chloridine].
AB  - A study was made of antifolic preparation chloridine (2,4-diamino-5-p-chlorphenyl
      6-ethylpyrimidine) on the cleavage of CBA mouse embryos. Chloridine failed to
      influence the development of early mouse embryos in the maternal organism and
      considerably inhibited the cleavage of embryos explanted into the chloridine
      containing medium. Chloridine sensitivity in the mouse and rat embryos was
      compared and a conclusion was drawn on the absence of interspecies differences in
      their reaction to teratogen at the level of the embryonic cells.

PMID- 1029514
TI  - [Effect of antenatal administration of diethylstilbestrol and progesterone on the
      blood system of newborn rats].
AB  - The effect of sex hormones administered to pregnant women on the blood system of
      their progeny was revealed. The changes were noted in different portions of the
      system: the peripheral blood, bone marrow, spleen, liver. The sex hormones
      intensified the hemopoiesis in the bone marrow and the spleen of the fetus and
      inhibited it in the liver. The noted shifts were assessed as the process of
      acceleration of the functional maturation of the blood system maturation in the
      fetus.

PMID- 1029515
TI  - [Effect of preliminary stress on mitotic activity of the regenerating liver].
AB  - Male rats were exposed to 14- or 24-hour immobilization before partial
      hepatectomy. Some of these animals were given subcutaneous theophylline
      injections immediately after and the next day after the immobilization. A
      tendency to increase of the mitotic activity of the regenerating liver was seen
      in the stress-subjected animals. This effect was particularly pronounced in rats
      given theophylline.

PMID- 1029516
TI  - [Autoradiographic study of the rate of collagen synthesis under conditions of
      stimulation of the wound process].
AB  - A study was made of the rate of the tropocollagen synthesis by the granulation
      tissue fibroblasts and of its passage into the intercellular space in control
      animals and under conditions of stimulation of the wound process by potassium
      orotate, one of the pyrimidine series derivatives. It appeared that the process
      of tropocollagen synthesis became accelerated under the effect of the stimulant;
      collagen fiber precursor appeared in the intercellular space earlier than in
      control and became included into the fibrous structures of the granulation
      tissue, this correlating with the intensification of the RNA synthesis in the
      fibroblast nuclei and an accelerated passage of the newly-synthesized RNA from
      the nucleus into the cell cytoplasm under analogous conditions. There was noted
      no sharp excess of collagen in the granulation tissue of animals given potassium
      orotate.

PMID- 1029517
TI  - [Role of the mesothelium of the parietal peritoneum in the process of absorption
      of true solutions and india ink suspension from the abdominal cavity].
AB  - The method of electron microscopy was applied to the study of absorption from the
      abdominal cavity of hypotoanic, physiological, hypertonic solutions and of the
      Indi-ink suspension on physiological saline. Quantitative assessment of
      pynocytosis was conducted on electron microphotographs. Passage through the
      mesothelium of true solutions was realized by way of diffusion through the
      cytoplasm of its cells and by the intercellular spaces; as to the India ink
      suspension, it passed only by way of the open intercellular spaces. Pynocytosis
      in the mesothelial cells coursed from their basal portion to the apical one and
      was directed to the balancing of the concentration of the protein and salt
      composition in the serous fluid.

PMID- 1029518
TI  - [Healing of experimental wounds under the effect of x-ray irradiation at high
      altitude].
AB  - Experiments were conducted on 969 mature rabbits; combined radiation injury (in
      general irradiation with 500 r and even more so in local irradiation with 2000 r)
      inflicated during the first two adaptation phases (particularly the first one) to
      the high altitide (3379 and 3640 m above the sea level) led to more profound
      morphological changes in the tissues and to the greater delay in the healing of
      the penetrating wounds on the pinna than in the valley (820 m above the sea
      level).

PMID- 1029520
TI  - Trying to sort out the health care boondoggle.

PMID- 1029519
TI  - The social origins of cancer.

PMID- 1029521
TI  - New careers in genetic counseling.

PMID- 1029523
TI  - Prescription for premed students.

PMID- 1029525
TI  - [Usefulness of the early study of intrathoracic digestive anastomoses].
AB  - The appearance of a dehiscence after an operation of oesophageal resection and
      reconstruction with stomach, jejunum or colon, constitutes a highly serious event
      frequently leading to the patient's death. Early recognition of dehiscence is
      therefore important for the purpose of starting adequate therapy as quickly as
      possible and preventing the rise and establishment of those lesions which
      condition an irreversible trend of the clinical condition. In this note the means
      today available for early diagnosis fo fistula, with particular reference to
      early radiological examination, are discussed. Early diagnosis and adequate
      prompt treatment may, in our opinion, lead to an improvement in the poor results
      reported by a number of surgical schools.

PMID- 1029524
TI  - [The Budd-Chiari syndrome: clinical case reports].
AB  - Two cases of Budd-Chiari's Syndrome are presented. These refer to two women aged
      34 and 33 years respectively. The aetiology of the first case is linked to
      polycythaemia rubra and the use of oral contraceptives; that of the second case
      to a fibrous perihepatitis involving the outlet of the suprahepatic veins, with a
      tenacious action of stenosis. The surgical therapy used was a latero-terminal
      left porto-renal shunt in the first case, and a decapsulation and ligature of the
      common hepatic artery in the second case. In the discussion the
      aetiopathogenetic, diagnostic and therapeutic problems inherent in the Syndrome
      are analysed, also on the basis of the most recent experiences reported in the
      relevant literature.

PMID- 1029526
TI  - [Recent aspects of pulmonary tuberculosis in thoracic surgery].
AB  - Pulmonary tuberculosis--although appreciable reduced as regards number of cases-
      is still far from being wiped out and even today constitutes a real problem in
      the field of thoracico-pulmonary surgical pathology. Infection with Koch's
      bacillus can from this point of view arise basically according to two procedures:
      a) as superimposed element--unexpected guest--on a pulmonary disease of surgical
      interest, sometimes being mistaken for it (e.g. a tubercular inflammation of slow
      evolution mistaken for a cancer of the lung) or b) taking the form of pulmonary
      relics of an earlier and apparently extinguished Kochian infection, the starting
      point of an always possible revival of the infection during the postoperative
      period. In the former case the so-called attack therapy must be adopted without
      delay in accordance with well tested doses and schedules; in the latter case by
      means of a chemoprophylaxis, carried out in with rifampicin (600/1200 mg/day) in
      the cases reported and also continued in the postoperative period.

PMID- 1029527
TI  - [Mammary biopsy with a needle-drill: indications, technic, results].

PMID- 1029528
TI  - [Indications and limitations of bronchography in surgery of carcinoma of the
      lung].
AB  - Starting from a consecutive series of 53 bronchographies performed under local
      anesthesia, in subjects with carcinoma of the lung ascertained by operation, the
      Authors analyse both the bronchographical aspects which most frequently come
      under the surgeon's observation, and the usefulness of this investigation in
      formulating the operating plan. As regards carcinomas of the large and medium
      bronchi, the bronchographic aspects they found most frequently are occlusion
      (82%) both in the form of sudden arrest and in the form of a cone image and
      stenosis (18%). In peripheral carcinomas, on the other hand, most characteristic
      bronchographic signs are identified as occlusion (58%) (amputation and stenosis)
      and dislocation (38%) with rigidity of one or more small calibre bronchi (rigid
      impairment). On the basis of their experience the Authors conclude that
      bronchography constitutes an almost indispensable examination for diagnostic
      purposes in malignant neoplasias, especially in the initial stage, when located
      outside the field of action of bronchoscopy, and can supply elements
      indispensable in the preoperative operatability judgement. In fact it not only
      gives very reliable information on the anatomical situation of the bronchus, as
      well as on the site and presumed starting-point of the neoplasia, but also
      supplies more approximate elements with regard to the extent of the neoplasia and
      any presence of lymphoglandular metastases.

PMID- 1029529
TI  - [Emergency surgical treatment of diverticular disease of the colon (personal
      cases and review)].
AB  - After a critical review of the indications, techniques and results recorded in
      literature, there is a description of experiences in emergency surgical treatment
      of 24 cases of diverticulum disease of the colon. In the light of personal
      results and in agreement with the majority of cases reported in literature, the
      conviction is expressed that in this surgery the processes graduated in stages
      (Mickulicz, Hartman, colostomy on transverse - resection) may frequently be
      indicated, especially in serious and weak patients.

PMID- 1029530
TI  - [Primary malignant neoplasms of the duodenum. Considerations on 4 cases].
AB  - Starting from four primitive malignant neoplasias of the duodenum observed during
      the course of the last two years, the Authors briefly outline the clinical
      aetiopathological and especially the radiological characteristics of duodenal
      primitive malignant neoplasias. They stress the importance of the radiological
      investigation for early diagnosis of such disturbances, as can clearly by deduced
      from illustration of the radiological pictures concerning the four cases, all
      male patients aged from 55 to 68 years. A localisation in the duodenal bulb, with
      ulceration, is to be considered very rare; the other localisations were two at
      the 2nd and one at the 1st duodenal portion.

PMID- 1029531
TI  - [Revascularization of the aorto-femoral axis by means of a by-pass. Remote
      results].
AB  - The Authors report their experience in 73 patients wit aorto-iliaco-femoral
      chronic obliteration, subjected to revascularisation. In 49 cases a bilateral by
      pass was performed, in 22 a monolateral by-pass, and in two a
      thromboendarterioectomy. The results obtained were classified as successes or
      failures according to the perviousness or otherwise of the substituted or
      disobliterated arterial segments, and as immediate or longterm according to
      whether they were evaluated at the time of the patient's discharge or during a
      period lying betwee six months and seven years from the operation. Immediate
      successes were obtained in 95.9% of cases with bilateral by-pass, and in 90.9% of
      the monolateral by-passes. Aggregate mortality was 2.7%. In the long-term chick
      ups, the previousness of the bilateral by-passes was 82.9%, that of the
      monolateral by-passes 72.2%. On the basis of the results obtained the Authors
      therfore reiterate their preference for by-passes, and for bilateral by-passes in
      particular (70% of cases). Monolateral bridging were in fact performed only in
      those cases where the contralateral vascular district was unharmed, in patients
      with serious ganrenous lesions and those with a high operative risk.

PMID- 1029532
TI  - [Pathogenetic and clinico-diagnostic considerations on a case of non-parasitic
      cyst of the spleen].
AB  - A rare case of non-parasitic cyst of endothelial type, recently observed in the
      spleen, is illustrated. The relevant literature is reviewed, Fowler's
      classification stressed, and the aetiopathogenetic and histopathological
      characteristics of such cysts are discussed in critical spirit. The diagnostic
      means are also fully described. With stress on the utility of the scintiscanning
      examination.

PMID- 1029533
TI  - [Bifid ureter with a blind-ending segment. (2 personal cases)].

PMID- 1029534
TI  - [Soft calculosis of the kidney].

PMID- 1029535
TI  - [Problems of anesthesia and resuscitation in drepanocytic anemia].
AB  - A study was made of anesthesiological and resuscitation problems in 18 patients
      suffering from drepanocytic anemia. An examination of the results showed that the
      anesthesiological problems do not so much concern selection of the anesthetic as
      a knowledge of the physiopathology of this disease, i.e. the tendency to
      bronchopulmonary complications as a result of the increased viscosity of the
      blood, the increased mechanical fragility of the erythrocytes, and erythrostasis,
      with consequent rise of ischaemic necrosis and damage to the various parenchymas.
      It was also observed that pulmonary complications occurred more frequently in
      preoperatively transfused patients.

PMID- 1029536
TI  - [Renal resistance in ethrane anesthesia].
AB  - The indices of renal functionality are studied during the course of ether
      anesthesia in order to ascertain the behaviour of the kidney subjected to
      narcosis with this drug. A sharp reduction in the minute volume of F.G. and
      P.R.E. is evidenced, together with an increase in renal resistances, especially
      as regards the efferent sector. These changes, which are established at the start
      of anesthesiological treatment, tend to decrease in intensity as narcosis
      continues. This picture is interpreted as being due to the concomitant action of
      two factors: a decrease in cardiac output on the one hand, and an increased
      incretion of catecholamines leading to renal arteriolar vasoconstriction on the
      other.

PMID- 1029537
TI  - [Circulatory flow during anesthesia with enflurane].
AB  - The rebreathing technique was used to study the behaviour of the circulatory flow
      in patients operated under ether anesthesia. It was observed that during ether
      narcosis the circulatory flow values show a fair drop at the readings made 30'
      and 45' after the inductive period. 60' after the start of ether narcosis the
      circulatory flow values show a tendency to increase, and these observations are
      accentuated in the readings taken at 75' and 90'.

PMID- 1029538
TI  - [Principles of treatment of patients with multiple injuries].
AB  - Treatment of the seriously multi-traumatised patient in accordance with the
      principles in use at the Unfallkrankenhaus at Linz is illustrated. The different
      moments of the diagnostic and therapeutic measures, the main aim of which must be
      the re-establishment of the vital functions (respiration and circulation), are
      indicated. The article gives diagrams of the classes of priority of the urgent
      measures to be undertaken in the multi-traumatised patient, drawing attention to
      all the devices of modern resuscitation. In conclusion there are some
      observations on organisation of collection of serious multi-traumatised cases.

PMID- 1029539
TI  - [Injurious action of ultrasonics].
AB  - It was felt to be advisable to insist on the harmful action of ultrasounds, since
      their use in the field of medical therapy is relatively recent and, after causing
      exaggerated enthusiasm, they now appear to be relagated to the rank of useless
      accessories. The truth is more tempered and this physical agent must be numbered
      among the most interesting ones, provided that the technique of its application
      is perfect and that account is taken of the possibility of incidents or accidents
      which can be caused by incomplete knowledge thereof.

PMID- 1029540
TI  - [Traumatic hypovolemic shock].
AB  - The physiopathological aspects of traumatic hypovolemic shock (T.H.S.) are
      described. On the basis of clinical and biochemical diagnostics, suitable T.H.S.
      resuscitation and therapeutic measures can be undertaken. The principles of
      treatment of T.H.S., as applied at the U.K.H. of Linz are then set out. Intense
      cooperation between anesthetist and traumatologist, as shown by this short note,
      is the clearest demonstration of what medicine can do today in the field of
      traumatology.

PMID- 1029541
TI  - [Subcutaneous rupture of the extensor tendon of the fingers and its treatment].
AB  - The process used in 47 cases for treatment of subcutaneous rupture of the
      extensor tendon at the level of the third phalanx is described. This process of
      mixed type consists in making a temporary fixation of the third phalanx in slight
      extension on the second by means of the endomedullary infibulum, to which is
      added a plaster guardian with 60 degrees flexion of the interphalangeal for six
      weeks. After illustration of the method, a full set of cases is presented in
      demonstration of the perfect efficiency of the method through the good results
      obtained.

PMID- 1029542
TI  - [Betamethasone acetate in the therapy of epicondylitis].
AB  - The advantages of cortisone therapy in the particular pathology of the elbow are
      evaluated, with special reference to humeral epicondylitis. After an outline of
      the mechanism of action of steroids, consideration is given to the advantages
      arising from use of a delayed action cortisone product. Reference is made to the
      relevant literature on the subject, together with a report on personal cases.

PMID- 1029543
TI  - [Compression of the posterior branch of the radial nerve].
AB  - Some compressions of the posterior branch of the radial nerve (posterior
      interosseous nerve) may be caused either by transverse fibrous formations in the
      front of the articular capsule of the elbow or by the anterior edge of the 2nd
      radial, as well as by Froshe's arch or the surface end ot the short supinator.
      Such damage may be due to repeated dorsal bending movements of the wrist,
      hyperextension of the elbow and, above all, pronosupination of the forearm.

PMID- 1029544
TI  - [Hydatid cyst of the orbit. Discussion of 2 cases].

PMID- 1029545
TI  - [Isotope examination of the lacrimal duct. Preliminary study].

PMID- 1029546
TI  - [A case of scleromalacia perforans. Diagnostic and therapeutic problems].

PMID- 1029547
TI  - [A preliminary communication on the problem of cyclophoria and ocular
      torticollis].

PMID- 1029548
TI  - [2 cases of metallic foreign bodies in the crystalline lens].

PMID- 1029549
TI  - [Marfan's syndrome (apropos of 71 cases)].

PMID- 1029550
TI  - [Sjogren-Larsson syndrome with Stardgardt's juvenile macular degeneration].

PMID- 1029551
TI  - [Bilateral dysplastic total retinal detachment with microphthalmia. Discussion of
      the clinical value of associated hydrocephalus].

PMID- 1029552
TI  - [Unilateral temporal hemianoptic scotoma caused by a hypophyseal tumor (apropos
      of a case)].

PMID- 1029553
TI  - [Fistulizing trabeculectomy beneath the scleral flap. A) A case of postoperative
      degeneration of the scleral flap and its floor. B) Surgical technic in the
      attempt to change the tension results].

PMID- 1029554
TI  - [Influence of body posture on ocular pressure and intraocular pulsation
      (measurements with the pneumonotonograph)].

PMID- 1029555
TI  - [Kearns' syndrome].

PMID- 1029556
TI  - [Influence of tobacco smoke on the pressure of the central retinal artery].

PMID- 1029557
TI  - [The place of cyclocryotherapy in the treatment of glaucoma].

PMID- 1029558
TI  - [A case of Wegener's granulomatosis with orbital involvement].

PMID- 1029559
TI  - [Diagnostic problems posed by Coats' retinopathy].

PMID- 1029560
TI  - [Retinal artery aneurysms].

PMID- 1029561
TI  - [Development and prognosis of subretinal hemorrhage].

PMID- 1029562
TI  - [The value of infrared angiography with indocyanine green in the clinical
      diagnosis of angiomas of the choroid (anatomo-clinical report)].

PMID- 1029563
TI  - [Clinical evaluation of a 0.5% epinephrine-pilocarpine combination].

PMID- 1029564
TI  - [Perforation on contact lenses].

PMID- 1029565
TI  - [Cryocoagulation of iris hernia occurring after cataract surgery].

PMID- 1029566
TI  - [Ophthalmologic translation of tumors of the orbital cavity].

PMID- 1029567
TI  - [Benign epithelioma of the ciliary body diagnosed after cyclectomy].

PMID- 1029568
TI  - [Appearance of traumatic retinal detachment caused by vitreous stress].

PMID- 1029569
TI  - [Stargardt's incipient flavimaculatus disease (apropos of 2 cases of pure fundus
      flavimaculatus)].

PMID- 1029570
TI  - [Tentative classification of electroretinographic changes].

PMID- 1029571
TI  - [Surgical treatment of congenital cataract using the double-current method. Film
      (16mm)].

PMID- 1029572
TI  - A case of familial congenital paralysis of the large oblique muscle.

PMID- 1029573
TI  - [Experimental trabeculotomy with the monomode argon laser].

PMID- 1029574
TI  - [Congenital glaucoma and trabeculectomy].

PMID- 1029575
TI  - [Tissue groups and ophthalmology].

PMID- 1029576
TI  - [Practical importance of tissue grouping in uveitis].

PMID- 1029577
TI  - [Treatment of angiomas with radiotherapy].

PMID- 1029578
TI  - [Muco-epidermoid carcinoma of the limbus].

PMID- 1029579
TI  - [When should rubella cataract be operated on ?].

PMID- 1029580
TI  - [Vascularization of the lacrimal gland: normal radiological anatomy].

PMID- 1029581
TI  - [Structural study of retinoschisis].

PMID- 1029582
TI  - [Attempted angiographic classification of papillary neovascularizations.
      Prognostic value].

PMID- 1029583
TI  - [Retinal tear appearing after photocoagulation. Apropos of a case].

PMID- 1029584
TI  - [Peters syndrome and extensive colobomatous dysmorphia].

PMID- 1029585
TI  - [Serious ocular and palpebral manifestations of allergic origin].

PMID- 1029586
TI  - [Etiological diagnosis of uveitis and therapeutic management].

PMID- 1029587
TI  - [Extramacular central serous chorioretinopathy associated with supposed
      histoplasmic choroiditis (case report)].

PMID- 1029588
TI  - [Functional damage in initial diabetic retinopathy].

PMID- 1029589
TI  - [The retinal periphery of aphakic subjects].

PMID- 1029590
TI  - [A rarely used surgical technic for treatment of lower eyelid trichiasis].

PMID- 1029591
TI  - [Placoid pigment epithelopathy or choriocapillaritis. Clinical aspect and fluoro
      angiographic development in relation to treatment with corticoids].

PMID- 1029592
TI  - [Attempted pathogenic interpretation of oculomotor disorders of concomitant
      strabismus].

PMID- 1029593
TI  - [Electrooculographic study of oculomotor disquilibrium].

PMID- 1029594
TI  - [Strabismus and dyslexia].

PMID- 1029595
TI  - [Analysis of handicap (penalization) treatments in the amblyopic and strabismic
      young child].

PMID- 1029596
TI  - [Efficacy of the right-left bascule in the treatment of strabismus. Physiologic
      basis].

PMID- 1029597
TI  - [Application of binary classification to the study of strabismus. Its value in
      practice and in research].

PMID- 1029598
TI  - [Possibilities of functional reeducation in microstrabismus with excentric
      fixation].

PMID- 1029599
TI  - [The thread operation].

PMID- 1029600
TI  - [Three years' experience with Cuppers' thread operation in operations for
      esotropia with the phenomenon of innervation block].

PMID- 1029601
TI  - [Psychogenic strabismus and spasmodic strabismus].

PMID- 1029602
TI  - [Aniseikonia responsible for poor fusion?].

PMID- 1029603
TI  - [Postoperative 'strabismus' after surgery for retinal detachment].

PMID- 1029604
TI  - [Relative value of procedures for weakening the small oblique muscle body].

PMID- 1029605
TI  - [Vertical deviations in convergent strabismus and their treatment].

PMID- 1029606
TI  - [The relationship between the eye and various skin diseases].

PMID- 1029607
TI  - [Basal cell epithelioma of the eyelid in ichthyosis].

PMID- 1029608
TI  - [Two familial cases of xeroderma pigmentosum].

PMID- 1029609
TI  - [Trial treatment with levamisole of recurrent corneal viral diseases].

PMID- 1029610
TI  - [Oculocutaneous polydysplasic syndrome].

PMID- 1029611
TI  - [Technical photographic data in fluorescence of the macular region].

PMID- 1029612
TI  - [Adamantiades-Behcet syndrome. Current concepts].

PMID- 1029613
TI  - [Two cases of Werner's syndrome].

PMID- 1029614
TI  - [The use of flickering light in the functional study of the macula].

PMID- 1029615
TI  - [Cutaneous hypopigmentation and ocular diseases].

PMID- 1029616
TI  - [Pars plana approach to the lens].

PMID- 1029617
TI  - [The therapeutic trap of virosis changing in clinical pattern to corneal
      allergy].

PMID- 1029618
TI  - [Mesodermal dysgenesis of the iris and the cornea apropos of ten cases].

PMID- 1029619
TI  - [Cataract and Binkhorst implant].

PMID- 1029620
TI  - [Thrombosis of the central vein of the retina during anticoagulant treatment].

PMID- 1029621
TI  - [Glaucoma and uveal pseudo-exfoliation. Research on the ultrastructure of the
      trabeculum and the iris].

PMID- 1029622
TI  - [Aeronautic and space ophthalmology].

PMID- 1029623
TI  - [The Chauvin Prize lecture: Normal and pathologic corneal endothelium].

PMID- 1029624
TI  - [The French Society of Ophthalmology. General Assembly of 8 May 1976. 82nd
      Congress. Closing address].

PMID- 1029625
TI  - [Functional profiles in serious detachments of the macula. Cystoid edemas and
      premacular fibroses. Comparative findings].

PMID- 1029626
TI  - [Inflammatory diseases of the macula].

PMID- 1029627
TI  - [Postoperative macular edema].

PMID- 1029628
TI  - [Anatomo-pathological aspects of disciform degenerations of the macula].

PMID- 1029629
TI  - [The macula].

PMID- 1029630
TI  - [Research on phospholipids of the retina and their therapeutic use in cases of
      maculopathy].

PMID- 1029631
TI  - [Therapeutic methods in macular diseases].

PMID- 1029632
TI  - [Medical treatment of macular diseases by enzyme inhibitors].

PMID- 1029633
TI  - [Macular changes in the development of angiomatoses under treatment].

PMID- 1029634
TI  - [Ocular biometry and heredity of the Weill-Marchesani syndrome].

PMID- 1029635
TI  - Myoclonic disorders of spinal origin.
AB  - Data in the literature on spinal myoclonic disorders are still scanty; little has
      been done to ensure an adequate classification; little is known about the
      pathophysiology of these disorders. Three patients with spinal myoclonic jerks
      are described, with detailed reference to electromyographic findings. On the
      basis of the case reports so far available, a classification into five subgroups
      is suggested of spinal myoclonic jerks: 1) after cord injuries; 2) associated
      with intramedullary cord tumours; 3) associated with intramedullary or
      extramedullary cysts; 4) associated with radiculomyelitis or myelopathy; 5)
      associated with affections of the alpha motoneurons. A number of hypotheses on
      the pathogenesis of this disorder are briefly discussed: peripheral or
      intraspinal sprouting, degeneration of alpha motoneurons or interneurons,
      reduction of the dendritic tree size, and involvement of the gamma system.

PMID- 1029636
TI  - Torkildsen's ventriculocisternostomy: some complications and their prevention.
AB  - Torkildsen's ventriculocisternostomy retains a certain usefulness despite the
      recent popularity of newer procedures. Despite many modifications and suggestions
      for improving the procedure, certain hazards and complications remain. We report
      instances of myelopathy from contact with and impalement by the cervical end of
      the tube, acute quadriplegia, unsuspected kinking of the catheter and late
      ventricular catheter malposition together with certain suggestions for
      modifications of technique which we believe will make Torkildsen's shunting more
      reliable and safe.

PMID- 1029637
TI  - Further observation on the possible relationship between migraine and serum
      ammonia levels.
AB  - Although patients diagnosed as having migraine, have been studied extensively,
      there is no definite proof of a primary biochemical abnormality which is of
      significance in the pathogenesis of migraine. Several authors have suggested that
      increased serum ammonia levels may play a decisive role in the pathogenesis of
      migraine. This possibility was first put forth by Russell, who studied a single
      family with ornithine carbamyl transferase deficiency and 8 juveniles with
      migraine, RUSSELL'S finding was supported by a preliminary study carried out by
      one of the authors in which hyperammo-naemia was found in 22 adults during
      migraine attacks. In order to etknd these earlier findings, serum ammonia levels
      were determined in 35 adults with either classic or complicated migraine and in
      20 healthy adults. No significant difference was found between the patients (44
      microgram/100 ml +/- 13.9) and the controls (74 microgram/100 ml +/- 9.5).
      Ammonia level was determined in 10 patients within two hours of the onset of an
      acute migraine and was unchanged (65 microgram/100 ml). This study suggests that
      alterations in serum ammonia level are not important in the pathogenesis of
      migraine in adults.

PMID- 1029638
TI  - Differential effects of simple and choice reaction after closed head injury.
AB  - Simple and choice reaction time to visual signals were recorded in persons having
      sustained a closed head injury. The results show a disproportional effect of task
      complexity in comparison to the performance of a normal group. Moreover, an
      interaction was demonstrated between complexity of the reaction task and length
      of coma after the injury. Finally it was shown that this interaction was still
      visible 22 months after the concussion. At that time, there is no longer a
      difference in simple reaction time between groups with different lengths of coma,
      while there is still a significant difference in the choice reaction task.

PMID- 1029639
TI  - Effect of moderate arterial hypotension combined with repeated withdrawal of
      cerebrospinal fluid on the development of increased ventricular fluid pressure
      after cold injuries in cats.
AB  - The influence of Trimetaphan induced hypotension was studied on the development
      of increased ventricular fluid pressure after induction of cold injuries of the
      brain in cats. Hypotension was induced in two series of animals: in one
      immediately after freezing and in another series after a delay of three quarters
      of an hour. In the animals not treated with hypotension ventricular fluid
      pressure increased considerably according to three types of response. In both
      series treated with hypotension the ventricular fluid pressure and elastance were
      significantly lower than in the animals not treated; also brain stem herniation
      tended to occur less frequently in the animals treated. No deleterious effect of
      the hypotension was seen on cerebral metabolism as measured by the lactate
      content in the cerebrospinal fluid.

PMID- 1029640
TI  - Model role for bacteriorhodopsin for solar energy utilization by primordial
      organisms.
AB  - Enzymes similar in function to contemporary bacteriorhodopsin could have been
      active in primordial living organisms for the utilization of solar energy to
      produce ATP. The energy-conversion system, which depends on a light-driven proton
      pump, is enzymatically simple, insensitive to cyanide inhibition and functional
      under highly lipid conditions in an anaerobic atmosphere.

PMID- 1029641
TI  - Electron microscopic study of the differentiation and development of trophocytes
      and oocytes in Gerris najas (Heteroptera).
AB  - The differentiation of oogonia and oocytes, and of trophocytes, from
      undifferentiated germ line cells has been studied in Gerris najas, a pond skater,
      from the fourth instar to the adult animal. For the first time criteria have been
      obtained which allow the distinction between poorly differentiated early oogonia
      and nurse cells. The most important criteria are the size, shape, and structure
      of nuclei and mucleoli. This is consistent with the different function of these
      cell types, which is primarily a different nuclear function: meiosis in the
      oocytes, and RNA synthesis to support the trophic core and the oocytes in the
      trophocytes.

PMID- 1029642
TI  - Electron microscopic study of concanavalin A binding to membranes of the Golgi
      complex.
AB  - Binding of Concanavalin A to the Golgi complex and the resultant effect on
      intramembrane particles and enzyme activity has been studied with Golgi-rich
      fractions isolated from rat liver. Con A binds mainly to the tubular network of
      the Golgi complex and, to a lesser extent, the peripheral regions of the
      cisternae. Interaction of Con A with Golgi membranes is accompanied by
      aggregation of intramembrane particles reflecting increased membrane fluidity.
      Enhancement of galactosyl transferase, membrane bound in the Golgi complex, also
      occurs with Con A binding.

PMID- 1029643
TI  - Histological study of the effects of hycanthone on the frog's ventricle in the
      presence of a soluble sodium salt of prednisolone hemisuccinate.
AB  - The histological picture of the ventricle of frog's heart exposed to the action
      of Hycanthone in Ringer's solution in concentration of 1:1 was compared with that
      of the ventricle of frog's heart exposed to Ringer's solution devoid of the drug
      and with that of frog's heart exposed to Ringer's solution containing Hycanthone
      in concentration of 1:1 in addition to a soluble sodium salt of prednisolone
      hemisuccinate in concentration 1:1. It was found that the structure of the
      ventricle of the heart exposed to the action of Hycanthone in the presence of the
      soluble sodium salt of prednisolone hemisuccinate was close in pattern to the
      structure of the ventricle of the heart exposed to Ringer's solution alone, while
      the ventricle of the heart exposed to Hycanthone alone in Ringer's solution in
      concentration of 1:1 was different in that the muscle fibres swollen, the
      cytoplasm was paler with less marked striations, the nuclei were swollen and
      paler, the epicardial cells were swollen and the connective tissue pattern was
      distorted. This denoted that the morphological changes that occurred in response
      to Hycanthone in the presence of the soluble sodium salt of prednisolone
      hemisuccinate was less marked than those which occurred in its absence.

PMID- 1029644
TI  - Hycanthone in the treatment of Egyptian bilharzial patients.
AB  - Hycanthone has a schistosomicidal effect against S. haematobium and S. mansoni
      present singly or combined in the patient. It is effective in all age groups but
      better in old and adults than in children and better in females than in males. It
      gave a cure rate of 60.6% after single intramuscular dose of 3 mg/kg body weight.
      Second dose after three months gave 94.4% cure rate and a third injection after
      further two months gave 100% cure rate. So, the drug cannot be used in the
      treatment of bilharziasis as a single dose course.

PMID- 1029645
TI  - The chemistry of schistosomicides.
AB  - The chemistry of the different compounds applied in the field of schistosomicides
      has been reviewed in detail. On the basis of their chemical constitution, these
      compounds have been classified into: organotrivalent antimonials; Xanthones and
      related compounds "xanthones, chromones and mirasans"; Nitroheterocyclic
      compounds "nitroquinolines, nitrofurans and nitrothiazoles"; Miscellaneous
      compounds "phenoxy compounds, piperazines, naphthylazo compounds, phosphorous
      compounds, carbanilides, rosanilines, salicyclic acid derivatives and natural
      products". On consideration of biochemical and pharmacological investigations,
      studies concerned with mechanism of action, metabolic changes and comparative
      toxic effects of some groups of these compounds are reported. Investigations on
      the relation between constitution and action among variety of these compounds are
      included.

PMID- 1029646
TI  - Bilharziasis of the central nervous system in human beings and experimental
      animals.
AB  - The investigator studied schistosomiasis of central nervous system in human
      cadavers and hamsters. He found out that 13.3% of the spinal cords of the human
      cadavers were infected by Schistosoma ova. The lesion was confined to the
      lumbosacral region of the cord in cases of advanced bilharziasis. The cords of
      infected Hamsters showed only diffuse cell infilterate without ova. The possible
      pathways of ova from the final habitats of the parasites to the cord are
      pelvivertebral and portovertebral connections as shown from the discovered
      pathological changes in the blood vessels of these areas.

PMID- 1029647
TI  - The structure of tartar-emetic.
AB  - Evaluation of the validity of the different formulae assigned to tarar-emetic is
      reviewed. According to the recent and most valid structure, tartar emetic is
      defined as potassium hydroxytartratoantimonite hemihydrate which is a derivative
      of the antimonite ion [Sb(OH)4]-.

PMID- 1029648
TI  - Influence of diet on breeding and infectivity in mass cultivation of Biomphalaria
      glabrata.
AB  - Under well defined laboratory conditions as troughs, room temperature, humidity,
      water and air supply Biomphalaria glabrata was bred and kept. In  feeding trials
      powder of pellets for mice and commercial fish food were used as high protein
      diet in comparison to poor protein diet consisting of lettuce only. The high
      protein diet resulted in more clutches and eggs per snail than the lettuce diet.
      Also the yield of cercariae in the rish protein group was much higher than in the
      group fed on on lettuce alone. The optimal amount of snails could be obtained by
      feeding pellet powder, fish food and lettuce.

PMID- 1029649
TI  - Influence of diet on breeding and infectivity in mass cultivation of Bulinus
      truncatus.
AB  - Under well defined laboratory conditions as troughs, room temperature, humidity,
      water, and air supply Bulinus truncatus was bred and kept. In a feeding trial
      high protein diet consisting of powdered mice pellets, commercial tropical fish
      food and lettuce was compared to poor protein diet of lettuce alone. Higher yield
      of clutches, eggs and cercariae were observed in the rich protein diet group,
      Bulinus and Biomphalaria Snail seem to be influenced by diet in the same way.

PMID- 1029650
TI  - Stereo-scan observations on the cercaria of Schistosoma haematobium.
AB  - The scanning electron microscope was employed to observe the hinge region and
      excretory canal of the cercaria of Schistosoma haematobium.

PMID- 1029651
TI  - Assessment of left ventricular function in schistosomiasis.
AB  - Inspite of the fact that the haemodynamic changes in the right ventricle in
      schistosomal disease received proper attention, left ventricular changes were not
      equally assessed. That the left ventricle could suffer in bilharzial disease is a
      possibility, probably due to the development of shunts and toxic myocarditis. In
      this wor5, left ventricular functions were studied using the rate of maximum rise
      of intraventricular pressure (kp/dt) as an index of contractility. The study
      included 10 normal controls, 5 cases with bilharzial liver fibrosis and no
      ascites or cor pulmonale, 10 cases with BLF, and ascites but no cor pulmonale,
      and 10 cases with bilharzial cor pulmonale. Diminished dp/dt values were obtained
      in 8 out of the 10 cases of bilharzial cor pulmonale, in whom the left
      ventricular pressure curve also showed distortion and delay in the descending
      limb of the isometric relaxation phase, denoting defective contractility of the
      left ventricle, and probably a diastolic volume overload in these cases. In BLF
      with or without ascites, the dp/dt values were surprisingly increased possibly
      due to increased catecholamines in these cases secondary to ineffective
      destruction in the liver suffering from parenchymatous disease. The left
      ventricle is thus shown to suffer in bilharzial disease particularly in cases
      with bilharzial cor pulmonale.

PMID- 1029652
TI  - The effects of dyphylline [7-(2,3-dihydroxypropyl) theophylline] on the toxicity
      of hycanthone on the frog's heart.
AB  - The effects of the topical application of Dyphylline in concentrations of 1.0
      mg/1.0 ml and 10 mg/1.0 ml Ringer's solution and 25 mg/1.0 ml, 0.065% NaCl
      solution (the content of ampoules in clinical use) were investigated on frog's
      heart in situ. Dyphylline in all of the above concentrations had a stimulatory
      effect on the frog's heart. Hycanthone methanesulphonate in concentration of 1.0
      ml/1.0 ml when topically applied to the frog's heart had a depressant effect on
      both of the contractility and rhythmicity. The depressant effects of Hycanthone
      in concentration of 1:1 were compared before and after the topical application of
      Dyphylline in the above mentioned concentrations. It was found that Dyphylline in
      concentration of 1.0 mg/1.0 ml could partially antagonize the depressant effect
      of Hycanthone on the heart rate but not on the force of contraction. Dyphylline
      in concentration of 10 mg/1.0 ml could partially antagonize the depressant
      effects of Hycanthone on both of the heart rate and the force of contraction.
      Dyphylline in concentration of 25 mg/1.0 ml could completely antagonize the
      depressant effects of hycanthone on both of the heart rate and the force of
      contraction.

PMID- 1029653
TI  - Clinical features and treatment of urinary calculi in childhood.
AB  - During the period 1926-1975, 94 children with urinary calculi were treated. The
      incidence, causation, localisation, symptomatology and diagnosis of urolithiasis
      in children are discussed. The therapeutic possibilities are also outlined.
      Particular emphasis is laid on therapeutic programmes for the prevention of
      recurrence in all varieties of urinary calculi, by means of which the recurrence
      rate in our own series was reduced to around 16%.

PMID- 1029654
TI  - Renal cell carcinoma--invasion of veins.
AB  - Out of 188 operatively removed renal cell carcinomas 49% showed macroscopic
      evidence of vein invasion and in 28% of the cases only histologically provable
      vein invasion. The uncorrected 5-year survival rates amounted to 40.8% in
      macroscopic vein invasion, 60.6% in histologically provable vein invasion and
      75.6% in the absence of vein invasion. The term 'vein invasion' should therefore
      always be defined more precisely. Hence suggest to modify the V classification of
      1974 of the UICC.

PMID- 1029655
TI  - Influence of plastic splints in the production of epithelial tubes from buried
      skin strips. An experimental study.
AB  - Based on the practice of the Browne technique for hypospadias, epithelial skin
      strips were splinted with polyvinyl tubes. In an experimental study the well
      known excellent tissue tolerance of the polyvinyl material was demonstrated.
      Definite enlarged diameter of the splinted epithelialized tubes was observed in
      comparing it with unsplinted controls.

PMID- 1029656
TI  - Acute retention of urine due to prolapsed ectopic ureterocele in an adult male.
AB  - A case is presented of prolapsed ectopic ureterocele which produced severe
      urinary retention in a 31-year-old male patient. The usefulness of lumbar
      transcutaneous puncture is emphasized in a case associated with a non-functioning
      upper pole of a duplex kidney.

PMID- 1029657
TI  - [Results of 8 years' research on the toxicologic evaluation of animal food
      additives by the so-called relay toxicity method].
AB  - The authors report the underlying principles of the new methodological approach
      called "relay toxicity" which they proposed eight years ago for the toxicological
      evaluation of animal feed additives. They stress its value either as a possible
      criterion of rejection or as a criterion of acceptability. In the latter case,
      the limiting factor is the difficulty of applying an adequate safety factor when
      food products destined for human consumption and obtained from animals receiving
      the additives to be evaluated are administered to laboratory animals. Amongst the
      examples of the additives which have been subjected to toxicological evaluation
      using the authors' new method, the following are examined: as growth factor,
      carbadox, anabolising agents and, in particular, diethylstilboestrol, and
      steroids used as egglaying potentializers. The results obtained are discussed.

PMID- 1029658
TI  - [Determination of lead in foodstuffs and tobacco].
AB  - A large variety of food containing lead, food is for us an important source of
      contamination. The average quantity of lead contained in food and tobacco has
      been established yet. Thanks to these results, we known the exact quantity
      absorbed by men in normal conditions of living. We are working to establish its
      dosage with atomic absorption spectrophotometry.

PMID- 1029659
TI  - [Effect of subacute fluorine poisoning in the rabbit on fluorine and phosphorus
      calcium metabolism and on radiography of the skeleton].
AB  - Rabbit subacute fluoride intoxication effects (21,4 mg a day for 10 months) are
      researched on fluor, calcium and phosphorus metabolism and on skeletal radiology.
      Fluoremy increase (p less than 0.05) and there is a strong fluor retention (p
      less than 0.01), due to fluor digestive utilization coefficient increase (p less
      than 0.05), in spite of relative hyperfluorury (p less than 0.05). Calcemy
      decreases (p less than 0.01), but phosphatemy and alkaline phosphatasemy do not
      vary but a little. Calcium and phosphorus balances become negative (p less than
      0.05), due to calcium digestive utilization coefficient inversion (p less than
      0.05) and phosphorus digestive utilization coefficient decrease (p less than
      0.05) and hypercalciury (p less than 0.05) and hyperphosphatury (p less than
      0.05) with phosphorus renal reabsorption coefficient decrease (p less than 0.05).
      Some skeletal radiological abnormalities appear on rachis and limbs.

PMID- 1029660
TI  - [Risks of mercury poisoning in the dental laboratory].
AB  - We present the results of an inquiry about the hydrargyric risk run by the staff
      of an odonto-stomatological laboratory. A second laboratory in which mercury was
      not used, served as a control. It would appear that the staff in the laboratory
      where the practician uses amalgam have a level of mercury higher than that of the
      staff working in the control laboratory. This level reaches the maximum in the
      middle of the day and returns to the same level as that of the controls after the
      nights rest outside the polluted atmosphere. These results are discussed in the
      light of our findings and of facts obtained from literature.

PMID- 1029661
TI  - [A new synthesis of delta 9-tetrahydrocannabinol].
AB  - The authors effected the synthesis of delta9-tetrahydrocannabinol (delta9-THC) by
      first preparing the raw materials: olivetol and p-menthadiene-2.8 ol-1. Then
      these two reactants were put into contact in the presence of p-toluene sulphonic
      acid to give the isomer delta8-THC which was converted into the isomer delta9
      THC.

PMID- 1029662
TI  - Antigens of chemically induced tumors.

PMID- 1029663
TI  - On the nature of tumour-specific transplantation-type antigens.

PMID- 1029664
TI  - Role of complement components on cells and in cell interactions.
AB  - The complement system, though complex, is relatively easy to study both in terms
      of its reaction pathways, its distribution and its genetics. There is reason to
      believe that the complement system is involved in cell surface events and
      interactions at a variety of levels and we may hope that the knowledge of the
      system in the blood plasma will provide relatively easy insights into the more
      difficult areas with cells.

PMID- 1029665
TI  - Cell-coat glycosaminoglycans in cellular transformation and differentiation.

PMID- 1029666
TI  - Human graafian follicles in tissue culture: correlations between oestrogen and
      progesterone production and the site of delta5-3beta-hydroxysteroid dehydrogenase
      activity.

PMID- 1029667
TI  - Immunization of ewes to oestrogens: effects on the oestrous cycle and
      parturition.

PMID- 1029668
TI  - Local application of prostaglandin F2alpha to the exterior of the ovarian
      vasculature: effects on the ovine corpus luteum.

PMID- 1029669
TI  - Prostaglandins and luteolysis in the goat and human.

PMID- 1029670
TI  - Oestradiol and progesterone: soluble receptor levels and metabolism in the uterus
      of the ovariectomized ewe.

PMID- 1029671
TI  - Effects of progesterone and oestradiol on endometrial metabolism and embryo
      survival in the ovariectomized ewe.

PMID- 1029672
TI  - The effects of age of egg and site of transfer on survival of transferred eggs in
      the ewe.

PMID- 1029673
TI  - The nature of ultrastructural changes induced by exposure of spermatozoa to
      lysolecithin.

PMID- 1029674
TI  - Information needs at the research/corporate management interface.

PMID- 1029675
TI  - The adequacy of physicians' and pharmacists' sources for drug information.

PMID- 1029676
TI  - Communicating about drugs.

PMID- 1029677
TI  - Consumers' methods of self-medication.

PMID- 1029679
TI  - Collection, storage, retrieval, and analysis of toxicological data using
      automated equipment and packaged software.

PMID- 1029678
TI  - Collection, evaluation, and dissemination of drug interaction information by the
      APhA Drug Interactions Evaluation Program.

PMID- 1029680
TI  - CTFA information services.

PMID- 1029681
TI  - FDA's cosmetic data information system: the program, design and public access to
      data.

PMID- 1029682
TI  - The nurse and drug surveillance.

PMID- 1029683
TI  - Impact of otc efficacy review on the industry.

PMID- 1029684
TI  - Effective industry/FDA liaison.

PMID- 1029685
TI  - Physician prescribing patterns. I. Technical aspects and initial analyses.

PMID- 1029686
TI  - The international register of lithium babies.

PMID- 1029688
TI  - Data processing coordination in NDA preparation.

PMID- 1029687
TI  - Use of a project management system on new drug development.

PMID- 1029689
TI  - Minicomputer system for product and ingredient information retrieval.

PMID- 1029690
TI  - Drug information communication via television.

PMID- 1029691
TI  - Meddoc three years later.

PMID- 1029692
TI  - [Study on the tissue trophism of spiramycin in tonsillar tissue].

PMID- 1029693
TI  - [Local treatment with bis-phenyl-(2-chlorophenyl)-1-imidazolil-methane of
      superficial mycoses of the pleural cavity overlying tuberculous or nontuberculous
      chronic suppuration].

PMID- 1029694
TI  - [Effects of phenobarbital on the distribution of erythromycin and erythromycin
      aspartate in the rat].

PMID- 1029695
TI  - [Absorption of kanamycin administered in aerosol form].

PMID- 1029696
TI  - [Aspects of antibacterial therapy using amikacin].

PMID- 1029697
TI  - [Tissue levels of fosfomycin and tobramycin in the rat kidney].

PMID- 1029698
TI  - [Influence of a constant magnetic field on mitotic activity and blast
      transforming effect of phytohemagglutinin].

PMID- 1029699
TI  - Physician maldistribution: can group practice come to the rescue?

PMID- 1029700
TI  - Bringing the mountain to Mohammed.

PMID- 1029701
TI  - Wall Streeters need doctors, too.

PMID- 1029703
TI  - Rural America. Green pastures for group practice.

PMID- 1029702
TI  - You're okay, we're all okay.

PMID- 1029704
TI  - Buying in - selling out.

PMID- 1029705
TI  - Medical audits: how Marshfield charts its course.

PMID- 1029706
TI  - HMO's--worth the risk?

PMID- 1029707
TI  - Labor relations: the future is now!

PMID- 1029708
TI  - Occupational Safety & Health Act--on multiemployer jobsite, when employees of any
      employer are affected by noncompliance with a safety standard, employer in
      control of work area violates act; employer not in control of work area does not
      violate act, even if his own employees are affected, provided the hazard is
      "nonserious".

PMID- 1029709
TI  - Autobiographical considerations on aphasic rehabilitation.

PMID- 1029710
TI  - [Language development disorders - delay of language development. Attempted
      definition].

PMID- 1029711
TI  - Sound-spectrographic cry analysis of normal and abnormal newborn infants. A
      review and a recommendation for standardization of the cry characteristics.

PMID- 1029712
TI  - [Pulse-telemetric behavior of stutterers, cured stuttere's and persons with no
      speech defects].

PMID- 1029713
TI  - A cephalometric study of structures of the head and neck during sustained
      phonation of covered and open qualities.

PMID- 1029714
TI  - [Detection of language disorders in children].

PMID- 1029715
TI  - [Significance of the kinesthetic reflex system for the control of phonation].

PMID- 1029716
TI  - [Diagnosis of superior-laryngeal-nerve paresis].

PMID- 1029717
TI  - Evaluation and outcome of traumatic aphasia in patients with severe verified
      focal lesions.

PMID- 1029718
TI  - Certification would hinder systems engineers.

PMID- 1029719
TI  - Two eastern schools train health care engineers.

PMID- 1029720
TI  - Productivity management: integral element in the management process.

PMID- 1029721
TI  - Multihospital and inhouse MEs arrive at conclusions.

PMID- 1029723
TI  - Naevus lipomatosus cutaneous superficialis of Hoffmann-Zurhelle.

PMID- 1029722
TI  - Coxsackie virus infection simulating smallpox.

PMID- 1029724
TI  - Buschke-Loewenstein tumour.

PMID- 1029725
TI  - The effects of dark isolation on the performance of a white-black discrimination
      task in the rat.
AB  - Four experiments were performed on rats using a white-black discrimination task.
      In Exp. 1 the animals that were isolated in darkness for four hours after each
      learning trial performed with fewer errors than the animals that spent the same
      posttrial periods in enriched environments in groups. In Exp. 2 training was
      carried further and retention after 10 days was investigated. The isolated
      animals again performed with fewer errors. In Exp. 3 a control was added to the
      Isolated and Enriched conditions. Animals in the control group were returned to
      their home cages after each training trial. No difference was found between
      Enriched and Control animals. In Exp 4 Dark-Isolated, Light-Isolated, Dark
      Crowded and Light-Crowded groups were used. The performance of the two Dark
      treated groups was superior to that of the Light-treated groups. The findings are
      discussed with reference to interference and consolidation theory.

PMID- 1029726
TI  - Alteration of escape from rewarding electrical brain stimulation by D
      amphetamine.
AB  - Rats were trained both to barpress for and escape from locus coeruleus, midbrain
      periaqueductal gray and hypothalamic stimulation. Rate-intensity functions for
      intracranial self-stimulation (ICSS) behavior and latency-intensity functions for
      escape behavior were obtained for each electrode site in each animal. Following
      baseline, d-amphetamine was administered and responding was compared with the
      saline condition for both rate-intensity and latency-intensity functions. ICSS
      response rates were enhanced by d-amphetamine at all loci, particularly at
      threshold intensities, while escape responding was biphasically affected by d
      amphetamine at all loci. D-amphetamine increased escape latencies at intensities
      which, under saline, elicited short escape latencies, while decreasing escape
      latencies at intensities which, under saline, elicited long escape latencies. A
      significant correspondence was noted between intensities which, under the
      influence of d-amphetamine, both elicited longer escape latencies and higher ICSS
      response rates, suggesting that in both ICSS and escape paradigms, animals were
      titrating the duration of the stimulus train. No site-specific effects of d
      amphetamine upon escape behavior were noted.

PMID- 1029727
TI  - On time space and the cerebral hemispheres: a theoretical note.
AB  - The two well know dichotomies in hemispheric functions--temporal-spatial, and
      analysis-synthesis (extraction-integration)--are combined in a unified theory of
      cerebral dominance. The two dichotomies are first considered within the framework
      of a two-stage model of information processing, and subsequently reduced to the
      extraction and integration operations performed at each of the two stages. At the
      first stage, the respective operations of extraction and integration applied on
      the sensory stream yield the spatiotemporal organization of events. At the second
      stage, these operations are expressed in progressively more complex organizations
      such as verbal coding and pictorial imagery. The model is finally generalized
      into a multiple-stage model. Some empirical consequences are derived.

PMID- 1029728
TI  - Lateralization of language and spatial functions in left-handed populations.
AB  - The level of performance in the execution of a tactual-linguistic task was
      studied in two left-handed populations, one with language lateralized to the left
      and the other with language lateralized to the right hemisphere, according to
      Kimura's dichotic digit test. The results showed that left-handers with speech
      most likely lateralized to the left hemisphere performed significantly better in
      the tactual-linguistic task with the left hand, while the ones with speech
      probably lateralized to the right hemisphere, did better with the right hand. The
      data suggest that integration of functions asymmetrically represented is
      facilitated by their differential lateralization.

PMID- 1029729
TI  - Biochemical studies of taste sensation. V. Binding of quinine to bovine taste
      papillae and taste bud cells.

PMID- 1029731
TI  - Sometimes a "non-returnable" basis for drugs is justified.

PMID- 1029730
TI  - Neuronal circuits involved in learning: the use of modifiable synapses in the
      simulation of behavior.
AB  - Our present knowledge of brain structure and function requires that any model of
      neuronal circuitry designed to account for learning must satisfy three
      conditions. It must (1) meet economy restrictions on the number of cells in the
      brain, (2) use the same set of cells to account for a number of different
      behaviors, and (3) not require a detailed embryological specification of its
      connections. Previously published models have failed to meet one or more of these
      conditions. In this paper, a model is presented which does satisfy them, and in
      doing so accounts in detail for classical conditioning, operant conditioning, and
      other learning tasks. The model employs the types of synapses proposed by Burke
      and Hebb in simple modular circuits as a means of providing independent storage
      of information at each modifiable synapse.

PMID- 1029732
TI  - A pharmacist's experience in a teaching program for patients on anticoagulant
      medication.

PMID- 1029733
TI  - The pharmacy director of the future: a specialized generalist?

PMID- 1029734
TI  - Pharmaceutical services for the primary care health team.

PMID- 1029735
TI  - Planning for pharmacy service in a small hospital.

PMID- 1029736
TI  - "What is your address and phone number, Dr. Wallace?".

PMID- 1029737
TI  - A question: should pharmacists make permanent entries on patients' charts?

PMID- 1029738
TI  - A question: should pharmacists make permanent entries on patients' charts?
      Answers.

PMID- 1029739
TI  - Establishing modern pharmacy service in a large mental hospital.

PMID- 1029740
TI  - Evaluation by physicians of a pharmacy newsletter.

PMID- 1029741
TI  - Adverse drug reactions: further controversy.

PMID- 1029742
TI  - On the pharmaceutical orphan.

PMID- 1029743
TI  - On the pharmaceutical orphan.

PMID- 1029744
TI  - On the pharmaceutical orphan.

PMID- 1029746
TI  - On the subjectivity of personality theory.
AB  - Every theorist of personality views the human condition from the unique
      perspective of his own individuality. As a consequence, personality theories are
      strongly influenced by personal and subjective factors. These influences are
      partially responsible for the present day lack of consensus in psychology as to
      basic conceptual frameworks for the study of man. The science of human
      personality can achieve a greater degree of consensus and generality only if it
      begins to turn back on itself and question its own psychological foundations. The
      role of subjective and personal factors in this field can be studied and made
      more explicit by means of a psychobiographical method which interprets the major
      ideas of personality theories in the light of the formative experiences in the
      respective theorists' lives. This method is briefly illustrated by an examination
      of the influence of personal experiences on theoretical concepts in the work of
      Carl Jung, Carl Rogers, Wilhelm Reich, and Gordon Allport. The subjective factors
      disclosed by psychobiographical analysis can bee seen to interact with influences
      stemming from the intellectual and historical context within which the theorist
      work. The psychobiographical study of personality theory is only one part of a
      larger discipline, the psychology of knowledge, which would study the role of
      subjective and personal factors in the structure of man's knowledge in general.

PMID- 1029747
TI  - The need for accuracy in historiography.
AB  - Historiographers must be especially accurate in their citations and references.
      An article by Wettersten contained numerous incorrect references and citations,
      and factual errors. Corrections are provided.

PMID- 1029748
TI  - Response to Littman: the need for recognition of theory in historiography.

PMID- 1029749
TI  - Haemoglobin changes, diet and anthropometric measurements in adolescent male
      detainees.
AB  - A fall in haemoglobin noted in detainees in a Detention Centre in 1972 prompted a
      more detailed study to find possible reasons for this change. A significant fall
      in haemoglobin occurred between the first and third day after arrival, and no
      further fall had taken place eight weeks later. There was no evidence to suggest
      dehydration on arrival, or of any dietary deficiency during their stay. The fall
      in haemoglobin concentration occurred in non-smokers and smokers alike. It is
      suggested that the initial haemoglobin was higher than normal, possibly due to a
      physiological response to stress, and that it returned to normal by the third day
      when the boys had become accustomed to their new environment.

PMID- 1029750
TI  - Factors contributing to osteomalacia in the elderly and in the Asian communities
      in the United Kingdom.

PMID- 1029751
TI  - The role of carbohydrates, and of sugar in particular, in our diet.

PMID- 1029752
TI  - Dietitians in the EEC: 1. The Netherlands. A dietitian in a dental health
      programme.

PMID- 1029753
TI  - Computerised dietary calculations: an interactive approach.

PMID- 1029754
TI  - Computerised nutritional analysis in the dietetic department of a teaching
      hospital.

PMID- 1029755
TI  - MAOIs and food-fact and fiction.

PMID- 1029756
TI  - Long-term intensive psychiatric hospital treatment. Coverage for psychiatric
      treatment.

PMID- 1029757
TI  - Long-term intensive psychiatric hospital treatment. Claims review.

PMID- 1029758
TI  - Recombinant influenza-virus vaccines. III. Isolation and preliminary
      characterization of so-called antigenic recombinant influenza viruses.

PMID- 1029759
TI  - Recombinant influenza-virus vaccines. IV. Segregation of antigenic and some
      biological properties of Influenza virus neuraminidase by recombination.

PMID- 1029760
TI  - [Structural disorders of the lung and their significance].

PMID- 1029761
TI  - [Anesthetic methods and respiration in patients with preoperative impairment of
      pulmonary function].

PMID- 1029762
TI  - [Physiopathology of chronic bronchopulmonary diseases].

PMID- 1029763
TI  - [Necessary and possible monitoring of respiration during anesthesia].

PMID- 1029764
TI  - [Respiratory problems in the anesthesia of infants].

PMID- 1029765
TI  - [Respiratory emergencies as anesthesia hazards].

PMID- 1029766
TI  - [Possibilities and limitations of oxygen therapy].

PMID- 1029767
TI  - [Summary of the discussion on the subject: "The special risk in anesthesia"].

PMID- 1029768
TI  - [Significance of opsonification in antimicrobial defense and its therapeutic
      consequences].

PMID- 1029769
TI  - [Respiratory training, breathing exercises, aerosol therapy and inhalation
      respiration].

PMID- 1029770
TI  - [Respiratory function tests for the identification of risk patients in
      anesthesiology].

PMID- 1029771
TI  - [Pharmacological effects and mutual relationships of premedication and
      anesthetics on respiration].

PMID- 1029772
TI  - Cold-sensitive variants of Staphylococcus aureus and their stimulation by
      penicillins and cephalosporins.
AB  - Cold-sensitive (Cs) variants were obtained from ageing broth cultures of the
      Oxford strain of Staphylococcus aureus (NCTC 6571) and other penicillin-sensitive
      strains of this species. Growth of all strains was severely retarded on certain
      media at 30 degrees C but was stimulated by the addition of penicillins and
      cephalosporins. Revertants were derived which behaved as the parent cells did
      with respect to growth temperature requirements and response to these
      antibiotics.

PMID- 1029773
TI  - A qualitative and quantitative study of the fatty acid composition of selected
      micro-organisms.
AB  - Fatty acid content was found to be an important parameter in the identification
      and numerical taxonomy of many micro-organisms. Isolates of the same species and
      genus as well as members of many well defined groups, such as the
      Enterobacteriaceae, were included in the study. A direct methylation procedure of
      the bacteria was found to be accurate, efficient and rapid. Fatty acids were
      found to be reliable indicators of micro-organisms in group, generic, specific
      and strain identification. Other biochemical tests were especially valuable when
      used in conjunction with fatty acid profiles in identification and classification
      of the bacteria studied.

PMID- 1029774
TI  - [Advanced training of nurse technicians for use in national defense work and in
      mass disasters].

PMID- 1029775
TI  - [Medical aid to persons injured in mass disasters].

PMID- 1029776
TI  - [Radiological, chemical and biological decontamination of injured and sick].

PMID- 1029777
TI  - [Treatment of burns in war].

PMID- 1029779
TI  - [Free exchange of work in self-managing communities with interest in the health
      field].

PMID- 1029778
TI  - [Standards in the organization of work at nursery schools].

PMID- 1029780
TI  - [Socio-medical aspects of premature labor].

PMID- 1029781
TI  - [Prevention of birth injuries].

PMID- 1029782
TI  - [Special problems in the intensive care and treatment of newborn infants --
      maintaining of body temperature--].

PMID- 1029783
TI  - [Intensive care of the infant from high risk pregnancy].

PMID- 1029784
TI  - [Diagnosis, intensive care and treatment of cardiovascular insufficiency].

PMID- 1029785
TI  - [Respiratory and cardiac arrest with special reference to the newborn infant and
      infant].

PMID- 1029786
TI  - [Therapy and care of a comatous child].

PMID- 1029787
TI  - [Organization, transport, admission and permanent control of the severely sick
      child].

PMID- 1029788
TI  - [The epidemiological picture of tuberculosis in the Socialist Federal Republic of
      Yugoslavia and prognosis of its propagation].

PMID- 1029789
TI  - [Influence of antitubercular agents on the length of treatment of pulmonary
      tuberculosis].

PMID- 1029790
TI  - [Patients with chronic tuberculosis as a problem in tuberculosis control.
      Information from the central registries of Slovenia and the SAP Vojvodina].

PMID- 1029791
TI  - [Dispensary health care of patients with lung diseases. Perspectives of the
      competence of the dispensary for lung diseases and tuberculosis].

PMID- 1029792
TI  - [Position of pneumophthisiology in medicine and health care and its
      perspectives].

PMID- 1029793
TI  - [Possibilities of direct BCG vaccination in children and justification for the
      change of regulations on immunization].

PMID- 1029794
TI  - [Results of analysis of newly registered cases of respiratory-tract tuberculosis
      in children on the territory of Serbia excluding SAP].

PMID- 1029795
TI  - [Anatomy, embryology, physiology and pathophysiology of the mediastinum].

PMID- 1029796
TI  - [Methods for the examinations of the mediastinum].

PMID- 1029797
TI  - [Classification of the mediastinal tumors].

PMID- 1029798
TI  - [Benign tumors of the mediastinum].

PMID- 1029799
TI  - [Pseudotumorous formations in the mediastinum].

PMID- 1029800
TI  - [Pathological anatomy of thymus neoplasms].

PMID- 1029801
TI  - [Treatment and classification of mediastinal processes].

PMID- 1029802
TI  - [Mediastinal injuries].

PMID- 1029803
TI  - [Diaphragmatic hernia and rupture].

PMID- 1029804
TI  - [Significance of mediastinal and diaphragmatic manifestations in the evaluation
      of the operability of bronchial carcinoma].

PMID- 1029805
TI  - Monoiodotyrosine: effects on tissue amines and cold survival.
AB  - The effects of monoiodotyrosine (MIT) on cold survival and levels of tissue
      amines in rats were studied. MIT was found to impair cold suvival and to lower
      levels of norepinephrine (NE). These experiments confirm previous pharmacologic
      evidence that MIT has an anti-adrenergic effect. Cold stress lowered brain NE
      levels but failed to lower brain dopamine levels, a finding consistent with
      current views of the role of brain mechanisms in temperature regulation.

PMID- 1029806
TI  - Habituation of visually evoked responses in man: a study of its time course.
AB  - Twelve subjects were tested in a study of short-and long-term habituation of
      visually evoked responses to flashes with fixed and random interstimulus
      intervals. Long-term habituation was evalutated using blocks of 64 responses, and
      'sliding' averages were calculated for estimation of the short-term habituation.
      Two measures of averaged evoked responses amplitude were used: N1-P2 amplitude
      and mean level of responses between 70 and 220 msec. A gradual decrease of
      amplitude of the vertex responses was observed during the first 3 min of
      stimulation, the greater part of this decrement occurring during the first 15
      sec, with fixed interstimulus intervals. No decrement was observed with random
      interstimulus intervals. As the time course of long-term habituation may be
      influenced by fluctuations in the levels of arousal and attention, a decrement of
      the responses in a short period of stimulation is more likely to represent true
      habituation. The procedure of 'sliding' average presents some advantages over the
      averaging by ordinal positions used in some studies and is more satisfactory in
      investigations of such noncooperative subjects as psychiatric patients.

PMID- 1029807
TI  - Bioavailabiltity and side effects of different lithium carbonate products.
AB  - Among the three lithium preparations tested, no significant difference was found
      in the bioavailability, as expressed in serum and erythrocyte lithium
      concentrations and urinary lithium output. The side effect reports, however,
      varied significantly among the types of lithium under study. The slower the
      absorption of a particular preparation, the fewer the side effects. The results
      of this study support the view that preference should be given to lithium
      preparations with slow-release properites, particularly in side-effect-prone
      subjects.

PMID- 1029808
TI  - Glucose-insulin metabolism in herion addicts.
AB  - The insulinemic and glycemic response to a glucose load (100 g per os) was
      studied in 21 heroin addicts, 16 males and 5 females, age 16-28 years, history of
      addiction lasting from 6 months to 4 years with heroin alone (from 0.5 to 1.5
      g/day i.v.). Nine normal sujects, from the hospital staff, 4 females and 5 males
      matched for age were use as control. The insulinemic and glycemic response to a
      glucose load was examined immediately after hospitalization, while the patients
      were still on heroin, 48 h later off drugs, and in 10 of the 21 cases 5 days
      later still off drugs. From the results obtained, it appears that in heroin
      addicts the glycemic response to the glucose load shows a delayed peak time. The
      insulin curves show increased insulin peaks, delayed peak time and prolonged
      hyperinsulinemia. The pathomechanism of heroin in inducing the above-metioned
      impairments is discussed, taking also in cosideration the possible influence of
      the drug on the neurotransmitter regulation of insulin.

PMID- 1029809
TI  - Application of factor analytic procedures to complex evoked potential
      measurements in psychiatric research.
AB  - Several factor analytic procedures were applied to data gathered with a modified
      somatosensory evoked potential (SEP) recovery function prodecure in 56 non
      patients and 224 psychiatric inpatients. The data were analyzed for each option
      reflected in three main issues. (1) Which group should be used for calculating
      the basic factor structure--normals only or all subjects? (2) Should measurements
      be preadjusted for covariance with variables known to obscure events of interest?
      (3) Should varimax rotation be used, or are principal components sufficient?
      Using two criteria, interpretability of factors in relation to experimental
      design, and their ability to discriminate clinical groups, it appeared that: (1)
      choice of either population yielded similar results; (2) when measurements were
      pre-adjusted for covariance more interpretable factors, which also yielded
      clinical discriminations, were obtained by varimax rotations than by principal
      components, and (3) when data were not adjusted by covariance, principal
      component analysis produced a factor which, although less interpretable in
      relation to experimental design than the varimax factors, provided equivalent
      clinical discriminations.

PMID- 1029810
TI  - Short term effects of feeding male subjects with glucose syrup fractions and D
      glucose.

PMID- 1029811
TI  - Effect of dietary iron level on efficiency of converting food iron into
      hemoglobin by the anemic rat.
AB  - The effects of varying the dietary levels of ferrous sulfate or ferric
      orthophosphate on the efficiency of the conversion of dietary iron into
      hemoglobin iron, was evaluated with the anemic rat. Weanling male rats were made
      anemic by feeding a semipurified diet containing 8.4 mg iron/kg, and by bleeding.
      They were divided into nine groups so that hemoglobin levels and body weights
      were similar. The rats were fed the basal diet or basal diet plus 12, 24, 36 and
      48 mg iron/kg diet provided as ferrous sulfate or ferric orthophosphate. The rats
      were fed 10 g daily of the respective diets for 10 consecutive days. The
      efficiency of the conversion of dietary iron into hemoglobin iron was not
      significantly affected by dietary level of either iron salt. It was determined
      that ferric orthophosphate was 51% as efficient as ferrous sulfate for hemoglobin
      regeneration in the anemic rat.

PMID- 1029812
TI  - Regulation of blood pyridoxal phosphate in riboflavin deficiency in man.
AB  - Synthesis and breakdown of pyridoxal phosphate by erythrocytes were studied in
      subjects with oral lesions before and after treatment with riboflavin. In vivo
      conversion of pyridoxine to pyridoxal phosphate as well as in vitro synthesis of
      pyridoxal phosphate by erythrocytes were lower in subjects with lesions of the
      mouth and improved markedly after treatment with riboflavin. Erythrocyte
      phosphatase activity, with pyridoxal phosphate as substrate, was lower in
      riboflavin-deficient subjects and showed an increase after treatment with
      riboflavin.

PMID- 1029813
TI  - The importance of motivation in the adherence to dietary advice. A one-year
      follow-up study of middle-aged women with a supposed risk to develop diabetes.

PMID- 1029814
TI  - Effects of a fat-reduced diet on the faecal excretion of radioactivity following
      administration of 14C-cholic acid and on the duodenal concentration of bile salts
      in patients with ileal disease.
AB  - The fraction of faecal radioactivity excreted after intravenous administration of
      14C-labelled cholic acid decreased in most patients with ileopathy and bile salt
      malabsorption when the dietary daily fat content was reduced from 100 to 40 g.
      The decreased faecal cholic acid loss might be due to increased bile salt
      absorption and decreased emptying of the gall-bladder on the fat-reduced diet. A
      simplified method to determine the corrected 24-hour excretion of radiologically
      labelled bile salts is described.

PMID- 1029815
TI  - The effect of ventromedial hypothalamic lesions on metabolism and insulin
      secretion in rats on a controlled feeding regimen.
AB  - The metabolic effect of ventromedial hypothalamic (VMH) lesions, which are known
      to cause hyperphagia and obesity, has been studied in rats kept on a controlled
      light and food regimen. The animals were sacrificed at 4 different times during
      the second postoperative day. A feeding-induced hypersecretion of insulin was
      found to the VMH-lesioned animals. It was accompanied by a marked hypoglycemia as
      compared to the control groups during the feeding period. The glycogen content of
      liver and diaphragm in the lesioned groups is increased as compared to the
      controls during the same period. The VMH-lesioned animals showed
      hypertriglyceridemia both in the fed and fasted state, whereas the postabsorptive
      plasma levels of free fatty acids and glycerol were decreased. An increased level
      of urea was observed in all lesioned groups. This is in accordance with the
      demonstrated protein catabolism which follows VMH lesions.

PMID- 1029816
TI  - Thymic weight in pantothenic acid deficiency.
AB  - The purpose of this note is to emphasize the significant effects of nutritional
      factors, in this case pantothenic acid, on growth and development of rat thymus.
      Low antibody titers against various infectious agents in pantothenic acid
      deficiency and skin graft tolerance in pyridoxine deficiency warrant an
      assessment of the effects of vitamins on the growth and development of the thymus
      and consequently on the immune response.

PMID- 1029817
TI  - Erythropoietic response of anemic rats to enriched white bread and bread ash.
AB  - Iron-deficient rats were rehabilitated with diets supplying iron from white wheat
      bread, bread ash or ferrous sulfate as a standard. The relative biological value
      of iron in bread or its ash was greater when evaluated from red blood cell count
      than when estimated from hemoglobin concentration. Ash obtained by heating bread
      in a muffle furnace and reduced with hydrogen was more effective in stimulating
      blood cell production than could be accounted for by its iron content alone.

PMID- 1029818
TI  - Influence of litter size on lipid composition in infant mice.
AB  - The amount of milk available to each member of the litter was varied by adjusting
      the number of mice pups to 4, 8 or 12 per dam. The total fatty acid content of
      the carcass of the young increased for 2 weeks, and there was more in the well
      fed groups. The fatty acid contents decreased thereafter transiently in all
      groups until weaning. The milk diet contributed major quantities of lauric and
      myristic acids to peripheral tissues but not to the liver. Undernourishment
      during neonatal life was associated with a relative reduction in palmitoleic,
      oleic and linoleic acids in lipids of the carcass. In contrast the carcass of the
      progeny subjected to overall dietary abundance showed relative increase in
      palmitoleic, oleic and linoleic acids at the expense of stearic acid.

PMID- 1029819
TI  - The influence of interrrupted vitamin D metabolism on acute low calcium
      adaptation in the rat.
AB  - The small intestine of animals place on a low calcium diet adapts to the dietary
      restriction by transporting calcium more efficiently. Adaptation has been
      observed in most mammalian species; however, the mechanism of adaptation has not
      been well defined. Recent evidence indicates that 1,25-dihydroxycholecalciferol
      [1,25(OH)2-D3], the active metabolite of vitamin D, may be involved in the
      process of adaptation. The present study was designed to examine the inflluence
      of experimental interruption of vitamin D metabolism on acute low calcium
      adaptation. Partial hepatectomy, cortisone treatment and dietary strontium
      supplements were used to inhibit the production of 1,25(OH)2-D3. In separate
      experiments partial hepatectomy produced a 38% reduction in adaptation; cortisone
      treatment (5 mg/day, s.c.) caused a 88% reduction and dietary strontium abolished
      adaptation completely. The possible roles of parathyroid hormone and 1,25(OH)2-D3
      and their relationships in the process of adaptation are discussed.

PMID- 1029820
TI  - Effect of protracted intermittent fasting on the activities of enzymes involved
      in energy metabolism, and on the concentrations of glycogen, protein and DNA in
      skeletal muscle of obese women.
AB  - In the quadriceps femoris muscle of obese women the glycogen concentration was
      significantly lower than in the control group, while protein and DNA values
      showed no significant differences. After 37 days of intermittent fasting, which
      consisted of repeated 5-day fasts alternating with 3-day intervals on 500
      KCal/day with 60 g protein, in a group of 21 obese women a significant decline of
      the hexokinase activity in skeletal muscle was found. Other enzymes:
      triosophosphate dehydrogenase, lactate dehydrogenase, glycerol-3-phosphate
      dehydrogenase, citrate synthase, malate dehydrogenase and hydroxyacyl-CoA
      dehydrogenase showed no significant changes. There was a significant fall in
      concentration of DNA and and glycogen, but the protein concentration did not
      change.

PMID- 1029821
TI  - Body lipids of guinea pigs exposed to different dietary fats from mid-gestation
      to 3 months of age.
AB  - Pregnant guinea pigs were fed one of three diets: a control low-fat diet, or a
      high-fat diet containing maize oil or beef dripping. At birth some animals were
      killed and the remainder reared on the same diet as their mothers till 3 months
      old. Body weight, weight of various adipose tissue depots, size and number of fat
      cells were measured. Animals fed high-fat diets were fatter than control animals.
      On all diets females were fatter than males. In both instances the increase in
      adipose tissue mass was attributable to enlargement of fat cells. The composition
      of dietary fat had little influence on the cellularity of adipose tissue.

PMID- 1029822
TI  - Body lipids of guinea pigs exposed to different dietary fats from mid-gestation
      to 3 months of age. II. The fatty acid composition of the lipids of liver,
      plasma, adipose tissue, muscle and red cell membranes at birth.
AB  - Pregnant guinea pigs were fed one of three diets: a commercial low-fat diet, or a
      high-fat diet containing maize oil or beef dripping. The young were killed at
      birth and the fatty acid composition of the lipids of the liver, plasma, adipose
      tissue, quadriceps muscle and red cell membranes was determined. Compared with
      those fed the commercial diet the tissue of the young of mothers fed maize oil
      had an increased percentage of linoleic acid whereas in those of the young of
      mothers fed beef dripping, the percentage of oleic acid was significantly higher.
      These changes occurred both in the triglycerides and in the membrane
      phospholipids (with the exceptin of sphingomyelins) of all tissues examined.
      These results demonstrate that the fatty acid composition of the tissue lipids of
      the newborn guinea pig can be influenced by the fatty acid composition of the
      maternal diet. Changes in the fatty acid composition of membrane phospholipids
      can be as great as those in storage lipids. This raises the question of long-term
      physiological significance for the animal.

PMID- 1029823
TI  - Body lipids of guinea pigs exposed to different dietary fats from mid-gestation
      to 3 months of age. III. The fatty acid composition of the lipids of plasma,
      adipose tissue, liver and muscle at 3 months of age.
AB  - Pregnant guinea pigs were fed one of three diets: a 'control' low-fat diet, or a
      high-fat diet containing maize oil or beef dripping. Offspring were reared on the
      same diet as their mothers and when they were 3 months old, fatty acid
      compositions of the lipids of the adipose tissue, blood plasma, liver and muscle
      were analysed. The proportion of linoleic acid was elevated in both the storage
      triglycerides and the tissue phosphoglycerides of animals fed 'maize' diet
      whereas in the 'beef' group the proportion of oleic acid was significantly
      elevated compared with controls. A substantial part of these diet-induced changes
      in tissue fatty acid composition had occurred by the time animal was born; only
      minor changes took place in the subsequent 3 months of feeding.

PMID- 1029824
TI  - [Statistical characteristics of motor reaction sequence is random choice].

PMID- 1029825
TI  - [Use of a mathematical model for identifying the learning parameters].

PMID- 1029826
TI  - [Program system for the mathematical support of psychophysiological research on
      the CNS].

PMID- 1029827
TI  - [Use of the "Adaptron" device for evaluating the mental deviations in
      cerebrovascular arteriosclerosis].

PMID- 1029828
TI  - [Use of the "Adaptron" device for determining the patient's condition following
      anesthesia].

PMID- 1029829
TI  - [Use of the "Adaptron" device for predicting the successfulness of vocational
      training].

PMID- 1029830
TI  - [Use of the "Adaptron" device for studying the neurodynamics of the associative
      process].

PMID- 1029831
TI  - [Test program for the quantitative evaluation of the temporal characteristics of
      attention].

PMID- 1029832
TI  - [Reliability of determining the indices of attention activity].

PMID- 1029833
TI  - [Problems of creating devices for quantitative functional tests of the CNS].

PMID- 1029834
TI  - [Reliability of the individual CNS characteristics in human reaction sequential
      learning].

PMID- 1029836
TI  - [Apparatus for realizing algorithms in psychophysiological research data
      processing].

PMID- 1029835
TI  - [Automated experiment for measuring the rate of human assimilation of
      sensorimotor programs].

PMID- 1029837
TI  - [Index of the heart rhythm as an individual measure of emotional stress].

PMID- 1029838
TI  - [Approval testing of technics for standardizing the initial memory state].

PMID- 1029839
TI  - [Algorithms for choosing the measurable parameters to obtain reliable indices of
      the state of the CNS].

PMID- 1029840
TI  - [Interpretation of the parameters obtainable with the aid of the "Adaptron"
      device].

PMID- 1029841
TI  - [Choice of adequate data processing methods for a set of psychophysiological
      procedures].

PMID- 1029842
TI  - [Use of a reaction sequential learning model for assessing the significance of
      experimental indices].

PMID- 1029843
TI  - [Use of mathematical models for choosing the informative parameters and
      interpreting the measurable indices].

PMID- 1029844
TI  - [Analysis of the mechanism of stimulus discrimination using mathematical models].

PMID- 1029845
TI  - Variations in mineralization of teeth in tissue culture.

PMID- 1029846
TI  - [Variability of parameters in enzyme kinetics. 1. Intermethod oscillations].
AB  - Kinetic parameters of urease activity have been determined by five different
      methods, namely: Henry, Lineweaver-Burk, Hofstee, Woolf and Cornish-Eisenthal. In
      no instance different methods yielded the same values for the set of parameters
      (Km and Vmax).

PMID- 1029847
TI  - [Anti-amylase activity in preparations of phytohemagglutinins].

PMID- 1029848
TI  - [Determination of normal values of plasma glucose in students entering the Sao
      Paulo University].

PMID- 1029849
TI  - [3 cases of human intestinal mite infestation in the South of Veracruz].

PMID- 1029850
TI  - [Serologic study with parasitic antigens in children with eosinophilia].

PMID- 1029851
TI  - [Study of an explosive outbrake of gastroenteritis by Salmonella enteritidis,
      Infantis serotype].

PMID- 1029852
TI  - [Accidental primary cutaneous inoculation of coccidioidomycosis starting with a
      clinical case].

PMID- 1029853
TI  - [Study of intestinal parasitic diseases comparing 2 infantile populations of
      different socioeconomical levels].

PMID- 1029854
TI  - [Incidence of intestinal helminthiasis in Mexico].

PMID- 1029855
TI  - [Management of the patient with recurrent ulcer].

PMID- 1029856
TI  - Zollinger-Ellison syndrome.

PMID- 1029857
TI  - [What would I do if I had a peptic ulcer?].

PMID- 1029858
TI  - Acute ulceration of stomach and duodenum.

PMID- 1029859
TI  - [The structure and function of gastric and duodenal mucosa].

PMID- 1029860
TI  - [Pathological anatomy of peptic disease].

PMID- 1029861
TI  - [Production of hydrochloric acid, mucus and enzymes].

PMID- 1029862
TI  - [Stimulation and inhibition of gastric secretion].

PMID- 1029863
TI  - [Gastric secretion taste and their clinical significance].

PMID- 1029864
TI  - Gastrins.

PMID- 1029865
TI  - [Extragastric factors of hypersecretion].

PMID- 1029866
TI  - Pathophysiology of peptic ulcer.

PMID- 1029867
TI  - [Peptic ulcer. Clinical picture].

PMID- 1029868
TI  - [Radiologic diagnosis of peptic ulcer].

PMID- 1029869
TI  - [Endoscopic diagnosis of peptic disease].

PMID- 1029870
TI  - [Personality of the ulcer patient].

PMID- 1029871
TI  - New concepts on the medical treatment of peptic ulcer.

PMID- 1029872
TI  - [Indications for surgery in the treatment of duodenal ulcer].

PMID- 1029874
TI  - [Surgical procedures in duodenal ulcer].

PMID- 1029873
TI  - [Surgical treatment of gastric ulcer].

PMID- 1029875
TI  - [Selective vagotomies].

PMID- 1029876
TI  - [Post-vagotomy sequelae and their medical treatment].

PMID- 1029877
TI  - Posgastrectomy syndromes and their treatment.

PMID- 1029878
TI  - Hemodialysis with single femoral vein catheter - reduced recirculation with short
      catheter.

PMID- 1029879
TI  - The estimation of blood flow to hemodialyzers by bubble time.
AB  - Reliable estimation of blood flow to hemodialyzers is essential to the accurate
      prescription of therapy. Customarily an air bubble is timed as it traverses a
      racetrack of known volume and blood flow is calculated from the formula Qb
      (ml/min) = (volume/BT) (60 sec/min). The linearity of this relationship has
      recently been questioned. Air bubble velocities were statistically fit to
      measured blood flows over 6 hematocrit values. From the resulting relationship,
      Qb (ml/min) = 62 (vol/L) (L/BT)0.96, one can generate a table relating velocity
      to flow for clinical use.

PMID- 1029880
TI  - Performance and clinical use of a convertible hemodialysis (HD) - ultrafiltration
      (UF) system.
AB  - A hemodialysis-ultrafiltration system has been developed and evaluated. It may be
      used either as a conventional hemodialyzer or as a nondialytic ultrafilter. When
      used as a dialyzer an ultrafiltration controller is required to fix
      ultrafiltration rate at the desired level. Rates of low molecular solute removal
      are compatible with those observed in commercially available artificial kidney
      systems, higher clearances are obtained for middle molecules, and the rate of
      ultrafiltration can be controlled within narrowly prescribed limits.

PMID- 1029881
TI  - Sequential ultrafiltration and diffusion as alternative to conventional
      hemodialysis.

PMID- 1029882
TI  - Some acid-base and metabolic aspects of high mass-transfer hemodialysis.

PMID- 1029883
TI  - Nutritional intake, somatomedin activity and linear growth in children undergoing
      hemodialysis.
AB  - Reduced somatomedin activity was uniformly present pre-dialysis in 7 children
      with end-stage renal disease. Somatomedin activity improved in 6 of the 7
      patients following a single 5 hr hemodialysis. Percent normal growth correlated
      with post-dialysis somatomedin activity in 6 of the 7 children. No correlation
      was present between percent normal growth and calorie or protein intake. Reduced
      somatomedin activity in children with end-stage renal disease appears to be due
      to a circulating uremic inhibitor(s). Somatomedin activity may be a useful in
      vitro test for adequacy of dialysis in children. Further efforts are necessary to
      identify the inhibitor(s) of somatomedin activity in uremia.

PMID- 1029885
TI  - Effects of decreasing dialysate magnesium in patients with chronic renal failure.

PMID- 1029884
TI  - Dihydrotachysterol (DHT) and supplemental calcium therapy in dialysis patients.

PMID- 1029886
TI  - LeVeen shunt (LS): long-term therapy for idiopathic ascites of chronic renal
      failure.

PMID- 1029887
TI  - Studies on the mechanism of the anemia of renal insufficiency.
AB  - 1. The present studies have demonstrated that the titers of erythropoietin may be
      elevated to varying degrees in patients with anemia associated with end-stage
      renal disease. However, the increase in erythropoietin titers was apparently not
      sufficient to meet the increase in demand for new red blood cells created by
      their shortened life span and the inhibitors of heme synthesis and/or erythroid
      colony forming cells (CFU-E). 2. Inhibitors of heme synthesis were demonstrated
      in the plasma of some but not all patients with anemia associated with renal
      disease and in rabbits 72 hrs following bilateral nephrectomy. 3. CFU-E were both
      increased and decreased in the bone marrows of the chronic anemic uremic rabbits,
      when compared with that of sham operated controls, 14 and 21 days after 5/6th
      nephrectomy and depended on the rate of regeneration of the renal erythropoietic
      and excretory functions. CFU-E in marrows of 5/6th nephrectomy rabbits were
      decreased after 35 days. 4. An inhibitor of CFU-E was increased in the sera from
      chronic anemic uremic rabbits, when compared with that of the sham-operated
      controls, 35 days after 5/6th nephrectomy. 5. It is possible that in the anemia
      of uremia in addition to inadequate production of erythropoietin there is a
      defect in the differentiation of the CFU-E into the heme synthesizing erythroid
      series due to the presence of a specific inhibitor of CFU-E and/or heme
      synthesis.

PMID- 1029888
TI  - Anemia in dialysis patients - inevitable or correctable?

PMID- 1029889
TI  - Echocardiographic findings in stable hemodialysis patients.

PMID- 1029891
TI  - Improved survival in older, sicker patients begun on maintenance hemodialysis.

PMID- 1029890
TI  - Nonpercutaneous transmission of hepatitis B to the families of hemodialysis
      patients.
AB  - 1. Fifteen percent of the hemodialysis patients were carriers of HBsAg. 2. Thirty
      one percent of the carriers' contacts had HBAb in their blood. 3. Spouse of
      carriers had a higher prevalence of positive HBAb than any other family contact.
      4. Only 6 out of 17 patients transmitted the virus to their contacts. 5. None of
      the contacts of the staff, with history of hepatitis B, had evidence of
      hepatitis. 6. Contacts with positive HBAb had no evidence of active liver
      disease.

PMID- 1029892
TI  - Acetate levels in human plasma.
AB  - We have developed a gas liquid chromatographic assay for plasma acetate which
      detects 0.01 mM and has a standard deviation of less than 16% of the mean at 0.05
      mM. The acetate concentration of venous blood obtained from normal subjects was
      0.025 +/- 0.002 mM. The value was not significantly different from the venous
      acetate concentration of dialysis patients, prior to a dialysis treatment. The
      acetate concentration of arterial plasma obtained from dialysis patients prior to
      a hemodialysis treatment was 0.048 +/- 0.006 mM. This was significantly greater
      than the venous concentration of 0.027 +/- 0.002 (p less than 0.01). This
      arteriovenous difference suggests that acetate is utilized peripherally. At the
      onset of hemodialysis, acetate concentrations rapidly rose and, in all but one
      case, reached a steady state value in the range of 1.5-5.1 mM. At the termination
      of dialysis, acetate concentrations fell rapidly, usually achieving baseline
      values within one hr. The rate of decrease was not a simple logarithmic function,
      suggesting that acetate metabolism is not solely a first order function.
      Furthermore, acetate disappearance was more rapid in the dialysis patients than
      in the normal subjects. We wish to emphasize that the present data, which were
      obtained on a small number of subjects are preliminary and should be interpreted
      with caution.

PMID- 1029893
TI  - Long-term minoxidil therapy in patients with refractory hypertension and renal
      disease.
AB  - Minoxidil, an orally effective vasodilator, was successful in lowering blood
      pressure in 22 patients, followed up for up to 3 yrs, with hypertension
      refractory to medical management, including both antihypertensive drug
      combinations and ultrafiltration. In nondialysis patients renal function was
      preserved and in dialysis patients bilateral nephrectomy was avoided. Although
      sodium retention and reflex tachycardia were common, they were managed by beta
      adrenergic blockade with propranolol and diuresis with furosemide.

PMID- 1029895
TI  - A new treatment of infected bovine graft arteriovenous fistulas.

PMID- 1029894
TI  - Long-term follow-up of bovine graft arteriovenous fistulas.

PMID- 1029896
TI  - Vascular access for dialysis: conversion of a scribner shunt to an arteriovenous
      fistula.

PMID- 1029897
TI  - A prospective study of the effectiveness of three permanent peritoneal catheters.

PMID- 1029899
TI  - Protection from hyperbaric oxygen intoxication by some derivatives of alpha
      detoglutaric acid.

PMID- 1029900
TI  - [Spontaneous pneumothorax caused by rapid decompression in conditions of natural
      or simulated altitude].

PMID- 1029901
TI  - [Clinico-functional data on the behavior of the cardiocirculatory system in
      members of a high-altitude mountain-climbing expedition].

PMID- 1029898
TI  - [Increase of neuropsychiatric diseases in the Armed Forces].

PMID- 1029902
TI  - [Usefulness of the Bales group interview in the study of some types of behavior].

PMID- 1029903
TI  - [Fear of flying].

PMID- 1029904
TI  - [Characterological selection. Doctrinary, deontological and practical problems].

PMID- 1029905
TI  - [Pneumothorax and flying personnel].

PMID- 1029906
TI  - The renal escape from the sodium retaining effect of mineralocorticoids in
      spontaneously hypertensive rats.
AB  - The effects of mineralocorticoids on urine and electrolyte excretion were studied
      in spontaneously hypertensive (SH) rats of Okamoto-Aoki strain and in
      normotensive white albino wistar strain rats. Sodium excretion fell from 0.568
      meq/day to 0.336 meq/day a reduction of 40%, on the 4th day of steroid
      administration in the SH rats whilst a 30% reduction was observed on the 6th day
      in normotensive rats whilst urine volumes were not significantly altered in both
      groups. Similarly, the phase of acute sodium retention was reversed (renal
      escape) earlier in the SH rats on the 7th experimental day when further
      administration of mineralocorticoids resulted in a two-fold increased in sodium
      excretion. Urine volumes were significantly increased during this phase. The
      pattern of response in SH rats differ significantly in time and magnitude from
      the normotensive controls. As the renal escape phenomenon is linked with
      extracellular volume regulation these results highlight the exaggerated
      sensitivity to increases in blood volume associated with genetic spontaneous
      hypertension.

PMID- 1029907
TI  - Metabolic activities and chemotherapy of Schistosoma mansoni.

PMID- 1029908
TI  - Biochemical studies of acetylcholine esterase inhibitor present in Eugenia
      caryophyllus.
AB  - Water, saline and ethanol extracts of Eugenia caryophyllus inhibited brain
      acetylcholinesterase (AchE) activity. Inhibitory action of the saline extract was
      greater than that of other extracts. The most active fraction of the saline
      extract obtained by chromatography through Sephadex G25 and DEAE cellulose
      columns and elution with tris and phosphate buffers (pH. 7.1) exhibited reactions
      characteristic of phenols, amino compounds and uronic acid. It is, therefore,
      suggested that the active inhibitor is a complex glycoside containing phenol and
      uronic acid part structure.

PMID- 1029909
TI  - Biological assay of Cassia podocarpa: a plant related to senna.
AB  - Leaves of the plant, Cassia podocarpa, were collected from Opah village near
      Accra, and dried. A suspension of the powdered leaf was given by gavage to groups
      of ten mice. A record was kept of the number of wet faeces passed in 24 hours.
      There was a linear relationship between the log dose of leaf and the number of
      wet faeces. The effect was maximal between 6 and 24 hours of administration and
      was larger than has been noted with senna.

PMID- 1029910
TI  - Peripheral nerve injuries from intramuscular injection of drugs.
AB  - 17 patients who were treated at the University of Nigeria Teaching Hospital for
      peripheral nerve paralysis resulting from intramuscular injection of drugs are
      analyzed. Ten of them were below the age of 5 years. Sciatic nerve was affected
      in 16 patients and only one patient had median nerve paralysis. Penicillin,
      ampicillin, tetracycline, paraldehyde and optalgin were some of the offending
      drugs. The prognosis was poor as only three patients achieved a partial recovery
      of function in the paralyzed nerves. With determination and public education,
      this iatrogenic tragedy could be eradicated.

PMID- 1029911
TI  - Nivaquine and urethral pain.
AB  - Two patients, one Jewish and the other Nigerian, were investigated for pain in
      the urethra. They were both fully treated along the usual lines without any
      change in the pain. The Jewish patient was later found to be sensitive to
      chloroquine. When ingestion of this drug was discontinued, his urethral pain
      disappeared after about four months. The Nigerian patient was advised along the
      same lines when it was found that he too took chloroquine for malarial attacks
      regularly. He had total symptomatic relief. The probable relationship between
      chloroquine and urethral pain is discussed.

PMID- 1029913
TI  - [Right- and left-ventricular myocardial biopsy in patients with congestive
      cardiomyopathy].

PMID- 1029912
TI  - Increase of electrocardiogram voltage and contractile force of the frog's heart
      induced by chloroquine.
AB  - The increase in the amplitude of the E.C.G. and ventricular contractile force
      induced by chloroquine sulphate was studied in frogs. It was shown that changes
      originated in the midbrain and were mediated through the sympathetic nervous
      system. The transmitter was recognized as a beta-adrenergic agent. The possible
      mechanism of action of chloroquine on the CNS responsible for the phenomenon
      observed was discussed.

PMID- 1029914
TI  - [Cardiac volume and hemodynamics (rest, exertion) in acquired cardiomyopathies].

PMID- 1029915
TI  - [Diastolic ventricular and myocardial elasticity in hyperthrophic-obstructive
      cardiomyopathy (HOCM)].

PMID- 1029916
TI  - [Vectorcardiographic studies in congestive cardiomyopathy].

PMID- 1029917
TI  - [Stress capacity and left-ventricular function in congestive cardiomyopathy].

PMID- 1029918
TI  - [Fatalities in hypertrophic obstructive myocardial disease].

PMID- 1029919
TI  - [Treatment of hypertrophic obstructive cardiomyopathy using verapamil].

PMID- 1029920
TI  - [Electrocardiographic changes in hereditary cardiomyopathy of the Syrian
      hamster].

PMID- 1029921
TI  - [Modification of hemodynamics in cardiac insufficiency using an imidazopyridine
      derivative].

PMID- 1029922
TI  - [Bacterial endocarditis: clinical aspects, therapy and course forms in 36
      patients].

PMID- 1029923
TI  - [Clinical picture of the idiopathic mitral valve prolapse syndrome (IMVP)].

PMID- 1029924
TI  - [Hemodynamics during rest and physical exertion in atrial septal defects].

PMID- 1029925
TI  - [Computer evaluation of hemodynamic parameters in aortic valve stenoses].

PMID- 1029926
TI  - [Heart valve replacement as an emergency].

PMID- 1029927
TI  - [Complication following mitral valve replacement in a long-term course].

PMID- 1029928
TI  - [Incidence of embolism following heart valve replacement].

PMID- 1029929
TI  - [Hemodynamic examinations following multiple heart valve replacements].

PMID- 1029930
TI  - [Direct effect of anti-arrhythmia agents on the tonus of isolated vessels].

PMID- 1029931
TI  - [Effect of dopamine on the fibrillary threshold of the feline heart].

PMID- 1029932
TI  - [Lidocaine therapy in the early phase of arrhythmia after acute myocardial
      infarct without influence on the fibrillatory threshold and on the spontaneous
      ventricular fibrillation of the heart].

PMID- 1029933
TI  - [Modification by drugs of anaphylactic arrhythmias in vitro].

PMID- 1029934
TI  - [Prevention of arrhythmias in acute myocardial infarct using the beta
      sympatholytic ICI 66082].

PMID- 1029935
TI  - [Regional elasticity of the cardiac muscle after experimental infarct].

PMID- 1029936
TI  - [Function of the mitochondria and contractile behavior in experimental pressure-
      and volume hypertrophy of the myocardium].

PMID- 1029937
TI  - [Studies on the hemodynamic determinants of cardiac output].

PMID- 1029938
TI  - [Potassium dependent ECG-changes in the animal-experiment hemodialysis].

PMID- 1029939
TI  - [Vasodilator treatment of chronic heart failure].

PMID- 1029940
TI  - [Influence of sodium nitroprusside on the performance parameters in patients with
      heart diseases].

PMID- 1029941
TI  - [Effect of dipyridamole on the metabolism of the human heart].

PMID- 1029943
TI  - [Regional myocardial perfusion and myocardial function--results of a new nuclear
      medicine procedure].

PMID- 1029942
TI  - [Myocardial oxygen consumption and coronary circulation under the influence of
      verapamil].

PMID- 1029944
TI  - [Cardiovascular risk factors in adolescents. 1st results of the Cologne-study
      1975/76].

PMID- 1029945
TI  - Coronary risk factor screening with maximal stress exercise testing in management
      personnel.

PMID- 1029946
TI  - [Medicamentous induction of an angina pectoris as a new test in the preliminary
      diagnosis of coronary heart disease (CHD)].

PMID- 1029947
TI  - [Transmural myocardial infarcts in angiographically normal coronary arteries-
      possible etiological role of oral contraceptives].

PMID- 1029948
TI  - [Intravital and postmortem morphometry on coronary arteries].

PMID- 1029949
TI  - [Comparative studies of coronary angiography and quantitative morphology of the
      coronary arteries (planimetry)].

PMID- 1029950
TI  - [Regional myocardial function after elapsed myocardial infarct].

PMID- 1029951
TI  - [Significance of the sagittal-planar vectorcardiogram for the diagnosis of heart
      infarct].

PMID- 1029952
TI  - [Clinical and biochemical findings in various course forms of recent myocardial
      infarct].

PMID- 1029953
TI  - [Discrimination of ischemic- and glycoside-conditioned ST-T segment changes in
      stress ECG].

PMID- 1029954
TI  - [Pulse-pressure products as a new standardization of stress. Results in healthy
      persons and patients with coronary disease].

PMID- 1029955
TI  - [Coronary circulation and myocardial O2 consumption in patients with coronary
      heart disease under isometric load and in maximal coronary dilatation].

PMID- 1029956
TI  - [Atrial frequency stimulation in comparison with stress ergometry in the
      diagnosis of latent coronary insufficiency].

PMID- 1029957
TI  - [Changes of plasma-catecholamine-level in the coronary sinus of patients with
      coronary heart disease under stress].

PMID- 1029958
TI  - [Myocardial liberation of inosine, hypoxanthine and lactate during atrial
      stimulation in coronary disease patients].

PMID- 1029959
TI  - [Arrhythmias following acute myocardial infarct. Comparison of the ambulatory and
      stationary phase].

PMID- 1029960
TI  - [Ventricular function and regional myocardial circulation in patients with
      coronary disease under sodium nitroprusside].

PMID- 1029961
TI  - [Is there a tachyphylaxis or drug resistance in the treatment of angina pectoris
      using nitro-bodies].

PMID- 1029962
TI  - [Hemodynamic effect of controlled home training as a long-term treatment of
      coronary insufficiency 6 and 12 months after the beginning of training].

PMID- 1029963
TI  - [Cardiological functional diagnosis in unclear syncopal attacks].

PMID- 1029964
TI  - [Echocardiographic findings in patients with Wolff-Parkinson-White syndrome].

PMID- 1029965
TI  - [Pre-excitation forms with normal PQ-interval and unobtrusive QRS-complex during
      sinus rhythm].

PMID- 1029966
TI  - [The antifibrillatory effect of mexiletine (Ko 1173) in experimentally induced
      myocardial infarct].

PMID- 1029967
TI  - [Interactions of triamterene and cardiac glycosides in the heart conduction
      system].

PMID- 1029968
TI  - [Differential effects of a new anti-arrhythmia agent (propafenon) on the Purkinje
      and myocardial activity filaments].

PMID- 1029969
TI  - [Effect of anti-arrhythmia agents on the stimulation threshold of implanted heart
      pacemakers].

PMID- 1029970
TI  - [Electrophysiological studies on the vulnerability of the human atrium].

PMID- 1029971
TI  - [Sinuventricular conduction times in the His-electrogram in graded physical
      stress conditions before and after beta-sympathicolysis].

PMID- 1029972
TI  - [Potentially dangerous adverse effects of anti-arrhythmia agents on the function
      of the sinus node].

PMID- 1029973
TI  - [Blood circulation times and heart-dynamic times before and after pacemaker
      implantation].

PMID- 1029974
TI  - [Time-dependent modification of hemodynamics through pacemaker-therapy].

PMID- 1029975
TI  - [Changes of the myocardial stimulation threshold of the human heart after probe
      implantation in relation to the type of used stimulation probe].

PMID- 1029976
TI  - [Clinical experiences with a new lithium pacemaker].

PMID- 1029977
TI  - [Studies on the basic blood pressure using Smirk's method, its relationship to
      location-dependent blood pressure values and to the "relaxation blood pressure"].

PMID- 1029978
TI  - [Hypertension in the early adult age--epidemiological study].

PMID- 1029979
TI  - [Extent of the stress blood pressure in 40-65-years-old persons with normal blood
      pressure, in treated and nontreated patients with hypertension].

PMID- 1029980
TI  - [Comparison of blood pressure reactions under stress in normotonic patients with
      and without an anamnesis of hypertension].

PMID- 1029981
TI  - [Aldosterone excretion, cortisol and corticosterone plasma concentration in
      patients with essential hypertension under sodium load].

PMID- 1029982
TI  - [Relationship between plasma-renin and plasma-aldosterone in patients with
      essential hypertension and in healthy persons].

PMID- 1029983
TI  - [Contraceptives, hypertension and nephrosclerosis].

PMID- 1029984
TI  - [Blood pressure behavior following 1-sar-8-ala-angiotensin II (saralasin) in
      essential and renovascular hypertension].

PMID- 1029985
TI  - [Diagnostic relevancy of saralasin in renin-dependent hypertension].

PMID- 1029986
TI  - [Clinical and experimental studies on the angiotensin inhibitor 1-sar-8-ile
      angiotensin II (P 165)].

PMID- 1029987
TI  - [Plasma dopamine-beta-hydroxylase during therapy with the beta-receptor blockader
      propranolol].

PMID- 1029988
TI  - [Effect of the beta receptor blockader propranolol (Dociton) on the plasma
      concentration of catecholamines in patients with hypertension].

PMID- 1029989
TI  - [Studies on the relationships between plasma-adrenaline, plasma-renin and the
      blood-pressure-lowering effect of the beta-receptor blockader ICI 66082
      (atenolol) in patients with essential hypertension].

PMID- 1029990
TI  - [Influence of propranolol on plasma-renin activity, plasma-aldosterone
      concentration and blood pressure in patients with essential hypertension].

PMID- 1029991
TI  - [Acute and chronic beta-receptor blockade: influence on blood pressure and on the
      renin-angiotensin-aldosterone system in essential hypertension].

PMID- 1029992
TI  - [Long-term treatment of essential hypertension using a beta-receptor blockader:
      effect on total-body-potassium and exchangeable sodium].

PMID- 1029993
TI  - [Chronic treatment of severe hypertension using minoxidil, propranolol and
      diuretics].

PMID- 1029994
TI  - [Problems in the therapy of obesity].

PMID- 1029995
TI  - The study of energy metabolism in obese patients.

PMID- 1029996
TI  - [Possibilities of diet therapy in obesity].

PMID- 1029997
TI  - [Treatment of obesity through total fasting].

PMID- 1029998
TI  - [Problems in the therapy of obesity low carbohydrate, relatively fat-rich diet:
      biochemical findings].

PMID- 1029999
TI  - [Problems in the therapy of obesity. Low carbohydrates, relatively fat-rich diet:
      clinical findings].

PMID- 1030000
TI  - [Significance of filling- and swelling-substances in the diet therapy of
      obesity].

PMID- 1030001
TI  - [Psychosomatic problems in the treatment of obesity].

PMID- 1030002
TI  - [Appetite-behavior of obese patients. Conditions and consequences for therapy].

PMID- 1030003
TI  - [The problem of drug therapy in obesity].

PMID- 1030004
TI  - [Thyroid hormones in obesity. Further onset-points for hormonal therapy].

PMID- 1030005
TI  - [Surgical treatment of obesity].

PMID- 1030006
TI  - [Internal medicine complications after intestinal bypass-surgery].

PMID- 1030007
TI  - [Metabolism--obesity. Long-term results of total fasting comparing ambulatory and
      stationary patients].

PMID- 1030008
TI  - [Long-term results of fasting therapy].

PMID- 1030009
TI  - [Short- and long-term results of a combination of zero-diet and exercise therapy
      in high-degree obesity].

PMID- 1030010
TI  - [Long-term study on 680 obese persons after short-term or contrast ambulatory
      care using a low carbohydrate and protein-rich diet].

PMID- 1030011
TI  - [Long-term experiences with a computer-assisted reducing-diet program].

PMID- 1030012
TI  - [Treatment of obesity in school-children and adolescents using a low calorie diet
      consisting of freely selected food].

PMID- 1030013
TI  - [Influence of sport and diet on the body weight of obese pre-puberal children].

PMID- 1030014
TI  - [Glucose tolerance and size of the fat cell in obese children before and after
      weight reduction].

PMID- 1030015
TI  - [New anthropometric data of 7000 children aged 4-16 years].

PMID- 1030016
TI  - [Energy metabolism in the heart of uremic animals].

PMID- 1030017
TI  - [Studies on the behavior of liver glycogen in uremia].

PMID- 1030018
TI  - [Effect of high-molecular urine fractions of healthy persons and patients with
      uremia on the rate of gluconeogenesis in kidney cortex slices of the rat].

PMID- 1030019
TI  - [Prostaglandin-induced natriuresis in acute expansion of the extracellular
      volume].

PMID- 1030020
TI  - [Separation of bone-marrow-toxic factors from high molecular urine fractions of
      healthy persons and patients with uremia through dialysis in a desaggregated
      system].

PMID- 1030021
TI  - [Morphological studies on diabetic nephropathies in the rat (model for human
      glomerulopathy?)].

PMID- 1030022
TI  - [Demonstration of enzymatically active membrane portions of proximal kidney
      tubules in the urine of patients with cholestasis].

PMID- 1030023
TI  - [Changes of the vascular tree of the kidney in experimental pyelonephritis].

PMID- 1030024
TI  - [Transposition of the kidney function in persons with obesity under strict
      fasting].

PMID- 1030025
TI  - [Progressive continuing glucose titration for the recording of tubular glucose
      resorption capacity in various kidney diseases].

PMID- 1030026
TI  - [Hypercalciuria in patients with oxalate-calculi: suppression of parathyroid
      glands through the intestinal hyperabsorption of calcium].

PMID- 1030027
TI  - [Balkan nephropathy].

PMID- 1030028
TI  - [Pathological reaction of the adenyl-cyclase-cAMP-system on the glucagon dosage
      in uremia].

PMID- 1030029
TI  - [Aortic insufficiency in terminal renal insufficiency].

PMID- 1030030
TI  - [Successful treatment of renal insufficiency in primary malignant
      nephrosclerosis].

PMID- 1030031
TI  - [Determination of vitamin B 12 in patients with chronic kidney failure].

PMID- 1030032
TI  - [Hypercalcemic crises in patients with chronic kidney failure due to calcium
      containing ion-exchangers, antacids and other drugs].

PMID- 1030033
TI  - [Differential behavior of plasma-renin activity in terminal renal insufficiency
      under stimulation and suppression conditions].

PMID- 1030034
TI  - [Potassium-saving effects of amiloride, triamterene and spironolactone].

PMID- 1030035
TI  - [Renal effects of diuretics in acute kidney failure].

PMID- 1030036
TI  - [Micropunctures and clearance studies on the effect of furosemide in limited
      kidney function].

PMID- 1030037
TI  - [Pharmacodynamics of a diuretically effective pyrazoline derivative in kidney
      failure].

PMID- 1030038
TI  - [Effect of osmadizone on serum uric acid as well as on renal uric acid, oxypurine
      and orotic acid excretion in healthy subjects].

PMID- 1030039
TI  - [Effect of the betamimeticum fenoterol on the renal transport of water and
      electrolytes as well as on plasma renin and plasma aldosterone in normal persons,
      pregnant women and patients with uremia].

PMID- 1030040
TI  - [Digitoxin level in terminal renal insufficiency].

PMID- 1030041
TI  - [Experiences with short-term dialysis].

PMID- 1030042
TI  - [Comparative studies on the effect of sodium chloride or liquids on the blood
      pressure of patients under a chronic hemodialysis program].

PMID- 1030043
TI  - [Osteopenia as a late complication of renal osteopathy--incidence, course and
      therapeutic methods].

PMID- 1030044
TI  - [Effect of serum phosphate on the oxygen binding to hemoglobin. Studies on
      patients under hemodialysis].

PMID- 1030045
TI  - [Hemodynamic studies in patients under long-term hemodialysis].

PMID- 1030046
TI  - [Rapid progressive glomerular insufficiency--course observation under
      hemodialysis and immunosuppression].

PMID- 1030047
TI  - [Need-adapted heparinization in hemodialysis].

PMID- 1030048
TI  - [Protein deficiency in peritoneal dialysis].

PMID- 1030049
TI  - [Dual nature of leukemic cells in hairy-cell leukemia].

PMID- 1030050
TI  - [Proliferation kinetics of blasts from the peripheral blood of patients with
      acute leukemia cultured in diffusion-chambers].

PMID- 1030051
TI  - [Additional experiences in the treatment of acute leukemias in the sterile
      laminar down-flow tents and in single rooms].

PMID- 1030052
TI  - [Effect of the pre-treatment of granulocyte donors with prednisolone on the in
      vitro functions of granulocytes].

PMID- 1030053
TI  - [Experimental and clinical experiences on plasmapheresis using blood-cell
      separators].

PMID- 1030054
TI  - [Plasma cell leukemia. Report of 5 cases].

PMID- 1030055
TI  - [Polyglobulia with increased secretion of erythropoietin in pheochromocytoma].

PMID- 1030056
TI  - [Reduced glutathione and enzyme activities in erythrocytes of various again
      myeloproliferative diseases].

PMID- 1030057
TI  - [Functional and ultrastructural study on membrane-stabilized blood platelets
      during the course of preparation, preservation and transfusion].

PMID- 1030058
TI  - [Electrophoretic characterization of lymphocytes from patients with chronic
      lymphatic leukemia].

PMID- 1030059
TI  - [Immune complexes in the serum of patients with leukemia].

PMID- 1030060
TI  - [Herpes zoster in splenectomized patients with Hodgkin's disease].

PMID- 1030061
TI  - [Microrheologic behavior of plasma cell dyscrasia].

PMID- 1030062
TI  - [Primary change in the form of blood platelets and thrombocyte aggregation after
      blood withdrawal].

PMID- 1030063
TI  - [Enzyme activities in thrombocytes of various density in subjects with normal and
      elevated thrombocyte count].

PMID- 1030064
TI  - [Direct proteolysis of coagulation factors through granulocyte enzymes as a
      possible mechanism of blood coagulation disorders in acute leukemia and
      septicemia].

PMID- 1030065
TI  - [The effect of endotoxin on the coagulation activity of leukocytes].

PMID- 1030066
TI  - [Importance of thrombocytes and leukocytes in the release of intravascular
      coagulation by endotoxin].

PMID- 1030067
TI  - [In-vivo studies on the elimination of various soluble fibrin-preparations].

PMID- 1030068
TI  - [Congenital dysfibrinogenemia: fibrinogen Giessen II].

PMID- 1030069
TI  - [Fibrin structure in hepatitis and liver cirrhosis].

PMID- 1030070
TI  - [Factor VIII associated protein and cold-insoluble globulin in leukemias and
      tumors].

PMID- 1030071
TI  - [Use of the cell-separator in the treatment of factor-VIII-inhibitor hemophilia].

PMID- 1030072
TI  - [Use of blood-cell separators for the preparation of platelet concentrates and
      their evaluation through the determination of survival time].

PMID- 1030073
TI  - [Elimination of digitoxin in liver diseases].

PMID- 1030074
TI  - [Distribution and elimination of digitoxin in patients with limited kidney
      function].

PMID- 1030075
TI  - [New results of studies on the choice of cardiac glycosides for patients under
      dialysis].

PMID- 1030076
TI  - [Cardiac glycosides and uremia].

PMID- 1030077
TI  - [Plasma glycoside level and electric excitability of the heart atria under the
      influence of digitalis glycosides].

PMID- 1030078
TI  - [Experimental and clinical findings on treatment of cardiac-glucoside
      intoxication].

PMID- 1030079
TI  - [Behavior of the erythrocyte electrolytes as a parameter of the digoxin plasma
      level].

PMID- 1030080
TI  - [Pharmacokinetics and clinical experiences with a new aminoglycoside
      antibioticum: amikacin].

PMID- 1030081
TI  - [Studies on the determination of urinary N-acetyl-p-aminophenol].

PMID- 1030082
TI  - [Plasma level of pindolol (Visken) under long-term treatment, computed from
      pharmacokinetics after a single dose].

PMID- 1030083
TI  - [Pharmacokinetic behavior of verapamil in man].

PMID- 1030084
TI  - [Course of blood level and urinary elimination of digoxin in massive digitalis
      intoxications].

PMID- 1030085
TI  - [Comparative examinations of serum-glycoside concentrations in glycoside
      intoxications with extracardiac adverse effects after intake of beta
      methyldigoxin, beta-acetyldigoxin and digoxin].

PMID- 1030086
TI  - [Glycoside-plasma level under maintenance therapy--dispersion of the
      concentrations and its causes].

PMID- 1030087
TI  - [Significance of body weight in the digitalization of the patients with heart
      diseases].

PMID- 1030088
TI  - [Significant plasma digoxin concentration in patients at the time of hospital
      admission].

PMID- 1030089
TI  - [Relationship between incidence of suspected digitalis intoxication adverse
      effects and size of digoxin level in stationary patients].

PMID- 1030090
TI  - [Studies on the elimination of digoxin and beta-methyldigoxin].

PMID- 1030091
TI  - [Relationship between the fading of the digoxin effect in the stress
      electrocardiogram with pharmacokinetic parameters].

PMID- 1030092
TI  - [Effect of digoxin on the stress ECG in healthy persons].

PMID- 1030093
TI  - [Studies on the pharmacokinetics of digoxin in patients with hyperthyroidism].

PMID- 1030094
TI  - [Oncogenesis due to immunosuppressive agents (cytostatics) in (NZBxNZW) mice].

PMID- 1030095
TI  - [Simulation of acute leukemia by bone-marrow carcinosis].

PMID- 1030096
TI  - [Metabolism of benzpyrene: inter-individual differences in man and
      cancerogenicity].

PMID- 1030097
TI  - [Serum sialytransferase activity in the diagnosis of malignoma].

PMID- 1030098
TI  - [Significance of the radioimmunologic determination of carcinoembryonic antigen
      in the diagnosis and course control of malignant tumors].

PMID- 1030099
TI  - [Hypercoagulability in patients after heart infarct and malignant tumors].

PMID- 1030100
TI  - [Experimental results with antitumor immune-RNA].

PMID- 1030101
TI  - [Pneumonia due to paraffin oil: specific demonstration and quantitative course
      control of expectorated paraffin oil during various phases of treatment during an
      observation period of 120 days].

PMID- 1030102
TI  - [In-vitro diagnosis of bronchial asthma].

PMID- 1030103
TI  - [Function of respiratory muscles in patients with chronic obstructive lung
      diseases under static conditions].

PMID- 1030104
TI  - [Determination of the anatomic respiratory dead space inspiration by inspiration
      in patients with lung diseases using a new method of measurement].

PMID- 1030105
TI  - [Respiratory gas exchange in a linear increased submaximal unsteady state load].

PMID- 1030106
TI  - [Studies on the gravitation-dependent blood circulation distribution in  the lung
      by means of double-nuclide perfusion scintigraphy].

PMID- 1030107
TI  - [Indications of stenoses in the large respiratory ways by means of total body
      plethysmography].

PMID- 1030108
TI  - [Determination of the diffusion resistance of the alveo-capillary membrane and
      intracapillary blood volume of the lung using the automatic analysis of CO
      transfer in patients with heart diseases].

PMID- 1030109
TI  - [Influence of weight reduction on various ventilation values in obese patients].

PMID- 1030110
TI  - [Influence of terbutaline on the heart-rate volume and pulmonary artery-pressure
      in transition from normoxia to hypoxia in patients with obstructive ventilation
      disorder].

PMID- 1030111
TI  - [Comparison of the immunosuppressive effects of 6-mercaptopurine, azathioprine,
      cyclophosphamide and 036.5122 (Asta) on primary and secondary immune reactions in
      the mouse].

PMID- 1030112
TI  - [Studies on the mode of action of D-penicillamine on lymphocytes].

PMID- 1030113
TI  - [Therapy using the transfer factor in combined immunologic deficiency syndromes].

PMID- 1030114
TI  - [Partial characterization of the colony stimulating activity (CSA) from human
      leukocyte cultures].

PMID- 1030115
TI  - [Effect of levamisole on IgG- and C3- receptor activity and the function of human
      blood monocytes in vitro].

PMID- 1030116
TI  - [Leukocyte migration inhibition test in the diagnosis of Boeck's disease].

PMID- 1030117
TI  - [Leukopenia and lymphocytotoxic autoantibodies (LA)].

PMID- 1030118
TI  - [Humoral and cellular phenomena after intake of Venopyronum-dragees (pseudo-LE
      syndrome)].

PMID- 1030119
TI  - [Clinical significance on the demonstration of inhibition factors in the sera of
      patients with acute and chronic hepatitides].

PMID- 1030120
TI  - [Studies on the lymphocyte toxicity in acute and chronic hepatitides].

PMID- 1030121
TI  - [Autoimmunity, HBsAg and HLA in patients with chronic active hepatitis (CAH)].

PMID- 1030122
TI  - [Immunological examination procedures as a diagnostic tool in gluten
      enteropathy].

PMID- 1030123
TI  - [Cellular immune reactions in patients with malignant tumors: correlation of
      phytohemagglutinin-induced lymphocyte transformation and epicutanous tests using
      dinitrofluorobenzene].

PMID- 1030124
TI  - [Enzymatic DNA synthesis and transformation of peripheral lymphocytes in chronic
      renal insufficiency].

PMID- 1030125
TI  - [Influence of thyroxine on the 2,3-DPG content of erythrocytes in vivo and in
      vitro].

PMID- 1030126
TI  - [Modification of various parameters of fat metabolism and the hypophyseal
      hypothalamic regulation through therapeutic doses of d-triiodothyronine].

PMID- 1030127
TI  - [TSH-secretion, thyroxine- and triiodothyronine concentrations under D-thyroxine
      administration].

PMID- 1030128
TI  - [Extrathyroid-induced changes of serum triiodothyronine levels].

PMID- 1030129
TI  - [Threshold situations of hyperparathyroidism: ectopic location of adenoma and
      paraneoplastic secretion of the parathyroid hormone].

PMID- 1030130
TI  - [Corticosterone content in the plasma and adrenal glands of rats after treatment
      with chlorphentermine].

PMID- 1030131
TI  - [Endogenous steroid balance under treatment with spironolactone].

PMID- 1030132
TI  - [Effect of apomorphine on the secretion of prolactin in florid acromegaly].

PMID- 1030133
TI  - [Surgical and medicamentous treatment of pituitary tumors producing prolactin].

PMID- 1030134
TI  - [Experiences with the synthetic vasopressin derivative 1-desamino-8-D-arginine
      vasopressin (DDAVP) in the therapy of diabetes insipidus].

PMID- 1030135
TI  - [Radioimmunologic determination of urinary vasopressin in patients with
      hypertension and lung neoplasms].

PMID- 1030136
TI  - [Therapy of the diabetic metabolic condition in hyperprolactinemias and
      acromegaly].

PMID- 1030137
TI  - [Functional diagnostic studies of testosterone and gonadotropin secretion in
      relation to the stage of kidney insufficiency].

PMID- 1030138
TI  - [Effect of liver and testicular functions on the biologic availability of
      testosterone in various dosage forms].

PMID- 1030139
TI  - [Clinically latent arterial disease of the leg in patients with coronary heart
      disease].

PMID- 1030140
TI  - [Effect of tobacco-smoke and carbon monoxide on thrombocyte aggregation and
      adhesiveness in vivo in the miniature pig].

PMID- 1030141
TI  - [Echographic determination of arterial elasticity in vivo in juvenile diabetics,
      patients with hypertension and persons with healthy blood circulation].

PMID- 1030142
TI  - [Intra-arterial therapy of peripheral arterial occlusive disease with oxyfedrine
      and low-molecular dextran].

PMID- 1030143
TI  - [Digitalis therapy in arterial occlusive diseases].

PMID- 1030144
TI  - [Comparative studies on the antithrombotic effect of acetylsalicylic acid and
      anticoagulants on an experimental model of thrombosis].

PMID- 1030145
TI  - [Experience with urokinase in chronic arterial occlusive disease and long
      standing phlebothrombosis].

PMID- 1030146
TI  - [Peripheral lymphangiopathies--15-year follow up].

PMID- 1030147
TI  - [New possibilities in the treatment of paraquat or diaquat poisoning: intestinal
      lavage and hemoperfusion].

PMID- 1030148
TI  - [Hemoperfusion in severe hypnotic-poisoning].

PMID- 1030149
TI  - [Hemoperfusion--calculated risk].

PMID- 1030150
TI  - [Prognosis of patients with pulmonary edema].

PMID- 1030151
TI  - [Hemodynamic effects of external counterpulsation].

PMID- 1030152
TI  - [Comparative studies on continuing intra-arterially and transcutaneously measured
      partial oxygen consumption in patients under intensive care].

PMID- 1030153
TI  - [Increase of the urine-time volume through glucose-insulin in cardiogenic shock].

PMID- 1030154
TI  - [Clinico-toxicological studies using a combination gas chromatography--mass
      spectrometry (GC-MS)].

PMID- 1030155
TI  - [Modification of experimental etiocholanolone fever through indomethacin].

PMID- 1030156
TI  - [Results of comprehensive preventive medical check-ups in 1369 persons].

PMID- 1030157
TI  - [Registration and evaluation of pathologico-anatomical diagnoses in 1395
      autopsies of 80-102-year-old men and women].

PMID- 1030158
TI  - [The behavior of dying patients].

PMID- 1030159
TI  - [Etiopathogenesis of portal hypertension].

PMID- 1030160
TI  - [Diet therapy of diabetes mellitus].

PMID- 1030161
TI  - Mechanism of bilirubin transfer into the liver.

PMID- 1030162
TI  - Pathogenesis of different types of jaundice.

PMID- 1030163
TI  - The effect of allyloestrenol on human chorionic somatomammotropin synthesis of
      the placenta during normal pregnancy.
AB  - The effect of allyloestrenol on human chorionic somatomammotropin (HCS) level in
      healthy pregnant women in the fifth to eighth months of gestation has been
      studied by radioimmune techniques. The HCS level showed a significant increase
      within 10 to 12 days. According to the results, allyloestrenol exerts a
      stimulating effect on the placental steroids as well as on HCS production.

PMID- 1030164
TI  - Fatal BCG vaccination.
AB  - A female baby 7 weeks of age developed a fatal tuberculous disease following BCG
      vaccination. The infant had Swiss type agammaglobulinaemia, associated with oral
      thrush, pneumonitis, umbilical infection and chronic enteritis not responding to
      any treatment. Post mortem revealed an aplasia of the thymus, hypoplasia of the
      lymph system, miliary tuberculous foci in the lymph nodes, liver and spleen.

PMID- 1030165
TI  - Mucoviscidosis: total amylase activity of serum and mixed saliva in homozygous
      and heterozygous subjects.
AB  - Total amylase activity of serum and mixed saliva was studied in homozygotes and
      heterozygotes for mucoviscidosis and in healthy subjects. Mean serum total
      activity was 269.0 +/- 113.7 U/l in the homozygotes, exceeding in nearly 50% of
      the cases the values given in the literature and those observed in the normal
      controls. The difference against the control group was significant (P less than
      0.05). Mean serum total amylase activity of heterozygotes agreed with the mean
      value for the healthy group (203.5 +/- 79.5 U/l) without a significant
      difference. Total amylase activity in the saliva of homozygotes (148.700 +/-
      65.700  U/l) was higher than in the heterozygotes /118.300 +/- 74.200 U/l) of the
      healthy children (51.700 +/- 26.500 U/l). The difference between the homozygous
      and healthy groups was strongly significant (P less than 0.01), and that between
      the heterozygous group and the combined healthy children and adult groups was
      also significant (P less than 0.05). In the heterozygotes, salivary amylase
      activity was slightly elevated but not significantly different from the control
      group and did not result in a change in serum total amylase activity.

PMID- 1030166
TI  - Antepartum glucocorticoid treatment: the effect of prednisolone on umbilical
      blood glucose, plasma free fatty acids and individual free amino acid levels.
AB  - Blood glucose, plasma free fatty acid and individual free amino acid levels were
      measured in the cord blood of preterm newborns whose mothers had received
      prednisolone treatment to prevent RDS. No significant differences were found in
      either of the metabolites between the prednisolone treated and the control group
      of comparable gestational age and birth weight. The results suggest that
      corticosteroid treatment has no gross adverse effect on fuel homeostasis.

PMID- 1030167
TI  - Prevention of respiratory distress syndrome by antenatal maternal steroid
      treatment.
AB  - A total of 107 women at risk of premature delivery received antepartum 45 to 60
      mg prednisolone medication. Their babies were matched with comparable neonates of
      untreated mothers. The frequency of respiratory distress syndrome was 6/107 in
      the steroid-treated, and 33/107 in the control group. No maternal complications
      were seen. Neonatal mortality was lower in the pretreated group in which,
      however, a higher number of bronchopneumonia was observed. In 58 prednisolone
      treated women labour could be delayed, and their infants were born at term. No
      stillbirth or intrauterine growth retardation occurred among them.

PMID- 1030168
TI  - Chloride ion concentration in vaginal discharge and urine during puberty.
AB  - In 27 prepubertal-pubertal girls the chloride ion concentration in vaginal
      discharge and urine was estimated four times during the menstrual cycle by means
      of a direct new micromethod using a Cl-selective electrode. In pubertal girls the
      chloride content showed changes both in vaginal discharge and in urine; the
      latter changed practically parallel with the vaginal value. A sharp rise in
      chloride content characteristic of normal ovulation was observed in 5 patients
      free from hormonal disturbances, while there were significant differences during
      ovulation 5 times and in the premenstrual phase 6 times in the girls with
      hormonal disturbances.

PMID- 1030169
TI  - [Saccular aneurysm of the A. cerebri media operated in infancy].

PMID- 1030170
TI  - Effects of thyroid-stimulating hormone upon the regulation of serum insulin
      levels and on the blood sugar and serum free fatty acid responses to insulin
      [author's transl].
AB  - The effect of a chronic treatment with thyroid-stimulating hormone on the blood
      sugar, serum insulin and free fatty acid responses to exogenous insulin in dogs
      was studied comparatively. Either before or after thyroid-stimulating hormone
      treatment, the blood sugar levels were significantly below- and serum
      immunoreactive insulin above- their respective base line throughout the test. The
      blood sugar basal value was raised by the treatment, while the blood sugar levels
      at any time during the test were not affected. Neither were their respective
      serum insulin values, nor serum insulin base line. The rate of disappearance of
      exogenous insulin from blood was not affected either, and insulin space was
      hardly, significantly increased. Hypoglycaemia induced a mobilization of free
      fatty acids from lipid stores, which was more intense and prolonged after thyroid
      stimulating treatment. These results are discussed, emphasizing the weak
      lipomobilizing effect of thyroid-stimulating hormone in this species, as well as
      taking into consideration the mild participation of an extra-pancreatic mechanism
      such as insulin space in the regulation of serum insulin levels in normal dogs as
      modified by thyroid-stimulating hormone.

PMID- 1030171
TI  - Steroid metabolism in rat submaxillary glands.
AB  - The ability of rat submaxillary gland to metabolize C21 steroids was studied by
      culturing explants with labeled progesterone, pregnenolone and 17 alpha
      hydroxyprogesterone. The metabolites isolated were identified by paper
      chromatography, thin layer chromatography and combined gas liquid chromatography
      mass spectrometry. The radiochemical purity of certain metabolites was confirmed
      by recrystallization to constant specific activity. The capability of this gland
      to reduce C21 steroids was confirmed with the isolation of 3 alpha-hydroxy-5
      alpha-pregnan-20-one and 5 alpha-pregnane-3 alpha, 20 beta-diol. The presence of
      delta 5, 3 beta hydroxy steroid dehydrogenase was shown by the conversion of
      pregnenolone to progesterone. Only in the incubations with 17 alpha
      hydroxyprogesterone a compound with a molecular weight 290 was detected.

PMID- 1030172
TI  - Cardiovascular  reactivity in hypertension due to unilateral renal artery
      stenosis before and after contralateral nephrectomy.

PMID- 1030173
TI  - A depressant cortical reaction induced by afferent stimulation.
AB  - A depressant reaction of the electrocortical activity of the brain cortex is
      described. The changes consist in decrease in the amplitude and frequency of the
      basal waves of the electrocorticogram together with the appearance of slow waves
      similar to those of the sleep state. The results are more clear upon the
      dendritic action potentials induced by the topical application of strychnine or
      mescaline. They include a rise in the threshold to the electrical stimulation
      applied to elicit these potentials together with a lengthening of their
      latencies. The depressant effects were obtained by low threshold vagal, carotid
      sinus, low threshold sciatic and tactile afferent stimulation. Similar depressant
      effects were produced by serotonin (5-HT) topically applied. The effects of
      afferent stimulation were reduced in magnitude by an intracisternal injection of
      5,6-dihydroxytryptamine. A serotonergic mechanism acting in a diffuse, humoral,
      way is postulated. The methodological importance of studying the strychnine or
      mescaline spikes is emphasized.

PMID- 1030174
TI  - The effect of drugs containing -SH and -S-S- groups on the stability of mouse
      liver lysosomes.

PMID- 1030175
TI  - Intestinal pathology in a freshwater teleost, Channa punctatus (bloch) exposed to
      sub-lethal and chronic levels of three organophosphorus insecticides.

PMID- 1030176
TI  - Effect of hypobaric hypoxia on erythrocytic glycolysis and 2,3 - DPG in rodents.
AB  - Glycolytic activity of red cells was determined in mice, rats and rabbits
      submitted to 4 700 and/or 6 000 m simulated altitude for variable periods of time
      and in controls at sea level. In all the species studied, glycolysis was found to
      be increased by the third week of exposure. 2,3-diphosphoglycerate (DPG) content
      was measured in rats submitted to simulated altitude for 4 to 66 days. A highly
      significant increase, which was higher at 4 700 than at 6 000 m, was found from
      the first days of exposure and throughout the whole experimental period. Our
      results are consistent with the hypothesis that variable DPG changes in different
      degrees of hypoxia are related to its ability to increase oxygen release to the
      tissues and negatively correlated with hematocrit increase. The data show that
      the increase in red cell glycolysis is only a temporary effect of relatively
      severe hypoxia, not related with changes in DPG concentration.

PMID- 1030177
TI  - Programmed stimulator for threshold of action potential.
AB  - A programmed digital stimulator is described, in which the pulse generator can be
      regulated in frequency and duration. The output pulses amplitude increases
      automatically by increments under 5% of the previous step, sequence which allows
      a much better approximation to the threshold value of action potential. A
      photographic camera is synchronized for recording. The power supplies, pulse
      duration generator, binary counter, converter, pulse control, and detector
      circuits are given in detail.

PMID- 1030178
TI  - Effect of syngeneic RNA pretreatment on the growth of an allogeneic mouse tumor.

PMID- 1030179
TI  - [Phenomenology of memory and its changes].

PMID- 1030180
TI  - [Late dyskenetic neuroleptic syndrome (persistent dyskinesia). Apropos of 2
      cases].

PMID- 1030181
TI  - Characterization of the biochemical mechanism of action of alpha-(N)-heterocyclic
      carboxaldehyde thiosemicarbazones.

PMID- 1030182
TI  - Adenosine metabolism in cultured lymphoid cells.

PMID- 1030183
TI  - Synthesis of small polynucleotide chains in human lymphoblasts pretreated with
      methotrexate: A possible mechanism for DNA chain growth.

PMID- 1030184
TI  - Insulin, glucagon, and the liver.

PMID- 1030185
TI  - Regulation of succinate dehydrogenase: does the membrane environment change the
      catalytic activity of the enzyme?

PMID- 1030186
TI  - Genetic differences in the metabolism of carcinogens and in the binding of benzo
      (a) pyrene metabolites to DNA.

PMID- 1030187
TI  - Gene interactions in germ differentiation of Drosophila.

PMID- 1030188
TI  - Allosterism, regulation and cooperativity: the case of ribonucleotide reductase
      of Lactobacillus leichmannii.

PMID- 1030189
TI  - The role of pharmacology in the education of health-care professionals
      (pharmacy).

PMID- 1030190
TI  - Terminal behavioral objectives for teaching clinical toxicology to clinical
      pharmacists.

PMID- 1030191
TI  - Clinical pharmacokinetics--its impact on instruction in clinical pharmacy and
      pharmacology.

PMID- 1030192
TI  - Clinical pharmacokinetic service and research--present status and future goals at
      SUNY-Buffalo.

PMID- 1030194
TI  - Evaluation of students in the clinical setting.

PMID- 1030193
TI  - Physical parameters for monitoring patient care--a new direction in clinical
      pharmacy education.

PMID- 1030195
TI  - Directions in clinical pharmacy research.

PMID- 1030196
TI  - The use of uselessness of the pharmacology laboratory in teaching pharmacology.

PMID- 1030197
TI  - The graduate training program in pharmacology at the University of Kansas School
      of Pharmacy.

PMID- 1030198
TI  - The graduate program in pharmacology at the Ohio State University College of
      Pharmacy.

PMID- 1030199
TI  - A Master of Science degree in (clinical) pharmacology at the University of the
      Pacific.

PMID- 1030200
TI  - Ambivalence as a sociological explanation: the case of cultural explanations of
      alcohol problems.

PMID- 1030201
TI  - Violent acts and violent times: a comparative approach to postwar homicide rates.

PMID- 1030202
TI  - Esterases in Biomphalaria glabrata (Mollusca: Pulmonata), characterization,
      polymorphism, inheritance pattern and interspecific differences.

PMID- 1030203
TI  - [Effect of the sinus gland on the quantity of tegmentum carotenoid pigments in
      Palaemon serratus (Pennant, 1777) Crustacea, Decapoda macrura. Comparative
      study].

PMID- 1030204
TI  - Studies on liposomes.

PMID- 1030205
TI  - Spectral changes of nucleic acids and nucleotide solutions at the 190-220nm
      region.
AB  - Nucleic acids and nucleotide solutions have between 190 and 220 nm an hypo
      bathochromic effect electrostatistically induced by acylic groups or by effective
      binding of several substances. In the former case, with DNA or RNA, the effect
      reverts through gel filtration and dialysis. In the latter case no reversion
      occurs. This is proposed as a probe for complex formation with the nucleic acid
      bases. Thermal denaturation of DNA solutions gives to the above mentioned
      maximum, an hyperchromicity somewhat different from the usually obtained at 260
      nm.

PMID- 1030206
TI  - Genetic variation in two natural populations of Biomphalaria tenagophila:
      esterases and alcohol dehydrogenase.
AB  - The polymorphism of two natural populations of snails, Biomphalaria tenagophila,
      from Sao Jose dos Campos, Sao Paulo State (SJ) and from Nucleo Bandeirante,
      Distrito Federal (BN), was studied with respect to esterase and alcohol
      dehydrogenase (ADH) zymograms. The two population zymograms do not differ
      qualitatively. However the high frequency of esterase a and b bands in SJ and of
      e,f and h in NB, is a diagnostic mark. Moreover, frequency of band e alone can be
      used to distinguish the two populations. The high frequency of 3-banded ADH
      phenotype is a diagnostic mark of the SJ population.

PMID- 1030207
TI  - The role of the glucose-6-phosphate in the phosphorylase b kinase activation
      found in perfused rat hearts treated by dinitrophenol.
AB  - In order to explain the phosphorylase b kinase activation found in perfused rat
      hearts treated by dinitrophenol, the glucose-6-phosphate levels and the enzyme
      activity were determined. Experiments were also done to determine the
      phosphorylase b kinase inhibition by the ester. The low glucose-6-phosphate
      levels and the enzyme inhibition found, suggested that the phosphorylase b kinase
      is activated by a mechanism that involves phosphofructokinase.

PMID- 1030208
TI  - [Nitrates in soil and water].

PMID- 1030209
TI  - [Denitrification of waters on the way from surface to underground levels in a
      karstic area].
AB  - The failure of the biological processes of waters' recycling in their passing
      through the soil occurs more and more frequently in calcareous areas. This led us
      to consider the problem of conditions necessary to the good development of the
      biological activity. This uses enzymatic reactions activated by chemical elements
      in very low concentrations: the oligo-elements. The experimental study, in
      drainage basin in a calcareous area, consisted in finding the percentage of oligo
      elements in the waters, in the soils and in the parent rocks. This allowed us to
      draw a map of the probable lack of oligo-elements and thus to foresee the
      vulnerability of phreatic waters.

PMID- 1030210
TI  - [Nitrate accumulating capability of some market garden vegetables].
AB  - Nitrate accumulation in plant is essentially function of the amount of nitrate
      nitrogen present in the substrate. That can be provided by mineral fertilizers or
      by organic manure. Due to the amount of nitrogen fertilizers needed in order to
      obtain sufficient yields the presence of nitrate is a general phenomenon in
      vegetable. Nevertheless the distribution of nitrate ions in the different parts
      of the plant influences the importance of the accumulation in the different kinds
      of vegetable. The experiments reported showed that leaves contain more nitrate
      ions than roots and roots more than fruit. The results obtained in soilless
      culture on lettuces, tomatoes and egg-plant demonstrated that the amount of
      accumulated nitrate is also dependent on the equilibrium between the different
      ions in the nutrient solution. Ammonium, potassium, sulfate and molybdenum have
      been shown to influence the rate of nitrate accumulation in the different
      species. It appears that it is not possible to obtain vegetable without nitrate,
      but it is possible, by an equilibrated fertilization, to reduce the amount
      accumulated in the tissue.

PMID- 1030211
TI  - [Occurence of nitrates in pomes and stone fruits].
AB  - Ionometric determinations indicate that nitrate accumulation does not reach very
      high levels in pears, apples, cherries and peaches. The examination of samples
      taken from various experimental plots has shown some variations in nitrate
      contents of fruits, in relation with the uptake by trees of nitrogen, magnesium
      and calcium. Other factors liable to affect the nitrate content of fruits have
      also been examined: maturation level of fruits, application of a growth
      retardant, types of cultivars. Because of their low nitrate content, the fruits
      here studied are representative of a class of products well suited to human food
      requirements.

PMID- 1030212
TI  - [Cooking in water and nitrate content of some vegetables. Simultaneous changes in
      other nutritive components].
AB  - The author relates 2 limited studies concerning carrots and spinachs. For
      carrots, 9 samples each divided in 4 groups showed a lower nitrates content, from
      a mean value of 229 mg/kg to 29 mg/kg. The cooking water contained only 40 p. 100
      of the nitrates of the fresh vegetable. For spinachs, vitamin C and nitrates have
      approximatively the same sensibility to boiling, while magnesium diminishes
      slower, and iron seems very resistant to water extraction. The findings need
      complementary studies but suggest that as it was frequently proposed, boiling is
      a good way to eliminate contaminants, rather less aggressive against nutritional
      factors than one could dread.

PMID- 1030213
TI  - [Nitrates in canned spinach. Effects of technological treatments].
AB  - During the last twenty years, the nitrate content of spinach has regularly
      increased along with the use of nitragenous fertilizers. A study made in the
      center of Britain (France) shows that along with this growing nitrate content,
      the quantity of raw harvested spinach has practically doubled in twenty years.
      But for the same quantity of raw harvested spinach, the yield of canned spinach
      has noticeably lowered. In a cannery trials made to lower the nitrate levels
      (preheating, blanching, renewing water blanching) led to a loss of about 45% of
      nitrate (on a dry matter basis). However nitrate levels stay about the same in
      one kg of raw spinach and in one kg of processed spinach coming from the same
      batch. The only answer seems to be able and come from better agricultural
      practices.

PMID- 1030214
TI  - [Effect of nitrate content in the preparation of canned puree of spinach,
      complications which can result, precautions to avoid them].
AB  - The author reports studies made by the laboratories of the Institut Appert on the
      occasion of failures in the canning of chopped spinach caused by the presence of
      a large amount of nitrate. On the basis of technical and practical data, he
      indicates the precautions that must be taken to avoid the reocurrence of such
      failures.

PMID- 1030215
TI  - [How to reduce the nitrate content in baby foods].
AB  - Nitrates content in baby food must not exceed 50 mg/kg according to the new
      french legislation. The amount found in fresh vegetable are often higher.
      Technological methods to reduce this amount eliminate also vitamins, minerals and
      carbohydrates. For this reason, we are looking for agronomics methods to get
      lower quantities of nitrates.

PMID- 1030216
TI  - [Use of nitrates and nitrites for the processing of meat products: technological
      and microbiological aspects].

PMID- 1030217
TI  - [Nitrates and nitrites as food additives. Regulatory aspects in France and
      foreign countries].

PMID- 1030218
TI  - [Residual nitrite and nitrate content in French cooked hams and shoulders].
AB  - The test laboratory of the "Centre technique de la salaison, de la charcuterie et
      des conserves de viandes" has evaluated the nitrite and nitrate salts contents of
      1 468 cooked hams and shoulders. 90,5 p. 100 of sample have a sodium nitrite
      content of less than 150 mg/kg. 81,5 p. 100 have a potassium nitrate content of
      less than 500 mg/kg. The measured contents show a wide scattering. The nitrite
      mean content is of 61 mg/kg with a standard deviation of 95. The nitrate mean
      content is of 292 mg/kg with a standard deviation of 382. There were no
      significant variations between the various categories of cooked hams and
      shoulders.

PMID- 1030219
TI  - [Nitrates and nitrites in some commercial delicatessen products].
AB  - After a study published in 1974 on nitrate and nitrite contents of 105 cooked ham
      samples, we undertook in 1975 and 1976 another investigation of 166 samples of
      various meat products. The results are better than those of 1974: the permissible
      nitrate and nitrite levels of hams are more respected. But in some other meat
      products (sausage meat for instance) the levels are sometimes very high. Taking
      into account the quantity of meat products which can be normally consumed daily,
      nitrate and nitrite amounts absorbed only by this way are very near, if not
      exceeding, the daily acceptable intake recommended by the International Committee
      on Food Additives of the World Health Organization. It seems necessary to
      reexamine the safety margin left in some cases, to the consumer.

PMID- 1030220
TI  - [Binding of nitrite to muscle proteins].
AB  - The toxicity of nitrite and especially of nitrosamines lay down an important
      problem. The assessment of dangers for the man depends for a great part of the
      knowledge of the form of nitrite in the diet. The estimate of the part of "free
      nitrite" and "bound nitrite" in the cured meat products is a first access of this
      problem.

PMID- 1030221
TI  - [Structure of nitroso pigments in meats].
AB  - The study is concerned with the nitrosopigments formed during curing time. It
      concludes that a reductant nitrosohaem is formed, with a breakdown of the bond
      between haem and histidine, and it gives the accurate sequence of the reactions.
      This study has been conducted by measurement of the iron-dried material ratio,
      electrophoresis on acetonic extracts of pigments formed with ascorbate or
      cystein, measurement, during the photodecomposition of this extract, of
      photometric spectra, of ionised iron, and characterization of pyrroles functions.

PMID- 1030222
TI  - [State of nitrite in meat products].
AB  - The authors search the form under which nitrite is in cured products. Nitrate
      formation found by official methods is not confirmed by qualitative
      characterization. The calculations, according to the chemical equations, show the
      total breakdown of nitrite in nitroge oxide: NO, bound by many substances which
      are in meats. The distillation experiments confirm the calculations, the
      characteristic photometric spectra get in sulfitic medium and the modified
      Zambelli's reaction. These results lead to estimate that both technologic and
      toxicologic actions impute to nitrite is dominated by the idea of NO more or less
      bound, according to the medium composition.

PMID- 1030223
TI  - [Formation of nitrites from nitrates in the digestive tract].
AB  - The authors performed in vitro incubations of gastrointestinal mucosae and
      contents in the rat, under anaerobiosis, in the presence of nitrates. Nitrate
      disappearance and nitrite appearance amounts were measured in the different
      incubation media. From these works it follows that a certain quantity of nitrates
      are actually reduced to nitrites specifically by the ileo-caecal microflora of
      rats and perhaps, to a lower degree, by the action of a nitrate-reductase which
      may occur in the digestive mucosae. Moreover, the authors carried out in situ
      perfusions into the small intestine of rats, by adding nitrates to the perfusion
      liquid at a concentration of 400 mg per litre. It was thus demonstrated that the
      nitrate-absorbing kinetics is very rapid but those nitrates do not gather in the
      blood; besides, the presence of nitrites in the perfusion medium indicates a
      possible nitrate reduction in the intestinal gut.

PMID- 1030224
TI  - [Methemoglobinemias caused by ingestion of nitrites and nitrates].
AB  - Nitrites and nitrates are often responsible for methemoglobinemy. Infants, on
      account of their greater sensibility to oxidizing agents, are particularly liable
      to poison by nitrates and nitrites. Sodium nitrite can be responsible for
      poisoning after accidental ingestion or owing to an overdose when preparing salt
      provisions, or because it has been mistaken for another product. Then it is often
      a case of collective poisoning. Nitrates generally produce methenoglobinemy when
      they are changed into nitrites under the influence of a bacterial proliferation
      or of a reductase held in plants. It happens with spinach and carrot soup.
      Nitrates can pollute municipal water supply and chiefly well water. As regards
      therapy, cases of methemoglobinemy have been noted after an overdose of potassium
      nitrate and especially of bismuth subnitrate. The treatment of methemoglobinemy
      caused by nitrates and nitrites is not specific: suppression of the oxidizing
      agents, oxygenation, prescription of reducing agents.

PMID- 1030225
TI  - [Various toxic effects of nitrates and nitrites].
AB  - The main features of the long-term toxicity of nitrates and/or nitrites in man
      and experimental animals are reviewed; the possible formation of carcinogenic
      nitrosamines is dealt with in another paper of this series. It appears that the
      allowable daily intake of nitrates and nitrites for the healthy adult man has
      been evaluated chiefly from the no-effect levels in rats. First, the no-effect
      levels in rats are questionable, since some experiments have pointed out adverse
      effects of nitrates and nitrites with dosages near, or lower than, the so-called
      no-effect levels. Second, there is a risk that the allowable daily intake is
      outpassed in the diet of a man. Third, nutritional conditions, such as the
      vitamin A or C, or the iodine content of the diet, as well as other factors which
      are discussed, might alter theno-effect levels. From the cell metabolism
      viewpoint, nitrites are inhibitors of oxidative phosphorylation and of microsomal
      enzymes. Our present lack of knowledge does not yet allow us to explain the long
      term toxicity of nitrates and nitrites in terms of cell metabolic disturbances.

PMID- 1030226
TI  - [Carcinogenicity of N-nitroso compounds].
AB  - The toxic, carcinogenic and mutagenic effects of N-nitroso compounds are briefly
      discussed with reference to recent reviews. These adverse biological effects are
      discussed in relation to the necessity of metabolic activation by microsomal
      enzymes for the nitrosamins but not for the nitrosamides.

PMID- 1030227
TI  - [Health education and paramedical personnel].

PMID- 1030228
TI  - [Annual meeting of the Societe francaise d'Hygiene, de Medecine sociale et de
      Genie sanitaire. Paris, 21-22 October 1976].

PMID- 1030229
TI  - [Suicide in the province of Antwerp. Analysis of some data for the periods 1961
      1964 and 1973-1975].

PMID- 1030230
TI  - [Suicide and suicide prevention].

PMID- 1030231
TI  - [Blood filling of palatine tonsils under the action of epsilonaminocaproic acid].

PMID- 1030232
TI  - Molecular events in chemical carcinogenesis.

PMID- 1030233
TI  - Spotlight on the staff. Emergency room.

PMID- 1030234
TI  - Physician recruitment: a diagnosis and prescription.

PMID- 1030235
TI  - Computerized information retrieval for drug records.

PMID- 1030236
TI  - Clinical telemetry of EMG and temporal information during gait.
AB  - Multichannel telemetry has formed an integral part of the clinical assessment of
      children's walking problems. EMG signals and temporal information from foot
      switches are transmitted from a small belt-pack unit which provides almost
      complete freedom of movement for the child. Although patients with various
      crippling diseases have been studied, the investigation of problems resulting
      from cerebral palsy has been most valuable clinically. The effects of orthopaedic
      surgery to release or transfer muscles can be asssessed more positively and the
      causes of some unexplained gait patterns can be investigated more thoroughly.

PMID- 1030237
TI  - [Vascularization and innervation of the parietal peritoneum].

PMID- 1030238
TI  - [Usual arrangement and nomenclature of the coronary arteries].
AB  - The usual distribution of the coronary arteries of the heart as its appears from
      the study of 60 casts of these vessels is the following:--the right coronary
      artery gives three right atrial branches, the superior (sinus node artery) medium
      and inferior branches and three kinds of right ventricular branches : anterior,
      marginal and inferior. It divides into the posterior descending branch and the
      posterior left ventricular branch. Its territory is postero-septal.--the left
      coronary artery divides into 2 branches. The anterior descending artery gives
      right ventricular, left ventricular (diagonal) and septal branches for the antero
      septal territory. The left circumflex gives three left atrial branches, the
      superior, medium and inferior branches and 1 or 2 left ventricular (lateral)
      branches for the corresponding lateral territory of the left ventricule.

PMID- 1030239
TI  - [Does the phrenico-gastric ligament exist?].
AB  - On thirty cadaveric dissections, we studied the so-called "phreno-gastric"
      ligament. In fact, it appears that there is an adhesion between the fundus and
      the posterior wall in only 60 % of the cases. This adhesion is always very loose,
      easily cleaved and in no case is there a real fibrous suspensory ligament.
      Moreover, in 40 % of the cases, the posterior surface of the fundus is entirely
      covered by peritoneum and is free in the bursa omentalis. In that case, the
      posterior surface of the stomach is connected with the diaphragm by a very short
      meso extending on the right to the meso esophagus and on the left to the
      gastrosplenic ligament.

PMID- 1030240
TI  - [Anomalies of course and division of the coronary arteries and their branches].

PMID- 1030241
TI  - [Histologic changes of the thymus in guinea pigs subjected to hyperbaric
      oxygenation].

PMID- 1030242
TI  - [Anastomoses of the terminal branches of the facial nerve and of the trigeminal
      nerve].
AB  - Study of peripheric anastomoses between facial et trijeminal nerves based on 18
      dissections of 13 adults and 5 foetuses. Macroscopic study shows that those
      anastomoses are similar in all cases on any comparable levels of the face. Semi
      macroscopic study on foetuses (coloration by means of gold chlorid) and
      histological study on anastomoses (by means of longitudinal sections) reveal that
      either motor and sensitive fibres grow together and join the appropriate muscles,
      or proprioceptor fibres follow the facial nerve in the opposite direction and
      then leave it, forming recurrent branches. Cutaneous endings of muscles present a
      great number of Pacinian corpuscules.

PMID- 1030243
TI  - [Autonomic corticofugal fibers].
AB  - Lesions affecting the neocortex have been carried out in 16 cats. Wallerian
      degeneration projects to the vegetative effector nuclei (nucleus of the vagus
      nerve and the nuclei intermedio-lateralis and intermedio-medialis of the spinal
      cord). The methods of silver impregnation used were those of Nauta, Fink-Heimer
      and Velayos-Ullan. Corticofugal fibers which show an intercalary formation, such
      as the nuclei reticularis parvocellularis, lateralis and dorsalis, and the
      nucleus of the solitary tract, are more numerous. There are also direct fibers
      for the intermediate zone (intermedio-lateralis and intermedio-medialis nuclei)
      of the thoracic and sacral spinal cord.

PMID- 1030244
TI  - [Functional consequences of crossing of articular ligaments].
AB  - The movements occurring at joints with fully congruent articular surfaces, such
      as ball-and-socket joints and hinge joints, can be roughly infered from the
      geometrical forms of their articular surfaces. In these cases pure sliding occurs
      between the moving surfaces. But this is no longer true for incongruent joints,
      and in such joints the ligaments play an important role in determining the
      frequently complex nature of the movements these joints produce : with
      combinations of sliding and rolling between their moving surfaces. Finally, the
      instantaneous velocity of these moving surfaces is also strongly influenced by
      the arrangement of the ligaments.

PMID- 1030245
TI  - [The cubito-carpal region in gibbons].
AB  - As a continuation of our studies concerning the structure and fetal development
      of the human carpal articular disc (KAUER, 1968, 1975, 1976) we have investigated
      the disc-homologue in the Gibbon. For this purpose we have used the serial
      sectioned hand of a late-fetal specimen. The stratigraphical position of the os
      Daubentonii has been established comparing the situation in the Gibbon with that
      of the human ulno-carpal region. The homology presumed by others of the os
      Daubentonii with the cartilaginous primordium frequently found in the developing
      carpal articular disc in man, was found questionable. We have tried to give the
      os Daubentonii a functional interpretation as a sesamoid bone supporting the
      mechanical loaded pronation and supination of the hand in the Gibbon.

PMID- 1030246
TI  - [Anatomy of the veins of the leg].

PMID- 1030247
TI  - [Anatomic variation of the aortic coronary openings (apropos of 80 dissections)].
AB  - A series of 80 heart dissections, compared with a survey of the literature shows
      that:--both coronary ostia are usually in the right anterior and in the left
      posterior position, in the commissural plane, at the level of the corresponding
      sinus of Valsalva (the left one being often superior in size to the right one).-
      anatomic variations of the coronary ostia (especially variations of the left
      coronary ostium) may be summed up into 3 patterns: Variations in number :
      sometimes, there is only one aortic coronary ostium, usually owing to a left
      coronary artery originating from the pulmonary artery; a common aortic ostium for
      a single coronary artery is not frequent. Multiple ostia are the most common
      variations : an accessory artery may arise from a separate ostium (often the
      "third coronary artery" from the right aortic sinus; sometimes the anterior
      descending and the circumflex arteries may originate from separated orifices).
      Variations in origin remain few, affecting most often the left ostium. Variations
      in size reflect the corresponding coronary plexus preponderance.

PMID- 1030248
TI  - [Anatomic variations of the common trunk of the left coronary artery (apropos of
      80 dissections)].
AB  - An anatomic study of the main left coronary artery is reported : important
      anatomic variations may occur:--sometimes, the main left coronary artery is
      missing (1 % of the cases),--its origin may be unusual (from the pulmonary
      artery),--its average length is 11 mm; but, it may be longer (35 mm) and
      sometimes very short (less than 8 mm in 15 per cent of the cases) : this last
      aspect has to be taken in account by the surgeon during aortic valve surgery if a
      coronary perfusion has been decided.--At last, its division into two branches
      (anterior descending and left circumflex) is the most usual (65 or 70 per cent of
      the cases). A third branch of division may exist (diagonal or lateral branch) in
      about 20 to 30 per cent of the cases. The left coronary artery may also divide
      into four (or even five) branches in 5 to 10 per cent of the cases.

PMID- 1030249
TI  - [Radio-anatomic study of the bronchial arteries (apropos of 30 analyzable
      preparations].
AB  - Arteriographic studies of collateral branches of the descending thoracic aorta
      are made using barium suspension. The descending aorta is then cut off and
      measured. Confrontations of these two methods give precise details on the origins
      of bronchial arteries (vertebral level and situation around the circumference of
      the aorta). In spite of important variations, the vertebral level of origin is
      around T5 for the right bronchial arteries and around T6 for the left ones. Most
      of them (right and left) arise on the right.

PMID- 1030250
TI  - [Morphologic anatomy of the interjugochiasmatic fenestra].
AB  - The pituitary body can be surgically approached through the triangular cleft
      limited by the sphenoidal jugum and the anterior side of the optic chiasma. The
      mean surface was calculated by measurements on 51 specimens; it reached 65 mm2.
      The ratio height : width of the cleft attained 1,3-1,4 corresponding to an
      anterior chiasmatic angle of about 66-70 degrees. With regard to the variations
      of the intermalar distance, the values of the triangular surface could be
      classified into 3 types:--to a distance of 100 mm corresponds a surface less than
      50 mm2 (narrow or first grade);--to a distance of 115 mm corresponds a surface
      greater than 80 mm2 (wide or third grade);--Between these values, the surface can
      be reckoned on a grossly parabolic curve, the top of which amounts to 90 mm when
      the intermalar distance equals 107 mm.

PMID- 1030251
TI  - [45,X/ 46,XX/ 46,XY Mosaic with female phenotype].
AB  - Report on a girl with female phenotype and 45,X/46,XX/46,XY mosaicism. The
      patient showed primary amenorrhea, low stature (1,47 m), but no other typical
      features of Turner's syndrome. Chromosome studies were carried out on cultures of
      blood lymphocytes, with usual methods and with R- G- and Q-banding: 43,3 % of
      cells were 46,XY ; 36,6 % were 45,X and 20 % were 46,XX. The chromosome Y is a
      non-fluorescent one. A comparison is made with other published cases.

PMID- 1030252
TI  - [Variations of distribution of the coronary arteries (apropos of 3,000
      coronarographies)].
AB  - The various types of anomalous origin and unusual course and/or predominance of
      the coronary arteries encountered in a review of 3 000 selective coronary
      arteriograms were studied. 1. Abnormal ostia: Ectopic ostia with anterior,
      posterior or lateral displacement (11 cases). Variations in the number of ostia:-
      accessory ostium for the conus branch (68 cases);--distinct ostia for LAD and
      circumflex artery (21 cases);--single coronary artery (6 cases). 2. Abnormal
      course of coronary arteries: Anomalous circumflex origin from the right coronary
      artery (8 cases). Unusual predominance of the left coronary artery:--right
      predominance 74,5 %;--left predominance 14 %;--balanced 11,5 %. In aortic
      stenosis, the frequency of these different malformations is very different.
      Different patterns of vascularizattion of the centers of automatism and of the
      left ventricular free wall were also studied.

PMID- 1030253
TI  - [Gastro-duodenal artery arising from the superior mesenteric artery].
AB  - These exceptional anomalies of the gastro-duodenal (G.D.) arteries provide a
      better understanding of certain very odd vessels found on coeliac or superior
      mesenteric arteries selective arteriography. In our series of 400 dissected
      bodies, a typical origin of the G.D. artery from the superior mesenteric artery
      is noted in 4 cases : the aberrant vessel is identified as a G.D. artery because
      of a) its course, b) and its two usual terminal divisions : superior pancreatico
      duodenal and right gastro-epiploic arteries. On the other hand, we have 10 cases
      of G.D. artery arising from both coeliac hepatic and superior mesenteric arteries
      with:--a dominant hepatic branch in 6,--a dominant mesenteric branch in 3,--and a
      balanced origin in 1. A G.D. artery looping around the common bile duct to reach
      the anterior surface of the pancreas (Michels) was never seen in this series.

PMID- 1030254
TI  - [Lumbar epidural veins (anatomic study apropos of 31 cases)].
AB  - Using 31 corrosion preparations with fortacryl-minium, a new systematization of
      lumbar internal vertebral veins is suggested. The classical posterior
      longitudinal vein was not found. An anterior-lateral venous flow, composed of an
      anterior-internal venous canal and of an anterior-external venous canal was
      described. These venous canals jointly progress along internal face of the
      pedicle and leave a wider space between them in front of the exit foramina, to
      allow the passage of roots. The authors then study the transversal veins, the
      junction of the lumbar column with the sacral column and veins of the exit
      foramina.

PMID- 1030255
TI  - [Veins of the sacral canal (preliminary anatomic study apropos of 7 cases)].

PMID- 1030256
TI  - [Obstruction and normal rechannelization of the ureter in the human embryo.
      Relations to stenoses and congenital ureteral valves].
AB  - Study of 5 normal human embryos from 5 to 55 mm in length from vertex to coccyx,
      shows that the ureteric ducts, which in the first phases of development are
      permeable (embryos of 5-13 mm, Streeter's Horizons XIII-XVII, age from 28 +/- 1
      to 35 +/- 1 days), constantly undergo a process of obstruction and a subsequent
      recanalization of their lumen, which takes place when the embryos measure from 14
      to 22 mm. The processes begin in the middle zone of the ureters and progress
      proximally and distally until they cover its entire length. These ducts, which in
      embryos of approximately 17 mm in length form solid cords, are totally permeable
      in embryos of 23 mm. These modifications are of great importance for correct
      interpretation of the pathogenic mechanism of congenital ureteric strictures and
      valves.

PMID- 1030257
TI  - [Radio-anatomic data concerning the hyoid bone and its dynamics].
AB  - The study of the Human hyoid bone made from anatomic sections, X-ray pictures and
      radiocinema shows its variable positions during speech articulation, which vary
      according to the kind of phonema--from single horizontal or vertical translation
      to sinusoidal movements allowed by the stylohoid suspension. The hyoid bone plays
      a role in speech articulation and may have been a factor in its apparition.

PMID- 1030258
TI  - [The gastro-phrenic ligament].
AB  - The present study was carried out in order to investigate if 1) the gastrophrenic
      ligament was involved in gastric stabilization, 2) the surface of this ligament
      might be influenced by fundus distension induced by the first deglutition of the
      newborn. In a series of 23 subjects (15 adults, 8 foetuses) the surface of the
      gastrophrenic ligament was expressed in % of the postero-inferior surface of the
      stomach. The gastrophrenic ligament consisted of loose areolar tissue and its
      surface was rather small (5,89% +/- 3,8 in adults; 4,3% +/- 1,5 in the foetus).
      These facts led us to conclude that this ligament did not play a very important
      role in gastric stabilization. Furthermore the difference between adults and
      foetuses was not statistically significant; so the surface of the ligament could
      not have been changed at birth.

PMID- 1030259
TI  - Statistical study of late foetal deaths in Iraq, 1967 - 1972.

PMID- 1030260
TI  - Some epidemiological information from annual report on kala-azar in Iraq during
      1974.

PMID- 1030261
TI  - Malaria in Iraq--1974 - 1975.

PMID- 1030262
TI  - Some epidemiological and clinical aspects of kala-azar in Iraq.

PMID- 1030263
TI  - Studies on the development of the preparasitic stages of Strongyloides
      stercoralis in dog.

PMID- 1030264
TI  - Malathion poisoning among spraymen.

PMID- 1030265
TI  - Sample survey on the prevalence of toxoplasmosis.

PMID- 1030266
TI  - Some statstical data of kala-azar in Iraq.

PMID- 1030267
TI  - Urinary survey of micro-organisms and its relation to infestation with urinary
      Schistosoma haematobium.

PMID- 1030268
TI  - Intermittent short course treatment of pulmonary tuberculosis: preliminary
      report.

PMID- 1030269
TI  - A Singapore study of intermittent regimens of rifampicin plus isoniazid for
      pulmonary tuberculosis (1).

PMID- 1030270
TI  - Intermittent treatment using isoniazid and rifampicin once a week: final results
      of a controlled trial.

PMID- 1030271
TI  - Retreatment of chronic pulmonary tuberculosis with regimens including high and
      low doses of rifampicin in the intermittent phase recent and late results - a
      controlled comparison study.

PMID- 1030272
TI  - The possibility of reducing the duration of hospital treatment in patients with
      newly diagnosed minimal pulmonary tuberculosis.

PMID- 1030273
TI  - Participation of WHO in tuberculosis control.

PMID- 1030274
TI  - A slow-release preparation of isoniazid: therapeutic efficacy and adverse side
      effects.

PMID- 1030275
TI  - A slow-release preparation of isoniazid: pharmacological aspects.

PMID- 1030276
TI  - Clinical experience of acceptability of slow release matrix isoniazid.

PMID- 1030277
TI  - Two-three years follow up study of pulmonary tuberculosis treated 6 months with
      rifampicin-containing regimens.

PMID- 1030278
TI  - Supervision of out patient chemotherapy for tuberculosis with the medication
      monitor.

PMID- 1030279
TI  - Alternative models for the development of tuberculosis disease following
      infection with tubercle bacilli.

PMID- 1030280
TI  - Tuberculosis in Eskimos.

PMID- 1030281
TI  - A national tuberculin survey in Great Britain 1971-73.

PMID- 1030282
TI  - Hepatitis cases in isoniazid treated groups and in a control group.

PMID- 1030283
TI  - Isoniazid-associated hepatitis.

PMID- 1030284
TI  - Approaches to tuberculosis control in the Americas.

PMID- 1030285
TI  - Isoniazid prophylaxis and deaths in Baltimore, Maryland 1972.

PMID- 1030286
TI  - Isoniazid (INH) prophylaxis in inactive pulmonary tuberculosis: report of a
      Veterans Administration Cooperative Study.

PMID- 1030287
TI  - Tuberculosis in BCG vaccinated and unvaccinated young Swedish men. A comparative
      study.

PMID- 1030288
TI  - Post vaccination allergy after three intervals of time: preliminary report.

PMID- 1030289
TI  - A study of BCG at birth in Hong Kong.

PMID- 1030290
TI  - BCG vaccination of tuberculosis patients and of strong reactors to tuberculin.

PMID- 1030291
TI  - Side-effects of BCG vaccination.

PMID- 1030292
TI  - Further studies on chronic osteitis in infancy caused by BCG-vaccination in
      newborns.

PMID- 1030293
TI  - Treatment and long-term follow-up of patients with atypical mycobacterial
      infections.

PMID- 1030294
TI  - Epidemiology of atypical mycobacterial disease in Texas and Louisiana.

PMID- 1030295
TI  - Origin and significance of mycobacterium xenopi in clinical specimens. I. Water
      as a source of contamination.

PMID- 1030296
TI  - Response to chemotherapy of pulmonary infection due to mycobacterium kansasii.

PMID- 1030297
TI  - Applied surveillance of diagnostic and treatment measures.

PMID- 1030298
TI  - Applied surveillance of diagnostic measures Bavaria 1974.

PMID- 1030299
TI  - The history of tuberculosis in Mexico.

PMID- 1030300
TI  - The Swedish tuberculosis index.

PMID- 1030301
TI  - A British Medical Research Council Study of methods and results of treatment in
      Scotland.

PMID- 1030302
TI  - Tanzania tuberculosis survey.

PMID- 1030303
TI  - Detection and follow-up of subjects at risk of contracting tuberculosis.

PMID- 1030304
TI  - High-risk groups in tuberculosis. Incidence of newly registered tuberculosis
      during five years follow-up among a sample population of the 1968 tuberculosis
      prevalence survey.

PMID- 1030305
TI  - Characteristics of new cases of active tuberculosis.

PMID- 1030306
TI  - The control of tuberculosis in Mexico.

PMID- 1030307
TI  - Practical results of standard first-line treatment in pulmonary tuberculosis :
      influence of primary resistance.

PMID- 1030308
TI  - Integration of the tuberculosis control programme in Colombia.

PMID- 1030309
TI  - The integrated national tuberculosis programme of Sri Lanka.

PMID- 1030310
TI  - The organization of effective ambulatory treatment in a national tuberculosis
      programme.

PMID- 1030311
TI  - Comments on evaluation of results in routine practice with particular reference
      to Singapore.

PMID- 1030312
TI  - Health education and treatment in the tuberculosis control programme.

PMID- 1030313
TI  - Short-course chemotherapy in pulmonary tuberculosis.

PMID- 1030314
TI  - Short course treatment with two drugs, isoniazid plus rifampicin for six months:
      a controlled clinical trial with two treatment regimens.

PMID- 1030315
TI  - Two three-month treatment regimens for pulmonary tuberculosis.

PMID- 1030316
TI  - Simplified short-course treatment of pulmonary tuberculosis: experience with a
      regimen of ethambutol, rifampicin and isoniazid for 2 months followed by
      isoniazid or rifampicin for 4 months.

PMID- 1030317
TI  - Hong Kong tuberculosis treatment services/British Medical Research Council Study
      of 6- and 9-month regimens of daily and intermittent streptomycin, isoniazid and
      pyrazinamide for pulmonary tuberculosis.

PMID- 1030318
TI  - Controlled therapeutic trial on three second-line chemotherapy regimens (one of
      short duration) in pulmonary tuberculosis.

PMID- 1030319
TI  - Neurologic complications of gas myelography by the lumbar route.
AB  - Gas myelography is not a new technique, but its acceptance in neuroradiologic
      diagnosis has been relatively recent. Previously reported series have emphasized
      the benign nature of this technique and the lack of significant accompanying
      complications. From a series of 174 gas myelograms performed during a four-year
      period, two reports are presented wherein transient exacerbation of neurologic
      deficit followed exchange of cerebrospinal fluid and gas under pressure by the
      lumbar route. One patient with cervical spondylotic myelopathy experienced an
      increase in paresis, while another was found to have marked fasciculations.
      Speculation regarding possible mechanisms involved with these complications is
      presented. It is suggested that exchange of cerebrospinal fluid and gas under
      pressure via the lumbar route be used with caution in those patients with
      compromised cervical spinal cords.

PMID- 1030320
TI  - Cultural differences in hemisphericity: a critique.
AB  - A series of four articles on the "other side" of the brain has been published in
      this journal by Dr. Joseph Bogen and his colleagues (1, 2, 3, 4). The first three
      of these are rapidly becoming minor classics for those of us interested in
      hemispheric specialization. However, the fourth article reports a combination of
      sociologic and neurologic observations which, in our opinion, are misinterpreted.
      This misinterpretation stems primarily from the use of inappropriate statistical
      procedures and the misleading characteristics of a variable which is comprised of
      a ratio of two other variables (i.e. the A/P ratio). In short, we argue that the
      sociologic data presented (4) are not consistent with the constant sum model of
      hemisphericity discussed in that paper. An alternative model is discussed.

PMID- 1030321
TI  - Rejoinder to: "cultural differences in hemisphericity: a critique".

PMID- 1030322
TI  - More on the question of cultural hemisphericity.

PMID- 1030323
TI  - Discriminating social groups by performance on two lateralized tests.

PMID- 1030324
TI  - Workshop on low vision mobility. The low vision person--a marginal man.

PMID- 1030325
TI  - Workshop on low vision mobility. Summary of conference recommendations.

PMID- 1030326
TI  - Research and evaluation of audible output print reading aids for the blind. A
      final report.

PMID- 1030327
TI  - Supplemental sensory feedback for the VA/NU myoelectric hand. Background and
      preliminary designs.
AB  - Methods for realizing three SSF systems for the VA/NU myoelectric hand have been
      shown. In some cases, estimates concerning amputer acceptance, and references
      relating to improvements in function, were made. These estimates are purely
      speculative, and are not intended as a substitute for accurate information which
      can only be obtained by complete laboratory evaluations of the SSF system codes
      and by placing the systems on subjects. At this time, it appears that all three
      of the systems are technically feasible, and that they could be made clinically
      practical through careful design.

PMID- 1030328
TI  - Workshop on low vision mobility. Visual training with optical aids: one facet of
      low vision service.

PMID- 1030329
TI  - Workshop on low vision mobility. Evaluation of distance vision with optical aids.

PMID- 1030330
TI  - [Apparent cardiac malformations in old age].
AB  - In patients aged 79, 80 and 81 cardiac malformations were found at autopsy which
      did not permit to decide with certainty whether they were congenital or acquired.
      In the first case the lesions appeared as a band-shaped fibromuscular subvalvular
      aortic stenosis, the second one being an isolated aneurysm of the membranous
      septum directed to the righ side and combined with a minute diverticulum in the
      muscular part of the interventricular septum. The apex of the aneurysm faced the
      septal cusp of the tricuspid valve. From its dorsocranial circumference two
      tunnel-like formations projected in the dorsocranial direction terminating
      blindly beneath the atrial septal endocardium. The ventral canal protruded into
      the right, the dorsal one into the left atrium. Rather marked regressive changes
      and areas of florid chronic inflammation were found in the terminal parts of
      these channels. In the third case observed the pathological lesion were aneurysms
      of the Valsalva sinuses.

PMID- 1030331
TI  - [The course of healing of cutaneous wounds in young and old rats].
AB  - Healing of cutaneous wounds produced on the backs of young and old rats has been
      compared at ten various intervals between days 3 and 28. The only differences
      disclosed pertained to the exsudative and proliferative phases between days 3 and
      5, which were found to develop more rapidly in young rats. The phase of the
      (predominantly afibrillar) connection of the wound stumps was reduced to less
      than 5 days. The exact nature of the "sticking" intercellular substance has not
      been clarified; most probably the substance represents nonfibrillar collagen. In
      the group of old rats neoformation of fibrillary neocollagen was somewhat more
      marked during days 7 to 9 than in yound rats, in whom a rather pronounced
      exsudative component was found during that period. No significant differences
      between the two groups were disclosed during the later stages of the experiment.
      Fibroblasts participated in collagen phagocytosis during the definitive
      reconstruction of the provisional, imperfectly oriented fibrillar connection of
      the wound edges.

PMID- 1030332
TI  - [Familial malignant melanoma].
AB  - Two families with a familiar occurrence of malignant melanoma have been
      described. In the first family malignant melanoma has been histologically
      verified in two generations. In the other family, malignant melanoma occurred in
      four generations, but it has been verified histologically in two of them only. In
      the remaining two generations there were positive anamnestic data.

PMID- 1030333
TI  - [The ultrastructure of bovine lymphocytes in chronic lymphocytic leucosis].
AB  - The morphology of blood lymphocytes as obtained from cows suffering from chronic
      lymphocytic leucosis (CLL) and from healthy control animals was studied with the
      electron microscope. In the leukemic lymphocytes there was a significantly higher
      occurrence of the so-called nuclear pockets (13.8 per cent in the healthy ones).
      Marking the surface of the lymphocytes with Rutherium Red permitted to discern
      between two distinct populations of lymphocytes in peripheral blood. By using
      this method, B-lymphocyte were shown to prevail in CLL, accounting for 89.7 per
      cent of the total lymphocyte count.

PMID- 1030334
TI  - [Mesothelial polyp of the epicardium].
AB  - In an autopsied male aged 31 who had been suffering from chronic bronchitis, a
      polyp anchored at the site of the crossing of the aorta with the pulmonary artery
      was found in the pericardial sac. Histologically, the polyp was classed as benign
      mesothelioma.

PMID- 1030336
TI  - NSF probes peer review; NIH investigates awards.

PMID- 1030335
TI  - [Mesenchymal neoplasms of the skin. (A normative study)].
AB  - On the basis of a retrospective study of a large bioptic material, a scheme for a
      histological classification of mesenchymal cutaneous neoplasms has been
      suggested. The scheme as proposed here has been discussed and compared with the
      elaborations of WHO (1,2) and those of AFIP (3,4).

PMID- 1030337
TI  - [Treatment of a case of severe ulcer of the cornea, using Medi-Flow].

PMID- 1030338
TI  - [Tumor of the iris of long development].

PMID- 1030339
TI  - [Retinitis pigmentosa and familial myopia].

PMID- 1030340
TI  - [Atrophy of the pigmented epithelium with a mucular lesion without functional
      repercussions].

PMID- 1030341
TI  - [Giant bulla after trabeculectomy].

PMID- 1030342
TI  - [Results and complications of combined trabeculectomy-cataract operation].

PMID- 1030343
TI  - [Comparative study of the combined phakoexeresis-iridencleisis and phakoexeresis
      trabeculectomy operations].

PMID- 1030344
TI  - [Results of simple trabeculectomy and that combined with extraction of the
      crystalline lens in glaucoma in the adult].

PMID- 1030345
TI  - [Discussion of the report: "Microsurgery of glausoma"].

PMID- 1030346
TI  - [Difficulty of diagnosis of amputation of the temporal field in patients with
      monocular vision].

PMID- 1030347
TI  - [What should be one's attitude toward trans-sinus latero-orbital decompressive
      surgery in optic nerve injuries?].

PMID- 1030348
TI  - [Optico-diencephalic gliomas].

PMID- 1030349
TI  - [Symptomatology of disorders of the intracranial optic nerve].

PMID- 1030350
TI  - [Uveo-papillitis during disseminated lupus erythematosus].

PMID- 1030351
TI  - [Sensitivo-sensorial neuritis during anti-tubercular treatment].

PMID- 1030352
TI  - [Treatment of severe optic neuritis caused by ethambutol].

PMID- 1030353
TI  - [Intraocular pressure changes in the treatment of retinal detachment].

PMID- 1030354
TI  - [Spontaneous fluid resorption in pre- and peroperative indentation maneuvers in
      certain retinal detachments].

PMID- 1030355
TI  - [Intravitreous injection during surgical treatment of retinal detachment].

PMID- 1030356
TI  - [Ocular surgery in oligophrenic patients].

PMID- 1030357
TI  - [8 years of Binkhorst's pseudophakia in France].

PMID- 1030358
TI  - [Therapeutic effect of the forced duction test].

PMID- 1030359
TI  - [Meningitis caused by orbital injuries].

PMID- 1030360
TI  - [Obliteration of the central artery of the retina in craniofacial disjunction].

PMID- 1030361
TI  - [Thrombosis of the central retinal artery during general anesthesia under
      controlled hypotension].

PMID- 1030362
TI  - [Direct blow to the eye in tennis].

PMID- 1030363
TI  - [Macular fixation or divider fixation?].

PMID- 1030364
TI  - [Aarskog's genito-digito-facial syndrome].

PMID- 1030365
TI  - [Congenital anterior megalophthalmos].

PMID- 1030366
TI  - [Macular edema in pars planitis: angiographic aspects (apropos of a case of
      Besnier-Boeck-Schaumann disease)].

PMID- 1030367
TI  - [Ocular hypertension revealing sarcoidosis].

PMID- 1030368
TI  - [Orbital ganglioneuroma cured with cobalt therapy].

PMID- 1030369
TI  - [The Tolosa-Hunt syndrome (apropos of 2 cases)].

PMID- 1030370
TI  - Cytological study of the blood corpuscles of Lineus lacteus (Rhynchocoela,
      Lineidae).

PMID- 1030371
TI  - Ultrastructural characterization of the interphase nucleus of Gonyostomum semen.
AB  - The interphase nucleus of the chloromonadophycean alga, Gonyostomum semen
      (Ehrenberg) Diesing, has a highly distinctive appearance. Interphase chromatin is
      readily distinguishable in both light and electron microscope preparations. It
      extends throughout the neucleus and frequently makes contact with the nucleoli
      and with the nuclear envelope. Among the chromatin filaments are large numbers of
      35-46 nm diameter granules which occur singly or in clusters. The nucleoli are
      characteristically located in the posterior half of the nucleus and are composed
      of granular and non-granular components. Nuclear pores occur in slight
      depressions of the nuclear surface; their lumen has a diameter of approximately
      75 nm and contains electron-dense material. The chromatin and the large numbers
      of nuclear granules are unusual and warrant further investigation.

PMID- 1030372
TI  - On formation of melanosomes in a cultured melanoma line.
AB  - Melanosomes are present in abundant numbers in HPM-73 melanoma cells maintained
      in surum-containing cultures. However, withholding of serum for 3 days caused
      severe retardation of development of these organelles. Addition of chondroitin-4
      sulphate (0.4 mg/ml) to serum-containing culture media for 3 days resulted in
      greater numbers of premelanosomes and melanosomes relative to mitochondria. The
      same amount of chrondroitin-4-sulphate (0.4 mg/ml) added to serum-free cultures
      also resulted in an increased ratio of premelanosomes and melanosomes to
      mitochondria but, within the 3-day period many of these organelles did not attain
      the pattern of maturity evident in melanoma cells reared in serum-supplemented
      media. By exploitation of slowed rates of development of melanosomes in cultures
      (especially, but not exclusively, in serum-free samples) it was possible to
      examine various early developmental forms of these organelles. It was found that
      in this cell line mitochondria appear to be involved in the process of melanosome
      formation.

PMID- 1030373
TI  - Accreditation revisited.

PMID- 1030375
TI  - "Drug therapy and the elderly patient".

PMID- 1030374
TI  - Adverse Drug Reaction Monitoring Program.

PMID- 1030377
TI  - Self-concept and the management of people.

PMID- 1030378
TI  - Statement of functions of pharmacists and non-professional personnel in hospital
      pharmacy. Approved by the Canadian Society of Hospital Pharmacists May, 1976.

PMID- 1030379
TI  - What you see is what you get.

PMID- 1030380
TI  - Unit dose--how one hospital pharmacist became a disciple.

PMID- 1030381
TI  - Working Party on Standards for Institutional Pharmacy Service.

PMID- 1030383
TI  - How to be more effective on a committee.

PMID- 1030384
TI  - The President's viewpoint: monitoring drug therapy.

PMID- 1030385
TI  - [Reflux-behavior in the gastroesophageal transition zone following classical and
      form and function oriented gastric surgery].

PMID- 1030386
TI  - [Protein metabolism after stomach resection].

PMID- 1030387
TI  - [Changes of excretory pancreatic function in patients with liver cirrhosis and
      chronic hepatitis].

PMID- 1030388
TI  - [Excretory pancreatic function in liver cirrhosis and chronic hepatitis].

PMID- 1030389
TI  - [Colonic diverticulosis].

PMID- 1030390
TI  - [Interactions between spleen and liver].

PMID- 1030391
TI  - Carcinogenesis: a late effect of irreversible toxic damage during development.
AB  - Intrauterine and early postnatal life are periods of exceptionally high
      susceptibility to certain kinds of chemical carcinogens. The most potent known
      transplacental carcinogens are direct acting alkylating agents. Most nonreactive
      compounds, which require enzymes for metabolic conversion into chemically
      reactive "proximate carcinogens," are less effective because the required enzymes
      are present at low levels in the fetus, and many proximate carcinogens are too
      reactive to reach the fetus when formed in maternal tissues. Despite this, many
      carcinogens which require metabolic activation are very active transplancentally,
      as the intrinsic susceptibility of rapidly dividing fetal cells compensates
      effectively for comparatively low tissue levels of reactive metabolites.
      Transplacental carcinogens of all kinds are most effective late in gestation,
      generally after organogenesis has begun and after the period of greatest
      susceptibility to teratogens. Only a small number of known carcinogens have been
      tested for transplacental carcinogenic activity. The great majority of tumors
      induced transplacentally in the well-studied rodent and lagomorph species (mouse,
      rat, Syrian hamster, and rabbit) have morphologic features of adult, rather than
      embryonal, tissues. A given agent tends to induce in a given species largely the
      same types of tumor when given transplacentally as when administered directly to
      postweaning animals, unless its carcinogenic effect in the latter is ascribable
      to some peculiarity of distribution, metabolism, or physiology. In a second
      species, the spectrum of tumors induced either before of after birth may be quite
      different. For bioassay of suspected carcinogens, the significance of perinatal
      carcinogenesis lies in the facts that the fetal and preweaning rodent is an
      extremely sensitive indicator of carcinogenic activity, and that the facile
      adaptibility of fetal cells to tissue culture and their rapid expression in vitro
      of properties of neoplastic transformation make possible a rapid in vivo/in vitro
      screening system for chemical carcinogens.

PMID- 1030392
TI  - Molecular biology and biochemistry of differentiation.
AB  - Recent work in the field of molecular biology and differentiation has been
      directed towards an assessment of the number of different genes involved in the
      development and differentiation process. By the techniques of RNA-DNA
      hybridization to single copy DNA, it appears that some 60,000-200,000 different
      RNA sequences are expressed during embryonic development in the mouse. The
      differentiating brain shows the highest degree RNA transcription diversity. The
      new technique of cDNA-poly(A)-containing RNA hybridization is described. The
      nuclear poly(A)-containing RNA appears to reflect the high complexity of
      sequences as determined in RNA-DNA experiments described above. The cytoplasmic
      poly(A)-containing RNA or messenger RNA appears to represent a subset of
      approximately 10-20% of the information in the nuclear poly (A)-RNA. Also, the
      major portion of frequency class of messenger RNA in different organs such as
      kidney, spleen, and liver are common to these different organs. However, brain,
      although containing many of the cytoplasmic messenger RNA sequences found in
      liver, kidney, and spleen, has a large class of messenger RNA sequences which are
      specific to the nervous system.

PMID- 1030393
TI  - Behavioral teratology: overview.

PMID- 1030394
TI  - Techniques for assessment of teratologic effects: embryo culture.
AB  - A simple method is described for growing rat embryos in vitro for 48 hr from head
      fold to early limb-bud stages at rates of development and protein synthesis
      indistinguishable from those in vivo. Culture of the embryos can be continued for
      longer periods but at a reduced growth rate. Preheating the culture serum to 56
      degrees C for 30 min improves embryonic development, but raising the culture
      temperature 2-3 degrees C or exposing the presomite embryos to 20% O2 (160 mm Hg)
      causes malformations, particularly of the brain and spinal cord. The value of
      such culture methods for teratology is briefly discussed.

PMID- 1030395
TI  - Techniques for assessment of teratogenic effects: developmental enzyme patterns.
AB  - Most studies designed for assessing teratogenic effects focus on only three of
      four types of final manifestations of abnormal development; namely intrauterine
      death, malformations, and growth retardation. Developmental toxicity evaluations
      generally do not include functional deficits. Current techniques are inadequate
      for assessing functional capability during perinatal development, and there is a
      need for improved measures. Thus, measurement of developmental enzyme patterns is
      proposed as an approach that directly evaluates acquisition of metabolic
      competence of fundamental organ systems. During ontogenesis most organs acquire
      their full complement of enzyme activities in a programmed sequence which
      corresponds to attainment of complete functional capability. The usual
      alterations in enzyme activity that characterize these patterns occur at one of
      three time periods, namely, late fetal, early neonatal, or late suckling.
      Qualitative or quantitative changes in these patterns at any time by one or more
      key enzymes of a tissue could be indicative of developmental toxicity. Factors
      are outlined relating to consideration of developmental enzyme profiles as
      indices of maturation capable of reflecting the action of toxic agents. This
      presentation: (1) reviews the current state of the art for evaluating effects on
      development, (2) considers the applicability of enzyme patterns for biochemical
      assessment of development, (3) characterizes the target tissues and those
      metabolic pathways and/or specific enzymes most sensitive and adaptable to
      practical toxicity evaluations, and (4) describes the steps being taken to
      validate this system. The ultimate objective of this approach is to determine
      whether alterations in developmental enzyme profiles will provide a technique
      with improved capability for assessing developmental toxicity.

PMID- 1030396
TI  - Techniques for assessing teratogenic effects: epidemiology.
AB  - Epidemiologic studies of malformations can aid in the understanding of human
      teratogenesis. Employing a variety of approaches epidemiology can develop or test
      hypotheses concerning possible causes or through surveillance provide data useful
      for a variety of purposes. Drawing heavily upon our experiences at the Center for
      Disease Control, this paper reviews some concepts and uses of epidemiology in
      studies of human teratogenesis.

PMID- 1030397
TI  - Studies in adaption to ambient oxidant air pollution: effects of ozone exposure
      in Los Angeles residents vs. new arrivals.
AB  - To test the hypothesis that adaptation protecting against acute effects of
      ambient ozone (O3) exposures develops in Los Angeles residents, human volunteers
      were exposed to 0.4 ppm O3 under conditions simulating ambient pollution
      exposures. Blood biochemical, pulmonary physiological, and clinical responses
      were assessed. Los Angeles residents (N = 6) showed only minimal clinical or
      physiological response to O3, while new arrivals (N = 9) showed significant
      losses in pulmonary function and a tendency toward increased symptoms. Most
      biochemical responses did not differ significantly between residents and new
      arrivals. These results agree with others in suggesting that exposures to
      elevated ambient concentrations of O3 produce adaptation in a least some
      residents of photochemical pollution areas. The underlying mechanisms and long
      term consequences of such adaptation are unknown.

PMID- 1030398
TI  - Platinum, palladium, and lead levels in populations of Southern California.

PMID- 1030399
TI  - The use of Soluene and KOH as tissue digestants for the determination of asbestos
      in tissue.

PMID- 1030400
TI  - Developmental pharmacology: overview.

PMID- 1030401
TI  - Comparative developmental aspects of selected organ systems. II. Gastrointestinal
      and urogenital systems.
AB  - A brief description of the basic patterns of mammalian organogenesis of the
      gastrointestinal and urogenital systems is presented based on events as they
      occur in human beings. The emphasis is not on the details of this development,
      but rather on its organization and timing, with tables of comparative development
      providing a comparison of similar events in man, rat, mouse, and chick.

PMID- 1030402
TI  - Behavioral testing as a method for assessing risk.
AB  - Behavioral effects have been found to result from the prenatal administration of
      substances known to be teratogenic to the CNS. These effects occur at dose levels
      lower than those producing gross malformations and when the agent is administered
      at times other than that optimal for CNS relevant technique for detecting adverse
      consequences of prenatal exposure to drugs and chemicals. Behavioral testing,
      however, also appears to have attributes that dictate a thoughtful approach to
      its role as a method for assessing risk, and additional research is needed to
      obtain usable techniques. The need for such research is intensified by the
      present inability to identify potential behavioral teratogens by means other than
      laboratory investigation.

PMID- 1030403
TI  - Research strategies for behavioral teratology studies.
AB  - Several compelling aruguments have been advanced in support of expanding the use
      of "behavioral teratology" evaluations as routine components of toxicologic
      screening procedures. As a basis for development of effective behavioral
      teratology screening approaches, a conceptual framework is presented which
      interrelates: (1) changes in relative functional brain capacity with age, (2)
      possible times and durations of exposures to environmental insults, and (3)
      various types of toxicity testing procedures carried out at appropriate time
      points in relation to different exposure period. Within the context, several
      research strategies for behavioral teratology studies are concisely posed and
      evaluated. These include: (1) clinical hypothesis testing, where particular
      effect(s) of a given agent are evaluated based on hypotheses derived from
      clinical or epidemiological observations; (2) comprehensive screening approaches,
      where multifaceted, long-term longitudinal neurobehavioral evaluations are
      employed to assess whether any of a large number of possible deletarious effects
      are exerted by an agent and at what threshold exposure levels; (3) alternative
      screening heuristics, by which adequate assessments of neurobehavioral toxicity
      of various agents may be accomplished without completion of more exhaustive, but
      also more expensive and time-consuming comprehensive screening protocols.

PMID- 1030404
TI  - Predictiveness and limitations of test methods in teratology: overview.

PMID- 1030405
TI  - Assessment of current test procedures.
AB  - The belief that screening tests for teratogenicity are of low predictive value
      has many supporters who point to the inconsistency with which malformations are
      induced. However, to fault the test systems when such inconsistency is
      predictable from both the inherently unstable nature of a malformation and from
      fundamental principles of teratology, is unrealistic, and, as is shown, perhaps
      the greater faults lie with the critics. It is suggested by examples that, if
      attention was concentrated not on the inconsistent malformations but on more
      consistent embryopathic effects which in one form or another are always
      associated with malformations, the predictive value of the screening tests would
      appear in a more favorable light. Thus, even if malformations are not
      demonstrated, the range of conditions (dosages) in which they might occur can be
      determined. Such information, used in conjunction with that obtained from other
      preclinical studies, can then form a reasonably sound basis for extrapolation to
      man.

PMID- 1030406
TI  - The foot-and-mouth disease situation in Iran.
AB  - Foot-and-mouth disease has been known in Iran since long ago. Typing of virus was
      done in 1950 at Merieux Institute and since 1959 at Razi Institute. Type Asia 1
      was isolated three times: in 1957, in 1964 and in 1973. In June 1962, FMD type
      SAT 1 entered Middle-Eastern countries; it was soon controlled, and completely
      eradicated by the end of 1963. At the present time, endemic types of FMD cause
      limited and sporadic outbreaks in some regions of Iran; their incidence is
      lowered every year. Except the endemic types A and O, all other types in Iran are
      considered as exotic. The control measures are: 1) stamping-out policy against
      exotic types, 2) mass-vaccination of all healthy susceptible animals by a
      polyvalent vaccine, 3) regular disinfection of premises and utensils, 4) strict
      application of sanitary measures.

PMID- 1030407
TI  - [Occurence of foot-and-mouth disease in Senegal].
AB  - From December 1975 to October 1976, 13 outbreaks of foot-and-mouth disease were
      studied in Senegal. The virus, SAT2, identified at Pirbright, was in all
      probability brought from Mali or from Mauritania by transhumant animals or
      animals imported illegaly. The disease, which attacks bovines, evolved in its
      rough form without lethality. Treatment was symptomatic. Only vaccination of
      imported breeding stock and draught animals was decreed.

PMID- 1030408
TI  - An assessment of the current status of foot-and-mouth disease in Nigeria.
AB  - Foot-and-mouth disease has been widespread throughout the country in recent
      years. The disease occurs mainly in cattle though spillover of infections has
      been observed in sheep and pigs. Virus types A, SAT 2 and SAT 1 are the usual
      cause of outbreaks. The present field control method is a 6-monthly vaccination
      schedulae for animals in government ranches, the few semi-commercial ranches and
      piggeries as well as for other valuable animals and exotic animals of high
      production quality. Arrangements are under way to institute a strict and more
      comprehensive control programme against the disease in view of the envisaged
      expansion of livestock development projects and improved zoo-sanitary status
      projected for our 3rd National Livestock Development Plan. A national policy of a
      barrier and frontier vaccination programme supplemented with strategic
      vaccinations in vulnerable foci is here recommended and discussed on the basis of
      a survey on the present status of the disease.

PMID- 1030409
TI  - Freeze-drying cycles.

PMID- 1030410
TI  - Trends in freeze-drying equipment and materials.
AB  - The above discussion outlines some trends seen in the development of equipment
      for freeze-drying of various biological-like products. It has been pointed out
      that many similarities in equipment now exist. There are still areas in which a
      consensus on best design has not been reached and in these areas the user is
      offered some clear choices. Various changes have been introduced in recent years
      into freeze-drying equipment principally in an effort to increase reliability and
      improve the quality of the product produced. It is probable as more products are
      freeze-dried (and particularly as these products become more cost-sensitive) that
      manufacturers will also require that greater performance-capability be built into
      their equipment. This may perhaps translate into requirements for carrying high
      peak-vapor-rates and for automatic control in an effort to reduce drying cycles
      and increase throughput in a given machine.

PMID- 1030411
TI  - Freeze-drying equipment.
AB  - Illustrated presentation of a sophisticated research freeze-drying apparatus,
      fitted with many controls including a program controller. With this machine, it
      is possible to remove samples from any part of the chamber, at any time, without
      interfering with the freeze-drying process. By this ability to sample, the
      apparatus makes it possible to study, during the freeze-drying process, the
      influence on the dried product of many parameters and to reproduce in the chamber
      the same drying conditions offered by the production-scale machines. The figures
      include one of a production-scale machine, and a patented device for automatic
      loading and unloading of the freezers and the freeze-dryers.

PMID- 1030412
TI  - Rubber closures for freeze-dried products.
AB  - Once a biological product has been developed to perform its required medical or
      pharmaceutical function, it is essential that a container-closure system by
      chosen which will preserve the efficacy of the product up to the point of
      administration. The general requirements applicable to proper closure function
      will be reviewed and the suitability of natural and synthetic elastomers to
      perform these functions will be discussed. The specialized application of
      elastomeric materials as closures for freeze-dried products presents additional
      requirements which are superimposed upon those previously discussed. The first of
      these unique considerations relates to the proper physical design which will
      permit the outgassing of water vapor during the sublimation step in the
      lyophilizing chamber. During this outgassing the design must also permit the
      closure to remain affixed in the neck while only partially inserted. Since these
      preparations are lyophilized because they are unstable in aqueous solutions, the
      elastomer used must constitute an effective barrier to the transmission of
      moisture vapor through the closure. The MVT and gas transmission properties of
      elastomers will be discussed. Special consideration will be given to the
      extremely low temperatures used in the sublimation, stoppering, and storage
      before use of lyophilized products. The phenomenon of glass transition points
      with different elastomers will be explained as its relation to satisfactory
      performance of the closure function at low temperatures.

PMID- 1030413
TI  - Some problems in sealing gas-filled glass ampoules.
AB  - We have studied recently the ends of hand-sealed and machine-sealed, gas-filled
      ampoules of borosilicate glass. The hand-sealed ampoules were of two types: tip
      sealed and draw-sealed. The openings in the tip-sealed ampoules were estimated to
      range from 5 to 10 mu; in the machine-sealed ampoules the helix-like openings
      were less than approximately 10 mu. From the dimensions and nature of the
      openings we conclude (1) that the usual, simple methods used to test for
      "leakers" are not successful for small bore channels because pressure differences
      are less than one atmosphere and the test-time period insufficient, (2) that the
      failure of ampoules to seal may be due to the physical properties of glass and if
      this is so, ampoules containing liquid or freeze-dried preparations under gases
      cannot be sealed completely by ordinary means, and (3) that complete,
      satisfactory sealing can be done by dipping the ends of the ampoules into an
      elastomer solution which when cured provides an effective barrier even when
      stored at -70 degrees C for 12 months.

PMID- 1030414
TI  - On the adequacy of the draw-sealing of gas-filled glass ampoules.
AB  - It is recommended that a very clear distinction be made between draw-sealed and
      tip-sealed glass ampoules. We would, that is, defend the draw-seal for its proven
      value and its demonstrated freedom from microscopic channels. Where tip-sealing
      is still employed, we would suggest its reevaluation. Little more can be said in
      the absence of an immediate reason for the differences in the behavior of the
      glass in the course of the two procedures. Others may be able to explain the
      persistence of the capillary in the tip-seal in physico-chemical terms. As to
      balloon-seals, the third "variety" in common use, it would seem that their
      characteristics must derive from the way they are made. Ballooned tip-seals
      appear to have been shown by Greiff et al. (1975) to suffer the same shortcomings
      as the simple tip-seal. Where a draw-sealed ampoule is heated at the tip after
      the completion of the seal, a ballooned end would seem to have to retain the true
      seal effected in the draw process. It is perhaps sufficient to let the subject
      rest with a reassurance as to the adequacy of the common draw-seal.

PMID- 1030415
TI  - The importance of storage temperature to the quality of freeze-dried biological
      products.
AB  - Several important practical steps are recognized in the process of freeze-drying
      of biologic material. The first of these is the selection of conditions optimal
      for the stability of the substance at the normal storage temperature, usually +5
      degrees C. The second step involves the collection of material, storage at some
      choice freezing temperature (preferably around -20 degrees C) until use. The
      third step consists of the freeze-drying process itself, with preliminary
      freezing at another temperature, usually between -60 degrees and -80 degrees C.
      How these steps affect the quality of biologic products, proteins and
      polysaccharides has been the subject of study in our laboratories. The results
      have led us to the conclusion that molecular rearrangements occur at certain
      critical frozen temperatures which, in combination with time, leads to
      inactivation in some cases, stability in others. Such critical temperatures can
      be measured for other products and systems.

PMID- 1030416
TI  - Parameters to consider in the selection and purchase of a freeze-drying system.
AB  - When considering the purchase of a freeze-dryer, the user must establish his own
      performance standards and particular requirements for the following reasons: 1.
      Large monetary investment required for the purchase, operation and maintenance of
      the equipment. 2. The expense and stability of the products to be freeze-dried.
      Some of the basic parameters that must be considered: 1. Product requirements,
      such as volumes, optimum temperature, and vacuum limits. 2. Facility restraints
      relating to the availability of space, and utilities. 3. Return on the capital
      investment (ROI) 4. Technical competence of operating and maintenance personnel.
      When the parameters are established, the buyer is prepared to purchase a freeze
      dryer to best suit his needs. Precise cycle development, reliable hardware and
      personnel training, assure productivity and product quality.

PMID- 1030417
TI  - Review of United States requirements for residual moisture in drugs.
AB  - Officially recognized procedures for residual moisture determinations on
      biological products are described. These include gravimetric at ambient
      temperature and thermogravimetric analysis at specified temperatures for specific
      products. The bases for selecting the optimum residual moisture for a new product
      are discussed and values established for currently licensed products are listed.
      Comparisons are made between the procedures and requirements for biological
      products and the water determinations specificed in U.S. Pharmacopeia XIX.

PMID- 1030418
TI  - Moisture analysis of lyophilized allergenic extracts.
AB  - A simple, relatively fast, coulometric method to determine both the surface
      moisture and bound-moisture content of a wide variety of lyophilized, allergenic
      extracts has been developed. The method has been found suitable for the detection
      of residual-moisture levels in both lyophilized protein and carbohydrate samples.
      Isothermal rate-changes in moisture desorption, normalized with respect to sample
      size and plotted versus time, yield desorption curves which are characteristic of
      several individual classes of lyophilized materials. The method, when compared to
      the Official Loss on Drying Procedure for Lyophilized Biologicals, has proven to
      be faster (1.5 hr.) and more sensitive, with increased specificity and accuracy.

PMID- 1030419
TI  - Glimpses into the fundamental aspects of freeze-drying.

PMID- 1030420
TI  - Problems of contamination, exposure, and pollution in freeze-drying biological
      products.

PMID- 1030421
TI  - Numerical analysis of heat and mass transfer during freeze-drying.
AB  - The transient-state external heat and mass-transfer during freeze-drying was
      investigated. The spaces between the heaters and porous product-surfaces were
      simulated as semi porous channels, with mass-injection into the channels from the
      sublimation of ice. The energy, vorticity, concentration, and stream
      function/vorticity equations were the governing equations used as the
      mathematical model. These partial differential-equations were solved by finite
      difference, numberical methods. The Fromm, Alternating Direction Implicity, and
      Upwind Difference methods were used in solving the parabolic equations; and the
      Successive Over Relaxation method was adopted to solve the elliptic equation.
      Numerical solutions obtained from the digital computer for the external heat and
      mass-transfer during freeze-drying were computed for Reynolds numbers equal t0
      0.1, 1.0, and 4.0 and Grashof numbers equal to 0, +/- 100, and +/- 1000. The
      Prandtl number selected for water vapor was 1.0. One set of these solutions were
      compared to a known, analytical solution, and good agreement was obtained. The
      external heat and mass-transfer mechanism was then combined with the internal
      heat-transfer mechanism developed by Dyer and Sunderland (1968), and the
      equations describing the relation of heater temperatures and product surface
      temperatures developed by Massey and Sunderland (1972). A thorough computer
      simulation was carried out for the combined heat and mass-transfer mechanism
      during freeze-drying of food products.

PMID- 1030422
TI  - Freeze-drying today and tomorrow.
AB  - The freeze-drying process and equipment have been improved over the years; the
      cycle times have shortened and the dried products have improved as a result. This
      talk will deal with these improvements and how we have progressed from the early
      systems to where we are today. Such areas of discussion will include: vacuum
      pumping systems, how they are sized and designed to meet the needs for general
      and special applications; heat transfer systems, and their use in maintaining the
      drying profile; condensing surface design, and what is best for certain types of
      dryers; controls and instrumentation, and how these have played a big part in the
      drying process and have made it possible to get repeatability; refrigeration
      systems, and the part they play in the performance of freeze-drying; and lastly
      the effect of internal stoppering, bottomless trays, and other items such as
      these have had on the present state of the art. It goes without saying that there
      have been many changes and there will continue to be changes and we shall
      endeavor to look into the future--as to what might well bo some of these changes.
      Included in the talk will be a number of slides and illustrations to point out
      the various items as they are discussed.

PMID- 1030423
TI  - Sublimation of formaldehyde in freeze-drying.
AB  - Formaldehyde solution, commonly used to inactivate bacterial, rickettsial and
      viral suspensions during the preparation of vaccines, is known to have a
      deleterious effect on many antigens during freeze-drying. Sublimation of
      formaldehyde in shell-frozen and plug-frozen aqueous samples was investigated by
      measuring the residual formaldehyde periodically during the freeze-drying
      procedure. It was found that formaldehyde, even while subliming, concentrated on
      a volume basis. This was more apparent with the plug-frozen than with the shell
      frozen material. Moreover, in the preparations taken to dryness, the formaldehyde
      polymerized to form paraformaldehyde. It was found that the addition of methanol
      not only prevented polymerization, but also significantly increased the
      sublimation of formaldehyde without concentration of the latter.

PMID- 1030424
TI  - A new freeze-drying technique for processing biological materials.
AB  - Wet granulation and dry blending are standard techniques used in tablet
      formulation. Both techniques impose limitations on the ability to produce
      homogeneous tablets with rapid dissolution and controllability of the matrix for
      active ingredients. This report describes the development and application of a
      new freeze-system using a swirling bath of Freon-12 to process sensitive
      biological materials. The frozen beads produced with this process are
      subsequently freeze-dried and may be used to produce precise tablets. The ultra
      rapid freezing (7-14 milliseconds) provided by the Freon-12 process yiels
      amorphous homogeneous spheres by retarding component migration which permits
      precise control of pH and redox potential in the final product. Dissolution of
      tablets prepared by this Du Pont process is so rapid (8-12 seconds) that a
      special testing technique is required for measurement of dissolution time.
      Improved recoveries of activity have been demonstrated for sensitive biological
      materials compared to conventional freeze-drying. The optimization of droplet
      sizes is controlled by injection rate, stream diameter and surface velocity of
      the Freon-12 bath. Droplet size control permits attainment of weight precision in
      the range of 0.6 +/- 0.06% for a final 50 mg tablet. This compares with a tablet
      weight precision of 1% to 2% typical of dry blending and wet granulating.
      Potential applications of this technology include pharmaceuticals and the
      production of ultra precise reagent tablets for the Du Pont Automatic Clinical
      Analyser.

PMID- 1030425
TI  - Long term storage studies with a new stabilised formulation of yellow fever virus
      vaccine.
AB  - A new formulation of yellow fever virus vaccine incorporating a stabiliser has
      been prepared which is very much more stable than conventional unstabilised
      vaccines. This vaccine has a half life of 2-4 years at 4 degrees C, 9 months at
      20 degrees C and 10 days at 37 degrees C. Its greater stability should have
      considerable advantages, especially when it is used in tropical countries.

PMID- 1030426
TI  - Freeze-drying of a purified human diploid cell rabies vaccine.
AB  - A rabies vaccine prepared in human diploid cell strains was purified by
      continuous-flow sucrose density gradient centrifugation. The peak fractions
      containing 35-40% sucrose were diluted with a stabilizer consisting of degraded
      gelatine in a Tris-EDTA-buffer, and then inactivated with beta-propiolactone and
      freeze-dried to a residual moisture of approximately 2.5%. This vaccine was
      stable as proved by accelerated stability tests.

PMID- 1030427
TI  - Stability of live, freeze-dried virus vaccines.
AB  - Stability of live, freeze-dried vaccines is a major factor for successful
      vaccinations. Vaccines may be stored at -20 degrees C or less for long periods
      without loss of activity and this storage does not affect stability during
      subsequent storage. Storage in the refrigerator for long periods is harmless for
      certain very stable vaccines such as influenza, rubella, NDV, Marek's. Other
      vaccines, such as IBV, show a significant loss in titer after 2 years. The
      routine use of an accelerated stability test, e.g. exposure of each lot
      manufactured to 37 degrees C during 7 days, provides useful information regarding
      the stability of the vaccine at +4 degrees C. In general the loss during the
      accelerated stability test is higher than the loss after 24 months storage in the
      refrigerator. Specifications requiring that each vaccine lot must possess, after
      the accelerated test, a titer equal to or higher than the minimum titer needed
      for immunization, are a guarantee of sufficient potency at the time of
      administration. To solve the problems in tropical countries stable vaccines are
      essential. Cendevax and Rimevax exposed to tropical temperatures still possess
      the minimum required titer after several days.

PMID- 1030428
TI  - Stability characteristics of freeze-dried human live virus vaccines.
AB  - Freeze-drying (lyophilization) of biologically active materials such as human
      live virus vaccines is an accepted method of preserving potency. Since freeze
      drying does not assure total stability, a formal system of monitoring stability,
      i.e., potency, has been established. Two experimental desings are utilized: (1)
      Long term studies to duplicate normal use storage at -20 degrees C and 2-8
      degrees C and (2) Accelerated studies which predict long term stability through
      regression analysis using the Arrhenius equation. Data summarizing stability
      experience over a long period of study will be presented.

PMID- 1030429
TI  - The production and use of rinderpest cell culture vaccine.
AB  - Description of preparation, safety and efficacy testing of a rinderpest cell
      culture vaccine which is observed in lyophilized form and should be used within
      two hours following its reconstitution. Excellent results have been obtained with
      this vaccine in Kenya, Uganda and Tanzania.

PMID- 1030430
TI  - Recent departures in volume freeze-drying.

PMID- 1030431
TI  - Methods for determining favorable conditions for freeze-drying biological
      reference materials.
AB  - By predetermining favorable conditions for freeze-drying samples through pilot
      runs, one can gain more assurance that relatively large batches of lyophilized
      biological reference materials produced have the desired characteristics.
      Included in the pilot studies are the determination of the characteristics of the
      lyophilizer with a specific freeze-drying cycle, simulation of the water load
      expected for the production run, residual moisture analyses of the lyophilized
      samples, and biological activity of the samples before lyophilization and after
      exposure to elevated temperatures. Various reference materials have been
      lyophilized by these procedures. Among them are clinical chemistry reference
      samples, bacterial suspensions, and candidate serum-protein reference
      immunological standards. A batch of 6,300 vials of the latter was successfully
      freeze-dried and showed less than 0.1% residual moisture; different proteins
      (including complement) were both functionally (enzymatically) and antigenically
      active.

PMID- 1030432
TI  - Freeze-drying of spermatozoa.
AB  - Bull semen was diluted to a concentration of 2 X 10(8) cells/ml, cooled to 5
      degrees C in 5 h, frozen in 0.025 ml spheres on the surface of solid carbon
      dioxide, and stored in liquid nitrogen. 50% by volume of the diluent was 325 m0sm
      Tes:N-tris (hydroxymethyl) methyl-2-amino ethane sulfonic acid titrated to pH 7.2
      with 325 m0sm Tris:tris (hydroxymethyl) amino methane. The diluent also contained
      30% by volume isotonic sodium citrate and 20% by volume egg yolk. The frozen
      spermatozoa were freeze-dried in 400 mg quantities in test tubes at -50 degrees C
      with a condenser at -196 degrees C. Moisture content was determined by weighing
      the individual samples before and after freeze-drying. Drying the samples for
      several days at 20 degrees C removed 868 mg from each gram of frozen material and
      this was considered the zero moisture level. Samples were stored at 20 degrees C
      or -196 degrees C after freeze-drying. The freezer-dried samples were rehydrated
      by flooding with five times their original volume of isotonic sodium citrate.
      Tests of the recovered spermatozoa included percentage motile cells, acrosome
      damage, enzyme release, protein denaturation, hypotonic swelling and fertility
      testing. Sperm motility decreased with dryness until it reached zero at 3%
      moisture. Acrosome morphology and enzyme release appeared normal down to 1%
      moisture. Preliminary results showed some fertility at all levels of dryness with
      -196 degrees C storage, and fertility at less than 1% moisture with 20 degrees C
      storage. Additional fertility testing is underway.

PMID- 1030433
TI  - Freeze-drying of histocompatibility typing sera.
AB  - This report describes a unit employed for the freeze-drying of histocompatibility
      typing sera using a 50-h cycle. The unit will process approximately 3,200 3-ml
      vials with a final residual moisture content of less than 2%. The system employs
      dry ice-alcohol cooled circulating baths to maintain the condensers below -60
      degrees C, and two shelf-cooling baths to maintain the product at the required
      temperatures during the freeze-drying process. The results of a recently
      conducted 5-year study of the effect of residual moisture as a function of time
      and storage temperature are also included. Studies conducted to date indicate
      that with residual moistures below 2%, freeze-dried histocompatibility sera can
      be stored at +4 degrees C without the loss of significant tissue typing factors.
      Solubility of all serum was lost when samples were stored at +37 degrees C or
      higher during this same 5-year period. The long-term storage studies are being
      continued.

PMID- 1030434
TI  - Biological standards: problems in large-scale production.
AB  - A biological standard usually consists of a batch of perhaps several thousand
      ampoules. In defining a batch of ampoules to be a standard, we are in essence
      making a number of fundamental claims: (1) That in terms of content, (mass and
      potency) each individual ampoule is identical to every other amoule in the batch.
      (2) That in the  course of preparation of the standard, the contents of each
      ampoule have been treated in exactly the same way and held for the same length of
      time under the same conditions, (i.e. all the ampoules of the standard have been
      treated as one single batch, each stage of processing being carried out under
      constant conditions in one complete working session, however long). (3) That the
      stability or instability of the biological activity of the contents of each
      ampoule of the batch is identical to every other ampoule (i.e. that moisture,
      oxygen, light, raised temperature--all factors which cause deterioration of
      biological activity--have been exculuded to the same degree in each and every
      ampoule in the batch, so that each ampoule of the standard is equally stable or
      unstable). It is quite a difficult task to meet these criteria even in a small
      number of ampoules at the bench. It becomes a very demanding exercise to achieve
      the same results in 4,000 ampoules--the normal batch size at NIBSC. Details of
      the methods used at NIBSC for the production of large batches of ampoules of
      biological standards have already been published (Campbell, 1974). The author of
      the papers will take the opportunity to develop various aspects of the published
      detail.

PMID- 1030435
TI  - Research and development of phamaceutical dosage forms.
AB  - The development of a suitable formulation and a freeze-dry cycle for a
      pharmaceutical dosage form requires knowledge of some basic properties such as
      (1) eutectic temperature, if one exists, (2) temperature effect on solubility,
      (3) degree of supercooling, (4) heat transfer properties of the frozen product
      and (5) equipment design and equipment capability. Basic work with several
      inorganic and organic salts shows that eutectic temperature is a function of the
      melting point and the differential heat of solution of a drug. From a knowledge
      of these parameters, a mathematical expression can be used to estimate eutectic
      temperature. The desired characteristics which can be achieved by proper
      formulation of the solution to be freeze-dried and by employing optimum freeze
      drying cycles include an intact cake, sufficient strength, uniform color and
      rapid reconstitution. By utilizing resistivity measurements to determine eutectic
      temperature and supercooling properties it is possible to reformulate products,
      increase batch sizes and reduce overall times for freeze-drying cycles.

PMID- 1030436
TI  - Importance of freeze-drying of biological products.

PMID- 1030437
TI  - The physico-chemical basis for the freeze-drying process.
AB  - To the extent that the final form and quality of a freeze-dried product depends
      on the way the freeze-drying is conducted, an understanding of the many factors
      involved is most important. The numerous effects of the design and mode of
      operation of the freeze-drying equipment on the course of the process need to be
      known, as do the properties intrinsic to the material to be freeze-dried. Much
      can be learned and predicted from the study of the "supplemented phase diagram",
      a series of experimental plots describing the equilibrium and the non-equilibrium
      phase behavior of the system in question. Such diagrams map and distinguish
      eutectic and amorphous phase behavior. Further information is available from
      gravimetric studies allowing the construction of "desorption isotherms", the
      plots describing the loss of sorbed water accompanying the sublimation of ice,
      frequently termed "secondary drying". These plots relate the water retained by
      the product to the "water activity", or relative humidity at different
      temperatures. Observations in the freeze-drying microscope contribute additional
      information, in that they reveal the actual course of the process at the
      microscopic level. These and other laboratory findings facilitate the analysis
      and comparison of pilot-plant and commercical scale processing experiences. Where
      scientific and engineering factors appear to interrelate, the nature and extent
      of the interdependence can often be determined.

PMID- 1030438
TI  - Predicting stability of lyophilized products.
AB  - The usual purpose of freeze-drying is to enhance the stability and thus the
      marketability of a product. Increasing the length of a product's integrity,
      however, often requires that the formulator be able to predict the extent of that
      increased shelf life. Based on the Arrhenius principles, techniques are available
      that can allow such shelf life estimates with an acceptable degree of confidence.
      The presentation reviews examples of ongoing studies demonstrating predictive
      techniques as applied to freeze-dried products. The examples cover the most
      common situations which call for straight-forward and generally accepted
      principles of prediction; that is, measuring a specific potency loss at several
      elevated temperatures and then predicting the time for the same loss at normal
      storage. Other situations, however, as is the case with many in vitro diagnostic
      products used in clinical laboratories, require a modification of this technique.
      In those instances, monitoring of the proper "functioning" of samples of a
      product subjected to exaggerated temperature conditions with an eye to predicting
      shelf life is reviewed.

PMID- 1030440
TI  - Development of equipment for lyophilization.

PMID- 1030439
TI  - Optimization in freeze-drying.
AB  - The author assumes that success in freeze-drying must be judged in economic
      terms. Following a summary of the reasons given for adopting freeze-drying, and
      an historical outline to explain the changing emphasis in the performance
      requirements of equipment, desirable features in design and operation are
      reviewed as the basis for a charter for plant manufacturers and an aid to
      comparison between different types of plant. Ways of appraising value for money
      are examined and a novel method is proposed for maximizing throughput by
      optimising the conditions in the freeze-dryer.

PMID- 1030441
TI  - Acute alterations in stroke volume during exercise at 3,100 m altitude.
AB  - Following 3 weeks exposure to an altitude of 3,100 m, the cardiac output response
      to upright submaximal exercise was examined in 3 healthy subjects breathing
      ambient air and breathing 60% oxygen. The procedure allowed acute alteration of
      the 2 conditions within a single testing period of 30 min, 60% oxygen breathing
      either preceding or following breathing ambient air. Cardiac output was also
      measured in two of the subjects during maximal exercise under these two
      conditions. Administration of the high oxygen inspirate during exercise had
      little effect on the level of cardiac output but resulted in an immediate
      bradycardia and a dramatic increase of approximately 16% in stroke volume. Stroke
      volumes during maximal exercise were also increased by approximately 10% by the
      administration of high oxygen. It is suggested that the condition of decreases
      exercise stroke volume which develops with chronic exposure to altitude may be
      largely the result of diminished myocardial contractility stemming from a
      condition of myocardial hypoxia.

PMID- 1030442
TI  - Problems of ergonomics in Bali, Indonesia.
AB  - Development in Indonesia, particularly in Bali, has been planned and done through
      several stages of the Five-Year Development Programs, which started in 1969, and
      emphasized intensification of agriculture and extensification of industries
      related to potential resources available in the region. In the process,
      industrialization, being regarded as a prerequisite to higher living standards,
      brought with it problems concerning safety, health, and work conditions,
      especially with respect to transfer of technology. As examples, experiences and
      data, related particularly to ergonomics in the sectors of agriculture, hotel
      business, textile mills, transportation, and others in Bali, Indonesia, are
      reported. In dealing with such possible consequences of development, efforts to
      find fundamental solutions should be given the highest priority. It is necessary
      to make use of all the existing institutions having potential functions and roles
      in the policy of development planning, and to take into consideration the factors
      of safety, health, and work conditions in specifying technical and financial
      development projects for industrialization.

PMID- 1030443
TI  - Effects of industrialization on working schedules.
AB  - Recent increase in industrialization has resulted in attention being drawn to
      diversity of working schedules and their interrelation with content of work. The
      results of joint research revealed that adaptation to industrial jobs is made
      difficult because of urban conditions and modern work-control systems, such as
      workers in flexible-working-time systems who apparently favored regular daily
      working cycles. Long overtime work in smaller undertakings and the spread of
      shift systems are two important features of industrial work schedules, each being
      dominant among skilled and non-skilled jobs. Another important facet is the
      problem of intra-shift work-rest schedules significant for machine operations and
      vigilance tasks. It is suggested that phases of work that become intolerable are
      correlated with unnatural work rhythms. More emphasis should thus be laid on both
      phase-shifted work and non-self-governing work, the key factor being the
      relevance of attained data to real work in the whole course of schedules of work
      and rest.

PMID- 1030444
TI  - Ergonomics in traditional Iranian industries.
AB  - It is an acknowledged fact that Iranian carpet weavers are subject to excessive
      fatigue. Earlier investigation has shown this to be largely due to a non
      ergonomic body position while working at a traditional loom. It would appear that
      significantly increased production could be achieved by eliminating or reducing
      this fatigue. An Iranian engineer has attempted to do this by inventing a metal
      loom which takes ergonomic factors into consideration. The purpose of this study
      was to evaluate the effect of the new loom by comparing the productivity of two
      groups in Kerman, Iran: one using the new ergonomic loom and the other using the
      traditional loom. In preliminary investigations various factors were taken into
      account so that the two groups might be considered comparable. After several
      observations the average productivity of each weaver was calculated (according to
      knots per day). The results showed that the ergonomic loom had the highest
      productivity figures for both sexes and that increased productivity was directly
      related to the degree of comfort of the carpet weavers.

PMID- 1030445
TI  - Some observations on the needs of ergonomics in industries in Hong Kong.
AB  - The author's interest in ergonomics lies in the common ground it shares with
      occupational health, since ergonomics aims to make work easier, safer, and more
      productive and to promote efficiency, comfort, and health. In Hong Kong, owing to
      lack of natural resources and guaranteed markets, industrialization has not taken
      a smooth course. Only light industries exist, and one industry flourishes after
      another. Occupational health and safety tends to be neglected not only by the
      employers but by the employees. The government becomes the promoter of labor
      legislation. There is almost no information on occupational diseases. There are
      some elementary official statistics on occupational accidents. There is
      practically no research activities on this area going on. There is a very
      critical lack of occupational health, workers in Hong Kong. Ergonomics may help
      in improving the present situation because its aims are more positive to the
      industrialists and the workers who should be converted into educated consumers of
      ergonomics. In the long run, advancement in occupational health and safety
      practice will be made.

PMID- 1030446
TI  - Application of ergonomic principles in the factories of a developing country.
AB  - Several examples of the need for the application of sound ergonomic principles in
      Singapore factories are presented. Emphasis is laid on the necessity to consider
      local habits and customs in the devising of ergonomic solutions to occupational
      health problems. Examples are given concerning vehicle cabin design, difficulties
      due to climate differences in applying personal protective equipment or in
      building design, inadequate displays warning dangers, and health consequences of
      technical improvements, safety measures, or measures to achieve greater
      efficiency. Sometimes ergonomic practices may promote productivity but be
      prejudicial to health. In rapidly-changing and cosmopolitan Singapore, ergonomic
      principles are vital to all facets of manufacturing processes and the
      transportation and distribution of goods, but ergonomic practice can be
      complicated by several factors as indicated by such examples.

PMID- 1030447
TI  - Ergonomics for occupational hygienists in developing countries with examples from
      Sri Lanka.
AB  - Occupational health problems in developing countries, especially those situated
      in the tropical zone, are difficult to define. The conditions are more adverse in
      unorganized small-scale industries. The application of ergonomic principles in
      the practice of occupational health in developing countries must be subject to
      all aspects of community health and impact of industrialization as well.
      Ergonomics offers a broad concept to health scientists in developing countries.
      "Systems ergonomics" is not applicable. On the contrary, the fact that ergonomics
      conveys a different meaning to those in developing countries is highlighted by a
      few examples from Sri Lanka. The author presents his view for consideration in
      the development of international instruments to prescribe the sale of guarded
      machinery to developing countries and the limitation of incentive schemes for
      performing arduous tasks leading to occupational illnesses.

PMID- 1030448
TI  - Designed and real working situations in machine systems operation.
AB  - New work situations designed at the stage when new machine systems are introduced
      are realized on the assumption that the new systems can maintain their designed
      functions consistently, generally eliminating previous work habits and without
      sufficient knowledge about real working processes and skills. This may produce
      differences between designed and real working situations. Some examples are
      presented from observations on influence of modern design of cargo ships on their
      crews. It was difficult for crews to maintain stable working conditions,
      especially when machine systems deviated from their designed functions. Often the
      crew had to work in off-duty hours giving up private freetime activities. Among
      various factors contributing to the discrepancies between designed and real work,
      lack of availability of the new systems is the most important factor. Also
      important is lack of back-up systems which would function either when the machine
      systems are out of order or when previous working skills and habits must be
      applied. A need for developing methods of evaluation of these two factors from
      ergonomic points of view is pointed out.

PMID- 1030449
TI  - Mechanization of agricultural work in Japan from an ergonomic point of view.

PMID- 1030450
TI  - Working conditions and opinions of industrial workers in Thailand.

PMID- 1030451
TI  - An interdisciplinary approach to a trouble-shooting manual for vehicle drivers.

PMID- 1030452
TI  - Basis for scientific studies of real life human acts.

PMID- 1030453
TI  - Shoulder muscle tenderness and physical features of female industrial workers.
AB  - Physique, muscle strength, and jump-step scores of female industrial workers,
      ages 17--34, were studied in relation to tenderness of shoulder muscles for five
      groups, (A) character display operators, (B) fluorescent lamp assemblers, (C)
      photographic film rolling workers, (D) teachers and nurses of handicapped
      children, and (E) office workers. No significant differences were found between
      the five groups in mean body height, body weight, and skinfold thickness, but
      mean knee extension force of groups A and C and mean back muscle strength of
      groups A, B, and C was significantly lower than that of group E. Workers of
      groups C and D with a low tenderness threshold of m. trapezius of 0.6 kg/cm2 or
      less had stiff shoulders more frequently and lower force levels of knee
      extension, back muscle, and upper arm abduction than those without tenderness. No
      similar tendency was found for groups B and E. Further, among workers with
      objective signs of occupational cervicobrachial disorder, there were few whose
      knee extension force or jump-step scores were above the averages of normal office
      workers. Shoulder muscles of such operators were revealed to be continuously
      contracted during operations. The possible effects of chronic fatigue due to
      repetitive operations on developing localized tenderness and occupational hazards
      are discussed.

PMID- 1030454
TI  - Activity of established dominant focus and cortical arousal level.

PMID- 1030455
TI  - Location and sound spectral properties of vocalization evoked by electrical
      stimulation of rat's brain.

PMID- 1030456
TI  - Effects of asbestos and beryllium compounds on the alveolar macrophages.

PMID- 1030457
TI  - Microwave treatment for sudden deafness.

PMID- 1030458
TI  - [Basic characteristics of regulations on the minimal conditions of proper hygiene
      involving general-use objects].

PMID- 1030459
TI  - [Hygienic supervision of production, circulation and sampling of objects made out
      of plastics].

PMID- 1030460
TI  - [Hygienic supervision of production, circulation and sampling of objects and
      equipment made from ceramics and enameled plates].

PMID- 1030461
TI  - [Hygienic supervision of production, circulation and sampling of objects for
      general use made out of rubber].

PMID- 1030462
TI  - [Hygienic supervision of production and circulation of metal-wrapping materials
      and of the raw materials used in their production].

PMID- 1030463
TI  - [Proper hygiene involving tobacco and tobacco products].

PMID- 1030464
TI  - [General principles for checking the proper hygiene involving general-use objects
      (monitoring), and the importance of sample collection and dispatching for
      analysis and interpretation of results].

PMID- 1030465
TI  - [Problems in human environmental protection involving waste materials created by
      industry and by usage of various objects for general use].

PMID- 1030466
TI  - [Importance of hygienic control of preparations for personal hygiene, personal
      care and for the improvement of face and body. Hygienic supervision of production
      and circulation; organoleptic reviews; sample collection and dispatching for
      analysis and preventive measures].

PMID- 1030467
TI  - [Results of laboratory studies on heavy metals contained in preparations for
      personal hygiene, personal care and improvement of face and body, and related
      problems].

PMID- 1030468
TI  - [Proper hygiene involving preparations for personal hygiene, personal care and
      improvement of face and body from the bacteriological aspect].

PMID- 1030469
TI  - [Microbiological control of preparations for personal hygiene, personal care and
      improvement of face and body (cosmetic products)].

PMID- 1030470
TI  - [Household disinfectants].

PMID- 1030471
TI  - [Household disinfectants].

PMID- 1030472
TI  - [Hygiene preparations for the household. Detergents and other preparations;
      hygienic aspects of production, circulation and use; proper hygienic conditions
      of the preparations].

PMID- 1030473
TI  - [Definition and etiology of chronic pulmonary heart disease].

PMID- 1030474
TI  - [Pathologico-morphological changes of the lung, pulmonary vascular bed and heart
      in chronic pulmonary heart disease].

PMID- 1030475
TI  - [Clinical diagnosis and evolution of chronic pulmonary heart disease].

PMID- 1030476
TI  - [Electrocardiographic criteria and arrhythmias in chronic pulmonary heart
      disease].

PMID- 1030477
TI  - [Estimation of pulmonary-artery pressure as based on clinical findings and
      determinations of pulmonary function].

PMID- 1030478
TI  - [Hemodynamic studies on chronic pulmonary heart disease using invasive and
      noninvasive methods].

PMID- 1030479
TI  - [Pulmonary heart disease as a differential diagnostic problem in pneumology].

PMID- 1030480
TI  - [Rehabilitation principles in chronic pulmonary heart disease].

PMID- 1030481
TI  - [The concept of health care in national defense].

PMID- 1030482
TI  - [The role and tasks of internal medicine in a contemporary war].

PMID- 1030483
TI  - [Tuberculosis under war donditions and evaluation of physical fitness for service
      in the armed forces].

PMID- 1030484
TI  - [Surgical treatment of thoracic injuries in the armed forces. General
      characteristics of war injuries].

PMID- 1030485
TI  - [Disability as a result of respiratory tract disease].

PMID- 1030486
TI  - [Rational and irrational use of antibiotics].

PMID- 1030487
TI  - [Cystic fibrosis (fibrosis cystica, mucoviscidosis, mucosis, cystic fibrosis of
      the pancreas, fibrocystic pancreatic disease, pancreatic fibrosis].

PMID- 1030488
TI  - [Pulmonary function in children and adolescents with cystic fibrosis].

PMID- 1030489
TI  - [Unusual pleural calcifications among the population of Klinovo].

PMID- 1030490
TI  - [Respiratory hemosensitivity in patients with chronic obstructive diseases of the
      respiratory tract].

PMID- 1030491
TI  - Interpretive man: the enlarged self-image.

PMID- 1030492
TI  - New approaches to the analysis of personal constructs in person perception.

PMID- 1030493
TI  - Metaphors for living.

PMID- 1030494
TI  - The interaction model of communication: through experimental research towards
      existential relevance.

PMID- 1030495
TI  - Current motivational models in the elaboration of personal construct theory.

PMID- 1030496
TI  - The child's constructing of self.

PMID- 1030497
TI  - Gonadal effects of pinealectomy and immunization against N
      acetylindolealkylamines in the hamster.
AB  - In order to determine whether circulating melatonin (MEL) is necessary for the
      gonadal regression seen in hamsters exposed to a short photoperiod, animals were
      immunized with N-acetylserotonin (NAS) conjugated to protein. Antibodies formed
      against this conjugate bind MEL and NAS equally. When exposed to a short
      photoperiod (L:D, 1:23), a dramatic regression was seen in gonadal weight with no
      effect on body, Harderian gland or adrenal weight. Plasma testosterone levels
      also dropped. Immunization against NAS did not modify these effects, suggesting
      that circulating MEL does not mediate the antigonadal effect of the short
      photoperiod.

PMID- 1030498
TI  - Differential localization of pituitary-adrenal activation and temperature changes
      following intrahypothalamic microinjection of morphine in rats.
AB  - Microinjections of morphine (MOR) into the basal mid-hypothalamus of rats elevate
      corticosteroid production of adrenal glands in vitro and plasma corticosterone
      (B) levels. Injections in or close to the rostral part of the arcuate nucleus
      were most effective in producing pituitary-adrenal activation, without affecting
      body temperature. Injections of MOR in the anterior hypothalamic area caused
      hyperthermia or hypothermia, depending on the dose and the site of injection,
      with little or no effect on piutitary-adrenal activity. The results indicate that
      piutitary-adrenal activation by MOR is mediated by structures in or close to the
      rostral part of the arcuate nucleus and that these structures can be
      distinguished from structures where MOR elicits temperature changes.

PMID- 1030499
TI  - Biogenic amine control of growth hormone secretion in the fetal and neonatal rat.
AB  - The development of the hypothalamic-pituitary axis for growth hormone (GH)
      secretion has been studied in the rat fetus and in the neonate 4, 24, 48 and 72 h
      after birth. Injections of the serotonin blocker cyproheptadine (Cypro) and a
      catecholamine, dopamine (DA), each led to reductions in the level of serum GH in
      21 to 22 day fetuses and in neonates up to 3 days after birth. The O-methylated
      derivative of dopamine, dimethoxyphenylethylamine (DMPEA), did not alter serum GH
      levels from those seen in saline-treated control animals. These results indicate
      that biogenic amines exert control over GH secretion in the fetus, close to term,
      and in early neonatal period. They suggest that this control is similar to that
      seen in the adult rat and in man and that such control may operate through
      serotonin receptors.

PMID- 1030501
TI  - The pigmentary dispersion syndrome and glaucoma.

PMID- 1030500
TI  - Biochemical effects of treatment with oral contraceptive steroids on the
      dopaminergic system of the rat.
AB  - The effects of acute and chronic administration of a combination of lynestrenol
      mestrenol, a widely employed contraceptive medication, on the dopaminergic system
      of the rat forebrain and striatum were investigated to better understand the
      biochemical basis of the neurological side-effects of steroid contraceptive drugs
      (SCDs). Both acute and chronic treatment increased the disappearance rate of
      striatal dopamine (DA) after synthesis blockade with alpha-methyl-p-tyrosine
      (alpha-MpT). Moreover, the conversion of 3H-tyrosine (3H-T) into 3H-DA was
      increased in the forebrain and striatum after chronic administration of this
      steroid combination. In the same animals, the utilization of tyrosine (T) is
      increased.

PMID- 1030502
TI  - Ophthalmoplegic migraine and periodic migrainous neuralgia, migraine variants
      with ocular manifestations.
AB  - The spectrum of migraine has been outlined with particular attention to two
      entities: Ophthalmoplegic Migraine and Periodic Migrainous Neuralgia. Although
      quite different in many respects from classical migraine, the relationship of a
      periodic localized vascular phenomenon giving rise to headache and transient
      neurologic signs, classify PMN and OPGM as migraine variants. Supportive of this
      concept, the literature has been reviewed in both entities, and some observations
      are made on the validity of earlier reports. It is the author's opinion that
      Raeder's syndrome should be reserved for patients with a lesion localizing in the
      paratrigeminal area. This does not exclude migraine as an etiologic agent but
      also recognizes tumors, infections and fractures as being more common.

PMID- 1030503
TI  - Cutting the cost of medical assistance.

PMID- 1030504
TI  - Minor skirmish in a monumental struggle: HEW's analysis of mental health
      services.

PMID- 1030505
TI  - On "Cutting the cost of medical assistance".

PMID- 1030506
TI  - Anatomy of the heroin problem: an exercise in problem definition.

PMID- 1030507
TI  - [Tubo-ovarian abscess and pregnancy. Clinical case].

PMID- 1030508
TI  - [Fetal maturity tests, resolution of labor and results concerning the newborn
      infant in 91 cases of intrahepatic cholestasis in pregnancy].

PMID- 1030509
TI  - [Cardiac arrest. Clinical case].

PMID- 1030510
TI  - [Prolapse of the fallopian tube. Clinical case].

PMID- 1030511
TI  - [Infertility and cervical cerclage].

PMID- 1030512
TI  - [Use of 19-nor-17 alpha-hydroxyprogesterone caproate in endometrial cancer].

PMID- 1030513
TI  - [Stability of oil from the sunflower Helianthus annuus L. Action of
      antioxidants].

PMID- 1030514
TI  - [Oxygen absorption of a biodynamic system in a transitional regimen. I.
      Determination of operational parameters].
AB  - In this first of three parts, operational parameters (power consumption with and
      without aeration, aeration number, oxygen volumetric transfer coefficient and
      hold up) of the system used are presented, together with graphs and tables to
      show the relation between these parameters and controlable operating variables.
      Later the values here presented will be correlated with KLa determined by SOM,
      the kinetics of oxygen transfer in yeast cultures.

PMID- 1030515
TI  - [Influence of lactose rate on calcium fixation in bones. Study in rats].
AB  - This investigation was performed to study the effect of lactose on the fixation
      of calcium in bones of rats. Lactose 3% and 10% concentration was used and the
      action was compared to that obtained by 67 U.I. of vitamin D in 100 g diet. The
      data obtained indicated very definitely that the presence of lactose in the diet
      favorably influences the fixation of Ca in bone, when the amount is 10%; at 3%
      concentration lactose don't seem influence Ca fixation in bone.

PMID- 1030516
TI  - [Aminoaciduria screening in newborn infants using, comparatively, chromatographic
      and colorimetric methods].
AB  - The authors showed that the colorimetric methods used to effect aminoacidopathies
      screening are inadequate and unspecific. The thin layer chromatography was chosen
      to effect such screening and the authors showed the incidence in newborns of some
      aminoacid metabolism abnormalities.

PMID- 1030517
TI  - [Fatal traffic accidents in the South Moravian Region during 1964-1974 and their
      social consequences].
AB  - A statistical evaluation of 2,327 persons killed during or as a result of road
      accidents and post-mortem examined in the years 1964-1974 brought to light the
      fact that the actual number of those deceased was considerably higher than that
      quoted by official statistics. In this particular group there were 81 cases of
      people whose lives might have been saved provided they had been given immediate
      medical and technical aid. An examination of the social consequences of the above
      cases made it clear that approximately every 100 cases of adults killed in their
      productive age (16-60 years) were associated with 77 unilaterally orphaned
      children, or else that for every 100 persons killed that particular period of
      life there were about 5 completely orphaned children .--Any effort at eliminating
      the all too ofter unnecessary deaths of persons involved in road accidents then
      makes it absolutely imperative to establish an appropriate system enabling toe
      recruitment of immediate medical and technical aid.

PMID- 1030518
TI  - [Drugs and alcohol in 105 fatally injured participants of traffic accidents].
AB  - A total of 105 fatally injured participants of traffic accidents were examined
      for drugs and alcohol. Drugs were found in 12.38% subjects (12.5% drivers, 25%
      cyclists, 13.95% pedestrians and 9.09% fellow travellers). Drugs in combination
      with alcohol were found in 5.72% subjects, alcohol alone was detected in 21%. Out
      of 100 blood samples taken from living persons and sent for alcohol examination,
      drugs were found in 5 subjects. In 4 of them the alcohol level in the blood
      ranged from 0.67% to 1.64%.

PMID- 1030519
TI  - [Results of blood group evaluations in terms of expert opinion in disputes over
      paternity].
AB  - The author evaluates the results of control blood group estimations in the sense
      of supreme expertise in paternity cases as performed during 7966 through 1974. As
      ensues from the analysis, the percentage of unconfirmed eliminating conclusions
      remains to be high, i. e. 5,5%. Different findings as occurring in various group
      systems have been encountered in 284 cases. Therefore revision of eliminating
      couclusions cannot be abandoned.

PMID- 1030520
TI  - [Enuclation of the eye due to perforation injuries].

PMID- 1030521
TI  - [Different clinical manifestations of generalized forms of neuroblastoma in
      children and their treatment].

PMID- 1030522
TI  - Acute anaerobic necrotizing myositis treated with hyperoxia.

PMID- 1030523
TI  - [Parasitic diseases of the heart].

PMID- 1030524
TI  - [Determination of values of immunologically measurable insulin (IMI) in children
      with renal glycosuria].

PMID- 1030525
TI  - [Various problems in the diagnosis and treatment of patients with psychosomatic
      diseases].

PMID- 1030526
TI  - [Atrophy of the optical nerve and neurologic complications in polycythemia rubra
      vera].

PMID- 1030527
TI  - [A case of staphylococcal sepsis with benign tumor of the bronchus].

PMID- 1030528
TI  - [Diagnosis of rheumatic fever].

PMID- 1030529
TI  - [Radiological diagnosis of digestive-biliary fistula].

PMID- 1030530
TI  - [Traumatic rupture of the thoracic aorta in "closed" injuries of the thorax].

PMID- 1030531
TI  - [Incidence of otosclerosis in Serbia].

PMID- 1030532
TI  - [Metabolic liver diseases due to enzyme defects in carbohydrate metabolism].

PMID- 1030533
TI  - [Comparative analysis of healthy and osteomyelitic bone using electronic
      difraction].

PMID- 1030534
TI  - [Clinical evaluation of oncologic therapy].

PMID- 1030535
TI  - [Liposarcoma of the kidney in Bourneville's disease].

PMID- 1030536
TI  - [Moyamoya--multiple progressive intracranial arterial occlusions].

PMID- 1030537
TI  - [Albright's syndrome treated with calcitonin].

PMID- 1030538
TI  - Effect of postoperative hypoparathyroidism on bone density.
AB  - The mean radiographic vertebral density of permanently hypoparathyroid patients
      was elevated above the normal-for-age, while the vertebral density of transiently
      hypoparathyroid patients was normal. Of the patients who received desiccated
      thyroid, both the transient and permanent hypoparathyroid patients had
      significantly higher-than-normal vertebral densities (P less than 0.01 and P less
      than 0.02, respectively). The duration of thyroid treatment corresponded with the
      degree of hypermineralized vertebral density in the patients with permanent
      hypoparathyroidism and permanent hypothyroidism (r = .728, P less than 0.01).
      However, in the transient hypoparathyroid patients, no significant relationship
      was found between the duration of thyroid treatment and vertebral density. Visual
      assessment of spinal radiographs for incidence of vertebral compressions revealed
      no significant differences between hypoparathyroid patients and the controls. In
      the patients with transient and permanent hypoparathyroidism who received calcium
      and vitamin D, the initially depressed blood calcium levels were within normal
      limits at the follow-up observation, but the untreated permanent hypoparathyroid
      patients were still depressed.

PMID- 1030539
TI  - The Lx bodies of an eosinophilic granuloma in vivo and in vitro.
AB  - The ultrastructure of an eosinophilic granuloma is described. The typical tumor
      cell in vivo is the generally round histiocyte containing Langerhans cell type
      granules (Lx bodies), lamellar bodies, cytoplasmic clefts, and a markedly
      indented nucleus. In vivo, the Lx body was often continuous with the cell
      membrane, contained a typical periodic or nonperiodic median density, and had
      dilatations. Some dilatations were coated and similar to membrane-coated
      vesicles. The longest Lx body measured 4000 nm. After 18 days in culture, the
      ultrastructure of the histiocytes was similar to those in vivo. However, the Lx
      body in vitro had no association with the cell membrane, had no membrane coating,
      the median density was usually nonperiodic, and the longest body measured 7000
      nm. Lx bodies in vivo were occasionally associated with vesicles containing
      membrane-enclosed particles (70--80 nm in diameter) without dense cores, whereas
      the median density of some Lx bodies in vitro were associated with membrane
      enclosed particles (42--85 nm in diameter) with dense cores. Descriptions of the
      Lx body, its transformations in vitro, and its relation to lamellar bodies,
      membrane coated vesicles, and virus-like particles are the principal subjects of
      this report.

PMID- 1030540
TI  - The effect of angiotensin II on electrolyte excretion by the renal tubules.
AB  - In vivo studies were done on mongrel dogs to determine the effect of angiotensin
      II on renal electrolyte excretion. Angiotensin II was infused directly into the
      left renal artery at a rate of 1 ng/kg/min. Angiotensin produced consistent
      reductions in the excretion of Na+, K+, and Cl- in the left kidney. These
      reductions could not be attributed to decreases in GFR or RPF. Electrolyte
      excretion by the right kidney was constant. These data are consistent with the
      hypothesis that angiotensin II may function as an intrarenal, antinatriuretic
      hormone.

PMID- 1030541
TI  - Distribution of trace elements in the Houston environment: relationship to
      mortality from arteriosclerotic heart disease.
AB  - The relationship of trace elements to arteriosclerotic heart disease (AHD) was
      assessed. Samples of water supplies in the Houston area were analyzed
      periodically for cadmium, lithium, iron and zinc. Mortality data for each of the
      sampling areas, delineated according to boundary of water service, were used to
      compute average annual age-adjusted death rates for white males aged 35 to 64
      during the years 1969 to 1971. Linear regression analyses were performed on the
      chemical constituents for the age-adjusted death rates due to AHD. Positive
      correlation coefficients for lithium and zinc were found to be statistically
      significant at the 0.05 probability level.

PMID- 1030543
TI  - Transurethral surgical table.

PMID- 1030542
TI  - Renal autotransplantation: current perspectives.
AB  - Autotransplantation, with or without an extracorporeal renal operation, has been
      done 39 times in 37 patients. Indications for the procedure included severe
      ureteral injury in 4 patients, failed supravesical diversion in 2, renal
      carcinoma in a solitary kidney in 1, renovascular hypertension in 1 and donor
      arterial reconstruction before renal transplantation in 29. Success was obtained
      in all but 2 procedures, both of which involved previously operated kidneys with
      severe inflammation and adhesions involving the renal pelvis and pedicle. Based
      on our experience and a review of currently available literature we believe that
      renal autotransplantation and extracorporeal reconstruction can provide the best
      solution for patients with severe renovascular and ureteral disease not
      correctable by conventional operative techniques. The technique can be of
      particular value in removing centrally located tumors in solitary kidneys and in
      preparing donor kidneys with abnormal arteries for renal transplantation. The
      role of autotransplantation in the management of advanced renal trauma and
      calculus disease is less clear. A long-term comparison of patients treated by
      extracorporeal nephrolithotomy versus conventional lithotomy techniques will be
      necessary before a conclusion is reached in these disease categories.

PMID- 1030544
TI  - Hormones in renal cancer.
AB  - Plasma renin, erythropoietin and chorionic gonadotropin levels were evaluated in
      57 patients with renal adenocarcinoma. Renin elevation, found in 37 per cent, was
      unrelated to blood pressure levels but was associated with high grade, high stage
      lesions of mixed histologic cell type and predicted a poor prognosis.
      Erythropoietin was raised in 63 per cent of patients and was more sensitive than
      renin in indicating the presence of renal adenocarcinoma. However, it was less
      specific and did not correlate directly with tumor grade, stage, histologic type,
      prognosis or hematocrit and hemoglobin levels. None of the patients had elevated
      chorionic gonadotropin levels. Therefore, we believe that renin and
      erythropoietin determinations may be of value as biochemical tumor markers in
      renal adenocarcinoma.

PMID- 1030545
TI  - Results of non-operative management of blunt renal trauma.
AB  - A study of 84 patients with blunt renal trauma has revealed that expectant, non
      operative management of the clinically stable patient with either minor or more
      severe injuries (excluding vascular pedicle trauma) gives satisfactory results
      and entails few subsequent complications. The nephrectomy rate with expectant
      management is markedly lower than that reported after an immediate operation. The
      salvage of functioning renal tissue appears to be commensurate with angiographic
      delineation of devascularized tissue and would seem to be comparable to that of
      patients afforded immediate surgical intervention, without the threat of loss of
      the renal unit that appears to be entailed by early operation.

PMID- 1030546
TI  - Elevated urinary levels of 5-hydroxyindole acetic acid and its relationship among
      levels of plasma follicle stimulating hormone, testosterone and testicular
      pathology in patients with severe oligospermia and/or azoospermia.
AB  - Plasma follicle stimulating hormone, testosterone and urine 5-hydroxyindole
      acetic acid levels were measured in 300 patients seen at an andrology clinic.
      Testicular biopsies were obtained from many of the severely oligospermic or
      azoospermic patients. Plasma follicle stimulating hormone concentrations were
      related inversely to sperm cell concentration, while plasma testosterone
      concentrations were depressed as the sperm count decreased to 5 times 106 per ml.
      The urine levels of 5-hydroxyindole acetic acid followed the same pattern as
      follicle stimulating hormone and were elevated in the group of individuals with
      sperm counts less than 10 times 106 per ml. Elevations in 5-hydroxyindole acetic
      acid often were associated with abnormalities in the testicular biopsy. Only 30
      per cent of the patients who had elevated 5-hydroxyindole acetic acid also had
      elevated follicle stimulating hormone or depressed testosterone levels. The
      factors responsible for the elevation in 5-hydroxyindole acetic acid levels as
      the sperm count declines remain unclear.

PMID- 1030547
TI  - Motion picture: transpubic total prostatectomy.
AB  - The transpubic approach for total prostatectomy is ideal in cases involving small
      glands that have been resected and reported as stage A tumors. The approach also
      is ideal for stage B1 and B2 tumors. It allows great ease in the osmosis of the
      bladder to the urethra and dissection of the lymph nodes in the obturator and
      iliac areas.

PMID- 1030548
TI  - The continued evaluation of the effects of chemotherapy in patients with advanced
      carcinoma of the prostate.
AB  - The response and duration of survival were evaluated for patients with stage D
      relapsing prostatic cancer who were randomized to cyclophosphamide (Cytoxan),5
      fluorouracil (5-FU) or standard therapy, or to subsequent chemotherapies. The
      chemotherapies on initial randomization were superior to the standard therapy in
      the number of responders and duration of response. Survival was longer for
      responders (stable or partial regression) on chemotherapy by comparison to
      responders (stable only) on standard therapy. The survival for patients receiving
      initial and crossover chemotherapy was significantly improved for patients who
      responded to therapy. Chemotherapy of advanced relapsing stage D prostatic cancer
      is more beneficially treated by specific chemotherapy as shown in this randomized
      study.

PMID- 1030549
TI  - Thoughts on the prevention of urologic liability claims.
AB  - We have approached the problems of increasing urological liability claims with a
      superficial study of their causes and some suggested solutions. We believe that
      this approach is important because it is one that the urological community can
      take immediately rather than waiting for changes in state and federal laws that
      may be of benefit in decreasing the impact of these suits. It seems to be the
      common disease and the simple operation that lead to the lodging of a claim.

PMID- 1030550
TI  - Benzydamine: a new weapon in the treatment of interstitial cystitis.
AB  - Benzydamine hydrochloride was synthesized in 1966 and developed in Italy. It
      belongs to a chemical class that has not been used previously in the treatment of
      inflammatory conditions. Benzydamine is not related to steroids or other anti
      inflammatory drugs, it is given by mouth and its toxicity is low. A pilot trial
      was done in 25 cases of interstitial cystitis and virtually complete relief of
      pain was noted in 18 cases.

PMID- 1030551
TI  - Correlation of ureteral orifice position with renal morphology.
AB  - Double ureters and kidneys have provided models for the comparison of
      radiographic appearances and the microstructure of each renal segment, as well as
      the correlation with the position of the corresponding ureteral orifice. An
      orifice located within the limits of the normal vesical trigone portends normal
      renal radiography and morphology. Orifices outside the normal limits of the
      trigone signify accompanying renal malformations in the corresponding kidneys,
      such as hypoplasia or aplasia of nephrons that are often difficult to determine
      histologically but that give rise to thin kidneys and clubbed calices, dysplasia
      of nephrons and abnormal interstitial tissue and blood vessels, all of which are
      detected more readily on microscopic examination. The more abnormal the orifice
      is in location and characteristics the more abnormal are the ureteral and renal
      segments. The correlation also applies to upper tracts when they are associated
      with lower tract anomalies, such as congenital urethral valves, neuropathic
      bladders of myelomeningocele patients and paraureteral diverticula.

PMID- 1030552
TI  - Complications of single and multistage operations for hypospadias: a comparative
      review.
AB  - From 1970 through 1975, 198 children with hypospadias were operated upon at our
      clinic. Three basic types of primary urethroplasty were used: 1) a modified 2
      stage Cecil urethroplasty after separate straightening, 2) a modified 1-stage
      Denis Browne procedure after prior correction of chordee and 3) a 1-stage
      combined repair of hypospadias and chordee. A comparative review of early
      complications is presented.

PMID- 1030553
TI  - Motion picture: rectal bladder with Gersuny procedure after radical cystectomy.

PMID- 1030554
TI  - Roles for women health workers in the United States and China.

PMID- 1030555
TI  - Environmental carcinogens.

PMID- 1030556
TI  - Women and national health insurance.

PMID- 1030557
TI  - Government response to contraceptive and cosmetic health risks.

PMID- 1030558
TI  - Kanamycin as a Ca++ antagonist.

PMID- 1030559
TI  - Study on the fractionation of synovial fluid protein.

PMID- 1030560
TI  - Effect of hypertonic sucrose on the growth of Salmonella typhi in experimental
      blood cultures.

PMID- 1030561
TI  - Hematological aspects of congenital syphilis.

PMID- 1030562
TI  - Ventriculo-peritoneal shunting with one piece spring catheter: technical note.

PMID- 1030563
TI  - Critical review of shunting procedures for hydrocephalus.

PMID- 1030564
TI  - A study on the diverticular enlargement of the rat's submandibular duct (II).

PMID- 1030565
TI  - Central pressor actions of angiotensin II.
AB  - Involvement of the area postrema in experimental hypertension has been
      investigated. Ablation of the rear apex of the fourth brain ventricle (=the
      region of the area postrema) elevated blood pressure, heart rate and plasma
      angiotensin II level. The same characteristic changes were seen in the two kidney
      Goldblatt rat model of hypertension. A possible involvement of the area postrema
      in this model of hypertension is discussed. Intraventricular perfusion of
      angiotensin II elevated blood pressure without a significant change in heart
      rates. This pressor response appeared to be dependent on release of antidiuretic
      hormone. The results are discussed in relation to the intrinsic brain
      angiotensinogenase system.

PMID- 1030566
TI  - Iron absorption and loss in psoriasis.
AB  - 59Fe absorption has been studied in psoriatics to elucidate the iron deficiency
      state. To determine the rate of iron loss, elimination of injected 59Fe was
      measured. In psoriasis mean iron absorption did not differ from the mean in the
      normal group, but a pathologically low absorption was found in 8 cases. Iron loss
      was significantly higher in psoriatics than in normal men, while it did not
      differ significantly from iron loss in  women with regular menses.

PMID- 1030567
TI  - Indocyanine green plasma clearance in normal human males and females.
AB  - The plasma clearance of indocyanine green (Cardio-Green, 0.5 mg/kg body weight)
      was studied in a total of 352 plasma samples from 7 male and 8 female healthy
      volunteers, and total bilirubinaemia in 6 males and 6 females. Statistical
      analysis (linear regression, SAAM programmes by BERMAN and WEISS [2],t-test. F
      test and rank correlation) disclosed a significantly higher plasma disappearance
      rate of indocyanine green and significantly lower total bilirubinaemia in females
      than in males with a statistically almost significant negative correlation of
      both phenomena. A better excretion of indocyanine green from liver to bile in
      males though statistically significant could be an artefact caused e.g. by a not
      quite significant abnormally of the calibration straight line of the dye.

PMID- 1030568
TI  - DNA synthesis in cells of human tuberculous lymph nodes.
AB  - DNA metabolism of cells of tuberculous lymph nodes was studied
      autoradiographically with 3H-thymidine injected directly into one of the afferent
      lymph vessels. The undifferentiated mononuclear cells showed the most intensive
      DNA synthesis, but a large number of epitheloid cells had also become labelled.
      The nuclei of the giant Langhans cells took no label.

PMID- 1030569
TI  - Basal and insulin-stimulated glucose metabolism of isolated human fat cells.
AB  - Glucose-U-14C-activity added to the incubation medium of isolated human fat cells
      was studied for its conversion to CO2 and its incorporation into fat cell
      triglyceride. In view of the wide scatter of the figures found under basal
      conditions as well as in the presence of 100 muU/ml of insulin, the correlations
      of fat cell glucose metabolism to ponderal index, total body fat mass weight,
      mean fat cell diameter, fat cell TG-content and age were analysed. The activity
      of glucose metabolism in obese individuals was found to be inversely related to
      the degree of obesity under basal conditions as well as under the effect of
      insulin. According to partial regression analysis, of all these parameters it was
      the ponderal index which showed the most significant inverse correlation to the
      activity of fat cell glucose metabolism. No appreciable relationship was found
      between the production of CO2 from glucose and age. Incorporation of 14C-activity
      into fat cell triglyceride showed a slight age-related increase under basal
      conditions as well as on insulin stimulation. It is concluded that at the
      cellular level it is the triglyceride saturation of fat cells which constitutes
      the endogenous regulatory factor responsible for the impaired biological action
      exerted by insulin on the enlarged fat cells in obesity.

PMID- 1030570
TI  - Amniotic fluid total lipids, cholesterol, phospholipids and inorganic phosphorus
      in toxaemia of pregnancy.

PMID- 1030571
TI  - [Current status of prevention of infection in orthopedic surgery].

PMID- 1030572
TI  - Bacteriology and control of postoperative wound infection.

PMID- 1030573
TI  - [Prevention of postoperative infections without using antibiotics].

PMID- 1030574
TI  - [Kefzol in prophylactic treatment of orthopedic patients. Retrospective study
      with ampicillin].

PMID- 1030575
TI  - [Postoperative infections in orthopedics].

PMID- 1030576
TI  - [Significance of the sedimentation rate after osteosynthesis or arthroplasty].

PMID- 1030577
TI  - [Nonsurgical treatment of infectious arthritis caused by commonplace bacteria].

PMID- 1030578
TI  - [Treatment of early postoperative infection after osteosynthesis].

PMID- 1030579
TI  - [Infection in leg fractures].

PMID- 1030580
TI  - [The contribution of trochanteric-iliac coaptation in the treatment of infections
      after total arthroplasty of the hip].

PMID- 1030581
TI  - [Infectious arthritis complicating rheumatoid polyarthritis].

PMID- 1030582
TI  - [Pulmonary functional repercussions of simple forms of anthraco-silicosis].

PMID- 1030583
TI  - Some lungfunction studies on diffuse and bullous emphysema.

PMID- 1030584
TI  - [Incidence of chronic bronchitis among pigeon-breeders (author's transl)].

PMID- 1030585
TI  - [A histo-pathological study of the aetiology of pleurisy in the negro, with
      reference to sixty pleural biopsies performed by the Cope's needle technique
      (author's transl)].

PMID- 1030586
TI  - [Approach to the epidemiology of tuberculosis in the Liege region (author's
      transl)].

PMID- 1030587
TI  - Vascular calcifications and osteoporosis in diabetes mellitus. X-ray study.

PMID- 1030588
TI  - Effect of chemical radioprotection on radiation injury of chromosomes.

PMID- 1030589
TI  - The condition of motor cells in anterior horns of the spinal cord in relation to
      changes of inner structure of some muscles following denervation.

PMID- 1030590
TI  - Cell cycle dependent radiation injury of chromosomes in vivo.

PMID- 1030591
TI  - Education and measurement in educational therapy.

PMID- 1030592
TI  - The role of the educational therapist in adult education.

PMID- 1030593
TI  - Counseling issues in retinitis pigmentosa.

PMID- 1030594
TI  - Coordination of work therapy in rehabilitation.

PMID- 1030595
TI  - The limits of loyalty.

PMID- 1030597
TI  - Knowledge and the patient: factors influencing what the patient receives.

PMID- 1030598
TI  - Management by objectives: philosophy, theory, or technique?

PMID- 1030599
TI  - Cerebral palsy: the myth of a label.

PMID- 1030600
TI  - The educational system as a rehabilitative process: difficulties and
      alternatives.

PMID- 1030601
TI  - [Health problems connected with the industrial use of non-ionizing radiations].

PMID- 1030602
TI  - [Semiconductor probes for bio-medical uses].

PMID- 1030603
TI  - [Calibration of gel-chromatographic columns for examination of dextrans for
      clinical use].
AB  - A procedure is described which allows to obtain integral distribution in
      molecular weights for oligodextran preparations of clinical use from the elution
      profiles obtained by gel-filtration. The calibration procedure requires the use
      of commercially available dextran fractions with known distribution in molecular
      weight (the M.W. distribution of the standards may be checked through absolute
      determination of Mn and Mw). For given column dimensions and elution conditions,
      the outlined procedure yields an accurate plot of log Mw vs k (partition
      coefficient).

PMID- 1030604
TI  - [Automation in analysis. VII. Automatic mineralization and determination of
      organic phosphorus].
AB  - An automatic manifold for the organic phosphorus mineralization is described. The
      device at issue does consist in an electrically heated aluminium blok, in which
      80 holes are drilled, in order to hold 80 hydrolysis vials. The heating is
      automatically controlled by an independent unity. The ortophosphate determination
      is performed photometrically with the previously described automatic apparatus.

PMID- 1030605
TI  - [Endocrine tumors of the ovary. Histopathological findings].

PMID- 1030606
TI  - [Cytology of the sputum and bronchial aspiration in the diagnosis of thoracic
      diseases].

PMID- 1030607
TI  - [Problems of pleural cytology and histopathology].

PMID- 1030608
TI  - [Pathogenetic significance of lesions due to so-called hyalinosis in lymph node
      sarcoidosis].

PMID- 1030609
TI  - [Mesoblast, mesoepithelium and perithelium in the histogenesis of mesothelioma].

PMID- 1030610
TI  - [Various types of Brenner tumor as a cell-differentiation majority of an ovarian
      mesothelioma. A case of Brenner tumor with "stromal" cells and metastases in the
      omentum].

PMID- 1030611
TI  - [Small peritoneal tumors of the great gastric curve (solitary papillary
      mesothelioma, ganglioneuroma, fibroma): profile of pathological anatomy].

PMID- 1030612
TI  - [Bronchial cartilaginous dysgeneses and neoplasm-forming epitheliums].

PMID- 1030613
TI  - [Histopathological and ultrastructural aspects of the spleen in Cooley's disease
      under various conditions of transfusion and therapeutic treatment].

PMID- 1030614
TI  - [Recent contribution on the study of osseous echinococcosis. Anatomo-histological
      profile of a case with femoral localization, with special reference to granulo
      xanthomatous reactions].

PMID- 1030615
TI  - [Pneumosilicosis].

PMID- 1030616
TI  - [False-negative reactions in the diagnosis of hidden axillary -lymph-node
      metastases of mammary carcinoma].

PMID- 1030617
TI  - [The so-called mesonephric carcinoma of the uterus. Histopathological findings
      and histogenetic considerations].

PMID- 1030618
TI  - [Giant benign chondroma of the ribs (2 observations)].

PMID- 1030619
TI  - [Selection and acceptability of food].
AB  - In this paper the following factors which in one way or the other may have
      influence on the selection and acceptability of foods are treated: 1.
      Fisiological and psycological aspects; a) genetic factors, b) neurophysiological
      factors, c) emotional factors, d) perceptive factors. 2. Physical and ecological
      aspects. 3. Social and cultural aspects, a) habits and traditions, b) religious
      believes, c) tabues, d) nutrition faddism, e) prejudice, aversions and
      perversions, f) social value of foods, g) industrialized foods. 4. Economic
      aspects. 5. Educational aspects.

PMID- 1030620
TI  - [Dietary profiles according to socioeconomic levels in Honduras].

PMID- 1030621
TI  - [Development of a food formula (Fortesan) for preschool children].

PMID- 1030622
TI  - [Relationship between nitrogen retained in rats, determined by body nitrogen
      analysis and nitrogen balance].

PMID- 1030623
TI  - [Critical study of plasma nonessential/essential amino acid ratio, as a
      nutritional indicator, in surveys in Chile].

PMID- 1030624
TI  - [Relationship between bronchial asthma and infection: interference of various
      treatments].

PMID- 1030625
TI  - [Immune-surveillance and tumors: current concepts].

PMID- 1030626
TI  - [A case of primary pulmonary hemosiderosis].

PMID- 1030627
TI  - [Clinico-epidemiological findings on osteoarticular tuberculosis].

PMID- 1030628
TI  - [Modifications of serum immunoglobulins during a course of bronchopneumopathy].

PMID- 1030629
TI  - Investigations on the conservation of parahaemolytic vibrios by lyophilization
      and direct desiccation. (Preliminary note).

PMID- 1030630
TI  - Catalysome, an intra-lipochondrial microstructure of Acanthamoeba cells.

PMID- 1030631
TI  - [Isolation of preparative amounts of polyribosomes from normal rabbit and guinea
      pig spleen].
AB  - Preparative amounts of polyribosomes were isolated from normal rabbit and guinea
      pig spleen; up to 40 optical units of the polyribosome preparation could be
      obtained by centrifugation in a Spinco L-2B centrifuge with SW-27 rotor. The
      amount of polyribosomes isolated from spleens of immune animals was 2-3 higher
      than that isolated from normal animal spleens. Concentration of polyribosomal
      preparations by lyophylization and the storage of dried preparations do not alter
      the sedimentation properties of the polyribosomes. The distribution pattern of
      normal rabbit spleen polyribosomes in a linear sucrose gradient and the
      sedimentation constants of the polyribosome peaks are in good agreement with data
      reported by some other authors for plasmocytome polyribosomes. Using
      electrophoresis in agarose-polyacrylamide gel the radioactive proteins
      synthesized in the cell culture of normal rabbit spleen it was shown that in
      normal spleen the average amount of globulins makes up to 35% of total protein
      synthesis, as reported by some authors.

PMID- 1030632
TI  - [Application of phase partition method for the fractionation of hydrophobic
      membrane proteins].
AB  - Phase partition method in a two-phase polyethylene glycol-dextrane system has
      been applied to fractionation in Triton X-100 of hydrophobic membrane proteins
      from Micrococcus lysodeikticus. This method allowed to separate the cytochrome
      b556 from other cytochromes. Spectral and gel electrophoretic patterns of
      isolated cytochrome are given.

PMID- 1030633
TI  - [Proteins of bacterial membranes. Purification of NADH-dehydrogenase by
      electrofocusing].
AB  - A highly purified preparation of NADH dehydrogenase was isolated from bacteria M.
      lysodeikticus membranes. The purification procedure involved extraction of the
      enzyme complex from isolated membranes by EDTA, solubilization of the complex by
      non-ionogenic detergent (1% Triton X-100), chromatography on DEAE-cellulose and
      electrofocussing in the pH gradient 4-6. The isoelectric point of the preparation
      is at 4.5; its main component is a protein with m.w. of about 76.000.

PMID- 1030634
TI  - [Control of RNA biosynthesis in rat liver. Some features of RNA biosynthesis
      during prolonged protein synthesis inhibition].
AB  - A drastic inhibition of protein biosynthesis in rat liver in vivo by
      cycloheximide (CHI) (0.3 mg/100 g of body weight) first caused an increase of RNA
      synthesis (after 1 hour), which was then followed by its decrease. Partial
      gradual restoration of the protein synthesis level was shown to be accompanied by
      a repeated increase of RNA synthesis (12 hs) and its normalisation after 24 hs.
      The first maximum of RNA synthesis increase in the isolated nuclei system was AU
      type RNA synthesis (sensitive to alpha-amanitine), the second one was due to GC
      type RNA synthesis (resistant to this toxin). Purified chromatine template
      activity in the system with E. coli RNA polymerase (by 14%) an hour after CHI
      treatment, but 3 hrs later was decreased and subsequently restored (12 hrs after
      CHI injection). The changes of RNA biosynthesis induced by prolonged protein
      synthesis inhibition suggest the existence of continuous RNA synthesis control in
      nuclei. This control is realized by translation system using the feed back
      principle.

PMID- 1030635
TI  - [Steady-state kinetics of electron transfer through the cytochrome chain of
      uncoupled submitochondrial particles. General kinetic analysis].
AB  - Steady-state kinetics of electron transfer through the cytochrome chain of
      uncoupled ultrasonic submitochondrial particles at different pH values were
      studied. The rate constants calculated according to Pring's equation (k1=V/Prpoxt
      i+1) were found to increase linearly with the increase in the rate of electron
      transfer. Linearity was observed, however, only at relatively low rates of
      electron transfer. Several kinetic models were developed and analysed to fit the
      experimental data on the basis of the suggested activation of respiratory chains
      induced by their functioning. The best agreement with the experimental data was
      obtained with the model implying that the rate of activation of the electron
      carriers is directly proportional to the overall rate of electron transfer and
      the portion of non-activated respiratory chains in the system. It followed
      therefrom that electron transfer through already activated chains induced
      activation of adjacent non-activated chains. This model made it possiple to
      determine the rate constants for non-activated (ki) and activated (k) carrier
      states and the life-times of activated carriers (tau).

PMID- 1030636
TI  - [Effect of 2,4-diamino-5-chlorphenyl-6-ethylpyrimidine on the oncorporation of
      P32-phosphate into adenylic nucleotides of rat embryo and placenta].
AB  - Teratogenic doses of antimalaria preparation, 2,4-diamino-5-p-chlorophenyl-6
      ethylpyrimidine (chloridine), known in biochemistry as a specific inhibitor of
      dihydrofolate reductase, result in the decrease of 32P-phosphate incorporation
      into ATP and ADP, coupled with the inhibitions of DNA synthesis, in rat embryo
      and placenta on 13th day of development, while the incorporation of 14C-formiate
      into free nucleotides of acid soluble embryo and placenta fractions (at the same
      intervals after teratogen injections), is the same as in the control. These data
      show that the primary blocking of folate cycle and DNA biosynthesis in 13 days
      old embryos with induced anomalies of development is some way coupled with
      disturbances of ATP metabolism.

PMID- 1030637
TI  - [Localization of the Meler's reaction with ethanol catalase trap in the chain of
      photosynthetic electron transport].
AB  - The common view of photosystem I as the action site of catalase and ethanol at
      oxygen uptake in chloroplasts  are based on indirect data on this reaction. That
      is why the question on Mehler reaction localization in electron transport chain
      with ethanolcatalase trap has been investigated anew. It has been demonstrated
      that oxygen uptake with catalase and ethanol does not decrease in presence of
      dibromothymoquinone (2,5-dibromo-3-methyl-6 isopropyl-p-benzoquinone--DBTQ) which
      blocks electron transfer to photosystem I at plastoquinones level. The summation
      of oxygen uptake activities is observed on the combined action of catalase and
      ethanol with any of the Mehler reagents functioning in photosystem I
      (methylviologen,FMN, epinephrine, ferredoxin). Catalase and ethanol in contrast
      to methylviologen have no effect on photooxidation rate of reduced
      dichlorphenolindophenol in photosystem I. The quatum yield of oxygen uptake with
      catalase and ethanol versus wave length of actinic light shows a distinct maximum
      in the photosystem II absorption area and a "red drop" in the longware area. The
      obtained data show that the Mehler reaction with catalase and ethanol takes place
      in photosystem II only.

PMID- 1030638
TI  - [Acetylcholinesterase of cobra venom. Determination of concentration of active
      sites].
AB  - O-Nitrophenyl dimethylcarbamate and organophosphorus inhibitors O-n-propyl-p
      nitrophenyl methylphosphonate, O-n-butyl-p-nitrophenyl methylphosphonate, O,O
      diethyl-p-nitrophenyl phosphate, O-n-butyl-S-(beta-ethylmercaptoethyl)
      methylthiophosphonate, methysulphate of O,O-diethyl-S-(beta
      phenyldimethylammoniumethly) thiophosphate were used in the titration of
      acetylcholinesterase active site concentratration in Naja naja oxiana venom. No
      side reactions with the acetylcholinesterase molecule as well as with other
      components of the venom were observed. In titration the effective concentrations
      of organophosphorus inhibitors with asymmetric phosphorus were 50% of their
      analytical concentrations, since cobra venom cholinesterase showed practically
      absolute stereoselectivity against the compounds.

PMID- 1030639
TI  - [Lipid-mobilizing activity of a synthetic peptide identical to 33-44 fragment of
      human growth hormone].
AB  - The lipid-mobilizing activity of a synthetic peptide, NH2-Phe-Glu-Glu-Ala-Tyr-Ile
      Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-COOH, corresponding to the 31-44 amino-acid
      sequence of human growth hormone, was studied. The peptide stimulated lypolysis
      upon administration to fasted rats and during incubation with isolated epidiymal
      adiposed tissue of rat and perirenal adiposed tissue of rabbit. The lipid
      mobilizing effect of the peptide,unlike the corresponding effect of the native
      growth hormone, developed fast and was markedly pronounced 15-30 min after the
      incubation was started. Direct dependence between the peptide dose logarithm and
      the effect studied was observed at concentrations of 0.01-10microng/ml during
      incubation with rat adipose tissue and at 0.001-0.1 microng/ml during incubation
      with rabbit tissue.

PMID- 1030640
TI  - [Characteristics of the activity of "satellite" enzymes of gluconeogenesis in the
      oocytes and embryos of loach].
AB  - The activity of "satellite" enzymes related to gluconeogenesis has been measured
      in the oocytes and embryos at the early stages of loach (Misgurnus fossilis L.)
      embryogenesis. The activity of pyruvate dehydrogenase increase during oocyte
      maturation by 30%, remains constant at the cleavage and blastula stages and
      decreased on the onset of gastrulation. In the both oocytes and embryos pyruvate
      dehydrogenase has been found only in the active form. The activity of citrate
      synthase, malate dehydrogenase and pyruvate carboxylase remained constant during
      oocyte maturation and et all early stage of embrional development. Citrate lyase
      and "malic"-enzyme were not found, Oocyte maturation is followed by a
      considerable increase in the malate and oxalacetate content, the level of
      pyruvate and acetyl-CoA being found invariable.

PMID- 1030641
TI  - [Molecular hybridization of native and modified subunits of lactate dehydrogenase
      isoenzymes and aldolase A in rats].
AB  - Experimental conditions for the molecular hybridization in vitro between iodine
      and native subunits of isoenzymes 1 and 5 of lactate dehydrogenase (LDH) are
      described. It is also shown that the covalently fixed on the polyacrylamide beads
      rat J125 labelled LDH-5 and J125 labelled aldolase A, under conditions of
      complete dissociation of the quaternary structure of these enzymes, only one of
      the four subunits remain bound with the beads. Subunit of LDH-5, which is
      covalently bound with the polyacrylamide beads, is capable to hybridize
      (reassociated) with 3 native subunits. In addition, the immobilized LDH-5
      subunits and aldolase A are capable to hybridize with J125 labelled subunits of
      these enzymes. Thus, when thyrosine, lysine and N-terminal amino acids are
      modified, subunits of LDH-5 and aldolase A retain their capacity to restore their
      quaternary structures.

PMID- 1030642
TI  - [Beta-cyanoalanine synthase: Its purification and basic physico-chemical
      properties].
AB  - A method has been developed for the purification of beta-cyano-L-alanine synthase
      from etiolated 10-day-old seedlings of blue lupine. High purity preparations of
      the enzyme were obtained with specific activity exceeding 4000-fold that of the
      seedling homogenate. Preparations were homogeneous on electrophoresis in
      polyacrylamide gel. The yield of total activity after purification was
      approximately 20%. Glutamic acid is the enzyme's only N-terminal amino acid; the
      molecular weight of the enzyme (both native and treated with 6 M urea) is 52000.
      The synthase containes one mole of pyridoxal-P per mole of protein; its
      isoelectric point is situated at pH 4,8. The enzyme's absorption spectrum has a
      maximum at 410 nm i.e., in the characteristic range of many pyridoxal-U
      containing enzymes. Data on the amino acid composition of the enzyme are
      presented.

PMID- 1030643
TI  - [Plasma kallikrein: new functions].
AB  - The literature data on some new functions of human plasma kallikrein have been
      discussed. The role of kallikrein as an enzymatic activator of Hageman factor in
      fluid-phase was emphasized, and the description of this effect, brought about by
      a feedback mechanism was given. These new findings stress the importance of
      plasma kallikrein in the initiation of kinin-forming, intrinsing clotting and
      fibrinolysis. The chemotactic activity of the kallikrein molecule for human
      neurophiles was considered. New data were given concerning Hageman factor as
      proteinase and its substrates in human plasma-coagulation factor XI (PTA),
      plasminogen proectivator and prekallikrein.

PMID- 1030644
TI  - [The change of template activity of dog kidney chromtin by polyene antibiotics in
      vivo and in vitro].
AB  - Effect of amphotericin B and nistatin on template activity of nuclear membrane
      bound (DNPm) and free (DNPo) dog kidney chromatin after intravenous injections of
      antibiotics and after the incubation of isolated kidney cell nuclei with the
      antibiotics is studied. It is found that injections of amphotericin B and
      nistatin resulted in the increase of DNPo template activity in RNA polymerase
      system, the stimulating effect of nistatin being higher than that of amphotericin
      B. Injections of nistatine stimulated also template activity of DNPm, while
      amphotericin B produced no effect on DNPm. When studing the effect of polyene
      antibiotics on template activity of DNPo and DNPm in vitro, it is found that the
      intensity of RNA synthesis after incubation of isolated nuclei with antibiotics
      is considerably increased, and stimulating effect of nistatin is higher than of
      amphotericin B. Both antibiotics produced no effect on template activity of DNP
      in vitro. Thus, comparative analysis of changes in template activity of dog
      kidney chromatin under the effect of polyene antibiotics in vivo and in vitro has
      revealed the similarity of these drugs and draws to the conclusion that nistatin
      and amphotericin B produce a direct effect on template activity of chromatin.

PMID- 1030645
TI  - [Cooperative interaction of pyruvate dehydrogenase from pigeon breast muscle].
AB  - Cooperative interaction of pyruvate with the pyruvate dehydrogenase (PD) complex
      from pigeon breast muscle was shown. The sigmoidal dependence of the reaction
      rate on pyruvate concentration was observed for the PD complex. The Hill
      coefficient is equal to 1,5; no inhibition by the substrate (up to 2.2.10(-3) M)
      was found. The kinetic behaviour of the isolated pyruvate dehydrogenase component
      (PDH) analyzed under similar conditions, is more complex; this may be probably
      due to the presence of oligomeric forms with different molecular weights and
      specific activities. The competitive inhibitor of the PD complex--an amide of
      pyruvic acid (PA) (Ki=6.3-10(-6) M) activates the enzyme at low concentrations
      (less than 2,10(-6) M). When PA is present, the dependence of the reaction rate
      on pyruvate concentration gives a usual hyperbolic curve, v of [S]o. It is
      concluded that pyruvate may have a regulatory effect on the activity of muscle PD
      complex.

PMID- 1030646
TI  - [Interrelationship between protein synthesis and mRNA metabolism in rat liver
      cells].
AB  - It is demonstrated that RNA isolated from polyribosomes and postmitochondrial
      fraction of rat liver cells and bound to nitrocellulose filters (Milliport)
      represent mRNA. RNA taken from the nitrocellulose filters sedimented in sucrose
      concentration gradient with a wide peak within the range of 18--6S, attaining a
      maximum at 12S. The (A+U)/(G+C) ratio of this RNA was equal to 1.04. On the other
      hand, the same ratio for rRNA was 0.64. Specific radioactivity of polysomal mRNA
      containing poly-A sequences, was significantly lower at 14-hour labelling with
      14C-orotate than at 4-hour labelling (control). Inhibitors (cycloheximide,
      puromycin, ethionine, actinomycin D) stabilized polysomal mRNA. Specific
      radioactivity of postmitochondrial fraction mRNA was higher at 14-hour labelling
      than at 4-hour labelling. Specific radioactivity of postmitochondrial fraction
      mRNA during protein synthesis blocking by different inhibitors was comparable to
      those of control animals. It is hypothesized that active translation is necessary
      for the initiation of rat liver mRNA degradation.

PMID- 1030647
TI  - [Isolation of a neutral histone-hydrolyzing protease from bovine spleen].
AB  - Neutral histone-hydrolyzing protease has been isolated by fractionation of bovine
      spleen extract. The low level of the protease activity in the extract may be due
      to the presence of an inhibitor. The enzyme activity was increased 100--1200-fold
      during ammonium sulfate fractionations, gel filtration on Sephadex G-100 and G
      75, chromatography on CM- and DEAE-celluloses. The protease was detected in the
      fraction with a molecular weight lower than 25000. The enzyme was markedly
      activated by dithiothreitol and EDTA and inhibited by p-chloromercuribenzoate and
      iodoacetic acid. It was also inhibited by N-tosyl-L-lysyl chloromethyl ketone, N
      tosyl-L-phenylalanyl chloromethylketone, bovine blood serum and partially by
      soybean trypsin inhibitor DFP, trasylol and epsilon-amino caproic acid had no
      effect. Beside histone, the neutral protease hydrolyzed casein and gamma-globulin
      and fibrinogen in a low extent. The enzyme had no activity toward N-benzoyl-D,L
      arginine p-nitroanilide, N-benzoyl-L-arginine ethyl ester and N-acetyl-L-tyrosine
      ethyl ester, collagen, elastin and fibrin. Some properties of the enzyme were
      similar to those of neutral SH-dependent proteases described by Hayashi and Lo
      Spalluto et al.

PMID- 1030648
TI  - [Functional characterization of the creatine phosphokinase reactions in heart
      mitochondria and myofibrils].
AB  - The kinetic properties of MM-isozyme of creatine phosphokinase (CPK) bound to
      heart myofibrils have been determined experimentally. It has been shown that CPK
      isozymes bound to the heart myofibrils and mitochondria are electrophoretically
      different, but have very similar kinetic properties. For both isozymes the ATP
      formation reaction is preferable. However, in heart mitochondria the kinetic
      properties of CPK are compensated for by a tight functional coupling with ATP-ADP
      translocase. Due to this coupling the ATP formed in the course of oxidative
      phosphorylation can be used completely for creatine phosphate production in
      mitochondria. On the other hand, the kinetic properties of myofibrillar CPK
      isozyme are such that they provide for the effective utilization of creatine
      phosphate produced in mitochondria for rephosphorylation of AKP formed in the
      myofibrils during contraction. It is concluded that in the heart cells energy can
      be transferred from the mitochondria to the myofibrils by creatine phosphate
      molecules.

PMID- 1030649
TI  - [Interaction of electrophilic alkylating agents with nucleophilic sites of
      mitochondria].
AB  - The electrophilic alkylating agents having different numbers of electrophilic
      groups with nucleophilic sites of mitochondria were studied. Bifunctional
      compounds were found to modify the structure of mitochondria so that some of the
      sulfhydryl groups become inaccessible for titrating ions of Ag+. Monofunctional
      agents caused no changes in the number of determinable sulfhydryl groups and
      prevented the effect of bifunctional compounds. The linkage formed between the
      electrophilic residue and the nucleophilic site is stable in the absence of
      electron transport. During the transport of electrons in the respiratory chain
      the linkage becomes labile and the electrophilic residue chips off. A scheme of
      interaction of electrophilic alkylating agents with nucleophilic sites of
      mitochondria is proposed.

PMID- 1030650
TI  - An attorney's approach to psychiatrists in custody cases.
AB  - The contested custody case has in common with any other case that it is a search
      for the truth through the medium of the courts. Many modern thinkers believe that
      the courts are not the proper arena for discovering the truth in all cases.
      Increasingly, there is agitation to remove areas of testimony from the courts,
      placing them perhaps in the hands of some commission appointed by government. So
      far, this has not happened in the area of child custody, and we still have the
      courtroom technique of examination and cross-examination, with a final decision
      by a judge on the basic subject of truth, that is, what is the best interest of
      the child. The attorney can learn from the doctor in this process, and I think
      the doctor can learn from the courts. I hope the day will come when no
      psychiatrist will ever say that he is too busy to take the patient's case if it
      is likely to involve him in legal controversy. I hope the time will come when no
      psychiatrist will say that he will not become involved with a case unless he can
      do so as an appointee of the court as opposed to a doctor employed by one of the
      parties. I hope the doctor will look forward to providing testimony and that some
      of the thoughts expressed in this discussion will make his day in court a better
      experience for him.

PMID- 1030651
TI  - Carcinoembryonic antigen in patients with untreated central nervous system
      tumors.
AB  - This study was designed to determine whether immunological examination of
      carcinoembryonic antigen (CEA) levels in blood serum and cerebrospinal fluid
      would be helpful in detecting central nervous system tumors. Forty patients with
      tumors of the central nervous system were compared with 108 control patients. The
      findings suggest that: 1) CEA determinations are not helpful as a screening test
      in detecting preclinical central nervous system tumors; 2) Serum CEA
      determinations may be useful in determining the presence of a malignant tumor in
      patients with a circumscribed uptake on brain scan or a nonspecific mass lesion
      at cerebral angiography; 3) Cerebrospinal fluid CEA determinations were of no
      value in detecting central nervous system tumors; 4) Further study on a larger
      population of malignant central nervous system tumors is warranted.

PMID- 1030652
TI  - Congenital facial neuropathy in oculoauriculovertebral dysplasia-hemifacial
      microsomia (Goldenhar-Gorlin syndrome).
AB  - Four patients with clinical features of Goldenhar-Gorlin syndrome who showed
      facial paralysis on clinical examination are presented. The fourth case died
      following surgery for cleft lip. Autopsy revealed hypoplasia of the right facial
      nerve in its intracranial segment, with small right facial nucleus in the brain
      stem. Nosological aspects of the Goldenhar-Gorlin syndrome are discussed.
      Peripheral facial paralysis, as a part of this syndrome, is reviewed in the light
      of clinical and pathological findings and in its relationship to cardiac
      anomalies. It is suggested that Goldenhar-Gorlin syndrome is a part of a so
      called cardiofacial syndrome.

PMID- 1030653
TI  - Alternating Bell's palsy associated with diabetes mellitus. A report of four
      cases.
AB  - Four diabetic patients are presented with alternating facial palsy. The term
      alternating is meant to imply facial nerve paralysis, the onset of which occurs
      at different points in time on both sides of the face. Clinical findings are
      presented and a short review of the literature is summarized. The authors
      conclude that alternating facial palsy is often associated with diabetes
      mellitus. Alternating facial palsy is an infrequent finding. This is in marked
      contrast to the unilateral form. Approximately every 13 minutes someone in the
      United States incurs idiopathic facial paralysis or Bell's palsy (20 persons per
      100,000 per year). It is apparent that the majority of unilateral facial palsies
      fall into the idiopathic category. The alternating form of facial paralysis,
      however, appears to be an unusual finding in a symptom complex of several
      diseases which will be discussed. It is the diagnostic significance of this
      alternating facial paralysis and its occasional association with diabetes
      mellitus that prompts this report.

PMID- 1030654
TI  - The measurement of spatial contrast sensitivity in cases of blurred vision
      associated with cerebral lesions.
AB  - Thirty-five patients with known cerebral lesions complained of recently acquired
      blurred vision. None of them had evident oculomotor or pupillary abnormalities,
      and each had intact central fields and normal visual acuity by conventional
      standards. Examination of spatial contrast sensitivity was carried out with
      sinusoidal grating patterns, by determining the minimum contrast between
      alternate light and dark bars required to distinguish the pattern from a
      homogeneous field. This was done at each of several spatial frequencies which
      were established by varying the width of the bars and hence the coarseness of the
      pattern. The contrast sensitivities were plotted as "visuograms" which, by
      analogy to audiograms, record the sensitivities in comparison to normal
      standards. Of the 35 patients, most showed significant losses, amounting to
      greater than 50 per cent elevation of contrast thresholds. Eighteen showed high
      frequency losses; 11 had uniform reductions over the entire visible spatial
      frequency range and 6 had selective frequency losses in the intermediate
      frequency ranges. These defects in spatial contrast sensitivity, which were not
      predictable from standard acuity scores, indicate that the visual symptoms in our
      patients may have been caused by damage to frequency-selective neural elements in
      the central visual systems. The method may be used to advantage in clinical
      investigations as well as in physiological investigations of the functional
      pathways subserving central vision.

PMID- 1030655
TI  - Primary cerebral neuroblastoma. A clinicopathological study of 35 cases.
AB  - A series of 35 primary cerebral neuroblastoma is reported. These rare tumours
      occur most often in children in the first half of the first decade. Grossly the
      tumors are often massive, discrete, lobular, firm and cystic. Histologically
      three variants, largely determined by the extent and distribution of the fibrous
      connective tissue stroma, are recognized: (1) a classical variant, which most
      resembles the peripheral neuroblastoma and is characterized by a high frequency
      of Homer Wright rosettes and a relatively high frequency of ganglionic
      differentiation; (2) a desmoplastic variant, which is characterized by an intense
      connective tissue stroma; and (3) a transitional variant, in which both the
      classical and the desmoplastic features may be present within the same case,
      either concurrently or consecutively. Both the desmoplastic and the transitional
      forms are less likely to exhibit differentiation to mature ganglion cells, but
      the importance of identifying the primitive cell elements as neuroblasts is
      emphasized. With rare exceptions, this can be established only by specific silver
      impregnations on frozen material. Occasionally the direction of growth may be
      largely leptomeningeal. Seven illustrative clinical histories with pathological
      correlations are described. The over-all clinical behaviour of these tumours is
      that of malignant neuroepithelial neoplasms, characterized by a high recurrence
      rate. Recurrence may, however, be a late development, in some cases occurring
      five or seven years after apparently successful surgical removal. The tumour
      shows shows a high incidence of metastatic spread, almost 40 per cent of the
      cases examined at autopsy having disseminated in the cerebrospinal pathways.
      Exceptionally, extraneural metastases may also develop. However, long post
      operative survival occasionally occurs, and the subsequent clinical course is not
      always predictable in the individual case. The differential diagnosis is briefly
      discussed. The cellular nature of the tumour and its biological behaviour recall
      those of the cerebellar medulloblastoma. Post-operative radiation to the entire
      neuraxis should be considered for these neoplasms.

PMID- 1030656
TI  - Enhanced pressor response to noradrenaline in patients with cervical spinal cord
      transection.
AB  - Arterial blood pressure, heart-rate and the electrocardiogram were recorded in
      subjects tetraplegic from cervical spinal cord transections, and in control
      subjects, before, during and after intravenous infusions of 1-noradrenaline. Over
      a wide range of doses the blood pressure rose much more in the tetraplegics than
      in the controls. Circulating noradrenaline during infusion did not significantly
      differ between the two groups. The findings indicate that tetraplegic subjects
      have an enhanced pressor response to noradrenaline infusions. Such a response
      therefore does not necessarily indicate post-ganglionic sympathetic denervation.
      The observed responses in the tetraplegics may in part be due to exaggerated
      adrenergic receptor responses, but the main cause is likely to be the loss of
      those baroreceptor reflexes with sympathetic efferent pathways.

PMID- 1030657
TI  - Radiculomyelitis following acute haemorrhagic conjunctivitis.
AB  - The clinical manifestations and natural history of radiculomyelitis following a
      newly reported disease--acute haemorrhagic conjunctivitis (AHC)--have been
      studied in 33 patients in Taiwan, and the following observations made: All the
      patients in this series were adults at ages ranging from 21 to 55 years; the
      salient initial neurological manifestations were radicular pains and acute
      flaccid paralysis which developed from five to thirty-seven days after the onset
      of AHC. In some patients, signs and symptoms indicating involvement of the
      meninges, cranial nerves and the white matter of the cord were observed; motor
      paralysis was the most striking feature during the whole clinical course; it
      consisted of flaccid asymmetrical weakness in one or more limbs, usually being
      more severe in the lower limbs than in the upper, and often more proximal than
      distal. Atrophy in the severely affected muscles usually became apparent in the
      second or third week of the weakness; the prognosis regarding the return of
      function in the affected muscles was dependent on the severity of the
      involvement. Permanent incapacitation due to paralysis and muscular atrophy in
      the affected proximal muscles of lower limbs was the main sequel in severe cases.
      The pattern and prognosis of flaccid motor paralysis were reminiscent of acute
      poliomyelitis in which the anterior horn cells of the spinal cord are mainly
      involved. Pleocytosis ranging from 11 to 270 per mm3 was noted in the majority of
      the patients when the cerebrospinal fluid was examined within the first three
      weeks from the onset of neurological symptoms; the total protein level was raised
      invariably from the second week onwards in all specimens, and remained so
      throughout the subsequent course as long as the seventh week or later. Tissue
      culture neutralization tests were performed on the sera from 9 patients;
      significant rises in the antibody titres (greater than or equal to 1:16) to AHC
      virus antigens were found in 8 cases, and in 2 of them a fourfold rise in the
      paired sera was noted. The differentiation of this syndrome from poliomyelitis
      and from Guillain-Barre syndrome, the relative freedom of children from
      neurological complications of AHC and the aetiological relationship of AHC virus
      to the syndrome have been discussed. It is concluded that this unusual
      neurological syndrome is caused by the neurovirulent properties of the AHC virus.

PMID- 1030658
TI  - Learning and insight in psychotherapy.
AB  - The main objectives of this paper are: (a) an overview of therapeutic parallels
      and differences between psychoanalytic and behavioral psychotherapy; (b) an
      analysis of learning process with reference to insight taking place during
      psychotherapy. For attaining these objectives, the author reviews the literature
      and explores the cognitive and educational values inherent in the
      psychotherapeutic process.

PMID- 1030659
TI  - [Aggression].
AB  - The aggressiveness is not a drive and has nothing in common with Freudian death
      instinct, but it is one of the ways to fulfill the possession desires and the
      narcissistic desires. As the way to achievement, it comes into a conflict with
      the fear of failure, with the co-operation advantages and with the altruistic
      human drives. As the latter ones are rather weak in an average person, the co
      operation--as a basis of society--is in all its strata imbued with aggression.
      Each social structure, up to the present day, has contained aggression as an
      organic component. The hope of creating a society free from aggression is not
      based on the betterment of the human character, but on the growth of the
      productive forces. The existence of the interpersonal aggression has been
      concealed from a child, brought up in the spirit of the centuries-old fallacious
      educational principles. As a result, the child develops its first neurosis--the
      Superego neurosis. The Superego is not a structural component of the human
      psyche, but it is a neurotic formation. In the subsequent years, the
      confrontation of the child and the youth with the true aggression may affect his
      or her development in various ways. In some cases, the given individual
      disregards the Superego commands and pays for it with the neurosis of permanent
      guilt feelings. In other cases, the individual deals with the Superego as with
      the ethical values in themselves, and develops an inhibition neurosis
      (Gehemmtheitsneurose). Still in other cases he or she revolts against the
      mendacity of the society and develops a pseudopsychopathy. The proper education
      should strive to awake the nobe feelings in the child, but at the same time to
      reveal the whole truth about the existence of aggression in the human
      interrelations. In these conditions, through the conscious choice between the
      egoistic and the altruistic drives, could the growing person form the moral
      attitudes fitting his or her own nature. Because the ethics of the values in
      themselves is but a philosophical fiction, the only real ethics is that which is
      based on feelings.

PMID- 1030660
TI  - Hypnotic recall and flashback: the remembrance of things present.
AB  - There are two kinds of flashbacks: the self-programed or intra-individual variety
      and pre-programed or inter-individual flashbacks re-presenting mythical and
      narrative event structures which contribute to the survival of the species. Both
      types of experiences are arousal-state bound and stage (set and setting) or
      culture bound. Flashbackers may be characterized by (1) their variability (large
      SD) on perceptual-behavioural tasks pointing to their extensive cognitive or
      interpretive repertoire, (2) they are minimizers (or reducers) of sensory input
      (particularly at the peak of a hallucinogenic drug experience), (3) as a group
      they display high resting heart rates, (4) are hypnotizable and experience), (3)
      as group they display high resting heart rates, (4) are hypnotizable and hence
      (5) prefer righ cerebral hemispheric cognition, (6) displaying EEG-alpha
      dominance in the resting, waking state. Flashback and hypnotic recall differ only
      in the ways and means by which they are induced. Hypnotic induction, however, is
      not to be confused with the induced state that may be any ordinary or non
      ordinary state of consciousness on the perception-hallucination-meditation
      continuum which the subject has a least once experienced before. If mind is an
      open system comprising the individual's mind and the minds of his total
      environment, i.e. his past and present sets and settings, then for many of us
      thoughts and actions are hypnotically induced, and memories are flashbacks of
      those experiences.

PMID- 1030661
TI  - The hyperkinetic child syndrome: the need for reassessment.
AB  - The dramatic increase in the incidence of hyperkinesis witnessed in recent years
      constitutes a growing concern for the children so classified. Some relevant
      issues are discussed in terms of (a) diagnostic practices, (b) treatment
      practices, and (c) changing views about the nature of the disorder itself. Rather
      than focusing on the child as a source of the problem (as has typically been the
      case), future research and practices need to demonstrate a broad-based
      perspective on the adjustment problems of these children that examines
      "situational" determinants and institutional policies.

PMID- 1030662
TI  - Chronobiological pattern of growth hormone secretion in normal subjects and in
      retinopathic diabetics. Lack of suppression by a plurichronocorticoid drug.
AB  - Nyctohemeral variations in plasma concentrations of HGH, glucose, and FFA were
      studied in 22 normal subjects and 48 diabetic patients affected with retinopathy.
      In the normal subjects, (fourteen males and eight females, mean age 40+/-3 years;
      body weight less than 110% of I.B.W.) the determinations were made on blood
      samples drawn every hour. Seven of these normal subjects were examined before and
      after 10 days of administration of a new plurichronocorticoid drug (administered
      at 08(00) and 15(00), with a total amount of 14 mg of prednisolone and 15 mg of
      cortisone). In patients with diabetic retinopathy (32 male and sixteen female
      patients, mean age 46+/-2 years, body weight less than 110% of I.B.W.) the
      determinations were made on blood samples drawn every 3 hrs. All the diabetic
      patients were insulin treated and were under good or discrete metabolic control,
      and presented advanced retinopathy. Both in the normal subjects and in
      retinopathic diabetics, the mean HGH curve showed a characteristic elevation
      during the early nighttime hours (between 21(00) and 02(00). Despite higher
      values in plasma glucose and FFA, in diabetics the nocturnal elevation of HGH was
      only slightly lower than in the normals. The comparison between daytime and
      nighttime determinations, both in the normal subjects and in the diabetics,
      reveals statistically significant differences. These results suggest that in
      subjects with diabetic retinopathy, in the phase of good or discrete metabolic
      control, spontaneous HGH secretion is not increased, and that nocturnal elevation
      of HGH is not substantially influenced by higher plasma levels of glucose and
      FFA. Ten days of plurichronocorticoid treatment with a new drug which exhausts
      its activity before the evening, did not modify the circadian rhythm of HGH.

PMID- 1030663
TI  - Isotope lymphography of the retrosternal region.
AB  - The authors have examined 150 patients with Hodgkin's lymphomas and cancer of the
      breast and lung. They consider indirect lymphography as a screening method
      necessary to be completed with available clinical examinations. In normal
      scintigram it is possible eliminate the pathological process. Even when some part
      of lymphatic region is not scanned it is possible to say that the suspicion of a
      pathological process is highly probable. It is necessary to consider the
      anatomical variability of lymphatic vessels. Therefore, the scintigram must be
      evaluated together with other clinical findings. The examination of axillar and
      cervical area of lymphatic system and the determination of eventual collateral
      circulation is recommended simultaneously with retrosternal lymphography.

PMID- 1030664
TI  - Control of the RIA method as viewed from the standpoint of the investigation on
      the kinetics of the insulin-125 I-antibody reaction.
AB  - In this paper attempts were made towards the optimalization and the control of
      some parameters of the RIA reaction. Basing on the law mass action, as well as on
      the Scatchard's and Sip's equations, the equilibrium constants for the reversible
      reaction: insulin-125I-antibody for different incubation temperatures were
      calculated. Moreover a characteristic of the antiinsulin antibody by means of the
      "alpha"heterogeneity coefficient was done, as well as the values of the
      thermodynamic function increments were calculated, which made possible to point
      out explicitly the optimal shape of the standard curve.

PMID- 1030665
TI  - A rational approach to "in vitro" thyroid function testing.
AB  - A system of "in vitro" thyroid function testing is proposed whereby laboratory
      staff select the most appropriate screening test depending on the information
      supplied by the clinician. Total serum triiodothyronine (T3) or thyroxine (T4)
      are used for screening as appropriate. In borderline cases, secondary tests are
      performed automatically according to a flow chart. This system improves
      efficiency and is cost effective, saving approximately 1,800 pounds annually in a
      laboratory handling about 5,000 requests for thyroid function tests each year.

PMID- 1030666
TI  - Experiences with the use of the 131I-hippuran test as an indicator in functional
      patency of ventriculocardiac shunts in hydrocephalic children.
AB  - In this paper a method is presented that provides information on the function of
      ventriculocardiac shunts in hydrocephalic children. There is good correlation
      between clinically and operatively demonstrated obstruction of the shunts as well
      as with clinically found free C.S.F. passage through the shunt. However, the
      greatest benefit is provided with the aid of the present method in cases with
      equivocal obstruction of the shunt where in our experience some operations of the
      shunt could be postponed or completely avoided in some cases. Because of its
      simplicity, safety, rapidity, and easy repeatability the method is recommended
      for routine ambulatory and hospital use.

PMID- 1030667
TI  - [Influence of antidepressants on the convulsive action of corazole and
      strychnine].
AB  - The influence of 10 antidepressants on an experimentally induced convulsive
      syndrome in mice was studied. It was found that, as concerns their ability to
      have an effect on DL50 of metrasol, the depressants may be classified into drugs
      protecting mice against the action of metrasol (melipramine, amitryptiline,
      chlorprothixen and phthoracizine), those potentiating the effect of metrasol
      (insidon, phrenolon, iproniazide, nuredal) and drugs producing no essential
      effect on DL50 of metrasol (desipramine, sonapax). All of the above drugs had an
      effect of decreasing the mean lethal dose of strychnine.

PMID- 1030668
TI  - [Effect of gamma-aminobutyric acid on peripheral mechanisms regulating autonomic
      functions].
AB  - Experiments with cats ascertained the potentiating action of GABA (100,300,500
      mg/kg) on the pressor reactions of the small intestine vessels, the systemic
      arterial pressure, depressing (100 mg/kg) and facilitating (500 mg/kg) effect
      upon the reactions of inhibition of the small intestine motor activity evoked by
      the efferent stimulation of the celiac nerve. Adrenolytics (dihydroergotoxin,
      inderal) abolished the facilitating effects of GABA. The latter (0.01 solution)
      inhibited spontaneous contractions of isolated small intestine lengths. As proved
      histochemically GABA (500 mg/kg) reduces the catecholamines content in the
      suprarenals, in the solar plexus ganglia and in vessles "in vivo". It also
      increases the catecholamines content in the small intestine wall in experiments
      in vivo and reduces in vitro tests. The potentiating action of GABA on the
      vegetative reactions in efferent stimulation of the ciliac nerve occurs,
      apparently, due to an increased ejection of catecholamines by suprarenals and
      lowered the content of catecholamines in the solar plexus ganglia, which causes
      facilitated conduction of excitation in the ganglia.

PMID- 1030669
TI  - [Anabolic activity of phytoecdysone-ecdysterone isolated from Rhaponticum
      carthamoides (Willd.) Iljin].
AB  - Introduction of phytiexdizone-exdisterone (0.5 mg/100 g) to rats for 7 days is
      shown to be attended by an accelerated body weight gain and also by a rising
      weight of the liver, heart, kidneys and musculus tibialis anterior. In these
      organs the total amount of protein increases. All of the above-stated changes are
      more marked when the substance is given to growing rats (70--80 g). In
      experiments on castrated sexually immature rats the androgenic action of
      exdisterone, unlike that of methandrostenolone, is not demonstrable.

PMID- 1030670
TI  - [Bioneutralizing properties of antibodies to serotonin].
AB  - Experiments conducted on rabbits demonstrated formation of antiserotonin
      antibodies in response to introduction to the animals of a serotonin-proteinic
      conjugate. The effect of antibodies on the development of a serotonin- and
      dextran-induced inflammation in rats and on the serotonin level in cells of
      slices of their organs, as well as in the blood thrombocytes was studied. The
      antibodies were found to produce an antiphlogistic effect in regard to exogenous
      (serotonin-induced) and endogenous (dextran-induced inflammation) serotonin.
      Histochemical investigations showed the antibodies to exert a neutralizing action
      on intracellular serotonin.

PMID- 1030671
TI  - [Influence of the functional state of the endocrine glands on the toxicity and
      accumulation of lithium in rats].
AB  - Hypophysectomy, adrenalectomy, introduction of desoxycorticosterone-acetate
      (DOCCA) and aldosterone facilitate cummulation of lithium in the organs and
      plasma of rats subjected to the action of lithium chloride, whereas
      thyroidectomy, administration of triiodothyronine, hydrocortisone and aldactone
      fail to influence this process. The toxicity of lithium chloride for animals
      increases with hypophysectomy and adrenalectomy, remains unchanged with
      introduction of DOCCA, triiodothyronine and thyroidectomy and subsides under the
      effect of hydrocortisone.

PMID- 1030672
TI  - [Dynamics of nonachlazine distribution in several rat organs following single and
      repeated administration].
AB  - Dynamics of nonachlazine, a new anti-anginal agent, distribution in organs
      following its single and repeated introduction in the form of a potion and
      aqueous solution was studied in tests with albino rats. It was ascertained that
      on introduction of a ready for use medicinal preparation (potion) the drug is
      absorbed by the blood and enters internal organs at a quicker pace than does its
      aqueous solution. The type of the medicinal preparation of the drug has no
      relevance to the rate of its elimination from the organism. With its repeated
      introduction (over a space of 12 days) the nonachlazine level in the heart and
      kidneys goes up, whereas its content in the blood and liver experiences but a
      slight change.

PMID- 1030673
TI  - Definitions and terminology in cancer (tumor) etiology--an analysis aiming at
      proposals for a current internationally standardized terminology.
AB  - The Committee on International Collaborative Activities (CICA) of the
      International Union Against Cancer (UICC) has decided to attempt to provide a
      current international standardized terminology in cancer (tumor) etiology, in
      cooperation with the International Agency for Research on Cancer (IARC) and the
      Worlk Health Organization (WHO). As a first stage of this attempt and to
      encourage international discussion, CICA has requested one of its members, the
      author, to formulate and publish under his responsibility the present analysis
      and proposals. The present paper to be published in a number of cancer journals
      outdates all of its previous versions or drafts.

PMID- 1030674
TI  - HeLa cell-tumor in nude mice and its response to antitumor agents.
AB  - HeLa cells were heterotransplanted to nude mice and their response to some of
      antitumor agents was investigated. HeLa cell-tumor readily grew in nude mice and
      no regression was observed. Metastases to the lung and other organs were noticed
      in some of the animals. Histopathological examination revealed that the tumor
      retained the original characteristics of human epidermoid carcinoma.
      Standardization of HeLa cell-tumor in nude mice for the screening and evaluation
      of antitumor chemotherapeutics was attempted. Marked inhibition of tumor growth
      was observed with lower doses of Mitomycin-C, 5-fluorouracil, Adriamycin, and
      Bleomycin. The tumor regression was observed with high doses of Mitomycin-C,
      Adriamycin, and 5-fluorouracil. However, cyclophosphamide, cytosine arabinoside,
      and daunorubicin had little effect on the tumor growth. Complete regression was
      not obtained with any of the test agents and active regrowth took place even with
      the most effective compound. Considerable variation in the effect on tumor growth
      was observed among the test compounds, while histopathological findings were much
      alike; few mitotic figures, vacuolization, and pyknosis were main changes in
      tumor cells, and large foci of necrosis and hemorrhage were present in the
      degenerative areas. The regrowth was initiated around the capillaries in the
      necrotic tumor tissue.

PMID- 1030675
TI  - Cytotoxic activity of lymphocytes to bronchogenic carcinoma cells in patients
      with lung cancer.
AB  - Cytotoxicity of peripheral blood lymphocytes against a cultured cell line QG-56
      of a bronchogenic squamous cell carcinoma was studied by a microcytotoxicity test
      in 33 cases of bronchogenic carcinoma. An augmented cytotoxicity was detected in
      the patients in early stages of the disease as compared to normal controls or the
      patients carrying other types of tumors. The cytotoxicity declined as the stages
      of cancer advanced. The patients with high degree of cytotoxicity appeared to
      show better clinical course after radiotherapy.

PMID- 1030676
TI  - Effect of a sulfated polygalacturonic acid on the proliferation of cells in
      culture.
AB  - The effect of a low molecular weight sulfated polygalacturonic acid on the growth
      of BALB/c 3T3 cells and HeLa cells was examined. This chemical reduced the
      saturation density of 3T3 cells in the range of concentrations of 10(-4) to 1
      mg/ml, and inhibited the proliferation of HeLa cells, causing little or no cell
      damage. Treated cells began to grow after removal of the sulfated
      polygalacturonic acid. Treatment with this acid also induced enlargement of the
      cell size in 3T3 cells, and a marked reduction of colony size and of central
      piling up in HeLa cells. 35S-sulfated polygalacturonic acid was bound to the
      cells immediately. Electrophoretic mobility of both cell lines treated with this
      sulfated polygalacturonic acid increased the negative charge of the cell surface.
      These evidences suggest that sulfated polygalacturonic acid affects the cell
      surface, restricting the cell growth of both cell lines.

PMID- 1030677
TI  - Tumors of the upper digestive tract of ACI/N rats given N-propyl-N-nitrosourethan
      in the drinking water.
AB  - Three groups of ACI/N rats of both sexes were given 400, 200, or 100 ppm of N
      propyl-N-nitrosourethan (PNUR) continuously in the drinking water. The incidence
      of tumors in the upper digestive tract was 100% in all 3 groups. These tumors
      were observed most frequently in the forestomach, followed by the esophagus, oral
      cavity, and pharynx. Histologically, all the tumors were papillomas or squamous
      cell carcinomas. A few tumors were detected in the small intestine and glandular
      stomach. The study on morphogenesis of squamous cell carcinomas arising from the
      upper digestive tract indicates that the majority of tumors of the esophagus and
      forestomach may pass through acanthosis or hyperkeratosis, leukokeratosis, and
      papilloma, and finally develop into invasive squamous cell carcinoma, but many
      carcinomas of the oral cavity and pharnyx, especially the tongue, may develop
      without passing through a papillomatous stage.

PMID- 1030678
TI  - Properties of thymidine kinase partially purified from human adrenal glands.
AB  - Thymidine kinase was partially purified from human adrenocortical carcinoma,
      hyperplasia, and normal adrenal glands. For the purpose of clarifying the
      qualitative and quantitative difference of thymidine kinase between cancer and
      normal tissue, biochemical properties of partially purified thymidine kinase were
      compared. Adrenocortical carcinoma and hyperplasia contained greater
      concentration of thymidine kinase than normal adrenal gland. By the DEAE
      cellulose chromatography, adrenocortical carcinoma gave two peaks (Peak I and
      Peak II) of thymidine kinase, while in hyperplasia and normal adrenal gland, the
      second peak (Peak II) was only slightly detected or hardly detected. Thymidine
      kinase in these three glands was identical with respect to pH optimum and
      inhibition by dTTP, but inhibition by dCTP was quite different. dCTP inhibited
      the activity of normal adrenal gland and Peak II of adrenocortical carcinoma by
      55% and 40% at 0.1 mM, respectively, but the activity of adrenocortical
      hyperplasia and Peak I of adrenocortical carcinoma was hardly affected. Normal
      adrenal enzyme was more stable against heat inactivation than adrenocortical
      carcinoma and hyperplasia. The apparent Km with thymidine for Peak I and Peak II
      of adrenocortical carcinoma, hyperplasia, and normal adrenal gland was 5.0, 11.1,
      5.1 and 25.0 x 10(-6)M, respectively.

PMID- 1030679
TI  - Comparison of the manifestation of radiation-induced lethal damage in in vitro
      and in vivo systems.
AB  - The kinetics of radiation-induced cell death was compared in in vitro and in vivo
      systems, using mouse mammary carcinoma cell line, FM3A. Cultured and ascites
      cells were irradiated with 5 krad of X-rays, and changes in the number of viable
      cells and in the cell volume after irradiation were analyzed. The volume of
      irradiated cells in both systems increased about 5 times that of control after 3
      generations and was saturated. Cells in vitro began to die after 3 generations.
      The number of cells in vivo began to decrease immediately after irradiation, but
      the rate of the decrease became large at 3rd generation. It was concluded that
      radiation-induced lethal damage manifests itself in the same way at the
      intracellular level in both systems, and some dying cells in vivo were eliminated
      before manifestation of lethal damage.

PMID- 1030680
TI  - Tumour-associated hepatocellular mitosis in Ehrlich ascites tumour-bearing mice.
AB  - The hepatocellular mitotic response associated with Ehrlich ascites tumour is
      mediated by the tumour less than 48 hr, but more than 18 hr prior to the time of
      observation (day 8 of tumour growth). Tumour-associated hepatocellular motisis is
      normally centrilobular in distribution and appears to involve marginally more of
      the liver lobule than is sensitive to the necrotic effect of CCl4. There is
      failure to summate mitotic activity when both tumour-associated hepatocellular
      mitosis and regenerative hepatocyte motisis would be expected to occur; in this
      situation regenreative heaptocyte mitosis is the overwhelming contributor to the
      observed mitotic index. It is postulated that tumour-associated hepatocellular
      mitosis is obligatorily centrilobular. Tumour-associated hepatocellular mitosis,
      on the evidence of the present work and the results of others using
      intraperitoneally administered proteolytic enzymes as inducers of hepatocyte
      mitosis, is considered to be systematically mediated; there is complete failure
      to observe any perilobar preponderance of mitotic activity. This implies an
      indirect effect of tumour in producing the hepatocyte mitogen. Criteria obtained
      from the present work are suggested as useful in any attempt to isolate and
      identify the true or in vivo tumour-associated mitogen, and would help to exclude
      possible non-specific mitogens.

PMID- 1030681
TI  - [Heinz body formation and abnormal methemoglobin reduction. Expressions of damage
      to erythrocytes in chronic kidney failure].
AB  - Erythrocytes of patients dialyzed due to chronic renal failure were investigated.
      An inhibition of the NADH-dependent methaemoglobin reductase, an insufficient
      methaemoglobin reduction by the NADPH-system, and Heinz-bodies as denaturation
      products, were found. The damage of erythrocytes was enhanced by incubation in
      both patient's plasma and dialysis medium. In erythrocytes of normal persons the
      damaging effect of incubation in plasma of chronic renal failure patients could
      also be demonstrated. The factors eliciting the oxidative injury are discussed.
      Factors that could further decrease the reduction capacity of red cells should be
      omitted.

PMID- 1030682
TI  - Accumulation and localization of lead in Eisenia foetida (Oligochaeta) tissues.
AB  - 1. Accumulation and distribution of lead in tissues of Eisenia foetida
      (Oligochaeta) living in soils with different concentrations PbO2 was studied
      histochemically and with the use of the dithizione method. 2. The earthworms
      absorb lead from the soil through the alimentary canal as well as through the
      body wall. this leads to considerable accumulation of this metal in epithelial
      cells, especially in the epithelial gland cells of the body wall and of the
      alimentary tract. 3. High concentration of lead in the soil does not favour
      increased accumulation of lead in the earthworms' organisms. The histochemical
      data show that the most intense accumulation occurs when the concentration of
      PbO2 is 0-4 mg/1-00 g soil.

PMID- 1030683
TI  - Ultrastructure of the chorionic villus of the human placenta of the second and
      third trimester pregnancy.
AB  - 38 human placentae of the 14th week of normal gestation were studied
      ultrastructurally. The thickness of the syncytial layer of villi varied markedly,
      and the syncytial cytoplasm showed marked vacuolization, which increased in the
      course of pregnancy in association with intensification of processes of
      resorption and absorption and hormonal function of the syncytium. Toward the end
      of the 2nd and at the beginning of the 3rd trimester of pregnancy, hypertrophic
      cytotrophoblastic cells appeared, whose ultrastructural character indicated
      functional stimulation. This observation contradicts the widely held view that
      cytotrophoblastic cells undergo gradual reduction in the course of pregnancy.

PMID- 1030684
TI  - Characteristics of drug abuse patients at a Veterans Administration Hospital.
AB  - A total of 308 patients were treated at the Wood VAC Drug Treatment Center during
      its first 2 years of operation (November 1, 1971-October 318 1973). They
      completed confidential questionnaires upon admission. Personal information and
      data concerning drug usage were obtained. Significant findings include the
      following: 1. A wide variety of opiate and nonopiate drugs were available in the
      military. 2. Although most patients had experienced illicit drugs prior to
      service, over 60% tried heroin for the first time while in the military; 83% of
      these men were subsequently treated for opiate dependence. 3. High rates of
      unemployment, marital instability, and convictions for illegal activities were
      revealed. A significant proportion of first convictions occurred prior to major
      drug usage. Data suggest that a flexible and multimodal approach to drug abuse
      therapy may have the best potential for success. Problems in evaluating and
      coordinating drug treatment programs are discussed briefly.

PMID- 1030685
TI  - Psychological testing and the detection of drug abusers.
AB  - Empirical studies using psychological tests for the detection and early
      identification of drug abusers are summarized. Although the emphasis is on
      personality testing, intelligence and special aptitude tests are included. The
      author concludes that psychological testing has not been successful in
      differentiating drug abusers from other sampled groups. The ARCI and MMPI
      personality tests show potential, but their validity remains to be fully
      demonstrated. Factors for their lack of success include subjects with different
      "response sets" and in specific institutionalized settings. Recommendations for
      additional research in noninstitutional environments are discussed.

PMID- 1030686
TI  - Two contrasting alcoholism treatment programs: a comparison of outcomes.
AB  - Participants in two 60-day alcoholism treatment programs with contrasting
      treatment philosophies and rationale were followed-up 1 year after discharge from
      the hospital. Widely different results were obtained with distinctly different
      alcoholic veteran populations. Response to treatment was highly favorable for
      less symptomatic alcoholics when direct emphasis was place upon the alcoholism
      per se and complete abstinence. Less favorable responses were achieved with overt
      neurotic alcoholics when treatment was designed to resolve underlying personality
      disturbances. Self-reports of marked depression, anxiety, and prior treatment for
      alcoholism were three pretreatment variables found significantly related to
      unsuccessful drinking outcome. The implication of these findings is that
      treatment outcome is largely dependent upon both the characteristics of the
      population treated and the treatment approach.

PMID- 1030687
TI  - Student drug use: attitudinal, parental relations, and sex differences--a pilot
      study.
AB  - Student drug abuse and its relationship to attitudes held by the abuser, sex
      differences,and the abuser's relationship to his parents were studied. The Parent
      Child Relations Questionnaire and four Smantic Differnetials regarding the "real"
      me, the perceived me, the immediate world and the drug addict were employed.
      Subjects were divided into present, past, and never users. Results indicated
      striking sex differences as well as differences between female present and never
      users with respect to all the attitudes investigated and the perceived
      relationship with the mother. It was hypothesized that the etiological factors
      surrounding female drug use may be psychodynamic in nature while the etiological
      factors for male drug use may be environmental.

PMID- 1030688
TI  - Studies on the nicotine exposure of individual smokers. I. Changes in mouth-level
      exposure to nicotine on switching to lower nicotine cigarettes.
AB  - Twenty-four subjects smoked two brands of filter-tipped cigarettes delivering
      different amounts of nicotine, on the following 4-week schedule: 1. Smoking their
      usual brand for 1 week. 2. Smoking another brand similar in size, but delivering
      less nicotine, for 2 weeks. 3. Reverting to their usual brand for 1 week. The
      amount of nicotine entering the mouth, defined as the mouth-level exposure, was
      estimated from a determination of the amount of nicotine trapped in the filter of
      each cigarette smoked. The results indicate a substantial variation in mouth
      level exposure for the subjects studied, even among smokers of cigarettes that
      deliver similar amounts of nicotine when smoked on a machine under standard
      conditions. For the majority of subjects, however, changing to a lower nicotine
      cigarette reduced the total daily mouth-level exposure to nicotine and,
      therefore, presumably the total tar intake.

PMID- 1030689
TI  - Criminality and addiction.
AB  - This follow-up study describes the criminal activity of samples of 112 dropouts
      and 110 active patients from one of the largest methadone maintenance programs in
      New York City. Certain refinements in the categorization of "dropouts" and in the
      calculation of crime rates are proposed that appear necessary if different drug
      treatment modalities are to be compared. Considering the rates for property
      offenses committed during the year following admission to the program, the
      highest rates are among the court cases included in the sample of active
      patients, followed by the dropouts who were in institutions at the time of the
      interviews, and the dropouts who went to other methadone programs. The data
      suggest that methadone alone, without adequate supportive services, will not
      solve the crime problem and may even exacerbate it, at least for some groups of
      addicts. The need to monitor, alter, and improve treatment programs is
      emphasized.

PMID- 1030690
TI  - Frequency and magnitude distribution of life change in heroin and alcohol
      addicts.
AB  - A study of the frequency and magnitude of life change in two Veterans
      Administration Hospital addiction groups was made. Both heroin and alcohol
      addicts were characterized by a high frequency and magnitude of life change. The
      life change was highly correlated between the two addictions and there were no
      significant differences. This kind of evaluation is seen as important in
      identifying areas in which social disruption is concentrated and as an aid to
      organizing treatment in a way that is acceptable and nonthreatening to the
      patient.

PMID- 1030691
TI  - Benzidine and congeners: analytical chemical properties and trace analysis in
      five substances.
AB  - Spectrophotofluorimetric (SPF) methods are described for the trace analysis of
      benzidine, 3,3'-dimethylbenzidine, 3,3'-dimethoxybenzidine, and their
      dihydrochloride salts in microbiological growth media, waste water, potable
      water, human urine, and rat blood. The salient elements of the methods for these
      known or suspected carcinogens are: extraction of the residues as the free amine
      with benzene, rapid cleanup on an alumina column, and quantification of the free
      amine in methanol via SPF. Potable water solutions of the salts are diluted with
      buffer (pH-4) and quantified directly by SPF. Ancillary analytical information
      concerning the solubility and stability of these compounds in water, p-values,
      gas chromatographic analysis of the free amines, and thin layer chromatographic
      data in ten solvent systems are also presented.

PMID- 1030692
TI  - Determination of cadmium in the livers and kidneys of puffins by carbon furnace
      atomic absorption spectrometry.
AB  - A carbon furnace atomic absorption procedure is described for the determination
      of cadmium in the livers and kidneys of puffins, fratercula arctica. Samples are
      dried and weighed and 2 to 100 mg are dissolved in sulphuric and nitric acids.
      These solutions are analysed directly in the carbon furnace against aqueous
      standards and provide accurate results in the range 0-1 to 100 micrograms/g dry
      weight. The method is simple and rapid and requires much less of the small total
      sample than would be required for flame atomic absorption.

PMID- 1030693
TI  - Interferon synthesis in mouse peritoneal cells damaged by X-irradiation.
AB  - NDV-induced interferon of peritoneal cells of irradiated (X-rays, 400 R) and
      control mice was investigated in vitro. Irradiation or treatment with hydroxyurea
      (10(-5) M) and mitomycin C (25 microng/ml) did not change interferon synthesis in
      spite of an 80--90% inhibition of 3H-thymidine incorporation. Increased doses of
      mitomycin C and treatment with actinomycin D and puromycin blocked interferon
      production. De novo interferon synthesis occurred in cells with damaged
      replicative activity of DNA caused by irradiation or by treatment with
      antimetabolites.

PMID- 1030694
TI  - Evidence against the postulated identity of e-antigen with DNA polymerase
      associated with the hepatitis B candidate virus.
AB  - Partially purified preparations of e-antigen, obtained from sera of hepatitis B
      antigen carriers, were chromatographed on columns of immobilized single- or
      double-stranded DNA or on pyran-Sepharose. e-Antigen did not adsorb to any of
      these columns under conditions appropriate for the retention of various nucleic
      acid polymerases. Therefore, e-antigen and the DNA polymerase associated with
      Dane particles can be regarded as distinct proteins.

PMID- 1030695
TI  - The mortality component of health status indexes.
AB  - The mortality component of contemporary health indexes is discussed. Since these
      indexes reduce to mortality indexes when only life and death states enter the
      analysis, they share the conceptual weaknesses of mortality indexes. Also, they
      do not incorporate consumption variables explicity and therefore provide no
      structure for relating health status and living standard. Some attention is
      devoted to methodological problems of assessing survival probabilities, either
      from survey or experimental data or from beliefs of experts or individuals who
      are affected directly. The final section deals with individual preferences for
      survival lotteries. Conceptual weaknesses of common indexes are discussed,
      several canonical models for survival preferences are presented, the
      interdependence of individual utilities is discussed, and methods for eliciting
      individual survival preferences are considered, along with some illustrative
      empirical results.

PMID- 1030696
TI  - Scales for measuring general health perceptions.
AB  - This article reports on the construction and testing of eight health perception
      scales from 32 items on a standardized survey instrument designed for self
      administration, the Health Perceptions Questionnaire (Form II). The scales
      measure perceptions of prior health, current health, health outlook,
      resistance/susceptibility to illness, health worry/concern, sickness orientation,
      rejection of sick role, and attitude toward going to the doctor. Field testing
      revealed that the scales are valid, reliable, and stable over time for diverse
      populations. It is recommended that the scales be used in studies requiring
      general health measures. Suggestions for future research are offered.

PMID- 1030697
TI  - Income group differences in relationships among survey measures of physical and
      mental health.
AB  - The present research tested the hypothesis that the experience of health is
      hierarchically organized such that gratification of physical health needs must
      precede gratification of mental health needs. It was reasoned that because the
      nondisadvantaged possess greater resources for the gratification of health needs
      in general, symptoms of mental illness would be more salient for this group and
      thus better able to explain variance in both mental and physical illness. On the
      other hand, it was reasoned that symptoms of physical illness would be more
      salient and thus better able to explain variance in both mental and physical
      illness for the disadvantaged. Results of the study indicate income group
      differences in patterns of relationships among health variables, supporting the
      hypothesis and suggesting important differences in the validity of health
      measures across income groups. The results are related to previous findings in
      medical sociology, and suggestions for future research are made.

PMID- 1030698
TI  - The K index: a proxy measure of health care quality.
AB  - An index of health care quality is described that requires data on "sentinel
      health events"--unnecessary death and disability caused by specific ICDA-coded
      conditions on which medical agreement can be reached about avoidability of
      negative outcomes. The proposed index combines measures of incidence, severity,
      and concentration of sentinel health events in communities and compares the
      measures with mean values for a group of normative communities, to arrive at
      index values that are distributed as X2 for a group of communities with regard to
      the mean health conditions experienced by the normative communities. Calculation
      of the index is illustrated with hypothetical data, and problems of selecting
      normative communities are discussed.

PMID- 1030699
TI  - Predicting self-assessed health status: a multivariate approach.
AB  - Two-stage multivariate analysis was used to examine factors affecting personal
      perception of health status. In the first stage, sociodemographic variables were
      used as independent variables in Automatic Interaction Detector (AID) analysis in
      order to partition the study sample (11,153 civilian noninstitutionalized adults
      aged 58-63) into subgroups. In the second stage, binary multiple regression
      analysis was performed on each AID subgroup and on the total sample. Predictors
      used were indicators of psychological, socioeconomic, and sociomedical well
      being. Finally the applicability of these indicators in classifying persons in
      one of the two categories of perceived health status was examined by discriminant
      function analysis. Sociomedical health indicators were better explanatory
      variables of self-assessed health status than socioeconomic or psychological
      indicators of well-being.

PMID- 1030700
TI  - Health status: types of validity and the index of well-being.
AB  - The concept of validity as it applies to measures of health and health status is
      examined in the context of a set of standard, widely accepted definitions of
      validity. Criterion validity is shown to be irrelevant to health status measures
      because of the lack of a single specific, directly observable measure of health
      for use as a criterion. To overcome this problem, the Index of Well-being has
      been constructed to fulfill the definition of content validity by including all
      levels of function and symptom/problem complexes, a clearly defined relation to
      the death state, and consumer ratings of the relative desirability of the
      function levels. Data from a two-wave household interview survey provide
      convergent evidence of construct validity by demonstrating an expected positive
      correlation of the Index of Well-being with self-rated well-being and expected
      negative correlations with age, number of chronic medical conditions, number of
      reported symptoms or problems, number of physician contacts, and dysfunctional
      status. Discriminant evidence of construct validity is demonstrated by predicted
      differences in correlation between concurrent Index of Well-being scores and self
      assessed overall health status, and between the Index of Well-being scores and
      self-rated well-being on different days. A simple method of estimating a
      currently usable comprehensive population index of health status, the Weighted
      Life Expectancy, is described.

PMID- 1030701
TI  - A comparative study on somatic treatment and comprehensive treatment of bronchial
      asthma.
AB  - Asthmatic patients who were treated at our hospital for at least 3 months and for
      whom a follow-up was conducted were divided into 2 groups according to their
      attitudes toward psychotherapy: Group I who accepted psychotherapy and Group II
      who did not accept it as part of our comprehensive approach. We examined the
      differences in therapeutic results in these two groups obtaining the following
      information: (1) No significant differences was found between Groups I and II as
      to the onset age, family history, type, severity, laboratory findings, etc. (2)
      In Group I, no significant difference was found in therapeutic results as to the
      onset age, type of asthma, its severity, etc. (3) In Group II, a significant
      difference was observed in the therapeutic results as to the onset age, type of
      asthma and its severity. These findings were almost identical to the literature
      of the internal medicine field. (4) The difference in therapeutic results of
      Groups I and II was assumed to be related to the use of psychotherapy when
      psychological factors were present. (5) Although psychotherapy was shown to be
      effective in the treatment of bronchial asthma, we need to be aware that there is
      often initial resistance to the process and a tendency for patients to terminate
      prematurely.

PMID- 1030702
TI  - The smooth muscle cell. III. Elastin synthesis in arterial smooth muscle cell
      culture.
AB  - Primate arterial smooth muscle cells and skin fibroblasts were examined for their
      ability to synthesize elastin in culture. In the presence of the lathyrogen beta
      aminopropionitrile, the smooth muscle cells incorporate [3H]lysine into a lysyl
      oxidase substrate that was present in the medium and associated with the cell
      layer. A component having a mol wt of 72,000 and an electrophoretic mobility
      similar to that of authentic tropoelastin was isolated from the labeled smooth
      muscle cells by coacervation and fractionation with organic solvents. In the
      absence of beta-aminopropionitrile, long-term cultures of smooth muscle cells
      incorporated [14C]lysine into desmosine and isodesmosine, the cross-link amino
      acids unique to elastin. In contrast, no desmosine formation occurred in the
      fibroblast cultures. These characteristics demonstrate that arterial smooth
      muscle cells are capable of synthesizing both soluble and cross-lined elastin in
      culture.

PMID- 1030703
TI  - Purification from black widow spider venom of a protein factor causing the
      depletion of synaptic vesicles at neuromuscular junctions.
AB  - The aqueous extract of the venom glands of black widow spiders was fractionated
      on a column of Sephadex G-200 and then on a column of DEAE-Sephadex A-50 pH 8.2.
      A protein fraction was obtained that caused a great increase in the frequency of
      occurrence of miniature end plate potentials at the frog neuromuscular junction,
      and caused swelling of the nerve terminals and depleted them of their vesicles.
      The fraction consists of a least four protein components that are similar in
      their molecular weights (about 130,000) and isoelectric points (ranging from pH
      5.2 to 5.5) and are immunologically indistinguishable. It contains no sugar
      residues and has little or no lipolytic or proteolytic activity. The fraction is
      toxic to mice and is different from the fractions that act on houseflies, the
      crayfish stretch receptor and the cockroach heart. It seems pure enough to
      warrant a detailed study of its site and mode of action.

PMID- 1030704
TI  - Evidence for RNA linked to nascent DNA in HeLa cells.
AB  - Rapidly labeled, i.e., nascent, DNA from HeLa cells was separated from the bulk
      DNA by ultracentrifugation. Further characterization of the rapidly labeled
      component revealed that its sedimentation coefficient is in the range of 4S and
      that it exists in a single- and double-stranded conformation. Moreover, analysis
      by nitrocellulose chromatography and CsSO4 density sedimentation of the nascent
      DNA labeled with 3H-uridine revealed that it is covalently linked to short chains
      of RNA, indicating that in HeLa cells RNA primer is involved in DNA replication.

PMID- 1030705
TI  - The role of actin in the temperature-dependent gelation and contraction of
      extracts of Acanthamoeba.
AB  - The temperature-dependent assembly and the interaction of Acanthamoeba
      contractile proteins have been studied in a crude extract. A cold extract of
      soluble proteins from Acanthamoeba castellanii is prepared by homogenizing the
      cells in a sucrose-ATP-ethyleneglycol-bis-(beta-aminoethyl ether) N,N'
      tetraacetic acid buffer and centrifuging at 136,000 g for 1 h. When this
      supernate of soluble proteins is warmed to room temperature, it forms a solid
      gel. Upon standing at room temperature, the gel slowly contracts and squeezes out
      soluble components. The rates of gelation and contraction are both highly
      temperature dependent, with activation energies of about 20 kcal per mol. Gel
      formation is dependent upon the presence of ATP and Mg++. Low concentrations of
      Ca++ accelerate the contractile phase of this phenomenon. The major protein
      component of the gel is actin. It is associated with myosin, cofactor, a high
      molecular weight protein tentatively identfied as actin-binding protein, and
      several other unidentified proteins. Actin has been purified from these gels and
      was found to be capable of forming a solid gel when polymerized in the presence
      of ATP, MgCl3, and KCL. The rate of purified actin polymerication is very
      temperature dependent and is accelerated by the addition of fragments of muscle
      actin filaments. These data suggest that Acanthamoeba contractile proteins have a
      dual role in the cell; they may generate the forces for cellular movements and
      also act as cytoskeletal elements by controlling the consistency of the
      cytoplasm.

PMID- 1030706
TI  - Membrane flow during pinocytosis. A stereologic analysis.
AB  - HRP has been used as a cytochemical marker for a sterelogic analysis of pinocytic
      vesicles and secondary lysosomes in cultivated macrophages and L cells. Evidence
      is presented that the diaminobenzidine technique (a) detects all vaculoes
      containing encyme and (b) distinguishes between incoming pinocytic vesicles and
      those which have fused with pre-existing lysosomes to form secondary lososomes.
      The HRP reactive pinocytic vesicle spaces fills completely within 5 min after
      exposure to enzyme, while the secondary lysosome compartment is saturated in 45-
      60 min. The size distribution of sectioned (profile) vaculoe diameters was
      measured at equilibrium and converted to actual (spherical) dimensions using a
      technique modified from Dr. S. D. Wicksell. The most important findings in this
      study have to do with the rate at which pinocytosed fluid and surface membrane
      move into the cell and on their subsequent fate. Each minute macrophages form at
      least 125 pinocytic vesicles having a fractional vol of 0.43% of the cell's
      volume and a fractional area of 3.1% of the cell's surface area. The fractional
      volume and surface area flux rates for L cells were 0.05% and 0.8% per minute
      respectively. Macrophages and L cells thus interiorize the equivalent of their
      cell surface area every 33 and 125 min. During a 3-period, the size of the
      secondary lysosome compartment remains constant and represents 2.5% of the cell
      volume and 18% of the surface area. Each hour, therefore, the volume and surface
      area of incoming vesicles is 10 times greater than the dimensions of the
      secondary lysosomes in both macrophages and L cells. This implies a rapid
      reduction in vesicle size during the formation of the secondary lysosome and the
      egress of pinocytosed fluid from the vacuole and the cell. In addition, we
      postulate that membrane components of the vacuole are subsequently recycled back
      to the cell surface.

PMID- 1030707
TI  - Functional significance of the variations in the geometrical organization of
      tight junction networks.
AB  - Using freeze-fracture techniques, we have examined the morpholog of tight
      junction networks found along the length of the alimentary tract of Xenopus
      laevis before and after metamorphosis. We have developed the hypothesis, based on
      these observations, that the geometrical organization of the network determined
      by the stress-induced shape changes normally experienced by the cells linked by
      the network. Consistent with this theory, tight junctions can be classified into
      two distinct types of network organization which differ in their response normal
      and experimentally induced stress conditions: (a) loosely interconnected networks
      which can stretch or compress extensively under tension, thereby adapting to
      stress changes in the tissue; and (b) evenly cross-linked networks which retain
      their basic morphology under normal stress conditions. The absorptive cells of
      the large intestine as well as the mucous cells of the gastrointestine or stomach
      are sealed by the first, flexible type of tight junction. The second type of
      junctional organization, the evenly cross-connected network, is found between
      absorptive cells of the small intestine and ciliated cells of the esophagus, and
      reflects in its constant morphology the relative stability of the apical region
      of both of these cell types. Networks intermediate between these two types arise
      when a cell which would normally form a lossely interconnected network borders a
      cell which tends to form a more evenly cross-linked network, as is found in the
      esophagus where ciliated and goblet cells adjoin. Despite the change in the
      animal's diet during metamorphosis from herbivorous to carnivorous, the basic
      gemetrical organization of the networks associated with each tissue of the
      alimentary tract remains the same.

PMID- 1030708
TI  - Segmental differentiations of cell junctions in the vascular endothelium.
      Arteries and veins.
AB  - A systematic survey of endothelial junctions in elastic (aorta) and muscular
      (mesenteric) arteries and in medium (renal and mesenteric) and large (cava
      inferior) size veins has been carried out in the rat using freeze-cleaved
      preparations. The arterial endothelium is provided with a complex of occluding
      and communicating junctions (gap junctions) comparable to, though less elaborate
      than, that described in arterioles. The particles of the occluding junctions
      behave like "single unit" particles and have the tendency to remain on B faces
      upon membrane cleavage. In the venous endothelium the junctions take the form of
      long occluding junctions with few associated communicating junctions (maculae
      communicantes). As in arterial endothelium, the junctional particles appear
      preferentially on B faces in cleaved preparations. These structures, although
      continuous over long distances, are interrupted focally by areas in which the
      junctional elements are similar to those found in venules: the ridges and grooves
      are short, discontinuous, randomly distributed along the general line of cell
      contact, and often particle-free. In muscular arteries two unusual types of
      junctions are encountered. Both are disposed in loops over short distances along
      the perimeter of the cell. One type appears to be a strectched-out version of the
      usual combination of occluding and communcating junctions of the arterial
      endothelium (this type is also occasionally encountered in the venous
      endothelium). The other type is reminiscent of the septate junctions found in the
      epithelia of invertebrates but the apparent similarity remains to be checked by
      further work.

PMID- 1030709
TI  - Isolation and electrophoretic analysis of nucleoli, phenol-soluble nuclear
      proteins, and outer cyst walls from Acanthamoeba castellanii during encystation
      initiation.
AB  - A technique is described for isolating nuceoli from Acanthamoeba castellanii.
      Nuclei isolated by a modification of the technique of F. J. Chlapowski and R. N.
      Band (1971) are sonicated in a surcrose-Tris-MgSO4-KC1-Triton X-100 buffer and
      centrifuged on a linear sucrose gradient extending from 1.3 M to 1.5 M with a 2.6
      M cushion, at 41000 rpm for 90 min. The only apparent contaminants in the
      nucleolar preparation are outer cyst walls. A procedure is described for the
      isolation of chemically pure outer cyst walls, and a comparison of the proteins
      with the nucleolar preparation reveals that outer cyst walls represent negligible
      contaminants. The ultrastructure of these isolated nucleoli examined with
      transmission electron microscopy is found to be identical with that of nucleoli
      from whole cells, fixed in an identical manner. The 50 nucleolar proteins
      separated by SDS gel electrophoresis have been examined throughout the growth
      cycle of Acanthamoeba and into the strat of induced encystment, at which time 10
      protein bands disappear, 11 bands are observed to decrease, and 8 are seen to
      increase in concentration. Phenol-soluble proteins are extracted from the
      nucleolus which correspond to 29 of the 50 nucleolar proteins, with 17 of these
      proteins corresponding to nucleolar proteins that change at the onset of
      encystment. Thes nucleolar proteins are also compared with those of rat liver
      nucleoli by gel electrophoresis, resulting in the observation that extremely few
      protein homologies exist between the two. Numerous quantitative and qualitative
      changes in the gel pattern of phenol-soluble nuclear proteins during early and
      late log phase growth and the onset of stationary phase were also observed.

PMID- 1030711
TI  - Ectogalactosyltransferase studies in fibroblasts and concanavalin A-stimulated
      lymphocytes.
AB  - In this communication, we have demonstrated that hydrolysis of the nucleotide
      sugar can cause errors in the detection of an ectoglycosyltransferase. Spleen
      cell suspensions can incorporate radioactivity when incubated with labeled UDP
      galactose, but all the activity is due to decomposition of the nucleotide sugar
      and uptake of the free sugar. The fibroblast cell lines can incroporate
      carbohydrate directly from UDP-galactose. Several criteria are presented with can
      be used to demonstrate that a nucleotide sugar is the direct carbohydrate donor.

PMID- 1030710
TI  - Studies of excitable membranes. II. A comparison of specializations at
      neuromuscular junctions and nonjunctional sarcolemmas of mammalian fast and slow
      twitch muscle fibers.
AB  - Mammalian fast and slow twitch skeletal muscles are compared by freeze-fracture,
      thick and thin sectioning, and histochemical techniques using conventional and
      high voltage electron microscopy. Despite gross morphological differences in
      endplate structure visualized at relatively low magnifications in this sections,
      rat extensor digitorum longus (EDL) (fast twitch) and soleus (slow twitch) fibers
      cannot be distinguished on the basis of size, number, or distribution of
      molecular specializations of the pre- and postsynaptic junctional membranes
      exposed by freeze fracturing. Specializations in the cortex of the juxtaneuronal
      portions of the junctional folds are revealed by high voltage electron
      stereomicroscopy as a branching, ladder-like filamentous network associated with
      the putative acetylcholline receptor complexes. These filaments are considered to
      be involved in restricting the mobility of receptor proteins to the perineuronal
      aspects of the postynaptic membrane. Although the junctional membranes of both
      EDL and soleus appear similar, a differential specialization of the secondary
      synaptic cleft was noted. The extracellular matrix in the bottom of soleus clefts
      was observed as an ordered system of filamentous "combs," These filamentous
      arrays have not been detected in EDL junctions. Examination of the
      extrajunctional sarcolemmas of EDL and soleus reveal additional differences which
      may be correlated with variations in electrical and contractile properties. For
      example, particle aggregates termed "square arrays" previously described in the
      sarcolemmas of some fibers of the rat diaphragm were observed in large numbers in
      sarcolemmas of EDL fibers but were seldom encountered in soleus fibers. These
      gross compositional differences in the membranes are discussed in the light of
      functional differences between fiber types.

PMID- 1030712
TI  - The role of eye pathology in low vision evaluation.
AB  - The low vision patient's ultimate function and ability to profit from his
      rehabiliation are influenced by his eye disease. A discussion of low vision
      patient management uses as a basis the observation that greater success is
      evidenced when the low vision patient is treated in the context of his eye
      disease, visual acuity and his subsequent adjustment problems. The diagnosis,
      visual acuity and the visual field are explored as elements of a functional
      classification. The author classifies eye diseases according to the pattern of
      visual field loss: no loss of visual field; central or macular field loss;
      peripheral or perimacular field loss. Visual characteristics are then elaborated
      and case management is suggested in the context of each category.

PMID- 1030713
TI  - Training low vision patients.
AB  - The importance of training low vision-patients to use low vision aids is
      discussed. The team approach is emphasized and the advantages of the additional
      expertise considered. Specific procedures and techniques are are recommended to
      enhance the chances for success of the training program and it is concluded that
      training is an important aspect of follow-up care which should be made an
      intergral part of low vision care.

PMID- 1030714
TI  - Community resources--why should we use them.
AB  - Professionals working with low vision persons may find themselves in the
      situation where they are either the first or only contact known to their patient.
      Because one person is usually not able to fulfill the diverse needs of the
      visually impaired individual, he may find it necessary to refer patients to other
      sources. Knowledge of the role of other related professionals and their
      availability in the community may make the difference between a fragmetned
      receipt of services or a total approach to vision rehabilitation.

PMID- 1030715
TI  - Visual acuity and highway accidents.
AB  - An analysis of binocularly obtained visual acuity test scores of 13,786
      automobile drivers was made in terms of the number of accidents reported by each
      driver during a 12 month period. For each of eight different age categories the
      drivers were classified as having poor acuity if their scores were below the
      lower quartile, and as having good acuity if their scores were above the median.
      The percent of drivers with poor acuity who reported three or more accidents was
      approximately double the percent of drivers with good acuity who reported three
      or more accidents. The proportion with poor acuity who reported two accidents was
      approximately 50% greater than the proportion for those with good acuity. These
      differences were statistically significant and prevailed at all age levels above
      19 years. The differences in proportions reporting one accident and no accident
      for the poor and good acuity categories were not significant.

PMID- 1030716
TI  - The center of projection.
AB  - Our ability to manipulate ourselves and the objects which surround us in our
      object space depends upon reasonably precise localization of the perceived images
      of these objects in our visual space. To be functionally sensible, this premise
      suggests that a "center of projection" must be located somewhere on the subject's
      body. Two studies which were done in an effort to illuminate an earlier study in
      regard to the center of projection are reported. One study used an "optical gun"
      which forced the subject to "shoot" at a perceived target. A second study used a
      focused beam headlamp to indicate the perceived direction of a perceived target.
      The perceived direction of the targets was altered by changes in the
      accommodative stimulus. Since the subject was aware only of the perceived
      direction of the image and since, in addition, he could not see the results of
      his efforts to localize the target, the location of a fixed center of projection
      could not be demonstrated.

PMID- 1030717
TI  - What causes astigmatism?
AB  - Although spectacles were invented in the 13th century, methods of testing for
      astigmatism have been developed only within the past one hundred years. Even
      today, the etiological factors responsible for corneal astigmatism are not well
      understood. A mechanism which may account for the existence of corneal
      astigmatism is proposed, on the basis of data concerning changes in astigmatism
      with age, racial variations in astigmatism and changes in astigmatism due to the
      wearing of contact lenses.

PMID- 1030718
TI  - Effects of mydriatics and a miotic on ocular discomfort and pupil responses.
AB  - Mydriatics produced two different effects on the discomfort threshold following
      administration of the drugs depending upon whether the mydriasis was produced by
      paralysis of the sphincter muscle or by activation of the dilator. When the
      sphincter was paralyzed by tropicamide, the discomfort threshold was elevated
      during the period of time that the pupillary light reflex was significantly
      reduced to the flashing stimulus. Initially, phenylephrine-induced mydriasis had
      no effect on the discomfort threshold, but as the pupil responses returned to
      normal the threshold rapidly increased and then gradually returned to a pre-drug
      level. The return of the threshold back to normal seemed to parallel the decline
      of action of phenylphrine on the dilator muscle. Significant impairment of the
      light reflex by pilocarpine-produced miosis was also related to an increase of
      the discomfort threshold.

PMID- 1030719
TI  - Management of fifth metatarsal head lesions by biplane osteotomy.
AB  - We have been using monoplane and biplane wedge osteotomies in the management of
      fifth metatarsal head lesions and have revised the procedure presented by
      Sgarlato, Subotnick and Gerbert in that we have been utilizing distal diaphyseal
      dorsiflexory adductory wedge osteotomies as well as proximal diaphyseal
      dorsiflexory adductory wedge osteotomies. We feel that the neck wedge osteotomy
      offers the advantage of reduced postoperative diability and correction of
      pathology.

PMID- 1030720
TI  - A histologic analysis of plantar fibromatosis.
AB  - Space occupying lesions of the plantar aspect can be a most preplexing surgical
      problem. Investigation into the histopathology of one of these lesions is
      presented. An in-depth cellular analysis of primary structures related to
      abnormal findings is also presented.

PMID- 1030721
TI  - Melorheostosis.
AB  - Melorheostosis is a seemingly rare condition of unknown etiology. Although it
      affects bone primarily, it may also involve soft tissue. The lower extremities
      are most frequently affected, and joints may become stiff as a result of
      obstruction of joint motion by thickened cortical sclerosis. The disease is
      difficult to diagnose in the early stages before bone changes become evident, and
      it is easily misdiagnosed. Surgery may be required to prevent deformity or to
      restore normal function.

PMID- 1030722
TI  - Double osteotomies for structural correction of hallux abducto valgus.
AB  - The authors discuss their procedure for performing osteotomies for correction of
      hallux abducto valgus. Their technique involves the use of a paper template which
      aids in establishing normal values according to the functional position in which
      they desire to place the joint. They outline their procedure for performing the
      closing abductory wedges of the base of the first metatarsal and the closing
      medial wedges of the head of the first metatarsal. After the correction has been
      completed, they apply a below-the-knee cast.

PMID- 1030723
TI  - A.C.F.S. Neoplasm survey of the foot--1975: A continuing study.
AB  - This continuing investigation, now in its third year, is being conducted to
      record statistics on tumors that affect the foot. The study was undertaken to
      increase the diagnostic information on the various types of tumors in order to
      assist the pediatric surgeon in the differential diagnosis and surgical
      management of tumors of the foot. The study is very important to the profession,
      and it is important for all foot surgeons to participate.

PMID- 1030724
TI  - Sinus tarsi pain: case history.
AB  - An attempt was made to give the podiatrist some insight into the differential
      diagnosis of sinus tarsi pain. One possible etiology is discussed in detail along
      with case presentation and treatment.

PMID- 1030725
TI  - Reduction of comminuted metatarsal fractures utilizing circular wire fixation.
AB  - The comminuted fracture of a metatarsal shaft provides a greater challenge to
      clinicians in relationship to stabilization and and fixation then does the simple
      noncomminuted type of fracture. Comminuted fractures may result in gross
      displacement or fragmentation of the bony segments calling for more dramatic
      methods of fixation to insure proper union with optimal bone healing and minimal
      postfrature complications. Adequate approximation of fractured bone segments is
      essential to insure proper restoration of function and stability to fractured
      bones. Open reduction with circular wire fixation is one method by which proper
      approximation of comminuted fracture bone segments can be accomplished.

PMID- 1030726
TI  - Occlusive arterial disease in the lower leg and foot.
AB  - In approaching a patient suspected of peripheral vascular disease the following
      signs and symptoms are of key importance (16): 1) Pain in the extremity which is
      induced by exercise and relieved by rest; pain which is influenced by posture is
      localized to one digit, is unilateral or is paroxysmal. 2) Impaired pulsations of
      peripheral arteries. 3) Abnormal color of the skin, particularly when affected by
      raising or lowering the part. 4) Gangrene, ulceration, impaired nail and hair
      growth, excessive calluses, or paronychial infections. 5) Unusual warmth or
      coldness. 7) Swelling, atrophy, or difference in length of extremity. 8)
      Ausculatory evidence of arteriovenous fistula. 9) Cyanosis or unusual pallor of
      digits when immersed in cold water. 10) Peripheral neuritis.

PMID- 1030727
TI  - Capsule reconstruction.
AB  - In this article, the author discusses the general concept of of capsule
      reconstruction and emphasizes the importance of discriminative judgement in in
      capsule reconstruction. He reviews capsular composition and histology, as well as
      varied capsulotomy procedures.

PMID- 1030728
TI  - Osteomyelitis associated with peripheral vascular disease secondary to diabetes
      mellitus.
AB  - Diabetes mellitus and arteriosclerotic vascular disease have been found to be the
      predisposing factors of osteomyelitis associated with peripheral vascular disease
      (10). A diabetic person is more susceptible to osteomyelitis because of the
      microangiopathy, peripheral neuropathy and decreased resistance to infection. In
      diabetes mellitus there can be microangiopathy which results from the
      proliferation of the endothelium of the intima and thickening of the basement
      membrane. This further contributes to a sluggish blood flow. In the patient with
      arteriosclerotic vascular disease, the lumens of the arterioles and arterioles
      are compromised by the atheromatous plaques. The anatomic structure of the blood
      supply to bone along with the pathologic membrane thickening, allows for slowing
      of blood. This slowing of blood flow causes micro-thrombi and enhances bacterial
      growth. In diabetes mellitus it has been shown that there is a decreased
      immunologic response which, along with the above, contributes to the sheltering
      and proliferation of bacteria in the small bones of the foot.

PMID- 1030729
TI  - Pattern-analytic approach to analysis of accidents due to human error: an
      application of the ortho-oblique-type binary data decomposition.
AB  - An ortho-oblique-type binary data decomposition based on data matrices providing
      relevant conditions of accidents is proposed as a means of classifying patterns
      of human error, and the computing procedures are described. The usefulness of the
      technique is shown by a numerical example of accidents in freight-car
      classification yard work. Forty-two severely injured victims were interviewed by
      psychologists and the contents of case reports were rearranged into a reliable
      binary data matrix which indicated the presence or absence of an
      interrelationship between each sample and each of 42 items of operational,
      environmental, and psychological conditions. Three patterns of error leading to
      an accident were identified by interpreting the orthogonally rotated results.
      They were 1) failure of strenuous performance in relation to fatigue and poor
      communication, 2) veterans' mistakes in teamwork, possibly due to hasty operation
      or distractions, and 3) errors caused by certain defects of machines or
      inappropriate work space. Recommendations were thus made on training plans for
      beginners. The importance of using non-scaled accidental data in binary form and
      allowing rotation for data decomposition is discussed.

PMID- 1030730
TI  - Factors affecting choice of mode of sitting and sleeping by inhabitants of public
      housing.
AB  - Field research on mode of living was undertaken in the winter of 1962 and 1973 in
      households in public residences owned by the Japan Housing Corporation. Factors
      affecting mode of sitting and sleeping were analyzed for 63 households replying
      to questionnaires in both years. Three modes, the floor, chair-beds, and their
      combined use were classified for three major living activities of meal-taking,
      relaxing, and sleeping. Rate of households with the chair-bed mode was the
      highest for meal-taking and the lowest for sleeping. Choice of the chair-bed mode
      was associated with young household heads, smaller family size, separation of
      sleeping rooms from dining space by a wooden floor, and possession of furniture
      for relaxing and fixed beds. The adoption of the floor mode was common to
      households with only elderly people who, in spite of ample space, preferred it
      and those with small children. The floor mode was also frequent in houses without
      dining-kitchen areas where meals and sleeping were usually done in the same room.
      The combined mode was found for all of the three living activities. The results
      confirm that each pattern of floor utilization was closely related not only with
      resident factors but also with limited living space and the family's own way of
      living.

PMID- 1030731
TI  - Spontaneous alternation of the working arm in one-arm cranking.
AB  - One-arm cranking was done by ten healthy male adults at an oxygen intake level of
      about 1.0 liter/min. Each subject performed two kinds of cranking at a speed of
      60 rpm: forced cranking using only one arm continuously for 15 min and free
      cranking for 30 min with the instructions to alternate from one arm to the other
      whenever fatigue set in. The results, excluding those of a subject who changed
      arms very frequently, were analyzed. In forced cranking, oxygen intake and heart
      rate steadily increased, the average time of appearance of local fatigue being
      161 sec for the stronger arm and 122 sec for the weaker one. In free cranking,
      the working arm was changed 6 to 23 times during the 30-minute period, while
      oxygen intake and heart rate increased with fluctuations. The mean duration
      interval was 175 sec with the stronger arm and 123 sec with the weaker one. The
      mean interval of arm alternation was positively correlated with the individual
      time of onset of the sensation of local rigidness during forced cranking, but not
      with the individual time of initiation of respiratory distress. It is suggested
      that alternation of active muscles in moderately dynamic work may be linked with
      an early stage of local fatigue which is different from that of static work.

PMID- 1030732
TI  - An electromyographic study on training to pronounce English consonants unfamilar
      to Japanese.
AB  - This paper is concerned with the electromyographic analyses of the pronunciation
      of English consonants as pronounced by a native speaker, a well-trained Japanese,
      and an untrained Japanese. Six muscles related to movement of the lips and the
      mandible were tested. The three-paired English words (right--light, she--see, and
      thank--sank) were selected, as they include consonants that are very difficult
      for Japanese to pronounce or distinguish correctly when heard. Electromyographic
      results obtained for the native speaker and the well-trained Japanese indicated
      light pouting of the lips during the preparatory period for pronouncing [r],
      raising of the upper lip from the preparatory period in the pronouncing of [sh]
      and [th], and a downward spreading of the lower lip from the preparatory period
      in the pronouncing of [l] and [s]. The untrained Japanese subject was given
      individual and intensive training for several hours with a technique based on
      electromyographic observation results. Following this, the subject showed
      improvement in pronouncing the consonants, with the exception of [sh] which the
      subject had learned to pronounce at a language school. The electromyograms of the
      subject approached those of the native speaker and the well-trained Japanese.

PMID- 1030733
TI  - Combined influences of ambient temperature and graded work on cardiopulmonary
      functions.
AB  - Several cardiopulmonary items were measured in eight adult females who had
      performed stationary ergometer cycling of 75-450 kgm/min in air temperature
      between 14 degrees and 35 degreesC. The experiments were designed on the basis of
      the Latin square method and the results were analyzed by computing the analysis
      of variance and multiple regression equations for each item linked with work rate
      and air temperature. In view of the degree of affinity of the effect of work rate
      and that of air temperature, the items could be divided into three groups. The
      first group consisted of items of pulmonary functions closely related with work
      rate but independent of air temperature, such as pulmonary ventilation, oxygen
      intake, carbon dioxide production, respiratory exchange ratio, and ratio of
      oxygen removal. The second group characterized by linear dependency on air
      temperature included mean skin temperature and mean innermost air temperature.
      The third group consisting of heart rate, pulse sum during work, and work pulse
      sum was intermediate. In spite of the confusion in the literature about the
      attitude of oxygen intake or mean skin temperature during work in heat, the
      former was the most stable in relation to change in air temperature and the
      latter was independent of work intensity.

PMID- 1030734
TI  - Cardiorespiratory mobilization and endurance performance.
AB  - Twenty subjects performed for 11 min on a bicycle ergometer 30 sec following 5
      min of prior exercise (PE) at each of four different intensities. PE was adjusted
      to maintain a heart rate of 110, 140, and 170 beats/min. The 4th treatment was no
      PE. Heart rate was an estimate of the mobilization of the cardiorespiratory
      system during exercise. The criterion task (CT) included cycling for 10 min
      against 3 kg resistance at 68 rpm followed by 1 min of an all-out work bout where
      subjects tried to complete as many rpm's as possible against 3 kg. The 11th
      minute was used to assure the complete exhaustion of energy reserves following
      the paced part of the task. Overall performance following PE-170 was
      significantly worse than that following no PE, PE-110, and PE-140, which was
      probably due to a build up of anaerobic metabolites such as lactate during the
      PE. Total work appeared to be greatest following PE-110, which showed a slight
      tendency toward better performance especially after the 6th minute. However, no
      clear cut evidence was produced to support the hypothesis that light to moderate
      PE would sufficiently improve performance by mobilizing the cardiorespiratory
      system, thereby reducing the initial oxygen deficit in the CT and thus allowing
      more work to be performed.

PMID- 1030735
TI  - Influence of castration and testosterone on pineal multi-unit activity in quail.
AB  - Pineal multiple unit electrical activity was recorded in unanaesthetized quail
      maintained under a short or long daily photoperiod. Both spontaneous and flash
      induced multiple unit firing were recorded in intact, castrated or superior
      cervical ganglionectomized birds. The effects of testosterone administration were
      tested in each experimental group. 10 Whereas orchidectomy led to a substantial
      rise in pineal multi-unit activity (MUA), testosterone propionate injection
      resulted in a markedly decreased MUA in castrates. A smaller decrease in MUA was
      caused by androgen treatment in intact or ganglionectomized birds. Androgen
      treatment of controls and ganglionectomized quail was not so effective in
      reducing pineal activity as was lengthening the photoperiod from 6L-18D to 18L
      6D. 20 Repetitive photic stimulations resulted in a significant suppression of
      pineal MUA in all intact, castrated and ganglionectomized quail, whether or not
      testosterone was administered.

PMID- 1030736
TI  - [Diet influence on growth-characteristics of the shrimp Crangon Crangon L.,
      estimated by the evolution of nucleic acid content (author's transl)].
AB  - 1. Young sand-shrimps having an initial weight of 63 mg were reared for 4 months
      with a natural diet (A) and a compounded diet (B). 2. Growth is studied, both by
      the evolution of the fresh weight and the variation of cell-number and cell-size;
      these are estimated from total DNA and fresh-weight/DNA ratio evolution. 3. With
      diet A, the mean weight increment is a linear function of time, the daily weight
      gain being equal to 2.8 mg/day. The increase in total DNA content per shrimp is a
      linear function of fresh weight; its value goes up from 187 to 1020 micromoles.
      The fresh-weight/DNA ratio, initially equal to 337.9 (mg/micromoles) ,remains
      constant. For the whole experiment, growth is only a result of cellular
      multiplication. 4. With diet B, the weight gain is inferior to that observed with
      diet A. The fresh weight gain curves show two visibly homogenous steps, each with
      a distinct growth-rate; the mean daily weight gain is equal to 1.7 mg/day during
      the first two months, and equal to 2.6 mg/day for the two following months (fig.
      1). In reality, from the total DNA and fresh-weight/DNA ratio evolution, 3
      successive steps can be discerned (fig. 2, fig. 3). During the first month, total
      DNA increases from 187 to 418 micromoles and fresh-weight/DNA ratio falls down to
      273.9, a-19% decrease. For this period, growth is only the result of cellular
      multiplication, and the decrease of the weight-gain in comparison with diet A is
      attributed to a decrease in cellular size. During the second month, as the fresh
      weight increases from 114.5 to 161.2 mg, total DNA increases from 418 to 519
      micromoles and the fresh-weight/DNA ratio returns to its initial value. Two
      thirds of the growth is the result of cellular multiplication, and the rest being
      due to cell-size enlarging. For the last two months, as the mean fresh weight
      increases from 161.2 to 296.7 mg, the DNA per shrimp, hence the cell-number,
      remains constant; but the fresh weight/DNA ratio, or the cell-size, is multiplied
      by 1.93. 5. By the method used for this study, it is possible to evidence
      influence of diet on the growth mechanisms themselves (cellular multiplication
      and cell enlarging). 6. The influence of diet on the growth of the shrimp could
      be explained by, either a diet qualitative deficiency, or a food-intake decrease.
      The possibility of a hormonal control has been suggested.

PMID- 1030737
TI  - Carotid sinus, aortic and subclavian baroreceptor activities during
      cardiopulmonary bypass in rabbits.
AB  - 10Carotid sinus (SIN), aortic (AO) and subclavian (SUB) baroreceptor activities
      were recorded from intact nerves during experiments using cardiopulmonary bypass
      in 11 rabbits. These activities (number of impulses/second) were expressed as a
      percentage of basal activity observed before artificial circulation (AC). The
      preparation remained in a relative, "stable period" for up to 45 minutes. Then, a
      progressive decrease occurred in maximal arterial pressure (AP max) in the 11
      experiments (fig. 2,4). 20 According to the level of arterial pressure the
      "stable period", our experiments can be divided into two groups: a) Group I (6
      rabbits) with AP max greater than or equal 90 mm Hg; in this group, the
      correlation coefficients between pressure levels and nervous activities
      calculated during the period 0-70 min after the onset of AC, were positive (fig.
      3) and statistically significant, as we could expect (AO, p less than 0.02; SIN,
      p less than 0.01; SUB, p less than 0.01). b) Group II (5 rabbits) with AP max
      less than 90 mm Hg; surprisingly, in this group no positive correlation was found
      between levels and nervous activities, which were generally very high (fig. 5).
      30 Experiments were performed in 18 other rabbits in order to check the nature of
      the higher activities recorded in group II. These high activities were not of
      chemoreceptor or efferent origin, and, thus, were thought to be indeed really
      from baroreceptive fibres. 40 Ten experiments under AC were carried out to test
      the reactivity of baroreceptors in response to induced increase and decrease of
      pressure. The responses were qualitatively normal (i.e. an increase of pressure
      produced an increase in the nervous discharge), but in group II, the operative
      point was set at a higher level (fig. 6). 50 A possible, time-dependent, shift in
      the baroreceptor response curve under AC can account for these findings by
      giving, in some cases the illusion of a negative correlation between baroreceptor
      activity and arterial pressure (fig. 8). 60 The above mentioned shift in the
      baroreceptor response curve could be related to a change in sympathetic control
      of baroreceptors,resulting in a higher activity, and initiating and/or
      maintaining hypotension.

PMID- 1030738
TI  - [Connections between inspiratory medullary neurons and phrenic or intercostal
      motoneurones (author's transl)].
AB  - 10 The activity of 107 medullary inspiratory neurones has been recorded
      extracellularly in anesthetized cats (urethane-chloralose). According to their
      localization in the medulla and to their axonal pathways (tested by antidromic
      activation), these neurones were classified as: bulbo-spinal neurones (NBSI)
      which send their axons to the spinal cord; they are located in the dorsal or the
      ventral respiratory nucleus; propriobulbar neurons (NPBI) whose axons are
      probably entirely located within the medulla; they are found only in the ventral
      nucleus. 20 Summation of gross discharges from phrenic (C5 ventral root) or
      inspiratory intercostal (from T4 to T10) nerves was triggered by spikes from
      medullary respiratory neurones. If the studied neurone controls the activity of
      the recorded motor fibres, after sommation of a great number of sweeps (3,000 to
      5,000), the summed nerve activity displays a short delay excitatory wave,
      indicating that the activity of the motoneurones is increased after the onset of
      the medullary potential. On the other hand, there is a flat summed nerve activity
      if the nerve discharge is not directly dependent on the medullary recorded
      activity. 30 The dorsal nucleus NBSIs send their axon to the contralateral
      phrenic motoneurones (as it is revealed by the excitatory wave noted on the
      summed phrenic nerve activity, fig. 1 and 4) and not to the intercostal
      motoneurones (fig. 4). 40 The ventral nucleus NBSIs control contralateral
      intercostal motoneurones (fig. 5). Some of them send their axons only to these
      motoneurones, but the majority also act on phrenic motoneurones (fig. 2 and 5).
      50 Connections between NBSIs and phrenic motoneurones are monosynaptic and
      probably also those between NBSIs and intercostal motoneurones. 60 No excitatory
      wave has been observed on phrenic or intercostal summed activity when summation
      was triggered by NPBI spikes (fig. 3). This confirms the accuracy of the
      "antidromic stimulation test" used to classify medullary respiratory neurons.

PMID- 1030739
TI  - Thoughts on love, sex, and commitment.
AB  - The effort is made to delineate some of the key issues involved in the
      interaction of love, sex, and commitment. Coupling is viewed from an ethological
      perspective that suggests that, in addition to the developmental contribution of
      the parent-child experience, peer-peer relating is a major determinant of adult
      hetrosexual relatedness. Couples are next considered as responding to social and
      economic forces that influence powerfully what types and duration of
      relationships have survival value. Finally, the nature of the inner experience of
      couples, their existential awareness of themselves and the other, and the meaning
      that they attribute to it is discussed. Being a member of a couple is
      participating in a story, sometimes a "love story," and whether or not it is seen
      as a good story depends on one's critical vantage point. Finally, the analysis of
      relationships is contrasted with the experience of a relationship as a gestalt, a
      whole; not as the sum of its parts.

PMID- 1030740
TI  - Anger, sexuality, and the growth of the ego.
AB  - This paper examines the long-term issues of sexual dysfunction in terms of normal
      psychosexual development. Human sexual development and ego growth take
      simultaneous origin within the symbiotic relationship of the child and its first
      nurturant caretaker, usually the mother. Infantile sexuality, the pleasure of the
      total body, is equivalent to love and dependent upon sameness and continuity,
      tending toward fusion. Adult sexuality depends for its emotional impetus upon
      separateness and difference between lovers. Once established, adult sexual
      relationships drift inexorably toward the symbiotic unity implicit in loving.
      Genital sexuality may be sacrificed in the preference for more global
      satisfactions reminiscent of the infantile sexual experience. Essential to the
      adult sexual relationship then is the capacity to bear and express conflict and
      anger as a means of breaking the symbiotic tie; a continuous restructuring of ego
      boundaries is necessary for the maintenance of a functioning sexual relationship
      of long duration.

PMID- 1030741
TI  - Guidelines for evaluating sex therapy.
AB  - Clinical advances in the treatment of human sexual dysfunctions must be
      documented by objective and scientific assessments of changes in patients as a
      result of the therapy. The principle guidelines for evaluating such changes
      include (1) the use of standard methods of interviewing patients and recording
      information obtained, both before and after treatment, (2) careful specification
      of treatment technique(s) used, standardized when applied to any group of
      patients, (3) assessment of patients' psychosocial as well as sexual functioning,
      (4) clearly defined criteria for diagnosis and outcome, (5) use of control or
      comparison groups, and (6) methodical in-person follow-up contacts. The
      procedures can be applied by clinicians in their individual practice as well as
      by independent evaluation programs. These guidelines, presented in this paper,
      provide a framework for reliable investigations to determine which treatments
      work best for which patients with which sexual dysfunctions.

PMID- 1030742
TI  - Central auditory dysfunction.
AB  - The numerous tests applicable to the assessment of central deafness are briefly
      reviewed. It is likely that the more specific verbal and non-verbal tests, which
      assess more complex auditory function, will prove to be most useful in the
      assessment of these problems. We believe that the concept of a spectrum of
      clinical-anatomical types of central deafness is useful, namely, cortical,
      brainstem and more peripheral forms; a detailed study of an example of a
      predominantly brainstem type of central deafness is presented. An
      interdisciplinary approach which applies the methods of the audiologist,
      otolaryngologist, and neurologist to these patients is required to localize the
      site of the lesion, to detect and describe the deafness and to establish its
      etiology.

PMID- 1030743
TI  - Experiments on the mechanism of Meniere attacks.
AB  - The pattern of response decline following semicircular canal stimulation
      corresponds to a mechanical process. This process is the elastic recoil of the
      hairs of the sensory cells. The response decline is the same, whether the
      endolymph-cupula system is patent or mechanically maintained in a displaced
      position. The role of the bending of the entire cupula as the principle factor is
      excluded for the response and its decline. Repeated endolymph displacements
      immediately after each decline of response always result in an equal response and
      its decline. This rules out the depletion of a chemical mediator as a cause for
      the response decline. Indentations of the sidewalks of the ampulla result in
      reactions suggesting that the ampulla is filled with a loose gel secreted by the
      planum semilunatum cells.

PMID- 1030744
TI  - British Columbia ear bank.
AB  - The B.C. Ear Bank was established in 1974 as a temporal bone laboratory devoted
      to the study of hearing loss and histological examination of temporal bones. It
      expanded its activities to the collection and preservation of homograft otologic
      tissue needed for the ever expanding field of ear surgery. The function of the
      ear bank in these two fields is discussed in detail.

PMID- 1030745
TI  - Evoked potential audiometry.
AB  - A large number of different components of the auditory evoked potential can be
      recorded from the human scalp using averaging techniques. It is now possible to
      evaluate with such evoked potential measurements the functioning of the entire
      human auditory system from the hair cell receptors to the association areas of
      cortex. This multiplicity of evoked potential components is important clinically
      since any one component measurement may be the most appropriate for a certain
      subject at a certain time, and also because the replication of objective
      audiological findings using more than one testing method allows greater
      confidence in the results. As well as providing an accurate means of determining
      the extent of a hearing loss, evoked potential studies can also provide
      information concerning the type and location of such a defect.

PMID- 1030746
TI  - Killing effect of normal peritoneal exudate cells in guinea pigs on microfilariae
      of Dirofilaria immitis evoked by passive transfer of immune humoral factor.
AB  - Parasiticidal activity of normal peritoneal exudate cells on microfilariae of
      Dirofilaria immitis in diffusion chambers implanted into normal guinea pigs was
      evoked by intraperitoneal passive transfer of anti-D. immitis serum. The immune
      serum was fractionated into supernatant and sediment by ammonium sulfate
      precipitation. The parasiticidal effect was reproduced with the supernatant and,
      to a less extent, with the sediment. Anti-D. immitis serum from the animals
      sensitized 5 days before was also effective in this respect. From these results
      it can be concluded that the factor responsible for the phenomenon is some other
      factor(s) than the antibody. In addition, the in vitro cytotoxicity test
      demonstrated an enhanced Mf-killing activity of sensitized peritoneal exudate
      cells by adding with anti-D. immitis serum.

PMID- 1030747
TI  - Comparison of frequency characteristics of photopic and scotopic S-potentials in
      the carp.
AB  - Frequency characteristics of photopic and scotopic L-type S-potentials were
      studied in the carp retina, using either an impulse or a sinusoidal light input
      superimposed on a steady background light of various intensities. The photopic
      type responses were faster than the scotopic responses if their frequency
      characteristics were compared without background illumination. However, the
      difference was not absolute. Both types of responses became faster in the
      presence of background illumination. The stronger the background, the faster was
      the response. At relatively high background intensities, the response to a flash
      became diphasic due to the rebound effect which corresponds to a low frequency
      attenuation in the gain characteristics. The main difference between the two
      types of responses was found in the phase relation; the scotopic units showed
      more phase lag indicating an extra delay even under a condition in which the time
      course of their response was faster than that of the photopic units.

PMID- 1030748
TI  - Maximum capacity of ventilation and efficiency of gas exchange during liquid
      breathing in guinea pigs.
AB  - Mechanical characteristics of liquid breathing were studied in isolated lungs of
      guinea pigs filled with fluorocarbons FC-75 and 77. It was found that compliance
      increased to 2-2.5 times, resistance increased to 20 times, and maximum
      expiratory flow decreased to 1/20-1/25 times the corresponding values observed in
      air-filled lungs. The maximum volume of ventilation during liquid breathing was
      then predicted to be 50 ml/min from parameters mentioned above, and about 80% of
      such ventilation was actually observed in anesthetized animals. Measurements on
      O2-uptake and CO2-output as well as gas analysis of arterial blood showed that
      the ventilation volume was insufficient to maintain the normal gas exchange in
      the animal unless body temperature was lowered. An increase in physiological dead
      space observed during liquid breathing suggested that slow diffusion rate of
      gases through the liquid was responsible for the deficiency of the gas exchange.

PMID- 1030749
TI  - Mechanisms underlying cessation of rabbit sinoatrial node pacemaker activity in
      high potassium solutions.
AB  - To determine the effect of high extracellular potassium concentration ([K]o) on
      the membrane current of the sinoatrial node cell, voltage clamp experiments were
      conducted using the double microelectrode technique. When depolarizing clamp
      pulses were applied, a transient inward current was followed by an outward
      current and an outward current tail flowed after the pulse. The amplitude of both
      the transient inward current and the outward current tail were markedly reduced
      with increasing [K]o, but the magnitude of the outward current during
      depolarization scarcely changed. The inward current during hyperpolarizing clamp
      pulses increased in magnitude at higher [K]o and the reversal potential for the
      inward current change decreased with increasing [K]o. From these results it was
      concluded that the suppression of the sinoatrial node automaticity at higher [K]o
      was due to the decrease in magnitude of both the transient inward current and the
      outward current tail. As the cause of the depression of the transient inward
      current, its inactivation through depolarization, increased outward leak current
      and some direct inhibitory effect of K were proposed. The reduction of the
      outward current tail was attributed to the decrease in the driving force of the K
      current.

PMID- 1030750
TI  - Prostaglandin action on the main pulmonary artery and portal vein of the rabbit.
AB  - The effects of prostaglandins on electrical and mechanical properties of the
      rabbit pulmonary artery and portal vein were investigated and compared with those
      recorded from the guinea pig. In the pulmonary artery, PGE1 and PGE2 (10(-9)-10(
      6) g/ml) had no effect on mechanical properties, but PGF2alpha (10(-8) g/ml)
      produced tonic contraction, while in the portal vein, PGE1 and PGE2 caused
      relaxation of the tissues. When the tissue of the pulmonary artery contracted
      from pretreatment with noradrenaline (10(-7) g/ml), PGE1 and PGE2 experienced
      partial, incomplete, relaxation, while PGF2alpha enhanced the mechanical response
      produced by noradrenaline. At concentrations of 10(-7) g/ml, PGE1 and PGE2
      hyperpolarized the membranes in both smooth muscle tissues while PGF2alpha
      depolarized them. These agents decreased membrane resistance at all membrane
      potential levels to values below those measured in Krebs solution. PGF2alpha (10(
      6) g/ml) applied simultaneously with procaine (1.4-2.7 x 10(-3) g/ml) markedly
      enhanced the mechanical responses of both tissues beyond the effects evoked by
      PGF2alpha alone. However, noradrenaline (10(-8) and 10(-7) g/ml) applied
      simultaneously with procaine (1.4 x 10(-3) g/ml) markedly suppressed the
      mechanical responses evoked by noradrenaline alone. It is concluded that PGE1 and
      PGE2 brought about relaxation of both tissues (vasodilation), while PGF2alpha
      brought about contraction (vasoconstriction). The excitatory action of PGF2alpha
      (10(-5) g/ml) and noradrenaline (10(-7) g/ml) on the electrical and mechanical
      responses appear as the same phenomena, i.e., depolarized membrane, decreased
      membrane resistance and contraction, although the mechanisms producing the above
      phenomena differ.

PMID- 1030751
TI  - [Kidney function after reconstructive operations on the renal arteries in
      renovascular hypertension].
AB  - A total of 117 patients with renovascular hypertension operated upon by employing
      reconstructive surgery upon renal arteries for producing hypotensive effect and
      restoration of renal functions were examined. Examination was made before
      surgery, in the near (up to 6 months) and remote post-operative periods (after a
      lapse of up to 10 years time). Soon after the operation persistent normalization
      of the arterial pressure was recorded in 78 (67 per cent) of 117 patients,
      improvement supervened in 12 per cent of the cases, and a positive hypotensive
      effect could be achieved in 92 or 79 per cent of the patients. The immediate
      normalization and improvement in the evolution of arterial hypertension continue,
      as a rule, also late after surgery. Following reconstructive operations on the
      renal arteries with normalized arterial pressure or its improvement the great
      majority of the patients demonstrated re-establishment or a significant
      improvement of both the summary (filtration, concentration and even nitrogen
      excretory) and individual renal functions (as shown by the results of
      radioisotope renography with I131 hippuranium and excretory urography. In
      patients with malignant course of arterial hypertension successful reconstructive
      surgery was followed by a tendency toward retrograde development of the arterial
      hypertension malignancy.

PMID- 1030752
TI  - [Characteristics of energy metabolism in different regions of the heart, liver
      and kidneys in myocardial infarct after administration of prednisolone].
AB  - The effect of therapeutic doses of Prednisolone (1 mg/kg) on the indices of
      energy metabolism in different regions of the heart, liver and kidneys was
      studied in 70 dogs within the initial 10 days after the ligation of the left
      coronary artery. The administration of such doses of Prednisolone was found to
      increase the respiration of the mytochondria and especially the binding of the
      inorganic phosphate in the zone of the infarction, to switch over from the poorly
      effective oxidation in the nondamaged area of the left ventricle to the one
      firmly conjugated with phosphorylation, to level the balance between the
      respiration and phosphorylation of the mytochondria in the right ventricle, liver
      and kidneys. The beneficial effect of Prednisolone upon the energy metabolism in
      the tissues during myocardial infarction manifested itself in growing depots of
      ATP and creatinephosphate in all regions of the heart. This effect of
      Prednisolone is most clearly expressed during the initial 5 days of its
      administration, and is less demonstrative when given for 10 days.

PMID- 1030753
TI  - [Cerebral hemodynamics in neurocirculatory hypotension].
AB  - Data are presented on the state of cerebral haemodynamics in patients with neuro
      circulatory hypotension that was studied by measuring the arterial pressure in
      various zones of blood supply (the central retinal artery, superficial temporal
      artery and the brachial artery), by studying the ocular fundus and by
      rheoencephalography. The cerebral haemodynamic disorders were revealed in the
      form of regional cerebral hypertension in 13.4% and regional cerebral hypotension
      in 29.4%, against the background of a general fall of the arterial pressure. In
      regional cerebral hypertension the vessels of the ocular fundus were narrowed, in
      regional cerebral hypotension--vice versa. The reduction of the pulse pressure
      during neuro-circulatory hypotension also attracts attention, and it can be
      considered a sign of impaired blood supply to the brain.

PMID- 1030754
TI  - [Comparison of the electrocardiographic, clinical and coronarographic data in
      ischemic heart disease after physical exertion].
AB  - A comparison of the clinical data and those of ECG under physical exercises with
      the results of coronary angiography is presented for 130 patients with the
      ischaemic heart disease, aged 28 to 68 years; 63 of them had survived myocardial
      infarction, 63 had angina of effort, 65--angina at rest and angina of effort, 2
      presented no complaints. The comparison of the clinical and coronarographic data
      demonstrated a high correlation in cases of angina; in 85.3% of the patients with
      typical angina pectoris coronary angiography revealed anatomic changes in the
      coronaries. Having compared the data to the positive exercise test with the
      results of coronary angiography, the authors found that 87.9% of the examined
      patients have--with a positive exercise test--coronary lesions and the S--T
      segment depression during physicial exercises 1 mm below the iso-electric line,
      which permits to diagnose anatomic changes in the coronaries. According to the
      authors, an acute onset of the disease, a brief history (up to 1 year) and a
      prompt restoration of the ECG following physical exercises are typical rather for
      local lesions of one coronary branch.

PMID- 1030755
TI  - [Circulation time of 125I-labeled fibrinogen in patients with ischemic heart
      disease with different types of hyperlipoproteinemia].
AB  - In 31 patients with ischaemic heart disease and different types of
      hyperlipoproteinemia the Takeda method was used for determining the duration of
      125I-labelled fibrinogen circulation. The half-life period of labelled fibrinogen
      was found to be twice shorter in the patients than in the normal individuals. Two
      types of curves of plasma radioactivity reduction were distinguished in patients
      with ischaemic heart disease. The briefest circulataion period of the labelled
      fibrinogen was found in patients with type II hyperlioproteinemia. In patients
      with ischaemic heart disease and normal blood lipids content the period of
      circulation of the labelled fibrinogen comprised 2.07 +/- 0.27 days and was
      higher than in those with hyperlipoproteinemia.

PMID- 1030756
TI  - [Rheologic properties of blood in patients with complicated and uncomplicated
      course of acute myocardial infarct].
AB  - The examination was conducted in 77 patients with a varying course of acute
      myocardial infarction, in 10 normal individuals, 10 patients with angina
      pectoris, and 20 patients with post-infarction cardiosclerosis. The patients with
      acute myocardial infarction demonstrated a higher, than in the control group,
      blood viscosity, fibrinogen, hematocrit level and erythrocytes aggregation rate.
      The most significant changes in the rheologic properties of blood were observed
      in the cases of complicated myocardial infarction. Patients with severe coronary
      shock displayed both high and low levels of blood viscosity, fibrinogen and
      hematocrit, which may be due to the different stages of the coronary shock.

PMID- 1030757
TI  - [Dynamics of bundle-branch block in the acute period of myocardial infarct].
AB  - On the basis of a randomized analysis of ECG of 200 patients in the acute phase
      of myocardial infarction the relative incidence of partial blocks was
      demonstrated: 33% among the survivors, and 54% among the hospital mortality
      cases. The prognostic value of the development of blocks was supported by the
      fact that it corresponded to further aggravation of the clinical course-
      increased cardiac pains, manifestations of cardiac insufficiency, development of
      arrhythmias. The bundle of His branch block may mask the infarction changes of
      ECG. Signs of incomplete blocking were revealed that include a leftward deviation
      of the axis, increase of R-wave amplitude in the 1 and aVL leads, appearance of
      enhancement of the S-wave in the II and V5-6 leads that preceed a complete
      blocking of the appropriate branch. The obtained data indicate the necessity of
      tracing the intraventricular conduction in the course of ECG monitoring during
      the acute period of myocardial infarction.

PMID- 1030758
TI  - [Hemodynamic research and physiopathologic remarks on "vibration angiopathy" with
      Raynaud's phenomenon (author's transl)].
AB  - A hemodynamic research was carried out by the authors in ten patients affected
      with upper limb "vibration angiopathy", as well as in ten healthy control
      subjects. Digital artery flow and systolic, diastolic and mean pressures were
      measured, and vascular resistances and the so-called "systolic index" calculated,
      both in basal condition and following hand warming. In patients with "vibration
      angiopathy" fingers were examined, which on a previous arteriographic study
      showed the most and the least severe arterial lesions, respectively. No
      statistically significant differences were detected between the mean values of
      the hemodynamic indices obtained from the most and the least involved fingers,
      respectively, as well as between such values and the control subject ones. These
      results would suggest--even with due reservation on account of the relatively
      small number of cases and of their different features--that digital artery
      lesions, as shown by arteriography, have no definite hemodynamic significance.
      The lack of a statistically significant decrease of the digital artery mean
      pressure, compared to control subjects, supports the hypothesis that Raynaud's
      phenomenon in "vibration angiopathy" is not due to a transmural pressure fall.
      Finally, the lack of correlation between the severity of arterial lesions and
      Raynaud's phenomenon site suggests that the vasomotion impairment which causes
      the phenomenon is not related to such lesions.

PMID- 1030759
TI  - [Remarks on the nervous disturbances observed during an occupational medicine
      survey in workmen employed in a metal container manufacturing plant (author's
      transl)].
AB  - The authors report the results of a survey carried out in order to investigate
      psychic disturbances in subjects working in a metal container manufacturing
      industry. The manufacturing process is described and an attempt made to analyse
      the relationships among its evolution, work organisation--mainly referring to
      working group composition--and work division levels reached. The possible
      influences of noxious environmental factors on the onset of the psychic
      disturbances observed are examined. The obtained data are analysed and the
      psychic disturbances classified as: 1) anxious, 2) depressive, and 3)
      psychosomatic in nature; hypotheses are formulated in order to explain the higher
      frequency of almost all reported disturbances in female compared to male workers.
      Data are reported concerning psychotropic drug treatment as well as psychiatric
      hospitalization in the examined subjects; and their higher prevalence in
      comparison with the mean general population data is underlined. Finally, some
      remarks are made on methodology problems, and a correct setting up of the
      technician/homogeneous working group relationship is said to be the fundamental
      support for a profitable survey such as the one performed by the authors.

PMID- 1030760
TI  - [Sensitometric characteristics of medical roentgenographic and fluorographic
      films. Sensitivity of the amplifying screens combined with a film].
AB  - Factors affecting the degree of sensitivity of roentgenographic and
      radiofluorographic films and of their combinations with fluorescent screens are
      considered. A method of films exposure with a roentgenosensitometer permitting it
      to determine the sensitivity in conditions closely approaching the ones used in
      practice and corresponding to the minimum of the isoopaque is suggested. A way
      for determining the sensitivity of films in m2-mJ1 and lx-1-c-1 is indicated.
      Numerical values for the sensitivity of the films and their combinations with the
      screens are given. It is shown that with Eef = 38 keV, T = 20 degrees C, exposure
      time of 0.4--1 sec and optical density 1.00 over general focusing the lower limit
      of the X-ray RM-1film sensitivity to the light of CaWO4-screens is 38 m2-mJ-1 and
      of the fluorographic film Pphi-3 to the light of the Zn0-68Cd0-32S--Ag-screens --
      14.6 m2-mJ-1 or 30 lx-1-c-1.

PMID- 1030761
TI  - [Disinfection chambers: Classification and terminology].
AB  - To draw up a scientifically-grounded classification of and terminology for the
      chamber-type  disinfection equipment a classificational scheme of notions has
      been worked out, the most essential characteristics were laid at its basis, such
      as operational conditions, the shape of the working chamber, the method of
      charging and disinfection, as well as heating the chamber.

PMID- 1030762
TI  - [Sterilization of the pumping units of the apparatus for artificial circulation
      AIK-5 and AIK-5M].
AB  - Materials on clinical application in cardiosurgery of Soviet-made apparatus for
      extracorporeal circulation, models (formula: see text) and (formula: see text)
      are presented. Modification of these apparatus aimed at securing separate
      sterilization of its pumping units and setting them in place as a complete
      aggregate is described. This is achieved by providing the pumping assembly with
      articulated lock bolts and locating grips diametrically on the faceplate of the
      pump over which, to temporarily fix the cover with distributing valves and the
      pump's diaphragms, a rubber plait is hooked on.

PMID- 1030763
TI  - [Appliance for linear pressure changes in the tourniquet of the apparatus for
      automatic measurement of arterial pressure].
AB  - A linearizer allowing it to reduce the deviation from linearity down to not more
      than 5 per cent during pressure measurement from 300 to 20 mm Hg has been
      designed for indirect measurement of arterial pressure. The resulting estimated
      relation between pressure changes in the cuff and the paying out time makes it
      possible to construct linearizers for various maximal pressure values in the cuff
      with the due regard for the environmental conditions.

PMID- 1030764
TI  - [Certain technical aspects of assisted circulation].
AB  - The paper treats of issues concerned with the control, designing of the drive and
      operating mechanisms of the equipment for assisted circulation, working on the
      principle of an oriented presure change in the cardio-vascular system. Problems
      relating to the cardiosynchronization of the therapeutic action, constructing a
      drive based on the use of a linear direct current motor and to the demands placed
      on the actuating mechanisms are discussed.

PMID- 1030765
TI  - [Diffusion of oxygen and carbon dioxide in a stationary membrane oxygenator].
AB  - Univariate diffusion of oxygen and carbon dioxide through a selective membrane of
      a stationary membranous oxygenator (SMO) and moving blood film is considered.
      Through the use of a precise exponential approximation of the oxyhemoglobin
      dissociation curve [S (p)=1--ae-bp] a partial oxygen pressure distribution [p
      (x)] along the SMO membrane and a transcedental equation for estimating the value
      for partial pressure (pa) of the arterialized blood and the SMO efficiency with
      reference to oxygen have been obtained. A somewhat less exact logarithmic
      approximation of the summary blood oxygen concentration [C1=a1+b1ln(p--po)]
      enables it to arrive at an analytical expression for calculating the SMO
      efficiency with reference to oxygen in a positively definite form. On the other
      hand, by using logarithmic approximation of the summary carbon dioxide
      concentration proceeding from the partial CO2 pressure in the blood a partial CO2
      pressure distribution along the membrane, as well as an analytical expression for
      estimating the SMO efficiency with reference to carbon dioxide could be obtained.

PMID- 1030766
TI  - [New construction of an orthotopic heart prosthesis made of fluorosiloxane
      rubber].
AB  - A new design of orthopedic heart prosthesis with artificial ventricles of the
      saccular type -- model (see text) is described and results of its test-trials are
      reported. All the components of the heart prosthesis are made of fluorosiloxan
      rubber.

PMID- 1030767
TI  - [Physiotherapeutic apparatus as a source of air ionization in the rooms].
AB  - The extent of the air ionization in rooms accomodating physiotherapeutic
      apparatus is assessed. Subject to determination are main characteristics of
      ionization, such as: the unipolarity coefficient, the ionic air pollution factor,
      the life time of ions. Formulas for calculating mean concentration of ions and of
      the ionization energy liberation are cited. Recommendations for reducing the ions
      concentration are given.

PMID- 1030768
TI  - [Automatic regulator of venous pressure and venous outflow in the perfusion
      system].
AB  - A scheme for automatic regulation of the venous pressure and venous blood outflow
      during extracorporeal circulation is proposed. The system consists of a
      photoelectric sensor placed on a tube led out of the major venous trunkline, a
      converter and an electromechanical eccentric clamp that compresses the venous
      trunkline, all of which secures stabilization of the controlled values.

PMID- 1030769
TI  - [Signaling indicator of ventricular fibrillation].
AB  - The purpose of the work was to design an appliance for reliable detection of
      ventricular fibrillation. Frequency-amplitude spectrum of electrocardiograms
      taken in dogs with normal rhythm and fibrillation, as well as the impulse ratio
      in normalcy, tachycardia and in fibrillation were investigated. An appliance for
      automatic separation of ventricular fibrillation by referring to pulse ratio is
      described. The designed device is shown to have a high degree of discrimination
      and noise-immunity.

PMID- 1030770
TI  - [Air flow rate converter errors depending on the manufacturing precision].
AB  - Among the most promising converters of air (gas) flow rate into pressure
      differential employed in systems for the respiration parameters measurement
      should be counted the ones based on the viscous friction resistance, made in the
      shape of plane-parallel channels formed by packs of plates, with pressure take
      off along sections of the laminary flow from each channel via orifices and
      collectors Individual converters of the same type and size may differ
      substantially from one another in their conversion ratio, depending upon the
      degree of precision with which the instruments are made, and then mainly due to
      deviations in the thickness of the plates (the height of channels). In order to
      exclude such variations and to obtain a standard signal it is recommended that
      the making of the instruments  should include a tuning operation of the clear
      opening area in the resistance, or correction of the distance between the
      pressure take-off points. This will make it possible to utilize standard
      secondary convertes and thus cut down the cost of measuring systems incorporating
      such devices.

PMID- 1030771
TI  - [Protective measures against increase of the potential of a "grounded" passive
      electrode of the electrosurgical apparatus].
AB  - Causes accounting for the occurrence of high-frequency induced burns, one of the
      most common types of damage inflicted on patients during electrosurgical
      interventions, are considered. Different variants of circuits indicating the
      emergence of a leakage current passing to the ground via the patient's body when
      this comes in contact with a grounded object are analyzed. Recommendations for
      the protection of patients are listed.

PMID- 1030772
TI  - [Cryoprobes in the treatment of vascular occlusive diseases].
AB  - Application of cryosurgical methods offers good promise in the clinic of general
      surgery and especially in that of vascular surgery. In tests conducted on 20 dogs
      the authors showed that on the third-seventh day after reproduction in test
      animals of an acute or arterial thrombosis the thromb could be completely removed
      from the blood vessel, on its being fixed by freezing to a special cooled rod
      (cryothrombectomy). By means of a cooled rod to which the vein is being fixed by
      freezing cryovenectomy can be performed. The method merits further elaboration
      and clinical investigations.

PMID- 1030773
TI  - [Instrument for cryogenic surgery of subatrophic and atrophic rhinitis and
      pharyngitis].
AB  - To treat cryogenically the nasal and pharyngeal mucosa an instrument has been
      devised in which the supply of cold carrier is regulated by changing pressure in
      the reservoir and by using interchageable needles of different diameter. The
      direction of the cold carried stream is changed depending upon the needle chamfer
      angle and the arrangement of holes in its wall. The procedure used in applying
      cryogenic action is simple and may be used in treating outpatients.

PMID- 1030774
TI  - [Use of cryogenic technic for the treatment of tumors of the oral cavity and
      pharynx].
AB  - To achieve cryodestruction of neoplastic tissues or preliminary freezing tumours
      for reducing bleedings cryogenic technique was employed in the treatment of 60
      patients with buccal and pharyngeal neoplasms. Cryogenic action on the buccal and
      pharyngeal newgrowths is a promising method of therapy, and for it most suitable
      is cryoprobe. Recommendations for further improvement of cryogenic instruments
      are given.

PMID- 1030775
TI  - [Improved model of cryosprayer].
AB  - For local congelation of pathologically altered sections of the tissue the design
      of an earlier devised cryosprayer has been improved. The newly constructed model
      is convenient in handling, reliable in operation, has low weight and overall
      dimensions and ensures good visual view of the operation field. The new model of
      the cryosprayer is recommended for use in the stomatological practice, for
      treatment precarcinous affections of the buccal mucosa and dental pulp.

PMID- 1030776
TI  - [Rheographic method of examination during conduction of functional tests with
      physical exertion].
AB  - In most of the rheographic procedures in use the hemodynamics is studied at rest
      with retained breathing at expiration. The rheographic method of examination may
      furnish a wealth of new and extremely valuable information when employed during
      institution of functional load tests (physical loads, in particular). A design of
      an electrode is proposed whose use with an integral method of the information
      readout enables it to obtain a high-standard rheographic curve with the examinee
      performing physical work on a veloergometer.

PMID- 1030777
TI  - [Complex apparatus for remote study of external respiration].
AB  - A complex set of instruments ensuring telerecording of the basic ventilation and
      gas exchange values is described. The set provides for the possibility of
      delivering various gas mixtures to the examinee. The set was mounted, tested and
      operated with a centrifuge under radial overloads of up to 12Gx. A six-year
      experience of its operation demonstrated its reliability, accuracy and
      reproducibility of the results obtained.

PMID- 1030778
TI  - [Accuracy of reproducing images of objects in electro-roentgenographic
      examination of various organs].
AB  - Most characteristic distortions of electroroentgenographic and
      electroroentgenotomographic images obtained with the help of Soviet-made (see
      article) and (see article) units are reviewed. Images of different nature
      (positive, negative) are compared. Qualitative and quantitative assessment of
      distortions is give. An electroentgenographic image is contrasted against an
      analogous image on a PM-1 film. The dependance of the object's structure
      discernability on its localization on the electrooentgenographic layer is
      investigated.

PMID- 1030779
TI  - Reflective and impulsive children: strategies of information processing
      underlying differences in problem solving.
AB  - The hypothesis that impulsive children differ from reflective children in their
      preferred strategy of information processing, based on extent of stimulus
      analysis, was investigated. The experiments employed different age groups and a
      variety of tasks, including matching, grouping, recall, and concept attainment.
      Stimuli were presented both visually and auditorily and included both visually
      and aduitorily and included both verbal and pictorial matrials. The tasks
      required verbal and nonverbal responses and varied in the level of stimulus
      analysis necessary for successful performance. The subjects' strategy was
      assessed by the quality of their performance on tasks requiring detail versus
      global processing, and by the strategy they chose to adopt in tasks where either
      detail or global processing led to successful performance. While reflective
      children performed better on tasks requiring detail analysis than on tasks
      requiring global analysis, impulsive children showed the reverse trend.
      Furthermore, when successful solutions could be reached via either a global- or a
      detail-processing strategy, impulsive children who adopted the former were
      equally as successful as reflective children who adopted the latter strategy. It
      was concluded that, contrary to existing views, impulsive children are not
      inferior to reflective children in general potential or problem-solving ability.
      Rather, the inferior performance of impulsive children frequently reported in the
      literature may be due to incompatibility between their preferred global
      processing strategy and the detail analysis typically required for successful
      performance.

PMID- 1030780
TI  - Spontaneous regression of hematologic cancers.
AB  - Spontaneous regression of hematologic cancer is extremely rare. Data gleaned from
      the literature and from previously unreported cases allow certain interesting
      general conclusions. Spontaneous remission of acute leukemia is associated with
      bacterial infection and is of short duration, weeks to months. Spontaneous
      regression of lymphoma or plasma cell dyscrasia is often of substantial duration,
      months or years, and frequently is associated with viral infections. Spontaneous
      regression of chronic lymphocytic leukemia is also of significant duration and
      has been associated with the occurence of a new primary carcinoma in one-third of
      the cases.

PMID- 1030781
TI  - Spontaneous regression of neuroblastoma.
AB  - Case of spontaneous regression of neuroblastoma continue to occur in the present
      multimodal therapy era at institutions where physicians are prepared to withhold
      treatment on certain patients with residual primary or metastatic disease. From a
      survey of the 22 member institutions of Children's Cancer Study Group, seven
      hospitals submitted data on 24 neuroblastoma patients whose disease underwent
      regression after minimal, unusual, or no treatment. An analysis of these patients
      and of 33 patients form two large series in the literature shows that the
      majority of patients are infants with Stage II or Stage IVS disease. The
      spontaneous regression usually consists of complete disappearance of the disease,
      but in some neuroblastomas, maturation to ganglioneuroma takes place. The various
      factors that may influence regression are discussed.

PMID- 1030782
TI  - Latent carcinoma and carcinoma in situ.
AB  - Lesions exist in the cervix that are diagnosed as carcinoma in situ; some may
      progress to invasive carcinoma and some may regress. Many are probably
      overdiagnosed, may represent effects of promoting agents rather than intiating
      agents, and may entail risk for the patient in that the lesion may be an unusualy
      good target in carcinogenesis. Latent carcinomas are small foci of initated cells
      unable to express their malignant phenotype because of environmental controls.
      Latent cells are produced in experimental carcinogenesis and occur in spontaneous
      tumors as G-O stem cells.

PMID- 1030783
TI  - [Case of giant intra-petrous and intra-cavernous internal carotid aneurysm in a
      child].
AB  - The authors report the case of an eight-year-old girl hospitalised for severe
      headache with paroxysmal left otalgia, vomiting, aprexia, paralysis of the left 6
      th cranial nerve and slight left facial weakness. Left carotid arteriography
      revealed a very large aneurysm of the internal carotid, involving its entire
      intra-petrous and intra-cavernous course. Treatment consisted of ligation of the
      internal carotid in the neck. Postoperative angiographic studies showed complete
      exclusion of the aneurysm, and it was unecessary to carry out "trapping" by
      ligation of the supra-cavernous carotid, as had initially been envisaged. The
      postoperative course was uneventful : immediate disappearance of otalgia,
      secondary complete recovery of the oculo-motor involvement and facial paresis.
      The absence of any infections or traumatic past history, together with the young
      age of the patient, represent arguments in favour of the congenital origin of
      this intra-petrous carotid aneurysm.

PMID- 1030784
TI  - [General anesthesia during neurosurgery in sitting position].
AB  - Sitting position during surgery of the posterior fossa is very convenient for the
      neurosurgeon but can be dangerous, specially concerning the risk of air-embolism.
      We discuss the major problems of this special position, and the modifications of
      respiratory and hemodynamic functions from our experience on 84 cases. We study
      the monitoring of these patients during surgery, with special emphasis on
      prevention and detection of air-embolism with the capnograph. With the protocol
      suggested we can avoid major risk in this position.

PMID- 1030785
TI  - Effects of estrogen on the electrical activity of identified and unidentified
      hypothalamic units.
AB  - Experiments performed on unanesthetized ovariectomized female rabbits
      demonstrated the effects of estradiol benzoate (EB; 20 microng i.v.) on the
      electrical activity of hypothalamic units which send their axons to the median
      eminence. Of a total of 1,840 cells recorded in hypothalamic and preoptic areas,
      46 (2.5%) were antidromically activated by stimulating the median eminence. Under
      the present experimental conditions, EB induced a progressive diminution in the
      mean firing rate of these cells observed throughout the recording period (30-120
      min). In addition to cells projecting to the median eminence, neurons which could
      not be antidromically invaded using our techniques were observed to be sensitive
      to estrogen. Estrogen administration produced a long-lasting inhibition of
      antidromically activated cells and a depression of much shorter duration (15-20
      min) of unidentified nonstimulated units. These data suggest the existence of two
      types of hypothalamic neurons sensitive to estrogen.

PMID- 1030786
TI  - Neuroendocrine and electroencephalographic sleep changes due to acute amphetamine
      ingestion in human beings.
AB  - Amphetamine, a clinically used sympathomimetic central-acting drug, was
      administered in Spansule capsules in a blind schedule to 8 normal obse volunteers
      in a daily (8 a.m.) single 15 dose for 7 days. The study, conducted in the
      metabolic ward, included two 7 day placebo periods (pre- and post-drug). During
      the 1st placebo period, all subjects exhibited within the 1st 2 h of sleep a
      clear and significant nocturnal increase of growth hormone (GH) closely related
      with sleep stages 3 and 4. Thyrotropin (TSH) increase was observed between 01.00
      to 04.00 h and was accompanied by a reduction of thyroxine (T4) levels. Cortisol
      levels presented their characteristic rhythm, clearly associated with paradoxical
      sleep (REM). Amphetamine significantly reduced stages 3 and 4, as well as REM
      sleep, and increased stage 2. GH and cortisol circadian profiles were preserved,
      although their magnitude was diminished. The extent of nocturnal TSH and T4
      changes was significantly reduced. Drug withdrawal was accompanied by a rebound
      of REM sleep and a trend to recover the pretreatment TSH and T4 temporal profile.
      These results suggest that adrenergic neurotrasmitters may be a significant
      modulating system for TSH and cortisol, whereas GH nocturnal secretion may be
      influenced by different mechanisms.

PMID- 1030787
TI  - [Contribution of the "limulus test" to the diagnosis of endotoxemias and
      meningitis due to gram negative bacteria].
AB  - The "limulus test" may be used to detect the endotoxins of Gram negative
      organisms. Applied to the cerebrospinal fluid (79 specimens from 64 patients) it
      proved itself to be a very important contribution to the differential diagnosis
      of purulent meningitis (95% positive results, no false positives). However it can
      be used on the plasma only in patients with shock of suspected endotoxic origin.

PMID- 1030788
TI  - [Modification of properties of drugs combined with polymers. I].
AB  - The article reviews the papers on modifying the properties of drugs by their
      administration in the form of a mixture with polymers, or combination of the
      drugs and polymers using coordinative or ionic bonds. In many cases the
      combination of drugs and polymers by chemical means or preparation of a mixture
      of drugs and polymers prolongs and increases the effectivity of drugs, increases
      their solubility, decreases their toxicity, and modifies their distribution in
      the organs.

PMID- 1030789
TI  - Growth hormone and prolactin in the fetus.
AB  - Growth hormone is released from pituitary glands maintained in tissue culture as
      early as 5 weeks after conception. It has been identified in the fetal anterior
      pituitary gland by immunologic and biologic techniques between 7 and 15 weeks of
      gestation. Immunoreactive pituitary GH levels increase rapidly between 10 and 14
      weeks of gestation to maximal levels at 30-34 weeks. Serum GH levels are
      detectable by 10-weeks postconception and reach maximal values at 20-24 weeks
      declining thereafter until term. Pospartum GH concentrations decline over several
      weeks to lower values, GH levels remaining higher in preterm than in term
      infants. The biologic role of pituitary GH in the fetus is unknown. Although
      birth-weights and lengths are reported to be normal in infants with anencephaly,
      aplasia, or hypoplasia of the pituitary gland and in isolated deficiency of
      growth hormone, in whom pituitary and serum GH levels are low, careful inspection
      of large series of such infants reveals that their birthweights may indeed be low
      and that cell numbers in many organs may be subnormal. In experimental animals
      prenatal administration of GH increases maternal weight and gestational length.
      Reported effects on neuronal growth and adult intelligence of animals treated
      prenatally may reflect these phenomena rather than a direct transplacental effect
      of GH. Prolactin is also elaborated by the pituitary gland of very young human
      fetuses. It has been identified immunologically by 10-weeks gestation and
      biologically at 18 weeks. Pituitary content of immunoreactive prolactin remains
      low until 16.5-weeks gestation and then increases steadily until term. The plasma
      concentration of prolactin is low until 30-weeks gestation and increases
      thereafter until term. In anencephalic fetuses prolactin levels are normal and
      respond to appropriate stimuli. Very high concentrations of (possibly fetal)
      prolactin are found in the amniotic fluid. The role of prolactin in the fetus is
      also unknown. It has been suggested that prolactin may be important for growth of
      the fetal adrenal cortex and/or for suppression of the immune response during
      pregnancy. It is apparent that a great deal of additional work is necessary
      before the importance of either growth hormone of prolactin for normal fetal
      growth and development will be known.

PMID- 1030790
TI  - Blood pressure, edema and proteinuria in pregnancy. 4. Blood pressure
      relationships.
AB  - The significance of these and related data will be discussed in greater detail
      during the subsequent course of this workshop. For now, we can sum up our
      findings with the following general statements concerning this analysis: 1. Blood
      pressure elevation occuring alone during the course of pregnancy, in the absence
      of edema and/or proteinuria, affects perinatal survival adversely. 2. This
      relationship is most marked among nulliparas in the age range 20-34 years and is
      less pronounced, but still evident, in young nulliparas and in multiparas of
      comparable age. 3. The effect is greater among black patients than among white
      patients in the median-aged nulliparas and multiparas, but this difference is not
      mirrored in the young nulliparas studied. 4. Blood pressure elevations during
      weeks 20-28 of pregnancy result in much higher subsequent perinatal losses in
      white nulliparas (both median and young age groups) than comparable elevations
      earlier or later in pregnancy. 5. Among black nulliparas of median age, maximal
      blood pressure effect on outcome is encountered at the sixteenth week (the
      earliest available data), with continuing significant increases until the twenty
      eighth week, and there is another increment at term. In younger black patients,
      the results from 20 through 28 weeks parallel those seen in white patients, but
      with an additional peak at term. 6. among multiparas, maximal effect occurs at 24
      28 weeks in both black and white groups. 7. The critical blood pressure levels
      are significantly lower in early pregnancy than in late pregnancy. 8. Critical
      levels of blood pressure with advancing pregnancy appear to parallel the trend in
      mean blood pressures determined to exist for this series. 9. Utilizing blood
      pressure distribution data to set limits statistically, we find very meaningful
      increments in perinatal mortality rates for nulliparas presenting blood pressure
      elevations beyond the 95 percentile point. This holds also for diastolic or
      systolic levels when these are examined independently because neither alone
      yielded more convincing data than blood pressure combinations condidered
      together.

PMID- 1030791
TI  - Blood pressure, edema and proteinuria in pregnancy. 6. Proteinuria relationships.
AB  - 1. The blood pressures of pregnant patients with proteinuria seem to be no higher
      than the levels of blood pressure in patients with no proteinuria. The presence
      of proteinuria and pregnancy in the absence of blood pressure elevation increases
      perinatal mortality above the values where blood pressure elevation occurs alone.
      This relationship is most prominent among nulliparous median-age pregnant
      patients. Even though the number of patients is small, the highest rates occur in
      the young white nullipara from the sixteenth to twenty-third week of pregnancy.
      Attempts to compare black and white median-aged nulliparas are meaningless
      because of the tremendous variability of data. 2. The findings in all cohorts
      with proteinuria were essentially the same as those in Cohorts I, II and III.
      Proteinuria of 2+ or greater occurs more frequently in black than in white
      gravidas. 3. Our observations indicate that perinatal mortality rates in patients
      with proteinuria are, for the most part, at least twice the rates of patients
      without proteinuria. 4. The volume of data available is insufficient to determine
      whether proteinuria influences prematurity rates or mean birth weights. However,
      our data suggest that some vascular or renal lesion must be affecting perinatal
      mortality. 5. The small number of patients in the proteinuria study group does
      not permit meaningful comparisons with the patient group presenting no edema or
      proteinuria. 6. Adherence to suitable criteria for discovering and measuring
      proteinuria is necessary to make the diagnosis of preeclampsia. These criteria
      include careful collection of urine in the clinic or hospital, utilization of
      acceptable standard testing methods, and the application of uniform principles of
      medical practice to the overall care of obstetric patients. 7. The data are
      presented, not interpreted. However, we cannot discount the value of the present
      data in suggesting the urgent need to restudy more of the current data available.
      It also seems desirable to initiate another program to investigate a smaller
      group of patients made up of the same sequential cohorts where it may be possible
      and more practical to apply strict supervision of statistical design, patient
      care, personnel, laboratory testing, data recording, data processing and
      reporting and statistical analysis.

PMID- 1030792
TI  - Blood pressure, edema and proteinuria in pregnancy. 7. Edema-plus-proteinuria
      relationships.
AB  - 1. A total of 488 pregnancies had the combination of two-plus or more proteinuria
      and edema of the hands and face. Of these, 208 were white and 280 were black
      gravidas. In the white gravidas, 8 fetal and neonatal deaths occurred with a
      perinatal mortality of 38.5 per 1,000. There were 13 perinatal deaths in the
      black subgroup with a perinatal mortality rate of 46.4 per 1,000. The overall
      perinatal mortality rate was 43.0 per 1,000, which could be compared to the
      overall perinatal mortality rate of 32.8 per 1,000 for the segment of the study
      population without edema or proteinuria. This underscored the implication of
      increased hazard to fetal outcome of these clinical signs in combination. 2. The
      analysis of the matrix data showed scattered rates throughout gestation in white
      median-age nulliparas. Their black counterparts had comparable increased
      mortality rates. In the white multiparas of ages 20 to 34 years, the highest
      rates were found at relatively low blood pressure levels. The black median-age
      multiparas had rates associated with higher pressure readings, especially at or
      above 125/75. In teenage mulliparas with edema and proteinuria, perinatal
      mortality rates were similar for both subgroups and were found in somewhat lower
      blood pressures. 3. The incremental analysis was remarkable in that rates were
      scattered widely in the white subgroups, but tightly clustered in the black
      subgroups. The black median-age nulliparas had perinatal mortality concentrated
      about 115 to 134 mm. Hg systolic and 65 to 84 mm. Hg diastolic. The overall
      mortality rates of this subgroup were the highest of the subgroups studied. The
      black 20 to 34 year old multiparas had highest coassociated deaths in the 134-154
      mm. Hg systolic levels throughout pregnancy. The clustering effect was most
      pronounced in black teenage nulliparas in both systolic and diastolic blood
      pressure groups at much lower levels. 4. The use of a critical cut-off blood
      pressure level of 125 mm. Hg systolic and 75 mm. Hg diastolic emphasized the
      combination factor effect, especially by the increased perinatal mortality rates
      in the black median-age subgroups of both nulliparas and multiparas. In the white
      median-age subgroups the rates were not uniformly affected. The teenage
      nulliparas as a group showed increased mortality rates with lower pressure levels
      in general. This was seen when the diastolic level was above 75 mm. Hg. 5.
      Perinatal mortality rates of nulliparas were increased by proteinuria and edema.
      This increase was great in the case of the 20 to 34 year old black nulliparas,
      particularly in association with increased blood pressure. Trends are not so
      apparent for the white median-age nulliparas. Nulliparas of 19 years of age or
      less have higher perinatal loss with edema and proteinuria, but this is not
      necessarily augmented with blood pressure elevation. This is notably so in
      teenage black nulliparas in the early periods of gestation and at term.

PMID- 1030793
TI  - Blood pressure, edema and proteinuria in pregnancy. 8. Evaluation of criteria.
AB  - We have reviewed some of the potential sources of errors in our study data with
      regard to the criteria used clinically to diagnose toxemia. The constraints
      imposed are rather clear. Despite these limitations (or perhaps because of them),
      we are impressed that the trends noted in the foregoing studies reported in this
      workshop relating to gestational progression and perinatal outcome have been
      encountered. Because such relationships have been uncovered using relatively
      coarse study parameters, we are tempted to infer that they are likely to be
      correct. If indeed such trends were spurious or weak relationships, the
      indelicate clinical signs at our disposal (in terms of their reliability and
      reproducibility) should not have been expected to demonstrate them so cogently.
      At the same time it should be made clear that more subtle correlations may exist,
      other than those herein shown, which perforce cannot be demonstrated or proved
      because of the restrictive unreliability of the clinical observations.

PMID- 1030794
TI  - Blood pressure, edema and proteinuria in pregnancy. 9. Proposal for
      classification.
AB  - The frequency distributions of blood pressures in large populations fail to show
      two groups, one normotensive and the other hypertensive. In the spectrum of
      pressures, some people merely have higher levels than others and division of
      abnormal from normal is artificial and arbitrary, although it is useful for
      prognosis. The blood pressure of 140/90 as the conventional dividing line does
      not seem to be appropriate in pregnant women. From the standpoint of fetal
      prognosis, a level of 125/75 before the thirty-second week and 125/85 thereafter
      seems more reasonable. Moreover, those levels are close to the 120/80 that
      Robinson and Brucer specified as the upper limit of normal for all adults and are
      close to the 130/70 and 120/80 that the eminent British authority, F.J. Browne,
      used successively in the diagnosis of hypertensive disorders in pregnancy. If the
      standard of 125/75 were adopted, however, a quarter of all pregnant women would
      be hypertensive in the second trimester and half in the last month, which are
      disturbingly high proportions. For the diagnosis of preeclampsia, a rise in blood
      pressure probably is more significant than an arbitrary level. The usual blood
      pressure in midpregnancy merely defines the patient's place in the spectrum.
      Figure 9-1 indicates that in white nulliparas the diastolic pressure rises an
      average of 10 mm. Hg in the middle of the third trimester. If the mean and median
      are close together, greater increases would occur in half of the women. The
      classification of the American Committee on Maternal Welfare and of the Committee
      on Terminology of the American College of Obstetricians and Gynecologists specify
      increases of 30 mm. Hg or more in the systolic or 15 mm. Hg or more in the
      diastolic pressures as criteria of preeclamptic hypertension. pperhaps the rise
      in diastolic pressure should be set at some greater value. Our analysis of data
      made thus far cannot decide that issue. The next phase of the study will include
      analyses in individual women of the times, magnitudes, persistence or transience,
      and the like of changes in blood pressure, edema, and proteinuria. Such data will
      afford much more information than can be derived from the preliminary studies
      reported here. Although edema of the hands and face may be more common in
      preeclamptic than in normal women, such edema is so common in normal pregnancy as
      to suggest that it usually is normal. In our data, edema seems to bear no
      relation to hypertension or proteinuria. The triad of signs -- hypertension,
      proteinuria, and edema -- is generally accepted as characteristic, though far
      from specific for preeclampsia. Our data support Hytten's conclusion that edema
      should by dropped from the triad. There is some indication, however, that some
      edema is abnormal and that it is associated with an adverse effect when it
      coincides with proteinuria late in pregnancy.

PMID- 1030795
TI  - Humoral control of cell proliferation: the role of fibroblast growth factor in
      regeneration, angiogenesis, wound healing, and neoplastic growth.
AB  - The Fibroblast Growth Factor (FGF) is a mitogenic agent in the brain and
      pituitary of mammals. Recent investigations of the effect of FGF on diverse cell
      types has shown that FGF stimulates the division of cells from a wide variety of
      tissues of mesodermal origin including fibroblasts, chondrocytes, myoblasts,
      smooth muscle cells, glial cells, normal adrenal cells, and the Y1 adrenal cell
      line. Cell types of endodermal or ectodermal origin do not appear to be sensitive
      to FGF. Since FGF can be found in neural tissues and since it induces the
      proliferation of two cell types involved in the formation of regeneration
      blastemas (chondrocytes and myoblasts), we have investigated the possibility that
      FGF could be similar or identical to the neurotrophic factors present in nerve
      and responsible for the regeneration of limbs in lower vertebrates. Our results
      have shown that FGF could indeed substitute for the neurotropic factor and
      replace the nerves in inducing blastema formation and sustaining proliferation of
      mesenchymal cells which can differentiate into chrondrocytes and myoblasts. Since
      the blastema has been described as a benign tumor, the role of FGF in the
      formation of blastemas and benign tumors is currently under investigation. In
      addition to stimulating fibroblasts, FGF also has a striking growth-promoting
      effect on primary cultures of vascular endothelial cells. This suggests that FGF
      could be an angiogenesis factor. Thus, FGF, one of the most potent mitogenic
      agents found in tissue extracts has two properties expected of an agent which
      could induce tumors: it can induce blastema formation (direct mitogenic effect)
      and, through its mitogenic effect on endothelial cells, it could induce formation
      of capillaries (amplification step), permitting unlimited growth. Repair
      processes under FGF control will, under normal circumstances, lead to wound
      healing. In contrast, if cells become transplanted to the wrong environment
      (hormonal imbalance), growth factors such as FGF could make them proliferate in
      an anarchic way since negative feedback from surrounding cells will be lacking.

PMID- 1030796
TI  - Immunogenicity of tumor cells modified by trinitrobenzene suflonic acid (TNBS).
AB  - The ability of trinitrophenylated tumor cells to stimulate syngeneic antitumor
      response has been tested in 3 different tumor-host systems: A. Trinitrophenylated
      and inactivated Moloney induced YAC tumor cells (YAC-TNP) were able to induce the
      production of cytotoxic antibodies in low responding A/J mice, while inactivated
      YAC tumor cells (YAC-In) failed to induce such a response. Furthermore, A mice
      which were injected with YAC-TNP rejected 103 viable YAC tumor cells at a higher
      frequency than those injected with YAC-In. B. Trinitrophenylated and inactivated
      Gross virus induced G-35 tumor cells or Monoloney induced LSTRA cells (both
      syngeneic in BALB/c mice) were as immunogenic as nonmodified inactivated tumor
      cells. About 50% of the immunized mice survived indefinitely after injection of
      103 viable tumors. Fruthermore, spleen cells from mice primed with either
      modified or nonomodified G-35 cells responded in vitro to G-35 in a mixed
      leukocyte tumor interaction and generated specific cell-mediated cytotoxic
      activity to 51Cr-G-35 syngeneic tumors. However, the donors of the primed cells
      did not produce detectable cytotoxic antibodies to G-35. C. In vitro
      sensitization of C57B1 spleen cells by trinitrophenylated Mitomycin C treated
      syngeneic EL-4 generated a stronger cytotoxic response to EL-4 cells than
      obtained by sensitization with Mitomycin C treated EL-4 cells alone, The
      superiority of the sensitizing capacity of trinitrophenylated EL-4 was readily
      demonstrated in conditions which were suboptimal for nonmodified Mitomycin C
      treated tumor. Both theoretical and practical implications of these results are
      discussed.

PMID- 1030797
TI  - Measurement of lateral transport on cell surfaces.
AB  - This paper describes the principles and recent applications of two new methods
      for measuring rates of macroscopic lateral transport of fluorescent-labeled
      particles on the surface of individual cells. Both methods are based on
      microfluorimetric measurements of fluorescence intensity from a small open region
      (greater than or equal to 1 micronm radius) on the cell surface. Transport rates
      are measured from the rates at which the measured fluorescence intensity changes
      due to entrance or departure of fluorophores from the region. One method,
      "Fluorescence Photobleach Recovery" (FPR), uses a brief intense pulse of light to
      create an initial concentration gradient over the spot by irreversible
      photochemical destruction of fluorophores. The rate of fluorescence recovery due
      to transport of unbleached fluorophores into the observation region is the
      primary experimental datum. The other method, "Fluorescence Correlation
      Spectroscopy" (FCS), is based on a statistical analysis of spontaneous
      fluctuations of numbers of fluorophores in the observation region and does not
      require a perturbation to generate an initial concentration gradient. FCS is
      mainly useful to measure relatively fast processes (D greater than or equal to
      10(-9) cm 2/sec) in stable systems; FPR can be used to measure both slow and fast
      transport in less stable systems. Using both FCS and FPR, the diffusion
      coefficient of a fluorescent lipid probe in rat myoblast plasma membranes was
      measured to be D = (9 +/- 4) X 10(-9) cm2/sec over a range of at least 4 micronm.
      FPR was used to measure the lateral mobility of the fluorescent labeled lectin
      concanavalin A complexed to myoblast plasma membrane "receptors." A fraction of
      the complexes were immobile on the time scale of the experiment (D less than 8 x
      10(-12) cm2/sec). The remainder of the complexes had effective diffusion
      coefficients far smaller than expected from the measurements on the lipid probe
      (8 x 10(-12) less than or equal to D less than or equal to 3.3 x 10(-11)
      cm2/sec). Moreover the mobility depended on the valence, dose, and time of
      occupancy of the lectin on the membrane, suggesting that an aggregation of
      complexes was occurring during the experiment. Cytochalasin B decreased the
      mobility of complexes, suggesting an influence of microfilaments on the transport
      process. Neither azide nor colchine affected measured transport rates. These
      results indicate the operation of constraints on the mobility of the lectin
      receptor complexes beyond that exerted by the viscous resistance of the lipid
      bilayer membrane matrix. The two types of interactions revealed by our current
      experiments - interactions of the complexes with microfilaments and with each
      other (aggregation) - seem insufficient to account entirely for the low observed
      mobility.

PMID- 1030798
TI  - Direct observation of membrane movement by electron microscopy.
AB  - Motions of wet lipid bilayer membranes and plasma membranes of human erythrocytes
      were observed directly in an electron microscope, using the techniques of
      selective area diffraction, diffraction contrast imaging and electron opaque
      markers. The motions are measured as functions of temperature. At the liquidus
      state of the membrane, the lateral diffusion coefficient is deduced from the
      Brownian motion of the labeling particles. The coefficient is measured to be 1.1
      x 10(-10) cm2/sec. for a bilayer of an equimolar mixture of cholesterol and
      dipalmitoylphosphatidylcholine at 20 degrees C. The value for human erythrocyte
      membrane at 37 degrees C is similar. At the temperature where phase separation
      occurs, motion is detected as the solidus domains floating on a liquidus medium.
      Below the transition temperature, the solidus domains move relative to one
      another along the domain boundaries, the drift velocity being 3 x 10(-6) cm/sec.
      for the above mentioned bilayer, at 4 degrees C. Together with specific labeling
      technique, the electron optical method may be used to study the movement of
      specific sites relative to the membrane, on a scale beyond the resolving power of
      light microscopy. The use of scanning electron microscopy is discussed.

PMID- 1030799
TI  - Crosslinking of lectins and receptors in membranes with hetero-bifunctional
      crosslinking reagents.
AB  - 125I-Con A was reacted with the imidoester group of methyl 4-azidobenzoimidate
      and isolated from excess reagents on a Sephadex G-25 column. The hetero
      bifunctional crosslinking reagent has two dissimilar functional groups,
      imidoester and arylazide, instead of two identical functional groups found in
      conventional homo-bifunctional crosslinking reagents. The two functional groups
      react under different conditions and it is possible to react one first and to
      activate the other later. Here the reagents were attached to the lectins by the
      imidoester reactions, and the arylazides now attached to the lectins were
      intended for the later use to crosslink the lectins and receptors. Human
      erythrocyte ghosts were incubated with the activated lectins, unbound lectins
      removed, and irradiated with UV to photolyze arylazides, thus crosslinking the
      lectins to the receptors in membranes. Upon the solubilization and subsequent
      electrophoresis of the sample, a new band appeared on the gel. 125I-Con A was
      detected in band A, the new band, and band 3, one of the membrane glycoproteins,
      diminished in parallel to the appearance of band A. The concurrent appearance of
      band A accompanied by 125I-Con A and decrease of band 3 were significantly
      reduced, when ghosts were incubated with the activated lectins but were not
      irradiated, ghosts were incubated with nonactivated 125I-Con A and irradiated, or
      ghosts were incubated with the activated concanavalin A in the presence of alpha
      methylmannoside, the lectin inhibitor, and irradiated. The inhibitor removed a
      significant amount of the activated lectins bound to membranes, but failed to do
      so the activated lectins crosslinked into band A.

PMID- 1030800
TI  - Identification of a high molecular weight trans-membrane protein in mouse L
      cells.
AB  - We have developed a new method for identifying proteins which span the plasma
      membrane ("trans-membrane" proteins) of mammalian cells grown in tissue culture.
      The method involves labeling proteins exposed on the cell surface with 125I by
      the lactoperoxidase technique and then preparing sealed, "inside-out" membrane
      vesicles (phagosomes) from the labeled cells using the polystyrene latex bead
      procedure. These inside-out vesicles are then treated briefly with trypsin and
      analyzed by SDS-polyacrylamide gel electrophoresis for the presence of 125I
      labeled protein species which were degraded by proteolytic attack. Such proteins
      must be exposed on both the outer and inner membrane surfaces and, therefore,
      they must pass through the lipid barrier. This method is a general one in the
      sense that it is suitable for use with a wide variety of cell types, and here we
      show how it has been employed to prove that a particular high molecular weight
      polypeptide, called band 1, spans the plasma membrane of mouse L cells. Further
      studies of the band 1 polypeptide have demonstrated that it is preferentially
      exposed on the L cell surface during G1 phase of the cell cycle. Progression of
      cells from G1 to S is accompanied by a marked decrease in the availability of
      band 1 to iodination and it remains unavailable until cells re-enter G1. It is
      suggested that the band 1 polypeptide may be functionally involved in the
      regulation of cell proliferation.

PMID- 1030801
TI  - The role of drug delivery systems in cancer chemotherapy.
AB  - One approach to effective cancer chemotherapy is to maximize the exposure of
      tumor cells to cytotoxic drugs while minimizing the exposure of sensitive normal
      cells to such agents. This implies the need for control of the pharmacodynamics
      of anti-tumor drugs in terms of blood clearance kinetics, disposition in tissues,
      passage across membrane barriers, and interaction with metabolic pathways. A
      promising approach to pharmacodynamic control is the microencapsulation of drugs
      within liposomes. The clearance kinetics and tissue disposition of the drug is
      then dictated by the pharmacokinetic behavior of the liposomal carrier. The blood
      clearance rates and tissue uptake of liposomes themselves depend upon physical
      characteristics such as particle size and surface charge. It is also possible to
      promote specific interaction between cells and liposomes in vitro by preparing
      liposomes containing biological macromolecules such as lectin receptors. The
      potentialities of microencapsulation as an adjunct to chemotherapy are discussed.

PMID- 1030802
TI  - Biochemical analysis of cell adhesion to a substratum and its possible relevance
      to cell metastasis.
AB  - The evidence is reviewed that two types of cell attachment occur, depending upon
      the presence or absence of serum in the medium. In the absence of serum,
      attachment has many characteristics of a nonphysiological process. In the
      presence of serum, attachment occurs as a series of steps: adsorption of serum
      components onto the substratum, contact between the cell and substratum, initial
      attachment, and progressive attachments leading to cell spreading. Although there
      is a close interdependence of these events, they could be experimentally
      distinguished. Studies are reported indicating that cell spreading requires the
      adsorption of a specific serum glycoprotein onto the substratum surface. The
      relationship between cell adhesiveness and the altered behavior of malignant
      cells is discussed.

PMID- 1030803
TI  - Isolation and preliminary characterization of that part of the plasma membrane
      which is apposed to the substratum.
AB  - We have developed a membrane isolation technique which allows us to isolate that
      part of the plasma membrane which is apposed to the solid substratum (LPM) to
      which cells in vitro attach free of the remainder of the plasma membrane (UPM).
      Our evidence suggests that the UPM is essentially free of contaminating cellular
      organelles while the LPM may be somewhat contaminated with endoplasmic reticulum
      fixed to it during the isolation procedure. Characterization of the peptides of
      the UPM and LPM suggests that some membrane components are nonrandomly
      distributed to one or the other membrane fraction while the bulk of the membrane
      peptides appear to be present in both membrane fractions; Membrane components
      labeled with 3H-fucose or 3H-glucosamine show a 3--5-fold higher specific
      activity in the LPM than in the UPM. A number of iodineateable surface
      components, in particular the LETS protein, show a preferential localization to
      the LPM. The development of this membrane isolation procedure should allow us to
      begin investigating the molecular basis of differences in cell-substratum
      adhesion and cell motility, two functions assigned operationally to the LPM.

PMID- 1030804
TI  - Patching, microvilli, and the agglutination of normal and transformed cells.
AB  - Transmission and scanning electron microscopy were used to study possible
      structural correlates in the process of agglutination of several types of normal
      and transformed cells by Concanavalin A. In parallel studies we found that post
      confluence inhibition of cell division and agglutiniability of cells by
      Concanavalin A were not correlated with patching of surface bound lectin
      molecules as determined with a hemocyanin marker. Transformed cells growing in
      monolayer cultures were found to have many more microvilli than the corresponding
      normal cells. However, when cells were brought into suspension with EDTA, all
      cells developed numerous microvilli and we were not able to distinguish between
      agglutinable and nonagglutinable cells on the basis of morphological appearance.
      Cells agglutinated by Concanavalin A had numerous interdigitated microvilli at
      points of cell-cell contact. The appearance of spontaneously agglutinated cells
      and lectin agglutinated cells was very similar with respect to the involvement of
      microvilli in cell-cell attachments, and labeling studies with hemocyanin
      indicated that Concanavalin A bound to microvilli is rapidly cleared from these
      surface specializations in a manner analogous to that observed with patching of
      surface bound lectin. Several lines of SV-40 transformed fibroblasts were shown
      to be considerably more spontaneously agglutinable than untransformed cells.
      These results indicate that Concanavalin A may amplify an intrinsic membrane
      property common to many transformed cells that is expressed as an increase in the
      rate of adhesion of suspended cells. It is proposed that the membrane change
      detected by the agglutination reaction may also be involved in the loss of post
      confluence inhibition of cell division and growth of transformed cells in
      semisolid media, due to a surface interaction that allows transformed cells to
      use each other as growth substrata.

PMID- 1030805
TI  - Therapeutic relationships between DNA synthesis and repair, membrane
      differentiation, and organ-specific immunotherapy in neuroblastoma.
AB  - The mouse neuroblastoma cell system (MNB) is of interest to both neurobiologists
      and cancer researchers because of its capacity to differentiate, with the
      consequent loss of some properties classically associated with malignancy. The
      effects of chemotherapeutic agents on MNB cells are variable; in general, cell
      cycle-specific agents will frequently induce differentiation, leaving viable
      surviving cells, while cell cycle nonspecific agents are toxic to both dividing
      and nondividing MNB cells. X-rays appear intermediate in that they are toxic to
      both cell populations, but survivors tend to resemble cells treated with cell
      cycle-specific drugs. Differentiated MNB cells apparently lose their capacity to
      repair some forms of DNA damage and this loss may be associated with their
      sensitivity to DNA damaging compounds. MNB cells are also susceptible to
      immunological lysis, particularly antibody-dependent cellular cytotoxicity.
      Integration of these diverse modes of MNB cell killing is of great interest
      because of the close resemblance of this murine tumor to human cancers in which
      cell differentiation is also partially membrane-mediated an indepth study of MNB
      cell surface receptors may have general relevance in the theoretical approach to
      cancer treatment.

PMID- 1030806
TI  - Independent control of the expression of several membrane-associated antigens of
      murine leukemia cells: metabolism and response to specific antiserum.
AB  - The effect of specific antisera on the metabolic rates of thymus-leukemia (TL), H
      2a, and tumor-associated antigens of ASL-1 and RADA-1 cells, two murine leukemia
      cell lines, were determined. The metabolic half-life of each antigen was distinct
      from the others examined. The half-life of TL antigens was 18 hr; in cells
      exposed to TL antiserum, it changed to 9 hr. In RADA-1 cells, the half-life of TL
      antigens was 16 hr; in the presence of TL antiserum it became 4 hr. The half
      lives of H-2a antigens and the tumor-associated antigen were unaffected by
      specific antiserum. Somatic hybrids of ASL-1 or RADA-1 cells were formed with
      LM(TK)-cells, a thymidine kinase deficient mutant of mouse L cells. Hybrid cells
      formed TL antigens, but unlike their parental cells their half-life of
      expression, approximately 30 hr, was unaffected by TL antiserum. Hybrid cells
      failed to undergo antigenic modulation under conditions more stringent than
      required to stimulate the modulation of ASL-1 or RADA-1 cells. The hybrids formed
      the tumor-associated antigen of their murine leukemia parental cells; however,
      the metabolic rate of the tumor antigen in hybrid cells was defferent than the
      metabolic rate of the analogous antigen in parental cells. Hybrid cells formed H
      2 antigens of both parental sources, and possessed a hybrid karyotype. The half
      life of H-2 antigens, approximately 26 hr, was the same both in parental and
      hybrid cells. H-2a antiserum had no detectable effect upon the metabolism of TL
      antigens in hybrid or parental cells; nor did TL antiserum have an effect upon
      the metabolism of H-2a antigens.

PMID- 1030807
TI  - [Economic crime].
AB  - Economic crime, often also referred to as white collar crime, is one of the most
      incidious and predatory of offenses. Unlike street crime, for which there may
      well be some protection, the average citizen is completely at the mercy of the
      perpetrators of economic crimes. The concept of white collar crime was first
      identified by Edwin H. Sutherland. He dealt with the problem as a violation of
      trust involving either or both misrepresentation and duplicity. He argued for the
      use of criminal sanctions rather than civil remedies as a means of dealing with
      white collar offenses. Sutherland's views were attacked by the legal profession,
      by sociologists and criminologists and by public opinion specialists. They
      contended that an act treated in civil court is not a crime; that criminals are
      those persons who are defined as such and white collar criminals are neither so
      defined nor do they define themselves as criminals and, finally, that economic
      crime is universal. Can anyone be criminal, then, ask the critics? A number of
      studies by Clinard, Quinney, Black, Ball, Cressey, Newman and others have
      translated the interest in white collar crime into empirical terms. The last
      thirty-five years have also witnessed the elaboration and alteration of the
      theory itself. Geis' work has been particularly important in this respect. His
      "street" versus "suite" crime is a useful dichotomy. Most important, however,
      have been the monograph and papers by Herbert Edelhertz who has conceptualized
      the issues on various levels - from consumer fraud to the illegal activities of
      the multinational corporation. This article is concerned with the exposition of
      the theory and research in the field. Most significant, the paper raises serious
      doubts whether the problem of economic crime can be researched and studied; it
      raises even more difficult issues concerning the legal and sociological
      implications of economic crime and of its prevention, management and control.

PMID- 1030808
TI  - [Use of the islamic penal code and its effects on the prevention of delinquency
      (field research)].
AB  - The Authors maintain that modern countries, despite their economic and social
      development, have not been able to find a efficient way to combat crime. In fact,
      the improvement of the material conditions of human and social life is
      accompanied by a regression in moral conditions and an increase in crime. But
      Saudi-Arabia has established a system which has proved itself extremely
      efficient, both for the improvement of the moral condition of the community, and
      for the limitation of crime to a minimal level. A comparison of statistical data,
      in fact, shows that the level of criminality in Saudi-Arabia is lower than that
      of any other country in the world. This is due to the wisdom and farsightedness
      of King Abdul Aziz Al-Saud, who, to reorganize the Saudi-Arabian people and
      establish his sovereignty, adopted the divine law of the Koran, the Sharia, as
      the only law applicable to control all individual and social relationships and to
      combat crime. By means of research conducted on the basis of statistical analyses
      and of interviews with experts chosen amongst the more elderly citizens, the
      Authors lend proof to their statements. In particular, the subjects interviewed
      have provided information based on memories of their own personal experience,
      which has been used to make a comparison between the situation as it was before
      the establishment of the sovereignty (for which no statistic data are available)
      and as it is now.

PMID- 1030809
TI  - [Current problems in the use of probation with compulsory work].
AB  - In the framework of the Soviet law, probation accompanied by compulsory work
      represents an up-to-date measure of a criminal character that allows to
      rehabilitate a convicted offender without depriving him of his freedom. The
      Panfederal Institute for the study of the causes of criminal behaviour and for
      the formulation of measures for preventing it, has conducted a number of
      researches directed at clearing up some debated problems bearing on the
      implementation of the measures existing on the subject, and at collecting
      proposals of amendment. The present article deals with the assumptions and
      preconditions, of both an objective and subjective character, underlying the
      application of this juridical institute, and also tackles, by referring to some
      cases previously occurred, the problems posed by the various types of subjects.
      Special attention is devoted to the decision-making procedure followed by the
      tribunals in applying the said measures, and to the various elements on which it
      is to be based.

PMID- 1030810
TI  - [Platelets aggregation employing ADP and cephalin. Comparative tests (author's
      transl)].
AB  - The AA. have carried out researches into the results of the platelets aggregation
      test (PAT) on 375 people by use of the Born method; they have employed ADP and a
      commercial available cephalin (Thrombofax, Ortho). In the first case the
      parameters taken into consideration are: the minimum dose of ADP able to cause a
      "double wave aggregation", the slope and the maximum increase in light
      transmission; in the second case the parameters considered are: the latency
      period, the maximum speed and the maximum amplitude. The normal values, in 75
      persons, are: --6 +/- 2 X 10(-7)M (min dose wor "double wave"); --15,5 +/- 4,9
      UT/min (slope); -- 46,3 +/- 6,8 UT (max increase in light transmission);
      regarding ADP aggregation. --90 +/- 40 sec (latency period); -- 30 +/- 15 UT/min
      (max speed); -- 52 +/- 4,63 UT (max amplitude); relating to Thrombofax
      aggregation. Analyses of PAT, by parallel using both aggregating agents, have
      been made on 260 women undergoina an oestrogen-progestative therapy, on 25
      daibetic subjects and on 15 subjects undergoing an anti-aggregation oral therapy
      (Ageroplas, Serono, Roma). The AA. stress on the validity of ADP as an
      aggregation agent in routine tests, while Trombofax has revealed itself to be not
      very sensitive in all the cases with hyperaggregation. However it is to be noted
      that use of cephalin results interesting in tests made on subjects undergoing an
      anti-aggregation therapy, as the PAT parameters seen proportional to the quantity
      of the drug given to the patient, which is just the opposite of what happens with
      ADP.

PMID- 1030811
TI  - [Consideration on the King-Armstrong method and on the kinetic method for the
      measurement of the alkaline phosphatase activity in serum (author's transl)].
AB  - The comparative study of a determined time method, according to King-Armstrong,
      for the measurement of the alkaline phosphatase activity in serum and of a
      kinetic method consents us to make the following points: 1) the reagents used in
      the King-Armstrong method are easily prepared and are stable for months, with the
      sole addition of cloroform to the substrate and to the buffer to avoid the growth
      of moulds. 2) The substrate used for the kinetic method undergoes spontaneous
      Xydrolysis in acqueous solution, which makes it possible to keep it refrigerated
      for a limited number of days. Freezing at - 20 degrees C does not improve the
      situation. 3) The degree of precision within the series and between the series is
      the same for the two methods, and very good. 4) From the working point of view
      the method of "determined time" is advantageous for few samples, while the
      kinetic method becomes preferable when the number of samples goes over 20 and 30
      a day, provided that it is linked with the suitable automatic apparatus. 5) The
      results of the measurement of the enzyme activity found with the two methods on
      120 sera of normal and pathological subjects have shown good correlation,
      confirming the clinical diagnostic value of the results obtained by the kinetic
      method, which uses a transphosphorilant buffer and their congruency with those
      obtained by the classical King-Armstrong method.

PMID- 1030812
TI  - [Salmonella strains recently widespread in Italy and its sensitivity to some
      common antibiotics (author's transl)].
AB  - A study has been carried out in order to evaluate the sensitivity of a group of
      some 517 strains of salmonella identified by the Pathogenic Enterobacteria Centre
      of Central Italy in the biennium 1974-75 to various antibiotics and
      chemotherapeutic agents. As far as the average percentage of sensitivity to the
      drugs by the strains tested is concerned, the results obtained are indicative of
      a situation which may be optimistically looked upon as far as our regions are
      concerned. Some widely used drugs such as chloramphenicol, ampicillin,
      streptomycin and kanamycin showed a high percentage of activity in vitro towards
      Salmonellae with the exception of S. wien, whereas gentamicin, co-trimoxazole,
      nalidixic acid, furoxone and cephradine were more widely active, No substantial
      differences were found between strains normally present in our regions which are,
      at present, characterized by a stationary epidemiological situation (S. typhi, S.
      paratyphi B, S. enteritidis, S. typhi-murium) and sertypes which, having been
      present in Italy for a long time, appear today to have an increasing diffusion
      (S. infantis, S. newport, S blockley and S. thompson). As for the Salmonellae of
      recent appearance and diffusion in Italy (S. panama, S. agona, S. wien) a more
      resistant pattern of behaviour to various drugs was found; this was particularly
      remarkable for S. wien which is the last in order of appearance in our
      population. Finally, the probable reasons for this  difference in behaviour are
      discussed in view of our present knowledge on drug-resistance and on the role
      played by antibiotics as selective agents at an environmental level.

PMID- 1030813
TI  - [Researches on cholesterolemia "normal values" (author's transl].
AB  - The AA. have carried out a statistical analysis regarding the frequency of
      distribution of two series of laboratory data relative to blood cholesterol. The
      data were obtained by the "direct" method from two populations; healthy blood
      donors and out-patients of an INAM laboratory. The two distributions resulted to
      be heterogeneous and it was possible to identify three elementary Gaussian
      components, one of which indicates normal subjects (values between 140 and 240
      mg%). The other two components may be tentatively defined (taking into account
      the position of the three components) by separating three distinct value levels:
      less than 210 mg% (normal values); 210-270 mg% (pre-disease); larger than 270 mg%
      (pathological values).

PMID- 1030814
TI  - Production of hypercalcemia in the chick embryo by an extract of Solanum
      malacoxylon.
AB  - White Leghorn eggs were injected on the 15th day of incubation with various doses
      of an acqueous extract of Solanum malacoxylon (SME). Most of the embryos died
      after the injection of 0.2 ml but the dose of 0.1 ml was well tolerated. The
      concentration of calcium in the sera from 15-day embryos injected with 0.1 ml SME
      was determined. Three hr after the injection the concentration of calcium had
      increased significantly; this increase lasted for at least 3 hr more but had
      disappeared 12 hr after the injection. It is suggested that this hypercalcemia
      may be produced by a water-soluble analog of 1,25-(OH)2D3 the presence of which
      has been demonstrated in the SME by other authors. It is also assumed that the
      mortality produced by the higher doses may be related to the hypercalcemia.

PMID- 1030815
TI  - [Action of acetylsalicylic acid administered by different routes on the blood and
      buccal tissues of rats].
AB  - Sixty female Sprague-Dawley rats, with an average weight of 120 g, have been used
      in this study. The experimental groups received twice a day 1 ml of a 2% acetyl
      salicylic acid suspension in methyl-cellulose either per os or i.p. The control
      groups received methyl-cellulose without asprin. The blood was collected before
      any treatment and each day during the week for the purpose of counting cells. The
      experimental animals and their control were killed after 2, 4 and 8 days. A piece
      of endobuccal epithelium with its deeper tissues was cut off and frozen for
      histochemistry. The tissue sections were treated to show the basic enzymatic
      reactions of the cell. It was observed that: 1. most of the changes appear
      between the 4th and 8th day of the treatment: 2. depending on the administration
      route, certain blood cells show a peak. Microphages between the 4th and 6th day
      in injected animals. Lymphocytes at the same time, in the gavage group; 3. oral
      epithelium lesions are limited and appear lately; 4. underlying muscles are a
      constant target. The lesions are seen in both experimental groups as soon as the
      2nd day. After a week, the lesions are more numerous. They are characterized by
      enzymatic inbalances with or without macrophages. The muscular cell is a real
      target for acetyl salicylic acid.

PMID- 1030816
TI  - [Analogs and models of systemic arterial circulation].
AB  - This review article is primarily aimed at those researches using the experimental
      physiological approach and gives a survey of analogs and models of the systemic
      arterial blood flow. They are presented in increasing order of complexity in two
      sections: the "lumped" and the "distributed" parameter models. In the first
      section a brief description is given of the purely resistive, Windkessel and
      multi-element analogs with emphasis on their use in physiology for estimating
      several hemodynamic variables. The distributed parameter models, whose central
      idea is pulse wave propagation along the arterial tree, are then presented in
      five categories, using a new classification scheme. These categories are based on
      four criteria derived from the assumptions used in the formulation of the fluid
      and wall equations. The most recent non-linear models are treated in more detail
      with their common properteis as well as their particular contribution emphasized.
      In conclusion it is noted that the distributed parameter models also begin to be
      used to evaluate physiological variables in the experimental and clinical context
      and that this trend can only become more important in view of the advances made
      in the field of biomedical instrumentation.

PMID- 1030817
TI  - Subclinical trichostrongylosis in growing lambs produced by continuous larval
      dosing. The effect on performance and certain plasma constituents.
AB  - Three groups of eight-four-month-old worm-free lambs were used to investigate the
      effect of Trichostrongylus colubriformis infection on growth rate, food intake,
      and concentration of plasma constituents. Groups ALC and ALI were fed ad libitum,
      the latter being dosed daily with 2500 infective larvae for 14 weeks. Lambs in
      group PF were paired to individuals in group ALI and offered the same quantity of
      food as the infected pair consumed. Hypophosphataemia and hypoalbuminaemia
      developed in ALI at week 3 and hyperglobulinaemia was present from week 6. There
      was no significant difference in plasma calcium, protein, urea or glucose
      concentration between the three groups at any stage. No clinical signs of
      parasitism were seen in seven of eight ALI lambs and egg counts were generally
      less than 2000 epg. Worm burdens of 1500-82,900 were found at slaughter. Group
      weight gain was only 50 per cent of PF lambs which received the same digestible
      energy intake. Group ALI consumed 15-5 kg dry matter per kg gain in bodyweight
      compared with 8-6 kg/kg and 9-8 kg/kg for ALC and PF respectively. The infections
      resulted in extensive villous atrophy and flattening of the intestinal mucosa.
      Bone growth was arrested and osteoporosis present in five group ALI lambs. The
      possible use of plasma constituents, particularly phosphorus, as aids for the
      diagnosis of the early stages of trichostrongylosis in the field is assessed.

PMID- 1030818
TI  - The effects of bumetanide on renal function and blood composition in sheep.
AB  - Respones to bumetanide were studied in five ewes. During ADH infusion urine flow
      increased from less than 1-0 to approximately 11-5 cm3 min-1 within 30 min of
      intravenous injection of 0-02 mg kg-1 bumetanide and returned to approximately 2
      0 cm3 min-1 within 3 h of dosing. The diuresis was accompanied by large increases
      in sodium and chloride excretion and smaller increases in potassium and free
      hydrogen ion excretion. Bicarbonate excretion and TCH20 were reduced. Plasma
      potassium and chloride concentrations decreased slightly while arterial
      bicarbonate pH and pCO2 slightly increased. A transient increase in GFR and RPF
      was followed by a small reduction in GFR. No change in CH20 was observed after
      bumetanide injection during water diuresis. Increasing the dose of bumetanide
      over the range 0-002 to 0-20 mg kg-1 resulted in more pronounced and prolonged
      responses. The results show that bumetanide is a potent diuretic in sheep with
      its main site of action on the ascending limb of Henle's loop.

PMID- 1030819
TI  - The qualitative assessment of glycosaminoglycans in the canine intervertebral
      disc using a critical electrolyte concentration staining technique.
AB  - Through the use of a critical electrolyte concentration staining technique, the
      glycosaminoglycans (GAGs) in the nucleus pulposus region of the canine
      intervertebral disc were arbitrarily identified as "hyaluronic acid", chondroitin
      sulphate and keratan sulphate. Approximate estimates of GAG concentration could
      be qualitatively deduced by determining the appropriate GAG "ALCIANOPHILIC
      INDEX". This index was considered to be an effective qualitative adjunct to
      chemical quantitation of GAGs in the intervertebral disc.

PMID- 1030820
TI  - Pharmacokinetic interpretation of erythromycin and tylosin activity in serum
      after intravenous administration of a single dose to cows.
AB  - The distribution and elimination kinetics of erythromycin and tylosin, which are
      macrolide antibiotics, were studied in healthy cows. A single dose (12-5 mg/kg)
      of drug was administered as an intravenous bolus, and blood samples were
      collected at precisely timed intervals. The standard cylinder plate bioassay
      method using Sarcina lutea as test organism was employed to determine antibiotic
      activity in the serum. The results suggested that these drugs are distributed in
      at least two kinetically distinct body compartments. By use of established
      mathematical techniques, values were assigned to the individual rate constants
      controlling distribution between the central and peripheral compartments and to
      the rate constant  controlling overall elimination (beta) of each drug from the
      body. The calculated overall tissue to serum drug level ratios (k12/k21) after
      apparent distribution equilibrium was attained were 2-28 and 2-05 for
      erythromycin and tylosin, respectively. The half-life (mean+/-SD) of erythromycin
      was 3-16 h+/-0-44, while that of tylosin was 1-62 h+/-0-17. The total body
      clearance (ml/kg/min) values were 2-88+/-0-47 for erythromycin and 7-8+/-2-95 for
      tylosin. Analogue computer simulated curves of the antibiotic levels in the
      central and tissue compartments as wel as an elimination curve were generated.
      The tissue level of erythromycin reached a peak of 43 per cent of the dose at 67
      min. At 6 h, the percentages of the dose of erythromycin in the central and
      tissue compartments and eliminated were 6, 19 and 75, respectively. The peak
      level of tylosin in the tissue compartment (26-5 per cent of the dose) was
      present at 30 min. At 4 h, 1 and 5 per cent of the dose were contained in the
      central and peripheral compartments, respectively, while 94 per cent had been
      eliminated. This single dose study provides information which is essential for
      the design of a satisfactory dosage regimen.

PMID- 1030821
TI  - Histological development of the small intestinal mucosa in the ovine fetus.
AB  - Histological changes in the small intestine of 85 ovine fetuses were studied,
      with particular reference to the mucosa. In 24-day-old fetuses the endoderm of
      the intestine consisted of a single layer of epithelium. By the 26th day the
      epithelium was flattened and stratified. The first evidence of rudimentary villus
      formation was noted in 39-day-old fetuses. Intestinal glands were first observed
      at 56 days. Other mucosal structures were present by 101 days. At birth the
      intestinal mucosa was fully mature.

PMID- 1030822
TI  - The isolation of ovine lymphocytes and granulocytes from whole blood using
      hydroxyethylcellulose.
AB  - Sheep erythrocytes do not aggregate spontaneously but will sediment when mixed
      with a solution of hydroxyethylcellulose. The resulting leucocyte-rich
      supernatant can be used in the preparation of purified lymphocyte and granulocyte
      suspensions.

PMID- 1030823
TI  - Swine dysentery: protection of pigs by oral and parenteral immunisation with
      attenuated Treponema hyodysenteriae.
AB  - An attenuated strain of Treponema hyodysenteriae was used to immunise 18 pigs in
      three experiments. Live attenuated spirochaetes were dosed orally and injected
      intra-peritoneally, and killed spirochaetes were injected intramuscularly with
      adjuvant. The vaccinated pigs, which developed high serum agglutination titres
      against T hyodysenteriae, and 18 unvaccinated litter-mates were repeatedly
      challenged with virulent T hyodysenteriae. Nine vaccinated pigs and 16 control
      pigs developed typical swine dysentery.

PMID- 1030824
TI  - Preliminary observations on the use of the capillary flocculation test for the
      diagnosis of heartwater (Cowdria ruminantium infection).
AB  - A capillary flocculation test was developed to diagnose heartwater disease of
      ruminants. Antigen was prepared from the brains of cattle and goats highly
      infected with Cowdria ruminantium. Sera were obtained from experimentally
      infected ruminants which either recovered naturally or with the aid of
      oxytetracycline treatment. Antibodies were first detected one to two weeks after
      clinical recovery or after treatment, and persisted for periods varying between
      one and four weeks. Control sera collected from cattle (sheep) and goats in the
      Netherlands where heartwater does not occur, or from animals serologically
      positive for Anaplasma marginale or Eperythrozoon ovis infections, did not react
      to the test.

PMID- 1030825
TI  - Autorhythmometry: leads from single-sample medical check-ups toward a health
      science of time series.
AB  - Starting from the definition of health as given by the WHO, the authors emphasize
      that rhythms of biological variables should be taken into account if one is to
      arrive at a positive and individual definition of the concept of health. The
      evaluation of a single datum spot check of physiological functions does not
      permit to quantify health in dynamic terms whereas this may become possible when
      the rhythmic quality of these variables, according to a spectrum of
      characteristic frequencies, has been assessed. Rhythmometry provides for
      appropriate reference standards as regards both the population in general and the
      physical conditions of the same subject during certain spans in the (prospective)
      life history (spans selected according to consideration of risk and hence cost
      and benefit at a given age). The authors therefore stress the importance of
      rhythmometry, thanks to which the time course and other peculiarities of any
      biological phenomenon can be evaluated by obtaining serial measurements,
      objectively quantifying their characteristic features, and working out special
      models with the aid of computers. Of special interest, particularly for the
      evaluation of reference standards, is autorhythmometry (AR), to be used at least
      for certain variables. This is the method by which each subject studies himself,
      performing a certain number of measurements in the course of the day (or month or
      year) of his body temperature, blood pressure, cardiac rhythm, grip strength,
      etc. In AR, the subject takes an active part in the study of his condition of
      health and it has been shown that in the majority of cases these measurements are
      done with the utmost accuracy and precision, providing that the purpose of the
      operations to be performed has been adequately explained. The wide spread use of
      AR, during more or less extended periods in a lifetime, would permit the
      assessment of the normal situation for each individual and thus offer the
      possibility of diagnosing any disorder at its very beginning; it would thus be of
      great prophylactic value. The authors refer to the example of arterial blood
      pressure; widely different values for the normal levels can be found in the texts
      of different authors. They also show that a certain presure may be normal for a
      given subject at a certain time of day and be a sign of illness for another
      subject, or even for the same subject at a different ime. The authors suggest the
      introduction of AR in the curriculum of secondary schools and into the routine
      for outpatients and inpatients. This practice would increase the availability of
      information on public health at a lower cost. AR may be very usefully applied to
      chronotherapy: it is a well-known fact that there are rhythms of sensitivity and
      therefore rhythms of toxic as well as therapeutic effects for various drugs.
      These can be dove-tailed in such a way as to work out, for individual cases, a
      time for administration at which the therapeutic effect is at its maximum and the
      toxic one at its minimum...

PMID- 1030826
TI  - Cord blood cholesterol, triglycerides and lipoprotein electrophoresis in 124
      Italian infants.
AB  - Total cholesterol (TC), triglycerides (TG), and lipoproteins (by electrophoresis
      on agarose gel) were determined in the cord blood of 124 Italian infants (Verona
      area). The mean TC and TG values, when compared with the values reported in other
      studies, turned out to be remarkably uniform, suggesting common genetic
      determinants in the modulation of blood lipids; no sex differences were 
      observed. The TG distribution curve was skewed, overlapping the adult pattern.
      Cord blood TC and TG were not modified by the presence of perinatal factors. Both
      beta and alpha bands (on agarose gel electrophoresis) were present in  all the
      cases. The pre-beta band was clearly detectable in 90% of the cases; it was
      barely visible for TG values below 20 mg/100 ml; occasionally a discrepancy
      between the intensity of the pre-beta band and the cord blood TG was observed,
      indicating a variable lipid composition of very low density lipoproteins (VLDL).
      In 4% of the cases a small band at the origin of the electrophoretic run was
      observed, consistent with the presence of chylomicrons. In the serum of both a
      newborn infant and its mother we detected a double band migrating in the pre-beta
      region. This finding confirms the hypothesis of a familial transmission of this
      abnormality.

PMID- 1030827
TI  - Amino-oxidase and dermal connective tissue in scoliosis.
AB  - The amino-oxidase and collagen content of dermal tissue was evaluated in 10
      patients with severe idiopathic scoliosis and in a control group of 7 patients
      with poliomyelitic scoliosis, that were to undergo surgical correction of their
      skeletal deformity. A greater dermal content of neutral salt souble collagen was
      found in the patients with idiopathic scoliosis, compared with the control group.
      Statistically the difference was highly significant. Mono-amino-oxidase activity,
      however, was found to be significantly decreased in dermal extracts obtained from
      patients affected by idiopathic scoliosis in comparison with controls. The
      involvement of mono-amino-oxidase in the crosslinking of collagen and the
      possible classification of idiopathic scoliosis as a systemic disease of
      connective tissue are discussed.

PMID- 1030828
TI  - Nuclear medicine computing. Where we have been, where we are and where we are
      going.
AB  - Demand for the newest and most elaborate Nuclear Medicine equipment is at an all
      time high. Never has there been more to offer than now with such improvements as
      large field of view, high resolution, whole-body capability and so on. The
      dedicated minicomputer systems that are available to go with these latest imaging
      devices are equally impressive. Still, the headaches associated with putting
      together a full capability camera/computer system are numerous. Things just do
      not seem to go together the way they ought to. If we are to truly get the most
      value out of our new equipment, we must put tremendous work loads on our clinical
      staff by expecting them to use very awkward and poorly configured systems in
      which several complicated steps are required to to produce the finished product
      ready for the reading room. The relatively low usage factor which most clinical
      Nuclear Medicine computer systems experience is not surprising when we consider
      the ridiculous way in which these systems are configured. It is time for a little
      human engineering to be introduced into the design process. Unfortunately, this
      proliferation of equipment is wasteful of money as well as the operator's time.
      It would make more sense to consolidate the multitude of displays and controlling
      elements into a single console which would allow a single operator to perform all
      necessary data processing operations quickly and interactively.

PMID- 1030829
TI  - [Histochemical aspects of the differentiation of the gastric glands].
AB  - The Authors have studied some aspects of the differentiation of gastric mucosa,
      during the prenatal and postnatal development in man and mouse. They have
      demonstrated that in both species the first elements of glandular rudiments can
      be already recognised, owing to the richness of their mitochondrial store, as
      parietal cells, where oxireductase activities are already present. The functional
      differentiation in the membrane of such elements takes place later on: from the
      point of view of the function the parietal cell can then be considered as
      completely differentiated. Chief cells, on the contrary, define their
      morphological and functional characters starting from the fifth month of foetal
      life. At any rate, at least for the studied characters, the gland store of human
      gastric mucosa, at birth and in the adult, is exactly alike.

PMID- 1030830
TI  - Electrophoretic variants of alkaline phosphatase in normal human populations.
AB  - Polyacrylamide gel electrophoresis of sera obtained from normal individuals shows
      an incidence (33%) of double and triple bands of alkaline phosphatase in the beta
      lipoprotein zone in addition to the usual ones near beta-globulin. The
      correlation between the occurrence of a slow moving band in addition to the
      normal one, of different intensities, p+ and p++ with O and B groups has been
      further confirmed. No relationship was observed between the width or the number
      of bands with the total amount of alkaline prosphatase as determined
      biochemically.

PMID- 1030831
TI  - [Histochemical studies of the peroxidase activity of the bursa of Fabricius of
      Gallus dom.; study of the enzymatic metabolism of that immunocompetent organ
      during its development].
AB  - By means of the technique proposed by De Robertis and Grasso (1946) for the
      histochemical localization of peroxidase activity, we have shown in the
      developing chicken Bursa of Fabricius positive cells from the 12th day onwards.
      They are localized in the mesenchymal network and increase during the
      development, reaching their top level in a period between the 18th-20th day
      before hatching and the 3rd day after hatching. After the first week these cells
      decrease and disappear during the second month. Peroxidase positive cells are
      tentatively identified as eosinophilic granulocytes (pseudoeosinophilic according
      to Romanoff); their variations should express fluctuations in the pattern of
      bursal granulocytopoiesis.

PMID- 1030832
TI  - Modifications in some rat liver cell components following stimulation with
      isoprenaline (a cytospectrophotometric, microrefractometric and
      cytoelectrophoretic study).
AB  - The liver cell is a quite interesting model for the study of several
      cytophysiological problems. Proper suspensions of isolated liver cells can be
      obtained which can be conveniently studied by means of quantitative
      microtechniques. Several cytochemical and cytophysical techniques
      (cytospectrophotometry, microrefractometry, and cytoelectrophoresis) were
      employed for elucidating the effects on the stimulation of the liver cell with
      high doses of isoprenaline, an amine which is known to produce hypertrophy and
      hyperplasia in various organs with effects also at the genetic and metabolic
      level. The following data were collected during the postnatal development of rats
      up to the 70th day of life: 1) DNA content per nucleus; 2) total dry mass per
      cell; 3) cellular electrophoretic mobility in connection with the sialomucinic
      component of the membrane. The process of polyploidization of the liver cell
      (typical of this life period) was generally accelerated; in this connection, an
      early appearance of binucleate cells and subsequent significative variations in
      their incidence were observed. This fact is important as the binucleate cells
      should represent an alternative intermediate step in the polyploidization
      phenomenon. At the same time, marked, although transient, signs of cellular
      hypertrophy were detected during a rearrangement of the hepatocyte dry mass,
      where the values tended to a multimodal distribution; in particular, IPR appeared
      to favor the disappearance of cells with a lower mass to the advantage of those
      with an intermediate mass. The study of electrophoretic mobility evidenced the
      role of the sialomucinic component of the membrane in the changes occuring in the
      parenchyma: indeed, this component exhibited an increase, thus causing an
      acceleration of the mobility similar to the one observed in actively
      proliferating cell populations. Such change persists even long after the IPR
      stimulus has ended and, at any rate, beyond the immediate phase of DNA synthesis
      and the appearance of binucleate cells.

PMID- 1030833
TI  - Prevalence and distribution of schistosomiasis in Indonesia: a review.
AB  - The prevalence and distribution of schistosomiasis in Indonesia is given, with
      the emphasis on the current data. An extensive investigation was started in 1971.
      Control measures became desirable because of development schemes in and around
      the endemic areas, thus increasing the possibility of the spread of the
      infection. This investigation consisted of: a study of prevalence, distribution,
      and intensity of the infection in man and animals; clinical studies, treatment
      and follow-up; and epidemiological studies. A comparison was made between the
      results of different workers. In addition to the only known endemic area at Lake
      Lindu, another endemic area was discovered recently at Napu Valley, situated 50
      km southeast of Lake Lindu at an altitude of 1200 meters. Surveys in other areas
      gave negative results. Nine species of wild and domestic animals were found
      positive. The intermediate host was discovered in 1971 and described as
      Oncomelania hupensis lindoensis. This snail is widely distributed in the endemic
      areas.

PMID- 1030834
TI  - Schistosomiasis in Cambodia: a review.
AB  - Human schistosomiasis has been known in Cambodia only since 1968. In 1968-1970,
      many cases were detected in the provincial capital of Kratie. Infection seemed to
      be confined to the ethnic Vietnamese fishermen who inhabited raft houses (=
      floating villages) on the Mekong River at Kratie. Overall prevalence in fishermen
      of all ages was between 7 and 10%. In the children of fishermen between the ages
      of 1 to 14, the prevalence was between 14 and 22%. Transmission was apparently
      limited to floating houses stationed more or less permanently near shore and
      connected to each other in a chain. It is believed that transmission occurred
      only in the areas of still water which were created between raft and shore. The
      principal focus of schistosomiasis in Cambodia appears to be Kratie. Only a few
      cases have been detected elsewhere in the country. The parasite is undoubtedly
      identical with the Schistosoma reported from humans and dogs at Khong Island,
      Laos. However, the transmitting snail in Laos, Lithoglyphopsis aperta, has thus
      far not been reported from the Mekong River in Cambodia.

PMID- 1030835
TI  - Preliminary observations on the biology of the Indonesian strain of Schistosoma
      japonicum: animals and oncomelanid snails.
AB  - Laboratory animals and subspecies of Oncomelania hupensis were exposed to
      experimental infections with a strain of Schistosoma japonicum from the Lindu
      Valley, Central Sulawesi, Indonesia. All laboratory animals given 50 cercariae
      were suspecptible to infection with the greatest number of worms being found in
      mice followed by Wistar rats, Long Evans rats, Mongolian gerbils, wild rats,
      hamsters and guinea pigs. Rabbits and the Taiwan monkeys given larger numbers of
      cercariae were also susceptible to infections. Adult worms were found to reach
      the largest size in the rabbit and Taiwan monkeys but many worms from rats were
      immature. Eggs from the Taiwan monkey were larger than those from a dog and from
      mice. Six subspecies or geographic strains of Oncomelania hupensis were exposed
      to 3 to 5 miracidia of the Indonesia strain of Schistosoma japonicum and only
      Oncomelania hupensis lindoensis and Oncomelania upensis chiui from Taiwan were
      susceptibile and produced cercariae while Oncomelania hupesis formosana from
      Changhua, Ilan and Kaohsium countries of Taiwan as well as Oncomalania hupensis
      quadrasi from the Philippines were considered refractory to infection.

PMID- 1030836
TI  - Some aspects on the ecology and biology of Oncomelania hupensis lindoensis.
AB  - Schistosomiasis is known to be endemic in the lake Lindu area since 1937 (Brug &
      Tesch, 1937). Investigations carried out later between 1940 and 1942 (Bone et
      al., 1942) failed to find molluscan intermediate host. It was not until April
      1971 that the first specimen of Oncomelania was found (Carney et al., 1972). In
      August of the same year the first focus was discovered at Paku (Hadidjaja et al.,
      1974). Further investigations revealed 50 more foci in the lowlands surrounding
      the lake. A survey of the habitat in the Napu Valley revealed 15 more Oncomelania
      colonies (Crney et al., in prep.). The morphology studied by Davis and Carney
      (1973) showed that this snail has a close resemblence to O. h. chiui and O. h.
      quadrasi. It was given the subspecies name Oncomelania  hupensis lindoensis.
      Snail cultures maintained according to Davis' method (1971) were done in the
      laboratory of the Department of Parasitology, Faculty of Medicine, University of
      Indonesia. Diatoms and algae were given as food. Biology of the snails concerning
      the temperature, hymidity, mortality rate of the snail or survival rate and also
      the living and egg laying habits of the snails were described.

PMID- 1030837
TI  - Control of Schistosoma japonicum infection in Lindu Valley, Central Sulawesi,
      Indonesia.
AB  - In Indonesia, schistosomiasis is presently confined to two endemic areas in
      Central Sulawesi; Lindu (1,500) and Napu (5,000 inhabitants) valleys. Because of
      various development schemes now underway, it is feared that the natural balance
      which existed for many years between the parasite, the snail intermediate hosts
      and man, will be upset and will place some 70,000 people of the adjoining Palu
      and Palolo areas at risk. Measures are being taken to control and prevent the
      spread of the disease. A pilot control programme is planned for two years in the
      village of Anca in Lindu with a population of 391 and a prevalence rate of 70.5%.
      Langko village with a population of 464 and a prevalence rate of 53.7% will be
      utilized as the comparison area. Baseline data on human, malacological and animal
      reservoir hosts are being collected and control operations are anticipated to
      commence in July 1975. Measures to be applied to control schistosomiasis in the
      order of priorities are: (a) agro-engineering or modification of the environment;
      (b) environmental sanitation through the provision of adequate water supply and
      construction of latrines; (c) mollusciciding of remaining snail infested areas;
      (d) chemotherapy, and (e) health education campaign. At the end of the two-year
      control programme, the following activities will be carried out to determine the
      degree of intervention achieved; (a) human data: calculation of prevalence rates,
      incidence rates, and changes in the intensity of infection based on quantitative
      egg counts; (b) malacological data: changes in the number and extent of snail
      foci; snail density, and snail infection rates; (c) reservoir hosts: changes in
      the prevalence rates among domestic and wild animals. Calculation of reclaimed
      areas and increase in agricultural production will also be assessed together with
      the overall cost/benefit analysis of the project undertaking.

PMID- 1030838
TI  - Agro-engineering and sanitation improvement in the control of schistosomiasis
      japonica in the Philippines: a review.
AB  - Measures that would change the habitat of the snails were found to prevent its
      breeding. Among these are clearing and drainage of waterlogged areas; filling of
      depressions where filling materials are available; ponding of areas which cannot
      be drained, and improved rice culture. The degree of success in snail control
      depends to a large extent on the amount of change brought about in the habitat.
      The more radical the change, the greater the reduction in snail density. It can
      be expected that improvement in sanitation in the form of toilet construction and
      use, provision of safe water supply, building of footbridges and the control of
      stray animals will bring a further decline in the transmission of the disease.
      Studies have shown that perfect sanitation in the form of toilet construction and
      use will reduce transmission by about 75%, the other 25% being contributed by
      lower mammals. Agro-engineering control measures are presently being carried out
      intensively in 7 town of Leyte, with food assistance from the UN/FAO World Food
      Program being given to volunteer workers as incentives for them to work. Snail
      evaluation after 2 years has shown a snail reduction by 72% in the areas covered.
      It may be mentioned here that sanitation improvement, especially latrine
      construction, is an ongoing program of the Department of Health in all rural
      areas.

PMID- 1030839
TI  - A coxsackievirus type A24 epidemic conjunctivitis in Brunei.
AB  - The paper reports on a coxsackievirus type A24 epidemic of acute conjunctivitis
      in Brunei. The role of the Singapore Epidemic Conjunctivitis 1970 (coxsackievirus
      type A24) virus in the new disease syndrome variously known as the "Epidemic
      Haemorrhagic Conjunctivitis", "Picornavirus Epidemic Conjunctivitis" and "Acute
      Haemorrhagic Conjunctivitis" is again established.

PMID- 1030840
TI  - A comparison of the efficiency of the Nuclepore and Millipore filtration systems
      for detecting microfilariae.
AB  - Using Brugia pahangi or Dirofilaria immitis as the test organisms no significant
      difference could be detected between Nuclepore and Millipore filters. It was
      found that 0.7% of microfilariae passed through the Millipore and 1% through the
      Nuclepore filters. No microfilariae were lost from the Nuclepore membrane during
      the staining process.

PMID- 1030841
TI  - Hydrogen sulphide production as an aid to the identification of Vibrio
      parahaemolyticus.
AB  - In this study 18 strains of Vibrio parahaemolyticus from food and 8 from humans
      were tested for hydrogen sulphide production on various modifications of Russel's
      Triple Sugar slopes and on TSI. All strains showed a characteristic surface
      browning on RTS with Andrade's indicator. This was not seen when RTS with phenol
      red as indicator or TSI were used. Appearance of this phenomenon allows unknown
      strains to be suspected as being Vibrio parahaemolyticus.

PMID- 1030842
TI  - Leptospirosis in Malaysia: a common cause of short-term fever.
AB  - A study of 1,437 unselected febrile patients in rural Malaysia yielded a
      diagnosis of leptospirosis in 86 (6.0%). The clinical syndrome was mild to
      moderate in all cases, jaundice was observed in only 2 (2.3%) and no deaths were
      documented. The diagnosis was not clinically obvious in most cases, and it is
      apparent that many infections must be going unnoticed at present.

PMID- 1030843
TI  - Angiostrongylus malaysiensis from Tuaran, Sabah, with reference to the
      distribution of the parasite in Malaysia.
AB  - A survey of Angiostrongylus malaysiensis among wild rodent and molluscan hosts
      was made in the Tuaran Central Agricultural Research Station and within the
      vicinity of Tuaran, Sabah. Three of 19 Rattus rattus diardii, one of 2 R. exulans
      and one R. argentiventer were found naturally infected with the parasite. In this
      survey 56 of 382 molluscs comprising of Pila scutata, Achatina fulica and two
      species of land slugs, Laevicaulis alte and Microparmarion malayanus, were found
      naturally infected with the parasite. Samples of larvae from each of these
      molluscs were experimentally transferred to laboratory albino rats and adult
      worms consistent with A. malaysiensis were recovered. Comparison of the rat hosts
      and the molluscan intermediate hosts of the parasite in Peninsular Malaysia,
      Sarawak and Sabah was made, and the finding of A. malaysiensis in Tuaran is the
      first report of the parasite from Sabah. The distribution of the parasite
      throughout Malaysia is discussed. Observation on the human consumption of the
      freshwater snail, P. scutata, was made. Although the infection rate of this snail
      is low compared with other molluscan hosts examined. The importance of this
      mollusc as a potential source of human infection should not be overlooked.
      Hospital records for 1974 and 1975 were examined and clinical human
      angiostrongyliasis was rarely recorded in Sabah.

PMID- 1030844
TI  - Parasitological survey in Gorontalo North Sulawesi, Indonesia.
AB  - A survey for blood and intestinal parasites was carried out in the municipality
      of Gorontalo on the Minahasa peninsula of North Sulawesi. A total of 156 stool
      specimens were obtained from 83 males and 73  females. Trichuris trichiura,
      Ascaris lumbricoides, hookworm, unidentified dicrocoeliid-like ova and Entamoeba
      coli, in that order, were the most common intestinal parasites detected. Other
      intestinal parasites found less frequently were Entamoeba histolytica, Iodamoeba
      butschlii, Endolimax nana, Giardia lamblia, Enterobius vermicularis and
      Chilomastix mesnili. Brugia malayi microfilaremiar were detected in 6% and
      Plasmodium falciparum in less than 1% of the population sampled.

PMID- 1030845
TI  - Reactivation studies on organophosphate inhibited human cholinesterases by
      pralidoxime (P-2-AM).
AB  - There is biochemical and clinical evidence that P-2-AM (Pyridine-2-Aldoxime
      Methiodide, Pralidoxime) does not reactive human acetylcholinesterase inhibited
      by either Malathion or Malaoxon. In vitro studies using Pralidoxime iodide up to
      ten times the recommended concentrations, produced insignificant reactivation of
      cholinesterases inhibited by Malathion or Malaoxon. This was observed inspite of
      prolonged exposure of the inhibited cholinesterases to the oxime. The value of
      Pralidoxime as a reactivator of phosphorylated cholinesterases is therefore in
      doubt, and should not be used in preference to large doses of atropine and other
      supportive treatment in poisoning by organophosphate pesticides.

PMID- 1030846
TI  - Observations on the breeding habitats of Aedes aegypti (L.) in Jakarta,
      Indonesia.
AB  - A one-year study was done of the breeding habitats of Aedes aegypti (L.) and of
      the water storage habits of the inhabitants in four crowded districts of urban
      Jakarta. Immature mosquitoes were found in or near houses in containers of
      relatively clean water used for drinking or bathing purposes. An average of 185
      containers were found per 100 houses, of which 60 were positive for Aedes
      immatures, resulting in a Container Index of 32%. The mean potential water
      storage capacity per house was 173 liters of which only 92 liters of water was
      actually being stored at any one time. Water jars were the most common containers
      found, but bak mandi (cuboidal or oblong concrete reservoirs) held more water per
      container. Total water storage per house in bak mandi was twice that of water
      jars and ten times that of drums, which were uncommon. Ant traps and other
      miscellaneous containers were unimportant for either water storage or mosquito
      production. A mean of 0.93 pupae per  house was found, pupal production indoors
      being ten times than outdoors. Indoor water jars produced more pupae per house
      than all other containers combined. The infestation rate of covered containers
      was significantly higher than that of uncovered containers, perhaps because loose
      fitting lids allowed entrance of gravid females to the attractive darkened
      interior of the container.

PMID- 1030847
TI  - Endemic goitre in Sarawak, Malaysia: I. Somatic growth and aetiology.
AB  - A comparative epidemiological and anthropometric survey was conducted among
      Ibans, the largest indigenous ethnic group in Sarawak, in three regions where the
      endemicity of goitre exhibited marked differences , to assess the effect of
      endemic goitre on somatic growth. In the Ai river region the prevalence of goitre
      was 99.5%; 35% having grade 3 goitres, 55% grade 2 goitres and 9.5% grade 1
      goitres. At Rubu the prevalence of endemic goitre was 74%; 3% having grade 3
      goitre, 16% grade 2 goitre and 55% grade 1 goitre. In the Bajong region
      relatively few people were detected with goitre and most of these had migrated
      from other regions. Neurological cretinism was estimated at 3.6% in the severely
      goitrous Ai river population but was not detected in the other regions.
      Anthropometric data obtained from the three adult populations did not reveal any
      statistically significant differences in the following parameters: weight,
      height, weight/height ratio, height/sitting height ratios, head circumference,
      scapular skinfold thickness and left mid arm muscle circumference. The
      haemoglobin, serum total protein and serum albumin concentrations were similar in
      the three populations. It is concluded that endemic goitre occurs with  a
      frequency of close to 100% in certain Iban populations which represents one of
      the highest incidences of endemic goitre in the world. Neurological cretinism is
      common in this population. Our observations suggest that body proportions and
      somatic growth do not vary among similar ethnic populations exhibiting greatly
      different endemicity of goitre. Although no iodine balance studies were
      performed, assessment of diets suggested that iodine deficiency is a significant
      contributory factor in the development of endemic goitre in Sarawak. Urgent
      attention to iodine supplementation is indicated to prevent the development of
      endemic goitre and neurological cretinism.

PMID- 1030848
TI  - Comparative growth of Malay, Chinese and Indian school children in Malaysia.
AB  - The weights and heights of 3,312 Malaysian primary school boys and girls, aged 6
      to 11 years, belonging to various ethnic groups in Malaysia were measured. On the
      whole, the Chinese children were taller and heavier than the Malay and the Indian
      children who were the least heavy among the three ethnic groups. Economically the
      Indians were the poorest among the three ethnic groups and they also had the
      largest family size. When the household incomes were taken into consideration it
      was found that the growth achievement of the higher income children was better
      than that of the poorer children, irrespective of their ethnic groups. It is
      interesting to note that, although the Indian children as a whole, were the least
      heavy of the three ethnic groups, yet the growth achievement of the higher income
      Indian children was similar to that of the higher income Chinese children. The
      differences in growth achievement of the various ethnic groups are probably due
      to environmental differences, rather than genetic differences. It seems likely
      that Malaysian children of different ethnic groups (Malay, Chinese and Indian)
      can attain similar statures if environmental conditions are similar.

PMID- 1030849
TI  - Carcinoma of the cystic duct associated with opisthorchiasis.
AB  - Four patients who had obstructing carcinoma of the cystic duct and who presented
      themselves with enlarged and palpable gall bladders but without jaundice are
      reported. All patients came from endemic areas of opisthorchiasis and had
      evidence of Opisthorchis infection by peritoneoscopic and surgical findings. All
      but one had Opisthorchis eggs in the stool. The pathogenesis and management was
      discussed.

PMID- 1030850
TI  - Intestinal and blood parasites of man in Bireuen and Takengon, Aceh Province,
      Sumatra, Indonesia.
AB  - A survey for blood and intestinal parasites was carried out in Aceh Province of
      North Sumatra, Indonesia. A total of 348 stool specimens were obtained from 167
      males and 181 females ranging in age from 6 months to 70 years. Over 98% of the
      population sampled were found infected with at least one intestinal parasite.
      Ascaris lumbricoides, Trichuris trichiura, hookworm and Entamoeba coli, in that
      order, were the most common parasites detected. Other intestinal parasites found
      less frequently were Entamoeba histolytica, Iodamoeba butschlii, Entamoeba
      hartmanni, Endolimax nana and Giardia lamblia, Brugia malayi microfilaraemias
      were detected in 2% of those examined and only in the coastal villages of Cot
      Ketapang and Rusip Dayah. No malaria was found.

PMID- 1030851
TI  - Prevalence and zoonotic potential of Ancylostoma ceylanicum in cats in Thailand.
AB  - Ancylostoma ceylanicum and Ancylostoma caninum were found in cats from Prachin
      Buri, Thailand, with infection rates of 92% and 23%, respectively. In this
      survey, 75% of cats were infected with A. ceylanicum alone, the rest had mixed
      infections of A. ceylanicum and A. caninum. The worm burden range in 26 cats for
      A. ceylanicum and A. caninum were 1 to 83 and 1 to 10, respectively. For A.
      ceylanicum, both males and females were found in the gut from the first part of
      duodenum to rectum. In the case of A. caninum the distribution was not constant.
      The sex ratio between male and female A. ceylanicum was 1:1.4. The egg count for
      A. ceylanicum was in the range 31-150 per gram of faeces (mean 70). The zoonotic
      potential of these parasites was discussed.

PMID- 1030852
TI  - Pralidoxime as an insignificant reactivator in severe anticholinesterase
      (organophosphate insecticide) poisoning.
AB  - In acute severe anticholinesterase poisoning by organophosphate compounds,
      pralidoxime (P-2-AM, pyridine-2-aldoxime methiodide) used in the recommended
      doses, intravenously, has not been shown to reactivate the inhibited
      cholinesterase, as evidenced both clinically and biochemically. In vitro studies
      using pralidoxime iodide up to ten times the recommended concentrations, produced
      insignificant reactivation of cholinesterases inhibited by the organophosphate
      insecticide Bidrin (di-methyl-3-hydroxyl-N, N-dimethyl-crotonamide phosphate).
      This was even so despite prolonged exposure of the inhibited cholinesterases to
      the oxime. The value of pralidoxime as a reactivator of phosphorylated
      cholinesterases is therefore in doubt, and should not be used in preference to
      large doses of atropine and other supportive treatment in poisoning by
      organophosphate insecticides.

PMID- 1030853
TI  - Chronic industrial exposure to lead in 63 subjects. I. Clinical and
      erythrokinetic findings.
AB  - Clinical, biochemical, haematological and erythrokinetic studies were performed
      on 63 adult males with prolonged lead exposure. Their most common symptoms and
      findings were abdominal pain (62%), gingival lead lines (48%), headache and/or
      dizziness (33%), muscle cramps (32%), anaemia (19%), and fatigue (18%). Colicky
      abdominal pain (27%) and gingival lead lines correlated with urinary lead
      excretion. Anaemia was mild, but more frequent in the subjects with the greatest
      urinary lead excretion. Other associated findings were: higher reticulocyte
      counts and more basophilic stippling of the RBCs, more sideroblasts and greater
      erythroid hyperplasia of the bone marrow, more reduction in 51Cr-tagged RBC
      survival time, smaller RBC mass, a more rapid plasma iron clearance, a greater
      plasma iron turnover and greater utilization of 59Fe in subjects with urinary
      lead excretion of greater than 100 microng/day in comparison with the remainder
      and normal controls. These findings suggest that minimal chronic exposure to lead
      causes an increased haemolysis with resulting increased production of
      erythrocytes.

PMID- 1030854
TI  - The vitamin B1, B2 and B6 status of school children in two resettlement areas in
      Northeast Thailand.
AB  - The vitamin B1, B2 and B6 status of school children were studied in the Khon Kaen
      resettlement and irrigation area and in the Lam-takong settlement in northease
      Thailand using the in vitro tests based on the erythrocyte transketolase,
      glutathione reductase and glutamate-oxaloacetate transaminase activities. Healthy
      school children from the Khon Kaen University School were selected as a reference
      group. The results demonstrate that the vitamin B1 status in the resettlement
      area is sufficient, but about 20% to 35% of all the children show evidence of
      vitamin B2 and B6 deficiencies. It is noticed that besides a high prevalence of
      parasitic infections and poor hygienic conditions the protein and vitamin intake
      is low and improvement of the situation is necessary.

PMID- 1030855
TI  - The changes of the hair roots in correlation to the clinical status of the
      nephrotic syndrome.
AB  - The examination of the hair roots were performed by a modified technique as
      described by Bradfield. The mean hair bulb diameter in children with overt
      nephrotic syndrome was statistically smaller than the controls. The distributions
      of hair root morphology amongst them were also statistically different from those
      of the control group. The hair roots of the children with remission or with
      questionable relapse were not different from the control group. The application
      of hair root examination, therefore may be useful in the differentiation of
      various stages of the nephrotic syndrome.

PMID- 1030856
TI  - Socio-economic, health and nutritional status of the villagers in the Nong Wai
      irrigation area, Khon Kaen, Northeast Thailand.
AB  - Studies were carried out from June 1974 to May 1975 on the socio-economic status,
      health and nutritional status of the people in 4 villages, in the irrigation area
      of the Nong Wai Pioneer Agricultural Project of Khon Kaen Province, Northeast
      Thailand. The result obtained were compared with those in 2 non-irrigated
      villages in the same province, in order to identify the health and nutritional
      problems which might arise during the water resource development in the
      irrigation area. It was found that in the irrigated villages 90% of the peoples
      were farmers, while in the non-irrigated villages all were farmers. The socio
      economic status of the people in the irrigated villages was much better than
      those in the non-irrigated ones. The income per family in the former was about
      three times greater than that in the latter. In the study of the health
      conditions of the villagers, the vulnerable age group including pre-school
      children under 7 years of age and school children in the elementary school class
      1 and class 2, aged 7-9 years old, served as subjects for investigation.
      Haematological and physical examinations revealed many children with mild to
      moderate anaemia, vitamin B2 deficiency and a few cases of hepatomegaly. Anaemic
      children were found to be more prevalent in the non-irrigated villages than in
      the irrigated area. The overall parasitic infection rates in children in the
      irrigated and non-irrigated villages were similar with respect to severity of the
      infection. Hookworm infection, opisthorchiasis, strongyloidiasis and giardiasis
      were the leading parasitic infections, while amoebiasis was rare. Ascariasis and
      trichuriasis were not found. However, the first two helminthic infections had a
      low grade of intensity. The nutritional status of pre-school children, showed
      that there were more children with good growth in the irrigated villages than in
      the non-irrigated one. Serum proteins, albumin and globulin, and urinary urea
      nitrogen-creatinine ratio revealed normal findings indicating that the children
      had sufficient protein intake. The results of the urinary hydroxyproline
      creatinine index suggested that many of the children in both groups of the
      villages were at marginal malnutrition status. Surveys on domestic animals
      including cattle, buffaloes, pigs, and field rats revealed no important zoonotic
      diseases except leptospirosis in a few rats. Some fish were found to harbour
      metacercariae of Opisthorchis viverrini, while some snails were positive for
      cercariae of O. viverrini, Schistosoma spindale, and Echinostoma malayanum. The
      overall findings indicated that the water resource development by establishing
      better irrigation, resulted in an improved socio-economic and nutritional status
      among the villagers, but health conditions and associated parasitic diseases and
      some nutritional deficiency still existed in the children. However, the findings
      from this study provide only preliminary data concerning the socio-economic
      status, health, and nutritional status of the villagers in the irrigation area...

PMID- 1030857
TI  - [Obtaining mutations with cytoplasmic male sterility (CMS) in Dactylis glomerata
      L. under the influence of chemical mutagens].
AB  - When treating seeds of orchard grass with definite concentrations of
      nitrosoethylurea (NEU), dimethyl sulphate (DMS) and ethylene imine (EI) in M1 and
      M2 the plants with CMS as well as sterility fixators to them are obtained.
      Proportionality of mutagenic action and stimulation effect of these substances
      are found. The greatest amount of sterility fixators is found in M1 among plants
      the seeds of which were treated with NEU and EI; in M2 the fixators are found
      among plants obtained after treating seeds with DMS. Sterility fixators were
      found among plants of the VIK-61 and Asta and VIK-61XAsta hybrid population.

PMID- 1030858
TI  - [Molecular organization of the barley (Hordeum vulgare) genome].
AB  - Studies in peculiarities of the DNA secondary structure in barley by means of
      thermal denaturation and renaturation shows that there are three types of the
      nucleotide sequences organization in DNA. More than 95% of the genome composition
      contain distributed repetitive sequences, in one part of the concentration of the
      repetitive sequences being higher as compared to bulk of them. About 3.5% of DNA
      is enriched with A-T pairs and contains no repetitive sequences. There is no
      "unique" part in the barley genome, which is natural for animals. Slowly
      renaturation sequences repeat 4 times.

PMID- 1030859
TI  - [Aneuploids from the progeny of triploid sugar beets].
AB  - The crossing of sugar beet triploids with triploids (3x X 3x) produced 25.1 +/-
      5.16% of aneuploids, the crossing of triploids with tetraploids (3x X 4x)
      resulted in 17.7 +/- +/- 2.66% of aneuploids, and the crossing of triploids with
      diploids (3x X 2x) yielded 12.4 +/- 2.36% of aneuploids. In the combinations 3x X
      2x and 3x X 4x all the theoretically possible forms of aneuploids were observed.
      After free pollination of aneuploids with different numbers of chromosomes their
      progenies comprise 71.4 +/- 2.18% of euploids and 28.6 +/- 3.31% of aneuploids.

PMID- 1030860
TI  - [Receptor cells of different types and quantitative relations between them in the
      organ of smell of larval and adult specimens of acipenserid fishes].
AB  - Three types of olfactory cells: rod-like and cone-like (flagellar olfactory
      cells) and filamentous (microvillar olfactory cells), which have been described
      previously in adult Acipenseridae were found in the olfactory organ of the ten
      days larval sturgeons (Acipenser guldenstadti), sevrugas (Acipenser stellatus)
      and sterlets (Acipenser ruthenus). The flagellar olfactory receptors appeared to
      predominate in both ten-days larvae and adults of the anadromous sturgeons and
      sevrugas, while the microvillar olfactory receptors predominate in freshwater
      sterlets in ten-days larvae as well in adults. The facts obtained confirm the
      idea that the rod-like, cone-like and filamentous olfactory cells are independent
      types of olfactory receptors. The different ratios of these cells in the
      olfactory organs of anadromous and fresh-water Acipenseridae may be a result of
      their ecological adaptations.

PMID- 1030861
TI  - [Curve of labeled mitoses in different kinetic states of cell proliferation. III.
      Experiments with a mathematical model].
AB  - By means of computer simulation, the dynamic structure of labeled mitoses curve
      (LMC) has been investigated. Experiments using computer demonstrated the
      dependence of LMC form not only on the values of temporal parameters of the
      mitotic cycle, but also on the state of cell proliferation kinetics before and
      after pulse labeling. Of particular interest was a case of a temporal block of
      cell entry into the S period which has been studied in a greater detail. The
      results of modelling experiments have shown that the universally accepted graphic
      procedures for the evaluation of mean durations of S- and G2-periods (using 50%
      level of LMC) yield the satisfactory estimates only for systems with stationary
      age distribution for cells in the mitotic cycle (steady, in the strict sense, and
      exponential states of cell proliferation kinetics). The paper presents also the
      kinetic interpretation of certain abnormalities in LMC form arising from some
      peculiarities of cell population kinetics in the real biological experiment.

PMID- 1030862
TI  - [Highly permeable contacts between epithelial cells in culture].
AB  - Cultured epithelial cells producing monolayered sheets were used to study
      intercellular contacts permeable to sodium fluorescein. Cells in dense cultures
      were more capable of forming permeable junctions than cells of sparse cultures.
      In addition, the standard microelectrode technique revealed some differences in
      cellular membrane potentials in dense and sparse cultures. A possible correlation
      is discussed between intercellular contact formation and other features of cells
      depending on cell culture density.

PMID- 1030863
TI  - [The out-patient clinic for medical oncology treatment. Experience at the
      Istituto Nazionale Tumori of Milan (author's transl)].
AB  - The possibility to administer chemo-hormone- and immunotherapy on an out-patient
      basis has greatly increased because of the progress reached in the management of
      the out-patient departments. The improved knowledges on tossicological,
      pharmacodynamic and therapeutic data as well as the advent of the cyclic
      schedules determined the feasibility of medical treatments even when they are
      combined with surgical and/or radiotherapeutic modalities. To the patient, the
      possibility to be carefully and effectively treated on out-patient clinic,
      renders more acceptable, both from a psychologic and economic point of view, even
      a prolonged combined treatment. On the same time, also the Institutions have some
      advantages both on their organization (a shorter median stay in hospital and
      consequently a reduced waiting list) and for their scientific program (increased
      number of patients who can be treated according to a therapeutic program,
      possibilities to obtain statistically valuable information on the treatment
      program of a given disease and on the knowledge of its natural history). The last
      five year increasing activity of the Out-Patient Clinic for Medical Oncology
      Treatment of the Istituto Nazionale Tumori of Milan is illustrated in Text-figure
      1, while Text-figure 2 represents its actual organization; this is obviously of a
      multidisciplinary type, both on its diagnostic and therapeutic phase. Table 1
      shows the activity carried out in 1975; it is noteworthy that 2,570 patients have
      been followed, thus accounting for a total of 20,164 medical examinations and/or
      intravenous drug administrations. Table 2 presents the incidence of the different
      types of neoplasia followed in the out-patient department: the large majority was
      represented by breast cancer (40%); followed by malignant lymphomas (31.5%) and
      pediatric tumors (7.5%). During 1975, 22 therapeutic protocols have been applied,
      10 of which (table 4) required an initial hospitalization and 12 (table 5) could
      be entirely carried out in the out-patient department. As shown in Table 6 chest
      x-rays accounted for 52% and skeletal survey for 18% of the 11.906 radiological
      examinations. Table 7 shows the number of off-hand required radiological reports
      carried out for patients not geographically accessible who, in one signle day,
      could have their radiological, and medical examinations as well as their hemogram
      and treatment performed. A total 467 scintiscans have been required, 86% of which
      of the liver (table 8). The hemato-pathology unit counted out about 16,000
      hemograms with platelets (table 9). The hemograms were always performed within 1
      2 hours with immediate communication of the counts to the out-patient department.
      In order to modify clinical situations which were deteriorated because either of
      the disease or of the treatment 358 blood units were transfused.

PMID- 1030864
TI  - Carcinoma of the thyroid gland, adenoma of the adrenal cortex and peptic ulcer:
      an unreported association.
AB  - A 39-year-old man, operated on for duodenal ulcer, was found to have a papillary
      carcinoma of the thyroid, an aldosterone-producing adenoma of the adrenal cortex,
      and a recurrence of a peptic ulcer. The probable coincidental occurrence of these
      diseases in this patient is suggested. Nevertheless, careful investigation of the
      other endocrine glands in patients with endocrine tumors is recommended.

PMID- 1030865
TI  - [Results of radiotherapy in a series of 250 carcinomas of the mucosal surface of
      the cheek (author's transl)].
AB  - This paper presents the results of a retrospective clinical study of 250 cases of
      monocentric carcinoma of the mucosal surface of the cheek, i.e. all the primaries
      treated by radiotherapy at our Institute between January 1948 and December 1965.
      Neoplastic lesions found at follow-up were regarded as marginal recurrences if in
      the proximity of the treated area and as secondary tumors in other cases. From
      1948 to 1957 conventional radium therapy was the usual treatment for the primary
      tumor whereas from 1958 to 1965 cobalt teletherapy was given most frequently.
      Surgery was reserved for lymph node metastases when present on clinical
      examination. In our experience radiotherapy is effective in cancers of the
      mucosal surface of the cheek, for it checked local spread in 50.9% of cases,
      however treated and regardless of initial clinical appearance, whereas in the T1
      T2 cases the local failure rate dropped to 35.8%. The higher the T level the
      greater are the difficulties confronting radiotherapy; for more extensive lesions
      appropriate combination therapy (radiosurgical) in line with the well-defined
      rules explained in the text is useful. In our experience radiotherapy yields good
      long term results regardless of T level and even in the more unfavorable cases.
      Our study confirms the low rate of lymph spread of these carcinomas: over half of
      the patients were N0 before treatment; only 56.7% of the patients receiving
      surgical treatment on the neck had histologically positive lymph nodes; there
      were very few neck recurrences at follow-up; the presence of suspect or frankly
      metastatic nodes on clinical examination, being movable and homolateral (N1), did
      not worsen the prognosis. However, considering the techniques used for
      irradiation of the primary, some patients received a substantial dose to the
      neck; hence radiotherapy probably played its part in the low rate of neck
      metastases.

PMID- 1030866
TI  - [Effect of ultraviolet ray-irradiated autogenous blood on hematological indices
      in horses].
AB  - Comparative clinical and experimental investigations were carried out on 18
      clinically normal horses. It was found that the single transfusion of in vitro UV
      treated autogenous blood, following a previously described method, was tolerated
      well by horses and did not lead to any deviations from the normal indices. Under
      the effect of the treated blood there was an increase in the hemoglobin content,
      rise in the erythrocyte and leukocyte count with slightly expressed
      hyperleukocytosis and weak neutrophilia (simple regeneration of the blood). The
      sedimentation of erythrocytes also showed higher rates as early as the first hour
      following the autohemotransfusion, remaining at the attained level up to the
      fourth day, while on the sixth day it again came back to the initial value. The
      contents of calcium and inorganic phosphorus rose, showing a slightly expressed
      shift to the physiologic level without reaching it. The changes in the phagocytic
      activity of the blood showed that the autohemotransfusion stimulates
      phagocytosis. Along with these effects the bacteriostatic titer of the blood, as
      recorded with the use of the anthrax bacillus as early as the first hour, and
      likewise favourably affected, the highest titers being observed at the 24th and
      48th hour.

PMID- 1030867
TI  - [Experiments in the diagnosis and therapy of stylesiasis in sheep].
AB  - Tested were several methods for the diagnosis of sheep stylesiasis - the study of
      washings, successive decantation, flotation after Fuleborn and with the use of
      zinc sulfide - obtaining no favourable results. Immunobiologic methods, such as
      the skin allergic test and the complement-fixation test had no practical
      diagnostic value either. Sheep infected with S. globipunctata reacted positively
      to antigens of M. expansa, M. benedeni, and A. centripunctata. A total of 15
      anticestode agents were tested to treat stylesias-isaffected animals. Bithionol
      and lead arsenate caused the shedding of Stylesia strobilae up to 100 per cent,
      however, about 50 per cent of the scolexes with the necks, attached to the
      intestinal wall, remained intact and produced strobilae. Cyclosamide,
      dichlorophen, trichlorophen, sulphen, dibromsulphen, and sulfoxide removed the
      strobilae, but did not almost act on the scolexes and necks, which later on
      developed strobilae. Praciquantel (isochinoline-pyrazine, EMBAU, droncit-Bayer)
      at the rate of 15 mg/kg is 100 per cent effective against S. globipunctata, M.
      expansa, M. benedeni, M. automnalia, and A. centripunctata, and has been tested
      for the first time as an anticestode means against the Anoplocephalite parasites
      in sheep. It has no unpleasant odor and taste, is practically untoxic
      (therapeutic index over 20), and could be used in group treatment of sheep.

PMID- 1030868
TI  - [Effectiveness of sodium arsamilate and its effect on the immunity of hens
      experimentally infected with Borrelia anserina].
AB  - The toxicity of sodium arsanilate for chickens was determined following a six-day
      oral application. Doses higher than 0.15/kg body weight led to symptoms of
      intoxication and death, especially when the intake of water was restricted. No
      spirochetemia, clinical signs of spirochetosis, and death cases were noted in
      birds infected subcutaneously with a lethal dose of Borrelia anserina
      simultaneously treated (orally) in the course of three days with sodium
      arsanilate either in solution or in tablets rated 0.05 -0.15/kg or in the
      drinking water at 0.4--0.5/1 for four days beginning one day prior to infection.
      Symptoms of the disease were observed in the birds of the control group only. On
      the second day after the infection the effectiveness of sodium arsanilate proved
      as high as 95 per cent, and on the third day--75 percent It was found that the
      agent had a relatively short-term prophylactic action. The chickens acquired
      immunity at the simultaneous application of sodium arsanilate and a culture of
      Borrelia anserina. Sodium arsanilate was shown not to affect the building of
      postvaccinal immunity in birds in the case of Borrelia anserina infection.

PMID- 1030869
TI  - [Biochemical and cytological changes in the milk and blood of cows with
      subclinical mastitis].
AB  - Some biochemical and cytological investigations were carried out with milk and
      milk serum, blood and blood serum of 87 cows, of which 57 manifested symptoms of
      subclinical mastitis and 25 were normal. It was established that the milk of
      animals having subclinical mastitis had lower content of lactose, inorganic
      phosphorus, and sialic acids; on the other hand chlorides were at a higher level,
      and the activity of alkaline phosphatase rose. Besides, the contents of serum
      albumin and gamma-lactoglobulins showed dependable rise, while those of alpha
      lactoglobulin and beta-lactoglobulin dropped. Dependable was likewise the drop of
      the total protein level. However, no changes were found in the total protein
      content and the distribution of protein fractions in the blood serum of cows
      manifesting inflammation of the udder.

PMID- 1030870
TI  - [Experience in controlling the Salmonella carrier state on a pedigree poultry
      breeding farm].
AB  - Systematic microbiologic control was carried out in the 1972-1975 period on an
      elite poultry farm whereas from the 23,724 samples studied, taken from objects of
      the epizootic chain forage-birds-hatchery, 78 cultures of Salmonella organisms of
      14 species or 0.32 per cent of the total number of samples were isolated. A trend
      was observed toward the year-to-year drop in the number of positive findings of
      Salmonellae, and by the end of 1975 the results were negative. This fact was
      backed by the investigations in the poultry dressing combines throughout the
      country that have received the parental forms of birds from the sanated elite
      poultry farm. Established was vertical (congenital) transmission of Salmonella
      enteritidis, and using the typhoid-pullorosis test all carrier birds were
      detected and eliminated. Thus serologically were followed up and eliminated the
      hidden sources of infection among the flocks on the elite poultry farm. The
      alimentary mechanism of infection transmission (horizontally with the chain
      forage-birds was discontinued through the storage of feed mixtures packed in bags
      (not in bulk). The chain birds-hatchery was interrupted by means of fumigation,
      the eggs being treated up to the second hour following laying, and then subjected
      to four subsequent treatment with disinfectants up to hatching. The environment
      was sanated by three-fold disinfections every sixth day with lysol, formalin or
      veraform, anf fumigation with formaldehyde vapours, resulting in 100 per cent
      effectiveness. This was demonstrated many times bacteriologically. The overall
      observation of hygiene measures contributed to the sanation of the elite farm.
      The parallel examination of personnel on the farm made by organs of the Hygiene
      and Epidemiologic Inspection detected a female worker that acted as a carrier of
      S. enteritidis. Upon her elimination the complex of measures for the study and
      complete sanation of the farm was considered fulfilled.

PMID- 1030871
TI  - [Carbamide phosphate in sheep feeding].
AB  - Experiments were carried out in 1975 with feeding urea-phosphate to year-old
      sheep of the Black face Plevenska breed in the course of three months. Results
      showed that giving urea-phosphate instead of urea produces a favourable effect on
      the digestibility of nutrient matter, the coefficient of digestibility of the
      test group sheep rising as follows: for fats--11.12 at p less than 0.001; for
      proteins--5.10 at p less than 0.01; for phosphorus--10.0 per cent (p less than
      0.01); etc. Dietary nitrogen was used 83.05 per cent (p less than 0.001) better
      when ureaphosphate was offered. A ration composed of meadow hay 1000 g, maize
      mash 300 g, barley mash 100 g, lime 5 g, sodium chloride 10 g, and urea-phosphate
      15 g influenced favorably productivity of sheep, the weight gain rising by 90 per
      cent (p less than 0.001). Mutton obtained from sheep fed urea-phosphate the rate
      of 0.4 g per kg proved of higher quality, containing more protein and less fats,
      the dressing percentage being 3.5 per cent higher.

PMID- 1030872
TI  - [Studies of the carrier state and excretion of the pathogenic plague virus in
      vaccinated swine].
AB  - Investigations were carried out on the presence of carriers and the excretion of
      the virulent swine fever virus in pigs vaccinated with the lapinized vaccine
      strain K. On the 15th, 25th, and 35th day following injection with the virulent
      virus a pig was killed each time and material was taken for morphologic studies
      and immunofluorescence microscopy. The results of the investigations were
      negative except for two pigs the cerebrum of which showed perivascular, slightly
      to moderately expressed lymphoid-cell agglomerations as well as a weakly
      manifested perivascular edema. Material of the killed animals was used to infect
      unvaccinated susceptible pigs in which the presence of the virus had not been
      demonstrated. No clinical and morphologic data or immunofluorescence microscopy
      demonstration proved the presence of a virus upon exposure of animals to pigs
      that were injected with a virulent virus. Hematologic studies revealed
      leukopenia, lower percent of hemoglobin, and a drop in the erythrocyte count
      following injection with the virulent virus. After a certain period of time this
      condition was overcome. These experiments showed that when a virulent virus gains
      access to pigs that have become immune after vaccination with the K vaccinal
      strain of the swine fever virus does not persist longer than the seventh day and
      does not cause the development of latent or a clinically manifested infectious
      process.

PMID- 1030873
TI  - [Epizootiology of leptospirosis on industrial swine-breeding complexes].
AB  - Epizoovotiologic studies were carried out at two industrial pigbreeding complexes
      for 40,000 and 33,000 animals with a record of leptospirosis. The serologic
      examination of pigs made use of the microagglutination reaction in the
      investigation of a total of 3,793 blood samples by groups corresponded to the
      technology of raising introduced at such complexes--sows, growing animals,
      replacement animals, and pigs for fattening, along with the study of 20,914 blood
      samples taken from pigs in various regions of the country. The total number of
      positively reacting pigs accounted for 12.9 per cent. Highest was the percent of
      positively reacting sows and growing pigs--19.1 and 12.9, while the replacement
      animals showed 8.31. No positively reacting animals were found among the pigs for
      fattening. Highest titers were noted among sows--up to 1:12,800 (infectious), and
      lowest among growing pigs--up to 1:100 (postnatal). State are the substantial
      economic losses caused by abortions and stillborn piglets--11 and 23 per cent,
      resp., for the two complexes. The basic Leptospira type for the two complexes and
      for the country as a whole proved L. pomona. The main source of infection were
      the carrier pigs that excreted Leptospira organisms, and the infection at the
      industrial complexes came from the hybrid sows and boars imported from abroad for
      grading purposes. A biologically justified and economically expedient programme
      of immunoprophylaxis in the control of Leptospirosis was worked out, providing
      vaccination of replacement pigs and sows only, treatment taking place after
      impregnation.

PMID- 1030874
TI  - [Study of the immunogenic properties of 3 lentogenic strains of the Newcastle
      disease virus isolated in Bulgaria].
AB  - Three local strains of lentogenic type of the Newcastle disease were used to
      produce live liquid vaccines. These were given per os to broiler chickens in
      order to test their immunogenicity (first vaccination at the age of 25 days and
      vaccination when 70 days old). The immunity thus acquired was followed
      serologically by the titer of the antihemagglutinins and the resistance
      manifested by the birds at the control infection with a proven lethal dose of a
      highly virulent velogenic strain of the Newcastle disease virus. The results
      obtained were compared with those observed with the use of liquid vaccines of the
      strains Hitchner-B1 and La Soto. It was concluded that the vaccines of the local
      Newcastle disease strains are completely harmless and immunogenic. The vaccinal
      strains are excreted by the immunized birds and serve to immunize the contact
      control chickens.

PMID- 1030875
TI  - [Methods of treating puerperal endometritis in cows].
AB  - Tested were two methods for the treatment of cows affected with acute
      endometritis after giving birth. The experiments were carried out with a total of
      92 cows of the Bulgarian Brown breed kept under equal condtions of feeding and
      management. Two tests and one control groups were formed. The first group of cows
      (48) were treated with a bilateral epipleural block after Mossin. As a result
      66.7 per cent of the cows conceived up to the 80th day after calving and 43.7 per
      cent at the first insemination. The service period of the impregnated cows of
      this group was 73.3 +/- 4.94 days, on an average. The second group of cows (25)
      were treated muscularly with a combination of 1 per cent magnesium sulphuricum
      solution (40 cu. cm), vitamin C (10 cu. cum), norsulphasol (5 g), and
      chloramphenicol (2 g). The treatment was repeated at a three-day interval. The
      results of the treatment accounted for 68 per cent impregnated cows up to an 80
      day service period, and 48 per cent--at first insemination. The service period of
      the cows of this group lasted 69.3 +/- 6.0 days, on an average. The control group
      cows were treated at random with penicillin and streptomycin, muscularly. The
      conception rate at first insemination was 36.7 per cent, and within the range of
      an 80-day service period--47.02 per cent of the treated cows. The average service
      period for this group lasted 91.80 +/- 9.28 days.

PMID- 1030876
TI  - [Comparative studies of agglutinin formation in poultry experimentally infected
      by various routes with Salm. gallinarum-pullorum].
AB  - It has been established that the immunologic response in birds is directly
      associated with the way of infection. Parenteral treatment has proved to be the
      most effective route in establishing the highest degree of titers as early as the
      6th day following injection -- 1:754. Using the intravenous route of infection
      the titers are found on the eighth day -- 1:580; at the intramuscular infection
      as well as the accomplished via subcutaneous injection the titers are observed on
      the tenth day --1:364. At oral infection the peak in the agglutination titer
      curve is noted on the twentieth day -- 1:383 (comparatively later); it has been
      found that the titers in this case remain at one and the same level for a much
      longer period of time.

PMID- 1030877
TI  - [Study of the effect of egg white and thiamine on coccidiosis in chickens caused
      by E. tenella].
AB  - Studied was the effect of tiamin at the rate of 50 mg/kg mixture and white of egg
      in ratios of 25 and 50 per cent to the feed on the course of coccidiosis in
      chickens caused by Eimeria tenella. It was found that those of the birds that
      were offered 25 per cent white of egg and tiamin in a dose of 100 mg per kg
      exhibited more severe signs of coccidiosis had more pronounced morphologic
      changes with a higher mortality rate and the amount of the oocysts shed was
      higher than the same indices in birds having received the vitamin at the rate of
      50 mg per kg and white of egg in a ration of 50 per cent to the feed. The
      increase of white of egg up to 50 per cent led to a lower oocyst production,
      however, still the latter was higher than in the control birds that were not
      given white of eggs and vitamin. Cyclicity was observed as well as explosive
      shedding of oocysts, which was associated with the physiology of the caecal
      intestines and with the biology of the parasite.

PMID- 1030878
TI  - [Study of the mechanism of erythropoietin effect on energy metabolism in the bone
      marrow].
AB  - In extracts of rabbit bone marrow cells was studied effect of erythropoietine on
      the activity of some enzymes (hexokinase, phosphoglucomutase,
      phosphohexoisomerase, lactate dehydrogenase, glucoso-6-phosphate dehydrogenase, 6
      phosphogluconate dehydrogenase and NADP-reductase). The NADP-reductase activity
      was increased under the effect of erythropoietine; the activities of other
      enzymes studied was not altered.

PMID- 1030879
TI  - [Effect of hydrocortisone acetate on carbohydrate metabolism and cellular
      respiration of lymphoma NK/ly].
AB  - Hydrocortisone acetate caused the inhibition of the limphoma cells growing. In
      the process the aerobic glycolysis was increased, the respiratory activity was
      altered slightly but the magnitude of Crebtry effect was distinctly decreased.
      Under effect of the hormone the activity of pentose pathway was drastically
      increased: oxidation via 6-phosphogluconate and the synthesis of phosphorylated
      carbohydrates by "non-oxidative" pathway were increased 1.7- and 7.4-fold,
      respectively. Thus, the stopping of the tumor cells development occurred with
      simultaneous activation of the pentose-phosphate pathway and energy metabolism as
      a whole.

PMID- 1030880
TI  - [Change in the activity and lactate dehydrogenase isoenzyme spectrum in rat
      lungs, liver and kidney cortex under the effect of hydrocortisone, insulin and
      hypoxia].
AB  - Pretreatment of rats with hydrocortisone or protamin-Zn-insulin within 4 days
      altered in subsequent acute hypoxia (3 hrs, "height" 10 000 m) the isoenzyme
      spectrum of LDH in lungs, liver tissue and kidney cortex. The differences in
      alterations in the activity and content of LDH isoenzymes were observed in
      tissues with various types of metabolism.

PMID- 1030881
TI  - [Enzymatic hydrolysis and reversible binding of suberyldicholine by
      cholinesterases].
AB  - A hydrolysis of suberyldicholine and monocholic ester of suberic acid by
      butyrylcholinesterase was studied. In the region of Sopt the rates of
      suberyldicholine hydrolysis were slightly below and under S less than Sopt they
      were far in excess of the rates of acetylcholine hydrolysis. The following
      kinetic constants of hydrolysis were obtained: for suberyldicholine--Km=2.3-10(
      5)M, V=2.4 mcM/mg. min, Kss=7.2-10(-2)M; for monocholic ester of suberic acid-
      Km=7.5-10(-4)M, V=1.5 mcM/mg, min, Kss=1.2-10(-2)M (25 degrees, pH 7.5, 0.1 M
      KCl). Suberyldicholine was shown to be highly active reversible inhibitor of
      competitive--non-competitive type (Ki=2.3-10(-6)M, alpha=0.5) of
      acetylcholinesterase from human erythrocytes; the inhibitory effect of monocholic
      ester of suberic acid was distinctly lower. By biological and indirect
      biochemical methods it was found that low concentrations of suberyldicholine 10(
      5)=10(-6)M (similar to concentrations that were in an organism upon
      myorelaxation) were hydrolyzed by acetlycholinesterase with the rate,
      approximately equal to the rate of acetylcholine hydrolysis. The reversible
      binding and the enzymatic hydrolysis of suberyldicholine by acetylcholinesterase
      of tissues were likely to be the main factors that determined the effectiveness
      and prolonged blocking action of suberyldicholine on the nerve-muscle
      conductivity.

PMID- 1030882
TI  - [Enzymatic mechanisms of inhibition of peroxidative oxidation in different
      regions of rat brain].
AB  - Activities of catalase, superoxide dismutase, glutathione peroxidase were studied
      in the cortex, cerebellul and stem of rat brain. The presence of glutathione:
      dehydroascorbate reductase was observed in rat brain. The highest levels of
      catalase, superoxide dismutase and the lowest levels of glutathione peroxidase,
      glutathione: dehydroascorbate reductase were found in the stem; the level of
      glutathione peroxidase was highest in the cerebellum. The significant part (30-
      40%) of thiol containing substances was bound with proteins as mixed disulfides.
      The role of the enzymes studied in regulation of free-radical processes and of
      the content of peroxides in brain tissue is discussed.

PMID- 1030883
TI  - [Liberation of DNA from particles of CD phage of DNA-protein complex: Properties
      of DNA in the complex and the effect of formaldehyde on the complex structure].
AB  - Properties of DNA in a complex with protein, which was liberated after
      destruction of CD phage by heat treatment in solutions with low ionic strength,
      were studied. DNA in the complex did not differ from free DNA under the same
      conditions as shown by spectra of circular dichroism and by the type of melting
      during the thermic denaturation. As demonstrated by viscosimetry and gradient
      centrifugation in cesium sulfate, 1.5% formaldehyde inhibited the dissociation of
      the complex studied in a medium containing 0.15 M NaCl. In the medium with 1.5%
      of HCHO T degrees ml of DNA in the complex was distinctly higher than T degrees
      ml of free DNA under the same conditions. Electron microscopy showed that the
      complex studied comprised DNA ;molecules, associated with protein membrane in one
      or several internal sites.

PMID- 1030884
TI  - [Effect of actomyosin on blood coagulation and fibrinolysis].
AB  - An increase in the lysis of human and rat clot of euglobulin fraction of blood
      plasma was caused by an actomyosin preparation isolated from rabbit and rat
      muscle. Neither fibrinolytic nor activating properties of actomyosin were
      observed on applying of different concentration (13-0.6 mg/ml) of the protein on
      the fibrin films. No activation of 0.4% solution of pure plasminogen by
      actomyosin was observed in vitro. A decrease in fibrin clot density under the
      effect of actomyosin was indicated by thromboelastogramms of blood plasma and
      euglobulins. The phenomenon was probably determined by the physicochemical
      properties of the protein itself.

PMID- 1030885
TI  - [Zonal distribution of haptoglobin and ceruloplasmin synthesis in the liver].
AB  - Effect of hepatotoxic agents (carbon tetrachloride and dimethyl nitrosamine) on
      the rate of the haptoglobin and ceruloplasmin synthesis in liver tissue was
      studied. In impairment of hepatocytes in the central zone of liver lobes, the
      distinct decrease in content of haptoglobin was shown to occur with a
      simultaneous increase in content of ceruloplasmin in blood serum. When parenchyma
      of the central zone of liver lobes regenerated, the haptoglobin content tended to
      normalization. The data obtained suggest that the synthesis of haptoglobin and
      ceruloplasmin is carried out in different zones of liver tissue lobes:
      haptoglobin is mainly found in the central zone and ceruloplasmin -- in the
      peripheral one.

PMID- 1030886
TI  - [Activity of lactate dehydrogenase and its isoenzymes in the thrombocytes in
      different forms of cerebral circulatory disorder].
AB  - In thrombocytes of patients with ischemic and hemorrhagic insult a transformation
      in the isozyme spectrum of lactate dehydrogenase was observed without an
      alteration in the reaction rate. In this case LDH3 was decreased and LDH1 and
      LDH4 were increased. The correlation was not found between the type of insult and
      the character of the isozyme spectrum. The alterations were considered as an
      adaptive mechanism and the reflected the extent of immediate or intermediate
      effect of ischemia on thrombocytes.

PMID- 1030887
TI  - [Eznzymatic conversions of ortho-nitrophenyl organophosphorus compounds in the
      tissues of white rats].
AB  - In homogenates of rat tissues hydrolysis of O-heptyl-O-orthonitrophenylmethyl
      phosphonate, O-pentyl-O-orthonitrophenylmethyl phosphonate and O-heptyl-O
      isopentyl-O-orthonitrophenylphosphate was studied. Hydrolysis of the preparation
      was shown to be carried out mainly in liver tissue and slso in kidney and blood
      serum. The substances studied were cleaved only at the bond P-O-aryl. The
      structure of orthonitrophenyl phosphoorganic substances exhibited the distinct
      effect on Km and on the maximal rates of the enzymatic hydrolysis. In all the
      tisses studied O-heptyl-O-orthonitrophenylmethyl phosphonate was hydrolyzed with
      maximal rate.

PMID- 1030888
TI  - [Effect of early visual deprivation on the free amino acid and protein content in
      the brain formations of dogs].
AB  - 10 days old dogs were subjected to bilateral enucleation of eyeballs. When the
      dogs became 3 months old, content of free amino acids and total proteins was
      determined in tissue of brain formation of optic system (optic cortex-field 17,
      external knee body and front bigeminal bodies). locomotor and partietal regions
      of brain cortex and cerebellum. As compared with the control group, the amount of
      proteins was distinctly decreased in optic cortex and increased in external knee
      body. In all he brain formations studied content of arginine, lysine, gamma
      aminobutyric acid, cysteine (except of external knee body) and histidine (except
      of external knee body and front bigeminal bodies) was distinctly increased. The
      decrease in content of glutamic acid was observed only in front bigeminal bodies
      and aspartic acid -- in cerebellum. Glutathione was accumulated selectively in
      front bigeminal bodies and in locomotor cortex.

PMID- 1030889
TI  - [Effect of posthemorrhagic anemia on the protein makeup of the erythrocyte
      membrane].
AB  - A distinct increase in content of gamma- and beta2-globulins was shown by means
      of polyacrylamide gel disc electrophoresis in blood serum of rats with
      posthemorrhagic anemia. The increase in content of high molecular weight proteins
      and the decrease in content of low molecular proteins were observed in the stroma
      of erythrocytes on incubation of normal red blood cells in blood serum of
      animals, subjected to loss of blood and also after perfusion of erythrocytes
      through kidney of the exsanguinated animal.

PMID- 1030890
TI  - [Changes in lipid-carbohydrate metabolism of rabbits after long-term
      administration of lactose and its derivatives--glucose and galactose].
AB  - Rabbits were administered with lactose, glucose or galactose (3 g per kg of body
      weight) within three months, after which an alteration in the pattern of response
      to a sugar loading was noted. Content of cholesterol was distinctly increased in
      blood serum after administration of glucose. After administration of lactose the
      increase in content of cholesterol was less distinct. Cholesterol, kephalin and
      lecithin were markedly deposited in heart and liver after the carbohydrates
      administration. On the treatment with galactose the total content of lipids and
      triglycerides was increased in heart. If animals were loaded with lactose,
      content of triglycerides was increased in heart only.

PMID- 1030891
TI  - [Comparative study of changes in the concentration of free cholesterol and
      antioxidative activity of lipids from animal tissues].
AB  - An inverse correlation was observed between the alterations in concentration of
      free cholesterol and an antioxidative activity of lipids in several tissues and
      cells. The effect was studied in mice liver tissue on reparative regeneration
      after partial hepatectomy, in intact mice liver under the directed action on the
      system of free radical reactions of cell lipid oxidation and in a culture of Hela
      cells during various periods of cell cycle. Using as a model system the thermal
      oxidation of oleic acid methyl ester cholesterol was found to function as a
      substrate in the reactions of free-radical cooxidation and the products of
      oxidation of cholesterol were active as antioxidants. The significance of a
      system containing cholesterol and its oxidizing products is discussed in
      connection with the metabolism of cholesterol itself and in reactions, related to
      alteration in free-radical oxidation of cell lipids.

PMID- 1030892
TI  - [Non-proteolytic enzymes of human gastric and duodenal mucosa in peptic ulcer].
AB  - Gastric and duodenal ulcers were characterized by the high activity of alkaline
      phosphatase within the zone of impairment. In gastric ulcer the high
      concentration of the enzyme was observed also in the region of minor curvature.
      Activities of aspartate and alanine transaminases were decreased in the zone of
      gastric ulcer; in duodenal ulcer only the alanine transaminase activity was
      decreased. The total lactate dehydrogenase activity was unaltered in gastric
      ulcer, but it was increased in impaired duodenum, where, among the other LDH
      isozymes, LDH5 fraction was increased.

PMID- 1030893
TI  - [Hydrophobic nucleus in the primary structure of bovine prolactin].
AB  - In the primary structure of bovine prolactin a hydrophobic fragment 79-88 of the
      peptide chain was found, which participated in a maintenance of conformation of
      the hormone molecule in a solution due to hydrophobic interactions. The fragment
      contained about 50% of leucine residues, which are currently considered as
      important in determination of three-dimensional structure and biological
      functions of protein (6).

PMID- 1030894
TI  - [Comparative study of 21S RNP particles and ribosomes from the cytoplasm of the
      cells of sarcoma M-1 in vitro].
AB  - Preparations of RNP-particles from rat sarcoma M-1 were obtained by means of
      treatment with different detergents: anione - sodium deoxycholate (1%) and non
      ionic - Triton X-100 (1%). Triton X-100 caused some increase in content of the
      small ribosomal subunit and also in the content of 21 S and 7.5 S particles in
      the preparation. The latter particles as well as ribosomes were resistant to
      different detergents. 21 S RNP-particles were stable in 1 M KCl. In a cell-free
      system 21 S and 7.5 S RNP-particles lost a significant amount of labelled
      protein, which appeared partially in the ribosomes.

PMID- 1030895
TI  - [Effect of hemorrhagic shock on catecholamine metabolism in the brain].
AB  - Content of adrenaline, noradrenaline, dopamine, DOPA and normethanephrine was
      estimated by means of the hydroxyindole method in brain tissue and hypothalamic
      region of rats subjected to hemorrhagic shock (loss of 3% of blood during 20 min)
      within 15 min, 2, 24 and 72 hrs. At the first day after the hemorrhage an
      increase in content of adrenaline and a distinct decrease in content of
      noradrenaline were observed in hypothalamic region, although the biosynthesis the
      neurotransmitters was not inhibited. Then, the noradrenaline concentration was
      normalized but the content of its precursors was decreased. In brain a constant
      posthemorrhagic increase in content of dopamine and the phase alterations in
      patterns of the catecholamine metabolism were observed: an initial decrease in
      synthesis and turnover of noradrenaline followed by its increased metabolism.

PMID- 1030896
TI  - [Vitamin A esters and their hydrolysis in different organs and tissues].
AB  - Hydrolysis of retinylpalmitate and retinylacetate was studied in rat blood, liver
      tissue, intestine, testes, placenta and embryonic liver. The retinylpalmitate
      hydrolase activity was observed only in walls of small intestine and, less
      distinctly, - in liver tissue of some animals. Retinylpalmitate was hydrolyzed in
      rat liver very slowly, that was determined apparently by the metabolic
      requirements of the organism. The retinylpalmitate hydrolase activity occurred in
      dog blood after absorption of vitamin A oil solutions. This phenomenon was
      probably related to an increased secretion of pancreatic enzymes into blood after
      the loading with oils.

PMID- 1030897
TI  - [Role of structural factor in the kinetics of free-radical oxidation of lipids in
      the membranes].
AB  - Kinetics of free radical oxidation of lipids (formation of primary molecular
      products - hydroperoxides, secondary products - carbonyl substances and
      "fluorescent pigments") was studied in various membrane fragments, which were
      distinctly differentiated by their fatty acid composition. The non-enzymatic
      catalysis of lipoperoxidation in these systems was initiated by addition of Fe2+
      + ascorbic acid. The membrane fragments were isolated from microsomes and
      mitochondria of rat liver tissue, external segments of frog retina rods,
      sarcoplasmic reticulum of rabbit and carp skeletal muscles and from microsomes of
      rabbit brain. In membrane structures the free radical oxidation of lipids
      developed following the same pattern as the liquid-phase oxidation of alkenes.
      But in phospholipids of biomembranes the rate of hydroperoxides formation did not
      correlate with the level of unsaturation of their polyene acyls. The rate of
      peroxidation of unsaturated fatty acids was distinctly determined by their
      structural organization in membranes.

PMID- 1030898
TI  - [Changes in phosphorus-calcium metabolism in experimental renal insufficiency and
      after administration of dihydrotachysterol and thyrocalcitonin].
AB  - Development of experimental chronic renal insufficiency in rats was accompanied
      by an increase in concentration of residual nitrogen and phosphorus in blood and
      also by a decrease in intestinal absorption of Ca2+, however, no hypocalcemia was
      observed and the alkaline phosphatase activity was unaltered in blood serum. At
      the same time the renal insufficiency caused in some animals metastatic
      calcification of aorta and kidney, which was manifested by increased calcium
      concentration in these tissues. Administration of dihydrotachysterol increased
      the active transport of Ca2+ in rat intestine at the later steps of the
      impairment and led to development of moderate hypercalcemia and particularly to
      an increase in the degree of calcinosis of aorta and kidney. Administration of
      thyrocalcitonine did not prevent the hypercalcemia and calcinosis of internal
      tissues.

PMID- 1030899
TI  - [Readaptive mechanisms arising during diet therapy].
AB  - Results of clinical observations and special investigations characterizing
      peculiar features of readaptive mechanisms emerging under the effect of dietetic
      therapy are reported. The most favourable shifts in the metabolic status of the
      patients are shown to occur under the influence of dietetic therapy by the end of
      the 2nd and at the beginning of the 3d week of the treatment. Toward the end of
      the treatment there is seen stabilization of readaptive reactions which can be
      later regulated by a prolonged outpatient treatment.

PMID- 1030900
TI  - [Indices of intragastric pNa-graphy in dogs].
AB  - The dynamics of intragastric pNa was looked into in 6 dogs with fistulas in the
      gastric fundus by employing the method of its automatic registration on an empty
      stomach and after feeding the animals on a nutritional stimulant. The pNa
      parameters and the types of intragastric pNa-grams before feeding the animals,
      pNa changes during and after feeding them on a nutritional stimulant and with
      histamin stimulated secretion, as well as the time of the progressively
      increasing activity of the Na+ ions and the pNa curve stabilization level were
      determined.

PMID- 1030901
TI  - [Effect of the alimentary factor on the immunobiologic reactivity of children's
      bodies].
AB  - Observations covered 66 healthy six-year old children of a childrens' home. The
      actual alimentation of the children was studied according to tabulated values for
      one year and 112 apportionoments. In the rations of actual nutrition a disturbed
      correlation of proteins, fats and carbohydrates was noted. Seasonal variations of
      the salival lysozyme activity were revealed against the background of the actual
      alimentation. The lowest antimicrobial activity of the lysozyme was recorded in
      the winter and spring seasons of the year. The low lysozyme activity of the
      saliva in spring may be explained by deficiency of the animal protein in the
      ration. In winter time added to the insufficient content of the animal protein
      were features specific for the day's routine, typical of this season. An addition
      of the animal protein to the actual nutritional rations of the children, in the
      form of eggs and nonfat dry milk and a correction of the proteins, fats and
      carbohydrates proportions in the rations led to a statistically significant rise
      in the lysozyme activity in the saliva of children during all the months of
      observation.

PMID- 1030902
TI  - [Several methodologic approaches to determining the biological value of
      proteins].
AB  - By summarizing the results of their personal experimental research work and
      literature sources the authors come to the conclusion that a temporal
      determination of the free amino acids concentration in the portal vein blood of
      rats enables one to judge about the summary duration of the first two stages of
      the protein assimilation, namely about the rate of the protein digestion and that
      of the amino acids absorption. The aminogram of free amino acids in the blood of
      the portal vein shows a marked tendency toward convergence with the consumed
      protein aminogram.

PMID- 1030903
TI  - [Intensity of virus multiplication in abortive rabies].
AB  - Experiments in random-bred and BALB/c white mice inoculated intraperitoneally
      with street virus, in Syrian hamsters inoculated intramuscularly with fixed
      viruses as well as experiments reproducing abortive rabies in 99-100% in random
      bred white mice inoculated intramuscularly with fixed virus (ERA strain) showed
      that in the abortive infection the intensity of virus multiplication in the brain
      is lower than that in fatal infection, the differences being statistically
      significant. It was found out that from onset of signs of the disease interferon
      appeared to have no influence on the outcome of infection.

PMID- 1030904
TI  - [Rifadin activity in trachoma and paratrachoma].
AB  - Rifadin after a single inoculation in a dose of 100 microng/ml completely
      inhibited the development of the causative agent of trachoma in cell culture. In
      patients with trachoma (18) and paratrachoma (4) cure was achieved by topical
      application of 5% ointment. Additional administration of the drug per os did not
      produce any considerable improvement. The cure was confirmed by the results of
      clinical, biomicroscopic, cytological and histological examinations of the
      tarsoconjunctival tissue (biopsy according to indications). Repeated examinations
      of the patients were carried out for 4 years and no cases of relapse were
      observed.

PMID- 1030905
TI  - [Biological properties of strains of influenza virus that caused the epidemic of
      1974-1975].
AB  - The biological features of the strains of influenza virus isolated in the 1974
      1975 epidemic were compared with those of the strains which had circulated
      earlier. Most of the properties examined (toxicity for mice, sensitivity to gamma
      inhibitors, thermostability of hemagglutinin and neuraminidase) in strains
      isolated in 1974-1975 did not differ from those in strains of previous epidemics.
      Clear-cut differences between the new and earlier strains were found in the
      studies of their chromatographic profiles.

PMID- 1030906
TI  - [Study of the structure of bacteriophage DD7 by the small angle of dispersion x
      ray method].
AB  - The method of roentgen small angle dispersion was used for the study of the
      structure of bacteriophage DD7. According to the results, phage DD7 is a
      homogeneous icosahedral particle (with the edge of 410-415 A) with a round
      cylindrical tail (1700-1750 A in length, 110-120 A in diameter). The lineal sizes
      of the head exceed those determined by electron microscope approximately by 25%.
      The thickness of the protein coat of the phage is 25-30 A, that is, 2 times less
      than that of phages Cd and PB-2. This confirms the assumption that the lipid
      containing portion of the phage coat is eliminated by centrifugation in cesium
      chloride density gradient.

PMID- 1030907
TI  - [Splenocyte autoreactivity of mice of sensitive lines during the latent period of
      carcinogenesis induced by virus SA7(C8)].
AB  - The method of adsorption on a monolayer of embryonal fibroblasts of 51Cr-labelled
      spleen cells from CBA and C57B1/6 mice infected at birth with SA7(C8) virus was
      used to show that the cells immune to the antigens of mouse embryo fibroblasts
      accumulated in the spleen of CBA mice highly susceptible to oncogenesis induced
      by SA7(C8) virus. In the controls, splenocytes of intact CBA mice were adsorbed
      on embryonal fibroblast monolayers (the percentage of adsorption 9.8 and 4.2,
      respectively; P less than 0.05). In the spleen of C57B1/6 mice insusceptible to
      oncogenesis induced by SA7(C8) virus there was no accumulation of cell antibody
      to the antigens of embryonal fibroblasts (P greater than 0.1). The detected
      antibody caused no cytotoxic effect on embryo fibroblasts.

PMID- 1030908
TI  - [Sequential analysis and its application possibilities in clinical psychology].
AB  - This paper describes an experimental-statistical procedure widely unknown in
      psychology, which allows an efficient problem-solving in clinical research and
      practice, such as, for example, in evaluating the officiency of therapeutical
      strategies. The method dealt with is Wald's (1947) sequential analysis, which has
      been successfully applied in pharmaceutical research as well as in quality
      controls of industrial products. The characterization of this method and the
      description of its application fields are followed by an illustrative
      computational example.

PMID- 1030909
TI  - [Attempt at scientific theoretical classification of behavior therapy].
AB  - Following the discussion about the position of behavior therapy there are
      mentioned some problems of behaviorism, the connection between behavior therapy
      and learning theory and problems of etiology and treatment. The usefulness of
      known criteria (formal as well as non-formal) should be demonstrated. There are
      discussed three different positions of behavior therapy within the scientific
      disciplines.

PMID- 1030910
TI  - [Rockers: social background, attitude and personality aspects].
AB  - A group of rockers (N = 46) was tested using questionnaires by means of which
      their social background, views and attitudes to others, intelligence, performance
      motivation and further personality variables such as aggression, extraversion,
      neuroticism and rigidity were investigated. The control group comprised a sample
      population of non-rockers (N = 132) matched with the rockers as regards age and
      education. Rockers come more frequently from broken homes and families with
      financial difficulties. They display more aggression, criminality, intolerance
      and dislike of other groups and have a higher alcohol consumption. They advocate
      physical strength and violence. There are frequent changes of employment, as well
      as a high proportion of unemployment and unqualified occupations. Their
      intelligence lies below that of the average population. As regards the other
      personality variables they did not differ from the control group.

PMID- 1030911
TI  - Conflicts in ethical problems of patient education: strategies for hypertension
      control explore contractual approach.
AB  - Experiences in the training of health education interviewers for an intervention
      strategy in a study which utilized health education strategies for control of
      hypertension afforded the opportunity for examining the relationship of research
      to practice and for addressing a recurring concern of health educators in
      practice, i.e., concern over the ethics of adopting a directing role with
      patients. This concern, which results in ambivalence in presentation and extreme
      postures of authoritativeness or passivity as educators, detracts from the
      potential of a health education intervention. While not evaluated comparatively
      with other strategies as to outcome, one method of addressing this problem,
      namely explication of the contractual approach in health education, was utilized
      informally and has implications for health education interventions. This approach
      utilizes the patient as a truly active partner and sharpens the use of the
      educational diagnosis. The outcome has potential positives for patients in
      personal growth and for educators in the sharpening of skills and in more
      effective use of their resources. These observations and the ensuing discussions
      come as an unplanned output of the study from which they derived. However, a
      variety of experiences in health education lend weight to the impression that the
      concerns addressed are not atypical of universal concerns among practitioners.
      Such conclusions suggest the timeliness of testing out the approach in an
      experimental fashion in an effort to document its use as technique as well as its
      effectiveness in ultimate outcome.

PMID- 1030912
TI  - Effect of prednisolone on the glycosaminoglycan components of the regenerating
      articular cartilage.
AB  - Investigations were performed on the effect of prednisolone (0.5 mg/kg) on the
      regenerating femoral articular cartilage of the knee joint in dogs that had been
      subjected to semiarthroplasty. After 70 days of prednisolone treatment the dogs
      were killed and the regenerating articular cartilage was removed, minced, and
      dried with acetone. The acetone-dried material was used for the determination of
      galactosamine, glucosamine, uronic acid, sulphate, sialic acid and
      hydroxyproline. Prednisolone treatment elicited a quantitative increase in
      galactosamine (30.2%), uronic acid (76.2%), and sulphate (9.1%), while no
      difference was observed in sialic acid content between the treated and untreated
      groups. From the molar ratio of the measured components it appears that
      prednisolone produced an increase in chondroitin sulphate and hyaluronic acid,
      and a decrease in the keratosulphate content of cartilage. By comparing the
      values measured in the regenerating articular cartilage of control and
      prednisolone-treated dogs with the values obtained in the mature articular
      cartilage, we may conclude that prednisolone--at least as regards the
      glycosaminoglycans of the ground substance--exerts an accelerating effect on
      cartilage regeneration.

PMID- 1030913
TI  - The hypophysis of the marine teleost fish, Mugil auratus Risso.
AB  - Owing to its lack of a hypophysial stalk, the hypophysis of the marine fish,
      Mugil auratus, is of the platybasic type. Its differentiation into
      adenohypophysial and neurohypophysial regions well conforms with the situation
      already recognized in other fishes. But, although the adenohypophysis shows
      distinction into pro-, meso- and meta-adenophypophysis, the lineo-vertical
      arrangement which they assume is not of common occurrence. By contrast, the
      neurohypophysis forms the usual central nervous core, surrounded by the
      adenohypophysial regions. The acidophils constituting the pro-adenohypophysis,
      having a deep staining affinity, resemble those in the meso-adenohypophysial
      region. The acidophils of the meso-adenohypophysis occupy a small region, whereas
      their associating cyanophils occupy a larger ventral region. The meta
      adenohypophysis consists of an integral convoluted sac of epithelial amphiphilic
      cells. Such encloses the bulk of the neurohypophysis. It is remarkable that the
      neurohypophysial fibres never interdigitate among the meta-adenohypophysial
      cells, so they are more closely related in arrangement to tetrapods than to
      fishes.

PMID- 1030914
TI  - The hypothalamic neurosecretory system of the marine teleost fish, Mugil auratus
      risso.
AB  - The hypothalamic neurosecretory system of the marinefish, Mugil auratus, consists
      of two nuclei, viz., the nucleus praeopticus and the nucleus laterlis tuberis.
      Both are paired, and while those of the nucleus praeopticus are vertically
      arranged as L-shaped bodies, their strand-like counterparts in the nucleus
      lateralis tuberis extend in an antero-posterior direction. The two constituent
      bodies of the nucleus praeopticus lie on both sides of the third cerebral
      ventricle. Each is differentiated into a dorsal pars magnocellularis and a
      ventral pars parvocellularis. A nervous tract, the hypothalamo-hypophysial tract,
      extends posteriorly from each body, but it is not until after they penetrate the
      pituitary gland that they fuse into one structure, the neurohypophysis. Many
      neurosecretory granules accumulate in the neurohypophysis adjacent to the meta
      adenohypophysial region, and fewer scattered granules of varying sizes are also
      present along the hypothalamo-hypophysial tracts. Inner to these hypothalamo
      hypophysial tracts extend the two bodies of the nucleus lateralis tuberis along
      the infundibular region. Axons from this nucleus extend sideways, and as they
      merge with those adjacently disposed of the hypothalamo-hypophysial tracts, they
      enter the pituitary gland as a unified structure.

PMID- 1030915
TI  - Electron microscopic autoradiography of serotonin uptake in the ganglia of the
      fresh-water mussel (Anodonta cygneak L.).
AB  - After in vitro incubation, the uptake of labelled serotonin was investigated by
      electron microscopic autoradiography in the ganglia of fresh-water mussel
      (Anodonta cygnea L.) The labelled serotonin was primarily taken up by the axons
      of the neurons. The silver grains could always be localized over axons containing
      eccentric dense-core vesicles with a diameter of 100--200 nm. The results suggest
      (a) the possibility of the electron microscopic identification of serotonin
      containing neurons, and (b) the direct role of the eccentric dense-core vesicles
      in the storage of serotonin.

PMID- 1030916
TI  - Detection of fetal life and growth by means of ultrasonic A-scan.
AB  - The results achieved in obstetrics by the application of ultrasonic A-scan
      technique are described. By means of the method fetal life and, from the rate of
      growth of the biparietal diameter, fetal development were determined in normal
      and pathological pregnancies.

PMID- 1030917
TI  - [Brachial arteriovenous Scribner's shunt].
AB  - Brachial arteriovenous Scribner's shunts gave good results in 18 cases, including
      an 18 months old child. In none of the cases did the ligation of the distal third
      of the brachial artery cause circulatory or functional disturbances in the lower
      arm or in the fingers.

PMID- 1030918
TI  - Effect of absorbable cellulose on the renal parenchyma.
AB  - Both kidneys of 12 dogs were injured and the wounds were covered with Surgicel
      which was fixed by means of adhesive. The results were checked by visual
      inspection and histological tests. The method seems to be suitable for use in
      appropriate human cases.

PMID- 1030919
TI  - Determinantion of testosterone concentration in semen of men with normal or
      subnormal sperm counts and after vasectomy.
AB  - Semen from 58 male subjects, aged 22 to 50, was assayed on an individual basis to
      determine whether T was present in it. Of the subjects examined 23 were
      normospermic, 14 oligospermic and 9 azoospermic; 12 men had undergone vasectomy
      were also included in the study. In 39 of the subjects plasma testosterone was
      estimated. A competitive protein binding technique was employed for T assays
      while dried extracts of semen were examined by combined gas-chromatography-mass
      spectrometry and mass fragmentography. Measurable amounts of T were detected in
      all seminal specimens assayed. This was confirmed by gas chromatography-mass
      spectrometry which showed a spectrum suggestive of T. The ratio of unconjugated
      to conjugated steroid in semen was found to be approximately 1:10. Levels of
      unconjgated T were similar to those found in plasma of normally menstruating
      women. The mean seminal concentration of unconjugated T (+/-SD) in the specimens
      assayed was 0.71 ng/ml+/-0.08 for the normospermic, 0.79+/-0.14 for the
      ezoospermic, 0.69+/-0.09 for the oligospermic, but only 0.38+/-0.04 for the
      vasectomized subjects. Plasma levels for this androgen were within the range
      found in normal men of comparable age.  Significant correlation between plasma
      and seminal T concentration could not be demonstrated and there was no
      correlation between either of the above parameters and the seminal volume, the
      number, abnormal form percentage and the motility of spermatozooa in the normo-
      or oligospermic group. However, when the two groups were pooled into one,
      significant correlations were found between plasma, (but not seminal T
      concentration) and the seminal characters examined, perhaps suggesting the number
      of specimens from the groups should be increased to obtain valid data.
      Administration of human chorionic gonadotropin produced a marked plasma response
      as well as a rise of seminal T levels in 3 normospermic subjects whereas
      cyproterone acetate caused reduction of plasm T levels but had no consistent
      effect on the seminal concentration of ts steroid although the sensitivity of the
      seminal method may not have detected smaller changes at this level.

PMID- 1030920
TI  - Protein content of human seminal plasma and spermatozoa in relation to sperm
      counts.
AB  - Protein concentrations of seminal plasma and spermatozoa were estimated in human
      normospermic, oligospermic and azoospermic semens. The protein content of seminal
      plasma ranged from 20 to 60 mg per ml semen and was found to be unrelated to
      sperm counts. Suspended sediments of azoospermic specimens were found to contain
      on the average 570+/-86 microng protein per ml semen. This value is about four
      times higher than in severe oligospermic specimens (0.2 X 10(6) -6.5 X 10(6)
      cells per ml semen). It is suggested that in azoospermic disorders seminiferous
      tubules secrete abnormally high amounts of proteinacous material which cannot be
      eliminated by washings. In addition, destruction of immature cells may contribute
      to increased protein conten in these specimens. Protein determinations in washed
      spermatozoa showed a negative relationship between the amount of protein
      calculated per 10(6) cells and original sperm counts. This trend demonstrates an
      altered protein metabolism in the spermatozoa of oligospermic specimens which
      might be responsible for fertility incompetence.

PMID- 1030921
TI  - Complex of D-glyceraldehyde-3-phosphate dehydrogenase with Cu2+ ion. I. The
      apoenzyme-Cu complex.
AB  - D-Glyceraldehyde-3-phosphate dehydrogenase binds one Cu2+ ion per subunit, which
      results in the formation of a specific metal-protein complex. This complex
      exhibits a sharp absorption band around 370 nm, and a broad, small absorption
      band in the 600-700 nm region. The shape of the absorption spectrum of Cu-GAPD
      complex in the visible range depends on the anionic composition of the solution.
      The Cu-GAPD complex is stable in solutions containing phosphate or pyrophosphate
      anions, but undergoes a slow change in sulfate-, and a rapid change in chloride
      containing solutions. The Cys-149 residue of the enzyme is essential for the
      formation of the Cu-GAPD complex. The sharp absorption at 370 nm presumably
      corresponds to a charge transfer interaction between the sulfur and the metal
      ion. Similar absorption bands are shown by the Cu-complexes of papain and thiol
      alcalase enzymes. It is assumed that in addition to the reactive thiol groups an
      imidazole residue in the active site of these enzymes is also involved in the
      complex formation, and the specific Cu-GAPD Cu-papain and Cu-thiol-alcalase
      complexes contain a Cys-Cu-His chelate structure.

PMID- 1030922
TI  - Different scientifical orientations in approaching so-called schizophrenics.
AB  - The literature on the phenomenon of "schizophrenia" presents different scientific
      orientations. These are classified under five headings: biophysical,
      intrapsychic, phenomenological, behavioural and socio-cultural. This
      classification corresponds to the different contemporary professional
      orientations. However, each orientation provides only the interpretation of one
      aspect of the total phenomenon studied. Moreover, most interpretations are still
      imperfectly developed. A comprehensive transdimensional approach is a task for
      the future.

PMID- 1030923
TI  - The interaction between neuroleptic treatment and sociotherapeutic approach in
      chronic schizophrenics. Investigations with haloperidol, penfluridol and
      pimozide.
AB  - In the modern treatment of chronic schizophrenic patients two major trends can be
      outlined: sociotherapy and psychopharmacotherapy. Therefore it is an important
      question whether these two therapeutic approaches interact in a positive or a
      negative way. Selected examples of experiments about the interaction of
      haloperidol, penfluridol and pimozide with sociotherapy are given and discussed.
      It is also demonstrated that the learning capacity of the patients depends on the
      particular type of neuroleptic.

PMID- 1030924
TI  - Long-acting neuroleptics and their place in community mental health services in
      the United Kingdom: the Salford experience.
AB  - In approaching the goal of a comprehensive community service at the city of
      Salford (England), the long-acting neuroleptics seem to be an essential step
      toward a system of continuous care for schizophrenics considered vulnerable to
      relapse. The hospitalisation experience of a sample of 211 patients is measured
      on "mirror-image" basis, i.e. an equal length of time for each patient before and
      after the start of long-acting phenothiazines. The results show a very
      substantial reduction in hospital stay.

PMID- 1030925
TI  - Conjoint measurement in psychiatric research.
AB  - In order to study complex drug-patient-milieu interactions, conjoint measurement
      models can be of great help in finding out whether there are any interaction
      patterns in the data and, if so, in specifying the kind of interaction. Some
      examples are given. The possible applications as well as the limitations of this
      technique are discussed.

PMID- 1030926
TI  - [Biochemical study on the 1st case of analbuminemia in France].
AB  - A new case of analbuminemia was described as follows for a six month's old child
      of Algerian origin. The discovery of the disease was made by chance, the clinical
      signs were limited to small oedema. The serum albumin concentration was 64 mg/1
      and its immunochemical action was identical to that of normal albumin. The system
      reacted by an increase of the synthesis of globulins. For the subject, the alpha1
      antitrypsin, ceruleoplasmin, hatoglobin, alpha2-macroglobulin, transferrin,
      immunoglobulins M contents were three times higher than the standard figures. The
      analysis of the distribution of non esterified fatty acids ususally carried by
      albumin was normal. On the other hand, it was possible to show that the presence
      of free bilirubin independant from proteins could be detected for a concentration
      of 17 micronmol/l. A study of the family showed a standard repartition of albumin
      and globulins. The genetic origin observed in the symptoms was confirmed by the
      consanguinity of the parents.

PMID- 1030927
TI  - [Use of an ion exchanger as a rapid means of extraction, applied to the
      determination of urinary estrogens and pregnanediol in pregnancy, using
      colorimetry or gas chromatography].
AB  - The method described permits, after classical hydrolysis, extraction without a
      solvent of estrogens during pregnancy. It also permits estimation of pregnanediol
      which is eluted in a different fraction. Twenty estimations may be carried out in
      half a day on test samples of from 2 to 10 ml of urine. The estimation of total
      estrogen by colorimetry takes into consideration the efficiency of extraction by
      the use of a standard range treated under the same conditions. For gas
      chromatography, two internal standards are added to the urine after hydrolysis:
      these are 16,17-epiestriol and 5 beta pregnane-3 alpha, 17 alpha, 20 beta triol
      (PGTS) have respectively the same behaviour as estriol on the one hand and
      pregnanediol and pregnanetriol, on the other hand. They take into consideration
      resin extraction and chromatographic behaviour and may be used for quantitative
      estimation. The graphs of standardisation and recovery have been studied for the
      main estrogens together with pregnanediol. The various eluates were controlled by
      gas chromatography coupled to mass spectrometry.

PMID- 1030928
TI  - [Action of 4 percent sulfuric acid on various species of mycobacteria].
AB  - The action of treatment with 4 p. cent sulphuric acid for 10 minutes, was tested
      on 13 strains of mycobacteria. Rapidly growing mycobacteria, e.g. M. diernhoferi,
      M. chelonei M. abscessus, M. Fortuitum, proved much more sensitive than slowly
      growing mycobacteria, e.g. M. xenopi, M, scrofulacem, M. kansaii, M. avium, M.
      marinum, BCG, M. tuberculosis and M. Bovis. We observed the persistance of a
      certain number of viable bacteria in spite of a duration of contact of 120
      minutes, Albumin in the culture medium used presented a protective effect
      together with the high concentration in bacteria.

PMID- 1030929
TI  - [Relationship of decerebrate rigidity maintenance with muscular contraction
      permanence after spinal cord section in dogs].
AB  - The mammalian spinal cord seems to be capable of information retation in simmilar
      fashion to the cerebral cortex memory storation. The intercollicular transection
      otherwise, relieving bulbar and mesencephalic areas from cerebral and cerebelar
      influences produces tetanic contraction on antigravidity muscles due to somatory
      with stimuli originated from muscle spindle. This phenomena is very suitable to
      memory retention studies since myotatic reflex is monossinaptic, occurs in this
      case, on a simple nervous structure (the spinal cord) and can be easily
      identified and quantitified, through muscular responses. In the present work,
      decerebrate rigidity effects upon spinal cord before and after spinal section,
      was studied. Physiological parameters were recorded in order to maintain the
      experimental condition of the dogs, as close as possible to normal, Our results
      showed that thirty and forty-five minutes in time difference of decerebrate
      rigidity influence on spinal motoneurons has little effects in tetany persistance
      after spinal section. However, ninety minutes period of time between the two
      transections produces considerable increase in rigidity permanence after spinal
      cord section. The relationship of our results with differents types of memory and
      the basic mechanism involved in the response is unknown and will be the subject
      of future investigations.

PMID- 1030930
TI  - [Aortic origin of the right pulmonary artery. Review and report of two cases
      (author's transl)].
AB  - Two cases of aortic origin of the right pulmonary artery are reported. This is a
      congenital heart disease with every low incidence. To our knowledge only 62 cases
      have been previously reported. Patent ductus arteriosus is the usual associated
      anomaly. The first of our cases is associated with patent ductus arteriosus and
      pulmonary hypertension with severe pulmonary vascular bed changes; surgical
      closure was considered unadvisable. Aortic-pulmonic window is associated in the
      second case; cardiac surgery was carried out and the patient died posoperatively.
      The previously reported cases are reviewed and are compared with anatomic,
      physiopathologic, clinical, angiohemodiamic and therapeutic features of our
      cases. Congestive heart failure and inespecific left-to-right shunt clinical
      features were present early in life, mostly in the first month. Anatomic and
      funtional evaluation is only possible by cardiac catheterization and
      angiocardiography, because pulmonary hypertension appears at a very early stage
      and once fixed makes surgical treatment unadvisable.

PMID- 1030931
TI  - [Diabetes insipidus in infancy. I. Review (author's transl)].
AB  - Diabetes insipidus and its' treatment, are revised. New pathogenic concepts
      stressing the roll of osmoreceptors in its' etiological causes are explained. In
      the diagnosis, great importance is given to recently sistematized proof by Miller
      Moses. This allows, to evaluate the grade of deficiency in vasopressin as well as
      new therapeutic possibilities, using differents drugs other from the classical
      "oily" solution of vasopressin.

PMID- 1030932
TI  - [Acro-osteolysis idiopathic distal (author's transl)].
AB  - A six year old girl. With a clinical picture of acro-osteolysis idiopathic non
      familial associated with other anomalies is presented. Literature is reviewed and
      the clinical, radiologic, pathologic and etiopathogenetic features are commented,
      pointing out the diferent associated abnormalities that other authors did not
      consign: facial, anacraneal dysplasia, epiphyseal separations and dislocations of
      radius, and peroneal incurvation.

PMID- 1030933
TI  - Effects of thyroidectomy and replacement therapy on the adrenal and testis of the
      bird myna, Acridotheres tristis.
AB  - Thyroidectomy in Myna, Acridotheres tristis, increased the levels of cholesterol,
      ascorbic acid and decreased the activity of the adrenal. The size and activity of
      the testis also decreased following thyroid removal. The weight of the two glands
      and activity of testis was not affected by 0.25 mg of 1-thyroxine. The chemical
      and histological changes of the adrenal were however reversed. It is suggested
      that thyroid deficiency leads to reduced output of the trophic hormones from the
      adenohypophysis of the bird resulting in decreased size and activity of the gonad
      and of the adrenal.

PMID- 1030934
TI  - [Paraneoplasic Cushing' syndrome. Neurosecretory granules in a lymph node
      metastasis in electronic microscopy (author's transl) (proceedings)].
AB  - The authors relate a case of paraneoplasic Cushing's syndrome by mediastinal
      tumor, probably of thymic origin. All the clinical and biological signs recall
      similar cases previously related. An "ACTH-like" substance has been found by
      biological method in a lymphoide metastasis. The main interest resides in the
      anatomo-pathological findings and more especially in electronic microscopy. The
      abundance of the neurosecretory granules is a characteristic feature of the
      malignant cells observed. These granules appear to the authors identical to those
      observed in other secretory thymomas and various tumors.

PMID- 1030935
TI  - Catecholamines and the abundance of blood cells in a fresh water tropical teleost
      (Colisa fasciatus) in relation to cold-shock.
AB  - Intraperitoneal injections of epinephrine (0.05 microng/g) elicited
      characteristic changes in the abundance of circulating leucocytes at selected
      time intervals (viz., 3, 15 and 27 min. and, later, at intervals of 48 minutes up
      to 363 min. and at 12 and 24 h) post-injection in Colisa. Leucocytosis was
      evident as 15, 27 and 75 min, and tendency towards leucocytosis was observed at
      123 and 267 min.; at 3, 171, 219, 315 and 363 min. and at 12 and 24 h, the total
      leucocyte counts for the experimentals and controls were not significantly
      different. No such corresponding significant changes were observed in the
      abundance of circulating erythrocytes or thrombocytes. Leucocyte sequence
      elicited by epinephrine was also apparent in Colisa which had been exposed to a
      temperature of 2 degrees C for one minute. Pretreatment with phenoxybenzamine
      (3.0 mg/l aquarium water), an alpha-adrenergic antagonist, abolished the cold
      shock leucocytic phases, except 27 min. leucocytosis which emerged unaffected.
      Exogenous norepinephrine (2 microng/g) and isoproterenol (0.1 microng/g) failed
      to elicit any significant change in the number of circulating leucocytes,
      erythrocytes, or thrombocytes. Clearly adrenergic mechanisms are involved in the
      cold-shock leucocyte stress sequence. The results suggest alpha-activating role
      of epinephrine during the leucocyte stress syndrome in Colisa and, apparently,
      epinephrine is leucocytic.

PMID- 1030936
TI  - [Ultrastructure of the gonadal primordia of the viviparous lizard (Lacerta
      vivipara Jacquin) during the period of colonization by the germ cells].
AB  - This ultrastructural study was carried our during colonization of the gonadal
      primordia by the germ cells which reach the gonads after interstitial migration.
      During the period of colonization, the germinal epithelia have no basal membrane.
      The epithelial cells are linked together by desmosomal junctions; they contain
      many free ribosomes, some lipid droplets, few granular reticula. The Golgi
      apparatus and the agrangular reticulum are well developed and situated at the
      distal pole of the cells. The outline of the germinal epithelia is regular in
      front of the coelomic cavity. At first, the outline of the basal surface is very
      irregular because the epithelial cells put out many cytoplasmic processes. Then,
      cytoplasmic processes become more sparse and the outline of the basal surface
      more regular. The germinal epithelia do not show swellings linked with a
      merocrine type of excretory process as in the chick (Cuminge and Dubois, 1971).
      However, this does not rule out a chemotactic type attraction of the germ cells.
      The first germ cell which arrive in the gonadal areas are incorporated into the
      epithelia. Later on, the germ cells are immobilized by the mesenchymal cells of
      the gonadal primordia which prevent them from reaching the epithelia. These germ
      cells stay in the medullary area of the young gonad which contain a greater
      number of germ cells than the epithelia.

PMID- 1030937
TI  - [Quantitative studies on the regeneration of myelinated nerve fibers. II.
      Variations of the number and size of regenerating nerve fibers after localized
      crushing or total section].
AB  - 1. The number and size of myelinated nerve fibers have been determined at
      standard levels, in the nerve to medial head of right and left gastrocnemius
      muscles of 112 rats in which the left sciatic nerve had suffered an experimental
      lesion according one of the following four modalities: localized crushing, total
      section followed or not by suture and resection of a nervous segment of about 1
      cm. 2. In the nerve to medial head of right gastrocnemius muscle (contralateral
      nerve used as control), the number of myelinated fibers decreased in average to
      10% after crushing, 5% or 4% after section followed or not by suture. However, an
      increase of 6% was observed after resection. The mean values of the mean
      diameters showed a decrease of 8% after crushing and 5% after section without
      suture. This value did not seem to be affected by section followed by immediate
      suture and after resection, it increased of 11%. On the whole, male rats appeared
      to be more sensitive than female to the effects of the operation. 3. The nerves
      of 12 rats have been observed from 15 to 334 days after resection of about 1 cm
      of sciatic nerve. The 20% of the regenerating myelinated nerve fibers which have
      succeeded to cross over such a distance had a distribution which remained
      unimodal; the diameter of the large fibres did not exceed 8 micronm. 4. 34 rats
      have been sacrificed from 15 to 715 days after sciatic nerve section which was
      not followed by suture. The number of myelinated nerve fibers became normal again
      during the 4th month and reached afterwards a mean value of 130%, with very
      marked variations. The nerve fibre distribution was most frequently unimodal, but
      may came bimodal one year after the operation in certain nerves. Their mean
      diameter never exceeded 60% of the normal. 5. The nerves of 34 rats have been
      examined from 15 to 720 days after section and immediate suture. The number of
      myelinated nerve fibers returned to normal during the second month and increased
      afterwards to an average of 150% with very important variations. The nerve fiber
      distribution was generally unimodal, but may become bimodal 7 months after the
      operation. Their mean diameter reached only 50 to 55% of the normal. 6. 32 rats
      have been sacrificed from 10 to 720 rats after a localized crushing. The number
      of myelinated nerve fibers come back to normal during the 4th week and later
      increased up to a mean of 115%. Their distribution became early bimodal from the
      97th day onwards. Although, their mean diameter nerver exceeded 80% of the
      normal, the histograms of the regenerating nerve and of the control nerve could
      be almost superposed during the second year.

PMID- 1030938
TI  - Labeling of lectin receptors during the cell cycle.
AB  - Labeling of lectin receptors during the cell cycle. (Localizabion de receptores
      para lectinas durante el ciclo celular). Arch. Biol. Med. Exper. 10: 100-104,
      1976. The topographic distribution of specific cell surface receptors for
      concanavalin A and wheat germ agglutinin was studied by ultrastructural labeling
      in the course of the cell cycle. C12TSV5 cells were synchronized by double
      thymidine block or mechanical selection (shakeoff). They were labeled by means of
      lectin-peroxidase techniques while in G1 S, G2 and M phases of the cycle. The
      results obtained were similar for both lectins employed. Interphase cells (G1 S,
      G2) present a stlihtly discontinous labeling pattern that is similar to the one
      observed on unsynchronized cells of the same line. Cells in mitosis, on the
      contrary, present a highly discontinous distribution of reaction product. This
      pattern disappears after the cells enters G1 and is not present on mitotic cells
      fixed in aldehyde prior to labeling.

PMID- 1030939
TI  - In vitro degradation of ribosomes.
AB  - The cytoplasmic ribosomes from Euglena gracilis var. bacillaris are found to be
      of two types taking into consideration their stability "in vitro". In the group
      of unstable ribosomes the large subunit is degraded. The other group apparently
      does not suffer any degradation under the conditions described. However the RNAs
      extracted from both types of ribosomes are degraded during sucrose density
      gradients. The degradation of the largest RNA species has been reported
      previously, but no comment has been made about the stability of the ribosome
      itself.

PMID- 1030940
TI  - Changes in plasma membranes during the prereplicative phase of the isoproterenol
      stimulated parotid glands of mice.
AB  - A single intraperitoneal injection of isoproterenol induces resting cells from
      the acini of the mouse parotid gland to enter the proliferative cycle. Parotid
      plasma membrane from non-stimulated and isoproterenol-treated mice were prepared
      by differential centrifugation of the homogenates. Comparing the chemical
      composition of plasma membranes from non-stimulated and isoproterenol-treated
      mice, no variation in the phospholipid/protein ratio was observed. However, the
      levels of neutral sugars, hexosamines and sialic acid fall drastically in the
      early prereplicative phase. The decrease in neutral sugars and hexosamines in
      plasma membranes caused by isoproterenol is imitated by pilocarpine, which
      induces secretion but little or no increase in DNA synthesis. However,
      pilocarpine does not mobilize sialic acid from the plasma membrane. Moreover,
      dosis of isoproterenol that elicits secretion but not mitosis in the acinar
      cells, does not induce the movement of sialic acid from the plasma membrane. The
      mobilization of sialic acid from plasma membranes caused by isoproterenol was
      also demonstrated in an in vitro system. Treatment of the plasma membrane with
      chloroform/methanol shows that around 60% of the sialic acid is present in the
      less polar phase. We conclude that the separation of sialic acid from the plasma
      membrane is one of the early steps in the sequence of events leading to DNA
      synthesis and cell division in the isoproterenol-stimulated parotid gland of
      mice.

PMID- 1030941
TI  - [Study of the microcirculatory bed by a method of demonstrating lactate
      dehydrogenase].
AB  - The method of detection of lactate dehydrogenase with some modification was used
      to study the microcirculatory bed in total preparations of serous membranes and
      plane sections of organs of any square surface. The employment of non-fixed
      material, the short time (from 15 to 60 min) necessary to obtain preparations of
      any size and simultaneous determination of the localization and the degree of the
      activity of the enzyme--are, to the authors opinion, undoubtful advantages of the
      given method, which can be an addition to the well-known impregnation method of
      determination of the microcirculatory bed.

PMID- 1030942
TI  - [Tomography of the maxillary sinus].
AB  - The maxillary sinuses were studied roentgenographically and tomographically in
      108 patients (with intact sinuses) and in 16 anatomical preparations of the
      cranium. It has been established that the main features of the laminar picture of
      the maxillary sinuses can be determined by two main properties of tomography as a
      method: the possibility to lead the portions of the sinus osseous walls of
      greater-length as compared with conventional roentgenography out to the edge
      forming zone due to oblique course of the ray beam, and vise versa, disappearance
      of outlines of these walls in those sections where they are considerably inclined
      in relation to the roentgen film plane. A description of the laminar roentgen
      anatomical picture of the maxillary sinuses in naso-frontal, nasomental and
      lateral projections is presented. It is stresses that in each of these
      projections several main types of the laminar picture of the maxillary sinuses
      can be detected, characterizing different depth of sections.

PMID- 1030943
TI  - [Anatomo-topographic features of the deep lymph nodes of the neck in adult
      humans].
AB  - Profounod cervical lymph nodes were studied on 35 corpses and 30 complexes of
      organs of the head and neck in adult man by method of dissection after a
      preliminary injecting the lymphatic vessels and nodes. Under study were the lymph
      nodes of the anterior part (prelaryngeal, prethyroid, pretracheal and
      paratracheal groups) which are disposed under the pretracheal lamina of the
      cervical fascia. The lymph nodes of the lateral area of the neck are concentrated
      along the internal jugular vein, accessory nerve and the transversal artery of
      the neck. The lymph nodes disposed along the internal jugular vein are divided
      into 3 groups: superior, medial and inferior. The lymph nodes disposed in the
      lateral area of the neck are of different types. The obtained data can be used
      for decoding data of lymphography.

PMID- 1030944
TI  - [Structure of the gastric mucosa following experimental antrectomy].
AB  - The important role of the antral part of the stomach in sustaining the gastric
      mucosa tissue homeostasis has been shown in chronic experiment in dogs. In 5-13
      months after antrectomy the thickness of the gastric mucosa diminishes by 21% at
      an average, the height of the fundal glands-by 29%, the amount of the parietal
      cells-by 54%, the amount of basic cells-by 34%. Hypoplastic lesions of the
      gastric mucous membrane develop and complete within the first months after
      antrectomy. After the 5th month the degree of hypoplasia fails to markedly
      increase, i. e. the shifts found are not of constantly progressing character.

PMID- 1030945
TI  - [Arterial blood supply to the laryngeal part of the pharynx].
AB  - The sources, anastomoses and variations of bloodsupply of the laryngeal part of
      the pharynx were studied in 100 corpses of different sex and age. It has been
      established that the fronto-lateral divisions of the laryngeal part of the
      pharynx are supplied with blood by pharyngeal branches of the superior and
      inferior paryngeal arteries. Ligation of the pharyngeal arteries during
      laryngectomy prior to their entering the larynx, i. e. before the divergence of
      the pharyngeal branches from them, as conventional, causes restriction of supply
      of these parts and can contribute to disjunction of the pharyngeal suture. The
      trunks of laryngeal arteries with their pharyngeal branches should be preserved,
      if possible. The posterior wall of the laryngeal part of the pharynx is divided
      into three zones depending on the main arterial sources (the ascending
      pharyngeal, superior and inferior thyroid arteries).

PMID- 1030946
TI  - [Anatomic transformation of the lymphatic bed of the small intestine following
      immunization].
AB  - The experimental investigation of the lymphatic bed of the small intestine after
      immunization was performed in 15 rabbits. Ten rabbits were taken as control. The
      rabbits were immunized by administration of kidney antigen with the complete
      Freund adjuvant. The animals were killed on the 7-8th days after two cycles of
      immunization, three injections in each cycle. The interval between the injections
      was three days, between the cycles - one month. Polychrome injection of arteries
      and veins was made. The lymphatic bed was filled with Gerota's mass. The chylus
      sinuses, lymph capillaries and vessels of experimental animals were found to be
      dilated 2-6 times as compared with normal. There appear many blind processes on
      the walls of lymph capillaries and vessels. Intraorganic lymphatic pathways were
      more dilated as compared with extraorganic. The ileum was found to be more
      reactive in immunization than other two parts of the small intestine.

PMID- 1030947
TI  - [Linear dimensions of the lamina of the tectum mesencephali during human
      ontogenesis].
AB  - The dynamics of the establishment of linear dimensions of the lamina of tectum
      mesencephali in ontogenesis was studied in 145 preparations of human brain. The
      investigation was performed with by the M. M. Sauliak-Savitskaja apparatus
      (1953). The obtained data were processed by the method of mathematical analysis.
      The relief of the superior colliculi was found to be formed earlier than that of
      the inferior colliculi. The linear dimensions of both colliculi are practically
      equal to those of adult men during the third year of life. No correlative
      relationship between the sex of the objects under study and the linear dimensions
      of the lamina of tectum mesencephali was found as well as between thr right and
      left parts of the lamina tecti. The linear dimensions of it in all age groups are
      very variable.

PMID- 1030948
TI  - [Features of the structural organization of the dolphin (Phocaena phocaena)
      lateral geniculate body in comparison to other dolphins].
AB  - The work describes a new for dolphins type of the cytoarchitectonic organization
      and topographo-anatomical features of the dorsal nucleus of the external
      geniculate body found in the dolphin Phocaena phocaena. In dolphins only the
      alveolar type of organization of the formation in question had been known which
      was principally different from the laminar and nuclear types characteristic of
      the terrestrial mammals. The Phocaena phocaena proved to have the nuclear type of
      organization of the external geniculate body, as well as in certain mammals. In
      addition, a fact of a sharp quantitative diminution of the external geniculate
      body as compared with other dolphins has been revealed which is of interest for
      the physiology of vision. This fact is of significance showing the total amount
      of nerve cells in the dorsal nucleus of the external geniculate body of the
      Phocaena phocaena to be equal to 6,6% as compared with the white-sided dolphin.
      Since the above diminution proved to be selective and did not take place in the
      anterior tuber of the quadrigeminum, the author puts forward the idea that a
      considerably less afferentation comes to the visual cortex of the Phocaena
      phocaena than to that of other dolphins, due to some, yet unknown, restriction of
      the visual function.

PMID- 1030949
TI  - [Nuclei and fields of the rabbit hypothalamus].
AB  - Common features and distinctions in the structure of certain fields of the rabbit
      hypothalamus were established on the basis of cytoarchitectonical and cytological
      analysis. It has been shown that there are three types of nerve cells in the
      nuclei and fields of the hypothalamus which can be referred to somato-, cyto- and
      karyochromic elements of the nervous system in accordance with the Nissl
      classification. All the cellular structures of the hypothalamus can be divided
      into heteromorphic and isomorphic types. The medial and lateral hypothalamic
      fields of all the rostro-caudal length of the hypothalamus are referred to the
      first type. The hypothalamic nuclei occupying its basal part are referred to the
      second type. On the basis of the obtained data concerning the neuronal
      composition of the fields and nuclei of the hypothalamus, it can be divided into
      three zones: the medial zone, including 3 medial hypothalamic fields disposed
      along the 3d ventricle; the lateral zone comprizing two a lateral hypothalamic
      fields occupying its lateral parts along its all length and the basal zone
      including hypothalamic nuclei disposed mainly in the ventral part of the
      hypothalamus.

PMID- 1030950
TI  - Chemical structure of the peptidoglycan of Vibrio parahaemolyticus A55 with
      special reference to the extent of interpeptide cross-linking.
AB  - The chemical structure of the cell wall peptidoglycan of Vibrio parahaemolyticus
      A55 was studied. Estimation of cross linkages between peptide subunits in the
      peptidoglycan by dinitrophenylation showed that about 30% of the total 2,6
      diaminopimelic acid (A2pm) residues were involved in cross linkages. The presence
      of interpeptide bridges was also demonstrated by isolating bisdisaccharide
      peptide subunit dimers from Chalaropsis muramidase digests of the cell wall
      peptidoglycan by gel filtration followed by ion-exchange column chromatography,
      although most of the building blocks obtained were uncross-linked disaccharide
      peptide monomers. The chain length of a glycan moiety of the peptidoglycan
      obtained by treatment with the L-11 enzyme and gel filtration of the digest was
      also studied. The chain length varied from 7 to 44, but 30% of the glycan
      fragments had muramic acid at the reducing end and a chain length of 28 to 44. In
      conformity with the above structural study it was demonstrated that a particulate
      enzyme fraction obtained by differential centrifugation of a sonicated
      preparation of V. parahaemolyticus catalyzed a penicillin-sensitive
      transpeptidation reaction, using UDP-MurNAc-14C-pentapeptide and UDP-GlcNAc as
      substrates.

PMID- 1030951
TI  - [Role of gastrin in the gastric secretion of birds].

PMID- 1030952
TI  - [Influence of endogenous factors on digestive secretion induced with bombesin].

PMID- 1030953
TI  - [Electron microscopic studies of the muscle tissue of the velum of the larva of
      Lampetra planeri (Bloch)].

PMID- 1030954
TI  - [Extraembryonal erythropoiesis in organ type cultures].

PMID- 1030955
TI  - [Effects of somatostatin and sulpiride administration on prolactin secretion in
      normal adult subjects].

PMID- 1030956
TI  - [Cutaneous perception of figured tactile stimuli in humans under normal
      conditions].

PMID- 1030957
TI  - [Preliminary study of CSF levels of HVA in chronic alcoholics].

PMID- 1030958
TI  - [Variations of CSF levels of 5-HIAA in chronic alcoholism].

PMID- 1030959
TI  - [Effects of phenobarbital on ampicillin distribution in rats].

PMID- 1030960
TI  - [Metabolism of erythromycin and erythromycin aspartate in the microsomal fraction
      of the rat liver].

PMID- 1030961
TI  - [Fatty acids in mature larvae of Hydropsyche dissimulata Kum. Bot. and of H.
      pellucidula Curt. (Insecta, Trichoptera)].

PMID- 1030962
TI  - [Effects of passive immunization with anti-testosterone and anti-estradiol
      antibodies on the hypothalamo-hypophyseal-testicular axis in male rats].

PMID- 1030963
TI  - [Preliminary studies on the bacteriolytic activity of microbial enzymes].

PMID- 1030964
TI  - [Determination of plasma 25-hydroxycalciferol using the competitive protein
      binding method].

PMID- 1030965
TI  - [Cardiovascular and respiratory reflex changes during rhythmic or tetanic
      muscular exercise induced by electric stimulation of the muscles of the rabbit
      hindlimb].

PMID- 1030966
TI  - [Preliminary observations on the use of a perfusion system with pulsed flow for
      study of resistance in the musculo-cutaneous circulation].

PMID- 1030967
TI  - [Morphostructural characteristics of the buffalo thyroid].

PMID- 1030968
TI  - [Connections between the pancreas and choledochus in the rat].

PMID- 1030969
TI  - [Influence of 2-bromo-alpha-ergocryptine on the action of some psychotropic
      drugs. Research on rat mammae].

PMID- 1030970
TI  - [Effects of isometric exercise on the behavior of the systolic time intervals in
      normal untrained subjects. V].

PMID- 1030971
TI  - [Possible significance of a left bundle branch block associated with extreme left
      deviation of the axis].

PMID- 1030972
TI  - [Myocardial perforation during left ventriculography].

PMID- 1030973
TI  - [Comparison between human "capillary" pulmonary pressure and left atrial
      pressure].

PMID- 1030974
TI  - [Early mobilization in myocardial infarct].

PMID- 1030975
TI  - [Microcatheterization in the diagnosis of certain complications during the acute
      phase of myocardial infarct].

PMID- 1030976
TI  - [Radical surgical correction of Fallot's tetralogy with iatrogenic thrombosis of
      the left pulmonary artery].

PMID- 1030977
TI  - [Report on the first 100 cases of reconstructive arterial surgery].

PMID- 1030978
TI  - [Surgical aspects of embolism in mitral cardiopathy].

PMID- 1030979
TI  - [Arrhythmia during the postoperative course in patients after heart surgery].

PMID- 1030980
TI  - [Retrograde left atrial catheterization: indications and results].

PMID- 1030981
TI  - [Treatment of supraventricular tachycardia with ATP in adults and children].

PMID- 1030982
TI  - [Indications for emergency myocardial revascularization].

PMID- 1030983
TI  - [Surgical revascularization of the celiac-mesenteric region in impending
      intestinal infarct].

PMID- 1030984
TI  - [Importance of the handgrip test in the functional evaluation of the left
      ventricle during heart catheterization].

PMID- 1030985
TI  - [Effects of dynamic exercise on the behavior of the systolic time intervals in
      normal untrained subjects. I].

PMID- 1030986
TI  - [Effects of dynamic exercise on the behavior of the systolic time intervals in
      subjects with hypoxic myocardiopathy. II].

PMID- 1030987
TI  - [Therapy of paroxysmal supraventricular tachycardia].

PMID- 1030988
TI  - [Peripheral vascular functional studies in hypertensive, arteriosclerotic,
      dyslipidemic and normolipidemic subjects].

PMID- 1030989
TI  - [Behavior of various blood coagulation parameters and of platelet aggregation in
      normolipidemic patients with arteriosclerosis and hypertension].

PMID- 1030990
TI  - [Analysis of various blood coagulation indices in a group of hypertensive,
      arteriosclerotic and dyslipidemic patients with post-prandial
      hypertriglyceridemia].

PMID- 1030991
TI  - [Measurement of the aorta-renal cortex circulation time in normal and
      hypertensive subjects].

PMID- 1030992
TI  - [Plasma renin activity at rest and after stimulation in normal and hypertensive
      subjects].

PMID- 1030993
TI  - [Systemic arterial hypertension associated with portal hypertension due to
      congenital liver cirrhosis].

PMID- 1030994
TI  - [Evaluation of certain angiographic data in the diagnosis of renal hypertension].

PMID- 1030995
TI  - [The effect of propranolol in arterial hypertensive syndromes with high plasma
      renin activity].

PMID- 1030997
TI  - [Esophageal electrocardiography in intermittent right and left bundle branch
      block].

PMID- 1030996
TI  - [Treatment of sinus tachycardia].

PMID- 1030998
TI  - [Esophageal electrocardiogram in left anterior hemiblock].

PMID- 1030999
TI  - [Esophageal electrocardiography in complete right and left bundle-branch blocks].

PMID- 1031000
TI  - [Hemodynamic effects of carbochromene].

PMID- 1031001
TI  - [The frequency of the mesotelesystolic click in school age (a mass study in the
      elementary schools of the Community of Florence)].

PMID- 1031002
TI  - [The modifications in glycemia and insulinemia (I.R.I.) in heart decompensation].

PMID- 1031003
TI  - [External cardiomechanic indices in the evaluation of ischemic heart diseases.
      Correlations with the hemodynamic data].

PMID- 1031004
TI  - [Electro-vectorcardiographic problems in acute myocardial infarct associated with
      mono or plurifascicular block].

PMID- 1031005
TI  - [Practical value of polygraph studies in patients with valve prostheses (Long and
      medium term studies)].

PMID- 1031006
TI  - [Longitudinal study on the morbidity and mortality of patients with artificial
      pacemakers].

PMID- 1031007
TI  - [Polygraphic studies in the evaluation of coronary disease].

PMID- 1031008
TI  - [Vectorcardiographic data in patients with induced stimulation].

PMID- 1031009
TI  - [Correlation between plasma concentration and therapeutic activity of digoxin in
      the treatment of atrial fibrillation and indications for the association of beta
      blockers].

PMID- 1031010
TI  - [Clinico-pathological correlations in a case of primary cardiac
      rhabdomyosarcoma].

PMID- 1031011
TI  - [Immediate and further prognosis of intraventricular conduction disorders in
      acute myocardial infarct].

PMID- 1031012
TI  - [A case of parietal fibroplastic endocarditis with hematic eosinophilia].

PMID- 1031013
TI  - [Regional kinetics of the left ventricle with regard to the development of
      anastomotic circulation in coronary disease patients].

PMID- 1031014
TI  - [Effects of a particular hypocaloric diet for the obese patient with
      cardiovascular disease].

PMID- 1031015
TI  - [Catecholamine activity in aortic coarctation].

PMID- 1031016
TI  - [Correlations between plasmatic renin and aldosterone in essential arterial
      hypertension with sympathetic hyperactivity].

PMID- 1031017
TI  - [Changes in hemodynamics and in arterial PO2 during the acute phase of myocardial
      infarct].

PMID- 1031018
TI  - [Hemodynamic changes in the acute phase of myocardial infarct. Clinico
      therapeutic implications. Preliminary report].

PMID- 1031019
TI  - [Preexcitation syndrome and ventricular fibrillation].

PMID- 1031020
TI  - [Variant angina and coronary spasm].

PMID- 1031021
TI  - [Use of the chest-thump in supraventricular paroxysmal tachycardia].

PMID- 1031022
TI  - [Sports activities in subjects over 40 years old: value of electrocardiography at
      the end of athletic performance].

PMID- 1031023
TI  - [Short PQ--normal QRS syndrome].

PMID- 1031024
TI  - [The effect of bretylium tosylat on the human atrio-ventricular and
      intraventricular conduction].

PMID- 1031025
TI  - [The clinical use of dopamine in resuscitation].

PMID- 1031026
TI  - [Electro and vectrocardiographic findings of changes in the cardiovascular
      apparatus during pregnancy].

PMID- 1031027
TI  - [Left bundle branch block with normal septal activation].

PMID- 1031028
TI  - [Stimulation of left atrial tension receptors and regulation of pulmonary artry
      resistance in the swine].

PMID- 1031029
TI  - [Aspects of spontaneous rehabilitation in the infarct patient].

PMID- 1031030
TI  - [Beta blockers and myocardial metabolism in normal subjects and patients with
      angina pectoris].

PMID- 1031031
TI  - [Vectorcardiographic aspects of left posterior bundle branch block].

PMID- 1031032
TI  - [The atrial esophagocardiogram in polygraphic studies].

PMID- 1031033
TI  - [The behavior of the atrial esophagocardiogram in mitral valve diseases].

PMID- 1031034
TI  - [Angina pectoris with normal coronarography: description of a case with
      deficiency of cardiac isoenzymes of LDH].

PMID- 1031035
TI  - [Viral myocardium pericarditis. Study of 11 cases].

PMID- 1031036
TI  - [Physiopathological and clinical significance of the recovery time of the sinus
      node].

PMID- 1031037
TI  - [The use of an injectable anti-aldosteron agent in the treatment of secondary
      hyperaldosteronism].

PMID- 1031038
TI  - [Electrophysiological studies on a case of W.P.W].

PMID- 1031039
TI  - [Ventricular fibrillation in "sick sinus syndrome"].

PMID- 1031040
TI  - [The flow-volume curve in congestive cardiac insufficiency].

PMID- 1031041
TI  - [Behavior of the respiratory mechanics in cardiac insufficiency and in uremia due
      to acute dehydration].

PMID- 1031042
TI  - [Juvenile infarct. Case report].

PMID- 1031043
TI  - [Left anterior hemiblock and postero-inferior infarct. Vectorcardiographic
      study].

PMID- 1031044
TI  - [The behavior of the myocardial contractility indices during changes of the
      intraventricular volume. Experimental study].

PMID- 1031045
TI  - [The importance of demonstration of aortic insufficiency in the angiographic
      diagnosis of Valsalva's sinus aneurysm].

PMID- 1031046
TI  - [Apicocardiography: new contributions to its clinical value].

PMID- 1031047
TI  - [Prosthetic heart valve substitution during the first 15 years of life].

PMID- 1031048
TI  - [Measurement of the ventricular systolic time intervals by means of a mini
      calculator].

PMID- 1031049
TI  - [Doppler echocardiography with pulse wave].

PMID- 1031050
TI  - [Hemodynamic aspects of the acute phase of myocardial infarct: prospective
      therapy].

PMID- 1031051
TI  - [Behavior of various endocrine and metabolic parameters in heart patients treated
      with glucagon].

PMID- 1031052
TI  - [Electro-vectorcardiographic pictures of ischemia or necrosis with normal
      coronarography].

PMID- 1031053
TI  - [Incidence of bronchopneumopathies in patients with chronic ischemic heart
      disease].

PMID- 1031054
TI  - [Angina pectoris with normal coronarography: metabolic data in 3 clinical cases].

PMID- 1031055
TI  - [Effect of alphamethyldopa on kidney function and of plasma renin activity in
      arterial hypertensive syndromes].

PMID- 1031056
TI  - [Studies on the neuro-humoral regulation of blood circulation. Variations in the
      plasma renin activity due to changes in posture in normal young subjects].

PMID- 1031057
TI  - [Studies on the neuro-humoral regulation of blood circulation. Relationship
      between plasma renin activity and the arterial tonicity index in the lower
      extremities in normal young subjects].

PMID- 1031058
TI  - [Thrombelastographic findings in normal subjects and patients with coronary
      disease after exercise].

PMID- 1031059
TI  - [The cholinergic component in the genesis of musculocutaneous vasodilation
      induced by electric stimulation of the dog carotid sinus nerve].

PMID- 1031060
TI  - [Obstruction of the outflow from the right ventricle by an aneurysm of Valsalva's
      sinus].

PMID- 1031061
TI  - [Importance and limits of rapidly ingested beta blockers in the differential
      diagnosis of changes in the repolarization phase].

PMID- 1031062
TI  - [The radiocardiographic method in the semiquantitative evaluation of left to
      right shunts].

PMID- 1031063
TI  - [The ejection fraction of the right ventricle in mitral valve diseases before and
      after surgical correction].

PMID- 1031064
TI  - [Significance of the regurgitation index in the evaluation of mitral valve
      insufficiency].

PMID- 1031065
TI  - [Quantitative cineangiocardiography: computerized elaboration of the left
      ventricular images].

PMID- 1031066
TI  - [Evaluation of the filtration pressure of the platelet aggregates in a group of
      coronary patients].

PMID- 1031067
TI  - [Internal cardiac stimulation with an external permanent pacemaker].

PMID- 1031068
TI  - [Effects of digoxin on the human plasma renin activity].

PMID- 1031069
TI  - [The effect of propranolol on various types of hypertension in the rat].

PMID- 1031070
TI  - [The effect of propranolol on capillary permeability in normal and hypertensive
      rats].

PMID- 1031071
TI  - [Polygraphic studies in ischemic heart disease. Correlation with the findings of
      left cineventriculography].

PMID- 1031072
TI  - Acute conjunctivitis in a rural Egyptian community.

PMID- 1031073
TI  - Management of resistant cases of herpetic keratitis using cryo-immunotherapy
      technique.

PMID- 1031074
TI  - Free conjunctival graft as a temporary treatment for large corneal fistula.

PMID- 1031075
TI  - Bilateral simultaneous Mooren's ulcers with binasal and bitemporal pterygia. "A
      possible aetiological and pathological correlation".

PMID- 1031076
TI  - Surgical uses of scleral graft other than retinal detachment operations.

PMID- 1031077
TI  - Measurement of the depth of anterior chamber using Jaeger micrometer and
      gonioscopic studies of the angle in normotensive Egyptian eyes.

PMID- 1031078
TI  - Corneal curvature in normal and raised intraocular pressure.

PMID- 1031079
TI  - Histopathological study of Schlemm's canal and adjacent structures in glaucoma.

PMID- 1031080
TI  - Intra-ocular pressure after tonography.

PMID- 1031081
TI  - Management of glaucoma. New concepts.

PMID- 1031082
TI  - Diagnostic cytology in some conjunctival diseases.

PMID- 1031083
TI  - Modification of cyclodialysis operation.

PMID- 1031084
TI  - Trepano-trabeculectomy in the surgical treatment of glaucoma.

PMID- 1031085
TI  - Cyclodialothermy operation. (Preliminary report).

PMID- 1031086
TI  - Non reformation of anterior chamber due to disease of its linning endothelium.

PMID- 1031087
TI  - The subscleral Mortada operation. (Subscleral trap door sclerotomy with nasal
      pillar iris inclusion).

PMID- 1031088
TI  - Cataract extraction under general anaesthesia and mannitol osmotherapy.

PMID- 1031089
TI  - Prophylactic circlage before cataract extraction in high myopes. "Preliminary
      report".

PMID- 1031090
TI  - The absolute indication for cryo cataract extraction with Mortada multiple
      methods technique.

PMID- 1031091
TI  - Artifictal lens transplantation following cataract surgery. A promising method
      for treating cataracts.

PMID- 1031092
TI  - Results of simple needling for soft cataract.

PMID- 1031093
TI  - Retinal detachment. Past, present, and future.

PMID- 1031094
TI  - Non drainage of subretinal fluid with the encircling silastic 3mm, band in
      retinal detachment surgery.

PMID- 1031095
TI  - Aiming at prevention of complications of scleral buckling by silastic rod or band
      without evacuation of subretinal fluid.

PMID- 1031096
TI  - The encircling silastic 3 mm band without cautery in retinal detachment surgery.

PMID- 1031097
TI  - Posterior unbuckled part of a giant tear behind the oblique encircling silastic
      3mm band operation. Surgical prevention & treatment. (Incision of half scleral
      thickness opposite anterior and posterior margins of the oblique encircling
      silastic 3mm band in a wider area than the giant tear meridians extent. Modified
      Mortada operation.

PMID- 1031098
TI  - Sjogren's syndrome manifested by different ocular and systemic findings.

PMID- 1031099
TI  - More experience with encircling silastic 3mm band without evacuation of
      subretinal fluid in retinal detachment surgery. Mortada operation: one of the
      three international techniques.

PMID- 1031100
TI  - Biochemical composition and physical properties of the human vitreous body.

PMID- 1031101
TI  - Some biochemical and physical changes occurring in the vitreous body following
      choroido-retinal and vitreal injury in rabbit eyes.

PMID- 1031102
TI  - Fluorescein angiography.

PMID- 1031103
TI  - Interpretation of fluorescein angiography.

PMID- 1031104
TI  - Fluorescein angiography and photocoagulation in retinal branch vein occlusion.

PMID- 1031105
TI  - Reports on placoid pigment epitheliopathy.

PMID- 1031106
TI  - Optic atrophy following repeated courses of tartar emetic for the treatment of
      bilharziasis.

PMID- 1031107
TI  - Impending thrombosis of the central retinal vein.

PMID- 1031108
TI  - What is new about the treatment of diabetic retinopathy by calcium dobesilae
      (Doxium).

PMID- 1031109
TI  - Subarachnoid Terson's syndrome and vitreous haemorrhage.

PMID- 1031110
TI  - Various ocular findings in Groenblad- syndrome.

PMID- 1031111
TI  - Muscle transposition in sixth nerve palsy.

PMID- 1031112
TI  - Evaluation of partial myomectomy as a squint operation.

PMID- 1031113
TI  - Pathological study of extraocular muscles in diabetes mellitus.

PMID- 1031114
TI  - Studies on the incidence of refractive errors in Egypt.

PMID- 1031115
TI  - Lid gangrene with a case report.

PMID- 1031116
TI  - Correlation between serum, tissue cholesterol and chalazion formation.

PMID- 1031117
TI  - Surgical correction of congenital blepharo-ptosis with epicanthus, and blepharo
      phimosis.

PMID- 1031118
TI  - Ptosis of eyebrow.

PMID- 1031119
TI  - Phlebography in unilateral proptosis.

PMID- 1031120
TI  - A simplified external dacryocystorhinostomy. Steps and review of twelve cases.

PMID- 1031121
TI  - Trachoma of the lacrimal sac.

PMID- 1031122
TI  - Blindness in the Middle East.

PMID- 1031123
TI  - Ocular complications of corticosteroids.

PMID- 1031124
TI  - Combination of subconjunctival and I.V. riverin for prophylaxis after intra
      ocular surgery.

PMID- 1031125
TI  - The management of potassium permanganate ocular burn.

PMID- 1031126
TI  - Blood vitamin "A" level and dark adaptation.

PMID- 1031127
TI  - A hard or a soft contact lens.

PMID- 1031128
TI  - Experimental ocular toxoplasmosis.

PMID- 1031129
TI  - The dry eye and its management.

PMID- 1031130
TI  - Toxoplasma infection after instillation of the vegetative parasite in the
      conjunctival cul-de-sac of rabbits.

PMID- 1031131
TI  - Ocular toxoplasmosis among domestic rabbits in Egypt.

PMID- 1031132
TI  - The pathology of conjunctival blood vessels in diabetes mellitus.

PMID- 1031133
TI  - Study of pathological changes in the extra and intraocular blood vessels in
      diabetes mellitus.

PMID- 1031134
TI  - Management of intraocular hydatid cyst.

PMID- 1031135
TI  - Effect of propranolol and phenylbutazone on the prostaglandin like activity of
      the rabbit's iris in endotoxin induced iritis.

PMID- 1031136
TI  - Study of corneal thickness and curvature of Egyptian eyes.

PMID- 1031137
TI  - A cytological study of corneal scrapings from cases of herpes simplex keratitis.

PMID- 1031138
TI  - Epidemic haemorrhagic conjunctivitis.

PMID- 1031139
TI  - [Progress report of work in process].

PMID- 1031140
TI  - [An experimental contribution on the study of active immune protection].

PMID- 1031142
TI  - [Pharmacological importance of the introduction and acclimatization of medical
      plants in the Socialist Republic of Serbia].

PMID- 1031141
TI  - [Progress report on current work].

PMID- 1031143
TI  - [Margins of virology].

PMID- 1031144
TI  - [Nonocclusive myocardial infarct].

PMID- 1031145
TI  - [Various problems related to the etiopathogenesis of diabetes mellitus].

PMID- 1031146
TI  - [Problems in endemic nephropathy].

PMID- 1031147
TI  - Plasma tyrosine levels in normal subjects and in abnormalities of thyroid
      function.

PMID- 1031148
TI  - "Elimination of ascorbic acid in urine of normal man".

PMID- 1031149
TI  - "Multiple penile cutaneous horns".

PMID- 1031150
TI  - All India Ophthalmological Society (in retrospect).

PMID- 1031151
TI  - List of medical colleges in India.

PMID- 1031152
TI  - Rhinosporidiosis and the eyes.

PMID- 1031153
TI  - Electrophoretic pattern of serum proteins in Eale's disease.

PMID- 1031154
TI  - Dictyoma.

PMID- 1031155
TI  - Lymphomatous pseudo-tumour of the choroid with secondary retinal detachment.

PMID- 1031156
TI  - Intra-orbital dermoid with malignant metaplasia.

PMID- 1031157
TI  - Hydatid cyst of orbit.

PMID- 1031158
TI  - Bilateral primary anophthalmos.

PMID- 1031159
TI  - Pleomorphic adenoma of Krause's gland.

PMID- 1031160
TI  - Intermarginal strip lymphangioma (a case report).

PMID- 1031161
TI  - Flexible contact lenses and our experience with 'Sauflon 70' lenses in aphakia.

PMID- 1031162
TI  - Presidential address.

PMID- 1031163
TI  - Health services in India.

PMID- 1031164
TI  - Panel discussion--leprosy.

PMID- 1031165
TI  - Obituary.

PMID- 1031166
TI  - Bacterial meningitis in the pediatric age.

PMID- 1031167
TI  - Renal cell carcinoma (hypernephroma): the great masquerader.

PMID- 1031168
TI  - Maternal and child health and family planning.

PMID- 1031169
TI  - The case against mandatory continuing medical education.

PMID- 1031170
TI  - Medical mission in Guatemala.

PMID- 1031171
TI  - Veiscocutaneous conduit a method of permanent urinary diversion: fifteen year
      follow-up.

PMID- 1031172
TI  - Improved technique for lumbar epidural anesthesia.

PMID- 1031173
TI  - Anomalies of branchial cleft origin.

PMID- 1031174
TI  - Hypertension control: where do we stand in Alabama?

PMID- 1031175
TI  - Platelets and drugs.

PMID- 1031176
TI  - Primary, secondary, and tertiary medical care.

PMID- 1031177
TI  - Etidocaine (duranest): a new long acting local anesthetic for epidural
      anesthesia.

PMID- 1031178
TI  - Emergency medicine.

PMID- 1031179
TI  - [Abnormal immunoglobulins and their clinical significance (author's transl)].

PMID- 1031180
TI  - [Function of neutrophils in newborns (author's transl)].

PMID- 1031181
TI  - [Studies on a new measurement method of platelet size and its clinical
      significance (author's transl)].

PMID- 1031182
TI  - [Studies on the phagocytosis of the red cells from the patients with autoimmune
      hemolytic anemias by human monocytes (author's transl)].

PMID- 1031183
TI  - [Studies on the changes of the pattern of serum proteins in various cases of
      leukemia--correlation between serum proteins and the clinical pictures in
      leukemia (author's transl)].

PMID- 1031184
TI  - [Report of a young patient with multiple myeloma complicating myelomatous
      pleurisy and pyroglobulinemia (author's transl)].

PMID- 1031185
TI  - [Isolation of a cultivable mycobacterium from an armadillo subcutaneous tissue
      infected with M. leprae and characterization of this isolated strain (author's
      transl)].

PMID- 1031186
TI  - [Clinical studies on so-called phobic cases to Hansen's disease (author's
      transl)].

PMID- 1031187
TI  - [Autoimmunity].

PMID- 1031188
TI  - [Progresse in the health care for mother and child in undeveloped areas].

PMID- 1031189
TI  - [Malignant tumors due to vinyl-chloride exposure].

PMID- 1031190
TI  - [Immunization of the tourist for international travel].

PMID- 1031191
TI  - [Detection of hypertension during mass screening in Titograd].

PMID- 1031192
TI  - [Organized action against drug dependence].

PMID- 1031193
TI  - [Epidemiology of measles and obligatory immunization].

PMID- 1031194
TI  - [Cerclage in the prevention of spontaneous abortion and premature labor.
      Experiences at the "Boris Kidric" in health institute 1966-1975].

PMID- 1031195
TI  - [Relationship between the anticonvulsive effect of phenobarbital and serum
      levels].

PMID- 1031196
TI  - [Treatment with high doses of fluphenazine hydrochloride].

PMID- 1031197
TI  - [Charcot-Marie-Tooth disease].

PMID- 1031198
TI  - [Exhibitionism].

PMID- 1031199
TI  - [Electroclinical confrontation of temporal changes in the child].

PMID- 1031200
TI  - [Analysis of epileptic seizures in acute cerebrovascular attacks].

PMID- 1031201
TI  - [Psychoses with abnormal EEG].

PMID- 1031202
TI  - [Problems of education and social status of epileptic children at the elementary
      schools of the former community "Crnomerec"].

PMID- 1031203
TI  - [Methodology of the socialization of psychiatric patients under extramural
      conditions].

PMID- 1031204
TI  - [Effect of hemispherectomy on mental condition and epileptic seizures in patients
      with infantile hemiplegia].

PMID- 1031205
TI  - [Views of patients on etiology, development and prognosis of mental disorders
      (survey of the results of an epidemiological study based on autoanamnestic
      data)].

PMID- 1031206
TI  - [Long-term studies and results or rehabilitation in patients with prolonged
      cerebral coma].

PMID- 1031207
TI  - [Hereditary persistent distal cramps in 2 additional families].

PMID- 1031208
TI  - [Nasal glioma-encephalocele or tumor].

PMID- 1031209
TI  - [Unusual intracranial localization of an ectopic tooth].

PMID- 1031210
TI  - [Clinical and therapeutic experiences in a case of cerebellar medulloblastoma].

PMID- 1031211
TI  - [Long-term effect of lignocaine on myotonic dystrophy and on the "stiff man"
      syndrome].

PMID- 1031212
TI  - Effect of prolonged trifluoperazine, imipramine and haloperidol administration on
      serum cholesterol. An experimental study in rabbits.
AB  - As a result of prolonged intragastric administration of trifluoperazine (TFZ) and
      imipramine in rabbits, a significant rise in serum cholesterol was observed after
      4, 8 and 12 weeks. Haloperidol was ineffective. Hypercholesterolemia produced by
      TFZ was not associated with increased estriol excretion in urine. Histochemical
      examination of aorta of TFZ-treated animals showed positive 'Schultz's reaction'
      for cholesterol, suggesting a possible causal relationship between TFZ-induced
      hypercholesterolemia and atherogenesis.

PMID- 1031213
TI  - Protection of carrageenin edema and trypsin hydrolysis of bovine serum albumin by
      naphthylthiosemicarbazides and their cyclized oxadiazoles.
AB  - Seven 1-(naphth-1-ylacetyl)-4-substituted thiosemicarbazides were synthesized and
      cyclized to the corresponding 2-(naphth-1-ylmethyl)-5-arylamino-1,3,4
      oxadiazoles. All compounds, with the exception of two slbstituted oxadiazoles,
      possessed low anti-inflammatory activity. The protection afforded by these
      compounds against carrageen-in-induced edema ranged from 3 to 43% where
      cyclization, in general, decreased anti-inflammatory activity. All compounds (1
      mM), possessed antiproteolytic activity where in vitro protection of trypsin
      induced hydrolysis of bovine serum albumin, in most cases was greater with
      oxadiazoles.

PMID- 1031214
TI  - The effect of diftalone on collagen and glycosaminoglycans metabolism.
AB  - Diftalone showed a distinct inhibition effect on the collagen formation in sponge
      granuloma as well as in chick embryos articular cartilage. The inhibitory effect
      was expressed even in corneal and articular cartilage glycosaminoglycans (GAG)
      sulphation and GAG formation in granulation tissue. According to our previous
      results diftalone showed a similar inhibition of collagen and GAG biosynthesis as
      other effective antirheumatic drugs.

PMID- 1031215
TI  - The lymphocytic absorption of p,p'-DDT and some structurally-related compounds in
      the rat.
AB  - The lymphatic absorption of a series of 14C-labelled compounds structurally
      related to p,p'-DDT has been examined in thoracic duct-cannulated rats. The
      compounds (p,p'-DDT, p,p-DDT, P,P'-DDD, p,p-DDD, DDE, DDA and 2,4-D) varied
      markedly in lipid solubility, as well as in extent of lymphatic absorption,
      urinary and biliary excretion, and localization in body fat. More than 12% of the
      dose was recovered in 24-hour thoracic duct lymph of rats treated with the p,p'-
      and o,p-isomers of DDT and DDD and with DDE, and this percentage was increased by
      concomitant fat absorption. A strict parallel between lipid solubility and
      lymphatic absorption was not observed in this series of compounds, possibly
      because of differences in their rates and routes of excretion.

PMID- 1031216
TI  - Displacement of albumin-bound antimicrobial agents by bilirubin.
AB  - The ability of bilirubin to displace antimicrobial agents from their binding
      sites on albumin was studied in vitro by equilibrium dialysis. Sulfonamides,
      tetracyclines, penicillins and cephalosporins of different degrees of protein
      binding were tested. It was found that bilirubin reduced the protein binding of
      all four classes of antimicrobial agents, although by varying degrees. This
      effect was most pronounced with the compounds which had the highest degree of
      protein binding, such as cloxacillin, cephazolin, methacycline and sulfisoxazole,
      all of which are bound greater than 80% by albumin. On the other hand, the drugs
      with less than 25% binding, such as ampicillin, cephalexine and tetracycline were
      not ostensibly displaced by bilirubin. Scatchard plots of the binding of
      sulfamethoxazole to albumin in the presence of 400 mumol/1 of bilirubin, showed
      that bilirubin almost completely displaced the sulfonamide molecule from the high
      affinity site on the albumin molecule. Reduced protein binding of drugs in
      hyperbilirubinemic infants may have pharmacokinetic significance.

PMID- 1031217
TI  - Inhibitory action of aliphatic alcohols on smooth muscle contraction.
AB  - The addition of 0.05-0.20 mM CaCl2 to the isolated guinea pig ileum immersed in a
      depolarizing (excess potassium), and calcium-free Tyrode solution produces a dose
      related contraction, which is reversibly blocked by aliphatic alcohols of low
      molecular weight. The inhibitory potency of the alcohols increases with the
      length of their carbon chain, and may be due to an interference with the movement
      of calcium across the smooth muscle cell membrane.

PMID- 1031218
TI  - [Angiodysplasia of the colon].
AB  - The authors present a case review of a congenital abnormality of the inferior
      mesenteric blood vessels which resulted in ischemia of the descending colon and
      rectosigmoid area. The resulting colitis is only very rarely secondary to a
      vascular congenital abnormality. In this case, rectosigmoidoscopy, barioum study
      of the large bowel and a biopsy of the rectal mucosa pointed towards the ischemic
      nature of the lesion. This led to the selective angiographic study of the
      inferior mesenteric vessels with findings of a dilated inferior mesenteric artery
      and angiodysplasia. Surgical treatment included tying off of the inferior
      mesenteric artery and resection of the descending and rectosigmoid colon followed
      by transverse colon-rectum anastomosis. The angiographic and histopathologic
      studies were of great importance in establishing the true nature of the patient's
      clinical syndrome. One must keep in mind that the rectosigmoidoscopic findings
      may be seen in other disease states which do not have a vascular origin. These
      include Crohn's disease, severe amoebiasis and penumatosis of the intestine.

PMID- 1031219
TI  - [Retrograde jejuno-gastric invagination as a complication of gastric surgery].
AB  - A review of the world's medical literature concerning retrograde jejunal-gastric
      invagination reveals that it is a very unusual complication. It is sometimes seen
      following gastric surgery and presents with the clinical picture of a high
      intestinal occlusion. From the clinical point of view the diagnosis is difficult
      but the radiologic study with contrast medium is always useful. Nonetheless,
      thirty percent of the cases are diagnosed correctly only at autopsy. There are
      now 146 cases published in the literature and in all the etiologic factors are
      different from those observed in other types of invagination. Early diagnosis and
      treatment improve the prognosis and eliminate a fatal outcome, as is seen in the
      two cases herein presented.

PMID- 1031220
TI  - [Congenital stenosis of the large and small intestines].

PMID- 1031221
TI  - [Cholecystocholedochal ascaridiasis].
AB  - Ascaridiasis, as shown by Stoll is one of the most frequent parasitosis the world
      over; in our country is very frequent and its incidence is greater in the
      tropical areas. The emigration of the ascari to the biliary tract is cause of
      obstructive jaundice and acute cholecystitis. The clinical picture sometimes is
      taken for the one produced by biliary lythiasis. In the two cases presented the
      diagnosis was made during the trans-operative period. Ascaridiasis of the biliary
      ducts is more frequent in women; as judged by our cases and the cases reported by
      Lopez Dominguez, Laviada and Tovia. The surgical treatment in our cases was
      cholecystectomy and cholocostomy with good results. This entity should be kept in
      mind as cause of obstructive jaundice or acute cholecystitis.

PMID- 1031222
TI  - [Spontaneous perforation of the bile ducts in childhood].
AB  - At the pediatric surgery service of Centro Medico La Raza during 20 years six
      spontaneous perforations of biliary ducts have occurred. Two groups of causes are
      proposed; the first includes previous biliary ducts malformations with two sub
      groups, one with great malformations as partial atresia, cystic dilatation and
      cystic disease of the biliary tract; the second sub-group includes weak areas.
      The second group has no previous pathology. Precipitating causes are infections
      and obstructions. Three of the six patients corresponded to duct perforation and
      three to gallbladder perforation; the initial diagnosis was different to biliary
      pathology in all the patients. Male were predominant; there was no previous
      pathology in any patient; this is difficult to interpret as all of them presented
      with important morphologic changes. Treatment possibilities are discussed
      comparing our experience with others'.

PMID- 1031223
TI  - [Aproximation to the concept of social medicine].

PMID- 1031224
TI  - [Health examinations].

PMID- 1031225
TI  - [2 normal methods for the determination of sulphur dioxide in the atmosphera and
      an statistical study of their analytical technic. Part II. Method of the para
      rosanilin method].

PMID- 1031226
TI  - [Relation between the pathogenicity of the Staphylococcus and its chromogenes,
      fermentative and gelatinolytic properties].

PMID- 1031227
TI  - [Epidemiological consideration and control of infectious enteric processes in the
      Badajoz region].

PMID- 1031228
TI  - [Study of the habit of smoking in a group of cancer patients].

PMID- 1031229
TI  - [Basic principles and trends in laboratory research on zooanthroponoses in
      epidemiological practice].

PMID- 1031230
TI  - [Ultrastructure of the human gastric corpus epithelium during ontogenesis].

PMID- 1031231
TI  - [Mitochondria morphometry of rat heart muscle cells after chronic intermittent
      disorders of oxygen consumption of various origins].

PMID- 1031232
TI  - Spermatogenesis in free living mite, Pergamasus viator Halas. (Parasitidae,
      Mesostigmata). II. Spermiogenesis.
AB  - The paper presents the results of ultrastructural studies on the spermiogenesis
      in the mite, Pergamasus viator Halaskova. The cysts containing 16 spermatids per
      cyst, are localized in the anterior part of the saccular gonad. The process of
      spermatid maturation has been divided into three stages: of the early spermatid,
      middle spermatid and late spermatid. The modifications of spermatid occuring
      during the spermiogenesis include: a change of cell shape, modifications of its
      organelles and formation of new structures like the superficial layer of cellular
      processes, striated bodies, granular bodies, flattened cisternae and canaliculi,
      central canaliculi, and stiff bands. Within the nucleus the chromatin condenses
      to threads or lamellae, to form subsequently several electron-dense granules. The
      remaining nucleoplasm is filled with an electron-dense material, which appears in
      the middle spermatid and gradually accumulates. The above modifications occuring
      in the course of spermiogenesis and their relation to the data available from the
      literature concerning the spermatogenesis of allied groups of animals are
      discussed in length.

PMID- 1031233
TI  - Neuroendocrine organs of the lemon-butterfly, Papilio demoleus L. II. The corpora
      cardiaca-allata complex of the adult.
AB  - The retrocerebral endocrine organs of the adult lemon-butterfly; Papilio demoleus
      have been described. The organs are subaortic lying closely behind the brain.
      While the nervi corporis cardiaci I (NCCI) originate from the protocerebrum of
      the brain, the NCCII seem to take their origin in the tritocerebrum in common
      with another nerve named earlier as the tegumentary nerve. The corpora cardiaca
      (CC) and corpora allata (CA) are closely approximated to each other obliterating
      the nervi corporis allati (NCA) which are conspicuous in the larva of the same
      species. An intercardiacal bridge (ICB) connects the CC of the two sides and acts
      as a possible centre of distribution for the neurosecretory material (NSM) to the
      gut. Histological evidence suggests that the NSM inside the CC remains
      intraaxonal without being primarily unloaded in the organs for storage. The
      intrinsic secretory cell of the CC are intimately associated with the
      neurosecretory fibres from the brain and bear fairly thick axons. No NSM could be
      detected in the CA of this insect.

PMID- 1031234
TI  - Comparative histochemical observations on the steroid-synthesizing cellular sites
      in the testes of nonmammalian vertebrates.

PMID- 1031235
TI  - The effect of carbofuran-toxication on the chloragogen tissue of Tubifex tubifex
      Mull. (Oligochaeta).
AB  - Chloragogen cells, subserving ion exchange and electron accepting functions, were
      studied in Tubifex tubifex after insecticide treatment. Chloragogen cells were
      strongly influenced by in vivo carbofuran poisoning. The first alterations in the
      chloragogen cells became activated, both the formation and release of the
      chloragosomes reached a high rate. The released chloragosomes were phagocytosed
      by the amoebocytes. At an advanced stage of the toxication a heavy loading of the
      apical cytoplasm of chloragogen cells with lipid droplets, finally degenerative
      changes both in the chloragogen cells and amoebocytes were observed. Possible
      mechanisms of the carbofuran toxication and of the protective function of
      chloragogen cells in T. tubifex are discussed.

PMID- 1031236
TI  - Histology and seasonal changes in the testes of a hill-stream fish Schizothorax
      plagiostomus.
AB  - Histology and annual cyclic changes in the testicular activity of S. plagiostomus
      have been described. The reproductive cycle has been divided into eight phases.
      The weight and volume of the testes and GSI show correlation with each other, and
      increase twice in a year (September and March), indicating the existence of two
      spawning periods. A distinct dormant period during winter intervenes the spawning
      peaks. Although the testes contain mature spermatozoa during winter, spermiation
      remains halted until last week of February. On the return of favourable
      environmental conditions in March, spermiation begins again and complete
      depletion takes place.

PMID- 1031237
TI  - An electron microscope cytochemical study of calcium ion localization in the
      honey-bee flight muscle.
AB  - The authors studied the sarcomere ultrastructure and distribution of calcium ions
      in the cross striated flight muscles (longitudinal-dorsal and tergosternal) of
      the honey bee after being fixed in osmium tetraoxide and buffered to 7.4 pH and
      also according to the method of Carasso and Favard (1966). they ascertained an
      intensive and constant reaction to the presence of calcium on the level of
      myofilaments within the periphery of the sarcomeres and light and dark
      mitochondria. Calcium concentrations are not detectable in the Z line and M line.
      The authors carried out a control of the results using the method of Carasso and
      Favard (1966).

PMID- 1031238
TI  - Efferent connections of the nucleus lateralis posterior-pulvinar complex in the
      cat.
AB  - The nucleus lateralis posterior-pulvinar complex of the thalamus displays an
      integrative function. The efferent connections of this nuclear group were
      examined by the authors in the cat. In their work, they utilized also the earlier
      observations on the afferent connections of the nucleus. The nuclear complex
      projects to the associative fields encompassed by the visual- and the acoustic
      cortex without intruding into the primary cortical areas. On the other hand, its
      afferent connections are, apart from the associative field, also yielded by the
      primary visual and acoustic cortex. All this is completed by the reciprocal
      connections of the LP-pulvinar complex with the visual- and acoustic system, as
      well as between the associative areas of the cortex.

PMID- 1031239
TI  - The relationship between heat production and body temperature in the new-born and
      the adult guinea pig after termination of exposure to hypoxia and hypercapnia:
      with notes on body weight vs. body surface as the frame of reference.

PMID- 1031240
TI  - The central effect of 5-hydroxytryptamine, gamma-amino-butyric acid and carbachol
      on thermoregulation in the neonatal guinea pig.
AB  - 5-Hydroxytryptamine (10 microgram), gamma-amino-butyric acid (20 microgram) and
      carbachol (1 microgram) were injected through the soft skull into the lateral
      cerebral ventricle of guinea pigs aged 2 to 12 days, at the slightly subneutral
      ambient temperature of 30 degrees C. 5-Hydroxytryptamine (5-HT) produced no
      immediate change in oxygen consumption, whereas colonic temperature fell rapidly.
      One hour after injecting 5-HT, when colonic temperature had decreased by about
      0.5 degrees C, oxygen consumption increased and after a lag of 30--40 min was
      followed by an increase in colonic temperature. Gamma-amino-butyric acid (GABA)
      increased oxygen consumption and colonic temperature after a latency of 30--60
      min. Carbachol was followed by an immediate decrease in colonic temperature and
      oxygen consumption. Colonic temperature was below the pre-injection level
      throughout the five-hour period of observation.

PMID- 1031241
TI  - The central effect of noradrenaline on thermoregulation in the neonatal guinea
      pig.
AB  - Noradrenaline (10 microgram) injected into the lateral cerebral ventricle of
      guinea pigs aged 2 to 12 days produced a rapid increase in oxygen consumption and
      in colonic temperature at an ambient temperature of 30 degrees C. The increase
      was most pronounced in the youngest animals and decreased with advancing age, but
      was still significant at 12 days of age. Species differences and the role of
      ambient temperature in the responses are discussed.

PMID- 1031242
TI  - Effects of prostaglandin E1 (PGE1) on the positive inotropic response of heart
      muscle to elevation of external Ca++-concentration, to increased driving
      frequency, and to paired stimulation.
AB  - Electrically driven left guinea pig atria were exposed to positive inotropic
      stimuli which are thought to be related to the turnover of calcium ions. For
      increasing contractibility, the following procedures were used: a) varying the
      concentration of CaCl2 in the bath fluid; b) stimulation at frequencies from 1.0
      to 3.0 Hz; c) paired stimulation. Positive inotropic responses to the increase of
      the rate of stimulation and to paired stimulation were not affected by 0.1
      microgram/ml tetrodotoxin (TTX). This excludes the adrenergic contribution to the
      positive inotropic effects observed. Actions of the positive inotropic stimuli
      were studied both in the absence and in the presence of 0.1--1.0--10.0--1000.0
      ng/ml of PGE1-PGE1 in the highest concentration used increased contractile force.
      The inotropic stimulus-response curves were not affected by PGE1 at any
      concentration. This finding suggests there is no interaction between Ca ions and
      PGE1 in the contractile mechanism of the guinea pig heart muscle.

PMID- 1031243
TI  - Factors influencing the urinary fluoride level in subjects drinking fluoride-poor
      waters.
AB  - The influence on the urinary F level of the short-term consumption of drinking
      water of 1 mg/litre fluoride content, of the ingestion of low (1.0 to 2.0 mg) and
      higher (7.0 and 8.0 mg) fluoride doses and of tea has been studied. Excess
      fluoride is rapidly excreted with urine, and may disturb the results of urinary
      fluoride estimation. The urinary F level responds sensitively to the ingestion of
      fluorine.

PMID- 1031244
TI  - Effect of drinking waters of high fluorine content on the urinary fluoride level.
AB  - The urinary fluoride level has been studied in 307 subjects consuming drinking
      waters of different fluoride concentrations. The urinary fluoride level was found
      to increase with the fluoride content of the drinking water. The urinary F level
      of the population group drinking water of optimum fluoride concentration was 1.14
      mg of fluoride per litre. Thus, in regions where the drinking water contains an
      insufficient amount of fluoride, the fluoride content of domestic salt must be
      adjusted so as to ensure an about 1.14 mg/litre urinary F level of the
      population.

PMID- 1031245
TI  - Urinary fluoride levels of population groups consuming salts different in
      fluoride concentration.
AB  - The effect of urinary level of a prolonged consumption of table salts containing
      200, 250 or 350 mg/kg of fluoride has been studied. Urinary F concentration was
      increasing with all the three kinds of salt. In the group of consumers using 200
      and 250 mg F/kg salt the equilibrium has been reached, but the urinary F level
      was still below that observed in populations who are drinking water of 1 mg/l F
      concentration. The equilibrium in the 2--14-year age groups consuming 350 mg F/kg
      salt could not yet set in. It is concluded that even a mixture of 350 mg F/kg is
      not in excess of the optimum and is far from the tolerated limit. Thus, this
      latter mixture may be used for caries prevention in areas with F-deficient
      drinking water, although it may be still less than the optimum.

PMID- 1031246
TI  - Concentration dependence of the veratrine effect on inducing depolarization and
      membrane potential oscillation in skeletal muscle.
AB  - The concentration dependence of the effect of veratrine in inducing
      depolarization and membrane potential oscillation in the frog sartorius muscle
      has been studied. (1) On increasing the veratrine concentration from 0.025 to 1
      mM, the latency period of the development of membrane potential oscillation and
      depolarization is proportionally shortened. (2) On changing the veratrine
      concentration from 0.025 to 1 mM, the magnitude of depolarization is raised
      logarithmically. (3) When the veratrine concentration reaches 0.05-0.1 mM, both
      the amplitude and the frequency of the membrane potential oscillation increase.
      On rising to 1 mM, a further increase in frequency to eight-fold occurs
      especially in the later phase of oscillation. At this concentration range, the
      amplitude of oscillation inversely proportional to the concentration of
      veratrine. (4) On increasing the veratrine concentration above 0.1 mM, the
      membrane potential oscillation ceases after a temporary rise of frequency. This
      inhibitory effect of veratrine is, however, reversible, and oscillations appear
      again, despite the absence of veratrine in Ringer's solution. This also proves
      the persistance of the veratrine effect.

PMID- 1031247
TI  - Effect of intraventricular oxytocin and vasopressin on self-stimulation in rats.
AB  - Oxytocin (500 mu u) and vasopressin (50 mu u) were injected into the lateral
      ventricle and its effect on hypothalamic self-stimulation has been studied.
      Oxytocin increased, while vasopressin decreased the self-stimulation rate tested
      10-20 min following application. The hypothalamic and mesencephalic serotonin
      content decreased slightly while plasma corticosterone content did not change 20
      min after oxytocin and vasopressin administration compared to the injected
      control animals. The data suggest that vasopressin and oxytocin have an opposite
      effect on self-stimulation and this action is not mediated through the brain
      serotoninergic or pituitary-adrenocortical axis.

PMID- 1031248
TI  - [Effect of age on the de-iodation of 1-diiodotyrosine and 1-thyroxine in the rat
      liver and kidney in vitro].

PMID- 1031249
TI  - Studies on Erysipelothrix rhusiopathiae carriership in large pig herds.

PMID- 1031250
TI  - The effect of urethane (ethylcarbamate) on the reproduction of Trypanosoma
      equiperdum.

PMID- 1031251
TI  - On the pharmacokinetics of sulphonamide + trimethoprim combination orally
      administered to geese.

PMID- 1031253
TI  - Influence of enthalpy and air humidity on heat equilibrium and heat production in
      fattening pigs.

PMID- 1031252
TI  - Data on the developmental cycle of Philometra obturans (Pregnant, 1886)
      (Nematoda: Phlometridae).

PMID- 1031254
TI  - Attempts for immunization of partridges (Perdix perdix) against Newcastle
      disease.

PMID- 1031255
TI  - Studies on the correlation between the results of the haemagglutination
      inhibition test and the immunity against Newcastle disease.

PMID- 1031256
TI  - Effect of dietary nitrogen level on electrolyte and water metabolism in sheep. K+
      metabolism II.

PMID- 1031257
TI  - [Gravity and behavior (psychophysiologic approach)].

PMID- 1031258
TI  - [Atmospheric ionization and its effects on the behavior of animals and man].

PMID- 1031259
TI  - [Memorization of drawings or nouns according to the material used in
      recognition].

PMID- 1031260
TI  - [Spatial localization and oculo-motor activity; a genetic study].

PMID- 1031261
TI  - [Surgical aspects of myasthenic thymopathies].

PMID- 1031262
TI  - [Intrathoracic neurogenic tumors].

PMID- 1031263
TI  - [Cystic hamartomas of the mediastinum (consideration of 20 observed cases)].

PMID- 1031264
TI  - [Hemangioma of the mediastinum (review of the literature and report of a personal
      case)].

PMID- 1031265
TI  - [Mediastinal lymphangioma (with a report on 3 personal cases)].

PMID- 1031266
TI  - [The function of the sinus node in conduction disorders].

PMID- 1031267
TI  - [Preliminary studies on the TCI/TC relation in cardiodynamics].

PMID- 1031268
TI  - [Calcium antagonists in Prinzmetals angina].

PMID- 1031269
TI  - [Echocardiographic analysis of the movements of the interventricular septum in
      left bundle branch block].

PMID- 1031270
TI  - [Echocardiographic study of the mitral valve movements during acute myocardial
      infarct].

PMID- 1031271
TI  - [Latest studies on propranolol induced variations in excretion of
      catecholamines].

PMID- 1031272
TI  - [Arterial pressure and age in a limited Apulian community].

PMID- 1031273
TI  - [Possible effect of the water-salt metabolism on the action of dopamine on the
      kidney].

PMID- 1031274
TI  - [The Romano Ward syndrome. Description of a case].

PMID- 1031275
TI  - [Common truncus arteriosus of monoventricular origin with atresia of the aortic
      arch. 1 case].

PMID- 1031276
TI  - [Analysis of the exercise induced changes of the atrial vectorcardiogram in
      mitral valve stenosis by means of electronic elaborator].

PMID- 1031277
TI  - [Plasma renin activity in patients with essential hypertension. 1. Results].

PMID- 1031278
TI  - [Considerations on the arrhythmic cholecysto-cardiac syndrome].

PMID- 1031279
TI  - [Contribution to acute myocardial infarct in young women].

PMID- 1031280
TI  - [Usefulness and limitations of echocardiographic diagnosis in the evaluation of
      mitral valve disorders].

PMID- 1031281
TI  - [Clinical considerations on a group of patients with arterial hypertension
      treated with propranolol].

PMID- 1031282
TI  - [Effect of isometric exercises on the behavior of the systolic time intervals in
      subjects with hypoxic heart disease. VI].

PMID- 1031283
TI  - [Effects of isometric exercise on the behavior of the systolic time intervals in
      patients with arterial hypertension. VII].

PMID- 1031284
TI  - Perche ascoltare il cuore all'articolazione cleido-sternale destra?

PMID- 1031285
TI  - [Effects of epidrazine on renal hemodynamics in hypertensive patients].

PMID- 1031286
TI  - Effect of the acute administration of PGA1 on arterial pressure and on kidney
      function essential arterial hypertension.

PMID- 1031287
TI  - [Echocardiographic study of the interventricular septum in 249 heart patients].

PMID- 1031288
TI  - [Isometric exercise test in the evaluation of left ventricular function by means
      of echocardiography].

PMID- 1031289
TI  - [Pulsed wave doppler echocardiography in the diagnosis of aortic diseases].

PMID- 1031290
TI  - [Polygraphic and echocardiographic study of 47 patients with mitral valve
      prosthesis].

PMID- 1031291
TI  - [The normalized medium speed of the circumferential muscle fiber stretch (MVCL)
      used as an index for relaxation in the construction of left ventricular function
      curves].

PMID- 1031292
TI  - [Echocardiographic evaluation of left ventricular function in myocardial
      diseases: effects of strophanthin].

PMID- 1031293
TI  - [Echocardigraphic and polygraphic correlations between the sounds and the
      systolic and diastolic intervals in normal subjects].

PMID- 1031294
TI  - [Echocardiographic study of myxedematous heart disease].

PMID- 1031295
TI  - ["Myocardial bridges": a possible cause of ischemia?].

PMID- 1031296
TI  - [Acute myocardial infarct in chronic cor pulmonale, clinical, hemodynamic and
      blood gas analytical aspects].

PMID- 1031297
TI  - [An unstable coronary syndrome with favorable outcome].

PMID- 1031298
TI  - [Isolated his-bundle block during acute myocardial infarct].

PMID- 1031299
TI  - [Treatment of hereditary angioedema with a plasmatic concentrate of CU esterase
      inhibitor].

PMID- 1031300
TI  - [Comparison of various indices of "stiffness" and "compliance" of the right
      ventricle in diverse hemodynamic situations].

PMID- 1031301
TI  - [Evaluation of the optimal pulmonary artery telediastolic pressure level in acute
      myocardial infarct].

PMID- 1031302
TI  - [The difference of the place of injection of the contrast medium for the
      calculation of the ejection fraction].

PMID- 1031303
TI  - [Hemodynamic changes after left ventriculography].

PMID- 1031304
TI  - [Mitral valve prolapse and ventricular pre-exitation syndrome].

PMID- 1031305
TI  - [Effect of contraction on the distribution of coronary flow].

PMID- 1031306
TI  - [The pneumatic collar in the study of the human carotid baroreceptor reflex].

PMID- 1031307
TI  - [The distribution of the coronary flow with a perfusion pressure superior to the
      left ventricular systolic pressure].

PMID- 1031308
TI  - [Interaction between norepinephrine, calcium and the frequency of stimulation on
      the behavior of the potassium flow in the Purkinje fibers].

PMID- 1031309
TI  - [Adreno-sympathetic activity in chronic cor pulmonale and in chronic respiratory
      insufficiency].

PMID- 1031310
TI  - [Value of the "ejection interval" in the control of patients with pacemakers].

PMID- 1031311
TI  - [Effect of magnesium cations on myocardial contraction. Comparative analysis of
      the effects of 2 different ways of administration the systolic time intervals].

PMID- 1031312
TI  - [The effect of the cardiac oxydation-reduction potential and the myocardial
      lactate consumption on coronary resistances].

PMID- 1031313
TI  - [Hemodynamic findings by means of cardiac microcatheterization in essential
      hypertension during rest and after exertion].

PMID- 1031314
TI  - [Special electrophysiological aspects of sinus node reentry].

PMID- 1031315
TI  - [Functional organization of the hypothalamic center inhibiting the sympathetic
      nervous system. I. Sympathetic and vagal mechanisms of the bradycardial effect
      and relationship with sino-aortic reflexes].

PMID- 1031316
TI  - [Functional organization of the hypothalamic center inhibiting the sympathetic
      nervous system. II. Characteristics of vasodilation in the iliac, mesenteric and
      renal region].

PMID- 1031317
TI  - [Plasma levels of various formulations of oral digoxin, and correlated indices of
      myocardial function in the healthy subject and in the decompensated patient].

PMID- 1031318
TI  - [Coronary disease during primary hyperuricemia].

PMID- 1031319
TI  - [Electrocardiographic changes in progressive systemic sclerosis and their
      relationship with various clinical aspects of the disease].

PMID- 1031320
TI  - [Study on renal responsiveness to physiological stimuli in hypertensive
      patients].

PMID- 1031321
TI  - [Evaluation and significance of the plasma renin activity in hypertension].

PMID- 1031322
TI  - [Validity of 131Cs scintigraphy and echocardiography in the early diagnosis of
      postinfarctional aneurysm].

PMID- 1031323
TI  - [Radiofrequency pacemaker in refractory arrhythmia with protracted evolution. Its
      use in a child with paroxysmal tachycardia].

PMID- 1031324
TI  - [Protective effect of salt depletion on angina due to atrial pacing].

PMID- 1031325
TI  - [Prindolol induced electrophysiological modifications].

PMID- 1031326
TI  - [Electrophysiological modifications induced by selective coronarography in
      subjects with normal coronary vessels].

PMID- 1031327
TI  - [Contribution to the vectorcardiographic diagnosis of dorsal infarct].

PMID- 1031328
TI  - [Factorial study of the corrected sinus node recovery times].

PMID- 1031329
TI  - [The role of cardiac dyssynergia in the etiology of left ventricular dysfunction
      in myocardial infarct. Unbloody study of the systolic times and the
      cinecardiography of previous myocardial infarct].

PMID- 1031330
TI  - [Reentry circuits in paroxysmal supraventricular tachyarrhythmia during sick
      sinus syndrome].

PMID- 1031331
TI  - [Cardiodynamic effects of prostaglandin E1 in normal subjects].

PMID- 1031332
TI  - [Psychosomatic dynamics of essential hypertension evaluated by means of a
      quantitative psychosomatic method].

PMID- 1031333
TI  - [Place and value of the maleate of ethyl cinepazate (vascoril) among the anti
      angina agents].

PMID- 1031334
TI  - [Myocardial metabolism in mitral valve prolapse syndrome].

PMID- 1031335
TI  - [Effect of anti-hypertensive therapy on the response to force in patients with
      essential arterial hypertension].

PMID- 1031336
TI  - Low vision aids in the management of visual handicap.

PMID- 1031337
TI  - Benign adenomatous neoplasm (adenoma) of the middle ear.
AB  - This presentation is a study of the pathogenesis, clinical behaviour and
      therapeutic response of 20 cases of a primary adenomatous neoplasm confined to
      the middle ear cleft. The investigation supported origin of the tumour from the
      middle ear mucosal epithelium. Clinical behaviour was that of a benign,
      localized, non-metastasizing neoplasm. Simple localized surgical removal of the
      tumour afforded an excellent prognosis in all cases. The designation of the
      tumour entity as adenoma of middle ear is proposed.

PMID- 1031338
TI  - Aspirin idiosyncrasy in patients admitted for nasal polypectomy.
AB  - Investigation of 100 consecutive patients admitted for nasal polypectomy revealed
      only 3 patients with aspirin idiosyncrasy and asthma. It is important that this
      combination be recognized but fortunately this can be done by the history.
      Incidental findings were that nasal polypi are much commoner in men and that the
      incidence of atopy was the same as that in the general population.

PMID- 1031339
TI  - Anaesthesia for electrocochleography.
AB  - Until recently Ketamine has been the anaesthetic most commonly used for
      electrocochleography. It was believed that the use of a conventional anaesthetic
      machine would produce artifacts in the recordings but experience has shown that
      this is not the case; in fact quieter tracings are obtained due to the abolition
      of muscle potentials. Ketamine is preferred for children under 3 years old but
      the others receive a general inhalation anaesthetic. The intramuscular route is
      chosen for the administration of Ketamine in order to minimize the occurrence of
      hallucinations in the recovery period. Consistent results have been obtained with
      a dosage related to the metabolic rate of the child. One milligram of Ketamine is
      administered for each 35 cm2 of surface area. General inhalation anaesthesia is
      given by a semiopen circuit and an oral endotracheal tube is used. Induction is
      with methohexitone or nitrous oxide and halothane, and maintenance is also with
      nitrous oxide and halothane. The main drawback is pollution of the atmosphere of
      the sound-proofed testing room with halothane. This has been overcome by ducting
      the expired gases outside the room using an Enderby valve.

PMID- 1031340
TI  - Nasal polypi.

PMID- 1031341
TI  - Radiological bone changes produced by intraoral squamous carcinomata involving
      the lower alveolus.
AB  - Forty-eight per cent of patients with clinical involvement of the lower alveolus
      by an intraoral squamous carcinoma showed radiological evidence of bone
      involvement. This was usually an irregular invasive bone defect, but a smooth
      pressure erosion is also common. 'Floating teeth', displaced bony fragments,
      pathological fractures, and rarely an expanded inferior canal are less common
      radiological signs.

PMID- 1031342
TI  - Myringoplasty.
AB  - Myringoplasty is a deceptively difficult procedure in which surgical finesse and
      experience dictate success in terms of hearing improvement as well as closure
      rate. In essence, it is the complete removal of epidermal ingrowth followed by
      the placement of a non-epithelialized graft on the medial surface of the tympanic
      membrane which has withstood the test of time.

PMID- 1031343
TI  - What's wrong with British ENT?

PMID- 1031344
TI  - Functional laryngectomy (cricohyoidopexy).
AB  - Two techniques of subtotal functional laryngectomy are described: cricohyoidopexy
      which is used for supraglottic tumours, and cricohyoidoepiglottopexy for glottic
      tumours. These operations have been carried out on 61 patients, with tumours too
      extensive to be managed by the usual partial laryngectomy. The functional results
      are good, and 94% of the patients have been decannulated.

PMID- 1031345
TI  - Standard forms for results of audiometry: British Society of Audiology.

PMID- 1031346
TI  - Chronic laryngitis.

PMID- 1031347
TI  - Radiology in the diagnosis of acoustic neuroma.

PMID- 1031348
TI  - Observations on the stria vascularis of the guinea pig cochlea and the changes
      resulting from the administration of the diuretic furosemide.
AB  - An electron microscope examination of the stria vascularis of guinea pigs and the
      structural changes occurring after administration of furosemide has been made.
      The use of ruthenium-red, which stains cell coats, has shown that the atria is
      impermeable to the passive diffusion of material from both the endolymph and the
      spiral ligament. The first changes after administration of furosemide are
      observed 4 hours after injection; small spaces develop between the cells. After 5
      -6 hours the spaces have enlarged but the tight junctions between marginal cells
      remain intact. The intermediate cells show signs of atrophy. In severely affected
      animals the intermediate cells have so shrunk that the spaces are very large and
      the marginal cells clearly resolved. These latter cells show no structural
      damage. In this severely affected tissue it is seen that the blood vessels are
      entirely surrounded by marginal cell extensions. It is suggested that the
      intermediate cells may have a regulatory function. The damage appears to be
      recoverable, since 6 hours after injection the spaces have decreased in size
      although some signs of intermediate cell atrophy are still apparent.

PMID- 1031349
TI  - Multiple sclerosis. The value of clinical vestibular examination.
AB  - A clinical vestibular examination was carried out on 82 patients with multiple
      sclerosis (MS) selected on McAlpine's criteria. Spontaneous nystagmus, positional
      nystagmus or pathological caloric test were found in 49 (60%) patients.
      Pathological horizontal optokinetic nystagmus occurred in 47 (57%) patients. In
      36 cases horizontal optokinetic nystagmus was pathological to both sides, in 28
      cases combined with a pathological vertical optokinetic nystagmus, indicative of
      diffuse intracerebral lesions. Lesions in the central vestibular system and in
      the optokinetic pathways were frequently discovered in early or atypical cases of
      MS.

PMID- 1031350
TI  - A facial fatigability test: a method for detecting 'latent' facial motor lesions
      by fatigability.
AB  - This is a simple test for the early recognition of a clinically 'latent' facial
      motor lesion, which detects the difference in fatigability between the two sides
      of the peri-oral musculature. Fatigue is produced by the patient's effort to
      maintain maximal contraction against lateral traction of the angles of the mouth
      by two weighted hooks. Fatigue is expressed as the distance between the midline
      of the philtrum and a mark on each hook. Distance plotted against time gives a
      'facial fatigue curve'. In the authors ' experience the test has revealed
      pathological fatigability in 8 cases, 2 intrameatal and 4 large acoustic neuromas
      -1 of the four not yet confirmed by surgery--and 2 inflammatory processes in the
      internal auditory meatus, but failed in 1 of intrameatal acoustic neuroma.

PMID- 1031351
TI  - Pulmonary complications following supraglottic laryngectomy.
AB  - Supraglottic laryngectomy has been generally assumed to protect the patient from
      aspiration changes in the lungs. This paper details a retrospective survey, the
      results of which suggest that respiratory infections are common after
      supraglottic laryngectomy and that pneumonia is a fairly common cause of death.
      The need for prolonged follow-up after this operation is emphasized.

PMID- 1031352
TI  - Age-dependent distribution of isoamylases in human parotid saliva.
AB  - The number of isoamylases present in parotid saliva from 53 healthy men and women
      of different ages was determined. A basic pattern of 6 isoamylases was evident in
      all samples. With increasing age, an increasing number of additional isoenzymes
      was observed which migrated faster towards the anode. These 'fast isoamylases'
      are derived from the basic isoenzymes by deamidation. The significance of
      deamidation of proteins as age increases as well as the increasing number of
      'fast isoamylases' in saliva from mucoviscidosis patients are discussed.

PMID- 1031353
TI  - A quantitative study of microscopical changes in the epithelium and subepithelial
      tissue of the laryngeal folds, sinus and saccule.
AB  - The folds, sinuses and saccules from III unselected larynxs removed at autopsy
      were examined microscopically for epithelial and subepithelial abnormalities.
      Squamous metaplasia and 'dysplasia' of the vestibular and vocal folds
      respectively, particularly the former, were commoner in men than women. Two
      distinct varieties of 'dysplasia' were observed, and the close relationship
      between 1 of them and changes, possibly of vascular origin, in the subepithelial
      tissues of the vocal fold suggested cause and effect.

PMID- 1031354
TI  - The aetiology of chronic laryngitis.
AB  - Fifty-eight patients with chronic laryngitis, defined as diffuse laryngeal
      inflammation, of an average duration of approximately 1 year, were investigated.
      The sex incidence was equal and the average age 45 years. Occupational factors
      were of minor importance, and the smoking habits of the patients were the same as
      those of a similar matched population. Of the haematological factors
      investigated, anaemia, diabetes, renal disease and syphilis were of no importance
      whatsoever. The most important aetiological factor was sepsis of the upper and
      lower respiratory tracts which was present in over half the patients.

PMID- 1031355
TI  - Carcinoma in situ of the larynx--an unsatisfactory diagnosis.

PMID- 1031356
TI  - Radical neck dissection.
AB  - Radical neck dissection was described in 1906, and the following half century saw
      it being increasingly accepted without any significant change. More recently a
      number of differing concepts have arisen. While the value of the original radical
      operation is established, the more recent modifications are not yet substantiated
      by proper trials.

PMID- 1031357
TI  - Research.

PMID- 1031358
TI  - Multiple papillomatosis of the larynx in children.

PMID- 1031359
TI  - 'Fast isoamylases' in parotid saliva of heterozygous carriers of cystic fibrosis.
AB  - An increased number of 'fast isoamylases' is found in the parotid saliva of
      children with cystic fibrosis and their heterozygous parents who are clinically
      healthy. 'Fast isoamylases' are generated, at least in part, from the 6
      isoamylases of the basic pattern by deamidation of asparagine and glutamine
      residues. This basic pattern is present in the parotid saliva of all subjects we
      have tested so far. A shift in the equilibrium between amidation and deamidation
      processes is discussed in terms of its possible significance for the pathogenesis
      of cystic fibrosis and for ageing.

PMID- 1031360
TI  - Upper respiratory problems in the yellow nail syndrome.
AB  - A case of the Yellow Nail Syndrome is described. The characteristic nail changes
      were associated with pleural effusions, lymphoedema of the face and legs and
      upper respiratory symptoms. The finding of extremely hard ear wax has not been
      reported previously. A satisfactory response to combination diuretic therapy was
      seen. The case of recognition of the Syndrome is emphasized together with the
      danger of excessive investigation if the nails are not inspected. Possible
      mechanisms for the formation of extremely hard cerumen are discussed.

PMID- 1031361
TI  - [Ependyma of the cerebral ventricles in the white rat].

PMID- 1031362
TI  - Dynamic cardiac scintigraphy with a multi-imaging device.
AB  - Cardiac kinetics can be visualized in two ways after i.v. injection of
      radiopharmaceutics for labeling either the myocardium or the cardiac chambers.
      The simpler way is the acquisition of the data in analog mode, using a
      multiimaging device. Thanks to a short time constant for the image advance, the
      cardiac cycle is divided into 16 frames, the first being triggered by the R wave
      of the ECG. The data of a large number of synchronized cycles are integrated on a
      film. This permits an almost continuous way to follow the kinetics of the studied
      compartments along the cycle. Several views can be registered successively. This
      procedure yields separately immediate information on the morphology and dynamics
      of the myocardium, and chambers. To evaluate quantitatively various parameters of
      left ventricular function a data processor is connected to the gamma camera.
      Examples of the two types of data are shown and demonstrate that both are useful
      for appreciating the value of kinetics though they are not yet accurate enough to
      replace in every case contrast radiologic techniques. Nevertheless, the
      indications for these procedures are continuously growing, due to technical
      progresses and the noninvasive nature of the investigation.

PMID- 1031363
TI  - Myocardial scintigraphy.
AB  - Results of myocardial scintigraphy in 103 individuals are reported. This test
      method was introduced by the authors in 1973; 131Cs chloride served the purpose
      of tracer. Beside a group of 17 control individuals, 63 patients with myocardial
      infarction, 9 with myocardiosclerosis, and 14 with other affections were tested.
      The normal scintigram in full-face, profile, and left half-profile positions of
      the patient is first described, then the typical picture of these same positions
      in infarctions with anterior and posterior localizations, and also in
      myocardiosclerosis of various origin. The valuableness of the new radioisotope
      test method has been duly stressed. It affords direct and precise information
      about the localization and the extensiveness of the morbid process which has led
      to cicatricial alterations in the heart muscle.

PMID- 1031364
TI  - Pertechnetate uptake of joints in rheumatoid arthritis.
AB  - A new isotopic method for evaluation of inflammatory activity in rheumatoid
      arthritis is reported. By use of repeated whole body profile scanning a double
      tracer examination with 99mTc-pertechnetate and 113mIn-transferrin was performed.
      Total pertechnetate activity and total indium activity were measured over both
      hands, both feet, the ankles, and over the knee joints. In addition, the
      extravascular component of pertechnetate uptake and the ratio extravascular/total
      pertechnetate activity were calculated for these regions. The activity curves
      were followed up to 2 h after tracer injection in seven female patients
      presenting with rheumatoid arthritis and in six female controls. The four
      parameters calculated were compared and statistical analysis revealed the most
      significant discrimination of both groups for the ratio extravascular/total
      pertechnetate activity 2 h after injection (P less than 0.002).

PMID- 1031365
TI  - The use of technetium-99m labelled heat-damaged red cells for the quantitative
      measurement of splenic function.
AB  - A comparison of the rates of clearance of 51Cr labelled and 99mTc labelled heat
      damaged red cells in 25 patients and 4 control subjects is reported. Very little
      correlation was found between the clearance half-times of the two types of
      labelled cells when the cells were labelled with 99mTc prior to heat damaging.
      The correlation was improved when the labelling step occurred after the cells had
      been damaged. Urinary excretion measurements revealed that the rate of excretion
      of 99mTc could be as much as nine times that of the 51Cr label. 99mTc labelled
      heat-damaged red cells were found not to be sufficiently stable a preparation for
      use in quantitative clearance studies.

PMID- 1031366
TI  - A simple method of evaluating the penetrability of Spitz-Holter drains with the
      aid of radioisotopes.
AB  - A simple, reliable, and innocuous method is described for evaluating the
      penetrability of cerebrospinal shunts with the use of 99mTc O4. After introducing
      25 muCi of 99mTc O4 in a volume of about 0.2 ml into Rickham's reservoir, series
      scintigrams in the lateral or AP direction are made with the aid of a Nuclear
      Chicago Pho Gamma HP Scintillation Camera. The results are in satisfactory
      agreement with the surgical findings. No complications have so far been observed.

PMID- 1031367
TI  - Comparative evaluation of 99mTc-generators.
AB  - A total of 34 99mTc-generators from eight different manufactures were studied in
      1974 and 1975 with regard to their performance and to the quality of the eluates.
      With some exceptions the generators performed well and proved their ability to
      act as a reliable source of 99mTc-pertechnetate. Two cases of mechanical
      malfunction and two cases with a low elution yield of 99mTc were observed. Four
      generators were overloaded with 99Mo. The 99mTc-pertechnetate did in most cases
      fulfil the requirements of the Nordic Pharmacopeia.

PMID- 1031368
TI  - Studies of chemical and biological properties of 99mTc-DMS (dimercaptosuccinic
      acid)--renal imaging agent.
AB  - Studies of the chemistry of preparation of tin chelate 2.3-dimercaptosuccinic
      acid (DMS) complexed with 99mTc with respect to its biological properties have
      been made. We have varied molar ratio of reactants (DMS:Sn/II/), concentration of
      Sn-DMS chelate and pH of 99mTc-DMS injection solution and examined their
      influence on biodistribution. Biodynamics of labeled solution at time intervals
      of from 0.5 to 4 h have also been measured. Animal experiments were carried out
      on mice and rats. Radiochemical purity was checked by paper chromatography, thin
      layer chromatography, and gel-filtration through Bio-Gel P-2. A sterile, pyrogen
      free lyophilized "kit" for labeling, stable for 6 months, was made on the basis
      of achieved results. The results of its clinical application are also reported.

PMID- 1031369
TI  - 99mTc-Sn-acetylcysteine: a new renal scanning agent.
AB  - A new radiopharmaceutical, 99mTc-Sn-acetylcysteine, for renal scanning is
      reported. The preparation is simple and quick. It can also be adopted in the kit
      form. The complex has the advantage of great stability and fast clearance over
      earlier reported renal scanning radioagnostic agents.

PMID- 1031370
TI  - Radio diagnosis using 125I-fibrinogen and 203Hg-thymidine.
AB  - A comparative study of 125I-fibrinogen and 203Hg-thymidine using 144 Ehrlich
      carcinoma-bearing mice, indicates that tumor affinity of carrier substances with
      covalent labeling could be better used for scintigraphic tumor diagnosis.
      Halogenated or possibly metallo-organic compounds offer an alternative to the
      metal complexes in general use up to now.

PMID- 1031371
TI  - Nicotine-11C: synthesis and distribution kinetics in animals.
AB  - In order to study "in vivo" the distribution kinetics of (-)-nicotine in animals,
      this molecule was labeled with carbon-11. Two synthesis methods are described.
      Immediately after intravenous administration of (-)-nicotine-methyl-11C in
      rabbits the gamma-camera shows a strong radioactivity build-up in the brain and
      kidneys. The biological interest of this carbon-11 labeled molecule is discussed.

PMID- 1031372
TI  - Enhancement of abnormality in gamma images using Kohonen filters.
AB  - A new method of processing digital images consists of a numerical filter which
      suppresses normal features producing an enhancement of the abnormality. The
      resulting filtered image aids the observer in the recognition of the abnormality.
      The filter is developed from verified normal images in the computer memory. The
      enhancement of pathologic accumulations with respect to surrounding activity was
      improved on the average by a factor of 2.6 for 13 lateral brain images.

PMID- 1031374
TI  - An unusual case of typhoid fever.

PMID- 1031373
TI  - The effect of agar media on the in vitro susceptibility of Candida species to
      polyene antibiotics.

PMID- 1031375
TI  - Hereditary spherocytic anemia--report of 54 cases.

PMID- 1031376
TI  - Cystic tuberculosis of patella.

PMID- 1031377
TI  - Aetiology of Indian childhood cirrhosis: a new hypothesis.

PMID- 1031378
TI  - Diabetes and rheumatoid factor.

PMID- 1031379
TI  - A survey of fungi from eye patients in Lucknow.

PMID- 1031380
TI  - Retinal abnormalities in albino rats.

PMID- 1031381
TI  - Lymphoid pseudotumours or pseudolymphomas of the orbit.

PMID- 1031382
TI  - Angiomatous implantation cyst of the conjunctiva.

PMID- 1031383
TI  - Enterobius vermicularis in the human conjunctival sac.

PMID- 1031384
TI  - Orbital lymphangioma (regression with corticosteroids).

PMID- 1031385
TI  - Complicated microphthalmos.

PMID- 1031386
TI  - Role of optometrist in ophthalmic practice.

PMID- 1031387
TI  - Free amino acids in cataractous lenses.

PMID- 1031388
TI  - Pinguecula and pterygium (a histopathological study).

PMID- 1031389
TI  - Marginal keratitis produced by phthirus pubes.

PMID- 1031390
TI  - An accessory optic disc.

PMID- 1031391
TI  - Pseudoxanthoma elasticum--a case report.

PMID- 1031392
TI  - Dacryocystography and surgery in pseudo sac.

PMID- 1031393
TI  - Raised intraocular tension following the use of alpha-chymotrypsin in cataract
      surgery.

PMID- 1031394
TI  - Unilateral proptosis due to fibrous dysplasia.

PMID- 1031395
TI  - Ketamine and intraocular pressure.

PMID- 1031396
TI  - Mycotic flora of trachomatous conjunctiva.

PMID- 1031397
TI  - Peripheral nerve tumours of the orbit.

PMID- 1031398
TI  - Anisometropic amblyopia.

PMID- 1031399
TI  - Ocular injuries due to caterpillar hairs.

PMID- 1031400
TI  - Orbital fibrous dysplasia.

PMID- 1031401
TI  - Hydatid cyst of the orbit.

PMID- 1031402
TI  - Bilateral medial rectus palsy due to nuclear involvement in closed head injury (a
      case report).

PMID- 1031403
TI  - Alveolar rhabdomyosarcoma.

PMID- 1031404
TI  - Dacryocystography and lacrimal probing in cases of congenital obstruction of
      nasolacrimal duct.

PMID- 1031405
TI  - Slit lamp photography of the eye.

PMID- 1031406
TI  - Retained foreign body in orbito-maxillary region.

PMID- 1031407
TI  - Ophthalmic manifestations of the toxicity of ethambutol.

PMID- 1031408
TI  - Fractures in haemophilia.
AB  - Eight cases of fractures in haemophiliac patients are presented. The clinical and
      radiological features, behaviour and response to treatment indicate that they are
      normal, not pathological fractures. If fractures in haemophiliac patients are
      treated early and correctly both from a haematological and orthopaedic point of
      view, the results are comparable with those in normal subjects. The
      haematological and orthopaedic management is discussed.

PMID- 1031409
TI  - External skeletal fixation with continuous adjustment of stability and
      compression.
AB  - A method of external fixation with continuous adjustment of stability is
      described. It allows interfragmentary compression, even on oblique surfaces in
      any plane and even when applied only on one side of the bone.

PMID- 1031410
TI  - Bilateral posterior iliac osteotomy as a preliminary stage in the surgical
      treatment of exstrophia vescicae.
AB  - Bilateral posterior iliac osteotomy as a preliminary stage in the surgical
      treatment of congenital extrophy of the bladder allows easier approximation of
      the soft tissues in front of the urethra and facilitates closure of the rectal
      muscles and fasciae, reducing or abolishing the need for using fascial strips and
      carrying out plastic procedures to close the skin.

PMID- 1031411
TI  - Metacarpal loss treated by metatarsal substitution.
AB  - In the hand severe trauma and tumours are the most frequent causes of loss of
      bone substance in the metacarpals. To save the function of the complete digital
      ray repair by bone grafting is essential. A technique is described for
      transferring all or part of a metatarsal bone as a hemiarticular graft for
      substituting metacarpal bone loss.

PMID- 1031412
TI  - Aneurysmal bone cyst (a study of 127 cases, 72 with longterm follow up).
AB  - 127 cases of aneurysmal bone cyst are analysed, seventy two of which were
      followed up from one to fifteen years after treatment. Statistics on sex, age,
      site and localisation are reported. Symptoms, radiographic features, histological
      appearances and differential diagnosis are discussed. In half the cases the cyst
      was clearly shown to be of subperiosteal origin. The aetiology is unknown, but
      the pathogenesis seems to consist of a haemorrhagic and hyperplastic (not
      neoplastic) process which is progressive but has a tendency to become stabilised
      on reaching a certain point of maturation. Local excision is indicated or, in
      cases where this is difficult to carry out, radiotherapy. Recurrences occurred in
      12 per cent of the cases, always within one year after operation. All cases were
      eventually cured and there was no evidence of malignant transformation.

PMID- 1031413
TI  - Exposure in the post-operative management of surgical wounds. Report of a trial.
AB  - The ancient method of leaving operative wounds completely exposed to the air
      throughout the healing period is assessed on the basis of a trial in 100 surgical
      wounds (excluding traumatic wounds and wounds of the hand and knee). The method
      offers two chief advantages; the wound can be regularly and easily inspected, and
      any collection of secretions which can lead to skin complications and superficial
      sepsis can be dealt with. The results are analysed and compared favourably with
      those of conventional dressing techniques.

PMID- 1031414
TI  - Sympathetic disorders in obstetrical paralysis of the newborn.
AB  - In addition to the classical description of involvement of the cervical
      sympathetic in low root lesions (Claude Bernard-Horner syndrome), other
      sympathetic syndromes have been described accompanying the motor and sensory
      changes in obstetrical paralysis of the upper limb. Loss of sweat secretion can
      be deomonstrated by electrical skin resistance tests, and the authors describe
      their apparatus and method of investigating this in the newborn. Although sweat
      secretion is often scanty in the newborn, it can be enhanced with appropriate
      techniques, particularly in the areas richer in sweat glands. This method of
      investigating sympathetic nerve function has been used to clarify the location of
      the neurological damage and therefore it is of some value for the prognosis in
      obstetrical paralysis of the newborn.

PMID- 1031415
TI  - Experimental model for studying the invasive characteristics of malignant tumours
      transplanted in bone and muscle of rats.
AB  - The subject of experimental research in bone oncology is comparatively neglected
      in the literature though it is recognised that such research could offer
      fundamental contributions to our knowledge of the biological behaviour of tumours
      in bone. A model for experimental study is proposed which is easy to carry out
      and effective in producing results. It consists of transplanting a highly
      malignant tumour with a 100 per cent "take" rate, such as Guerin's T8 or
      Oberling's aleukemic myeloma, in the tibia or femur of the rat. Some
      morphological and histochemical changes associated with the invasion and spread
      of these tumours in bone are reported. Observations were also made on their
      behaviour in muscle.

PMID- 1031416
TI  - New aspects of the structure of articular cartilage. The "tidemark" seen on the
      scanning electron microscope.
AB  - New observations are reported based on scanning electron microscopy, of the
      interface ("tidemark zone") between articular cartilage and the underlying
      calcified strata; also on the structure of adult articular cartilage.

PMID- 1031417
TI  - Ewing's sarcoma of the soft tissues? Case report.
AB  - A case is reported of a malignant tumour of the soft tissues of the leg, with
      histological and pathological features comparable with those of Ewing's sarcoma
      of bone. This extension of the term Ewing's sarcoma to the soft tissues is
      proposed and the differential diagnosis is discussed.

PMID- 1031418
TI  - Haemangioma of bone with radiographic appearances simulating a giant cell tumour.
AB  - A case is described of haemangioma of the proximal end of the humerus which
      simulated a giant cell tumour on radiography. An attempt at biopsy, carried out
      elsewhere, had failed because of severe haemorrhage from the tumour during
      operation. It was treated by en bloc resection and endoprosthesis with a good
      result after one year.

PMID- 1031419
TI  - Intradural lumbar disc hernia. Report of two cases.
AB  - Penetration of disc tissue inside the dural sac in the lumbar region ("intradural
      disc hernia") is a rare occurrence. Two cases are described which presented as
      multi-root syndromes of the cauda equina. Some clinical aspects are discussed
      together with the pathogenesis, diagnosis and treatment of this rare type of disc
      hernia.

PMID- 1031420
TI  - Human dignity in living and dying.

PMID- 1031421
TI  - Surgically treatable asthma.

PMID- 1031422
TI  - Oral contraceptives: which one for my patient?

PMID- 1031423
TI  - A study of diagnoses made in a rural community hospital emergency room.

PMID- 1031424
TI  - Estimating the need for physicians in Alabama.

PMID- 1031425
TI  - Mercy caring vs. mercy killing.

PMID- 1031426
TI  - Diabetic retinopathy: an overview.

PMID- 1031428
TI  - Physician requirements for Alabama relationship to the new HSA's.

PMID- 1031427
TI  - Antenatal diagnosis of genetic defects.

PMID- 1031429
TI  - Current applications of diagnostic ultrasound in the abdomen.

PMID- 1031430
TI  - Barbiturate endarteritis of foot.

PMID- 1031432
TI  - The individual doctor. He need not walk alone.

PMID- 1031431
TI  - Efforts underway to improve rural health care in Alabama.

PMID- 1031433
TI  - Child abuse: scourge of society.

PMID- 1031434
TI  - False positive liver scans.

PMID- 1031435
TI  - Anticoagulation in acute myocardial infarction.

PMID- 1031436
TI  - "Dedicated to serving a privileged class".

PMID- 1031437
TI  - Pediatrics in colonial America.

PMID- 1031438
TI  - Neurilemmoma of the cervical portion of the vagus nerve: differentiation from a
      carotid artery aneurysm.

PMID- 1031439
TI  - How many doctors?

PMID- 1031440
TI  - "I woke and found that life was duty"--anon.

PMID- 1031441
TI  - The training of scientific experts.

PMID- 1031442
TI  - Physical methods for the comparison of illicitly produced tablets.

PMID- 1031443
TI  - Shot-gun injury of the chest: an exit hole.

PMID- 1031444
TI  - Interaction between methadone and ether peroxides to produce 1,5-dimethyl-3, 3
      diphenyl-2-ethylidene-pyrrolidine the major cyclic metabolite of methadone.

PMID- 1031445
TI  - Changes in blood cyanide as a function of storage time and temperature.

PMID- 1031446
TI  - Copper levels in human tissue.

PMID- 1031447
TI  - Differentiation of the genetic variants of glucose-6-phosphate dehydrogenase in
      bloodstains by electrophoresis on cellulose acetate.

PMID- 1031448
TI  - Isotachophoresis of bloodstains.

PMID- 1031449
TI  - Response to glucagon of low-birth-weight infants with early intravenous glucose
      infusion.

PMID- 1031450
TI  - Irreversible inhibitory effect of atropine on the contractile responses to drugs
      in isolated rat rectum, particularly in relation to Ca.

PMID- 1031451
TI  - Irreversible inhibition by atropine of drug-induced contractions in isolated
      rabbit ileum, particularly in relation to the mobilization of Ca.

PMID- 1031452
TI  - Studies on drug nonequivalence. V. Gastrointestinal absorption of polymorphs of
      sulfameter.

PMID- 1031453
TI  - Influence of the removal of external K on tonus and drug-induced contractions of
      the isolated rat ileum, particularly in relation to Ca.

PMID- 1031454
TI  - [On lingular disease the diagnosis of which has been established for the first
      time after 33 year-history of Hanseniasis (author's transl)].

PMID- 1031455
TI  - [Studies of clinical course and prognosis of Hansen's disease during
      chemotherapy. 2. Erythema nodosum leprosum in lepromatous leprosy (author's
      transl)].

PMID- 1031456
TI  - [Autopsy report and investigation into the cause of death among lepers in
      colonies in 1974].

PMID- 1031457
TI  - Mental health implications of economic growth in developing countries.

PMID- 1031458
TI  - The duo-drama.
AB  - A model of psychotherapy based on a 'dramatic look' is presented. It is an aspect
      developed from the demotorization of psycho-drama reduced to two actors Dialogue 
      in the sense of Plato and Buber - is looked at as action and dealt with
      accordingly. A pre-step of interpretation: confrontaion is used 'in flagranti'
      within the framework of here and now. The patient is continuously confronted with
      his 'action'.

PMID- 1031459
TI  - Policy decisions and the reduction of mental hospitalization of the aged.
AB  - Inappropriate hospitalization of elderly persons in mental institutions has been
      a cause for much concern. Reduction of this type of hospitalization has become an
      accepted national policy. The observed variations among the states in the rates
      and trends of hospitalization of aged patients may indicate that trends income
      states are more congruent with national policy than those in others. In an effort
      to account for the wide variation among the states, time trend analyses of rate
      changes of hospitalized aged were made for a sample of states. These reveal that
      there are relationships between impatient trends and specific policies and
      programs for the aged. The results provide insights into mental hospitalization
      of elderly persons, and indicate how the inappropriate mental hospitalization of
      the aged can be reduced.

PMID- 1031460
TI  - On the rights of the mentally ill: a Hellenic view.

PMID- 1031461
TI  - The role of the community mental health centre in prevention.
AB  - The writer discusses some theoretical concepts regarding community psychiatry and
      the role of the community mental health centre with special attention to the
      primary preventative programmes, the limitations of the field of influence and
      the scope of activity within any given community. It would appear that most
      psychiatrists see their work as the delivery of psychiatric care, hopefully
      resulting in secondary and tertiary prevention. While the healing and supportive
      functions are of major significance, the mental health community centre has also
      an important educative part to play in primary prevention, in helping to upgrade
      the well-being and the social competence of the people in its sphere of
      influcence.

PMID- 1031462
TI  - Is it possible to educate a psychiatrist?
AB  - The author, who served as Executive Secretary and Editorial Consultant to the
      Conference on Education of Psychiatrists held in June 1975, presents here in some
      of the major findings, concerns, and dilemmas encountered by the conferees as
      they considered the current status of psychiatric education and the course it
      should take in the coming decade. The fundamental problem is that there is no
      firm consensus defining what a modern psychiatrist is or what he sould be.
      Basically the complete psychiatrist sits on a three-legged stool of biological,
      psychological, and social science. But the stool wobbles because the legs are of
      different length and thus far no one has been able to even them out.

PMID- 1031463
TI  - Immune response in dog 2 effect of dose of antigen on antibody production.
AB  - The primary antibody response of dogs and rabbits to both 'H' and 'O' antigens of
      Salmonella typhosa following intravenous injection with a formalin killed vaccine
      from 2.4 x 10(6) to 2.4 x 10(10) organisms/kg body weight was analysed. The
      animals were restimulated 80 days later with various vaccine concentrations. The
      lgM anti-'O' and lgG anti-'H' and 'O' antigens in the dogs, were significantly
      weaker in both primary and secondary response than the comparable rabbit group.
      Primary lgM anti-'H' response in the dog was found to be greater, equal, or less
      than that observed in the rabbit. A closer analysis of the primary response
      indicated that both animal species show the same latent period and doubling time
      in respect of anti-'H', and the differences observed are probably the result of
      the number of progenitor cells stimulated by the antigen. On the other hand the
      suppressed response of the dog to 'O'-antigen is the result of an overall weaker
      response of this animal to the antigen. The secondary anti-'H' lgM response was
      found to be greater than, equal to, or less than the primary response in the same
      animal. The significant inhibition of this response was observed in those animals
      which received a high primary dose of antigen.

PMID- 1031464
TI  - [Use of telethermography in patients with Holter's cerebrospinal fluid shunt].
AB  - The authors describe their experience with thermography in the study of the
      permeability of Holter's ventriculo-atrial shunt. Thermography has the advantage
      of permitting immediate visualisation and photographic documentation of the
      permeability. It appears that the thermographic findings show a good correlation
      with the functional state of the shunt in 88% of the cases examined. Causes of
      possible errors are discussed. It is concluded that thermography is a valuable
      method to assess the patency of Holter's ventriculoatrial shunt.

PMID- 1031465
TI  - [Cystic meningioma. An aspect of "forme humide" of Masson].
AB  - The presence of a no haemorragic cystic cavity in to a meningioma is a rare
      event. It has different pathogenetic mechanisms. It can sometimes, be the result
      of a wide necrotic area as it is frequently observed in the meningoblasomas that
      have had an extensive vascular developments. In our three cases the cystic cavity
      seems to be the result of a particular vacuolar and mixomatosa degeneration of
      the neoplastic tissue. Our cystic meningiomas are similar to damp meningioma of
      Masson.

PMID- 1031466
TI  - [Super-selective catheterization and embolization of the arterial pedicles of 2
      meningiomas of the posterior fossa].
AB  - In two cases with meningioma in the posterior fossa, the angiographic study,
      completed with the super-selective catheterization of the main pedicles, was
      followed by the technic of embolization. In the first case, a large meningioma,
      extending from the clivus to the left cerebello pontine angle, was supplied
      mainly by the ascending pharyngeal artery. In the second case, a huge meningioma,
      originating from the left inferior tentorial surface, was irrigated predominantly
      through the posterior branch of the middle meningeal artery and through the left
      occipital artery. Super-selective catheterization allowed us to better know in
      both cases the tumoral vasculature and to identify precisely the territory
      nourished by each supplying artery, from the external carotid artery.

PMID- 1031467
TI  - [Liquorrhoea and acute meningitis. Complications of a cerebrospinal fluid fistula
      secondary to a skull fracture suffered 45 years previously].
AB  - A case is described in which liquorrhoea and meningitis occur as complications of
      cerebrospinal fluid fistula. The patient incurred the initial skull fracture 45
      1/2 years prior to that. Three hypotheses as to the long interval are discussed.
      The authors propose to look for a cerebrospinal fluid fistula after every
      important trauma of the skull.

PMID- 1031468
TI  - [Psychologic aspects in the rehabilitation of patients with chronic pain].

PMID- 1031469
TI  - [Chemical neurolysis in the treatment of cancer pain].

PMID- 1031470
TI  - [Dorsal medullary decompression by double approach for paraplegia due to
      kyphosis].

PMID- 1031471
TI  - [The role of diastematomyelia in the differential diagnosis and treatment of
      kyphoscoliotic paraplegia].
AB  - By its frequent association with malformative scoliosis and neurological symptoms
      diastematomyelia has an important place in the diagnostic and treatment of
      cyphoscoliotic neurological syndromes. In all these cases and even in cases
      without neurological deficits the diagnosis of disatematomyelia should be done by
      routine myelography. The indication for operation is often curative in cases with
      neurological signs and prophylactic in those without.

PMID- 1031472
TI  - [Biochemical aspects of acoustic trauma (author's transl)].

PMID- 1031473
TI  - [Ultrastructural studies of stria "vascularis" of the Guinea pig (author's
      transl)].

PMID- 1031474
TI  - [Bowmann's glands (author's transl)].

PMID- 1031475
TI  - [Bacteriology and antibiogram in chronic otitis media (author's transl)].

PMID- 1031476
TI  - [Inverted papilloma of the sino-nasal tract (author's transl)].

PMID- 1031477
TI  - [Our experience in impedancemetry (author's transl)].

PMID- 1031478
TI  - [Brief notes in ophthalmology].

PMID- 1031479
TI  - [Amyloidoses in rheumatology].

PMID- 1031480
TI  - [Osteonecrosis and systemic lupus erythematosus. Case with 5 localizations].

PMID- 1031481
TI  - [Tendon ruptures in systemic lupus erythematosus].

PMID- 1031482
TI  - Distal blood pressure.

PMID- 1031483
TI  - Recommended method for the determination of creatine kinase in blood.

PMID- 1031484
TI  - Digital blood pressure in normal subjects and patients with peripheral arterial
      disease.
AB  - Systolic toe blood pressure was measured in 10 normal subjects and 17 patients
      with peripheral arterial disease during a warming and a cooling period, in which
      the skin temperature on the first toe was changed from 33 degrees C to 24 degrees
      C. In normal subjects systolic toe blood pressure increased from an average of
      110 mm Hg to 120 mm Hg during cooling (P less than 0.01), while the systolic arm
      blood pressure was unchanged during the study (125 mm Hg). Among the patients
      systolic toe blood pressure increased from an average of 56 mm Hg to an average
      of 70 mm Hg (P less than 0.01), while arm blood pressure increased from an
      average of 167/79 mm Hg during warming to 175/83 mm Hg during the cooling period.
      It is emphazised that despite the small, but significant, increase in digital
      blood pressure during the cooling period, changes in distal temperature will only
      have a small influence on the digital blood pressure, when one is evaluating
      patients with suspected or manifest peripheral arterial disease. In general,
      measurement during vasodilatation is to be preferred, since curves are easily
      obtainable.

PMID- 1031485
TI  - Digital blood pressure in patients with peripheral arterial disease.

PMID- 1031486
TI  - Reactive hyperaemia in the human calf after long-lasting ischaemia. A study with
      strain-gauge plethysmography.

PMID- 1031487
TI  - The influence of physical training during pregnancy on physical work capacity and
      circulatory parameters.

PMID- 1031488
TI  - Myocardial metabolism and performance during sodium salicylate infusion in dogs.
AB  - The effect of sodium salicylate on net myocardial free fatty acid (FFA) uptake,
      myocardial oxygen consumption (MVO2), and the mechanical activity of the heart
      was studied in eight intact, anesthetized dogs. Sodium salicylate was given
      intravenously under basal conditions and during isoproterenol-stimulated
      lipolysis. Under basal conditions, sodium salicylate significantly reduced
      arterial FFA concentration, but did not influence net myocardial uptake of FFA,
      and MVO2 was unchanged. During isoproterenol infusion sodium salicylate reduced
      arterial FFA concentration 28% (P less than 0.01) and significantly reduced net
      myocardial uptake of FFA from 44.5 +/- 9.0 (mean +/- S.E.M.) to 22.3 +/- 2.1
      mumol/min-100g tissue (P less than 0.05) and MVO2 from 20.3 +/- 2.2 to 160 +/-
      1.9 ml/min-100g tissue (P less than 0.05). The reduction in MVO2 could not be
      explained by reduced mechanical activity of the heart. Most probably the
      mechanism for the reduction in MVO2 effected by sodium salicylate during
      isoproterenol infusion was mediated by reduced myocardial FFA consumption.

PMID- 1031489
TI  - The influence of acetylsalicylic acid (aspirin) on gastric mucosal content of
      energy-rich phosphate bond.
AB  - The mucosal content of adenosine triphosphate, adenosine diphosphate and
      adenosine monophosphate in mini-pig corpus gland area and in pyloric gland area
      was examined after aspirin ingestion in acute experiments and after ingestion for
      several weeks. Ingestion of aspirin led to a statistically significant decrease
      of adenine nucleotide content in corpus gland and in pyloric gland area. An
      inverse correlation between the pH of the aspirin suspensions and the size of the
      decrease was established in the short-time experiments. In non-affected pyloric
      gland area mucosa and adenine nucleotide content was significantly lower than in
      the corpus gland area. Pyloric mucosa was more susceptible to aspirin-induced
      lowering of adenine nucleotide content than was the corpus mucosa. Prolonged
      aspirin ingestion led to statistically significant reductions of adenine
      nucleotide pool. The findings explain the decrease in mucous secretion and in
      acid secretion demonstrated in several studies. The finding of lower and more
      susceptible adenine nucleotide pool in the pyloric area might be the explanation
      for the preponderant occurrence of aspirin ulcerations in this region.

PMID- 1031490
TI  - Effects of different doses of acetylsalicylic acid on renal function in the dog.
AB  - This study was carried out in order to examine the effect of increasing doses of
      intravenously administered lysine-acetylsalicylic acid (ASA) on renal function in
      dogs. The first purpose was to examine the acute effects on renal water and
      solute output. The second purpose was to correlate the para-aminohippuric (PAH)
      clearance measurements with measurement of renal PAH extraction and renal blood
      flow (RBF). After 7 mg/kg ASA (20-80 microgram SA/ml plasma) a decrease in sodium
      excretion was observed in all dogs. With increasing ASA doses, the urine sodium
      excretion declined to 23% of the control period excretion. Tubular reabsorption
      of free water increased 10%. A significant and dose-related decrease in PAH
      clearance was observed in all dogs, from 108.7 ml/kg ASA to 58.8 ml/min after 200
      mg/kg ASA. The creatine clearance was unchanged. PAH extraction fell in all dogs,
      RBF (measured by flowmeter decreased 21% at the highest plasma SA levels, as
      compared with 46% decrease in PAH clearance. ASA seems to inhibit tubular
      transport of PAH. Inhibition of prostaglandin synthesis by ASA offers one
      explanation of the effects of RBF and sodium excretion.

PMID- 1031491
TI  - Effects of different doses of chlorpromazine on renal function in the dog.
AB  - This study was carried out to examine the effects of low 'alpha-blocking' and
      higher 'membrane-stabilizing' doses of chlorpromazine (CPZ) on renal function.
      CPZ was given at slow infusion rate either intravenously or into the left renal
      artery at three levels (0.5-1.0, 3-8, and 10-15 mg/kg) to 10 anesthetized dogs.
      An increase in plasma hemoglobin sometimes occurred within few minutes after
      infusion of more than 10 mg/kg CPZ, probably due to a hemolytic effect of such
      high doses. Systemic infusion of 0.5-1 mg/kg CPZ caused an increase in urine
      volume, sodium excretion, and renal plasma flow, and a decrease in filtration
      fraction and free water clearance was demonstrated in all dogs. At higher CPZ
      doses renal plasma flow increased further, whereas urine volume and electrolyte
      excretion were of the same order at all dose levels. A 21% decrease in tubular
      maximum para-aminohippurate transport (Tm(PAH)) was observed at the highest CPZ
      doses. After unilateral renal intra-arterial CPZ infusion the percentage change
      in urine volume, urinary sodium excretion, and Tm(PAH) were of the same order on
      the infused side as on the contralateral side. Even though the results at all
      dose levels can be explained by an 'alpha-blocking' effect of CPZ, possible
      membrane-stabilizine effects of CPZ cannot be excluded.

PMID- 1031492
TI  - Effects of androgens on oxygen affinity in vivo and 2,3-diphosphoglycerate
      content of red cells in peripheral arterial insufficiency.
AB  - The effect of testosterone on the red cell concentration of 2,3
      diphosphoglycerate (2,3-DPG) and on the in vivo oxygen affinity of venous blood
      was investigated. Six male patients with peripheral arteriosclerosis received 500
      mg testosterone enantas intramuscularly for 15 weeks. Six matched controls
      received 2 ml NaCl weekly for the same period of time. The hemoglobin
      concentration, the hematocrit, and the 2,3-DPG concentration increased
      significantly during testosterone treatment, while no significant changes in the
      oxygen affinity could be detected. It is concluded that testosterone in the doses
      applied here does not improve oxygen unloading from the blood.

PMID- 1031493
TI  - Differences between capillary and venous blood glucose during oral glucose
      tolerance tests.
AB  - The simultaneous capillary and venous blood glucose concentrations were measured
      during 36 oral glucose tolerance tests performed in 36 postmenopausal women.
      Three of the subjects had chemical diabetes mellitus. In samples obtained before
      and 120-180 min after the glucose load the differences between capillary and
      venous blood glucose concentrations were low, whereas samples taken after 15-90
      min showed a mean capillary-venous difference of 1.8 mmol/l. This is higher than
      previously stated by the World Health Organization and the British Diabetes
      Association. If the definitions that were recommended by these two bodies are
      used for defining whether the result of an oral glucose tolerance test is to be
      considered 'normal' or 'abnormal', the present results indicate that the verdict
      will in some cases be influenced by the route by which the blood was obtained.

PMID- 1031494
TI  - Radioimmunological determination and characterization of cathodal trypsin-like
      immunoreactivity in normal human plasma.
AB  - A radioimmunological method for determination of human cathodal trypsin-like
      immunoreactivity is described. DFP-treated human cathodal trypsin is used as
      standard and tracer. Freshly drawn normal human plasma contains about 25
      microgram/l of cathodal trypsin-like immunoreactivity measured as DFP-treated
      cathodal trypsin. The normally circulating cathodal trypsin-like immunoreactivity
      is shown to consist mainly of cathodal trypsinogen.

PMID- 1031495
TI  - Determination of bradykinin in blood by a sensitive radioimmunoassay.
AB  - Antibodies of high avidity (maximum Km 1.3 X 10(10) L/M) were produced in rabbits
      against bradykinin coupled to ovalbumin with toluene 2,4-disocyanate. Tyrosin8-
      bradykinin was labelled to a specific activity of 530-700 Ci/mmol with 125I by
      means of lactoperoxidase. Sensitivity of the radioimmunoassay was 0.01
      microgram/l blood. Specificity studies demonstrated the essential role of the C
      terminal arginine of bradykinin for binding to antibody. Mean recovery of
      [3H]bradykinin internal standard after the preparation of 86 blood samples was
      39.0%. The major loss occurred during ethanol precipitation. In venous blood
      collected at random conditions from 32 normal subjects the bradykinin
      concentration ranged 0.04-0.46 microgram/l and showed no sex difference.

PMID- 1031496
TI  - Radioimmunoassay of vasopressin in unextracted plasma.
AB  - A radioimmunoassay (RIA) for arg8-vasopressin (AVP) in unextracted human plasma
      was based on a sensitive anti-AVP rabbit antiserum, inhibition of enzymatic
      damage to [125I]AVP and AVP, and the use of an individual plasma blank, to
      correct for interference of plasma factors with the RIA. Sensitivity was 0.4 pg
      of synthetic AVP detected, corresponding to 1.2 pg/ml of AVP in human plasma.
      Recovery of AVP added to pooled plasma was 94 +/- 9.3% (mean +/- S.D.) in the low
      range (AVP, 2.8 pg/ml added) and 106 +/- 11.7% in the high range (45.0 pg/ml
      added). In 26 healthy, ambulatory subjects on ad lib, water intake, plasma AVP
      concentration was 2.0 +/- 1.22 pg/ml in the supine position and in 28 healthy
      subjects, 6.2 +/- 4.3 pg/ml in the upright position. Water loading suppressed the
      plasma AVP concentration. Smoking caused increased plasma AVP in 3 subjects
      despite water loading.

PMID- 1031497
TI  - Evaluation of the sampling technique and storage of blood using the B 109
      Arterial Blood Sampler syringe.
AB  - To evaluate the B 109 Arterial Blood Sampler (Radiometer), 10 different samples
      were analyzed for Pco2, Po2, and pH. The aerobic sampling technique, followed by
      storage for 2 h in water at 1 degrees C, induced small, but clinically
      insignificant, changes in the measured values.

PMID- 1031498
TI  - Cell reactions to metastatic tumors in the regional lymph nodes--light and
      electron microscopic studies.

PMID- 1031499
TI  - Arterio-jugular oxygen difference in severe intracranial lesions.

PMID- 1031500
TI  - Hearing impairment due to noise in the Kyung-In industrial area in Korea.

PMID- 1031501
TI  - Cytogenetic studies of the Korean chipmunk, Eutamias sibiricus asiaticus.

PMID- 1031502
TI  - A case of cryptococcosis treated with 5-fluorocytosine.

PMID- 1031503
TI  - Intranasal antrostomy with nasoantral window-plasty. (Kim's antrostomy).

PMID- 1031504
TI  - [Contour irregularities of the myelin sheath: ontogenetic study of the stato
      acoustic nerve].

PMID- 1031505
TI  - [Origin of afferent axons in the striate cortex of the albino rat: a study with
      horseradish peroxidase].

PMID- 1031506
TI  - Relation between corpus allatum and haemolymph proteins in Sphaerodema rusticum
      Fabr.
AB  - The active and inactive stages of the corpora allata have been described on the
      basis of size and nucleo-cytoplasmic ratio. The polyacrylamide gel disc
      electrophoresis of the haemolymph has been done in the males and different stages
      of reproducing females. A protein fraction with a value 14 less than or equal to
      Rm less than 16 has been observed only in females. Out of 8 protein fractions, 5
      showed oscillations in their concentration at the time of vitellogenesis. Finally
      active stages in the corpora allata are correlated with the fluctuations in
      haemolymph protein concentration.

PMID- 1031507
TI  - The role of hypertrophic cartilage in endochondral ossification.
AB  - Normal stages of histogenesis of long bones show that the hypertrophy of
      cartilage cells is the pre-requisite for the perichondrium to take up
      osteoblastic activity, (Fell 1925, Lutfi 1971). Cooper (1965) found the cartilage
      cells from epihysis of the long bones of chick failed to induce chondrogenesis in
      somites in mice and chick whereas flat cells and early Peripheral cells could do
      same. Fell and Landauer (1935) noticed that in avian phocomelia the hypertrophied
      cartilage cells fail to hypertrophy leading subsequently to deformities of long
      bones. Presently an attempt is made to analyse this process further by culture
      experiments. It is found that complete tibial rudiment or part of it grows
      normally in vitro with good differentiation of various zones and the development
      of osteoid tissue. However it is noticed that when cartilage and the associated
      perichondrial tissues are grown separately, there is no patterned growth of
      cartilage and the absence of development of osteoid tissue in either types of
      cultures. The role of perichondrium and cartilage is discussed in the light of
      experimental findings.

PMID- 1031508
TI  - Studies on the development of endocrine glands in fishes. I. Development of the
      hypothalamo-hypophysial neurosecretory system in Clarias batrachus L.

PMID- 1031509
TI  - The behaviour of the donor melanoblasts in the non-pigmented host embryos.
AB  - The behaviour of the donor melanoblasts from the leg bud mesoderm of Silver
      Campine implanted into White Leghorn embryos has been studied. Their schedule of
      migration from intracoelomic grafts to various parts of hosts is worked out.
      Different hypotheses for differentiation of grafted spherical melanoblasts in
      various tissues of hosts have been investigated.

PMID- 1031510
TI  - Developmental variations of the villi along the ileum in newly hatched and adult
      pigeons. A scanning electron microscopic study.

PMID- 1031511
TI  - Effect of luteinizing hormone on female Puntius ticto (Ham.).
AB  - Low doses (0.2 mg and 0.4 mg) of LH did not reveal any effect on the ovary of
      Puntius ticto (Ham.), but with 0.6 mg of LH the vitellogenesis began. Full
      maturation in the ovary was recorded with a total dose of 1.2 mg of LH and the
      fish spawned with a dose of 1.4 mg of LH.

PMID- 1031512
TI  - Ventral exocrine gland of larva of Spodoptera (Prodenia) litura (Fabricius)
      (Lepidoptera: Noctuidae).
AB  - The morphological and histological structure of the ventral exocrine gland of the
      larva of the tobacco caterpillar, Spodoptera (Prodenia) litura (Fab.) is shown.
      The proximal region of the gland is capable of protrusion through the prothoracic
      sternal slit as an elongate organ reaching upto the spinneret. The middle region
      of the gland shows characteristic giant cells in only one of the walls of the
      epithelium, while the distal region shows a thin flat epithelium with small round
      closely situated nuclei resting against the tunica propria. The gland probably
      secretes a gummy fluid for larval movements rather than a stinking odourous fluid
      for defense.

PMID- 1031513
TI  - Experimental quantitative electron microscopical studies on the nucleus lateralis
      posterior-pulvinar complex of the thalamus in the cat.

PMID- 1031514
TI  - Relationship of blood vessels to small intensely fluorescent cells in the
      autonomic ganglion.
AB  - In our experiments we observed the relationship of the blood vessels to the
      small, intensely fluorescent cells (SIF cells) in the lower mesenteric ganglion
      of the cat. We injected the solution of Evan's blue into the ganglia and
      processed them with the fluorescent histochemical method by Falck and Hillarp. We
      observed that the SIF cells are placed in the ganglia closely to the blood
      vessels or closely round them. When observing lager groups of SIF cells placed at
      the edge of the ganglia a dense network of the blood vessels was observed among
      these cells.

PMID- 1031515
TI  - [Afferent nerve endings in the small intestine and the stomach. Light and
      electron microscopic studies].
AB  - 1. In the mucous membrane of the duodenum and pylorus there have been identified
      free club- and tree like endings by ligth and electron microscopy. These endings
      lie flat between the muscularis mucosae and the glandular basis. 2. In the
      duodenum of the dog the receptors are undoubtly formed by myelinated axons. 3.
      According to neurophysiological results these free afferent endings are similar
      to PAINTAL'S (1957, 1963) mucosal mechanoreceptors.

PMID- 1031516
TI  - [Connective tissue in the perivascular spaces of subependymal capillaries of the
      spinal cord in the rabbit].
AB  - The normal structure of the subependymal capillaries and venules of the spinal
      cord was studied in rabbit. The endothelial cells of the capillaries and venules
      are surrounded by an irregularly formed perivascular space, about 0.5 to 3.3
      micrometer wide, which is delimited by an endothelial and glial basal lamina. The
      space contains a framework of collagen fibers. A period-acid-bisulfit
      aldehydthionine-method (Specht) permits to find the perivascular connective
      tissue lightmicroscopically, while they can be identified by electron microscopy.
      The significance of the perivascular connective tissue is open to discussion.
      Structural and functional problems have been reviewed in this context.

PMID- 1031517
TI  - [Enzyme histochemical studies of the general body surface apocrine glands in the
      domestic cat].
AB  - With enzyme histochemical methods, the distribution and the activities of various
      oxidative and hydrolytic enzymes in the apocrine glands of the general body
      surface of the domestic cat were investigated. The results obtained support the
      view that these glands are clearly active in function. On the whole, however, the
      relatively weak enzyme activities in the secretory portion of the glands point to
      only unimportant secretion production rates.

PMID- 1031518
TI  - Follicular and reticular arrangements of medullary cells in the adrenal gland of
      Gottingen Miniature pigs.
AB  - In the adrenal gland of Gottingen miniature pigs adrenaline- and noradrenaline
      storing cells showed follicular and reticular arrangements, which were not
      observed in the domesticated form (German land race) of Sus scrofa. Chromaffin
      cells could contain vacuoles, which were sometimes connected with follicles and
      filled with a material indistinguishable from that in follicles. Coated and
      smooth vesicles with contents of various electron densities were particularly
      abundant around vacuoles and Golgi areas, which were often found to be closely
      associated. Chromaffin cells were unconspicious with respect to other
      ultrastructural details. A comparison was made between this mode of arrangement
      and that seen after intense stimulation of the adrenal medulla using insulin,
      reserpine, or vinblastine. The possible significance of this particular pattern
      of arrangement of chromaffin cells is discussed.

PMID- 1031519
TI  - [Experimental studies of the size and distribution of mitochondria in giant
      boutons of the oculomotor nerve nucleus in Salmo irideus].

PMID- 1031520
TI  - Lysosomal disposal of secretory granules and their transformation into pigment
      particles in spontaneous prolactin cell adenomas of the rat pituitary.
AB  - Light and electron microscopic study of spontaneous prolactin cell adenomas,
      found at autopsy of 26 aging female Long-Evans rats and of 9 aging male Wistar
      rats, revealed pigment particles in the cytoplasm of some adenoma cells. It is
      postulated that most of the pigment particles derive from secretory granules. The
      presence of crinophagy and autophagy are interpreted as the morphologic
      expressions of lysosomal activation. The causative mechanisms accounting for
      lysosomal disposal of secretory granules and their transformation to pigment
      particles remain to be elucidated.

PMID- 1031521
TI  - Ultrastructural and cytochemical localization of calcium in a rat cardiac muscle
      in normal and experimental conditions.
AB  - The experiment carried out by us on the, stimulated by adrenaline, cardiac muscle
      allowed the activation of calcium localized mainly in the mitochondria, MA and FA
      of the intercalated discs and SR to be translocated in the direction of the
      sarcomere myofilaments and this especially to the thin actin filaments. The
      authors' experimental proves, that during the contraction--relaxation function of
      the cardiac muscle there exists a circulation rythm or a oscillatory functional
      flow of calcium ions between the mitochondria, intercalated discs and SR and the
      contractile fibrillae of the sarcomere.

PMID- 1031522
TI  - [The dorsomedial envelope in the human thalamus. A pigment architectonic study].
AB  - The shape and extension of the dorsomedial envelope (HASSLER 1959) in the human
      thalamus was examined in 800 micron thick slices stained with aldehyde-fuchsin.
      By means of selective staining of intracellular lipofuscin granules the pigment
      architecture of these grisea can be clearly depicted. The dorsomedial envelope
      consists of the nucleus cucullaris and the nucleus parataenialis. It covers the
      ventricular surface of the territorium mediale with an almost unbroken cellular
      layer stretching caudally as far as the nucleus pulvinaris superficialis. The
      strongly pigmented nucleus cucullaris can be seen as the main nucleus of this
      part of the envelope. It can be divided into three areas: nucleus cucullaris
      oralis, interpolaris, and caudalis.

PMID- 1031523
TI  - [Spermatogenesis in the yellow-bellied toad (Bombina variegata variegata L.)
      during the seasonal activity period and in correlation with the mating call
      activity (Discoglossidae, Anura)].
AB  - The spermatogenic tissue in the yellow-bellied toad Bombina variegata has certain
      properties not shared by other Central European anurans. Sertoli cells are
      lacking; the sperms are not bundled within the seminiferous tubules, but rather
      they form and mature in a connective-tissue follicle that is cellular in nature.
      Spermatogenesis is not a continuous process, at either the spermatocyte or the
      spermatozoa formation stage. Rather, there are periods of stagnation and of
      proliferation, which can be correlated with the periods during which the male
      toads produce mating calls and with the pauses between the calling periods. The
      crucial participation of hormonal factors in these processes is discussed.

PMID- 1031524
TI  - Studies on the seasonal histocytological changes in the internal and chromaffin
      cells of male Puntius sophore (Ham) in relation to its reproductive cycle.
AB  - An attempt has been made to correlate the activities of interrenal and chromaffin
      cells with the reproductive cycle of Puntius sophore. Chromaffin cells do not
      have any significant bearing while interrenal cells undergo qualitative and
      quantitative changes which have been correlated with the various phases in the
      reproductive cycle of this fish. These cells undergo degranulation and
      vacuolisation during spawning phase, disorganisation during regression phase, and
      reorganisation and gradual growth during resting and prespawning phases. These
      cells thus appear to play an important role in the reproductive physiology of
      this fish.

PMID- 1031525
TI  - [Histochemistry of cholinergic systems in the CNS. II. Topochemical and
      quantitative changes of cholinergic transmitter enzymes (AChe, ChAc) in the
      olfactory system of rats following midbrain lesions ].

PMID- 1031526
TI  - Further observations on the B-type neurosecretory cells in the thoracic ganglion
      of the crab, Potamon magnum magnum (Pretzman).
AB  - Only four types of the secretory neurones were observed in the thoracic ganglion
      of the fresh water crab, Potamon magnum magnum (Pretzman). These cells are
      classified as A, A', B and C types. Our results also confirmed that the B and B'
      types of cells (BAID et al. 1968) are one and the same type, the B cells. The B
      cells are of two forms, with and without the axons. They clearly showed
      sequential histological patterns pointing out to their phases. The secretory
      material is discharged either through the periphery or through the axon and
      periphery both. The vacuoles were observed in both the forms of the B cells. The
      remarkable sign of the activity of the nuclear membrane especially at the
      beginning of the secretory cycle and the appearance of the first secretory
      granules around the nucleus strongly support the vital role of the nucleus in the
      initiation of the secretory cycle.

PMID- 1031527
TI  - [Twins in nature, science, and society].

PMID- 1031528
TI  - Death-discordant twins--a new method to evaluate genetic factors in chronic
      diseases.
AB  - One of the most important lines of research on unselected large scale twin
      registries are mortality followups. Death-specific concordance rates have been
      calculated using different measures of concordance. These estimates are of great
      importance but they only reflect an "all or-none" classification of the genetic
      effect. It is suggested that mortality studies could be extended to, and include
      studies on, death-discordant twins. Such studies combine the advantages from
      mortality follow-ups on total twin populations with the detailed clinical
      investigation on subsamples. By examining the surviving cotwins with respect to
      various traits and supposed risk factors, an opportunity has been provided to
      study the genetic determination on the development of disease. This approach has
      been used in a study of ischaemic heart disease (IHD) and its risk factors in a
      representative subsample from the Swedish Twin Registry.

PMID- 1031529
TI  - Alcohol consumption in relation to factors associated with ischemic heart
      disease: a cotwin control study.
AB  - Moderately alcohol-discordant male twin pairs, aged 45-65 years, have been
      examined with respect to ischemic heart disease (IHD) and associated factors. No
      conclusion can yet be drawn with regard to manifest or subclinical IHD, while
      significant disparities were found with regard to systolic and diastolic blood
      pressures, high cigarette consumption, hyperglycemia, and serum cholesterol; the
      greater number of findings of pathological values were found in the high alcohol
      consumption as compared to the low alcohol-consumption cotwins. These findings
      offer a possible explanation for the increased number of reports showing a
      connection between high consumption of alcohol and occurrence heart disease.

PMID- 1031530
TI  - Attitudes towards twinning in primitive societies.

PMID- 1031531
TI  - Gene interaction in the phenotypic expression of mental diseases.
AB  - A genealogical analysis is carried out on the pedigrees of 10 twin pairs with two
      or more psychoses. The probands' symptoms reveal some peculiar aspects, i.e., an
      atypical phenomenology possibly due to the interference of more pathological
      genes. Schizophrenia, depression, epilepsy, and obsessive neurosis, are found in
      the pedigrees in different combinations. The study of these pedigrees would lead
      to the conclusion that interaction of more than one psychosis gives rise to
      atypical forms as a result of an attempt to establish a state of balance between
      opposing dynamic actions, as in reversible chemical reactions. Probands' symptoms
      are less severe and with an often more favourable prognosis. Epilepsy tends to
      become independent and the major psychoses seem to be epistatic on it. As for
      obsessive-compulsive neurosis, probands may progress into schizophrenia or
      depression if one of these psychoses is present in the pedigree, or may represent
      the neurotic form of the major disease.

PMID- 1031532
TI  - Twin studies in medical genetics.

PMID- 1031533
TI  - Major fetal hazards in multiple pregnancy.

PMID- 1031534
TI  - Twin pregnancy as a high risk pregnancy: new medical statistical data from the
      German Democratic Republic.
AB  - In 1972 the rate of multiple births showed a much more substantial decrease than
      in the years before. In the period 1963-1971 it dropped from 20.3% to 19.3% and
      in 1972 to 18.3%. The frequency of low birth weight in children from a multiple
      birth is 10 times higher than in all newborn children and the early neonatal
      mortality of children from a multiple birth is 8 times higher than that of all
      newborn infants. Cerebral damage is 30 times higher in children of low birth
      weight than in children of normal birth weight. In the period 1965-1967 perinatal
      death associated with cerebral damage (recorded on the death certificate)
      accounted for 5.7% of all children of low birth weight and for 0.2% of children
      weighing at birth over 2500 g. Early diagnosis of multiple pregnancy and early in
      patient care of women with multiple pregnancy will improve the development of
      multiple fetuses and give children from a multiple birth much better chances in
      life. In all twin studies it has to be considered that a relatively high
      proportion of twins is affected to a higher or lesser degree by cerebral damage.

PMID- 1031535
TI  - Early diagnosis and follow up of twin-pregnancy using a two-dimensional
      ultrasonic scanner.

PMID- 1031536
TI  - A case of simultaneous interstitial bilateral pregnancy.
AB  - Twin pregnancies may present tubal involvement in the following cases: (1)
      simultaneous intra- and extrauterine pregnancy; (2) interstitial bilateral
      pregnancy (either simultaneous or not); (3) multiple pregnancy in the same tube;
      and (4) simultaneous interstitial and ovarian pregnancy. Interstitial bilateral
      pregnancy appears to be by far the rarest kind of tubal twin pregnancy,
      apparently only one case having been reported in the literature, and this
      referring to a nonsimultaneous pregnancy. A case is now reported that therefore
      appears to represent the first observation of simultaneous interstitial bilateral
      pregnancy.

PMID- 1031537
TI  - Hypothesis of an ovular regulation of pregnancy weight-gain.
AB  - A retrospective study of 127 twin pregnancies has been carried out, considering
      the relation between maternal weight-gain and zygosity of the ovum. At 28 weeks
      of gestation, the maternal weight-gain distribution goes on according to a
      bimodal curve, the analysis of which shows that each pike corresponds to one twin
      pregnancy variety. Whatever the considered term might be (28-32-36 weeks), the
      maternal weight-gain is higher in DZ than in MZ pregnancies, and it should be
      pointed out that toxemic pregnancies, in each group, have nothing to do with this
      difference. This maternal weight-gain difference may reflect the known quality
      difference between MZ and DZ ova. The data lead to set up the more general
      hypothesis of an ovular regulation factor of the maternal weight-gain, in
      addition to classic data such as the own fetal weight, its annexes, and maternal
      diet.

PMID- 1031538
TI  - Leukemia in twins: antenatal and postnatal factors.
AB  - Two factors emerged from a search for obstetric phenomena that might explain
      concordance of leukemia in both members of a twin pair within days or months of
      each other: antenatal exposure to ionizing radiation; and antenatal cojoined
      intrauterine circulation. In addition, antenatal tumor metastasis and chromosomal
      changes, antenatal or postnatal, may be contributory. Continued observation of
      reports should be carried out.

PMID- 1031539
TI  - Supertwin records.

PMID- 1031540
TI  - Frequency of thoracoomphalopagus conjoined twins in Thailand.
AB  - Twenty-two cases of conjoined twins have been collected in Thailand. The numbers
      occurring in the various parts of Thailand are listed. No known cases have
      occurred between the years 1968-1973. The extent of union between the conjoined
      twins is described and illustrated. Some theories are offered as to etiological
      factors which might account for the occurrence of conjoined twins.

PMID- 1031541
TI  - Morphological and cytogenetic studies on conjoined twins.
AB  - Two cases of monoamniotic conjoined male twins, born at term after normal
      pregnancies, are reported. The first case, a bicephalus, shows hypoplastic and
      malformed left-side organs, absence of the left umbilical artery, and two
      communicating hearts, the left one with three cameras. The second case, a
      pygothoracopagus, consists in a twin "parasite", with no head but with two upper
      and two lower limbs, slightly less developed than those of the formed twin. The
      left eye of the formed twin is double than the right one and contains two eye
      apples -- one well-formed and the other rudimentary. There is a rudiment of a
      second mouth on the left cheek. The umbilical cord contains five blood vessels --
      one umbilical vein and four umbilical arteries. The cytogenetic study of the
      pygothoracopagus reveals aneuploidy, more pronounced in the "parasite" than in
      the formed twin.

PMID- 1031542
TI  - A case of conjoined twins.
AB  - Among 56,249 maternities in the Collaborative Perinatal Project, 615 were twin
      maternities. One of these resulted in stillborn thoracoomphalopagus MZ female
      twins with multiple cardiovascular, alimentary and other malformations. The case
      is of further interest in that the mother had a surgically removed brain tumor in
      childhood and exhibited neurological symptoms and bizarre behavior before and
      during pregnancy. Drugs and treatments which she received during pregnancy are
      not known to be teratogenic.

PMID- 1031543
TI  - Monoamniotic twins.
AB  - Six new cases of monoamniotic twins are reported. All had true knots of the cord,
      the result being double survival in 5 cases and 11 normal children. The mechanism
      of twin development is described and monoamniotic twins are placed in accordance
      with the two theories from the literature. A short review of both the
      Scandinavian and the world cases is presented.

PMID- 1031544
TI  - Familial twinning: a case for superfetation in man.

PMID- 1031545
TI  - Delayed ovulation and monozygotic twinning.
AB  - Aiming to show that delayed ovulation may induce MZ twinning, follicular
      maturation was induced in the rabbit by a small quantity of Pregnant Mare Serum
      Gonadotropin (16 UI four times): coitus, which induces ovulation in the rabbit,
      was delayed 60 hours after the last injection. From the 387 blastocysts obtained
      after this treatment, 6 (1.5%) were pairs of MZ twins, twinning being otherwise
      exceptional in the rabbit. Other anomalies were shown by the embryos, apparently
      related to a deficient quality of the eggs: high embryonic mortality (62% vs. 27%
      in controls) and chromosomal anomalies (20%) such as trisomies, triploidies, and
      chimaeras. The relation between MZ twinning, chromosomal anomalies, and embryonic
      mortality induced by delayed ovulation, could be connected and related to the
      poor perinatal conditions frequently observed in human MZ twins.

PMID- 1031546
TI  - Triplet pregnancy in a subfertile woman treated with clomiphene citrate.
AB  - A 26-year-old subfertile woman with a history of abortions at the 7-9th week was
      treated with Clomid, 50 mg for 5 days. A pregnancy resulted, which ended in the
      premature birth of a set of alive triplets that sex and blood-group
      determinations showed to be trizgotic. It is suggested that this production of a
      multiple ovulation in a woman with luteal deficiency be the result of excessive
      dosage of Clomid.

PMID- 1031547
TI  - Pathogenesis of acute pancreatitis: pancreatic ductal-interstitial-vascular and
      lymphatic pathways.
AB  - The generally accepted theory explaining the pathogenesis of pancreatic
      autodigestion (acute pancreatitis) is analysed. The pathways are discussed
      through which the content of the pancreatic duct system, the digestive enzymes,
      may escape to enter the acinar cells and the pancreatic interstices, together
      with the effect of the enzymes on the pancreatic vessels and thus on pancreatic
      blood flow. The potential consequences of vascular damage are described as well
      as the importance of pancreatic lymphatics in the transport of the escaped
      enzymes from the interstices. Although no definite answer can be given to the
      basic problem whether acute autodigestion of the pancreas is a result of some
      intra- or extra-acinar process, it is suggested that the intra- and extra-acinar
      processes are linked and are decisive in launching the pathological process.

PMID- 1031548
TI  - Effect of immunosuppressive therapy on the serum glycoprotein levels in chronic
      aggressive hepatitis.
AB  - The sera of 24 patients with chronic aggressive hepatitis receiving combined
      immunosuppressive therapy were studied for the concentrations of the carbohydrate
      components of glycoproteins and the IgG, IgA, IgM, alpha-2-macroglobulin,
      coeruloplasmin, beta-1-C-globulin and transferrin levels over a period of 2
      years. Liver biopsy was performed repeatedly in 50% of the cases. On the evidence
      of the results, combined immunosuppressive treatment is regarded as apt to
      normalize the serum concentrations of IgG, IgA, IgM and to reduce those of alpha
      2-macroglobulin and coeruloplasmin. Among the carbohydrate components of
      glycoproteins only the amount of hexose was reduced.

PMID- 1031549
TI  - Serum lipids and lipoproteins in chronic liver disease.
AB  - Serum cholesterol, triglyceride, total lipids and the lipoprotein pattern were
      studied in 169 cases chronic liver disease confirmed by biopsy. On the ground of
      the immunological and morphological results the patients were classified into
      five groups. In chronic persistent hepatitis no significant abnormality was
      found. In chronic aggressive hepatitis and in cirrhosis of the liver the serum
      cholesterol level was significantly reduced. In fatty infiltration of the liver
      the serum cholesterol, triglyceride and total lipid concentrations were
      significantly increased, as compared with the normal values and with the figures
      obtained in the cases of chronic inflammatory liver disease. In the cases of
      cirrhosis with additional diabetes the lipid values were likewise increased. In
      chronic aggressive hepatitis and in cirrhosis of the liver the levels of pre-beta
      and alpha lipoprotein were decreased, in fatty infiltration of the liver those of
      beta and pre-beta lipoprotein were increased.

PMID- 1031550
TI  - Carbohydrate metabolism in various types of hyperlipoproteinaemia.
AB  - Insulin secretion has been studied after an oral glucose load in 81 patients with
      primary hyperlipoproteinaemia and 15 control sugjects. Glucose tolerance was
      reduced mainly in Type IV, and to a lesser extent in Type IIB
      hyperlipoproteinaemia. Insulin secretory response to glucose was reduced in Type
      V and heterogeneous in Type IV hyperlipoproteinaemia. No correlation was found
      between the triglyceride level and the rate of insulin secretion.

PMID- 1031551
TI  - Diagnostic evaluation of gastric analysis (test meal) in Hungary.
AB  - On the basis of information received from 128 medical wards, the frequency of
      gastric analysis (test meal) used as a clinical diagnostic procedure, the
      spreading of the different methods and other problems connected with the
      examination are analysed. In about 3/4 of the institutions the test meal is
      performed in patients with all kinds of gastric complaint. This incidence
      decreases to 50% if the X-ray finding is positive. As acid-stimulants caffeine
      and a moderate dose of histamine are used most frequently. Of the data supplied
      by the test meal, the value for acid concentration (acidity) is registered by
      most of the examiners. The authors consider it as suprising that outdated methods
      such as a qualitative lactic acid assay (47%), isolation of Boas-Oppler's
      bacillus (25%) and of sarcinas (21%) are still in frequent use. The data are
      compared to the results of a similar survey made in England.

PMID- 1031552
TI  - Regulatory hyperparathyroidism: the role of C-cell hyperplasia.
AB  - Four cases with clinical and biochemical evidence of hyperparathyroidism are
      reported. The syndrome was due to DHT-intoxication of iatrogenic origin in the
      first case to histologically confirmed C-cell hyperplasia of the thyroid in the
      three others. The collective term "regulatory hyperparathyroidism" is porposed
      for the syndromes which, in distinction to secondary parathyroidisms, have a
      pathogenesis other than a negative calcium balance. Management of the syndrome is
      discussed with particular emphasis on the removal of the TCT-producing
      hyperplasia or adenoma, and the restoration of the electrolyte balance.

PMID- 1031553
TI  - Heart block: histological and clinical features.
AB  - The clinical types of A-V-block and the localization of the underlying lesion to
      the conduction pathway have been examined in 25 patients. On the evidence of the
      post mortem studies the lesions were of the following types: 1) Necrosis or
      fibrosis of ischaemic origin: 13 cases; 2) lesions of inflammatory character: 5
      cases; 3) nonspecific lesions; 6 cases; 4) malignant infiltration: one case.
      Correlations between the site of lesion and the clinical type and pattern of
      block could be demonstrated in a large proportion of the cases. The
      characteristic features of the individual types of block and their localization
      are discussed and a review of the literature is given.

PMID- 1031554
TI  - ECG changes in benzene, toluene and xylene poisoned rats.
AB  - Electrical activity of the heart was studied in acute, subacute and chronic
      benzene, toluene and xylene poisoning by means of NEK-2 type apparatus in CFY
      male rats. In the early period of acute intoxication benzene and its methyl
      derivatives, injected either intraperitoneally or subcutaneously or administered
      by inhalation did not cause changes in the ECG. Intravenously injected toluene
      induced a rapid and permanent decrease in blood pressure, in higher doses
      respiratory paralysis. In acute inhalation toluene and xylene poisoning the
      anesthesia was followed by respiratory paralysis, bradyarrhythmia and asystole,
      while inhalation of benzene induced respiratory paralysis followed by ventricular
      fibrillation. Subacute poisoning with benzene, toluene and xylene caused
      disorders in repolarization and arrhythmia. The degree, incidence and development
      of these phenomena depended on the dose and the duration of exposure. The effect
      of benzene influencing ECG was appreciably more intensive than that of toluene or
      xylene. Owing to the high number of spontaneous ECG changes due to ageing, it is
      difficult to evaluate the effect of chronic exposure to the agents under
      investigation.

PMID- 1031555
TI  - Modification of the biologic dose to normal tissue by daily fraction. Model for
      calculating normal tissue tolerance.
AB  - A method to predict normal tissue injury is proposed that includes high daily
      doses and unusual times successfully by calculating a new value called BIR
      (Biologic Index of Reaction). BIR and NSD were calculated for various normal
      tissue reactions. With the aid of statistical correlation techniques it is found
      that the BIR model is better than the NSD model in predicting radiation
      myelopathy and vocal edema and as good as NSD in predicting rib fracture. Neither
      model predicts pericardial effusion. In no case were the results  of BIR inferior
      to those of NSD.

PMID- 1031556
TI  - Anti-oestrogen therapy of advanced mammary carcinoma.
AB  - Forty mg daily of tamoxifen (Nolvadex) was administered orally to 89 patients
      with advanced soft tissue mammary carcinoma. At two months 43 per cent of the
      patients responded. At 6, 12 and 18 months, 42, 35 and 32 per cent, respectively,
      were still responding to therapy. The side effects were limited, fatique being
      the most frequent complaint. Oestrogen dependent side effects were not
      encountered. The therapeutic effect of tamoxifen is similar to that of oestrogen,
      but the side effects are less.

PMID- 1031557
TI  - Scanning electron microscopy of cells in the lymph of the human thoracic duct in
      advanced malignancies.
AB  - At scanning electron microscopy of cells from the lymph of the thoracic duct,
      collected by cannulation of patients with malignant tumours of different types,
      lymphocytes and red blood cells were found, but few malignant cells. The latter
      came from patients with pulmonary carcinoma and mammary carcinoma with lung
      metastases. Various abnormal shapes of the red blood cells were observed,
      possibly due to extrinsic factors such as administered drugs of abnormal
      metabolites from the malignant disease. The lymphocytes had no consistent
      pathologic shape, but appeared to act as immunologic, active cells against the
      malignant cells in the thoracic lymph.

PMID- 1031558
TI  - Radiation sensitizing effect of diamide on human cells cultivated in vitro.
AB  - Human cells of line NHIK 3025 were irradiated suspended in growth medium (E2a) in
      absence and presence of diamide under aerobic and extremely hypoxic (less than 4
      ppm O2) conditions. A sensitizing effect of diamide was found for doses exceeding
      8 Gy (800 rad) on cells irradiated under extremely hypoxic conditions in presence
      of diamide of concentration 200 micrometer, whereas no significant effect was
      observed for 20 micrometer.

PMID- 1031559
TI  - Histochemical and morphometrical changes in the adrenal glands in the course of
      circulatory failure.
AB  - The histological and biochemical changes in adrenal function has been studied in
      50 male cats with circulatory failure. The adrenal glands were examined by
      morphometric, histochemical and histoenzymological methods after a preliminarily
      study of the histoenzymological profile of the adrenal glands in intact animals.
      Five hours after hypotension induced by intravenous injection of trimethaphan and
      5 hours after a single massive bleeding, a decrease in adrenal function was
      observed. Adrenal insufficiency especially of the glucocorticoid release in the
      course of acute circulatory failure can be considered as a peculiar adaptation of
      the organism to preserve its life. The demonstrated decrease of adrenal function
      in the first hours of hypoxia may help in planning hormonal therapy under
      suitable conditions.

PMID- 1031560
TI  - Development of collagenous fibres in autologous and preserved homologous tendon
      grafts.
AB  - Collagen synthesis has been studied in preserved autologous and homologous tendon
      grafts, applied in dogs. The stages of collagen morphogenesis observed in the
      synthetizing fibroblasts appearing in the decomposing original structure of the
      transplants as well as in the extracellular ground substance are described. The
      results suggest that autologous tendon grafts and homologous ones preserved by
      irradiation, stored in cold physiological saline and beta-propiolactone, are
      rebuilt within eight weeks; meanwhile the original collagenous fibre structure is
      decomposed. When other preserving procedures such as deep-freezing or gamma
      irradiation are applied recomposition of the graft is retarded or fails to occur;
      the result is a cicatrizing adhesion.

PMID- 1031561
TI  - Selective sympathetic denervation induced by 6-hydroxy-dopamine in the small
      intestine.
AB  - The structure of the nerve fibres in the intact and neurally isolated intestine
      of the cat was studied after 6-OHDA treatment by fluorescence and electron
      microscopy. A gradual disappearance of green fluorescence in the monoaminergic
      fibers was observed. Degeneration of nerve fibres containing 30--60 nm agranular
      and 30--60 nm densecore (granular) vesicles could be seen in all layers of the
      small intestine. Sporadically, degeneration of the presynaptic elements occurred
      also in the synapses of myenteric ganglia. A large number of degenerating fibres
      could be observed in close relation to blood vessels. These were thought to be
      monoaminergic because 6-OHDA selectively affected their terminals. In the
      chronically isolated small intestine degenerated nerve processes could not be
      observed following 6-OHDA treatment. It is concluded that the intrinsic nerve
      elements do not contain monoamines. Accordingly, the previously observed yellow
      fluorescence of the nerve elements of the isolated small intestine might be due
      to some other kind of neurotransmitter, possibly tryptamine.

PMID- 1031562
TI  - Parenchymal destruction and arterial changes (haemodialysis intimal fibrosis) of
      glomerulonephritic kidneys in chronic intermittent haemodialysis.
AB  - The kidneys of 13 chronic diffuse glomerulonephritis patients who had been
      subjected to chronic intermittent haemodialysis were compared with those of 6
      patients treated in the conservative way. Their renal parenchyma was examined
      with a semiquantitative histological method and advanced complete destruction of
      the glomeruli was demonstrated in the dialysed cases. There was no perceptive
      difference in the distribution of the various grades of damage of the
      recognizable glomeruli and tubules. With the exception of the chronic lobular
      glomerulonephritis cases, a marked obliterative mucoid intimal proliferation
      ("haemodialysis-intimal-fibrosis") had developed in the dialysed
      glomerulonephritis patients. It affected the renal arteries of all size from the
      segmental to the interlobular arties. Haemodialysis-intimal-fibrosis did not
      develop in the additionally examined 13 dialysed chronic pyelonephritis cases nor
      in 8 such treated conservatively. The change seems to be characteristic, but not
      specific, for chronic diffuse glomerulonephritis treated by chronic intermittent
      haemodialysis.

PMID- 1031563
TI  - Reversibility and interaction with hepatic regeneration of toluene induced liver
      injury.
AB  - Acute and subacute toluene poisoning was induced in CFY rats. Routine
      histological, enzyme histochemical and electron microscopic investigations
      revealed that following discontinuation of exposure, the hepatic changes
      indicating an enhanced load on the detoxicating function (increased SDH activity,
      increase of mitochondria and smooth endoplasmic reticulum, decrease in Best
      carmine staining and PAS positivity) as well as degeneration (dilation of
      endoplasmic reticulum, accumulation positivity) as well as degeneration (dilation
      of endoplasmic reticulum, accumulation of autophagous vacuoles) show a rapid
      regression. The toxic effect of toluene and the functional load on the liver is
      thus reversible. In another series, toluene exposure was combined with partial
      hepatectomy. It has been established by routine histological, enzyme
      histochemical and electron microscopic techniques as well as by quantitative
      light and electron microscopic methods that the two interventions show a peculiar
      interaction: hepatic regeneration following partial hepatectomy inhibited the
      effect of toluene. On the other hand, the rate of regeneration was not influenced
      by toluene.

PMID- 1031564
TI  - Myeloid metaplasia in the spleen after acute haemolysis.
AB  - Copper sulphate, phenyl hydrazine and antiserum were administered to adult albino
      rats to produce equivalent haemolysis. Red pulp activity was studied for myeloid
      metaplasia after 24, 48 and 72 h, 5 and 7 days. Myeloid metaplasia was not
      related to the marginal zone proliferation. The activity rose rapidly with all
      the three agents and followed a similar curve despite the different patterns of
      haemolysis and erythrophagocytosis. Splenic erythrophagocytosis acts as a
      powerful feedback for splenic myeloid metaplasia. With copper, the release of
      reticulocytes and iron binding in haemoglobin is rapid as compared to the other
      agents, in spite of the initial lag phase, due to its effect on cellular
      metabolism.

PMID- 1031565
TI  - Frequency of juxtaglomerular granulated cells in the mouse kidney.
AB  - Studies of 23 untreated adult mouse kidneys revealed that in mouse kidney
      sections the frequency of juxtaglomerular granulated cells as compared to the
      glomeruli is 38.5 +/- 1.79%, the value for the JGI, 71.8 +/- 3.93. Following 100
      glomeruli through complete serial sections prepared from a single mouse kidney,
      it was shown that in the cortex of the mouse kidney all juxtaglomerular apparatus
      related to the glomeruli contain renin-producing modified smooth muscle cells
      with granulated cytoplasm.

PMID- 1031566
TI  - A glycoprotein precipitate in the blood vessels of kidneys stored in cold
      homologous blood.
AB  - Dog kidneys were stored three hours at 4 degrees C in heparinized homologous
      blood. Their histological examination revealed the presence of a homogeneous
      precipitate in the glomerular capillaries and afferent and efferent arterioles,
      and histochemical analysis indicated that it consisted of glycoprotein. It is
      tentatively suggested that the substance is cryoglobulin, a conclusion supported
      by the disappearance of the deposit on reimplantation of the kidney.

PMID- 1031567
TI  - Alterations of the Z-band in cardiac and skeletal muscles.
AB  - The heart muscle may react to various hypoxic damaging effects (e.g.N2, CO,
      haemorrhagic shock, electroshock) by identical responses similarly as in the case
      of skeletal muscle damages. One of the early manifestations of the process is the
      alteration of the Z-band, which is considered pathological. The alterations of
      the Z-band region precede the changes of the mitochondrial and sacrotubular
      systems and might form the morphological basis of functional changes induced by
      hypoxic effects. The alterations observed are differentiated from the hypertrophy
      of the Z-band. In the development of the alterations of the Z-band the role of
      other factors (e.g. calcium metabolism, sacroplasmatic membrane changes) is
      emphasized.

PMID- 1031568
TI  - The cytoarchitecture of the adrenal medulla in the rat.
AB  - The disposition of adrenaline and noradrenaline storing cells in the adrenal
      medulla has been studied in the rat. It has been demonstrated that no
      morphological or functional reason exists for the follicular designation of
      clumps of chromaffin cells in the medulla. No significant difference was found
      between the outer and inner zone as regards the frequency of NA cells by
      morphometric and statistical methods. The cytoarchitectural differences between
      adrenaline- and noradrenaline-storing cell arrangement are described. Special
      features of the interrelation between noradrenaline storing cells, cortical cells
      and the connective tissue framework are stressed. The light and electron
      microscopic appearance of two types of cortical cells, assumed to represent
      different states of functional activity is described.

PMID- 1031569
TI  - Central core in the spinal grey matter.
AB  - Golgi--Kopsch impregnated spinal cord sections of adult cats revealed a regular
      orientation of the dendrites in the intermediate region forming a circular or
      elliptical grey matter. The orientation of the dendrites is strictly transverse
      in the central core. A new interpretation of the spinal grey matter is proposed
      by viewing the dorsal, lateral and ventral horns (or columns) as crest-like
      appendages attached to the rod-like central core. A structural and possibly
      functional similarity between the central core and the brain stem reticular
      formation is emphasized.

PMID- 1031570
TI  - Intimate contact between human yolk sac endoderm and haemopoietic precursor
      cells.
AB  - Although the localization of embryonic haemopoietic cells in the endodermal
      epithelium of the human yolk sac had been discovered several decades ago, the
      nature and significance of the localization were dubious, and it was supposed
      that light microscopic pictures represent technical artifacts. Our
      ultamicrographs now demonstrate that at 16--26 mm CR-length there is an intimate
      contact between yolk sac endoderm and free haemopoietic precursor cells: apart
      from interdigitations various types of intercellular contact could be discovered.
      These contacts, especially the gap-like ones with associated electron dense
      cytoplasmic areas speak for intercellular communication, i.e., the role of
      endoderm in early human embryonic haematopoiesis appears likely. The
      demonstrability of these contacts, however, does not mean that endodermal
      associations are indispensable for haemopoietic differentiation.

PMID- 1031571
TI  - Blood supply of the rat hypothalamus. IV. Retrochiasmatic area, median eminence,
      arcuate nucleus.
AB  - The vascular supply of the rat hypothalamo-hypophyseal complex was studied by aid
      of a double injection technique (two dyes different in colour injected
      successively). The vascular bed of the median eminence, the arcuate nucleus, and
      the retrochiasmatic area are intimately interconnected among themselves, but
      isolated from the vascular system of all other parts of the hypothalamus. The
      arterial supply of this ensemble of the medial basal hypothalamus is common from
      the hypophyseal arteries, via the primary plexus and the specific vascular loops
      of the median eminence. From here a separation of the vascular bed leads the
      blood flow towards the pituitary portal vessels on the one hand, and over a
      subependymal vascular network towards the arcuate nuclei on the other. The venous
      drainage of the arcuate nuclei and the retrochiasmatic area is secured by a
      special set of tuberal and retrochiasmatic veins. --The unity of the vascular bed
      of the median eminence, arcuate nucleus, retrochiasmatic area complex, with a
      blood flow largely in the direction indicated by this sequence, is of
      considerable importance for the interpretation of the results of experimental
      interference with this region.

PMID- 1031572
TI  - [Peripheral nerve microsurgery and surgical treatment of hallux valgus
      (proceedings)].

PMID- 1031573
TI  - [Microsurgical technics in peripheral-nerve lesions (proceedings)].

PMID- 1031574
TI  - [Surgical treatment of hallux valgus (proceedings)].

PMID- 1031575
TI  - [Clinical and hematogenic considerations on 2 cases of cerebral venous thrombosis
      occuring during the use of oral estro-progestational preparations].
AB  - The authors illustrate the clinical peculiarities and the laboratory data of
      thrombotic accidents as complications of oral contraceptives and other estrogen
      containing drugs, concerning modern literature. Moreover, they describe two cases
      of cerebral venous thrombosis verified in Neuropathology Department of Maria
      Vittoria Hospital-Torino. The problem of prevention of these accidents is debated
      in the second part of the article.

PMID- 1031576
TI  - [Mandibular atrophy in edentulous persons].

PMID- 1031577
TI  - [Skin absorption (conditions of permeability, penetration, absorption of the
      skin)].

PMID- 1031578
TI  - [Studies at the Turin herbarium on the topic of phytotherapy as a substitution of
      insulin therapy in subjects with juvenile insulin-dependent diabetes].

PMID- 1031579
TI  - Light and electron microscopic studies of the gastrocnemius muscle in peripheral
      occlusive vascular disease.

PMID- 1031580
TI  - [Adrenal medulla of the mini pig: light and electron microscopy study].

PMID- 1031581
TI  - [Problems and medical aspects of antibiotic pharmacokinetics].

PMID- 1031582
TI  - [Bronchiolar and alveolar scanning with Au 198. Indicative evaluation of
      clearance time].

PMID- 1031583
TI  - [Radioisotope study for the better knowledge of various aspects of aerosol
      therapy].

PMID- 1031584
TI  - [Relationship between metabolism and pulmonary vasoactivity].

PMID- 1031585
TI  - [Hypercalcemia in pulmonary cancer: report of 5 clinical cases].

PMID- 1031586
TI  - [Terbutaline for oral administration: comparative functional study with other
      beta-2-stimulants].

PMID- 1031587
TI  - [Functional study of the bronchodilator effect of a new beta-2-stimulant
      (terbutaline) administered subcutaneously].

PMID- 1031588
TI  - [Pulmonary fibroma: report of a case and review of literature].

PMID- 1031589
TI  - [Clinico-radiological studies of a case of pulmonary aspergilloma].

PMID- 1031590
TI  - [Mediastinal opacity].

PMID- 1031591
TI  - [Kinetics of the binding 14C-DDT-and haemolymph lipoproteins of Periplaneta
      americana (author's transl)].
AB  - A study of the kinetics of the complexation of the 14C-DDT and lipoproteins of
      the haemolymph of Periplaneta americana (L.) was made, the method employed was
      that described by WINTER et alii (7). It was found that the above complex was
      unstable when kept at low temperatures (5 degrees) for more than twenty four
      hours; the incorporation of 14C-DDT in the proteic fraction increased with
      temperature up to 42 degrees C, and at least 6 hours of incubation were necessary
      to bind the 14C-DDT to the lipoprotein.

PMID- 1031592
TI  - [Analysis of nitrocompound pesticides by potentiography (author's transl)].
AB  - This paper describes a potentiographic technique developed for determining
      nitrocompound pesticides. The statistical analysis of the results showed that it
      is precise and accurate. Rapidity is another important characteristic of the
      developed potentiographic technique. It is not specific and for that in some
      cases a column chromatographic cleanup is necessary.

PMID- 1031593
TI  - [Neurobiology of human behavior].

PMID- 1031594
TI  - [Anatomical basis of behavior].

PMID- 1031595
TI  - [Hunger. Physiological mechanisms].

PMID- 1031596
TI  - [Memory and time perception].

PMID- 1031597
TI  - [The role of depression in human pathology].

PMID- 1031599
TI  - [Experimental analysis of behavior and its interrelations with neurobiological
      sciences].

PMID- 1031598
TI  - [Social changes of behavior. Drug addiction as an example].

PMID- 1031600
TI  - [Bioavailability and effect on myocardial function of a solution of digoxin in a
      soft gelatin capsule].

PMID- 1031601
TI  - [Pharmacodynamic and forced test of the atrial esophagocardiogram as to its
      subsidiary diagnostic value in mitral valve insufficiency].

PMID- 1031602
TI  - [Bioavailability of a solution of digoxin in a soft gelatin capsule].

PMID- 1031603
TI  - [Prognostic significance of sideremia in myocardial infarct].

PMID- 1031604
TI  - [Hemodynamic modifications induced by various bronchodilator agents administered
      intravenously in patients with chronic bronchitis].

PMID- 1031605
TI  - [Studies on the "sympathicotonic" orthostatic hypotension syndrome with
      bradycardia].

PMID- 1031606
TI  - [Suspected effect of environmental factors on the formation of abnormalities of
      intraventricular diffusion after stimulation].

PMID- 1031607
TI  - [A new catheter electrode with derivation for artificial stimulation].

PMID- 1031608
TI  - [A rare and abnormal ECG picture: changes in the rapid complexes in an uremic
      patient with marked hyperkalemia].

PMID- 1031609
TI  - [Comparative study of catecholamine excretion, vanilmandelic acid and 
      metanephrine in essential arterial hypertension: correlation with the pressure
      values].

PMID- 1031610
TI  - [Contribution to the pathogenesis and treatment of ventricular tachycardia with
      torsion of points].

PMID- 1031611
TI  - [Electrophysiological modifications induced by compression of the carotid
      sinuses].

PMID- 1031612
TI  - [Better therapeutic response and decrease of the collateral negative effects of 2
      hypotensive drugs (alpha-methyldopa and clonidine) obtained by means of their
      association].

PMID- 1031613
TI  - [Effect of the stimulation surface on the security factor in constant voltage
      pacemakers].

PMID- 1031614
TI  - [Comparative study of the hypotensive effect of a combination of oxprenolol
      chlortalidone with single and fractionated administration].

PMID- 1031615
TI  - [Treatment of hypertensive uremic patients in hemodialysis with beta blockers].

PMID- 1031616
TI  - [Contribution to the study of ischemic ventricular dyskinesia by means of
      kinetocardiography and the intravenous infusion of isoproterenol].

PMID- 1031617
TI  - [Effects of oxprenolol on the hemodynamic modifications induced by the stress of
      work].

PMID- 1031618
TI  - [A case of pre-excitation of the ventriculo-nodal fibers with double intranodal
      pathway].

PMID- 1031619
TI  - [Electrophysiological study of 4 cases of pre-excitation with an unusual course].

PMID- 1031620
TI  - [Chronological modifications of the His bundle conduction relative to frequency
      speed variations].

PMID- 1031621
TI  - [Functional response of the hypertensive decompensated heart to the removal of
      adrenergic effects].

PMID- 1031622
TI  - [Echocardiographic study of the left ventricular function in mitral valve
      stenosis].

PMID- 1031623
TI  - [Drug therapy and permanent endocardial stimulation in sick sinus syndrome: a
      study of 75 cases].

PMID- 1031624
TI  - [The left ventricle volume in mitral valve stenosis].

PMID- 1031625
TI  - [Hemodynamic and angiographic aspects of the mitral valve prolapse syndrome].

PMID- 1031626
TI  - [The isoproterenol test in mitral valve prolapse syndrome].

PMID- 1031627
TI  - [Methodological problems concerning the execution of the isometric test during
      heart catheterization].

PMID- 1031628
TI  - [Quantitative determination of mitral valve regurgitation].

PMID- 1031629
TI  - [Electrophysiological aspects of the anti-arrhythmic effect of bunaftine].

PMID- 1031630
TI  - [Study of the recovery time of the sinus node in sick sinus syndrome: importance
      and limits].

PMID- 1031631
TI  - [Changes in kidney function during hypotensive treatment].

PMID- 1031632
TI  - [Carotid baroreceptor reflex in normotensive subjects and hypertensive patients].

PMID- 1031633
TI  - [Electrocardiographic and vectorcardiographic modifications during pregnancy and
      post partum].

PMID- 1031634
TI  - [The behavior of plasma viscosity and of certain parameters of lipoprotein and
      glycoprotein during the initial phase of myocardial infarct].

PMID- 1031635
TI  - [Cardiac rhythm disorders and esophageal hiatal hernias].

PMID- 1031636
TI  - [Clinical experiences with hemodynamic treatment of ischemic heart disease].

PMID- 1031637
TI  - [Considerations on platelet aggregation inhibition in patients treated with
      acetylsalicylic acid].

PMID- 1031638
TI  - [Behavior of the euglobulin lysis time in diabetics with moderate
      arteriosclerosis subjected to various therapeutic treatments].

PMID- 1031639
TI  - [Pathogenetic and clinical considerations on a case of posttraumatic myocardial
      infarct].

PMID- 1031640
TI  - [Platelet aggregation in clinical medicine: value of Breddin's method].

PMID- 1031641
TI  - [Behavior of triglyceridemia in patients with carbohydrate intolerance subjected
      to an oral glucose load].

PMID- 1031642
TI  - [Euglobulin lysis time. I. Behavior in a group of young healthy subjects in
      relation to their relative body weight].

PMID- 1031643
TI  - [Radioelectrocardiographic control of early mobilization after myocardial
      infarct].

PMID- 1031644
TI  - [Behavior of digitalemia and of the systolic time intervals in cardiac patients
      after oral administration of beta-methyl-digoxin].

PMID- 1031645
TI  - [Morphology of experimental argyrosis in kidneys].
AB  - Prolonged per os administration of silver nitrate solution in rats will result in
      the development of experimental argyrosis with particles of silver in the kidneys
      being deposited mainly in the glomerular basal membranes. Apart from that,
      particles of silver in the glomeruli were also found in the mesangioma and, in
      minor quantities, in podocytes and endothelial cells. Outside the glomerular
      structures, silver was found deposited in tubular basal membranes, in the
      proximal tubule epithelium and minute vessel wals. -- A discussion is presented
      of the possible mechanisms involved in the development of such deposits, as well
      as of the relationship between intravital silver depositing and some of the
      tissues affinity to silver, a property taken advantage of in histological
      methods.

PMID- 1031646
TI  - [Experimental administration of a fatal dose of antiglomerular antibodies].
AB  - The administration of a sufficient dose of heterologous antibodies against renal
      glomeruli in rats produces symptoms of respiratory insufficiency and pulmonary
      oedema causing death of the animals. Under these experimental conditions the
      basic pathogenic mechanism appears to be binding of the injected antibodies on
      the basement membrane structures of pulmonary capillaries resulting in their
      damage. Such changes are followed by widespread haemorrhagic exsudative changes
      in the lungs. Localization of the injected antiglomerular antibodies has been
      studied with the aid of immunohistochemical methods and in addition, by a method
      using antibodies labelled with radioactive isotopes of iodine, the so-called
      "paired administration technique". After the administration of a lethal dose of
      antiglomerular antibodies, they later appeared to be predominantly localized in
      the lungs. This fact correlates well with the idea of the effect of the
      antibodies upon pulmonary parenchyma in the present experiment. A remarkable
      finding was a rather high localization of the injected antibodies in the liver
      parenchyma which could be explained either by a cross reaction between the
      antibodies and the antigens of hepatic vascular spaces, or by a shock reaction
      associated with heart failure and circulatory disturbances.

PMID- 1031647
TI  - [Functionally active tumor of the carotid body].
AB  - The clinical and biochemical pictures of a woman of 60 suffering from paroxysmal
      hypertension appeared to be clear evidence of a functionally active neoplasm of
      the sympathoadrenal tissue. A surgical operation ruled out the possibility of the
      tumour being localized adrenally so that the actual site of noradrenaline release
      was never found during the patient's lifetime. An autopsy discovered the presence
      of a carotid body tumor sized. 4.5X3X3 cm. The histological picture, electron
      microscopy as well as the positive isolation of noradrenalin all seemed to offer
      clear evidence of a functionally active tumour although the chromaffin reaction
      was negative. This is just additional evidence of the fact that the carotid body
      does belong among sympathetic paraganglia and that the chromaffin reaction is not
      sufficiently sensitive and reliable either for the determination of biogenic
      amines in the tissue or for a clear, unequivocal detection of functionally active
      tumours of the sympathetic.

PMID- 1031648
TI  - [Cardiomyopathy in progressive muscular dystrophy].

PMID- 1031650
TI  - Rhinoplasty results.

PMID- 1031649
TI  - [Kinetics and morphology of immune reaction cells in the spleen studied using the
      immuno-cyto-adherence reaction. V. Secondary response and its modification by
      whole-body irradiation at different intervals following administration of
      antigen].
AB  - Observations were made of the course of secondary immunological response, using
      the immuno-cyto-adherence method under the influence of 450 r general body
      irradiation on murine spleen following secondary ram erythrocyte immunization.
      Irradiation was applied 24 hours, 72 hours and 6 days after an i.p.
      administration of antigen. Irradiation was immediately followed by an absolute as
      well as relative drop in RFC number and by an overall drop in splenic cell
      number. In case of irradiation applied prior to reaching the secondary reaction
      quantitative maximum, there was a development of the increment and another RFC
      quantitative maximum was reached between days 15--20 after irradiation. Small and
      medium size lymphocyte values were seen decreasing immediately after irradiation.
      Where irradiation took place prior to reaching the quantitative maximum of a
      normally proceeding anamnestic reaction, large lymphocytes constituting RFC were
      increasingly represented after a certain period of stagnation or even without it.
      Plasmatic series cells on irradiation tended to  increase their total share to
      become a prominent cell element after delayed quantitative RFC maxima had been
      reached and to reach complete predominance towards the end of the period of time
      under observation. A relative increase in the proportion of macrophages was seen
      immediately after irradiation.

PMID- 1031651
TI  - Mastoid surgery: the swing of the pendulum.

PMID- 1031652
TI  - Rehabilitation of the voice after pharyngolaryngectomy and skin repair. I.
      Cineradiography.
AB  - Eleven patients who had undergone pharyngolaryngectomy and who had poor or no
      speech were studied to find out why. An absent oesophageal stripping wave and the
      presence of a 'sump effect' are described. It is concluded that these are two
      positive anatomical factors mitigating against the acquisition of oesophageal
      speech in pharyngolaryngectomized patients.

PMID- 1031653
TI  - A morphometric study of the laryngeal saccule and sinus.
AB  - A morphometric study of 111 larynxs from both sexes was performed with the
      initial intention of assessing the incidence of asymptomatic laryngeal pouches.
      Certain basic measurements were made also to determine the dimensions of the
      laryngeal saccule and sinus relative to the height and width of the larynx in the
      two sexes. Asymptomatic pouches were found in 2 patients, one from each sex and
      there was no obvious difference in the height of the saccule relative to the
      height of the larynx in the two sexes. However, since the male larynx was deeper
      in the anteroposterior plane relative to its height, the male saccule tended to
      be relatively shallower than the female.

PMID- 1031654
TI  - Late recurrence or radiation induced cancer of the larynx.
AB  - Twenty five patients with squamous carcinoma of the glottis (T1a and T1b) had
      undergone successful irradiation. Many years later they developed a so-called 
      late recurrence. The following evidence shows that these 'late recurrences' are
      radiation induced: the interval of 5-18 years (mean 9.9 years) between the first
      and the second cancer correlates with the interval seen usually in radiation
      induced malignancy, recurrences generally appear during the first 2 years after
      irradiation, all the second cancers were found in the previously irradiated area,
      in patients treated by surgery only, late recurrences are extremely rare,
      histological examination clearly shows that the second carcinoma originates from
      the squamous epithelium and not from dormant nests in the deeper layers of the
      vocal cord. These factors should be taken into consideration when deciding
      between surgical or radiation therapy in younger patients with high life
      expectation.

PMID- 1031655
TI  - The place of cytology in laryngeal diagnosis.
AB  - A cytological procedure providing useful supplementary information in the
      diagnosis of laryngeal malignancy is described. Of 51 patients, 22 had complete
      correlation with histological examination in confirming a benign condition.
      Twenty patients had complete correlation in confirming a malignant lesion. Five
      patients showed cellular atypia in the presence of benign conditions. Three
      showed atypia, of which 2 were malignant, 1 being unstable histologically but
      with no evidence of frank malignancy. Ten patients had been irradiated
      previously; in all cases the distinction between residual disease and no evident
      disease was correctly diagnosed with respect to the histological appearance.

PMID- 1031656
TI  - Cardiac arrest in otorhinolaryngology.
AB  - A study has been carried out of 42 episodes of cardiac arrest related to 90 000
      otorhinolaryngological operations. The basic pathology, factors precipitating the
      arrest, and the results of treatment are analysed. Clinical areas presenting
      special problems are the surgery of cancer of the postcricoid area, deliberate
      hypotension, anaesthesia for laryngoscopy and respiratory obstruction.

PMID- 1031657
TI  - Temporary threshold shift and the auditory evoked response. A preliminary report.
AB  - A preliminary study was performed on 5 normal subjects to investigate and compare
      the reduction and recovery of the auditory evoked response (AER), and to compare
      this with the temporary threshold shift (TTS) that occurs with fatiguing sounds.
      The findings are discussed in relation to the basic nature of the AER.

PMID- 1031658
TI  - Facial spasm.
AB  - There are many varieties of abnormal facial movement. This paper discusses
      hemifacial spasm and blepharospasm in particular. A technique found useful for
      the symptomatic relief of idiopathic hemifacial spasm is described, and
      experience with its use on 15 patients also described. Experiences in the
      operative treatment of 6 patients with essential blepharospasm are recounted.

PMID- 1031659
TI  - Transtympanic electrocochleography in the diagnosis of retrocochlear tumours.
AB  - Transtympanic electrocochleography has been used as a diagnostic procedure in
      over 250 adult patients with sensorineural deafness. No complications have been
      encountered. Among these patients vestibulocochlear Schwannoma (acoustic neuroma)
      has been confirmed in 56 ears while 11 other ears have been found to be affected
      by other space-occupying lesions. As a result of our observations in these
      patients, we would like to propose that there are at least three separate
      criteria to be considered in reaching or strongly suspecting a diagnosis of such
      pathology. These are broadening of the action potential (loss of P1), observation
      of a clear microphonic response, and preservation of the action potential even
      when using stimulus intensities which are not audible in the patients' affected
      ears. The merits of each of these criteria are discussed and compared with other
      clinical and operative findings. With the electrocochleographic techniques now
      employed in searching for acoustic neuromas, false negative results are rare
      though false positive results are still obtained.

PMID- 1031660
TI  - Growth rate and recurrence of residual epidermoid cholesteatoma after
      tympanoplasty.
AB  - One hundred and forty-one consecutive patients with chronic otitis media and
      cholesteatoma treated mainly by open surgical techniques between 1965 and 1972
      were studied to investigate the phenomenon of residual cholesteatoma. The average
      rate of emergence of residual cholesteatoma was 0.25% of the cases per month
      during the first 5 years, after which the rate of discovery almost ceased.
      Observed cumulative frequencies of recurrence were 1.4% at 10 months, 14.9% at 5
      years and 17.0% at 8.3 years postoperatively. The null hypothesis of no apparent
      predilection of cholesteatoma for recurrence at any one site was retained.
      Parameters of growth rates of epidermoid cysts arising from residual
      cholesteatoma were estimated. Epitympanic cysts grew fairly rapidly, doubling in
      diameter every 10 months. Mastoid cysts were slower, doubling in diameter every
      25 months. Results for the mesotympanum were inconclusive. The practical
      implications of this information for the management of future cases is discussed.

PMID- 1031661
TI  - Percutaneous teflon injection of a vocal cord under fibre optic laryngoscopic
      control.
AB  - The technique of percutaneous injection of Teflon paste into a paralysed abducted
      vocal cord using a fibre optic laryngoscope to observe and control the effect is
      described. Its use in vocal cord paralysis caused by inoperable bronchogenic
      carcinoma and the results in 14 patients are discussed.

PMID- 1031662
TI  - A second method for induction of a transmissible entity in the control of cancer
      in mice.
AB  - Spontaneous tumour-bearing mice of the C3H/St and subline C3HB/St inbred strains
      received injections of three nucleosides, adenosine, 6-methyl adenosine, and 5
      methyl cytidine, prepared in the same molecular concentration as they had
      occurred in an alcohol-soluble liver extract which in previous work had
      suppressed tumour growth. Two transmissible entities appear to be present and
      they show different degrees of effect upon the growth and regression of
      spontaneous tumours of mammary gland origin (adenocarcinoma). The first
      transmissible entity (TE) occurred in the lineal descent of mice following
      injection of the liver extract. The second entity (TE2) appeared following
      injection of 5-methyl cytidine. TE manifested its maximum effect in suppressing
      cancer in mice during the 20th generation of a lineal descent following the
      injection of the original liver extract into a mother of the cancer proband. TE2
      appears to be optimal in controlling cancer in the F11 generation of a second
      lineal descent derived from an original cancer proband of the C3H/St inbred
      strain injected with 5-methyl cytidine.

PMID- 1031663
TI  - Salivary gland chromosomes of Lucilia cuprina (Diptera, Caliphoridae).
AB  - The salivary gland chromosome complement in Lucilia cuprina consists of five
      pairs of autosomes and two sex chromosomes X and Y, all with characteristic
      banding patterns. A standard map for the salivary gland chromosomes of this
      species has been prepared, and compared with the known map of Lucilia cuprina
      dorsalis from Australia. The differences in their banding patterns indicate the
      existence of different varieties within the same species.

PMID- 1031664
TI  - Ultrastructural and physiological changes induced by atractylate in the canine
      myocardium.
AB  - The myocardial cellular response to the cardiac glycoside atractylate, a known
      inhibitor of mitochondrial adenine nucleotide translocation, was examined
      physiologically, morphologically, and morphometrically in eight dogs. An isolated
      in situ segment of left ventricular tissue was employed in these experiments to
      eliminate collateral flow and the potential for large sampling error. It was
      found that atractylate infusion rapidly induced physiological and morphological
      changes suggestive of a loss of membrane regulation of ion flux in the arteriole,
      capillary endothelium, and myocardial cell. Also mitochondrial changes suggestive
      of adenine nucleotide translocase inhibition were observed. As these responses
      are similar to those induced by acute myocardial ischaemia, it is suggested that
      ischaemia and atractylate induce cell injury by similar mechanisms.

PMID- 1031665
TI  - Is extrasensory perception extrasensory?

PMID- 1031666
TI  - Clinical drug information profit or knowledge orientated.

PMID- 1031667
TI  - The metabolism of testosterone in the brain: the occurrence of delta4-3
      ketosteroid 5 alpha-oxidoreductase and 3alpha-hydroxysteroid dehydrogenase and
      the effects of central acting drugs on these enzyme activities.

PMID- 1031668
TI  - [Oxytocic activities in human pituitary gland on sudden death (author's transl)].

PMID- 1031669
TI  - [Identification of adrenal tumor by ultrasonic tomography (author's transl)].

PMID- 1031670
TI  - [1. Recent development of endocrinology. 2. Present status of pituitary diseases
      in Japan].

PMID- 1031671
TI  - [Insect hormones].

PMID- 1031672
TI  - [Reinvestigation of hyperglycemic response to glucagon and the effect of glucagon
      on blood cholesterol and triglyceride concentrations. (2) Changes in liver
      disease (author's transl)].

PMID- 1031673
TI  - [New bioassay method for measurement of angiotensin II (author's transl)].

PMID- 1031674
TI  - [Postnatal development of the adrenal gland in the rat (author's transl)].
AB  - Postnatal development of adrenocortical function of rats was studied. During the
      first week after birth the increase in adrenal weight was very slight.
      Consequently, the relative weight of the gland per body weight decreased
      progressively during the postnatal 14 days. However, adrenal corticosterone
      concentration showed a gradual elevation over this period of postnatal days.
      Adrenal corticosterone response to ether stress did not appear in male rats at 12
      days of age, but a distinct response was observed in female ones at the same age.
      A sex difference in the duration of the stress-nonresponsive period is likely to
      exist in newborn rats. In accord with the stress-nonresponsive period, the thymus
      lymphatic system showed a marked development. The pattern of circadian
      periodicity of plasma corticosterone levels in 21-day-old rats was somewhat
      different from that in adult rats. Peak value of the corticosterone rhythm was
      attained at 0300 in the infant rats. A sex difference was again noticed in the
      evening rise of plasma corticosterone level in these infant rats: the rise was
      steeper in females than in males. A significant circadian periodicity was
      observed in female rats at 14 days of age, but the periodicity was equivocal in
      male ones at the same age.

PMID- 1031675
TI  - [Atrophy of adrenal gland and thymus following cortisol treatment in newborn rats
      (author's transl)].
AB  - Effects of neonatal treatment with cortisol on the mortality, growth rate, the
      weight of thymus, spleen and adrenal gland, blood lymphocyte counts and stress
      responses were examined in the rat. In rats treated with 1 mg cortisol the
      survival rate was only 13 percent, and in those given 0.75 mg the rate was 47
      percent. Large doses of cortisol produced "wasting syndrome" and the animals died
      during a period from 5 to 13 days after the injection. Over the first week the
      body weight did not increase in rats injected with cortisol in doses of 1 and
      0.75 mg. A marked atrophy of the thymus and a great reduction of the blood
      lymphocyte counts were observed in rats treated with large doses of cortisol. The
      development of spleen was temporarily inhibited. The adrenal gland was remarkably
      atrophied: the gland weight at 21 days of age was similar to that at birth and
      only 22 percent of the control value. In rats injected with 0.5 mg cortisol
      plasma corticosterone response to ether inhalation was not different from that of
      normal controls at 21 days of age. However, rats treated with 0.75 and 1 mg
      cortisol did not show plasma corticosterone response on exposure to a strange
      environment. The effect of several kinds of corticoids was also examined.
      Dexamethasone and betamethasone caused a marked atrophy of the thymus and spleen.
      Cortisol and deoxycorticosterone produced a large decrease in the adrenal
      corticosterone content. The effect of exogenous corticosterone was less in extent
      as compared with that of cortisol.

PMID- 1031676
TI  - [Metabolic fate of synthetic glucocorticoids in the rat].

PMID- 1031677
TI  - The use of fibroblast and epidermal growth factors to lower the serum requirement
      for growth of normal diploid cells in early passage: a new method for cloning.
AB  - The proliferation of animal cells in tissue culture requires unidentified
      macromolecules that are contained in serum. Since serum is an extremely complex
      mixture, efforts to purify these growth-promoting components of serum have met
      only limited success. On the assumption that these growth-promoting
      macromolecules in serum are synthesized in active form in some tissue other than
      blood, we investigated the possibility that they may be purified more readily
      from specific organs than from serum. We have concentrated our efforts on two
      likely sources: the pituitary gland, since partially-purified preparations of
      pituitary hormones have been reported to stimulate the growth of cells in vitro
      and brain, since neural tissue is essential for the regrowth of amputated limbs
      in lower vertebrates capable of regeneration. Both pituitary and brain have
      yielded a strongly mitogenic polypeptide that we call Fibroblast Growth Factor
      (FGF). FGF was named on the basis of early studies demonstrating its effect on
      fibroblastic cells: 3T3 cells, amniotic fluid-derived cells, and fibroblasts from
      human foreskin and mouse embryos. Further work has revealed that FGF promotes the
      growth of several other mesoderm-derived cell types including adrenal cells,
      chondrocytes, myoblasts, vascular smooth muscle cells, and vascular endothelial
      cells. The effect of FGF will be compared to that of EGF and its use for cloning
      mammalian cells will be described.

PMID- 1031678
TI  - Large-scale cultivation of cells in closed systems: stationary and moving.
AB  - Basic metabolic differences have been observed for cell cultures propagated in
      conventional stationary or rotating systems. The influence of these differences
      on virus characteristics is largely unknown but could be significant in
      maintenance of genetic stability of attenuated strains. Current requirements for
      good manufacturing procedures prompted the development of closed systems for both
      stationary and rotating cultures. Both are suitable for large-scale virus
      production. The methods will be described along with data on yields of a number
      of vaccine viruses.

PMID- 1031679
TI  - The large-scale cultivation of diploid cell strains in microcarrier culture.
      Improvement of microcarriers.
AB  - The use of diploid cell strains for virus vaccine production is mostly retarded
      by the inefficient culture techniques used for the propagation of these cells.
      The microcarrier culture system might be a good solution for this problem. DEAE
      gels appear to be the most satisfactory microcarrier. The best results are
      obtained by using DEAE-gels with a rather low anionic exchange capacity or at
      higher capacity after coating with polymers.

PMID- 1031680
TI  - Development of a perfusion culture system for production of biologicals using
      contact dependent cells.
AB  - Design and evaluation of a new type of culture vessel for contact dependent cells
      is described. Cells are grown on both sides of stationary glass plates in a
      laminar flow of medium supplied from separate reservoirs. Construction and
      operation of vessels ranging in growth surface from 0.02 to 10 m2 is relatively
      simple and there are no moving parts. Cells can be inspected by low power
      microscopy in the usual way. Evaluation of this equipment was carried out using
      the human diploid cell line MRC-5. Saturation densities of up to 1 million cells
      per square centimetre of growth surface were obtained where appropriate medium
      volumes were used. Application of this sytem to other cell types and the
      production of biological products is briefly discussed.

PMID- 1031681
TI  - Updated results on the karyology of the WI-38, MRC-5 and MRC-9 cell strains.
AB  - Data concerning cumulative results obtained from studies of the karyology of the
      characterized MRC-5 cell strain and the MRC-9 strain at present being
      characterized, indicate that these cells have karyological characteristics
      similar to each other and to the extensively studied WI-38 cell strain. The
      general inference from these studies is that the cells are karyotypically stable
      and that their karyological characteristics are within the limits recommended for
      normal cell populations.

PMID- 1031682
TI  - Reappraisal of karyological monitoring of diploid cell substrates.
AB  - The practical aspects of present requirements for karyological monitoring of
      diploid human fibroblasts used in vaccine production are critically re-examined.
      A brief review of known chromosomal instabilities and their correlations with
      neoplasia and with in vitro conversions of cell growth is presented and discussed
      in relation to karyological criteria in the selection of mammalian diploid cell
      substrates. It is proposed that extensive experience with the growth and
      karyological characteristics of human diploid fibroblast cell strains of
      embryonic origin may warrant the reduction or elimination of karyological
      monitoring of production lots. Additional requirements for characterization of
      cell strains for approval as substrates for vaccines are suggested which involve
      evaluations of chromosomal stability based upon (a) viral transformation rate and
      (b) aberration production rate in response to x-irradiation.

PMID- 1031683
TI  - Observations of the incidence of structural abnormalities in the chromosomes of
      WI-38 cells prepared for vaccine manufacture.
AB  - Chromosome monitoring of 500 batches of WI-38 cells prepared for vaccine
      manufacture involved examining 50-60,000 metaphases at p31-32. Results collected
      over 6 years showed the mean incidence of aneuploidy and breaks to decrease
      slightly, whereas the incidence of structural abnormalities followed a sharply
      rising trend, eventually reaching a level where a substantial proportion of cell
      batches exceeded the limit set for this parameter for vaccine substrates. No
      technical or cultural factor accounted for the trend which appeared to be
      correlated with the date of receipt of the seed ampoule. The confidence limits
      set for this parameter in 1971 were regarded then as provisional. It is suggested
      that in the light of the observations reported, the position should now be
      reconsidered.

PMID- 1031684
TI  - Karyological characterization of WI-38 cells used in the production of vaccines.
AB  - According to the valid requirements, samples of WI-38 cells taken prior to the
      final subcultivation for vaccine production by the manufacturer, were
      reconstituted, subcultivated and investigated in our control laboratories.
      Chromosome monitoring was done using permanent orcein stained slide preparations
      for direct evaluation and photographs of all selected cells for exact counts,
      scoring for breaks and karyotype analysis in the case of abnormalities. The
      tabulated summary of karyological analyses on more than 2000 cells shows that
      with one exception, the chromosome abnormalities did not exceed the upper limits
      of karyological acceptability. Photographs of abnormalities detected are
      presented as well as metaphases and reconstructed karyotypes. Our data are
      compared with those provided by the manufacturer. Obvious discrepancies in the
      frequency of abnormalities might be due to higher passage levels of the identical
      cell material tested by us and to slight differences in the methods of
      preparation and evaluation.

PMID- 1031685
TI  - The need for non-cultural methods for the detection of mycoplasma contaminants.
AB  - Mycoplasmas are common contaminants of cell cultures and are of great importance
      because of the deleterious effects they have upon the infected host cells.
      Routine detection testing usually relies upon cultural methods and demonstration
      of characteristic colonies on agar. Questions as to the efficacy of this method
      have been raised because of increasing realization of the presence of "non
      cultivable" mycoplasmas. Several non-cultural detection methods have been
      developed to aid in the detection of these fastidious microorganisms. These
      methods include morphology by light and electron microscopy, immunofluorescence,
      enzyme assays, autoradiography, sucrose gradient separation, altered transport of
      nucleic acid precursors and altered nucleic acid profiles. A comparison of the
      relative sensitivities of these methods will be outlined. The need for, and the
      feasibility of non-cultural detection methods as quality control tests in human
      virus vaccine production will be discussed.

PMID- 1031686
TI  - Tumourigenicity testing in immunosuppressed mice: advantages and disadvantages.
AB  - Optimal conditions for the detection of malignant cells substrates were
      investigated. Three approaches were used: (1) neonatally thymectomized,
      antithymocyte serum (ATS) treated mice, (2) thymectomized, lethally irriadiated,
      bone marrow reconstituted (T-B+mice, and (3) congenitally athymic nu/nu (nude)
      mice. All three systems successfully distinguished between normal and malignant
      cell lines. However, differences were observed between different colonies of nude
      mice as to their capacity to support progressive growth of certain tumours.
      Advantages and disadvantages of the immunosuppressed mouse model system will be
      discussed. They will include: (a) detection of malignant cells in mixed
      populations, (b) need for different routes of inoculation for different cell
      types, (c) comparison with other malignancy testing systems, (d) long term versus
      short term immunosuppression.

PMID- 1031687
TI  - The significance of positive controls in testing the oncogenic potential of cell
      material for virus vaccine production.
AB  - For all the parts involved in the production and control of virus vaccine it is
      important that controls of the cell material should be carried out under optimal
      conditions for the detection of any abnormal characteristics of the cells. The
      experiments reported here attempt to establish some of the optimal parameters for
      testing out the tumor-inducing properties of a human diploid cell culture. All
      experiments were carried out on 6-week old Syrian hamsters and the main
      objectives were: (i) to devise an optimal immunosupression scheme and (ii) to
      find a more suitable positive control for testing the oncogenic potential of the
      human diploid cells. The anti-hamster lymphocyte serum proved to be a more potent
      immunosuppresser than hydrocortisone succinate as seen from the development of
      tumors following injections with KB cells; this scheme was subsequently used in
      assessing the usefulness of KB and Swiss-12 cells as positive controls. The
      experiments lend support to the suggestion that a heteroploid fibroblastic
      culture (such as Swiss-12) should become a standard positive control since not
      only are the tumors so obtained larger and less prone to early necrosis but, more
      important, they bear a closer resemblance to the kind of tumors likely to be
      induced by the diploid cell cultures being tested.

PMID- 1031688
TI  - Production and control of rabies vaccines made on diploid cells.
AB  - Introductory remarks on the advantages of antirabies vaccines obtained from human
      diploid cell cultures in comparison with brain tissue vaccine and duck embryo
      vaccine. The characteristics of these new types of vaccine are: (i) high
      antigenicity, (ii) rapid development of antibodies, (iii) absence of adverse
      reactions even when the booster inoculation was given two years later. The
      disadvantage is the high cost of production to obtain a highly purified product.

PMID- 1031689
TI  - Post-exposure use of human diploid cell culture rabies vaccine.
AB  - 880 individuals, 120 of which were exposed to rabid animals, were immunized pre-
      or post-exposure with 2 different BPL-inactivated and concentrated rabies
      vaccines prepared in HDC strains WI-38 and MRC-5. The vaccines were well
      tolerated and no major side effects were observed after primary immunization with
      3-10 doses or 1 booster vaccination. The dynamics of neutralizing, antibody
      formation and persistence of antibodies in 4 different groups of vaccinees are
      described. The groups were vaccinated pre-exposure (I) on days 0, 28 and 56; (II)
      on days 0, 7 and 14; (III) on days 0, 3, 7 and 21; and (IV) post-exposure on days
      0, 3, 7, 14, 30 and 90. High antibody levels--persisting for at least 30 months-
      were obtained in all patients. The CFT, using a concentrated and purified virion
      antigen, was highly specific for rabies virus antibody demonstration. Since in
      some 50 patients under severe risk, after having been bitten and/or scratched by
      proven rabid animals, not a single breakthough of immunity was observed during an
      observation time between 1/2 and 3 years, the protective effect of the HDCS
      rabies vaccines seems to be excellent. With regard to their high immunogenicity
      and extremely low reactogenicity, the new HDCS-vaccines can be recommended for
      prophylactic and post-exposure immunization of man without any reserve. Data on
      simultaneous application of homologous anti-rabies gammaglobulin from man (20
      I.E./kg body-weight) and HDCS-vaccines are also presented and discussed.

PMID- 1031690
TI  - Clinical responses to T(n)BP-disrupted HDCS (WI-38) rabies vaccine.
AB  - Study of 10 batches of an antirabies vaccine made from purified, concentrated
      subunits (Pitman-Moore strain adapted to Wistar HDCS). One single dose of vaccine
      is insufficient; three or more doses induce high antibody levels. Among more than
      2000 vaccines secondary reactions were rare and generally mild and transient. All
      the individuals vaccinated post-exposure remained without rabic symptoms. The
      vaccine was also particularly efficacious for booster doses.

PMID- 1031691
TI  - Production of RA27/3 rubella vaccine and clinical results with the vaccine.
AB  - Adaptation of rubella virus to human diploid cell strains was achieved in 1964,
      with attenuation in the same cells being accomplished by 1967. The production of
      rubella vaccine in HDCS is featured by the long period required to build up high
      titer. High multiplicity of infection gives optimal results. Since rubella virus
      does not produce a cytopathic effect in HDCS, virus harvests must be made blindly
      and titrated individually before pooling. A unique feature of this cell-virus
      relationship is the continuous virus production which takes place for months. For
      vaccine purposes, however, virus-containing supernatant fluids may be harvested
      each 48 hrs from the 5th to the 21st day post-infection. Lyophilization presents
      no particular problems and final titers in ampoules can be as high as 10(5.0)
      PFU, which represents about 100 subcutaneous doses. Control of rubella vaccine
      presents only the problem that viral CPE is absent or mild. Therefore the
      presence or absence of virus may have to be determined by interference. Titration
      of rubella virus produced in HDCS must be by plaquing in RK13 rabbit kidney cells
      or by interference in cynomolgus monkey kidney cells. Rubella vaccine (RA27/3
      strain) produced in HDCS has been more immunogenic than other strains and retains
      an ability to infect intranasally as well as subcutaneously.

PMID- 1031692
TI  - Use of human diploid cell MRC-5, for production of measles and rubella virus
      vaccines.
AB  - A further attenuated strain of measles virus, called AIK strain, developed by
      Makino and his colleagues at the Kitasato Institute, Tokyo, was adapted to human
      diploid cells (HDC), MRC-5. In a field trial it was found that this strain
      initiates a low rate of clinical reactions and 100% seroconversion in vaccines.
      An attenuated strain of rubella virus, called Takahashi strain, isolated by
      Shishido at the National Institute of Health, Japan, was also adapted to HDC, MRC
      5. Brief details of production of an experimental rubella vaccine are given. Up
      to 20 harvests of virus were made from each culture without any apparent
      alteration of diploid cells.

PMID- 1031693
TI  - Mislabeling, contamination, and other sins of cultured flesh.

PMID- 1031694
TI  - Towards a chemically defined medium for the growth of normal human diploid cells.

PMID- 1031695
TI  - The nutrient requirements of MRC-5 human diploid cells.
AB  - Nutrients were assayed by their effect on maximum cell yield (maximum cell
      population less inoculum) of MRC-5 cells previously maintained in Eagle's basal
      medium with 10% (v/v) serum, trypsinised, centrifuged and washed. When
      nonlimiting amounts of iron, methylcellulose and a 68-component supplement were
      included in our defined medium, cell yields obtained were equivalent to those
      obtained with 2 to 3% whole serum. Growth then became limited by serum growth
      factors which, when serum was fractionated by the low temperature ethanol
      procedure, appeared to precipitate with the alpha-globulins, although the
      distribution of activity varied from batch to batch of serum. Column
      chromatography (DEAE and concanavalin A-Sepharose) of serum resulted in much (20
      to 45%) loss of growth factor activity during exhaustive dialysis or Sephadex G
      25 desalting suggesting that the growth factor may be a diffusible molecule bound
      in serum to a large protein carrier.

PMID- 1031696
TI  - [Septicemia in urology; the viewpoint of the bacteriologist].

PMID- 1031697
TI  - [Value of positive hemoculture in urology].

PMID- 1031698
TI  - [Etiopathogenesis of septicemia in urology].

PMID- 1031699
TI  - [Septicemia in urology. Study of 43 cases: the role of obstruction in the
      excretory tract].

PMID- 1031700
TI  - [Apropos of 27 cases of septicemia of urologic point of departure].

PMID- 1031701
TI  - [Acute microbial interstitial nephropathies during septicemia of urologic point
      of departure].

PMID- 1031702
TI  - [Apropos of a series of cases of septicemia in a urology department].

PMID- 1031703
TI  - [Septic complications in a case of diagnosed silent kidney].

PMID- 1031704
TI  - [Septic kidney (acute clinical aspect)].

PMID- 1031705
TI  - [Risks in plastic surgery of the kidney pelvis and the superior ureter].

PMID- 1031706
TI  - [Septicemia in urology].

PMID- 1031707
TI  - [Septicemia and septic shock].

PMID- 1031708
TI  - [Treatment of septicemia of the urologic origin].

PMID- 1031709
TI  - [Renal septicemia. Experiences with surgical treatment and antibiotic therapy].

PMID- 1031710
TI  - [Treatment of urologic septicemia].

PMID- 1031711
TI  - [Triple therapeutics in cases of septicemia].

PMID- 1031712
TI  - [Differential therapy of acute renal insufficiency following septicemia in
      urology].

PMID- 1031713
TI  - [Prevention of infections of the lower urinary tract].

PMID- 1031714
TI  - [Septicemia in urology. Conclusions of the recorder].

PMID- 1031715
TI  - [Pathology of the residual ureter].

PMID- 1031716
TI  - [Residual ureter after nephrectomy for urinary tuberculosis].

PMID- 1031717
TI  - [Residual ureter and its infections pathology (excluding tuberculosis)].

PMID- 1031718
TI  - [Ureteral stump after nephrectomy for papillomatosis].

PMID- 1031719
TI  - [Ureteral stump in pediatric urology].

PMID- 1031720
TI  - [Pathology of ureteral stumps (Trousseau statistics)].

PMID- 1031721
TI  - [Technics of nephro-ureterectomy and of exeresis of ureteral stumps].

PMID- 1031722
TI  - [Cinematographic examination of the mobility of the ureteral stump].

PMID- 1031723
TI  - [Incidence of the residual ureter pathology].

PMID- 1031724
TI  - [Pathology of the ureteral stump remaining after nephrectomy in for congenital
      malformation: an unusual contingency].

PMID- 1031725
TI  - [The forgotten ureteral stump].

PMID- 1031726
TI  - [Ureteral stump after 1,157 cases of nephrectomy for tuberculosis].

PMID- 1031727
TI  - [Pathology of the residual ureter].

PMID- 1031728
TI  - [Residual ureter after treatment for tumor of the pelvis or ureter].

PMID- 1031729
TI  - [How and in which cases can secondary ureteral tumors be prevented?].

PMID- 1031730
TI  - [Metastasis in the residual ureter after 7 years have passed since nephrectomy
      for adenocarcinoma].

PMID- 1031731
TI  - [An unusual case of papillomatosis of the residual ureter].

PMID- 1031732
TI  - [Urinary cytology: a diagnostic means in tumors of the ureteral stump].

PMID- 1031733
TI  - [Apropos of a case of pathology of the residual ureter in papillomatosis of the
      kidney pelvis].

PMID- 1031734
TI  - [Multiple lithiasis in residual megaureter after nephrectomy].

PMID- 1031735
TI  - [Apropos of 11 cases of the residual ureter. Endoscopic and surgical treatment].

PMID- 1031736
TI  - [Our surgical management of the residual ureter].

PMID- 1031738
TI  - [Definition of renal dysplasias].

PMID- 1031737
TI  - [Round Table. Cystic diseases of the kidney in children. Introduction].

PMID- 1031739
TI  - [Multicystic kidney].

PMID- 1031741
TI  - [Round Table. Cystic diseases of the kidney in children. II. Familial forms.
      Introduction].

PMID- 1031740
TI  - [Cystic dysplasia of the kidney associated with obstructive uropathy].

PMID- 1031743
TI  - [Juvenile polycystic diseases].

PMID- 1031742
TI  - [Polycystic kidney in childhood].

PMID- 1031744
TI  - [Renal cysts in hereditary or congenital syndromes].

PMID- 1031745
TI  - [Simple serous cyst of the kidney in children].

PMID- 1031747
TI  - [Medullary sponge kidney in childhood].

PMID- 1031746
TI  - [Multilocular cyst or cystadenoma?].

PMID- 1031748
TI  - [Hydatid cysts of the kidney in childhood].

PMID- 1031749
TI  - [Round Table. Cystic diseases of the kidney in children. IV. Recapitulation].

PMID- 1031750
TI  - [Multicystic renal dysplasia. Clinical study and results of microdissection in 6
      cases].

PMID- 1031751
TI  - [Association of renal and ureteral malformations: an embryogenic hypothesis].

PMID- 1031752
TI  - [Microcystic renal lesions in congenital intrahepatic biliary fibroadenomatosis].

PMID- 1031753
TI  - [Benign hemorrhagic cyst of the kidney in a 9-1/2-year-old boy].

PMID- 1031754
TI  - [Diagnosis of cystic diseases of the kidney in the last trimester of fetal life
      and in the neonatal period].

PMID- 1031755
TI  - [Microsurgery of segmental branches of the renal artery on the kidney ex situ.
      Experimental study].

PMID- 1031756
TI  - [Penetrating wounds of the kidney. Specific problem of the preservation of the
      renal parenchyma].

PMID- 1031757
TI  - [Surgical treatment of dysplastic lesions of the branches of the renal artery].

PMID- 1031758
TI  - [Leak-proof cystostomy].

PMID- 1031759
TI  - [Ureteral obstruction in uterine prolapse].

PMID- 1031760
TI  - [Association of renal and ureteral malformations: an embryogenic hypothesis].

PMID- 1031761
TI  - [Telethermography of external genital organs of the male].

PMID- 1031762
TI  - [Cecal bladder with a device assuring continence].

PMID- 1031763
TI  - [Computerized axial tomography, a new method of examining renal and
      retroperitoneal structures].

PMID- 1031764
TI  - [Use of computerized transverse axial tomography in urology. Preliminary note].

PMID- 1031765
TI  - [Iatrogenic stenosis of the urethra in boys. Apropos of 3 cases].

PMID- 1031766
TI  - [Contribution of osseous scintigraphy in the detection of metastases of cancer of
      the prostate].

PMID- 1031767
TI  - [Transperineal cryosurgery in the treatment of cancer of the prostate].

PMID- 1031768
TI  - [Artificial bladder].

PMID- 1031769
TI  - [Cavernous spermatocystitis].

PMID- 1031770
TI  - [Nephrogenic metaplasia of the bladder].

PMID- 1031771
TI  - [Apropos of 2 cases of pelvic lipomatosis].

PMID- 1031772
TI  - [Follow-up of more than 4 years on the same silastic tube in a case of
      transuretero-ureteronephrostomy].

PMID- 1031773
TI  - [Complications of the cutaneous stoma in transileal ureterostomy].

PMID- 1031774
TI  - [Experimental study on a vesical prosthesis made of silicone elastomers].

PMID- 1031775
TI  - [Prostatism in women: fibromyoma of the vagina].

PMID- 1031776
TI  - [Arteriography of internal pudendal arteries and revascularization of the corpus
      cavernosum in impotence of vascular etiology].

PMID- 1031777
TI  - [Leydig-cell tumor. Postoperative study of 9 cases during 7 years].

PMID- 1031778
TI  - [Late ureteral obstructions and aorto-femoral grafts].

PMID- 1031779
TI  - [Surgery of impotence].

PMID- 1031780
TI  - [Renal and vesical complications of a broncholytic agent. Experimental study in
      rats].

PMID- 1031781
TI  - [Sequential renal radioisotope study using the LHOV camera].

PMID- 1031782
TI  - [Vesical bipartition or Magder's operation].

PMID- 1031783
TI  - [Renal polycystic disease with dominant transmission in children].

PMID- 1031784
TI  - [Lipid and phospholipid content of canine liver tissue after portacaval
      anastomosis with or without additional arterialization of the intrahepatic portal
      vein].
AB  - The concentration of phospholipids and total lipids was determined 4 weeks after
      a portocaval shunt (PCS) in liver tissue of adult mongrel dogs. The concentration
      of total lipids increased from 33.5 +/- 3.6 to 71.2 +/- 6.9 mg/g ww, whereas the
      concentration of phospholipids declined from 26.1 +/- 3.1 to 19.8 +/- 7.8 mg/g
      ww. These changes are not observed when, in addition to the PCS, a pressure
      adapted arterialization of the liver is established. They are therfore caused by
      the decreased blood supply to the liver after PCS alone.

PMID- 1031785
TI  - [Etiology of benign papillary stenoses].
AB  - In domestic pigs repeated applications of gastrointestinal hormones
      (pancreozymin, secretin) as well as cholecystectomy lead to histologic
      transformation of the epithelium in the area of the papilla of Vater and to
      inconstant pressure changes in the common duct.

PMID- 1031786
TI  - [Myocardial blood flow and oxygen consumption in the fibrillating and empty
      beating heart].
AB  - Myocardial flow and oxygen consumption are reduced during cardiopulmonary bypass.
      In ventricular fibrillation both flow and O2 consumption are higher than in the
      empty beating heart; after the fibrillation flow remains elevated although O2
      consumption decreases. Aortic pressure is the major determinant of the myocardial
      flow rate, especially in hemodilution.

PMID- 1031787
TI  - [Studies on the local motility and blood circulation of the heart muscle during
      and after long-term coronary strangulation].
AB  - In ten young pigs a severe prolonged and critical stenosis of a major coronary
      artery was produced under control of an electromagnetic flowmeter. With stepwise
      constriction flow could be reduced to 55% of control with only minor hemodynamic
      changes. Local myocardial segment shortening was depressed to approximately 30%
      of control values. Hypokinesis was partially reversible within the first 135 min
      after reperfusion and had disappeared 24 h later. Computerized perfusion
      scintigraphy with radioactive microspheres gives a reliable approximation of the
      degree of myocardial blood flow reduction.

PMID- 1031788
TI  - [Myocardial blood flow and ventricular function in dependence on the size of
      myocardial infarct].
AB  - In eight dogs three branches of the left anterior descending coronary artery were
      occluded by successive ligations. Each time coronary flow reserve was measured by
      injecting dipyridamole (0.4 mg.kg-1). After an infarction of 13% of the left
      ventricle there was a significant decrease of Vmax and dp/dtmax (p less than
      0.05). Measurements of regional myocardial blood flow detected an infarction of
      5% of the left ventricle, whereas the total myocardial blood flow was reduced
      significantly when 17% of the left ventricle was infarcted.

PMID- 1031789
TI  - [Animal experiments with a new intracardial pacemaker electrode].
AB  - In order to reduce the rate of dislocation of intracardiac pacemaker electrodes,
      a new electrode was developed. The tip of this new electrode is helical and can
      be fixed between the trabecles of the right ventricle by clockwise rotation.
      Since the tip of this new electrode has no sharp hooks the myocard cannot be
      damaged by fixation.

PMID- 1031790
TI  - [Frequency-optimal pacing in chronic pacemaker therapy].
AB  - Hemodynamic studies were performed in 15 pacemaker patients at rest and during
      exercise by thermodilution technique and impedance cardiography. Particularly in
      myocardial failure, individual optimal heart rates were observed, ranging from 90
      to 120/min. Mean increase of cardiac output at optimal pacing rate was 1.31/min
      against stimulation at 70/min. Impedance cardiography showed high correlation to
      thermodilution technique.

PMID- 1031791
TI  - [Criteria for the choice of a membrane oxygenator in long-term oxygenation].
AB  - Five different membrane oxygenator devices were tested in dogs. The following
      criteria were compared: operating reliability, gas exchange rates, and changes of
      the mean erythrocyte volume.

PMID- 1031792
TI  - [Study of turbulence in the normal and stenotic vessel].
AB  - Velocity measurements were performed at the test bench, in dogs and in patients
      with pulsed ultrasound. A new zero crossing counter was used to measure the
      different frequencies of the doppler spectrum in real time. The ratio of the
      standard deviation of the radial mean velocity to the radial mean velocity
      expressed as a percentage proved to be a useful turbulence index to describe
      stability of flow.

PMID- 1031793
TI  - [Significance of various implantate localizations of Sparks prostheses,
      experimental studies in rats].
AB  - Our investigations show that Sparks prostheses after subcutaneous implantation
      are suitable for vascular grafting. At the end of the organization period the
      connective tissue becomes strong, and after the third and fourth weeks
      collagenous and elastic fibers can be seen. Ten weeks after s.c. implantation,
      collagenous fibers predominate. After this the Sparks prostheses can be used as a
      vascular graft. Intraperitoneal implantation, however, shows a histologically
      different picture with characteristic findings: only fat cells can be observed, a
      strong granulation tissue with elastic and collagenous fibers is not present.
      After intraperitoneal implantation Sparks prostheses are therefore unsuitable for
      vascular grafts.

PMID- 1031794
TI  - [Morphological and functional changes in the closing sphincter of the lower
      esophagus after experimentally-induced hiatal hernia].
AB  - Report of an experimental model of axial hiatal hernia in dogs, always combined
      with reflux (roentgenologic control). Using a new method of pressure measurement,
      the authors succeeded in proving the distention of the esophageal "sphincter".
      Morphologic investigations demonstrated, that in hernia the muscle fiber is no
      longer an apolar helical fiber, but runs nearly horizontally. The reduced
      susceptibility to pentagastrin is caused by diminished tension of the muscle
      fiber. The distal esophageal closing mechanism consequently seems to be a
      function of the whole organ and not of a hormonally regulated sphincter.

PMID- 1031795
TI  - [Influence of somatostatin (GIF) and human gastrin I on the lower esophageal
      sphincter].
AB  - The influence of gastrin and somatostatin on the lower esophageal sphincter was
      investigated in 10 metabolically healthy volunteers and one patient with
      Zollinger-Ellison syndrome. It could be shown that only unphysiologically high
      concentrations of gastrin produced a rise in pressure in the lower esophageal
      sphincter, while somatostatin has neither an effect on the lower esophageal
      sphincter pressure, nor is it able to inhibit the pharmacologic effect of
      exogeneous gastrin administration. The results emphasize that gastrin and
      somatostatin have no influence on the tone of the lower esophageal sphincter.

PMID- 1031796
TI  - [Manometric studies on the influence of selective proximal vagotomy on the lower
      esophageal sphincter].
AB  - Selective proximal vagotomy (SPV) decreases the LES pressure (resting pressure
      and pentagastrin-stimulated pressure), significantly 6 months postoperatively
      without achieving LES insufficiency by clinical means. Immediately after
      stimulation LES pressure is identical, compared to preoperative measurements.
      Concentration of serum gastrin is not a major determinant of LES tone in humans.

PMID- 1031797
TI  - [Myoelectrical changes of activity of the Vater's ampulla after various forms of
      vagotomy in the dog].
AB  - The effects of varying the extent of vagotomy on the myoelectrical activity of
      the sphincter of Oddi have been successfully studied in 12 dogs undergoing either
      truncal, selective, or highly selective vagotomy. Both the amplitude and the
      shape of the single action potentials as well as the interval change in the
      electrical activity in the sphincter of Oddi in relation to the extent of the
      vagal denervation. No significant change of frequency and amplitude of the
      myoelectrical activity occurred after highly selective vagotomy which proves to
      be the best method.

PMID- 1031798
TI  - [Reproducibility and specificity of insulin-injection and insulin-infusion tests
      in the examination of complete vagotomy].
AB  - The reproducibility of insulin injection tests, the comparison of insulin
      injection and insulin infusion tests and the specificity of the insulin injection
      tests were investigated in 74 duodenal ulcer patients. New failures of the
      insulin test were detected. The criterion of BACHRACH produced more positive
      "insulin tests" after injection of sodium chloride than after insulin itself.
      Therefore it is recommended that in single cases (recurrent ulcer) insulin
      injection tests (HOLLANDER criterion) should be repeated and that a sodium
      chloride test should be performed.

PMID- 1031799
TI  - Effects of vagotomy on the catecholamine-containing cells in the gastric mucosa
      of the rat: an electron microscopic study.
AB  - The ECL cells in the fundic mucosa from five different groups of fasted rats were
      examined by means of electron microscopy; in the control animals, the majority of
      the secretory granule of the ECL cells contained electron-dense material.
      Previous studies in our laboratory indicate that this material probably
      represents a catecholamine. In the second and third groups, in which truncal
      vagotomy plus pyloroplasty was performed, the secretory granules were depleted of
      their content. In the fourth group in which vagotomized animals were treated with
      iproniazid and L-dopa, the mature secretory granules were depleted but formation
      of new granules was apparent. In the fifth group, in which pyloroplasty alone had
      been performed, the content of the granules was the same as in the control group.
      It was concluded that the endocrine function of the ECL cells is under vagal
      control and that vagotomy causes release of catecholamines from these cells.

PMID- 1031800
TI  - [Experimental studies of the effects of gastrin, neostigmine and prostaglandin on
      the motility of the trunculary vagotomized stomach].
AB  - The working effect of Gastrin, neostigmine and prostaglandin in regard to the
      emptying of the stomach was tested on 31 dogs that had undergone a truncular
      vagotomy. Gastrin and neostigmine were proved to increase the motility at the
      stomach pylorus but was not able to bring about a coordinated emptying pattern.
      Prostaglandin shows different effects on the emptying reflex of the stomach. PGF
      2 alpha increases the motility on the measuring marks, but at different time
      intervals. Because of this a coordinated motility is made possible.

PMID- 1031801
TI  - [Studies on the hormonal regulation of the esophago-gastric and gastro-duodenal
      high-pressure zone after vagotomy and resection of the antrum].
AB  - Studies on gastric emptying after antrectomy and vagotomy with gastroduodenostomy
      show that the gastric remnant empties in the same way as the intact stomach by
      hormonal control. If gastrointestinal passage after gastric resection is restored
      by gastrojejunostomy no endocrine regulation can be found.

PMID- 1031802
TI  - [Mono- or biphasic release of gastrin. Results after isolated antrum perfusion in
      vitro].
AB  - In an in vivo preparation, isolated rat antra were perfused with different
      releasing agents in an oxygenated Krebs-Ringer-A solution. Upon perfusion with
      acetylcholine (+ 0,1 mM eserine), the mean gastrin levels in the effluent
      increased within 2 min to 4 times the basal level, while there was a smaller
      second release after 20 min. During perfusion with 50 mM glycine and 30 mM
      calcium chloride containing Krebs-Ringer-A solution gastrin levels in the
      effluent increased within 4 min to twice the basal level without a secondary
      release of gastrin. Perfusion with eserine alone or with Krebs-Ringer-A solution
      failed to release gastrin. The apparent biphasic release of gastrin with
      acetylcholine may suggest that antral gastrin may exist in two different
      populations, one of which is readily accessible, the other less so.
      Alternatively, the initial peak may consist only of stored gastrin and the second
      peak of newly synthesized gastrin, stimulated only by the physiologic stimulus of
      acetylcholine, and not by other releasers.

PMID- 1031803
TI  - [Studies of the relationship of gastric motility, gastrin secretion and HCl
      biosynthesis in patients with duodenal ulcer].
AB  - Serum gastrin, acid output and gastric emptying were measured in patients with
      duodenal ulcer. 1. Eighty-two patients with duodenal ulcer evacuate a semisolid
      meal with differing patterns: rapid (n = 24), normal (n = 46), and delayed (n =
      12). 2. Comparing patients with rapid and delayed gastric emptying, basal and
      peak serum gastrin and integrated gastrin output are significantly higher in the
      rapid emptying group.

PMID- 1031804
TI  - [Importance of bile for stress ulcer in the rat].
AB  - The influence of bile on ulcer formation under restraint stress condition was
      studied in rats. Animals with a choledochogastrostomy or a pyloroplasty showed as
      many ulcers as the sham-operated controls. After choledochoileostomy or bile duct
      ligation the ulcer frequency was reduced by half. A pharmacologic binding of the
      bile salts by intragastral cholestyramine had the same effect.

PMID- 1031805
TI  - [Lose-dose treatment with vitamin A in prevention of stress ulcer in swine].
AB  - Hemorrhagic shock in 8 piglets (mean AoBP 40 mm Hg for 3 h) was followed by
      severe stress-induced gastric mucosal lesions (Gr-I). When vitamin A was
      administered simultaneously (50,000 IE/kg = Gr. II, n = 6 and 5,000 IE/kg = Gr.
      III, n = 7) during the procedure, no stress lesions were observed. The study
      shows that the simultaneous application of vitamin A during hemorrhagic shock, in
      a reasonable clinical dosage, protects the gastric mucosa against stress-induced
      lesions.

PMID- 1031806
TI  - [Calcium in the prevention of stress ulcer in the rat].
AB  - Calcium gluconate, carbonate, and lactate are potent antiulcerogenic agents when
      administered intragastrically at pH 6.3 by sustained infusion (45 mg/kg/8 h). In
      intact rats, by radioimmunologically measurable serum, gastrin and calcitonin are
      inversely correlated, whereas gastrin and ulcer index tend to correlate directly.
      The findings imply a key role for thyroid-releasable endogenous calcitonin in
      this disorder.

PMID- 1031807
TI  - [Experimental studies on the small-intestine invagination valve in continent
      ileal bladder].
AB  - A method for constructing a continent ileal bladder was tested in dogs. The
      requirements for a continent ileal bladder: i.e., continency, reservoir function,
      and prevention of reflux, could be fulfilled in our experimental study.

PMID- 1031808
TI  - [Total colectomy with proctomucosectomy and ileal passage--animal experiment
      studies].
AB  - Resection of the rectal mucosa, total colectomy and continent anal ileostomy was
      carried out on 10 dogs. Nine dogs survived. One dog died of small bowel volvulus.
      A complete morphologic integration of the ileum loop within the rectal muscle
      tube could be demonstrated angiographically and histologically. Continence was
      retained.

PMID- 1031809
TI  - [Relationship of the healing process in large intestine anastomosis to the size
      of vascular skeletization].
AB  - Healing process of single- and double-layer sutures were demonstrated in rats
      after different degrees of mobilization. Clinical, angiographic, and histologic
      comparison demonstrates a prolonged healing process after more than 1-cm
      mobilization. Double-layer sutures showed a high rate of insufficiency.

PMID- 1031810
TI  - [Humoral and cellular immunologic reaction after allogeneic transplantation of
      veins in rats--experimentally studied on immunogenetically defined recipient
      donor-combinations].
AB  - Vital venous transplants lead to sensitization and induce an immunologic
      reaction. In the weak allogeneic system only the cell-bound immune reactivity can
      be identified, whereas in the strong allogeneic system both humoral and cell
      bound reactivity can be quantitatively determined.

PMID- 1031811
TI  - [Resorption of fats and carbohydrates following stomach resection and
      gastrectomy].
AB  - 125I- and 14C-labelled triolein were used for the examination of fat absorption
      in patients after gastric surgery. Fat absorption decreased significantly after
      total and subtotal proximal gastrectomy, but less after distal gastric resection.
      Carbohydrate absorption, as measured by D-Xylose test, increased in the same
      manner after both total and partial gastrectomy.

PMID- 1031812
TI  - [Therapeutic modification of blood circulation disorders of the intestine due to
      strophantin].
AB  - The vasoconstrictor effects of strophanthin on mesenteric hemodynamics were
      studied using mechanical ventricular massage to exclude the cardiac effects of
      the drug. The administration of a calcium antagonistic compound prior to
      digitalis, together with and after digitalis application, prevented the
      vasoconstrictor response completely. From our experimental experience the
      combination of cardiac glycosides with calcium antagonistic compounds seems
      rational.

PMID- 1031813
TI  - [Antibiotica release from bone cement in animal experiment].
AB  - The release of antibiotics from bone cement palacos into cortical bone after
      experimental ostemyelitis in sheep was demonstrated by our experiments. High
      carbenicillin and cephalothin concentration levels were present for 2 weeks, but
      after 3 weeks were no longer evident. Lincomycin and gentamicin in the first days
      showed high tissue levels, then decreased and increased again after the 2nd week.
      Gentamicin was examined over 10 months, producing high levels after this time
      also.

PMID- 1031814
TI  - [Behavior of reactive shaft pseudarthroses of the canine radius in the electric
      and electromagnetic fields].
AB  - In 27 beagles, 19 radius shaft pseudarthroses and 8 tibia were stimulated either
      by directly applied alternating current of low frequency and strength, delivered
      from an implanted battery source, or by a pulsing electromagnetic field
      inductively coupled to bone. Increase of periosteal callus was only found beneath
      parallel sling electrodes placed on pseudarthroses parallel to the radius shaft.
      Stimulation by transverse electrodes implanted into bone produced no significant
      increase of osteogenesis and bone healing, evaluated by x-rays, scintigrams, and
      morphometry when compared with contralateral leg controls.

PMID- 1031815
TI  - [Modification of the pseudarthrosis healing process by alternating magnetic
      fields in vivo].
AB  - The effect of the magnetic field according to the Kraus-Lechner model was
      investigated on experimental pseudarthroses in beagle dogs. Double-blind
      evaluation of the 12 experimental pseudarthroses demonstrated that the magnetic
      field, applied for 3 months, had no effect on healing.

PMID- 1031816
TI  - [Influence of magnetic fields on growth and regeneration in organ culture].
AB  - The influence of alternating magnetic fields (30 Gauss, 20 Hz) on the growth and
      regeneration of embryonic rat femora in organ culture was investigated. A pure
      magnetic field was ineffective at a constant temperature.

PMID- 1031817
TI  - [Allogeneic small intestine transplantation in inbred rats. Transplantation
      technic and morphological findings].
AB  - In a RtH-1-incompatible in-bred rat strain combination (Brown Norway leads to
      LEWIS), small intestinal transplantations were carried out using the bypass
      technique. 5, 10 and 12 days after grafting, the transplanted intestines were
      histologically examined. On the 5th day primarily granulocyte cell infiltration
      was found. On day 10 and 12 there was an increase of lymphocyte plasma cellular
      infiltration. The small intestine showed increasing congestion of the lymphatic
      vessels, an edematous saturation of the stroma as well as loss of the small
      intestinal-specific epithelial layer.

PMID- 1031818
TI  - [Long-term results after cartilage transplantation].
AB  - The authors' experimental work is concerned with the structure of articular
      cartilage after transplantation. In the medial condylus of the femur of the
      rabbit, bone-cartilage defects were produced and filled with bone-cartilage
      autografts and homografts preserved by different methods. At 2, 4, 6, 12, and 24
      months after operation animals were sacrificed. The first phase of the healing
      process shows regressive processes. The second phase is marked by reactions of
      repair. The results of the experiment indicate that transplantation of cartilage
      can be regarded as a possibility of therapy in order to heal bone-cartilage
      lesions.

PMID- 1031819
TI  - [Animals experiment studies on the microstructural behavior of hyaline articular
      cartilage after immobilization and remobilization].
AB  - Early degenerative changes of the articular cartilage in knee joints of rabbits
      were observed after immobilization and weight bearing. These changes were not
      reversible. After remobilization there was an increase in the alterations. The
      clinical significance of these findings is discussed.

PMID- 1031820
TI  - [Revascularization of hypertrophic pseudoarthroses after pressure-plate
      osteosynthesis].
AB  - In 6 adult mongrel dogs hypertrophic pseudarthroses in the radius were produced.
      The pseudarthroses were stabilized by compression plate osteosynthesis. The
      changes in the pattern of vascularization in pseudarthroses under stabilization
      were studied by means of microangiography. The interfragmental gap
      revascularization started early and came from medullary vessels of both
      fragments. Vessel anastomoses in interfragmental areas were observed. With time,
      medullary and periosteal hypervascularization were reduced. However, the
      hypervascularization in the remodeled corticalis was still evident after 3
      months.

PMID- 1031821
TI  - [Revascularization of devitalized cortical segments under stabilizing encircling
      wires].
AB  - In 10 adult mongrel dogs isolated cortical fragments of the diaphysis of the
      radius were reimplanted and stabilized by encircling wires. The changes in the
      pattern of vascularization and the revitalization of the avascular fragment were
      investigated by microangiography. The revascularization arose from the medullary
      vessels that penetrated the avascular fragment. The fracture gap was bridged by
      intracortical anastomoses. After 6 weeks fracture healing was noted and the
      vessels showed a restoration of the physiologic pattern of vascularization.

PMID- 1031822
TI  - [Preservation of dog limbs through hypothermic perfusion].
AB  - Different methods of preservation are examined in long-lasting extremity ischemia
      in dogs. After preservation of 10 h duration by hypothermia and perfusion the
      status of energy-rich phosphates and pH was equivalent to the status after 2 h of
      ischemia under control conditions.

PMID- 1031823
TI  - [Pulmonary lipoprotein lipase activity after experimental bone fracture].
AB  - Five hours after a limited, nonhypotensive trauma without gross interference with
      coagulopathy the lung of dogs was found to be completely deficient of heparin
      releasable, metabolically active lipoprotein lipase.

PMID- 1031824
TI  - [Preventive treatment with methylprednisolone and heparin in experimental trauma
      and hemorrhagic shock].
AB  - Twenty-six anesthesized mongrel dogs were subjected to a standardized traumatic
      hemorrhagic shock. Compared with the control group prophylactic treatment with
      high doses of methylprednisolone reduced functional and histologic alterations of
      the lung. Methylprednisolone in combination with heparin pretreatment prevents
      microthrombi but produces more alveolar bleeding.

PMID- 1031825
TI  - [Pulmonary hemodynamics, coagulation and morphological changes in the lung after
      thrombocyte aggregation inhibition and intravasal coagulation in experimental
      trauma and hemorrhagic shock].
AB  - 26 mongrel dogs are subjected to a standardized bone trauma followed by a
      hypotonic hemorrhagic shock. Compared with a control and heparin group
      prophylactic treatment with Dipyridamol and Acetylsalicylic Acid decreases
      pulmonary vascular resistance significantly. After an initial period of
      hyperocagulability secondary fibrinolysis develops. The decrease of the
      fibrinogen level and the fall of total platelet count after trauma and hemorrhage
      can partly be prevented by the application of heparin, likewise the development
      of pulmonary microthrombosis. Histological examination shows a markedly
      diminished pulmonary microthrombosis.

PMID- 1031826
TI  - [Prolonged survival of xenogeneic grafts after organ culture].
AB  - Organ culture of xenogeneic thyroids leads to a prolonged survival time. This
      effect can be reversed when donor-specific cells are injected at the time of
      transplantation. The results of this experiment disprove the assumption that
      target antigens are modulated or masked by organ culture.

PMID- 1031827
TI  - [Behavior of intestinal motility and serum gastrin level after administration of
      prostaglandin A1, E1 and F2alpha in recent mechanical ileus of the rabbit].
AB  - In a mechanical ileus model in 70 rabbits, the effects of PGF2alpha-infusions,
      PGE1- and PGA1-injections on jejunal pressure and serum gastrin levels were
      studied. PGF2alpha increases, whereas PGE1 inhibits jejunal motility. PGA1
      produces no significant response. A modulation of neurotransmission is discussed.
      The serum gastrin levels can be decreased by PGE1-injections, whereas PGA1
      effects only small decreases. The importance of the vagal mechanism for the
      release of gastrin is emphasized.

PMID- 1031828
TI  - [Effects of intraluminal pressure increase on oxygen consumption of the rabbit
      ileum and its possible pharmacological modification].
AB  - Elevated intraluminal pressure of rabbit small bowel induces a decrease of tissue
      pO2 of the bowel wall dependent on the applied pressure. After decompression
      local pO2 exceeds the initial pO2 values. While the i.v. application of 25
      microgram/kg glucagon is not able to improve local oxygen supply of the distended
      bowel, local pO2 increases considerably after infusion of 7.5 ml/kg dextran 40.
      Decompression by operation or intestinal tube as well as application of dextran
      40 are recommended in the treatment of ileus.

PMID- 1031829
TI  - [Resuscitation with stroma-free hemoglobin solution after acute blood loss].
AB  - Resuscitation and volume replacement after acute blood loss is possible for a
      short duration by means of 6% stroma-free hemoglobin solution (SFH). Despite
      transcapillary loss of SFH, pulmonary edema is not provoked after massive
      infusion of cristalloid solution. The oxygen supply to the tissues is maintained
      by a compensatory rise in cardiac output and O2-extraction, mainly from the
      remaining red cell hemoglobin.

PMID- 1031830
TI  - [Blood coagulation disorder, hemolysis and hypoalbuminemia after autotransfusion
      in experimental intraperitoneal hemorrhages].
AB  - Autotransfusion in a canine model (n = 15) causes anemia, thrombocytopenia,
      hypofibrinogenemia, hypalbuminemia, and metabolic acidosis and enhances
      elimination of intravenously injected 131I albumin. Contact of the shed blood
      with the peritoneal surface aggravates the pathologic findings; without
      simultaneous intraperitoneal heparinization the highest rates of hemolysis with
      concomitant oliguria were observed.

PMID- 1031831
TI  - [Behavior of IgG, IgA and IgM in aseptic and septic postoperative processes].
AB  - After sterile surgical procedures, serum IgG, IgA and IgM concentrations again
      reach normal values at the 10th postop. day after initial lowering. During
      septicaemia this decrease is significantly more pronounced. By i.v. application
      of a high dose of human gammaglobulin normal values can be reestablished.

PMID- 1031832
TI  - [Control of intensive care through the measurement of microcirculation and 02
      consumption].
AB  - The pO2-multiwire electrode measures the intercapillary oxygen tension. The pO2
      histogram, which results from such measurements gives precise information about
      the question as to whether microcirculation is disturbed or not. Thus,
      pathological changes in respiration and volume can be recognized earlier than
      with classical methods. The latter registers the mainly central variables which
      are compensated for a longer period of time. The local pO2 measurement allows
      individual regulation of respiratory therapy and monitors the response of oxygen
      therapy. Using this method oxygen deficiency as well as overdosage of oxygen
      supply can be averted. Thus, important diagnostic and therapeutic indications can
      be identified.

PMID- 1031833
TI  - [25-OH-vitamin D in the serum of patients with femoral-neck fractures].
AB  - In 10 women with femoral neck fracture, 10 with fracture(s) evolved from
      accidents (mainly traffic accidents) and 10 without disease (controls) in January
      and July, the 25-OH-vitamin D levels in serum were measured by a competitive
      protein binding assay. Patients with femoral neck fractures exhibited
      significantly (p less than 0.05) lower 25-OH-vitamin D levels than the other
      groups. Additionally, in patients with femoral neck fractures calcium x phosphate
      product in serum was subnormal (below 25). In Germany, prophylactic dietary
      supplementation of vitamin D seems feasible.

PMID- 1031834
TI  - [Criteria for the surgical treatment of hypothalamo-hypophyseal-dependent
      Cushing's syndrome].
AB  - This article offers criteria for the surgical treatment of pituitary-dependent
      Cushing's syndrome. Patients (n = 6) who showed no secondary complications of
      Cushing's disease underwent an implantation of 90Y and/or 192Ir into the
      pituitary gland. After implantation the excessive secretion of ACTH was
      suppressed to normal values and the symptoms of Cushing's syndrome disappeared.
      Following operation several patients received substitute therapy with other
      pituitary hormones. Fertility was not always conserved. Total adrenalectomy as
      alternative therapy was performed in adults with threatening symptoms of the
      disease (n = 4) and in children (n = 4). The symptoms of Cushing's syndrome
      disappeared. In two cases the development of a Nelson's tumor was observed. One
      was treated by implantation of 192Ir into the pituitary gland; the second needs
      no therapy up to now.

PMID- 1031835
TI  - [Treatment of capillary hemangiomas and nevi flammei with light].
AB  - A report on the treatment of capillary hemangiomas and nevi flammei using laser
      or broad-band infrared light to initiate thermal coagulation in the blood-filled
      vascular spaces, leaving intact the nonaffected overlying skin layers. Clinical
      experiences with 26 patients treated with equipment developed by the group are
      discussed.

PMID- 1031836
TI  - [Treatment of hepatic coma using extracorporeal perfusion with baboon and human
      liver as well as with activated charcoal].
AB  - In the 6 patients with hepatic coma hemoperfusions with 8 baboon and 2 human
      livers were carried out. Four awoke from the coma, one women could be discharged,
      but the others died of various complications and liver insufficiency. In the 4
      patients with hepatic coma, 11 hemoperfusions with activated charcoal columns
      were performed. Two awoke from the coma, but they died of liver insufficiency. We
      were able to detect the elevation of preforming antibodies in a discharged
      patient.

PMID- 1031837
TI  - Micro-organisms in the midgut of tsetse fly larvae.
AB  - Two types of micro-organisms were found in the midgut of Glossina morsitans
      larvae, a large Gram-negative bacterial rod and a small Gram-negative rickettsia
      like micro-organism, although the occurrence of the rickettsial type is
      restricted. The location of these micro-organisms in a small area of the
      proventriculus of all three larval instars is discussed. The large micro
      organisms resemble milk-gland bacteria, and further evidence is presented in
      support of a milk transmission hypothesis for these micro-organisms.

PMID- 1031838
TI  - Studies on the bacteriophage PS8 of Agrobacterium tumefaciens (Smith and
      Townsend) Conn: physico-chemical properties of its DNA.
AB  - DNA from the bacteriophage PS8 was extracted and purified. The buoyant density
      was determined was 1.716 cm3/g. The guanine-cytosine content was calculated to be
      57%. DNA molecules which looked like circles were found among linear strands in
      an electron-microscopic study. With an endonuclease from Streptomyces albus G the
      DNA was digested to 19 fragments, with molecular weights ranging from 600 to
      7,400 daltons. The molecular weight of the DNA was determined to be 38.8 X 10(6)
      daltons +/- 8.7%.

PMID- 1031839
TI  - Radiological diagnosis of posterior fossa tumours in childhood.

PMID- 1031840
TI  - The arteries of the posterior cranial fossa in new-born.

PMID- 1031841
TI  - Magnification angiography of the posterior cranial fossa in pediatry.

PMID- 1031842
TI  - The vascular malformations of the vertebrobasilar trunk in infancy.

PMID- 1031843
TI  - Various developmental anomalies of the posterior fossa. A radio-pathological
      study.

PMID- 1031844
TI  - Problems of diagnosis and treatment in the Dandy-Walker syndrome.

PMID- 1031845
TI  - Congenital atresia of the foramen of Magendie, so-called Dandy-Walker syndrome.

PMID- 1031846
TI  - Malformative pathology of the medial structures of the posterior fossa:
      considerations on 17 cases.

PMID- 1031847
TI  - Surgical management of Chiari malformation in children.

PMID- 1031848
TI  - Surgical treatment of encephalocele complicated by hydrocephalus.

PMID- 1031849
TI  - Late death in cases of treated internal hydrocephalus caused by encephalo-cranial
      disproportion.

PMID- 1031850
TI  - Cystic malformation of the aqueduct and of the fourth ventricle.

PMID- 1031851
TI  - Hypoplasia of the tentorium with pseudohernia of the occipital lobe into the
      posterior cranial fossa.

PMID- 1031852
TI  - Malformation of the cranio-vertebral region. Technical notes and case report.

PMID- 1031853
TI  - The treatment of posterior fossa tumours in childhood.

PMID- 1031854
TI  - CT (computerized tomography) in paediatric neurosurgery. Results of a survey of
      400 patients.

PMID- 1031855
TI  - Echographic and biochemical methods for evaluating hydrocephalus and shunting
      procedures.

PMID- 1031856
TI  - Cerebrospinal fluid absorption studies in patients with myelomeningocele and
      hydrocephalus. Preliminary report.

PMID- 1031857
TI  - The medical treatment of hydrocephalus using isosorbide.

PMID- 1031858
TI  - A new technical method of ventriculoatrial shunt implantation.

PMID- 1031859
TI  - Gas study in arrested hydrocephalus with chiasmatic block.

PMID- 1031860
TI  - Reconstitution of the cerebral mantle in shunted hydrocephalic children.

PMID- 1031861
TI  - Follow-up study of 360 children subjected to extracranial CSF shunt for
      hydrocephalus.

PMID- 1031862
TI  - The possible causes of good long-term results following surgical treatment of
      hydrocephalus.

PMID- 1031863
TI  - Membranoproliferative glomerulonephritis associated with infected
      ventriculoatrial shunt. Report of two cases recovered after removal of the shunt.

PMID- 1031864
TI  - Results of microsurgical treatment of gliomas of the optic system and the
      hypothalamus in children.

PMID- 1031865
TI  - Management and prognosis of gliomas of the optic pathways in children.
AB  - A follow-up study was made of 24 children with glioma of the optic pathways. In
      gliomas restricted to one optic nerve, total excision should be performed. The
      prognosis is excellent. Radiotherapy is not indicated. In gliomas of the anterior
      chiasm, a biopsy should be taken; occasionally, partial removal is indicated. The
      prognosis is good. Radiotherapy is indicated only if the follow-up shows a
      progression in the visual signs. In most cases, the growth of the tumor seems to
      be arrested. The vision remains stable and most patients have a useful degree of
      vision in at least one eye. In gliomas of the posterior chiasm with hypothalamic
      signs, the prognosis is poor. A biopsy and radiotherapy are indicated.

PMID- 1031866
TI  - Pituitary adenomas in infancy and childhood.

PMID- 1031867
TI  - Unusual features of an orbital neurofibroma.

PMID- 1031868
TI  - Operative indications in dysraphic malformations. Follow-up studies and late
      results.

PMID- 1031869
TI  - The present diagnostic approach of the mass lesions of the posterior fossa in
      children.

PMID- 1031870
TI  - Primary spinal cord tumors in infancy and childhood. Remarks on 53 operated
      cases.

PMID- 1031871
TI  - Neuroradiological and longitudinal studies of the pineal region tumors.

PMID- 1031872
TI  - A method in surgical treatment of premature closure of metopic suture
      (trigonocephaly).

PMID- 1031873
TI  - Operative problems in encephalocele.

PMID- 1031874
TI  - Pathogenetic hypothesis of intracortical calcifications in Sturge-Weber disease.
      Case report following lobectomy.

PMID- 1031875
TI  - Section of the portio minor of the trigeminal nerve for the treatment of the
      Marcus Gunn phenomenon.

PMID- 1031876
TI  - Brain abscess in children.

PMID- 1031877
TI  - Brain tumor with ipsilateral cerebral hemiatrophy in children.

PMID- 1031878
TI  - Kleeblattschadel syndrome. Report of a treated case.

PMID- 1031879
TI  - Hydatid cyst of the fourth ventricle in a six-year-old child.

PMID- 1031880
TI  - Severe head injury without mass lesion in children. The role of intracranial
      hypertension.

PMID- 1031881
TI  - Features of the clinical evolution following the acute stage in severe traumatic
      coma in childhood. A study of 45 cases of so-called apallic syndrome.

PMID- 1031882
TI  - Morbid anatomy of the tumours of the posterior fossa in childhood.

PMID- 1031883
TI  - Ventricular fluid pressure in posterior fossa tumors of childhood.

PMID- 1031884
TI  - Management of hydrocephalus secondary to posterior fossa tumors.

PMID- 1031885
TI  - Cerebrospinal fluid derivation in posterior cranial fossa tumor with
      hydrocephalus.

PMID- 1031886
TI  - The value of preoperative shunts in posterior fossa tumors.

PMID- 1031887
TI  - Clinical and diagnostic problems in posterior fossa tumors in children (analysis
      of 100 cases).

PMID- 1031888
TI  - Posterior fossa tumors in childhood.

PMID- 1031889
TI  - Tumoral versus non-tumoral posterior fossa lesions. A clinical diagnostic
      problem.

PMID- 1031890
TI  - Treatment and prevention of complications following surgery for tumors involving
      the posterior cranial fossa.

PMID- 1031891
TI  - Postoperative hyperthermia following posterior fossa craniotomy.

PMID- 1031892
TI  - New problems in the therapy of medulloblastomas.

PMID- 1031893
TI  - Experiences with radiotherapy and chemotherapy in the treatment of tumors
      involving the caudal brain stem.

PMID- 1031894
TI  - Posterior fossa tuberculomas.

PMID- 1031895
TI  - Acoustic neurinomas in infancy. Report on four cases.

PMID- 1031896
TI  - Diagnosis of posterior fossa malformations in infants and children using axial
      computerized tomography (CT).

PMID- 1031897
TI  - The value of computerized axial tomography (CAT) in early diagnosis of
      intracerebellar hemorrhage in children.

PMID- 1031898
TI  - Mucous glycoproteins.

PMID- 1031899
TI  - The composition of human gastric mucin.

PMID- 1031900
TI  - Synthesis and secretion of respiratory tract mucins by tracheal explants.

PMID- 1031901
TI  - Pathophysiology of mucus secretion in cystic fibrosis.

PMID- 1031902
TI  - Bronchial mucus secretion in cystic fibrosis.

PMID- 1031903
TI  - Tracheobronchial mucus secretion in vivo and in vitro by epithelial tissues from
      cystic fibrosis and control subjects.

PMID- 1031904
TI  - Mucins from cystic fibrosis sputum.

PMID- 1031905
TI  - Mucus rheology and mucociliary clearance.

PMID- 1031906
TI  - The effect of mucus cross-linking on the clearance of mucus.

PMID- 1031907
TI  - Impairment of mucociliary transport in cystic fibrosis.

PMID- 1031908
TI  - Mucociliary clearance in cystic fibrosis.

PMID- 1031909
TI  - Rheological factors in mucociliary clearance. The assessment of mucotropic agents
      using an in vitro model.

PMID- 1031910
TI  - The relation of structure to function in gastric mucus.

PMID- 1031911
TI  - Some physical properties of mucins and their molecular origin.

PMID- 1031912
TI  - Studies of mucus permeability. Water transport through intestinal mucus layers.

PMID- 1031913
TI  - Goblet cells and secretion of mucus.

PMID- 1031914
TI  - Synthesis and intracellular transport of glycoproteins.

PMID- 1031915
TI  - Morphological and biochemical approaches to characterize the structure and
      function of the golgi complex.

PMID- 1031916
TI  - Glycosyltransferases and hypersecretion of respiratory mucus.

PMID- 1031917
TI  - [Structural interpretation of a supposed symptomatic schizophrenia].
AB  - A short text spoken by a patient with a supposed symptomatic schizophrenia in
      lupus erythematodes is analyzed by means of a structural interpretation. While
      the text appears schizophrenic, it is only the confusion and intermingling of
      five quite distinct textual levels which create this impression. These five
      levels are presented in three distinctive modes of narrative. (1) Deviation and
      periphrase: while psychopathologically these breaks in the narrative are
      deviations from the main thread of argument, stylistically they are periphrasic
      statements, all having identical structures. They are all related emotionally as
      well as thematically to the central subject of the text. Their informational
      quality is impaired by their density and their interlocked form. (2) Narrative:
      the text contains three meaningful and well-arranged stories. In one case a
      multilevel narrative structure is employed. Each story represents a response to
      the initial question. (3) Metalanguage: on a metatextual level, the patient
      repeatedly makes reference to her linguistic peculiarities. These statements
      coincide with objective evaluation. Delusions and misidentification of
      individuals and situations used in classical psychopathological diagnosis can be
      given a different meaning (in the sense used by Weinrich) if interpretation has
      deepened the knowledge of the text. In this case, the similarity to schizophrenic
      texts is only superficial. A more detailed analysis illustrates the difference
      from schizophrenia on every level.

PMID- 1031918
TI  - [Double suicide and symbiontic psychosis (suicide a deux and folie a deux)].
AB  - Symbiontic psychoses (induced delusions) are marked by 'solitude by twos'-
      together in alienation to the environment. This special psychological situation
      is dangerous and the foundation to develop 'suicides by twos' (double suicides).
      The relations between the psychotic partners (domination-subordination) change
      over to relations of double suicide (instogator-participant). The presuicide
      syndrome of such double suicides is described with two cases, one at the
      psychopathological borderline to a symbiontic psychosis, the other on the
      culmination of it (delusion of influence and reference).

PMID- 1031919
TI  - Season of birth and Schneider-oriented diagnosis of affective disorder.
AB  - Most earlier studies and all recent studies on national samples have shown that
      compared with live births in the control population, schizophrenic patients have
      a significant excess of birth rates in the winter or early months of the year. In
      contrast, only some of the early research efforts and only some of the national
      studies (in England and Wales as well as for certain decades in Sweden) have
      demonstrated that the same holds true for patients with affective psychosis. The
      present German study, carried out on affective disorder diagnosed in a strongly
      Kurt Schneider-oriented clinic, found (as did most Scandinavian research on
      national samples) that there was no significant overrepresentation of births in
      the winter or early months of the year for all types of affective disorder,
      neurotic as well as psychotic. Thus, the findings on Schneider-diagnosed
      affective disturbances were similar to those on Schneider-diagnosed schizophrenia
      reported elsewhere.

PMID- 1031920
TI  - Death anxiety in normal children and adolescents.
AB  - Instruments devised to measure death anxiety, depression, and manifest anxiety in
      adults were administered to 75 junior high-school students, 111 senior high
      school students, and 38 adults in an effort ot determine the nature of any
      developmental differences among these groups. A number of significant differences
      were noted, with the senior high-school students showing greater anxiety,
      depression, and death anxiety than the other groups. These results are discussed
      in the context of tasks of adolescent development, and an item analysis of the
      death anziety questionnaire is presented. Developmental differences in the origin
      of death anxiety are related to previous studies of death anxiety in adults.

PMID- 1031921
TI  - [Leukocyte count in manics, endogenous depressive, schizophrenics and neurotics].
AB  - Manic, endogenous depressive, schizophrenic and neurotic patients, 80 (40
      females, 40 males) in each diagnostic group, are compared with regard to the
      white blood count with one another and with normal controls. Significant
      differences of means were found (1) between some groups of patients concerning
      the total number of leucocytes (micrometer +/- microseconds, micronD), the number
      of neutrophil granulocytes (micrometer +/- microsecond, micronN), the number of
      eosinophil granulocytes (micrometer +/- microseconds, micronD; micronN +/-
      microseconds, micronD) and the number of lymphocytes (micronN +/- micronD), and
      (2) between all groups of patients and normal controls concerning the number of
      monocytes (micronD, micronN, micrometer, microsecond +/- micronK). The findings
      are discussed.

PMID- 1031922
TI  - Possible mechanism of rate-dependent change of contraction in dog ventricular
      muscle: relation to calcium movements.

PMID- 1031923
TI  - Dynamics of contraction with special reference to calcium.
AB  - Using a new method for tetanizing frog ventricle muscle, the tension-length,
      force-load-velocity, and load-extension relations were determined under the
      steady active state. On the basis of these experiments a mechanochemical model
      was developed. Time courses of internal calcium concentrations, the rates of
      release, and uptake of calcium during isometric twitches were calculated by the
      model.

PMID- 1031924
TI  - Isometric dynamic response of mammalian heart muscle due to step changes in the
      calcium concentration of the perfusing medium.
AB  - The isometric tension transient response of isolated kitten papillary muscle was
      found to exhibit direction-dependent dynamics when subjected to step changes in
      the calcium concentration of the bathing medium. The tension transient curves
      could be resolved into a minimum of two to three exponential components, which
      could be considered to indicate different calcium compounds or compartments
      within the muscle. However, a model relating calcium diffusion across the muscle
      to the dose-response curve indicates that the exponential components of the
      tension transient curves are due to the properties of calcium diffusion through
      the extracellular space, and that the direction-dependent dynamics are caused by
      the nonlinearity of the dose-response curve.

PMID- 1031925
TI  - Contraction duration and diastolic stiffness in aged canine left ventricle.
AB  - The data obtained from groups of young and old beagles demonstrate that senescent
      beagle hearts are characterized by lower contractile function as measured by
      developed pressure and maximal rate of pressure change with time, by longer
      contraction duration, and by increased dynamic stiffness per given pressure as
      measured by the sinusoidal forcing technique.

PMID- 1031926
TI  - Delay in diastolic restitution of full myocardial contractility in guinea pig
      atrium.
AB  - In an isolated perfused left atrium of guinea pig, pressure amplitudes were
      recorded at 37 degrees C and a stimulation rate of 240/min with interposed
      variable resting pauses. After prolonged intervals the preparation develops
      maximum pressure, which does not depend on perfusion time or on any positive
      inotropic intervention. The latter is found to shorten the time needed for
      restitution of full contractility. Nifedipine (5 X 10(-7)M) exerts its negative
      inotropic effect mainly by a delay in restitution time; acetylcholine (2 X 10(
      7)M), by a concomitant reduction of all pressure amplitudes over the whole range
      of stimulus intervals. The latter effect is similar to that of lowering [Ca2+]o.

PMID- 1031927
TI  - Subcellular localization of cardiac adenylate cyclase: sarcolemma or sarcoplasmic
      reticulum?

PMID- 1031928
TI  - Voltage-clamp experiments by double microelectrode technique in rabbit sinoatrial
      node cell.
AB  - When a man-made strand of the rabbit sinoatrial node (S-A node) was shortened by
      ligation, the spatial decay of the electrotonic potential decreased and the input
      impedance increased. A satisfactory voltage clamp was achieved in the small S-A
      node specimen using the double microelectrode technique (Deck, Kern, and
      Trautwein, 1964).

PMID- 1031929
TI  - Interaction of lanthanides with muscle microsomes.
AB  - The interaction of gadolinium, a lanthanide with calcium-blocking action, with
      isolated muscle microsomes has been studied. Two classes of binding sites were
      present, 80 and in excess of 300 nmol/mg in number, respectively. Divalent
      cation, including Ca, Zn, and Cd, blocked the higher affinity site. Antibiotic
      ionophores X537A and A23187 enhanced binding, with positive cooperativity. ATP
      enhanced binding at low concentration (10-20 muM) of nucleotide, and without ATP
      hydrolysis. The data suggest a dissociation in the intact membrane between the
      binding and ATP-hydrolytic portion of the transport site.

PMID- 1031930
TI  - A new spectroscopic approach to cardiac energy metabolism.
AB  - The optical characteristics of the hemoglobin-free perfused rat heart have been
      examined in detail. For dual-wavelength spectrophotometry, absorption pairs at
      605-620 nm and 587-620 nm are found to be suited for the investigation of the
      oxidation-reduction changes of cytochrome aa3 and oxygenation-deoxygenation of
      myoglobin in cardiac tissue. Techniques by which the absorption changes of
      myoglobin and cytochrome aa3 can be measured during one cycle of contraction
      relaxation are presented. The results demonstrate that, in the aerobic state,
      myoglobin is more oxygenated during the systolic and diastolic periods and
      deoxygenated in the resting period, whereas cytochrome aa3 is more reduced in the
      systole and diastole and oxidized in the resting period.

PMID- 1031931
TI  - Role of slow inward current on premature excitation in ventricular muscle.
AB  - Action potential durations in premature excitations showed paradoxical
      prolongation at the shorter coupling intervals; this was abolished by manganous
      ions. Voltage-clamp experiments also disclosed a transient increase of slow
      inward current in premature excitations. These results indicate that prolongation
      of action potential durations was mainly brought about by changes in slow inward
      current, especially in its characteristics of recovery from inactivation.

PMID- 1031932
TI  - Significance of heat loss in energetics of left ventricle.
AB  - Left ventricular heat loss was examined by measuring the temperatures in the
      coronary sinus blood, in the aortic blood, and in the left atrial blood by
      thermistors. The temperature was highest in the coronary sinus blood, in the
      aortic blood next, and it was the least in the left atrial blood. However, since
      the aortic blood flow was naturally higher than the coronary sinus blood flow,
      the heat loss was larger in the left ventricular cavity than in the rest of the
      chambers. This heat loss was mostly proportional to the magnitude of the changes
      of both the arterial blood pressure and the aortic blood flow.

PMID- 1031933
TI  - Myocardial adenine nucleotides after infusion of adenosine.
AB  - In the rabbit heart, continuous infusion (12 ml/hr) of 1% adenosine into the
      superior caval vein, or of 0.5% adenosine into the left myocardial ventricle, for
      a period of 3 hr increased the myocardial tissue level of ATP by almost 40% over
      the control (5.0 mumol/g). Both shorter or longer periods of application and
      lower or higher concentrations of adenosine, as well as the infusion of adenosine
      into the left atrium, were less effective. The increase markedly outlasted the
      period of application of adenosine. It did not result from the adenosine-induced
      systemic hypotension and decrease in cardiac work, but must be attributed to a
      direct metabolic effect of the adenosine infusion.

PMID- 1031934
TI  - Transmural mitochondrial differences in myocardium.
AB  - Two functional mitochondrial populations with different sedimentation rates (S)
      were obtained from homogenates of canine myocardium by rate zonal centrifugation
      using an iso-osmotic Ficoll gradient. To ascertain the origin of these
      populations, the left ventricular wall of normal myocardium was divided into
      subepicardial (outer one-third), intermediate (middle on-third), and
      subendocardial (inner one-third) layers. The slow S mitochondria comprised 75% of
      the mitochondrial population of the subepicardial layer. In contrast, the fast S
      mitochondria contributed 65% of the subendocardial population. Intermediate layer
      mitochondria resembled those of the subepicardium. Mitochondria isolated from the
      three layers had approximately the same density, as shown by isopycnic zonal
      centrifugation. These studies indicate that mitochondria from subepicardial and
      subendocardial layers of normal myocardium differ in size and shape but not in
      density. Electron micrographs (EM) of the subepicardium showed many mitochondria
      as long as 4 to 8 sarcomeres. Mitochondria from the outer and inner layers of
      normal myocardium had the same oxidative phosphorylation parameters. Acute
      myocardial infarction, lasting 1 or 2 hr, resulted in the selective loss of the
      fast S mitochondria. Because the fast S mitochondria are prevalent in the
      subendocardium, these results may explain the greater vulnerability of this layer
      to anoxia.

PMID- 1031935
TI  - Uptake and release of immunoreactive insulin in coronary circulation in man:
      studies at rest, during exercise, and during glucose and insulin infusions.
AB  - Significant uptake and release of immunoreactive insulin by the heart have been
      observed in man, and this is related to plasma insulin levels. Exercise and the
      fed state appear to affect the myocardial handling of insulin. The findings could
      not be related to myocardial carbohydrate metabolism, but could, during exercise,
      be related to myocardial lipid metabolism.

PMID- 1031936
TI  - Influence of carbocromene on free fatty acid metabolism of the heart.
AB  - In view of the fact that carbocromene (C) influences the metabolic processes in
      the heart muscle, its effect on the transport of substrates into the heart tissue
      was investigated. In rat heart slices C inhibits the uptake of [1-14C]palmitic
      acid up to 40%, while 14CO2 production is reduced to the same extent. At the same
      time oxygen consumption diminished by about 20%. Using 3-O-[14C] methyl-D-glucose
      as metabolic marker it was shown that the uptake of glucose into the heart tissue
      increased by 30% under the influence of C. From these results it can be concluded
      that C inhibits the oxidation of FFA in favor of glucose and diminishes the
      oxygen-wasting effect of FFA.

PMID- 1031937
TI  - Metabolism of individual fatty acids in heart muscle.
AB  - We have studied the incorporation of various long chain fatty acids into tissue
      lipids using various heart preparations. We found that individual fatty acids are
      incorporated into various lipid fractions at unequal rates. In particular, erucic
      acid was shown to be a poor acyl donor for various acylation reactions. Labeling
      of triacylglycerol by exogenous fatty acid was found to be extremely rapid in the
      perfused rat heart and in the in vivo heart.

PMID- 1031938
TI  - Myocardial fatty acid and cardiac performance.
AB  - Isoproterenol enhanced myocardial triglyceride utilization and incorporation of
      exogenous fatty acid into triglyceride fraction in the perfused rat heart in the
      presence of glucose. However, in the absence of glucose, cardiac performance was
      considerably aggravated by isoproterenol. This suggests that glucose might be an
      essential fuel in the heart stimulated by isoproterenol.

PMID- 1031939
TI  - Free fatty acid content of myocardial interstitial spaces of dog.
AB  - Morphological and biochemical observations from our laboratory have shown the
      presence of lipids in the cardiac interstitial spaces of the dog. The present
      study was designed to assess the importance of free fatty acids (FFA) in these
      lipids using FFA or sucrose tracers in 14 anesthetized fasting open-chest mongrel
      dogs. Endogenous FFA and labeled tracers were measured in arterial and coronary
      sinus plasma; they were also determined in lymph collected from cardiac efferent
      lymphatic trunks. [14C] sucrose was infused at a constant rate in the femoral
      vein of 5 dogs. The concentration of the tracer in the lymph was 90% of the
      arterial concentration after 60 min of infusion. On the other hand, when [1-14C]
      palmitate was infused at the same rate in 7 dogs, the ratio of lymph to arterial
      tracer concentration was only 20% (60 min) and 25% (120 min), even though the
      myocardial extraction and oxidation of the tracer were stable. This ratio tended
      to reach a plateau (greater than or equal to 90%) only 24 hr after a bolus
      injection of the tracer. This tracer study shows the presence of a pool of
      myocardial fatty acids with a relatively slow turnover rate that may constitute
      an important reservoir of FFA.

PMID- 1031940
TI  - Effects of hypoxia and digitalis glycosides on myocardial stiffness.
AB  - The influences of hypoxia and of the interactions of hypoxia with digoxin and
      ouabain on myocardial stiffness were studied at two extracellular calcium
      concentrations (2.5 mM and 4.0 mM) in isolated, isometrically contracting cat
      papillary muscles. Stiffness (delta T/delta L), defined as a change in tension
      (delta T) in response to an imposed length change (delta L), was measured during
      contraction and during rest by use of a sinusoidal forcing function. Neither
      digoxin, ouabain, nor increased extracellular calcium altered contraction or
      resting stiffness in the well-oxygenated environment. Resting stiffness was
      increased at the end of hypoxia only in the presence of digoxin in both 2.5 mM
      and 4.0 mM Ca. Contraction stiffness was increased in 2.5 mM Ca by hypoxia alone
      and by hypoxia in the presence of digoxin or ouabain, but was not increased in
      experiments carried out in 4.0 mM Ca. Thus it appears that hypoxia per se
      increases contraction stiffness, but increasing extracellular calcium from 2.5 mM
      to 4.0 mM prevents the increase elicited by hypoxia; resting stiffness, however,
      is increased by hypoxia only in the presence of digoxin, and this occurs in both
      2.5 mM and 4.0 mM Ca.

PMID- 1031941
TI  - Effect of diltiazem on calcium- and noradrenaline-induced contractions in
      isolated rabbit aorta.
AB  - The effect of diltiazem on calcium- and noradrenaline-induced contractions was
      investigated in the K-depolarized aortic strip of the rabbit. Diltiazem inhibited
      the contraction induced by calcium ions dose-dependently. A lower concentration
      of diltiazem produced no significant influence on the contraction induced by
      noradrenaline, while a higher concentration suppressed it. It is assumed that in
      the rabbit aorta diltiazem effectively inhibits the contraction mediated by the
      influx of calcium ions but it is less effective with the contraction induced by
      the release of sequestered calcium.

PMID- 1031942
TI  - Effects of insulin on mammalian cardiac muscle.
AB  - Insulin increases the contractile force of myocardium with hyperpolarization and
      a faster rate of fall of the action-potential plateau. This phenomenon is
      augmented inthe reduced-K+ or ouabain solution. It is suggested that the insulin
      induced positive inotropism can be explained by facilitation of inward movement
      of Ca2+, which possibly is associated with an increase in outward movement of K+.

PMID- 1031943
TI  - Electrically induced automaticity in canine ventricular myocardium.
AB  - Repetitive spontaneous action potentials (SAP) could be induced in canine
      ventricular and atrial muscle, although this inhibitory action was antagonized by
      the pretreatment with voltage range between about -60 mV and 0 mV. The SAP seemed
      dependent on both slow inward Ca2+ and Na+ currents and was suppressed by
      verapamil, Mn2+, and diltiazem, but not by tetrodotoxin. The increase of
      extracellular potassium concentration also suppressed the SAP. Acetylcholine
      could not block the SAP in ventricular muscle, but inhibited that in atrial
      muscle, although this inhibitory action was antagonized by the pretreatment with
      atropine. The automatic activity was attributed to slow inward Ca2+ and Na+
      currents modified by decreasing time-dependent K+ outward current and K+
      anomalous rectification.

PMID- 1031944
TI  - Inotropic and chronotropic effects of antiarrhythmic agents onisolated blood
      perfused canine ventricular tissue.
AB  - In the isolated blood-perfused canine ventricular tissue, antiarrhythmic agents
      could be classified as having: 1) positive chronotropic and inotropic effects
      (procainamide), 2) negative chronotropic but positive inotropic effects
      (quinidine), and 3) negative chronotropic and inotropic effects (lidocaine,
      ajmaline, diphenylhydantoin, and propranolol).

PMID- 1031945
TI  - Influence of quinidine on ATP-linked calcium binding by heart mitochondria and
      microsomes.
AB  - The action of quinidine on heart microsomal and mitochondrial calcium binding in
      the presence of MgATP was studied under different experimental conditions and
      compared with other antiarrhythmic agents such as procaine amide and lidocaine.
      Quinidine stimulated microsomal calcium binding but depressed mitochondrial
      calcium binding. Although procaine amide stimulated microsomal calcium binding,
      it did not affect mitochondrial calcium binding. On the other hand, lidocaine
      depressed calcium binding by mitochondria without affecting calcium binding by
      the microsomal fraction. The stimulation of microsomal calcium binding by
      quinidine was not apparent at high concentrations of Mg2+, low concentrations of
      ATP, or low concentrations of Ca2+. The depressant action of quinidine on
      mitochondrial calcium binding was not observed at low concentrations of Mg2+ or
      ATP but was more pronounced at low concentrations of Ca2+. These results suggest
      that the action of quinidine on mitochondria may play a major role in eliciting
      cardiodepressant effect.

PMID- 1031946
TI  - Effects of halothane anesthesia on myocardial contractility, coronary as well as
      systemic hemodynamics, and myocardial metabolism in dogs.
AB  - Halothane depressed coronary and other systemic circulations as arterial
      halothane concentration rose in dogs. Myocardial oxygen consumption decreased as
      the cardiac action, especially "myocardial contractility", was depressed, while
      the whole-body oxygen usage remained steady. Lactate and pyruvate levels in
      arterial, mixed venous, and coronary venous blood did not show any signs of
      tissue hypoxia or development of anaerobic metabolism even in very deep halothane
      anesthesia. Coronary blood flow seemed well maintained for the demand, and
      changed almost in parallel with the myocardial oxygen consumption during the
      observation.

PMID- 1031947
TI  - Effects of morphine and halothane on canine cardiac function before and after
      cardiopulmonary bypass.
AB  - In an effort to compare the effects of anesthetics on cardiac functions and
      metabolism, mongrel dogs were anesthetized with morphine (3 mg/kg, N2O 50% in
      oxygen) or halothane (0.7%, N2O 50% in oxygen). Hb, Ht, pO2, pCO2, pH, O2
      content, lactate, and pyruvate in the arterial and coronary sinus blood were
      measured and ECG, LVP, CVP, AP, and CO were recorded. Aorta was cross-clamped for
      30 min under cardiopulmonary bypass (CPB). Hemodynamic and metabolic survey were
      continued until 120 min of recovery period. Results were as follows:
      Hemodynamics, such as LVP, AP, and CO, were depressed after CPB, then gradually
      returned to control level. Subendocardial ischemia observed through ST depression
      and QRS widening on ECG, as well as DPTI/TTI ratio under 1.0, disappeared in the
      recovery period. Lactate was produced by the heart after anoxic arrest and was
      extracted at 120 min after CPB. Halothane and morphine did not show any
      significant differences of effects on cardiac function and metabolism in this
      study.

PMID- 1031948
TI  - Glycolytic ATP and its production during ischemia in isolated Langendorff
      perfused rat hearts.
AB  - The perfused rat heart was used to assess the possible contribution of
      glycolytically produced ATP to the maintenance of the action potential in the
      normoxic heart, and to the maintenance of membrane integrity in the
      underperfused, ischemic heart. During normoxia, pyruvate (10 mM) was nearly as
      able as glucose (10 mM) to maintain the normal action potential. During ischemia
      (reduction of perfusion pressure of Langerdorff heart from 100 to 20 cm H2O),
      total tissue values of ATP and creatine phosphate were similar in pyruvate and in
      glucose hearts. However, pyruvate-perfused hearts had higher tissue levels of
      cyclic AMP during the ischemic period, and during the reperfusion period they had
      an increased release of lactate dehydrogenase and an increased incidence of
      arrhythmias when compared with glucose hearts. It is proposed that these
      differences can be related to a higher rate of production of glycolytic ATP. The
      anatomical, biochemical, and pharmacological evidence favoring a cytoplasmic
      compartment of ATP located in relation to the cell membrane is reviewed.

PMID- 1031949
TI  - Chronotropic effects of calcium and magnesium ions at different temperatures.
AB  - In the isolated right atrium of rabbit hearts, excess calcium causes an increase
      of heart rate at 38 degrees C; this effect is absent or even reversed at a
      temperature of 30 degrees C. From microelectrode studies it seems that when the
      calcium concentration is increased the pacemaker shifts within the sinoatrial
      node to cells in which excess calcium causes an acceleration of diastolic
      depolarization (type A). In fibers where the impulse originates at low calcium
      (type B), excess calcium causes a deceleration of diastolic depolarization. At
      low temperature, the effects on type A fibers are completely absent. Excess
      magnesium has a negative chronotropic effect at both temperatures, mainly by a
      deceleration of diastolic depolarization in type B fibers.

PMID- 1031950
TI  - Alteration in calcium metabolism in mitochondria isolated from ischemic and
      reperfused myocardium.
AB  - This study determines the effect of ischemia and reperfusion on energy-linked
      Ca2+ uptake by myocardial mitochondria. The left anterior descending coronary
      artery was occluded in 14 mature pigs for 2 hr. In seven animals the ligature was
      released and the ischemic zone reperfused for 2 additional hours. After
      sacrifice, mitochondrial function was measured in normal and reperfused or
      ischemic areas of the left ventricle, using a polarographic method. Mitochondria
      were prepared without EDTA by standard procedures and Ca2+ uptake measured by
      45Ca2+ isotope tracer. Uptake of Ca2+ by mitochondria derived from ischemic
      myocardium is markedly impaired with or without phosphate. Reperfusion may
      accentuate this impairment. The presence of exogenous Ca2+ inhibits the ability
      of ischemic or reperfused mitochondria to phosphorylate ADP.

PMID- 1031951
TI  - Relationship between energy liberation and utilization in ischemic cardiac
      muscle.
AB  - Mitochondrial respiration, succinate dehydrogenase coenzyme Q reductase, and
      myosin B were investigated in ischemic myocardium from experimental myocardial
      infarction in dogs. Respiratory control ratio of mitochondria was impaired by
      ischemia at 60 min after coronary ligation, and oxygen consumption was inhibited
      120 min later. Enzyme activity of succinate dehydrogenase coenzyme Q reductase
      was decreased at 6 hr after coronary ligation. Calcium ion sensitivity of myosin
      B declined 12 hr after coronary ligation. However, adenosine triphosphatase
      activity of myosin A from infarcted myocardium was not different from that of the
      intact one. These results suggest that interaction in the sequence of enzyme
      complexes was first impaired in ischemic myocardium and that deterioration of
      enzyme activity was then manifested.

PMID- 1031952
TI  - An experimental study of the effect of glucose-insulin-potassium solution on
      energy metabolism of infarcted cardiac muscle.
AB  - The effect of GIK (glucose-insulin-potassium) infusion on the energy liberation
      of the infarcted heart muscle was studied experimentally in relation to
      epicardial electrocardiographic changes and cardiac dynamics. In the case of 30
      min coronary ligation, the spread of the zone showing ST segment elevation was
      not depressed significantly, but the mean voltage values of ST elevations were
      suppressed in the peri-infarcted area, and the uncoupling of oxidative
      phosphorylation in the peri-infarcted area was also obscured by the GIK
      treatment. Cardiac dynamics did not change with GIK treatment. On the other hand,
      in the 60-min coronary ligation, the spread of the zone showing ST segment
      elevation was reduced significantly and the negative inotropism induced by
      coronary ligation was suppressed with GIK infusion. However, the uncoupling of
      oxidative phosphorylation in the infarcted area and in the peri-infarcted area
      did not show any significant improvement. Therefore, the disturbed energy
      metabolism of the peri-infarcted area of 30-min ligation might be improved by the
      effect of GIK infusion. These data suggested that the GIK infusion improved the
      energy liberation of the so-called twilight zone at 30 min after ligation, and
      then reduced the genuine infarcted zone after 60 min of ligation.

PMID- 1031953
TI  - Effect of xanthine oxidase inhibitor on myocardial ischemia.
AB  - The xanthine oxidase inhibitor, 4-hydroxypyrazolo(3,4-d) pyrimidine (HPP),
      Allopurinol, caused augmentation of myocardial uptake of [3H] hypoxanthine, which
      was eventually completely incorporated into ATP. The decrease of [32P]
      orthophosphate incorporation into ATP induced by isoproterenol was restored by
      HPP administration.

PMID- 1031954
TI  - Calcium paradox: changes in high-energy phosphate compounds of isolated perfused
      rat hearts.
AB  - When isolated rat hearts are perfused with Ca2+-containing medium, after a brief
      Ca2+-free period, irreversible cell damage occurs (calcium paradox). This
      phenomenon is concomitant with a rapid consumption of myocardial high-energy
      phosphate stores, prior to the appearance of these compounds in the effluent
      perfusion medium. A possible mechanism for the origin of myocardial necrosis,
      caused by intracellular Ca2+ overload, is discussed.

PMID- 1031955
TI  - Influence of ATP or oxygen plus substrate on occurrence of the calcium paradox.
AB  - Reperfusion of Ca2+-deprived rat hearts with Ca2+-containing medium results in
      irreversible cell damage (calcium paradox). In this study this type of cell
      damage was studied in the anoxic rat heart, in the presence and absence of
      glucose. Creatine kinase (CK) release was used to define cell damage. Hearts were
      perfused successively with Ca2+-containing medium (30 min), Ca2+-free medium (5
      min), and Ca2+-containing medium (5 min). In the presence of glucose, myocardial
      ATP was maintained at a fairly high concentration. Reperfusion with Ca2+ resulted
      in an immediate and massive release of CK. In the absence of glucose, the ATP
      concentration was almost zero after 30 min. Reperfusion with Ca2+ did not result
      in release of CK. Massive release occurred as soon as these hearts were
      reoxygenated. It is concluded that this type of calcium-induced cell damage only
      occurs in the presence of ATP, or oxygen plus substrate. Mitochondria most likely
      play a major role in the occurrence of the calcium paradox because of their
      ability to accumulate huge amounts of Ca2+ under these conditions.

PMID- 1031956
TI  - Role of myocardial lipids in development of cardiac necrosis.
AB  - Significant alterations in fatty acyl composition of cardiac phospholipids and
      neutral lipids are induced by dietary cod liver oil in the rat. Increased dietary
      availability of docosahexaenoic acid (22:6 omega3) leads to extensive replacement
      of linoleic acid (18:2omega6) and arachidonic acid (20:4omega6) in phospholipids.
      Dietary cod liver oil (10%) reduces isoproterenol stress tolerance and results in
      increased development of cardiac necrosis and mortality following isoproterenol
      treatment. It is suggested that diminished catecholamine stress tolerance may be
      related to altered synthesis of prostaglandins or related products.

PMID- 1031957
TI  - Energy liberation in abnormal cardiac muscle.
AB  - Uncoupling of oxidative phosphorylation was suggested in experiments using the
      infarcted myocardium, even in dogs with 15-min ligation. The same type of
      disturbance in mitochondrial respiration was observed in dogs with reperfusion
      after 45-min ligation, whereas the disturbance was recovered in dogs with
      reperfusion after 15-min ligation.

PMID- 1031958
TI  - Myocardial energy and electrolyte metabolism during exercise in patients with
      circulatory disease.

PMID- 1031959
TI  - Disturbance of myocardial energy liberation in experimental charcoal embolism of
      canine pulmonary artery.
AB  - Experimental charcoal embolism of the pulmonary artery was produced in dogs.
      Changes in hemodynamics, electrophysiology, and cardiac energy liberation were
      observed. The effects of histaminic and antihistaminic drugs on these changes
      were also studied. After two infusions of charcoal suspension, acute right
      ventricular overloading was recognized hemodynamically and
      electrophysiologically. Mitochondria isolated from both ventricles exhibited
      uncoupling of oxidative phosphorylation polarographically. These changes were
      enhanced with histamine injection and reduced with diphenhydramine injection.
      Histamine was seen to have some uncoupling effects on the heart mitochondria and
      a slight effect on cardiac dynamics. It is concluded that oxidative
      phosphorylation of the heart mitochondria was uncoupled in the acute stage of
      experimental pulmonary embolism, and that histamine might emphasize this change
      directly or indirectly or both, that is, directly affecting the myocardial cell
      metabolism, and indirectly aggravating myocardial hypoxia through pulmonary
      vasoconstrictive action.

PMID- 1031960
TI  - A bacterial cardiotoxin: thermostable direct hemolysin produced by Vibrio
      parahaemolyticus.

PMID- 1031961
TI  - Stopping of spontaneous beating of cultured mouse and rat myocardial cells by a
      toxin (thermostable direct hemolysin) from Vibrio parahaemolyticus.
AB  - Low concentrations of thermostable direct hemolysin from Vibrio parahaemolyticus
      stopped the spontaneous beating of cultured mouse and rat myocardial cells. These
      low concentrations depolarized the maximal diastolic potential and inhibited the
      generation of action potential of cultured myocardial cells. The toxin lost its
      activity when preincubated with ganglioside, GT1 or GM1. GT1 was more effective
      than GM1. High concentrations of the toxin caused morphological damage of
      cultured mouse and rat myocardial cells, but did not stop the beating, or cause
      morphological damage of cultured chick myocardial cells.

PMID- 1031962
TI  - Increase in membrane conductance and positive inotropic action of hemolysin
      produced by Vibrio parahaemolyticus on rabbit myocardium.
AB  - The effects of purified thermostable direct hemolysin from the cultured filtrate
      of Vibrio parahaemolyticus on both S-A node cells and atrial cells were studied
      electrophysiologically. Hemolysin caused the membrane conductance to increase,
      thereby causing membrane depolarization. The major ion responsible for this
      depolarization was Na+, but other ions, such as K+ and Ca2+, also participated.
      Positive inotropic action of hemolysin was observed, and the Na-Ca exchange
      mechanism was enhanced after hemolysin treatment.

PMID- 1031963
TI  - Contribution of an electrogenic sodium pump to the response of sinoatrial node
      cells to acetylcholine.
AB  - ACh (10-7) - 10(-6) g/ml) induced hyperpolarization in pacemaker cells in the
      sinoatrial (SA) node of the rabbit heart varied inversely with the level of the
      maximal diastolic potential of the pacemaker cells. The hyperpolarization induced
      by ACh was completely abolished at 4 degrees -6 degrees C. Ouabain (10(-6) g/ml)
      markedly depressed or abolished the hyperpolarizing response. The response was
      also depressed in K-free solution, but not abolished. In Ca-free or low-Na
      solution, the sino atrial node cell responded well to ACh, showing marked
      hyperpolarization. Present results indicate that the hyperpolarization induced by
      ACh is at least in part due to an electrogenic Na pump activated by ACh.

PMID- 1031964
TI  - Selective effects of TTX and verapamil on the upstroke components of the action
      potential from the atrioventricular node.

PMID- 1031965
TI  - Effects of anoxia and metabolic inhibitors on reaction of the fast sodium system.
AB  - The effects of anoxia and metabolic inhibitors on inactivation and reactivation
      of the fast Na system of dog ventricular muscle fibers were studied by examining
      (dV/dt)max of the action potential upstroke. Anoxia for 60 min, dinitrophenol
      (DNP) (2.0 mM), and sodium azide (2.0 mM) depressed markedly steady-state
      (dV/dt)max at each membrane potential produced by changing [K]o. Anoxia tended to
      prolong recovery slightly, but DNP and azide changed little the time course of
      recovery of the (dV/dt)max, which was studied by applying double pulses to elicit
      action potential at different intervals. It is concluded that anoxia, DNP, and
      azide caused prominent depression of the maximum Na conductance but had less
      influence on its recovery kinetics.

PMID- 1031966
TI  - Intraventricular conduction disturbance due to delayed recovery from ventricular
      inactivation in chlorpromazine-treated dogs.
AB  - In in situ canine hearts, chlorpromazine induced a time (preceding cycle length)
      dependent decrease in conduction velocity within the ventricle. Thus, QRS
      duration of nonpremature beats was lengthened at rapid pacing rates while QRS
      duration of atrial premature beats was lengthened at short coupling intervals.
      These slow conductions were not due to reduced take-off potential of ventricular
      action potentials but to drug-induced slow recovery of the rapid Na+ system. The
      phenomenon may be responsible for reported QRS prolongation and fatal ventricular
      arrhythmias encountered in patients receiving phenothiazines.

PMID- 1031967
TI  - Factors accounting for growth and atrophy of the heart.
AB  - Growth of the rat heart was induced by intrathoracic aortic banding, while
      atrophy followed hypophysectomy. During the early phase of hypertrophy, RNA
      concentration increased markedly. During the period of atrophy, RNA concentration
      was reduced. These changes in RNA concentration seemed to account for either the
      increased or the decreased rates of protein synthesis that was observed during
      hypertrophy or atrophy, respectively. Rates of protein degradation were
      unaffected during changes in heart size. These findings suggest that alterations
      in synthesis, processing, or degradation of RNA play a key role in modification
      of heart size.

PMID- 1031968
TI  - Effect of low protein diet on cardiac function and ultrastructure of
      spontaneously hypertensive rats loaded with sodium chloride.
AB  - The effects of low protein diet on cardiac metabolic and structural changes
      subsequent to an extremely high pressure load were investigated. Spontaneously
      hypertensive rats(SHR) were divided into four groups, and fed the following diets
      for four weeks: 1) Group A: regular diet (23% protein) and water, 2) Group B:
      regular diet and 1% saline, 3) Group C: low protein diet (10% protein) and water,
      and 4) Group D: low protein diet and 1% saline. Two weeks after the start of
      feeding, there was no significant difference in the left ventricular
      ultrastructures between the corresponding regular and low protein diet groups.
      Four weeks after, degenerative findings such as streaming of Z lines, dilatations
      of smooth endoplasmic reticulum, and disarrangements of myofilaments appeared
      Group D, while in Group B electron microscopic findings indicated hypertrophy.
      Incorporation of [14C] leucine into the myocardial myosin B in Group D was
      significantly low, with a resulting fall of the LVdP/dtmax per integrated
      isometric pressure (IIP) and a rise of the left ventricular end-diastolic
      pressure (LVEDP), as compared to that in Group C at four weeks after the start of
      feeding. These observations suggest that, in the heart with an extremely high
      pressure load, low protein diet hinders the development of hypertrophy to the
      load with resulting heart failure.

PMID- 1031969
TI  - Ischemic-like change produced in canine heart by atractyloside: a chemical model.
AB  - Experiments were conducted in two canine models. Intracoronary infusion of
      atractyloside resulted in physiological, biochemical, and ultrastructural changes
      similar to those seen with ischemia. The fact that atractyloside, a specific
      inhibitor of adenine nucleotide translocase produces this change in vivo suggests
      that this inhibition in the key disturbance that initiates the metabolic
      derangements seen with ischemia. This chemical model seems to provide unique
      opportunities to study the possible factors that may reverse adenine nucleotide
      translocase inhibition and thus possibly prevent cell injury.

PMID- 1031970
TI  - Effects of L-lactate on glyceraldehyde-3-P dehydrogenase in heart muscle.

PMID- 1031971
TI  - Effects of acetate on myocardial contractility and epicardial ECG of isolated and
      perfused feline hearts.
AB  - In isolated, perfused hearts, the effects of acetate on epicardial ECG and
      ventricular pressure were observed during various times of perfusion. Anions-Cl
      and acetate-caused changes of ECG configuration, especially in the ST segments.
      These were different in Phase I (fast compartment) and Phase II (slow
      compartment).

PMID- 1031972
TI  - Species difference of mitochondrial respiration in experimentally induced heart
      failure.
AB  - In guinea pigs with acute heart failure, a decrease in oxygen consumption (QO2)
      at state 3 and an increase in QO2 at state 4 were seen and the respiratory
      control index (RCI) was markedly lowered; ADP/O ratio was not affected. In
      rabbits with acute heart failure, both RCI and ADP/O ratio showed a statistically
      significant decrease. In dogs with acute and chronic heart failure, no impairment
      of respiratory function of mitochondria was seen. These conflicting results may
      be attributed to the difference in experimental conditions, namely, the species
      difference and the difference in methods to produce experimental heart failure.
      With special regard to species difference, it was confirmed that the RCI of
      myocardial mitochondria of healthy dogs was much lower than that of healthy
      guinea pigs. It is suggested that the difficulty of obtaining intact mitochondria
      may be responsible for the species difference in experimentally induced heart
      failure.

PMID- 1031973
TI  - Experimental studies on the effect of glucocorticoids on cardiac muscle.
AB  - Abnormal electrocardiographic changes were found in some patients on long-term
      glucocorticoid treatment. In experimental animals, chronic glucocorticoid
      administration resulted in an increase of amplitude of the QRS complex and
      abnormal ST and T changes. Changes of action potential were somewhat different in
      the subendocardial and the subepicardial layers. Diffuse mitochondrial
      alterations were found, particularly in the subepicardial layer. In rabbits
      treated with glucocorticoids, no significant changes were found in either serum
      or myocardial potassium content. Slightly decreased Vmax was the observed
      hemodynamic change.

PMID- 1031974
TI  - Transmural gradients in myocardial gas tensions in regionally ischemic canine
      left ventricle.
AB  - Previous studies from this laboratory have demonstrated the usefulness of
      myocardial gas tensions as measured by mass spectrometry for the quantitative
      assessment of regional myocardial ischemia (Khuri et al., 1975a). Progressive
      increases in myocardial carbon dioxide tensions were noted when progressive
      reduction in coronary blood flow was created by means of a variable constrictor.
      The present study was designed to determine if changes in myocardial oxygen and
      carbon dioxide tension were greater in deep, compared to more superficial,
      myocardial layers. In eight anesthetized dogs, progressive reduction in
      circumflex coronary flow was associated with a progressive reduction in
      myocardial oxygen tension and a progressive increase in myocardial carbon dioxide
      tension and intramyocardial ST-segment voltage. Evidence of a transmural gradient
      in the severity of ischemia was present at all degrees of flow reduction. These
      results confirm the findings of previous metabolic studies, which demonstrated
      gradients in lactate and high-energy phosphates. Myocardial carbon dioxide
      tension, which can be monitored continuously by mass spectrometry, would appear
      to provide a useful means of quantitatively assessing changes in regional
      myocardial metabolism.

PMID- 1031975
TI  - Hemodynamic and metabolic changes caused by regional ischemia in porcine heart.
AB  - Myocardial ischemia was induced in the pig by reducing the left anterior
      descending coronary artery (LAD) flow to 26% of its control value. After one
      hour, the LAD was reperfused for 50 minutes. During ischemia and reperfusion,
      cardiac output correlated strongly with arterial levels of lactate and
      nucleosides (all r less than - 0.85). Myocardial inosine production seems to be a
      good marker of ischemia because it correlated very well with myocardial lactate
      production (r = 0.99).

PMID- 1031976
TI  - Changes in intramyocardial oxygen tension and local electrograms produced by
      coronary occlusion.

PMID- 1031977
TI  - Local pulsatile intramyocardial pressure (IMP) as a vector force: simultaneous
      measurements of IMP and tissue oxygen availability.
AB  - A directional nonuniformity of the intramyocardial pressure (IMP) was observed in
      anesthetized open-chest dogs using a piezoelectric pressure sensor implanted in
      the left ventricular myocardium. The nonuniformity seemed to be attributable to
      the variation in myocardial fiber orientation. The IMP, which developed in a
      direction parallel to the base-apex line, was measured in the deep portion of the
      myocardium, simultaneously with local O2 availability. In some cases, IMP
      decreased quickly as soon as a decrement in O2 availability had proceeded only
      slightly as a result of ligation of the anterior descending artery (LAD). In
      other cases, the once decreased IMP recovered gradually even when O2 availability
      remained lowered by continuation of the ligation. These observations indicated
      that IMP had no direct dependency on O2 availability in the case of acute LAD.

PMID- 1031978
TI  - Abnormal myocardial fluid retention as an early manifestation of ischemic injury.

PMID- 1031979
TI  - Metabolic consequences of Sephadex-induced reduction of coronary flow in isolated
      rat heart.
AB  - With a polysaccharide microsphere suspension (Sephadex), coronary flow of
      isolated perfused rat hearts was reduced by approximately 70%. During this
      Sephadex-induced ischemia, the energy charge and creatine phosphate content of
      the myocardial tissue dropped significantly, while total nucleoside and lactate
      release from the heart increased. During hypoxia (30% O2), changes in high-energy
      phosphate content and lactate and nucleoside release were similar to the changes
      induced by ischemia. During hypoxia, coronary flow rate was increased by 47%.
      Thus, Sephadex-induced reduction of coronary flow could be a useful model in
      studies of metabolic change during ischemia.

PMID- 1031980
TI  - Cardiac muscle taurine: effects of acute left ventricular ischemia in the dog and
      anoxic perfusion of the rat heart.
AB  - It has been proposed that taurine, or one of its metabolites, may exert anti
      arrhythmic effects in cardiac muscle. The present studies examined the effects of
      acute left ventricular ischemia in the dog (in vivo) and whole heart anoxia in
      the perfused rat heart (in vitro) on the content and distribution of taurine. In
      control dogs an increasing outer-to-inner gradient in taurine content was
      observed in the left ventricle. Left circumflex artery ligation for four hours
      markedly decreased tissue taurine content, the greatest disappearance occurring
      in the inner zone. Anoxic perfusion resulted in a similar decrease in rat
      ventricular taurine levels. Recovery of taurine in the heart perfusates indicated
      that tissue disappearance, secondary to oxygen deficiency, involved leakage into
      the extracellular fluid rather than metabolic conversion.

PMID- 1031981
TI  - Coronary circulation, myocardial metabolism and hemodynamics of pacing-induced
      angina.
AB  - The following changes were noted during pacing-induced angina: The coronary sinus
      blood flow was less than it was during the control period and less than that in
      the myocardial ischemic group without induced angina. While myocardial oxygen
      consumption did not increase, myocardial metabolism became anaerobic. The
      possibility of myocardial dysfunction also was noted.

PMID- 1031982
TI  - X-ray microanalysis of mitochondrial calcium.
AB  - X-ray microanalytical techniques using wavelength dispersive (WDS) and energy
      dispersive spectrometry (EDS) indicate that Ca2+ is present in intramitochondrial
      granules which occur in myocardial cells following irreversible ischemic injury.
      Preliminary results using tissue prepared for routine electron microscopy suggest
      that the degree of calcium binding that occurs in the mitochondria increases with
      increased duration of ischemia. Free ions are leached out of the tissue during
      processing; hence, the role of ion redistribution in producing myocardial
      necrosis cannot be elicited from a study of this nature. However, with continued
      progress in the development of techniques of tissue preparation x-ray
      spectrometry may provide a means of assessing quantitative ion alterations that
      occur during ischemia.

PMID- 1031983
TI  - Turnover rates of muscle proteins in cardiac, skeletal, and smooth muscle:
      turnover rate related to muscle function.
AB  - The turnover rate of muscle proteins was related to the physiological function of
      the muscle in dogs, fowl, rats, and mice. The turnover rates of mixed muscle
      proteins were most rapid in cardiac muscle, intermediate in red tonic and mixed
      fiber-type muscles, and slowest in white twitch skeletal muscle. This same
      progression in  turnover rates also was shown in the subcellular fractions of
      muscle-sarcoplasmic and myofibrillar proteins-as well as in purified proteins,
      myosin, and tropomyosin. The RNA concentration of muscle was highly correlated
      with the protein turnover rate, and the RNA activity, i.e., the translational
      efficiency of the RNA, was similar in the different muscle types.

PMID- 1031984
TI  - Elemental composition of ischemic myocardium determined by x-ray microanalysis.
AB  - Elemental composition of ischemic myocardium was attempted with x-ray
      microanalysis. Energy dispersive spectrum exhibited calcium K alpha and
      phosphorus K alpha peaks from mitochondrial deposits, and Ca K alpha peaks from
      nucleus, contraction bands, and Z lines of the ischemic myocardial cell. Ca and P
      contents were confirmed with wavelength dipersive spectrometers. Mg was present
      in the mitochondrial deposits which lacked Ca. This study suggests a formation of
      phosphate salt of Ca at different intracellular sites and also of Mg with
      mitochondrial deposits.

PMID- 1031985
TI  - Ultrastructural features of diseased human atrial muscle cells.
AB  - Left atrial myocardial tissues, excised at the time of surgery from 30 Japanese
      patients, were studied using light and electron microscopy and the freeze
      fracture technique. All had mitral valvular disease, and, in 22 (74%) patients,
      atrial fibrillation also was present. In all patients, most of the left atrial
      cardiocytes were hypertrophied and surrounded by various amounts of fibrous
      tissue. Degenerative alterations included large masses of lipofuscin granules and
      lamellar bodies, disorganized myofibrils, widened Z-line material, selective loss
      of thick filaments, and prominent tubules of sarcoplasmic reticulum. A high
      incidence of tubular aggregates was observed in 70% of the cases. Such
      alterations were seen more often in the mitral regurgitation group as compared to
      the mitral stenosis group. Atrial cardiocytes were found to be more susceptible
      to disease processes, such as rheumatic fever and subsequent pressure and/or
      volume overloading, than ventricular cardiocytes. Human atrial cardiocytes may be
      utilized in future cytopathological studies to study the effect of processes
      leading to cardiocyte hypertrophy and degeneration.

PMID- 1031986
TI  - Contribution of myocardial metabolism to the knowledge of myocardial failure and
      myocardial infarction.

PMID- 1031987
TI  - Interrelation of left ventricular function and myocardial ultrastructure as
      assessed by endomyocardial biopsy: comparative study of hypertrophic and
      congestive cardiomyopathies.

PMID- 1031988
TI  - Is there a calcium-caused defect of oxidative phosphorylation in cardiomyopathic
      hamster hearts?
AB  - Mitochondria from cardiomyopathic hamster hearts have elevated calcium levels,
      which may cause a defect of oxidative phosphorylation in a small fraction of
      them. Using a combination of dual labeling density-gradient centrifugation, it
      was not possible to isolate such an abnormal fraction. However, cardiomyopathic
      mitochondria are more susceptible to damage by calcium in vitro, suggesting that
      an abnormal fraction does exist nevertheless.

PMID- 1031989
TI  - Myocardial metabolism of spontaneously hypertensive rat.
AB  - Oxidative phosphorylation of myocardial mitochondria isolated from spontaneously
      hypertensive rats (SHR) was determined polarographically. The concentrations of
      high-energy phosphate compounds, the concentrations of intermediate metabolites,
      and the activities of the enzymes within the metabolic systems of glycolysis, the
      pentose phosphate (PPh) cycle, and the tricarboxylic acid (TCA) cycle of the
      myocardium of SHR were determined. The gradual development of cardiac hypertrophy
      was observed in SHR in comparison with normotensive Wistar rats. There were no
      significant differences in the function of oxidative phosphorylation of the
      mitochondria, in concentrations of high-energy phosphate compounds and
      carbohydrate metabolites, or in activities of glycolytic enzymes between SHR and
      normotensive Wistar rats.

PMID- 1031990
TI  - Reduced response of cardiac norepinephrine release to isometric handgrip exercise
      in heart failure.
AB  - In order to evaluate the relation of cardiac norepinephrine (NE) release to left
      ventricular function, blood was taken simultaneously from the coronary sinus (CS)
      and the aorta (A) in 19 patients with heart diseases, at rest and during
      isometric handgrip exercise (IHG) at 30% of their maximal contraction. Plasma NE
      was analyzed by Renzini's THI method. The concentrations of plasma NE at rest
      were 397 +/- 66 (S.E.M.) ng/liter in CS and 292 +/- 50 in A. IHG significantly
      increased NE to 578 +/- 88 in CS and to 462 +/- 85 in A (p less than 0.001).
      Estimated NE release from the heart (deltaNE = NECS - NEA) correlated inversely
      to left ventricular end-diastolic pressure at rest (r = -0.520, p less than 0.05)
      and during IHG (r= -0.689, p less than 0.01). The changes in deltaNE induced by
      IHG correlated to the slope of the left ventricular function curve (r=0.618, p
      less than 0.01). It is concluded that the response of cardiac NE release to
      exercise is reduced in patients with depressed cardiac function.

PMID- 1031991
TI  - Comparison of the synthesis of light and heavy chains of cardiac myosin.

PMID- 1031992
TI  - Experimental study on enzyme distribution and its relation to myocardial ischemic
      changes following coronary circulatory disturbances.
AB  - Coronary artery ligation of canine heart was performed to investigate the
      relationship between the lactate dehydrogenase (LDH) pattern in myocardium and
      the distribution of coronary flow, especially in the early stage of ligation and
      after reperfusion. In the myocardium of normal dogs, the LDH pattern was similar
      in the left ventricle, the interventricular septum, and the right ventricle; the
      average LD5:LD4 ratio was 1.1, 1.2, and 1.2, respectively, and consisted mainly
      of heart type. In the left and right auricles, however, the ratios were 0.3 and
      0.2, respectively, lacking heart type. In the left ventricle, LD5:LD4 ratio in
      the subendocardium was different from that in the subepicardial layer. Blood flow
      distribution in canine myocardium was investigated by the fluorescent pattern on
      the cut surface of heart, in which 10% fluorescein sodium was injected into the
      cavity. By this method the evolution of the ischemic area from the endocardial
      layer to the epicardial side following coronary artery ligation and the effect of
      reperfusion on the ischemic area were clarified. Electron microscopic studies
      indicated that loss of mitochondrial function may account for the irreversibility
      of myocardial cell alteration. A new method for studying enzyme localization in
      tissues was introduced for studying LDH isoenzyme distribution in normal and
      injured myocardium.

PMID- 1031993
TI  - The influence of plasma volume changes on enzymatic estimation of infarct size.
AB  - In 18 patients, myocardial injury was estimated by mathematical analysis of the
      rise in plasma activity of alpha-hydroxybutyrate (alpha-HBDH) dehydrogenase as
      observed by multiple sampling after admission. This enzyme represents the lactate
      dehydrogenase isoenzymes LDH1 and LDH2. Changes in plasma volume were assessed by
      determining hematocrit values at the same time as the enzyme activities. Infarct
      size was expressed in IU/liter of plasma and in grams of heart muscle per liter
      of plasma (g/liter). Significant changes in plasma volume, reflected in
      hematocrit changes, occurred (average 12%): 10 patients without pulmonary edema
      showed an average change of 7%; for the group of eight patients with pulmonary
      edema, the change was 17%. When calculated infarct size was not correlated for
      plasma volume changes, a significant overestimation occurred (11.7%, range 0.7
      29.7%). In the subgroup of patients with pulmonary edema the mean overestimation
      was 15.8%, and in patients without pulmonary edema, the mean overestimation was
      8.5%. It is concluded that plasma volume changes after an acute myocardial
      infarction have to be taken into account when infarct size is calculated on the
      basis of plasma enzyme levels.

PMID- 1031994
TI  - Changes in purine nucleoside content in human myocardial efflux during pacing
      induced ischemia.
AB  - Pacing-induced myocardial ischemia in 18 patients resulted in an increase of
      coronary sinus hypoxanthine levels from 1.20 +/- 0.18 micron during control to
      2.41 +/- 0.52 micron (p less than 0.025) during pain. In addition, early lactate
      production occurred frequently before angina was noted. Neither hypoxanthine nor
      lactate levels changed in seven nonanginal patients, nor were significant
      alterations in potassium, inorganic phosphate, glucose, or oxygen saturation
      found in all patients. Myocardial hypoxanthine production seems a useful
      indicator of ischemia in the human heart.

PMID- 1031995
TI  - Nucleic DNA and RNA in cardiac muscle cell of experimental myocardial infarct.
AB  - Myocardial infarction was produced in dogs, and the changes in nucleic acid
      synthetic activity were investigated quantitatively by microspectrophotometer in
      the myocardial cells as time progressed. DNA value, immediately after infarction,
      was greatly increased in comparison to that of the control group. At two weeks
      after infarction the value had increased to the highest level. After this point
      the value decreased, and, in 12 weeks, the mean value was back to the control
      level. Changes in RNA followed a pattern similar to DNA changes. The mechanism of
      the repair process of myocardial infarction was investigated.

PMID- 1031996
TI  - Dopamine-beta-hydroxylase activity after acute myocardial infarction.
AB  - After acute myocardial infarction, serial serum dopamine-beta-hydroxylase (DBH)
      activity was elevated in both high and low DBH subgroups. The observed increase
      in DBH activity on the first, second, and third days after acute myocardial
      infarction suggests an augmentation in sympathetic nervous system activity after
      acute myocardial infarction.

PMID- 1031997
TI  - Release of lysosomal enzymes during ischemic injury of canine myocardium.
AB  - The pathobiology of the process of myocardial injury during ischemia comprises a
      series of events that results in the release of lysosomal enzymes from their
      subcellular locations within the myocardium. We have developed a canine model of
      acute myocardial ischemia in which the anterior descending coronary artery is
      ligated, myocardial blood flow is measured using radioactive microspheres, and
      tissues from subendocardium and subepicardium are assayed for activity of
      lysosomal hydrolases:N-acetyl-beta-glucosaminidase (NAG), beta-glucuronidase
      (beta-gluc), and acid phosphatase (AP). Particulate fractions of subendocardium
      revealed significant depletion of of total acid hydrolases (NAG, beta-gluc, and
      AP) after one and two hours of ischemia. In addition, after two hours of
      ischemia, the total activity of these three hydrolases in the subendocardial
      supernatant was decreased, correlating significantly with diminished myocardial
      blood flow (NAG: r =0.96; beta-gluc: r = 0.95; AP: r = 0.75). The diminished
      enzymatic levels in thesupernatant suggested "washout" of the hydrolases that was
      more efficient in those ischemic areas that had higher myocardial flow (greater
      than 20% of control). These changes in distribution of lysosomal hydrolases
      indicate early involvement of these enzymes in the pathobiology of myocardial
      injury and demonstrate the dynamic relationship of "washout" of acid hydrolases
      with the degree of diminished blood flow.

PMID- 1031998
TI  - Pepstatin inhibition of rat myocardial acid protease.
AB  - The protease inhibitor, pepstatin, inhibited acid protease in rat heart
      homogenates with a Ki of 7 x 10(-11) M by a noncompetitive mechanism, but it had
      no effect on myocardial acid protease activity when given in high doses to intact
      animals. Exposure of heart slices to 10(-7) M pepstatin for two hours also failed
      to produce demonstrable acid protease inhibition, suggesting that myocardial acid
      protease activity is unaffected by this potent inhibitor unless the integrity of
      the cell is disturbed.

PMID- 1031999
TI  - Features of lysosomal proteolytic enzyme activity in infarcted myocardium.
AB  - Myocardial infarction was produced in dogs to investigate the behavior of cardiac
      lysosomal enzymes; acid protease and beta-glucuronidase activities were measured
      in whole myocardial homogenate and 30,000 X g supernatant fractions. Total
      activity of acid protease in the whole homogenate of the myocardium increased
      after 1 hr of infarction and showed maximal value after 6 hr, while in the 30,000
      X g supernatant fraction the activity began to increase after 3 hr and reached
      the maximal level by 24 hr. Total beta-glucuronidase activity in the whole
      homogenate decreased during the initial 3 hr after myocardial infarction and
      markedly increased after 12 hr. The activity in the 30,000 X g supernatant
      fraction showed corresponding changes. These findings that the increase in whole
      homogenate activity preceded that in the 30,000 X g supernatant fraction may
      support the hypothesis that lysosomal enzymes may be newly synthesized and then
      solubilized in the infarcted myocardium.

PMID- 1032000
TI  - Autophagy in cardiac myocytes.
AB  - The fetal mouse heart (FMH) in organ culture continues to beat for a period of
      weeks, but degenerative changes occur. Electron microscopy revealed formation of
      autophagic vacuoles containing damaged organelles in some cells after the first
      day, indicating focal cytoplasmic injury. This process was accelerated by
      transient deprivation of oxygen and glucose followed by resupply of oxygen and
      glucose. FMHs were maintained for up to four hours in glucose-free media in an
      atmosphere of 95% N/5% CO2 followed by resupply of O2 and glucose. Twenty-four
      hours later, many cells recovered without residual injury. Many others revealed
      autophagic vacuoles ranging from those in which organelles were readily
      identified to those characteristic of residual bodies. It appears that focal
      injury stimulates the endoplasmic reticulum to enclose the damaged components,
      permitting localized lysosomal digestion without causing injury to the entire
      cell. Autophagy has not been emphasized as an important mechanism in transient
      ischemia in adult myocytes, but it may play a role in repair of sublethal injury.
      The FMH organ culture provides an excellent model for studying the sequential
      autophagic changes in a system in which these events can be accelerated.

PMID- 1032001
TI  - Myocardial protection during open-heart surgery: preservation of myocardial
      metabolism and ultrastructure by cold coronary perfusion.
AB  - Myocardial protection by means of selective, continuous coronary perfusion with
      cold oxygenated blood of low flow rate and of low perfusion pressure is an
      excellent procedure both clinically and experimentally. This method should be
      particularly useful in poor-risk patients, for whom a maximal preservation of the
      myocardium is imperative.

PMID- 1032002
TI  - Myocardial energy metabolism and protection of heart muscle at low temperatures.

PMID- 1032003
TI  - Investigation into the causes of increased protein synthesis in acute hemodynamic
      overload.

PMID- 1032004
TI  - Experimental studies on myocardial metabolism of carbohydrates and lipids in
      surface-induced deep hypothermia.
AB  - In surface-induced deep hypothermia, metabolic acidosis resulting from
      lactacidemia was observed. In the hypothermic heart, the rate of reduction in the
      coronary arteriovenous (A-V) difference ratio of lactate, pyruvate, and
      nonesterified fatty acids (NEFA) was proportionately less than that of coronary
      flow and myocardial oxygen consumption, suggesting that lactate, pyruvate, and
      NEFA play important roles as energy fuels in the hypothermic heart. Myocardial
      metabolism of glucose was reduced; exogenous corticosteroids and ATP do not
      influence the myocardial metabolism of carbohydrates and lipids in the
      hypothermic heart.

PMID- 1032005
TI  - Preservation of myocardial membrane integrity in the early phase of acute
      myocardial ischemia.
AB  - Myocardial uptake of dexamethasone (Dex) or methylprednisolone (MP) was studied
      using tritiated tracers in isolated perfused cat hearts during acute myocardial
      ischemia. Considerable amounts of Dex and MP were incorported into the plasma
      membranes in control, border-zone, and ischemic myocardium. Lesser amounts were
      bound to the remaining subcellular organelles. A gradient of the glucocorticoid
      uptake was observed decreasing from control myocardium to ischemic myocardium in
      all subcellular fractions. By the first hour of ischemia, the myocardial plasma
      membranes underwent marked depletion of activity of 5'-nucleotidase, a plasma
      membrane marker enzyme, indicating early loss of plasma membrane integrity in
      acute myocardial ischemia. The incorporation of Dex or MP into the plasma
      membranes resulted in a significant decrease in loww of 5'-nucleotidase activity
      of the plasma membranes in the border-zone and ischemic myocardium. The data
      provide direct evidence 1) to support a membrane stabilizing action of
      glucocorticoids, and 2) to focus on the plasma membranes as a potentially
      important site of protection during the early phase of acute myocardial ischemia.

PMID- 1032006
TI  - Effect of physical fitness on myocardial damage and circulation after myocardial
      necrosis.
AB  - The effect of physical training (conditioning) on myocardial circulation and
      myocardial damage has been evaluated in experimental myocardial necrosis in
      albino rats. Conditioning was done by making the animals swim in a tank of water,
      thermostatically controlled at 32 degrees +/- 1 degrees C, 60 minutes daily, six
      days a week, for eight weeks. Myocardial necrosis was produced by subcutaneous
      injection of isoproterenol, 85 mg/kg body weight, on two consecutive days.
      Investigations included ECG (lead II), SGOT, SGPT, SLDH, SCPK, histopathology of
      the heart, and myocardial Rubidium 84 uptake. It was observed that, in
      conditioned animals, elevation of serum enzymes was less, incidence of cardiac
      arrhythmia was lower, myocardial damage was less marked, and myocardial
      circulation was better after myocardial necrosis in comparison to unconditioned
      animals. Less myocardial damage and lower incidence of cardiac of cardiac
      arrhythmia are presumably associated with a better prognosis.

PMID- 1032007
TI  - Pharmacological protection of hypoxic heart.
AB  - The ability of beta-adrenoceptor antagonists, with and without intrinsic
      sympathomimetic activity, and of verapamil to protect the heart against hypoxia
      induced damage was investigated. Damage was quantitated in terms of a raised end
      diastolic resting tension and creatine phosphokinase (CPK) release. The results
      indicate that both the d and the l isomers act differently, the isomers
      preventing CPK release and the d isomers preventing the increase in resting
      tension.

PMID- 1032008
TI  - Studies on experimental coronary insufficiency. I. Effects of a physiological
      dose of adrenaline and noradrenaline on myocardial metabolism in dogs with graded
      coronary constriction.
AB  - To investigate the mechanism by which catecholamines produce myocardial ischemia,
      the effect of intracoronary-administered adrenaline and noradrenaline was studied
      in dogs with graded coronary constriction. A physiological dose of catecholamines
      was favorable for augmentation or improvement of myocardial metabolism and
      cardiac function in dogs without or with slight coronary constriction. However,
      in dogs with moderate or severe coronary constriction, similar doses of
      catecholamines produced myocardial ischemia and cardiac dysfunction.

PMID- 1032009
TI  - Studies on experimental coronary insufficiency. II. Effects of beta-adrenergic
      blocking agent (propranolol) on metabolic response to adrenaline and
      noradrenaline in dogs with coronary constriction.
AB  - To obtain further information on the mechanism by which catecholamines produce
      myocardial ischemia, the effects of propranolol on metabolic and mechanical
      responses to adrenaline or noradrenaline were investigated in coronary
      constricted dogs. Propranolol suppressed the myocardial ischemia produced by
      noradrenaline and adrenaline in dogs with moderate coronary constriction.

PMID- 1032010
TI  - Viability and histopathology of eleven fresh, antibiotic-treated allografts
      removed three weeks to three years after implantation.
AB  - Changes in metabolic activity of removed heart valve allografts have been
      measured. The fresh heart valves were sterilized and stored in antibiotic
      solution before implantation in patients. Viability was determined before
      insertion and after removal from patients by two methods: 1) tissue culture, and
      2) autoradiography, using tritiated thymidine. The length of storage in the
      Hank's antibiotic or nutrient-antibiotic medium before insertion did not seem to
      influence the final metabolic activity nor the structural integrity of the
      allografts when they were removed. Results from the present study show that the
      most severe degenerative changes occur in valves stored in Hank's solution and
      then implanted in the mitral position. The viability percentage declined
      progressively during the time that a valve treated in this manner was functioning
      in a patient.

PMID- 1032011
TI  - Coronary microcirculatory factors and cardiac muscle cell injury.
AB  - Coronary artery ligation with or without reperfusion was carried out in Wistar
      rats to study the role of coronary microcirculatory factors and membrane
      permeability alteration of cardiac muscle cell in the evolution of cardiac muscle
      cell injury by using the fine structural extracellular protein tracer,
      horseradish peroxidase (HRP). The findings were compared with those obtained in
      noncoronarogenic myocardial injury models following administration of
      norepinephrine, a pressor, and isoproterenol, a depressor catecholamine.
      Following left coronary artery ligation lastingfor 10 and 20 minutes, some of the
      collaterals in the ischemic zone were perused by the tracer, but the numer of
      patent capillaries decreased during 60-min ligation. The inhomogeneous
      involvement of cardiac muscle cells in ischemic injury correlated well with these
      microcirculatory findings. In comparison to permanent ischemia, an abrupt
      deterioration of the cardiac muscle cell alteration occured after reperfusion
      with influx of HRP into the damaged cells. The binding of tracer to myofilaments
      was, however, a later event as compared to that seen in the catecholamine models.
      The latter observation implies that, in addition to microcirculatory factors,
      direct cardiac muscle cell stimulation should also be considered in the evolution
      of noncoronarogenic myocardial injury.

PMID- 1032012
TI  - The effects of coronary artery ligation on transmural high-energy phosphates
      following 20 minutes of blood reflow.
AB  - Normal or elevated levels of ATP and phosphocreatine (PCr) were observed from the
      subepicardium to the subendocardium of the canine left ventricle after five and
      20 minutes of left circumflex artery occlusion followed by 20 minutes of blood
      reflow. However, after two or four hours of occlusion, followed by reflow, ATP
      and PCr levels were markedly depressed, and a significant decreasing decreasing
      subepicardial to subendocardial gradient appeared, suggestive of inhibition of
      oxidative metabolism during extended periods of ischemia but not during short
      periods of ischemia.

PMID- 1032013
TI  - Transmural gradients in ischemic canine left ventricle: effects of blood reflow
      on glycolytic intermediates.
AB  - Following two and four hours of left ventricular ischemia, 20 minutes of blood
      reflow cannot produce a complete return to normal oxidative metabolism in
      ischemic canine myocardium. Glycolysis remains increased and aerobic metabolism
      is most extensively depressed in the subendocardium.

PMID- 1032014
TI  - Evaluation of perfusion conditions in cardiopulmonary bypass.
AB  - Fresh sections of left ventricular drill biopsies, taken at the beginning and end
      of cardiopulmonary bypass in 164 patients undergoing aortic valve replacement,
      have been analyzed for myocardial function. This has been assessed by changes in
      biochemical function, measured by semi-quantitative histochemical methods, and by
      changes in birefringence, measured quantitatively by polarization microscopy. It
      has been shown that continuous perfusion at 32 degrees C with the heart beating
      provided better preservation than did the other three perfusion procedures, in
      all of which the heart was fibrillating. More recently, in a small number of
      cases, cardioplegic arrest has been found to given even better preservation.

PMID- 1032015
TI  - Ultrastructural change in myocardium subsequent to ischemic cardioplegia "no
      reflow phenomenon".
AB  - Mongrel dogs were subjected to cardiopulmonary bypass with hemodilution and to
      normothermic anoxic arrest for 30 minutes, to study the subepicardial and the
      subendocardial myocardial ultructure and the DPTI/TTI ratio. "No-reflow
      phenomenon" was demonstrated in the myocardium after cardiopulmonary bypass,
      associated with normothermic anoxic arrest. No-reflow phenomenon was a
      contributing factor to subendocardial ischemia in the normotrophied ventricle
      after open-heart surgery. Severe hemodilution with hemoglobin less than 5.0 g%
      resulted in irreversible damage in both myocardial layers.

PMID- 1032016
TI  - Tissue culture of myocardial cells: introductory remarks.

PMID- 1032017
TI  - Effect of environmental factors and tissue culture methodology in producing and
      studying cultured cardiac cells.
AB  - Improvement in the method of heart cell cultures is described and justified in
      relation to environmental factors. The validity of such cardiac cell culture for
      cardiac research is discussed in light of particular cellular activities:
      differentiation of lipoprotein lipase, myoglobin biosynthesis, glucose and fatty
      acid metabolism pleiotypic responses (rotein, RNA, and DNA biosyntheses,
      substrates transports) to serum stimulation, and the architectonic growth of
      muscle and nonmuscle cells.

PMID- 1032018
TI  - The effect of aerobic and anoxic perfusion on protein synthesis in cardiac
      arrest.

PMID- 1032019
TI  - Fetal mouse hearts in organ culture. Studies in cardiac metabolism.

PMID- 1032020
TI  - Palmitate oxidation by beating heart cells in culture.
AB  - Palmitic acid oxidation has been studied in cultures of beating heart cells. The
      data reported suggest: 1. The main source of fatty acids for oxidation in cell
      cultures is provided by lypolysis of preexisting intracellular fatty acids. Most
      fatty acids that have just entered the cell are not oxidized immediately. Thus,
      aged heart cells in culture seem to retain their ability to utilize fatty acids
      as their main energy source. 2. In cultured heart cells, the amount of CO2
      obtained from the carboxyl group was much higher than that obtained from the
      methyl group. On the other hand, beta-hydroxybutrate has been shown to be formed
      mainly from the methyl group. This may indicate that beta-oxidation terminates at
      the beta-hydroxybutyrate stage because of premature dissociation of this last
      intermediate from the enzyme complex.

PMID- 1032021
TI  - Synthesis and phosphorylation of canine cardiac myosin in tissue-culture
      assessment of hypertrophying factors.
AB  - Canine cardiac myosin, which was synthesized in a 14-day tissue culture, based on
      L-[3H] leucine incorporation, was precipitated with goat gamma G antimyosin
      (cardiac-specific) and analyzed on dodecylsulfate gels. Incorporation of 32PO4
      into myosin chains occurring in culture was the same as that obtained in vivo and
      appeared to be coupled with translation. Removal of 32PO4 from myosin heavy
      chains with base treatment indicated the presence of phosphoserine and
      phosphothreonine in canine cardiac myosin heavy chains. Further acid hydrolysis
      confirmed the data. The system described here, i.e., analyses of 32PO4 and L[3H]
      leucine incorporation into myosin heavy chains, could be used as a system for
      assaying hypertrophying factors.

PMID- 1032022
TI  - Pleiotropic effect of serum on beating rat heart cell cultures and their
      modulation by hormones.
AB  - The multiple effects of serum on metabolic activities and macromolecular
      syntheses of heart cell cultures are discussed in this chapter. This pleiotropic
      response, which is linearly related to the amount of serum used, allowed us to
      quantitatively test the growth-promoting activity of different hormones. In
      addition, the possible mediation of the serum effects by cyclic nucleotides is
      considered.

PMID- 1032023
TI  - Ouabain-induced arrhythmias of cultured myocardial cells and their improvement by
      quinidine.
AB  - Single-isolated myocardial cells obtained in vitro from fetal mouse heart
      developed various types of arrhythmic movements, such as fibrillatory and
      fluttering movements, in medium containing ouabain. The percentage of isolated
      myocardial cells that exhibited arrhythmic movements increased as ouabain
      concentration was increased. The arrhythmic movements induced by relatively low
      concentrations of ouabain were reduced by addition of quinidine. Cell clusters
      also developed various types of arrhythmic movements in medium containing
      ouabain. These arrhythmias became more severe when the ouabain concentration was
      increased. Under conditions such that approximately 43% of the single-isolated
      myocardial cells showed arrhythmias, many cells in cell clusters showed
      fibrillatory movements, but the cell clusters as a whole still maintained
      rhythmic beating. Under conditions in which about 65% of the single-isolated
      myocardial cells showed arrhythmias, cell clusters as a whole showed irregular
      beating. The cell clusters stopped beating under conditions in which about 79% of
      the single-isolated myocardial cells showed arrhythmias. Relatively mild types of
      arrhythmias of cell clusters were improved by addition of quinidine. From these
      observations, the genesis and improvement of arrhythmias of cell clusters were
      concluded to be essentially a result of the genesis and improvement of arrhythmic
      movements of the individual component cells in the clusters.

PMID- 1032024
TI  - Experimental studies on cardiac arrhythmias with special reference to
      fibrillation in heart cell culture.
AB  - Fibrillation-like beating of cardiac muscle cells in culture was induced by
      altering the concentrations of various ions. Fine structural changes of cell
      membrane and intercellular alteration of cardiac muscle cells appeared to be more
      prominent in cells with fibrilliation-like beating than in others. From the
      results of the present study, it may be concluded that fibrillation-like beating
      may occur in the presence of altered concentrations of certain ions, accompanied
      by fine structural changes in the cells.

PMID- 1032025
TI  - Myocardial depressant factor and rat heart myoblasts in tissue culture.
AB  - Beating rat heart myoblasts in tissue culture are suitable for the demonstration
      of the effect of sera from patients with cardiogenic shock upon the contractility
      of heart muscle. Shock serum either promptly stops beating or causes
      discoordinated movements of the cultivated myoblasts (fibrillation). This effect
      of the shock serum is concentration-dependent. Hydrocortisone before and/or after
      treatment of the cultivated cells does not influence the effect of the shock
      serum. Calcium ions shorten the period of standstill of the muscle cells after
      washout of the shock serum.

PMID- 1032026
TI  - Morphological evidence for neural control of the activity of rat heart pacemaker.

PMID- 1032027
TI  - Cardiotoxic effects of adriamycin in mammalian cardiac cells in culture.
AB  - Cardiotoxicity of unknown etiology may preclude the use of adriamycin, a cancer
      chemotherapeutic agent. Mammalian cardiac cells in culture were used as a model
      system in the study of the mechanisms involved. Adriamycin inhibited cell growth,
      particularly of the fast-dividing nonmuscle cells. This inhibition might be a
      contributory factor to cardiomyopathy, but it does not explain the cessation of
      the rhythmic contractions characteristic of myocardial cells in culture. The
      concentrations of ATP and phosphorylcreatine (PC) were decreased in the
      adriamycin-treated cells, but the addition of creatine resulted in a several-fold
      increase of PC. Therefore, the regulation of energy production and the potential
      to maintain a high, steady-state concentration of PC were not impaired.

PMID- 1032028
TI  - Fine structure of the sinoatrial node of rabbit heart.

PMID- 1032029
TI  - Fine structure of the conduction system and working myocardium in the little
      brown bat, Myotis lucifugus.
AB  - In the little brown bat, Myotis lucifugus, topography and ultrastructure of the
      sinus node and the atrioventricular (AV) node resemble those in large mammalian
      hearts, except that the P cells in the sinus node are smaller than those in the
      bat AV node or those in the sinus node of slower hearts (e.g., dog, man). Despite
      rich innervation in the bat nodes, true neuromuscular synapses are rarely formed.
      Bat working cardiocytes have a well developed sarcoplasmic reticulum, but
      otherwise resemble working myocytes of larger mammals.

PMID- 1032030
TI  - Fucosidosis: diagnosis of five patients and carrier detection.
AB  - The clinical and biochemical data of the two original cases of fucosidosis type I
      and of three other type II are reported. Of less than forty patients affected
      with fucosidosis, described in the literature, seven belong to two pedigree
      originating from a small, isolated area of the Southern Italian region of
      Calabria. All the affected children were born from first cousin marriages.
      Clinical heterogeneity has been observed inside both pedigrees and some patients
      show angiokeratoma while others do not.

PMID- 1032031
TI  - Fucosidosis: a neuropathological study.
AB  - The involvement of the central nervous system in fucosidosis is related to severe
      lesions of both nerve and glial cells. The morphology of cells degeneration is
      characterized by both vacuoli containing water-soluble fuco-derivatives (fuco
      oligosaccharides) and/or granular substances probably constituted by fuco
      sphingolipds. The cerebral cortex is the most severely affected. The involvement
      of the white matter is related to the glial cells degeneration. The relationship
      between the morphology of nerve and glial cells lesions, and the accumulation of
      oligosaccharides and sphingolipids following the absence of alpha-L-fucosidase,
      is briefly discussed.

PMID- 1032032
TI  - [Familial myotonic syndrome with hyposthenia corrected with exercise (author's
      transl)].
AB  - In some cases of myotonic syndromes a paresis after rest has been described
      corrected by exercise. This syndrome is reported in two brothers. In myotonic
      patients repetitive stimulation of a nerve causes a transitory decrease of the
      muscle action potential. Probably the paresis corrected by exercise only
      represents the clinical evidence of the electrophysiological phenomenon mentioned
      above. This seems to be a common occurrence and therefore does not represent a
      new nosologic entity.

PMID- 1032033
TI  - The syndrome of carnitine deficiency.
AB  - Three cases of lipid storage myopathy and carnitine deficiency are presented. Two
      had a fatal course and were insensitive to cortisone and carnitine-replacement
      therapy. The two fatal cases had lipid accumulation in organs other than the
      skeletal muscles and carnitine was reduced in plasma, skeletal muscles, heart and
      liver. Fibroblasts from one of these "generalized" cases of carnitine deficiency
      were grown from a skin biopsy. Carnitine level, fatty acids uptake and oxidation
      were not appreciably different between the patients' fibroblasts and those of
      controls.

PMID- 1032034
TI  - The neurophysiological features of various diseases with NCL storage.
AB  - Combined EEG/ERG/VER studies were carried out on 47 children with verified
      neuronal storage of ceroid/lipofuscin-like material. The majority of patients
      fell into one of three main groups. Each group showed its own characteristic
      combination of neurophysiological features which were of diagnostic importance
      and closely parallel to the age of onset and the evolution of clinical symptoms
      characteristic to each group. These findings suggest that general terms such as
      "NCL" or "Batten's disease" imply a single disease process and are misleading.

PMID- 1032035
TI  - Recent findings on some "new" neurometabolic diseases.
AB  - The most common inborn error of glycoprotein catabolism appears to be
      aspartylglycosaminuria (AGU). It is characterized by deepening mental
      retardation, progressive lesions of connective tissue, and increased urinary
      excretion of aspartyglycosylamine. The first symptoms usually appear after 3
      years of age and closely resemble those of Hurler's disease. The condition is a
      hereditary lysosomal storage disease due to a defective enzyme. The main clinical
      findings in a infantile type of neuronal ceroid-lipofuscinosis (INCL) are
      psychomotor retardation, visual failure, and a virtually isoelectric E.E.G. at
      the final stage of the disease. The symptoms of this hereditary disorder first
      appear between 8 and 18 months of age and the mean age at death is 6.5 years.
      Striking cerebral and cerebellar atrophy, together with neuronal loss and
      accumulation of lipofuscin-like material, can be observed at neuropathological
      examination.

PMID- 1032036
TI  - Studies on the clustering of multiple sclerosis in Finland.
AB  - The epidemiological investigation of multiple sclerosis (MS) in Finland revealed
      a prevalence rate of 40.3 per 100.000 inhabitants. The geographic distribution of
      MS was uneven in the country. MS seemed to occur more often in the western and
      southwestern parts of the country, where the prevalences varied between 51.7 and
      62.1 This phenomenon became even more pronounced when the distribution of the
      disease was investigated in small geographic units. Optic neuritis showed a
      geographic distribution similar to that of MS, with clustering in the same parts
      of the country and even in the same narrow districts. The correlation between the
      birthplaces of MS and optic neuritis patients was very significant (p less than
      0.001), which suggest that they share a common aetiology. The possible
      aetiological role of genetic and exogenous factors was discussed in the western
      cluster of MS, where the percentage of familial cases was 13 and an accumulation
      of muscular dystrophy of cattle was observed.

PMID- 1032037
TI  - Epidemiological survey on multiple sclerosis in Italy.
AB  - An epidemiological survey on Multiple Sclerosis was carried out in 1975 with
      similar methods in 9 italian provinces: 4 in the North, 2 in central Italy and 3
      in the south and islands. It was found that the incidence of the disease was
      partically uniform in the northern provinces, in the central Italy and in Bari
      province. It is important however to complete in greater detail such survey in
      the south of Italy where the data are still incomplete.

PMID- 1032038
TI  - [A case of visual agnosia for objects (author's transl)].
AB  - Following an ischemic accident in the territory of the left posterior cerebral
      artery, a 71 year-old woman had a severe disorder of visual recognition of
      objects while she quickly identified them by touch. Visual recognition of
      pictures, written symbols, colours and, to a lesser degree, faces was also
      impaired. A careful examination showed that the patient's defect could not be
      accounted for by general intellectual impairment, language disorder, visual
      acuity, or pattern discrimination deficit. These findings are consistent with the
      classical concept of associative agnosia: the pathophysiology of the syndrome is
      discussed.

PMID- 1032039
TI  - [The Rorschach test during chronic haemodialysis (author's transl)].
AB  - Twenty-eight patients undergoing chronic haemodialysis for renal failure and
      seven patients suffering from chronic uremia, but not on dialysis programs were
      submitted to the Rorschach test. The patients who were undergoing haemodialysis
      for less than one year showed higher signs of anxiety (shock and Hd responses);
      on the other hand patients undergoing the treatment for more than 5 years showed
      a generally worse quality response to the test. This bad performance was
      interpreted either as a sign of organic brain damage or as a worse cooperation in
      the test procedure.

PMID- 1032040
TI  - Hobson's choice.

PMID- 1032041
TI  - Prognosis in arteriosclerotic heart disease.

PMID- 1032042
TI  - Cardiovascular physiology of dynamic and static exercise.

PMID- 1032044
TI  - The art of caring.

PMID- 1032043
TI  - Stress electrocardiogram--probabilities of disease.

PMID- 1032045
TI  - The family system and physical illness.

PMID- 1032046
TI  - Pathophysiology and diagnosis of diabetes mellitus.

PMID- 1032047
TI  - Unusual electrocardiograms in athletes.

PMID- 1032048
TI  - [Space requiring intracranial conditions and pregnancy].
AB  - Gravidity and the intracranial process are discussed in view of the question of
      whether to carry out an interruption of pregnancy or to carry the pregnancy to
      full term and end it by means of Cesarean section, on the basis of literature and
      5 observations.--It is recommended to work out an individual plan of treatment
      together with the obstetrician and the neurologist. It was shown that there is a
      possibility of an operative treatment of intracranial processes of different
      genesis even in the advanced stage of pregnancy and with the continuation
      pregnancy.

PMID- 1032049
TI  - [Qualitative function test of ventriculo-atrial drainage using Cordis-Hakim
      valves].
AB  - Description of the acoustic detection of the functional performance of Cordis
      Hakim valves. This can be monitored or perceived with a surface microphone, or
      demonstrated by means of an oscilloscope. To document the findings the image of
      the viewing screen can be photographed or continuously registered through
      interconnection of a recorder. There is also the possibility of testing with the
      stethoscope. The construction of the device and experimental arrangements are
      described.

PMID- 1032050
TI  - [Reperfusion following cerebrovascular arrest].
AB  - An account is given of a case of artificial perfusion of isolated organ after
      operative correction of an angiographically recorded standstill of the
      circulatory system. Criteria of cerebral death and determination of the time of
      death are discussed.

PMID- 1032051
TI  - Studies on cartilage formation XIX. Oxygen and glucose supply of the regenerating
      articular surface.
AB  - Complete removal of the articular cartilage in dogs is followed by regeneration
      of the articular surface. At the site of the bone wound, granulation tissue
      develops, which later differentiates into cartilage. The O2 and glucose supply of
      the regenerating articular surface is ensured by the synovial fluid, by the large
      exposed surface of the medullary cavity, and by the capillary network of the
      granulation tissue. Oxygen and glucose supply of the articular surface in
      different stages of differentiation has been statistically analyzed. It is
      suggested that in the early stage of regeneration O2 supply comes predominantly
      from the capillaries of the granulation tissue. Later on, as capillarization
      regresses, the oxygen supply, originating from the synovia and medullary cavity,
      assumes a more important role. In the stage of cartilage regeneration an oxygen
      deficient state can be supposed in the entire articular surface, but areas
      differing in oxygen supply may be formed owing to local differences (due mainly
      to the extent of vascularization and degree of generation of the subchondral bone
      layer). At the site of chondrogenesis, conditions allowing aerobic metabolism of
      cells with reduced O2 requirements seem to be ensured. Glucose supply deriving
      from the above-mentioned sources satisfies the highest glucose requirements of
      the cells in the regenerating articular surface.

PMID- 1032052
TI  - The development of the ipsilateral retinothalamic projections in the Xenopus
      toad.
AB  - The appearance of ipsilateral terminal degeneration in the thalamic visual
      centers is studied with the aid of the Fink-Heimer II technique in Xenopus larvae
      and postmetamorphic toadlets following unilateral eye removal. The youngest age
      at which degeneration can reliably be shown in the lateral geniculate complex
      (nucleus of Bellonci and corpus geniculatum thalami) was at stage 62, that is, 10
      12 days before metamorphic climax. The whole compliment of the ipsilateral
      retinothalamic projection develops only in postmetamorphic toadlets, and it is
      much more abundant in Xenopus than in Rana species. The first appearance of the
      ipsilateral degeneration in the lateral geniculate complex coincides in time with
      the first ipsilateral visuotectal responses described by others. The possibility
      that the two phenomena may have  a closer relationship than the mere time
      coincidence, is discussed.

PMID- 1032053
TI  - Morphology of the post-ovulatory follicle of house sparrow.
AB  - The morphology of the post-ovulatory follicle (or corpus luteum) in the sparrow
      (Passer domesticus) ovary has been investigated with special reference to the
      origin of luteal cells which finally fill the fillicular activity. The
      development and degeneration of luteal cell mass has been described in three
      phases. The luteal cell mass consists of hypertrophied granulosa luteal cells
      during the first phase and of both granulosa and thecal luteal cells during the
      second phase. During the second phase owing to their different staining
      reactions, both types of luteal cells can be differentiated. In the advanced
      stages of regression, i.e. during the third phase, the whole luteal cell mass
      consists of thecal luteal cells and connective tissue elements as the granulosa
      luteal cells had degenerated and disappeared by this stage.

PMID- 1032054
TI  - Role of ultimobranchial body and corpuscle of Stannius in regulation of the
      plasma calcium and phosphorus levels in the teleost Heteropneustes fossilis.
AB  - Effects of NaF, CaCl2, NaCl and mammalian calcitonin on the histology of ultimo
      branchial (UTB) and corpuscle of Stannius (CS) and plasma levels of calcium and
      phosphorus in the teleost Heteropneustes fossilis are recorded. Administration of
      NaF, NaCl, and mammalian calcitonin resulted in varying degree of hypolcalcaemia
      and hyperphosphataemia, whereas hypercalcaemia and hypophosphataemia developed
      during CaCl2 treatment. These treatments also produced various histological
      changes in UTB and CS. It is suggested that CS and UTB are involved in
      metabolisms of Ca and P, and in osmoregulation. Moreover, it is an important
      hypocalcaemic mechanism in this fish in combating hypercalcaemia.

PMID- 1032055
TI  - Dry weight and 5HT concentration in the cerebral ganglia of Anodonta (Mollusca)
      during activity.
AB  - As shown by interferometry, the amount of protein in neuron bodies of Anodonta
      cygnea L. cerebral ganglia changed in direct relation to the duration of the
      active state of the mollusc. The amount of serotonin in cerebral ganglia changes
      independently of the amount of protein in nerve cells, although it varies
      consistently with the activity and rest of the animal.

PMID- 1032056
TI  - Rosette formation of concanavalin A-treated erythrocytes around polymorphonuclear
      leucocytes and lymphocytes.
AB  - Concanavalin A (Con A) induces rosette formation of erythrocytes around
      polymorphonuclear leucocytes and lymphocytes in cell suspensions of autologous
      human blood cells. The effect which is most characteristic in a concentration
      between 25 and 50 microgram/ml is due to Con A bound on the erythrocyte membrane.
      A similar effect, although less pronounced, was observed with phytohaemagglutinin
      at concentrations of 10 and 25 microgram/ml. The treated erythrocytes showed a
      higher affinity to polymorphonuclears when compared with lymphocytes. At the
      contact area, the membrane of the erythrocyte became highly folded while its free
      surface was smooth and spherical. The effect of the local concentration and
      immunobilization of the lectin on the erythrocyte membrane and the similarity of
      the contact pattern to that of erythrophagocytosis are discussed.

PMID- 1032057
TI  - Axonal labyrinths in the rat spinal cord: a consequence of degenerative atrophy.
AB  - Transection, crush or local colchicine treatment of a peripheral nerve induces
      degenerative atrophy of central terminals of primary sensory neurons in the
      Rolando substance of the rat spinal cord. In addition to osmiophilic alterations
      that occur in the course of degenerative processes in general, degenerative
      atrophy is characterized by the appearance of spectacular labyrinthine
      formations. Electron-microscopic analysis reveals that these consist of flattened
      axonal profiles. Axonal labyrinths are interpreted as signs of futile
      regenerative efforts of axon terminals undergoining degenerative atrophy.
      Labyrinths disappear from the Rolando substance several months after peripheral
      nerve injury, when degenerative atrophy of the central terminal is replaced by
      regenerative proliferation.

PMID- 1032058
TI  - Oestradiol uptake by intact and sympathectomized genital tract of the female
      rabbit.

PMID- 1032059
TI  - Heterogeneity in the fibres of the body wall muscles of the earthworm.

PMID- 1032060
TI  - A comparison of Mersilene and polyglycolic acid sutures in pararectal abdominal
      wounds after appendectomy.
AB  - A total of 206 patients were subjected to operation for acute appendicitis
      through a pararectal laparotomy. Mersilene was used in 101 and polyglycolic acid
      (PGA, Dexon) in 105 patients as buried sutures for the closure of the abdominal
      wall, including the fascial layer. Wound complications developed after Mersilene
      in 23 and after PGA in 10 cases. PGA did not lead to an increased frequency of
      early wound infections. Granulomata or fistulae developed after Mersilene in 18
      patients, but not in any of the cases in which PGA was used. Wound rupture and
      incisional hernia did not occur in any of the patients in the two groups.

PMID- 1032061
TI  - Ventilation efficiency after different incisions for cholecystectomy.
AB  - Forced expiratory vital capacity (VC), forced expired volume during the 1st
      second (FEV1) and peak expiratory flow (PEF) were measured preoperatively and
      during the first four postoperative days in 44 patients undergoing
      cholecystectomy. 18 patients had a muscle splitting incision (M.S.), with no
      transection of the abdominal muscles; 15 patients had a subcostal incision with
      transection of the rectus muscle; 11 patients had a midline incision with
      transection of linea alba. Postoperatively, VC and FEV1 were reduced to 75% of
      the preoperative value with a m.s. incision, and to 40-55% with a subcostal or
      midline incision PEF was reduced to 65% of the initial value with a m.s. incision
      and to 50% with the other incisions. Almost every second patient with a m.s.
      incision had returned to the initial VC and PEF within four days, whereas only
      one did so with a subcostal or mid-line incision. In conclusion, the m.s.
      incision reduces postoperative ventilation efficiency less than other incisions.
      Its use may reduce postoperative pulmonary complications and shorten the hospital
      stay.

PMID- 1032062
TI  - Preoperative localization of nonpalpable breast tumours.
AB  - A simple method for the preoperative localization of nonpalpable breast tumours
      detected by mammography is described. A small amount of a mixture of contrast
      media and visible dye is injected into the breast precisely ventral to the lesion
      and the site of injection is marked on the skin. Forty patients have been
      operated upon and all the tumours were found without difficulty.

PMID- 1032063
TI  - Popliteal vessel injury.
AB  - Popliteal vessel injury still carries a high amputation rate despite the
      progresses which have been made in vascular surgery. Three patients with such
      injuries treated with vascular repair are reported and a review of the recent
      literature is given. Prognostic factors as early diagnosis, delay in treatment,
      associated injuries as fracture/dislocation and venous injury, soft tissue
      injuries, adequate vascular repair, and postoperative complications are
      discussed.

PMID- 1032064
TI  - Temporary arterio-venous shunts to dilate saphenous crossover graft and maintain
      graft patency.
AB  - A modification of the Palma operation is described in a 25-year-old man with
      impaired venous outflow of the right leg. After a phlebitic occlusion of the
      right superficial femoral and external iliac veins he had been operated on twice
      for varicose veins. The result of these operations was a serious outflow stasis
      of the right leg during exercise. A saphenous cross-over graft to the right
      popliteal vein was constructed. Preoperatively a temporary arterio-venous shunt
      between the left posterior tibial artery and the great saphenous vein had been
      made in order to increase the diameter of the saphenous vein. Three months later
      the dilated saphenous vein was resected at the level of the sapheno-tibial artery
      shunt and anastomosed to the popliteal vein of the right leg. The cross-over
      graft occluded several times during this operation. A temporary popliteo
      popliteal arterio-venous shunt was established distally to the sapheno-popliteal
      anastomosis to keep the vein graft patent. This second arterio-venous shunt was
      resected after three months. Venography one month later showed that the vein
      graft was patent. The patient's complaints had disappeared one month after the
      operation and a normalization of his venous outflow was recorded
      plethysmographically. The graft has remained patent during an observation time of
      eighteen months.

PMID- 1032065
TI  - Abdominal stab wounds.
AB  - The records of 57 patients with abdominal stab wounds, treated at the Surgical
      Departments of the Sahlgrenska Hospital, Goteborg, between 1969-1974, were
      revised. Fifty-five patients were males and 2 females. The wounds were situated
      in the upper abdomen in 72% of the patients. Forty-nine patients were treated
      with an explorative laparotomy and the findings were considered to be negative in
      31% of these patients. Liver injuries were found in 45% of the operated patients.
      No complications occurred in the patients with negative laparotomy findings. One
      patient with multiple intra-abdominal lesions succumbed from an irreversible
      septic shock.

PMID- 1032066
TI  - Non-occlusive enteric gangrene associated with severe upper gastrointestinal
      bleeding.
AB  - Six cases of non-occlusive enteric gangrene in association with severe upper
      gastro-intestinal haemorrhage are described, the incidence of which corresponds
      to approximately one per cent of the patients with serious gastric bleedings. A
      brief discussion of the pathophysiology of ischaemic gut lesions is given. In
      order to reduce the incidence of this disease rapid and adequate treatment of all
      massive gastro-intestinal bleedings is emphasized. Patients with unexplained
      abdominal pain in association with haemorrhagic shock should especially be
      regarded as being at risk of developing the enteric gangrene.

PMID- 1032067
TI  - Gastric acid secretion in patients with prepyloric ulcer and with combined
      gastric and duodenal ulcer.
AB  - The gastric acid secretion during stimulation with histamine given via a
      continuous intravenous infusion (i.e. during steady state conditions) was studied
      in 13 patients with prepyloric ulcers and in 21 patients with combined gastric
      and duodenal ulcers. The rate of volume secretion, the acidity and the acid
      output were analysed separately. The results were compared with earlier studies
      of patients with gastric ulcer and duodenal ulcer. Starting from the secretory
      pattern these four groups of ulcer were characterized. Gastric ulcers thus show
      hypoacidity. The pyloric ulcers do not differ from a normal material. The
      combined gastric and duodenal ulcers and the duodenal ulcers show hypersecretion,
      most pronounced in duodenal ulcers.

PMID- 1032068
TI  - Pyogenic liver abscess as a cause of acute upper abdominal pain. A report of two
      cases.
AB  - The clinical course of 2 patients with acute abdominal pain, which was eventually
      found to be due to pyogenic hepatic abscesses is described. One patient, operated
      on late in the course, died; the other, who was operated on early, recovered. The
      importance of considering this life-threatening disease in the differential
      diagnosis of acute abdominal pain is emphasized.

PMID- 1032069
TI  - Neurolept anesthesia: balanced or unbalanced?

PMID- 1032070
TI  - A double blind comparison of buprenorphine and morphine in conscious subjects
      following administration by the intramuscular route.
AB  - Buprenorphine was studied to determine the respiratory depressant effect in a
      double blind comparison with morphine. Buprenorphine produced a more prolonged
      displacement of the carbon dioxide response curve than morphine. Because of the
      marked difference in the time effect curves the relative potency was determined
      at the time of peak effect--3 hours post-administration for buprenorphine (0.15
      and 0.3 mg) and 1 hour post administration for morphine (5 and 10 mg). The data
      from the subjects who received higher doses of buprenorphine (0.6 and 1.2 mg)
      showed that there was a linear relationship over the dose range 0.15-1.2 mg in
      terms of respiratory depression.

PMID- 1032071
TI  - Muscle relaxants: the classical receptor theory.
AB  - According to the classical receptor occupancy theory non-depolarizing and
      depolarizing muscle relaxants differ in one respect: both types of drugs possess
      affinity for the cholinergic receptor at the neuro-muscular function, but only
      the depolarizing relaxants show efficacy. The two properties, affinity and
      efficacy are independent from each other.

PMID- 1032072
TI  - Affinity concept and the action of the muscle relaxants.

PMID- 1032073
TI  - Endocrine control of postcranial body proportions. An experimental study of
      allometry.

PMID- 1032074
TI  - Internal surface and fine structure of the rat seminal vesicle.
AB  - The seminal vesicle of the rat was studied with scanning and transmission
      electron microscopy. The internal surface of the organ is partitioned into small
      areas by a system of elevated ridges of connective tissue and covered by a
      columnar epithelium. This consists of small basal cells, presumably reserve
      elements, and larger ones containing the typical cell organelles involved in
      protein synthesis. The surface of the cell is covered with slender microvilli,
      varying in height and number from region to region. It is suggested that they are
      involved in the maintenance of hydration and/or regulation of low molecular
      weight substances in the secretion product. The latter develops from small
      granules which pass the apical cell border and then fuse together as larger
      drops.

PMID- 1032075
TI  - Arterial vascularization of the sinuatrial node in the embryonic rat heart.
AB  - We studied the embryological development of the extracoronary cardiac vessels,
      determining their origins, courses and terminations in embryonic rat hearts. The
      sinuatrial node is supplied by an extracoronary artery, which can originate from
      (a) the right internal mammary artery, as a nodal artery, based on its origin;
      (b) the internal mammary artery, or (c) the right subclavian artery as a
      collateral artery of the cardiac branch of the cardiomediastinal trunk. The
      intimate relations of the nodal artery with the sinus node make it possible to
      study, at the same time, the development of the sinuatrial node in the rat
      embryo. The sinuatrial node always develops before the nodal artery, which does
      not appear until 16 or 16.5 days of development.

PMID- 1032076
TI  - Biology of the rice rat (Oryzomys palustris natator) in a laborabory environment.
      X. Postweaning growth of the skull.
AB  - A survey of skull development of the rice rat (Oryzomys palustris natator)
      covering a period of 21 days to 16 months involving equal numbers of males and
      females (108) was undertaken using various skull parameters. Sexual dimorphism in
      relation to body weight and length emerged before that of the skull which was
      only clearly marked by 2 months. A number of the skull parameters by virtue of
      their individual growth potential did not show sexual differences in size for a
      long time, whereas others were clearly marked. Once the differences between the
      sexes had been established they were maintained. One parameter - lenght of
      cranium - represents those parameters which show changes and it was found that
      the male rat continued to show a steady linear increase in length up to 16
      months, whereas the female cranial length shows a deceleration with termination
      around 12 months. The skull differences are mirrored in the weight and length
      findings and it suggested that the earlier sexual maturity of the females is
      compensated by an earlier cessation of growth compared to the males which mature
      later and have a correspondingly later cessation.

PMID- 1032077
TI  - Ultrastructural study on topographical variations of the ependyma in Bradypus
      tridactylus.
AB  - An electron-microscopic study of ependymal cells in 24 different areas of the
      encephalic ventricular system of Bradypus tridactylus was made, with a view to
      making a comparative analysis, of a topographical kind, of various cell
      components: cilia, microvilli, plasma membrane, cytoplasmic protrusions, types of
      cellular junctions, ribosomes, Golgi apparatus, endoplasmic reticulum,
      microfilaments, microtubules, mitochondria, granules and dense bodies. There were
      differences in the distribution of all these cytologic elements, according to the
      topography, being a complement to a similar work done by the same authors with
      light-microscopy. By means of a morphofunctional analysis they draw the
      conclusion that even if one can admit the passage of substances by an
      intracellular route, on the other hand few facts support the idea the
      intracellular absorption or secretion could be considered as important phenomena
      in a great number of the ependymal areas studied.

PMID- 1032078
TI  - [Peculiarities of myelin formation in the spinal roots of the rabbit].
AB  - The axon sheath formation in the ventral and dorsal spinal roots of newborn
      rabbits is discussed. The mesaxon grows at a greater rate than the outer
      plasmalemma of the Schwann cell, thereby giving rise to folds in the mesaxon. The
      compact myelin spiral is formed by the apposition of 2-3 lamellae.

PMID- 1032079
TI  - Possible phylogenetical significance of the corpus callosum with special
      reference to the dolphin brain (Stenella graffmani).
AB  - The surface area of the corpus callosum was measured in several animals as
      compared to the brain weight. A general consideration of the importance of this
      structure on the phylogenetic scale, with special reference to the corpus
      callosum of the dolphin, Stenella graffmani, is given. Some theoretical
      considerations about the significance of this structure upon some specialized
      features are mentioned.

PMID- 1032080
TI  - Hypothalamic neurosecretory system of the spotted owlet, Athene brama Temminck.

PMID- 1032081
TI  - Further observations on the ear in fossorial mammals with special considerations
      of Chlamyphorus truncatus (Harlan).
AB  - The morphology of the external and the middle ear (auditory ossicles) in
      Chlamyphorus truncatus is influenced by its fossorial life. The external auditory
      canal consists of three parts. The most distal part is a short (cartilaginous)
      auricle which reaches anteriorly close behing the eye. Posteriorly to the auricle
      is a long, thin bony duct which consists of two segments, movable against each
      other. This tube leads through a narrow porus into the third part of the canal,
      the recessus meatus, which is enclosed in the bulla. The recessus with the narrow
      porus is characteristic for many fossorials and has a morphology with physical
      chracteristics of a resonator (HELMOHOLTZ). The malleus and the stapes in Ch.
      truncatus are also influenced by fossorial life. Based on the dorsal view of the
      malleus head, the Xenarthra can be divided into two groups. To the first division
      belong the Dasypodidae with Chlamyphorinae and Dasypodinae, to the second the
      Myrmecophagidae and Bradypodidae. The malleus of Cyclopes, a myrmecophagid,
      differs from that in the other Mymecophaginae and is similar to the malleus in
      the Dasypodinae. Two kinds of experiments should be undertaken: (a) physiologic
      acoustic experiments in a fossorial to determine the effect of the recesses and
      (b) acoustic experiments varying the dimensions and positions of a tube and a
      porus leading into a resonator.

PMID- 1032082
TI  - Anteversion versus torsion of the femoral neck.
AB  - The usual term 'torsion angle of the femur' denotes the 'anteversion' of the neck
      of the femur as a whole, caused by the twist in the shaft of the femur rather
      than the twist in the neck. This has been differentiated from the twist in the
      neck of the femur around its own axis, termed 'torsion neck' and the values of
      both have been measured. To differentiate these two different phenomena, the term
      'anteversion' is used to denote the usual angel described, while 'torsion neck'
      is sued to denote the twist in the neck around its own axis measured in this
      work. 1,000 femora from 21 cites in different parts of the country have been
      measured and the average anteversion angle calculated. The Indian average works
      out to be 12 degrees with a significantly (double) high value for females. The
      incidence of negative angle is 7% in the normal femora. All fractured femora
      invariably show a negative angle. The above information should be of great
      significance on orthopaedic surgery of the neck of the femur in these bones. The
      'torsion neck' has been measured by tracing and its average reported as 30
      degrees.

PMID- 1032083
TI  - Alkaline phosphatase in the thymus.
AB  - (1) Fetal thymuses, organs from patients who died from diseases that are not
      clinically known to be associated with concomitant lymphoid tissue involvement,
      as well as thymuses from patients dying from diseases which effect the lymphatic
      complex of the body, one way or another, have been investigated for their
      alkaline phosphatase activity, using Gomori technique and applying four different
      phosphate esters as substrates. (2) Three substrates (beta-glycerophophate,
      riboflavin 5-phosphate and adenosine triphosphate) showed essentially the same
      pattern of activity in which the cortex and Hassall's corpuscles were reactive,
      while the medulla was negative. A reversal of this pattern was demonstrated with
      5-monophosphoric acid. (3) Before the age of 32-36 weeks of intra-uterine life
      there is no alkaline phosphatase activity in the thymus; therafter, the enzyme
      begins to make its first appearance. (4) There is a definite increase in the
      intensity of the reaction with advance of intra-uterine life. This increase in
      phosphatase content is continued postnatally, to reach its maximum at about the
      age of 10 years: after that, the enzyme activity gradually subsides. (5) There is
      a tremendous augmentation of phosphatase activity in the case of disease which
      are known to affect the lymphoid complex. (6) The phosphatase activity of the
      thymus has been discussed in relation to the prevailing concepts about the
      function of the thymus, with special emphasis on a possible association with
      'lymphocyte-stimulating factor' production and/or secretion.

PMID- 1032084
TI  - Some ultrastructural observations on human palmar stratum corneum.
AB  - Ultrastructure of human palmar stratum corneum was examined for cell junctions
      and cytoplasmic material. Interdigitated microvilli are shorter and less uniform
      in man. Most of these processes are either conical or truncated in shape, as
      distinct from the relatively smooth cell surfaces except for sigma-shaped
      junctions in hairy sites. It is suggested that this provides strength against
      shearing force in the palm and sole. There is less cytoplasmic breakdown in
      palmar horny cells than in hairy cells.

PMID- 1032085
TI  - Effect of cortisol and insulin on alpha1-acid glycoprotein biosynthesis on
      cellular level.

PMID- 1032086
TI  - The role of cortisol and insulin in control of alpha1-acid glycoprotein
      biosynthesis.

PMID- 1032087
TI  - Serum isoenzymes of the lactic acid dehydrogenase, carboxylesterase, peroxidase
      and catalase in the thyroid disease with respect to thyroid cancer.

PMID- 1032088
TI  - Radiation--induced damages of the heart and major arteries.

PMID- 1032089
TI  - Hydatid cyst originating from ampulla of Vater.

PMID- 1032090
TI  - Growth of the chick embryo pineal body (epiphysis cerebri) between the fourth and
      twelfth day of incubation.

PMID- 1032091
TI  - Some applications of the theory of ordinary differential equations to population
      growth problems.

PMID- 1032092
TI  - [Studies on urease from the seeds of Citrullus vulgaris: action of chemical
      agents and ionizing radiations].
AB  - Urease obtained from seeds of Citrullus vulgaris fruits has been studied under
      three points of view: a) the effect of the urea analogs acetamide and hydroxi
      urea on the enzyme kinetic b) the action of the sulfhydryl reagents and the
      reactivation agents on the enzyme c) the effect of X-rays and the protective
      action of the cysteamine. The Berthelot reaction for the determination of the
      liberated NH3 was used enzyme activity. Acetamide has no effect on urease
      kinetic. Hidroxy-urea which produces a typical green color when it is mixed with
      the Berthelot reagents at high concentrations, when properly diluted acts a
      aompetitive inhibitor of urease. Spectrophotometric experiments suggest that the
      studied urease decomposes hydroxi-urea with liberation of hydroxilamine. The
      sulphydril reagent, p-hydroxi-mercuribenzoate inhibits the enzime. Cysteine and
      dithiotreitol reactivate the enzyme activity in no more then 50% even when excess
      of the substances is used. Probably only in the first step of the urea
      hydrolysis, the enzyme behaves as a typical SH-enzyme. Urease is very sensitive
      to X-rays. Cysteamine acts as a protective agent of the enzyme. Dithiotreitol
      reinforces this protective action. This effect is clearly observed when the
      Fisbein catalytic method for urease is employed.

PMID- 1032093
TI  - Isolation and some properties of a trypsin inhibitor from seeds of Schizolobium
      parahyba (Vell.) Toledo.
AB  - A trypsin inhibitor was isolated as a homogenous protein from the seeds of
      guapuruvu-tree (Schizolobium parahyba (Vell.) Toledo). In addition to its strong
      inhibitory activity against trypsin the purified inhibitor presented a lesser
      activity against alpha-chymotrypsin. The purification of the protein inhibitor
      was achieved from the crude extract of deffated seeds through ammonium sulphate
      salting-out, successive chromatographies on Sephadex G-75 and DEAE-Sephadex A-50
      columns followed by preparative polyacrylamide-slab electrophoresis. The
      following properties were presented by the purified inhibitor: molecular weight
      of 12,000 daltons, as estimated by gel filtration; isoelectric point at pH 5.0 -
      5.2, by electrofocusing; combining molar ratio of 1:1 (mole trypsin/mole
      inhibitor), on the basis of inhibition assay and the molecular weight of 29,800
      daltons found for the trypsin-inhibitor complex; A1%1-cm = 4.35, at 275 nm and pH
      7.0. The inhibitor presents a high content of cystine (14 cystinyl residues per
      molecule) and is entirely devoid of methionine, tryptophan and free sulhydryl
      groups. The fluorescence spectra are typical for tyrosine with a strong quenching
      of emission indicated by the quantum yield. The circular dichroism spectra
      suggest a predominantly unordered structure for the inhibitor molecule.

PMID- 1032094
TI  - The chemistry of the inhibition of blood xanthine oxidase by -SH reagents.
AB  - In this study it was shown that the rat blood serum xanthine oxidase (X.O.) is
      differently inhibited by -SH reagents and seems that the blood serum enzyme has
      two types of -SH groups, one reacting relatively rapidly and unrelated to the
      enzyme activity and the other reacting slowly to produce inactivation. The
      results presented suggest that there are only few fundamental relationship
      between the different -SH reagents used and the inhibition of the enzyme activity
      in the blood serum. With mercurials it was shown that the most reactive -SH
      groups of the rat blood serum are not related to the X.O. activity, but when
      sufficient number are reacted the enzyme is structurally altered so that
      inhibition appears. With oxidants such as iodine the inhibition of the X.O.
      activity of rat blood serum seems to be not related specifically with the
      oxidation of -SH groups.

PMID- 1032095
TI  - The world food crisis: population, food, and environmental issues as they affect
      Pakistan.

PMID- 1032096
TI  - Norin-10-based semidwarfism.
AB  - Many short-strawed wheats, including the Norin-10-based semidwarfs now grown in
      many countries, are characterized by their relative "insensitivity" to
      gibberellic acid. The nature of this insensitivity, its genetic control, and the
      relationships between the Gai genes and the Rht genes, which control height
      reductiion in Norin-10 and Tom Thumb wheats, are described. The role and
      potential of these genes in agriculture and their relationship to other genes
      affecting yield, height, and other agronomic features are considered.

PMID- 1032097
TI  - Evaluation of branched ear derivatives of Triticum aestivum L.
AB  - The branched spikes of Triticum turgidum L. have a potential of producing a high
      number of kernels. Some of the selected lines of T. turgidum yielded up to 150
      kernels per spike as compared to 60--70 kernels per spike in the common wheat
      cultivar Chenab-70. The best of these lines were crossed with the common wheats
      Chenab-70, Mexipak, and C-271. Among the lines obtained by selection from the
      advanced generations of the T. turgidum X Chenab-70 cross, some are similar to
      Chenab-70 with respect to tillering, plant shape, plant height, and leaf
      position, but their spikes are branched like those of the T. turgidum parent.
      These lines appear to be fairly homozygous. Chenab-70 produces, on the average,
      60 kernels per spike, 34.8 g of grain per plant and has a 1000-kernel weight of
      35 g. The number of kernels per spike, the yield of grain per plant and the 1000
      kernel weight of the selected hybrid lines ranged from 25 to 133, from 8.5 to
      59.6 g, and from 30.0 to 46.0 g, respectively, which shows that the chances of
      obtaining high-yielding new common wheat cultivars having spikes branched as
      those of the T. turgidum parent fairly good.

PMID- 1032098
TI  - Principal diseases of major crops in Pakistan with reference to genetic
      resistance.

PMID- 1032099
TI  - The measurement of disease severity in cereal smut.

PMID- 1032100
TI  - Stabilizing selection for pathogenicity in cereal rust fungi.

PMID- 1032101
TI  - Coadaptation in plant populations.
AB  - One of the most important questions of plant breeding is whether alleles at
      different loci act independently or whether the population genotype is structured
      so that favored combinations of alleles occur more frequently than expected under
      randomness. Studies employing allozyme loci as markers have demonstrated that the
      distribution of alleles in both natural and experimental populations of
      inbreeding plants is closely correlated with environment on both micro- and
      macrogeographic scales. Multilocus analyses have also revealed the occurrence
      within local populations of striking gametic phase disequilibrium (linkage
      disequilibrium). These observations demonstrate that selection acts to organize
      the population into sets of highly interacting coadapted gene complexes that
      promote high fitness to the local environment.

PMID- 1032102
TI  - Estimation of genotypic and environmental variation in plants.
AB  - The frequency of genotypes with the desired degree of expression of economically
      important quantitative characters within a hybrid or mutant population is usually
      very low. Therefore, the early identification and selection of such genotypes
      involves the analysis of very large populations. Because the breeding values of
      individuals in a population are masked by environmental, competitional, and
      ontogenic noises, special quantitative--genetic methods of analysis have to be
      used in order to eliminate their disturbing effects. The present chapter deals
      with a new approach to such an analysis by using either a simple background
      character or a background index obtained as a linear function of two, or more
      than two, background characters. It is believed that the use of this approach
      would greatly increase the efficiency of selection and shorten the time needed to
      produce improved new crop cultivars. As the analyses require the handling of
      large amounts of measurement data, plant breeders must use computer facilities.

PMID- 1032103
TI  - Heritability estimates from four generations of a diallel cross of common wheat.
AB  - The heritabilities of 10 quantitative characters were studied on F1, F2,
      backcross, and selfed backcross generations of a five-parent diallel cross of
      common wheat grown at two locations. From this study it was found that (a) most
      of the characters in question were highly heritable, (b) the heritabilities
      estimated by regression and variance component methods were more or less the same
      (r=0.84** to 0.95**), and (c) the heritability of some characters was affected by
      location or by generation; in one case only (1000-kernel weight) was the
      heritability of the character affected by both.

PMID- 1032104
TI  - Diallel analysis of four agronomic traits in common wheat.
AB  - The common wheat cultivars Akoz, Florence, Mentana, Jaral, and Siete Cerros were
      crossed in 1972 in all possible combinations excluding reciprocals. In 1972--1973
      the F1 hybrids and the five parents were field grown at Bornova in randomized
      complete blocks. The characters studied were plant height, spike length, 1000
      kernel weight, and plant yield. The analysis of data showed that (a) with respect
      to plant height and 1000-kernel weight all F1 combinations deviated from the
      corresponding midparental values, (b) for the same characters the GCA variances
      were significant and the GCA divided by SCA ratios high, (c) the characters'
      plant height, spike length, and 1000-kernel weight were probably controlled by
      two effective factors each, and (d) plant height had the highest and 1000-kernel
      weight the lowest heritability (h2=0.66 and h2=0.26, respectively). It was
      concluded that a desired response to selection could be expected for plant height
      and 1000-kernel weight.

PMID- 1032105
TI  - Quantitative genetically nonequivalent reciprocal crosses in cultivated plants.
AB  - Quantitative expressions of character difference between reciprocal crosses have
      been studied by different researchers in a number of plant species, such as
      Epilobium, Zea mays, Oryza sativa, Hordeum sativum, Triticum aestivum, Trifolium
      hybridum, Linum usitatissimum, Nicotiana rustica, and others. In all cases it was
      found that the nonequivalence of reciprocal crosses manifested itself beginning
      with the F1 generation, with the exception of some flax crosses in which
      reciprocals differed beginning with the F2 generation. The nonequivalence of
      reciprocal crosses usually manifested itself in the inequality of their F1 and/or
      F2 or backcross means; however, there were instances in which their means were
      the same but the variances were different. Both matroclinous and patroclinous
      inheritances were reported in plants. Because of the casual complexity of
      reciprocal differences the experimental results often lack a simple explanation.

PMID- 1032106
TI  - Plant responses to high temperatures.

PMID- 1032107
TI  - Effect of high-temperature stress on the growth and seed characteristics of
      barley and cotton.
AB  - The existence of a sensitivity gradient to a uniform high-temperature stress
      applied at stages during seed maturation can be demonstrated in barley. The
      germination of freshly harvested seed is depressed following heat stress at 7--10
      days after awn emergence, but is enhanced by the same stress applied 3 weeks
      after awn emergence. The depression is attributed to reduced viability associated
      with thermal injury. The stimulation following stress at more mature stages of
      seed development is related to a thinner seed coat, increased permeability as
      evidenced by faster imbibition rate, and decreased content of water-soluble
      inhibitors in the seed. These effects of environmental stress during seed
      maturation aid in explaining differences noted in the germinability at harvest of
      seed produced in successive years or produced in the same year at different
      locations. Seed of American Cotton, var. AC 134, was stressed at 50 degrees, 60
      degrees, 70 degrees, 80 degrees, and 90 degrees C for 24 or 48 h before seeding.
      Stresses at 50 degrees to 70 degrees C increased seedling emergence and
      subsequent performance of the cotton plants, but higher temperatures caused
      thermal injury or killed the seed.

PMID- 1032108
TI  - Plant genotype effects on nitrogen fixation in grasses.

PMID- 1032109
TI  - Storage proteins in cereals.

PMID- 1032110
TI  - Wheat protein.
AB  - Results from AID-supported Nebraska research to improve the nutritional quality
      of wheat indicate that substantial genetic variation for grain protein content
      exists in wheat. Experimental lines with 5% higher protein in their grain than
      ordinary varieties have been selected from a high-protein X high-protein cross.
      Genetic variablity for lysine in wheat grain is limited. The genetic component of
      total lysine variability among 12,6000 wheats in the USDA World Collection was
      only 0.5%. Genetic increases in lysine ranging from 0.4 to 0.7% lysine have been
      identified in selections from a high-lysine X high-lysine cross. Lysine per unit
      protein is negatively correlated with protein content. In contrast, lysine per
      unit weight of grain is positively correlated with protein content suggesting
      that increasing the protein content of wheat can effectively increase the amount
      of lysine in the grain. Seed fractionation studies have determined that high
      protein in whole wheat results mainly from increased protein content of the
      starchy endosperm. Lysine differences were detected both in the endosperm and
      nonendosperm fractions. A new productive high-protein hard winter wheat variety
      derived from Atlas-66, with genetic potential for 2% higher grain protein content
      was released to growers by the Agricultural Research Service, USDA and the
      Nebraska Agricultural Experiment Station in 1975.

PMID- 1032111
TI  - The variability of free amino acids and related compounds in legume seeds.

PMID- 1032112
TI  - A genetic approach to the increase of methionine content in legume seeds.

PMID- 1032113
TI  - Unconventional methods in plant breeding.
AB  - There are three wass whereby unconventional methods of plant genetics can be used
      for applied plant breeding. 1. The time necessary for breeding by recombination
      can be shortened, making use of the discovery that plants can be obtained
      directly from the products of meiosis, the "Gonen." Two new cultivars bred in
      tobacco by this method already exist. 2. Microbiological methods may be applied
      to mutation and selection in haploid or dihaploid cell cultures. New cultivars
      bred by this method have not yet been published, but it should be possible to
      make use of this technique in plant breeding. 3. Somatic hybridization of plants
      by fusions of protoplasts or by uptake of nuclei and other organelles (plastids,
      mitochondria) or pure nucleic acids is another useful method. There exist up to
      now somatic hybrid plants (a) between mutants of the liverwort Sphaerocarpos
      donnellii, (b) some varieties of tobacco, and (c) two species of Nicotiana. All
      these hybrids can also be produced by conventional sexual hybridization. It is
      impossible to predict how often incompatibility for cross-fertilization can be
      surmounted by somatic hybridization, as incompatibility between two genomes must
      be restricted to the fertilization process, but it can work on any stage of the
      development of the hybrid.

PMID- 1032114
TI  - Distribution patterns of indigenous wheat varieties in Northern Pakistan.

PMID- 1032115
TI  - Inaugural address: development of new plant types.

PMID- 1032116
TI  - Pituitary apoplexy, therapeutic assessment.
AB  - The management of pituitary apoplexy with reference to both diagnosis and
      operative sequelae remains a major challenge. Acute onset of retro-orbital
      headache in association with visual loss and ophthalmoplegia are the cardinal
      symptoms; however, obtundation and signs of subarachnoid hemorrhage also may be
      present. Good quality plain skull radiographs and complete angiography prove
      sufficient for preoperative radiographic studies. Preoperative endocrine
      preparation focuses on supplemental glucocorticoids since these patients must be
      presumed deficient in cortisol reserve. Residual visual deficit appears to be
      more a function of the extent of damage at the time of ictus rather than rapidity
      of decompression. Our experience indicates that transsphenoidal decompression in
      appropriate cases offers an ideal opportunity to minimize mortality and
      morbidity. The acute onset of severe retro-orbital headache in association with
      stupor and ocular palsies would alert most physicians to the potential diagnosis
      of spontaneous subarachnoid hemorrhage. The association of complex
      ophthalmoplegias and visual defects in this constellation of symptoms should, in
      addition, alert one to the possibility of an acute intrasellar or parassellar
      expansile process. During the past two years, we have had the opportunity to care
      for 8 such patients with confirmed diagnoses of acute hemorrhagic infarction of
      the pituitary enabling us to formulate diagnostic and therapeutic schemata with
      reference to management of this problem.

PMID- 1032117
TI  - A simple method for continuous pressure recording.
AB  - A relatively simple, nonoperative, percutaneous procedure for recording
      continuous cerebrospinal fluid pressure was carried out on 12 patients at UCLA
      Hospital. The experience with pressure recording in these patients has
      demonstrated no mortality or permanent sequelae and the technical character of
      the records has been excellent. This technique could make continuous pressure
      recording more easily available to the average practioner. Other uses for this
      procedure are also suggested.

PMID- 1032118
TI  - Selective radiofrequency heating of ferrosilicone occluded tissue: a preliminary
      report.

PMID- 1032119
TI  - What is a pain center?
AB  - The authors present the concept that a multi-disciplinary interdepartmental pain
      center should include: 1) an initial out-patient pain clinic, 2) an inpatient
      pain service for diagnosis of pain problems and treatment of patients with
      intractable pain, including pain from cancer, 3) a psychotherapeutically-oriented
      chronic benign Pain Unit, 4) facilities for clinical and basic pain research, and
      5) affiliations for an adequate teaching program.

PMID- 1032120
TI  - Sensitivity to some rubber additives.
AB  - The frequency of positive patch tests to 13 rubber accelerators in Poland was
      recorded. Of particular interest was the relatively large group of patients
      positive to several, mostly chemically unrelated, accelerators. The mechanism of
      this multiple sensitivity is discussed. Positive tests to N-isopropyl-N-phenyl-p
      phenylenediamine were observed in more than half of the patients reacting to
      several aromatic amines. Anamnesis indicated that in the case of cross-reactions
      to many aromatic amines, none of the patients positive to N-isopropyl-N-phenyl-p
      phenylenediamine had complained of a reaction to rubber products.

PMID- 1032121
TI  - The safety of topical erythromycin.
AB  - The prevention of allergic complications depends on the use of topical
      medications which have proved to be rare sensitizers. This is particularly true
      for stasis ulcers and eczemas which are notoriously readily sensitized. Topical
      erythromycin has proved to be such a non-sensitizing topical antibiotic. In a
      series of 60 patients with stasis ulcers, erythromycin in the form of Ilotycin
      ointment (erythromycin in petrolatum) was applied. Not a single instance of
      allergic sensitization occurred. No instances of sensitization with positive
      patch tests to topical erythromycin have been reported. Maximization tests with
      topical erythromycin did not produce sensitization. Topical erythromycin, an
      effective antibiotic, should be substituted for neomycin which is a common
      sensitizer.

PMID- 1032122
TI  - Allergic contact dermatitis and conjunctivitis to corticosteroids.
AB  - This is a report of two patients suspected of having allergic dermato
      conjunctivitis due to corticosteroids. Both were tested with the constituents of
      the ointments they were using, that is, corticosteroids, antibacterial agents,
      preservatives, and other active ingredients of the ointment bases. Both patients
      showed positive allergic patch test reactions to the respective corticosteroid
      betamethasone valerate, and one to hydrocortisone, neomycin, and a rubber
      additive. The importance of routine patch testing in ophthalmic practice to
      detect sensitizers in cases of allergy is mentioned. Hydrocortisone (25%) in
      petrolatum is recommended for patch testing.

PMID- 1032123
TI  - Sensitizing and irritating properties of star anise oil.
AB  - Star anise oil in 2 and 1% concentrations produced active sensitization in 5% of
      test subjects, and positive patch tests in 36 and 34%, respectively, of
      consecutive patients with dermatitis. A comparison of the results of tests with
      balsams and other essential oils showed that star anise oil does not give cross
      reactions and pseudo cross-sensitivity. Patients positive to this oil are
      frequently positive to anethole and to other constituents of this oil: alpha
      pinene, limonene and safrole. In tests with star anise oil it is noteworthy that
      a 1% concentration is strongly irritant, and 0.5% reveals sensitivity in only one
      fifth of the actively sensitized subjects. It is possible that the cause of false
      negative patch tests might be similar in the case of some other allergens.

PMID- 1032124
TI  - Patch tests with potassium dichromate removed after 24 and 48 hours.
AB  - The rate of release in vitro of four potassium dichromate concentrations (0.5,
      0.1, 0.05 and 0.01%) was determined. In the course of 24 h, 90.1-97.5% was
      released of the total K2Cr2O7 amount in 48 h. Out of 30 patients positive to
      0.05% dichromate when the patch test was done routinely, 29 were also positive
      when the patch was removed after 24 h. The effect of the earlier removal of the
      patch test was also noted in seven other patients, when results of tests with
      lower dichromate concentrations were taken into account.

PMID- 1032125
TI  - Effects of vehicles and elicitation concentration in contact dermatitis testing.
      I. Experimental contact sensitization in humans.
AB  - A study was made to evaluate the effects of vehicle and challenge concentration
      on response of human subjects to potential allergens. In the vehicle studies the
      modified Draize test was used to test the response of subjects to cinnamic
      aldehyde and to costus oil, administered at two skin sites, in petrolatum and in
      95% ethyl alcohol. In two tests of costus oil, alcohol proved to be more
      effective in eliciting a response than petrolatum; on the other hand, in one test
      with cinnamic aldehyde, no difference in results was obtained with these two
      vehicles. In the concentration studies, subjects known to be sensitive to the
      test substance were tested by the Al test with costus oil (three concentrations),
      chloracetamide (four concentrations), or thimerosal (three concentrations);
      petrolatum was used as the vehicle in each case. Results of the vehicle test
      showed no compelling reason for the selection of one vehicle rather than another.
      Results of the concentration tests indicated that concentration does have an
      effect on the intensity and frequency of reactions to potential allergens.

PMID- 1032126
TI  - Effect of vehicles and elicitation concentration in contact dermatitis testing.
      II. Statistical analysis of data.
AB  - Data obtained in tests of several potential allergens with different vehicles and
      at different concentrations have been analyzed statistically.

PMID- 1032127
TI  - Comparison of guinea pig sensitization methods.
AB  - Up to now, different methods in guinea pig sensitization were used, to assess
      contact sensitization potential of low molecular weight chemicals. In order to
      compare the efficiency of the epicutaneous, intradermal and combined
      sensitization methods, two stronger sensitizers, the water soluble
      chlormethylimidazoline hydrochloride (CMI) and the lipid soluble 1,3
      dinitrochlorobenzene (DNCB) were used for the experiments. Eleven modified
      sensitization methods were performed. In a first trial each substance was tested
      on 10 animals. In a further study those techniques which had produced the best
      results, that is the highest degree of sensitization, were applied to 25 to 30
      animals. For comparison of the results of the various methods, a mean
      sensitization index was calculated. The best results were achieved with the
      Maximization Test of Magnusson & Kligman (1969) and the Split Adjuvant Technique
      of Maguire & Chase (1967).

PMID- 1032128
TI  - The investigation of quindoxin photosensitivity.
AB  - Quindoxin (quinoxaline di-N-oxide) is a photosensitizer capable of producing
      photocontact dermatitis. The study of a group of seven affected subjects has
      provided evidence of persistent light reaction and "photoallergy", most probably
      to the parent substance and not to any photoproduct or contaminant. Clinical and
      photobiological similarities to the photosensitivity dermatitis and actinic
      reticuloid syndrome were demonstrated.

PMID- 1032129
TI  - Nickel dermatitis--nickel excretion.
AB  - Nickel excretion in urine in four females sensitive to nickel with an
      intermittent dyshidrotic eruption was measured with flameless atomic absorption.
      Excretion of nickel was found to be increased in association with outbreaks of
      vesicles. The results support the idea that the chronic condition was maintained
      by ingestion of nickel in food.

PMID- 1032130
TI  - Nickel vasculitis.

PMID- 1032131
TI  - Water solubility of zinc chromate primer paints used as antirust agents.

PMID- 1032132
TI  - Immediate reactions to balsam of Peru, cassia oil and ethyl vanillin.

PMID- 1032133
TI  - Connubial contact dermatitis to benzoyl peroxide.

PMID- 1032134
TI  - Black discoloration of jewellery.

PMID- 1032135
TI  - Immediate- and delayed-type allergy to erythromycin.

PMID- 1032136
TI  - [Experimental study of changes in intrauterine spermatozoa].

PMID- 1032137
TI  - [Method of sterility studies with special reference to the infectious factor].

PMID- 1032138
TI  - Protein status in bilharziasis in Egyptian children.
AB  - Fifty-nine bilharzial subjects aged 9-12 years and 18 parallel controls were
      investigated for total serum proteins, total liver proteins and total urinary
      proteins. Simple agar gel and immunoelectrophoretic studies were also carried
      out. The results revealed a highly significant decrease in serum total proteins
      in mixed infection. A very highly significant increase was demonstrated for serum
      alpha, globulin. The gamma globulin fraction and the total globulin moiety were
      very highly significantly raised. The albumin globulin ratio was considerably
      decreased in mansoniasis. Serum immunoelectrophoresis illustrated a decreased
      density of haptoglobulin, hemopexin and transferrin arcs, as well as a
      considerable increase in IgA, IgM and IgG in most of the cases. Urinary protein
      values were very highly significantly elevated in hematobiasis and mixed
      infection. A slight increase for alpha1, alpha2 and beta-globulins was found in
      some cases. Liver proteins were very highly significantly decreased in
      mansoniasis and mixed infection. The results are discussed and analysed.

PMID- 1032139
TI  - Platelet function by afibrinogenemia.
AB  - Platelet function was studied in two cases with congenital afibrinogenemia. In
      these two cases there was no aggregation by ADP, while, there was increased
      calcium-induced platelet aggregation and decreased platelet adhesiveness to
      glass. Platelet aggregation was corrected in vitro, by addition of fibrinogen. It
      can be concluded from the above findings that the fibrinogen is an important
      factor for platelet aggregation by ADP and for platelet adhesion to glass
      surfaces, while platelet aggregation by thrombin does not need fibrinogen. The
      increased calcium-induced aggregation can be explained by postulating that
      thrombin finds no substrate to act upon except the platelets.

PMID- 1032140
TI  - Studies on platelet function in cases of hemophiliac Egyptian children.
AB  - Eleven cases of hemophilia were studied for detection of any change in the
      platelet function. The results showed hyperfunction in 5 cases, normal function
      in 4, and hypofunction in the remaining two. The hyperfunction of the platelets
      was shown in the case with acute hemorrhage and it might be a compensation
      mechanism. The normal function was shown in cases during the quiescent phase. The
      hypofunction of the platelets was associated with the presence of AHg inhibitor
      and platelet antibody. Normal function returned after Cortisone administration.
      It may be postulated that the inhibitor of factor VIII and the platelet antibody
      are one and the same thing.

PMID- 1032141
TI  - A clinical study of naproxen in rheumatoid arthritis.

PMID- 1032142
TI  - Biological studies of the rate of alimentary absorption and urinary excretion of
      tolbutamide and certain newly synthesized chemically related congeners in
      rabbits.

PMID- 1032143
TI  - Liver function tests in rheumatoid arthritis. A study of the so-called
      "rheumatoid liver".

PMID- 1032144
TI  - Cholinesterase activity in some human lymphatic organs.

PMID- 1032145
TI  - Effect of doxycycline administration on nitrogen excretion in bilharzial hepatic
      fibrosis and chronic renal failure cases.

PMID- 1032146
TI  - Sex chromatin pattern in patients with advanced cancer breast.

PMID- 1032147
TI  - Evaluation of cardiac efficiency (a preliminary note on a new method).

PMID- 1032148
TI  - The role of fibroscopy in diagnosis of upper gastrointestinal disease.

PMID- 1032149
TI  - Clinical and biochemical study of serum iron and trace elements in patients with
      pulmonary tuberculosis.

PMID- 1032150
TI  - A study of portosystemic collaterals by the intrasplenic injection of radio
      iodinated macro-aggregated human serum albumin (MAAI131).

PMID- 1032151
TI  - Comparative pharmacological study of the neuromuscular blocking action of some
      antibiotics.

PMID- 1032152
TI  - Vascularization of the femur and tibia in the human foetus.

PMID- 1032153
TI  - Nervous mechanisms involved in angiotensin action.

PMID- 1032154
TI  - [Isolation of antibiotic-resistant bacteria in the water of streams subject to
      different degrees of pollution].

PMID- 1032155
TI  - [Chemical, bacteriological and virological studies of water collected in the
      vicinity of Rome, with special reference to the detection of polycyclic aromatic
      hydrocarbons and mercury].

PMID- 1032156
TI  - [Mechanisms of antibiotic-resistance in Pseudomonas].

PMID- 1032157
TI  - [Tinea profunda and working conditions].

PMID- 1032158
TI  - [Clinical symptoms and results of tests of the skin vascular system in workers of
      a food-freezing plant].

PMID- 1032159
TI  - [Most frequently occurring contact allergens in Poland].

PMID- 1032160
TI  - [Occurrence of latent allergy to standard allergens depending on age].

PMID- 1032161
TI  - [Contact eczema among patients treated at the Provincial Dermatological
      Dispensary in Bydgoszcz].

PMID- 1032162
TI  - [Contact allergy, susceptibility factors and rehabilitation of patients treated
      at the Department of Dermatology of the Postgraduate Training Center of the
      Military Medical Academy].

PMID- 1032163
TI  - [Capillaroscopic picture of the nailfolds in patients with eczema].

PMID- 1032164
TI  - [Glucose tolerance test in patients with eczema and atopic dermatitis].

PMID- 1032165
TI  - [Analysis of cases exhibiting positive reactions to scarification tests with
      pollen allergens].

PMID- 1032166
TI  - [Analysis of cases of endogenous eczema hospitalized at a children's
      dermatological ward during the last 4 years].

PMID- 1032167
TI  - [Treatment of endogenous eczema with epsilon-aminocaproic acid].

PMID- 1032168
TI  - [Treatment of allergic diseases with cyproheptadine].

PMID- 1032169
TI  - [Effect of imuran on experimental eczema].

PMID- 1032170
TI  - [Ultrastructure of urticaria].

PMID- 1032171
TI  - [Allergy pattern to Para group compounds].

PMID- 1032172
TI  - [Various immune phenomena in atopic dermatitis].

PMID- 1032173
TI  - [Allergy caused by mould fungi in urticaria].

PMID- 1032174
TI  - [Serum zinc levels in selected cases of allergic reactions].

PMID- 1032175
TI  - [Occurrence of basophils in various allergic skin diseases].

PMID- 1032176
TI  - [Photoallergic and phototoxic effects. Methods of detection].

PMID- 1032177
TI  - [Immunological phenomena in light hypersensitivity].

PMID- 1032178
TI  - [Is alopecia areata an autoimmune disease?].

PMID- 1032179
TI  - [Studies of sera yielding biologically false reagin test results and sera from
      patients with autoimmune diseases and neoplasms. Treponemal tests].

PMID- 1032180
TI  - [Melanocytes and melanophages in autoimmune diseases].

PMID- 1032181
TI  - [Cellular immunity in lupus erythematosus and scleroderma].

PMID- 1032182
TI  - [Toxic and allergic effects of various epoxy resins and their hardners].

PMID- 1032183
TI  - [Immunotherapy in dermatology].

PMID- 1032184
TI  - [Viral etiology of autoimmune diseases (electron microscopic studies)].

PMID- 1032185
TI  - Investigation about the etiology of keratoacanthoma.

PMID- 1032186
TI  - [Electron microscopic studies of renal involvement in systemic scleroderma].

PMID- 1032187
TI  - [Treatment of diffuse scleroderma with heparin].

PMID- 1032188
TI  - [Trafuril reaction in scleroderma].

PMID- 1032189
TI  - [Dermatomyositis in the records of the Department of Dermatology of the Medical
      Academy of Poznan].

PMID- 1032190
TI  - [Epidemiological incidence of venereal diseases in various Polish provinces].

PMID- 1032191
TI  - [Changes occurring in the nervous system in the course of early syphilis].

PMID- 1032192
TI  - [Evaluation of routine serologic diagnosis in Poland].

PMID- 1032193
TI  - [Fluorescent method in the diagnosis of non-symptomatic trichomiasis in humans].

PMID- 1032194
TI  - [Yeast-like fungi within the mucous membranes with special consideration of the
      lower part of the urogenital tract].

PMID- 1032195
TI  - [Tropical venereal disease brought to Krakow (2 cases of lymphogranulomatosis
      inguinalis)].

PMID- 1032196
TI  - [Study of cellular immunity in syphilis using lymphocyte transformation and
      macrophage migration inhibition tests].

PMID- 1032197
TI  - [Blood serum IgG content in early syphilis].

PMID- 1032198
TI  - [Oletetrin in the treatment of gonorrhea in men].

PMID- 1032199
TI  - [Treatment of gonorrhea with Rimactan Ciba].

PMID- 1032200
TI  - [Mechanism of carbodiimide contact allergy in guinea pigs].

PMID- 1032201
TI  - [Methods and epidemiologic usefulness of prophylactic testing for gonorrhea in
      women].

PMID- 1032202
TI  - [Nelson-Mayer test in treated secondary recurrent syphilis].

PMID- 1032203
TI  - [Treatment with Solcoseryl of refractory leg ulcer of diverse etiology].

PMID- 1032204
TI  - [Contemporary methods of psoriasis treatment].

PMID- 1032205
TI  - Treatment of psoriasis.

PMID- 1032206
TI  - [Adverse effects of topically applied corticosteroids].

PMID- 1032207
TI  - [Role of rubber accelerators in the etiology of leg eczema in miners].

PMID- 1032208
TI  - [Dermatological evaluation of soaps, pastes and liquids used in for skin
      cleansing in factories].

PMID- 1032209
TI  - [Vibration disease considered as a dermatological problem].

PMID- 1032210
TI  - [Comparative evaluation of the action of various anti-adhesive oils on the skin
      in mice].

PMID- 1032211
TI  - Discharge pattern and recruitment order of motor units in man.

PMID- 1032212
TI  - [Left hemisphere lesion and visual recognition of single letters (author's
      transl)].
AB  - 100 Controls and 200 left hemisphere-damaged patients were sub-divided by means
      of a Standard Language Battery in 35 non Aphasic patients, 51 Broca's aphasic
      patients, 85 Wernicke's aphasic patients and 29 global aphasics. They were all
      submitted to a single letter recognition test. From a parametric statistical work
      out of the experimental data, it turned out that global aphasics are by far the
      most impaired experimental group, even if their performance had been adjusted by
      co-variance taking into account their more relevant aphasic and neurological
      disorders. Whilst age and length of illness do not play a significant role in the
      test performance, this was significant for the educational level (years of
      schooling) and for the severity of the aphasic disorders (Token Test). The
      relationship between the above-mentioned independent variables and the letter
      recognition scores did not change significantly across the experimental groups.
      The only exception was that the relation between the Token Test and the letter
      recognition scores proved to be significantly different between Broca's and
      Global Aphasics. No definite conclusion could be drawn about the outstandingly
      poor scores of global aphasics, as neither their performance or their I.Q.
      (W.A.I.S.) seemed to be related to the letter recognition scores (in contrast
      with Broca's and Wernicke's aphasics), nor to the presence of retro-geniculate
      visual field defects.

PMID- 1032213
TI  - [Clinical and anatomical features of a case of Schilder's disease (author's
      transl)].
AB  - A case of a Schilder's disease (1912 type) in a seven year old boy is described.
      The patient died after four months and autopsy was performed. The most important
      clinical features are represented by repeated electroencephalograms, immunologic
      investigations in both plasma and CSF as well as tests of adrenal function.
      Histopatological examination of the brain shows a diffuse sudanophilic
      orthocromatic demyelinating process of both hemispheres with intense vascular
      cuffing, microglial proliferation and astrocytic hypertrophy. These findings are
      in contrast with some recent statements in the literature which reject a
      nosographic individuality to Schilder's disease and describe
      "Adrenoleukodystrophies" on doubtful criteria.

PMID- 1032214
TI  - [Epidemiological observations on plasma levels of diphenylhydantoin in 130
      patients on prolonged treatment (author's tranls)].
AB  - Plasma levels of diphenylhydantoin have been measured in 130 epileptic patients
      undergoing long-term anticonvulsant therapy. Only in a small percentage of the
      patients (15,38%) plasma levels were found to lie within the therapeutic range.
      Most patients (75,38%) exhibited subtherapeutic values, while in a few cases
      (9,24%) the upper limit of therapeutic range was exceeded. Although plasma
      concentrations significantly correlate with the administered dose, predictability
      of plasma levels in the individual patients given fixed dosage schedules is
      strongly limited by large interindividual variability. Sex, age and simultaneous
      administration of other drugs seem not to affect significantly DPH plasma levels.
      Our observations carried out in a meaningful sample of epileptic patients suggest
      that at present the practice of monitoring diphenylhydantoin plasma levels is
      still an essential tool for the management of epilepsy when a safe and effective
      therapeutic regimen is required.

PMID- 1032215
TI  - [Proteolipids of myelin isolated from rat brain].

PMID- 1032216
TI  - [Shifts in several aspects of phospholipid metabolism in the brains of white rats
      with radiation sickness].
AB  - Sublethal (400) and lethal (1600) doses of roentgen decrease the level of neutral
      phospholipids of rat brain and increase that of acid phospholipids. With the
      development of radiation disease the content of free glycerine and
      glycerophosphate increases and the glycerokinase and glycolytic pathways of
      glycerophosphate biosynthesis are activated together with the intensification of
      the direct and reverse reactions catalyzed by glycerophosphate dehydrogenase. The
      permeability of the artificial bimolecular phospholipid membranes prepared from
      rat brain phospholipid extracts is significantly increased at the end of the
      radiation.

PMID- 1032217
TI  - [Changes in the ribonuclease activity of brain cell nuclei and mitochondria at
      different periods following removal of the superior cervical sympathetic
      ganglion].
AB  - A study of the changes in the ribonuclease activity of nuclei and mitochondria of
      rat brain cells following 1, 3, 7, 20 and 90 days after extirpation of the right
      superior cervical ganglion showed an increase of enzyme activity in nuclei from
      the first up to the 90-th day following removal of the ganglion. During the first
      three days after the operation enzyme activity is higher in nuclei obtained from
      the intact (left) side of the brain while later on enzyme activity is more
      pronounced in nuclei obtained from the right (sympathectomized) side of the
      brain. In mitochondria enzyme activity is depressed during the whole period
      studied after sympathectomy (90 days).

PMID- 1032218
TI  - [Proteins, polypeptides and amino acids of the nervous system according to
      materials of the 5th international meeting of the International Society of
      Neurochemistry (Barcelona, 2--6 September, 1975)].

PMID- 1032219
TI  - [Effect of diethylstilbestrol and steroid hormones on glutaminase activity in the
      mitochondrial fraction of rat brain].

PMID- 1032220
TI  - [Effect of neurohormone "C" on adenine nucleotide and adenosine metabolism in rat
      heart and brain].
AB  - Adenine nucleotides and adenosine are known to be of importance in the regulation
      of coronary function. This made a study of the effect of neurohormone "C" on the
      metabolism of adenine nucleotides and adenosine interesting in as much as
      neurohormone "C" dilates coronary vessels and has a direct metabolic effect on
      cardiac muscle. The results obtained have shown that incubation of cardiac muscle
      homogenates with labelled ATP increased the content of adenosine through raising
      5'-AMP nucleotidase activity and inhibiting adenosine deaminase activity. In
      homogenates and slices of brain tissue the content of adenosine is, on the
      contrary, reduced. Opposite changes are observed in the content of AMP. The
      increase of adenosine in the heart by the increase of 5'-AMP nucleotidase
      activity and decrease of adenosine deaminase activity is probably, not the main
      factor of the coronarodilatatory effect of neurohormone "C". The reverse
      phenomena is noticed in brain, the functional significance of which must be
      studied. However, the role of adenosine in the mechanism of action of
      neurohormone "C" will become clear after in vivo experiments which are in
      progress.

PMID- 1032221
TI  - [Glutamic acid oxidation and its regulation in purified mitochondria and nerve
      endings of rat cerebral cortex].
AB  - A comparative study of respiration of mitochondrial and synaptosomal fractions of
      adult rat brain cerebral cortex has shown that glutamic acid is oxidized in both
      fractions and that its oxidation is potentiated by ADP. Addition of ADP has,
      however, a different effect on the endogenous respiration of these two fractions;
      while it has no effect on the endogenous respiration of the synaptosomal
      fraction, it increases considerably the weak endogenous respiration of the
      mitochondrial fraction.

PMID- 1032222
TI  - [Formation of ammonia from glutamic acid and ADP in purified mitochondria and
      nerve endings of rat cerebral cortex].
AB  - The aim of the present study was to elucidate the formation of ammonium and its
      quantitative interrelationship in mitochondrial and synaptosomal fractions
      obtained from rat cerebral cortex. The data obtained have shown that in
      mitochondrial fraction the level of ammonium is high while its endogenous
      formation is less pronounced. A large amount of ammonium is formed from ADP and
      some from glutamic acid, especially in the presence of ADP. The level of ammonium
      is, on the contrary, low in the synaptosomal fraction and endogenous ammonium
      formation is high. In this fraction also there is ammonium formation from both
      ADP and GA but to a smaller extent than in the mitochondrial fraction. The data
      obtained make up conclude that the formation of ammonium by the
      glutamatedehydrogenase pathway in the presence of activators is an important
      mechanism in mitochondria but not synaptosomes.

PMID- 1032223
TI  - The substrate specificity of an aminopeptidase (neutral arylamidase) from pig
      brain.
AB  - Neutral arylamidase of pig brain has been purified 235 fold. At this purification
      the major band on disc-gel electrophoresis is associated with the enzyme
      activity, although several minor components are also present. The arylamidase is 
      SH dependent and puromycin inhibited. It has activity toward lysyl and arginyl
      beta-naphthylamides as well as toward the beta-naphthylamides of a large variety
      of neutral amino acids. The enzyme is strongly substrate inhibited, making the
      relative order of reactivity to aminoacyl beta-naphthylamides dependent upon the
      substrate concentration chosen for comparison. It also shows activity toward
      certain di-, tri-, and oligopeptides. When more than one residue is cleaved, the
      release is sequential, starting from the amino terminus of the peptide. It
      appears therefore that pig brain neutral arylamidase is an aminooligopeptidase of
      broad specificity. We suggest that beta-naphthylamides are model substrates
      representing the N-terminal end of peptides with three or more residues. The
      properties of pig brain enzyme are similar in many respects to those previously
      isolated from rat and bovine brain and bovine pituitary.

PMID- 1032224
TI  - [Homocarnosine metabolism in brain tissue].
AB  - In glial tumors of human brain the content of homocarnosine has been found to be
      lower than in brain tissue. In experimental animals cranial injury induces an
      increase of homocarnosine in brain tissue. Stimulation of the nervous system of
      traumatized animals by phenamin brings the metabolism of homocarnosine back to
      normal. The results of these studies make us suppose that homocarnosine is a
      substance involved in brain activity.

PMID- 1032225
TI  - Intraaortic balloon pumping assist following open heart surgery for coronary
      artery disease.
AB  - Intraaortic balloon pump (IABP) assist was employed in 36 patients after surgical
      operation for coronary artery disease. In 31 patients, the aid of IABP was
      required because cardiopulmonary bypass could not be terminated without it. In
      three of these patients, IABP assist was started before the surgical procedure
      because these patients were in cardiogenic shock due to myocardial infarction. In
      the remaining five patients, IABP assist was applied for refractory cardiogenic
      shock in the early postoperative period. The overall survival rate was 58
      percent. IABP assist was used in 13 patients with an ejection fraction of 0.1 to
      0.2 (normal 0.7). Nine of these patients survived. From our experience, it would
      appear that this temporary mechanical circulatory support provides a significant
      advantage in saving patients who might otherwise die after surgical procedures
      involving the coronary artery.

PMID- 1032226
TI  - Nosocomial vaccinia infection.
AB  - Although hospital-associated spread of vaccinia has been reported in the past,
      there have been no recent reports. This paper describes hospital-associated
      spread of vaccinia virus infection, supplies data on the environmental survival
      of vaccinia virus and offers recommendations for the management of patients with
      vaccinia that may minimize the hazard of infection in other high-risk patients.

PMID- 1032227
TI  - Pressure gun injection injuries of the hand.
AB  - Pressure gun injection injuries are becoming increasingly common. Their effect on
      the fingers and hands, especially when improperly managed, can be devastating.
      Therefore it is important to review features, clinical course, anatomic
      distribution and operative management of such injuries. If a useful hand and
      fingers are to be attained, rapid and thorough decompression and debridement of
      these injuries are essential.

PMID- 1032228
TI  - Acute iron poisoning in children.

PMID- 1032230
TI  - Another approach to health care problems?

PMID- 1032229
TI  - Rhabdomyolysis.

PMID- 1032231
TI  - Crohn's disease - a cause of arthritis, oxalate stones and fistulae in cystic
      fibrosis.

PMID- 1032232
TI  - Cysticercus cyst of temporal lobe presenting as a tentorial pressure cone.

PMID- 1032233
TI  - Radionuclide studies in coccidioidal meningitis.

PMID- 1032234
TI  - Parasitic infections among traveling students.

PMID- 1032235
TI  - Diethylstilbestrol in the treatment of rape victims.
AB  - Despite growing controversy surrounding its use as a "morning after pill,"
      diethylstilbestrol (DES) is prescribed liberally for rape victims. Guidelines for
      its use in these patients is lacking. Of 150 consecutive rape victims treated at
      a university medical center, 63 (42 percent) received prescriptions for DES. Of
      the 55 (87 percent) on whom follow-up was obtained, in 40 (73 percent) there were
      substantial side effects-nausea or vomiting, or both. At least six (11 percent)
      did not complete therapy because of these side effects. The authors offer
      guidelines for use of DES for rape victims and a plan for patient education and
      follow-up.

PMID- 1032236
TI  - Toe tourniquet syndrome.

PMID- 1032237
TI  - Chronic hepatitis; prognostic aspects.
AB  - Chronic hepatitis was diagnosed on the basis of biochemical, immunological and
      morphological criteria in 153 cases. On the evidence of observations for a mean
      period of four years the prognosis of chronic persistent hepatitis is regarded as
      favourable, no progression to chronic aggressive hepatitis or to cirrhosis having
      been observed in any of the cases. On the other hand, chronic aggressive
      hepatitis was found to progress to cirrhosis in 12 out of 65 cases. Cirrhotic
      transformation was more frequent in hyperactive processes (8 out of 25 cases).
      The sera of patients with primary hepatocellular carcinoma showed low
      immunoglobulin concentrations, with increased coeruloplasmin and reduced
      transferrin levels.

PMID- 1032238
TI  - Effect on carbohydrate metabolism of hypotensive adrenergic neurone blocking
      agents.
AB  - In subjects with normal metabolism sugar tolerance was not appreciable influenced
      by 4 or 5-day courses of guanethidine and guanazodine. Upon perfusion in isolated
      rat liver, glycogen metabolism and hepatic sugar release were increased by
      guanazodine, guanethidine and debrisoquine alike. However, when these drugs were
      used simultaneously with chlorpropamide debrisoquine proved to be the weakest in
      counteracting the inhibitory effect of chlorpropamide on glycogen metabolism and
      sugar release. The observation may have clinical significance.

PMID- 1032239
TI  - Myocardial lesions subsequent to roentgenotherapy.
AB  - The myocardium was studied for changes caused by therapeutical X-ray irradiation
      in a necropsy material of 14 cases. The lesions found in the myocardial vessels,
      in the parenchyma and in the interstitium are described in detail. While the
      severity of the vascular changes was independent of the radiation dose, the
      gravity of parenchymal lesions was closely related to the dose employed.

PMID- 1032240
TI  - [Assessment of creatine clearance in infants and determination of the serum
      creatinine level].

PMID- 1032241
TI  - Renal haemodynamics in mercuric chloride-poisoned dogs.
AB  - Intrarenal haemodynamics and glomerular dynamics have been investigated in dogs
      with mercuric chloride-induced acute renal failure. The early phase (12 and 24 hr
      after the intravenous injection of 2 mg/kg HgCl2) is characterized by some
      decrease in renal bloodflow, due to afferent (preglomerular) vasoconstriction,
      while in the later phase (48 and 72 hr after poisoning a pronounced increase in
      RBF due to efferent (postglomerular) vasodilatation supervenes. Urinary volumes
      amounts to normal in the early phase, followed by oligo-anuria in the 48 and 72
      hr groups. Extraction ratio of inulin, i.e. the filtration fraction and,
      consequently, glomerular filtration rate show a progessive decline and trend
      towards zero in the 72 hr group. The pronounced decrease in glomerular capillary
      pressure is due to both absolute and relative increase and decrease in afferent
      and efferent resistances, repectively. The progressive fall in effective
      filtration pressure is brought about by the decrease of glomerular capillary
      pressure, combined with increased colloid osmotic pressure due to
      haemoconcentration. Total and segmental intrarenal vascular resistances are
      reduced by hyperosmotic mannitol infusions resulting in renal hyperaemia.
      Glomerular filtration rate is, however, not influenced by mannitol and effective
      filtration pressure remains unaltered. Osmotic diuresis ensues in the early phase
      but urinary output is not restored in the late, i.e. oligo-anuric, phase.

PMID- 1032242
TI  - Effect of carotid occulsion on intrarenal haemodynamics.
AB  - Renal cortical medullary autoregulation was investigated by Sapirstein's 42K and
      86Rb isotope fractionation methods under pentobarbital anaesthesia in nondiuretic
      dogs under normal conditions and during carotid occlusion. Cortical circulation
      appeared to be autoregulated in both conditions while medullary blood flow showed
      moderate autoregulation in the control as well as during carotid occlusion. In
      contrast to expectation, medullary blood flow was not increased by the blood
      pressure elevation following carotid occlusion but was reduced as a consequence
      of the simultaneously evoked reflectory vasoconstriction. Carotid occlusion
      resulted in a more pronounced enhancement of vascular resistance in the medulla
      than in the cortex. It was concluded that non-uniform intrarenal distribution of
      the autoregulatory as well as the reflectory vasoconstriction left pressure and
      filtration rate essentially unchanged in the cortical glomeruli but increased
      both in the iuxtamedullary ones. Carotid-occlusion diuresis, therefore, cannot be
      explained by increased medullary blood flow but may be result of augmented flow
      rate of tubular fluid through the loops of Henle.

PMID- 1032243
TI  - Effect of alpha-pinene on the mixed function microsomal oxidase system in the
      rat.
AB  - The microsomal fraction of the liver was studied for protein and cytochrome P 450
      contents as well as for aminopyrine N-demethylase and aniline hydroxylase
      activity and for its butylisocyanide spectrum under the effect of alpha-pinene
      treatment. A moderate increase was found in the amount of microsomal protein and
      cytochrome P 450, a marked increase in the metabolism of both aminopyrine
      (substrate of type I) and aniline (substrate of type II), together with an
      increase in the butylisocyanide-absorption maxima of both haemoproteins involved
      in the reaction. Thus, alpha-pinene is a broad-spectrum enzyme inductor of the
      phenobarbital type, with certain quantitative differences.

PMID- 1032244
TI  - The structure of gastrointestinal hormones.
AB  - The primary and secondary structure of the three kinds of gastrointestinal
      hormones, i.e. gastrin, cholecystokinin-pancreozymin and secretin are discussed.

PMID- 1032245
TI  - Gastrointestinal peptide hormone analogues.
AB  - All derivatives of the C-terminal tetrapeptide fragment of gastrins with 17 amino
      acids elicit every physiological effect of the gastrin. This recognation led to
      detailed studies on the structure-activity relationships. In the case of
      cholecystokinin-pancreozymin, a substance consisting of 33 amino acids, the
      smallest sequence which possesses biological activity is the C-terminal
      octapeptide fragment. Synthesis of analogous derivatives of this fragment allowed
      the determination of the structural elements necessary to evoke the biological
      action.

PMID- 1032246
TI  - Metabolism of the gastrointestinal peptide hormones.
AB  - Results of investigations on the metabolism of gastrin, pentagastrin,
      cholecystokinin and secretin are discussed on the basis of data in the
      literature. Own results concerning the metabolism of 14C-pentagastrin are also
      described, out of which the significance of a biologically inactive metabolite is
      emphasized. This metabolite can be demonstrated in the circulation, and is
      excreted in the urine. As judged from the present state of investigations, this
      metabolite has a crucial importance in the metabolism of pentagastrin.

PMID- 1032247
TI  - Clinical significance and perspectives of gastrointestinal peptide hormones.
AB  - Present knowledge about gastrointestinal peptide hormones is discussed from three
      points of view: (a) diagnostic significance of these hormones; (b) states
      characterized by over-production or deficiency of peptide hormones; (c) clinical
      application and perspectives of gastrointestinal hormones. The data in the
      literature are subjected to a critical analysis; in  addition, the author's own
      experiments are discussed.

PMID- 1032248
TI  - Correlational analysis of the effects of cold, hypoxia, and hypercapnia on heat
      production and body temperature in the newborn and the adolescent guinea pig,
      with complementary data on young adult guinea pigs, new-born rabbits and rats.

PMID- 1032249
TI  - Oxygen uptake capacity of gills and skin in relation to body weight of the air
      breathing siluroid fish, Clarias batrachus (Linn.).
AB  - Oxygen consumption through gills and skin in relation to body weight was
      estimated in the air-breathing catfish, Clarias batrachus, under two experimental
      conditions, viz., (i) when access to air was allowed and (ii) when air-breathing
      was prevented. There was a positive correlation between VO2 (ml/hr) and body
      weight in both experimental conditions. Oxygen consumption (ml/hr) increased by a
      power of 0.869 when access to air was allowed whereas the power was slightly less
      (b = 0.841) when air-breathing was prevented. As the values for exponent (b) were
      less than 1.0, the weight specific VO2 (ml/kg/hr) decreased with increasing body
      weight. The decrease was more marked (b = - 0.180) in fishes which were not
      allowed air than in those where access to air was allowed (b = - 0.148). Under
      normal conditions of water and air-breathing the rate of VO2 (ml/kg/hr) via gills
      and skin from water ranged from 39.7 +/- 3.21 to 76.7 +/- 9.01 and this increased
      to 42.17 +/- 6.2 to 105.9 +/- 8.33 when air-breathing was prevented. The increase
      in the rate of VO2 was perhaps associated with the increase in the volume of
      water irrigating the gills per unit time.

PMID- 1032250
TI  - Intestinal transport of fructose and glycine in Ophiocephalus punctatus.
AB  - The regional variations in the absorption of fructose and glycine have been
      studied in the intestine and pyloric caeca of the fish, Ophiocephalus punctatus
      in vivo, by preparing intestinal sacs. Diffusion of amino acids out of the
      intracellular compartment of the intestine was observed in all the portions of
      the intestine. The pyloric caeca showed maximum transport of fructose. Absorption
      of fructose was slightly more in the posterior intestine than in the anterior
      intestinal sac. Maximum transport of glycine took place in the anterior
      intestinal sac. Pyloric caeca adsorbed more glycine than did the posterior sac.
      For both nutrients, the rate of uptake did not differ significantly in the upper
      and the lower portion of the intestine. In all the portions, the transport of
      fructose was more rapid than that of glycine. The experiments revealed that
      though the nutrients are absorbed in the entire length of the intestine, the
      quantity absorbed varies from one portion to another and is dependent on the
      nature of the compound absorbed.

PMID- 1032251
TI  - Influence of amino acids on gastric emptying in young pigs.
AB  - The effects of amino acids on gastric emptying and secretion were studied in four
      young conscious pigs provided with a chronic gastric cannula. A basal test meal
      of 500 ml containing 10 g citrus pectin, 17.5 g sucrose, 100 mg phenol red alone
      or with glycine, L- or DL-tryptophan, DL-methionine or L-glutamic acid was poured
      into the stomach and recovered 20 min later. Glycine at concentrations of 26.7-
      106.8 mM/l did significantly affect gastric emptying, although at the highest
      concentration gastric emptying appeared to slow down. L-lysine (41.0 mM/l), DL
      methionine (40.3 mM/l or L-tryptophan (29.4 mM/l did not significantly affect the
      rate of stomach emptying; L-tryptophan increased the amount of Cl- and H+
      secreted as compared with the basal diet alone. The effects of addition of the
      essential amino acids, L-lysine and DL-methionine, were compared with those of
      the nonessential glycine and L-glutamic acid. There was no significant difference
      in the rate of gastric emptying or secretion between them. The L and DL isomers
      of lysine and trypotphan were not found to differ significantly in their effects
      on gastric emptying and secretion.

PMID- 1032252
TI  - Cortical synchronization induced by thermal stimulation of the preoptic area in
      immobilized rats.
AB  - Cortical synchronization characterized by frontal spindles and occipital slow
      wave activity was induced by bilateral thermal stimulation of 2--4 degrees C of
      the preoptic area in unanaesthetized immobilized rats. The synchronization was
      demonstrated by ECoG and its power density spectra. The ECoG of the
      synchronization was similar to that of slow wave sleep. Switching off the thermal
      stimulation the original activity was recovered in most of the cases. Frontal
      spindle activity and slow wave activity recorded over the posterior cortex seemed
      to be dissociated to some degree. Low frequency stimulation at the points of
      thermal stimulation resulted in frequency following synchronization. In some
      cases electrical and thermal stimulation induced gradually developing seizure
      activity.

PMID- 1032253
TI  - Effect of TSH and melatonin on thyroid activity in the rat.
AB  - Melatonin and TSH, injected separately, caused no change of the blood thyroxine
      level at 30 min after treatment. Simultaneous or subsequent administration of the
      two hormones induced an increase of the level. Thus, melatonin is capable of
      potentiating acute, thyroxine mobilizing effect of TSH.

PMID- 1032254
TI  - The frequency dependence of evoked and postsynaptic potentials in the
      somatosensory cortex of the cat.
AB  - Intracellular records were made from neurones of the somatosensory cortex of
      cats, during stimulation of the ventrobasal complex of the thalamus. The aim of
      the experiments was to detect correlations between frequency dependence of
      surface evoked potentials and that of unit discharges. The amplitude of the
      surface evoked potential showed a strong diminution when the frequency of the
      thalamic stimulation was raised from 1 cps to 15 cps. In spite of this, frequency
      dependence in amplitude of unit discharges was never seen. As regards their
      frequency of occurrence the unit responses (full spikes, dendritic, postsynaptic
      potentials) behaved differently: a part of them showed increasing, another part
      gave decreasing occurrence, and the remaining portion did not change it. The
      authors conclude that temporal dispersion fails to give account for the frequency
      dependence, therefore further possibilities have to be examined.

PMID- 1032255
TI  - Relation of unit spike discharges and evoked potentials in the auditory cortex of
      cats.
AB  - Extracellular microelectrode recordings were made from the auditory cortex of
      anaesthetized cats during acoustic click stimulation. The microelectrode of low
      resistance allowed to record evoked field potentials and unit discharges
      simultaneously. In distant extracellular leads the relation of unit discharges
      and field potentials was equivocal. Near extracellular leads revealed that the
      antidromic invasion of the somadendritic membrane by excitation is a frequency
      dependent process (just as evoked field potentials) while spike potentials can
      reliably be elicited from the initial segment at high frequencies. It is assumed
      that the excitation spreading from the initial segment to the soma-dendritic
      membrane represents an important component of the evoked potentials, and their
      frequency dependence may be traced back to inhibitions activated by afferent
      impulses.

PMID- 1032256
TI  - A device for evaluation of the dominant component of the EEG activity.
AB  - A setup composed of a bioanalyser and additional electronic circuits is described
      allowing to measure the instantaneous frequency and amplitude of the dominant
      component of EEG activity. Besides recording the above values on paper by means
      of the EEG apparatus, functions of probability density of both the amplitude and
      the frequency of EEG activity are estimated on-line during preadjusted time
      intervals, and displayed on the screen of the bioanalyser. The mutual
      relationship between instantaneous EEG amplitude and frequency can be expressed
      in two-dimensional histograms displayed on a memory scope. The system described
      is suitable for laboratories having no possibility to use general purpose
      computer on-line.

PMID- 1032257
TI  - Assumed identity of granulocyte-pyrogen (GP) and leukocytosis inducing factor
      (LIF).
AB  - Pyrogen obtained from granulocytes induces granulocytosis in normal, endotoxin
      tolerant and spinal animals alike, whereas heat treatment destroys the
      granulocytosis inducing effect. It is concluded that GP and LIF are identical, or
      nearly identical, factors.

PMID- 1032258
TI  - Cardiovascular reactivity and neurogenic tone in unilateral renovascular
      hypertension in the rat.
AB  - The role of some mechanisms in the development of hypertension due to unilateral
      renal artery stenosis is influenced by the presence or absence of the intact
      opposite kidney. In this paper: a) the cardiovascular reactivity (CR) to
      norepinephrine (NE) and b) the effect of a ganglionic blocker (pentolinium, P)
      during the early (first two weeks) and later periods (ten weeks) of hypertension
      elicited by unilateral renal ischemia in the presence of the untouched
      contralateral kidney in the rat have been reported. Neither the threshold doses
      nor the dose-pressor response curves have shown a greater reactivity of the
      cardiovascular system to NE in this specific type of renovascular hypertension.
      An increase in the activity of the nervous system apparently contributes in early
      and late periods to the fuller development of high arterial pressure (AP).

PMID- 1032259
TI  - Effects of prostaglandins upon hair growth in mice.
AB  - The effect of prostaglandins upon the diffuse hair wave induced by gonadectomy
      was studied in male C3H mice. The drugs used were Prostaglandin E1 and
      Prostaglandin F2alpha, tromethamine salt, which were administered twice a day
      intraperitoneally during 22 days, in daily doses from 1 to 6 micrograms. The
      animals had their back clipped and were castrated at the beginning of each
      experiment. At the end of the 22 day experimental period while all the castrated
      control mice were completely covered by hair, in the castrated prostaglandin
      treated mice a marked inhibition of the hair growth was noticed.

PMID- 1032260
TI  - Electronic system for the obtention of phase plane curves for action potentials.
AB  - This system is designed for the amplification of the bioelectrical signal,
      obtention of its derivative in respect to time, automatic brightness control for
      both beams of the oscilloscope, and stability. The system includes a central
      measuring section which is a modified Tektronix oscilloscope type 565. Automatic
      control of brightness as a function of sweeping speed allows photographic
      recordings.

PMID- 1032261
TI  - Automatic microelectrode compensator (AMC).
AB  - A solid-state system designed for compensation of asymmetry potentials between
      microelectrodes, for bioelectric measurements, is described. Advantages over the
      manual compensator are the following: synchronic compensation of electrodes,
      application to automatized systems against aging effects in electordes, high
      speed, and elimination of general muisances of manual circuits. Besides, the
      system allows to measure digitally the polarization difference and resting
      membrane potential with precision of +/- 1 mV.

PMID- 1032262
TI  - Automatic silver-plater of electrodes. Reference silver-silver chloride
      electrodes.
AB  - The silver-plater developed for the preparation of silver-silver chloride
      electrodes attains constancy in electrochemical characteristics, circulating
      current during exactly identical periods with inverted polarity.

PMID- 1032263
TI  - Influence of sympathectomy on survival after coronary occlusion.

PMID- 1032264
TI  - The effect of adrenaline, tyramine and guanethidine on one-way step-up avoidance.

PMID- 1032265
TI  - Effect of diabetes on growth of mouse lymphoma P1798.

PMID- 1032266
TI  - [Immunology and Mycobacteriaceae].

PMID- 1032267
TI  - [Purification of kininogen II (LMW) from human plasma].
AB  - Plasma supernatant in which kallikrein has been activated and removed by glass
      powder whilst kininogen I (HMW) has been consumed by the activated kallikrein,
      was used for the preparation of kininogen II. It was purified by chromatography
      on DEAE-cellulose followed by gel filtration on G-200 Sephadex. The purification
      of kininogen II was assessed from determinations of the amount of kinin released
      (expressed as bradykinin) as measured on the isolated guinea pig ileum, using
      samples incubated with human salivary kallikrein or trypsin. A preparation of
      kininogen II containing an activity equivalent to 8 microgram Br/mg protein, was
      obtained. Salivary kallikrein released approximately three times more kinin from
      the substrate as compared to trypsin.

PMID- 1032268
TI  - [Purification and enzyme study of kininogens I and II from human plasma].
AB  - Kininogens I (HMW) and II (LMW) were isolated and partially purified from human
      plasma. The disappearance of kininogen I was prevented by the use of
      hexadimethrine bromide, which inhibits the activation of plasma prekallikrein.
      The two kininogens were separated by chromatography on DEAE-cellulose. Further
      purification of kininogen I and II was achieved by separate chromatographic steps
      of the partially purified kininogens on SP-Sephadex. The purification of the
      kininogens was controlled by incubation of the respective samples with different
      kininogenases: human plasma kallikrein, human salivary kallikrein and trypsin. As
      determined by gel filtration, a molecular weight of 250 000 daltons was found for
      kininogen I (HMW) and 48 000 daltons for kininogen II (LMW).

PMID- 1032269
TI  - Metabolic responses to catecholamines.
AB  - Isoproterenol and propranolol, in a single dose, caused hyperglycemia after 15
      and 30 min, either in the conscious rat or in the anesthetized dog. In this
      latter species no modifications of the serum potassium were observed. Adrenaline,
      5 microgram/kg, iv provoked hyperglycemia at the same intervals and hyperkalemia
      at min 1st and 2nd with further hypokalemia until 90 min. The beta-adrenergic
      blocker, sotalol, 5 mg/kg, iv, administered prior to adrenaline suppressed the
      increase in glycemia and the late decrease in serum potassium, but not the early
      hyperkalemia. In the isolated hind limb of the dog the intra femoral artery
      administration of adrenaline, 3 microgram/kg, produced similar hyperglycemia
      either in the artery or in the femoral vein, starting from the 15 min.
      Contrarily, the serum concentration of potassium was significantly less in the
      vein than in the artery at the 1st min. These findings suggest that different
      receptors are involved in the glucose and potassium response to adrenaline, and
      the skeletal muscle plays an important role in the regulation of the early
      hyperkalemia.

PMID- 1032270
TI  - Caudate-putamen and globus pallidus influences on a visceral reflex.
AB  - The electrical stimulation of the rostral striatum in rats has two different
      influences on bladder motility. Stimulus applied to the dorsomedial caudoputamen
      nucleus elicited vesical contractions and increased excitability of micturition
      reflex. Stimulation of the ventromedial caudoputamen suppressed detrusor
      contractions and increased the micturition threshold. Similar inhibitory effects
      were found by electrical stimulation of the globus pallidus. The possible
      mechanisms involved and the relationship with the clinical finding of bladder
      dysfunction in patients with extrapyramidal disease, are discussed in view of
      their anatomical and functional relationships to the vesicomotor centers.

PMID- 1032271
TI  - The effect of tranylcypromine on the body temperature of rabbits untreated and
      pretreated with para-chlorphenylalanine.

PMID- 1032272
TI  - Immunoreactive insulin in ischaemic heart disease.

PMID- 1032273
TI  - Effect of hypocalcic media on chemical sensitivity of toad sartorius muscle.
AB  - Membrane potential and spike activity were recorded through intracellular
      electrodes from toad sartorius muscles superfused in Krebs solution. When this
      was replaced by a hypocalcic medium (1/20 of normal Krebs Ca2+ concentration),
      muscles showed extrajunctional sensitivity to acetylcholine, histamine and
      noradrenaline applied iontophoretically. Normal sensitivity was restored when
      muscles were bathed in normal calcium media. Changes in chemical excitability of
      the fibers immersed in hypocalcic solution were related to decreased input
      membrane resistance. These observations emphasize the role played by Ca2+ on
      electrical stability and chemical sensitivity of skeletal muscle membrane.

PMID- 1032274
TI  - Nodular thickening of peritubular basement membranes in diabetic kidneys.
AB  - A conspicious renal change associated with diabetes is the thickening of the
      basement membranes. This was generally considered diffuse and little attention
      was paid to its nodular character. In the present study of the nodules, their
      topo-optical reation, electron microscopic fine structure as well as their
      trypsin digestibility after periodic acid-sulphatation revealed their basement
      membrane character. The increased basophilia obtained by the aldehyde-bisulphite
      toluidine blue reaction indicated an increased amount of sugar components,
      whereas the decreased double refraction and the red polarization colours a
      decrease of the micellary arrangement. The change is mostly observed in
      diabetics; the specific localization around the Henle loops may refer eventual
      hyperosmolar effects, whereas the nodular character points to the role of local
      factors.

PMID- 1032275
TI  - Neonatal hepatitis: histological and differential diagnostic aspects.
AB  - The morphological pecularities of neonatal hepatitis are discussed on the basis
      of biopsy in 41 cases. The manifestations are similar to those of virus hepatitis
      in more advanced age, with certain quantitative and qualitative differences. The
      obligatory presence of multinucleated hepatic giant cells is denied, but a
      peculiar cell type with large bizarre nucleus was found pathognomic. The
      questions of differential diagnosis are discussed and the importance of liver
      biopsy is emphasized.

PMID- 1032276
TI  - Secondary structure of glycosaminoglycans.
AB  - It has been shown by X-ray diffraction and chiroptic spectroscopy that the
      glycosaminoglycans in connective tissue develop a helical structure; this induces
      the coordination of polycations and scleroproteins in their environment
      polycations and promotes or inhibites fibrillary aggregation. Analysis of the ORD
      and CD spectra of various glycosaminoglycans, as well as those of oversulphated
      and desulphated preparations allowed the following conclusions concerning the
      secondary structure. 1. For the helical structure of glycosaminoglycans a chain
      length of 120 to 150 A and the presence of at least one sulphate group per two
      disaccharides are required. The helical structure is not influenced by binding to
      the protein skeleton, e.g. in proteoglycans. 2. Chiroptical properties of the
      glycosaminoglycan--either in themselves, or if their methylene blue complexes are
      studied--are determined by the degree of their sulphatation. 3. The degree of
      sulphatation determines the secondary structure of the molecule and thus also its
      biological properties. Fibrillogenesis in vitro and probably also in vivo are
      determined by the strength of the bond between collagen and glycosaminoglycans,
      in addition to the effect inducing the coordination. Structural analysis of the
      polysaccharides supports the coordinated fibrillary structure of GAG, as already
      assumed on the basis of polarization microscopic methods.

PMID- 1032277
TI  - Cell surface properties of L1210 leukaemia cells.
AB  - The surface properties of vincristine-colchicine sensitive and resistant L1210
      leukaemic cells have been studied using concanavalin A mediated agglutination
      assay as well as electron microscopic visualization of concanavalin A receptors.
      3H-colchicine uptake by the sensitive and resistant lines has also been compared.
      The resistant L1210 leukaemic cells proved less agglutinable than the sensitive
      ones at the same concanavalin A concentration. Previous treatments with either
      colchicine, vincristine or chlorpromazine caused a marked decrease in the
      agglutinability of the sensitive L1210 leukaemic cells, while agglutination of
      the resistant ones was lowered slightly by the same treatments. The 3H-colchicine
      uptake of the sensitive cells was three times higher than that of the resistant
      ones.

PMID- 1032278
TI  - Bioassay of blood-born tumour cells on in vivo and in vitro systems.
AB  - Viability and biological integrity of tumour cells circulating in the blood were
      studied in an experimental system using bioassay methods. Results of subcutaneous
      and intravenous retransplantation as well as explantation of the blood obtained
      from tumour-bearing animals previously receiving intravenous inoculation of
      tumour cell suspension (Yoshida sarcoma, Walker 256 carcinosarcoma and DMBA
      induced myeloid ascitic leukaemia), revealed that the tumour cells detected in
      the blood are not only viable at the time of their transportation in the blood
      stream but are also in possession of biologic potentials to proliferate and
      establish metastatic growths in organs.

PMID- 1032279
TI  - Infantile and juvenile cirrhosis of the liver.
AB  - In 14 years necropsy material 12 cases of infantile and 2 of juvenile liver
      cirrhosis occurred. In early infancy, diffuse cirrhosis is the most
      characteristic, whereas in more advanced age cirrhosis of irregular type is more
      frequent. The posthepatitic, secondary biliary, metabolic and cryptogenic
      cirrhoses are discussed from aetiological aspects.

PMID- 1032280
TI  - The role of heterogeneity of tumour cell populations in biological activity and
      sensitivity to chemotherapeutics.
AB  - The biological activity of a rat ascites leukaemia subline isolated by isopycnic
      centrifugation was compared to that of the original tumour both in vivo and in
      vitro. The subline had different marker chromosomes, a longer cell cycle time and
      decreased sensitivity to vinblastine as compared to the original tumour.

PMID- 1032281
TI  - Examination of curettage material for the diagnosis of ectopic pregnancy.
AB  - The histological characteristics of curettage material are described which raise
      the suspicion of ectopic pregnancy. In the period 1966 to 1975, 464 surgically
      removed pregnant uterine tubes and in 143 patients curettage material was also
      examined. On the basis of the curettage material, the suspicion of ectopic
      pregnancy arose in 109 cases (76%). In 34 curettage materials (24%) no
      histological sign referring to ectopic pregnancy was detected. Thus in three
      fourth of cases examination of the endometrial specimen was of diagnostic value
      and indicated the necessity of surgery.

PMID- 1032282
TI  - A study of hyperlipidaemia induced by ascites tumours.
AB  - In mice four stages of hyperlipidaemia induced by Ehrlich ascites tumour could be
      distinguished. Hyperlipidaemia is characterized mainly by increased serum VLDL
      content accompanied by high triglyceride concentration. The only exception was
      the regressive stage III where the serum lipid level (VLDL) has temporarily
      decreased. From the results obtained with the simultaneous examination of the
      liver, mesenteric fat tissue, tumour cell and ascites plasma lipids, it may be
      concluded that the endogeneous fat mobilization induced by tumour cells via
      increased VLDL synthesis and secretion of liver will lead to hyperlipidaemia and
      to the total depletion of the lipid stores. Rapid and reversible fall in lipid
      level following the withdrawal of ascites fluid in tumorous animals demonstrated
      clearly the direct effect of the tumour cells on lipid-lipoprotein metabolism of
      the host organism.

PMID- 1032283
TI  - Basal cell carcinomas of the eyelid and the periorbital region.

PMID- 1032284
TI  - Pathology of human precanceroses. Skin, larynx and breast.

PMID- 1032285
TI  - Avian aldolases. II. Primary structure of fructose-1,6-diphosphate aldolase from
      Gallus gallus domesticus and Columba liver breast muscle.

PMID- 1032286
TI  - Clinical observations on erythrocyte sedimentation rate mixed with
      tuberculoproteins.

PMID- 1032287
TI  - A study on the cases with negative disc exploration.

PMID- 1032288
TI  - Gastroscopic and histologic studies on recurrence and intractability of gastric
      ulcer.

PMID- 1032289
TI  - Snail control and some significant control projects, review.

PMID- 1032290
TI  - Studies on the possiblilty of production of immunity against schistosomiasis in
      experimental animals.
AB  - In the present work antigenization with somatic and metabolic antigens of adult
      Schistosoma mansoni worms, their cercariae or eggs has been tried. The study of
      the immunoglobulin patterns in infected and vaccinated non infected mice showed
      increase in IgG in all animals, increase in IgM only in the infected and IgA was
      frequently increased in mice that received metabolic or egg antigens. As regards
      the degree of resistance of vaccinated animals to S. mansoni infection, 2 groups
      gave prominent results. 1st the group vaccinated with Schistosoma mansonmetabolic
      worm antigen in which we got: -- Reduction in the worm load. -- Delayed ovulation
      and reduction in the number of ova/24 hr stools and/g of liver tissue. -- The
      histopathological picture of the liver was the best. 2nd the group vaccinated
      with egg antigen: Although it showed delayed ovulation and reduction in the ova
      count per 4 hr stools and/g liver tissue, yet the histopathological picture was
      the worst showing the largest granulomata.

PMID- 1032291
TI  - Leucine aminopeptidase, Significance of serum elevation in bilharziasis.
AB  - Leucine aminopeptidase (LAP) activity and creatinine concentration was estimated
      in serum of twenty five normal adult subjects, twenty four cases with active
      urinary bilharziasis, eleven cases with active intestinal bilharziasis, ten cases
      with mixed bilharzial infection (urinary and intestinal), fourteen bilharzial
      cases with clinical hepato-splenomegaly of bilharzial etiology, thirteen
      bilharzial cases with clinical hepatosplenomegaly and ascites, and twelve cases
      with cancer bladder of bilharzial etiology. Significant elevation in the serum
      enzyme level was found in all bilharzial cases which generally ran parallel to
      the course of the disease, being more marked in hepatosplenomegalic cases than in
      cases which showed no clinical signs of liver or spleen involvement. However, it
      was observed that the enzyme level was lower ascitic than in nonascitic cases.
      For serum creatinine concentration, no significant variation from normal value
      was observed in the group of patients with active urinary, active intestinal,
      mixed infections of bilharziasis and bilharzial hepatosplenomegalic cases.
      However, a very highly significant decrease in serum creatinine concentration was
      observed in the group of patients with bilharzial hepatosplenomegaly and ascites.
      Serum LAP activity and creatinine concentration in the group of patients with
      cancer bladder of bilharzial etiology showed no statistical variation from normal
      values.

PMID- 1032292
TI  - Urinary leucine aminopeptidase in bilharziasis.
AB  - Leucine aminopeptidase activity and total protein concentration was estimated in
      the fresh early morning sample of urine of twenty five normal adult subjects,
      twenty four cases with active urinary bilharziasis, eleven cases with active
      intestinal bilharziasis, ten cases with mixed bilharzial infection (urinary and
      intestinal), fourteen bilharzial cases with clinical hepatosplenomegaly of
      bilharzial etiology, thirteen bilharzial cases with clinical hepatosplenomegaly
      and ascites, and twelve cases with cancer bladder of bilharzial etiology. It was
      found that there is a significant increase in LAP activity in the urine of all
      groups of patients studied. Again this increase ran parallel to the course of the
      disease in bilharzial cases. Urine protein concentration was found to be
      increased significantly in all groups of bilharzial cases studied with the
      highest value in urine of patients with cancer bladder of bilharzial etiology.
      However no direct correlation was found between urinary LAP level and protein
      concentration either within the individual cases or within the different groups.

PMID- 1032293
TI  - Chemical control of the sea lamprey: the addition of a chemical to the
      environment.
AB  - Construction of the Welland Canal enabled shipping to by-pass Niagara Falls and
      enter the upper Great Lakes and also eliminated the barrier to the entry to the
      lakes by the sea lamprey (Petromyzon marinus Linnaeus). Within forty years the
      commercial fisheries of the Great Lakes was almost eliminated by this parasitic
      cyclostome. A search for selective chemical control of the sea lamprey was
      undertaken in the 1950's and culminated with the discovery of TFM (3
      Trifluoromethyl-4-nitrophenol). At the request of the International Great Lakes
      Fishery Commission, the Bureau of Sport Fisheries and Wildlife undertook to
      assess the hazard of TFM to the aquatic ecosystem, to humans as well as to fish
      and wildlife. Studies were undertaken in Bureau laboratories as well as by
      contracts with university and private laboratories. Results of these studies to
      date indicate that this material is not subject to biomagnification and does not
      pose a hazard to man or the the environment.

PMID- 1032294
TI  - Recent chemical and biological studies on natural products at the Central Drug
      Research Institute, Lucknow.

PMID- 1032295
TI  - Long-lived radionuclides in food: 90Sr and 137Cs in the Israel diet.
AB  - Routine monitoring of Strontium-90 and Cesium-137 levels in the main classes of
      food consumed in Israel has been carried out for a number of years. Calculations
      have been made of the intake of these isotopes by various groups in the Israel
      population using Food Consumption Survey data made available by the Israel
      Central Bureau of Statistics. More detailed analyses have been carried out to
      calculate the exposure of groups selected on the basis of demographic, economic
      and family-size criteria. This was carried out in an attempt to detect "critical
      groups" in the population who might be overly exposed. Results of these data
      indicate that in the case of Israel the monitoring of a single food item such as
      milk or the extrapolation of local fallout data cannot be relied on to give an
      estimate of radionuclide exposure through food. The relation between high
      consumption groups and the intake of "average" consumers is discussed in detail
      and the use of the statistical models developed in these studies for the
      estimates of radionuclide exposure during periods of high fallout levels which
      occurred in the past and possible applications with regard to other environmental
      contaminants is discussed.

PMID- 1032296
TI  - Selenium content of some foodstuffs and other environmental samples in a
      mineralized area of Italy.
AB  - No data are available on Selenium concentration in the Italian environment in
      spite of its importance as an essential and toxic element. In order to get some
      information about the concentration and distribution of this element in the
      environment and in the food-chain, a survey has been made in the Monte Amiata
      area (Toscana, Italy). Such an area was selected for this study owing to its
      large mineralization due to many elements (e.g. Fe, Cu, Ag, Sb and particularly
      Hg). The selenium content has been determined by thermal neutron activaltion
      analysis and a large volume high-resolution Ge-Li gamma ray spectrometer
      connected on line to a DEC PDP 8/L computer. The instrumental method requires
      neither a chemical separation technique nor a pre-or post-concentration of
      Selenium. The Selenium concentration for wet weight in foodstuffs ranges between
      a value of 0.008 ppm in milk and a value of 0.2 ppm in chicken. The average Se
      intake for the population living in the area under investigation has been also
      estimated. A critical discussion of the data is reported together with a
      comparison with the Se concentration values referring to other countries.

PMID- 1032297
TI  - Bioaccumulation of 14C-DDT in a small pond.

PMID- 1032298
TI  - ECDIN, an EC data bank for environmental chemicals.
AB  - All environmentally relevant information is computer stored for each organic
      chemical manufactured in quantities above 1.000 tons per year (whether it is
      considered as potentially toxic or not), known toxic chemicals (independently of
      their production figures) and certain classes of inorganic chemicals. The main
      data fields ("attributes" for each chemical) are: 1. substance identification and
      physicochemical data; 2. production and use data; 3. handling, transportation,
      and disposal; 4. environmental involvement (breakdown under biotic and abiotic
      conditions, average concentrations in environmental matrices); 5. biological
      effects and toxicity; 6. protection standards, administrative and regulatory
      data. Structure and substructure codification permits screening for substances
      with similar structures and coupling to GC-MS-computer analysis units with full
      or approximative structure outputs. A pilot project has been started permitting
      queries via direct and inverted file. It will include all available information
      on a limited number of compounds (some 5.000) from different chemical and use
      classes. The further software development foresees automatic indexing, automatic
      encoding of formatted data, automatic query formulation and search on a
      probabilistic basis for natural-language source data. Easy data flow is ensured
      by a networking between the central unit at the EC research Centre in Ispra
      (Italy) and specialised national data centres (ECDIN = European Chemicals Data
      and Information Network).

PMID- 1032299
TI  - Multielement characterization of atmospheric aerosols by instrumental neutron
      activation analysis and X-ray fluorescence analysis.

PMID- 1032300
TI  - Radioisotope techniques in delineation of the environmental behavior of cadmium.
AB  - Radioisotope techniques are being developed and utilized at Oak Ridge National
      Laboratory (ORNL) for evaluating the environmental behavior of toxic elements
      such as cadmium in aquatic and terrestrial ecosystems. Tracer techniques using
      109Cd in microcosm, field plot, and stream systems are providing information on
      biogeochemical cycling and distribution of cadmium in the environment. Parameters
      being measured include adsorption capacity for cadmium in mineral soils and
      sediments; uptake rates of cadmium in various plant species from both soils and
      nutrient solutions as affected by pH, competing cations, and chemical form of
      cadmium; and distribution of cadmium in various components of both aquatic and
      terrestrial ecosystems following application of 109Cd to soil vegetation, or
      directly to streams. Food chain parameters being estimated with 109Cd include
      uptake, assimilation, and turnover by both aquatic and terrestrial organisms.
      Information obtained in these radiotracer studies is providing insight into the
      behavior of cadmium in aquatic and terrestrial ecosystems, especially transport
      rates of cadmium and potential biomagnification or dilution in food chains. The
      factors which influence the incorporation of cadmium into vegetative material as
      well as those affecting residence time in ecosystems have been identified. Use of
      109Cd also has permitted evaluation of a cadmium specific electrode as a tool for
      rapid assay of free cadmium ions in soil solutions.

PMID- 1032301
TI  - Global inputs and trends of chemical residues in the biosphere.

PMID- 1032302
TI  - Technology assessment on the use of pesticides.
AB  - The extensive use of pesticides in Japanese agriculture was studied as a problem
      oriented case of technology assessment with an aim to contribute to the
      establishment of appropriate procedures of assessing real and potential impacts
      which modern technologies have or may have on health, industries, economy,
      society and on the environment and to obtain clues to the development of safer
      use of pesticides. Direct and indirect impacts, both real and potential,
      favourable and adverse, were intended to identify and evaluate systematically and
      comprehensively as their cause and effect sequences were studied. Adverse impacts
      were divided into tradable and untradable categories, untradable adverse impacts
      were related mostly to human health. As to the evaluation of impacts, it was
      suggested that the size of area and population affected, irreversibility and
      controllability of the impact be considered. It was recognized as urgent and
      requisite to develop and establish a more efficient and satisfactory method of
      testing the safety of pesticides and their metabolites over a wider spectrum of
      organisms and with respect to newer aspects of toxicology as mutagenesis,
      teratogenesis and cancerogenesis.

PMID- 1032303
TI  - Biological control and environmental quality.

PMID- 1032304
TI  - Natural enemies as a control agent of pests and the environmental complexity from
      the theoretical and experimental points of view.

PMID- 1032305
TI  - New approaches: pheromones and related chemicals in some USDA insect control
      programs.

PMID- 1032306
TI  - Use and field application of pheromones in orchard pest management programs.
AB  - Pheromones are recognized as potentially valuable tools in orchard pest
      management. Their most immediate practical application is in pest monitoring to
      indicate the need for chemical control. In this role, they can have considerable
      impact in reduction of pesticide output.

PMID- 1032307
TI  - Approaches to insect control based on chemical ecology--case studies.
AB  - In this article two attempted approaches to control a stored product insect,
      azuki bean weevil, are discussed based on host selection study and oviposition
      ecology. The latter study indicated the presence of an oviposition marker, a new
      kind of pheromone, which was derived from the weevil and was lipid in nature, and
      suggested its possible use as an oviposition inhibitor.

PMID- 1032308
TI  - Embryological aspects of environmental toxicology: relation between environmental
      protection and the successful conservation of species in the view of experimental
      embryology.

PMID- 1032309
TI  - Modern science for future environment and social university youth activities.

PMID- 1032310
TI  - Experiments on the effect of carbon monoxide on aminolevulinic acid dehydrase
      (ALAD).
AB  - The inverse relationship between blood lead concentration and aminolevulinic acid
      dehydrase (ALAD) is well known. Recently, it has been suggested that a similar
      relationship exists between carboxyhemoglobin (COHb) and ALAD activity. This
      study was undertaken to examine more closely the possible effect of carbon
      monoxide on ALAD. Blood from 19 human volunteers was analyzed for both
      carboxyhemoglobin and ALAD activity. Smokers had significantly lower
      concentrations of ALAD than nonsmokers and a rise in carboxyhemoglobin
      concentration was assocaited with a fall in ALAD activity. The in vitro bubbling
      of carbon monoxide into human blood did not significantly effect ALAD activity.
      Four groups of rats (10 per group) wre exposed to carbon monoxide or dietary lead
      acetate according to the following design: (I) Control--no Pb or CO; (II) 500 ppm
      Pb acetate in diet; (III) 250 ppm CO four hours/day X 5 days/week X 4 weeks; (IV)
      Both Pb and CO. Analysis of the rat data showed a significant depression of ALAD
      by lead. The activity of ALAD in the rats exposed to CO was significantly
      increased suggesting the possibility of an adaptive phenomenon.

PMID- 1032311
TI  - Chyluria pathologenesis and diagnosis.

PMID- 1032312
TI  - Effect of glucose on the action of some anaesthetics.

PMID- 1032313
TI  - Hycanthone in experimental schistosomiasis studies on liver pathology in mice
      treated with one and two doses.

PMID- 1032314
TI  - Papillary carcinoma of the thyroid, pathological aspects in relation to surgical
      management.

PMID- 1032315
TI  - Evaluation of some parameters of lead exposure and possible correlation between
      them.

PMID- 1032316
TI  - Food additives.

PMID- 1032317
TI  - The effect of "thalamonal" on the electromyographic activity of the stomach.

PMID- 1032318
TI  - Serum and urinary immunochemical studies in primary nephrotic syndrome.

PMID- 1032319
TI  - Serum transaminases in late pregnancy and after labour.

PMID- 1032320
TI  - Treatment of lichen planus with bactrim.

PMID- 1032321
TI  - Subacute extradural haematoma.

PMID- 1032322
TI  - Personal concepts and trends in management of cancer breast.

PMID- 1032323
TI  - Sexual problems associated with infertility.

PMID- 1032324
TI  - Linkage study on dieldrin resistance and an inversion on the second chromosome of
      Anopheles stephensi.
AB  - In a study on the linkage between the gene for dieldrin resistance and an
      inversion on the second chromosome in Anopheles stephensi, the two factors were
      found to assort independently. As dieldrin resistance can be assigned either to
      the third chromosome, or to a position on the second chromosome more than 50
      cross-over units from the inversion.

PMID- 1032325
TI  - [New faunal and biological observations on ticks in Abruzzo].
AB  - Ticks collected during the years 1975-76 in Abruzzo (Prov. l'Aquila and Chieti)
      Italy are reported. The following species have been identified: Ixodes canisuga,
      Ixodes frontalis, Ixodes hexagonus, Ixodes ricinus, Dermacentor marginatus,
      Haemaphysalis sulcata, Rhipicephalus bursa, Rhipicephalus sanguineus, Hyalomma
      marginatum. New hosts are: Felis catus for Ixodes canisuga; Scolopax rusticola,
      Motacilla flava, Corvus cornix for Ixodes frontalis; Sciurus vulgaris for
      Haemaphysalis punctata; Garrulus glandarius for Haemaphysalis sulcata. For Italy
      the following records are new: hosts: Corvus frugilegus for Ixodes frontalis;
      Coturnix coturnix and Alauda arvensis for Haemaphysalis sulcata; immature stages:
      Ixodes canisuga on Vulpes vulpes; Ixodes frontalis on Turdus merula;
      Haemaphysalis punctata on Coturnix coturnix, Phasianus colchicus, Erinaceus
      europaeus, Lepus europaeus; Accordingly numerous species, hosts and seasonal
      records are new for Abruzzo.

PMID- 1032326
TI  - Hut entry and exit by Anopheles gambiae and Anopheles funestus in an unsprayed
      village near Kaduna in Northern Nigeria.
AB  - Hut entry and exit by An. gambiae and An. funestus were studied in an unsprayed
      village near Kaduna in Northern Nigeria. A high turn-over of indoor resting
      mosquitoes of all blood digestion stages was noted throughout the night. The
      behaviour of both species was similar. The entry pattern was more uniform than
      the exit which showed two distinct peaks around sunset and after midnight. Most
      of the daytime resting mosquitoes left the huts during the first hour after
      sunset, and therefore the mosquitoes escaping during the subsequent hours of the
      night were mainly those that had entered the same night and spent only a limited
      period inside the huts. The significance of the movement of mosquitoes is
      discussed in relation to entomological evaluation of the impact of residual
      insecticides.

PMID- 1032327
TI  - [Infection of mice with oral administration of trophozoites of Giardia muris].
AB  - For the last 9 years we have used Giardia muris for chemotherapy research,
      passing trophozoites scraped from the mouse small intestine into fresh mice, by
      gavage. More or less every trophozoite administered orally reproduces in the
      intestine, as shown by quantitative studies in groups of young, specific pathogen
      free mice, treated with 1, 3, 10, 30 or 100 Giardia each. After 7-9 days the
      number of protozoa in the intestine diminished somewhat, in the groups infected
      with the largest number of trophozoites.

PMID- 1032328
TI  - [A new species of Plagioporus (Caudotestis) tyrrhenicus sp.n. and its 2 new
      parasitologic findings in Blennius pavo Risso, 1810].
AB  - In a survey of the helminth parasites of Blennius pavo Risso, 1810 three
      different species of digenea were collected. Plagioporus (Caudotestis)
      tyrrhenicus sp.n. is described, figured and compared with other species of the
      subgenus Plagioporus (Caudotestis) Issaitchikov, 1928. Plagioporus (Caudotestis)
      tyrrhenicus differs from P. (Caudotestis) azurionis Yamaguti, 1951 in the
      position of cirrus sac, in sucker ratio and size of the eggs; from P.
      (Caudotestis) sinitzini Mueller, 1934 for extent of excretory bladder and size of
      the eggs; from P. (Caudotestis) synagris Yamaguti, 1952 for size of the pharynx
      and oesophagus, extent of the vitellaria and size of the eggs. Lepocreadium album
      (Stossich, 1890) Stossich, 1904 is redescribed, figured and recorded for the
      first time in Blennius pavo. Deretrema sp. is figured and recorded for the first
      time in the same host.

PMID- 1032329
TI  - [Protostrongylus (Protostrongylus) rufescens boevi, a new subspecies, parasite of
      the respiratory apparatus of chamois].
AB  - A nematode parasitic of bronchial system of Rupicapra rupicapra (chamois) of
      Parco Nazionale del Gran Paradiso (Italian Western Alps) is described and the
      name Protostrongylus (Protostrongylus) rufescens boevi subspecies nova, is
      proposed.

PMID- 1032330
TI  - [Natural galactogenic infestation of the foal by Strongyloides westeri].
AB  - Strongyloides westeri larvae transmission by mare milk in foals has been studied;
      the results show the importance of this route for parasite penetration.

PMID- 1032331
TI  - [Observations on the species Stefanskostrongylus soricis (Soltys, 1954)].
AB  - A short redescription of Stefanskostrongylus soricis (Soltys, 1954) parasite of
      Sorex minutus from Bialowieza forest (Poland) and Parco Nazionale Gran Paradiso
      (West Italian Alps) is given.

PMID- 1032332
TI  - Transmission patterns of onchocerciasis in southwest Ethiopia.
AB  - The three transmission patterns found till now in Ethiopia are described. The
      forest area contains ideal conditions for the breeding of Simulium, but the
      sparse human population makes the transmission rate low. Only a few people were
      found to be infected. The subsistence crop farming area is a less ideal habitat
      for the vector due to the scarcity of bush and shade. However the presence of a
      largest population can explain the slightly higher prevalence of the disease than
      in the forest. The coffee farming area is densely populated, rich in bush and
      shade, with heavy rainfall and numerous rivers. Here the number of Simulium and
      their chance to reach the infective stages, are considered to be high. A high
      prevalence of the disease was found in this zone.

PMID- 1032333
TI  - [Irregularity of spicules of the genus Spiculocaulus Schulz, Orlow and Kutass,
      1933].
AB  - The accurate measurement of the length of the spicules of 100 male specimens of a
      lung nematode belonging to a species of the genus Spiculocaulus collected from
      trachea and bronchi of chamois (Rupicapra rupicapra) of Parco Nazionale del Gran
      Paradiso--Italian Western Alps--shows that the spicules are constantley inequal:
      the left spicule is the longer. The original description of the species
      Spiculocaulus austriacus (Gebauer, 1932) found in trachea and bronchi of
      Rupicapra rupicapra from Austrian Alps state to the contrary that in this species
      spicules are equal in length. New investigations are necessary to establish if
      the species S. austriacus has to be redescribed for this important character or
      if our specimens belong to a new species.

PMID- 1032334
TI  - [Parasitic fauna of Salmo trutta L. of the Tirino river. I. Redescription of
      Dentitruncus truttae Sinzar, 1955 and considerations on the genus Dentitruncus
      Sinzar, 1955].
AB  - Dentitruncus truttae Sinzar, 1955 is redescribed and figured from specimens from
      Salmo truttae L. collected in the Tirino river (L'Aqula-Italy). The diagnosis of
      the genus Dentitruncus is completed and the characteristics separating
      Dentitruncus Sinzar, 1955 from Pseudorhadinorhynchus Achmerov e Drombrowskaja
      Achmerova, 1941 are discussed.

PMID- 1032335
TI  - [2 additions to the fauna of Siphonaptera of the continental Italy].

PMID- 1032336
TI  - [Influence of temperature and humidity on the reproductive efficiency of Ixodes
      ricinus (Linnaeus, 1758) and Hyalomma marginatum Koch, 1844 (Ixodoidea,
      Ixodidae)].
AB  - Laboratory studies have been carried out on two species of ticks, I. ricinus and
      H. marginatum, showing different seasonal activity and different geographical
      distribution in nature. The purpose of the present study has been to investigate
      the effect of different combinations of temperature and humidity on the
      oviposition of I. ricinus and H. marginatum. An index of reproduction efficiency
      (no. eggs/wt female), established to relate the capacity of the females to
      produce eggs to their body weight, has been calculated; for I. ricinus 5
      temperatures (18-20-25-27 and 30 degrees C) have been studied (Fig. 1), for H.
      marginatum 3 (25-30 and 32 degrees C) (Fig. 2) and for both species 2 R.H. (75
      95%). An optimal range of temperature, within which the value of such an index
      doesn't change, has been demonstrated for both species by statistical testing
      (Table 1). A critical weight value as the minimum engorged female weight required
      for egg deposition has been identified with the weight of first female which has
      laid eggs. This weight, different in each species, is influenced by temperature
      and humidity.

PMID- 1032337
TI  - The salivary gland chromosomes of Anopheles labranchiae Falleroni 1926.
AB  - The salivary gland chromosomes of Anopheles labranchiae Falleroni, 1926 are
      described and figured. A. labranchiae is the sibling species of the maculipennis
      complex most closely related to A. atroparvus and the map of A. labranchiae is
      generally comparable to that of A. atroparvus. The chromosomal areas which are
      asynaptic in the hybrids between the two species are also described.

PMID- 1032338
TI  - [Diagnosis and treatment of glomerulonephritis].

PMID- 1032339
TI  - [Serodiagnosis in chronic pyelonephritis].

PMID- 1032340
TI  - [Surgical treatment of kidney neoplasms].

PMID- 1032341
TI  - [The present and future of artificial organs].

PMID- 1032342
TI  - [Biopsy in the diagnosis of glomerulonephritis].

PMID- 1032343
TI  - [A method for the objective evaluation of the auditory threshold].

PMID- 1032344
TI  - [Perilymph viscosity as a function of temperature and noise stress].

PMID- 1032345
TI  - Prevention of cardiovascular disease: an urgent Canadian problem.

PMID- 1032346
TI  - The future is now.

PMID- 1032347
TI  - Depression after myocardial infarction.

PMID- 1032348
TI  - Propranolol therapy in the perioperative period.

PMID- 1032349
TI  - Fomites in vaginitis.

PMID- 1032350
TI  - Sudden death in asthma.

PMID- 1032351
TI  - Caffeine content of beverages as consumed.
AB  - Quantitative analysis of beverages prepared at home by staff of the Addiction
      Research Foundation revealed a lower and much more variable caffeine content of
      both tea and coffee than had been reported in earlier studies, most of which were
      based on analysis of laboratory-prepared beverages. Median caffeine concentration
      of 37 home-prepared samples of tea was 27 mg per cup (range, 8 to 91 mg); for 46
      coffee samples the median concentration was 74 mg per cup (range, 29 to 176 mg).
      If tea and coffee as drunk contain less caffeine than generally supposed, the
      potency of caffeine may be greater than commonly realized, as may the relative
      caffeine content of certain commercial preparations, including chocolate and
      colas. The substantial variation in caffeine content emphasizes the need to
      establish actual caffeine intake in clinical, epidemiologic and experimental
      investigations of caffeine effects.

PMID- 1032352
TI  - In vitro estrogen-binding by human breast carcinomas.
AB  - Patients whose breast carcinomas possess only low concentrations of a receptor
      molecule that binds estrogens with high affinity are unlikely to respond to
      hormonal manipulative therapy when the disease recurs. The estrogen-binding
      capacity of 106 breast carcinomas was measured by an in vitro method and was
      expressed per milligram wet weight and in some cases related to the concentration
      of deoxyribonucleic acid (DNA) of the tumours. The ability of tumors to bind 3H
      estradiol ranged from 0 to 1.3 fm/mg in pre- and perenopausal women, and from 0
      to 16.8 fm/mg in postmenopausal women. Menopausal status or serum concentrations
      of endogenous estrogen, or both, should therefore be considered when tumours are
      classified into low and high estrogen-binding capacity. It is not necessary to
      carry out Scatchard analysis for every tumour, and expressing estradiol binding
      on the basis of DNA concentration may be preferable to expressing in on a wet
      weight basis.

PMID- 1032353
TI  - Decreased anion gap associated with monoclonal and pseudomonoclonal gammopathy.
AB  - Nine patients with monoclonal and one with pseudomonoclonal gammopathy were found
      to have a decreased anion gap. Eight of the patients had multiple myeloma, one
      has plasma cell leukemia and one had chronic active hepatitis. In all of the the
      decreased anion gap was associated with an increased concentration of IgG greater
      than 5 g/dl.

PMID- 1032354
TI  - Technique evaluation of foster care in chronic psychiatric disorders.
AB  - Foster care received by 178 patients with chronic psychiatric disorders
      discharged from Hamilton Psychiatric Hospital in the years 1966 through 1969 was
      studied by technique evaluation. Residents were followed for 3 years by means of
      health records. The achievement of operational objectives of the program (Homes
      for Special Care) was compared with two types of outcome--emergency readmission
      to hospital and discharge to the community. Emergency readmission was associated
      with rural location of the foster home, inferior quality of the home operator and
      smaller size (i.e., fewer residents) of the home. Discharge to the community was
      more common among younger, female residents whose previous psychiatric
      hospitalization had been relatively brief. In general, prescription audit was not
      a fruitful way of evaluating quality of health care.

PMID- 1032355
TI  - New view offered of cause of postoperative sepsis.

PMID- 1032356
TI  - Carcinogens are not that common.

PMID- 1032357
TI  - Symposium reviews how geriatric patients are different.

PMID- 1032358
TI  - Ultrasound providing valuable information in pregnancy.

PMID- 1032359
TI  - Finding and helping the deprived child.

PMID- 1032360
TI  - PEI's best buy hospital registers no sale.

PMID- 1032361
TI  - [Shock and renal ultrastructure].

PMID- 1032362
TI  - [Effect of thyrocalcitonin on ulcers experimentally induced in the rat by
      corticosteroids].

PMID- 1032363
TI  - [Influence of diazoxide on the response of the rat exocrine pancreas
      cholecystokinin-pancreozymin].

PMID- 1032364
TI  - [Spondylolisthesis. Introduction to a topic].

PMID- 1032365
TI  - [Papillomatosis of the upper urinary tract (studies of 4 cases)].

PMID- 1032366
TI  - The value of esophagoscopy in patients with bilharzial hepatic fibrosis.

PMID- 1032367
TI  - Pharmacological evaluation of xanthinol nicotinate (complamin).

PMID- 1032368
TI  - A simple tube test for assessing antibiotic sensitivity of certain anaerobic
      bacteria.

PMID- 1032369
TI  - A new sensitive Schistoma antigen for the diagnosis of schistosomiasis by the
      intradermal test.

PMID- 1032370
TI  - Inhibitory effect of metformin on L-B-phenyl alanine-125 absorption in man.

PMID- 1032371
TI  - Effect of nicotinic acid on blood sugar, its character and possible mechanism of
      action.

PMID- 1032372
TI  - Assessment of serum copper level and ceruloplasmin activity in toxaemia of
      pregnancy.

PMID- 1032373
TI  - Plasma immunoreactive insulin (IRI) and glucose tolerance in bilharzial hepatic
      fibrosis.

PMID- 1032374
TI  - Anti-leucocyte and anti-platelet iso- and autoantibodies in leukemias and
      malignant lymphomas.

PMID- 1032375
TI  - The relation of seminal acid phosphatase to fertility.

PMID- 1032376
TI  - Diagnostic value of Hagens test in inferitility.

PMID- 1032377
TI  - The absent symphysis syndrome.

PMID- 1032378
TI  - Hemostasis in the Egyptian female in abortion with a case report.

PMID- 1032379
TI  - Evaluation of salivary electrolytes in digitalis toxicity.

PMID- 1032380
TI  - A method for electrophysiologic study of drug actions on the ciliary muscle "in
      vivo".

PMID- 1032381
TI  - Zinc in serum and urine of diabetics.

PMID- 1032382
TI  - An investigation on the decarboxylase activity of human and animal diphtheroids.

PMID- 1032383
TI  - Some presentations of asymptomatic urinary tract infection.

PMID- 1032384
TI  - Assessment of serum arginase activity in intestinal and hepatic schistosomiasis.

PMID- 1032385
TI  - Tinidazole therapy in lambliasis and amoebiasis.

PMID- 1032386
TI  - Thalamonal with local infiltration anaesthesia in plastic surgery.

PMID- 1032387
TI  - New concepts and trends in hand infection.

PMID- 1032388
TI  - Cryptogenic malignant melanoma of the head and neck.

PMID- 1032389
TI  - Effect of intravenous citanest on adrenaline-induced ventricular fibrillation
      during chloroform anaesthesia.

PMID- 1032390
TI  - Spotlights on the Rod Sketch Theory.

PMID- 1032391
TI  - Hearing, traumatic deafness: medicolegal implications.

PMID- 1032392
TI  - Health Maintenance Organizations (HMOs)--legal hazards.

PMID- 1032393
TI  - The advent of legal abortion and surgical abortion techniques.

PMID- 1032394
TI  - A medical "brief" in a malpractice case.

PMID- 1032395
TI  - Blood groups in bastardy, paternity, heredity and criminal cases.

PMID- 1032396
TI  - The high-low contract: a trial by chance.

PMID- 1032397
TI  - Analysis of neocortical electrical responses evoked by stimulation of various
      hypothalamic structures.
AB  - Evoked potentials (EPs) and extracellular unit activity were recorded in various
      parts of the neocortex of unanesthetized cats immobilized with succinylcholine.
      During hippocampal stimulation EPs of maximal amplitude are recorded in the
      anterior sigmoid gyrus with a latent period (LP) of 0.5-2.5 msec. The first
      component is a fast positive spike with a duration of about 1.5 msec. In the
      middle suprasylvian gyrus, hypothalamo-cortical (HC) EPs have a monophasic
      surface-negative configuration and are recorded after an LP of 2-6 msec. HC EPS
      in the anterior sigmoid gyrus can bind a rhythm of stimulation of up to 200
      pulses/sec and are characterized not only by high functional mobility, but also
      by the property of posttetanic potentiation. The main positive wave appears to a
      testing stimulus with an interval of 7-10 msec. Complete recovery of all
      components of HC EP takes place at an interval of 50-150 msec. In response to the
      conditioning stimulus a biphasic change in excitability of the neurons is
      observed in the association areas of the anterior sigmoid and middle suprasylvian
      gyri of the neocortex. The maximal number of responding neurons in the deep
      layers of the cortex discharges in the period of development of the initial spike
      and the main positive wave of the HC EP.

PMID- 1032398
TI  - Analysis of the role of central noradrenergic structures in memory trace recall.
AB  - During the reproduction of a conditioned passive avoidance response by albino
      rats and also during the action of a conditioning stimulus in animals trained by
      invariable reinforcement of the conditioning stimulus, a significant decrease was
      found in the noradrenalin content in nuclei of the limbic system and anterior
      hypothalamus compared with the control. In untrained animals, and also in trained
      animals subjected to repeated testing in the course of 4 days, the decrease in
      the noradrenalin content was less marked. Reproduction of the conditioned active
      avoidence response in a shuttle box did not induce changes in the noradrenalin
      content.

PMID- 1032399
TI  - Senile amyloidosis in schizophrenia.

PMID- 1032400
TI  - Diagnostic importance and possible mechanism of a dynamic characteristic of the
      EEG in brain tumors.

PMID- 1032401
TI  - The autonomic basis of certain forms of activity in local lesions of the limbico
      reticular complex (mathematical analysis of the cardiac rhythm).

PMID- 1032402
TI  - Interaction between peripheral motoneurons of antagonist muscles in normal
      subjects and spastic hemiparesis studied by the H-reflex method.

PMID- 1032403
TI  - Functional asymmetry of the cerebral hemispheres in clinical types of
      schizophrenia.

PMID- 1032404
TI  - Predicting the frequency of episodes of schizophrenia (results of an
      epidemiological investigation).

PMID- 1032405
TI  - Family formation by patients with schizophrenia and manic-depressive psychosis
      based on the results of an epidemiological study of birth rates.

PMID- 1032406
TI  - Dynamics of evoked potentials in the dog auditory cortex during the formation of
      goal-directed behavior after ablation of the medial geniculate bodies.

PMID- 1032407
TI  - Functional maturation of the visula cortex during prenatal development of the
      cat.

PMID- 1032408
TI  - Correlation between neocortical and hippocampal biopotentials in lobectomized
      dogs.

PMID- 1032409
TI  - Heterogeneity of the neuron membrane of Helix pomatia and its possible role in
      the organization of receptive fields.

PMID- 1032410
TI  - EEG patterns in children aged 6-7 years during formation of a complex motor
      visual skill.

PMID- 1032411
TI  - Comparison of the role of the first and second cortical somatosensory areas in
      the conditioned behavior of animals.

PMID- 1032412
TI  - The spleen function of trapping the aged erythrocytes.

PMID- 1032413
TI  - Changes in erythrocyte specific gravity and osmotic fragility due to exercise.

PMID- 1032414
TI  - Some properties of rapidly labelled ribonucleic acid associated with light
      ribonucleoprotein particles from young and adult rat brains.

PMID- 1032415
TI  - Diagnostic application of thyroid lymphography for nodular thyroid lesions.

PMID- 1032416
TI  - A long-term observation of the environmental conditions of a factory
      manufacturing lead arsenate as an insecticide (studies on lead arsenate
      poisoning, Part 1).

PMID- 1032417
TI  - Senile changes in the physical strength and the skin, and their relation to vital
      prognosis.

PMID- 1032418
TI  - Therapeutic spectrum of sulpiride, haloperidol and lithium: a graphic
      representation by clinical observation.

PMID- 1032419
TI  - Induction of an allergic gastritis in guinea pigs sensitized to 2, 4
      dinitrochlorobenzene--Experimental studies on gastritis from the viewpoint of
      contact allergy.

PMID- 1032420
TI  - [Clinical trial of a new drug combination in cervico-vaginitis of mixed
      etiology].

PMID- 1032421
TI  - [Iatrogenic amenorrhea following the use of estroprogestogens].

PMID- 1032422
TI  - [Dopamine in threatened premature labor and in placental insufficiency.
      Preliminary observations].

PMID- 1032423
TI  - [The greatest contribution to the physico-chemical constitution of the amniotic
      fluid for the development of the ovum is made by the hormonopoietic tissue of the
      uterus].

PMID- 1032424
TI  - [The sinusoidal tracing: significance and prognosis].

PMID- 1032425
TI  - [Urographic aspects of the pelvic ureter in total genital prolapse].

PMID- 1032426
TI  - [A case of association of adenocarcinoma of the endometrium and cystico
      papilliferous carcinoma of the ovary].

PMID- 1032427
TI  - [Study of the behavior of hepatic function and blood coagulation in the course of
      oral administration of an estroprogestogen in low dosage].

PMID- 1032428
TI  - [Statistical evaluation of some epidemiological data concerning hydatidiform
      mole].

PMID- 1032429
TI  - [Induction of labor with orally administered desamino-oxytocin].

PMID- 1032430
TI  - [Physical findings concerning the conductivity of the maternal ECG through the
      dead fetus in utero, using a direct cardiotocographic system].

PMID- 1032431
TI  - [Histopathogenetic aspects in a case of Fahr's disease (non arteriosclerotic
      calcinosis of the brain) (author's transl)].
AB  - The study of one case of non arteriosclerotic calcinosis of the brain (Fahr's
      Disease) gives an opportunity for a discussion on the main pathogenetic aspects
      of this syndrome. Some features of hypertrophy and hyperplasia of astrocytes
      contrast with the fair preservation of neurons. It is suggested that such
      condition should be considered as an "astroglial syndrome" in Seitelberg's
      terminology.

PMID- 1032432
TI  - [Sleep disturbances in a case of Morvan's chorea (author's transl)].
AB  - Six nocturnal polygraphic recordings were carried out in a young man with
      fibrillary chorea of Morvan, during the acute period of the disease. Sleep was
      remarkably fragmented by numerous and brief awakenings but the total sleep time
      fluctuated between 157 and 312 mins.; the sleep structure was altered by the
      almost total absence of stages 3,4 and REM. During the day, the subject had one
      or two periods of sleep (1-2 hours) and complained of being tired. The nocturnal
      awakenings were correlated by the patient with pain and burning dysaesthesiae of
      distal distribution that were more severe than those occurring during the day.
      The patient improved gradually, and five month later both sleep disturbances and
      other signs of disease had disappeared.

PMID- 1032433
TI  - [Alzheimer's disease. Histopathological and ultrastructural study of 6 cases
      (author's transl)].
AB  - Histologically Alzheimer's disease is chiefly characterized by senile plaques and
      neurofibrillary degenerations. Electron microscopy has clarified the basic
      morphological changes and has shed some light on the pathogenesis of the lesions.
      The senile plaque includes three components: neurites in various stages of
      degeneration, amyloid, and glial cells or processes. Degeneration of neurites is
      considered to represent the major change since it occurs before amyloid
      deposition, therefore playing a primary role in the development of the plaque:
      therefore the senile or neuritic plaque is the result of a neuronal disease, even
      though there is no evidence of perikarion injury. Neurofibrillary tangles are due
      to the accumulation in the neuronal cytoplasm of large clusters of abnormal
      neurotubules about 200 A diameter with periodic narrowings every 800 A (Twisted
      tubules). The nature and significance of the pathological material observed
      within the neurons are discussed.

PMID- 1032434
TI  - Intellectual development and school achievement of youths 12-17 years:
      demographic and socioeconomic factors.

PMID- 1032435
TI  - Histochemical study of lipid absorption in two teleost fishes.
AB  - Absorption of lipid in the different regions of the intestine of two teleost
      fishes has been studied histochemically at different time intervals of 4, 10 and
      20 h. All the three portions of the intestine have the absorptive capacity.
      However, it varies from one region to another. The lipid has been absorbed in the
      form of lipoid particles and lipoid goblets. It is also recorded here that some
      lipoid droplets are absorbed by pinocytosis across the brush border membrane. The
      lipid absorbed was localized in the brush border cells, in intercellular spaces
      of connective tissue, in submucosa, in between serosa and muscularis, in the
      lumen of blood capillaries and mesentric lymphatic vessels but was absent in
      muscularis and serosa.

PMID- 1032436
TI  - Studies on the oogonial cycle in Puntius ticto (Ham.) II. Formation of mature
      follicles.
AB  - During the formation of maturing oocyte and mature follicle most of the changes
      are observed in the ooplasm while nucleus gets reduced in size and finally
      vanishes in the ooplasm. Few of the nuclei migrate into the ooplasm (yolk
      nucleus) which is responsible for the yolk accumulation. The mature follicle is
      covered by the theca, granulosa and zona rediata.

PMID- 1032437
TI  - Ultrastructural observation on the rectal gills of Zygoptera larva.
AB  - The zygoptera larvae have tracheal gills. Both outer and inner epicuticles of
      damselfly larvae (Zygoptera) are pierced by pores of about 200...250 A thickness.
      The pores are distributed at a distance of about 500...600 A apart. Their endings
      are noticed upto the lower portion of exocuticle. The endocuticle is a big area
      in which the respiratory epithelium have flat apical and basal sides, plasma
      membrane is not folded. Glycogen granules are distributed in the cytoplasm and a
      few mitochondria are noticed. The tracheal brances and the cytoplasm of the
      respiratory epithelium come in contact with the epicuticle. The distribution of
      tracheoles, with surplus of tracheoles in a surface outside the hypodermis are
      close to the sub-cuticular area is found. The gills of Zygoptera appear to be
      merely respiratory organs having respiratory epithelium and the ions and water
      are resorbed from the modified rectal epithelium.

PMID- 1032438
TI  - Studies on the toxic effect of cadmium in the rat. I. Testicular changes induced
      by a single subcutaneous injection of cadmium chloride.
AB  - Adult male rats of Wistar strain were subcutaneously injected with a single dose
      of 0.025 mM CdCl2/kg body weight. The autopsies were performed 2 and 12 weeks
      post cadmium injection. Experimental animals showed a normal gain of body weight
      while a marked lowering of the testes weight was observed. The lowering of testes
      weight of cadmium treated rats occured mainly due to the necrosis of seminiferous
      tubules, volume of which is markedly lower if compared to intact control rats.
      After 2 weeks of experiment a marked enlargement of the interstitial gland of the
      testis occured while after 12 weeks the gland is markedly lower if compared to
      control rats and to rats studied 2 weeks post cadmium injection. Histochemical
      reactions for lactic, succinic, alpha-glycerophosphate and 3beta-hydroxy steroid
      dehydrogenases, NADH tetrazolium reductase, acid phosphatase and nonspecific
      esterases showed for irreversible necrotic changes of seminiferous tubules of
      cadmium treated rats while the damage to interstitial gland is only temporary.

PMID- 1032439
TI  - [Peculiar capillary convolution of the parietal pleura. III. Electron microscopy
      studies].
AB  - By means of electron microscopy and ultrahistochemical research it has been
      attempted to detail the structure and explain the function of the pleural tufts
      of the parietal pleura present in the ventral mediastinum of dogs. This led to
      the discovery that the varions forms present for the surface-enlarging pleura
      protusions in actuality exhibit corresponding morphological characteristics. As a
      special formation of the serous lamina of parietal pleura, they are covered by an
      occasionally incomplete mesothel unit. The parenchyma of these organs is
      compinsed of a macrophage-rich outer border zone and of a vessel-canying central
      zone. The experimental in vivo application of cationized ferritin in the pleura
      space clearly indicated a high resorptive metabolism of the mesothel and of the
      pluripotential mesenchym cells. The higher incidence of lymphoplasmatic cell
      forms in the proximity of the central vessels along with leucocytic cell
      infiltrations fulfill an immunocellular and phagocytic function. The structure of
      the cell population of the pleural tufts partaking on the resorption of matter
      out of the pleural space has been discussed in detail. The in vivo application of
      a cationized ferritin solution for the purpose of studying these resorptive
      processes has been critically judged.

PMID- 1032440
TI  - Ultrastructure of cells of proper gastric glands and their stroma in hemorrhagic
      shock in the rat.
AB  - Ultrastructural changes in the cells of the proper gastric glands and their
      stroma are biphasic in the hemorrhagic shock. First phase: "paralysis" of the
      capillary vessels with an oedema of their stroma, an intracellular oedema with
      hydropic degeneration of the parietal cells and a degranulation of the
      argentaffin and argentaffin-like cells. Second phase: ischemia of the gastric
      mucosa with ultrastructural features of: a) the increased secretion of the
      parietal cells, b) the degranulation of the chief gastric cells, c) the increased
      secretion processes in the mucous neck cells. These findings suggest that at last
      2 factors coincide in the pathogenesis of so-called stress gastric ulcerations:
      biphasic disturbances of blood circulation initially damage the gastric mucosa
      and are followed the digestive hyperactivity of the gastric juice finally
      resulting stress ulceration.

PMID- 1032441
TI  - Investigations on the ultrastructure of spermatozoa in chronic alcoholics.
AB  - The semen of 25 chronic alcoholics aged between 28 to 52 years was examined. The
      period of alcoholism amounted to 15 years the average being 12.3 years. In each
      person the semen was twice morphologically studied and the ultrastructure of
      spermatozoa was evaluated. Submicroscopic changes consisted mainly in the
      abnormal electron density of nuclear chromatin, altered structure of the acrosome
      and mitochondrial spiral, as well as in more rarely observed disturbed
      arrangement of fibrils of the axial filament complex. The hitherto non observed
      structure in human spermatozoon on the form of single, annular, "whorls" were
      described. The interdependance between ultrastructural changes of spermatozoa and
      fertility was discussed.

PMID- 1032442
TI  - Histomorphological and ultrastructural studies of a rat myocardium in
      experimental conditions.
AB  - A histomorphological and ultrastructural analysis of the adaptation reaction of
      the rat heart muscle during an early experimental alloxan diabetes has been
      carried out. Changes were observed in the orthomorphology of the ultrastructure
      which appeared as vesicular intercalated discs within the fasciae adherentes
      regions, as changes in the mitochondria, cell nucleus, myofibrills and in the
      sarcoplasmic reticulum with a simultaneous increase in the number of lipid
      bodies. The described alterations are dependent on the duration time of the
      experiment and on the disturbances in the entire and local system cellular
      metabolism.

PMID- 1032443
TI  - [Submicroscopic structure of collagen--a basis for the interpretation of
      corresponding polarization-optical and histochemical findings].
AB  - In view of new possibilities of acquiring relatively quantitative information
      about the molecular structure of collagenous fibres in histological section with
      the help of polarization and histochemical methods a survey is given of the most
      important aspects of the molecular structure of collagen in connection with the
      formation of "cross-links", giving due attention to the role of functional
      groups. These create the basis for interpreting morphological findings covering
      free amino-groups of lysin and hydroxylysin, guanidine groups of arginine and
      carboxyl groups of glutamic acid and asparaginic acid, gained by adding phenol or
      toluidine blue to collagenous fibres and by performing path difference
      measurements. References made to the applicability of this polarization
      histochemical method in clinical research and diagnostics, in gathering
      reproducible data on processes of development or growth and aging and
      pathological changes in collagen are intended to encourage wide use of this
      examination technique in practice.

PMID- 1032444
TI  - A morphological study of antibody transport in the transparent fluid flowing form
      the lymph-folds of the copulatory organ into the cloacal lumen of the cock
      (Gallus domesticus).
AB  - The lymph of the copulatory organ of the cock is produced mainly in the
      lymphobulbus phalli. The lymph fluid passes the secretory duct with its branching
      lymph capillaries and discharges into the lymph-fold. From here, it is released
      into the interstitial tissue through gaps of the lymph capillaries but also
      through the intercellular spaces between the endothelial cells of the lymph
      capillaries. A minor portion of the lymph is produced also in the lymph-fold from
      where it is transported in the interstitial tissue either by transfer vesicles of
      the circulatory blood capillaries or by pores and fenestrae of the transudatory
      blood capillaries. During the erection of the copulatory organ the lymph is
      pressed through the intercellular spaces of the epithelial covering the lymph
      fold which is cylindrical and multistratified in shape. From here, it reaches the
      cloacal lumen in the form of transparent fluid (TF). TF was collected by
      different methods. It contains immunoglobulins which arise from plasma cells of
      the lymph-fold. Juxtaluminally, the lymph passage takes place via zonulae
      pseudooccludentes. The epithelial covering secretes a mucoid substance which is
      added to the TF prior to its following the spermatic phase as the final fraction
      of the ejaculate. Plasma cells and lymphocytes migrate along the lymph flow in
      the intercellular spaces of the epithelial covering of the lymph-fold. After an
      experimental application of antigen the sub- and intraepithelial cells and
      lymphocytes increase in number with their portion of active cells exceeding the
      less active ones. The increase coincides with the increase in antibodies detected
      in the TF where they may cause a local immunisation.

PMID- 1032445
TI  - [The tabetic arthropathies. Study of a case of polyarthropathic tabes].

PMID- 1032446
TI  - Hypertension due to renal infarction. Report of a case of successful treatment.

PMID- 1032447
TI  - [Ozone treatment in root canal therapy. Introduction and general discussion].

PMID- 1032448
TI  - Congenital unilateral multicystic kidney.

PMID- 1032449
TI  - Traumatic rupture of the diaphragm.

PMID- 1032450
TI  - A comparative study of regression in Iranian schizophrenic and normal groups.

PMID- 1032451
TI  - Large aneurysm of the splenic artery.

PMID- 1032452
TI  - [Clinical study of 2 cases of Sturge-Weber-Krabbe syndrome].

PMID- 1032453
TI  - Alkaline phosphatase, total protein, protein-bound hexose and hexosamine changes
      in serum and wound fluids in surgically-induced subcutaneous wounds in buffalo
      calves.

PMID- 1032454
TI  - Morphological changes related to absorption of undigested protein in small
      intestinal epithelium cells of suckling pigs.

PMID- 1032455
TI  - The abomasal digestion in calves during development of the forestomachs.

PMID- 1032456
TI  - Bone mineral contents and serum alkaline phosphatase activity of healthy and hip
      dysplasic German sheepdogs.

PMID- 1032457
TI  - Histological study of coccidiosis caused in the silver carp and the bighead by
      Eimeria sinensis Chen, 1956.

PMID- 1032458
TI  - Alterations of the ruminal mucosa and its relation to the hepatic abscesses in
      bulls fed high energy and low fibre diets.

PMID- 1032459
TI  - Effect of heat treatment, pelleting and storage on the content of thiamine and
      other vitamin B compounds of some fodders.

PMID- 1032460
TI  - Evaluation of the local allergic (intrapalpebral) test for Aujeszky's disease
      virus infection in swine.

PMID- 1032461
TI  - Use of the injection preparation Dertil (ad Us. Vet.) in fasciolosis control.

PMID- 1032462
TI  - Droncit--a milestone in the control of Echinococcus granulosus in dogs.

PMID- 1032463
TI  - Influenza infectedness of captured and shot wild birds on north-eastern and south
      eastern parts of Hungary.

PMID- 1032464
TI  - Abortive Capillaria hepatica infection in the guinea pig.

PMID- 1032465
TI  - Studies on avian mycoplasmas by metabolic inhibition test.

PMID- 1032466
TI  - [Hepatomegalies and splenomegalies in the district of Huambo (Angola)].

PMID- 1032467
TI  - [Toxoplasmosis infection in subjects of Huambo, Angola].

PMID- 1032468
TI  - [Importance of maternal health in the development of the fetus and the newborn
      infant].

PMID- 1032469
TI  - [A new nitroimidazole derivative. Tinidazole for the treatment of giardiasis].

PMID- 1032470
TI  - [Cambendazole--a new substance for the treatment of strongyloidiasis].

PMID- 1032471
TI  - [Aedes (Stegomyia) vitattus Bigot (Diptera culicidae. Its occurrence in
      Portugal].

PMID- 1032472
TI  - [Arterial hypertension in the African Negroe: epidemiological and clinical
      aspects].

PMID- 1032473
TI  - [Treatment of intestinal helminthiases using a new drug combination: pyrantel
      pamoate and thiabendazole].

PMID- 1032474
TI  - [Public health colloquium at the University of Luanda. I. Demographic growth and
      health implications].

PMID- 1032475
TI  - [Evaluation of the disinfectant action of metepa on infected larvae of
      Ancylostoma caninum. I. In-vitro studies].

PMID- 1032476
TI  - [The anthropo-ecology of malnutrition among the Va'ndulu (Angola)].

PMID- 1032477
TI  - [Human Filariae].

PMID- 1032478
TI  - [Intestinal tuberculosis. Apropos of a case].

PMID- 1032480
TI  - [Analysis of components and concordance. An example].

PMID- 1032479
TI  - [Composition of essential amino acids in the diets of Alentejo workers and
      farmers of the West region].

PMID- 1032481
TI  - [Various statistical records on endemic cholera in Angola].

PMID- 1032482
TI  - Histochemical and electron microscopic observations on intraosseous ganglion.

PMID- 1032483
TI  - Studies on heteroglucides in human colostrum. I. Isolation and characterization
      of a new sialic acid-containing hexasaccharide, disialyl-lacto-N-tetraose, from
      human colostrum.

PMID- 1032484
TI  - Studies on heteroglucides in human colostrum. II. Isolation and characterization
      of five sialic acid-containing oligosaccharides from human colostrum.

PMID- 1032485
TI  - Studies on heteroglucides in human colostrum. III. Isolation and characterization
      of a new fucose-containing sialooligosaccharide from human colostrum.

PMID- 1032486
TI  - Studies on sialoglucides in human urine. I. Determination of sialoglucides with
      low molecular weights in human urine.

PMID- 1032487
TI  - Studies on sialoglucides in human urine. II. On the qualitative and quantitative
      changes of urinary sialoglucides under various conditions and an attempt to
      identify sialoglucides in blood.

PMID- 1032488
TI  - Two types of vestibulo-ocular reflex pattern caused by velocity and acceleration
      components of stimuli.

PMID- 1032489
TI  - Effects of eyelid closure on vestibular nystagmus.

PMID- 1032490
TI  - Electron microscopic observation on the outer hair cells and Deiters' cells of
      the rabbit.

PMID- 1032491
TI  - The comparative study of invertebrate glycosaminoglycans. I. Isolation of a novel
      acidic glycosaminoglycan, succinean sulfate, from mucus of the sanil, Succinea
      lauta Gould.

PMID- 1032492
TI  - The comparative study of invertebrate glycosaminoglycans. II. Structural studies
      of succinean sulfate.

PMID- 1032493
TI  - Unique skin-sensitization to own plasma.

PMID- 1032494
TI  - Hormonal changes after vasectomy.

PMID- 1032495
TI  - Exocrine hypoplasia of the pancreas--a case report.

PMID- 1032496
TI  - Pattern of assault.

PMID- 1032497
TI  - Plasma creatinine and creatinine clearance studies in normal individuals.

PMID- 1032498
TI  - Aetiological review of recurrent laryngeal nerve paralysis.

PMID- 1032499
TI  - Prevalence and pattern of drug abuse among Delhi University College students.

PMID- 1032500
TI  - Piperazine neurotoxicity and psychological reaction.

PMID- 1032501
TI  - Fracture of vertebral bodies due to accidental electric shock.

PMID- 1032502
TI  - Pulmonary candidiasis.

PMID- 1032503
TI  - Histoplasmosis.

PMID- 1032504
TI  - Angiolipoma of the labia majora.

PMID- 1032505
TI  - Herpes zoster-transverse myelitis.

PMID- 1032506
TI  - Role of IMA in nation building.

PMID- 1032507
TI  - Enzyme pattern in vascular diseases of brain.

PMID- 1032508
TI  - The association of leprosy and tuberculosis.

PMID- 1032509
TI  - Burns:.

PMID- 1032510
TI  - Pediatric dermatology: internal and external medicine.

PMID- 1032511
TI  - Toxic epidermal necrolysis - a review.

PMID- 1032512
TI  - Progeria in childhood with description of a new progeroid syndrome displaying
      gross Fabry-like changes in heart, great vessels and kidneys.

PMID- 1032513
TI  - Early signs of leprosy in children.
AB  - Leprosy in children is more frequent than generally thought. Diagnosis is not
      easily made because early signs of the diseases are overlooked. Statistic data
      from the Dermatologic Clinic Pascua of Mexico City reveal that early signs are
      cutaneous in 67%  of cases: hypochromic and anesthetic infiltration, nodules, and
      alopecia of eyebrows and eyelashes. Neurological symptoms such as anesthesis,
      facial paralysis, thickening of nerves and trophic problems are present in 19.3%
      of cases. The nose mucosae are congested in 9.2% of cases. Systemic
      manifestations may be present in 4% of cases. Examination of contacts living with
      lepromatous patients is stressed as the best way to discover the early signs of
      the disease. Dermatological consultation in  general and pediatric hospitals is
      also recommended. If diagnosis is delayed, leprosy can induce physical,
      psychological and social disabilitation of the patient.

PMID- 1032515
TI  - Lipodystrophia centrifugalis abdominalis infantilis.

PMID- 1032514
TI  - Familial annular erythema.

PMID- 1032516
TI  - Disseminate pigmented nevi and short stature.

PMID- 1032517
TI  - Congenital disseminate organoid tumors.

PMID- 1032518
TI  - Lymphomatoid papulosis. A model of immunoblastic reaction of the skin.
AB  - In 3 cases of lymphomatoid papulosis with few ulceronecrotic lesions and 5 with
      the classic features of pytiriasis lichenoides acuta with necrotic lesions, a
      considerable part of the cellular component of the infiltrate of the lesions
      showed the morphologic and cytochemical characteristics of the cells described as
      immunoblasts. The authors consider that the lymphomatoid papulosis could
      represent an immunoblastic response to an unknown antigen.

PMID- 1032520
TI  - Hemangiomas in the epidermal nevus syndrome.

PMID- 1032519
TI  - Congenital and non-congenital depigmentation.
AB  - The hypofunction of melanocytes results in congenital and noncongenital
      depigmentation. Congenital depigmentation can be further divided into two groups;
      the first is depigmentation caused by loss of melanization in premelanosomes
      represented by oculocutaneous albinism; the second group is congenital decrease
      of melanocytes represented by nevus dipigmentosus. In contrast, acquired
      progressive depigmentation represented by vitiligo vulgaris and Sutton's
      leukoderma is characterized by the loss of premelanosome synthesis. The
      pathogenesis of these three major types of melanogenic defects has been further
      discussed with the current clinical, biological and immunological view of
      melanogenesis.

PMID- 1032521
TI  - Collodion baby.
AB  - The study of 198 collodion babies, 29 personal cases and 169 from the literature
      was undertaken. The collodion membrane with spontaneously desquamate between the
      15th day and 3rd month of life. During the neonatal period one third of the
      infants die due to pulmonary complications or infection. The collodion membrane
      seems to have an increased permeability. The desquamation is followed by a
      relapse which leads to different keratinization disorders, most frequently
      nonbullous congenital ichthyosiform erythroderma.

PMID- 1032522
TI  - Organoid nevus.
AB  - The organoid nevus is a malformation of most of the normal tissue components in a
      strictly localized, smaller or larger area of skin, most commonly the scalp. It
      undergoes more or less predictable developmental changes in puberty and then
      remains stable, but is subject to secondary development of benign or
      semimalignant adnexal tumors in a significant percentage of cases. It may present
      clinically and histologically in a variety of forms, the most common ones being
      nevus sebaceus and nevus verrucosus. It may be associated with neurologic and
      skeletal abnormalities in the organoid nevus syndrome (Schimmelpenning-Feuerstein
      Mims). Total excision before adolescence is the treatment of choice.

PMID- 1032523
TI  - Giant cavernous haemangiomata.

PMID- 1032524
TI  - Urinary esterase activity of patients with atopic dermatitis and effects of t
      AMCHA on it.

PMID- 1032525
TI  - The skin and the heart in inherited disease.

PMID- 1032526
TI  - HLA antigens in atopic diseases.
AB  - The immunogenetical relationship among atopic diseases was investigated from the
      point of human major histocompatibility antigen. The relationship between IgE
      level and HLA antigen was also discussed. (1) Atopic dermatitis had no high
      frequency in HLA antigens. HLA-B12 in bronchial asthma and HLA-BW40 in allergic
      rhinitis were frequently found in the population study. (2) No HLA-BW15 was
      observed in these three diseases. The term called 'disease-resistant antigen' was
      proposed in this paper. (3) We considered that IgE level is not controled by HLA
      antigen.

PMID- 1032527
TI  - Light-sensitive dermatoses in children.

PMID- 1032528
TI  - [Evaluation of aids for the objective determination of ocular refraction based on
      a complex quality index].

PMID- 1032529
TI  - [Cystoscopes with fiber light guides].

PMID- 1032530
TI  - [Rectomicroscope and the its method of use].

PMID- 1032531
TI  - [Laryngoscopes with fiber light guides].

PMID- 1032532
TI  - [Optical tubes with fiber light guides for bronchoscopes].

PMID- 1032533
TI  - [Movie attachment for endoscopes].

PMID- 1032534
TI  - [High-power illuminator for light guide apparatus].

PMID- 1032535
TI  - [Electrode with fiber light guide for ophthalmological practice].

PMID- 1032536
TI  - [Fiber light guides and light flow filtration in devices for studying the tissues
      of the eye].

PMID- 1032537
TI  - [Comparative analysis of the characteristics of endoscopic optical relay
      systems].

PMID- 1032538
TI  - [Distortion correction in endoscopic optical systems].

PMID- 1032539
TI  - [Flexible biopsy esophagogastroduodenoscopes with fiber optics].

PMID- 1032540
TI  - [Use of the BESM-4 electronic computer in calculating the optical systems of
      medical devices].

PMID- 1032541
TI  - [Experimental study of the technical light characteristics of endoscopic optical
      systems].

PMID- 1032542
TI  - [Compensation for the image field curvature of an endoscopic optical system].

PMID- 1032543
TI  - [Cold sterilization methods for endoscopic devices].

PMID- 1032544
TI  - [Foundation for the medical equipment requirements of ophthalmological surgical
      instruments with fiber light guides].

PMID- 1032545
TI  - [Technology of fabricating the rod-like optical elements of endoscopes].

PMID- 1032546
TI  - [Characteristics of coating the optical parts of endoscopic devices].

PMID- 1032547
TI  - [Technology of fabricating interference filters for medical devices].

PMID- 1032548
TI  - [Standardization of portable electric power supply apparatus for medical optical
      devices and galvanocautery].

PMID- 1032549
TI  - [Standardization of medical endoscopes].

PMID- 1032550
TI  - [Devices for controlling miniature optical parts and testing optical apparatus].

PMID- 1032551
TI  - Contribution of the H reflex to the study of spasticity in adolescents.

PMID- 1032552
TI  - Anatomy of the lung and patterns of structural change in disease.

PMID- 1032554
TI  - Physiotherapy in obstructive airways diseases.

PMID- 1032553
TI  - Blood gases, rational oxygen therapy, air flow limitations.

PMID- 1032555
TI  - Education and training in the remedial professions.

PMID- 1032556
TI  - Thermoplastic collar survey.

PMID- 1032557
TI  - Sports medicine and the physiotherapist.

PMID- 1032558
TI  - St James' Hospital NHS Sports Medicine Clinic.

PMID- 1032559
TI  - Physiotherapists in sport: reflections from America.

PMID- 1032560
TI  - Sports medicine in school.

PMID- 1032561
TI  - Post-operative management of chronic achilles tendon pain in sportsmen.

PMID- 1032562
TI  - Testing for fitness.

PMID- 1032563
TI  - [Skin and rheumatoid arthritis].

PMID- 1032564
TI  - [Pathogenesis of the acute attack of gout. 1: solubility of monosodium urate ].

PMID- 1032565
TI  - [Changes of various blood parameters after an intravenous load of fructose in
      subjects with liver cirrhosis].

PMID- 1032566
TI  - [The Wissler-Fanconi syndrome. Nogographical classification and case
      contribution].

PMID- 1032567
TI  - [Clinical and psychopathological studies of a case of ochronotic arthropathy].

PMID- 1032568
TI  - The combined effect of propranolol with bethanidine or methyldopa in
      hypertension.

PMID- 1032569
TI  - Studies with a new cardioselective beta-blocker, metoprolol.
AB  - These studies indicate that the cardioselective beta-adrenergic blocking drug
      metoprolol might be expected to be at least as effective for the treatment of
      arterial hypertension as propranolol. The difference in effect on the peripheral
      vascular bed may be of importance when acute increase of the blood adrenaline
      level occur, as in severe anxiety states. Experience in long-term studies in all
      kinds of patients with raised arterial pressure has confirmed that metoprolol is
      an active antihypertensive agent of similar potency to other beta-blocking
      agents.

PMID- 1032570
TI  - Dissociation of the renin lowering and antihypertensive actions of propranolol.
AB  - Suppression of renin release by beta-adrenoceptor blocking drugs has been
      advocated as the prime blood pressure lowering mechanism of these agents. The
      present report casts doubt on this proposition in three ways. In the first study,
      involving 22 patients with borderline hypertension, patients with elevated plasma
      renin levels showed normalization of the blood pressure after pharmacological
      autonomic blockade with intravenous atropine, propranolol and phentolamine, the
      time course of the pressure fall being such as to exclude suppression of renin
      release as the antihypertensive mechanism. It is clear that in patients with mild
      hypertension and high plasma renin levels, the elevation of blood pressure is
      maintained by a neurogenic mechanism, the elevated plasma renin having no direct
      role in sustaining the higher blood pressure. In two additional studies involving
      21 patients in all with mild to moderately severe essential hypertension, to whom
      propranolol was administereed by mouth for 1--3 months, two findings were of
      interest:1) patients with low-renin essential hypertension showed a good
      antihypertensive response to propranolol, and 2) in some patients a dosedependent
      dissociation of the renin and blood pressure lowering action of propranolol could
      be demonstrated. These findings militate against the assumption that propranolol
      selectively lowers the blood pressure in "renin-dependent" hypertension, and
      strongly suggest that the antihypertensive action of this drug is not mediated by
      depression of plasma renin activity.

PMID- 1032571
TI  - [Effect of pindolol (Visken) on blood pressure and plasma renin activity in
      various forms of hypertension].
AB  - 1. In 20 of 20 patients (100%) with borderline hypertension Visken normalized the
      labile blood pressure. The high renin values after stimulation due to orthostasis
      and saluresis decreased significantly (p less than 0,01). 2. In 3 of 12 patients
      (25%) with hyporeninemic essential hypertension Visken alone normalized the blood
      pressure. The low renin values increased to the normal range. 3. In 4 of 18
      patients (22%) with normoreninemic essential hypertension Visken normalized the
      blood pressure. The normal renin values showed a decreasing tendency within the
      normal range. 4. In 4 of 10 patients (40%) with hyperreninemic essential
      hypertension Visken normalized the high blood pressure. In 3 of these patients
      renin decreased distinctly. 5. In 4 of 20 patients (20%) with renal hypertension
      a therapy with Visken alone normalized the blood pressure. In 3 patients the high
      renin values decreased to the normal range. 6. In the most other patients of the
      groups II to V the additional therapy with diuretics and reserpine normalized the
      blood pressure. In these cases the renin values showed different reactions
      corresponding to the different effects of betablocking agents, saluretics or
      reserpine on the plasma renin activity [7]. 7. It is interesting, that Visken not
      only suppresses high renin values (borderline hypertension [6], hyperreninemic
      essential hypertension), but also increases low renin values to the normal range
      in patients with hyporeninemic essential hypertension. Because in essential
      hypertension the high blood pressure per se may be responsible for the renin
      suppression [3,4], this increase of renin activity is possibly the consequence of
      blood pressure reduction, while the decrease of renin activity after Visken may
      be the cause of blood pressure reduction.

PMID- 1032572
TI  - The effect of prindolol on plasma noradrenaline, plasma renin and sodium
      potassium metabolism in patients with essential hypertension.
AB  - The chronic administration of prindolol in patients with essential hypertension
      resulted in the following: 1) a significant decrease in blood pressure and heart
      rate (with only the exception of the unchanged diastolic blood pressure after the
      stimulus of the seven-minute standing period), 2) a significant decrease of
      plasma noradrenaline concentrativn at rest and under orthostatic conditions, 3) a
      significant decrease of PRC at rest and an even more pronounced suppression of
      PRA after the stimulus of upright posture, 4)a significant decrease in total
      exchangeable sodium and 5) a concomitant significant increase in total body
      potassium even with an increase in body weight. These findings are not subject to
      easy interpretation. In particular, we cannot conclude which of the changed
      parameters plays the initial role in lowering blood pressure. A working
      hypothesis might presume that beta blocking agents inhibit central and/or
      peripheral sympathetic nervous activity. The results reduction in plasma renin
      concentration would in turn lead to a drop in aldosterone secretion rate
      indicated by the increase in potassium and decrease in sodiummour data would
      support such a sequence of events.

PMID- 1032573
TI  - [Hemodynamic long-term effects of a beta-receptor blockader (Pindolol) in primary
      essential hypertension].
AB  - 1. Pindolol lowers blood pressure both, immediately after administration by a
      reduction of cardiac output and heart rate and after long-term administration by
      reducing peripheral resistance. Cardiac index, initially decreased, reached the
      control value after 8 weeks of treatment. 2. The persistent reduction in heart
      rate and increase of the cardiac index during exercise after prolonged treatment
      together with the increase of right and left heart filling pressures seems to be
      due to augmentation of the Starling mechanism. The increase of the stroke volume
      at rest and during exercise diminished the blood-pressure lowering effect of the
      drug. 4. The exercise-induced increase of noradrenalin was abolished by acute
      administration of pindolol. After long-term treatment, however, we found a
      consistent and significant elevation of the plasma-catecholamines. This may
      reflect the development of heart failure [1], a tyramin- or cocain-like action of
      pindolol [2] or an indirect sympathicomimetic effect of this drug at low doses
      (10--15 mg/day orally ) [3]. 5. The elevation of plasma-noradrenalin reflects
      increased sympathetic tone and may be responsible for the increase in stroke
      volume and plasma renin activity observed by several authors. 6. Since there was
      no evidence for a hemodynamic mode of action, the lowering of blood rpessure by
      pindolol may be a central effect.

PMID- 1032574
TI  - [Hemodynamics following a 14-day propranolol therapy].

PMID- 1032575
TI  - [Clinicopharmacological studies with pindolol following intravenous and oral
      administration].
AB  - The beta-adrenoceptor blocking potency of pindolol after intravenous and after
      oral administration was compared in clinical pharmacological experiments in
      healthy volunteers. Equal doses of pindolol were aequiactive 75 min after
      intravenous and 2 h after oral administration on tachycardia due to isoprenaline
      infusions as well as on tachycardia due to exercise on the cycle ergometer. The
      results of this comparison of pharmacodynamic effects confirm the good enteral
      absorption reported in pharmacokinetic studies.

PMID- 1032576
TI  - A new method for rapid identification of influenza virus isolates.
AB  - With the use of bacteria sensitized by influenza virus strain-specific antisera,
      virus isolates can be identified rapidly. One drop of virus suspension is mixed
      with one drop of sensitized bacteria on a slide that is then agitated; reaction
      occurs within 10 minutes. The test is subtype-specific. The mehod is based on the
      fact that the cell wall of the Cowan type 1 strain of Staphylococcus aureus
      contains abundant quantities of an antigen, known as protein A, that reacts with
      the IgG molecule by binding it in such a manner that the antibody-combining sites
      remain free. If an antigen homologous to the antibody coated on the surface of
      the bacteria is added to the suspension of sensitized staphylococci,
      agglutination occurs.

PMID- 1032577
TI  - Management of maple syrup urine disease in Canada. Committee for improvement of
      Hereditary Disease Management.
AB  - Nine patients with classic maple syrup urine disease (MSUD) and four with variant
      forms are under care at five treatment centres in the network affiliated with the
      National Food Distribution Centre for the Treatment of Hereditary Metabolic
      Diseases (the "Food Bank"). Diagnosis was made by clinicians and not from mass
      screening programs. MSUD requires complex emergency treatment to prevent severe
      neurologic damage, but effective management is compatible with normal growth and
      development. Long-term treatment requires continuous monitoring of the response
      to diets restricted in branched-chain amino acids; semisynthetic diet products
      free of branched-chain amino acids, provided by the Food Bank, are essential.
      Centralized treatment programs reduce the cost of treatment and maximize the
      potential benefits. The leucine requirement for adequate somatic growth during
      infancy in MSUD was found to be 200 to 600 mg/d; this range is lower than that
      estimated for infants with an intact leucine catabolic outflow pathway. The
      requirements for isoleucine and valine in infancy were also found to be lower
      than published values for normal infants.

PMID- 1032578
TI  - Failure of acetylmethadol in treatment of narcotic addicts due to
      nonpharmacologic factors.
AB  - Acetylmethadol, a new narcotic substitute, has a longer duration of action than
      methadone. Seventeen subjects, former heroin users currently under methadone
      treatment, entered a study of the toxicity and efficacy of this drug. Only nine
      subjects completed the assessment phase of the study and began the acetylmethadol
      phase, and only one completed the 8-week study phase. Hence, no conclusions can
      be drawn about acetylmethadol's efficacy. The high attrition rate was unrelated
      to pharmacologic factors; the subjects were concerned that if this drug was
      effective there would be no methadone to take home and hence no opportunity to
      trade, sell or "play with" (that is, combine with other drugs) the latter. This
      study emphasizes the difficulty in determining the efficacy of specific drug
      treatments for opiate-dependent patients.

PMID- 1032579
TI  - Echocardiographic features of an unusual case of aortic valve endocarditis.
AB  - In a patient with aortic valve endocarditis a myocardial abscess, complete heart
      block and acute aortic regurgitation developed. Echocardiography gave evidence of
      large aortic valve vegetations, and at operation vegetations were found to have
      destroyed the right coronary cusp and part of the noncoronary cusp. Following
      surgery the patient recovered. Echocardiography may prove to be a useful
      noninvasive technique to aid in the timing of surgical therapy in patients with
      valvular vegetations.

PMID- 1032580
TI  - The golden years: CMA senior members look at the joys and problems of retirement.

PMID- 1032581
TI  - So you saved in an RRSP; how about spending it?

PMID- 1032582
TI  - The swine influenza vaccination program.

PMID- 1032583
TI  - Hereditary metabolic disease in Canada.

PMID- 1032584
TI  - The child with recurrent abdominal pain.

PMID- 1032585
TI  - Treatment of diabetes in psychogeriatric patients.

PMID- 1032586
TI  - Taeniasis in southern Alberta, 1894-1900.

PMID- 1032587
TI  - Health manpower statistics.

PMID- 1032588
TI  - Physician manpower requirements.

PMID- 1032589
TI  - Practical guidelines for assessing patients positive for hepatitis B surface
      antigen.
AB  - In assessing the patient the hepatitis B surface antigen (HBsAg) the physician
      must decide on the basis of physical findings, results of laboratory tests and
      biopsy, when indicated, whether the patient is an asymptomatic carrier or has
      acute or chronic hepatitis. Asymptomatic carriers of HBsAg must be educated in
      personal hygiene and the possibility of transmission, should not be allowed to
      donate blood or breast-feed and should not work with blood products for human use
      or pharmaceutical products designated for intravenous use. However, it is
      otherwise not necessary to advise these individuals to change their profession.

PMID- 1032590
TI  - Feasibility of routine testing for hepatitis B surface antigen in hospital
      employees and restriction of carriers.
AB  - In 1972-73, 48 hospital staff members were tested selectively for hepatitis B
      surface antigen (HBsAg); 4 (8.3%) were found to be HBsAg-positive. In 1974-75,
      1415 staff members were tested routinely before employment and at periodic health
      examination; 25 (1.8%) were found to be HBsAg-positive. Of the HBsAg-positive
      staff members 55.2% were Asians, this proportion being significantly (P less than
      0.05) greater than that of any other ethnic group, and 31.0% were southern
      Europeans. Nurses and laboratory technologists were the largest professional
      groups among the HBsAg-positive staff, each accounting for 20.7%. Our results
      indicate that it is impractical to carry out routine testing of hospital staff
      for HBsAg. Selective testing and restriction from work in their units is proposed
      for staff of the renal and peritoneal dialysis units, the emergency department
      and the intravenous team and dietary staff who handle food directly.

PMID- 1032591
TI  - Detection of core antibody in hepatitis B infection.
AB  - Hepatitis B core antigen (HBcAg) is found on the decoated Dane particle and on a
      morphologically similar particle detected mainly in the nucleus of hepatocytes of
      patients with hepatitis B. HBcAg prepared from the liver of a chimpanzee infected
      with hepatitis B virus was used to test human serum for core antibody (anti-HBc)
      by complement fixation. Anti-HBc was found in serum collected from patients with
      hepatitis B in both the acute and convalescent stages, from carriers of hepatitis
      B surface antigen (HBsAg) and from patients with chronic liver or renal disease
      who were carriers of HBsAg. It was not found in patients with hepatitis A or
      infectious mononucleosis, or in healthy persons who were not carriers of HBsAg.

PMID- 1032592
TI  - [The urinary excretion of pregnanediol during pregnancy determined by gas-liquid
      chromatography. I. Its evolution throughout the normal and pathological pregnancy
      (author's transl)].
AB  - Employing the technique described by Van Kampen and Anker, modified by Macarulla
      et al., 180 pregnant women have been studied (66 normals and 114 with different
      pathology: infertility, toxemia, diabetes, Rh isoinmunization, gemelar pregnancy
      and abortions), taking 319 determinations of pregnanediol in 24 hours urine
      samples. The analysis of the results show in normal pregnancy a progressive
      increase of the urinary pregnanediol from the beginning of gestation, this
      increase being more intense from the 20th week, reaching the maximum value in the
      37th week and from this point descending slowly. In patients with toxemia, the
      values of pregnanediol (in the majority of the cases) are decreased, while in
      pregnant women with antecedents of infertility are increased from the 36th week
      of pregnancy, although they had protective treatment from first months of
      pregnancy. No manifest deviations of urinary pregnanediol from the normal values
      exist in diabetic pregnant women, Rb isoinmunization or gemelar pregnancies. In
      aborted pregnancies the pregnanediol values are markedly decreased without a
      tendency to increase, contrary to the threats of abortion in full-term
      pregnancies.

PMID- 1032593
TI  - [The urinary excretion of pregnanediol during pregnancy determined by gas-liquid
      chromatography. II. Its relation with other parameters controling pregnancy
      (author's transl)].
AB  - The relation between the urinary pregnanediol determined by gas-liquid
      chromatography during pregnancy, with ultrasonic findings (biparietal diameter,
      thickness and echorrefringency of the placenta and the appreciated quantity of
      amniotic fluid), with biochemical parameters of control of pregnancy (beta
      glucoronidase, total and thermostable alkaline phosphatase), with amnioscopic
      findings, and with several studied parameters of the amniotic fluid by
      amniocentesis, were studied. A good relation exists with the parameters which
      denote placentary insufficiency and fetal risk (irregularity in the homogeneity
      of the placenta, elevation of the total and thermostable alkaline phosphatase,
      positive amnioscopy) and also with those that are related with fetal maturity
      (biparietal diameter, shake test, organge cells, creatinine in amniotic fluid,
      etc.). These results indicate that the determination of urinary pregnanediol can
      be one of the tests controlling the normal and pathological pregnancies, being
      useful in the detection of fetal risk and the diagnosis of the intrauterine fetal
      maturity.

PMID- 1032594
TI  - [The urinary excretion of pregnanediol during pregnancy determined by gas-liquid
      chromatography. III. Its relation with the obstetric results (author's transl)].
AB  - 269 determinations of urinary pregnanediol by gas-liquid chromatography were made
      in 140 patients during pregnancy. A relation between the pregnandioluria and the
      fetal results (adequacy of the weight to gestational age, Apgar score at one and
      five minutes of birth, umbilical artery blood PH and perinatal mortality) as well
      as the global evaluation of the placenta (macroscopic aspect, vascular index of
      Kawai et al. and Scott and Jordan index) was studied. The results show that in
      the cases with fetal pathology (small for date, depression, acidosis, perinatal
      death) as well as in the cases with placental pathology, the values of
      pregnanediol were significantly decreased from the first months of pregnancy,
      which indicate that the placental insufficiency is a very precoz chronic process
      and on the other hand, that the determination of urinary pregnanediol is a good
      method for its detection.

PMID- 1032595
TI  - Pituitary and adrenal influences upon spontaneous contractions of uterine horns
      isolated from ovariectomized or natural estrus rats.

PMID- 1032596
TI  - [BAME-Esterase activity in plasmas from blood of human placental interveillous
      space and umbilical cord vessels (author's transl)].
AB  - The authors studied an enzymatic activity (BAME-esterase) from human plasma,
      intimately related with the bradykinin release mechanisms. The optimal conditions
      of evaluation of the different plasmas were determined. Lately, the authors
      showed the results obtained with plasma from maternal peripheral blood, umbilical
      vessels blood and human placental intervillous space blood. It was concluded: 1.
      The study of enzymatic kinetics allows to establish a reaction time of 30
      minutes, and the enzymatic concentration contained within 0.5 ml. of plasma, as
      ideal parameters to determine the enzymatic activities into the different
      compartments. 2. In the cases studied, considered clinically normals, the
      enzymatic activity in plasma from the interveillous space, before and after the
      detachment of the placenta, was greater than in peripheral maternal and umbilical
      vessels bloods. The activity in umbilical artery plasma was greater than in
      umbilical vein and practically the same as in maternal plasma. 3. The esterase
      activity values into the compartments studied in pre-eclamptics, were similar to
      that found in the cases considered clinically normal.

PMID- 1032597
TI  - [The effect of androgens upon the differentiation of Cowper and Bartholin glands
      in rat fetuses (author's transl)].
AB  - In the present paper, a study is made of the normal structure shown in Bartholin
      and Cowper glands of 100 female fetuses and 100 male fetuses of Wistar rats at
      the end of gestation, with the structure of bulbouretral glands that formed in 70
      female fetuses of the same species and period of gestation masculinized by
      androgens. In relation to the Bartholin glands, whose bilateral sketch is
      constant in the fetuses, we can affirm that it shows significant differences of
      structure with regards to the sketch of the Cowper gland. On the opposite, the
      histologycal details of the latter, are entirely identical to those shown by the
      bulbouretral glands of the masculinized female fetuses, a fact which permits us
      to affirm that these are authentic Cowper glands, not only because of their
      position, but also because of their structure. This morphological data
      corresponds to a masculinization phenomenon and demonstrates that the Bartholin
      and Cowper glands are very sensitive to the effect of androgens during gestation.

PMID- 1032598
TI  - Serum luteinizing hormone follicle-stimulating hormone and prolactin in neonatal
      androgenized rats.
AB  - Serum levels of LH, FSH, Prolactin and Testosterone of 90 days old male rats
      androgenized soon after birth were determined by specific radioimmunoassay and
      were compared to untreated rats. LH and FSH levels were also determined in 90
      days old female rats neo-natally treated with testosterone and compared with
      normal diestrus rats. Androgenization of male rats significantly increased serum
      FSH and Prolactin levels without producing changes in plasma LH and testosterone
      concentrations. Similar increase in the FSH levels were found in androgenized
      female rats although plasma FSH concentrations were lower than in the male
      groups. These results obtained in male rats give an additional evidence that
      androgens acting in the first days of life are responsible of the higher levels
      of FSH and Prolactin that characterize the male or tonic pattern of gonadotrophin
      secretion.

PMID- 1032599
TI  - Oxidative and glicolytic metabolism of the frontal cortex (latero-frontal) and of
      the posterior cortex (latero-occipital) in relation with the sexual activity of
      the rat.
AB  - The authors of this paper have ascertained the glycolytic metabolism and the
      oxidative metabolism (intake of QO2), of the frontal and posterior cortex in
      female rats at different stages of the sexual cycle, as also in ovariectomized
      animals, by the intake of glucose and the production of lactates. The results
      indicate a statistically significant increase of the oxidative metabolism of the
      posterior cortex (latero-occipital) in the estrual and proestrual phases, in
      comparisons with the diestral phase. The frontal cortex (latero-frontal) did not
      show any significant difference; moreover, the glycolitic metabolism did not
      alter in any of the tissues under observation. These findings, seem to suggest
      possible participation of the posterior cortex (latero-occipital) on the
      regulation of sexual cycle of the rat. The activation of this cortex occurs
      through the preponderant imbricantion of the tri-carboxylic acid cycle.

PMID- 1032600
TI  - [Hystereoscopy with CO2. Technique, indications and contraindications (author's
      transl)].
AB  - The Hysteroscopy occupies again at the present time an important place among the
      gynecological explorations, since Lindeman introduced the use of controlled
      carbonic anhydride for the distension of the uterine cavity. This work studies
      the technique, indications and contra-indications as well as the value of the
      hysteroscopy in the first 80 explorations performed in the Gynecological
      Endoscopy Unit of the Centro de Estudios sobre Repoduccion Humana, from Barcelone
      (Spain). The results are commented and the reach of such endoscopic exploration
      is analised as routine technique of exploration in comparison to other
      exploratory techniques used in the study of uterine cavity.

PMID- 1032601
TI  - Human chorionic somatommamotropin (HCS) and pregnancy. Its relation with insulin.
AB  - Plasma HCS levels have been measured in normal and pathological pregnant women.
      In the normal group HCS levels increased from 6--8 weeks till 33-34 weeks and
      then felt significantly. HCS pattern in prediabetic and chemical diabetic
      pregnant women was similar to the normal group. However HCS levels in chemical
      diabetics were significantly higher during the first two trimesters. HCS levels
      increased in twin pregnancy, diminished in cases of eclampsia, hypertension,
      fetal growth retardation, mole and blighted ovum, and disappeared after
      intrauterine death. Nothing could be deduced from the obese and Rh
      isoimmunization groups. It is confirmed the value of HCS determination as an
      index of placental maturation. Also, insulin/HCS ratio may be of some aid in the
      study of carbohydrate intolerance in pregnancy.

PMID- 1032602
TI  - Teratoma of the ligamentum teres of the liver--a case report.

PMID- 1032603
TI  - A case of sideroblastic anemia.

PMID- 1032604
TI  - Ophthalmic angiography of malignant exophthalmos.

PMID- 1032605
TI  - A right subclavian artery as the last branch of the aortic arch.

PMID- 1032606
TI  - Incidence of peripheral arterial disease in patients of ischaemic heart disease
      in India.

PMID- 1032607
TI  - Preliminary report on electric evaluation of implanted pacemaker impulse by high
      speed oscilloscope.

PMID- 1032608
TI  - Perhexiline maleate in angina pectoris.

PMID- 1032609
TI  - Primary drug resistance in pulmonary tuberculosis.

PMID- 1032610
TI  - Therapeutic problems in the management of giant-sized mediastinal tumours.

PMID- 1032611
TI  - Percutaneous needle biopsy of the lung: diagnostic cogitability and inherent
      changes.

PMID- 1032612
TI  - Benign superior vena caval obstruction.

PMID- 1032613
TI  - Primary mesothelioma of the pericardium.

PMID- 1032614
TI  - Gastric allergy to rifampicin.

PMID- 1032615
TI  - Metronidazole in tropical eosinophillia: a phase II trial.

PMID- 1032616
TI  - The urban malaria problem in Tamilnadu State.

PMID- 1032617
TI  - Electrocardiographic changes in cerebrovascular accidents.

PMID- 1032618
TI  - Glycosaminoglycan content of normal human neonatal aorta.

PMID- 1032619
TI  - Surveiliance of intestinal amoebiasis and its treatment over a period of 3 years
      with metronidazole in an institution.

PMID- 1032620
TI  - Routine management of acute myocardial infarction.

PMID- 1032621
TI  - A study of serum iron and total iron binding capacity in hepatic cirrhosis.

PMID- 1032622
TI  - Iodide myxoedema simulating filariasis.

PMID- 1032623
TI  - [Metabolism of nucleic acids in testicles of adult rats deficient in vitamin A].
AB  - Avitaminosis A, applied on deficient rats receiving retinoic acid leads to an
      important decrease of thymidine incorporation in testicular DNA in vivo as well
      as in vitro. On the contrary uridine incorporation in RNA is considerably
      increased in vitro as well as in vivo. The function of ribosomes, as measured by
      the aggregation ability in the polysomes, is not altered by vitamin A deficiency.
      From these results one can say that the degenerescence of rat testicle is
      accompagnied by a decrease of DNA anabolism and a stimulation of RNA anabolism
      due to an increase of its catabolism (compensatory synthesis).

PMID- 1032624
TI  - Thiamine absorption in the rat. IV. Effects of caffeic acid (3,4
      dihydroxycinnamic acid) upon absorption and active transport of thiamine.
AB  - The effects upon thiamine absorption in-vitro and in-vivo by caffeic acid (a
      thiamine antagonist isolated from bracken) was studied, partly using 14C
      thiamine. It was again shown that caffeic acid reduced the quantity of thiochrome
      positive thiamine, dependant upon the concentration ratio caffeic acid/thiamine.
      Caffeic acid was able to pass across the intestinal wall and to exert its
      antithiamine effect in the serosal incubation fluid. When caffeic acid was
      present in the mucosal fluid the amount of thiochrome positive thiamine passed to
      the serosal side was diminished according to the mucosal caffeic acid
      concentration. In-vitro studies with 14C-thiamine revealed, however, that
      thiamine modified and turned into a thiochrome negative form by caffeic acid was
      absorbed similarly to unaffected thiamine. Active transport in-vitro of thiamine
      was significantly inhibited by the presence of caffeic acid.

PMID- 1032625
TI  - Antithiamine effect of coffee.

PMID- 1032626
TI  - Isolation, partial characterisation of antithiamine factor present in rice-bran
      and its effect on TPP-transketolase system and Staphylococcus aureus.
AB  - 1. A light yellow viscous oily antithiamine compound designated as Compound X was
      isolated from rice-bran and it was composed of three components--glucose, a
      yellow viscous oily substance (Fraction A) and a reddish brown amorphous
      substance (Fraction B). 2. 1 mg of Compound X inactivated 3.5 microgram of
      thiamine hydrochloride whereas 1 mg of Fraction A inactivated 26.5 microgram of
      thiamine hydrochloride. Fraction B had no antithiamine activity. 3. Fraction A
      was partially characterised as benzene nucleus with ortho dihydroxyl groups, one
      methyl group and a side chain containing hydroxyl and carboxylic acid groups. 4.
      Compound X as well as Fraction A inhibited the utilisation of ribose-5-phosphate
      by TPP-TK system of human erythrocyte hemolysate and the growth of Staphylococcus
      aureus was retarded by these compounds.

PMID- 1032627
TI  - Enzymatic microassay of pyridoxal-5'-phosphate using L-tyrosine apodecarboxylase
      and L-(1-14C) tyrosine.
AB  - A microassay for pyridoxal-5'-phosphate (PLP) is described, which incorporates
      both the enzymatic and radioisotopic techniques. The method is based upon the
      stoichiometric decarboxylation of L-(1-14C) tyrosine by L-tyrosine
      apodecarboxylase and PLP. This method is an extensive modification of the ones
      reported by us previously, the main features of this present method being the
      ease of preparation of the enzyme extract and the substrate, elimination of the
      preincubation period and shortening of the 14CO2-trapping step. The assay as
      described here is rapid, highly sensitive and specific.

PMID- 1032628
TI  - Erythrocyte glutathione metabolism in cobalt-deficient goats.
AB  - Cobalt deficiency was produced in goats by feeding them rhode grass hay. The
      deficient animals excreted increased amounts of methyl malonic acid in their
      urine, indicating a lack of vitamin B12. Erythrocyte reduced glutathione levels
      increased with the onset of anemia. There was a concomitant increase in the
      levels of erythrocyte glutathione reductase (GSSG NADPH Reductase) and
      glutathione peroxidase (GSH:H2O2 peroxidase)during deficiency. These results are
      compared with similar observations reported for vitamin B12 deficiency in humans.

PMID- 1032629
TI  - Ascorbic acid synthesis in certain guinea pigs.
AB  - Three guinea pigs fed a vitamin C-free diet manifested no symptoms of scurvy even
      after 4-8 months, normally increased in body weight and excreted quantities of
      ascorbic acid in urine far exceeding the total body pool of ascorbic acid. The
      course of healing subsequent to experimental trauma in one of these animals
      proved to be entirely normal and vitamin C concentration in its liver after 8
      months of a scorbutogenic regimen was found to be more than twice that in guinea
      pigs with a daily intake of 10 mg ascorbic acid. It is evident that certain
      guinea pigs are capable to synthesize ascorbic acid that fully covers the needs
      of the organism. However, the freqency of occurence of such guinea pigs appears
      to be extremely small.

PMID- 1032630
TI  - In vivo acylation of triglycerides and phosphoglycerides of liver subcellular
      fractions with palmitate-1-14C in rats fed vitamin A.
AB  - Incorporation of palmitate-1-14C into liver and its mitochondrial, and microsomal
      triglycerides and phosphoglycerides of rats fed 100000 I.U. of vitamin A for two
      days has been studied. Feeding of vitamin A significantly increased triglycerides
      in liver and its mitochondrial, microsomal and supernatant fractions as compared
      to the controls. A significant increase in total phospholipids and phosphatidyl
      choline was noted in liver mitochondrial and microsomal fractions of vitamin A
      fed rats. The incorporation of palmitate-1-14C (counts/min/liver) into
      triglycerides of liver mitochondrial, microsomal and supernatant fractions of
      vitamin A fed rats was significantly higher, whereas in phosphatidyl ethanolamine
      and phosphatidyl choline it was not significantly different from the controls.

PMID- 1032631
TI  - Effect of vitamin E deficiency on the level of superoxide dismutase, glutathione
      peroxidase, catalase and lipid peroxide in rat liver.
AB  - The activities of superoxide dismutase, glutathione peroxidase, catalase and
      xanthine oxidase were simultaneously studied in vitamin-E deficient and 
      supplemented rat liver and also measured the lipid peroxide content in liver. The
      lipid peroxide content of vitamin E-deficient rat liver, estimated by
      thiobarbituric acid, increased as compared with that of vitamin E-supplemented
      rat liver. No marked changes of activities of superoxide dismutase, glutathione
      peroxidase and catalase were observed, but the activity of xanthine oxidase which
      is strong superoxide generator increased in vitamin E-deficient rat liver. These
      results suggest that vitamin E prevents the accumulation of lipid peroxide, but
      not controls the level of peroxide scavenging system such as superoxide
      dismutase, glutathione peroxidase and catalase.

PMID- 1032632
TI  - Studies on the intestinal hydrolysis of tocopheryl esters.

PMID- 1032633
TI  - Vitamin E tolerance test in various gastrointestinal disorders.

PMID- 1032634
TI  - Dose - response relationship between warfarin and the metabolism of phylloquinone
      (vitamin K1) in man.

PMID- 1032635
TI  - Vitamin A and congenital malformations.

PMID- 1032636
TI  - The relation of impaired vitamin A and E tolerance to fat absorption in biliary
      diversion.
AB  - Eleven patients have been studied after cholecystectomy with exploration of the
      common bile duct (CBD) and insertion of a T tube for free biliary drainage. Prior
      to clamping the T tube no significant rise was seen above fasting serum vitamin A
      and E, or serum triglyceride levels after 6 of the patients had been given these
      substances in a liquid test meal. In addition no rise in fasting vitamin E levels
      was seen after 3 subjects had been loaded for 4 days with 0.5 g DL alpha
      tocopherol acetate/day. Faecal fat collections performed on 9 subjects indicated
      that over 70% of the ingested fat was absorbed. All these findings returned to
      normal when the T tube was clamped and the intraluminal flow of bile re
      established. We conclude that deficiency of bile may allow the absorption of fat
      in the absence of fat soluble vitamins.

PMID- 1032637
TI  - A method for the estimation of the vitamin A status of rats.

PMID- 1032638
TI  - Prolonged tests with retinoic acid as a source of vitamin A for rats.

PMID- 1032639
TI  - Distribution of H3-tocopherol in rat tissues and subcellular particles.

PMID- 1032640
TI  - Some aspects of steroidogenesis in the vitamin E deficient rat.

PMID- 1032641
TI  - Paracetamol hepatotoxicity and vitamin E.

PMID- 1032642
TI  - Vitamin E--selenium interactions.

PMID- 1032643
TI  - Lipoperoxides in organs of vitamin E deficient rats fed large amounts of highly
      unsaturated fats.
AB  - Rats were fed diets containing 10% cod liver oil with and without a supplement of
      tocopherol acetate for 32 weeks. The determination of peroxides in lipid extracts
      of adipose tissue, liver, heart and skeletal muscle by different methods was
      attempted. High amounts of peroxides were found only in adipose tissue of vitamin
      E deficient animals. Small values were found in other tissues of both groups. The
      problem whether the organs contain true lipoperoxides, or some other substances
      are responsible for the peroxide estimates, is discussed.

PMID- 1032644
TI  - Epidemiology of anthrax.

PMID- 1032646
TI  - Diabetes and infection.

PMID- 1032645
TI  - Chemoprophylaxis in chronic bronchitis.

PMID- 1032647
TI  - Experimental and clinical pharmacology of metampicillin in the biliary tract.

PMID- 1032648
TI  - Penetration of ampicillin into brain of rats with chronic renal failure.

PMID- 1032649
TI  - Scientific research freedom.

PMID- 1032650
TI  - Effect of micellization on rate of cupric-ion-promoted hydrolysis of dicarboxylic
      acid hemiesters.
AB  - The effect of micellar sodium lauryl sulfate on the rate of cupric-ion-promoted
      hydrolysis of some dicarboxylic acid hemiesters was investigated at pH 5, ionic
      strength 0.1 M, and 40, 45, and 50 degrees. The rate of cupric-ion-promoted
      hydrolysis of sodium n-decyloxalate in the micellar phase is about 50 times as
      fast as that in the bulk solution. The formation constant of the intermediate
      chelate complex, cupric decyl oxalate, was decreased in the micellar phase, while
      the rate of attack of hydroxide ion upon the chelate complex was increased. The
      overall rate increase is attributed to the increase in the entropy of activation
      for the reaction in the micellar phase. The rates of hydrolysis of sodium
      hydrocortisone 21-hemisuccinate and sodium hydrocortisone 21-hemi-(3,3
      dimethylglutarate) were unaffected by copper ion.

PMID- 1032651
TI  - Optimally predictive in vitro drug dissolution testing for in vivo
      bioavailability.

PMID- 1032652
TI  - Subnanogram assay for pilocarpine in biological fluids.
AB  - A method for the determination of pilocarpine was developed in which the
      imidazole ring of pilocarpine was acylated with heptafluorobutyric anhydride,
      using triethylamine as a catalyst. After cleanup, the pilocarpine derivative was
      analyzed using GLC with electron-capture detection. The limit of sensitivity was
      25-50 pg of pilocarpine, which had been subjected to the derivatization and
      cleanup procedures. The method was specific for pilocarpine, with the
      isopilocarpine derivative eluting prior to the pilocarpine derivative.

PMID- 1032653
TI  - Circular dichroism spectra of tetracycline complexes with Mg+2 and Ca+2.
AB  - The study of Ca+2 and Mg+2 complexes of tetracycline in buffered solution was
      undertaken to determine their stoichiometry and the chelation sites. Circular
      dichroism was used to follow complex formation. Modified tetracyclines, in which
      potential complexation sites were blocked, were used to determine the
      participation of particular sites in complexation. Calcium formed a 2:1 metal-ion
      to ligand complex, while the magnesium complex formed at a 1:1 ratio. Formation
      of the calcium complex involved addition of one metal ion to the C-10, C-11 site
      with subsequent addition of a second metal ion at the C-12, C-1 site. The
      magnesium chelate occurred at the C-11, C-12 beta-diketone site.

PMID- 1032654
TI  - N-Halo derivatives IV: Synthesis of low chlorine potential soft N-chloramine
      systems.
AB  - A number of low chlorine potential, soft N-chloramines containing nitrogen
      chlorine bonds of different polarity were prepared. These novel N-chloramine
      systems were based on derivatization of 2-amino-2-methyl-1-propanol.

PMID- 1032655
TI  - N-Halo derivatives VI: Microbiological and chemical evaluations of 3-chloro-2
      oxazolidinones.
AB  - Comparative antimicrobial activity of 3-chloro-2-oxazolidinone (I), 3-chloro-4
      methyl-2-oxazolidinone (II), 3-chloro-4,4-dimethyl-2-oxazolidinone (III), and N
      chlorosuccinimide (IV) was evaluated in aqueous buffers in the absence and
      presence of 5% horse serum. All four compounds had similar bactericidal activity
      in the absence of horse serum, but I and III had superior activity relative to IV
      when serum was present. Compound III was considerably more stable with respect ot
      loss of positive chlorine and bactericidal activity than I and II when stored in
      0.1 M sodium dihydrogen phosphate buffered to pH 7.0 at 40 degrees. Thus, III is
      potentially the most useful bactericidal agent of those evaluated. The chlorine
      potentials of I, II, and III, the rate constants for transfer of positive
      chlorine from I and III to morpholine in aqueous solutions, and the hydrolytic
      stabilities of I and III with respect to loss of positive chlorine were
      evaluated. These data, together with previously calculated data for IV, are used
      to rationalize the observed bactericidal activities.

PMID- 1032656
TI  - Effect of storage at specified temperature and humidity on properties of three
      directly compressible tablet formulations.
AB  - Direct compression tablets containing sodium starch glycolate, an alginate
      derivative, or povidone as a disintegrant, magnesium stearate as a lubricant,
      amaranth as a tracer, and dibasic calcium phosphate dihydrate as the matrix were
      stored for 30 days at 23 degrees and 75% relative humidity (R.H.), 45 degrees and
      75% R.H., and 65 degrees and 40% R.H. Samples were evaluated after 0, 10, 20, and
      30 days for size, hardness, and dissolution characteristics. Although no
      significant changes in the dimensions or hardness of the three tablet
      formulations, prepared at three different compaction pressures, were observed,
      the dissolution efficiency of the systems showed significant changes, some
      systems dissolving more rapidly and some more slowly after storage. In some
      cases, the changes were so substantial as to indicate the possibility of
      significant changes of the bioavailability of drugs formulated in such systems.
      The relevance of this work to the problem of evaluating aging effects on the
      physical properties of tablets is discussed.

PMID- 1032657
TI  - Disaggregation of compressed tablets.
AB  - Tablets of dibasic calcium phosphate containing varying proportions of intra- to
      extragranular maize starch were prepared at three compaction pressures. The
      surface area generated per tablet after 10 and 30 min of disintegration was
      measured with an automated counter by a new technique. The optimum starch
      combination that produced the maximum surface area in a tablet formulation was
      either 2.5% intra-12.5% extragranular or 15% intragranular starch alone. The
      distribution of starch did not affect the resultant strength of the tablets, and
      maximum generation of surface area was achieved by compacting the tablets at as
      low a pressure as practical.

PMID- 1032658
TI  - Dissolution characteristics and oral absorption of digitoxin and digoxin
      coprecipitates.
AB  - A marked increase in the dissolution rates od digitoxin and digoxin was attained
      by dispersing the drugs in two inert solid carriers, poloxamer 188 and
      deoxycholic acid. The 1 and 10% (w/w) drug-carrier solid dispersions were
      prepared by the solvent method. The former dissolved significantly faster than
      the latter. The oral administration of 10% (w/w) digitoxin-carrier coprecipitates
      to mice significantly increased toxicity. This observed increase is attributed to
      an increase in the rate and, possibly, the extent of oral absorption of the drug.
      Although a 10% coprecipitate of digoxin in both carriers showed an increase in
      the dissolution rate, no increase in oral toxicity was observed. X-ray
      diffraction patterns indicated that both digitoxin and deoxycholic acid undergo
      crystalline modifications due to treatment by the solvent, but the exact nature
      of the drug-carrier solid dispersions was not revealed.

PMID- 1032659
TI  - Electrochemical evidence for interaction between chlorpromazine hydrochloride and
      trifluoperazine hydrochloride and the flavin coenzymes.
AB  - Polarographic and chronopotentiometric methods were applied to study the effects
      of the phenothiazine tranquilizers chlorpromazine hydrochloride and
      trifluoperazine hydrochloride on the electrochemical behavior of the flavin
      coenzymes flavin mononucleotide and flavin adenine dinucleotide. The effects of
      the drugs were measured mainly by decreases in the diffusion currents, id,
      developed in the polarographic experiments and by a similar decrease in the
      chronopotentiometric constant, ior1/2, in the chronopotentiometric experiments
      when the coenzymes were reduced in the presence of the added drugs. The observed
      interference with the redox properties of the coenzymes could conceivably be
      related to the reported ability of the drugs to inhibit respiration and produce
      their tranquilizing effect.

PMID- 1032660
TI  - Fluorometric determination of trifluoromethyl-substituted 2,3-bis(4
      methoxyphenyl)indoles in biological materials.
AB  - Interest in the 5-, 6-, and 7-trifluoromethyl-substituted 2,3-bis(4
      methoxyphenyl)indoles as potent, orally active anti-inflammatory agents required
      a method for their determination in serum, urine, and feces to permit studies of
      their absorption, metabolism, and excretion. A simple, rapid, sensitive, and
      specific procedure was developed based on an ethyl acetate extraction of alkaline
      specimens and subsequent fluorometric analysis of ethanolic solutions of the
      extract residues. The method is sensitive to 0.1 microgram/ml, 0.5 microgram/ml,
      and 0.7 microgram/100 mg of these compounds in serum, urine, and feces,
      respectively. Overall mean recoveries and standard deviations of the 5-, 6-, and
      7-trifluoromethyl-substituted compounds from biological samples were 102.2 +/-
      3.0, 102.2 +/- 5.4, and 100.5 +/- 5.7%, respectively. The procedure was applied
      successfully to absorption studies with 2,3-bis(4-methoxyphenyl)-7
      (trifluoromethyl)indole in the dog.

PMID- 1032661
TI  - Effect of nonionic surfactants on percutaneous absorption of salicylic acid and
      sodium salicylate in the presence of dimethyl sulfoxide.
AB  - Fifteen nonionic surfactants, 10% (w/w), were each incorporated into white
      petrolatum USP ointment base containing 10% (w/w) salicylic acid or 11.6% (w/w)
      sodium salicylate with 10% (w/w) dimethyl sulfoxide. Percutaneous absorption was
      determined from blood salicylate levels in New Zealand white rabbits at regular
      intervals for 8 hr following application of the ointment. Percutaneous absorption
      of salicylic acid was increased significantly when sorbitan monopalmitate,
      sorbitan trioleate, poloxamer 231, poloxamer 182, polyoxyethylene 4 lauryl ether,
      polyoxyethylene 2 oleyl ether, or polyoxyl 8 stearate was added to the ointment
      containing dimethyl sulfoxide, salicylic acid, and white petrolatum. Percutaneous
      absorption of sodium salicylate was increased significantly when sorbitan
      monolaurate, sorbitan monopalmitate, or poloxamer 182 was added to the ointment
      containing dimethyl sulfoxide, sodium salicylate, and white petrolatum.

PMID- 1032662
TI  - Dissolution of two-component solids.
AB  - The dissolution rates of compressed two-component mixtures were investigated. A
      good correlation between the composition of the solid and its observed
      dissolution rate was demonstrated by regression analysis. A model for dissolution
      was applied to compressed mixtures of aspirin-salicylic acid, aspirin-phenacetin,
      phenacetin-caffeine, and aspirin and caffeine (the last mixture complexes in
      solution).

PMID- 1032663
TI  - Pharmacology of Quercus infectoria.
AB  - The galls of Quercus infectoria (Fagaceae), a commonly available plant in Iran,
      were studied pharmacologically. Two fractions were employed, a dried acetone
      treated methanol extract dissolved in water (Fraction A) and a subfraction
      prepared by chloroform-methanol extraction (Fraction B). Fraction A was active as
      an analgesic in rats and significantly reduced blood sugar levels in rabbits.
      Fraction B had CNS depressant activity. Data obtained with a treadmill indicated
      a decreased activity ratio by Fraction B, suggesting a possible interference in
      motor coordination. It potentiated the barbiturate sleeping time significantly
      without changing the onset time or the loss of the righting reflex. In addition,
      Fraction B exhibited a moderate antitremorine activity by causing a delay in the
      onset and a decrease in the severity of tremorine-induced tremors. The local
      anesthetic action of Fraction B was evident due to the complete blockade of the
      isolated frog sciatic nerve conduction.

PMID- 1032664
TI  - Potentiometric and spectral investigations of anhydrotetracycline and its metal
      ion complexes.
AB  - The interaction of various metal ions with anhydrotetracycline was investigated.
      A comparison of the UV-visible and fluorescence spectral characteristics of
      anhydrotetracycline and its metal-ion complexes with a number of modified
      anhydrotetracyclines in the presence of metal ions suggested that the C-11 oxygen
      was involved in metal-ion binding. Secondary binding was observed in the A-ring
      by circular dichroism when the primary site was blocked.

PMID- 1032665
TI  - Lipid-protein interactions: enhancement of enzyme activity of L-glutamic acid
      dehydrogenase by nonionic detergents.
AB  - Five nonionic detergents enhanced the activity of L-glutamic acid dehydrogenase
      [L-glutamate:nicotinamide adenine dinucleotide phosphate oxidoreductase
      (deaminating) (EC 1.4.1.3)]. These detergents activated the enzyme toward alpha
      ketoglutaric acid reduction, causing a decrease in the sensitivity of the enzyme
      to allosteric regulation by guanosine 5-triphosphate. There was also a diminution
      of the enhancing effect of the modifier adenosine 5-diphosphate on the enzyme's L
      glutamic acid dehydrogenase activity. These detergents may cause a conformational
      change in the enzyme, and this change could lead to an increase in the binding of
      the substrates for the alpha-ketoglutaric acid reduction. Accompanied with this
      conformational change would be a decrease in the binding of the modifier
      guanosine 5'-triphosphate, with no concomitant change in the binding of the
      adenosine 5'-diphosphate modifier.

PMID- 1032666
TI  - High-pressure liquid chromatographic determination of chlorphenesin carbamate and
      the beta-isomeric carbamate.
AB  - A high-pressure liquid chromatographic assay was developed for the determination
      of chlorphenesin carbamate and its beta-isomeric carbamate. A single 4-mm i.d. X
      30-cm column, prepacked with 10 micrometer fully porous silica gel particles, is
      used with 3% methanol in 50% water-saturated butyl chloride as the mobile phase.
      The procedure separates chlorphenesin carbamate from several possible impurities
      in addition to the beta-isomeric carbamate. The assay was applied to bulk drug
      and compressed tablets. The relative standard deviations for the assays of
      chlorphenesin carbamate and the beta-isomer are approximately 1 and 2%,
      respectively.

PMID- 1032667
TI  - Molecular connectivity VII: specific treatment of heteroatoms.
AB  - The molecular connective index, chi, initially designed for hydrocarbons, has
      been formally extended to molecules containing heteroatoms. The sigma value of
      the heteroatom is modified to take account of its number of attached hydrogen
      atoma, sigmaiv = Zv - hi. These values were successfully tested on boiling points
      and molar refractions. A table of sigmav values is presented for nitrogen,
      oxygen, fluorine, chlorine, bromine, and iodine in various bonding situations.

PMID- 1032668
TI  - Trace analysis of 2,4,5-trichlorophenoxyacetic acid, its glycineamide, and their
      alkaline hydrolyzable conjugates in mouse blood, urine, and feces.
AB  - Chemical methods were developed for the trace analysis of the herbicide 2,4,5
      trichlorophenoxyacetic acid, its glycineamide, and their alkaline hydrolyzable
      conjugates in mouse blood, urine, and feces. The salient elements of the methods
      are extraction of the free acids with benzene, methylation, cleanup on a silica
      gel column, and quantification via electron-capture GLC. Any unextracted
      conjugates remaining in the substrates are then subjected to alklaline
      hydrolysis, and the liberated 2,4,5-trichlorophenoxyacetic acid is assayed. Data
      are presented concerning recoveries of the compounds from the three spiked
      substrates. The utility of the procedures is illustrated by a preliminary
      pharmacolinetic study employing parallel electron-capture GLC and radioassays of
      the three substrates from mice injected with a single intravenous dose of 14C
      2,4,5-trichlorophenoxyacetic acid. GLC characteristics and partition values of
      the the compounds and hydrolysis of the glycineamide under various conditions
      also are discussed.

PMID- 1032669
TI  - Mechanistic studies on transcorneal permeation of pilocarpine.
AB  - The mechanism of corneal pilocarpine penetration was studied in the albino rabbit
      using radiochemical techniques. The apparent rate and extent of pilocarpine
      accumulation in the aqueous humor and the various cell layers of the cornea were
      determined for both intact and abraded eyes. For the first time, drug levels were
      monitored in the epithelium and stroma-endothelium of the intact cornea using a
      tissue-scraping technique. In addition, a new postinstillation rinsing method was
      devised to evaluate the rate of corneal uptake. The results demonstrate a dual
      role for the corneal epithelium, both as a barrier to drug penetration and as a
      reservoir for drug in the intact cornea. The transcorneal pilocarpine flux is
      slower than the data appear to indicate, and previous overestimates of the
      apparent absorption rate constant are due to parallel elimination processes
      occurring at the absorption site. Pharmacokinetic parameters were determined for
      each tissue to generate an overall mechanism for corneal permeation.

PMID- 1032670
TI  - Correlation of absorption of sulfamethazine boluses with dissolution using a new
      dissolution apparatus for veterinary tablets.
AB  - A rotating-basket apparatus for dissolution testing of veterinary bolus tablets
      was designed and constructed. Sulfamethazine boluses containing different
      disintegrating agents were evaluated in vitro and by blood level data following
      administration to cattle. The dissolution t50 and various pharmacokinetic
      parameters showed directly compressible starch and carboxymethylstarch to be the
      most effective disintegrants in the concentrations employed while magnesium
      aluminum silicate and microcrystalline cellulose were about equal but less
      effective than the previous disintegrants. A bolus formulation containing no
      disintegrant gave even less satisfactory results. A correlation was established
      between the dissolution t50 and the time to peak plasma level and also between
      the t50 and the area under the plasma-time curve for the first 36 hr.

PMID- 1032671
TI  - GLC determination of l-2-hydroxy-N-cyclopropylmethylmorphinan in plasma and
      urine.
AB  - A specific method was developed for the determination of l-2-hydroxy-N
      cyclopropylmethylmorphinan in plasma and urine by GLC, using flame-ionization
      detection. The method involves the extraction of the compound into ether from
      plasma or urine at pH 7.4, followed by back-extraction into 1 N HCl. The acid
      phase is ether washed and made alkaline, and the compound is reextracted into
      ether. The ether is evaporated to dryness, the residue is dissolved in methanol,
      and an aliquot is analyzed by GLC. The same method is applicalble to plasma and
      urine samples following deconjugation of the compound with glucuronidase
      sulfatase. The overall recovery is 93.1 +/- 9.4% SD) in the concentration range
      of 0.020-2.0 microgram/ml. The method was successfully applied to plasma and
      urine specimens obtained after administering single 25-mg oral doses to humans.

PMID- 1032672
TI  - Determination of cyanocobalamin by thermal decomposition of the cyano group using
      an ion-selective electrode.
AB  - A method for the simultaneous determination of cyanocobalamin, cobinamide (Factor
      B), and hydroxocobalamin in the solid state is described. The method is based on
      heating at 120 degrees for cobinamide and at 140-145 degrees for cyanocobalamin
      (15-20 min). The cyano content in the sample is distilled as hydrocyanic acid,
      trapped in 0.1 M potassium nitrate at pH 12-13, and determined by means of the
      cyanide ion-selective electrode. The error of this method, statistically
      established, does not exceed +/-3%.

PMID- 1032673
TI  - Steric inhibition of conjugation in lowest excited singlet state of 9-anthramide
      by hydrogen bond donor solvents: role of solvent in chemical structure.
AB  - 9-Anthramide has electronic absorption and fluorescence spectra that, in water,
      are similar to those of anthracene. This result is attributed to steric hindrance
      of the 9-carboxamido group with the peri-hydrogen atoms in the 1- and 8-positions
      of the anthracene ring. However, in aprotic solvents, although the absorption
      spectrum of 9-anthramide is anthracene-like, its fluorescence spectrum is red
      shifted and structureless. This finding is attributed to excited-state rotation
      of the 9-carboxamido group into coplanarity with the anthracene ring and
      indicates that, in water, the hydrogen-bonded solvent cage affects the steric
      inhibition of conjugation in excited 9-anthramide. These findings suggest that
      studies of structure and reactivity of drugs in nonaqueous or solid matrixes are
      probably of only limited value, since in the strongly interacting aqueous media
      the aqueous solvent cage plays a substantial role in determining molecular
      structure and reactivity.

PMID- 1032674
TI  - Effect of variation in compaction force on properties of six direct compression
      tablet formulations.
AB  - The effect of variation in compaction force on six direct compression tablet
      matrixes was investigated. An instrumented tablet press allowed direct
      measurement of applied and ejection forces. Hardness, apparent tablet density,
      and disintegration times also were determined. The disintegration time of spray
      dried lactose tablets was essentially independent of compaction force. However,
      in the other systems investigated, the properties studied showed varying types of
      dependence on compaction pressure. A direct compression formula was developed and
      exhibits a decrease in disintegration time as compaction force is increased.

PMID- 1032675
TI  - Influence of steroids and stress on toxicity and disposition of
      tetraethylammonium bromide.
AB  - In female rats, pretreatment with dexamethasone acetate or triamcinolone reduced
      the toxicity and plasma concentrations of tetraethylammonium bromide while
      increasing its level in urine. Pretreatment with corticosterone acetate or
      pregnenolone-16alpha-carbonitrile shared none of these effects. Although
      starvation or restraint neither diminished the tetraethylammonium bromide
      concentrations in plasma nor accelerated its urinary excretion, its toxicity was
      diminished by the stress induced with spinal cord lesions, heat, cold,
      hydrocortisone, or reserpine as well as starvation or restraint. The protection
      offered against the toxicant by stress and by the potent glucocorticoids seemed
      to be mediated, at least partly, via different mechanisms. Stress-induced
      resistance to tetraethylammonium bromide could not be attributed to elevated
      plasma corticosterone levels, whereas glucocorticoid-induced resistance could be
      partially ascribed to increased urinary excretion of the toxicant.

PMID- 1032676
TI  - Determination of the nonnutritive sweetener sodium cyclopentylsulfamate and three
      of its metabolites, cyclopentylamine, cyclopentanone, and cyclopentanol, in urine
      of rats and rabbits.
AB  - The nonnutritive sweetener sodium cyclopentylsulfamate was fed to Wistar albino
      rats and New Zealand White rabbits. Urine was collected for 3 days after feeding,
      combined, and examined for the metabolites cyclopentylamine, cyclopentanone, and
      cyclopentanol and for sodium cyclopentylsulfamate was assayed by hydrolysis in
      acidified dioxane-water and subsequent measurement of the absorbance of the
      product formed (lambdamax = 490 nm) by the liberated amine with p-benzoquinone.
      The average conversion to cyclopentylamine, cyclopentanone, and cyclopentanol was
      0.103, 0.171, and 0.054% in the rabbit and 0.057, 0.016, and 0.008% in the rat,
      respectively.

PMID- 1032677
TI  - The nature of immunity.

PMID- 1032678
TI  - Effect of pentagastrin on blood sugar, serum amylase, lipase and calcium in
      normal control and duodenal ulcer subjects.

PMID- 1032679
TI  - A comparative study of central nervous system depressant effects of some of the
      disubstituted piperazine compounds--part I.

PMID- 1032680
TI  - Factors influencing the age of menarche.

PMID- 1032682
TI  - Language of the English-speaking coloured child.

PMID- 1032681
TI  - Serum lipoproteins, phospholopid and cholesterol levels in normal children.

PMID- 1032683
TI  - A therapy programme for pre-school language impaired children.

PMID- 1032684
TI  - Mass generalised learning applied to the problem of carry-over in articulation
      therapy.

PMID- 1032685
TI  - [Neuro-evolutional and neurophysiologic approach to the diagnosis and treatment
      acquired dysarthria].

PMID- 1032686
TI  - Articulation in apraxia of speech.

PMID- 1032687
TI  - [Diagnosis of cluttering as a psychoneurologic disorder].

PMID- 1032688
TI  - A filtered speech test for an aging population.

PMID- 1032689
TI  - A comparison of the SISI and the stapedius reflex test in the differential
      diagnosis of choclear pathology.

PMID- 1032690
TI  - [Action of washed cell suspension of different microorganisms on caffeic acid].

PMID- 1032691
TI  - [Sulfur-oxidizing and sulphate-reducing activities in various types of soil.
      Response to the addition of sulfur and organic matter].

PMID- 1032692
TI  - [Cell-wall-deficient forms in Citrobacter intermedius C].

PMID- 1032693
TI  - [A strain of Eurotium echinulatum Delacr. isolated from a black soil].

PMID- 1032694
TI  - [Generalized transduction of Pseudomonas putida with a thermosensitive mutant of
      phage pf16h2].

PMID- 1032695
TI  - [Criteria of pathogenicity in Staphylococcus epidermidis].

PMID- 1032696
TI  - [Numerical analysis of a group of aerobic Pseudomonas].

PMID- 1032697
TI  - [Growth inhibition of C. intermedium C3 and other microorganisms by soluble
      factors excreted into the culture media].

PMID- 1032698
TI  - Properties and electron microscopy of a Vigna-virus belonging to the Cucomovirus
      group.

PMID- 1032699
TI  - [Autonomic nervous changes in combined exposure to lead and arsenic].
AB  - The characteristic features of the clinical and functional indicators in the
      early stages are outlined. The impression is that the subjective feelings are
      being overlapped and objectified by the neurologic status. A considerable number
      of non-specific reactions with a tendency for generalization are established. It
      is presumed that in the latent period, the functional changes in the nervous
      system forerun those in the clinical course and blood. Emphasis is laid on the
      significance of the astheno-vegetative syndrome and some neurological signs for
      the early diagnosis.

PMID- 1032700
TI  - [Attempt to assess the effect of atmospheric pollution on human beings and
      experimental animals via biochemical indices].
AB  - Three biochemical methods--erythrocyte oxygen consumption, erythrocyte
      decarboxylation and oxygen consumption of tissue homogenates--to determine the
      influence of atmospheric pollution in populated communities are suggested. The
      first two methods which provide information on erythrocyte metabolism, employed
      both in humans and in animals experimented upon, adequately reflect the
      atmospheric pollution effect in four industrial areas, differing by the type and
      degree of pollution agents. Oxygen consumption in tissue homogenates of liver and
      kidney from experimental animals, raised in the same areas, exhibits an
      analogical correlation. The inference is reached that the degree of inhibition of
      the oxidation processes in the organism may be employed in atmospheric pollution
      effect assessment.

PMID- 1032701
TI  - [Effect of meteorological factors on the 3,4-benzpyrene concentrations in the
      ground air layer in the region of the city of Sofia].
AB  - An investigation is performed to determine 3,4-benzpyrene content in the Sofia
      area (in a single spot), covering a one-year period (1970), on the basis of mean
      monthly concentrations established through gas chromatography, and compared to
      some of the averaged meteorologic data. The correlation between 3,4-benzpyrene
      concentrations and some meteorologic factors found is corroborated by the
      clearcut seasonal fluctuations of 3,4-benzpyrene concentrations in the
      atmospheric air. An inversely proportional dependence is established of 3,4
      benzpyrene concentration to the summed up radiation, and directly proportional-
      to the dust amount. A rise of 3,4-benzpyrene concentration under conditions of
      the various types of temperature inversions, and a complex effect of meteorologic
      factors have been also noted. Moreover, an attempt is made at establishing the
      washing effect of rainfalls, and it has been found that up to a certain extent,
      such an effect really exists. The study performed shows in a clearcut manner that
      3,4-benzpyrene content is considerably influenced by a variety of meteorologic
      factors.

PMID- 1032702
TI  - [Ultraviolet radiation in the light microclimate of a city].
AB  - The problems of ultraviolet microclimate under conditions of urban environment
      are discussed. Changes in the quantitative and qualitative content of the
      ultraviolet radiation reaching the earth surface of free spaces, or else
      penetrating living premises, accounts for a characteristics of the short-wave
      spectrum supplied by the natural sun radiation, obviously unfavourable in
      biological and hygienic respect.

PMID- 1032703
TI  - [Health status and morbidity in schoolchildren from villages in Silistra and
      Tutrakan Districts].
AB  - This is study of the health state and morbidity rate in a group comprising 408
      schoolchildren from the Silistra and Tutrakan regions, aged 7 to 14 years. The
      results of the research demonstrate a slight lagging behind of the school
      children's physical development relative to children of comparable ages from the
      urban areas. Their health state is estimated as good, and the somatic neurotic
      morbidity--rather low. The most frequently encountered affections include
      diseases of the upper airways, infectious and dental diseases. A considerable
      number of slightly hypochromic anemias are also recorded.

PMID- 1032704
TI  - [Evaluation of the phase changes in cardiac activity in respect of age].
AB  - A comparative analysis is made of the chronocardiometric indicators among
      teenagers with a special reference to the age factor. The presence of phasic
      syndromes is established by the type of hyper- and hypodynamia of the myocardium
      in 22.3 per cent average of the children under study. Up to the 15th year of
      life, the diseases characterized by hyperdynamia show a two-times higher
      incidence in comparison with hypodynamia cases. In the 16 to 17-year age group
      the ratio is altered and accordingly reveals a predomination of hypodynamia
      conditions. Development of phase changes of the type of hyper- and hypodynamia in
      the myocardium is attributed to the anatomo-physiological characteristic features
      of the cardiovascular system during the puberty period. Parallel to aging, the
      discrepancy in development between heart and vessels gradually disappears. The
      relative myocardial hyperfunction, occurring as a compensatory reaction of the
      organism, loses its significance. The heart begins to work in a regimen of
      relative hypodynamia.

PMID- 1032705
TI  - [Age-related characteristics of motor coordination in schoolchildren during
      dynamic and static work].
AB  - An experimental study is conducted in a group of schoolchildren of varying ages
      with the purpose to establish the interrelations between muscles-antagonists upon
      performing dynamic and static work, requiring precision of muscular exertion. The
      methods employed include electromyography and dynamography. The obtained results
      show that upon performing movements with power-precision characteristics, both in
      static and dynamic work, the synchronous co-working of the two muscles
      antagonists proves to be the basic form of action. The electromyographic analysis
      proves the coordinating role played by the antagonist in the above described
      pattern of actions. It is furthermore established that in schoolchildren, aged 12
      13 and 16-17 years, accomplishment of the motor task is fulfilled more
      rationally, with less neuromuscular energy expenditure in comparison with 7 to 8
      year-old schoolchildren. In addition, after the age 12-13 years, a certain degree
      of stabilization in some of motor activity parameters takes place, brought on by
      improvement of motor activity regulation and control.

PMID- 1032706
TI  - [Physiological hygienic characteristics of the teaching by the new educational
      programs for grade III].
AB  - The effect of the new training curricula and plans on the reactivity, health
      state and physical development of third-grade pupils is studied. Simultaneously
      with researches into the experimental class, investigations are conducted in a
      control class also. The working-capacity curve in the experimental-class pupils
      yields more clearcut fluctuations in a negative sense, interpreted as an
      expression of greater fatigue, as compared to the control class. This is
      confirmed by reliable data about the changes in the functional state of the
      higher nervous activity, hemodynamics and neuroendocrine regulation. It is
      concluded that the hygiene-physiological characteristics of the reactivity and
      health state of pupils, trained according to the new curricula, gives sufficient
      reason to stress the necessity of accurate assessment and rather prolonged medico
      pedagogic observation with a view to obviate the cumulation of the described
      above negative effects on the organism of teenagers.

PMID- 1032707
TI  - [Seasonal changes in the makeup of the red blood of healthy children].
AB  - Hemoglobin and red blood count are studied in a series of 240 children, aged 7 to
      10 years (30 boys and 30 girls each in the various age groups), during the
      autumn, winter and spring. The research is performed in boarding-school
      conditions where all the children are subjected to identicad living conditions,
      The results point to the fact that both hemoglobin and erythrocyte indicators of
      the boys and girls in the ages covered by the study show a tendency to an autumn
      winter increase and spring reduction. The incidence of anemias does not rise
      during the spring season. No sex-related difference is established in the
      indicators under study.

PMID- 1032708
TI  - [Changes in the serum activity of lysosomal enzymes in rats after the use of
      propoxur (Baygon) insecticide. 2. The dynamics of beta-N-acetylglucosaminidase].
AB  - The influence of 1/50 and 1/10 LD50 of the monomethylcarbamate insecticide
      Propoxur (Baygon) on the lysosome enzyme beta-N-acetylglucose-aminidase serum
      activity is studied in white rats upon daily administration per os, over a period
      of 2, 4, 8, 15, 30, 60 and 90 days. A statistically significant increase of the
      enzyme activity is recorded at 15 days after introduction of 1/50 LD50, and at 15
      and 30 days after 1/10 LD50 administration, followed by a reduction of the
      activity and returning to normal values. In all likelihood, the harmful effect of
      Propoxur on the lysosome and cellular membrane decreases after the 15th day
      because of activation of the microsome enzymes which, in turn, speed up the
      process of rendering innocuous the insecticide administered.

PMID- 1032709
TI  - [Changes in lysosomal enzymatic activity during the limited feeding and physical
      loading of white rats].
AB  - The effect of deficient alimentation and physical exertion on the total and free
      activity of two lysosome enzymes: acid phosphatase and beta-N-acetylglucose
      aminidase, in liver homogenate, and in serum--for the latter enzyme, is
      investigated in a series of 63 white rats at two different durations of the
      experiment (20 and 140 days). An increase of the free activity of both enzymes is
      recorded in the groups subjected to a limited nutrition, an increase which is
      interpreted as an expression of enhanced permeability of the lysosome membrane
      during the transition to partial andogenous alimentation. The applied physical
      loading failed to produce additional changes in the activity of the lysosome
      enzymes under study.

PMID- 1032710
TI  - [Morphological changes in the organs of rats subjected to limited feeding and
      physical loading].
AB  - Changes in the liver, stomach, small intestine, kidneys, lungs, myocardium,
      aorta, spleen and mesenterial lymph nodes are studied histologically in 120 male
      white rats from the Wistar line, subjected to a deficient alimentation regime,
      with and without physical exertion. The observed slight degree of adiposogenital
      dystrophy of the liver during free feeding regime indicates that the latter is
      equivalent to overfeeding. Variations from the normal histological picture in
      some organs (liver, myocardium, stomach and small intestine) are detected in the
      groups undergoing rather prolonged, moderate undernourishment--a sign of the
      sensitivity of these organs to the limited supply of nutritive ingredients.
      Physical loading, combined with free alimentary regimen, exert a beneficial
      effect on the organism which is suggested by the morphological data disclosing a
      slightly enhanced function of the myocardium and kidneys in these animals.

PMID- 1032711
TI  - [Physical state and the capacity of agricultural machinery operators].
AB  - Based on anthropometric investigations, and on some biometrical indices and
      physiological parameters, the authors study the physical fitness and ability for
      work in a group of 1216 machine operators, engaged in farming activities. Upon
      comparison of the data obtained, practically insignificant differences are
      established for the respective age groups relative to the general population.
      Virtually equal indices are recorded in most of the cases. Emphasis is laid on
      the necessity to estimate the working load among technicians older than 45 years.

PMID- 1032712
TI  - [Lysosomal enzymatic activity in a hepatotoxic lesion in white rats].
AB  - Beta-N-acetylglucoss aminidase and beta-galactosidase serum activity, as well as
      total and free activity of the former in liver homogenate are studied in the
      listed below groups of rats experimented upon: group I--controls, group II--fed
      perorally with 200 000 IU/kg body weight vitamin A for seven days, group III-
      injected i.p. with 150 mg/kg body weight thioacetamide, 24 hours prior to
      sacrification, and group IV--thioacetamide was given within seven days of vitamin
      A treatment. The recorded serum and free activity rise of the enzymes under study
      is due to the increased permeability of the lysosome and cellular membrane in the
      group with high vitamin A doses; the increase of the permeability is more
      pronounced in the group treated with thioacetamide, and in the group subjected to
      the combined effect of the two factors.

PMID- 1032713
TI  - [Changes in serum beta-N-acetylglucosaminidase activity in obesity patients
      treated with various diets and physical exertion].
AB  - Changes in the serum activity of the lysosome enzyme beta-N-acetyl glucos
      aminidase are studied in 85 patients with varying degree alimentary overweight,
      undergoing treatment under sanatorial conditions with regimes including physical
      loading and a variety of diets: "free of carbohydrates" according to Atkins (31
      cases), poor in fats (16 cases) and rich in fats (38 cases). The enzyme activity
      shows a statistically significant rise in the middle and at the end of treatment.
      The differences discovered are interpreted as an expression of the participation
      of lysosomes and their hydrolytic enzymes in the transition period to partial
      endogenous feeding which is connected with the increased permeability of lysosome
      and cellular membranes.

PMID- 1032714
TI  - [Embryotropic action of phosalone].
AB  - The study on the embryotrophic action of phosalon insecticide preparation is
      conducted against the background of its comprehensive and thorough hygiene
      toxicologic assay. Pregnant white rats undergo treatment per os with 1/10 and
      1/100 LD50 throughout the entire gravidity period. Recordings are made of the
      quantity of corpora lutea, pre- and postimplantation lethality; the pedigree
      development is traced up to the end of the second postnatal month with readings
      being made of weight and length in the first postnatal day, presence or not of
      external malformations, weight increase and survival up to the end of the
      lactation period, day of eye cleft opening and hairing, and sex ratio. The
      presence of phosalon and phosalon-oxone in whole embryo homogenates is estimated.
      Enzyme activity of GOT, GPT, catalase, LDH, G-6-PD, RNA and DNA quantity are
      studied in the liver of newborns on the second postnatal day. Within 21 days of
      birth, the peripheral blood picture and visceral weight coefficient are also
      studied. Investigation of the peripheral blood picture, activity of catalase, GOT
      and GPT in the liver and serum, alkaline and acid phosphatase, and peroxidase in
      the serum is performed at the end of the second month. The results point to the
      presence of an embryotoxic effect at the level of the investigated hepatic
      indicators, detected on the 2nd day of the postnatal period, only at 1/10 LD50
      dose.

PMID- 1032715
TI  - [Individual variability in human requirements for food stuffs and energy and
      nutritional norms].
AB  - The regular modifications in man's need of energy and protein substances
      primarily under the effect of a variety of factors are investigated. Emphasis is
      laid on the broad limits of individual variations in terms of alimentary
      requirements of people, and on a number of facts suggesting that in some ses the
      regularity of variations is by no means clarified. The problem of the minimum
      energy expenditure required by the organism is dealt with, underscoring the role
      played in this respect by basic metabolism values, and by the maximum energetic
      potential. The problem of the influence of deficient feeding and immobilization
      on man's need of alimentary substances is also discussed, as well as the issue of
      optimal protein balance level in the organism, considered as a level securing to
      the organism the optimal possibilities of metabolic adaptation to external milieu
      effects.

PMID- 1032716
TI  - [Effect of acetylcholine on active ion transport across the epithelium of frog
      skin].
AB  - The effect of acetylcholine on isolated skin of Rana ridibunda is studied. The
      application of acetylcholine (1 mM) in Ringer's solution, washing the outer
      aspect of the skin, causes slow and smooth increase in the preparation's current
      and potential. Upon acetylcholine addition to the solution on the inner aspect,
      the increase of the above parameters runs a course along a two-peaked curve. It
      is presumed that in the latter case acetylcholine, prior to exert a direct effect
      on the epithelium, influences some of the nerve or glandular formations in the
      skin corium.

PMID- 1032717
TI  - [Possibilities of the biophysical evaluation of the efficiency of vibration
      protection devices for the hands].
AB  - The possibility of quantitative assessment of the efficiency of hand vibratory
      protective devices using a physiological parameter--the loss of vibrosensitivity
      in the right-hand fingers depending on the intensity of vibration effect--is
      discussed. The results of the experiments prove that in case of vibration effect
      at frequency 31--500 Hz, the changes in vibrosensitivity threshold might be
      employed as an experimental method of assaying the efficiency whenever it exceeds
      two decibels.

PMID- 1032718
TI  - [Method of determining system errors due to the quality of the electronic filters
      in the spectral analysis of noise vibration].
AB  - A method to determine systematic errors, conditioned by the extreme degree of
      fading out, beyond the permeability band of electric filters used in noise and
      vibrations' spectral analysis, is suggested. The obtained formulas for the active
      filters of the noise-measuring apparatus PSI-202, making part of the hygiene
      network equipment throughout the country, are tabulated and thus prompt
      determination of the respective systematic error is rendered possible.

PMID- 1032719
TI  - [Experimental substantiation of the maximum permissible concentration (MAC) of
      polyvinyl chloride resin].
AB  - The acute and chronic oral, dermal and inhalatory toxicity of PVH resin is
      studied in white rats. It is established that in acute treatment, irrespective of
      the route of PVC resin penetration into the organism, its effect proves weakly
      toxic. During chronic oral and inhalatory experiments, a slight affection of
      peripheral blood elements only is noted. In the lungs of the animals inhalating 2
      and 6 mg/m3 concentrations for a duration of four months, no changes are detected
      which might be interpreted as being PVH specific. Cumulative effect, and skin
      stimulating and sensibilizing action of the polymer are neither established.
      Against the background of the obtained results, a provisional normal MAC value is
      proposed, namely 2 mg/m3 of PVH dust in the air of the working environment.

PMID- 1032720
TI  - [Pathologicoanatomic and enzymatic histochemical changes in the body of white
      rats with chronic, intermittent pirimor pesticide poisoning].
AB  - Not infrequently, the continuous use of pesticides leads to production of
      resistant species of agricultural pests which makes imperative to adopt the
      practice of intermittent, i. e. periodic application of the agricultural
      preparations. In this work the difference in degree of pathoanatomical damage
      upon chronic and periodic, weekly application of the new carbamide pesticide
      Pyrimor, extensively used in the Bulgarian farming economy, is discussed. The
      results of pathomorphological and histochemical study of the chief parenchymatous
      organs shows a clearcut difference in the group with continuous administration of
      the pesticide, as compared to the control and intermittently poisoned group. It
      is furthermore pointed out that the two-times higher dose, introduced at weekly
      intervals, leads to slighter lesions of parenchymatous organs in comparison with
      chronic, oral Pyrimor treatment. Season related, incessant use of pesticides
      results in occupational risk increase among the workers engaged in farming.

PMID- 1032721
TI  - [Changes in enzymatic activity in rats with acute Unden poisoning].
AB  - The influence of Uden, exerted on the activity of GOT, GPT, LDH acid phosphatase
      and alkaline phosphatase in the serum, is investigated upon 4-day-long treatment.
      The experiment is conducted in three groups of white male rats with mean weight
      270 +/- 20 g. The first group of animals underwnt poisoning with 1/20 LD50, the
      second--with 1/4 LD50 while in the third, control group, the animals were treated
      with an oil solvent at the respective days. It is found that acid phosphatase,
      GOT and alkaline phosphatase activity in group two is virtually unchanged, whilst
      GPT activity in both experimental groups, and acid phosphatase in group one are
      reliably increased (P less than 0,01), with 20,17 and 53 per cent respectively.
      LDH activity is reliably lowered with 60 per cent in group two, whereas in group
      one a tendency for a reduction is noted (P less than 0,05).

PMID- 1032722
TI  - [Changes in liver dehydrogenase activity in rats with Unden poisoning].
AB  - Changes in LDH, SDH, MDH and G-6-PDH activity in the liver of white male rats are
      studied within 2, 4, 8, 15, 30, 60 and 90 days of treatment with 1/10 and 1/50
      LD50 and after 15 days recovery period following the 90-day-long treatment. The
      animals are divided up into three groups as follows: group one--treated with 1/10
      LD50, group two--with 1/50 LD50, and a control group treated with vegetable oil
      solvent at the respective days. The findings show that changes in enzyme activity
      are comparatively one-way in terms of duration of the treatment. In the early
      days of the experiment, a reliable increase is noted followed by a normalization
      of the values and reliable reduction. At ninety days, and after the recovery
      period is over, the activities of all five enzymes do not differ from those in
      the control groups. The most clearly outlined changes are recorded in SDH, and
      the slightest--in MDH. The analysis of the picture obtained shows that in all
      instances it is a matter of reversible changes.

PMID- 1032723
TI  - [Sanitary chemical evaluation and control of hazards in the varnishing ships of
      the furniture industry].
AB  - Using theoretical calculations and personal observations and researches, the
      authors succeeded in demonstrating that evaporation from lacquered surfaces,
      particularly in the early period of drying, is the primary source of working
      environment air pollution with toluene and styrol in the varnishing workshops of
      furniture factories. Three equations are submitted to calculate the quantities of
      evaporated volatile components from  the lacquer film of the machine, and from
      the varnished surfaces, equations which have been adopted in the practice of
      pollution sources' sanitary-chemical assay. Against the background thus outlined,
      the conclusion is reached that the varnishing machine is by no means the primary
      source of harmful effect provided the technology of varnish application employed
      does not require tools of the type of a conveyor line, pointing out furthermore
      that air pollution from the wheel-barrows, containing varnished details, is the
      most significant. Proceeding from the results of the research, it is recommended
      to carry out during of the varnished surfaces in a separate room or in a
      tunnelled drying room which, under conditions of updated technology of applying
      varnish, prove the most effective from sanitary hygienic viewpoint since they
      provide for the lowest toxic-vapour concentrations in the air of the working
      environment, and for optimal working conditions.

PMID- 1032724
TI  - [Electron microscopic study of lung dusts].

PMID- 1032725
TI  - [X-ray morphological changes and the degree of lost work capacity in silicosis
      patients].
AB  - In a series of 200 patients with silicosis an analogy is drawn between form,
      size, widespreading and evolution of the pneumoconiotic changes, on the one had,
      and working ability loss, on the other. It is established that the heavier the
      form of the pneumoconiotic process, the higher the degree of severity and
      widespreading of the roentgenmorphological changes in the lungs and the quicker
      the evolution, the heavier the retriction of the ability for work among the
      affected. The conclusion is reached that that the working ability of patients
      with silicosis represents a complex phenomenon resulting from numerous factors
      with varying in intensity effect. A new, more complex and updated method for the
      assessment of working ability in patients with silicosis is proposed.

PMID- 1032726
TI  - [Analysis of a subjective assessment of work and morbidity in modern jobs].
AB  - An analysis is made of the subjective assessment of work and morbidity in
      individuals engaged in two groups of up-to-date occupations: a) with
      considerable, and b) with insignificant nervous strain. The questionnaire study
      covers 1420 workers. Morbidity analysis is carried out on the basis of data from
      1980 temporary disability cards--90 per cent of the workers exposed to a
      substantial neurosensory stress feel tired at the end of the working day. It is
      accepted that the cause of fatigue is firstly, the sustained and continuous
      observation and secondly, the rhythm required. The greater concentration and
      monotomy are pointed out as the primary cause in group two. The incidence of
      central nervous system diseases among workshop supervisors and operators of
      punching machines definitely augments with the length of service. The morbidity
      rate of gastrointestinal and peripheral nervous system diseases is also rather
      high.

PMID- 1032727
TI  - [Skin mediator reactivity in workers in contact with lead].
AB  - The intracutaneous adrenomimetic test is discussed against the background of
      overall neurovascular reactivity. The skin-mediator test is recommended as a
      reference of the functional condition of vegetovasal substrates. A certain degree
      of synchronization between dermal reaction and degree of clinical syndromes and
      their stages is sought for. Emphasis is laid on parasympathetic excitation in the
      initial stage. Adrenergic reactivity considered in a constellation with the other
      indicators, has a definite diagnostic-prognostic value.

PMID- 1032728
TI  - [Autonomic nervous manifestations in combined exposure to lead and manganese].
AB  - An increased reactivity of the vegetative nervous system under manganese-lead
      effect is established in practically healthy workers during the latent stage. The
      dynamics of the combined toxic invasion is characterized by sympathetic
      adrenergic manifestations mainly. A number of vegetative disturbances showing a
      tendency for generalization, and involving various levels of the nervous system,
      are also outlined.

PMID- 1032729
TI  - Hair transplantation. The use of hairbearing compound grafts for correction of
      alopecia due to chronic discoid lupus erythematosus, traumatic alopecia, and male
      pattern baldness.
AB  - In this study 8 patients with alopecia due to chronic discoid lupus erythematosus
      (CDLE), 10 patients with traumatic alopecia (TA), and 12 patients with male
      pattern baldness (MPB) were treated with the punch graft method (PGM).
      Stastistical evaluations of the results and factors influencing the results were
      careied out. The mean survival rate of hairs was 72% in CDLE, 97% in TA, and 104%
      in MPB. The mean number of hairs in a 4 mm graft before transplantation in 30
      patients and 752 grafts was found to be 18.2. This is far more than the number
      reported in previous publications concerning PGM owing probably to the
      difficulties of counting several hairs simultaneously emerging from the same
      pilary canal when the hair is cut to a length of 1--2mm preoperatively. For this
      purpose the author has developed a special photographical magnifying system. The
      number of hairs surviving transplantation in MPB in a 4 mm graft was about 19
      hairs per graft, which is superior to previous reports. This is possibly due to
      some modifications of the procedure made by the author. In a control series done
      with the same technique as that often seen in the literature, about 50% inferior
      results were obtained. These results were however similar to those reported in
      the literature. Consequently the modifications of the procedure have been
      successful. Only one article with a series of 12 patients with TA treated with
      PGM was found in the literature. The hair survival results of the author exeeded
      the reported results by about 100%. The size, hardness, and elevation of the
      scars of the donor holes were checked statistically after various treatments. It
      was found that the diameter of the scar is the same regardless of type of
      treatment but that a signifcantly greater risk of hard and elevated scars is
      taken if the bald grafts are put back in the donor holes. No complications were
      seen in this series. PGM is a safe method that gives good hair survival results
      on transplanted hairs in MPB and TA, but the results vary in CDLE. In spite of
      the good results with PGM the author emphasizes that, although the therory of the
      method is simple, both the preoperative judement and the performance with its
      practical difficulties and many cosmetic problems is complex and requires a lot
      of psychological insight, practice and experience before correct preoperative
      judgement and a maximally good cosmetic result can be achieved.

PMID- 1032730
TI  - Micturition in infants and children with normal lower urinary tract. A urodynamic
      study.

PMID- 1032731
TI  - [Serial studies for the detection of juvenile bacteriuria].

PMID- 1032732
TI  - Effect of insulin on serum lipids in juvenile diabetes.
AB  - In diabetic children, the effect on serum lipids of insulin by itself and
      combined with glucose of with Aminosol + glucose has been studied. The level of
      serum free fatty acids decreased significantly in every case. The cephalin level
      decreased under the effect of insulin and insulin + Aminosol, whereas it rose
      after insulin and glucose infusion. The triglyceride level remained unchanged
      when insulin was applied by itself, and decreased significantly under the effect
      of insulin + Aminosol, while it showed a rising tendency after insulin + glucose
      infusion.

PMID- 1032733
TI  - Surveillance of congenital anomalies in Hungary.
AB  - Surveillance of congenital anomalies has various functions viz. monitoring (to
      detect clusters as soon as possible), registering (to contribute to medical care
      and to provide material for scientific research) and informative. The Hungarian
      Congenital Malformation Register records the occurrence of malformed babies
      diagnosed from birth to 1 year of age. The Register has 3 sources (obstetricians,
      paediatricians, pathologists) and has registered since 1971 over 4000 malformed
      infants annually, an occurrence of over 28%. Validity and completeness of
      notification depend on the type of malformation. A separate Monitor started on
      January 1st, 1973, is confined to congenital malformations detectable
      unequivocally and readily during the first seven days of life. So far four real
      clusters occurred in Hungary but their causes could not be found. Particular
      stress has been laid upon multiple malformations (syndromes) since all known
      teratogens affecting humans produce multiple malformations.

PMID- 1032734
TI  - [Fibrinogenderivatives in plasma and serum of newborn infants with respiratory
      distress syndrome].

PMID- 1032735
TI  - [Pancreas agenesia in the newborn, a rare, but clinically characteristic
      symptom].

PMID- 1032736
TI  - Abnormal tryptopham metabolism in congenital erythroid hypoplastic (Diamond
      Blackfan) anaemia.
AB  - Tryptophan loading was performed in a child with Diamond-Blackfan anaemia as well
      as in his parents and two control persons. There was a fivefold increase of
      anthranilic acid and kynurenine excretion beside a marked generalized
      aminoaciduria in the proband; in the parents and the controls no such phenomenon
      could be demonstrated. The importance of the finding is discussed and
      investigation of tryptophan metabolism before the first blood transfusion is
      recommended. The finding cannot be used as a heterozygote test.

PMID- 1032737
TI  - Methadone maintenance treatment of narcotic addiction: a unit of medical care
      based on over 50,000 patient treatment years.
AB  - The experience with methadone maintenance treatment by two major New York City
      methadone maintenance treatment programs using the Dole-Nyswander philosophy is
      reviewed. After more than 56,000 person-years in treatment over a 10-year period
      of time, a unit of medical experience exemplified by these two programs is
      evident. There was a high degree of patient acceptance, a small amount of
      recognized residual illicit drug abuse, and steeply reduced criminal activities
      of those patients who remained in treatment. A wide variety of other methadone
      treatment programs are recognized. Many use methadone differently from those in
      the present study. The treatment results reported herein may represent a standard
      by which narcotic (methadone and other) treatment programs can be assessed.

PMID- 1032738
TI  - Undetected opiate use in the Southwest: comparison of official drug-user files
      and treatment program patient records.
AB  - Highly disparate research techniques have been employed to develop estimates of
      the extent of opiate use. Exclusive reliance upon public health and law
      enforcement statistics has been supplemented in recent years with data generated
      by survey research "incidence and prevalence" epidemiological methods. State
      agencies attempting to measure the extent of opiate use as a requirement for the
      receipt of federal categorical grant formula funds utilize multiple indicators:
      opiate treatment, arrest, incarceration, serum hepatitis, narcotics overdose
      death, and survey data. To address the question of undetected opiate use in a
      major southwestern city, the authors have undertaken a study measuring the extent
      of law enforcement recognition of the addictive status of a random sample of
      patients selected from the city's two municipally operated methadone treatment
      programs. The results indicate that over one-half of the sample was unknown to
      the police as addicts. Descriptive attributes of the unknown group were
      identified through appropriate statistical analyses. These findings are
      comparable to those of a similar study conducted in 1973 in a major eastern city.

PMID- 1032739
TI  - Methadone dispensing by community pharmacies.
AB  - This study reports 1 year follow-up data of 96 patients who received methadone at
      selected community pharmacies instead of traditional program dispensaries.
      Outcomes are comparable to those reported for traditional programs. Security
      measures were not a problem. The results indicate that most patients can begin
      methadone maintenance at a pharmacy without a period of stabilization at a
      program unit. Of several factors studied, arrest record, both preceding and
      during treatment, based on official police data was the single factor
      significantly associated with employment and continuation in methadone treatment.
      Community pharmacy dispensing of methadone is a useful means of operating a
      methadone treatment program.

PMID- 1032740
TI  - A study of addicts' career experiences with methadone.
AB  - Recent public concern over illicit methadone use has generated considerable
      interest among both treatment authorities and researchers. Unfortunately, many
      professional studies on the topic have done little to clear up certain
      misconceptions surrounding methadone use. In building upon earlier empirical
      work, the authors sought to explore the role of methadone within the context of
      addict career experiences as a whole. Interviews revealed considerable
      differentiation in types of experiences and purposes for use with respect to a
      variety of demographic and drug career attributes. The findings suggest the need
      for some rethinking about prevailing conceptions of "the problem" of illicit
      methadone use.

PMID- 1032741
TI  - Methadone maintenance and the problem with alcohol.
AB  - There is a growing concern with the rapid pace of physical and psychosocial
      deterioration of methadone patients who abuse alcohol. The need for a sample
      method for determining the extent of the problem, as well as the presence of an
      alcohol problem in individual patients, led the authors to test the validity of
      the Michigan Alcoholism Sreen Test (MAST) in a small urban methadone maintenance
      clinic (N = 125). The MAST was administered to every patient by their counselors,
      and the nursing staff was asked to independently rate each patient according to
      Keller's definition of alcoholism. The authors compared the patients' MAST scores
      with the global ratings of the nursing staff. Forty-six percent (n = 58) of the
      patients scored in the alcoholism range of the MAST questionnaire, while 34% (n =
      43) of the patients were diagnosed as alcoholics by the nursing staff. There was
      75% (n = 94) agreement between the MAST findings and the nurses' global ratings
      (p less than .001). The authors suggest that the MAST could be an effective
      screening tool in the area of alcohol abuse in methadone clinics. Going beyond
      the data, the authors recommend reexamination by psychiatrists of their
      peripheral role in the treatment of these difficult and multihandicapped
      patients.

PMID- 1032742
TI  - The abuse of multiple drugs. I. Definition, classification, and extent of
      problem.
AB  - Drug abusers have historically tended to abuse more than one drug. However, over
      the past 5 years there has been an increasing tendency to combine narcotics,
      alcohol, sedatives, and/or stimulants. The statistical increase of such abuse in
      the United States is documented by national surveys and the findings of drug
      treatment programs and detoxification centers. To clarify the confusion about
      such terms as "polydrug abuse" and "multidrug abuse," these terms are defined. A
      classification of multiple drug abuse is presented which demonstrates recent
      increases in each of four categories.

PMID- 1032743
TI  - The abuse of multiple drugs. II. Psychological hypotheses, treatment
      considerations.
AB  - Several basic psychological hypotheses about multiple drug abuse are examined,
      i.e., social determinants, the effect of availability on extent of abuse, that
      drug abuse is a symptom rather than a disease, the relationship of social class
      to psychopathology, the lack of specificity of psychodynamics or psychopathology
      to drug choice, and the use of drugs to facilitate or obliterate concern with
      assertion, relieve neurosis, or provide homeostasis. There is a need for a
      variety of comprehensive, directive treatment approaches from which an individual
      treatment plan can be chosen. Such plans must consider which of the complex
      factors that can lead to multiple drug abuse are most prominent and can be
      remedied in each case.

PMID- 1032744
TI  - Variables related to length of stay in day programs for drug abusers.
AB  - In a study of client variables related to length of stay in two types of drug
      free day treatment programs, results varied according to program structure and
      sex of the clients. In the more loosely structured Youth Centers, in which the
      programs differed from center to center and the populations were heterogenous,
      there were no clear-cut results. However, within the more tightly structured
      Ambulatory Treatment Units, the programs and the populations were more
      homogeneous, and the results showed a significant pattern related to length of
      stay, but for males only.

PMID- 1032745
TI  - Clinical guidelines for the cross-cultural treatment of chemical dependency.
AB  - Clinicians should be skilled in work with their ethnic peers before attempting
      cross-cultural treatment. Acquiring cross-cultural sensitivity involves
      regression to childlike openness for new values, attitudes, and behaviors.
      Members of the ethnic group can orient the clinician by discussion, suggested
      readings, and invitations to their homes and ritual events. Work should begin
      slowly, with regular consultation from ethnic peers of the patient. Special
      transference issues involve parent-child transactions and the "Messianic
      countertransference." Clinicians must maintain their primary commitment to the
      patient and to the patient's social resources, rather than to an institution not
      responsible to the patient population.

PMID- 1032746
TI  - An epidemiological description of the development of drug dependence:
      environmental factors and prevention.
AB  - The "agent," "host," and "environment" of drug dependence are examined relative
      to their potential as effective foci of efforts in the areas of primary secondary
      and tertiary prevention. Factors associated with the agent and the host are shown
      to be of extremely limited value when it comes to the primary prevention of drug
      dependence. Results of prior rewards are reviewed and they serve as the basis for
      the conclusion that the manipulation of environmental factors holds the greatest
      promise relative to the primary prevention of drug dependence.

PMID- 1032747
TI  - Relationship of neonatal withdrawal to maternal methadone dose.
AB  - Neonatal withdrawal is described for a sample of 70 infants born to addicted
      women treated with methadone and comprehensive prenatal care. Although symptoms
      were manifested by over 90% of the infants, those born to women receiving near
      term average doses of less than or equal to 20 mg/day had significantly less
      symptomatology, weight loss, and need for pharmacologic treatment than those of
      mothers still on higher doses. Reduction of methadone dose levels during the last
      6 weeks of pregnancy to less than or equal to 20 mg/day appears to reduce the
      severity of neonatal withdrawal.

PMID- 1032749
TI  - Further comments on the communicable disease model of heroin addiction.

PMID- 1032748
TI  - Medical implications of marijuana use.
AB  - The effect of marijuana smoking was studied in 28 healthy young adult men who had
      previously smoked marijuana for approximately 5 years each. The subjects were
      hospitalized on a closed research ward for 31 days during which comprehensive
      psychological, physiological, and medical observations and tests were done.
      Physical examinations, neurological examinations, chest X-rays,
      electrocardiograms, and clinical laboratory tests were all within normal limits.
      Marijuana produced inconstant changes in pulse rate and blood pressure in these
      studies. Six subjects were found to have significant reduction in resting vital
      capacity during the baseline period of the study which were felt to be related to
      their prior marijuana smoking. In contradistinction to these findings, 12 of 15
      subjects had statistically significant increases in peak expiratory flow rate
      immediately following marijuana smoking. Body temperature tended to be slightly
      reduced during marijuana use.

PMID- 1032750
TI  - A note on the A.I.D. test and the youthful drug abuser.

PMID- 1032751
TI  - Narcotic use in an inmate population at three points in time.
AB  - Studies on new jail admissions conducted in 1969, 1971, and 1973 indicated a
      sharp decrease in heroin use among male inmates in the District of Columbia in
      1973. In the jail study conducted in 1969 among 225 inmates, 45% reported to be
      addicted to heroin, in 1971, 47% of the 150 inmates reported to be addicted, as
      compared to only 22% of the 200 inmates in 1973. Only 38% of the addict-inmates
      in 1969 reported ever receiving treatment for their addiction, while 62% in 1971
      and 64% in 1973 reported receiving treatment.

PMID- 1032752
TI  - Employment and social disability among opiate addicts.
AB  - This study examines the relationship between employment and social disability. It
      is based on admission data for 296 opiate addicts who enrolled in New York
      Medical College's Multitrack Abstinence Program during 1974. Social disability is
      defined here as an attribute of the patient which may count against him or her in
      the job market. Employment rates are examined in the light of an index comprised
      of three specific disabilities: minority group status, lack of a high school
      degree, and presence of an arrest record. It is found that the proportion of
      addicts employed upon admission to the program varies inversely with the number
      of disabilities. Furthermore, it is found that the proportion of addicts who rely
      on illegal acts for their main source of income varies directly with the number
      of disabilities.

PMID- 1032753
TI  - A follow-up study of 300 ex-clients of a drug-free narcotic treatment program in
      New York City.
AB  - This article deals with an attempt at evaluating the success of a drug-free
      narcotic treatment program in New York City through a follow-up study of 300 ex
      clients of the program. Two hundred ex-clients out of the 300 target population
      were actually interviewed. The number of months the clients had remained in the
      treatment program was found to be a key factor in the outcome of the program. The
      length of time in the program was itself highly dependent upon the client's
      background: the higher the pretreatment pathology the lower the chance of
      treatment success.

PMID- 1032754
TI  - Drug dependency: some etiological considerations.
AB  - In an effort to illuminate etiological aspects of drug dependency, some findings
      from genetics are examined for meaningful connections with psychological areas,
      particularly with regard to the contribution of Object Relations theory. The
      latter is described in some detail, using methadone maintenance treatment as an
      illustrative context. Connections between the two areas are described which
      increase an understanding of the relevance of each and which raise questions
      about the artificiality of the usual separation of biological and psychological
      approaches in this area.

PMID- 1032755
TI  - An analysis of psychedelic drug flashbacks.
AB  - Psychedelic drug flashbacks have been a puzzling clinical phenomenon observed by
      clinicians. Flashbacks are defined as transient, spontaneous recurrences of the
      psychedelic drug effect appearing after a period of normalcy following an
      intoxication of psychedelics. The paper traces the evolution of the concept of
      flashback and gives examples of the varieties encountered. Although many drugs
      have been advocated for the treatment of flashback, flashbacks generally decrease
      in intensity and frequency with abstinence from psychedelic drugs.

PMID- 1032756
TI  - The epidemiological approach to drug abuse: its relevance to the teaching of
      future professionals.
AB  - In most areas of the medical curriculum it is far more important to teach
      students the approach to problems, rather than to encourage rote learning of the
      specific diagnostic and therapeutic regimen indicated in every conceivable
      circumstance. This is especially true in the field of substance abuse, in part
      because there simply are no clear-cut answers which can be universally applied.
      Nevertheless, dogmatism has been all too common in the teaching as well as the
      treatment of addiction, and there is a general tendency to view the problem
      simplistically and to advocate a specific modality as the solution. Teaching new
      professionals to apply the holistic perspective of the epidemiologist will
      enhance the likelihood of establishing realistic program goals, and adopting a
      comprehensive, balanced approach.

PMID- 1032757
TI  - Use of a social indicator system to assess alcoholism among Indian people in
      Minnesota.
AB  - A social indicator system was used to assess alcohol-related problems among
      American Indian people in Minnesota. Instead of counting "cases," the method
      involved using "events" that were recorded by various social institutions in the
      course of their work. The system showed that Indian people commonly encountered
      alcohol-related "events" that led to death or to social institutions with a poor
      record of problem resolution (foster homes, jail, prison, welfare agencies).
      However, they infrequently appeared in psychiatric facilities with alcohol
      related "events."

PMID- 1032758
TI  - Sex differences in alcoholics: a comparison of male and femal alcoholics' self
      and spouse perceptions.
AB  - Self-perceptions of male and female alcoholics and the perception of them by
      their respective spouses were investigated in an attempt to study sex differences
      in alcoholics. The subjects were 20 male and 20 female hospitalized alcoholics
      and their spouses. Subjects were administered a modified Katz Adjustment Scale
      and the NIMH Mood Scale applied both to states of sobriety and intoxication. The
      results indicated that the female alcoholic is more likely to characterized by
      her spouse as guilty and depressed both in states of sobriety and intoxication
      than is the male alcoholic. The therapeutic implications of these and other
      findings are discussed.

PMID- 1032759
TI  - Reported drinking among posttreatment alcohol abusers: a preliminary report.
AB  - Posttreatment drinking behavior and job effectiveness ratings by supervisors are
      compared at 6, 12, and 24 months follow-up for young (age 25 and younger) and old
      (age 26 and older) male alcohol abusers admitted to Naval Alcoholism
      Rehabilitation facilities. Follow-up results indicate that: (1) large percentage
      of subjects were rated effective at their work following treatment; (2) effective
      subjects drank significantly less than noneffective subjects; (3) young subjects
      tended to drink significantly more than old subjects; (4) of those rated
      effective at their work, young subjects drank more and abstained less than did
      old subjects; (5) drinking behavior and work effectiveness ratings appear to
      remain consistent over the three follow-up periods. Some implications and
      limitations of the present study are discussed.

PMID- 1032760
TI  - Drug abuse in junior high school populations.
AB  - Illegal drug use in a population of 3,807 junior high school students in a
      suburban area appeared strongly correlated with family instability, student
      personal problems, and low academic performance. Use of tranquilizers,
      amphetamines, and sedatives was often motivated by attempts at self-medication to
      reduce painful feelings. Over 14% of illegal users took an overdose with about
      half of them intentional. Illegal users and nonusers agreed that drug education
      programs and the threat of legal penalties had little influence in their
      decisions about drugs.

PMID- 1032761
TI  - The spread of addiction-the role of the "average addict".
AB  - A survey of an accidental sample of 100 addict-clients indicates that
      approximately two-thirds of addicts induct others into the heroin culture.
      Typically, the number of new users recruited in this way is no more than one or
      two new users contacted by each experienced addict. The problems of interdicting
      the transmission process is complicated not only by the large numbers of persons
      involved in that process, but is further complicated by the fact that new users
      are recruited relatively early in the experienced users' careers when they are
      least likely to be known to treatment or law enforcement officials. The work of
      interdicting the spread of phenomenon is still further complicated by the fact
      that heroin is transmitted between friends under circumstances the experienced
      user can characterize, if with some possible exaggeration, as involving an effort
      to share a pleasurable experience and/or to meet others' requests.

PMID- 1032762
TI  - The black addict: I.Methodology, chronology of addiction, and overview of the
      population.
AB  - One hundred ninety-two Black, male heroin addicts in various phases of treatment
      and nontreatment, including never-treated active addicts and actively addicted
      treatment dropouts, were systematically interviewed for early life events,
      psychosocial variables, and natural history of addiction. This report presents
      the chronology of the addiction problem from childhood as well as evidence of
      significant early antisocial activities predating drug use in this population.
      Data on family characteristics, arrests, problems in formal schooling, and adult
      activities are summarized. The current work is compared to earlier data on
      comparable populations.

PMID- 1032763
TI  - A national follow-up study to evaluate the effectiveness of drug abuse treatment:
      a report on cohort 1 of the DARP five years later.
AB  - Preliminary findings for the first cohort of a national follow-up study of drug
      users admitted to treatment in the Drug Abuse Reporting Program (DARP) during
      1969-1971 are reported. From a sample of 1,853 selected for follow-up, 87% were
      located and interviews were completed for 77%. Gross tabulations are shown
      comparing several outcome measures based on pre-DARP treatment, the posttreatment
      period, and for the 2 months before interview. Sixty-one percent of all patients
      returned to treatment at some time after DARP termination. Decreases in drug use,
      expecially of opioids, were substantial and were generally accompanied by
      improvements in other outcome measures as well. Plans for more detailed and
      informative analysis of these and related DARP data are addressed.

PMID- 1032764
TI  - Drugs, Vietnam, and the Vietnam veteran: an overview.
AB  - Highlights are presented on the issue of drug use among servicemen in Vietnam and
      its aftereffects. Two stages of Vietnam drug use are identified-a period of
      increasing marijuana use followed by the 1970 influx of highly potent heroin to
      which 1/5 of the enlisted troops were addicted at some time during their tour.
      The major contributing factors appear to be: (1) the need of troops in stressful
      combat situations for self-medication, escape, and hedonistic indulgence; (2) the
      relaxation of taboos against drug use in the United States; and (3) the
      availability of illicit drugs at low cost, which was apparently the result of
      profiteering by a number of South Vietnamese officials. Related to the above was
      the growing disenchantment with the war and the progressive deterioration in unit
      morale. These drugs are seen as serving many of the functions performed by
      alcohol in earlier millitary conflicts. There is no hard evidence that duty
      performance in Vietnam was seriously affected by drug use. Since 95% of those who
      were addicted to narcotics in Vietnam have not become readdicted, the situation
      does not appear to be as severe as originally supposed. Myths as to the
      persistence and intractibility of physiological narcotic addiction were
      dispelled. A major negative effect has been the difficulty that soldiers with
      less-than-honorable discharges due to drug abuse have had in obtaining jobs.
      Other long-term effects from drug use are less clear and are difficult to
      separate from the overall effects of the war.

PMID- 1032765
TI  - The structure of heroin communities (in relation to methadone maintenance).
AB  - The sociocultural structure of contemporary urban heroin-using communities is
      delineated using the dimensions "being hooked," "scoring," and "hustling" on "the
      street." A concentric ring model is constructed with four rings: (innermost) the
      street dealing network, other criminal hustles, employed addicts, and a
      peripheral "recruitment" area (outermost). The model is used to define
      differential intentions toward and responses to methadone maintenance treatment
      among members of the heroin community.

PMID- 1032766
TI  - Drug overdose emergency room admissions.
AB  - The incidence and patterns of drug overdose admissions to the University of
      Michigan Medical Center Emergency Suite were studied for the first 3 months of
      each year from 1956 to 1970. Among variables investigated with regard to age,
      sex, and time comparisons were types of drugs used, purpose of ingestions,
      medical condition on arrival, disposition after emergency care, and history of
      treatment for emotional problems. The continuing escalation in drug overdose
      emergencies, primarily related to intentional self-poisoning, reflects the
      growing social health problems of drug use proliferation and rise in suicide
      attempts over the past two decades. Emergency room resources are being
      increasingly taxed by the psychological and medical care needs of these cases.
      Renewed effort toward primary prevention is essential.

PMID- 1032767
TI  - [Serum iron, copper and zinc levels in bronchial asthma (author's transl)].

PMID- 1032768
TI  - [An analysis of the histones obtained from calf and bovine brains (author's
      transl)].

PMID- 1032769
TI  - [Disturbances in blood coagulation and fibrinolysis in patients with different
      forms of acute leukemias (author's transl)].

PMID- 1032770
TI  - [Central action of ergothioneine (author's transl)].

PMID- 1032771
TI  - [The evaluation of the excretion of oestrogens and pregnanediol in some
      disturbances in the second trimester of pregnancy (author's transl)].

PMID- 1032772
TI  - [The influence of a high-salted diet on the content of total kininogen, its
      plasmic and urine fractions and on the level of prekallikreine on rat plasma
      (author's transl)].

PMID- 1032773
TI  - [Study on the usefulness of polyvinyl chloride containers (PCW) for injection
      solutions (author's transl)].

PMID- 1032774
TI  - [The influence of reserpine, phentolamine and propranolol on some parameters of
      the kininogen system in the plasma of rats fed on a high salted diet (author's
      transl)].

PMID- 1032775
TI  - [Serum concentration of magnesium in patients with a peptic ulcer (author's
      transl)].

PMID- 1032776
TI  - [Preliminary investigation on sterols and triterpenes in the Nepeta nuda L. herb
      (author's transl)].

PMID- 1032777
TI  - [The influence of polivinyl chloride containers (PCW) on the quality of 5%
      glucose solution for injections. Part II (author's transl)].

PMID- 1032778
TI  - [A comparative analysis of some species of Nepeta (author's transl)].

PMID- 1032779
TI  - [The influence of cyclophosphamide on the cytochemical picture of the neutrophils
      in the blood of patients with lung carcinoma planoepitheliale (author's transl)].

PMID- 1032780
TI  - [A contribution to the investigation on gastric ulcerations (author's transl)].

PMID- 1032781
TI  - [Studies on olfactory excitability in man (author's transl)].

PMID- 1032782
TI  - [The basic body measurements of the Lublin province peasants (author's transl)].

PMID- 1032783
TI  - [Experimental investigations of the effect of "Piascledine" pharmacological
      preparation on primary renal tubules (author's transl)].

PMID- 1032784
TI  - [The quantitative changes in blood serum proteins in rats under the influence of
      acute intoxication with lead acetate (author's transl)].

PMID- 1032785
TI  - [Morphological changes in the myocardium which accompany an infarct (author's
      transl)].

PMID- 1032786
TI  - [Experimental studies on the effect of Foschlor on a primarily damaged liver
      (author's transl)].

PMID- 1032787
TI  - [Histochemical reactions of dehydrogenases in the Myocardium of white rat after
      Andiamin application (author's transl)].

PMID- 1032788
TI  - [Pharmacobotanical research of the sub-species Viscum album L. I. Variability
      (author's transl)].

PMID- 1032789
TI  - [The paper chromatographic separaton of guanidine derivatives (author's transl)].

PMID- 1032790
TI  - [Pharmacobotanical research on the sub-species viscum album L. II. Saccharides
      (author's transl)].

PMID- 1032791
TI  - [Investigations on the concentration of sodium, potasium and calcium in eccrine
      sweat and in the blood serum in psoriasis (author's transl)].

PMID- 1032792
TI  - [The influence of DDT on the resorption and excretion of chloro-choline chloride
      (CCC) in rats (author's transl)].

PMID- 1032793
TI  - [Spectrophotometric determination of DNS Amino acids (author's transl)].

PMID- 1032794
TI  - Research on the chemical composition of the vascular wall. XV. collagen and
      elastin of the aorta wall of persons who died of vascular complications in the
      course of diabetes mellitus.

PMID- 1032795
TI  - Research on the chemical composition of the vascular wall. XVI.
      Glycosoaminoglycans of the aorta wall of persons who died of vascular
      complications in the course of diabetes mellitus.

PMID- 1032796
TI  - [Investigations on the quantity of exuded eccrine sweat in psoriasis (author's
      transl)].

PMID- 1032797
TI  - [The influence of 2,4-dichlorphenoxyacetic acid (2,4-D) on the resorption and
      excretion of chlorocholine chloride (CCC) in rats (author's transl)].

PMID- 1032798
TI  - [The effect of the 0,0-dimethyl-2,2,2-trichloro-1-hydroxiethyl-phosphate
      (Dipterex) on the mitotic activity of L-cells culture (author's transl)].

PMID- 1032799
TI  - [The effect of trypsination and the exchange of nutrition medium on the survival
      of tissue cultures intoxicated with phosphoroorganic compounds (author's
      transl)].

PMID- 1032800
TI  - [Investigations on coumarins of Archangelica officinalis Hoffm. fruits (author's
      transl)].

PMID- 1032801
TI  - [Estimation of degree of comminution of drugs in anal and vaginal suppositories
      prepared by different methods (author's transl].

PMID- 1032802
TI  - [Experimental research on the influence of antiasthmatic drugs on lung tissue
      (author's transl)].

PMID- 1032803
TI  - [Methodical research on the possibility of applying ferric chloride for the
      quantitative indication of citrates (author's transl)].

PMID- 1032804
TI  - [Oscillopolarographic analysis of cyclization products of 4-R-thio(selene)
      semicarbazones of pyridine aldehydes with alpha-chloro-ketones (author's
      transl)].

PMID- 1032805
TI  - [Oscillopolarographic analysis of the cyclization products of 4-R
      thio/selene/semicarbazides of pyridine acids with alpha-chloro-ketone (author's
      transl)].

PMID- 1032806
TI  - [Tests of applying phenyl izoselenocyanate for unveiling N-terminal amino acids
      of peptides chains and the synthesis of analogoues selenium of PTH-amino acids
      (author's transl)].

PMID- 1032807
TI  - Coronary blood flow and oxygen consumption by the heart following a hemorrhage.

PMID- 1032808
TI  - [The stimulating effect of adenine nucleotides on the incorporation of [32P]
      orthophosphate into proteins of isolated brain mitochondria (author's transl)].

PMID- 1032809
TI  - [The quantitative determination of DNS-amino acids by the planimetry technique of
      paper electrophoresis (author's transl)].

PMID- 1032810
TI  - Fetal cephalometry. An improved method and an evaluation.
AB  - A method of fetal cephalometry is described which is an advance on the combined A
      and B scan technique previously used. A flow chart has been prepared which
      clearly specifies the procedure to be followed. The criteria used when making an
      estimation are reported. The method is applicable to various types of machine and
      it can be taught to a good degree of accuracy in a short time to people with
      limited obstetric knowledge. There may be a significant difference between
      operators but this difference is roughly the same from patient to patient and
      decreases with training. It is considered that the chief source of variation is
      the failure to measure the same diameter on each occasion.

PMID- 1032811
TI  - Serum oestriol in normal pregnancy.
AB  - Serial measurements of serum oestriol (E3) were made in 56 normal pregnancies
      from 10 to 40 weeks gestation using a radioreceptor assay. Several parameters of
      the assay and its intrapatient variability were examined. The mean curve for
      pregnancy E3 levels and limits of normal variation have been identified and
      compared with those of other series. A positive correlation was found to exist
      between infant birth weight and the last E3 value in normal pregnancies prior to
      the onset of labour. Advantages of serum E3 assays over urinary E3 determinations
      are discussed.

PMID- 1032812
TI  - Carbohydrate metabolism in pre-eclampsia.
AB  - Intravenous glucose tolerance tests were performed on 30 primigravidae with pre
      eclampsia and 15 normal primigravidae in late pregnancy. The groups were matched
      for age, height and weight and had no stigmata of potential diabetes. Plasma
      glucose, plasma immunoreactive insulin and plasma placental lactogen (HPL) levels
      were measured before (fasting) and at timed intervals after the glucose
      challenge; the glucose response was expressed as the increment index. The
      patients with severe pre-eclampsia had significantly lower fasting plasma glucose
      levels than those with mild pre-eclampsia and normal pregnancies. The mean
      increment index in both the severe and mild pre-eclamptic groups was
      significantly lower than that of the normal pregnant group. Fasting HPL levels
      were significantly lower in patients with severe pre-eclampsia than in those who
      had mild pre-eclampsia or a normal pregnancy. Both the fasting plasma insulin and
      insulin response following glucose injection were lower in patients with severe
      pre-eclampsia than in those with mild pre-eclampsia or a normal pregnancy. The
      differences however were not statistically significant. The results of this study
      suggest that carbohydrate metabolism in severe pre-eclampsia is altered to an
      extent similar to that in patients with chemical gestational diabetes, and this
      alteration may be due to maternal beta-cell anoxia caused by the vascular changes
      in pre-eclampsia.

PMID- 1032813
TI  - The cause of the fall in serum folate in normal pregnancy.
AB  - Study of a complete antenatal population, a group of normal primigravid singleton
      pregnancies, and a group of normal twin pregnancies, suggests that the fall in
      the serum folate concentration which occurs in normal pregnancy is due
      principally to plasma volume expansion and should therefore be regarded as
      physiological.

PMID- 1032814
TI  - Plasma solute concentrations during gonadotrophin-induced ovulation.
AB  - The effects of ovulation induction on some plasma solute concentrations were
      investigated serially in eleven women, nine of whom conceived in that cycle.
      Increasing oestrogen output during the follicular phase was associated with
      decreasing levels of osmolality, urea, total protein and the albumin free protein
      fraction. Smaller decreases in the concentrations of sodium, potassium, chloride,
      carbon dioxide combining power (CO2CP) and albumin were not statistically
      significant. The luteal phase was marked by a rise in osmolality and a fall in
      CO2CP but no other significant changes. Levels of osmolality, sodium and
      potassium fell in early pregnancy when oestrogen output was further increased.
      These results appear consistent with an oestrogen induced expansion of the
      extracellular fluid compartment by retention of water in excess of solute, which
      might also account for the similar changes in pregnancy.

PMID- 1032815
TI  - Haematological changes during ovulation-induction by gonadotrophins.
AB  - The oestrogen response to ovulation-induction by gonadotrophins initiates a
      preovulation rise in total leucocytes and promotes fluid retention. In
      consequence of the latter, cyclic changes occur in blood haemoglobin and the
      haematocrit. The level of oestrone excretion in the follicular phase of induced
      cycles indicates that multiple follicular development probably occurs, and this
      also appears to affect the luteal phase. It seems likely, therefore, that the
      data present a rather exaggerated picture of the situation which obtains in
      normal menstrual cycles.

PMID- 1032816
TI  - The fetal membranes as a possible source of amniotic fluid prostaglandins.
AB  - Biosynthesis and metabolism of prostaglandins was studied in human amniotic and
      chorionic membranes obtained at term. Using specific in vitro methods it was
      demonstrated that the fetal membranes contain an organization of enzymes
      regulating both synthesis and degradation of prostaglandins. Differentiation
      between amnion and chorion showed that virtually all of the biosynthesis and
      metabolism occurred in the chorion, whereas enzymatic activities in the amnion
      were negligible or low. The results suggest a high turnover of prostaglandins in
      the chorion, and its importance as a source of prostaglandins found in amniotic
      fluid is discussed.

PMID- 1032817
TI  - Prostaglandin dehydrogenase in the placenta before and after the onset of labour.
AB  - Inactivation of prostaglandins in the placenta was studied using an assay for 15
      hydroxy-prostaglandin dehydrogenase (PGDH). Forty-four patients with normal
      single pregnancies between 38 and 42 weeks gestation were studied. Placentae were
      obtained before the onset of labour in 9, after spontaneous labour in 18, and
      after oxytocin-induced labour in 17 cases, PGDH-activity ranged from 54 to 495
      nanomoles PGF2alpha/g placenta/minute, with a mean +/- SEM of 207 +/- 18
      nanomoles/g/minute. The results indicate that the PGDH content of the human
      placenta does not change markedly with the onset or during the process of labour.
      The length of either spontaneous or oxytocin-induced labour was not influenced by
      the PGDH content of the placenta.

PMID- 1032818
TI  - Placental pathology in midtrimester pregnancies interrupted by intra-amniotic
      injection of hypertonic urea.
AB  - The histological appearances of 52 placentae from patients who had a urea-induced
      second trimester abortion were studied. Extensive subchorionic intervillous
      fibrin deposition and swollen degenerated stromal cells (probably Hofbauer
      cells), were found both in the placenta and membranes. Between urea injection and
      abortion, serial vaginal smears showed signs of progesterone deficiency. The urea
      induced placental and fetal damage was similar to that seen with hypertonic
      saline.

PMID- 1032819
TI  - The effect of daily norethisterone (0.35 mg) on cervical mucus and on urinary LH,
      pregnanediol and oestrogen levels.
AB  - The effect of 0.35 mg of norethisterone daily on cervical mucus and on urinary
      LH, pregnanediol and oestrogen levels was studied during two treatment cycles in
      five subjects who had been observed during a control cycle. Variable changes in
      hormone excretion patterns were found and are discussed.

PMID- 1032820
TI  - The use of a computer in an obstetric department.
AB  - Experience with a computer in an obstetric department is presented. A regular
      statistical analysis of the work of the department was readily available and
      computer printed summaries were produced for 86 per cent of the patients within
      one week of their discharge home. Solutions to problems encountered are
      discussed. It is concluded that a computer can be used economically and
      advantageously in this way even in hospitals without a computer on site. Future
      developments in the use of the computer are outlined.

PMID- 1032821
TI  - Intestinal gangrene due to giant-cell arteritis. Report of a case.

PMID- 1032823
TI  - The scope of modern anatomy.

PMID- 1032822
TI  - Arterial reconstruction to the profunda femoris artery.

PMID- 1032824
TI  - Gosumecs' contribution to helminthiasis.

PMID- 1032825
TI  - The nature of immunity: part II.

PMID- 1032826
TI  - Niflumic acid in the management of rheumatoid and osteoarthritis.

PMID- 1032827
TI  - Asymptomatic bacteriuria in school children.

PMID- 1032828
TI  - Some aspects of social obstetrics.

PMID- 1032829
TI  - Study of socio-psychological aspects of burns in females.

PMID- 1032830
TI  - Recurrent arthritis: unusual presentation of leprosy.

PMID- 1032831
TI  - Studies on the mechanism of hypotensive action of a disubstituted piperazine
      derivative (part II).

PMID- 1032832
TI  - Poor acceptability of "Pill-a-month" contraceptive. High pregnancy and drop-out
      rates in a small sample.

PMID- 1032833
TI  - Acute renal failure and methaemoglobinaemia due to copper sulphate poisoning.

PMID- 1032834
TI  - Congenital contractural arachnodactyly.

PMID- 1032835
TI  - Infantile polymyoclonia.

PMID- 1032836
TI  - Chlorpromazine poisoning with abnormal electrocardiogram (a case report).

PMID- 1032837
TI  - Hemoglobin-E, disease with mitral stenosis (a case report).

PMID- 1032838
TI  - [Experience with obstetric and perinatal care in the rural areas].

PMID- 1032839
TI  - [Analysis of 216 cases of eclampsia].

PMID- 1032840
TI  - [Registration of high risk fetal environment].

PMID- 1032841
TI  - [Plasma levels of gonadotropic prolactin and ovarian hormones during lactation].

PMID- 1032842
TI  - [Cortisol in amniotic fluid in normal pregnant women].

PMID- 1032843
TI  - [Congential suprarenal hyperplasia].

PMID- 1032844
TI  - [Deficiency of factor V in obstetrics and gynecology].

PMID- 1032845
TI  - [Cystic dilatation of the choledochus during pregnancy, and puerperium].

PMID- 1032846
TI  - [Haloperidol poisoning].

PMID- 1032847
TI  - [Acute thallium poisoning].

PMID- 1032848
TI  - [Imipramine poisoning].

PMID- 1032849
TI  - [Results of hyposensitization treatment in children with bronchial asthma.
      Preliminary discussion].

PMID- 1032850
TI  - [Dermatoglyphics and childhood diabetes].

PMID- 1032851
TI  - [Nontubercular pleural effusion in children].

PMID- 1032852
TI  - [Pyridoxine sensitive sideroachvestic anemia].

PMID- 1032853
TI  - [Vitamin E].

PMID- 1032854
TI  - [Evaluation of the nutritional status and its relation to certain variables of
      biological risk in children of low birth weight].

PMID- 1032855
TI  - An unusual case of papillary carcinoma of the thyroid; intraglandular
      dissemination associated with perifocal infiltrations by lymphocytes and lymph
      follicles.

PMID- 1032856
TI  - Effects of electrical acupuncture on human somatosensory evoked potentials.

PMID- 1032857
TI  - Studies on the early receptor potential in the human eye. VI. ERP in the fellow
      eyes of patients with idiopathic retinal detachment.

PMID- 1032859
TI  - The effect of hypoxia on the rabbit uterine activity.

PMID- 1032858
TI  - Electrophysiological and histological studies on the sensibility of the bone
      marrow nerve terminal.

PMID- 1032860
TI  - Effects of psychotropic drugs on monoamine oxidase activity in individual nuclei
      of hypothalamus and amygdala in rat.

PMID- 1032861
TI  - Echocardiographic features of primary pulmonary hypertension.

PMID- 1032862
TI  - Switch-off behavior and stage of sleep: a preliminary report.

PMID- 1032863
TI  - [On the tracheo-esophageal arteries of the human cervical and upper thoracic
      regions (author's transl)].

PMID- 1032864
TI  - A case of the duplicate palmaris longus muscle.

PMID- 1032865
TI  - [Electron microscopic studies on the development of the post-capillary venules in
      the rabbit lymph nodes (author's transl)].

PMID- 1032866
TI  - Is viviparity the best means of reproduction?
AB  - Successful reproduction in the context of evolution demands no more than
      perpetuation of the species, but an ideal system of reproduction should also aim
      for high efficiency. Two basic systems have predominated: egg laying and
      viviparity with placental attachment of the embryo to the mother. Egg-laying is
      inefficient in allowing huge losses and greatly limits the size of the newborn,
      although it has the advantage of causing little physiological upheaval to the
      mother. Viviparity, on the other hand, allows the growth of a much larger fetus,
      offers great protection and is highly efficient. Its major disadvantage is the
      enormous disturbance of the mother's physiology in the interests of ensuring that
      the fetus will not be rejected immunologically and that a continuous supply of
      nutrients can be provided and waste products removed. Only the marsupial seems to
      have achieved a sensible compromise by producing the young at a very early stage
      when it is living as an egg embryo without the need for placentation, and then
      giving it continuous nourishment and great protection by milk feeding in an
      external pouch.

PMID- 1032867
TI  - [Dermatoglyphic studies in children with mental defects].

PMID- 1032868
TI  - [The growing skull. Part I. Neurocranium. Statistical considerations (author's
      transl)].
AB  - Measurements were made on the radiographs of the skull of 540 boys and 496 girls
      obtained in the years 1951-1968. Distances and angles were established with the
      Tuberculum sellae as the centre. The subjects ranged in age from the first day of
      life till late puberty. They were divided into 26 groups comprising smaller
      periods in earlier life, and increasing with age. Results are presented of
      measurements of 9 distances and 3 angles exclusively concerning the neurocranium.
      The neurocranium of the girls is smaller than that of the boys from the first day
      of life and the difference is growing with age. The angles displayed little sex
      differences. The greater part of the growth of distance takes place in the
      earliest period of life.

PMID- 1032869
TI  - Serum concentrations of individual monocarboxylic short-chain fatty acids C2-C6
      in underweight children.
AB  - The serum concentrations of individual short-chain fatty acids containing 2-6
      carbon atoms were studied in 12 underweight children. Mean n-butyric and iso
      valeric acid levels were significantly elevated in underweight children, while
      those of n-valeric and iso-caproic acids were not significantly higher than in
      the control group. The level of total free fatty acids was also increased in the
      underweight group. A reduced enzymatic activity in fatty acid synthesis is
      supposed to be the factor underlying the impaired lipogenesis.

PMID- 1032870
TI  - [The plasma concentration of unconjugated 11-hydroxycorticosteroids in mature low
      bithweight infants during the first days of their lives].

PMID- 1032871
TI  - Lyell's syndrome: histological, immunohistochemical and serological observations.
AB  - Observations of Lyell's syndrome in two girls, one 2 and the other 7 years of
      age, investigated serologically, histologically and by immunofluorescent
      technique, are reported. In both cases. the disease had been preceded by a
      prolonged or repeated treatment with acetylsalicylic acid, in the first case in
      combination with sulphonamides and antibiotics and in the second in combination
      with mephenytoin. Immunofluorescent staining revealed immunoglobulins in
      subepidermal blisters and along the dermal vessels. Acetylsalicylic acid has been
      assumed to have been one of the causative factors of the violent progression of
      toxic epidermal necrolysis, probably by an antigen-antibody reaction. This has
      been supported by serologic demonstration of antibodies to acetylsalicylic acid
      in both cases.

PMID- 1032872
TI  - Diagnostic aspects in 117 patients treated surgically for thyroid carcinoma.

PMID- 1032873
TI  - Peritoneal lavage with doxycycline in acute diffuse peritonitis.

PMID- 1032874
TI  - Results of regional portal infusion of 5-fluorouracil in patients with primary
      and secondary liver cancer.
AB  - The survival of 47 patients with liver malignancies treated with continuous
      portal infusion of fluorouracil (5-FU) has been studied. 18 of them had been
      treated initially by hepatic artery ligation. Total mean survival was 9.4 months.
      Patients treated with hepatic artery ligation + 5-FU lived longer (mean 10.8
      months) than those treated with 5-FU alone (7.4 months). The survival was longer
      than could be expected for patients treated for primary liver cancer or for liver
      metastases from  colo-rectal cancer, when compared with the "untreated" group. It
      is concluded that continuous portal infusion of 5-FU appears to prolong survival
      in some groups of patients with malignant liver tumours. However, the influence
      of "unspecific, general" therapy is difficult to evaluate.

PMID- 1032875
TI  - The aetiology of acute pancreatitis.
AB  - The most common aetiological factors of acute pancreatitis in an unselected group
      of 215 consecutive surgical patients were biliary tract disease (40.0%),
      alcoholism (20.0%) and gastroduodenal ulcer (4.2%). In women, biliary tract
      disease was by far the most common cause (61.3%), but in men considerably high
      frequencies of alcoholism (48.3%) and gastroduodenal ulcer (15.7%) were noted as
      at least one possible aetiological factor. This deserves a special notation when
      contemplating prophylactic measures to prevent recurrences of acute pancreatitis.

PMID- 1032876
TI  - Intestinal blind pouch- and blind loop- syndrome in children operated previously
      for congenital duodenal obstruction.
AB  - A follow-up study of 27 children operated for congenital duodenal obstruction
      (CDO) in the years 1953--71 is presented. Nine children belonged to the intrinsic
      and 18 children to the extrinsic group of CDO. A total of 7 retrocolic,
      isoperistaltic, side-to-side duodeno-jejunostomy, 7 Ladd's operation, 8
      duodenolysis, 2 reduction of midgut volvulus, 2 duodenostomy a.m. Morton and one
      gastro-jejunostomy were performed at the age of 1 day--15 years. The clinical and
      radiological examinations were performed 3--21 years (mean 10 years 2 months)
      after these operations. In 3 cases there was a moderate duodenal dilatation, but
      reoperation was not necessary. During the follow-up period, one boy, now aged 8
      years, developed a blind pouch-syndrome in the I portion of the duodenum
      containing a 5 x 5 cm phytobezoar 4 1/2 years after duodeno-jejunostomy. The
      frequency of blind pouch-syndrome after duodeno-jejunostomy was thus 1:7 or 14%.
      One girl, now aged 9 years, developed a blind loop-syndrome in the ileocaecal
      segment 3 months after side-to-side ileotransversostomy, which was performed from
      adhesion-obstruction after duodenolysis for malrotation I and CDO. Both the blind
      pouch- and the blind loop-deformation were resected and the children recovered
      well. To avoid blind-pouch- and blind loop-deformations in the intestines, the
      anastomosis must be made wide enough, and especially in the surgery of the jejuno
      ileo-colic region an end-to-end anastomosis is preferable.

PMID- 1032877
TI  - Short-stay varicose vein surgery.
AB  - From 1967 patients attending for varicose vein surgery at the Meilahti Hospital,
      Helsinki University Central Hospital, have been operated on on the day of
      admission, spend the following night in the bed ward and are discharged the
      morning after the operation. The operation is performed under general anaesthesia
      with as radical approach as possible stripping the long saphenous vein and, if
      required, the short saphenous vein, excising the superficial side branches and
      ligating incompetent perforators. In the study a follow-up examination was
      carried out on 2334 patients. Wound infections occurred in 1.8%. Two patients had
      transient arrhythmia, and one a late haemorrhage. More serious complications were
      absent. During the follow-up period 5.2% of patients were operated on for
      recurrent varicose veins. 84.6% were subjectively satisfied. The number of
      hospital days per patient averaged 1.2. It was possible to follow the above
      planned course of action in 93.4%. The organization and surgical technique can be
      recommended in order to achieve savings in hospital days and to produce permanent
      and good surgical results.

PMID- 1032878
TI  - A comparison of dicloxacillin and ampicillin in the antibiotic prophylaxis of
      total hip replacement.
AB  - The effect of two semi-synthetic penicillins, dicloxacillin and ampicillin was
      compared in systemic antibiotic prophylaxis in total hip replacement patients.
      The drugs were given in routine oral dosage for eight days to two patient groups
      each consisting of 50 patients. There was no fatality. In the ampicillin group
      there were three staphylococcal infections but no infections in the dicloxacillin
      group. Two of the infections occurred in reapplication cases leading to the
      loosening of the prosthesis. One infection appeared after a primary operation
      with a superficial recurrence 10 months later. In the ampicillin group, side
      effects were diagnosed in 12 cases and in the dicloxacillin group in one case.

PMID- 1032879
TI  - Amniotic fluid removal prior to saline abortion.
AB  - To evaluate whether removal of the amniotic fluid prior to the instillation of
      200 ml of 20% hypertonic saline has any effect on the success, speed, and safety
      of the abortion process, 192 patients at 15--20 weeks' gestation were aborted
      according to one of the following procedures: 1) instillation of 200 ml saline
      without removal of the amniotic fluid (92 subjects), 2) removal of 100 ml of
      amniotic fluid prior to saline instillation (46 subjects), and 3) removal of 150
      ml of amniotic fluid prior saline instillation (54 subjects). The study indicated
      that there are no apparent advantages to the removal of the amniotic fluid prior
      to the instillation of 200 ml of hypertonic saline. The median times from
      instillation to abortion and rates of incomplete abortion were similar for the
      three groups of patients. Rates of specific complications, except for fever, were
      similar for the three groups.

PMID- 1032880
TI  - Complications in acute pancreatitis.
AB  - In a group of 260 non-selected cases of acute or subacute pancreatitis, severe
      complications occurred in 60 (23.1%). Long lasting shock and/or massive internal
      bleeding (5.4%), severe renal problems (anuria, tubular necrosis, nephrosis)
      (5.4%) and frank hepatic failure due to extensive liver necrosis or other severe
      destruction (5.0%), invariably lead to death. The clinical group of findings
      pointing to a fatal course usually manifested themselves during the first three
      days. Severe renal and hepatic lesions were in many cases secondary to shock in
      fulminant rapidly deteriorating cases. Preventing and efficient management of
      shock are thus essential prerequisites for saving the patient. Other important
      complications included severe intra-abdominal suppuration and abscesses,
      peritonitis and sepsis (3.9%), pseudocysts of the pancreas (5.4%) and biliary
      statis (18.4%). Severe obstruction to bile flow with associated jaundice occurred
      in only 4.6% of cases; unselected operative biliary decompression does not
      therefore appear indicated. If an early laparotomy is performed, efficient
      debridement and drainage are of utmost importance. Fatal panreatitis was
      associated with extensive necrosis of the pancreas in about 80% of cases;
      possibly subtotal pancreatic resection at an early laparotomy would have given
      better results in these most severe cases, as recently reported in the
      literature.

PMID- 1032881
TI  - Ocular signs and local treatment in myasthenia gravis.

PMID- 1032882
TI  - Self-management treatment of smoking behavior.

PMID- 1032883
TI  - [Ciliated structures in gynecological pathology. Experimental reproduction
      (author's transl)].

PMID- 1032884
TI  - Choice, determinism and value in the light of biological knowledge.

PMID- 1032885
TI  - Serum pseudocholinesterase activity in acute myocardial infarction.

PMID- 1032886
TI  - Learning of leg position by the ghost crab Ocypode ceratophthalma.

PMID- 1032887
TI  - Promoting mental health in school.

PMID- 1032889
TI  - Persistent and atypical lobules in the human breast may be precancerous.
AB  - Persistent human mammary lobules (PL) remaining after the menopause, and certain
      atypical lobules (ALA) are morphologically similar to the common preneoplastic
      hyperplastic alveolar nodule (HAN) of mice of strains having a high incidence of
      mammary carcinoma. This and other evidence suggest that like the HAN of mice
      human PL and ALA are precancerous.

PMID- 1032890
TI  - The effect of embryo extract on the types of collagen synthesized by cultured
      chick chondrocytes.

PMID- 1032891
TI  - Medical history questions predictive of myocardial infarction. Results from the
      Kaiser-Permanente epidemiologic study of myocardial infarction.

PMID- 1032892
TI  - Comparison of metabolism of free fatty acid by isolated perfused livers from male
      and female rats.
AB  - Livers from normal, fed male and female rats were perfused with different amounts
      of [1-14C]oleate under steady state conditions, and the rates of uptake and
      utilization of free fatty acid (FFA) were measured. The uptake of FFA by livers
      from either male or female rats was proportional to the concentration of FFA in
      the medium. The rate of uptake of FFA, per g of liver, by livers from female rats
      exceeded that of the males for the same amount of FFA infused. The incorporation
      by the liver of exogenous oleic acid into triglyceride, phospholipid, and
      oxidation products was proportional to the uptake of FFA. Livers from female rats
      incorporated more oleate into triglyceride (TG) and less into phospholipid (PL)
      and oxidation products than did livers from male animals. Livers from female rats
      secreted more TG than did livers from male animals when infused with equal
      quantities of oleate. The incorporation of endogenous fatty acid into TG of the
      perfusate was inhibite) by exogenous oleate. At low concentrations of perfusate
      FFA, however, endogenous fatty acids contributed substantially to the increased
      output of TG by livers from female animals. Production of 14CO2 and radioactive
      ketone bodies increased with increasing uptake of FFA. The partition of oleate
      between oxidative pathways (CO2 production and ketogenesis) was modified by the
      availability of the fatty acid substrate with livers from either sex. The percent
      incorporation of radioactivity into CO2 reached a maximum, whereas incorporation
      into ketone bodies continued to increase. The output of ketone bodies was
      dependent on the uptake of FFA, and output by livers from female animals was less
      than by livers from male rats. The increase in rate of ketogenesis was dependent
      on the influx of exogenous FFA, while ketogenesis from endogenous sources
      remained relatively stable. The output of glucose by the liver increased with the
      uptake of FFA, but no difference due to sex was observed. The output of urea by
      livers from male rats was unaffected by oleate, while the output of urea by
      livers from females decreased as the uptake of FFA increased. A major conclusion
      to be derived from this work is that oleate is not metabolized identically by
      livers from the two sexes, but rather, per gram of liver, livers from female rats
      take up and esterify more fatty acid to TG and oxidize less than do livers from
      male animals; livers from female animals synthesize and secrete more triglyceride
      than do livers from male animals when provided with equal quantities of free
      fatty acid.

PMID- 1032893
TI  - Control of mating preferences in mice by genes in the major histocompatibility
      complex.
AB  - When a male mouse is presented with two H-2 congenic two female in estrus, his
      choice of a mate is influenced by their H-2 types. The term "strain preference"
      is used to describe the general tendency of the male population of one inbred
      strain to prefer two female of one H-2 type rather than another. The term
      "consistency of choice" is used to describe the added tendency of particular two
      males of one inbred strain, in sequential mating trials, to prefer two females of
      the H-2 type they chose in previous trials. Statistical analysis showed trends in
      the data that support the following conclusions: (a) The choice is made by the
      male, not the female. (b) The strain preference of two males may favor two
      females of dissimilar H-2 type (four of six comparisons), or of similar H-2 type
      (one of six comparisons). (c) Consistency of choice does not always correspond
      with strain preference. In one of six comparisons of H-2 genotypes there was no
      strain preference but pronounced consistency of choice by individual two male.
      This suggests memory, but fortuitous bias is not excluded. (d) Strain preference
      of the same male population may favor two male of the same or a different H-2
      type, depending on which different H-2 type is offered as the choice alternative
      to self. These findings conform to a provisional model in which olfactory mating
      preference is governed by two linked genes in the region of H-2, one for the
      female signal and one for the male receptor. These mating preferences could in
      natural populations serve the purpose of increasing the representation of
      particular H-2 haplotypes or of maintaining heterozygosity of genes in the region
      of H-2.

PMID- 1032894
TI  - High-pouch imperforate anus treated by electromagnetic bougienage and subsequent
      perineal repair.
AB  - Four male infants with imperforate anus were treated by electromagnetic
      bougienage and subsequent perineal anoplasty with division of rectourethral
      fistula. Each had high-pouch imperforate anus of the supralevator type, with
      rectourethral fishtula at or above the level of the membranous urethra. Perineal
      anoplasty was accomplished in all four, with division of the rectourethral
      fistula, avoiding the need to do a sacral-abdominal-perineal procedure, as had
      been customary previously in similar cases.

PMID- 1032895
TI  - Pharmacokinetics of chlorpromazine-induced miotic response in rabbits.
AB  - The time variation of changes in the chlorpromazine-induced pupil diameter
      decrease was studied following varying bolus and slowly infused intravenous doses
      administered to rabbits. The observed pharmacological response data were
      coverted, via, the use of a dose-effect curve, to values theoretically
      corresponding to relative biophasic drug levels. These values were, in turn, used
      to construct a linear pharmacokinetic model of the drug bioavailability input
      equilibrium pharmacological response output dynamics of the system. The use of a
      time domain, MULTIFIT, computerized method of fitting the data to obtain a
      pharmacokinetic model was compared to the use of a frequency response, PLTEST,
      approach. The fidelity of the model in quantitatively relating the time course of
      systemic drug bioavailability to observed pupil response was verified by the
      satisfactory agreement obtained by directly comparing experimentally known
      amounts of drug intravenously infused with corresponding values computed from
      observed changes in pupil size. The applicability of using pharmacological data
      for quantitative bioavailability and pharmacokinetic analysis of chlorpromazine
      is demonstrated. This finding is particularly significant because no suitable
      chemical or radiological direct assay technique exists for determining levels of
      chlorpromazine, except for high doses, in body fluids.

PMID- 1032896
TI  - Humoral reponse to neuraminidase-treated tumor cells.
AB  - L1210 leukemia cells grew progressively and caused tumor deaths in all recipient
      mice. However, when these cells had been treated with Vibrio cholerae
      neuraminidase (VCN) prior to injection, tumor deaths did not occur. Both
      untreated and VCN-treated L1210 cells elicited a humoral response, as manifested
      by an increasing percent of cells in the spleen and peritoneal cavity, with
      various types of membrane-associated immunoglobulins. Progressive tumor growth
      was associated with a large percent of peritoneal exudate (PE) cells bearing
      membrane-associated IgG, a late increase in the percent of PE cells with IgG, and
      only a small percent of PE cells with IgM on their surfaces. Conversely, PE cells
      from mice given VCN-treated L1210 cells were characterized by a small percent
      with IgG, an early increase in percent of cells with IgG, and a large percent
      with membrane-associated IgM. An injection of VCN-treated L1210 cells into mice
      with progressively growing L1210 tumors caused frequent tumor remissions, with a
      corresponding alteration of the ongoing humoral responses. Both the degree of
      alteration and the number of cures depended on the tumor burden at the time VCN
      treated tumor cells were injected. The humoral response in mice with tumor
      remission following immunization was comparable to the response detected after an
      injection of VCN-treated cells only.

PMID- 1032897
TI  - Choline loss during hemodialysis: homeostatic control of plasma choline
      concentrations.
AB  - Endogenous concentrations of free choline in plasma were measured in azotemic
      subjects receiving repetitive hemodialysis and excretion of free choline into the
      dialysate was determined. Chemical choline in plasma and dialysate was measured
      by adding choline kinase and measuring the production of radiolabelled
      phosphorycholine in the presence of radiolabelled adenosine triphosphate (ATP).
      Mean free choline concentration in plasma of azotemic subjects receiving
      hemodialysis was found to be 37 muM, which is about twice that of normal persons.
      The total excretion of choline into the dialysate during 360 min averaged 730
      mumoles +/- 69 (SEM). Levels of free choline in plasma fell during hemodialysis
      at two hours but recovered toward predialysis values at six hours. The return of
      plasma choline concentrations toward control values during dialysis suggests that
      a feedback mechanism exists which was activated rapidly to produce homeostasis of
      plasma choline concentrations. In these patients, the degree of peripheral
      neuropathy as judged by measurement of nerve conduction velocities showed a
      significant inverse correlation with levels of free choline in plasma.

PMID- 1032898
TI  - New percutaneous caval filter device for pulmonary thromboembolism.

PMID- 1032899
TI  - Elemental analysis of biological specimens in air with a proton microprobe.
AB  - The unique capabilities of the proton microprobe in an atmospheric environment as
      a biological tool are illustrated in studies of arsenic and mercury distributions
      in siingle strands of hair from poisoning victims and of the distributions of
      several abundant elements in frozen hydrated eye and kidney specimens from rats.

PMID- 1032900
TI  - Atopic dermatitis and IgE. Relationship between changes in IgE levels and
      severity of disease.
AB  - At the Mayo Clinic, atopic dermatitis was evaluated in a series of 28 patients to
      determine whether, during the course of the disease, serum IgE levels fluctuated
      with changes in the severity of dermatitis. The study covered a 1- to 11/2-year
      follow-up period. Previously, it had been shown that, at initial examination,
      serum IgE levels were positively related to the extent of disease. Although
      notable fluctuations in serum IgE levels and in extent of dermatitis were seen in
      more than half of the cases, no relationship was found between the two factors
      during the period of study.

PMID- 1032901
TI  - 2-Deoxyglucose selectively inhibits Fc and complement receptor-mediated
      phagocytosis in mouse peritoneal macrophages. I. Description of the inhibitory
      effect.
AB  - Incubation of normal or thioglycollate-elicited mouse peritoneal macrophages with
      2-deoxy-D-glucose (2-dG) inhibits the capacity of these macrophages to
      phagocytize IgG- or complement-coated particles via their Fc and C3 receptors. 2
      dG has no inhibitory effect on the capacity of these macrophages to phagocytize
      latex or zymosan particles, which are ingested in the absence of specific
      opsonins, and it does not inhibit binding of IgG- or C3-coated particles to their
      respective receptors on the macrophage's plasma membrane. 2-dG exerts its
      inhibitory effect on the macrophage and not on the opsonized particle. The
      inhibition is independent of particle size, occurs within 15-30 min of addition
      of this glucose analogue to the medium at 37 degrees C, cannot be overcome by
      supra-agglutinating amounts of opsonizing antibody, and is completely reversible
      by substitution of 5.5 mM glucose for 50 mM 2-dG in the medium. Addition of
      equimolar amounts of glucose or mannose, but not of fructose, galactose, fucose,
      or glucosamine, to medium containing 50 mM 2-dG results in substantial reversal
      of the inhibitory effect of 2-dG on Fc and C3 receptor mediated phagocytosis.

PMID- 1032902
TI  - Effect of hypoxia on small vessel blood content of rabbit brain.

PMID- 1032903
TI  - An improved isolation procedure for the gas chromatographic analysis of urinary
      polyamines.
AB  - The isolation of polyamines from urinary hydrolysates in a sufficiently pure
      state for subsequent analysis by gas chromatography has proved to be difficult.
      However, by using columns of Porapak-Q and ion-exchange resins, urinary
      hydrolysates are readily purified and formation of trifluoroacetyl derivatives of
      polyamines proceeds in high yield without carryover of artifacts in the gas
      chromatographic elution profile. Good yields from the trifluoroacetylation
      reaction are not achieved if large quantities of salts or urinary pigments are
      present. By obtaining the polyamine carbonates in the final stages of the method
      described, the trifluoroacetylation reaction yields excellent derivatives of
      nanogram or microgram amounts, particularly after standing over-night at room
      temperature. The procedure described in detail should permit routine urinary
      polyamine analysis where rapidity, ease of handling many samples, freedom from
      complications and artifacts are a consideration.

PMID- 1032904
TI  - The infectivity of adenovirus 5 DNA-protein complex.

PMID- 1032905
TI  - Tay-Sachs screening: social and psychological impact.
AB  - Participants in two Tay-Sachs screening programs were generally satisifed with
      the organization of the tests and the results. There was no evidence of adverse
      impact on reproductive  plans or interpersonal relations, and the respondents
      professed to believe in the value of screening. While the carriers discussed
      their condition freely with others and were no less favorable to the idea of
      screening than the noncarriers, about one-half of their number expressed
      discomfort in being told they were heterozygotes. These feelings were allayed by
      counseling, but there was evidence of some residual unease. It is suggested that
      this anxiety would be less prominent and more easily reduced if screening were
      done under conditions of ordinary primary medical care rather than outside the
      conventional system.

PMID- 1032906
TI  - Ion dependence of the tarsal sugar receptor of the blowfly Phormia regina.

PMID- 1032907
TI  - The relation between total finger ridge-count and variability of counts from
      finger: genetic implications of racial variation.
AB  - The measure of ridge-count diversity, S/square root 10, was computed for a sample
      of American Whites, American Blacks and African Blacks, and the regression of
      S/square root 10 on total ridge-count was determined for each group. The shapes
      of the regression lines differed considerably. The American White curve was very
      similar to that obtained by Holt in an English sample, while the two Negro curves
      generally showed lower lower S/square root 10 values for ridge-counts over 80.
      The American Negro curve was found to behave like a mixture of the White and
      African Negro curve to a degree approximating to the fraction of White genes in
      their gene pool. Holt's parent-child data are used to construct a simple test of
      the hypothesis that that S/square root 10 reflects zygosity in total ridge-count
      genotypes. The preliminary results support this hypothesis.

PMID- 1032908
TI  - mRNAs containing and lacking poly (A) function as separate and distinct classes
      during embryonic development.

PMID- 1032909
TI  - Production and fate of Balbiani ring products.

PMID- 1032910
TI  - In vitro sensitization and induction of syngeneic tumor--specific cell--mediated
      cytotoxicity.

PMID- 1032911
TI  - Cellular immune deficiency in patients with glioblastoma.

PMID- 1032912
TI  - Concentration-dependent mutation of diploid human lymphoblasts by
      methylnitronitrosoguanidine: the importance of phenotypic lag.
AB  - The mutation of diploid human lymphoblasts by methylnitronitrosoguanidine (MNNG)
      was measured over the range of 0--45 ng of MNNG/ml of of medium. We found a 12
      day lag in the phenotypic expression of 6-thioguanine resistance; the occurrence
      of this lag was independent of MNNG concentration. We hypothesize that the
      unexpectedly long lag period reflects a requirement for the loss of previously
      existing molecules of the enzyme hypoxanthine-guanine phosphoribosyltransferase
      (HGPRT) after mutation at the HGPRT locus.

PMID- 1032913
TI  - In vitro synthesis of rat pre-proalbumin.

PMID- 1032914
TI  - Anti-inflammatory and anticonvulsant properties of some natural plant
      triterpenoids.

PMID- 1032915
TI  - Proton vs. electron scanning transmission microscopy: the ratio of elastic to
      inelastic cross-sections.

PMID- 1032916
TI  - Components and control of ribonucleotide reductase system of the rat.

PMID- 1032917
TI  - A model for reinforcing mental health facilities: a student's view.
AB  - Present mental health care facilities are not reinforcing either to work in or to
      utilize. A new approach to agency design, in order to provide client self-respect
      and situational relief, to increase availability and accessibility of services,
      and to attract highly skilled staff should be adopted. The criteria for a
      reinforcing agency should be based on a client, staff, and community needs.
      Changes can be implemented by building new facilities or modifying old ones. The
      resulting facilities would enhance the treatment process, reinforce behavioral
      change, and reinforce productivity.

PMID- 1032918
TI  - Diabetes mellitus: clinical features in 404 Ethiopians.

PMID- 1032919
TI  - Serum alkaline phosphatase levels of some fresh water teleosts.

PMID- 1032920
TI  - Cognitive changes during the adult years: implications for developmental theory
      and research.

PMID- 1032921
TI  - Drug deaths involving propoxyphene-an assessment in metropolitan Detroit.

PMID- 1032922
TI  - [Role of integrity of the inner nuclear membrane in energy supply for protein
      synthesis in the isolated cell nuclei of the salivary glands of Chironomus
      plumosus].
AB  - Using isolated nuclei of salivary grand cells of Chironomus plumosus larvae, it
      was revealed that the integrity of nuclei was a necessary condition for
      realization of protein synthesis in the nuclei. The involvement of nuclear
      particles in the above synthesis is supposed.

PMID- 1032923
TI  - Sheehan's syndrome with psychosis.

PMID- 1032924
TI  - [Clinical aspects of symptomatic psychoses].

PMID- 1032925
TI  - Effect of a phorbol ester on a transformation-sensitive surface protein of chick
      fibroblasts.

PMID- 1032926
TI  - Noise exposure and prevalence of high blood pressure among weavers in Iran.
AB  - 821 weavers working in three textile mills were examined in this survey. It was
      found that 8.5% of the workers were hypertensive and 12.4% borderline. All these
      rates are significantly different from those of the control groups. Also there is
      a clear increase in the prevalence of hypertensive and borderline cases in the
      weavers in relation to the length of employment. These findings emphasize the
      need for, at least annually, periodic examination of the entire work population
      in order to detect early such adverse health effects and to consider suitable
      medical care.

PMID- 1032927
TI  - Isolated regional perfusion in the treatment of soft tissue sarcomas of the
      extremities.

PMID- 1032928
TI  - The TRIC agent in the female genital tract; a cytologic and virologic study in a
      trachomatous hyperendemic area.

PMID- 1032929
TI  - Comparative efficacy of the stained blood-film and counting-chamber technique for
      the diagnosis of Wuchereria bancrofti.

PMID- 1032930
TI  - Investigations of delayed-type hypersensitivity in rabbits experimentally
      infected or sensitised by vaccinia virus.

PMID- 1032931
TI  - Intrascleral gonio-trepano-iridencleisis.

PMID- 1032932
TI  - Comparative study of the dark adaptation time in the normal Egyptians.

PMID- 1032933
TI  - Serum proteins and transferrin levels in diabetic patients.

PMID- 1032934
TI  - Pathology of Brenner tumours.

PMID- 1032935
TI  - [Properties of cardiac glycosides and their effect on the central nervous
      system].

PMID- 1032936
TI  - [Choice of the test program and a search of the meaningful indices for
      determining the work capacity of a human operator].

PMID- 1032937
TI  - [Parameter optimization of an endoscopic optical relay system containing double
      lens bonded objectives].

PMID- 1032938
TI  - [Interferon 1976. I. Interferon and regulatory systems of the organism (author's
      transl)].

PMID- 1032939
TI  - [Sector occlusion in the treatment of functional amblyopia].

PMID- 1032940
TI  - [The vertical element and the element of torsion in paralysis of the large
      oblique. 80 cases].

PMID- 1032941
TI  - [Etiology and pathogenesis of exanopsic amblyopia and ways of its prevention].

PMID- 1032942
TI  - [Exophthalmos in Crouzon's disease and in Apert's disease].

PMID- 1032943
TI  - [Acute maculopathies without fluorographic expression].

PMID- 1032944
TI  - [Diabetic nephropathies and their treatment].

PMID- 1032945
TI  - Hiatus hernia: a comparison between two methods of fundoplication by evaluation
      of the long-term results.
AB  - This paper presents a comparative study of two methods of fundoplication, a
      Belsey-like procedure and a Nissen-Rossetti operation in the management of 283
      cases of hiatal hernia from 1962 to 1974. The methods, history, and preoperative
      findings are described, and the mortality and morbidity rates, particularly
      related to recurrence, are discussed. A short historical review is included in
      the discussion, which also deals with the anatomic and physiologic factors
      thought to be involved in the maintenance of the competence of the cardia. The
      author's reasons for preferring a Nissen operation are outlined. The management
      of peptic stricture and of shortening due to periesophagitis by modification of
      this technique is described.

PMID- 1032946
TI  - Diagnostic significance of fluctuations in morning level of immunoreactive
      parathormone (IPTH) in subjects with primary hyperparathyroidism.

PMID- 1032947
TI  - Relationship between Hb and HbA2 concentrations in beta-thalassemia trait and
      effect of iron deficiency anaemia.
AB  - The relationship of HbA2 to total Hb has been measured in 204 cases of Beta
      Thalassaemia (beta-th-t) where the total Hb varied from 3.6 to 16 g/100 ml. The
      variation of total Hb in the study population was due, as far as could be
      defined, only to beta-th-t and a superimposed iron deficiency anaemia (IDA).
      Superimposed IDA decreases HbA2 proportionately more than it does total Hb (P
      less than 0.001). A not previously described relationship between HbA2 and total
      Hb was demonstrated and probably conformed to a second degree parabola.

PMID- 1032948
TI  - [Studies on the effect of nutritional factors on the rumen mucosa. 2. Report.
      Morphological conditions after feeding with fattening rations in various physical
      forms].
AB  - 3 groups of fattening cattle (DSR breed) were fed rations of nearly identical
      composition for a period of 395-455 days. The rations consisted of either crushed
      (group I), finely ground (group II) or finely ground and pelleted material (group
      III). Samples of the ruminal mucosa from 26 animals were investigated
      macroscopically, microscopically and histologically. All samples from animals of
      group I were found to be normal whereas clumping of the villi, hyperkeratosis,
      atrophy and loss of villi over 40%-50% of the surface of the ruminal mucosa were
      observed in the animals from group II, and, to a larger extent in animals of
      group III. The main reason for the mentioned changes of that kind are the very
      fine foodstuff particles, less than 0.05 to 0.5 mm in length, which form
      extraneous deposits in the mucosa or act as cement substances between
      neighbouring villi. This leads to hyperkeratosis because these particles prevent
      desquamation of the corneal cells and at the same time produce conditions of
      compression; these, in turn, result in a hardening of the newly formed stratum
      corneum. Hypertrophy of the undamaged villi was observed in animals of group III
      receiving the pelleted ration (thickness of villi group III: 243 mum as compared
      with group I:196 mum). The unfavourable morphological state of the ruminal mucosa
      in animals of group III was associated with a reduced rate of daily weight gains
      and increased food consumption.

PMID- 1032949
TI  - [Protein utilization of mixed feed rations in lactating pigs with reference to
      the essential amino acid content of the feed proteins. 3. Report. Correlation
      between the protein metabolism data and the amino acid content of the dietary
      protein].
AB  - Protein utilization data were established in N balance trials with lactating sows
      fed various dietary proteins. The data obtained were compared with the amino acid
      indices of the dietary proteins and regression equations were established for the
      relations existing between these data. Additionally, simple and multiple
      regressions were calculated for relationships between the levels of N balance and
      the levels of crude protein intake, digestible crude protein, lysine per kg of
      milk production or lysine and all the other essential amino acids per 10 g of
      milk N. A relation was found between the level of daily lysine intake and all the
      other essential amino acids and the level of productive N utilization.

PMID- 1032950
TI  - Metabolic effect of alpha-and the beta-adrenergic stimulation of rat submaxillary
      gland in vitro.
AB  - 1. Incubation of submaxillary-gland slices with isoproterenol, a beta-adrenergic
      agonist, stimulated glucose removal by 41% and decreased tissue [glucose 6
      phosphate] by 50%. Propranolol blocked these effects of isoproterenol. 2.
      Phenylephrine, an alpha-adrenergic agonist, stimulated glucose removal by 35% and
      decreased tissue [glucose 6-phosphate] by 75%. In addition, phenylephrine also
      completely overcame the inhibition of pyruvate removal caused by acetoacetate
      metabolism and decreased tissue [atp] by 45%. Phentolamine blocked the effects of
      phenylephrine. 3. In contrast with beta-adrenergic stimulation, alpha-adrenergic
      stimulation required exogenous Ca2+. 4. These results explain the different
      metabolic responses of the submaxillary gland to adrenaline in the presence and
      absence of exogenous Ca2+.

PMID- 1032951
TI  - New build and blood pressure study and observations on future investigations.

PMID- 1032952
TI  - [Changes of pulmonary function during and following anesthesia and surgery].

PMID- 1032953
TI  - The clinical manifestations of arteriosclerotic heart disease.

PMID- 1032954
TI  - Man, medicine and government.

PMID- 1032955
TI  - [Early development of gonads and the ontogenesis of rete testis and tubuli
      seminiferi recti in the chicken (Gallus domesticus)].

PMID- 1032956
TI  - [Some clinical and paraclinical observations about the syndrome of "acropathie
      ulcero-mutilante" (author's transl)].
AB  - A case of "acropathie ulcero-mutilante" is reported, some features of which
      contribute to a better knowledge of the following controversial points: a) the
      occurrence of sporadic non familiar cases; b) the existence of degenerative
      changes in the motor pathways; c) the hystochemical picture, which has been not
      previously described. This case confirm sporadicity and degenerative changes in
      motor pathways. The histochemical picture show typical signs of denervation.

PMID- 1032957
TI  - [Epidemiological study on coronary risk factors in a population of clerks in
      Parma. Methods of research and 1st results].
AB  - After a review of current literature, the AA. present the purposes and the
      methods of an epidemiological study on coronary risk factors in selected bank
      clerks of Parma, in view to correlate the dietary factors, possible methabolic
      alterations, psychical behaviour, social and environmental position and coronary
      risk evaluated by electrocardiographic stress test. In this respect, the AA.
      report and discuss, as example of the reliability and validity of the
      investigative model followed, the preliminary results observed in the 274
      subjects up to this time controlled.

PMID- 1032958
TI  - [Cystine-amino-peptidase (C.A.P.) and D.B.P. in "at risk" pregnancy with "poor
      intrauterine fetale growth" (P.I.F.G.) (author's transl)].
AB  - The normal range of serum cystine-amino-peptidase (C.A.P.) in 54 cases of
      uncomplicated pregnancies was established. 21 patients whose pregnancies were
      though to be "at risk" were serially monitored by sonar biparietal cephalometry
      and serum cystine-amino-peptidase determination. The results show that exists a
      correlation between C.A.P. and biparietal cephalometry values. Furthermore the
      "predictive power" towards neonatal conditions (by birth weight and Apgar score
      determination) was of 77,55% for the biparietal cephalometry and 76,10% for
      C.A.P.

PMID- 1032959
TI  - [Lupine, a contribution to the human food supply. 3. Nutritional physiological
      study with lupine (Lupinus albus) flour].
AB  - Lupinus albus flour doses of 58.9 +/- 9.6 g have been given to 20 persons. This
      sweet lupine flour has been digestible without complications in all cases. There
      have been no significant changes of hemoglobine, hematocrite, total protein,
      urea, bilirubine, and SGOT in the blood. So the lupine may be used for
      improvement of protein supply in men under the criteria that (1) the alkaloid
      content of the seed does not exceed 0.02%, (2) the seed itself contains no
      secondary fungi which may cause a lupinosis.

PMID- 1032961
TI  - Changing perspectives and scientific validity.

PMID- 1032960
TI  - Antibodies to spermatozoa. VII humoral and cellular aspects of sperm inmunity and
      infertility.
AB  - The occurrence of sperm antibody in serum and cervical mucus of women from
      intertile couples in the serum of their male partners, as well as cellular
      immunity to sperm, has been studied by agglutination and immobilization
      techniques. For a total of about 260 couples, the tests on serum showed that 18%
      of the women and 8% of the men were positive by the Kibrick technique and that
      15% of the women and 4% of the men were positive by the F-D technique. The women
      who were positive in their cervical mucus were 8% of the group by the K-agg
      (Kibrick agglutination) technique, 2% by the MIS-agg. (Microscale agglutination)
      technique, and 40% by the MIS-imm. (Microscale immobilization) tecnique. In
      considering all three techniques. 42% of a group of 132 women were positive.
      Cellular immunity to sperm, by the Migration Inhibition method, was positive in
      18% and zero per cent of infertile and fertile women, respectively.

PMID- 1032962
TI  - Survey of the non-emergent cases utilising the casualty and emergency department
      in three large hospitals of Delhi.

PMID- 1032964
TI  - Winds of change on Fishers Lane.

PMID- 1032965
TI  - Surgical residency planning.

PMID- 1032966
TI  - "Ischemic" heart disease in fire fighters with normal coronary arteries.
AB  - Near maximal stress testing conducted on a group (N = 90) of randomly selected
      Los Angeles City fire fighters (age 40-59 yrs.) revealed that 10% had ischemic
      ECG changes. These ischemic ECG responses were confirmed during a second test
      conducted two to four weeks after the initial test. Coronary heart disease (CHD)
      risk factor analysis revealed that in general the men were not at high risk for
      CHD. Six of the nine men elected to undergo cardiac catheterization and
      angiography. One patient had severe triple vessel disease and subsequently
      underwent aorto-coronary bypass surgery. Another had 50% obstruction in the
      circumflex branch of the left coronary while the other four men had no visable
      signs of coronary obstruction. The men with "normal" coronaries, however, did
      show signs of abnormal cardiac function during atrial pacing. One man had cardiac
      enlargement, hypokinesis, ischemic ECG and abnormal lactate metabolism. Another
      had abnormal lactate metabolism and ischemic ECG. A third man had moderate
      cardiac enlargement with anterior wall hypokinesis. The fourth had ischemic ECG
      changes with angina but otherwise normal cardiac function. All four of these men
      had pressures which were within normal limits. These data show that some fire
      fighters have "ischemic" heart disease with patent coronary arteries. This
      disease may be due to job related factors (i.e. carbon monoxide and other noxious
      fumes, catecholamines, etc.) which reduce myocardial oxygen supply or greatly
      increase myocardial oxygen demands.

PMID- 1032967
TI  - [On lactose intolerance].

PMID- 1032968
TI  - [Serum levels of uric acid in patients from general practices (author's transl)].

PMID- 1032969
TI  - [The actual age distribution of patients with carcinoma of the uterine cervix and
      its precursors (authors transl)].

PMID- 1032970
TI  - [The assessment of the adiposity by the measuring of the skinfolds (author's
      transl)].

PMID- 1032971
TI  - [Subcutaneous mastectomy. indication and technique (author's transl)].

PMID- 1032972
TI  - Treatment of painful neuromas of sensory nerves in the hand: a comparison of
      traditional and newer methods.
AB  - The results of treatment of 348 painful neuromas of sensory nerves of the hand in
      172 patients were evaluated. Three hundred and sixteen were treated by simple
      excisional neurectomy and these results may be used for comparison with other
      methods. Sixty-five percent had an excellent or satisfactory result from a single
      such procedure. A repeated neurectomy improved the results to 78 percent. The use
      of silicone rubber caps as a secondary procedure over the nerve stump in 32 cases
      did not improve the results. A technique of funicular resection with epineurial
      ligation in 45 patients with neuromas achieved about the same percentage of good
      results as did simple excisional neurectomy. The ideal treatment is not at hand
      yet, but at the present time it is recommended that treatment should consist of
      excisional neurectomy, repeated at least one if necessary.

PMID- 1032973
TI  - Reconstructive hand surgery in tetraplegia, stroke, and cerebral palsy: some
      basic concepts in physiology and neurology.
AB  - The examination of hands in tetraplegia, stroke, and cerebral palsy must include
      evaluation of the state of the ligaments the muscles available for motors for
      tendon transfer, and, most important, the areas of sensibility. The test for two
      point discrimination is the most valuable in providing information regarding both
      exteroception and proprioception. Done properly, this test provides more useful
      information than any other used currently.

PMID- 1032974
TI  - [Rickets in brain-damaged children during longtime therapy with neuroleptics and
      antiepileptics].

PMID- 1032975
TI  - [The encephalic syndrome after injury to the cervical spine in childhood].

PMID- 1032976
TI  - [Prevention of decubitus ulcer and management in the early phase of treatment in
      patients with paraplegia].

PMID- 1032977
TI  - Stress--induced gastrointestinal lesions in neonatal pigs: effects of dopamine
      and diet.

PMID- 1032978
TI  - Effect of stress on serotonin concentration and tryptophan hydroxylase activity
      of brain nuclei.
AB  - The effects of a single stressful stimulus on serotonin (5-HT) concentration and
      of repeated stressful stimuli on tryptophan hydroxylase (THy) activity were
      measured in individual hypothalamic nuclei and other rat brain regions using
      specific sensitive radioisotopic enzymatic microassays. Two h after formalin
      injection, 5-HT levels were increased in the dorsal raphe (RDN). Acute
      immobilization stress, however, reduced the concentrations of 5-HT in several of
      the hypothalamic nuclei: the medium eminence (ME), lateral amygdaloid nucleus,
      hippocampus, cingulate cortex (CCX) and RDN. Five consecutive daily
      immobilization periods failed to alter THy activity in any region examined. These
      results suggest a rapid release of 5-HT both from the cells and the axon
      terminals in the central nervous system, and failure, even with repeated
      stresses, to elicit induction of increased levels of the biosynthetic enzyme
      regulating the synthesis of the neurotransmitter.

PMID- 1032979
TI  - Pollution-reduced Kjeldahl method for crude protein.
AB  - Pollution from the Kjeldahl method for crude protein has been reduced by
      substituting a low level of copper (0.04 g CuSO4) for the mercury (0.7 g HgO)
      specified in the AOAC official method, 2.049. Adjustments were made in the salt
      acid ratio so the new system could handle hard-to-digest samples in a reasonable
      time. The new method was rugged for lysine. HCl. It is designed to be used for
      crude protein in feeds or similar Kjeldahl work. Precision and accuracy were
      equal to or better than that for the official method in a study of 17 samples
      analyzed in duplicate on 3 different days. The following samples were used in the
      study: lysine. HCl, tryptophan, NBS standards, urea, meals, mixed feeds, grains,
      and forage. The average per cent nitrogen found was 9.52 by the official method
      and 9.53 by the copper method. The average standard deviation was 0.038 by the
      official method and 0.033 by the copper method, giving the corresponding relative
      standard deviations of 0.40 and 0.35%.

PMID- 1032980
TI  - [Gonadotropic action of dichlorobutadiene in a chronic experiment].

PMID- 1032981
TI  - [Changes of potassium level in the serum and of lactic acid in whole blood
      following lysthenon injection in the horse].

PMID- 1032982
TI  - [Acupuncture analgesia in veterinary medicine].

PMID- 1032983
TI  - [Strongylus edentatus as the cause of subconjunctional phlegmon and granuloma
      formation in the horse].

PMID- 1032984
TI  - [Immunologic deficiency syndromes].

PMID- 1032985
TI  - Reflection-impulsivity and need for achievement in emotionally disturbed
      children.
AB  - Reflection-impulsivity is the cognitive dimension proposed by Kagan and his
      colleagues to describe the differences in children's resolution to response
      uncertainty. Impulsive children tend to respond quickly without considering all
      of the available alternatives and consequently make many mistakes. Reflecttive
      children consider all of the available alternatives, withhold responding until
      they have a high probability of being correct, and consequently make few
      mistakes. The primary dynamic underlying a reflective cognitive style is
      hypothesized to be a fear of making a mistake: the greater the fear, the more
      reflective the child is and the more cautiously he performs. On the other hand,
      minimal anxiety over a potentially inaccurate answer is likely to result in an
      impulsive performance.

PMID- 1032986
TI  - [Effect on glucose on levansucrase synthesis by Gluconobacter oxydans].
AB  - The effect of glucose on synthesis of levansucrase was studied with Gluconobacter
      oxydans L-1. Glucose added to the nutritional medium containing sucrose was found
      to supress its degradation by G. oxydans L-1. At the same time, the lag phase
      became shorter. Synthesis of levansucrase was inhibited in the nutritional medium
      containing glucose while the enzymatic activity increased proportionally to the
      amount of bacterial biomass in the medium containing sorbitol. Addition of
      glucose to the nutritional medium containing sorbitol prior to inoculation
      results in a decrease of the differential rate of levansucrase synthesis. The
      repressory effect of glucose on the enzyme synthesis manifested itself most
      distinctly at its addition to the culture in the period of bacterial
      multiplication with the maximum rate.

PMID- 1032987
TI  - [Surgical treatment of early and late complications of surgery of the abdominal
      aorta].

PMID- 1032988
TI  - Immunological aspects of colorectal cancer.

PMID- 1032990
TI  - Anti-hypertensive action, time of onset and effects on carbohydrate metabolism of
      labetalol.
AB  - 1 Seventeen men, aged 45-57 yr, with essential hypertension showed obvious and,
      in the standing position, dose-related reductions in blood pressure during
      treatment with oral labetalol with weekly dose increments. 2 Pulse rate changes
      were not related to dose but reduced compared with pre-treatment values. 3 No
      postural hypotension was recorded indicating lack of a dominant alpha
      adrenoreceptor-blocking component. 4 There was a small increase in mean fasting
      blood glucose levels during labetalol treatment but no alteration in insulin
      activity or response to an oral glucose tolerance test.

PMID- 1032991
TI  - Isolation and translation of calvaria procollagen messenger ribonucleic acids.
AB  - Procollagen messenger ribonucleic acid (mRNA) was isolated from the calvaria of
      15-day-old chick embryos by chromatographing total RNA over oligo(dT)-cellulose
      two times, and then fractionating the twice-bound RNA on 85% Me2SO/0-20% sucrose
      gradients. When analyzed on 99% formamide gels, the 27-30S fraction had three
      sharp fluorescent bands, one corresponding to 27S ribosomal RNA (rRNA), the
      others having mobilities lower than 27S corresponding to molecular weights of 1
      700 000 and 1 800 000. In wheat-germ, cell-free extracts, the 27-30S fraction
      directed the synthesis of two prominent collagenase sensitive polypeptides with
      mobilities corresponding to the calvaria pro-alpha chain markers. Twelve percent
      of this [3H]proline-labeled, wheat-germ product could be hydroxylated with prolyl
      hydroxylase.

PMID- 1032992
TI  - Fluorescence energy-transfer measurements between the calcium binding site and
      the specificity pocket of bovine trypsin using lanthanide probes.
AB  - Using fluorescence energy-transfer experiments we have measured the distance
      between the specificity pocket and the calcium ion binding site of bovine
      pancreatic trypsin. Proflavin and thionine were used to block the specificity
      site, whereas various lanthanide ions were substituted for the calcium. It was
      then possible to choose various donor-acceptor pairs which exhibit suitable
      energy transfer. We have calculated the distance between proflavin and Nd(III),
      Pr(III), and Ho(III) to be 10.9, and 10.3, and 10.3 A, respectively. This agrees
      very well with the value of approximately 10 A we obtained between the methyl
      protons of p-toluamidine (a competitive inhibitor) and Gd(III) using nuclear
      magnetic resonance techniques (Abbott, F., Gomez, J.E., Birnbaum, E.R., and
      Darnall, D.W. (1975), Biochemistry 14, 4935). This is strong evidence that, in
      solution, the calcium binding site is composed of the side chains of Ser-190 and
      Asp-194.

PMID- 1032993
TI  - Incorporation of macromolecules in microparticles: preparation and
      characteristics.
AB  - Macromolecules can easily be incorporated in microparticles of polyacrylamide by
      copolymerization with acrylamide in a water-in-oil emulsion. The microparticles
      preferably arount 1-3 mum in diameter, will have a macroporous structure formed
      by the polymeric network. The amount of incorporation of the macromolecules will
      depend on the structure of the network, which, in turn, will depend on the total
      amount of monomer (T) and the relative amount of cross-linking agent (C) in the
      monomeric solution. Two mechanisms are responsible for the incorporation; all
      macromolecules are, independently of the size, fixed in the threads of
      polyacrylamide and large ones are entrapped within the network formed by the
      threads. The amount entrapped will depend on the size of the macromolecule and
      the mean pore radius of the gel. In microparticles with a total concentration of
      monomers of 8% and a cross-linking of 25% (T-C=8-25) the biological properties of
      incorporated macromolecules are retained, due to the macroporous structure, as
      found in binding studies with albumin. The density of the particles will also
      depend on C and T and, to some extent, on the protein concentration. Due to the
      fixation in the polyacrylamide threads, some of the incorporated macromolecules
      will be exposed on the surface, allowing them to react with, for instance, cells,
      which cannot penetrate the particles. The optimal conditions for the
      incorporation of macromolecules in the microparticles are investigated.

PMID- 1032994
TI  - Separable binding proteins for retinoic acid and retinol in bovine retina.
AB  - Binding proteins for retinoic acid and retinol were separated from a supernatant
      prepared from bovine retina. Fraction IV from DEAE-cellulose chromatography bound
      exogenous [3H] retinoic acid which could not be effectively displaced by retinol,
      retinal, retinyl acetate or palmitate, but which was readily displaced with
      excess retinoic acid. [3H] Retinol was bound by fraction V from DEAE-cellulose
      chromatography and was not displaced by retinal, retinoic acid, retinyl acetate
      or retinyl palmitate, but was readily displaced by excess retinol. Unlike bovine
      serum retinol-binding protein, neither intracellular binding protein formed a
      complex with purified human serum prealbumin. The supernatant from bovine retinas
      was estimated to contain five times more retinoic acid binding than retinol
      binder.

PMID- 1032995
TI  - A labile acid phosphatase isozyme associated with the surface of vegetative
      Dictyostelium discoideum cells.
AB  - A minor acid phosphatase isozyme (acid phosphatase I) of vegetative Dictyostelium
      discoideum amebae has been shown to be associated exclusively with the external
      surface of the plasma membrane. The isozyme is not present in phagocytic vacuoles
      isolated with latex beads. The isozyme disappears from cells removed from
      nutrient medium and does not reappear during differentiation. When inhibitors of
      protein synthesis (e.g. cycloheximide, chloral hydrate, concanavalin A) are added
      to cells growing in nutrient medium, acid phosphatase I is rapidly lost. It
      appears that the level of protein synthesis need only be moderately reduced (less
      than 25%) to induce loss of enzyme activity. Treatment with inhibitors of DNA and
      RNA synthesis for up to 2 h had no effect on isozyme activity. It is postulated
      that the cells are able to "sense" (through the reduction in levels of protein
      synthesis) when external conditions become unfavorable, and immediately respond
      by reducing the activity of enzymes involved in maintaining contact with the
      extracellular environment. The closed system thought necessary for
      differentiation would then be created.

PMID- 1032996
TI  - Structural characterization of a glycoprotein cellulase, 1,4-beta-D-glucan
      cellobiohydrolase C from Trichoderma viride.
AB  - A glycoprotein enzyme, 1,4-beta-D-glucan cellobiohycrolase (EC 3.2.1.91) form C,
      was purified to electrophoretic homogeneity by a procedure which permitted
      isolation of gram quantities from a commercial Trichoderma viride culture
      filtrate preparation. Purified cellobiohydrolase C has an E1%/280 nm = 14.2 and
      degrades both microcrystalline and phosphoric acid-swollen cellulose to
      cellobiose. The cellobiohydrolase C contains 26.4, 4.8, 2.4 and 3.4 mol of
      mannose, glucose, galactose and glucosamine, respectively, per mol of enzyme
      (molecular weight, 48 400). Methylation analysis of cellobiohydrolase
      glycopeptides indicates an average carbohydrate chain length of two residues.
      Alkaline borohydride treatment of cellobiohydrolase C released neutral
      carbohydrate which is bound through an average of 16.7 O-glycosidic linkages to
      serine and threonine per molecule of enzyme. Glucosamine was not released from
      the protein by alkaline treatment. Analysis of alkaline borohydride-released
      carbohydrate by high pressure liquid chromatography demonstrated that an average
      enzyme molecule contains 8.8 mono-, 1.8 di-, 4.6 tri-, 1.2 tetra-, and 0.4
      pentasaccharide chains. The linkages between the neutral monosaccharides are (1
      leads to 6) as shown by gas chromatography - mass spectrometry of partially
      methylated residues. The (1 leads to 6) linkage is consistent with the stability
      of the linkages to alkaline conditions and the destruction of all neutral
      carbohydrate by periodate. Action of alpha-mannosidase indicates that some
      oligosaccharide chains contain alpha-mannose as the terminal residue.

PMID- 1032997
TI  - Resonance Raman spectra of chloroperoxidase.

PMID- 1032998
TI  - Phospholipids of Semliki Forest virus grown in cultured mosquito cells.
AB  - The phospholipids of Semliki Forest virus grown in mosquito cells (Aedes
      albopictus) were analyzed radiochemically. The ratio of 32P-labeled phospholipids
      to total 32P-label in the virus grown in mosquito cells equilibrated with
      radiophosphorus was 0.558 +/- 0.021. This value was similar to the lipid
      phosphorus: total phosphorus ratio (0.539 +/- 0.025) of the virus grown in the
      BHK cells. It is concluded that an average virion of the two types of Semliki
      Forest virus contains approximately the same number of phospholipid molecules.
      Phosphatidylethanolamine (62%), phosphatidylcholine (14%), phosphatidylserine
      (10%) and the ethanolamine analogue of sphingomyelin, ceramide
      phosphoethanolamine (9%) were the principal phospholipids in the mosquito cell
      grown virus. Comparison with the lipids of virus grown in hamster cells (BHK
      cells) revealed that two-thirds of the polar structures were dissimilar. Surface
      labeling with formylmethionyl [35S] sulfone methylphosphate suggests that a
      relatively large fraction of ceramide phosphoethanolamine is located in the outer
      half of the lipid bilayer of the viral membrane.

PMID- 1032999
TI  - Translation of tubulin messenger ribonucleic acid.
AB  - Tubulin messenger RNA has been partially purified from embryonic chick brain.
      This messenger has been shown to be polyadenylated and capable of directing
      tubulin synthesis in an heterologous cell-free protein synthesizing system.
      Phosphocellulose fractions of IF-3 derived from embryonic leg muscle or brain
      were tested for their effect on tubulin and myosin synthesis in vitro.
      Phosphocellulose fraction four from either tissue source stimulates tubulin
      synthesis three fold. Myosin synthesis is enhanced significantly only by the
      muscle subfraction. This result suggests the existence of specific factors in
      muscle for the translation of the myosin messenger.

PMID- 1033000
TI  - Primary cultures of rat aortic media: a growth stop phenomenon different from
      contact inhibition.
AB  - Cultures have been made from explants of thoracic aortas to study the growth
      pattern of aortic mediacytes. Explants from aortas of eight rats, aged between
      seven to eight weeks, were seeded. Three parameters were measured weekly from the
      second to the nineth week: the surface of the culture (S); the relative increment
      of this surface (delta S/S) and the number of 3H-thymidine labelled cells by the
      unit surface (n chi S-1) after autoradiography. The surface of primary culture,
      in relation to time, has roughly the shape of a sigmoidal curve. Growth is
      continuous until the fifth week and reaches a plateau beyond that time. The two
      other parameters decreased regularly during the first phase to attain a minimum
      at the beginning of the plateau-period; however new cells in the S-phase are
      still found in this second period.

PMID- 1033002
TI  - Introduction and history of position statement on the insanity defense for the
      proposed Federal criminal code.

PMID- 1033001
TI  - [Changes in the incorporation of labelled amino acids into proteins and
      homogenates of the brains of rats that have suffered acute hypoxia in the
      antenatal period].
AB  - The authors studied C14-leucine and S35-methionine incorporation into the brain
      tissue homogenates and protein from different parts of the brain of rats
      subjected to intrauterine hypoxia. Depression of protein synthesis in certain
      brain structures, particularly in the hyppocampus was observed alongside with the
      stimulation of the amino acid incorporation into proteins of the other parts of
      the brain. Changes of the amino acid penetration into tissue homogenates fialed
      to correlate with the rate of their incorporation into proteins in separate
      structures of the brain. Experimental results pointed to disfunction in the
      protein metabolism intensity and in the blood-brain barrier system occurring
      during the late ontogenesis in rats surviving the intrauterine hypoxia.

PMID- 1033003
TI  - [Significance of the endodermal sinus tumor (Teilum) and of simplified teratoma
      of vitelline determination].
AB  - The histogenesis of yolk-sac tumors has been explained by a selective cloning for
      extra-embryonic entoblast amongst totipotent carcinoma stemcells. The diverses
      appearances of the tumor growths are expressed mainly in the range of cyto
      differentiations of entoblastic tissue rather than in their ability to form
      structures which mimick the yolk-sac. The process is clearly apparent in
      embryoids which are becoming disorganized and during the course of experimentally
      induced mouse parietal endodermal carcinoma. The latter's appearance is strong
      evidence that the laws of specificity are obeyed. Human tumors should be analyzed
      through human embryology. Some paradoxical aspects emerge occasionally due to the
      angiogenesic capabilities of the neoplastic vitelline tissue, and to the
      correlations of this tissue with the stromal vascular response.

PMID- 1033004
TI  - Feedlot manure top dressing for irrigated pasture: good agricultural practice or
      a health hazard?
AB  - Top dressing a spray-irrigated pasture of orchard-grass with 125 t/ha of
      overwintered beef feedlot manure almost doubled the yield of dry forage: 6353
      kg/ha vs. 3578 kg/ha for the plots receiving no manure. Even at this rate of
      application, the manure did not contaminate the irrigated grass with
      enteropathogenic bacteria after irrigation. When the grass became contaminated
      through the use of fecally polluted irrigation water, the fecal coliforms,
      indicator organisms with survival characteristics similar to the salmonellae,
      were effectively eliminated from the grass after exposure to 65 hr of bright
      sunlight.

PMID- 1033005
TI  - Laboratory tests for usability of the entomophilic nematodes Steinernematidae
      Chitwood et Chitwood 1937 in biological control of some noxious arthropods.

PMID- 1033006
TI  - Periodic and traveling wave solutions to Volterra-Lotka equations with diffusion.

PMID- 1033007
TI  - On some Markov models of certain interacting populations.

PMID- 1033008
TI  - Provocative issues in psychiatric diagnosis:a dialogue.

PMID- 1033009
TI  - New protein sources.
AB  - The question whether there is a real need for more protein is first critically
      reviewed and the two main ways of making more protein available are then exposed.
      They comprise the more efficient use of the protein already available and the
      synthesis of new protein. The possibilities offered by the oilseeds are then
      briefly expounded and the difficulties encountered in their practical application
      are evaluated. The texture meat-like products based on extruded soya and the more
      sophisticated spun fibers are mentioned. Protein synthesis using yeast, bacteria
      and algae as microorganisms is then described. The single-cell protein (SCP)
      products obtaine on different substrates (paraffins, alcohols or inorganic
      substrates) are evaluated as regards their general composition, amino acid
      content and nutritive value. The problems of wholesomeness and tolerance are
      briefly touched upon and the development of three generations of SCP products is
      envisaged, each having a higher degree of purity and being more suited as a food.
      Finally the prospects of SCP as human food are discussed.

PMID- 1033010
TI  - Assessing inter-rater reliability for rating scales: resolving some basic issues.
AB  - This paper extends the recent work of Hall (1974) by presenting the minimal
      sample sizes and the specific linear agreement weights required for assessing the
      reliability of rating scales commonly used in neuropsychiatric and other clinico
      medical settings. The weights are shown to vary as a function of (a) whether or
      not the rating scale contains a point of 'absence', and (b) the number of ordinal
      points on the scale.

PMID- 1033011
TI  - The urethral pressure profile recorded by means of CO2-perfusion at high flow
      rates.
AB  - The urethral pressure profile (UPP) is recorded by CO2-perfusion of the urethra
      at a rate of 120 ml/min. The curves are reproducible. Their features are
      practically identical with the shape of profiles written by liquid perfusion. The
      curves are absolutely calibrated. High flow perfusion and calibration make it
      possible to compare CO2-curves with each other and even with graphs executed by
      other methods.

PMID- 1033012
TI  - Regional variations in need for and provision and use of child health services in
      England and Wales.
AB  - An analysis of indicators of the need for and provision and use of child health
      services in the 15 pre- 1974 hospital board regions in England and Wales showed
      that need and provisions were badly matched. There was a high degree of
      correlation between the indices within each of the three groups, indicating that
      a region with a small provision in one area of child health services would tend
      to have few resources in other areas also. Statistics on the use of services
      relate more to the provision of those services than to the need for them. Regions
      with large resources will justify these resources by claiming that their use
      statistics indicate needs, whereas they really indicate met demands. It is more
      important to identify demands and needs that are not being met.

PMID- 1033013
TI  - Pets and asthma.

PMID- 1033014
TI  - Cervical hostility.

PMID- 1033015
TI  - Gonorrhoea in women and exposure to risk.
AB  - Data are presented on the characteristics of women with newly diagnosed
      gonorrhoea who attended Lydia Clinic, St. Thomas' Hospital, during a 6-month
      period. Although gonorrhoea in women is largely asymptomatic, there was strong
      circumstantial evidence to suggest that some women had attended because they had
      been exposed to risk. The proportion of women thus motivated was largest among
      those women who had attended a clinic for sexually transmitted diseases before-
      in which up to 40 per cent. of women had apparently attended entirely of their
      own accord. Women born in the West Indies differed from their counterparts born
      in the United Kingdom in three respects: they were younger, recorded fewer
      contacts, and referred themselves less frequently to the clinic for a first
      visit. Implications for health education and for future research are discussed.

PMID- 1033016
TI  - Dermatophilus congolensis. A bacteriological, in vitro antibiotic sensitivity
      andhistopathological study of natural infection in Sudanese cattle.

PMID- 1033017
TI  - Observations on staphylococcal strains with reference to impedin and mastitis.

PMID- 1033018
TI  - Isospora felis and I. rivolta infections in cats induced by mouse tissue or
      oocysts.

PMID- 1033019
TI  - Ethanolic fermentation of glucose by Torulopsis glabrata in the stomachs of
      neonates of the horse, dog, goat and Soay sheep.

PMID- 1033020
TI  - Neuroanatomic projections related to biting attack elicited from ventral midbrain
      in cats.
AB  - A single electrode was implanted in each of ten cats at a point in the ventral
      midbrain from which nonaffective biting attack on a rat could be elicited by
      electrical stimulation. A lesion was then made which was just large enough to
      eliminate the elicitation of attack at suprathreshold intensities from that
      electrode. After post-lesion survival times of 3-14 days the cats were
      sacrificed, and the degeneration resulting from the lesions was followed with the
      use of modified Nauta silver stains. Four additional cats were used as anatomic
      controls. Degenerating fibers were observed to descend bilaterally through the
      midbrain, pontine, and medullary tegmentum to the vicinity of the principal
      sensory and motor nuclei of the trigeminal nerve. There was, in addition,
      evidence of degenerating terminals within the nucleus of the facial nerve and the
      spinal nucleus of the trigeminal nerve. Of particular note was the observation
      that the degenerating fibers in the region of the nucleus of the spinal tract of
      the trigeminal nerve terminated in glomeruli in the rostral portion of the
      nucleus. Degenerating fibers ascending from the lesion were found to course along
      the medial forebrain bundle into the hypothalamus and the midline thalamus in a
      pattern very similar to that previously demonstrated after lesions of biting
      attack sites in the hypothalamus. The role that the neural pathways associated
      with ventral midbrain attack sites might play in the mediation of behavior
      patterns which are elicited during attack stimulation was discussed and it was
      concluded that the demonstrated neural pathway could provide a cogent explanation
      for some of the properties of centrally elicited attack behavior.

PMID- 1033021
TI  - The stress-dependent nature of apomorphine hyperthermia.

PMID- 1033022
TI  - Comparison of changes in tryptophan and serotonin in regions of the hamster and
      the rat brain over a twenty-four hour period.
AB  - Groups of male golden hamsters and Sprague-Dawley rats were sacrificed at 4-h
      intervals over a 24-h period. Tryptophan and serotonin (5-HT) were measured in
      the telencephalon and brain stem and tryptophan was measured in serum. Highly
      statistically significant changes in tryptophan and 5-HT content were observed
      over the period of the day. Generally the changes were more clearly defined and
      were significant to a higher statistical level in the hamster than in the rat.
      Statistically significant changes were also observed in serum tryptophan. In the
      hamster the daily changes in serum tryptophan were coincidental with similar
      changes in tryptophan and 5-HT in the brain stem and tryptophan in the
      telencephalon. On the other hand, the changes in 5-HT in the hamster
      telencephalon were not well correlated with changes in tryptophan and serum
      tryptophan.

PMID- 1033023
TI  - The effect of electrophoretically applied GABA on cultured dissociated spinal
      cord and sensory ganglion neurones of the rat.

PMID- 1033024
TI  - Impaired retention of visual discriminated escape training produced by subseizure
      amygdala stimulation.
AB  - These experiments examined the effects on memory of posttrial, subseizure,
      electrical stimulation of the amygdala. Rats were trained in a visual
      discriminated avoidance Y-maze. Each animal received 6 tirals on the training
      day. Retention, tested the following day, was measured both by the number of
      correct choices on the first 6 retraining trials and by the number of trials to a
      criterion of 5 of 6 correct choices. If administered 2 min, 1 h, or 4 h, but not
      10 h, after training, bilateral amygdala stimulation significantly impaired
      retention as measured 24 h after training. In a second experiment, rats received
      unilateral amygdala stimulation in order to examine better the anatomical
      localization of effective stimulation sites. The unilateral stimulation was
      administered either 2 min, 10 min, 1 h, or 4 h after training. The behavioral
      procedures were the same as those used in the first experiment. For animals
      stimulated 2 min after training, the optimal stimulation region was one which
      extended rostrally from the ventrolateral portion of the basomedial nucleus to
      the dorsomedial region of the amygdala near the stria terminalis and nucleus
      centralis. For animals stimulated after a 10 min training-treatment interval,
      this amygdala region was not an effective stimulation site. However, in these
      animals, stimulation of the basolateral nucleus impaired later retention.
      Unilateral, posttraining amygdala stimulation administered 1 or 4 h after
      training did not appear to produce retention deficits. The findings of these
      experiments thus indicate that posttrial unilateral or bilateral amygdala
      stimulation impairs retention of discriminated avoidance training. Furthermore,
      the specific amygdala site at which posttrial stimulation impairs later retention
      varies with the training-treatment interval.

PMID- 1033025
TI  - Patterns of gastric electrical and motor activity in miniature pigs.
AB  - Gastric myoelectrical and mechanical activity was recorded in miniature pigs
      using chronically implanted electrodes and strain gauge force transducers.
      Semiautomated methods were devised to obtain quantitative evaluations of the
      electrical and mechanical parameters measured in fasted and fed animals. The
      patterns of gastric myoelectrical activity in pigs were, on the whole, similar to
      the patterns described in dogs, including regular cyclic control activity and
      spike response activity associated with muscle contraction. However, several
      points were peculiar to the species studied: conduction velocity of pacesetter
      potentials increased only moderately in the antrum; tachygastria never occurred
      in the experiments; in response to a standard meal, the frequency of pacesetter
      potentials gradually increased; mechanical activity proceeded at its maximal
      force immediately after feeding and for a long period; no evidence of 'migrating
      electrical complexes' was found in the stomach during fasting. The 40-min period
      following administration of a test meal appeared especially suitable for
      pharmacological or physiological experiments in which inhibitory factors are to
      be tested on the stomach.

PMID- 1033026
TI  - Metoclopramide hydrochloride and galactorrhea.

PMID- 1033027
TI  - Malignant transformation and natural history of oral leukoplakia in 57,518
      industrial workers of Gujarat, India.
AB  - In Gujarat, India, 6718 industrial workers, over 35 years of age, with oral
      leukoplakia (confirmed clinically and microscopically), were studied. After 2
      years, 4762 (71%) of the individuals were re-examined. The buccal mucosa was the
      most common site of occurrence; 98.3% of these individuals had oral habits, with
      smoking alone or smoking in combination with "pan" or "supari" chewing accounting
      for 74.9% of the habit forms. Six individuals (0.13%) with oral leukoplakia
      developed oral carcinomas within 2 years. This incidence of malignant
      transformation was equivalent to 63/100,000 per year, which far exceeds that of
      new oral cancers expected even in high-risk populations. While 57.3% the
      leukoplakic lesions remained unchanged during a 2-year interval, 31.6%
      disappeared and 11% had an altered appearance. This study confirmed the
      precancerous nature of oral leukoplakia.

PMID- 1033028
TI  - Treatment of malignant gliomas and brain metastases in adults with a combination
      of adriamycin, VM 26, and CCNU. Results of a phase II trail.
AB  - Forty-three patients with inoperable or recurring malignant gliomas, and 30
      patients with multiple recurring brain metastases were treated with a combination
      of Adriamycin (45 mg/m2) and 4-dimethyl-epipodophyllotoxin D-thenylidene (VM 26)
      (60 mg/m2 for 2 days) with 1-(2-chloroethyl)-3-cyclohexyl-1-nitrosourea (CCNU)
      (60 mg/m2 for 2 days). These cycles of treatment were repeated as soon as the
      hematologic restoration was complete. The treatment was well tolerated and the
      clinical condition of 31 of 43 glioblastoma patients improved during the 2 months
      after the beginning of the treatment. Six of eight patients with breast cancer
      metastases, one of 13 with bronchial cancer matastases, and three of nine with
      other types of cancer metastases also benefitted from the treatment. Examination
      of the results obtained revealed the following characteristics: 1) This
      combination had a low degree of efficiency in the treatment of metastases to
      brain, except for breast cancer metastases; 2) there was no complete correlation
      between the clinical results observed and the cinegammagraphic developments; 3)
      the results obtained were similar, independent of the initial localization; and a
      6-month median survival period was established, with 10 patients now in a state
      of apparently complete remission, 180 to 506 days after beginning of the
      treatment.

PMID- 1033029
TI  - Angiomatosis retinae. An ultrastructural study and lipid analysis.
AB  - A nonfamilial case of agiomatosis retinae (retinal hemangioblastoma) was studied
      by electron microscopy. In addition to the three major types of cells previously
      identified within the tumor (endothelial cells, pericytes, heavily lipidized
      stromal cells), fibrous astrocytes in different stages of lipidization were also
      found. The endothelial cells were fenestrated, providing the basis for the
      extravasated exudate that is characteristic of the tumor. The pericytes were
      completely surrounded by casement membranes and displayed no significant
      lipidization; in a cellular plaque of vasular tissue at the base of the lesion,
      however, some of the multilaminar pericytes showed evidence of early smooth
      muscle differentiation. The stromal cells contained abundant lipid vacuoles and a
      few organelles, and exhibited granular degeneration of cytoplasmic filaments
      between the lipid vacuoles. There was spotty basement membrane formation where
      the stromal cells abutted on the vascular elements. No interconversion could be
      demonstrated among the endothelial cells, pericytes, and stromal cells. A source
      for the stromal cells was discovered in the early lipisization of fibrous
      astrocytes. Analysis of the extracted lipid from the tumor by means of infrared
      spectroscopy, lipid chromatography, and x-ray diffraction disclosed that the
      lipid was mostly cholestrol stearate, a plasma lipid. It is suggested that in the
      retinal lesions the leaky (fenestrated) capillaries of the tumor allowed the
      passive imbibition of plasma lipid by the fibrous astrocytes, leading to their
      gradual transformation into the fully lipidized stromal cells.

PMID- 1033030
TI  - Protein cross-linking properties of the antitumor agent inosine dialdehyde (NSC
      118994).
AB  - Inosine dialdehyde (IdA), a new antitumor agent presently undergoing clinical
      evaluation in man, possesses two aldehyde groups that form stable complexes with
      a variety of biologic molecules containing amino groups. Complex formation of IdA
      with lysine, glycine, histidine, or bovine serum albumin (BSA) greatly reduces
      the cytotoxicity of IdA against L1210 leukemia in vitro. Complexes of IdA and BSA
      exhibit molecular weights ranging from 69,000 to greater than 800,000 as
      determined by Sephadex G-200 gel filtration, indicating that both aldehyde groups
      of IdA are functional and can cross-link protein molecules. The cross-linking of
      plasma proteins and the cross-linking of glycine to BSA were also observed. No
      interaction of IdA with nucleic acids, nucleic acid bases, or nucleosides was
      detected. The dialdehyde derivatives of other nucleosides also possessed cross
      linking properties.

PMID- 1033031
TI  - Competitive dihydrofolate reductase binding assay of triazinate (NSC-139105),
      methasquin (NSC-122870), and aminopterin (NSC739).

PMID- 1033032
TI  - The follicular prolactin cells of the primitive teleost engraulis japonica.
AB  - The elopiform teleost Engraulis japonica was used for a light and electron
      microscopical study of the follicle epithelium in the rostral pars distalis of
      the pituitary. In this species, which has one large follicle in the anterior
      hypophysis, there is no persistent orohypophysial duct in postmetamorphic stages.
      The apical pole of the prolactin cells is almost completely overlaid by a surface
      layer of flattened epithelial cells with a thick glycocalyx. The prolactin cells
      reach the follicular lumen through "pores" in this cell layer and at the site of
      the pore the prolactin cells bear unusual specializations consisting of one
      cilium, several tall microvilli, and a mass of granular material. Prolactin
      release takes place at the basal pole of the cells.

PMID- 1033033
TI  - Ultrastructural studies on the epithelia of the olfactory organ of cyprinodonts
      (Teleostei, Cyprinodontoidea).
AB  - The epithelia of the olfactory organ of two cyprinodontoid fish species were
      studied both by transmission and scanning electron microscopy. The relatively
      flat floor of the organ is covered by sensory and nonsensory epithelia. The
      latter is distributed in the form of bands or ridges separating distinct areas of
      sensory epithelium. Differences between the olfactory organs of the two species
      investigated related only to the topography and quantitative distribution of the
      epithelia. Their ultrastructural features are very similar. The nonsensory
      stratified squamous epithelium contains numerous goblet cells and surface cells
      provided with microridges. A hypothetical function of the microridges is
      discussed. The sensory epithelium consists mainly of basal, supporting, and two
      types of sensory cells, i.e., ciliated and microvillous receptor cells. The cilia
      exhibitapredominant 9+0 microtubule pattern. Both epithelia are covered by a
      mucus layer in which all surface structures seem to be embedded. The possible
      nature, origin, and movement mechanisms of the mucus are discussed.

PMID- 1033034
TI  - Fine structure and cytochemistry of specific granules in the lamprey atrium.
AB  - Fine structural and cytochemical studies were performed to examine the nature of
      three types of specific granules found in the atrium of lamprey; specific
      granules of the atrial muscle cell (ASG), interstitial cell granules (ICG) and
      endocardial endothelial granules (ESG). Ultrastructurally, ASG and ICG appeared
      quite similar in size, shape and electron opacity, while ESG were much larger and
      less dense in opacity than the other two. None of the granules showed positive
      DAB reaction or acid phosphatase reaction. Only ICG revealed positive chromaffin
      reaction, which agreed with formaldehyde induced green fluorescence along the
      atrial lumen. Phosphotungstic acid at low pH stained ICG and ASG strongly
      positive, and ESG weakly positive. Pronase treatment in Epon sections for 24 h
      digested ASG alone, whereas in glycol-methacrylate embedded sections, ESG were
      digested first, ASG were digested thoroughly after 30 min, but ICG were not
      digested completely after 90 min. From these results it can be concluded that the
      three types of specific granules have different constituents. ESG consist of
      protein with some polysaccharides; ASG are composed of protein carbohydrate
      complexes and lack catecholamines; ICG contain catecholamine as well as protein
      carbohydrate complexes.

PMID- 1033035
TI  - On the yolk sac of the cat. Endoderm and mesothelium.
AB  - The ultrastructure of feline yolk sacs from 11 stages between the 14th and the
      66th day is described with reference to the endoderm and the mesothelium;
      supplementary histochemical and cytochemical studies are included. Despite the
      absence of yolk, the endodermal epithelium shows a high degree of differentiation
      and activity, especially in the period between the 25th and the 38th day. Large
      stacks of RER, abundant SER, mitochondria enveloped by RER cisternae, and a
      peculiar type of lysosome are the most prominent organelles. Acid phosphatase,
      succinic dehydrogenase and NAD- and NADP-diaphorases are found with high
      activity, whereas the 17beta-hydroxysteroid dehydrogenase assay stains the
      endothelium only moderately. Indications of reabsorption are less marked. In view
      of the apparent immaturity of the liver parenchymal cells at this stage, the yolk
      sac endoderm of cat is suggested to act as an important extraembryonic site of
      biosynthesis. As preliminary results of a chemical analysis show that the yolk
      sac fluid has nearly no nutritional value, the substances synthesized are
      believed to be transported directly to the fetus. The mesothelium shows
      relatively few alterations over the period studied, is less rich in organelles
      and is obviously far less active than the endoderm.

PMID- 1033036
TI  - Studies on the ovotestis of the slug Agriolimax reticulatus (Muller).
AB  - The ovarian oocytes of Agriolimax reticulatus (Muller) have been studied by light
      and electron microscopy and electron cytochemistry. The development of the oocyte
      in the ovotestis may be divided into three stages. During Stage I the oocyte
      cytoplasm contains mainly ribosomes and also strands of endoplasmic reticulum,
      scattered mitochondria and Golgi systems. The nucleus contains both a
      paranucleolus and an eunucleolus. By Stage II the oocyte has enlarged, especially
      in a plane parallel to the basemend membrane. In addition to the above mentioned
      organelles, the cytoplasm contains lipid, glycogen and early yolk platelets.
      During Stage III, the oocyte continues to enlarge, but mainly in a plane
      perpendicular to the basement membrane. A considerable degree of cytoplasmic
      differentiation has also taken place. The plasma membrane of the oocyte has
      become specialized with the appearance of a polysaccharide-rich glycocalyx,
      microvilli and pinocytotic tubules. Elsewhere, much of the background cytoplasm,
      containing Golgi-derived, polysaccharide and acid phosphatase-rich
      multivesiculate bodies, lipid and glycogen, is sequestered by smooth membranes
      and ultimately fuses with the growing yolk platelets. The nucleus contains an
      amphinucleolus, characteristic of many gastropods. The findings of this study are
      discussed in relation to results from other studies on oogenesis.

PMID- 1033037
TI  - Transformation of cytoplasmic actin. Importance for the organization of the
      contractile gel reticulum and the contraction--relasation cycle of cytoplasmic
      actomyosin.
AB  - (1) Within the low viscous flowing endoplasm of Physarum polycephalum a
      considerable amount of actin is in the non-filamentous state. This can be
      demonstrated by applying poly-L-lysin to surface spreads of native protoplasm.
      (2) It has been shown that in protoplasmic drops the endoplasm-ectoplasm
      transformation is accompanied by an actin polymerization from the non-filamentous
      state to F-actin. (3) The actual state of the labile G-F-actin equilibrium
      determines the varying consistency (viscosity) of the cytoplasm. (4) Increasing
      viscosity can be interpreted as being brought about by a) shifting of the G-F
      actin equilibrium to the filamentous side, and (b) increased myosin-mediated
      binding sites between actin filaments. (5) Polymerization and depolymerization
      processes are involved in the rhythmically occurring contraction-relaxation cycle
      of cytoplasmic actomyosin in Physarum. (6) Cytoplasmic actin and myosin represent
      the architectural proteins of the contractile gel reticulum in eukaryotic cells.
      (7) The importance of the regulation of actin polymerization as a basic control
      mechanism of the eukaryotic cell is discussed.

PMID- 1033038
TI  - Dictyostelium 17S, 25S, and 5S rDNAs lie within a 38,000 base pair repeated unit.
AB  - Mapping with the restriction enzymes Sal 1 and R1 has generated a picture of the
      organization of Dictyostelium ribosomal DNA. The DNA which codes for 17S and 25S
      ribosomal RNAs is located within a stretch of repetitive DNA at least 38,000 base
      pairs long. This repeated unit includes 5S DNA, linked to 25S DNA. Two techniques
      were especially useful in the mapping: "cloning" 14S + 25S DNA on the plasmid
      pMB9 to amplify individual R1 fragments, and digesting DNA with R1 in the
      presence of the antibiotic distamycin A to produce specific partial digestion
      products.

PMID- 1033039
TI  - Release of RNA--DNA-protein complex during differentiation of the water mould
      Allomyces arbuscula.
AB  - A correlation between release of a nucleic acid protein complex into the external
      medium and sporangial differentiation was found. Conditions preventing
      differentiation also stopped the release. Lethal lysis is not involved in this
      release process. Extracellular nucleic acids are very heterogenous, consisting of
      nucleotides as well as acid-precipitable nucleic acids. RNA was found to be
      associated with proteins and a hetero-duplex RNA--DNA associated with this
      nucleoprotein. Some speculations are presented about possible correlation between
      the release of nucleoprotein complexes and the intracellular events of
      differentiation.

PMID- 1033040
TI  - Cell specific activity of trehalose-6-phosphate synthetase during differentiation
      of Dictyostelium discoideum.
AB  - Trehalose-6-P synthetase activity was low at the beginning of the life cycle of
      Dictyostelium discoideum, reached maximum activity at 20 h, and decreased at late
      sorocarp. Enzyme activity in developing spore cells increased 10-fold during
      differentiation from myxamoebae (0 h) to the culmination stage (20 h) and
      decreased slightly at sorocarp (24 h). Activity was similar in spore cells at the
      apex of the stalk. The activities in the stalk cells were dependent upon their
      position in the developing stalk. There was a decreasing gradient of activity
      from the apex to the base of the stalk.

PMID- 1033041
TI  - Clones of Friend leukemia cells: differences in karyotypes and responsiveness to
      inducers of differentiation.
AB  - Several clones of Friend leukemia cells have been established which differ in
      their chromosome composition. These cells also vary with regard to their
      responsiveness to DMSO, whereas all are responsive to butyric acid. Hence, there
      appears to be independent assortment of the ability of a cell line to respond to
      DMSO and to butyric acid, suggesting a different mechanism of action for each
      agent. Further, individual Friend cells possess the ability to simultaneously
      contain chloroacetate esterase and heme--two biochemical properties which have
      previously been believed to be mutually exclusive.

PMID- 1033042
TI  - [Enteral allergy to cow milk as a cause of malabsorption syndrome].

PMID- 1033043
TI  - [Metabolism in the newborn infants of diabetic mothers during the 1st days of
      life].

PMID- 1033044
TI  - Microbial metabolism of N-methylcarbamate insecticide. IV. 1 New metabolites of o
      sec-butylphenyl N-methylcarbamate by Cladosporium cladosporioides.

PMID- 1033045
TI  - A deuterium nuclear magnetic resonance study of the condensing effect of
      cholesterol on egg phosphatidylcholine bilayer membranes. I. Perdeuterated fatty
      acid probes.
AB  - Deuterium nuclear magnetic resonance quadrupole splittings Dq and the related
      acyl chain segmental order parameters Smol have been determined for
      perdeuteriostearic acid intercalated as a molecular probe in the lamellar liquid
      crystalline phase of egg yolk phosphatidylcholine-cholesterol-water mixtures. The
      2H NMR data show that cholesterol induces a high degree of order in the acyl
      chains of the phospholipid while maintaining the general profile of high order
      near the head group and relatively low order in the middle of the bilayer. This
      results in a pronounced thickening of the bilayer and concomitant decrease in the
      average molecular area of the fatty acyl chains. The giometrical changes in the
      bilayer due to cholesterol are discussed in terms of trans-gauche isomerization
      in the fatty acyl chains. The picture of the condensing effect revealed by 2H NMR
      is consistent with that from previous X-ray diffraction experiments. No evidence
      for a specific complex between cholesterol and phosphatidylcholine is apparent.
      The condensing effect of cholesterol is attributed to interaction between the
      fatty acyl chains and the rigid steroid nucleus, and to solvation of the 3beta
      hydroxyl group at the aqueous interface.

PMID- 1033046
TI  - Subaortic obstruction after the use of an intracardiac baffle to tunnel the left
      ventricle to the aorta.
AB  - Postoperative hemodynamic studies in five patients document subaortic obstruction
      after surgical repair utilizing an intracardiac baffle to establish continuity
      between the left ventricle and the aorta. Four of the patients had a Rastelli
      procedure for D-transposition of the great arteries with a ventricular septal
      defect and pulmonary stenosis; one patient had repair of double outlet right
      ventricle with a ventricular septal defect and pulmonary stenosis. The left
      ventricular outflow was shown to be a long narrow tunnel by angiography in four
      of five patients and by echocardiography in one patient. Resting aortic peak
      systolic pressure gradient ranged from 10 to 42 mm Hg (mean 24). The obstruction
      was localized to the proximal end of the left ventricule to aorta tunnel (i.e.,
      at the site of ventricular septal defect) in five patients. One patient with a
      gradient of 42 mm Hg has angina and decreased exercise tolerance. Subaortic
      obstruction is a newly described sequelae after the Rastelli procedure for
      transposition or repair of double outlet right ventricle. The obstruction may be
      hemodynamically significant and should be searched for at postoperative cardiac
      catheterization.

PMID- 1033047
TI  - Current status of porcine heterograft prostheses: a 5-year appraisal.
AB  - Between 1970 and 1975, 234 porcine heterograft valve prostheses were implanted in
      193 patients with 12 operative (6%) and 21 late deaths (11%). Detailed
      hemodynamic studies were made 6 months to 1 year following operation in 72
      patients. Mean atrioventricular (A-V) diastolic pressure gradients averaged 5.2
      mm Hg for 29 mm heterografts and 2.3, 2.5, and 2.7 mm Hg for 31 mm, 33 mm, and 35
      mm heterografts, respectively. In 10 patients with aortic prostheses peak
      systolic gradients averaged 16 mm Hg at rest (range 0-26) but increased to 70 mm
      Hg during exercise (range 20-125). Anticoagulants were not used except when
      intracardiac clot was present at operation. There were 12 systemic arterial
      emboli, all with mitral prostheses and low cardiac output; nine patients were in
      atrial fibrillation and three were in sinus rhythm. Three patients evidenced late
      tissue failure. Hydraulic function in the A-V position is excellent: prosthetic
      valve size is not limited by tertiary orifice and A-V anulus accepts large
      prosthesis. The patient's anulus is the determinant of aortic prosthesis size;
      heterograft internal diameter to outside diameter ratio is suboptimal and
      hydraulic function of the aortic prosthesis is marginal. In our clinical practice
      we consider the performance characteristics of currently available valves in
      relation to the individual patient's priorities to select an appropriate
      prosthesis.

PMID- 1033048
TI  - Actuarial comparison of Hancock porcine and prosthetic disc valves for isolated
      mitral valve replacement.
AB  - From July 1970 through December 1974, 109 patients underwent isolated mitral
      valve replacement (MVR). A Harken prosthetic disc valve (DVR) was used in 53
      patients and glutaraldehyde-preserved Hancock porcine xenograft (PVR) in 56
      patients. The functional class, distribution of mitral valve pathology, and
      incidence of atrial fibrillation were similar in both groups. There were no
      operative and three (5.5%) late deaths in the PVR group and two (3.8%) operative
      and ten (19.5%) late deaths in the DVR group. Anticoagulants were not used in the
      PVR group; there were 3 nonfatal emboli (10%), all occurring in  patients with
      atrial fibrillation and large left atria. Although anticoagulants were used there
      were 14 emboli (five in patients who died, nine nonfatal) in the DVR group
      (26.4%). In our experience, there is a significant reduction in morbidity and
      mortality, primarily from a reduced risk of thromboemboli, if a porcine valve is
      used for MVR. Anticoagulants should be used in patients with atrial fibrillation
      and enlarged left atria regardless of the type of valve used.

PMID- 1033049
TI  - Biological rhythm of cell-mediated immunity in man.
AB  - The biological rhythm of the spontaneous lymphocyte transformation and the
      lymphocyte response to phytohaemagglutinin (PHA), concanavalin A (Con A) and
      purified protein derivative of tuberculin (PPD) was studied in six healthy male
      volunteers. The count of peripheral blood lymphocytes was increasing from 08.00
      until 02.00 hr. The level of plasma cortisol was highest at 08.00 hr and lowest
      at 20.00 hr. The spontaneous lymphocyte transformation showed a biphasic cycle
      during the day; the peak values were observed at 08.00 and 20.00 hr and a
      significant depression was found at 14.00 hr. The response of peripheral blood
      lymphocytes to PHA and Con A varied inversely with the level of plasma cortisol.
      The PPD response was lowest at 08.00 hr, but the highest value was observed at
      02.00 hr. No significant day to day variation was found in any of the parameters
      studied.

PMID- 1033050
TI  - Genetic study of amobarbital elimination based on its kinetics in twins.
AB  - Following the intravenous administration of 125 mg amobarbital sodium in 7 pairs
      of dizygotic and 7 pairs of monozygotic twins, the time-course of plasma
      concentrations was observed. The number of detectable compartments varied from
      subject to subject but was consistently 1 or 2 or 3 within a given individual.
      The terminal slope of the semilogarithmic concentration-time plot (corresponding
      to biologic half-life of 22.8 hr) did not represent the elimination rate constant
      even in persons with apparently single-compartmental characteristics. The
      redistribution of amobarbital was rapid in comparison with its elimination. The
      rate of the latter (characterized by kel = 0.051 hr-1, plasma clearance = 37.7
      ml/min) could be closely identified with the rate of metabolism. The twin data
      showed that genetic control was exerted on kinetic parameters characterizing the
      rate of amobarbital elimination and, therfore, the rate of its metabolism.
      Correlation analysis suggested that this control was independent of size factors,
      which were themselves substantially heritable. The genetic analysis of twin data
      included, in addition to intracelass correlations and Holzinger's H factors,
      newly developed lower (and upper) bounds of the broad-sense heritability. In
      pharmacogenetic studies, assessment of model-independent kinetic parameters, such
      as plasma clearance with or without adjustment for body weight, is recommended.

PMID- 1033051
TI  - [Effects of sodium beta-benzalbutyrate on platelet adhesion and aggregation.
      Study on normal subjects and coronary patients].

PMID- 1033052
TI  - [Heart diseases and pregnancy. Part 3. Birth control in cardiac patients].

PMID- 1033053
TI  - [Myocardial infarct and pregnancy].

PMID- 1033054
TI  - [Obstructive cardiomyopathy associated with an ostium secondum].

PMID- 1033055
TI  - [Fetal alcohol syndrome (author's transl)].
AB  - The fetal alcohol syndrome was observed in four girls aged 1 2/12 to 9 2/12
      years, two of whom were sisters. Three of the children are older than all others
      previously described as having this syndrome. The signs consist of a decrease of
      body length and weight beginning at birth, microcephalus, marked decrease of
      intelligence and narrowing of the palpebral fissure. Frequently congenital
      cardiac defects are found and sometimes anomalies of the genitalia and other
      malformations. Experience so far indicates a causal relationship between
      considerable alcohol abuse of mothers during pregnancy and intra-uterine fetal
      damage. The prognosis is poor; in severe cases of chronic alcoholism interruption
      of pregnancy should be seriously considered.

PMID- 1033056
TI  - [Glisoxepide treatment in maturity-onset diabetics (author's transl)].
AB  - Patterns of blood glucose, serum insulin and non-esterified fatty acids (NEFA)
      were measured over a period of eight-and-a-half hours in eleven maturity-onset
      diabetics receiving 8 mg glisoxepide in the morning and 4 mg in the evening
      (while on a standard diet). The effects of administering the tablets in the
      morning with breakfast were compared to those on administering the drug half-an
      hour (five patients) or one hour (six patients) before breakfast. Although there
      was a slightly earlier increase in serum insulin when tablets were taken half-an
      hour or an hour before breakfast, different times of administration did not
      significantly affect the blood glucose or NEFA pattern. In particular, the
      extreme rise in blood glucose levels after the first breakfast could not be
      avoided.

PMID- 1033057
TI  - [Erysipelothrix endocarditis (author's transl)].
AB  - Following erysipeloid a 46-year-old man fell ill with septicaemia and
      endocarditis. Treatment with high doses of antibiotics could not prevent his
      death. Infection with Erysipelothrix rhusiopathiae in man occurs through a skin
      lesion and only rarely leads to spreading of the agent in the body presenting as
      arthritis, meningitis, or endocarditis. Erysipelothrix endocarditis is a severe
      disease leading to widespread destruction of the involved cardiac valves. The
      aortic valve is most commonly involved. 16 out of 28 patients with erysipelothrix
      endocarditis reported in the literature died, eleven of them despite treatment
      with antibiotics.

PMID- 1033059
TI  - [Metapramine: antidepressant and psycho-stimulant].
AB  - Metapramine is a new antidepressant drug. A tricyclic molecule gives it a novel
      activity in so far as its thymoanaleptic and, at the same time, psychostimulating
      actions are concerned. Quick acting, metapramine has a very interesting
      peculiarity: its large tolerance which seems to be related to a no
      anticholinergic effect.

PMID- 1033058
TI  - [Treatment of infertile women with epimestrol (author's transl)].
AB  - 155 patients have been treated with epimestrol during 593 menstrual cycles in a
      daily dosage of 5, 10 or 2.5 mg from the 1st to the 10th or from the 5th to the
      14th day of the cycle. 143 patients with secondary amenorrhoea, anovulatory
      cycles, ovulatory oligomenorrhoea, corpus luteum insufficiency, and normal cycles
      received epimestrol after an average period of 2.4 years of involuntary
      infertility. The pregnancy rate was 21% (n = 30), the spontaneous abortion rate
      13% (n = 4). Twelve further patients not seeking pregnancy were treated with
      epimestrol because of secondary amenorrhoea and (or) anovulatory bleeding. The
      results were as follows: 1) In eugonadotropic secondary amenorrhoea 8 out of 12
      patients ovulated, 5 out of 10 patients wanting children became pregnant. No
      patient with hypogonadotropism ovulated. 2) Out of 25 patients with anovulatory 
      cycles or bleeding 13 ovulated and 4 became pregnant. 3) 17 out of 68
      oligomenorrhoeic patients became pregnant. 4) In 12 out of 24 patients with
      corpus luteum insufficiency the hyperthermic phase improved and four patients
      became pregnant. 5) In 12 patients without anomalous cycles these remained
      unchanged and there were no pregnancies. 6) No side effects could be observed.

PMID- 1033060
TI  - Circulating placental lactogen levels in dairy and beef cattle.
AB  - Levels of bovine placental lactogen (bPL) have been measured in the serum of
      dairy and beef cattle and in the milk and amniotic fluid of pregnant animals with
      a highly specific radioimmunoassay. In both dairy and beef cows, serum bPL levels
      remain low (less than 50 ng/ml) during the first two trimesters and then rise
      rapidly between 160 and 200 days of gestation to a plateau. The bPL levels do not
      decline prior to parturition. During the last trimester, serum levels in dairy
      cows, 1103+/-342 ng/ml, are significantly higher than those in beef cattle, 650+/
      37 ng/ml (P less than 0.01); furthermore, dairy cows having a high milk
      production also tend to have high bPL levels. Serum levels are almost twice as
      high in twin pregnancies and are not correlated with fetal sex or birth weight.
      bPL levels in milk and amniotic fluid from dairy cattle during the last trimester
      are approximately 86% and 25% of the serum values, respectively, suggesting that
      bPL enters these fluids by passive diffusion.

PMID- 1033061
TI  - Androgens augment FSH-induced progesterone secretion by cultured rat granulosa
      cells.
AB  - Granulosa cells have been isolated from ovaries of estrogen-treated immature
      intact and hypophysectomized rats, and have been maintained in culture in a
      chemically-defined medium. Progesterone secretion by these cells was testosterone
      or 17beta-OH-5alpha-androstan-3-one (DHT), progesterone secretion was low or
      undetectable. However, the addition of testosterone or DHT together with FSH
      caused a dramatic 8- to 19-fold increase over that caused by FSH alone. On the
      other hand, luteinizing hormone (LH) alone had no effect on progesterone
      secretion, but produced a small stimulation when added together with
      testosterone. These results demonstrate synergism between androgens and FSH in
      the control of progesterone secretion by granulosa cells in culture.

PMID- 1033062
TI  - The uptake and metabolism of uridine by the slime mould Physarum polycephalum.
AB  - 1. Uridine is taken up by microplasmodia of Physarum polycephalum via a
      saturatable transport system with an apparent Km of 29 muM. An intracellular
      concentration significantly higher than that in the growth medium is attained,
      suggesting that the uptake is an active process. Both deoxyribonucleosides and
      ribonucleosides are competitive inhibitors of the uptake of uridine. 2. In
      contrast, the rate of entry of uridine into surface plasmodia is a linear
      function of the concentration of the nucleoside in the growth medium, and the
      uptake is not inhibited by other nucleosides. 3. As well as serving as a source
      of pyrimidine nucleotides for the synthesis of nucleic acids, uridine is also
      catabolised by P. polycephalum. Uracil accumulates in the growth medium and there
      is also significant conversion of C-2 of the pyrimidine ring to CO2. The
      proportion of uridine subject to catabolism in surface plasmodia is less than
      that observed for microplasmodia.

PMID- 1033063
TI  - Heterogeneity of native ribosomal 60-S subunits in Ehrlich ascites tumor cells
      cultured in vitro.
AB  - Native large ribosomal subunits in cultured Ehrlich ascites tumor cells analyzed
      by high-resolution CsCl isopycnic centrifugation consist of at least two classes
      of particles with densities of 1.57 g/cm3 (LI) and 1.59 g/cm3 (LII),
      respectively. A wash with 0.5 M KCl converts LI into particles with the density
      of LII particles. Incubation of derived large subunits (density 1.59 g/cm3) with
      0.5 M KCl wash of reticulocyte ribosomes leads to the formation of particles with
      the density of LI particles. A protein with a molecular weight of 57000 present
      in the high-KCl wash of 60-S native subunits was virtually absent in the KCl wash
      of 40-S subunits or polyribosomes suggesting that specific protein factors may be
      present on some native 60-S subunits. Possible functions of these protein factors
      are discussed.

PMID- 1033064
TI  - The requirement for tetravalency of soybean agglutinin for induction of mitogenic
      stimulation of lymphocytes.
AB  - The mitogenic activity of soybean agglutinin was found to depend on the presence
      of lectin aggregates formed in lectin preparations stored in the lyophilized
      state. Such soybean agglutinin preparations gave maximal stimulation of untreated
      pig lymph node cells and neuraminidase-treated mouse spleen cells at relatively
      high concentrations, ranging from 100 to 2000 mug/ml. After separation into
      unaggregated (divalent) and polymeric (tetra-and multivalent) fractions, it was
      found that the unaggregated lectin did not stimulate the cells, while the
      tetravalent and multivalent fractions were active and gave maximal stimulation at
      a concentration of 10 mug/ml. These results suggest that soybean agglutinin must
      have at least four sugar binding sites in order to be able to stimulate
      lymphocytes.

PMID- 1033065
TI  - The effect of short-term culture on the sensitivity of MDAY murine tumor cells
      tolysis mediated by normal rabbit serum.
AB  - Freshly explanted MDAY murine tumor cells are sensitive to lysis mediated by
      fresh normal rabbit serum. The sensitivity, which increases with the age of the
      tumor, is rapidly lost upon short-term culture, and takes place at 37 degrees C
      but not at 4 degrees C. Cellular components released into the medium during short
      term culture are capable of eliciting xenogeneic antibodies that mediate
      complement-dependent lysis of such cells.

PMID- 1033066
TI  - The relationship between storage and secretion of specific antibody by immune
      lymphoid cells: ultrastructural localization of anti-peroxidase antibodies in
      plaque-forming cells of the rabbit popliteal lymph node.
AB  - The ultrastructure of antibody-forming cells (AFC) has been studied in the lymph
      node cell population from rabbits locally immunized with horseradish peroxydase
      (PO) incorporated in complete Freund's adjuvant, and the kinetics of AFC
      development followed from day 7 to day 18 after one injection of PO. 
      Identification of the AFC was done by local hemolysis assay, using carboxymethyl
      cellulose solidifying medium and PO-coated sheep erythrocytes. AFC were
      thereafter transferred by micromanipulation into a Beem capsule, fixed, treated
      by PO for fine ultrastructure detection of anti-PO antibodies, included,
      sectioned and studied by electron microscopy. It was found that the AFC were
      essentially of three categories: lymphocytes, proplasmacytes and plasmacytes,
      with (+), or without (-), intracellular antibody. The proportion of these
      categories varies with the time elapsed since the injection of antigen and with
      the plaque-forming activity of the population: lymphocytes (-) are relatively
      more numerous (over 30%) at the early stages of immunization (day 7). The number
      of plasmacytes increases with immunization. If most of them contain intracellular
      antibody at the early stages (up to day 9), the proportion of plasmacytes (+)
      decreases markedly afterwards. The cell type distribution is compatible with the
      idea that the lymphocytes are the precursors of plasmacytes, proplasmacytes being
      transitional forms, but no direct filiation scheme can actually be deduced from
      these experiments.

PMID- 1033067
TI  - Frequency of precursor cells against the enzyme beta-galactosidase: an estimate
      of the BALB/c strain antibody repertoire.
AB  - A method has been developed for detecting anti-beta-galactosidase antibodies
      after isoelectric focusing in thin layers of polyacrylamide gel. By "staining"
      with wild-type enzyme, all antibodies against beta-galactosidase are detected,
      while a subset of antibodies able to activate a mutant enzyme is detected by
      staining with that enzyme. Limiting dilutions of beta-galactosidase-primed or
      unprimed spleen cells of BALB/c mice were transferred together with antigen into
      sublethally irradiated syngeneic hosts. The limiting role of the precursor B
      cells has been judged by the analysis of the clonal distribution of galactosidase
      specific antibodies in recipient sera. The frequency of anti-wild-type beta
      galactosidase precursor cells was one in 0.42 x 10(6) in the primed and one in
      0.93 x 10(6) in the unprimed spleen. The frequency of precursor cells for
      antibodies activating the mutant enzyme was one in 1.5 x 10(6) in the primed and
      one in 4.6 x 10(6) in the unprimed spleen. Therefore four and five times less
      anti-M (mutant) than anti-B (wild-type) precursor cells exist in the spleens of
      primed and unprimed BALB/c mice, respectively. Comparing 51 clones derived from
      one primed donor mouse, it was possible to demonstrate that at least 43 different
      mutant-beta-galactosidase-activating antibodies can be produced in one mouse.
      Comparing these 43 clones with 27 clones derived from another donor mouse, only
      one clone seemed to be common to both mice. From this the repertoire of the
      BALB/c strain has been estimated to consist of over 1000 different mutant enzyme
      activating antibodies.

PMID- 1033068
TI  - B cell tolerance induced by polymeric antigens. VI. Kinetics and reversibility of
      the inhibition of antibody-forming cells by antigen.
AB  - Injection of mice already making antibodies to 2,4-dinitrophenylated (DNP) Ficoll
      with tolerizing doses of DNP-pneumococcal polysaccharide (DNP-lys-S3) markedly
      inhibits the secretion of anti-DNP antibodies by IgM antibody-forming cells. The
      present study shows that the degree of inhibition depends not only on the dose of
      DNP-lys-S3 but also on the duration of exposure to antigen. DNP-lys-S3 was
      detectable on the surface of antibody-forming cells at a time when their rate of
      secretion was unimpaired, thus suggesting that the inhibition involves
      intracellular events subsequent to the binding of antigen to the cell membrane.
      The inhibition was reversible if antibody-forming cells were exposed to antigen
      for 24 h, and then cultured for 18 h in its absence, but became irreversible if
      the treatment period was extended to 48 h. The relevance of this model of
      inhibition of lymphocyte function by antigen to possible mechanisms of B cell
      tolerance is discussed.

PMID- 1033069
TI  - In vitro synthesis of factor B of the alternative pathway of complement
      activation by mouse peritoneal macrophages.
AB  - Factor B of the alternative pathway of complement activation was shown to be
      synthesized and secreted by unstimulated mouse peritoneal macrophages. The
      activity of B in the culture supernatants from macrophage monolayers was detected
      by consumption of C3 in reaction mixtures containing supernatant and guinea pig
      factors C3, D and insoluble C3b. Using a monospecific antiserum, factor B in
      concentrated culture supernatants was shown by immunodiffusion and
      immunoelectrophoresis to be identical to factor B in mouse plasma and to form a
      characteristic complex with cobra venom factor in the presence of D. A steady
      rate of factor B secretion was observed for 4 days providing the medium was
      changed every 24 h. Cycloheximide (0.5 mug/ml), an inhibitor of protein
      synthesis, caused inhibition (90%) of factor B production. Incubation of culture
      medium containing 14C-labeled amino acids with the macrophage monolayer resulted
      in incorporation of radioactivity into factor B as detected by autoradiography of
      precipitation lines formed with anti-B antiserum; This indicated that synthesis
      of factor B had occurred. In the same culture supernatants the presence of newly
      synthesized C3 was also demonstrated.

PMID- 1033070
TI  - Withdrawal characteristics following chronic pentobarbital dosing.
AB  - Experiments were performed to provide a quantitative description of the
      barbiturate withdrawal syndrome. Physical dependence was produced in 63 cats by
      'maximally tolerable' dosing with sodium pentobarbital. After 5 weeks of chronic
      treatment each animal was placed in an activity monitoring cage and observed
      closely for signs of barbiturate abstinence. Electroencephalographic monitoring
      of sleep--wake cycles was performed in 5 of these cats. Most withdrawal signs
      appeared in 12-18 h and rapidly intensified. These included signs of neural hyper
      excitability that involved motor, autoncidence, severity and time course of many
      withdrawal signs. 26 animals (41%) died during abstinence, usually during or
      immediately following grand mal type convulsions. The importance of quantitating
      withdrawal phenomena is discussed with respect to investigation of the
      requirements for physical dependency production, comparison of different drug
      dependencies, and pre-clinical evaluation of potential treatments of sedative
      hypnotic dependence.

PMID- 1033071
TI  - The bradykinin potentiating activity of two pentapeptides on various isolated
      smooth muscle preparations.
AB  - Two bradykinin potentiating peptides A-VI5 (Val-Glu-Ser-Ser-Lys) and BPP5a (Pyr
      Lys-Trp-Ala-Pro), were compared with respect to their potentiation of a number of
      different bradykinin effects on six isolated smooth muscle preparations. Apart
      from the considerable difference in effective concentrations, no essential
      qualitative difference was observed between these two peptides. Therefore the
      assumption of a different mechanism of action for the two peptides, which have a
      completely different structure, could not be substantiated.

PMID- 1033072
TI  - Selective 6OHDA-induced destruction of mesolimbic dopamine neurons: abolition of
      psychostimulant-induced locomotor activity in rats.
AB  - Selective large scale destruction of mesolimbic dopamine-containing terminals is
      produced by bilateral injection of 8 mug of 6-hydroxydopamine (6OHDA) into the
      nucleus accumbens septi (NAS) of rats pretreated with pargyline and desipramine
      (DMI). The DMI prevents the destruction of the noradrenergic innervation of the
      forebrain normally produced by the NAS 6OHDA lesion, without affecting the
      destruction of dopamine-containing neurons. The locomotor stimulation produced by
      the psychostimulants d-amphetamine (1.5 mg/kg) and cocaine (20 mg/kg) is blocked
      in rats with selective destruction of the mesolimbic dopamine system. In contrast
      the locomotor stimulation produced by the directly acting dopamine agonist
      apomorphine (1.0 mg/kg) is enhanced, which may indicate supersensitivity of the
      denervated dopamine receptors. These results lend further support to the view
      that psychostimulant-induced locomotr stimulation in rats results from effects on
      mesolimbic dopamine neurons. In addition, the protection by DMI of noradrenergic
      neurons from the toxic effects of 6OHDA is evidence that 6OHDA, as used here,
      destroys catecholamine neurons mainly by an uptake-dependent specific mechanism.

PMID- 1033073
TI  - p-Chloroamphetamine: short and long term effects upon shock-elicited aggression.
AB  - In a series of experiments the effects of p-chloroamphetamine (PCA) on shock
      elicited aggression in rats were investigated. 15 min after 5 mg/kg PCA, shock
      elicited aggression was inhibited. 2 h to 4 weeks after PCA, fighting was
      facilitated. Both the inhibitory and the excitatory effects of PCA were directly
      related to the dose of PCA (1.5, 2.5 OR 5 mg/kg) and were blocked by pretreatment
      with p-chlorophenylalanine but not by alpha-methyl-p-tyrosine. PCA-increased pain
      thresholds 15 min after injection and then decreased pain thresholds over the
      next 24 h but not thereafter, even though shock-elicited aggression continued to
      be facilitated. The results are consistent with the idea that inhibition of shock
      elicited aggression is associated with enhanced release of serotonin whereas
      enhancement of shock-elicited aggression is associated with serotonin depletion.

PMID- 1033074
TI  - Increased rate of disappearance of serum probenecid in barbital dependent rats.
AB  - Rats were made barbital dependent by administration of barbital in their drinking
      water. Subsequently, the rats were either not withdrawn (BN) or withdrawn from
      barbital for 24 h (BW-24). Before sacrifice, probenecid was administered to
      measure brain serotonin turnover. A statistically significant decrease in 5
      hydroxyindoleacetic acid (5-HIAA) accumulation was observed in the cerebral
      cortex medulla pons and  midbrain. Subsequentialy, serum levels of probenecid
      were also measured by gas chromatography to determine if chronic barbital
      consumption might affect circulating probenecid. By ninety minutes following
      probenecid administration, serum probenecid levels in BN and BW-24 rats were
      significantly lower than control while a probenecid metabolite was significantly
      increased. The significantly reduced accumulation of 5-HIAA in brain areas of BN
      and BW-24 rats is probably the result of the more rapid decline of probenecid
      rather than a true decrease in serotonin turnover.

PMID- 1033075
TI  - A stalk-specific localization of trehalase activity in Dictyostelium discoideum.

PMID- 1033076
TI  - Is melatonin a microtubule inhibitor?

PMID- 1033077
TI  - Configurational changes in rat liver nuclear chromatin and nucleoli caused by
      dissociation and reassociation of F1 histone.

PMID- 1033078
TI  - Amino acid uptake in Xenopus laevis oocytes.

PMID- 1033079
TI  - Cytoplasmic DNA-binding phosphoproteins of Physarum polycephalum.

PMID- 1033080
TI  - Experimental studies on the influence of male alcoholism on pregnancy and
      progeny.
AB  - Chronic alcoholism was induced in male albino rats by an oral self-administration
      technique. Obvious signs of intoxication, withdrawal symptoms and reduced
      reproductive performance, as well as decreased serum glucose and serum
      testosterone levels, were observed in these animals. Notable differences were
      detected in prenatal mortality, mean litter size and sex ratio between the
      offspring of male alcoholic rats and the corresponding controls. In the alcohol
      treated group the placental index was markedly reduced. However, the mean growth
      index showed no significant differences between the experimental and control
      groups.

PMID- 1033081
TI  - Ultrastructural investigation of peripheral arterial vessels in the cortex of
      rats with experimental hypertension.
AB  - The peripheral arterial blood vessels in the cerebrum of 36 experimental animals
      and 9 controls were studied by electron microscopy. In 5 rats of these renal
      hypertension was produced (the animals were sacrificed 3 to 15 days following the
      second operation). 24 animals were treated with depot angiotensin (0.02 to 2.5
      mg/daily) for 3 hr up to 40 days, and 7 rats were neurotized for 1 to 41/2
      months. The alterations of the cerebral vessels were distinctly different within
      these 3 models already in the early reactions. Thus, even in the first 14 days of
      the experiment with renal and angiotensinogenic hypertension alterations were
      observed that did never occur in the neurotized rats. There were always observed
      disturbances in permeability of the cerebral vessels, but they were never
      followed by such heavy wall insudations as usually noticed in the splanchnic
      vessels. The less frequent occurrence of hemorrhages and malacic processes in the
      rat brain is ascribed aside from the physiological properties of the brain
      supply, to genetic factors and the absence of arteriosclerotic burden to the
      vascular wall in the non-dietetically pretreated experimental animals.

PMID- 1033082
TI  - Endothelial lesions in the aorta of egg yolk-fed miniature swine: a study of
      scanning and transmission electron microscopy.

PMID- 1033083
TI  - Conformational dynamics of porcine pancreatic colipase: a 360MHz proton nuclear
      magnetic resonance study.

PMID- 1033084
TI  - Identification of the reactive sulphydryl group of mitochondrial aspartate
      aminotransferase from pig heart.

PMID- 1033085
TI  - Correlation of the base specificity of DNA--intercalating ligands with their
      physico-chemical properties.

PMID- 1033086
TI  - Porphyrin a as a precursor of heme a in Candida utilis.

PMID- 1033087
TI  - The role of delta subunit in the coupling activity of chloroplast coupling factor
      1.

PMID- 1033088
TI  - Thymidine kinase enzyme variants in Physarum polycephalum; change of pattern
      during the synchronous mitotic cycle.

PMID- 1033089
TI  - [Effect of electroshock convulsions on caudate nucleus function].
AB  - In unrestrained cats, after the electro--shock seizures, the afamphetamine-
      indused stereotype, behavior was increased and the caudate circular response to
      high--frequency stimulation was facilitated. The delayed response to low
      frequency stimulation of the caudate nucleus was, on the contrary, decreased.
      Thresholds of the circular and delayed responses to stimulation of the thalamus
      and capsula interna did not change in the post--seizure period. The above shifts
      are supposed to be due to weakening of the caudate nucleus inhibitory function
      resulting from the electro--shock--evoked increase in the caudate dophamine.

PMID- 1033090
TI  - Histomorphological changes in the female reproductive tract of Suncus murinus
      sindensis (Anderson) during the oestrous cycle.

PMID- 1033091
TI  - [Control of the ovary and measurement of electric resistance of vaginal secretion
      during the estrous cycle].

PMID- 1033092
TI  - [The effect of prostaglandin F 2 alpha on the activity of corpus luteum in cows].

PMID- 1033093
TI  - [Preliminary studies on the luteolytic factors in semen of stallions].

PMID- 1033094
TI  - A sequence of dependent stages in the development of Dictyostelium discoideum.

PMID- 1033095
TI  - Polarization of fucoid eggs by steady electrical fields.

PMID- 1033096
TI  - [Emphysematous colpitis in the late puerperium (author's transl)].
AB  - Two cases of emphysematous colpitis in the late post partum period are reported.
      The clinical symptoms and signs, the pathogenesis, the causes and the treatment
      of emphysematous colpitis in the puerperium are described.

PMID- 1033097
TI  - [A rare finding at gynaecological laparotomy: ovarian pregnancy and pinworm
      abscess (author's transl)].
AB  - A case of concommitant ovarian pregnancy and pinworm abscess is described. The
      histology and the incidence of Oxyuriasis in the female genital tract are
      discussed. The clinical symptoms and the management of the condition are also
      discussed.

PMID- 1033098
TI  - [Thrombotic thrombocytopenic purpura (Moschcowitz-syndrome) in pregnancy
      (author's transl)].
AB  - The case of a primigravida with thrombotic thrombocytopenic purpura (Moschcowitz
      Syndrome) is reported. The patient delivered a healthy male infant at 35 weeks
      gestation during a remission. The patient died at 10 days postpartum from a
      relapse of the disease. The special points in the differential diagnosis and
      treatment of thrombotic thrombocytopenic purpura during pregnancy are discussed.

PMID- 1033099
TI  - [Circumannual study of adrenal cortex function in species of migratory and non
      migratory sparrows].

PMID- 1033100
TI  - The qualitative and quantitative determinations of ecdysones in tissues of the
      crab, Pachygrapsus crassipes, following molt induction.

PMID- 1033101
TI  - [Comparative experimental data from a study of the state of the central nervous
      system using the conditioned method and the summation-threshold index method for
      setting hygienic standards].

PMID- 1033102
TI  - [Kininogenic system components present in rat endometrial secretions during
      estrus].

PMID- 1033103
TI  - Biorhythms and social work.

PMID- 1033104
TI  - [Respiratory function of mitochondria in the inner and outer layers of the dog
      myocardium].
AB  - The respiratory effect of dog myocardial mitochondria was studied by measuring
      oxygen content in a reaction chamber using Garbani electrode. 1) In normal dog
      mitochondria, oxygen consumption rate (QO2) in state 3 and state 4, respiratory
      control ratio (RCR) and ADP/O ratio were not different between the inner and
      outer layers when glutamate or succinate was used as substrate. 2) Thirty min
      after the occlusion of one of the small branches of the anterior descending
      artery, there were no differences in the respiratory effects between the inner
      and outer layers when glutamate or succinate was used as substrate. HOowever,
      compared with the normal dog mitochondria, ADP/O ratio, QO2 in state 3 and state
      4 were lower in the outer layer and QO2 in state 4 was lower in the inner layer
      when succinate was used as substrate. 3) When the anterior descending branch was
      narrowed to decrease the blood flow to about a half, the respiratory effects were
      not different between the inner and outer layers when succinate was used as
      substrate. However, ADP/O ratio in the outer layer was lower than that of the
      normal dog. 4) Nitroglycerin had no effect on the respiratory effects either in
      vitro (1.63 X 10(-6) M, succinate as substrate) or in vivo (20 mug/kg i.v.,
      glutamate as substrate.) 5) Dipyridamole had no effect on the respiratory effects
      in vivo (250 mug/kg, i.v., glutamate as substrate) but, ADP/O ratio in the outer
      layer was diminished in vitro (7.34 X 10(-6) M, succinate as substrate).

PMID- 1033105
TI  - [Pharmacological studies of antipsychotic drug, penfluridol. 2. General
      pharmacological properties].
AB  - General pharmacological properties of penfluridol (TLP-607) a long-acting
      antipsychotic drug, were examined in experimental animals and the following
      results were obtained. 1) TLP-607 produced a lowering of arterial blood pressure
      and bradycardia but had almost no effect on respiration and peripheral blood
      flow. 2) TLP-607 slightly hypertension induced by dopamine, adrenaline and
      noradrenaline, but had no effect on hypotension induced by acetylcholine and
      histamine. 3) Antagonistic actions of TLP-607 on such spasmogens as
      acetylcholine, histamine and barium chloride were slightly stronger than those of
      haloperidol and chlorpromazine. 4) TLP-607 had neither ganglionic nor
      neuromuscular blocking action. 5) TLP-607 had a slight or no effect in the
      following experiments; protection against stomach ulcer, activity of ileum and
      uterus in vivo and in vitro, urinary volume and electrolytes excretion, and
      gastro-intestinal propulsion. These results suggest that TLP-607 has no striking
      peripheral actions in experimental animals.

PMID- 1033106
TI  - [Analgesics and the kallikrein-kinin system].
AB  - The mechanism of analgesic actions of aspirin, aminopyrine and morphine was
      investigated in reference to the kallikrein-kinin system and the results
      suggested that the analgesic actions of these agents are definitely related with
      the peripheral kallikrein-kinin activity. The central action of kinin appears to
      differ from the peripheral action.

PMID- 1033107
TI  - [Pharmacological studies on bamboo grass. (2) Central depressant and antitoxic
      actions of a water-soluble fraction (folin) extracted from Sasa albomarginata
      Makino et Shibata].
AB  - Folin administered showed a significant antagonistic effect to caffeine induced
      hyperactivity and slightly prolonged hexobarbital induced sleeping time in mice.
      An antitussive effect was evident only with high doses and anticonvulsant effects
      were not observed. A mixture of Folin with HgCl2, NaAsO2, 3CdSO4-8H2O or
      tetrodotoxin resulted in an apparent decrease in mortality rates. However Folin
      had no effect in the case of alternate administration with a poison or
      preadministration of Folin. As other pharmacological properties of Folin, a
      protective effect on induced stress ulcer in rats and an increase in acid output
      in pylorus-ligated rats in which aspirin was administered. Folin had no
      inhibitory effect on reserpine ulcer and acetic acid induced anal ulcer in the
      rat. Neither an increase in gastric motility nor cathartic effect was observed
      with Folin. In addition, Folin showed a tendency of inhibition on heat induced
      edema and increase of urinary vikyne and electrolytes in rats.

PMID- 1033108
TI  - [Analgesic effects of Neurotropin in mice, and a comparison with analgesic effect
      of other drugs in SART-stressmice].
AB  - Analgesic effects of a neuroleptica "Neurotropin" (NSP) were studied in mice
      while the analgesic effects of other agents were studied in SART-stress mice
      (specific stress caused by alterating rhythm in temperature) and the results
      compared with those in normal mice. NSP is an extract containing many conjugated
      polysaccarides isolated from the skin or tissues of rabbits which had been
      inoculated with the living cowpox virus. (a) NSP given alone to normal mice
      resulted in slight analgesic effects as observed with the application of the
      acetic acid-, phenylquinon-writhing method or the modified Randall-Selitto
      method. Little effect was seen when the D'Amour-Smith was used. (b) Synergism was
      evident when NSP and aminopyrine or NSP and morphine were given concomitantly and
      the acetic acid- or phenylquinon-writhing methods were applied. (c) Analgesic
      effects of morphine, levomepromazine, imidazole acetic acid and particularly NSP
      were greater in SART-stress mice than in normal mice. With the D'Amour-Smith
      method, only NSP had a greater effect in SART-stress mice than in normal mice.

PMID- 1033109
TI  - [Behavioral pharmacology of a new antidepressant, lopramine].
AB  - The behavioral effects of lopramine [N-methyl-N-(4-chlorobenzoyl-methyl)-3-(10,
      11-dihydro-5H-dibenz (b,f) azepin-5-yl) propylamine hydrochloride] were
      investigated in mice and rats and compared with those of amitriptyline and
      imipramine. Lopramine inhibited reserpine hypothermia and haloperidol catalepsy
      in mice and tetrabenazine ptosis in rats. In addition the drug potentiated the
      effects of methamphetamine, and DOPA- or apomorphine-induced stereotypy in mice,
      whereas it suppressed muricide of the rat induced by either olfactory bulbectomy
      or delta9-tetrahydrocannabinol, similar to the responses seen with imipramine and
      amitriptyline. On the other hand,lopramine increased spontaneous motor activity
      and markedly potentiated methamphetamine hyperactivity. In contrast to imipramine
      and amitriptyline, lopramine failed to counteract both the lethal effect of
      physostigmine and oxotremorine tremor in mice, indicating that the drug had no
      central anticholinergic effect. Lopramine, even at such a large dose as 5,000
      mg/kg p.o., caused neitherimpairment of coordinated motor activity nor muscle
      relaxation. It is concluded that lopramine is a new type of tricyclic
      antidepressant with extremely low toxicity and without central anticholinergic
      action.

PMID- 1033110
TI  - [Inhibition of cholinesterase activity induced by pyridaphenthion].
AB  - Inhibitory effects on cholinesterase (ChE) activity in blood of the rabbit
      induced by pyridaphenthion(PD), an organophosphorus compound, and effects of 2
      pyridine aldoxime methiodide(PAM) on this inhibition were examined. 1)
      Experimental results within 24 hr: An oral administration of each dose of PD(100
      approximately 750 mg/kg) gradually decreased ChE activity and ChE activity value
      decreased to 20.5% in the erythrocytes and 21.5% in the plasma 24 hr after
      administration of 500 mg/kg of PD. However, this value recovered remarkably with
      an intravenous injection of PAM. The ChE activity value was 55.5% in the
      erythrocytes and 41.4% in the plasma with a single injection, and respectively
      67.8% and 59.1% when PAM was injected three times. 2) Experimental results for 14
      days: Following an increase of the administered dose (100 approximately 400
      mg/kg) of PD, a decrease in ChE activity was apparent and a recovery to normal
      values was delayed. This inhibition could be ameliorated quickly with an
      injection of PAM. Considering that PAM does not have remarkable detoxicative
      effects on organophosphorus compounds which have a low toxicity, PAM appears to
      be a promising antidote against PD.

PMID- 1033111
TI  - [Effects of lithium chloride on norepinephrine and dopamine metabolism in the rat
      brain].
AB  - Lithium chloride (LiCl) was injected acutely (2.4 mEq/kg and 1.2mEq/kg X 2 for 3
      hr, i.p.) or subacutely (2.5 mEq/kg X 2/day for 4.5 days, i.p.) in rats, and
      behavioral effects, steady state levels of norepinephrine (NE), dopamine (DA) and
      serotonin (5HT) and the metabolism of intraventricularly administered 14C-NE and
      14C-DA in the brain were investigated. Acute and subacute administratin of LiCl
      suppressed the spontaneous motor activity, but had no effect on the levels of NE,
      DA and 5HT in the brain. Acute administration of LiCl did not influence the total
      radioactivity and the levels of NE and its metabolites in NE metabolism, while
      subacute administration of LiCl increased the deaminated metabolites. In DA
      metabolism, the deaminated metabolites were decreased by acute administration of
      LiCl and the O-methylated deaminated metabolites were increased by subacute
      administration. From these results, it is suggested that LiCl stimulates the
      monoamine oxidase pathway in NE and DA metabolism and the behavioral sedative
      effects of LiCl are attributed to the reduced functional activity of brain NE and
      DA neurons.

PMID- 1033112
TI  - [Effects of MS4101, a new benzodiazepine compound, on evoked potentials induced
      by noxious stimulation of hind legs in cats].
AB  - The effects of 10-chloro-11b-(2'-fluorophenyl)-2,3,5,6,7,11b-hexahydro-7-(2''
      hydroxyethyl)benzo[6,7]-1,4-diazepino [5,4-b]oxazol-6-one (MS4101), a new
      benzodiazepine compound, on evoked potential in cats were examined and compared
      with diazepam. Though evoked potential in somatic cortex I, motor cortex I and
      posterior groups induced by tibial nerve stimulation were unaffected by a small
      dose of MS4101 (1 mg/kg) which did not influence on limbic system, the amplitude
      of evoked potential in midbrain reticular formation was reduced. The amplitude of
      evoked potential in amygdala and hippocampus induced by cutaneous nerve
      stimulation was reduced by MS4101 and diazepam. These two drugs had the same
      effect on amygdala and difference in the degree of action between these drugs was
      not observed. Sham rage response following head shake, circling and whine
      behaviour was observed by electrical stimulation of the hypothalamus. The
      threshold of sham rage response by raised by MS4101 and diazepam.

PMID- 1033113
TI  - [Pharmacological actions of a new antihypertensive drug, olmidine, on the
      gastrointestinal tract].
AB  - It has been reported that dl-2-(3,4-methylenedioxyphenyl)-2-hydroxyacetamide
      hydrochloride (Olmidine) shows an antihypertensive action through inhibition of
      the adrenergic transmission. The present experiment was an attempt to investigate
      the pharmacological actions of olmidine in the alimentary canal of rat, rabbit
      and guinea pig. We found that the salivary secretion of rabbit was unaffected by
      olmidine at a dose of 2 mg/kg i.v., but increased by approximately 3 times that
      of controls with 10 mg/kg i.v.. Volume of gastric juice, concentration of free
      HCl, total acidity and pH of gastric juice in Shay rats were unaffected by 20
      mg/kg i.p. of olmidine while volume and free HCl were significantly reduced at a
      dose of 100 mg/kg i.p. of the drug. The pH of gastric juice showed an evident
      increase to 3.33. Total acidity, however, was unaffected. Bile secretion of rat
      was decreased by olmidine at a dose of 100 or 500 mg/kg i.p. in a dose-dependent
      manner. Olmidine did not induce any lesion of gastric mucosa of rats at a dose of
      200 mg/kg p.o. or less. Movement of charcoal meal in the small intestine of rats
      was inhibited by olmidine at doses of 20 to 500 mg/kg p.o.. Olmidine caused a
      biphasic response, that is contraction followed by a relaxation,in the isolated
      guinea pig gastrointestinal tracts. The contractile response caused by olmidine
      was completely inhibited by pretreatment with atropine or scopolamine and
      converted to one of relaxation which was unaffected by a combined treatment with
      phentolamine and propranolol. Contractile responses caused by transmural
      stimulation were significantly potentiated by olmidine, while potentiation of the
      contractile responses caused by exogenously applied acetylcholine was only slight
      in the isolated gallbladder from guinea pig.

PMID- 1033114
TI  - [Effects of eserine and ouabain on the febrile reaction induced by
      lipopolysaccharide].
AB  - We investigated the effects of eserine and ouabain on the permeability of the
      blood-brain barrier (B.B.B.) as related to the febrile response induced with LPS
      in rabbit. Results are as follows; The febrile response induced by LPS (0.02 and
      1.0 mug/kg) i.v. was suppressed by administration of ouabain (0.06 mg/kg, i.v.).
      Contrary to the febrile response of LPS given i.c. (10(-4) and 10(-3) mug/kg),
      the febrile response was not suppressed with the same dose of ouabain. The
      pyrogenicity of cerebrospinal fluid (CSF) withdrawn at two hours after rabbits
      had been injected with LPS (25 mug/kg) was suppressed by ouabain (0.06 mg/kg,
      i.v.). Pyrogenic response was enhanced by pretreatment with eserine (0.5 mg/kg,
      s.c.) given one hr before LPS (1 mug/kg, i.v.). The pyrogenicity of CSF was also
      potentiated to a greater extent by pretreatment of eserine than with LPS alone.
      In the eserinized rabbit (0.5 mg/kg, s.c.), the pyrogenicity of CSF was
      potentiated to a greater extent by ACh (10 mug/kg, i.v.) than by LPS (1 mug/kg,
      i.v.) alone. From these data, it is concluded that the inhibition of Na, K-ATPase
      by ouabain decreases the pyrogenicity of LPS, while the inhibition of
      cholinesterase by eserine enhances the pyrogenicity.

PMID- 1033115
TI  - Effect of crotonaldehyde on the metabolism of Candida utilis during the
      production of single cell protein from ethanol.
AB  - The effect of 20 low-boiling compounds on the yeast Candida utilis 49 was
      assessed by a screening test on agar medium. The highest toxicity was exhibited
      by crotonaldehyde, allyl alcohol and acrolein. Oxidation and assimilation
      experiments in a slightly aerobic environment showed that an increase in the
      level of crotonaldehyde in the medium in the range of 10--20 mg 1-1 brings about
      a lowering of intensity of metabolic processes in Candida utilis, suppression of
      ethanol utilization and aerobic oxidation rate, a drop in biomass yield,
      prolongation of cultivation time, etc. The inhibitory effect of crotonaldehyde
      depends strongly on the manner of its dosage into the medium (single or
      continuous) and other cultivation conditions (intensity of medium aeration,
      physiological state of the culture, etc). Crotonaldehyde is lost from the medium
      partially by volatilization and partially due to chemical and biochemical
      transformation.

PMID- 1033116
TI  - Predactious fungi Dactylaria pyriformis and Dactylaria thaumasia: production of
      attractants and nematicides.
AB  - Dactylaria pyriformis Juniper and Dactylaria thaumasia Drechsler are predacious
      fung forming three-edimensional sticky reticula in which nematodes are captured.
      It was shown by methods developed in our laboratory that in submerged
      cultivations both of these fungi produce substances attracting nematodes and
      compounds having nematicidal activity.

PMID- 1033117
TI  - [Germinal testicular tumors].
AB  - Characteristic for the germinal cell tumors of the testis is their great variety.
      Collins and Pugh gave a classification of testis tumors under consideration of
      the genesis of the tumor and the clinical progressing. The staging should be done
      according to the TNM-system which is based on the UICC recommendations of 1973.
      If a tumor is suspected an exploration of the testis must be performed. After
      definitive histological diagnosis via immediate section for microscopic
      examination during surgery an enlarged orchiectomy and local lymph node
      dissection has to be performed. In cases of seminoma a 5-year-survival-rate of 90
      to 97 per cent can be achieved by radiation of two fields (4 fields in case
      metastases are suspected). Because of the radio resistance of the teratoid tumors
      a retroperitoneal lymph node dissection has to follow the enlarged orchiectomy.
      With a subtile operating technique all the lymph nodes between diaphragm and
      aortic bifuraction can be removed in case of operability. Postoperative radiation
      therapy is only recommended in case of excessive lymph node metastases. By an
      adjuvant chemotherapy following retroperitoneal lymph node dissection a 5-year
      survival-rate of more than 80 per cent can be obtained in cases of teratoid
      tumors.

PMID- 1033118
TI  - [Morpholgical changes in the rabbit's bladder after argon laser irradiation].
AB  - After developing a flexible fiber light guide and a special cystoscope it was
      possible to study the Argon laser beam effects on the bladder wall of rabbits and
      dogs. It could be proved that the Argon laser is qualified for the use in organs
      with thin walls, especially in the urinary bladder, because of its strong
      absorption in tissue with high blood flow and its minor penetretion depth.
      However, our further investigations showed--they shall be published--that the
      output of the Argon laser used in our studies not sufficient for destroying human
      bladder tumors. For this reason it is necessary to use neodymium YAG laser.

PMID- 1033119
TI  - [Acute and chronic diseases of the prostate. Etiology, diagnosis, therapy].

PMID- 1033120
TI  - [Systemic mycoses. 3. Systemic mycoses due to saccharomycetes (cryptococcosis
      candidiasis, torulopsidosis)].

PMID- 1033121
TI  - [Study on the nephrotoxicity of antirheumatic drugs. III. Influence of various
      cytostatics on urinary enzymes].

PMID- 1033122
TI  - [Clinico-morphological confrontation in synovitides of the knee joint.
      (Contribution to the problem of significance of articular needle biopsy].

PMID- 1033123
TI  - [New nonsteroid antirheumatic drugs presented at the VIIIth European
      Rheumatological Congress in Helsinki].

PMID- 1033124
TI  - [Disorders of skeleton mineralization in progressive polyarthritis. I. Influence
      of corticoids].

PMID- 1033125
TI  - [Problem of adaptation changes of erythrocytes and sea-level altitude].

PMID- 1033126
TI  - [Effects of various uses of hydrotherapy in the complex electrodermographic
      evaluation].

PMID- 1033127
TI  - [Effect of mineral water on the secretion of insulin in an acute experiment].

PMID- 1033128
TI  - [Use of diadynamic currents in the treatment of vasomotor cephalalgia within the
      scope of complex valveotherapy].

PMID- 1033129
TI  - [Electroneurography. Comparative study of orthodromic and antidromic
      neurography].

PMID- 1033130
TI  - [Familial aggregation and an attempt at the evaluation of heredity in Bechterew's
      disease].

PMID- 1033131
TI  - [Prostaglandins and their significance in rheumatology. Comprehensive review].

PMID- 1033132
TI  - [Climatotherapy in health resorts].

PMID- 1033133
TI  - [Biotelemetry in health-resort rehabilitation. II. Follow-up of movement activity
      in nature].

PMID- 1033134
TI  - [Synthesis and biological activity of the decapeptide Gly-Pro-Cys-Lys-Ala-Arg-Phe
      Gly-Gly-Cys as a model for the active center of the basic trypsin inhibitor from
      bovine organs (Kunitz inhibitor) (author's transl)].
AB  - The synthesis of the above mentioned decapeptide as a model for the active center
      of the inhibitor molecule is described. The Ki value of this peptide was found to
      be 4.7 X 10(-4)M. This Ki value differs from the Ki value of the Kunitz Inhibitor
      by a factor of 10(10).

PMID- 1033135
TI  - Effect of d-galactosamine administration on nucleotide and protein metabolism in
      isolated rat Kupffer cells.
AB  - The nucleoti-e contents of isolated rat Kupffer cells were found to be smaller
      than those of hepatocytes. The rate of UDPGal formation from D-galactose was much
      lower in Kupffer cells than in hepatocytes. The viability of the former was
      checked by measuring the leakage of enzymes and the formation of UTP from
      uridine. Addition of GalN to isolated Kupffer cells did not decrease their UTP
      and UDPG contents as much as those of hepatocytes. The same results were obtained
      when cells were isolated from GalN-pretreated animals. The incorporation of
      labeled amino acids into protein after GalN addition was much less reduced in
      Kupffer cells than in hepatocytes. The data suggest that Kupffer cells do not
      contribute to GalN-induced liver injury as a result of uridylate trapping.

PMID- 1033136
TI  - [Glycine hydrazide as a bifunctional reagent for the synthesis of antigens with
      steroids as the immunodeterminant groups (author's transl)].
AB  - The suitability of glycine hydrazide as a link between steroids and carrier
      proteins in the synthesis of antigens was examined. Testosterone was used as
      hapten; bovine serum albumin as carrier protein. The reaction described here of
      testosterone with glycine hydrazide to form testosterone glycylhydrazone acetate
      took place under milk conditions and the yield was nearly quantitative. Rabbits
      immunized with the new antigen developed specific antibodies against
      testosterone.

PMID- 1033137
TI  - Biosynthetic incorporation of fatty acids with photosensitive groups into
      membrane lipids of cells in tissue culture.
AB  - The physical methods (13C-NMR-spectroscopy and fluorescence spectroscopy)
      hitherto used for the elucidation of lipid-lipid and lipid-protein interactions
      in artificial and simple natural membranes were extended to the application of
      fatty acids, phospholipids and sphingolipids with photochemical labels (azide
      group) in defined positions, which on photolysis generate nitrenes. These highly
      reactive groups react with neighbouring molecules, either lipids or polypeptide
      chains, with insertion or addition. Highly radioactive 12-azido[9,10-3H2]stearic
      acid, 12-azido[12-3H]oleic acid and 18-azido-[9,10,12,13-3H4]linoleic acid were
      added to the growth medium of eukaryotic cell lines in tissue culture (BHK 21
      cells and Chang liver cells). They were incorporated into neutral, phosphoand
      sphingolipids in amounts comparable with the unsubstituted parent fatty acids.
      The distribution of the azido fatty acids in the phospholipids has been
      determined by enzymatic hydrolysis (phospholipase A2) on the basis of the
      distribution of their radioactivity. Radio gas chromatography and combined gas
      chromatography and mass spectroscopy revealed that the azide group of the
      radioactive fatty acids remained unaltered.

PMID- 1033138
TI  - Biosynthetic labelling of membrane lipids of eukaryotic cells in tissue culture
      by a novel type of fluorescent fatty acids.
AB  - W-Anthryl labelled fatty acids with hydrocarbon chains of different lengths (C8,
      C11, C15) and different degrees of unsaturation have been incorporated into the
      membrane lipids of three different cell lines in tissue culture by addition of
      these 3H-labelled precursor fatty acids to the growth medium. The cell lines were
      baby hamster kidney cells (BHK 21), Chang liver cells and the RN6 cell line
      derived from a chemically induced Schwannoma tumor cell clone. Cell growth was
      normal. The quantitative analysis on the basis of radioactivity determinations
      demonstrated that the fluorescent-labelled fatty acids were introduced into the
      neutral lipid fraction (triglycerides, diglycerides, and cholesterol esters, all
      present in small amounts), but mainly into the phospholipid classes
      phosphatidylcholine, -ethanolamine and -serine, and to a lesser extent, as N-acyl
      component of sphingolipids (sphingomyelins, ceramides, mono- and
      diglycosylceramides). Cell fractionation studies indicated that the membranes of
      all subcellular particles were labelled with the fluorescent probes in their
      lipid moieties. These w-anthryl fatty acids are the first type of fluorescent
      lipid precursors which can be incorporated biosynthetically in vivo into membrane
      lipids of eukaryotic cells. The effective incorporation of the bulky fluorescent
      anthryl group in the terminal position of fatty acids of different chain lengths
      into the complex membrane lipids of the cell gives proff of 1) their uninhibited
      membrane transport, 2) their activation by the acyl-CoA synthetase and 3) their
      substrate properties for the O- acyl and N-acyl transferases in phospho- and
      sphingolipid biosynthesis.

PMID- 1033139
TI  - Influence of insulin on lysosomal activity and urea production in isolated
      parenchymal cells from rat liver.
AB  - Non-latent (free) activities of two lysosomal enzymes (acid phosphatase and beta
      glucuronidase) and urea production were measured in purified rat liver
      parenchymal cells incubated in the presence and absence of insulin. Non-latent
      enzyme activity was measured by including 0.25M sucrose in the assay mixtures to
      provide osmotic protection to the lysosomes. Total enzyme activity was estimated
      with Triton X-100 in the homogenates. Insulin was found to inhibit ureogenesis
      and to reduce non-latent lysosomal enzyme activity in the hepatocytes in vitro.
      Our data support the idea that insulin inhibits autophagy in rat liver
      parenchymal cells. Such an effect of insulin may also explain the inhibitory
      action of insulin on urea production in the rat liver.

PMID- 1033140
TI  - A survey of patients leaving a mental hospital against medical advice.
AB  - A consecutive series of 100 male psychiatric patients who requested release
      against medical advice during an 11-month period was compared with a control
      group consisting of a random sample of 100 patients admitted during the same
      period who did not submit such a request. The majority of those who submitted the
      request were alcoholics or schizophrenics. The authors found that a sizable
      number were either separated or divorced, were younger than patients in the
      control group, and were in more turbulent phases of their illness. A surprising
      finding was that 60 patients submitted the request while on an open ward.

PMID- 1033141
TI  - Feedback: Norris, Larsen paper stimulates reports of similar efforts to identify
      service priorities.

PMID- 1033142
TI  - Reimbursement policies effective January 1, 1977.

PMID- 1033143
TI  - Comparison of skeletal muscle monolayer cultures initiated with cells dissociated
      by the vortex and trypsin methods.
AB  - Monolayer cultures of 12-day embryonic chick skeletal muscle were prepared from
      cells dissociated with crude trypsin (Difco 1:250) and by a mechanical method
      that utilizes shearing forces obtained in a vortex of flowing medium. For each
      technique, experiments were performed in which the feeding schedule and density
      of cells planted were varied. Culture growoth was observed microscopically and
      with time-lapse cinematography. Regardless of the parameter varied, the time of
      onset of fusion and the extent of myotube formation were greatly improved in
      cultures initiated with the vortex-dissociated muscle cells.

PMID- 1033144
TI  - Enzyme separation techniques for the study of growth of cells from layers of
      bovine dental pulp.
AB  - Effects of the enzymes trypsin, papain, bromelains and ficin on bovine dental
      pulp tissue were studied. Minced or whole pulps were subjected to each enzyme at
      17 degrees, 20 degrees and 37 degrees C for set time intervals, after which
      aliquots of supernatant fluid were removed for cell counts and viability tests.
      Pooled samples were subsequently cultured as monolayers in Eagle's MEM plus 10%
      calf serum. The dissociation characteristics were quite distinct for each enzyme,
      although quite similar between minced and whole pulp. A parallel histological
      study was made of the residual pulp tissue. Ficin was found to be the most
      suitable enzyme for future studies on the growth of isolated pulp cells from
      various layers of the bovine pulp, due to its even rate of cell removal, and the
      good initial viability and subsequent growth of the separated cells in monolayer
      culture. Further studies on ficin may show that it is more suitable for enzymatic
      separation of tissues generally than the more commonly used trypsin, a major
      advantage being its use in media containing Ca2+ and Mg2+.

PMID- 1033145
TI  - Rainbow trout leukocyte culture: a simplified method.
AB  - The addition of 10% fetal bovine serum to Leibovitz's L-15 culture medium
      resulted in marked growth of peripheral blood leukocytes from rainbow trout,
      Salmo gairdneri. Culture medium without serum or with 20% homologous serum did
      not induce substantial growth. In contrast to what has been reported by others,
      oxygenation of the culture medium was found not to be required for excellent cell
      growth.

PMID- 1033146
TI  - Effect of atromid-S (clofibrate) on egg-yolk induced atherosclerosis in rabits.

PMID- 1033147
TI  - Relative combining affinities of anti-p-azophenylarsonate antibodies bearing a
      cross-reactive idiotype.

PMID- 1033148
TI  - Development of immunoglobulin and antibody-synthesizing cells after immunization
      with different doses of antigen.
AB  - The kinetics of development of antibody-synthesizing cells and of cells
      synthesizing immunoglobulins without detectable antibody function were studied in
      rats immunized with different doses (0-1, 1, 10, 100 mg) of horse radish
      peroxidase, bovine serum albumin, human serum albumin, hen ovalbumin, or human
      IgG, which had been deaggregated or heat-aggregated. Each antigen was injected
      once or twice as a solution in saline. Antibody and immunoglobulin-producing
      cells were detected in draining lymph nodes by immunohistochemical staining. In
      the primary response a few antibody-synthesizing cells were found whatever the
      dose injected. No increase or some increase was found with the amount of antigen
      injected, according to the protein used, but with all doses of antigen injected,
      the population of cells remained small, except with human IgG where a relatively
      high number of positive cells was detected even after injection of 1 mg of
      antigen. In the secondary response a few antibody-forming cells were also
      detected with the lower doses of antigen, but this population increased after
      boosting with 100 mg of antigen. With human IgG a greater number of positive
      cells was induced withall the doses tested. A correlation between the number of
      cells synthesizing immunoglobulins without antibody function and the amount of
      antigen injected was observed in the primary and secondary responses. The
      relative size of these two populations varied with the stage of immunity of the
      animals. In the primary response, the population of cells synthesizing
      immunoglobulins without antibody function was larger than the population of
      antibody-forming cells. The same was true in the secondary response, but if after
      a booster injection the level of antibody-synthesizing cells exceeded that
      reached in the primary response, the increase of cells synthesizing Ig without
      antibody function was smaller than the increase in antibody-forming cells. In
      general the more immunogenic an antigen was, the smaller was the ratio between
      antibody-forming cells and cells producing immunoglobulin without antibody
      function.

PMID- 1033149
TI  - Role of acetaldehyde in acetoin synthesis in yeasts & bacteria.

PMID- 1033150
TI  - Anthelmintic activity of berberine hydrochloride against Syphacia obvelata in
      mice.

PMID- 1033151
TI  - Electrical activity of the nervous system of the aestivating snail Pila globosa
      (Swainson): part II-modification of electrical activity by body fluids and amino
      acids.

PMID- 1033152
TI  - Utilization of heptachlor by fungi.

PMID- 1033153
TI  - Haemagglutinating property of buffalo-pox virus.

PMID- 1033154
TI  - Comparative evaluation of Fecalyzer diagnostic system with other methods for
      detection of ova in stool specimens.

PMID- 1033155
TI  - Sertoli-cell adenoma in a case of testicular feminisation--a case report.

PMID- 1033156
TI  - Isolation of a factor causing morphological changes of chinese hamster ovary
      cells from the culture filtrate of Vibrio parahaemolyticus.
AB  - A factor changing Chinese hamster ovary cells from an oval to a spindle shape was
      isolated from the culture filtrate of Vibrio parahaemolyticus. It was partially
      purified by successive column chromatographies on diethylaminoethylcellulose,
      diethylaminoethyl-Sephadex A-25, hydroxylapatite, and Sephadex G-200. This factor
      was separated from thermostabl direct hemolysin and was heat labile.

PMID- 1033157
TI  - Reliability of self-reported age of first drug use: analysis of New York City
      narcotics register data.
AB  - New York City Narcotics Register data were analyzed to determine the consistency
      of self-reported age of first drug use among multiple reports on a single
      individual. There were 15,263 individuals with two or more reports between
      January 1973 and April 1974 which specified age of first drug use. Discrepancies
      were noted in 68% of cases; in 31% the responses differed by 3 or more years.
      Even among reports from a single agency, there were discrepancies in 45% of
      cases. The degree of consistency was only slightly better when the analysis was
      restricted to subjects 20 years of age and younger. No comparable inconsistency
      was observed with respect to self-reported year of birth.

PMID- 1033158
TI  - Procedure for outpatient argon laser iridectomies for angle-closure glaucoma.

PMID- 1033159
TI  - Diabetic macular edema.
AB  - Photocoagulation by either the argon laser or xenon arc instruments has been
      reported to have a beneficial effect in selected patients with macular edema.
      Treatment is not effective in all cases; indeed, in some patients with perifoveal
      capillary closure, severe macular edema, long-standing organized hard exudates,
      or significant cystoid maculopathy, treatment has proved to be ineffective.
      Findings associated with a generally favorable or an unfavorable prognosis
      following photocoagulation are discussed in this chapter, along with proper
      management of the patient's systemic status, with particular emphasis on the
      problem of hypertension, important in patients with diabetic macular edema.
      Because the results of photocoagulation are limited in a significant number of
      patients, further research into the basic pathogenetic mechanisms involved in
      increased retinal capillary permeability to recommended, with the hope of
      providing more effective therapy.

PMID- 1033160
TI  - Argon laser photocoagulation in retinal branch vein occlusions.

PMID- 1033161
TI  - Focal photocoagulation of retinovitreal neovascularization.

PMID- 1033162
TI  - Complications of argon laser retinal photocoagulation: a five-year study.
AB  - The operator must become familiar with the dangers involved with argon laser
      photocoagulation. The hazards in the use of the argon laser slit-lamp
      photocoagulator derive from the same properties of the instrument that make it
      advantageous for the treatment of retinal vascular diseases: the wavelengths are
      highly absorbed by blood, and the beam can be focused to a small diameter. Of
      course complications can be avoided entirely by using applications so light the
      virtually no effect is obtained; but such an approach, although safe, cannot be
      therapeutic.

PMID- 1033163
TI  - Ruby laser photocoagulation of proliferating diabetic retinopathy: fifth-year
      followup.

PMID- 1033164
TI  - Argon laser photocoagulation in ocular histoplasmosis syndrome.
AB  - Argon laser photocoagulation was performed on 30 patients with ocular
      histoplasmosis syndrome involving the macula. Selection of patients for
      photocoagulation was dependent upon locating the sub-retinal neovascularization
      (SRNV) at least one vein-width removed from the capillary-free zone of the fovea
      on fluorescein angiography. Of the 30 treated patients, 27 maintained or improved
      visual acuity an average of 1 1/2 years following photocoagulation.

PMID- 1033165
TI  - Photocoagulation in diabetic retinopathy.

PMID- 1033166
TI  - Argon Laser Photocoagulation of proliferative diabetic retinopathy.

PMID- 1033167
TI  - Electrical parameters of the isolated cornea of the dogfish, Squalus acanthias.
AB  - The electrical potential difference and electrical resistance of the nonswelling
      cornea of the dogfish, Squalus acanthias, were examined. It was found that
      routine procedures used in the procurement of fish invariably produce damage to
      the corneal epithelium which affects electrical measurements and possibly
      composition of the aqueous humor. We found no electrical evidence of ionic pumps
      in the corneal epithelium of this elasmobranch. The electrical resistance of
      corneas with apparently well-preserved epithelium was 300omega-cm.2 (compared to
      30omega-cm.2 in corneas with damaged epithelium).

PMID- 1033168
TI  - Retinol- and retinoic acid-binding proteins: occurrence in human retina and
      absence from human cultured fibroblasts.
AB  - Low-molecular-weight retinol- and retinoic acid-binding proteins were shown to be
      present in the soluble fraction of human retinal tissue but absent from human
      fibroblasts grown in tissue culture. By the use of gel filtration and comparison
      with bovine retinal tissue, the human intracellular binding proteins were found
      to have molecular weights of approximately 17,000 daltons, which are comparable
      to the molecular weights of bovine intracellular binding proteins. The quantity
      of retinoic acid bound exceeded that of retinol by about eightfold.

PMID- 1033169
TI  - Normal interaction of plasma retinol-binding protein from retinitis pigmentosa
      with bovine pigment epithelium.
AB  - The interaction between retinol-binding protein and normal bovine pigment
      epithelium has been studied with the use of iodinated retinol-binding protein
      isolated from the plasma of patients with the recessive form of retinitis
      pigmentosa and of normal subjects. It is concluded that the capacity of the
      plasma carrier protein to interact with the retinol-binding protein receptor of
      bovine pigment epithelium is unimpaired in retinitis pigmentosa with autosomal
      recessive inheritance.

PMID- 1033170
TI  - Implications of family studies for the treatment of schizophrenia.

PMID- 1033171
TI  - Parents, children, and the moral benefits of research.

PMID- 1033172
TI  - A theoretical study of concentration of profiles of primary cytochemical-enzyme
      reaction products in membrane-bound cell organelles and its application to
      lysosomal acid phosphatase.
AB  - A numerical method was developed for computing the steady-state concentration
      gradient of a diffusible enzyme reaction product in a membrane-limited
      compartment of a simplified theoretical cell model. In cytochemical enzyme
      reactions proceeding according to the metal-capture principle, the local
      concentration of the primary reaction product is an important factor in the onset
      of the precipitation process and in the distribution of the final reaction
      product. The following variables were incorporated into the model: enzyme
      activity, substrate concentration, Km, diffusion coefficient of substrate and
      product, particle radius and cell radius. The method was applied to lysosomal
      acid phosphatase. Numerical values for the variables were estimated from
      experimental data in the literature. The results show that the calculated
      phosphate concentrations inside lysosomes are several orders of magnitude lower
      than the critical concentrations for efficient phosphate capture found in a
      previous experimental model study. Reasons for this apparent discrepancy are
      discussed.

PMID- 1033173
TI  - [Selective scintillography of the salivary glands (author's transl)].
AB  - The salivary glands of 32 patients were studied with scintillography. Ten
      patients were normal controls, while the remaining 22 patients had various
      disease processes involving their salivary glands. Scintillography was performed
      by two methods: the standard technique utilizing intravenous isotope injection
      and selective scintillography. According to this latter method, the radioisotope
      used is administered only to the gland under investigation by selective
      catheterization. The present study includes the results of this work, the
      advantages and disadvantages of each technique employed, and the indications for
      further use of selective scintillography.

PMID- 1033174
TI  - Sensitivity distribution of phytopathogenic bacteria and fungi to antibiotics.
AB  - The minimal inhibitory concentrations (MIC) of various antibiotics and fungicides
      for Erwinia carotovora, Pseudomonas coronafaciens var. atropurpurea, P.
      lachrymans, Alternaria mali, A. kikuchiana, Pyricularia oryzae, Botrytis sp. and
      Sclerotinia sp. isolated from diseased plants in various localities of Japan were
      examined to enable the isolates to be gruoped into sensitive and resistant
      strains. To minimize the effects of various variable conditions, MIC of isolates
      were pooled for either 2 or 3 years and were plotted in a single figure. The
      grouping values were determined on the basis of MIC values of the antibiotics and
      agricultural chemicals on phytopathogenic bacteria and fungi under
      investigations. The relationships between grouping values for isolates of
      bacteria and fungi and the control of disease on the plants correlated to each
      other were studied.

PMID- 1033175
TI  - 125I-Radioimmunoassay of amikacin and comparison with a microbioassay.
AB  - A radioimmunoassay (RIA) has been developed using 125I-amikacin. Amikacin was
      iodinated by a modified BOLTON and HUNTER method. Dextran-charcoal was used to
      separate bound from free drug. The standard curve was linear on a logit-log plot
      in the range of 0.5 ng to 4 ng amikacin per tube. There was no cross-reactivity
      of amikacin antisera to the amino-glycosides gentamicin, tobramycin, netilmicin,
      and sisomicin but a 70% cross-reaction was observed with kanamycin, the compound
      from which amikacin is synthetically derived. Correlation of the RIA with a
      microbioassay for the determination of serum amikacin levels in 18 patient
      samples was excellent (r = 0.94). This new RIA technique is more sensitive,
      rapid, versatile, and less costly than the RIA using 3H-amikacin, and is far more
      sensitive and faster than microbioassay.

PMID- 1033176
TI  - Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase.
AB  - In the screening of catechol-O-methyltransferase inhibitors, three compounds were
      isolated from the culture filtrate of a mushroom, Inonotus sp. One was 3,4
      dihydroxycinnamic acid (caffeic acid) which had been reported as an inhibitor of
      this enzyme. The others were the dextrorotatory 2,6-bis-(3',4'-dihydroxyphenyl)
      3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione (dehydrodicaffeic acid dilactone)
      andits antipode. These new compounds inhibited both dopamine beta-hydroxylase and
      dopa decarboxylase and showed hypotensive activity in the SH rat.

PMID- 1033177
TI  - High performance liquid chromatography of natural products. I. Separation of
      cephalosporin C derivatives and cephalosporin antibiotics;isolation of
      cephalosporin C from fermentation broth.
AB  - Microbonded propylamine silica with a solvent system containing acetic acid,
      methanol, acetonitrile and water (2:4:7.5:86.5) is suitable for an efficient
      separation of mixtures containing several closely related cephem derivatives. The
      same system with preparative columns was used for the isolation of cephalosporin
      C directly from the filtered broth of C. acremonium fermentation.

PMID- 1033178
TI  - L-aspartate of erythromycin A cyclic 11,12-carbonate, a new semisynthetic
      erythromycin derivative.
AB  - Erythromycin A cyclic 11,12-carbonate, a compound with high antibacterial
      activity, forms with L-aspartic acid a salt possessing valuable properties as a
      potential chemotherapeutic agent. The L-aspartate of erythromycin A cyclic 11,12
      carbonate exhibits strong anti-bacterial activity, especially against Gram
      positive bacteria and shows low toxicity. The serum and the lung tissue levels of
      the discussed salt after a single dose administration to a rat were measured in
      comparison with those of erythromycin, its L-aspartate, erythromycin cyclic 11,12
      carbonate and its L-glutamate. The new erythromycin derivative showed definitely
      superior characteristics to those of the other substances tested. The activity of
      the L-aspartate of erythromycin A cyclic 11,12-carbonate in chemotherapy of
      experimental staphylococcal infection and experimental pneumococcal
      bronchopneumonia in mice is superior to that of the parent carbonate and
      erythromycin itself.

PMID- 1033179
TI  - Effects of protease inhibitors of actinomycetes on the first component of human
      complement.

PMID- 1033180
TI  - A simplified method for the gas-liquid chromatographic determination of methyl
      mercury in fish and shellfish.
AB  - A simple acetone wash of the fish sample which removes lipids and other organic
      materials replaces the cystein cleanup specified in other methods. Methyl mercury
      is freed by hydrochloric acid, extracted into benzene, and determined with a gas
      liquid chromatograph equipped with an electron capture detector. The method is
      quantitative for methyl mercury levels as low as 0.10 ppm in fish and shellfish.
      Ethyl mercury chloride may be used as an internal standard to detect unsuspected
      error or instrumental parameter variation.

PMID- 1033181
TI  - A study of renaturation of reduced hen egg white lysozyme. Enzymically active
      intermediates formed during oxidation of the reduced protein.
AB  - The material obtained from reduced hen egg white lysozyme after complete air
      oxidation at pH 8.0 and 37 degrees has yielded, by gel filtration on a Bio-Gel P
      30 column, enzymically active species and an enzymically inactive form which
      eluted sooner than the active species but later than expected for a dimer of
      lysozyme. Reduced lysozyme also elutes at the same position as this inactive
      material. Examination of the fragments produced on CNBr cleavage of the inactive
      form indicates that at least 24% of the population contains incorrect disulfide
      bonds involving half-cystine residues 6, 30, 115, and 127. Tryptophan
      fluorescence and the intrinsic viscosity of the inactive form show an enlarged
      molecular domain with a disordered conformation. The yield of the inactive form
      increases as the oxidation of reduced lysozyme is accelerated using cupric ion.
      In the presence of 4 X 10(-5) M cupric ion, reduced lysozyme forms almost
      quantitatively the inactive form, which is almost completely converted to the
      native form by sulfhydryl-disulfide interchange catalyzed by thiol groups of
      either reduced lysozyme or beta-mercaptoethanol. The material trapped by
      alkylation of the free sulfhydryl groups with [1-14C]iodoacetic acid during the
      early stage of air oxidation of reduced lysozyme was fractionated by gel
      filtration to permit separation of the active species from the inactive form. Ion
      exchange chromatography of the active species yielded completely renatured
      lysozyme and three major enzymically active radioactive derivatives. Two of these
      derivatives contained approximately 2 mol of S-carboxymethylcysteine. Isolation
      and characterization of radioactive tryptic peptides from each of the three
      active forms, permitted the identification of Cys 6 and Cys 127, Cys 76 and 94,
      and Cys 80 as the sulfhydryl groups alkylated in these three incompletely
      oxidized, partially active forms. Thus, it appears that the interatomic
      interactions maintaining the compact three-dimensional structure of native
      lysozyme are operational even when one of these three native disulfide bonds
      between Cys 6 and Cys 127, Cys 76 and Cys 94, and Cys 64 and 80 is open.

PMID- 1033182
TI  - Ultrasonographic evaulation of breast masses.
AB  - B-mode ultrasonic contact scanning should be performed in conjunction with
      mammography in any patient with a palpable breast mass that is 1 cm or larger in
      diameter. Patients with masses that appear cystic on the sonogram should undergo
      needle aspiration of their masses. The fluid should then be cytologically
      examined for confirmation of its benign nature and repeat sonograms obtained to
      ensure that the mass has completely disappeared. Patients with masses appearing
      either solid or complex ultrasonographically should undergo surgical biopsy.

PMID- 1033183
TI  - Idiopathic hypertrophic subaortic stenosis: long-term surgical results.
AB  - The results of surgery in 21 patients with I.H.S.S. are reported. Dyspnea, angina
      pectoris and syncope were the most common symptoms in decreasing frequency.
      Before the operation, 5 patients were in New York Heart Association's functional
      class II, 10 in class III and 6 in class IV. The mean resting peak systolic
      pressure gradient was 66 mm Hg in 20 patients and mean left ventricular end
      diastolic pressure was 14 mm Hg in 19 patients. The ventriculoseptomyectomy
      accomplished through a transaortic approach is the procedure of choice. The
      operative mortality rate was 14% (3 of 21 patients). There were 2 late deaths
      from congestive heart failure. Any sudden death did not occur. The remaining 16
      patients have been followed up for a mean of 75 months (range 12 months to 11
      years), 11 patients are in functional class I, 4 in class II and 1 in class III.
      Complete left-bundle-branch block occurred in 3 patients. Our study with a long
      post-operative follow-up period, documents that surgery results in good to
      excellent alleviation of symptoms in survivors. The elevated pre-operative left
      ventricular end-diastolic pressure has a significantly poor prognosis. We
      currently recommend surgery for the symptomatic patients who have not responded
      to medical therapy, not late in the symptomatic course of the disease.

PMID- 1033184
TI  - Actin filament-membrane attachment: are membrane particles involved?
AB  - The association of actin filaments with membranes is an important feature in the
      motility of nonmuscle cells. We investigated the role of membrane particles in
      the attachment of actin filaments to membranes in those systems in which the
      attachment site can be identified. Freeze fractures through the end-on attachment
      site of the acrosomal filament bundles in Mytilus (mussel) and Limulus (horseshoe
      crab) sperm and the attachment site of the microvillar filament bundles in the
      brush border of intestinal epithelial cells were examined. There are no particles
      on the P face of the membrane at these sites in the sperm systems and generally
      none at these sites in microvilli. In microvilli, the actin filaments are also
      attached along their lengths to the membrane by bridges. When the isolated brush
      border is incubated in high concentrations of Mg++ (15 mM), the actin filaments
      form paracrystals and, as a result, the bridges are in register (330 A period).
      Under these conditions, alignment of the particles on the P face of the membrane
      into circumferential bands also occurs. However, these bands are generally
      separated by 800-900 A, indicating that all the bridges cannot be directly
      attached to membrane particles. Thus membrane particles are not directly involved
      in the attachment of actin filaments to membranes.

PMID- 1033185
TI  - Topography of the synaptosomal membrane.
AB  - The composition and disposition of the constituent polypeptides of rat cerebral
      cortical synaptosomal membranes were analyzed on SDS acrylamide gels. Of 20 bands
      readily detected, 11 account for greater than 93% of the total protein analyzed.
      These are: (molecu25); 3 (175); 4 (doublet, 137); 5 (doublet, 97); 6 (68); 7
      (61); 8 (54); 9 (44); 10 (37); and 11 (33). Bands 5 and 8-10 are the most
      prominent and account for greater than 60% of the protein mass or 0.67 of its
      molecular fraction. By lactoperoxidase iodination, the bulk of the proteins in
      bands 3, 5, 6, and 8 and a portion of band 11 appear to be located on the
      external (junctional) face of the membrane of intact synaptosomes; proteins in
      bands 1, 2, 7, 9, and 10 appear to be localized on the internal (synaptoplasmic)
      face and become labeled only when synaptosomes are lysed. Further confirmation of
      the topographical distribution is provided by evidence that bands 3-6, 8, and 11
      contain glycoproteins susceptible to labeling in intact synaptosomes by oxidation
      with galactose oxidase or periodate followed by reduction with NaB3H4. Evidence
      is provided for significant contributions by tubulin- and actin-like molecules to
      bands 8 and 9, respectively, suggesting that a substantial fraction of the
      tubulin in the synaptosomal membrane is disposed externally (accessible to
      iodination) whereas most, if not all, of the actin appears to exhibit the
      opposite topography. Similar though weaker inferences can also be drawn with
      regard to the location of tropomyosin and troponin. Preliminary evidence is
      provided that postsynaptic densities exhibit a protein and iodination profile
      distinct from that of the synpatosomal membrane.

PMID- 1033186
TI  - Association of microfilament bundles with lysosomes in polymorphonuclear
      leukocytes.
AB  - The juxtaposition of microfilament bundles and lysosomes seen both in thin
      sectioned cells in the transmission electron microscope and in cryofractured
      cells in the scanning electron microscope, and the presence of short filamentous
      structures between lysosomes and microfilament bundles, suggest that
      microfilaments may be attached to lysosomal membranes and that these filaments
      may be involved in lysosomal movements. Further work is in progress to test these
      hypotheses.

PMID- 1033187
TI  - A simple, selective method for freeze-fracturing spherical cells.
AB  - A simple and selective method for freeze-fracturing spherical cells is described.
      The cells are loaded into the holes of a thin nickel screen. A metal hat is
      applied to the cell monolayer and the whole assembly, hat-cells-screen, is frozen
      and then fractured by ripping the hat off. The fractured face on the screen is
      replicated. By varying the size of the screen holes and by applying the hat to
      either side of the screen, this method can selectively expose the E face (or the
      outer half of plasma membrane), the P face (or the inner half of the plasma
      membrane), or the cytoplasm of the cells. It also provides a means to produce
      fractures at a preselected area on the cell, if the cells can be loaded onto the
      screen in an oriented fashion.

PMID- 1033188
TI  - Actin polymerization and interaction with other proteins in temperature-induced
      gelation of sea urchin egg extracts.
AB  - The gel which forms on warming the extracts of the cytoplasmic proteins of sea
      urchin eggs has been separated into two fractions, one containing F-actin and the
      other containing two proteins of 58,000 and 22,000 mol wt. When combined in 0.1 M
      KCl, even at 0 degrees C, these components will form gel material identical to
      that formed by warming extracts. This gel is a network of laterally aggregated F
      actin filaments which are in register and which display a complex cross-banding
      pattern generated by the presence of the other two proteins. Low concentrations
      of calcium block the assembly of these proteins to form this complex structure,
      which may play some cytoskeletal role in the cytoplasm. This association of F
      actin with the other proteins to form a gel is very likely the last step fo the
      process occurring in warmed extracts. At low temperatures, gelation of extracts
      is limited by the relative absence of F-actin, as demonstrated by the inability
      to sediment it at 100,000 g and also by the fact that gelation occurs immediately
      if exogenous F-actin is added to cold extracts. The transformation of the G-actin
      present in the extract to the F-form is apparently repressed at low temperatures.
      This is shown directly by the failure of added G-actin to polymerize at low
      temperatures in the presence of extract. These observations resemble those which
      have been reported on preparations from amoeboid cells and may be significant in
      the involvement of actin and these other proteins in cell division and later
      developmental processes.

PMID- 1033189
TI  - An autoradiographic analysis of [3H]alpha-bungarotoxin distribution in the rat
      brain after intraventricular injection.
AB  - Purified alpha-bungarotoxin was isolated by chromatography and made radioactive
      with tritium ([3H]acetamidino-alpha-bungarotoxin). Infusions of [3H]alpha
      bungarotoxin alone or preceded by tubocurarine or atropine were given into the
      third ventricle. 2. 12, or 24 h after injection the brains were prepared for
      autoradiography. Injections of alpha-bungarotoxin (radioinert) in buffer, or of
      [3H]parathyroid hormone in buffer, served as controls. The various patterns of
      labeling suggest the presence of nicotinic-cholinergic neurons within the arcuate
      and basolateral regions of the hypothalamus including the supraoptic and
      suprachiasmatic nuclei and, in addition, the central nucleus of the amygdala.

PMID- 1033190
TI  - The distribution of anionic sites on the surface of the Golgi complex.
AB  - The distribution of anionic binding sites has been investigated in the isolated
      Golgi complex using cationic ferritin. The greatest density of anionic sites
      occurs on the tubular network and small vesicles, and this binding is accompanied
      by increased levels of galactosyltransferase activity. The density of anionic
      sites on the cisternae is less than on the tubules and shows anisotropic
      distribution, with higher density on the convex surface and lower density on the
      concave surface. The distribution of anionic sites may reflect the functional
      activity of the Golgi complex and possibly the interaction or cohesion between
      cisternae in this organelle.

PMID- 1033191
TI  - Revised constitution, absolute configuration, and conformation of griseoviridin,
      a modified cyclic peptide antibiotic.

PMID- 1033192
TI  - Amino-acids and peptides Part XVI. Synthesis of cyclo-[L-(alpha-amino)-beta
      alanylglycyl-D-(alpha-amino)-beta-alanylglycyl] and related fourteen-membered
      cyclotetrapeptides.

PMID- 1033193
TI  - Amino-acids and peptides. Part XVII. Synthesis of cyclo-[(O-t-butyl)-L-seryl-beta
      alanyl-glycyl-(O-methyl)-L-beta-aspartyl], and observations on the rearrangement
      of beta-aspartyl peptides esters.

PMID- 1033194
TI  - Amino-acids and peptides. Part XVIII. Studies relating to the synthesis and
      conformation of a novel bicyclic peptide system.

PMID- 1033195
TI  - The biosynthesis of fungal metabolites. Part IX. Sclerin: feedings with [1,2
      13C]acetate and[methyl-13C]methionine.

PMID- 1033196
TI  - Biosynthesis of natural products. Part 1. Incorporations of ent-Kaur-16-ene and
      ent-Kaur-16-en-15-one into enmein and oridonin.

PMID- 1033197
TI  - Studies on steroids. Part 37. Synthesis of the four stereoisomers of 20,22
      epoxycholesterol.

PMID- 1033198
TI  - Carotenoids and related compounds. Part XXXIV. Synthesis of violerythrin and
      other cyclopentenediones.

PMID- 1033199
TI  - New dibenz[d,f]azonine alkaloids from Cocculus laurifolius DC.

PMID- 1033200
TI  - Fusicoccin. Part 6. Biosynthesis of fusicoccin from [3-13C]- and (4R)-[4-3H]
      mevalonic acid.

PMID- 1033201
TI  - A highly stereospecific synthesis of (R)- and (S)-[2-3H]Glycine.

PMID- 1033202
TI  - Oxidation of some penicillins and other sulphides by use of a polymer-supported
      peroxy-acid.

PMID- 1033203
TI  - Preparation of glycerols protected at the 2-hydroxy-group and their application
      to the synthesis of lipids.

PMID- 1033204
TI  - Synthesis of 7,10- and 7,8-dimethylbenz[c]acridine.

PMID- 1033205
TI  - The socialization of 2-yr old boys: ecological findings.

PMID- 1033206
TI  - Electron-capture gas chromatographic determination of residues of anthraquinone
      bird repellent.

PMID- 1033207
TI  - Some additional observations on the analysis of glyceryl ethers and
      chromatographically related lipids.

PMID- 1033208
TI  - Translation and stability of human globin mRNA in Xenopus oocytes.
AB  - Human globin messenger RNA (mRNA) prepared from erythroid cells of patients with
      sickle cell anemia has been translated in Xenopus laevis oocytes. Addition of
      hemin to the injected mRNA causes total globin synthesis to increase and the
      ratio of alpha- to betas-globin synthesis (alpha/betas ratio) to approach unity.
      To determine the effect of the length of the poly-(A) segment on human globin
      mRNA stability, 10 S globin mRNA was fractionated into poly-(A)-poor fractions by
      oligo (dT)-cellulose column chromatography. When oocytes are injected with each
      of these fractions, translation of the poly-(A)-rich globin mRNA is sustained for
      a longer period than that of the poly-(A)-poor mRNA. Regardless of the mRNA
      fraction injected, the alpha/betas ratio of the synthesized globin decreases as
      the injected oocytes are incubated for longer periods. The results indicate that
      in frog oocytes poly-(A)-rich mRNA has greater translational stability than poly
      (A)-poor mRNA, AND beta-mRNA has greater stability than alpha-mRNA with
      comparable poly-(A) content.

PMID- 1033209
TI  - Umbilical uptake of amino acids in the unstressed fetal lamb.
AB  - The whole blood concentrations of 22 amino acids were measured in a chronic,
      unstressed fetal lamb preparations. Samples were taken daily from the umbilical
      artery, umbilical vein, and maternal artery over the latter quarter of gestation.
      73 sets of samples (from the umbilical artery and vein and the maternal artery)
      from 13 animals were analyzed for amino acid levels. Oxygen contents were
      determined simultaneously in 48 sets (umbilical artery and vein) to relate fetal
      oxygen consumption to amino acid uptake via the umbilical circulation. The
      results indicate that there is no umbilical uptake of the acidic amino acids,
      glutamate and aspartate; there is, in fact, a net flux of glutamate out of the
      fetus into the placenta. As both of these amino acids are major constituents of
      body proteins, the data indicate that they are formed within the fetus. The
      umbilical uptake of some neutral and basic amino acids (e.g., valine, leucine,
      isoleucine, arginine, phenylalanine, and tyrosine) is in considerable excess of
      estimated growth requirements, suggesting that some amino acids undergo extensive
      transamination and oxidative degradation in the fetus. Finally, the net uptake of
      nitrogen, carbon, and calories by the growing ovine fetus in the form of amino
      acids, glucose, and lactate is compared to estimated requirements as determined
      in previous studies.

PMID- 1033210
TI  - Motivated behaviors elicited from hypothalamus, midbrain, and pons of the guinea
      pig (Cavia porcellus).
AB  - Eating, drinking, biting attack, male mating behavior, and gnawing were elicited
      by electrical stimulation through electrodes located predominantly in a region
      extending from the preoptic area through the lateral hypothalamus into the
      ventral midbrain. Escape and digging were elicited from a parallel but more
      medial region that overlapped the lateral zone only in the preoptic-anterior
      hypothalamic area. Several differentiable vocalizations were produced from sites
      distributed through most, although not all, areas explored. Sites yielding
      painlike responses were located principally in the vicinity of the presumed pain
      pathway traced after anterolateral cordotomy in other species. Reward was
      obtained from widespread sites that were generally congruent with
      catecholaminergic systems as described in the rat. Although there was
      considerable overlap of the effective zones for many responses, their underlying
      mechanisms were differentiated anatomically by localized differences in their
      distribution or functionally by the elicitation of pure responses from some
      electrodes. Response mechanisms localized in the brain stem of the guinea pig
      generally resembled those in the rat, although there were differences in details,
      especially in the posterior midbrain and pons.

PMID- 1033211
TI  - Male-female differences and the influence of neonatal and adult testosterone on
      intraspecies aggression in rats.
AB  - Male and female albino rats were tested for intraspecies aggression without the
      use of shock. In the first experiment, male pairs showed more biting attacks,
      offensive sideways movements, and self-grooming than did female pairs; male pairs
      also showed more stereotyped defensive/submissive behaviors and were wounded more
      frequently. The second experiment examined the effects of neonatal castration and
      testosterone propionate (TP) administration on fighting. Males castrated at birth
      attacked other males less frequently than did controls when tested with TP
      treatment as adults. The TP given at birth to neonatally castrated males restored
      attacks to control levels. Females given TP as neonates did not differ from
      either male or female controls. Other aggressive/defensive behaviors, however,
      did not show this pattern. The results suggest that while the presence of
      testosterone during a brief postnatal period and during adulthood is necessary
      for attack behavior to occur, other related behaviors may not be affected in a
      similar manner.

PMID- 1033212
TI  - Feeding behavior of steers fed a complete mixed ration.
AB  - Feeding behavior of five Holstein steers fed a complete mixed ration was studied
      by use of individual, electronically controlled feeding behavior units. Both
      individual meal and daily behavioral parameters were measured. Number of meals,
      size of each individual meal, time spent eating, and intervals between meals were
      measured. Eating rates were then calculated. Diurnal feeding patterns were
      observed with 60.9% of the meals occurring between 0600 and 1800 h. For
      individual meals, body weight accounted for less than 30% of the variation in
      meal size. Average meal size was 414.5 g. Respective means for overall meal
      duration, actual meal duration, overall eating rate, and actual eating rate were
      20.3 min, 13.7 min, 23.1 g/min, and 30.0 g/min. Meal size per body weight (g/kg
      or g/kg.75) was relatively constant during observation. Both increased eating
      rate and increased meal length were associated with larger meals. However, eating
      rate tended to plateau while meal length continued to increase with larger meals.
      Steers consumed 10.01 meals per day while total daily overall meal duration and
      actual meal duration were 220.9 and 156.4 min.

PMID- 1033213
TI  - Rapeseed meal in complete feeds for dairy cows.
AB  - Three complete feeds containing low glucosinolate, low erucic acid rapeseed meal
      (Cultivar "1788"), high glucosinolate, low erucic acid rapeseed meal (Cultivar
      "Span"), or soybean meal as protein supplement were evaluated with lactating
      Holstein cows in a double 3 X 3 Latin square design. Lactation performance,
      hematology, blood chemistry, serum-free amino acids, rumen volatile fatty acid
      concentrations, and milk fatty acid composition were measured. The 1788 ration
      tended to increase yield of milk and of total solids. Hematology, blood
      chemistry, and serum-free amino acid data showed no differencein utilization of
      nitrogen. Concentrations of volatile fatty acids were not different. Feeding of
      the high glucosinolate Span ration did not reduce feed intake. However, there
      were indications that Span-fed cows may have experienced hypothyroidism. No
      differences were in erucic acid content of milk fat, and concentrations were low.
      Rapeseed meals 1788 and Span and soybean meal were equal as protein supplements.

PMID- 1033214
TI  - Selenium and vitamin E and incidence of retained placenta in parturient dairy
      cows.
AB  - In a 2 X 2 X 2 factorial experiment, protein intake, selenium supplementation,
      and intake of phosphorus were related to the incidence of retained placenta in
      cows fed varying concentrations of these nutrients during the dry period. The
      population incidence of 38% retained placenta in 26 control cows was independent
      of phosphorus intake which ranged between 39 and 95 g per day. When a protein
      supplement was included in the concentrate as soybean meal, the incidence of
      retained placenta was reduced to 20% for supplemented animals from 50% for the
      animals that received no soybean meal. This increased protein in the ration was
      reflective of a mean increase from .02 ppm of selenium to .06 ppm of selenium in
      the ration. By increasing the mean daily intake of selenium at least 3 wk
      prepartum from .23 mg to .92 mg daily, overall incidence of retained placenta was
      reduced from 38% to 0%. A positive prophylactic effect was achieved regardless of
      whether alpha tocopherol was supplemented as well. These mature dairy cows were
      deficient in selenium, and supplementation of selenium reduced the incidence of
      retained placenta.

PMID- 1033215
TI  - Amounts and sources of protein for dairy calves.
AB  - Female Holstein calves (178) were fed rations varying from 10 to 17% crude
      protein (air dry) from 30 to 102 days of age. Ten percent was inadequate
      resulting in less body weight, gain, withers height, and heart girth than rations
      containing 12 to 17% crude protein. In trial 1 addition of urea, biuret, or
      ammonia-molasses to a 12% diet to make a 16% crude protein diet allowed gains and
      weights indistinguishable from those on a 12 or 16% crude protein soybean meal
      ration. In another trial, addition of urea, biuret, or ammonium propionate to a
      10% ration to make a 14% ration allowed insignificantly greater gains and body
      weight. Gains and body weight were greater for the 14% soybean meal ration than
      the three non-protein-nitrogen rations for calves to 71 days of age but equal for
      71 to 102 days. Gain, body weight, dry matter, and protein intakes at most dates
      and intervals were greater for calves fed the 14% soybean meal ration than the
      10% ration. When 10, 12, 14, and 16% soybean meal rations were compared
      simultaneously, only the 10% crude protein ration gave inferior performance.
      Gains were reduced when average daily crude protein intake for the 72 day trail
      was 258 g or less. Calves fed lupine or dried poultry waste did not gain or
      consume as much as those fed comparable soybean meal rations. Calves fed a 17%
      crude protein ration from several protein sources plus alfalfa hay gained no much
      than those fed the 12 to 16% crude protein rations. Regression analysis relating
      dry matter and protein intake to body weight or gains indicated both dry matter
      intake and protein percentage were about equally important from day 41 to 72 and
      that after this age dry matter intake was of much greater importance than protein
      percentage. Protein intake expressed as g/day was not of importance in this
      regression. Weaning at day 42 allowed for greater body weight and gains than
      weaning at day 32. The difference in body weight was 2.5 kg at day 42 and 7 kg at
      day 102.

PMID- 1033216
TI  - Kinetic studies of the reduction of hemoglobin and myoglobin by chromium(II).

PMID- 1033217
TI  - Quality factors in beef, pork, and lamb cooked by microwaves.
AB  - Three cooking treatments were applied to the longissimus muscle of beef and of
      pork and to deboned leg of lamb. Cooking treatments included: Intermittent energy
      application (3-min. cycle) with a microwave range operated at 220V and
      intermittent energy application (6-min. cycle) with a microwave range operated at
      115V. Control roasts were cooked in a conventional gas oven (163+/-3 degrees C.).
      Cooking was adjusted so that roasts achieved an internal temperature of 70
      degrees C. when cut for analyses. Cooking losses were significantly greater for
      microwave than for conventionally cooked beef. However, microwave cooking
      resulted in beef, pork, and lamb roasts with flavor of interior portions similar
      to those prepared conventionally. Flavor differences in samples from the edge of
      the slices of lamb and of pork and tenderness of lamb appeared to be related to
      cooking method. For these attributes, meat cooked conventionally was superior. In
      contrast, patterns in significant differences in tenderness and juiciness of beef
      and of pork were not consistent and were not related solely to method of cookery.
      Neither creatine nor creatinine was a good index of flavor of meat cooked by
      these methods. Aside from the time-saving aspect of microwave heating, there was
      no major advantage of one method of cooking over another. Thus, either high- or
      low- powered microwave equipment, operated at 2450 MHz, can be used
      satisfactorily for cooking tender cuts of beef, pork, and lamb.

PMID- 1033218
TI  - Structural conflict and object relations conflict.
AB  - A hierarchical model of the mind is required for a more integrated understanding
      of psychic conflict. At a higher developmental level, the hierarchical model
      includes the tripartite model, and at a lower level it includes an object
      relations model. Psychic conflicts may be classified into object relations
      conflicts and structural conflicts. The object-relations class of psychic
      conflict covers the phase of psychic development prior to id-ego-superego
      differentiation. The earlier psychoanalytic writings tended to ascribe all kinds
      of symptoms, conflicts, and disorders to structural conflicts. Logical and
      empirical evidence against the universality of structural conflicts in various
      disorders and symptoms, even psychoneurotic symptoms, has been summarized and
      discussed.

PMID- 1033219
TI  - Aspiculuris tetraptera in wild Mus musculus. Age resistance and acquired
      immunity.
AB  - Wild house mice, naturally infected with Aspiculuris tetraptera were segregated
      according to their weight into six age groups. The prevalence of infection and
      the mean worm burden of these mice were studied in the different age groups. The
      overall prevalence of infection was high (57% or more) in all the groups except
      the youngest. Mice acquired larvae soon after weaning; the highest larval burdens
      were reached in juvenile mice and the highest mature worm burdens, a group later,
      in mature mice. Older mice had fewer larvae and fewer mature worms. The mature
      worm burdens decreased but relatively slower than the larval burdens. It is
      suggested that eigher innate or acquired resistance could account for these
      observations.

PMID- 1033220
TI  - [Disinfection of sewage waters from rendering plants with peracetic acid].
AB  - In our experiments, peracetic acid--known in commerce as "Wolfasteril" was tested
      as a new and efficient disinfectant to disinfect sewage waters from rendering
      plants. Peracetic acid was used in experiments in concentration of 0.1 to 1.0%
      for 30 sec. to 60 min. As a comparative agent, 5% chloramine was used. Results
      obtained in preliminary and main experiments proved that peracetic acid is fully
      appropriate to disinfect biologically cleaned sewage waters in rendering plants.
      Sewage waters supplying the main stream has to pass mostly a short section after
      having left the water clarifier. Consequently, the concentration of 1% peracetic
      acid acting for 30 sec. is the optimum one. The recommendation of this
      application norm for peracetic acid in water clarifiers from rendering plants
      being at least suitable in controlling disasters.

PMID- 1033223
TI  - Assessment of effectivity of oral killed typhoid and paratyphoid B vaccines and
      aerosol chemical typhoid vaccine in controlled field trials.
AB  - A total of 3 controlled field trials were carried out. One of them (1963) showed
      that aerosol chemical typhoid vaccine did not protect vaccinated subjects from
      the disease. Two other tests (1964 and 1965) assessing the effectivity of killed
      orally administered typhoid vaccine revealed a short term (up to 3 months)
      protective effect expressed by an effectivity coefficient of 45%, fiducial limits
      being 8-70%. In the assessment of oral paratyphoid B vaccine, the difference in
      morbidity in the experimental and control groups was statistically insignificant
      due to a small number of cases of disease.

PMID- 1033224
TI  - Genus Microsporum dermatophytes in eastern Bohemia.
AB  - The authors presented a taxonomic survey of dermatophytes of the genus
      Microsporum. From the 19 species described so far, they isolated ten species in
      the region of Eastern Bohemia. Only the species Microsporum cookel and M. gypsem
      are considered to be endemic species. The remaining are regarded as imported
      dermatophytes which are not able to maintain their existence permanently in the
      conditions of the mentioned region. Data on the findings of the individual
      species were completed by the authors' remarks on their primary hosts and/or
      substrates of heterotrophy, frequency of occurrence and geographical
      distribution.

PMID- 1033225
TI  - Reliability of the serological method of examination as a basis for diagnosis of
      associated respiratory virus infections.
AB  - The reliability of the results of serological examination in diagnostics of
      associated infections was studied on a model of artificially provoked vaccinal
      infections in humans and in laboratory animals. The effect of administered
      monopreparations on changes in the level of both homologous and heterologous
      antibodies was tested. The character of immunological changes following
      simultaneous administration of two or more respiratory viruses was analysed and
      the effect of these viruses in diseases of divers etiology was studied. According
      to the results of experiments on laboratory animals, repeated administration of
      any of the earlier used respiratory viruses stimulated the accumulation of only
      homologous antibodies while heterologous antibodies did not increase at all. The
      results revealed the possibility of simultaneous immunological reorganization of
      a child's organism in response to the influence of several different antigens
      from the group of respiratory viruses acting synchronously or in succession.
      Results of the analysis demonstrated the reliability of the employed serological
      methods of diagnosis of respiratory virus infections.

PMID- 1033226
TI  - A note on single- and two-dose immunogenicity tests of inactive virus vaccine in
      chicks.
AB  - Single dose extinction limit test ot inactive polio vaccine in chicks lasts 4
      days and offers the same results as the two-dose test which requires 14 days.
      When "long-term" incubation instead of "conventional" 2 hours-incubation of the
      serum/virus mixtures in the neutralization reaction was used, extinction limit
      values higher by 0.6-0.7 log10 were regularly obtained.

PMID- 1033228
TI  - Human infections caused by V. parahaemolyticus in Czechoslovakia.
AB  - Vibrio parahaemolyticus was isolated in two subjects with acute gastroenteritis.
      The patients history included stay in Pakistan or India. They probably contracted
      the infection on board an aeroplane where they ingested cold meal containing sea
      products. The possibility of this conditioned pathogen occurring also in an
      inland country is pointed out.

PMID- 1033230
TI  - Isolation of antibody-forming cells by using cluster formation in combination
      with velocity sedimentation.
AB  - A method is described for isolation of antibody-forming cells with the help of
      cluster formation. This was achieved by incubating spleen cells from immunized
      mice with sheep erythrocytes at 37 degrees C. During incubation rabbit-anti-mouse
      immunoglobulin serum was present in order to facilitate the formation of
      clusters. Thereafter the clusters were isolated by velocity sedimentation. In
      this way we obtained suspensions containing more than 80% clusters. Some of the
      cells in the clusters still produced antibodies against sheep erythrocytes
      cultured for two days in vitro.

PMID- 1033231
TI  - Quantitative alterations in the genital microflora of female rats in relation to
      the estrous cycle.
AB  - The virgin female laboratory rat has been studied as a model of the ecosystem
      represented by the vaginal mucosa and its bacterial flora. Gram-stained vaginal
      smears abtained from rats having normal estrous cycles showed cyclic variation in
      the number of bacteria present. Viable plate counts of material obtained by
      vaginal lavage demonstrated daily changes in the density of the bacterial
      population of the vagina in relation to the estrous cycle. Bacterial counts
      observed during the estrus phase of the cycle in individual rats were 10,000 to
      100,000 times greater than viable counts observed during the metestrus or
      diestrus phases of the cycle. These studies represent the first reported
      demonstration that physiologic changes occurring during the estrous cycle control
      the size of the bacterial population of the vagina.

PMID- 1033232
TI  - [3 cases of congenital diaphragmatic eventration in infants and review of 55
      surgical cases in Japan].

PMID- 1033233
TI  - [Follow-up studies of 2-staged surgery for ventricular septal defect associated
      with severe pulmonary hypertension].

PMID- 1033234
TI  - [Diagnosis and management of left atrial myxoma].

PMID- 1033235
TI  - [Clinical significance of the differences between pulmonary arterial end
      diastolic and left atrial pressure following mitral valve surgery].

PMID- 1033236
TI  - [Studies of heart pacemaking--heart rate, cardiac output curve and intracardiac
      pressure].

PMID- 1033237
TI  - [Significance of the diameter of the peripheral pulmonary arteries in the
      corrective surgery of tetralogy of Fallot].

PMID- 1033238
TI  - [Corrective surgery of tetralogy of Fallot and associated problems].

PMID- 1033239
TI  - [Pathophysiology of giant bulla and improvement following surgery].

PMID- 1033240
TI  - [Clinical significance of regional lung function tests. Relationship between
      regional lung function test with 133Xe and total lung function test].

PMID- 1033241
TI  - [Experimental studies on coronary artery perfusion in heart surgery].

PMID- 1033242
TI  - [Postoperative course following mitral commissurotomy--lung scintigraphy].

PMID- 1033243
TI  - [Evaluation of mitral commissurotomy in 5- to 15-year follow-up].

PMID- 1033244
TI  - [Surgical experiences with ventricular septal defects in 272 cases].

PMID- 1033245
TI  - [Persistent left superior vena cava and management of its blood flow--studies of
      safety of simple occlusion during extracorporeal circulation and simple ligation
      in cases with drainage into the left atrium].

PMID- 1033246
TI  - [Changes of serum enzyme activities associated with open heart surgery with
      extracorporeal circulation--changes of serum GOT, LDH, CPK and amylase levels].

PMID- 1033247
TI  - [Effect of steroid administration during extracorporeal circulation reflected on
      the distribution of systemic circulation].

PMID- 1033248
TI  - [Experimental studies on partial pressure of muscle tissue during extracorporeal
      circulation].

PMID- 1033249
TI  - [Pituitary-testicular function after thoracic surgery].

PMID- 1033250
TI  - [Protective effects of betamethasone during open heart surgery].

PMID- 1033251
TI  - [Lipid metabolism in hemorrhagic shock and pulmonary failure].

PMID- 1033252
TI  - [Transapical aortic perfusion with a double-barreled cannula--experimental study
      and clinical application].

PMID- 1033253
TI  - [Bronchoplasty in surgical management of lung neoplasms].

PMID- 1033254
TI  - [Successful management of impending cardiac rupture].

PMID- 1033255
TI  - [Successful correction of preductal coarctation of the aorta associated with
      ductal arteriosus, ventricular septal defect and severe pulmonary hypertension].

PMID- 1033256
TI  - [Localized mesothelioma of the pleura in Japan--with special reference to our 2
      cases].

PMID- 1033257
TI  - [Immobilized enzymes].

PMID- 1033258
TI  - [Heat-resistant mechanism of the cellular components of thermophilic bacteria].

PMID- 1033259
TI  - [O'Farrell's 2-dimensional electrophoresis].

PMID- 1033260
TI  - Endotoxin and prevention of hypoxic pulmonary vasoconstriction.
AB  - Endotoxin is known both to stimulate prostaglandin production and to abolish the
      pulmonary vascular pressor response to hypoxia. The present study demonstrated
      that two inhibitors of prostaglandin synthesis, meclofenamate and indomethacin,
      prevent loss of pulmonary vasoconstriction due to hypoxia when sublethal doses of
      endotoxin are administered. This suggests that endotoxin may stimulate the
      production of a dilator prostaglandin which would oppose the hypoxic
      vasoconstriction, but other ways in which these inhibitor drugs might act are
      considered. Endotoxin damages platelets and leukocytes, both of which can form
      prostaglandins and could be the source of a dilator prostaglandin. However, in
      these experiments endotoxin abolished the hypoxic pressor response in dogs
      rendered severely thrombocytopenic by platelet antiserum. This suggests that
      platelets are not involved. In further experiments blood from anesthetized dogs
      was circulated through glass bead columns. Changes in the leukocyte count
      following perfusion were correlated with changes in the subsequent pressor
      response to hypoxia. The possibility that leukocytes may be involved in the
      effect of endotoxin on the hypoxic pressor response is considered.

PMID- 1033261
TI  - Sterol content of the Myxomycetes Physarum polycephalum and P. flavicomum.
AB  - The sterol content of two Myxomycetes, Physarum polycephalum and P. flavicomum
      has been examined. The sterols of the two species are apparently identical, the
      two major sterols in each being poriferasterol and 22-dihydroporiferasterol.
      Threee minor sterols are probably delta5-ergostenol, ergostanol, and
      poriferastanol. The triterpenoids of the two species differ in that, though
      lanosterol was identified in both, 22-dihydrolanosterol was indicated only in P.
      flavicomum. The occurrence of lanosterol together with a typical mixture of plant
      sterols is somewhat unusual.

PMID- 1033262
TI  - The general occurrence of mitochondrial nuclei in the true slime mold.

PMID- 1033263
TI  - Electron microscopic studies on macrophages. I. Effects of colchicine and
      cytochalasin B on the cell cortex as revealed by scanning electron microscopy.

PMID- 1033264
TI  - Occurrence of Birbeck granules in the macrophage of mouse lymph nodes.

PMID- 1033265
TI  - Passive potassium transport in LK sheep red cells. Effects of anti-L antibody and
      intracellular potassium.
AB  - The passive K influx in low K(LK) red blood cells of sheep saturates with
      increasing external K concentration, indicating that this mode of transport is
      mediated by membrane-associated sites. The passive K influx, iMLK, is inhibited
      by external Na. Isoimmune anti-L serum, known to stimulate active K transport in
      LK sheep red cells, inhibits iMLK about twofold. iMLK is affected by changes in
      intracellular K concentration, [K]i, in a complex fashion: increasing [K]i from
      near zero stimulates iMLK, while further increases in [K]i, above 3 mmol/liter
      cells, inhibit iMLK. The passive K influx is not mediated by K-K exchange
      diffusion. The effects of anti-L antibody and [K]i on passive cation transport
      are specific for K: neither factor affects passive Na transport. The common
      characteristics of passive and active K influx suggest that iMLK is mediated by
      inactive Na-K pump sites, and that the inability to translocate Na characterizes
      the inactive pumps. Anti-L antibody stimulates the K pump in reticulocytes of LK
      sheep. However, anti-L has no effect on iMLK in these cells, apparently because
      reticulocytes do not have the inactive pump sites which, in mature LK cells, are
      a consequence of the process of maturation of circulating LK cells. The results
      also indicate that anti-L alters the maximum velocity of both active and passive
      K fluxes by converting pumps sites from a form mediating passive K influx to an
      actively transporting form.

PMID- 1033266
TI  - Ultrastructure of an indigotin-producing dome mutant of Schizophyllum commune.
AB  - Electron microscopic observations of an indigotin-producing dome mutant of
      Schizophyllum commune Fr. have shown that large wall ingrowths occur within the
      hyphae. These ingrowths are coupled with morphological abnormalities produced by
      the dome mutation. The pigment indigotin appears to be produced by progressive
      condensation within vacuoles and to a lesser extent within the wall ingrowths.
      Cytochemical techniques have shown that the wall ingrowths are similar in
      structure to the hyphal walls. there was no evidence for the passage of condensed
      indigotin into the medium; the pigment granules found in the medium must
      therefore form outside the hyphae.

PMID- 1033267
TI  - Studies on basidiospore development in Schizophyllum commune.
AB  - The time required for synthesis of the spore components and the effect of
      different environmental conditions on basidiospore production were studied in the
      basidiomycete Schizophyllum commune. Both exogenous glucose and storage materials
      were used in the synthesis of spore components, which took 40 to 45 h to
      complete. A temperature of 30 degrees C, the presence of 5% CO2, a continuous
      supply of glucose, or a lack of exogenous glucose, had no effect on the rate of
      spore production. Light, however, was required for sporulation. Darkness
      inhibited sporulation between karyogamy and the initiation of meiosis: complete
      inhibition occurred after 48 h in the dark. Spores were produced 5 h after
      release from dark inhibition.

PMID- 1033268
TI  - Genetic analysis of radiation-sensitive mutations in the slime mould
      Dictyostelium discoideum.
AB  - The linkage of two mutations leading to increased sensitivity to ultraviolet
      light and 60Co gamma rays was determined in the slime mould Dictyostelium
      discoideum using a genetic analysis based on the parasexual cycle. Diploids were
      selected from a mixture of radiation-sensitive, temperature-resistant and
      radiation-resistant, temperature-sensitive haploids on the basis of simultaneous
      radiation and temperature resistance. Analysis of drug-resistant haploid
      segregants of the heterozygous diploids indicated that one of the radiation
      sensitive mutations, radA20, was linked to linkage group I whereas the other,
      radB13, was linked to the recently defined linkage group VI.

PMID- 1033269
TI  - Purification of two components of mouse L cell interferon: electrophoretic
      demonstration of interferon proteins.
AB  - Mouse L cell interferon induced by Newcastle disease virus was purified by the
      procedure described previously (Yamamoto et al. 1974) followed by gel filtration.
      The two fractions obtained containing interferon species S (36000 daltons) and F
      (24000 daltons), respectively, were analysed electrophoretically at pH 4-3, or in
      the presence of sodium dodecyl sulphate (SDS) at pH 7-2. In both fractions,
      interferon activity was invariably associated with distinct protein bands. In the
      F-containing fraction there were essentially no other proteins, and in the S
      containing fraction, impurity proteins were well separated from the interferon
      activity. The apparent mol. wt. determined by SDS-gel electrophoresis showed
      little or no dependence on gel concentration, suggesting that the interferons had
      low carbohydrate contents, and did not change after reduction with thiol reagents
      in SDS and urea.

PMID- 1033270
TI  - The production and action of interferon in Chinese hamster cells.
AB  - The interferon system has been investigated in primary cell cultures established
      from Chinese hamster embryos and new born pups. Interferon synthesis was induced
      with Sindbis virus, ultraviolet inrradiated Newcastle disease virus (u.v.-NDV)
      and with polyriboinosine acid-polyribocytidylic acid complex [poly (rI). poly
      (rC)]. Only u.v.-NDV induced significant production of interferon, maximum
      amounts being produced in 'aged' cells. Its apparent mol. wt. was 25000. CHO-KI
      cells, an established line of Chinese hamster cells, did not synthesize
      interferon in response to viruses, but were sensitive to its action.

PMID- 1033271
TI  - A survey of Rorschach teaching in APA-approved clinical graduate programs.
AB  - A questionnaire on teaching of the Rorschach technique was sent to all APA
      approved graduate clinical psychology programs in the United States and Canada.
      The questionnaire asked for the degree of emphasis placed on the Rorschach in the
      primary assessment course, the Rorschach teaching experience of the respondent
      and the respondent's evaluation of the technique as a clinical tool, a teaching
      aid and a research instrument. The respondent in each case was the faculty member
      teaching the major diagnostic assessment course. There was a 100% return of the
      questionnaires. The major results show that (1) 81% of the programs place major
      emphasis on the Rorschach Technique in the assessment course; (2) only 24% of the
      programs offer the course for a full year; (3) respondents with more than 10
      years teaching experience rated the Rorschach higher than respondents with less
      experience, and (4) respondents as a group rated the Rorschach highly as a
      clinical tool and teaching aid, but gave it generally low ratings as a research
      instrument.

PMID- 1033272
TI  - Systems approach to vaginal delivery of drugs III: Simulation studies interfacing
      steroid release from silicone matrix and vaginal absorption in rabbits.
AB  - A composite physical model involving the simultaneous receding boundary release
      of drug from a drug suspension-silicone polymer matrix system, diffusion across
      the aqueous layer, and passive transport across the vaginal membrane consisting
      of parallel lipoidal and aqueous pore pathways is described. Simulation studies
      with progesterone and hydrocortisone illustrate matrix release-limiting, membrane
      absorption, and aqueous diffusion layer-limiting cases when the cylindrical
      silicone delivery device is interfaced with the vaginal membrane of the rabbit.

PMID- 1033273
TI  - Caffeine in plasma and saliva by a radioimmunoassay procedure.
AB  - Caffeine was analyzed in human plasma and saliva by a simple, rapid, and
      sensitive radioimmunoassay procedure. Immunization of rabbits with an antigen
      prepared by coupling 7-(5-carboxypentyl)-1,3-dimethylxanthine to bovine serum
      albumin resulted in the formation of antibodies selective for caffeine as opposed
      to various mono- and dimethylxanthines, mono-, di-, and trimethyluric acids and a
      variety of common drugs. The radioligand used for competitive binding studies was
      7-(2,3-3H2-propyl)-1,3-dimethylxanthine. The procedure permits direct analysis of
      caffeine in plasma or saliva without extraction. Comparison with a high pressure
      liquid chromatography method for the analysis of caffeine gave satisfactory
      results and showed no evidence for interference by metabolites. A caffeine half
      life of 4.0 hours determined by the radioimmunoassay was in agreement with
      previous work. Comparison of human plasma and saliva levels by the
      radioimmunoassay procedure indicated approximately equal concentrations in the
      two fluids.

PMID- 1033274
TI  - [Thymus, peripheral lymphoid tissues and immunological responsiveness of the
      pituitary dward mouse (author's transl)].
AB  - Snell's pituitary dwarf mice (dw) were used for studies on the relationship
      between hypophysis and lymphoid organs. The age-dependent changes of thymus or
      spleen weights of dwarf mice were compared with those of normal littermates. The
      suppression of growth of the thymus or spleen in dwarf mice was recognized at 5th
      day of age. Although involution of the thymus varied among animals, a strong
      positive correlation was demonstrated between relative thymus weight and body
      weight in 30 approximately 40 days old dwarf mice. Lymphoid organs of dwarf mice
      were reconstituted by injection of growth hormone and or thyroxin. Relative
      thymus weight significantly increased in dwarf mice when the treatment with
      growth hormone started at 7 days of age, but the same treatment at 3 months of
      age did not show any effect on the increment of relative thymus weight. On the
      other hand, the antibody-forming capacitiy against sheep erythrocytes of dwarf
      mice was significantly increased even when the treatment with growth hormone was
      started at 3 months of age. A marked increase in the number of lymphoid cells in
      dwarf mice was observed by treatment with thyroxin, even if treatment was started
      either at 7 days or 3 months of age. Similar changes were also obtained in the
      antibody-forming capacity.

PMID- 1033275
TI  - Late positive potential of the flash-evoked response in the rabbit under deep
      anesthesia.

PMID- 1033276
TI  - A twin and family study of personality in young children.
AB  - Emotionality, activity, sociability and impulsivity (EASI) and components of each
      trait were studied in a sample of 137 pairs of young twins (two to six years of
      age) and their parents (548 individuals). Parents rated themselves and their
      spouses on an adult version of the EASI Temperament Survey and rated both of
      their twins on a child version of the EASI. Patterns of both identical and
      fraternal twin correlations (twin study) and parent-child correlations (family
      study) were consistent with the hypothesis that the EASI traits are influenced by
      genetic factors, but the two studies disagreed in the magnitude of that
      influence.

PMID- 1033277
TI  - Studies on the equine placenta II. Ultrastructure of the placental barrier.
AB  - In early pregnancy the equine placenta consists of a simple apposition of fetal
      and maternal epithelia, but it becomes more complex with the formation of
      microcotyledons between 75 and 100 days of gestation. Although the placental
      barrier maintains an epitheliochorial arrangement throughout the course of
      pregnancy, a thinning of the maternal epithelium and a progressive indentation of
      the chorionic epithelium by fetal capillaries shortens the length of the
      diffusion pathway and reduces the amount of placental tissue between fetal and
      maternal bloodstreams. These structural modifications may reflect the changing
      requirements of the fetus for O2 and other metabolites as gestation proceeds.
      During the first 200 days of pregnancy there is evidence of intense pinocytotic
      activity by the cells of the trophoblast. From the 100th day of pregnancy there
      is a pronounced development of smooth endoplasmic reticulum, while rough
      endoplasmic reticulum and irregular, dense, membrane-bound bodies are a prominent
      feature of the paranuclear cytoplasm from Day 200. These changes suggest that the
      cells of the trophoblast become more highly involved in synthetic processes with
      increasing gestational age.

PMID- 1033278
TI  - Effect of intravasal copper on the fertility of rats.
AB  - Copper wire was inserted into the vas deferens and its effect of the reproductive
      system and fertility performance of rats was investigated. The copper wire was
      100% effective as a contraceptive for up to 4 months if placed correctly, and
      resulted in decapitation of most of the spermatozoa. No differences between the
      rats with an intravasal copper wire and the sham-operated controls were found for
      the weights of the gonads and accessory sex glands or for protein, RNA, DNA and
      fructose concentrations. The intravasal copper device appears to be promising for
      the development of a long-term method for male contraception.

PMID- 1033279
TI  - The effect of indomethacin on uterine contractility and luteal regression in
      pregnant rats at term.
AB  - Treatment of pregnant rats with 1 mg indomethacin/kg twice daily i.m. beginning
      on Day 20 delayed the onset of parturition by about 21 hr and prolonged the
      duration of spontaneous parturition by 4 hr. Plasma progesterone and oestradiol
      levels were determined in daily samples of peripheral blood, and uterine
      contractions were recorded before and during parturition by means of small,
      chronically implanted intrauterine balloons which were connected to pressure
      transducers via fluid-filled catheters. Indomethacin treatment did not inhibit or
      suppress spontaneous or oxytocin-induced contractions, which were of the same
      intensity in indomethacin-treated as in control rats. Parturition was induced
      with oxytocin in the same proportion of treated and control rats, but its
      induction was not successful in treated rats until 1 day later than in control
      rats, but its induction was not successful in treated rats until 1 day later than
      in controls. The onset of parturition was always related to the plasma
      progesterone level, which declined at a slower rate in indomethacin-treated than
      in control rats, reaching baseline values approximately 1 day later in the
      treated animals. The appearance of 20alpha-hydroxysteroid dehydrogenase in the CL
      of pregnant rats normally occurs on Day 21 of gestation, but activity was not
      observed until about 1 (0-3) day later in the indomethacin-treated rats,
      indicating that luteolysis was retarded. Prostaglandin F-2alpha infusions given
      on Day 21 reversed the effects of indomethacin treatment on plasma progesterone,
      luteal 20alpha-hydroxysteroid dehydrogenase activity and the timing and duration
      of parturition, and reduced the high perinatal mortality associated with
      indomethacin treatment, suggesting that the effects of indomethacin were related
      to its inhibitory action on prostaglandin synthetase activity. It is concluded
      that, in rats, indomethacin exerts its effects on parturition through inhibition
      of luteal regression which was significantly retarded but not prevented, and that
      indomethacin does not have a direct effect on myometrial contractility.

PMID- 1033280
TI  - Concentration of steroids in bovine peripheral plasma during the oestrous cycle
      and the effect of betamethasone treatment.
AB  - Testosterone, oestradiol and progesterone were measured in peripheral plasma
      during the oestrous cycle of 6 heifers. Oestradiol and progesterone results
      confirmed earlier reports. Concentration of testosterone on the day of oestrus
      was 40+/-3 pg/ml (mean+/-S.E.M.), and two peaks were detected during the cycle,
      one 7 days before oestrus (1809+/-603 pg/ml) and the other (78+/- 7 pg/ml) on the
      day before the onset of oestrus. The concentration of progesterone declined in
      most cases 1 day after the maximum concentration of testosterone. Betamethasone
      treatment in 5 heifers extended luteal function by an average of 10 days: plasma
      androstenedione and oestradiol concentrations were unaltered; cortisol values
      were depressed for at least 16 days after treatment; testosterone concentrations
      were lowered by 13+/-2-4% during treatment, and except in one heifer the peak on
      Day -7 was abolished.

PMID- 1033281
TI  - Sialic acid and hexosamine concentrations in cervical nucus in different breeds
      of cows and buffalo at estrus.

PMID- 1033282
TI  - Masculinization in male rats is inhibited by neonatal injections of
      dihydrostestosterone.

PMID- 1033283
TI  - Progestagen dynamics in preovulatory follicles of rats.

PMID- 1033284
TI  - Induction of regression in the ovine corpus luteum by ICI 80,996, an analogue of
      prostaglandin F-2alpha.

PMID- 1033285
TI  - Luteal function and oestrus in gilts treated with a synthetic analogue of
      prostaglandin F-2alpha (ICI 79,939) at various times during the oestrous cycle.

PMID- 1033286
TI  - Control of oestrus and fertility in gilts with accessory corpora lutea by
      prostaglandin analogues, ICI 79,939 and ICI 80,996.

PMID- 1033287
TI  - Differential inhibition of trophoblast outgrowth and inner cell mass growth by
      actinomycin D in cultured mouse embryos.
AB  - Treatment of preimplantation mouse embryos in vitro with 10(-3) to 10(-1) mug
      actinomycin D/ml for 2 hr showed that (i) postimplantation development in vitro
      was inhibited most when embryos were treated at the morula stage and (ii) after
      the morula stage actinomycin D inhibited trophoblast outgrowth less than inner
      cell mass development.

PMID- 1033288
TI  - Parentrovite as a supportive therapy for locomotory stress in tsessebe.
AB  - Parentrovite was administered to tsessebe as supportive therapy against
      artifically induced locomotory stress. An attempt was made to judge the efficacy
      of this treatment from enzyme levels such as that of LDH. Other parameters such
      as systemic blood pressure and the ECG were also recorded. No significant
      differences were established between treated and untreated animals although LDH
      levels were considerably higher in the untreated than in the treated group. The
      small numbers of tsessebe available and the artifical nature of the exercise
      induced made an evaluation of the effectiveness of Parentrovite in the treatment
      of locomotory or of capture stress uncertain.

PMID- 1033289
TI  - Discolouration of wool: 1 green discolouration.
AB  - Since 1974 green bacterial discolouration of Merino wool was frequently
      encountered in the Karoo and Eastern Cape areas. The occurrence of this condition
      coincided with the extraordinary wet conditions that prevailed during this
      period. Pseudomonas aeruginosa was recovered in almost pure culture from affected
      wool of 24 out of 25 different sheep. The role played by this particular organism
      was fonfirmed by the successful reproduction of this condition after exposure of
      unaffected sheep to cultures of Ps. aeruginosa isolated from green wool.

PMID- 1033290
TI  - Analogues of 8-azaguanosine.
AB  - Two routes for the synthesis of 6-substtituted 8-azaguanosine analogues are
      described. 2,5,6-Triamino-4(3H)-pyrimidinethione (1) was converted by
      methylation, nitrosation, and acetylation to -n-acetyl-7-(methylthio)-3H-1,2,3
      triazolo[4,5-d]pyrimidin-5-amine (5). The reaction of 5 with 2,3,5-tri-O-acetyl-D
      ribofuranosyl chloride gave a mixture of the 7-, 8-, and 9-(2,3,5-tri-O-acetyl
      beta-D-ribofuranosyl)-8-azapurines 4a-c which was converted to 8-azaguanosine
      (7c) and the corresponding 7- and 8-substituted isomers 7a and 7b. 4a-c were also
      converted with NaOMe to 6-O-methyl-8-azaguanosine (8c) and to the corresponding 7
      and 8-substituted isomers 8a and 8b. The preferred route, however, to 6
      substituted 8-azaguanosine analogues is an unambigous synthesis through N2-acetyl
      6-(benzylthio)-N4-(2,3-O-isopropylidene-beta-D-ribofuranosyl)-5-nitro-2,4
      pyrimidinediamine (13), prepared from the reaction of the chloropyrimidine 10
      with the aminoribose 11. Catalytic hydrogenation of 13 gave the aminopyrimidine
      14, which was converted with nitrous acid to the nucleoside beta-20. Treatment of
      beta-20 with dilute acid gave 7-(benzylthio)-3-beta-D-ribofuranosyl-3H-1,2,3
      triazolo[4,5-d]pyrimidin-5-amine (19). Replacement of the benzylthio group of 19
      with various nucleophilic reagents gave 8-aza-6-thioguanosine 17 and analogues
      8c, 15, and 16. The thione 17 rearranges in  aqueous solution to the
      thiasiazolopyrimidine 21. The parent [1,2,3]thiadiazolo[5,4-d]pyrimidine-5,7
      diamine (24a) was prepared by nitrosation of the triaminopyrimidine (23a).
      Rearrangement of 24a in the presence of base gave a high yield of the thione 25a
      which could be rearranged with heat to 24a. Compounds 8a-c, 15-19, 24a, and 25 a
      were evaluated in the L1210 mouse leukemia screen- Only one compound, 8c, showed
      high cytotoxicity and borderline L1210 activity resulting from its en,ymatic
      conversion to 8-azaguanosine.

PMID- 1033291
TI  - Binding characteristics of M and L isoantibodies to high and low potassium sheep
      red cells.
AB  - Binding of highly purified 125I labeled M and L antibodies, both belonging to the
      immunoglobulin G class, was studied in high potassium (HK) and low potassium (LK)
      sheep red cells. Anti-M and anti-L bound specifically to M and L antigen positive
      HK and LK red cells, respectively. Nonspecific binding was higher for anti-L to
      HK cells than for anti-M to LK cells. Once bound, the M and L antibodies were
      capable of inducing complement dependent immune hemolysis. Only 75-100 and 500
      750 molecules of anti-M and anti-L immunoglobulins were required to hemolyze 50%
      of HK (MM) and LK (LL) red cells, respectively, suggesting that the M and L
      antigens may be clustered on the surfaces of these cells. Equilibrium binding
      studies revealed that the maximum number of M sites is 3-6 x 10(3) in HK (MM) and
      1.5-4 x 10(3) in LK (LM) cells, respectively. In comparison, the number of L
      antigens is slightly lower in LK cells, about 1.2-1.8 x 10(3) in LL and less in
      LM(LK) red cells. The number of M and L antigens, therefore, is more than an
      order of magnitude larger than that of the Na+K+ pumps measured previously in
      these cells by 3H-ouabain binding, thus precluding a quantitative correlation
      between M and L antigens and the Na+K+ pumps different in the three genetic types
      of sheep red cells. The binding affinities of both anti-M and anti-L could not be
      described by a single equilibrium dissociation constant indicating heterogeneous
      antibody populations and /or variability in the antigenic sets of individual HK
      or LK cells. The pronounced heterogeneity of antigens and/or antibodies in both
      the M and L systems was reflected in the antibody association kinetics, which
      also exhibited a remarkable temperature dependence. The data suggest that the
      correlation between the M and L antigens and the Na+K+ pump molecules is more
      complex than that in goat red cells previously reported by others.

PMID- 1033292
TI  - Electrophysiological properties of tissue cultured heart cells grown in a linear
      array.
AB  - Embryonic chick heart cells were grown in tissue culture on an oriented substrate
      (channels cut in an agar coated slide), so that they formed narrow(5-100mu)
      strands of arbitrary length. The electrical properties of these strands were
      examined using intracellular microelectrodes. ac and dc cable studies were
      performed to determine the passive cable parameters. Quantitative histology,
      using light and electronmicroscopy, permitted calculation of intrinsic
      capacitances and resistivities. Electrical coupling between polarizing and
      recording electrodes was ubiquitous, falling off exponentially with distance. It
      was concluded that individual cells were electrically connected, since coupling
      was observed at distances greater than 3 mm, and the maximum cell length was
      estimated to be less that 300 mu. The strands were usually spontaneously active,
      with phase 4 depolarization (pacemaker potential) occurring almost simultaneously
      in all cells of a strand. The passive electrical properties determined during
      phase 4 were: core resistivity (cytoplasm plus cell-to-cell resistance), 245
      ohm/cm; membrane capacitance, 1.46 muF/CM2. The membrane resistance increased
      from 16 to 136 kohm/cm2 during phase 4. The space and time constants showed
      commensurate changes, from 0.95 to 3.2 mm, and from 29 to 269 msec, respectively.
      The input resistance also increased, from 1.1 to 3.8 Mohm.

PMID- 1033293
TI  - Electrophysiological study of coupling between cultured cells of the mouse
      mammary gland in five distinct physiological states.
AB  - Electrical coupling has been observed between cultured cells of the mouse mammary
      gland in five distinct physiological or pathological states. We have employed
      young primary cultures of cells dissociated from the following tissues: normal
      glands from young virgin or midpregnant females, hyperplastic alveolar nodules
      (believed to be precancerous) transplanted in gland-free mammary fat pads, and
      spontaneous mammary adenocarcinomas and their pulmonary metastases. All
      successfully impaled pairs of cells (a total of 97 pairs) were found to be
      ionically coupled. Furthermore, in normal and tumor cell cultures, electrical
      coupling was observed between dome-dome and dome-nondome cell pairs. This study
      correlates with electronmicroscopic studies of fresh normal, hyperplastic, and
      tumor samples, which show the presence of gap junctions in all three.

PMID- 1033294
TI  - Long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa of the rat.
AB  - The long-term effect of shoyu (Japanese soy sauce) on the gastric mucosa was
      assessed in intact rats and in those with a fundusectomy. One hundred female 4
      month-old Wistar rats were divided into 4 groups:intact and operated rats on a
      control diet and intact and operated rats on the same diet saturated with shoyu.
      The animals given shoyu were smaller than the controls; 15 intact rats receiving
      the sauce were healthy at 33 months compared with 7 controls. Only 9 of 50
      operated rats lived 33 months. Breast tumors developed in 10 control rats but in
      none given shoyu. The distribution of other tumors was the same. Two malignant
      neoplasms appeared to originate in the perigastric tissues of operated rats: a
      reticulum cell sarcoma in the shoyu group and a lymphosarcoma in the control
      group. None involved the gastric mucosa. Most of the operated rats (with or
      without shoyu) developed small benign gastric tumors. Mucosal histology was well
      preserved in 22 intact rats on shoyu: In 15 it was normal, in 7 there was mucus
      loss and nuclear changes in the cells of the gastric pits; 2 of the 7 had mild
      gastritis. One intact control showed patchy mucus loss. Shoyu did not appear to
      be a carcinogen in the rat; its prolonged use impaired neither health nor
      longevity. Long-term use was associated with gastric mucus loss and nuclear
      changes in a few rats, occasionally with a mild gastritis.

PMID- 1033295
TI  - Chemical probes of estrogen action: affinity labeling.
AB  - A systemic approach has been taken in the preparation and evaluation of
      photoaffinity labeling agents for the estrogen receptor from rat and lamb uterus.
      Several derivatives of estradiol and the nonsteroidal estrogen, hexestrol,
      containing photoreactive diazocarbonyl or azide functions have been synthesized.
      The receptor binding affinity of these compounds and their capacity to
      photointeract with the estrogen binding site (inactivate) can be assayed
      inderectly by competition assays. Several of the compounds that showed both
      resonably high binding affinities and inactivation efficiencies have been
      prepared in high specific activity, tritium-labeled form. Direct binding
      measurements with these derivatives in unpurified rat uterine receptor
      preparations, show that while these compounds bind to the receptor, they also
      show considerable nonspecific binding to nonreceptor proteins. Irradiation of
      these derivatives in rat uterine cytosol preparations results in incorporation of
      large amounts of radioactivity into protein in a covalent fashion. The amount of
      nonspecific labeling is so large, however, that estrogen site specificity
      (indicated by protection with unlabeled estradiol) cannot be demonstrated. More
      recently, we have used a partially purified receptor preparation from lamb
      uterus. The receptor in this preparation has been disaggregated by mild
      trypsinization and can be electrophoresed in native form. Electrophoretic
      analysis of the proteins in photolabeled preparations show some covalent
      incorporation into the receptor region of the gel with one derivative but not
      with another. The effectiveness of the photoaffinity labeling reagents prepared
      thus far is assessed, and suggestions are made for the design of new, more
      effective reagents.

PMID- 1033296
TI  - Effects of catecholamines on behavior.
AB  - The potential for at least partial reversible transition of aggression- and
      anxiety-type symptomatology suggested searching for a potential biochemical link
      between subcellular mechanisms involved in the execution of aggression and
      anxiety. The effects of norepinephrine combined with dopamine and of epinephrine
      on these two types of behavior were tested. Responses to foot-shock were used to
      test aggression, extinction of avoidance response was used to test anxiety-type
      behavior. The results suggested that one of the possible links between the
      intracerebral processes responsible for execution of aggression- and anxiety-type
      behaviors is transmethylation of norepinephrine and/or dopamine to epinephrine.

PMID- 1033297
TI  - Brown tumor of the maxilla due to secondary hyperparathyroidism.
AB  - The paper describes a patient with brown tumor of the maxilla caused by secondary
      hyperparathyroidism, and gives an account of pathophysiology and management.

PMID- 1033298
TI  - [Clinical and pathological study on the idiopathic cardiomyopathy (On congestive
      cardiomyopathy and its allied disease) (author's transl)].

PMID- 1033299
TI  - [Distribution of 51Cr-labelled endotoxin on tissue and intracellular organella in
      mice].

PMID- 1033300
TI  - [Effects of anesthetics on the organ blood flow. 2. Effects of methoxyflurane on
      cardiac output and blood flow to the renal, superior mesenteric and carotid
      arteries].

PMID- 1033301
TI  - [Simultaneous determination of local anesthetics in the total blood by gas
      chromatography].

PMID- 1033302
TI  - [Observation of power spectra of EEG during anesthesia with fluorinated
      inhalation anesthetics].

PMID- 1033303
TI  - [Effects of simple hypothermia on lipids].

PMID- 1033304
TI  - [Acupuncture in ophthalmic surgery].

PMID- 1033306
TI  - [Anesthesia check system].

PMID- 1033305
TI  - [Myopathic syndrome induced by general anesthesia--a case report].

PMID- 1033307
TI  - [Correlation between neurochemistry and psycho-neurologic diseases].

PMID- 1033308
TI  - [Biochemical studies of schizophrenia].

PMID- 1033309
TI  - [Biochemistry of senile dementia].

PMID- 1033310
TI  - [Biochemistry of Parkinsonism].

PMID- 1033311
TI  - [Congenital heart disease].

PMID- 1033312
TI  - [Wolff-Parkinson-White syndrome--classification and diagnosis of pre-excitation
      syndrome and Lown-Ganong-Levine syndrome].

PMID- 1033313
TI  - [Hyperosmolar non-ketotic diabetic coma--report of 2 cases and studies of 63
      cases in Japanese literature].

PMID- 1033314
TI  - [15-year-old girl with undefined syndrome of non-familial, bilateral calcificatin
      of the basal nuclei, television-induced epilepsy, growth retardation, reduced
      mental capacity and hearing impairment].

PMID- 1033316
TI  - [Surgical management of cerebellar hemangioblastoma].

PMID- 1033315
TI  - [2 families with double albuminemia].

PMID- 1033317
TI  - [Routine kidney function tests].

PMID- 1033318
TI  - [Changes of kidney function with age--from population studies of Kuyama City].

PMID- 1033319
TI  - [Kidney function and biopsy, with special reference to glomerulonephritis].

PMID- 1033320
TI  - [Function of the kidney medulla and controlling factors: intervention by the
      cortical function].

PMID- 1033321
TI  - [Kidney function tests application to the prognosis].

PMID- 1033322
TI  - [Urinary protein analysis and kidney function, with special reference to
      proteinuria in kidney tubular disorders].

PMID- 1033323
TI  - [Kidney function tests and prognosis--applicatin of Markov chains].

PMID- 1033324
TI  - [Papules (1)].

PMID- 1033325
TI  - [Management of National Health Service in England].

PMID- 1033326
TI  - [Experimental studies of vectorcardiographic inductions. Studies with a simple
      model].

PMID- 1033327
TI  - [Changes of body surface potential caused by heterogeneity in conductivity in the
      torso--studies with a torso model].

PMID- 1033329
TI  - [Concepts of normal values].

PMID- 1033328
TI  - [Vectorcardiography and spathol velocity ECG in experimental diffuse
      myocardiopathy].

PMID- 1033330
TI  - [Variation of normal values and multivariate analysis].

PMID- 1033331
TI  - [Biochemical screening].

PMID- 1033332
TI  - [Determination of total proteins and protein fractions].

PMID- 1033333
TI  - [Determination of immunoglobulins].

PMID- 1033334
TI  - [Interpretation of serum colloid reactions].

PMID- 1033335
TI  - [Determination of NPN (BUN)].

PMID- 1033336
TI  - [Determination of ammonium nitrogen and amino nitrogen].

PMID- 1033337
TI  - [Determination of uric acid].

PMID- 1033338
TI  - [Determination of creatine and creatinine].

PMID- 1033339
TI  - [Determination of serum glucose and interpretation of glucose tolerance test].

PMID- 1033340
TI  - [Determination of pyroracemic acid and lactic acid].

PMID- 1033341
TI  - [Determination of serum total lipids and phospholipids].

PMID- 1033342
TI  - [Determination of serum triglycerides].

PMID- 1033343
TI  - [Determination of serum free fatty acid].

PMID- 1033344
TI  - [Determination of serum and urinary ketone bodies].

PMID- 1033345
TI  - [Determination of serum lipoproteins].

PMID- 1033346
TI  - [Determination of serum bilirubin and its significance in internal medicine].

PMID- 1033347
TI  - [Determination of serum bilirubin in pediatrics].

PMID- 1033348
TI  - [Determination of abnormal hemoglobin].

PMID- 1033349
TI  - [Determination of serum iron and iron-binding capacity].

PMID- 1033350
TI  - [Determination of serum copper].

PMID- 1033351
TI  - [Determination of serum magnesium].

PMID- 1033352
TI  - [Determination of serum calcium and inorganic phosphorus].

PMID- 1033353
TI  - [Determination of sodium, potassium and chlorine].

PMID- 1033354
TI  - [Blood gas analysis].

PMID- 1033355
TI  - [Determination of serum progesterone].

PMID- 1033356
TI  - [Determination of urinary gonadotropin].

PMID- 1033357
TI  - [Determination of blood FSH, LH and hCG levels].

PMID- 1033359
TI  - [Determination of serum antidiuretic hormone].

PMID- 1033358
TI  - [Determination of serum GH (growth hormone)].

PMID- 1033360
TI  - [Determination of serum gastrin].

PMID- 1033361
TI  - [Determination of fibrinogen and fibrin degradation products].

PMID- 1033362
TI  - [Determination of GOT and GPT].

PMID- 1033363
TI  - [Determination of LDH and its isoenzymes].

PMID- 1033364
TI  - [Determination of leucine aminopeptidase].

PMID- 1033365
TI  - [Determination of serum trypsin and its inhibitors].

PMID- 1033366
TI  - [Determination of serum cholinesterase].

PMID- 1033367
TI  - [Determination of serum aldolase].

PMID- 1033368
TI  - [Determination of serum alkaline phosphatase and its isoenzymes].

PMID- 1033369
TI  - [Determination of leukocyte alkaline phosphatase].

PMID- 1033370
TI  - [Determination of rheumatoid factor (rheumatoid arthritis test)].

PMID- 1033371
TI  - [Antiglobulin test (Coombs' test)].

PMID- 1033372
TI  - [Determination of ASO (antistreptolysin 0)].

PMID- 1033373
TI  - [Interpretation of TPHA, FTA-ABS and STS reactions].

PMID- 1033374
TI  - [Experience with multiphasic laboratory screening on Tokai University Hospital
      (author's transl)].

PMID- 1033375
TI  - [A prospect for a future of multiphasic screening testing (author's transl)].

PMID- 1033376
TI  - [The effects of the physiological variations on the chemical constituents in
      human body fluids (author's transl)].

PMID- 1033377
TI  - [Reliability of laboratory data from analytical and pathological aspects
      (author's transl)].

PMID- 1033378
TI  - [An approach to individual normal values and ranges in AMHTS (author's transl)].

PMID- 1033379
TI  - [Study on a statistical analysis of the data for biochemical screening (author's
      transl)].

PMID- 1033380
TI  - [Changes in the blood coagulation system during therapeutic defibrination by
      defibrase (author's transl)].

PMID- 1033381
TI  - [Pulmonary function in healthy subjects and its prediction. 3. Spirography in
      adults (author's transl)].

PMID- 1033382
TI  - [Pulmonary function in healthy subjects and its prediction. 4. Subdivisions of
      lung volume in adults (author's transl)].

PMID- 1033383
TI  - [The estimation method for plasminogen content using fibrin plate with urokinase
      (author's transl)].

PMID- 1033384
TI  - [Fatty acid composition of serum lipoproteins in renal diseases (author's
      transl)].

PMID- 1033385
TI  - [Gathrie's method of mass screening for inborn metabolic errors (author's
      transl)].

PMID- 1033386
TI  - [A clinical method with zero time blank (author's transl)].

PMID- 1033387
TI  - [Behaviour of mercury in animals. I Distribution of mercury binding protein in
      the kidney and liver of mice exposed to HgCl2].

PMID- 1033388
TI  - [The analysis of metals contained in water colours and urinary Pb and Cd of
      children who practice painting in a private school (author's transl)].

PMID- 1033389
TI  - Studies on human adaptability to climatic conditions. Report 4. Seasonal
      variations in basal metabolic rate on civilian Japanese and Caucasians in Japan.

PMID- 1033390
TI  - Studies on human adaptability to climatic conditions. Report 5. Seasonal
      variations in serum protein bound iodine on civilian Japanese and Caucasians in
      Japan.

PMID- 1033391
TI  - Studies on human adaptability to climatic conditions. Report 6. Seasonal
      variation in serum FFA on civilian Japanese and Caucasians in Japan.

PMID- 1033392
TI  - [Health effects of long-term tuna diet in cats. I. On the dose-response
      relationship between the amount of tuna consumed and the numerical aberration of
      lymphocyte chromosome (author's transl)].

PMID- 1033393
TI  - [Decrease of gastric secretion in rats orally administered with stannous chloride
      (author's transl)].

PMID- 1033394
TI  - [Studies on closed mines from the stand-point of social medicine. Report I.
      Health hazards among workers and residents at Toroku mine (author's transl)].

PMID- 1033395
TI  - [Physiological aspects of language behavior].

PMID- 1033397
TI  - [Cardiac function].

PMID- 1033396
TI  - [Mechanochemical materials (artificial muscles)].

PMID- 1033398
TI  - [Trend analysis of clinical time series data--prognostic estimation in acute
      myocardial infarct].

PMID- 1033399
TI  - [Digital simulation of the surface isopotential map].

PMID- 1033400
TI  - [Deep body temperature monitoring in cardiac surgery].

PMID- 1033401
TI  - Diffuse interstitial pneumonia and fibrosis: (fibrosing alveolitis).

PMID- 1033402
TI  - [Relapsing polychondritis with dominant respiratory symptoms--an autopsy case].

PMID- 1033403
TI  - [Experimental studies of pulmonary hypertension--correlation between pulmonary
      arterial pressure and histopathological changes of the pulmonary vasculature].

PMID- 1033404
TI  - [Metabolism and effects of vasoactive substance in the lung. 10. Effects of
      calcium antagonist, verapamil, on the smooth muscle of the trachea].

PMID- 1033405
TI  - [Dressler's syndrome, probably due to angina pectoris (author's transl)].

PMID- 1033406
TI  - [Current approach and evaluation of respiratory function tests in screening
      respiratory diseases caused by air pollution].

PMID- 1033407
TI  - [Surgical management of ventricular septal rupture associated with acute
      myocardial infarct with special reference to surgical experiences with 6 cases].

PMID- 1033408
TI  - [Open treatment of chronic empyema, with special reference to the modified
      Floesser method].

PMID- 1033409
TI  - [Primary empyema--study of cases].

PMID- 1033410
TI  - [Evaluation of decortication in primary tuberculous empyema--studies based on the
      changes of pulmonary function before and after the operation].

PMID- 1033411
TI  - [Surgical management of atypical mycobacterial pulmonary disease and its
      evaluation].

PMID- 1033412
TI  - [Device for retaining a tube in the pulmonary artery and left atrium following
      open heart surgery].

PMID- 1033413
TI  - [Role of the contraction and size of the right ventricular free wall in
      ventricular function].

PMID- 1033414
TI  - [2 cases of tetralogy of Fallot associated with a unilateral defect of the
      pulmonary artery].

PMID- 1033415
TI  - [Problems of superior vena cava syndrome].

PMID- 1033416
TI  - [Mediastinal neoplasm associated with thrombocytopenic purpura and pure red cell
      anemia].

PMID- 1033417
TI  - [Successful management of neurilemmoma originating at the left vagus nerve of the
      mid-superior mediastinum].

PMID- 1033418
TI  - [Diagnosis and surgical management of corrected transposition of great vessels].

PMID- 1033419
TI  - [Successful management of postinfarctional ventricular septal rupture associated
      with left ventricular aneurysm and severe pulmonary hypertension].

PMID- 1033420
TI  - [2 cases of accessory cardiac bronchus (Huzly) with hemoptysis as a major
      symptom].

PMID- 1033421
TI  - [Removal of a foreign object (gauze) following thoracic surgery].

PMID- 1033422
TI  - [Successful management and preoperative diagnosis of thymic cyst].

PMID- 1033423
TI  - [Agenesis and ectoplasia of the right lung communicating with the esophagus].

PMID- 1033424
TI  - [Autoblood pumping therapy for cerebral embolism following heart valve
      replacement].

PMID- 1033425
TI  - [Electron microscopic studies of the etiology of kidney calculi].

PMID- 1033426
TI  - [Organic impotence].

PMID- 1033427
TI  - [Functional impotence].

PMID- 1033428
TI  - [Selected problems in the prevention of retinal detachment].

PMID- 1033429
TI  - [Diabetic retinopathy treated with photocoagulation].

PMID- 1033430
TI  - [Macular cystoid degeneration treated with laser radiation].

PMID- 1033431
TI  - [Therapeutic management of retinoschisis].

PMID- 1033432
TI  - [Argon laser photocoagulation in experimental vitreous body hemorrhage in
      rabbits].

PMID- 1033433
TI  - [Argon laser photocoagulation of changes in the vitreous body].

PMID- 1033434
TI  - [Preliminary experiences in the treatment of retinal diseases with argon laser].

PMID- 1033435
TI  - Tissue factor in cultured cells: metabolic control.
AB  - Tissue factor content of WISH amnion cells in spinner culture increases 3- to 10
      fold within 12 hours after subculture, then declines to a basal level within 30
      to 50 hours. Maximal development of activity requires fresh serum and fresh
      medium. When added at the time of subculture, actinomycin D and cycloheximide
      completely inhibit development of coagulant activity; when added several hours
      after transfer, these inhibitors suppress the development but do not affect the
      disappearance of activity. Of the oxidative phosphorylation inhibitors tested,
      dinitrophenol had no effect whereas carbonyl cyanide m-chlorophenylhydrazone
      inhibited the activity increase but did not alter the decline. The kinetics of
      development and decay are similar over a pH range of 6.7 to 7.6 and with fetal
      calf serum concentration between 5 and 30 per cent. At pH 6.7 or in 30 per cent
      fetal calf serum, cell division did not occur. 3H-leucine and 35SO4=
      incorporation into the cell surface coat did not change appreciably during the
      burst of coagulant activity nor did the levels of naphthylamidase or alkaline
      phosphatase; 3H-thymidine incorporation reached a peak within 2 hours of the
      tissue factor maximum.

PMID- 1033436
TI  - A field survey of pistachio (Pistacia vera) nut production and storage in Turkey
      with particular reference to aflatoxin contamination.

PMID- 1033437
TI  - Improved separation of the major water-soluble proteins of soya meal by a single
      step chromatographic procedure.

PMID- 1033438
TI  - The action of cytochalasin A on the in vitro polymerization of brain tubulin and
      muscle G-actin.
AB  - The presence of cytochalasin A inhibits the self-assembly of beef brain tubulin
      and rabbit muscle G-actin in vitro and also decreases the colchicine binding of
      tubulin. Prior reaction of cytochalasin A with 2-mercaptoethanol destroys its
      inhibitory effects. It is shown that cytochalasin A exerts its actions by
      reacting with sulfhydryl groups, possibly causing irreversible structural changes
      in the proteins. Cytochalasin B does not affect the tubulin assembly reaction.

PMID- 1033439
TI  - Hemangiosarcoma of the spleen: report of a case and review of previously reported
      cases.
AB  - Splenic hamangiosarcomas are rare tumors, usually discovered at autopsy. In a few
      instances the diagnosis was made premortem, at the time of splenectomy for
      spontaneous rupture. The tumors usually present with abdominal pain, left upper
      guadrant mass and tenderness, and occasionally with a microangiopathic type of
      anemia. The histogenesis of the tumor is in dispute. Some authors feel that they
      are degenerations of hemangiomas. Others feel that they arise de novo in the
      spleen. There is not proven association of thorotrast administration or vinyl
      chloride exposure to the development of hemangiosarcomas in the spleen. The
      prognosis of the tumor is uniformly poor and most of the patients surviving
      laparotomy have followed a uniformly fatal clinical course. In a few cases
      treated with chemotherapy there has been no evidence of clinical benefit. The
      case report in this article presented with essentially all the features
      enumerated above.

PMID- 1033440
TI  - On rate-sensitive chemoreceptor systems and the origin of the immune response.

PMID- 1033441
TI  - Tricuspid regurgitation. A comparison of nonoperative management, tricuspid
      annuloplasty, and tricuspid valve replacement.
AB  - The best means of managing tricuspid regurgitation associated with mitral or
      mitral and aortic valve disease is still to be determined. During the period 1972
      to 1974, we treated 76 patients who had tricuspid regurgitation along with
      associated valvular dysfunction. Patients with mold regurgitation were treated
      conservatively, those with moderate regurgation underwent annuloplasty, and those
      with severe regurgitation had tricuspid valve replacement. We found the results
      to be less satisfactory in the group treated by annuloplasty than in the other
      two groups. We still manage conservatively those patients with mild
      regurgitation, but we believe it appropriate to replace the valve in an
      increasing number of subjects who have tricuspid regurgitation of moderate
      severity.

PMID- 1033442
TI  - Transfer of polycyclic hydrocarbons from diet to milk in rats, rabbits and sheep.

PMID- 1033443
TI  - Leukemia cell lysis by sulphydryl reagents and thiols.

PMID- 1033444
TI  - Aspects of opiate dependence in the myenteric plexus of the guinea-pig.

PMID- 1033445
TI  - Prolyl-leucyl-glycinamide (PLG) facilitates morphine dependence.

PMID- 1033446
TI  - The effect of dimethylaminoethanol (deanol) on amphetamine-induced stereotyped
      behavior (AISB).

PMID- 1033447
TI  - Strain-dependent differences in responses to chronic administration of morphine:
      lack of relationship to brain catecholamine levels in mice.

PMID- 1033448
TI  - Fatty acid variability of plasma lipids and cholesteryl esters in adult male
      twins and their brothers.
AB  - Variation in the fatty acid composition of fasting plasma lipids and of
      cholesteryl esters was studied in 69 sets of adult male twins and 25 of their
      brothers. Genetic variances were estimated using the twin model. In general,
      monozygotic (MZ) twins were characterized by the smallest within-pair variance,
      and brothers of twins by the largest. Variation within dizygotic pairs fell
      imtermediate to that of MZ twins and brothers. The present study did not reveal
      consistent significant (P greater than 0.05) genetic variation in plasma fatty
      acids from total plasma lipids or cholesteryl esters.

PMID- 1033449
TI  - Retarding effects of DNA on the autoxidation of liposomal suspensions.
AB  - Deoxyribonucleic acid (DNA) is associated with the cell membrane of prokaryotes
      and the inner nuclear membrane of eukaryotes. The unsaturated fatty acids of
      phospholipids, which constitute the bilaminar structure of membranes, undergo
      autoxidation in the presence of O2. Calf thymus DNA was incuabted with methyl
      archidonate-enriched phosphatidyl choline liposomes in order to study the effect
      of DNA upon the oxidation of phospholipids while present in their natural in vivo
      bilayer configuration. DNA retarded the rate of lipid oxidation as monitored by
      both diene conjugation and the TBA test, but it did not alter the induction
      period. These results suggest that DNA is scavenging free radicals produced
      within the phospholipid bilayer.

PMID- 1033450
TI  - Ciguatera.

PMID- 1033451
TI  - [Urethritis syndrome and atypical germ flora of the exterior female genitalia
      (author's transl)].
AB  - A positive microbiological evidence could be obtained 54 times from the smear of
      the exterior genitals of 80 women suffering from complaints that were caused by
      urethritis, criteria of the examinations being sterile catheter specimen,
      negative cystoscopical findings, and missing indications to anatomical changes in
      the urethral region. Cytological examinations of these cases with regard to the
      vaginal epithelium had the following results:Group I:6 times; group II: 37 times;
      group IIW:8 times; group IIId: once; group IVa:twice. The cytological tests were
      carried out according to the method of papanicolaou as modified by Soost.
      Furthermore, we could state the following degrees of purity: Degree I: 8 times;
      degree II:16 times; degree III: 30 times. The cytological examinations of the
      urethral epithelium demonstrated, in 52 cases, an increased appearance of "nude"
      completely exposed epithelial cell nuclei--a fact corresponding to a degenerative
      autolysis (according to Wied). In the 26 women with missing atypical germ flora
      within the region of the exterior genitals, exclusively groups I (according to
      Papanicolaou and Soost) and degrees of purity I were stated. These persons also
      demonstrated remarkably grave psychical disturbances, especially in the intimate
      regions. In the cases of positive microbiological evidence, the following
      measures have proved satisfactory: Vaginal hygienization combined with a directly
      aimed antibacterial therapy, and the prescription of preparations containing
      lactic acid. A transitory discontinuation of contraceptives is being discussed.
      Our examination results are emphasizing the necessity of an analysis of the germ
      flora in cases of complaints arising from urethritis. Also psychical disturbances
      must be taken into consideration in cases of missing urological and
      gynaecological criteria of evidence.

PMID- 1033452
TI  - [Zinc metabolism. Note VI. Distribution of zinc in various protein fractions of
      powdered milk. Comparison with human and cow's milk].

PMID- 1033453
TI  - [Newborn heart decompensation due to rhythm disorders. Apropos of a case].

PMID- 1033454
TI  - [Prevention and treatment of anoxic damage in the fetus and newborn].

PMID- 1033455
TI  - The changing patterns of perinatal mortality at a suburban community hospital.

PMID- 1033456
TI  - Mechanism of action of methotrexate. IV. Free intracellular methotrexate required
      to suppress dihydrofolate reduction to tetrahydrofolate by Ehrlich ascites tumor
      cells in vitro.

PMID- 1033457
TI  - [Extrahepatic stenosis of the portal vein after infection or catheterization of
      the umbilical vein during the neonatal period (author's transl)].
AB  - 147 children with high risk of developing a prehepatic portal vein obstruction
      were reexamined. The children had survived during their neonatal period:--Serious
      umbilical infection and sepsis (n=33)--Multiple exchange transfusion (n=55)--Long
      term umbilical vein catheter treatment for at least 24 hrs (n=59). The
      reexamination at the age of 2--4 years revealed one case of total occlusion of
      the vena lienalis with partial obstruction of the vena portae in a child with
      former umbilical sepsis. Even though the etiologic relation of neonatal umbilical
      disorders and prehepatic portal obstruction is evident, the risk for the
      individual case seems to be low.

PMID- 1033458
TI  - Colonization of soybeans by species of Fusarium.

PMID- 1033459
TI  - The systematics of the genus Strongwellsea (Zygomycetes: Entomophthorales).

PMID- 1033460
TI  - Deightoniella argemonensis, a new fungus on Mexican pricklepoppy, associated with
      Cercosporidium guanicense.

PMID- 1033461
TI  - The quandary of quality assessment.
AB  - Inevitably, quality assurance reflects the context of which it is a part (e.g.,
      underuse or overuse of services is partly a function of their availability and
      financing). Thus, it can promote change or rationalize lack of it, save money or
      cost money. Given the current state of the art, it is imperative to develop
      quality assurance on an evolutionary path while options are kept open and focus
      is clearly on outcomes. Also, quality assessment must be conceptualized as a
      behavioral tool, not a policing mechanism; its scope must be broadened to include
      the total episode of illness, taking into account life-style and environmental
      factors, with criteria developed and applied as close to the point of patient
      care as possible, within broad  guidelines; it is essential to build on in-place
      capacities -- e.g., carrier data -- rather than to create new overlapping
      systems. Finally, the management setting within which quality assurance
      functions, in both the public and private sectors, must be improved.

PMID- 1033462
TI  - First European report of swine infection by Microsporum nanum.
AB  - The first European case of swine infection by Microsporum nanum is reported. The
      infected pig came from a farm in the Emilia-Romagna region of Italy. European
      records of human and lower animal infections by this fungus and soil isolation
      records are discussed.

PMID- 1033463
TI  - The action of trypsin and chymotrypsin on the reserve proteins of some leguminous
      seeds.
AB  - The action of trypsin on the reserve proteins of the leguminous seeds belonging
      to Vicieae and Phaseoleae tribes was investicated. The hydrolysis of11S and 7S
      proteins of Vicieae proceeds relatively fast and some of the proteins are
      hydrolyzed practically completely. The hydrolysis of most of the investigated
      reserve proteins of the Phaseoleae tribe proceeds much slower, while that of 7S
      proteins of four Phaseolus species of American origin stops after the cleavage of
      only 10-20% of peptide bonds capable of reacting. Analogous results were obtained
      studying the action of chymotrypsin on a more restricted number of proteins. Both
      trypsin and chymotrypsin hydrolyze the same parts of Ph. vulgaris 7S protein,
      splitting off peptides which can be separated on a Sephadex G-50 column. The
      nonhydrolyzable high molecular weight core has a slightly smaller sedimentation
      coefficient and a higher elelctrophoretic mobility than the native protein and is
      able to dimerize at high ionic strength. Urea does not alter the hydrolyzability
      of the core butt the latter is partially hydrolyzed after the action of urea or
      guanidine hydrocholoride in the presence of mercaptoethanol.

PMID- 1033464
TI  - X-ray induced mutations, DNA and target theory.

PMID- 1033466
TI  - [Ethics, atmosphere and deontology].

PMID- 1033465
TI  - [A case of frontal arteriovenous malformation with optochiasmatic arachnoiditis
      as an initial symptoms (author's transl)].
AB  - A surgically cured case of chronic optochiasmal arachnoiditis presumably caused
      by concomitant right frontal arteriovenous malformation (AVM) is reported. When a
      12-year-old boy, suffering from blurred vision for about 1 month, visited the
      Ophthalmological Clinic of Hirosaki University Hospital, only a chiasmal lesion
      was suspected because neuro-ophthalmological examination revealed no more than
      ophthalmic signs, such as bilateral diminution of vision (Vd, Vs = 0.2),
      concentric narrowing of visual fields and slight bilateral papilledema. The
      patient was referred to the Neurosurgical clinic for further examination. Left
      carotid angiograms showed no abnormalities but, thereafter the brain scintigram
      revealed an abnormal hot area in the right frontoparietal region. A right carotid
      angiography demonstreated an AVM in the posterior part of the right frontal lobe.
      This was fed through the right anterior and middle cerebral arteries and drained
      into the superior sagittal sinus through meandering dilated cortical vein.

PMID- 1033467
TI  - [Involuntary movement (author's transl)].

PMID- 1033468
TI  - [Surgical treatment of the orbital blow-out fracture (author's transl)].

PMID- 1033469
TI  - [Akinetic mutism (author's transl)].

PMID- 1033470
TI  - [Meningioma in the aged--on its differential diagnosis (author's transl)].
AB  - Despite vast improvement in diagnostic techniques in neurosurgery during the past
      few decades, there still remain a significant number of intracranial tumors in
      geriatric age group, which are not recognized in the early course of the disease
      or during life. We are now focusing on the diagnostic problems of meningiomas in
      the geriatric age group and stressing the significant value of brain scanning in
      the differential diagnosis of brain tumors from cerebral vascular disease or
      other conditions. During about 10-year period, a total of 36 intracranial tumours
      in cases over 60 year old have been studied. Sixteen of these tumors are
      meningiomas and form the basis of this report. The age of these cases was between
      60 and 83 years with average of 70.5. There were two males and 14 females. As to
      the location, four were parsagittal and falx meningiomas, three were at
      tuberculum sellae, two were at sphenoidal ridge, one was at tentorium in
      location. Twelve cases were erroniously diagnosed and confusion with
      cerebrovascular disease was most common. We analysed the onset and the
      progression of symptoms of our 16 cases, and picked up and stressed the four
      peculiarities of geriatric meningiomas. The first one is that the onset of
      symptoms is very sudden, almost precipitate, and the subsequent clinical course
      may be so rapidly progressive. The six patients in our cases were included in
      this group. A case among those was verified to be complicated with intratumoral
      hemorrhage, and another one with a subdural hematoma. The vast contrast to the
      first group is the second peculiarity. The meningioma especially in the geriatric
      age group may frequently unfold a clinical picture, which by its very insidious
      onset and slow development may be even unrecognized during life. The third is
      that patients developed dementia, at the onset in two cases and in any course of
      this disease in six. All too frequently in these instances the tumor has been
      overlooked and wrongly diagnosed as a senile dementia or psychosis. The fourth is
      that the meningioma developed with intermittent, recurrent and streotyped
      cerebral symptoms including epilepsy. We presented a case with intermittent
      aphasia due to a convexity meningioma on the dominant side. In almost all cases,
      manifestation of increased intracranial pressure was absent or not significant.
      There was found a papilledema in only one case, and cerebrospinal fluid revealed
      a normal pressure in six out of eight cases in which lumbar puncture was
      performed. It was proved that brain scanning was one of the most useful adjuncts
      in the diagnosis of brain tumor in the aged even in serious conditions. Changing
      brain scan patterns in association with clinical course is a useful diagnostic
      guide in differentiating tumors from cerebrovascular accidents. The serial scan
      density change is more meaningful if the clinical course is considered. Scanning
      should be done as soon as possible when the brain tumor is suspected and should
      be rescanned if necessary.

PMID- 1033471
TI  - [Massive epistaxis from intracranial extradural aneurysm of the internal carotid
      artery associated with head injury (author's transl)].
AB  - Severe epistaxis following head injury occur from damage to the anterior
      ethmoidal or sphenopalatine arteries. However, the more massive, life-threatening
      posttraumatic epistaxis is that arising from ruptured aneurysm, arteriovenous
      fistula, or tear of the intracranial extradural portion of the internal carotid
      artery. The authors had opportunities to treat successfully 3 cases of massive
      delayed epistaxis from the aneurysm of this site following closed head injury.
      Case 1. A 23-year-old man was injured in a motorcycle accident on April 19, 1968
      and taken to an emergency hospital, where the findings were semicomatose state,
      profuse bleeding from the left nostril and oral cavity, and laceration above the
      left eye associated with fracture of the left sphenoid. Since regaining
      consciousness he was blind in the left. Slight localized protrusion of the
      cavernous portion of the left internal carotid was shown by angiography, which
      was performed on the next day (Fig. 1). Three days later, he was transfered to
      Toyokogyo Hospital. On April 29, he had sudden severe epistaxis. The nasal
      bleeding recurred massively 6 times over 2 months, requiring the replacement of
      more than 8000 cc of blood. Sixty days after the trauma, carotid angiography
      demonstrated an large aneurysm arising from the left internal carotid (Fig. 2).
      The authors were consulted on this occasion. Intra- and extracranial trapping of
      the internal carotid artery associated with muscle embolization (Jaeger's
      operation) was performed (Fig. 3). Postoperative course was uneventful except
      occurrence of temporary diabetes insipidus. Case 2. This 59-year-old man was
      admitted to our clinic on November 7, 1970, Because of posttraumatic recurrent
      massive epistaxis. Thirty-seven days before admisstion, he was hitted by a car
      and lost consciousness. Profuse nasal bleeding occurred immediately after the
      accident. Despite skin lacereation above the right eye, visual acuity was not
      distrubed and no fracture line was found. Two weeks after the injury, he had
      sudden massive bleeding from the right nostril. The epistaxis recurred 5 times
      over 3 weeks. Carotid angiography revealed an aneurysm arising from the right
      internal carotid (Fig. 4). The internal carotid was gradually occluded at the
      cervical level without any neurological complication. Case 3. A 33-year-old man
      was referred to our department on October 7, 1974, complaining of recurrent
      profuse bleeding from the oral cavity. About 2 months prior to admission, he fell
      from the fourth floor on the street and became comatose. Several fracture lines
      of the frontal bones were found on skull film. Thirty-six days after the
      accident, sudden severe epistaxis occurred. Massive bleeding from the oral cavity
      repeated every 7 to 10 days. Visual acuity was lost within 10 weeks. III and VI
      cranial nerves palsy was found on the both sides. Carotid angiography
      demonstrated a small aneurysm of the left internal carotid (Fig. 5). Occlusion of
      the internal carotid at the cervical level stopped bleeding without further
      neurological deficit...

PMID- 1033472
TI  - [Bilateral traumatic abducens nerve palsy without skull fracture or intracranial
      hematoma-a report of 3 cases and consideration of the mechanism of injury
      (author's transl)].
AB  - Three cases of bilateral traumatic abducens nerve palsy were presented and the
      mechanism of damage to the abducens nerve was discussed in relation to the
      analysis of traumatic force at the time of impact and topographical anatomy of
      the abducens nerve in detail. Case 1. A 70 year old man sustained a traffic
      accident with one hour loss of consciousness. Physical examination revealed a
      contused area on the medial side of his right forehead. Neurological examination
      revealed bilateral abducens nerve palsy (Fig. 1). There were no ther cranial
      nerve abnormalities. Roentgenograms of the skull, including views of the base and
      orbit showed no fracture. At follow up examination 12 months later, bilateral
      Duane's retraction syndrome could be noticed with slight increase in size of the
      pupil on each side of lateral gaze (Fig. 2). Case 2. A 32 year old women
      sustained a traffic accident with 31 days of loss of consciousness. At the time
      of admission, bilateral abducens nerve palsy and slight left hemiparesis were
      noticed in semicomatose condition. Right carotid angiogtam showed no evidence of
      intracranial hematoma. One month later, the right eye began to abduct and 2
      months later, the left eye began to abduct. Three months after the injury,
      bilateral abducens nerve palsy could no longer be demonstrated. No retraction
      syndrome was observed during this period. Case 3. A 3 year old boy sustained a
      traffic accident with 32 days of loss of consciousness. At the time of admission,
      neurological examination showed bilateral abducens palsy and left sided
      decerebrate posture in comatose condition. At the time of discharge 3 months
      after admission, bilateral abducens palsy, right hemiataxia, left spastic
      hemiparesis and scanning speach were noticed. Three months later, right eye began
      to abduct and 4 months later, the left eye began to abduct. At follow up
      examination 6 months later, there was no evidence of abducens nerve palsy.
      Topographical details of anatomy of the abducens nerve are shown in Fig. 3, 4. It
      is greatly speculated that both abducens nerves are streched by the lineal
      accerelated force on mid sagittal plane at the time of impact, then the apex of
      petrous pyramid acts as the fulculum, so that the abducens nerves are compressed,
      contused and streched at this point (Fig. 5-a). The authors pointed out that the
      abducens nerve are impossible to be damaged at the petroclinoid ligament
      (Gruber's lig.) by the upward movement of the brainstem, because the abducens
      nerve is fixed downward below this ligament by the dura and apex of the petrous
      pyramid (Fig. 4-b, c). One case showed bilateral acquired retraction syndrome
      with slight increase in size of the pupil on each side of lateral gaze, the fact
      greatly suggesting that the sympathetic nerve have intimate relationship to the
      miss direction during the recovery stage of abducens nerve palsy.

PMID- 1033473
TI  - [The antero-posterior diameter of the cervical spinal canal in cervical
      spondylosis. (Part 2) (author's transl)].
AB  - 1. The antero-posterior diameter (APD) of the cervical spinal canals in 96 cases
      of cervical spondylosis with radiculopathy and radiculomyelopathy was measured
      for each vertebra by the method of Burrows, and the thecoperiosteal diameter
      (TPD) of the cervical spinal canals in the same cases was measured from
      myelograms by the method of Symon. 2. The APD in patients with myelopathy or
      positive Queckentedt's test was found to be significantly smaller than those of
      without them. The upper limit of APD at C4  to C6 vertebrae in patients with
      myelopathy or positive Queckenstedt's test was 15 mm, while the lower limit of
      APD in patients with radiculopathy or negative Queckenstedt's test was 13 mm. As
      based on these findings, the following conclusions were drawn: When the APD is
      smaller than 15 mm, there is always a chance to develop spondylotic myelopathy or
      spinal subarachnoid block though not absolute, but if the APD is smaller than 12
      mm, the patient will have myelopathy and spinal subarachnoid block absolutely
      without exception. 3. The TPD in patients with myelopathy or positive
      Queckenstedt's test was also found to be more significantly smaller than those of
      without them. It could be seen that the smaller the TPD, the more chance to
      develop myelopathy and also spinal subarachnoid block. The upper limit of the TPD
      in myelopathy was 11 mm, and that in spinal arachnoid block was 10 mm. The
      smallest value in radiculopathy was 9 mm, so that it was suggested that a case
      which has the value smaller than 8 mm might develop myelopathy. 4. The hight of
      the inter-body spurs was measured from lateral myelograms in individual case. The
      value in case with myelopathy and positive Queckenstedt's test was much larger
      than that of radiculopathy or negative Queckenstedt's test. The lower limit of
      the hight of the inter-body spurs in case with myelopathy and spinal subarachnoid
      block was 3 mm.

PMID- 1033474
TI  - [A case of suprasellar tumor associated with so-called atypical angina pectoris].
AB  - A case of suprasellar tumor associated with so-called atypical angina pectoris
      was reported. A 58-year-old man was admitted to our hospital on Feb. 2, 1973,
      because of headache, disturbance of visual field and the attack of chest pain. He
      had been suffering from disturbance of visual field for about 3 years and the
      attack of chest pain for about 4 months prior to admission. Neurological findings
      on admission were bitemporal hemianopia, decreased visual acuity and atrophy of
      the optic disc. Bilateral carotid angiography showed upward  displacement of A1
      portion of the anterior cerebral artery. Pneumoencephalography demonstrated
      defect of the anterior part of the third ventricle. Laboratory examination showed
      hypopituitalism. On March 26, 1973, Right frontal craniotomy was performed under
      the diagnosis of suprasellar tumor. The walnut-sized tumor was detected in the
      suprasellar region and removed totally. Histological examination showed dermoid
      cyst. With regard to the attack of chest pain, the selective coronary angiography
      was performed. But organic change was not detected and Master's two step test did
      not  induce any pathological finding in EEG. So we made a diagnosis of so-called
      atypical angina pectoris. There are many arguments about pathogenesis of so
      called atypical angina pectoris. There is no organic change of the heart of
      attention now. Recently it is said that so-called atypical angina pectoris is
      closely connected with paradoxical sleep. We recognized dysunction of the
      autonomic nervous system through various examinations. The hypothalamus was
      displaced upward by a suprasellar tumor in this case. After removal of the
      suprasellar tumor, the frequency of the attack of chest pain was decreased. The
      atypical angina pectoris in the presented case may be considered to consequence
      of distrubance of the hypothalamic function.

PMID- 1033475
TI  - [Cerebrovascular moyamoya disease associated with aneurysm at the peripheral
      portion of the posterior chorioidal artery (author's transl)].
AB  - Three adult cases of cerebrovascular Moyamoya disease associated with aneurysmal
      shadow at the peripheral portion of the posterior choriodial artery are reported.
      According to the follow-up study of carotid angiograms, this aneurysmal shadow is
      considered to be a pseudo-aneurysm, which indicates a bleeding point in the brain
      tissue. It has generally been thought that the mechanism of the occurrence of the
      symptom in adult patient with cerebrovascular Moyamoya disease is due to rupture
      of vessels in the subarachnoid space on the brain surface. But from our
      experience, it is suggested that there should be another mechanism, beginning
      with rupture of vessels in the brain tissue.

PMID- 1033476
TI  - [Complications resulting from ventriculo-peritoneal shunt: an anticipatory
      comment-case report (author's transl)].
AB  - Case is 23 year-old man, Who was admitted to the University Hospital with a
      diagnosis of acoustic neurinoma as a manifestation of von Recklinghausen's
      disease. V-P shunt was performed because of the increased intracranial pressure
      and post-operative course was complicated by repeated bout of meningitis.
      Otherwise, postoperative course was uneventful till about 7 month after placement
      of V-P shunt when the proximal end of the shunt tube perforated into the lumen of
      the intestine and about 30 cm length of shunt tube emerged from anus.
      Subsequently the patient developed meningitis. Nowadays, the tendency was noted
      that ventriculo-peritoneal shunt is more frequently performed than
      ventriculoauricular shunt and so increased incidences of complications
      attributable to the position of the tip of the shunt tube in theperitoneal cavity
      is naturally anticipated. In this report, we discussed the mechanism of
      development of intestinal perforation, its prophylactic measures and the earty
      diagnosis. Number one factor which is attributed to the cause of intestinal
      perforation is a fact that any intra-peritoneal foreign body is potentially able
      to cause intestinal perforation. The second factor is the sharp tip of the
      peritoneal shunt tlbe which more easily cause intestinal perforation than
      otherwise. The third factor is the constant pressure at the same location of the
      intestinal wall over a long period of time which is applied by a peritoneal tip,
      which is considered to cause necrosis of the intestinal wall. The fourth factor
      is relatively poor general condition of the patient and secondary decrease in
      resistance of the intestinal wall against the foreign body. We therefore
      postulate for the prophylaxis and early diagnosis that we should often check the
      position of the tip of the shunt tube end should performed the radiological
      evaluation at the first sight of peritoneal irritation sign. The architecture and
      the location of the tip of the tube, the length and material of the tube seem to
      have intimate relation to the prophylaxis against intestinal perforation and
      these factors have to be evaluated in the future.

PMID- 1033477
TI  - [A case with the combination of cerebral aneurysm and cerebral arteriovenous
      malformation originated from same artery in the same site (author's transl)].
AB  - Several cases associated with cerebral aneurysm and arteriovenous malformation
      have been reported in literature but such case of association with these two
      kinds of cerebral vascular lesion originated from the same artery in the same
      site is quite rare. The authors reported a case of coexistence of cerebral
      aneurysm and cerebral arteriovenous malformation in the parietal area and both of
      these vascular lesion were located closely and were fed by the angular artery. A
      8 year-old girl was warded on March 28, 1974 with a history of attack of headache
      and vomitting before lapsing into semicoma on March 23, 1974. She regained
      consiousness 5 days later but showed speech disturbance. Subarachnoid hemorrahge
      was proved by her home doctor immediately after the episode. On examination,
      motor and sensory impairment was negative. Nominal aphasia and agonosia were
      noted. Four-vessel angiography proved cerebral aneurysm accompanying with
      arteriovenous malformation-like shadow in the left parietal area. A relative
      large drainage vein from the above mentioned vascular lesions drained into the
      superior sagittal sinus.

PMID- 1033478
TI  - Correlation between catalepsy and dopamine decrease in the rat striatum induced
      by neuroleptics.

PMID- 1033479
TI  - Sacral agenesis. Neurologic and neuropathologic features.
AB  - The neurologic deficits in sacral agenesis involve motor function much more than
      sensory function, in a lumbosacral distribution; autonomic involvement, with
      neurogenic bladder, is variable. Relative sensory sparing may be due to the
      derivation of sensory nerves from neural cre, t tissue, which is uninvolved. An
      occult sacral meningomyelocele with ectopic neural tissue was found at necropsy
      in one of our patients. Primary amyoplasia may account for small but
      histologically normal muscles derived from the same somites as the aplastic
      vertebrae.

PMID- 1033480
TI  - Dialysis encephalopathy: a possible seizure disorder.
AB  - Dialysis encephalopathy is a progressive, fatal condition that occurs in patients
      receiving hemodialysis. It is characterized by abnormalities in speech, myoclonic
      jerks, and striking changes on the electroencephalogram. We observed dramatic
      reversal of the clinical symptoms and electroencephalographic abnormalities in
      four patients with this syndrome who were treated with diazepam. In this paper we
      propose that in dialysis encephalopathy, some of the symptoms and the
      electroencephalographic changes represent a form of seizure disorder.

PMID- 1033481
TI  - Anosognosia for hemiplegia: somatosensory evoked potential studies.
AB  - Somatosensory evoked potential studies in nine patients with anosognosia for left
      hemiplegia and in one patient with anosognosia for right hemiplegia revealed an
      absence of response over either hemisphere on stimulation of the median nerve on
      the hemiplegic side. This apparent lack of cortical processing may underlie the
      impaired awareness of the hemiplegic side, manifested as anosognosia.

PMID- 1033482
TI  - Neurophysiologic changes in hemiplegia. Possible explanation for the initial
      disparity between muscle tone and tendon reflexes.
AB  - In an attempt to clarify the neurophysiologic changes that may follow a cerebral
      lesion in man, we have studied patients with recent and with long-standing
      hemiplegia from cerebral infarction. In patients with recent cerebral lesions,
      inhibition of the monosynaptic reflex by vibration is enhanced. In patients with
      long-standing cerebral lesions, this inhibitory mechanism is less effective and a
      comparison of the electrically and mechanically induced monosynaptic reflexes
      suggests that fusimotor drive may be increased. Related clinical findings are
      reduced muscle "tone" immediately after the lesion and increased muscle "tone"
      and exaggerated tendon jerks in patients with long-standing hemiplegia.

PMID- 1033483
TI  - On the movement of fluid through the brain of hydrocephalic cats.
AB  - The effects of changes in serum osmolality on the volume flow of fluid into the
      cerebral ventricles and on brain water content was examined in cats with kaolin
      induced hydrocephalus. Slopes of the regression lines relating volume flow and
      serum osmolality for both normal and hydrocephalic cats are the same. The
      constant difference in flow rates between the two lines, 7 mul per minute, is
      probably due to impaired choroid plexuow rates between the two lines, 7 mul per
      minute, is probably due to impaired choroid plexus function of the hydrocephalic
      cats. The osmotic pressure gradient that causes the flow of fluid is therefore
      probably between blood and brain. Under these conditions changes in brain water
      content of hydrocephalic cats were smaller than in normals and can be related to
      the edema present in this disorder. Despite the inflammatory response to kaolin,
      the blood-brain barrier remains intact. From the calculated filtration
      coefficient, it can be inferred that the flow of water from serum through brain
      and into cerebrospinal fluid is limited by the resistance of fluid flow through
      the brain.

PMID- 1033484
TI  - Efference copy in the control of movement.
AB  - On a two-choice tracking test of normal subjects, numerous false moves were
      induced when the directional relation between movement of the hand and the
      response marker was changed. The mean error-correction times were not
      consistently less than simple reaction times. When the center of the display was
      screened to eliminate visual feedback, numerous moves were reversed before the
      marker was visible. The probability of reversing an error was much greater than
      that of reversing a correct move. The findings are best explained in terms of a
      central mechanism that uses efference copy to amend errors of movement.

PMID- 1033485
TI  - Brain serotonin concentration and crude synaptosomal uptake in mice with the
      Chediak-Higashi syndrome.
AB  - The Chediak-Higashi syndrome is characterized by a serotonin platelet defect and
      neuronal dysfunction. Whole blood serotonin concentration, serotonin brain
      concentration, and synaptosomal uptake of serotonin were determined in mice with
      the syndrome. While brain serotonin uptake in the affected mice was not
      significantly different from that in nonaffected mice, whole blood serotonin
      concentration was markedly reduced. These data suggest that in human neuropathies
      with platelet serotonin defect, a parallel neuronal serotonin disorder may not be
      assumed.

PMID- 1033486
TI  - Femoral neuropathy during anticoagulant therapy.
AB  - Ten cases of acute femoral neuropathy complicating anticoagulant therapy were
      followed over periods of 1 to 5 years. Most patients had either sensory or motor
      residual symptoms, but the two patients who had early surgical intervention made
      rapid recoveries. The danger of parenteral injections or minor trauma to the
      abdomen, buttocks, or thighs in patients receiving anticoagulant therapy is
      emphasized.

PMID- 1033487
TI  - Bilateral altitudinal anopia caused by infarction of the calcarine cortex.
AB  - The patient reported here had a bilateral inferior altitudinal hemianopia from
      lesions of the calcarine (striate) cortex of the occipital lobes. The only
      significant pathologic findings were bilateral calcarine artery occlusive
      disease, with infarcts of the striate cortex on both sides. The ages of the
      infarcts appeared compatible with the clinical development of the respective
      visual field defects. The rest of the visual system was anatomically intact.

PMID- 1033488
TI  - Acute bacterial meningitis secondary to gamma hemolytic streptococcus. Case
      report and review of the literature.
AB  - Gamma hemolytic streptococcal meningitis in a 17-year-old boy resulted in a
      severe purulent reaction and death. Review of the literature shows only one other
      case of a gamma hemolytic streptococcus as the cause of bacterial meningitis in
      the absence of endocarditis.

PMID- 1033489
TI  - Erythrocyte shape in Duchenne muscular dystrophy.
AB  - In a controlled and blind study we were not able to identify any abnormality of
      erythrocytes of eight patients with Duchenne muscular dystrophy compared with
      seven approximately age-matched unaffected siblings (six males, one female step
      sibling). Erythrocyte morphology was found to be very sensitive to various types
      of cell treatment. At this time, erythrocyte morphology, evaluated by the
      techniques used, should not be considered an established diagnostic test for the
      Duchenne muscular dystrophy patient or carrier.

PMID- 1033490
TI  - Regional differences in GABA uptake.

PMID- 1033491
TI  - Locked-in syndrome caused by a tumor.

PMID- 1033492
TI  - Comparison of radionuclide scans with computer-assisted tomography in diagnosis
      of intracranial disease.
AB  - Radionuclide brain scans were compared with computer-assisted tomography (CAT)
      for the diagnosis of intracranial disorders in 297 patients. The diagnosis was
      confirmed in 281 patients who formed the population for the study. The
      radionuclide scan was false positive for 12 patients (3.9 percent) and false
      negative for eight (2.6 percent). The CAT was false positive for three patients
      (1 percent) and false negative for one (0.3 percent). In the 133 patients in whom
      both tests were negative, no evidence of central nervous system pathology has
      been found during the 6 to 18 month follow-up. Brain tumors and intracerebral
      hemorrhage are more readily detectable with CAT.

PMID- 1033493
TI  - [Endemic goiter in Nepal. Comparisons with endemic goiter in the Piedmont].
AB  - Comparison of certain features of endemic goitre in the Khumbu district of Nepal
      and Piedmont is reported. Cases in the younger generations were observed in both
      areas. In Khumbu, the incidence of goitre in schoolchildren was 75% and cases
      were even noted in children who had been receiving iodine prophylactic management
      (injections of iodised oil: 500-1000 mg/yr) for at least three years. The iodine
      content of drinking water and the most commonly eaten foods was determined.
      Values were very low and a daily intake of not more than 30 mug was calculated.
      The findings are in line with metabolic studies carried out by other workers in
      Upper Khumbu. While it is clear that ambiental iodine deficiency is much higher
      in Khumbu than in those areas of Piedmont where goitre is most markedly endemic,
      the inadequacy of preventive iodine administration measures, and environmental
      features common to both areas, suggest that iodine deficiency is a concomitant
      factor and not the prime cause of endemic goitre.

PMID- 1033494
TI  - Occupational factors affecting health.

PMID- 1033495
TI  - The occupational health nurse as a mental health counselor.

PMID- 1033496
TI  - A star spangled idea.

PMID- 1033497
TI  - Preparation of objectives for continuing education programs.

PMID- 1033498
TI  - The expanded role.

PMID- 1033499
TI  - Evaluation of a new single-use thermometer.

PMID- 1033500
TI  - Quantitative assessment of perilymph sources.
AB  - The problem of the perilymph origin--influx of cerebrospinal fluid (CSF) versus
      ultrafiltration within the cochlea--cannot be solved by mere qualitative proofs
      of tracer passage through the cochlear aqueduct. In order to gain quantitative
      data on the possible perilymph sources, an experimental study was designed to
      follow the time course of dye concentrations in the cisternal CSF and in the
      perilymph after tracer injection into the CSF at the vertex. By comparing the
      resulting concentration peaks in both fluids, the mean peak of the perilymph
      tracer concentrations was found to reach 36% of the maximum CSF concentration
      only. It is concluded that the local perilymph production within the cochlea
      exceeds the influx of CSF by a ratio of about 2:1. A working hypothesis of the
      double perilymph origin is discussed.

PMID- 1033501
TI  - Simplified acoustical measurement of tubal opening.
AB  - A device is discussed in which tubal opening as one of the functions of the
      Eustachian tube can be measured by expressing the opening phenomena acoustically.
      The features of the present device are the following: introduction of the test
      sound of 2,000 Hz, 85 dB, SPL, directly to the tubal opening through the tubal
      catheter and recording of fluctuations of the sound pressure obtained at the
      external auditory meatus during swallowing. The results of model experiment made
      of resin were 85 dB, SPL, at the speaker, 76 dB, SPL, at the end of tubal
      catheter and 78 dB, SPL, at the external auditory meatus. In the model experiment
      it was also demonstrated that the height of spike waves depends on the extent of
      tubal opening and that the continuity of spike waves depends on the duration of
      tubal opening. Furthermore, in the present method, there was no so-called basic
      amplitude, seemingly due to the resonant effects or the direct passing sound, and
      the opening phenomena were correctly expressed. In the measurement on normal
      adults it was found that variability of the spike wave pattern between subjects
      was largely depending on individual subjects, and also some intra-subject
      variability of successively recorded spike waves on the same subject was noted.
      It was shown that gradual recovery of spike wave patterns occurred from initial
      water swallowing to successive dry swalllowing.

PMID- 1033502
TI  - Vertigo and rocking sensation. A clinical analysis.
AB  - A vertigo perceived as a spinning sensation outside the head indicates a somatic
      vestibular disturbance including a Menier's disease. A turning sensation inside
      the head indicates a functional or vascular disorder while a sensation of
      unsteadiness often as if being slowly rocked indicates a functional disorder.

PMID- 1033503
TI  - Primary cancer of the larynx associated with primary lung cancer. Report of 21
      cases, 14 with autopsy findings and 7 biopsies.
AB  - The present paper reports 21 cases (14 autopsies and 7 biopsies) of associated
      primary cancers of the larynx and the lung. This association is by no means
      uncommon, the laryngeal lesion being usually the first to appear. Mulitple
      primary cancers--of the same or of a different histologic type--tend to occur in
      the same organ or organ system, either simultaneously or after a time interval.
      In case of synchronous primary malignant tumour of the larynx and lung the most
      lethal cancer (the lung cancer) must be managed first. Cancer patients are more
      likely than other individuals to develop a second primary malignant tumour.
      Laryngectomized patients should be followed-up possibly by means of cytologic
      examinations of bronchial secretions and chest X-rays at short intervals for
      early detection of a possible second primary malignant pulmonary lesion.

PMID- 1033504
TI  - Concentration of immunoglobulins in the tonsils.
AB  - The concentration of various immunoglobulins in the faucial tonsil was determined
      and expressed as a portion of the total protein centration of IgA rises with age
      while that of IgM falls. IgE was found to be relatively high and the highest
      levels of all immunoglobulins examined were noted in hypertrophied tonsils. They
      were lowest in the atrophic tonsils of children and in adult tonsils. The results
      are discussed in their relevance to the overall immunological function of the
      faucial tonsil.

PMID- 1033505
TI  - [Effect of neuroemotional stress on the lipid content of the blood serum and
      aorta tissue of ovariectomized rats].

PMID- 1033506
TI  - [Characteristics of the daily rhythms of carbohydrate and lipid metabolism in the
      normal rat liver and in alcoholic intoxication].

PMID- 1033507
TI  - Role of conditioned reinforcers in the initiation, maintenance and extinction of
      drug-seeking behavior.
AB  - The development of a secondary reinforcer as a result of associating a neutral
      stimulus (buzzer) with intravenous (IV) doses of morpine was studied in rats.
      Secondary reinforcement developed in the absence of physical dependence and
      followed the association of the stimulus with either response-contingent or non
      contingent injections of morphine. Strength of the conditioned reinforcer,
      measured in terms of responding on a lever for the stimulus plus infusion of
      saline solution, was proportional to the unit dosage of morphine employed in
      pairings of buzzer and drug. When extinction of the lever-press response for IV
      morphine was conducted (by substituting saline for morphine solution) in the
      absence of the conditioned reinforcing stimulus, it was seen later that the
      stimulus could still elicit lever responses, until it too had been present for a
      sufficient interval of non-reinforced responding. Similarly, extinction of the
      response for morphine by blocking its action with naloxone in the absence of the
      stimulus did not eliminate the conditioned reinforcement. Another study showed
      that a passive, subcutaneous (SC) dose of morphine served to maintain lever
      pressing on a contingency of buzzer plus saline infusion. Furthermore, the
      stimuli resulting from the presence of morphine (after a SC injection) were able
      to reinstate the lever-responding with only the buzzer-saline contingency when
      such responses had previously been extinguished. Moreover, it was shown that d
      amphetamine could restore responding under the same conditions, and that morphine
      could also do so for rats in which the primary reinforcer had been d-amphetamine.
      It is suggested that animal data such as these show that procedures designed for
      the elimination of human drug-taking behavior must take into account secondary
      reinforcers as well as the primary reinforcer(s).

PMID- 1033508
TI  - Alleviation of narcotic withdrawal syndrome by conditional stimuli.
AB  - We systematically paired auditory, olfactory, and social stimuli with each
      injection of morphine in rats. We found that, when morphine was kept constant at
      a low dose, the external stimuli acquired the property of a conditional stimulus
      (CS) to cause hyperthermia which was antagonized by naloxone. In rats in which
      morphine doses were regularly increased to cause morphine dependence, the CS
      presented during withdrawal, caused reduction in withdrawal signs (wet shakes,
      hypothermia, aggression) and produced hyperglycemia as well as elevation of
      striatal homovanillic acid. CS-induced alleviation of withdrawal hypothermia was
      blocked by mecamylamine, phenoxybenzamine, haloperidol, benztropine or naloxone
      but not by cyproheptadine or propranolol.

PMID- 1033509
TI  - [Bioelectrical activity of the brain in the hypomenstrual syndrome].

PMID- 1033510
TI  - [Case of cesarean section and subsequent supravaginal removal of the hemorrhaging
      uterus].

PMID- 1033511
TI  - [Human placental antigens].

PMID- 1033512
TI  - [Surgical treatment of isthmo-cervical insufficiency outside pregnancy].

PMID- 1033513
TI  - Tension pneumothorax: a teaching model.
AB  - A TPT induced in a small rabbit is an excellent teaching model for the treatment
      of a TPT in the small human neonate. Pediatric housestaff, neonatal nurses, and
      others have utilized this model to gain confidence and expertise in the diagnosis
      and treatment of TPT. The rabbit model is inexpensive, readily available, and
      recreates the clinical condition of a TPT in an educational environment.

PMID- 1033514
TI  - Renal intracortical blood flow distribution, function and sodium excretion in
      response to saline loading of anesthetized and unanesthetized dogs.
AB  - In order to study the effect of anesthesia on the canine response to saline
      loading, experiments were performed on 10 dogs, first while awake and then during
      pentobarbital anesthesia. Individual kidney function and intrarenal blood flow
      response to saline loading (7.5% body weight) were measured in each condition and
      all data are reported as the average of a single kidney. CIN is considerably
      reduced under anesthesia (24.7 +/- 3.2 vs. 43.2 +/- 3.9 ml/min, P less than
      0.01). A directionally similar reduction of PAH clearance was noted (89 +/- 17
      vs. 122 +/- 13 ml/min). The natriuretic response to saline loading of the dogs
      reached 290 +/- 61 muEq/min while awake, but only 70 +/- 27 muEq/min while
      anesthetized. No measurable increase of CIN or CPAH occurred in response to
      saline loading either in the anesthetized or unanesthetized state. The
      natriuresis was entirely due to a rise of CNA/GFR in both circumstances. The
      change of CNA/GFR in response to saline load was also appreciably larger while
      awake (1.2 leads to 4.7% vs. 0.7 leads to 1.8%). Although the fraction of blood
      flow to the outermost quarter of the kidney was initially the same (31 +/- 3 vs.
      29 +/- 3%) awake or anesthetized, the changes with saline loading were in the
      opposite direction and the values reached were significantly different (37 +/- 3,
      awake, vs. 27 +/- 3%, P less than 0.05). We conclude that while increased outer
      cortical blood flow is not necessary for natriuresis, it may occur during sodium
      loading and may facilitate sodium excretion.

PMID- 1033515
TI  - Leg muscle blood flow during reactive hyperemia. Effects of different body
      positions, and of subatmospheric pressure.
AB  - In normal man at rest transition from the supine to the upright body position is
      accompanied by autoregualtion of the blood flow to tissues in the dependent
      extremities. In 11 young healthy males the influence of postural changes and
      external pressure changes on the blood flow in the anterior tibial muscle during
      reactive hyperemia was studied. The muscle blood flow was evaluated by means of
      the Xenon-133 wash-out technique. Transmural pressure changes in the resistance
      vessels were estimated by measuring the systolic blood pressure at ankle level,
      using the strain-gauge plethysmograph technique. The mean leg muscle blood flow
      increased from 48 ml - 100 g-1 - min-1 in a body position with the legs elevated
      65 cm above heart level, to 101 ml - 100 g-1 - min-1 in the supine position, and
      to 151 ml - 100 g-1 - min-1 in a sitting position with dependent legs 70 cm below
      heart level. The muscle blood flows increased from 92 ml - 100 g-1 - min-1 at
      ambient pressure to 139 ml - 100 g-1 - min-1 at a subatmospheric pressure of -50
      mm Hg. The differences were highly significant (P less than 0.001). Systemic
      blood pressure measured at heart level did not change during postural changes and
      external pressure changes. The post-ischemic muscle blood flow was found to
      increase with the increasing vascular transmural pressure. It is concluded that
      during reactive hyperemia the normal compensatory vaso-reactions can be
      inactivated, so that the vessels react passively to changes in the transmural
      pressure.

PMID- 1033516
TI  - Passive stress relaxation followed by active contracture in vertebrate smooth
      muscles (taenia coli of the guinea pig).
AB  - 1. The time course of stress relaxation following stretch was investigated in the
      taenia coli of the guinea pig in the relaxed (Ca2+ free bath solution with D 600)
      and in the contracted state (depolarization by KCl or K2SO4 in excess). The
      mechanical tension was standardized with respect to the volume of the samples. 2.
      The tension obtained by a constant stretch of 2.5 mm of the 5-15 mm samples was
      highest after K2SO4-depolarization (K+ = 180 mval/l) and lowest in the relaxed
      muscles. Muscles contracted by KCl in escess (K+ = 60 mval/l) showed intermediate
      values. 3. The decrease of tension by stress relaxation to a nearly constant
      residual value is rapidly observed in contracted muscles during about 10 s. For
      the relaxed muscles the same changes are slower and take place in nearly 1/2 h.
      4. The relations between the extent of stress relaxation (R) and its derivative
      in time (dR/dt) can be expressed by a hyperbolic function. Analogous behaviour
      was already noted in previous studies primarily on creep. 5. The different
      behaviour of the muscle in the different bath solutions used is discussed with
      respect to the mathematical relations just mentioned. 6. Long term active
      reactions of depolarized muscles following stretch and stress relaxation are
      noted.

PMID- 1033517
TI  - Effects of acute cold exposure on the distribution of cardiac output in the
      sheep.
AB  - Conscious adult Merino sheep were studied in a thermoneutral environment and then
      during cold exposure. Microspheres labelled with 141Ce, 51Cr, 85Sr, and 46Sc were
      used to measure blood flow (Q) in most tissues of the body. (Microspheres
      labelled with 125I were found to be unsatisfactory.) Cold exposure which caused a
      marked decrease in skin surface temperature and mild, continuous shivering but no
      change in deep body temperature, was associated with mean increases in oxygen
      consumption, heart rate, and cardiac output (C.O.) of 100%, 62%, and 48%,
      respectively; blood pressure and total peripheral resistance were unchanged.
      There was approximately a 6-fold increase in Q in perirenal white adipose tissue,
      and a 3- to 4-fold increase in muscles of the upper foreleg and hindleg, and the
      intercostals; myocardial Q also increased significantly. There was a marked
      decrease in Q in skin of the legs and ears, in the maxillo turbinals and in the
      nasal mucosa, and a decrease in the total proportion of C.O. passing through
      arteriovenous anastomoses. Thus, not only did C.O. increase, but there was a
      redistribution appropriate to meet the challenge with which the animal was
      confronted.

PMID- 1033518
TI  - Mechanism of inhibition of gastric acid secretion by hypertonic solutions and
      vasopressin.
AB  - An experiment was performed in female rats in order to assess the influence and
      mechanism underlying the effects of hyperglycemia, hypertonic saline and
      vasopressin upon the gastric acid secretion and mucosal blood flow (MBF).
      Infusion of isotonic saline did not alter acid output and gastric clearance of
      plasma aminopyrine whereas hypertonic solutions (20% glucose or 3% NaCl)
      significantly increased plasma osmolality and decreased the acid secretion within
      30 min and recovered to normal levels after 2 h. Vasopressin also effectively
      inhibited acid secretion. Both hypertonic solutions and vasopressin decreased the
      mucosal blood flow. However, the ratio (R) of MBF to gastric secretory rate which
      is a helpful guide to the mechanism of secretory inhibition did not significantly
      change in either case. We concluded that all three agents probably had a direct
      action on secretion rather than decreasing MBF. The mechanism of inhabition of
      acid secretion and its relationship to MBF was suggested and discussed.

PMID- 1033519
TI  - Acclimatization of rats to moderate heat: body water distribution and
      adaptability of the submaxillary salivary gland.
AB  - Changes in plasma and extracellular fluid volumes were studied in rats during
      exposure to 35 degree C for 28 days. In addition the adaptability of the
      submaxillary salivary gland to these conditions was studied by measuring its
      weight, plasma and extracellular volumes during the acclimatization period. Major
      changes in parameters studied occurred during the first 10 days of
      acclimatization. Total plasma volume on day 10 was less than in controls (P =
      0.02), but from then on returned to normal values. Extracellular fluid volume was
      expanded for most of the period. An enlargement of the submaxillary salivary
      gland was present during the whole period, but maximal enlargement was observed
      on day 10 (42%). On day 28 the gland was 14% larger. No changes in plasma and
      extracellular volumes of the gland were observed. It appears that due to
      redistribution of the blood pool at the beginning of heat exposure, plasma and
      extracellular volumes remain constant.

PMID- 1033520
TI  - The influence of cardioactive steroids, metabolic inhibitors, temperature and
      sodium on membrane conductance and potential of crayfish giant axons.
AB  - 1. The resting membrane potential and the current-voltage relation were measured
      in crayfish giant axons before and after treatment with cardioactive steroids,
      metabolic inhibitors, extracellular sodium depletion and low temperature. 2. The
      membrane resistance of axons treated with cardioactive steroids, metabolic
      inhibitors, and low extracellular sodium was reduced by 30-53% depending on the
      treatment. Low temperature also caused a decrease in the membrane resistance of
      the axon but the decrease was limited to potentials around the resting membrane
      potential. The temperature response of sodium depleted or ouabain treated axons
      was an increase in resistance at all points along the current-voltage relation.
      3. All inhibitors and low temperature caused a depolarization of the membrane
      potential. Ouabain and strophanthidin were the most effective, reducing the
      membrane potential by an average of 9.6 mV in 10-20 min. Low sodium did not cause
      a depolarization but consistently reduced the membrane resistance by an average
      of 30%. 4. The data suggest that there is an interaction between the activity of
      the ouabain-sensitive transport system and resting membrane resistance in the
      crayfish axon.

PMID- 1033521
TI  - The influence of chloride on the ouabain-sensitive membrane potential and
      conductance of crayfish giant axons.
AB  - 1. Resting potential and current-voltage relation were measured in crayfish giant
      axons bathed in chloride-free and sodium-free solutions with and without ouabain.
      2. Chloride-free solution caused a transient depolarization but did not alter the
      steady-state membrane potential. Utilizing isethionate as an anion substitute,
      the membrane resistance increased 12.5%. 3. In the absence of extracellular
      chloride, ouabain (0.5-1 mM) depolarized the axon 6-7 mV. The shape of the
      current-voltage relation did not change but the curve was shifted along the
      current axis. 4. These results indicate that ouabain inhibits a steady-state
      hyperpolarizing electrogenic pump current of approximately 3 muA/cm2. 5.
      Extracellular sodium removal from axons equilibrated in chloride-free solutions
      transiently hyperpolarized the membrane 6-7 mV without a change in membrane
      resistance. The transient hyperpolarization was ouabain and temperature
      sensitive. The steady-state potential reached in sodium-free and chloride-free
      solution was not ouabain sensitive. Temperature sensitivity of the steady-state
      membrane potential was greatly reduced. 6. The transient hyperpolarization
      produced by extracellular sodium removal was metabolically driven and may present
      the expression of a sodium efflux transport current of 7.0-7.5 muA/cm2. 7. Using
      electrophysiologically measured parameters, sodium and potassium conductance,
      influx and efflux currents and the coupling ratio for sodium/potassium transport
      are calculated from a modification of the conductance equation. 8. The
      sodium/potassium transport coupling ratio for steady-state conditions was
      estimated at 5:3 (1.67:1).

PMID- 1033522
TI  - Use of endogenous triglycerides to support gluconeogenesis in the perfused
      isolated rat liver.
AB  - The carbon balances in isolated perfused rat liver during gluconeogenesis from L
      alanine and sodium L-lactate indicate that assuming the substrate unaccounted for
      were fully oxidized the energy yielded was not sufficient to support the observed
      rates of glucose synthesis. This observation indicates that endogenous substrates
      must also be oxidized. The possibility that endogenous fatty acid oxidation was
      the source of the energy needed to support glucose synthesis was investigated by
      measuring the rate of 14CO2 formation from tracer quantities of added [U-14C]
      palmitate. Short pulses of L-alanine or sodium L-lactate infusion produced an
      increased rate of 14CO2 production paralleled by increases in oxygen uptake
      indicating that more endogenous fuel is being mobilized. That the rate of 14CO2
      output is an expression of fatty acid mobilization was supported by experiments
      demonstrating that the addition of octanoate to dilute the fatty acid pool
      produced an immediate fall in the rate of 14CO2 output. On the other hand, the
      administration of glucose produced no changes in oxygen uptake or 14CO2 output.
      However, lactate even in the presence of glucose induced a rise in 14CO2
      production which occurred in parallel with the enhancement in oxygen uptake. It
      is concluded that mobilization of hepatic endogenous fatty acid is a metabolic
      event intimately associated with enhancement of gluconeogenesis. Consequently the
      control of the different steps of this process may indirectly control
      gluconeogenesis.

PMID- 1033523
TI  - The effect of capsaicin on temperature regulation of the rat.
AB  - 1. Subcutaneous injection of capsaicin (6-11 mg, or 21-66 mg cumulative),
      permanently reduced the capacity of rats to withstand a hot environment, as
      described by Jancso-Gabor et al. (1970). 2. The treated rats thermoregulatory
      behaviour was not different from that of control rats, both in hot and cold
      environments. 3. Saliva secretion was decreased in a hot environment, and the
      weight of the submaxillary glands was reduced in capsaicinized rats. 4. It is
      concluded that hyperthermia present in treated rats when subjected to a warm
      environment is not due to a disruption of sensu stricto temperature regulation,
      but rather to a decreased salivary secretion. Whether this decrease has a central
      or a peripheral origin is not known.

PMID- 1033524
TI  - The effect of heart rate on the membrane responsiveness of rabbit atrial muscle.
AB  - The maximum rate of rise of action potentials in myocardial fibers of the rabbit
      atrium decreases with an increase in heart rate. This decrease of the dV/dt max
      is accompanied by a decrease of the diastolic transmembrane potential prior to
      the moment of activation (take-off potential). Comparison of the membrane
      responsiveness curve (relation between dV/dt max and take-off potential) as
      measured by varying the extracellular potassium concentration at a fixed rate of
      stimulation, with the effect of changes in the frequency of stimulation on dV/dt
      max and take-off potential made clear that the fall in dV/dt max after a sudden
      increase in heart rate was stronger than could be explained by the concomitant
      decrease of the take-off potential alone. This implicates that the membrane
      responsiveness itself is heart rate dependent. A possible explanation for this
      observation is that when heart rate is increased the active Na/K pump is not able
      to maintain the intracellular concentration of Na and K at the original level.
      Acceleration of the heart will lead to an intracellular loss of potassium and a
      gain of sodium. The first causes a diminishment of the diastolic membrane
      potential which according to the membrane responsiveness curve is attended with a
      decrease of the dV/dt max. The second results in a decrease of the sodium
      concentration gradient and therefore in a further reduction of the dV/dt max.
      This hypothesis was confirmed by experiments with ouabain added to the perfusion
      fluid. Ouabain, which is known to inhibit the Na/K pump, caused a decrease of
      both the take-off potential and dV/dt max that was completely comparable with the
      effects of an increase of the frequency of stimulation. In addition, observation
      of the time course of the changes in dV/dt max and membrane "resting" potential
      after a sudden change in the rate of stimulation, gave support to the
      electrogenic concept of the active Na/K pump in cardiac muscle.

PMID- 1033525
TI  - Oxygen transport capacity of the capillary blood within the carotid body.
AB  - Local deltaPo2 deltat in the carotid body after perfusion stop depends on the
      oxygen consumption of the tissue and the apparent O2 solubility coefficient alpha
      of the blood. Oxygen consumption of the carotid body tissue can be determined by
      measuring the local deltaPo2 deltat with Po2 needle electrodes after Krebs
      Henseleit perfusion. Assuming the same deltaPo2 deltat for the blood-perfused
      carotid body the actual Po2 decrease can be used to estimate the hemoglobin
      content of the tissue. The influence of hemoglobin is described by the factor
      alpha/alpha. Control values measured in the Krebs-Henseleit-perfused carotid body
      yielded values of alpha/alpha = 0.8-3. In a series of 11 blood-perfused carotid
      body preparations with 105 perfusion stops the quotient alpha/alpha changed with
      arterial Po2. At Po2 values higher than 100 Torr alpha/alpha was between 0.8 and
      2. This value thus was in the same range as the control values. Below 100 Torr
      higher values up to 11 were observed. Since a blood-perfused tissue (15 g% Hb)
      would have an alpha/alpha of about 128, we conclude that the carotid body is
      mainly perfused by plasma, and that with decreasing arterial Po2 more red cells
      flowed through the carotid body.

PMID- 1033526
TI  - Lactate oxidation by skeletal muscle during sustained contraction in vivo.
AB  - Estimation of lactate oxidation in vivo was carried out by a tracer technique in
      the muscles of the lower hindleg of the dog during tetani of different duration.
      The fractional (%) rate of lactate oxidation increased markedly, compared with
      that of the resting muscle, after the first 2 min of stimulation. Lactate
      oxidation afforded a large contribution to the total oxygen consumption. Fatigue
      appeared to play a role in limiting lactate oxidation in the later phase of
      sustained contraction.

PMID- 1033527
TI  - A time- and voltage-dependent potassium current in the rabbit sinoatrial node
      cell.
AB  - Voltage clamp experiments were conducted in the rabbit sinoatrial node (S-A node)
      using the double microelectrode technique. When the membrane was repolarized to
      the resting potential after depolarizing test pulses, the outward current slowly
      decayed to the steady level (outward current tail). The magnitude of the outward
      current tail was a sigmoid function of the amplitude of the preceding
      depolarization. The degree of activation of this current varied from 0 at about 
      50 mV to 1 at about +20 mV. The time course of the current change was a simple
      exponential and was independent of the preceding depolarization. The reciprocal
      time constant appeared to be a U-shaped function of the membrane potential with a
      minimum value of about 3s-1 at -40 mV. The instantaneous current voltage relation
      was an inward-going rectifier, but showed no detectable negative slope. The
      reversal potential, obtained between 10 and 50 mM [K]o, decreased with a slope of
      58 mV for a 10-fold increase in [K]o. These findings indicate that the outward
      current tail in the S-A node cell is attributable to a single component of K
      current (pacemaker current component). The pacemaker current component is mainly
      responsible for the slow diastolic depolarization.

PMID- 1033528
TI  - Evolution in vivo of the synthesis rate of catecholamines in various peripheral
      organs of the rat during cold exposure.
AB  - The synthesis of catecholamines (CA) has been studied in the heart, spleen,
      submaxillary glands and adrenals of rats exposed to 4 degrees C for 2.5, 24 or 48
      h. The synthesis rate has been estimated 30 min after an i.v. injection of 3H
      tyrosine (TY) by the evaluation of the ratio: 3H-CA specific activity/3H-TY
      specific activity. In the sub-maxillary glands, cold exposure reduced the
      noradrenaline (NA) synthesis by 40% at times 24 and 48 h. In the spleen, NA
      synthesis was multiplied by a factor 1.6 at times 2.5 and 24 h and 2.8 at time 48
      h. In the heart, it was increased by a factor 1.3 after 2.5 h, 2.8 after 24 h and
      5.5 after 48 h: an important fall in cardiac NA level was observed during the
      first 24 h of cold exposure indicating that the synthesis capability was
      unsufficient to compensate the cold-induced NA release. In the adrenals,
      adrenaline + NA synthesis was not significantly enhanced during the first 24 h of
      cold exposure and increased by a factor 2.4 at time 48 h. The important increases
      in CA synthesis which are observed during the 24-48 h interval are likely
      consecutive to the induction of tyrosine hydroxylase which has been reported in
      the rat exposed to cold.

PMID- 1033529
TI  - Simple and stable techniques for recording slow-wave sleep.
AB  - 1. A combination technique of a telemetric system and a Walter-type analyzer have
      been used in the rat to allow on-line display of the sleep-waking cycle of a
      freely-moving animal on three consecutive days. 2. The characteristics of slow
      wave sleep can be analyzed completely by this technique. 3. Telemetric recording
      of the integrated slow wave is a good method that allows faster and accurate
      scoring of slow waves to measure the length of sleep in freely-moving animals.

PMID- 1033530
TI  - Referencing procedure for location of lumbosacral alpha-motoneurons.
AB  - This report presents a simple referencing procedure to facilitate microelectrode
      positioning within a desired motor nucleus in the cat spinal cord. The procedure
      is used in conjunction with the conventional technique of interpreting
      microelectrode position in the ventral gray column on the basis of the relative
      amplitude of antidromically or orthodromically evoked field potentials from
      select motor nuclei. The procedure optimizes the use of a single surface
      anatomical landmark such that the nuclei can be quantitatively referenced both
      horizontally and sagitally.

PMID- 1033531
TI  - Single nephron glomerular filtration rate ratios of superficial, intercortical
      and juxtamedullary nephrons in rats during development.
AB  - In 20, 40 and 60-day-old rats the filtration rate was studied using Baines
      modification of Hanssen's Na4Fe (14CN)6 method enabeling the determination of
      single nephron glomerular filtration rate (SNGFR) ratio between superficial (S),
      intercortical (I) and juxtamedullary (J) nephrons. The proximal tubule lengths
      were determined as well. A close correlation was obtained between age and S/I,
      I/J and S/J of proximal tubule lengths and between age and I/J, S/J 14C
      activities of ferro-cyanide. Presented findings confirm the data on the
      increasing role of superficial nephrons in the course of postnatal development of
      rat.

PMID- 1033532
TI  - Observations on blood flow related electrical impedance changes in rigid tubes.
AB  - Mammalian blood in pulsatile flow through a rigid tube has been shown to be
      anisotropic with regard to its electrical conductivity. When flow increases there
      is a rise in conductivity in the longitudinal and a fall in the radial direction.
      These changes are caused by flow-dependent variations in the orientation of the
      disk-shaped erythrocytes.

PMID- 1033534
TI  - Porton Down; the microbiological research establishment.

PMID- 1033533
TI  - [The cell count in milk of goats].
AB  - Weekly milk samples were taken from mammary halves from 30 goats from 8 different
      herds each with from 2 to 5 experimental animals throughout their lactation
      periods. The physiological variations in the cell counts of goats milk during
      lactation were investigated by a projection microscope. Only small variations
      were found in the average cell counts in milk samples from goats in the same
      herd, but big variations from one herd to another (Table I and Fig. 3.). The
      curves of the average cell counts in milk samples of 5 herds showed a rise at the
      beginning of the season at pasture (Fig. 1 and Fig. 2). Also in the housed
      periods the cell count showed transitory rises. The herd with the lowest average
      cell count (220,000/ml) was milked by an ordinary bucket milking system, while
      the herd with the highest average cell count (1,490,000/ml) was milked by a
      pipeline milking system. Five herds milked by machine had an average cell count
      of 720,000/ml and three herds milked by hand 540,000/ml. All the herds in the
      material had an average cell count of 680,000/ml.

PMID- 1033535
TI  - Diagnosis and differential diagnosis of colonic diverticulitis.
AB  - A patient over 40 years of age who complains of lower abdominal pain,
      constipation or diarrhea or both, and increased flatulence should be suspected of
      having diverticulosis. When pain becomes more severe and persistent,
      diverticulitis must be considered. Diagnosis depends on roentgen demonstration of
      the presence of diverticula. Sigmoidoscopy and barium enema study are essential
      to exclude coexisting disease but in diverticulitis may need to be postponed
      until severe local and systemic signs of inflammation have subsided. A number of
      diseases can simulate diverticulitis, and differential diagnosis may present
      considerable difficulty. Irritable colon syndrome and acute appendicitis may be
      indistinguishable clinically from diverticulitis. Differentiation from carcinoma
      is usually not difficult, but exclusion of coexistent carcinoma may be impossible
      except by resection. Ulcerative colitis is also easily distinguished except when,
      rarely, it coexists. Crohn's disease of the colon is less easily differentiated,
      especially in patients over 40, in whom the two diseases often coexist. Other
      colonic diseases, such as ischemic colitis, and pelvic inflammatory diseases
      usually show characteristic features which make them readily distinguishable from
      diverticulitis.

PMID- 1033536
TI  - Toleracne to equine IgG after immunosuppression in patients with multiple
      sclerosis.
AB  - Fourteen patients with multiple sclerosis were given two tolerizing doses of
      equinine gammaglobulin followed by equine antilymphocyte globulin. Twelve were
      sufficiently tolerant to have no clinical symptoms of hypersensitivity, no skin
      reactivity and normal plasma clearance rates. Some tolerance was lost in the
      following months revealed by immediate wheal and flare skin reactions. No
      correlation between success in tolerance induction and beneficial effects on the
      disease process could be established in the short term follow-up period of this
      pilot study.

PMID- 1033537
TI  - The in vitro assessment of anti-human lymphocyte globulin.
AB  - A simple reproducible in vitro test of anti-human lymphocyte globulin activity is
      discribed. The method is a "microtitre" complement-fixation test using human
      platelets as a source of antigen, guinea-pig complement and an amboceptor of
      sheep red blood cells sensitized by rabbit anti-sheep haemolysin.

PMID- 1033538
TI  - Conditions affecting plasma amino acid patterns in chickens fed practical and
      purified diets.
AB  - Experiments were conducted to investigate plasma free amino acid concentrations
      in the chick. After one hour of fasting, total plasma amino acid concentration
      decreased to approximately half of the full-fed value. Within three to six hours,
      most amino acids had returned toward the full-fed level but did not exceed it
      throughout a 48 hour period of starvation. However, after 48 hours fasting
      lysine, threonine, and isoleucine accumulated three-fold, two-fold and two-fold
      of the full-fed level, respectively. Serine and glutamic acid exceeded the full
      fed level at three hours and then declined. Alanine reached its highest level
      after six hours of fasting and then declined. In full-fed chicks diurnal
      variations of plasma free amino acid concentrations were observed. The lowest and
      highest concentrations were observed at 11 a.m. and 8 to 11 p.m., respectively
      under a 24 hr-lighting. Reference plasma amino acid patterns are reported for
      chicks fed a practical diet ad libitum. In day-old chicks, concentrations of
      total amino acids, methionine plus one half cystine, lysine, and arginine were
      high. Alanine and glutamic acid concentrations were low. Most amino acid
      concentrations declined gradually during the first four weeks of life, but
      methionine plus one half cystine, phenylalaine, threonine and serine
      concentrations decreased sharply between two and four weeks. Lysine concentration
      continued to decrease in chicks fed the starter diet. At 20 weeks, plasma amino
      acid concentrations had decreased considerably except for methionine plus one
      half cystine and basic amino acids. The plasma amino acid pattern for chicks fed
      an isolated soybean protein diet was similar to that of chicks fed the practical
      diet.

PMID- 1033539
TI  - Ovarian 125I transference in the laying Japanese quail: apparent stimulation by
      FSH and lack of stimulation by TSH.
AB  - Six-hour accumulations of 125I were measured in the growing oocytes and thyroids
      of laying Japanese quail injected with 0.002 to 2 mg. of FSH or 0.004 to 4 I.U.
      of TSH per day for six days. FSH at 0.2 and 2 mg./day increased the 125I content
      of the growing oocytes to 1.4 times the control values. The numbers and the total
      weights of these growing oocytes doubled. The egg-laying rate remained unchanged.
      The FSH-induced apparent stimulation of 125 I transference was seen as a
      consequence of the increase in oocyte material rather than to a direct effect of
      FSH on the membranes of the avarian follicular cells. TSH did not increase the
      transference of 125I.

PMID- 1033540
TI  - Effect of biotin and niacin on lipid content of livers in the laying hen.
AB  - Single Comb White Leghorn layers maintained in cages were fed a corn-soy diet
      with a simplified vitamin premix for a 12-week experimental period to determine
      the effect on liver lipid accumulation. Lipid content was only 29.6% of the liver
      dry matter and, therefore, was in the normal range and less than that seen in
      hens with fatty liver syndrome. Adding niacin (44 mg./kg.) or biotin (110
      mug./kg.) either alone or in combination failed to significantly alter liver
      weight or liver lipid content. Liver lipid content of hens fed another diet with
      a more complex vitamin premix also was not significantly different from that of
      hens fed the diet with the simplified vitamin premix. None of the diets
      significantly affected egg production, egg weight, feed consumption or body
      weight changes observed over the 12-week period.

PMID- 1033541
TI  - Diurnal cycles of gastric motlity in normal and fasted turkeys.
AB  - Strain gage transducers were chronically implanted on the muscular stomachs of 12
      young turkeys to study diurnal patterns of gastric motility. Continuous
      recordings were made for several days before and after a period of two or three
      days of fasting. Pronounced diurnal cycles in gastric motility were observed in
      which the frequency and amplitude of gastric contractions were increased during
      the daylight and depressed during darkness. Fasting caused a reduction in both
      frequency and amplitude and, during fasting, the diurnal cycles were somewhat
      obscured. Motility improved upon refeeding and cycles were agina apparent. The
      diurnal cycles appeared to be at least partially regulated by an intrinsic
      biological rhythm.

PMID- 1033542
TI  - Twin pigeon embryos.
AB  - Twin pigeon embryos were found on incubation day 18 in a pipped egg. The egg was
      pipped at the small end. The embryos were dead. Removal of a portion of the shell
      allowed removal of one embryo and revealed the second one. Both appeared normal
      in development and size.

PMID- 1033543
TI  - [Differential changes in serum levels of N-acetylneuramic acid and L-fucose as
      manifestations of physiological and physiopathological adaptation in man.
      Pregnancy as an experimental model. The tumoral, vascular and hepatic diseases as
      possible pathological models].
AB  - In this paper we report on the modifications that normal pregnancy introduces on
      the blood maternal serum concentrations of both N-acetyl maternal serum
      concentrations of both N-acetyl-neuraminic acid which is elevated above normal
      level and L-fucose which on the contrary is diminished. The experiences were
      performed with women in the last trimester of normal gestations. The probable
      physiochemical meaning and biological significance of those such changes are
      discussed in connection both to the maternal physiological adaptation during
      pregnancy and to the possible metabolical changes in intracellular regulation
      that might take place in such a situation. Similarly it is emphasized the
      probability that numerous pathological conditions including malignancy vascular
      diseases and hepatic disorders which course with overt changes in plasma
      glucoproteins might be amenable to present notorious modifications in N
      acetylneuraminic acid and L-fucose plasmatic levels.

PMID- 1033544
TI  - [Fat tolerance curve by intravenous route].

PMID- 1033545
TI  - Primary and secondary prevention among adults: an analysis with comments on
      screening and health education.

PMID- 1033546
TI  - [Immobolization of beta-galactosidase on silochrome].
AB  - Beta-Galactosidase (beta-D-galactoside galactohydrolase 3.2.1.23) from Curvularia
      inaequalis was immobilized by glutaric dialdehyde on gamma-aminopropyl
      triethoxysilane treated porous siliceous carrier silochrome. From the crude
      preparation with a specific activity of 3.1 U/mg immobilized beta-galactosidase
      with an activity of 113 U/g was obtained. The immobilized enzyme did not show
      significant changes in its enzymic properties. The column filled with the
      resultant preparation and used to hydrolyze lactose in milk whey maintained 50%
      of its initial activity after a 30-day work at 50 degrees C.

PMID- 1033547
TI  - The effects of sodium pentobarbital or ether anesthesia on spontaneous and
      electrochemically-induced gonadotropin release.

PMID- 1033548
TI  - A comparison of gamma-butyrolactone and pimozide on serum gonadotrophins and
      ovulation in the rat.

PMID- 1033549
TI  - Plasma prolactin and progesterone during the estrous cycle in the mouse.

PMID- 1033550
TI  - Possible determinants of plasma renin activity in infant rats.

PMID- 1033551
TI  - Glucocorticoid receptors and inhibition of bone cell growth in primary culture.

PMID- 1033552
TI  - Light induced changes in ketamine response in the chick.

PMID- 1033553
TI  - Neuropharmacological interaction between ketamine, and physostigmine, diazepam or
      propranolol.

PMID- 1033554
TI  - Dose-response shifts in the behavioural effects of dopamine agonists and
      antagonists following chronic morphine treatment.

PMID- 1033555
TI  - Acute and chronic effects of morphine and withdrawal from morphine on temperature
      in the cat.

PMID- 1033556
TI  - The effect of narcotic agonists and antagonists on the rat colon.

PMID- 1033557
TI  - Transmission of 14C-benzo(a)pyrene from lactating mice to their offspring.

PMID- 1033558
TI  - Dopaminergic sites involved in morphine withdrawal hypothermia.

PMID- 1033559
TI  - The use of tert-butanol in alcohol dependence studies.

PMID- 1033560
TI  - Temperature dependent interaction of morphine and naloxone on spin labelled
      bovine brain liposomes.

PMID- 1033561
TI  - Papaverine, drug-induced stereotypy and catalepsy and biogenic amines in the
      brain of the rat.
AB  - The effects of papaverine on haloperidol-induced catalepsy and apomorphine
      induced stereotypy as well as brain monoamines concentrations in rats were
      studied. Papaverine increased cataleptogenic effect of haloperidol whilst reduced
      stereotypy induced by apomorphine. Slight but significant decrease in brain
      dopamine concentration was observed in rats treated with papaverine. The present
      study indicates that papaverine has influences upon dopaminergic mechanisms in
      the brain.

PMID- 1033562
TI  - Spontaneous and amphetamine induced head-shaking in infant rats.
AB  - A variable proportion of albino rats 6-11 days old exhibit spontaneous and
      infrequent rotatory head-shaking episodes. This motor pattern is slightly
      anticipated and significantly increased in occurrence and duration by the
      administration of D-amphetamine (5 mg/Kg), with a maximal effect of the drug on
      the 9th day. The rate of amphetamine induced rhythmic head oscillations increases
      with age from below 5 cps on the 5th day to about 9 cps on the 10th day. The
      results are discussed in relation to maturation of both the underlying
      catecholaminergic pathways, activated by D-amphetamine, and the stretch reflex
      systems of the head and neck muscles participating in the rhythmic activity.
      Emphasis is placed on the difference between head-shaking and stereotyped
      activity.

PMID- 1033563
TI  - Relative role of catecholamines in head-shaking of infant rats.
AB  - The relative contribution of catecholaminergic mechanisms in head-shaking (H-S)
      of infant rats was explored by comparing the H-S inducing effects of apomorphine
      and amphetamine in rats from 4-14 days old, and the blocking effect of
      neuroleptic drugs (chlorpromazine and haloperidol) and more specific alpha- and
      beta-adrenergic receptor antagonists (phenoxybenzamine and propranolol), on
      amphetamine induced head-shaking. As apomorphine, but not amphetamine, may induce
      H-S in four-day-old rats, and the latter drug potentiates apomorphine induced H
      S, even in days in which, if injected alone it has no effect, it is suggested
      that both dopaminergic and noradrenergic mechanisms are involved in H-S, thus
      differentiating this motor item from other motor patterns included in stereotyped
      behaviour. This suggestion is further supported by the demonstration that while D
      amphetamine induced H-S is blocked by phenoxybenzamine, other stereotyped motor
      patterns continue unimpaired.

PMID- 1033564
TI  - Cortical administration of somatostatin (SRIF): effect on sleep and motor
      behavior.
AB  - Cortical administration of SRIF in unrestrained, freely moving rats produced an
      early activation, stereotyped behavior patterns and later, coordination
      difficulties often associated with drowsiness. A few animals showed a tendency
      toward paraplegia-in-extension. A considerable, prolonged alteration in the sleep
      waking cycle was also observed. Similar results were obtained in both intact and
      hypophysectomized animals. Intraperitoneal administration of SRIF induced several
      other effects in addition to those seen after cortical application. The latter
      were however, restricted in variety, intensity and duration.

PMID- 1033565
TI  - Abolition of nomifensine-induced stereotypy after 6-hydroxydopamine lesions of
      ascending dopaminergic projections.
AB  - The effects of bilateral focal injections of 6-hydroxydopamine into the zona
      compacta of the substantia nigra (SNC) on nomifensine-induced stereotypy were
      examined in the rat. These lesions reduced neostriatal dopamine levels to less
      than 1 percent of control levels. They also abolished nomifensine-induced
      stereotyped behavior. It is suggested that nomifensine-induced stereotypy is
      mediated via a presynaptic action on dopamine uptake and release.

PMID- 1033566
TI  - Enhancement of the locomotor response to d-amphetamine by olfactory bulb damage
      in rats.

PMID- 1033567
TI  - On the anticataleptic action of cyproheptadine.
AB  - The anticataleptic action of cyproheptadine, a tricyclic compound known as
      antiserotonin, anticholinergic and antihistaminic drug in comparison to that of
      atropine, promethazine, imipramine, desipramine, chlorimipramine and nomifensine
      was studied in rats. The catalepsy induced by spiperon, pimozide or fluphenazine
      was antagonized by cyproheptadine, atropine and promethazine. Imipramine and
      nomifensine were less active, desipramine and chlorimipramine without effect. The
      reserpine- and alpha-methyltyrosine-catalepsy was counteracted by cyproheptadine,
      promethazine and nomifensine, but not by atropine or tricyclic antidepressants.
      Only cyproheptadine and promethazine antagonized the catalepsy caused by a
      combined treatment with reserpine and alpha-methyltyrosine. The pilocarpine
      catalepsy was abolished by atropine, promethazine and nomifensine and unaffected
      by tricyclic antidepressants. Atropine and promethazine antagonized also the
      physostigmine-catalepsy. The catalepsy induced by both cholinomimetic drugs was
      not changed or increased by cyproheptadine. The results presented indicate that
      cyproheptadine differs in its anticataleptic activity from all the drugs used for
      comparison. Possible mechansims of this activity are discussed.

PMID- 1033568
TI  - Response suppression on a mixed schedule of reinforcement during alcohol
      withdrawal.
AB  - Two groups of rats were maintained on a mixed fixed-ratio, fixed-interval
      schedule of food reinforcement until performance was stable. The animals were
      intubated daily with ascending doses of alcohol or water 30 min before each
      session, starting with 4.0 g/kg and increasing to the final dose of 8.0 g/kg. The
      results show that withdrawal from alcohol suppresses responding in all components
      of a mixed schedule and this suppression lasts approximately 14 hours. These
      results support previous reports which suggest that the duration of the
      behavioral aberrations produced by alcohol withdrawal are most severe 6 to 14
      hours post-withdrawal.

PMID- 1033569
TI  - Effects of nicotinic and muscarinic compounds on biting attack in the cat.
AB  - Predatory-like biting attack on a rat, as well as hissing, growling, and other
      threat behaviors, could be induced in normally non-aggressive cats by systemic
      administration of the muscarinic agonist, arecoline (7-12 mg/kg). In contrast to
      arecoline, nicotine was found to suppress aggressive behaviors. Systemic
      administration of nicotine (0.5 mg/kg) prior to arecoline injection resulted in a
      significant reduction in elicited attack and threat behaviors. Furthermore,
      nicotine (0.075-0.500 mg/kg) was found to produce a dose-dependent suppression of
      natural predatory behavior as well. This nicotine-produced suppression of attack
      did not appear to be due to the induction of general malaise, since attack
      suppression could be seen in the absence of general behavioral inhibition, and
      doses of nicotine resulting in complete suppression of attack had little effect
      on food intake. Results indicate that muscarinic and nicotinic compounds can
      exert antagonistic control over some types of aggressive behaviors.

PMID- 1033570
TI  - Ethanol elimination rates in normal and ethanol dependent animals.
AB  - Ethanol elimination rates were determined in rats using an intravenous route of
      ethanol administration after several experimental manipulations. Twenty-four hr
      food deprivation resulted in a 30% reduction to 35 mg/100ml blood/hr in
      elimination rate from a non-deprived rate of 50 mg/100 ml blood/hr. After 2
      months of ethanol drinking (5% v/v), 24 hr starvation resulted in only a 10%
      reduction in elimination rate (45 mg/100 ml blood/hr), and did not increase the
      non-food-deprived rate (49.2 mg/100 ml blood/hr) over that obtained in the above
      animals' drinking water rather than 5% ethanol. Animals which chronically
      overdrank ethanol or water for 3 months on a schedule-induced polydipsia
      procedure, known to result in ethanol physical dependence, showed a decreased
      rate of ethanol elimination (37.9 mg/100 ml blood/hr for water drinkers) in the
      non-food-deprived condition. By providing 750 mg of liver powder daily as a food
      supplement in the ethanol overdrinking regimen, the ethanol elimination rate
      remained at a rate comparable to the normal animal (48.4 mg/100 ml blood/hr).

PMID- 1033571
TI  - The role of hippocampal cholinergic mechanisms in the aquisition of a barpress
      response.
AB  - The role of hippocampal cholinergic mechanisms in learning a bar-press response
      reinforced with food was investigated. Firstly, an interstrain comparison showed
      that mice having a low choline acetyltransferase activity in the dorsal
      hippocampus were quicker to associate the barpress with reinforcement. Secondly,
      when the activity of this enzyme was reduced by a subseizure electrical
      stimulation of the hippocampus learning was accelerated. It is suggested that
      acetylcholine availability at the hippocampal synapses slowed the apparition of
      these learned responses.

PMID- 1033572
TI  - Reinstatement of eating by dopamine agonists in aphagic dopamine denervated rats.

PMID- 1033573
TI  - Influence of diet palatability on the meal taking behavior of hypothalamic
      hyperphagic and normal rats.

PMID- 1033574
TI  - Overeating and obesity produced by interruption of the caudal connections of the
      hypothalamus: evidence of hormonal and metabolic disruption.

PMID- 1033575
TI  - Evidence that maternal ventral skin substances promote suckling in infant rats.

PMID- 1033576
TI  - Olfactory control of aggression in lactating female housemice.

PMID- 1033577
TI  - Adaptation of the glucocorticosterone response to novelty.

PMID- 1033578
TI  - Aggression in male and female mice: evidence for changed neural sensitivity in
      response to neonatal but not adult androgen exposure.

PMID- 1033579
TI  - Interruption of septal connections: effects on drinking, irritability, and
      copulation.

PMID- 1033580
TI  - Ovarian influences on the meal patterns of female rats.

PMID- 1033581
TI  - Cue-dependent amnesia: permanence and memory return.

PMID- 1033582
TI  - Absence of post-fast food compensation in the golden hamster (Mesocricetus
      auratus).

PMID- 1033583
TI  - Progesterone antagonism of aggression-promoting olfactory signals: a time
      dependent phenomenon.

PMID- 1033584
TI  - Schedule dependent and schedule induced behavior at reduced and recovered body
      weight.

PMID- 1033585
TI  - Effects of alloxan induced diabetes on the feeding patterns of rats.

PMID- 1033586
TI  - Imaginary companions, fantasy twins, mirror dreams and depersonalization.
AB  - Illustrative case material is presented to demonstrate genetic linkages between
      the presence of imaginary companions or fantasy twins and extensive mirror play
      in childhood and early adolescence, and the appearance of mirror dreams and
      depersonalization in later adolescence and adulthood. The defensive splitting of
      the self-representations observable in these phenomena is viewed as a means of
      warding off castration anxiety and anxiety about object loss, anxieties which
      arise because of conflicts primarily centering on intense aggressive drive
      derivative wishes. Formulations about depersonalization are discussed.

PMID- 1033587
TI  - Habituation and the structure of the electrodermal system.

PMID- 1033588
TI  - An improved mechanical strain gauge for recording penile circumference change.

PMID- 1033589
TI  - [Tonic structure and model of sleep distortion].

PMID- 1033590
TI  - Dopaminergic influence on withdrawal jumping behavior in morphine-dependent mice.
AB  - Abrupt withdrawal jumping behavior in morphine-dependent mice is accompanied by a
      decrease in brain dopamine turnover and an increase in brain dopamine level which
      parallel strain differences in jumping incidence. Both naloxone-precipitated and
      abrupt withdrawal jumping behavior are inhibited in a dose-dependent manner by
      the dopaminergic agonist apomorphine. A cataleptic dose of the dopaminergic
      antagonist, haloperidol, does not block naloxone-precipitated jumping, but does
      significantly block the inhibition by apomorphine. These findings indicate that
      there may be a decrease release of dopamine in the brain during the expression of
      withdrawal jumping behavior and that dopaminergic activation may be inhibitory to
      this behavior.

PMID- 1033591
TI  - [Regional flow, collaterals, LV function in coronary failure (author's transl)].

PMID- 1033592
TI  - ["Coronary insufficiency" and cardiac nervous system (author's transl)].

PMID- 1033594
TI  - [Rheology in coronary circulation (author's transl)].

PMID- 1033593
TI  - [Accommodation in atrial stimulation and atrioventricular conduction].

PMID- 1033595
TI  - [Blood coagulation in coronary artery disease (author's transl)].

PMID- 1033596
TI  - [Electrocardiograms in coronary insufficiency (author's transl)].

PMID- 1033597
TI  - [Electrophysiological basis of arrhythmias during coronary insufficiency
      (author's transl)].

PMID- 1033598
TI  - [Timing and boundary of the vulnerable period].

PMID- 1033599
TI  - [Right ventricular performance studied in isovolumetric preparation with non
      functioning left ventricle: its relationship to coronary perfusion pressure
      (author's transl)].

PMID- 1033600
TI  - [Radioisotope scanning of the myocardium].

PMID- 1033601
TI  - [A case of pre-excitation syndrome due to possible Mahaim-fiber conduction
      (author's transl)].

PMID- 1033602
TI  - [A new synthetic progesterone in luteal insufficiency].

PMID- 1033603
TI  - [Risks to consumers and PVC workers from vinyl chloride].
AB  - Over the past two years the level of exposure of workers in PVC polymerization
      factories to vinylchloride has been greatly lowered. Thus there should be no
      further cases of so-called vinylchloride disease, which mainly affects the
      connective tissues. Also, the risk of liver hemangiosarcomas should not be higher
      under present working conditions than in the general population. Worldwide, 42
      cases of VC sarcomas have been described among the 20,000 to 40,000 workers
      exposed since 1930. The consumer uptake of VC from PVC-packaged food is almost a
      million times lower than the carcinogenic threshold dose, and this rules out any
      danger arising from that source.

PMID- 1033604
TI  - Suppression by 1,3-butanediol of the ethanol withdrawal syndrome in rats.
AB  - 1,3-Butanediol was tested for its ability to suppress an ethanol with drawal
      syndrome. Male Sprague-Dawley rats were rendered physically dependent on ethanol
      by intragastric administration of ethanol at a dosage of 9 to 15 grams per
      kilogram per day over a 4-day period. A nonintoxicating oral dose of 1,3
      butanediol at 4 grams per kilogram administered after elimination of ethanol from
      the blood was effective against the tremulous and conbulsive components of the
      ethanol withdrawal syndrome in all animals for 1 to 5 hours. This period
      coincided with the time of maximum severity of the withdrawal syndrome, as seen
      in the control animals.

PMID- 1033605
TI  - [Clinical use of elastic tubular bandages].

PMID- 1033606
TI  - [Treatment of acute poisoning with caustics].

PMID- 1033607
TI  - [Emergency medical service in RSFSR and the measures for its further
      improvement].

PMID- 1033608
TI  - Total lipids, cholesterol, phospholipids and inorganic phosphorus in the amniotic
      fluid of premature infants.
AB  - Total lipids, total cholesterol, phospholipids and inorganic phosphorus were
      determined in the amniotic fluid of 36 normal and 12 premature neonates. Total
      lipids, phospholipids and cholesterol were significantly decreased in the
      premature patients and the extent of decrease was more pronounced in patients who
      developed respiratory distress syndrome. On the other hand, inorganic phosphorus
      content of the amniotic fluid was within the normal range.

PMID- 1033609
TI  - Postpartum haemolytic-uraemic syndrome.
AB  - In a young woman a twin pregnancy and uneventful labour were complicated by the
      development of the postpartum haemolytic-uraemic syndrome. A number of unusual
      features of this syndrome were present, including early onset, accompanying
      hepatocellular necrosis, hepatic encephalopathy and bleeding diathesis. Early
      institution of heparin therapy combined with coagulation factor replacement was
      followed by cessation of haemorrhage and complete recovery from acute renal
      failure.

PMID- 1033610
TI  - Ultrastructural aspects of ascosporulation in Arthroderma quadrifidum
      (=Trichophyton terrestre).
AB  - The ultrastructural features of developing and mature ascospores were delineated
      after mating Arthroderma quadrifidum on pablum cereal agar. Incipient ascospores
      each contained a granulated nucleus bounded by a nuclear envelope while
      presumptive ascospore cytoplasm was bounded by a double membrane and resided in
      glycogen-rich epiplasm of the ascus. Mature ascospores contained nuclei and
      mitochondria while the ascus epiplasm still retained abundant inclusions. The
      ascospore wall demonstrated the presence of heterogeneous material between the
      plasmalemma and the outer spore membrane which appeared smooth.

PMID- 1033611
TI  - The multifactorial/threshold concept -- uses and misuses.
AB  - The common congenital malformations have familial distributions that cannot be
      accounted for by simple Mendelian models, but can be explained in terms of a
      continuous variable, "liability," with a threshold value beyond which individuals
      will be affected. Both genetic and environmental factors determine liability,
      making the system multifactorial. Cleft palate is a useful experimental model,
      illustrating a number of factors that contribute to palate closure, the nature of
      a developmental threshold, and how genes and teratogens can alter the components
      of liability to increase the probability of cleft palate. The nature of the
      genetic component to liability in human malformations in not clear, and various
      possibilities, ranging from polygenic in the strict sense to a major gene with
      reduced penetrance are compatible with the data -- but the important feature is
      the threshold. Much of the confusion over the concept results from inconsistent
      use of terminology. The term "multifactorial" should be used for "determined by a
      combination of genetic and environmental factors," without reference to the
      nature of the genetic factor(s). "Polygenic" should be reserved for "a large
      number of genes, each with a small effect, acting additively." When several
      genes, with more major effects are involved, "multilocal" can be used. When it is
      not clear which of these is applicable the term "plurilocal" is suggested, in the
      sense of "genetic variation more complex than a simple Mendelian difference."
      Since teratological data often represent threshold characters the concept also
      has important implications for the interpretation of data on dose-response
      curves, synergisms, and strain differences in response to teratogens.

PMID- 1033612
TI  - Inhibition of pinocytosis in rat yolk sac by trypan blue.
AB  - Day 17.5 yolk sacs from rats injected with partially denatured 125I-labeled
      bovine serum albumin (I-BSA) were cultured in vitro by a raft technique. The
      rates of release of [125I]iodotyrosine were similar in control yolk sacs and in
      yolk sacs from rats preinjected with trypan blue. Day 17.5 rat yolk sacs were
      also cultured in medium containing I-BSA. Following pinocytic uptake the
      substrate was degraded intracellularly and [135I]iodotyrosine released into the
      medium. Trypan blue, when present in the medium in concentrations above 100
      mug/ml, inhibited pinocytosis of I-BSA and so decreased the rate of
      [125I]iodotyrosine production. Trypan blue similarly decreased the rate of
      pinocytic uptake of 125I-labeled polyvinylpyrrolidone. Pinocytic uptake of
      macromolecules was not decreased in yolk sacs from rats pretreated with trypan
      blue. The relevance of these results to the mechanism of teratogenic action of
      trypan blue is discussed. It is proposed that if trypan blue in teratogenic doses
      similarly inhibits pinocytosis by the yolk sac during the organogenetic period
      teratogenesis might result from a transient interruption in the flow of
      metabolites through the yolk sac to the embryo.

PMID- 1033613
TI  - Primary cardiac Kaposi's sarcoma.
AB  - We report the clinical, laboratory, and necropsy findings in a 14-year-old boy
      with a primary Kaposi's sarcoma of the heart. Primary cardiac Kaposi's sarcoma
      and angiosarcoma are compared, and the pathogenesis of Kaposi's sarcoma is
      discussed. Relevant literature is briefly reviewed.

PMID- 1033614
TI  - A teratogenicity study with amaranth in cats.

PMID- 1033615
TI  - The effect of LSD on the histology and ultrastructure of the neuroepithelium of
      young chick embryos: a stereological study.
AB  - Five control chick embryos and fifteen exposed to LSD at concentrations of 2.5,
      12.5 and 50 mug/ml were examined. The morphometric analysis performed at the
      light microscope level shows that (1) the section area of the neural tube
      increases with the two highest doses of lysergic acid diethylamide (LDS)
      employed, (2) the volume fraction of the intercellular spaces decreases with the
      two highest doses of LSD, (3) the volume fraction of the nuclei in the neural
      tube is not modified with any concentrations of LSD employed, (4) the volume
      fraction of the cytoplasm in the neural tube increases with all three
      concentrations, and (5) the nucleo-cytoplasmic ratio decreases with all three
      doses employed. Moreover, at the ultrastructural level, it was found that (1) the
      volume fraction of mitochondria in the cytoplasm decreases at doses of 12.5 and
      50 mug/ml (2) the surface to volume ratio of the mitochondria is unchanged with
      any of the concentrations of LSD employed and (3) the surface density of the
      endoplasmic reticulum in the cytoplasm increases only with a dose of 2.5 mug/ml
      of LSD.

PMID- 1033616
TI  - Use of a tissue sectioner to expose internal structures of biological samples for
      scanning electron microscopy.
AB  - A procedure yielding sections of unembedded biological samples for observation by
      scanning electron microscopy is described. Sections of samples, fixed and
      hardened in OsO4, were obtained in quantity with a tissue sectioner. Subsequent
      treatments to osmium-coat cut surfaces were employed prior to critical point
      drying. The procedure yields cleanly cut surfaces through cells and cytoplasmic
      organelles which are retained in their normal position. Sections of apple leaf
      and mouse kidney are illustrated. Sections can be readily cut in a desired plane
      with less structural damage than is typically encountered by other sectioning or
      dissection techniques.

PMID- 1033617
TI  - The use of frozen blood in neonatal exchange transfusion.
AB  - Because of inability to quickly locate donors to provide fresh heparinized blood,
      seven exchange transfusions were performed on four newborns with hemolytic
      disease due to Rhesus incompatibility using previously frozen erythrocytes
      suspended in albumin or heparinized, decitrated fresh frozen plasma. Platellets
      were added to one unit of previously frozen erythrocytes because of severe
      thrombocytopenia in one patient following an earlier exchange transfusion. The
      hematologic and bilirubin removing responses were comparable to those seen with
      fresh heparinized whole blood. Using this method, the safest red blood cells
      available, namely the mother's, can be drawn and frozen early in gestation for
      subsequent exchange transfusion.

PMID- 1033618
TI  - Incidence of fascioliasis in cattle slaughtered in Buachi (Nigeria).
AB  - A survey was carried out in Bauchi abattoir during the period March 1973 to
      February 1974 in order to estimate the incidence of bovine fascioliasis. A total
      of 14,270 cattle originating from various markets in North-eastern Nigeria were
      examined. The incidence rate varied considerably, the highest being recorded in
      cattle from markets adjacent to large floodplains. The overall incidence rate was
      31-7 per cent. The monthly incidence was highest during the periods immediately
      before and after the onset of the rains and was more a reflection of the
      marketing policy of the cattle owners than of the epizootiology of the disease.
      The annual loss in revenue caused by liver condemnations alone was estimated as
      19,375 Naira.

PMID- 1033619
TI  - [Sexual dysfunctions of emotional origin in women].

PMID- 1033620
TI  - [Treatment of female sexual disorders].

PMID- 1033621
TI  - Specific binding protein for 17 beta-estradiol in prostate with adenocarcinoma.
AB  - A specific binding protein for 17beta-estradiol has been detected in prostates of
      patients with prostatic adenocarcinoma, who had no endocrine manipulation prior
      to the removal of their prostates. Both the sucrose density gradient
      centrifugation and dextran-coated charcoal techniques were employed. The 17beta
      estradiol binding protein has an approximate sedimentation coefficient of 3.6S
      and is distinct from cystolic dihydrotestosterone binding protein.

PMID- 1033622
TI  - Delayed transection of urethra by mersilene tape.
AB  - This report is of a patient with complete urethral transection after undergoing a
      mersilene sling urethral suspension. This unusual complication eventually
      presented as anterior urethral pseudodiverticulum containing the mersilene tape
      with a secondary calculus.

PMID- 1033623
TI  - [Role of fungal flora in inflammatory ear diseases].

PMID- 1033624
TI  - Pyometra in a basset bitch.

PMID- 1033625
TI  - Genuine anoestrus in mares.

PMID- 1033626
TI  - The antibiotic sensitivity testing of pathogens commonly found in veterinary
      practice.

PMID- 1033627
TI  - Surgical treatment of Cushing's syndrome in the cat.

PMID- 1033628
TI  - Thelazia worms in the eyes of British cattle.

PMID- 1033629
TI  - [Our results in the treatment of testicular malignomas].

PMID- 1033630
TI  - [Intrauterine viral hepatitis].

PMID- 1033631
TI  - [Correlation of sex hormone levels with target tissue reaction in deficiency of
      the lutein phase of the menstrual cycle].

PMID- 1033632
TI  - [State of erythrokinetics in newborn infants born to mothers with anemia].

PMID- 1033633
TI  - [Role of heredity in the pathogenesis of idiopathic thrombocytopenic purpura in
      children].

PMID- 1033634
TI  - [Meteorotropic pathology of hemorrhagic diseases in childhood].

PMID- 1033635
TI  - [Importance of correction of water-electrolyte metabolism in the complex
      treatment of severe forms of late pregnancy toxemias].

PMID- 1033636
TI  - [Uterine hemodynamics in women during the postpartum period].

PMID- 1033637
TI  - [ Several clinico-physiologic features of the postpartum period in late toxemias
      of pregnancy].

PMID- 1033638
TI  - [Fractional composition of the RNA of mouse Krebs-II ascitic cell tumor and rat
      ovarian carcinoma].
AB  - Main fractions (28 S, 18 S and 4S RNA) of cytoplasmic and nuclear RNA were
      isolated preparatively from two variants of ascites tumor cells i. e. Krebs-11
      carcinoma in mice and ovarian tumor in rats. The method of analytical and
      preparative electrophoresis in 2.5% polyacryl amide gel has revealed a similarity
      in the spectrum of main fractions -- for c-RNA and n-RNA -- in both ascites
      tumors.

PMID- 1033639
TI  - [Case of human rabies].

PMID- 1033640
TI  - [ Somatostatin in insulin-dependent diabetics and in pancreatectomized patients
      (author's transl)].
AB  - The inhibitory effect of somatostatin on the secretion of glucagon permits the
      examination of the effect of glucagon on some metabolic parameters in the insulin
      dependent diabetic patient. The results obtained in 5 insulin-dependent diabetics
      and in 4 pancreatectomized patients revealed an inhibitory effect of somatostatin
      on blood glucose in the juvenile-type diabetics, but failed to show this
      influence of somatostatin in the pancreatectomized patients. These observations
      indicate a participation of glucagon in the generation of hyperglycaemia in
      diabetes mellitus. However, the failure of somatostatin to influence the blood
      glucose level in pancreatectomized patients contrasts with the results obtained
      in dogs and emphasizes the difficulty and pit falls in the application of animal
      experiments with somatostatin to humans.

PMID- 1033641
TI  - [World health statistics report].

PMID- 1033642
TI  - [Evaluation of some epidemiological factors in human toxoplasmosis].
AB  - The authors compared a group of 197 women with different ascertained forms of
      toxoplasmosis and a group of 72 women with negative serological reactions on
      toxoplasmosis and hereby they revealed that the consumption of insufficiently
      heated meats as well as the contact with animals (rearing and digestion
      embowelling or drawing of coat) play an eminent part. As test animals above all
      cats were used. The results of the two groups were compared and a significant
      difference between them was ascertained for the consumption of the insufficiently
      heated meat as well as for the contact with the animals. The women with
      toxoplasmosis more frequently consumed insufficiently heated meat and had more
      contact with cats and other animals.

PMID- 1033643
TI  - [Possibilities of erroneous interpretation of echocardiograms].
AB  - Diagnostic ultrasound is capable of providing important information on cardiac
      structures and motion. Diagnostic misinterpretations and errors, however, are not
      uncommon, due to the manner in which data are acquired and displayed during an
      echocardiographic examination. This paper discusses the typical echocardiographic
      patterns of a variety of important conditions concerning the mitral valve, the
      left ventricle, the interatrial and interventricular septum as well as the
      influence of respiration on the performance of echocardiograms. Essential
      pitfalls in establishing a correct diagnosis in each of these conditions are
      discussed and demonstrated by illustrations.

PMID- 1033644
TI  - Microfilaments in Naegleria fowleri amoebae.
AB  - Examination by electron microscopy has revealed 2 types of microfilament in the
      cytoplasm of 3 strains of axenically grown Naegleria fowleri amoebae. Thin, actin
      like microfilaments 5-7 nm in diameter are randomly oriented in the nonmotile
      amoebae, and are concentrated near the plasma membrane. In the actively motile
      amoebae these microfilaments aggregate to form colateral bundles in close
      proximity to the plasma membrane. Thick, myosin-like microfilaments 17-19 nm in
      diameter also occur in the amoebae cytoplasm. The significance of these 2 kinds
      of microfilament in amoeboid motion is discussed.

PMID- 1033645
TI  - [Vitellogenesis in Echeneibothrium beauchampi Euzet, 1959 (Cestoda:
      Tetraphyllidea, Phyllobothriidae) (author's transl)].
AB  - The vitellogenesis in Echeneibothrium beauchampi is studied by means of electron
      microscopy. In the follicles, the vitelline cells undergo three progressive
      changes characterized by cellular size, membrane system development and nature of
      stored inclusions. 1. Immature cells have a gonial morphology. 2. Maturing cells
      display a very well developed membrane system. Their cytoplasm is gradually
      filled with abundant lipid droplets. At the same time, a small number of
      homogeneous vesicles occur which contain protein material moderately electron
      dense. Glycogen (alpha and beta) appears at the end of the vitellogenesis. 3.
      Mature cells show a conspicuous regression of the membrane system. Cellular
      organelles, nucleus and protein vesicles are found in the peripheral cytoplasmic
      layer which still contains numerous free ribosomes. The amorphous remaining
      cytoplasm is filled with large amounts of aggregated lipid droplets which often
      surround glycogen areas. 4. The presence of numerous lipid droplets and glycogen
      in the vitelline cells of E. beauchampi shows evidence that this Tetraphyllidea
      is close to Pseudophyllidea, but the aspect of protein vesicles (shell-protein
      material) brings it near the Cyclophyllidea.

PMID- 1033646
TI  - [Sclero-atrophic dermatoses of the external genitalia in man].

PMID- 1033647
TI  - [Effect of cholinergic substances in experimental amnesia].

PMID- 1033648
TI  - [The effect of nicotine and amphetamine on the exploratory behavior of rats].
AB  - The effects of nicotine and amphetamine were found to be dependent on genetic
      variables. Nicotine produced a stimulant effect on exploratory behavior, while
      amphetamine produced stereotyped behavior patterns.

PMID- 1033649
TI  - [Heavy metal toxicity in mammalian cell cultures (author's transl)].
AB  - Static suspension cultures of L-A cells, a subline of L 929 mouse fibroblasts,
      were exposed to inorganic metal salts (chlorides). There was an increasing
      cytotoxicity from lead over mercury to cadmium as determined by reduction of
      viability and inhibition of proliferation. After 7 days' exposure the LD50 of
      lead was approximately 3 X 10(-4) M, of mercury 5 X 10(-5) M, and of cadmium 1.3
      X 10 (-5) M. The doses causing a 50% inhibition of increase in cell number (ID50)
      after 7 days' application were determined as follows: 4 X 10(-5) M for lead, 1.3
      X 10(-5) M for mercury, and 7.5 X 10(-6) M for cadmium. The biological effects of
      lead during chronic exposure were studied in more detail. Under continuous
      presence of the heavy metal the cells developed lead resistance, even to
      concentrations approaching the LD50. However, the proliferation rates of cells
      tolerating 1.4 X 10(-4) M were slightly, and of those tolerating 2 X 10(-4) M
      were clearly reduced as compared to the non-resistant (parent) cells. Cultivation
      of the resistant cells over 46 days (maximally 60 generations) in lead-free
      medium lead to a considerable loss of tolerance; this finding indicates that the
      induced lead resistance is caused by adaptation rather than by mutation and
      selection.

PMID- 1033650
TI  - [The interaction between cells and fibrous dusts (author's transl)].
AB  - The shape of fibrous dust particles is an important factor for the biological
      effects in cell cultures. The fibres elicit a special mechanism of incorporation
      which is dependent on their length and diameter but independent of their chemical
      composition. Fibres with a length less than 5 mum are phagocytized rapidly and
      completely by the cells, comparable to granular dust particles or milled fibres.
      Phagocytosis of long inorganic fibers is delayed and/or remains incomplete.
      Incomplete incorporation of the fiber causes a localized discontinuity in the
      cell membrane. There results continuous liberation of intra-cellular enzymes,
      which is compensated by an increasing glycolytic metabolism. The interaction
      between cell and fibre means a chronic irritation which is discussed as a factor
      in tumour induction. Fibrous dusts, e.g. asbestos and glass fibers, induce the
      formation of polykaryotic giant cells by way of fusion; asbestos possibly also
      causes the interspecific fusion of cells. There are indications that in the
      process of asbestos-induced cell fusion integrated virus genomes are activated
      and infectious viruses are released. There seems to be a causal relationship
      between the fibrogenic and carcinogenic effects of inorganic dusts and their
      shape, i.e. their length and diameter, regardless of their chemical composition.
      Thus the fibrogenic and carcinogenic effect is limited by a minimal length and a
      maximal diameter. The findings are discussed with regard to the air burden of
      fibrous dusts and their implications for human health.

PMID- 1033651
TI  - [Electrophysiological study of the central nervous system of female rats in the
      dynamics of development of ovarian polycystosis].

PMID- 1033652
TI  - Influence of x-rays on diurnal viration in 131I uptake by guinea pig thyroid.
AB  - The 131I uptake by guinea pig thyroid is subject to distinct diurnal variation.
      In control males, peak values occurred at 12 h, and minima at 24 h. In control
      females, peak values were also at 12 h, but minima at 6 h. In guinea pigs
      irradiated with 500 R of X-rays, a rise in 131I uptake began 1 h after
      termination of irradiation in both sexes and at all intervals, but maximum and
      minimum values were at the same time as in controls.

PMID- 1033653
TI  - [The effect of potentiating factors on the bradykinine effect in vitro].
AB  - Bradykinin potentiating factors from the venom of Bothrops jajaraca and
      Agkistrodon halys blomhoffii potentiate the action of bradykinin at several
      smooth muscles. This potentiation is specific for bradykinin and has to be
      distinguished from an unspecific potentiation. The potentiation induced by BPF is
      not due to an indirect cholinergic mechanism or to a kininase inhibition in
      vitro. The results suggest that there would be an allosteric transition of the
      bradykinin receptor.

PMID- 1033654
TI  - [Injuries of the pelvic bone and lower urinary pathways].
AB  - We are all witness of the rapid tempo of our life styles made possible by recent
      advances in modern technology. The powerful, fast automobiles used in our society
      are an important contributing factor in trauma and polytrauma. Etiology of
      injuries therefore are changing before our eyes. Based on statistics of the
      hospital taken on a series of 753 polytraumatized cases during 1961--1967, the
      most common etiological factor was automobile accidents. According to predictions
      for 1977, in Serbia there will be 70,000--105,000 injuries resulting from
      automobile accidents. 7,000 of these injuries will result in death, 36,000 will
      be severe injuries, and 62,000 will be minor injuries. These are frightening
      statistics, and further comment is not needed. Until recently, the principle
      cause of pelvic trauma was falling from high heights. However, today, statistics
      show that 60%--80% of all pelvic fractures occur in automobile accidents, only
      19% are caused by falls, and 6.4% by industrial accidents. This illustrates the
      trastic change in etiology of fractures of the pelvis and trauma of the lower
      urinary pathways.

PMID- 1033655
TI  - [First clinical experiences with scintiphotosplenoportography].
AB  - This paper reports on the clinical applicability and efficiency of
      Scintiphotosplenoportography (SPSP) by means of 99mTc Pertechnetate. This
      diagnostic process permits obtaining the following data: actual route and patency
      of the portal vein, localizing of collaterals, as well as information on the
      actual speed of portal flow. By determining the time of transit of the
      radionuclid via the collateral pathways into systemic circulation, additional
      assessments as to the hemodynamic functional importance of these collaterals can
      be made. This process is of particular value for the speedy assessment of the
      patency of a surgically effected portocaval shunt in cases of shunt-bleeders. In
      patients without cirrhosis, a stop in the filling along the course of the portal
      vein indicates portal thrombosis. In cases of manifest cirrhosis, however, the
      lack of an SPSP image for the proximal portal vein and the liver itself, merely
      points to the existence of extensive caudal collaterals. Traumatization as the
      result of intrasplenal application of a volume of less than 1 ml (of tracer)
      remains minimal. In contrast with radiological splenoportography this methods
      entails practically no risks. However, as a result of the restricted field of
      view and the relatively coarse power of resolution, the quality obtainable by
      szintiphotosplenoportography is somewhat inferior to that of X-ray
      splenoportography.

PMID- 1033656
TI  - [Duplication of the superior caval veins--an autopsy case].

PMID- 1033657
TI  - Latent vaginal choriocarcinoma in a postmenopausal woman.
AB  - A 50-year-old Japanese female with choriocarcinoma showed three unusual features:
      the primary tumor developed in the vagina ectopically without uterine lesion; the
      first symptoms of atypical vaginal bleeding and coughing occurred 23 years after
      the last pregnancy; and the tumor appeared during postmenopause. The possible
      mechanisms for the ectopic location and latency are discussed.

PMID- 1033658
TI  - Intracellular cysts in gastric carcinoma.
AB  - Intracellular cysts were often found in the tumour cells in gastric carcinomas of
      intestinal as well as diffuse type in specimens from stomachs resected for
      gastric cancer. In the light microscope, the cysts appeared usually as solitary
      cytoplasmic vacuoles. In the electron microscope, the intracellular cysts were
      seen as round cavities, often containing homogenous or granular mucous material
      which stained with the periodic acid-silver methenamine (PASM)-method. Relatively
      long microvilli were lining the cysts and, not infrequently, abundant cytoplasmic
      microfilaments would surround the cyst wall. Similar cysts have been observed in
      a number of other tumours and, accordingly, their diagnostic significance must be
      considered in connection with other methods such as differential staining of
      cellular mucosubstances.

PMID- 1033659
TI  - Precipitins in Liberian sera reacting with goat and sheep sera.
AB  - Precipitins in nine sera from normal Liberian adults were shown to react with an
      alpha-globulin in goat and sheep sera. No cross-reaction was demonstrated with
      bovine sera. Hence these precipitins are different to others previously
      described. At present their significance, if any, is unknown. They are important
      as a possible cause of unexplained reactions in serological tests using sheep or
      goat serum as a source of antigen or antibody.

PMID- 1033660
TI  - Biosynthesis of cephalosporins.

PMID- 1033661
TI  - Novel transformations of prostaglandin endoperoxides: formation of thromboxanes.

PMID- 1033662
TI  - Prostaglandin biosynthesis: consequences of oxygenase mechanism upon in vitro
      assays of drug effectiveness.

PMID- 1033663
TI  - Reducing patient exposure to ionizing radiation--is it really necessary?
AB  - The thesis that medical radiation exposures to the general population in the
      United States are excessive and that urgent steps need to be taken to reduce them
      is examined. At the present time, no evidence is found that deleterious effects
      result from radiation exposures at the level of a few rads or less. Nevertheless
      it is prudent that we assume the possibility of harmful effects of radiation
      exposure. However, because medical radiology is clearly so beneficial, and the
      harmful effects are problematical, it is doubtful whether the public should be
      alarmed by the suggestion of any crisis. A balancing of risks and benefits in the
      medical uses of radiology supports this latter contention.

PMID- 1033664
TI  - The fate of folate polyglutamates in meat during storage and processing.
AB  - The rate of hydrolysis of chicken liver folate polyglutamates, by endogenous
      liver conjugases, under various conditions of storage, heat, and tissue
      disruption, were investigated. The procedure used was to allow a radioactive
      tracer dose of the vitamin to equilibrate into the folate polyglutamyl pool.
      After various storage periods and treatments the polyglutamyl state of the folate
      present was examined by analytical techniques based on oxidative degradation of
      native folate polyglutamates to the corresponding p-aminobenzoylpolyglutamate
      followed by chromatographic separation on DEAE cellulose anion exchange resin.
      Identification of folate polyglutamates present was made by simultaneous elution
      of known p-aminobenzoylpolyglutamate markers. In an intact tissue sample only
      slight degradation was found after 48 hr at 4 C; complete degradation of folate
      polyglutamates taking 120 hr. Samples of homogenized tissue show complete
      degradation to folate monoglutamates and a small amount of diglutamate after 48
      hr storage. Superimposed on the above is the consideration that if at any time
      prior to or during storage the liver is heated to greater than 100 C irreversible
      inactivation of the endogenous conjugases takes place and the folate
      polyglutamate pattern is stabilized. It was also demonstrated that during two
      different heating procedures no extra deconjugation occurred.

PMID- 1033665
TI  - ABO hemolytic disease of the newborn, without hyperbilirubinemia.
AB  - ABO hemolytic disease of the newborn without hyperbilirubinemia is described in
      17 full-term infants. The erythrocyte characteristics, such as reticulocytosis,
      microspherocytosis, and positive indirect antiglobulin (Coomb's) test, resembled
      those in ABO disease with hyperbilirubinemia. Erythrocyte acetylcholinesterase
      activity was reduced in this group to the same degree as in the more severely
      affected infants. Negro infants predominated over white, in a 2.5:1 ratio in this
      mild ABO group.

PMID- 1033666
TI  - Obstetrician-gynecologists are primary physicians to women.
AB  - Our studies of the practice patterns of Michigan obstetrician-gynecologists
      indicate that they serve in a dual capacity: that of primary physicians to women
      and that of specialist obstetrician-gynecologists. They provide a considerable
      amount of general medical care for their own patients in the former role, and
      traditional specialist services for their own patients and for those referred by
      other physicians in the latter. The objectives and educational content of most
      house officer training programs do not reflect these changes. Training is
      directed almost exclusively toward preparing residents for specialty practice and
      often does not offer them basic experience and permit them to develop basic
      skills in other disciplines, notably internal medicine nad psychiatry, which they
      will need to practice as parimary physicians to women. An educational program
      designed to prepare residents more broadly for what they will actually be doing
      in practice without compromising their training as specialists is described.

PMID- 1033667
TI  - The embryologic development of the human vagina.
AB  - Our present understanding of the sequence and mechanisms of human genital
      organogenesis is reviewed. Current theories about the derivation of the vaginal
      epithelium are examined and tested against two anomalous circumstances,
      congenital androgen insensitivity and agenesis of the lower vagina, which are
      presented as examples demonstrating the respective participation of the
      urogenital sinus or of the Mullerian ducts alone in the developmental process.
      The abnormalities recently described in the vagina and cervix of girls exposed in
      utero to diethylstilbestrol (DES) correspond remarkably with those encountered in
      lower vaginal agenesis, particularly with regard to the presence of vaginal
      adenosis, the deficiency of glycogen in the squamous cells (squamous metaplasia),
      and the abnormal response of the squamous epithelium to Schiller's iodine test.
      It is concluded that the development of the human vagina is best explained by the
      theory which holds that the Mullerian ducts in fetal life extend caudally to the
      level of the future hymen. After fusion of these ducts, squamous cells arising in
      the epithelium of the urogenital sinus invade from below, advance, and replace
      completely the Mullerian mucosa up to the level of the external os of the
      cervical canal.

PMID- 1033668
TI  - Management and outcome of pregnancies associated with the Copper T intrauterine
      contraceptive device.
AB  - The clinical outcome of 918 pregnancies in women who conceived while using one or
      another of four models of the Copper T intrauterine contraceptive device (IUD) is
      presented. Elective abortion was chosen by 58 per cent of the women. The clinical
      management and course of 275 women who elected to allow their unplanned pregnancy
      to continue are described. The Copper T was either expelled or extracted during
      the pregnancy in 118 of the women, while the IUD remained in situ for the
      duration of the pregnancy in the remaining 157 patients. The incidence of
      spontaneous abortion more than doubled when the IUD remained in utero. The chance
      of a live birth being premature was four times greater when the IUD remained in
      situ than when it was removed. There were 27 ectopic pregnancies in this entire
      series, giving an incidence of 3.4 per cent. In addition, the data suggest, but
      do not prove, that there is an increased risk of having an ectopic pregnancy if
      the woman has worn the Copper T for more than two years. A benign fibroma of the
      vocal cord was the only congenital anomaly detected. These observations suggest
      that the incidence of developmental defects is not adversely affected by the
      presence of intrauterine copper.

PMID- 1033669
TI  - True hermaphroditism: an analytic review with a report of 3 new cases.
AB  - Three new cases of true hermaphroditism are described: a 14-year-old patient with
      a testis on one side and an ovotestis on the other side and a 11-year-old patient
      as well as a 6-year-old patient both with an ovary on the one side and an
      ovotestis on the other side. Twenty-four cases, which were personally
      investigated, were previously reported. Therefore, this analytic review is based
      upon the author's experience of 27 cases as well as 340 cases reported in the
      world literature since 1899. The presenting symptoms and age of diagnosis are
      discussed. Apart from ambiguous genitals, the development of breasts in a patient
      reared as male is an important presenting symptom. The variations found regarding
      the external and internal genitals are described. An ovotestis is the most common
      gonad found in true hermaphroditism. Among 116 ovotestes available for analysis,
      46 per cent are located in an ovarian position, 26 per cent in the labioscrotal
      fold, 24 per cent in the inguinal canal, and 4 per cent in the internal inguinal
      ring. Evidence of ovulation is found in 50 per cent of ovotestes. Spermatogenesis
      has not been observed in the testicular portion of an ovotestis. Spermatogenesis
      was present in only 12 per cent of testes found in true hermaphroditism.
      Dysgerminomas occur with a frequency of 1.3 per cent. A fallopian tube and a vas
      deferens were never found together next to an ovotestis. Cytogenetic findings are
      reported in 115 cases of true hermaphroditism, including the cases described in
      this paper. A 46,XX chromosomal complement is the most common finding, occurring
      in 57.4 per cent of cases. It is interesting that 42.6 per cent showed no
      evidence of a Y chromosome. With the use of the fluorescent technique in
      metaphase chromosomes as well as the Y chromatin body in interphase cells, no Y
      chromosome was detected in the three new cases reported here. The various
      possibilities for the development of testicular tissues in the absence of a Y
      chromosome are discussed. In the diagnosis of true hermaphroditism the palpation
      of an ovotestis with a soft testicular portion and a firm ovarian portion is
      stressed. As far as the treatment of true hermaphroditism is concerned, the
      external genitals should be changed according to the gender identity which
      usually correlates with the sex of rearing.

PMID- 1033670
TI  - The effects of dexamethasone on plasma free androgens during the normal menstrual
      cycle.
AB  - In order to evaluate the ovarian and adrenal contribution to peripheral plasma
      concentrations of total testosterone (TTe), indixes of the plasma concentrations
      of free testosterone (FTeI), free 17 beta-hydroxysteroid androgens (FHSI), and
      testosterone-binding globulin (TeBG) during the menstrual cycle, women were
      examined during three normal cycles and three other cycles under dexamethasone
      (0.5 mg., four times a day) suppression. All study cycles were apparently
      ovulatory. The mean TTe and FTeI during the midcycle period were significantly
      higher than during the early follicular (P less than 0.005) and the midluteal
      periods (P less than 0.01 and P less than 0.001, respectively). During the
      menstrual cycles under dexamethasone suppression only the difference in TTe and
      FTeI between the midcycle (37 +/- 12.4 (S.D.) ng. per 100 ml. and 10.5 +/- 4.0
      (S.D.), respectively) and the midluteal (26.0 +/- 10.1 (S.D.) ng. per 100 ml and
      7.2 +/- 3.2 (S.D.), respectively) periods was significant statistically (P less
      than 0.05). No significant differences in the mean levels of FHSI and TeBG
      between three periods within the cycle were noted in either the control or the
      dexamethasone-treated cycle. When each phase was compared, the mean levels of
      TTe, FTel, and FSHI were significantly lower in the dexamethasone-treated cycles
      than in the normal cycles. The data suggest that the level of TeBG is not
      perceptibly affected by physiologic fluctuation of estrogen levels during the
      menstrual cycle, and the FHSI levels are stable throughout the ovulatory cycle.
      Decrease in levels of TTe, FTeI, and FHSI during dexamethasone suppression seems
      to be due to reduction of androgen production as TeBG, a major determinant of the
      metabolic clearance rate of androgens, was not affected by dexamethasone.

PMID- 1033671
TI  - Diagnosis of prolactin-secreting pituitary microadenoma.
AB  - Four women with secondary amenorrhea associated with hyperprolactinemia were
      studied. Baseline hormonal evaluation, including serum FSH, serum LH, TSH, T3,
      T4, and plasma cortisols were normal. Plain sella turcia x-rays were also normal.
      Prolactin-secreting pituitary microadenomas were found in all of the patients
      only after further diagnostic studies were done. These studies included
      polytomography of the sella turcia, dynamic pituitary testing of growth hormone
      reserve, ACTH reserve, gonadotropin reserve, and prolactin suppression with L
      dopa. The early diagnosis of a small prolactin-secreting adenoma may be possible
      if several diagnostic criteria are ulilized. The most sensitive techniques
      available are: (1) polytomography, (2) the magnitude of plasma prolactin
      evaluation, and (3) the failure of suppression of prolactin secretion with L
      dopa. Our findings emphasize the importance of an extensive evaluation of all
      women with amenorrhea associated with hyperprolactinemia.

PMID- 1033672
TI  - Techniques of argon laser photocoagulation of diabetic disk new vessels.
AB  - Four argon laser techniques have been evaluated in the eradication of diabetic
      disk neovascularization: focal (nonfeeder) photocoagulation, feeder-frond
      photocoagulation alone, panretinal photocoagulation alone, and feeder-frond
      treatment combined with panretinal photocoagulation. Focal photocoagulation was
      dangerous and the least effective technique in preventing recurrence of
      neovascularization. Feeder-frond photocoagulation was effective initially, but
      was associated with a high incidence of recurrent neovascularization. Panretinal
      photocoagulation and panretinal photocoagulation combined with feeder-frond
      treatment produced results superior to those obtained with the two earlier
      techniques. The best results were obtained with combined feeder-frond and
      panretinal photocoagulation done concurrently. Early diagnosis, aggressive
      photocoagulation therapy, and close follow-up were essential in order to obtain
      good results.

PMID- 1033673
TI  - Night myopia: cause and a possible basis for amelioration.
AB  - The relationship between night myopia under simulated night driving conditions
      and the dark focus accomodation was examined. Over a range of luminance and
      contrast conditions typical of the night driving situation, college-age subjects
      accommodated to about one-half the difference between a distant simulated road
      sign and their individual dark focus. Subsequent laboratory and field experiments
      demonstrated that: (1) a negative correction equal to one-half the value of the
      dark focus significantly improved night visual performance as compared with their
      normal or full dark-focus correction, and (2) greater improvements in performance
      were obtained for subjects who exhibited a relatively near dark focus.

PMID- 1033674
TI  - Eye movement patterns and reading performance in poor readers: immediate effects
      of convex lenses indicated by book retinoscopy.
AB  - Eye movement patterns and reading performance were evaluated in 38 4th and 5th
      grade male students who were at least 1 year behind in their reading levels. Half
      of the subjects (Group I) demonstrated a need for convex lenses at near by a book
      retinoscopy criterion. The remaining subjects (Group II) showed no need for
      convex lenses at near by the same criterion. The subject's eye movements during
      reading were recorded by a commercial device called Eye-Trac. These recordings
      were made with 2 lens applications, plano and +0.50 D, respectively. The number
      of fixations, regressions, rate of reading, and relative efficiency for each
      condition (plano and +0.50 D) were calculated. In Group I, 3 of 5 measures showed
      significant improvement with plus lenses. These subjects showed fewer
      regressions, increased reading speed, and higher relative efficiency with plus
      than without. In Group II, 3 of 5 measures showed decrement with plus lenses,
      while 1 (comprehension) showed improvement. These subjects showed more fixations
      and regressions and lower relative efficiency with plus than without. It is
      therefore concluded that convex lenses of low power can have considerable
      immediate effect on children's reading skills, sometimes helpful and sometimes
      detrimental, and that proper pretesting with both retinoscopy will aid in the
      prediction of this effect.

PMID- 1033675
TI  - [Effect of prostaglandin F2alpha and oxytocin on the acetylcholine-
      cholinesterase system in uterine inertia].

PMID- 1033676
TI  - [Difficulties in the diagnosis of several forms of tubal pregnancy and ways of
      overcoming them (a propos the article by N. V. Kobozeva and A. V. Gur'eva
      "Progesterone test as a method of diagnosing tubal pregnancy")].

PMID- 1033677
TI  - [Fertility, pregnancy and labor in patients with Sheehan's syndrome].

PMID- 1033678
TI  - [Ovarian cyst during pregnancy].

PMID- 1033679
TI  - [Increase in weight of the human placenta].

PMID- 1033680
TI  - [Serum protein and lipoprotein levels in experimentally induced small for age
      rats].

PMID- 1033681
TI  - [Boundary between the squamous and cylindrical epithelium in the region of the
      external os of the cervical canal in full term and premature newborns and in
      young and prepuberal girls (I)].

PMID- 1033682
TI  - [Boundary between the squamous and cylindrical epithelium in the region of the
      external os of the cervical canal in full term and premature newborns and in
      young and prepuberal girls (II)].

PMID- 1033683
TI  - [Therapeutic activity of catleukocyte interferon in the treatment of viral
      diseases of the genitclia and several aspects of the body's resistance of
      malignization].

PMID- 1033685
TI  - A simple method for studying steroid--antibody interaction under conditions of
      thermodynamic equilibrium.

PMID- 1033686
TI  - Fractionation of RNA polymerase subspecies from soybean hypocotyls by isoelectric
      focusing in sephadex.

PMID- 1033687
TI  - Characterization of steroid-binding macromolecules in small biological samples by
      a rapid minigel filtration method.

PMID- 1033688
TI  - Cold-vapor atomic absorption spectrometric determination of nanogram amounts of
      organic mercury in sediments or aquatic organisms.

PMID- 1033689
TI  - Arterial and venous plasma levels of bupivacaine following peripheral nerve
      blocks.
AB  - Mean arterial plasma (MAP) and peripheral mean venous plasma (MVP) levels of
      bupivacaine were ascertained in 3 groups of 10 patients each for: (1) intercostal
      nerve block, 400 mg; (2) block of the sciatic, femoral, and lateral femoral
      cutaneous nerves, with or without block of the obturator nerve, 400 mg; and (3)
      supraclavicular brachial plexus block, 300 mg. MAP levels were consistently
      higher than simultaneously sampled MVP levels, the highest levels occurring from
      bilateral intercostal nerve block. No evidence of systemic toxicity was observed.
      The results suggest that bupivacaine has a much wider margin of safety in humans
      than is now stated.

PMID- 1033690
TI  - Ketamine and intraocular pressure in children.
AB  - The effect of ketamine on intraocular pressure (IOP) was studied in 10 children.
      Control IOP values were determined prior to induction of anesthesia, following
      premedication with atropine alone or in combination with pentobarbital and
      meperidine. After the IM injection of 8 mg/kg of ketamine, the IOP was determined
      at 5, 10, 15, and 20 minutes. Mean (+/- SD) IOP values before and after ketamine
      were 22.2 +/- 4.8 and 16.7 +/- 3.3 torr (p less than 0.001), respectively. The
      authors believe that the reduction in IOP was not due to ketamine, per se, but
      rather to lack of patient relaxation and cooperation during control measurements.
      At the end of 20 minutes, a second dose of ketamine, this time 1 mg/kg IV, was
      given and measurements were repeated at the same intervals. In 5 patients, the
      effects on IOP of d-tubocurarine, endotracheal intubation, and N2O inhalation
      also was evaluated. A significant increase (6.7 torr) in IOP was observed only
      after endotracheal intubation. The authors conclude that ketamine does not raise
      IOP in the healthy pediatric patient and, therefore, can be used for ophthalmic
      procedures requiring sedation or anesthesia.

PMID- 1033691
TI  - Anesthesia and the modification of response to infection in mice.
AB  - Anesthetic-induced immunosuppression, if clinically significant, could modify the
      natural course of infectious disease in vivo. To test this bypothesis, the
      localized response to IM Candida albicans and the mortality following fecal
      peritonitis were examined in anesthetized mice. Using these 2 models, halothane
      anesthesia was found not to modify the natural history of local sepsis but to
      significantly accentuate the mortality associated with the more severe infection.
      Possible explanations for these results include significant inhibition of
      reticuloendothelial function or plasma opsonization with relatively minor
      derangements of peripheral leukocyte capability.

PMID- 1033692
TI  - The effects of stellate ganglion block on the idiopathic prolongation of the Q-T
      interval with cardiac arrhythmia (the Romano-Ward syndrome).
AB  - The association of a prolonged Q-T interval, congenital deafness, and syncopal
      attacks due to ventricular fibrillation following emotional or physical stress is
      known as the Jervell-Lange-Nielsen syndrome. Absence of the congenital deafness
      characterizes the otherwise identical Romano-Ward syndrome. Both conditions have
      a high mortality rate and are recognized as contributing to sudden death in
      children. Although the pathogenetic factors are not yet completely elucidated,
      the condition is well enough understood to permit effective treatment. The
      authors performed a left stellate ganglion block in a 12-year-old girl with a
      mild form of the Romano-Ward syndrome, shortening the Q-T interval and
      eliminating the ventricular tachyarrhythmia. The left stellete ganglion block
      should be considered by anesthesiologists as an emergency measure, effective in
      interrupting the attack.

PMID- 1033693
TI  - The development of an acute tolerance to ketamine.
AB  - A rapidly developing tolerance to the hypnotic effect of ketamine in rats and
      mice has been investigated. On the basis of plasma and brain concentrations of
      ketamine at the time the animals wakened, it seemed likely that a central nervous
      system tolerance to the drug explained the shortened sleeping times noted.

PMID- 1033694
TI  - Isoenzymes of creatine phosphokinase in serum of families with malignant
      hyperpyrexia.
AB  - The activity and isoenzymes of creatine phosphokinase (CPK) in the serum of 2
      women vulnerable to malignant hyperpyrexia were studied. Serum CPK activity was
      markedly elevated but, in contrast to a previous report, only skeletal-muscle
      type CPK activity was present.

PMID- 1033695
TI  - Naloxone antagonism after narcotic-supplemented anesthesia.
AB  - Narcotic-supplemented balanced anesthesia is increasing in popularity; however,
      the narcotic must frequently be antagonized postoperatively. Authorities differ
      in their recommendations as to dose and as to mode and duration of administration
      of the narcotic antagonist. In the present study of 58 patients undergoing
      narcotic-supplemented anesthesia, 60 percent of 42 fentanyl patients and 81
      percent of 16 morphine patients required postsurgical naloxone for respiratory
      inadequacy. Naloxone dosage was initially 1.5 mug/kg IV, with repeat IV doses of
      1.5 mug/kg, when needed, at 3-minute intervals, until a regular respiratory rate
      greater than 15 breaths/min was attained. None of the fentanyl patients and only
      25 percent (4/16) of the morphine patients required additional naloxone in the
      recovery room. For the latter, the dose of naloxone previously administered was
      given IM and proved satisfactory. Additional analgesia was needed by 12 percent
      (7/58) of the patients during the recovery room stay. Judicious naloxone
      titration permitted respiratory adequacy to coexist with analgesia after narcotic
      supplemented anesthesia.

PMID- 1033696
TI  - Enflurane as a primary anesthetic agent for patients with chronic obstructive
      pulmonary disease.
AB  - For years, halothane has been the anesthetic agent of choice for patients with
      chronic obstructive pulmonary disease (COPD) and reversible airway disease
      (asthma). Enflurane was compared with halothane in 100 patients with COPD
      substantiated by spirometry and history. Intraoperative and postoperative
      complications in each relatively homogenous 50-patient group were assessed.
      Spirometry, blood gases, chest x-rays, incidence of complications involving
      secretions, coughing, wheezing, and cardiovascular problems were similar in both
      groups. Enflurane appears to be equivalent to halothane as an anesthetic in such
      patients.

PMID- 1033697
TI  - Unexpected hepatic dysfunction found by multiple laboratory screening.
AB  - During a 1-year period, 7620 elective surgical admissions were given multiple
      laboratory screening (SMA-18) determinations. Of these, 11 healthy patients, aged
      10 to 54, with a pretest classification of ASA 1 (no systemic disease) were found
      to have clearly abnormal elevations of the SGOT, SGPT, and LDH levels. The
      proposed elective surgical procedures and anesthesia were canceled. All 11
      patients proved to have overt liver pathology by further testing, and 3 later
      became clinically jaundiced. No cases of unexplained postsurgical jaundice
      occurred in any of the other 7609 operated cases during the 1-year study. The
      incidence of clearly elevated enzyme levels in voluntary hospital surgical
      admissions is approximately 1/700 and the incidence of clinical jaundice is
      approximately 1/2540. There appears to be a seasonal variation, with the
      preponderance of elevated enzyme levels in the winter and spring months.

PMID- 1033698
TI  - Postpartum hypertension and convulsion after oxytocic drugs.
AB  - An 18-year-old primipara developed acute hypertension leading to cerebral edema
      and convulsions following the IV injection of a bolus of 10 units of oxytocin
      with 0.2 mg methylergonovine maleate. Oxytocin in a dose of more than 2 units
      should not be administered IV in a single injection, as severe hypotension may
      result. If oxytocin is required, it can be injected either IM, or by IV pump or
      drip. The use of ergot in obstetrics should be limited to the treatment of life
      threatening postpartum hemorrhage and be given only by the IM route. Ergot should
      not be administered to patients with cardiac, renal, or hypertensive disease, or
      in association with a vasoconstrictor.

PMID- 1033699
TI  - A simple technic to minimize tracheal aspiration.

PMID- 1033700
TI  - The anesthetic potency of lidocaine in the rat.
AB  - The anesthetic effect of lidocaine was evaluated in rats by determining the
      change in anesthetic requirement of cyclopropane MAC that was produced by blood
      concentrations of lidocaine in the clinically useful range. A linear reduction in
      anesthetic requirement was produced with concentrations up to 1 mug/ml. Further
      increases in lidocaine up to 5.5 mug/ml resulted in no further decrease in
      cyclopropane requirement. Lidocaine was found to contribute a maximum MAC
      fraction of 0.4.

PMID- 1033701
TI  - Early reversal of postoperative hypoxemia.
AB  - Peridural analgesia was combined with the respiratory-stimulant effect of
      doxapram for intermittent hyperinflation of the lungs to reverse early
      postoperative (PO) hypoxemia following inhalation anesthesia for upper abdominal
      operations. Twenty unpremedicated men undergoing upper abdominal operations were
      studied for 5 hours in the recovery room. Ten of these patients received doxapram
      plus peridural analgesia; the other 10, doxapram plus morphine analgesia. Rectal
      temperature, PaO2, PaCO2, respiratory rate, exhaled minute ventilation (VE),
      tidal volume (VT), and blood pressure and pulse were measured. The mean increase
      from control for VE was 9.6 L/min and for VT, 356 ml/breath during doxapram
      therapy for the morphine group. Corresponding values for the peridural group were
      14.4 L/min for VE and 660 ml/breath for VT. Mean PaO2 for the morphine group
      decreased significantly from the corresponding preoperative value (p less than
      0.005). Lack of significant change between preoperative and PO values for PaO2
      for the peridural group would indicate that under the conditions of this study,
      early PO hypoxemia can be reversed by the combination of peridural analgesia with
      doxapram therapy.

PMID- 1033702
TI  - Local anesthetic agents--pharmacologic basis for use in obstetrics: a review.
AB  - Because of the minimal effects on mother and fetus, regional anesthetic technics
      are widely employed for labor and delivery. However, the literature describes at
      least 35 fetal and neonatal deaths and a frightening incidence of fetal distress
      associated with paracervical block for 1st-stage labor. Continuous lumbar
      epidural anesthesia for 1st-stage labor has also been associated with fetal
      distress, but this is minimal and no deaths have been reported. Bupivacaine, a
      relatively new, long-lasting local anesthetic, is extemely toxic when
      administered paracervically, but no deaths have been reported with its use for
      epidural anesthesia. While choice of method and agent must be individualized,
      continuous lumbar epidural block with bupivacaine appears as effective as and
      less often dangerous to the fetus than paracervical block.

PMID- 1033703
TI  - Obstetric anesthesia training centers in the U.S.A.--1975.
AB  - The current status of obstetric anesthesia training in the United States is
      reviewed. The 39 anesthesia residency training programs having full time chiefs
      of obstetric anesthesia were surveyed regarding clinical practice, physical
      facilities, teaching and research. This paper reports the results and compares
      them to recommendations of JCAH, ACOG and ASA, concerning standards of patient
      care and resident teaching.

PMID- 1033704
TI  - Statistical pearls. III. The most likely interpretation.

PMID- 1033705
TI  - Uptake and excretion of 1-bromo-1,2,2-Trifluorocyclobutane (42M-9) in man:
      comparative study on pharmacokinetics and metabolism of inhalation anesthetics.
AB  - 1-bromo-1,2,2-trifluorocyclobutane (42M-9) has physical properties similar to
      those of methoxyflurane and has been suggested for use as an anesthetic agent.
      Its MAC value, predicted from its lipid solubility, is 0.26 percent. No
      clinically significant changes were observed in cardiovascular or respiratory
      function or in clinical laboratory tests. Ventricular dysrhythmias were not seen
      in this study at analgesic concentrations in contrast to those reported at
      anesthetic concentrations by others. Pulmonary uptake was high and wash-out was
      slow. The total amount exhaled comprised 60 percent of the dose. Fluorine,
      equivalent to 11 percent of total uptake, was rapidly excreted in urine as
      nonvolatile fluorinated metabolites. An additional 9 percent of 42M-9 was
      degraded to fluroide and excreted in urine. Since an amount of fluoride
      equivalent to that excreted in the urine tends to be deposited in the skeleton,
      approximately 29 percent of uptake may possibly be accounted for as metabolites.
      Based on fluorine recovery, the fate of 11 percent of 42M-9 uptake remains
      unknown. The kinetics of uptake, metabolism and excretion of 42M-9 did not differ
      significantly over a five-fold change of inspired concentration. A comparison of
      the pulmonary clearance of unaltered 42M-9 and the fraction of uptake converted
      to urinary metabolites or unrecovered with those of other volatile halogenated
      anesthetics and their physical properties supports the conclusion that 42M-9 is
      relatively resistant to biotransformation.

PMID- 1033706
TI  - Crdiovascular effects of lidocaine during acid-base imbalance.
AB  - Although lidocaine HCl is often given to critically ill patients with ventricular
      tachyarrhythmias, it use is not without hazard. To investigate whether acid-base
      disturbances and their subsequent effects on molecular ioization influence
      cardiovascular (CV) response to lidocaine, dogs in normal acid-base balance,
      metabolic acidosis, respiratory acidosis, and respiratory alkalosis were given 2
      or 4 mg/kg lidocaine IV. Heart rate (HR), PR and QT intervals, MAP, LVEDP, LV
      dp/dt, and LV dp/dt divided by CPIP were measured at intervals. In all groups a
      slight increase in mean HR occurred after 2 mg/kg. Generally, myocardial
      contractile force was depressed in direct proportion to dose. Essentially, the CV
      response to lidocaine was not altered by any clinically remarkable degree by pH
      disturbances. Responses differing from those observed during normal acid-base
      conditions could not be significantly correlated with changes in pH or PaCO2.
      Results suggest that, in the intact animal, the CV effects of lidocaine,
      administered in therapeutic doses, are not appreciably influenced by clinically
      encountered states of acid-base imbalance.

PMID- 1033708
TI  - Difficult extubation of an endotracheal tube cuff.

PMID- 1033707
TI  - Case history number 93: congenital lobar emphysema.

PMID- 1033709
TI  - Decreased arterial oxygenation during sodium nitoprusside administration for
      intraoperative hypertension.

PMID- 1033710
TI  - A method for inserting the Carden tube.

PMID- 1033711
TI  - Comparison of Dot test and digit-symbol test for street fitness of outpatients.

PMID- 1033712
TI  - Acute maxillary sinusitis complicating nasotracheal intubation: a case report.

PMID- 1033713
TI  - Supine hypotensive syndrome caused by intra-abdominal mass: a case report.
AB  - An obese woman who presented with 3 separate intra-abdominal masses developed a
      supine hypotensive syndrome following induction of general anesthesia. The
      hypotension was corrected by positioning the patient in a left lateral tilt and
      by releasing intra-abdominal pressure. Following decompression of the vena cava,
      arterial and central venous pressure rose and remained at a high level. Urine
      output was poor until IV furosemide was administered.

PMID- 1033714
TI  - Accuracy, brevity, clarity: three principles of good medical writing.

PMID- 1033715
TI  - Use of monitor for ketamine in radiotherapy.

PMID- 1033716
TI  - Write to inform, not to impress.

PMID- 1033717
TI  - What route of administration for K+ solutions.

PMID- 1033718
TI  - How do benefits of hemodilution balance O2 reduction.

PMID- 1033719
TI  - Effect of PaCO2 on O2 consumption during cardiopulmonary bypass.

PMID- 1033720
TI  - Informed consent suit against anesthesiologist.

PMID- 1033721
TI  - Uredofos: anthelmintic activity against nematodes and cestodes in dogs with
      naturally occurring infections.
AB  - A new broad-spectrum anthelmintic, uredofos, was tested in 146 dogs by single and
      multiple oral dosing. Single doses of 100 and 50 (but not 25) mg/kg were totally
      effective in removing Dipylidium caninum and Taenia spp from 46 dogs with
      infections of tapeworms. Among groups of 15 to 20 dogs, the average percentage
      efficacies against Toxocara canis for single soese of 100, 50, and 25 mg/kg were
      98, 96, and 81%, respectively. The average percentage of efficacies against
      hookworm (Ancylostoma caninum) were greater than 96% in dogs treated with single
      doses of 100, 50, or 25 mg/kg and were 100% in the 35 dogs given 2 or 3
      treatments (24-hour intervals) at dose levels of either 25 or 50 mg/kg. The
      whipworm, Trichuris vulpis, was not efficaciously eliminated by single doses of
      25, 50, and 100 mg/kg (av percentage of efficacies of 30, 35, and 71%,
      respectively). Efficacy against T vulpis markedly improved when 2 doses were
      given at a 24-hour interval (av percentage of efficacies were 89% at dose level
      of 25 mg/kg and 99% at dose level of 50 mg/kg). At either dose (25 or 50 mg/kg),
      3 daily treatments were no more efficacious against whipworms than were 2 doses.
      There was no evidence of drug toxicosis in any dogs tested. It was concluded that
      uredofos is highly effective against canine tapeworms, ascarids, and hookworms
      when given as a single dose of 50 mg/kg and against whipworm when given at dose
      level of 50 mg/kg/day for 2 days.

PMID- 1033722
TI  - Comparative effects of uredofos, niclosamide, and bunamidine hydrochloride
      against tapeworm infections in dogs.
AB  - A single dose of a new broad-spectrum anthelmintic, uredofos, was more effective
      than single doses of either bunamidine hydrochloride (HCI) or niclosamide in
      removing natural infections of Dipylidium coninum from pound dogs, as determined
      by necropsy examination for scolices. The efficacy of uredofos was equal to that
      of bunamidine HCI and exceeded that of niclosamide in removing Taenia spp from
      his host. All of 12 dogs harboring D caninum and all of 5 dogs harboring Taenia
      spp were completely cleared of tapeworm infection following treatment with
      uredofos at 50 mg/kg of body weight. Bunamidine HCl cleared 9 of 11 dogs (82%) of
      D caninum and 5 of 5 dogs of Taenia spp. Niclosamide had the least anticestodal
      activity of the 3 drugs; 2 or more scolices of D caninum were found at necropsy
      in each of 12 dogs treated with this drug. Four of 5 dogs were cleared of Taenia
      spp following niclosamide therapy. Untreated control dogs did not shed tapeworms
      of either species during a 3-day period of posttreatment fecal collections, but
      did have tapeworms at the time of necropsy.

PMID- 1033723
TI  - Use of bovine arterial heterografts in lower extremity arterial reconstruction.

PMID- 1033724
TI  - [Infantile nephrosis. Microcystic renal disease (author's transl)].
AB  - Two siblings, male and female with nephrotic syndrome of neonatal onset are
      reported. Both parents were healthy as well as another 5 year-old brother. Both
      died under two months. Their clinical, biochemical and immunological data are
      described, and the more common causes of N.S. (i.e. syphilis, toxoplasmosis,
      tuberculosis) ruled out. Pathology was available only from one of the cases, and
      the lesions were comparable to those described by finnish authors as
      corresponding to "congenital" N.S. This report is an additional evidence of the
      presence of this entity out of Finland.

PMID- 1033725
TI  - Myocardial infarction in men in the third decade of life.

PMID- 1033726
TI  - [Microbial growth and fuel tanks hazards (author's transl)].
AB  - Fuel tanks are susceptible to contain a microflora consisting of bacteria and
      fungi which appear as sludge at the bottom of the tanks. This microflora is quite
      variable. Various strains of microorganisms were isolated, belonging to the
      following genera: Pseudomonas, Acinetobacter, Mycococcus, Penicillium,
      Aspergillus, Candida, Cladosporium. These strains are generally adapted to
      hydrocarbons though non adapted strains are also found, which develop with the
      help of metabolites excreted by the adapted strains or their lysates. The
      microorganisms use mostly the paraffinic fraction of the fuel. Some strains
      attack also aromatic hydrocarbons. Contaminated fuels were found to contain
      noticeable amounts of fatty acids. The study of the production of organic acids
      by strains isolated from fuel tanks shows that many strains are able to excrete
      organic acids. The nature of the fatty acids produced depends upon the strain: in
      some dases they correspond to the branched paraffins contained in the fuel. The
      comparison of microbial growth and organic acid production in mixed cultures with
      fuel with various quantities of fuel to water shows that the large amount of fuel
      compared to water in a fuel tank can be responsible for the importance of
      microbial growth and organic acids.

PMID- 1033727
TI  - Experimental cleavage of chorioretinal scars by traction and subretinal fluid.
AB  - The resistance to separation by localized traction and exudative retinal
      detachment of experimental chorioretinal scars produced with argon laser
      photocoagulation, cryothermy and diathermy was tested in rabbits. In vivo, the
      area of retinal separation over the scar was similar to that obtained by traction
      on normal retina. Moreover, the retinal cleavage occurred at the level of the
      scar regardless of the scar inducing modality, indicating that the scar is the
      weakest point in the retina-pigment epithelium joint. However, spaced and dense
      chorioretinal scars produced by argon laser photocoagulation, diathermy and
      cryothermy usually remained attached after experimental production of exudative
      retinal detachments with penicillin G intravitreal injections. This study
      indicates that the resistance to detachment of the normal retina by traction may
      be as strong as that of the scarred tissue and that the chorioretinal scars'
      effect is related to lesser fluid penetration into the treated area.

PMID- 1033728
TI  - Determination of bilirubin in amniotic fluid: a comparison of some current
      methods.
AB  - Three methods for the estimation of bilirubin in amniotic fluid are compared. The
      within-batch precision and recovery of bilirubin by each method has been studied,
      and the effects of the presence of haemoglobin, methaemoglobin, and
      methaemalbumin in varying concentrations have been investigated. Measurements on
      amniotic fluid from patients with rhesus isioimmunization have also been compared
      and regression equations calculated. The results of the three methods agree
      reasonably well so long as no haemoglobin degradation products are present. It is
      suggested that in the presence of these products a method involving organic
      solvent extraction of bilirubin gives the most accurate result.

PMID- 1033729
TI  - Timing of fertilization and sex ratio of offspring--a review.
AB  - Evidence is reviewed for the hypothesis that there is a causal connection between
      the time of fertilization within the menstrual cycle and the sex of the resulting
      zygote.

PMID- 1033730
TI  - [Lethal and mutagenic action of nitrosomethylbiuret on a culture of the
      mycophilic fungus, Didymocladium ternatum].
AB  - The effect of N-nitrozo-N-methylbiuret (NMB) on various features of Didymocladium
      ternatum, an organism producing termatin was studied. It was found that the
      lethal effect of NMB depended on the exposure time, prolongation of which
      resulted in increased numbers of the plus variants, morphological mutations and
      reverses into the populations. Variants possessing 8 times higher activity as
      compared to the initial culture were obtained as a result of selection of active
      variants.

PMID- 1033731
TI  - [Use of paper discs in determining the biological activity of mycoheptin by the
      agar diffusion method].
AB  - Diffusion of mycoheptin from the discs into agar was studied. A procedure
      providing practical use of the discs for quantitative estimation of mycoheptin
      activity was developed. A possibility of using the discs in the assay of
      solutions containing significant amounts of an organic solvent was shown.

PMID- 1033732
TI  - Active site studies of human thrombin and bovine trypsin: peptide substrates.

PMID- 1033733
TI  - Outcome of very severe birth asphyxia.
AB  - The aim of this study was to establish the outcome of very severe birth asphyxia
      in a group of babies intensively resuscitated at birth. 48 infants, born between
      1966 and 1971 inclusive, were selected; 15 were apparently stillborn and 33 had
      not established spontaneous respirations by 20 minutes after birth. One-half of
      them died, but 3 to 7 years later three-quarters of the survivors are apparently
      normal. Later handicap was associated with factors leading to prolonged partial
      intrapartum asphyxia, while acute periods of more complete asphyxia were not
      necessarily harmful.

PMID- 1033734
TI  - Factors regulating tapeworm populations: dispersion of eggs of Taenia hydatigena
      on pasture.
AB  - A dog with four patent Taenia hydatigena was placed at a fixed site on a pasture
      for 50 days. The spread of the eggs was determined by grazing lambs for 10 days
      on various plots, and counting the cysts present at autopsy. Some 'wild' eggs
      were detected on the pasture before the dog was introduced. Nevertheless, a
      marked divergence from randomness was detected in the cyst counts of lambs grazed
      within 80 metres of the kennel but not beyond from 10-20 and 40-50 days after the
      dog had been introduced. The main egg clusters remained within a radius of 25
      metres.

PMID- 1033735
TI  - Changes in diurnal temperature and feeding patterns of rats during repeated
      injections of heroin and withdrawal.
AB  - Rectral temperatures and feeding activity were measured in adult male rats every
      30 min for 4 hr, then every 4 hr following daily s.c. injections at 08:00 or
      20:00hr or saline or heroin. Initial heroin injections disrupted diurnal
      temperature and feeding rhythms: 5 mg/kg heroin HCl induced hyperthermia and
      abolished feeding for 2 hr; 20 mg/kg led to hypothermia, then hyperthermia and
      abolished feeding for 4 hr. By the 5th heroin day hyperthermia and increased
      feeding occurred in all groups with a shorter latency to onset. Total food intake
      was higher than on the 1st heroin day but the diurnal patterns remained
      disrupted. Changes in both diurnal rhythms again occurred on the 1st withdrawal
      day as hypothermia, sporadic feeding and hyper-irritability were observed. By the
      5th withdrawal day diurnal temperature and feeding rhythms resembled those of the
      control period. Monitoring diurnal temperature and feeding patterns of rats
      reveals characteristic dose-related disruptions after heroin which are modified
      by repeated doses as tolerance develops and which eventually disappear on
      withdrawal.

PMID- 1033736
TI  - Time-course of apomorphine in the brain of the immature rat after apomorphine
      injection.
AB  - The time-course of apomorphine in brain was studied in 7-day-old and young adult
      rats following i.p. injection of 10 mg/kg apomorphine. In the adult animals
      continuous stereotypes behaviour (SB) commenced within 1-2 min and was no longer
      present at 75 min. The peak concentration of apomorphine was present at 5 min and
      then declined exponentially (half-life = 10.5 min); only trace amounts (less than
      0.01 mug/g) were present at 90 min. In the immature rat apomorphine induced an
      initial phase of intermittent locomotion lasting about 10 min after which the
      rats appeared sedated; 60-80 min after injection intermittent SB emerged and
      terminated 150-180 min after the apomorphine injection. The peak brain
      concentration of apomorphine was present at 10 min and then declined
      exponentially (half-life = 28 min). Significant amounts of apomorphine were still
      present in brain at 150 min and trace amounts evident at 180 min. The reason for
      the delayed onset of SB in the immature rat is unclear. The longer half-life is
      presumably related to incomplete development of enzyme systems metabolizing
      apomorphine in the immature animal.

PMID- 1033737
TI  - Ultrastructural alterations of the nerve cell bodies in the dog superior cervical
      ganglion, following surgical destruction of the hypothalamus.

PMID- 1033738
TI  - Comparative study on vagotomy procedures in relation to biliary composition.

PMID- 1033739
TI  - Cancer immunotherapy with BCG for patients with stomach cancers.

PMID- 1033740
TI  - [Electron microscopic studies on endocrine cells and exocrine cells in gastric
      mucosa of rats. III. Effects of vagotomy on exocrine cells and endocrine cells
      (author's transl)].

PMID- 1033741
TI  - [Effect of glucagon administration on blood glucose level in totally
      depancreatized dogs (author's transl)].

PMID- 1033742
TI  - Treatment of shunt infection: conversion of external ventricular drainage to
      gastric shunt for persistent ventriculitis.

PMID- 1033743
TI  - Successful ligation of the patent ductus arteriosus in a 1,710-gram premature
      baby with RDS, and the review of the literature.

PMID- 1033744
TI  - [Ca and P metabolism in the skeletal system of the dairy cow as shown in
      histometric follow-up studies on the substantia spongiosa of the tuber coxae].
AB  - 1. Histometric follow-up checks of the Substantia spongiosa of Tuber coxae in
      dairy cows have shown the trabecular percentage of the skeleton to decline
      continuously from the onset of lactation and to reach its lowest point in the
      last third of the lactation period. This was followed by some rise up to the next
      lactation, but the original values were not restored. 2. The percentage of
      spongiosa trabeculae, consequently, drops along with growing age, and so does the
      absolute trabecular surface. 3. No unambiguous dependence of trabecular surface
      on milk yield was established. 4. The results obtained from the above checks are
      discussed with reference to the physiological dynamics of the bone system as a
      mobile store of minerals. Some of the aspects mentioned are of greater relevance
      to practice.

PMID- 1033745
TI  - [Alveolar hydatid disease of the liver. An experience based on 20 cases. I.
      Epidemiological, clinical, biological and radiological studies (author's
      transl)].

PMID- 1033746
TI  - [Study of scalp hair patterns in the newborn infant].
AB  - A study of scalp hair patterns in 503 healthy patterns in 503 healthy neonates
      (260 boys and 243 girls) of more than 36 weeks gestation produced the following
      observations: 1.--A single whorl situated to the right of the midline in a
      clockwise rotation is the most frequent pattern. 2.--In 5.96% of cases there is a
      pattern not previously identified which we have called triradius and which is
      characterised by the arrangement of three locks of hair without a clear clockwise
      rotation. 3.--75.4% of the patterns, whatever their type, are located 2 to 4 cms
      from the posterior fontanelle. 4.--The percentage of whorls, double whorls,
      triradii and their position (right, left of midline) are significantly different
      according to sex. 5.--By contrast there is no significant racial difference in
      these parameters.

PMID- 1033747
TI  - Sensitization to milk and soy proteins.

PMID- 1033748
TI  - Twin studies of affective illness.
AB  - In a summary of the major twin studies of affective illness, there are
      significant differences between monozygotic (MZ) and dizygotic (DZ) concordance
      rates for both unipolar and bipolar illness, indicating the importance of genetic
      factors in the etiology of affective illness. However, since 28% of MZ twins are
      discordant for bipolar illness and 60% of MZ twins are discordant for unipolar
      illness, environmental factors are important as well. In addition, there is a
      significant difference between unipolar and bipolar concordance for MZ twins
      (although not for DZ twins). This supports other evidence that unipolar and
      bipolar illness are separate entities, and it suggests the possibility that
      genetic factors are more important in the occurrence of bipolar illness than in
      unipolar illness.

PMID- 1033749
TI  - Chronic alcoholism and the pancreas.
AB  - In rats given 15% solution of ethyl alcohol (v/v) instead of drinking water
      adlibitum for eight months, histochemical analysis showed a dictinct fall in
      activities of the oxidative enzymes (succinate and lactate dehydrogenases, DPNH
      diaphorase) in the centro-acinar cells of the pancreas and in the islets of
      Langerhans.

PMID- 1033750
TI  - The influence of cystamine on pharmacokinetics and pharmacodynamics of
      thioridazine.
AB  - A study on the influence of cystamine on the kinetics and dynamics of the action
      of thioridazine has been carried out. Higher levels of this drug in the blood and
      lower levels in the brain tissue than those in unpremedicated rats were
      determined. Half-life of thioridazine underwent shortening from 2-55 hr to 1-05
      hr. Excretion of thioridazine with bile was not significantly affected by
      premedication with cystamine. beta-Glucuronidase activity, after an initial drop
      on the first day following premedication, increased to levels higher than the
      control values. The dynamics of the action of the thioridazine were little
      affected. The cataleptic action of thioridazine was enhanced on the first day
      after premedication with cystamine. Thioridazine depressed exploratory activity
      in rats more significantly only during the first three days after cystamine
      premedication.

PMID- 1033751
TI  - Varicose veins: facts and fantasy.
AB  - The high prevalence of varicose veins in Western countries contrasts with their
      relative rarity in traditionally living communities in the Third World. Evidence
      is presented in support of the hypothesis that a major causative factor is the
      transmission of raised intra-abdominal pressures to the veins of the legs. One
      important cause of these pressures is the abdominal straining necessitated to
      evacuate small firm stools, which in turn are the result of fiber-depleted diets.

PMID- 1033752
TI  - Postoperative acalculous cholecystitis due to Torulopsis glabrata.
AB  - Acute acalculous cholecystitis due to Torulopis glabrata, an opportunistic yeast,
      developed postoperatively in a 70-year-old man who had an extremely complicated
      course after resection of an abdominal aortic aneurysm. The infection first
      appeared as an acute surgical abdomen, three days after resumption of solid food
      intake subsequent to a prolonged ileus and after 31 days of parenteral
      hyperalimentation. The condition was successfully treated by cholecystostomy; at
      the time of writing, six months after cholecystostomy, there are no
      gastrointestinal symptoms.

PMID- 1033753
TI  - [The replacement of skim milk in the diet of young pigs with an extremely short
      suckling period. 1. Report. A comparison of skim milk, fish meal and extracted
      soy beans as a protein source in conjunction with whole wheat meal in a liquid
      feed].
AB  - 40 piglets were reared in separate cages from the 13th to the 28th day of age and
      received a liquid milk diet (controls) or a substituted liquid diet. Half of the
      protein requirements of the young pigs were covered from skim milk, the other
      half was supplied through fish meal, extracted soya bean meal or a combination of
      both meals. Whole wheat meal was used as source of substitution energy. The
      ration containing extracted soya bean meal reduced all the digestibility
      coefficients with the exception of NFE. As a result, the levels of energy and
      nutrient intake and the rates of weight increase were lower in the experimental
      groups receiving the soya bean meal diet than in the control group. The same
      performance level as with the control diet was achieved when 50% of the skim milk
      in the experimental diet were replaced by wheat and fish meal.

PMID- 1033754
TI  - Haemagglutination of trypsin modified human erythrocytes by chagres virus.

PMID- 1033755
TI  - Plaque formation by African swine fever virus in chick embryo fibroblasts in the
      absence of CO2 atmosphere.
AB  - A plaque assay method using ASFV previously adapted to growth in chick embryo
      fibroblasts is described. Chick embryo fibroblast monolayers under bactoagar or
      methylcellulose have been employed using cysteine, arginine, DEAE-Dextran and
      HEPES as additives. Plaque production was optimal under methylcellulose. HEPES
      rendered the plaques more clear when used with the overlay. Arginine enhances
      plaque formation with bactoagar, and DEAE-Dextran doubles the plaque size. The
      growth curve of ASFV in chick embryo monolayers has been studied.

PMID- 1033756
TI  - [Development of the brain stem reticular formation during ontogenesis of lower
      simians as compared with man].
AB  - The work has shown a number of common features in the structural organization of
      the brain stem reticular formation in the adult rhesus monkey and man. According
      to the peculiar features and developmental features the reticular nuclei may be
      divided into 3 sections (median, medial and lateral) having different genesis. In
      ontogenesis all the nuclei of the reticular formation undergo differentiation and
      specialization due to the complication of the brain as a whole. This process,
      however, goes differently in ontogenesis of the macaque and man which can be seen
      in the heterochronous rate of their development, namely, in the macaque the terms
      of maturation of the reticular nuclei are somewhat more accelerated. The work
      shows changes in the density of cells, the volume of neurones and all the
      reticular formation in relation to the volume of the brain stem as a whole.
      However, the differences found in ontogenesis of the macaque and man are mainly
      of quantitative and idioadaptive character.

PMID- 1033757
TI  - Hyperreactivity and aggressiveness following infusion of local anesthetic into
      the lateral septum or surrounding structures.

PMID- 1033758
TI  - Agonistic behavior in wild and inbred Mus musculus.

PMID- 1033759
TI  - A theory of behavioral generality and specificity during mild stress.
AB  - A definitional system is given for the concepts of generality and specificity for
      behavioral variables, relating to signs and sizes of their intercorrelations. In
      particular, a mapping sentence is provided for defining the universe of
      observations for emotional behavior of mice under mild stress. Its three content
      facets are: (a) the temporal features of frequency, latency, and duration, (b)
      type of control, autonomic or voluntary, and (c) the experimental situation, the
      apparatus. Data from three studies published previously by other authors are
      analyzed by Smallest Space Analysis (SSA-I). In each case, the smallest space is
      found to be partitioned into contiguous regions corresponding to the elements of
      the three facets.

PMID- 1033760
TI  - [Norepinephrine levels and morphologic alterations of myocardium in chronic
      alcoholic rats].
AB  - Experimental alcoholism was produced in rats by giving them 32% alcohol as the
      only source of liquid for 4, 12, and 24 weeks. Control rats were given no
      alcohol. After 12 and 24 weeks on test the alcohol-fed animals developed
      pathologic changes and tissue catecholamine alterations of the myocardium.
      However after 4 weeks there were no differences in myocardial structure and
      norepinephrine levels between alcohol-fed and control rats. The present
      experiments indicate that marked increase in norepheinephrine concentration
      accompanies morphologic evidence of myocardial degeneration and may play a role
      in the development of the alcoholic cardiomyopathy.

PMID- 1033761
TI  - Extraretinal influences on the EOG potential.

PMID- 1033762
TI  - Characteristics of deoxythmidine transport and deoxythymidine kinase in 3T3
      cells.

PMID- 1033763
TI  - Identification of a cysteine residue of glutamate dehydrogenase that binds p
      chloromercuribenzoic acid.

PMID- 1033764
TI  - Variation of superoxide dismutases during the development of the fruit fly
      Ceratitis capitata L.

PMID- 1033765
TI  - Binding of antibodies to nitroxide spin labels and to the corresponding
      hydroxylamines.

PMID- 1033766
TI  - Inhibition of purine nucleotide biosynthesis by 3-deazaguanine, its nucleoside
      and 5'-nucleotide.

PMID- 1033767
TI  - Comparative study of mitochondrial and cytosol protein kinase activities.
AB  - Both cytosol and mitochondria of rat liver display protein kinase activity,
      cyclic AMP-independent, which is resolved by Sepharose 6B filtration and P
      cellulose chromatography into multiple forms phosphorylating, besides endogenous
      mitochondrial membrane-bound proteins, also exogenous phosphoproteins such as
      casein and phosvitin. However, the forms by far predominant in the cytosol
      phosphorylate both phosphorylserine and phosphorylthreonine residues of casein,
      while most of the activity associated to mitochondrial structures is due to the
      forms phosphorylating only phosphorylserine residues.

PMID- 1033768
TI  - Puromycin inhibition of eucaryotic ribosomes. Differences in sensitivity between
      polypeptide synthesis directed by endogenous mRNA and synthetic templates
      including poly(U).
AB  - In a protein synthesis sytem derived from porcine uteri we have made the
      following observations: 1. Synthesis directed by the endogenous mRNA of the
      system is more sensitive to inhibition by puromycin than poly(U) directed
      synthesis. 2. Synthesis directed by the synthetic templates poly(G,U) and
      poly(C,U) is more sensitive to inhibition by puromycin than poly(U) directed
      synthesis and frequently shows a sensitivity to puromycin similar to that
      directed by endogenous mRNA. 3. Protein synthesis was inhibited by three
      aminoacyloligonucleotides (C-A-Phe, C-A-Asp, and C-A-Pro) which are analogs of
      the 3' terminus of aminoacyl tRNAs. Of the three, C-A-Phe was the most active and
      C-A-Asp the least active but, unlike puromycin, inhibition by these compounds was
      the same for endogenous and poly(U) directed synthesis. These results are
      interpreted as supporting the proposal that the acceptor site of ribosomes
      contains an hydrophobic binding region which interacts with the side chain of
      aliphatic amino acids, and particularly with the aromatic side chain of
      phenylalanine.

PMID- 1033769
TI  - Single bilayer vesicles prepared without sonication. Physico-chemical properties.
AB  - Single shelled lecithin vesicles of uniform size (diameter = 300 A) are prepared
      without sonication by solubilizing unsonicated lecithin dispersions with sodium
      cholate and removing the detergent from the mixed lecithin - cholate micelles by
      gel filtration on Sephadex G-50. A homogeneous population of pure lecithin single
      bilayer vesicles free of multilamellar structures is obtained. The vesicle
      diameter is somewhat larger than the average diameter of sonicated vesicles. The
      curvature of the bilayer seems to be sufficiently large to allow for similar
      packing densities (areas/molecule) on the outer and inner layer of the bilayer.
      The morphology and some physico-chemical properties of these vesicles are
      described and compared with those of sonicated vesicles.

PMID- 1033770
TI  - [Morphometric study of alcoholic steatosis in rats].

PMID- 1033771
TI  - Dose-response effects of beta-phenylethylamine on stereotyped behavior in
      pargyline-pretreated rats.
AB  - We studied the dose-response and the time-course effect of beta-phenylethylamine
      (4.0-64.0 mg/kg, ip) on stereotyped behavior and motor activity in male Sprague
      Dawley rats pretreated 2 hr eariler with pargyline (0.25-8.0 mg/kg, iv).
      Stereotyped behavior, defined as repetitive, nongoal-directed head movements and
      sniffing, and changes in motor activity were observed immediately after injection
      of beta-phenylethylamine for a 1 hr period. With increasing doses of pargyline
      pretreatment, beta-phenylethylamine produced, in a dose-response relationship,
      progressively more stereotyped behavior accompanied by increased motor activity.
      Without pargyline pretreatment, only 64.0 mg/kg beta-phenylethylamine induced
      behavioral changes. Stereotyped behavior and increased motor activity had an
      onset at 4-6 min after the injection of beta-phenylethylamine, peak at 10-30 min,
      and gradual decline in the next 10-20 min. These results are discussed in terms
      of a possible relationship with the degree of inhibition of Type a and Type B
      monoamine oxidase acused by the different doses of pargyline.

PMID- 1033772
TI  - Influence of pyrazole on hepatic [1-14C] palmitate oxidation during acute ethanol
      intoxication.
AB  - When studied at different times following ethanol intubation, the effects of
      pyrazole, administered to rats prior to ethanol, affects differently the alcohol
      induced disturbances in hepatic [1-14C] palmitate oxidation. This peculiar time
      course of the pyrazole induced effects supports the relationship between active
      ethanol oxidation and inhibition of hepatic fatty acid oxidation, but also
      emphasizes the caution which must be taken when using pyrazole to study "in vivo"
      the mechanisms involved in the alcohol induced fatty liver.

PMID- 1033773
TI  - Screening for HBsag by hepanosticon in microplates.

PMID- 1033774
TI  - Feasibility of sugar production from agricultural and urban cellulosic wastes
      with Trichoderma viride cellulase.

PMID- 1033775
TI  - Cellulase production.

PMID- 1033776
TI  - [Clinical and epidemiological information about an outbreak of trichinosis in the
      population of the Kosice District in 1971].

PMID- 1033777
TI  - Purification of an exo-1,3-beta-glucanase from Candida utilis.
AB  - An exo-1,3-beta-glucanase (EC 3.2.1.-) has been purified from the culture fluid
      of the yeast Candida utilis, and its biochemical properties have been studied.
      The amino acid analysis revealed a high content of acidic amino acids. The
      purified enzyme had 20% carbohydrate and a net negative charge showing higher
      affinity for laminarin than for p-nitrophenyl-beta-D-glucopyranoside and yeast
      cell-wall 1,3-beta-glucans. In addition, the enzyme hydrolyzed the substrates
      starting from the nonreducing ends, releasing glucose as the exclusive hydrolysis
      product. The enzyme activity was strongly inhibited by lactones and also by some
      heavy-metal ions.

PMID- 1033778
TI  - Preliminary studies of pharmacological antigonism of anaphylaxis in the horse.
AB  - Systemic anaphylaxis was induced in seven groups of ponies. Systemic hypotension,
      pulmonary hypotension, and apnea were observed in the control group. Suppression
      of anaphylaxis was achieved most efficiently with sodium meclofenamate followed
      by acetylsalicylic acid and diethylcarboamazine. Tripelennamine and methysergide
      reduced anaphylaxis minimally and burimamide not at all. The findings suggest
      that histamine and serotonin are of relatively low significance in equine
      anaphylaxis whereas kinins, prostaglandins and slow reacting substance may be
      more important.

PMID- 1033779
TI  - [Enzymatic profile of uterine secretions of cows during estraus cycle].
AB  - The uterine secretions of 20 bovine females have been studied and the activity of
      the following five enzymes has been evaluated: aldolase, glucose-t
      phosphodeshydrogenase (G-6-PDH), sorbitol deshydrogenase, glutamic pyruvic
      transminase. Significant cyclic variations have been observed for aldolase and G
      6-PDH, aldolase activity being maximum during the estrogenic phase of the cycle
      whereas G-6-PDH activity has been more important during the progesteronic phase.
      These results indicate a significant uterine metabolic activity during the
      different phases of the reproduction processes.

PMID- 1033780
TI  - Concentration of manganese in the tissues of cycling and anestrous ewes.
AB  - A wide range of variation in concentration of manganese was found in the blood of
      51 cycling ewes although no significant differences were evident (P less than
      0.05) between days 4, 11 and 15 (day 0 = day of estrus) of the estrous cycle. In
      addition, no differences (P less than 0.05) were found in the manganese
      concentrations of various soft tissues of 15 ewes, killed on day 4 (five
      animals), day 11 (five animals) or during anestrus (five animals). The highest
      concentration of manganese was present in the liver, pancreas and kidney cortex,
      tissues which are rich in mitochondria. Among the tissues of the reproductive
      tract, the corpus luteum showed the highest manganese concentration and the level
      increased significantly (P less than 0.01) between days 4 and 11 suggesting that
      this trace element may be closely related to the metabolic and possible
      functional characteristics of this endocrine gland. Uterine horn and caruncles
      contained greater manganese concentrations than other components of the
      reproductive tract. The significance of these findings in relation to the effect
      of manganese intake on ewe fertility remains to be assessed.

PMID- 1033781
TI  - Effect of locoweed (Astragalus ientiginosus) feeding of fetal lamb development.
AB  - Locoweed, Astragalus lentiginosus, was fed to pregnant ewes for various periods
      during gestation. The principal gross effects on the developing fetuses were
      observed to be delayed placentation, decreased vascularization, fetal edema and
      hemorrhage, and alteration of cotyledon development. Deformed lambs and
      undersized lambs also occurred. Data from sheep fed locoweed during various
      periods of the entire gestation period are summarized and indicate that locoweed
      poisoning in the fetus as with the adult is a chronic type of intoxication. Also,
      poisoning of the fetus parallels poisoning in the dam.

PMID- 1033782
TI  - Cardiological signs and symptoms in Friedreich's ataxia.
AB  - The cardiovascular signs and symptoms were recorded in 36 patients with typical
      Friedreich's Ataxia (Group Ia, Ib). Seventeen patients were asymptomatic and this
      did not correlate with the severity of the disease. No pathognomonic clinical
      constellation was found to reveal the underlying cardiomyopathy.

PMID- 1033783
TI  - Implications of participant observation in medical studies.

PMID- 1033784
TI  - Thrombotic thrombocytopenic purpura.

PMID- 1033785
TI  - Immunochemical studies on the specificity of the peanut (Arachis hypogaea)
      agglutinin.
AB  - The specificity of purified, peanut agglutinin has been studied immunochemically
      by quantitative precipitin and inhibition assays. The lectin showed substantial
      differences in precipitating with blood-group substances of the same specificity.
      Of the B substances tested, horse 4 25% completely precipitated the lectin, Beach
      phenol insoluble failed to interact, and PM phenol insoluble gave an intermediate
      reaction. The lectin did not precipitate with A1 substances, with hog gastric
      mucin A + H substance, or with A2 substance WG phenol insoluble. Another A2
      substance, cyst 14 phenol insoluble, precipitated approximately 2/3 of the
      lectin. Of the H substances, Tighe phenol insoluble was inactive, JS phenol
      insoluble precipitated poorly, and morgan standard H precipitated about 80% of
      the lectin. However, first stage of Smith degradation, as well as Pl fractions
      obtained by mild acid hydrolysis of blood-group substances, gave products which
      precipitated strongly. The lectin was also completely precipitated by all
      precursor blood-group substances, as well as by cows 21 and 26, all having strong
      I-Ma, I-Ort, I-Step, and I-Da activities. Cow 18, which does not possess
      significant blood-group I activity, precipitated very slightly. Fractions of
      blood-group substances N-1 (Lea) and Tij (B) obtained by precipitation from 90
      percent phenol at higher concentrations of ethanol interacted better with peanut
      agglutinin. These differences in activity are ascribable to a heterogeneity
      resulting from incomplete biosynthesis of carbohydrate side-chains of blood-group
      substances, particularly resulting in variations in the numbers of DGalbeta1
      leads to 3DGalNAc or DGalbeta1 leads to 4DGlcNAc determinants. The agglutinin
      reacted with the hydatid cyst P1 glycoprotein, as well as with the previously
      studied antifreeze and sialic acid-free alpha1 acid glycoproteins, but not with
      pneumococcus type XIV polysaccharide. Inhibition of precipitation showed the
      lectin to be most specific for the disaccharide DGalbeta1 leads to 3DGalNAc,
      which is 14, 55, and 90 times as active as DGalbeta1 leads to 4DGlcNAc, DGal, and
      DGalbeta1 leads to 3DGlcNAc, respectively. DGalbeta1 leads to 3N-acetyl-D
      galactosaminitol has approximately 1/25th the activity of DGalbeta1 leads to
      3DGalNAc. Substitutions of DGlcNAc or LFuc on the DGal of active inhibitors
      completely blocked the activity, in line with the assumption that the combining
      site of the peanut lectin is a partial cavity. The oligosaccharides DGalbeta1
      leads to 4DGlcNAcbeta1 leads to 6-hexane-1,2,4,5,6-pentol(s) and DGalbeta1 leads
      to 3[DGalbeta1 leads to 4DGlcNAcbeta1 leads to 6]N-acetyl-D-galactosaminitol
      showed the same inhibitory activity as DGalbeta1 leads to 4DGlcNAc, suggesting
      that the combining site of the peanut agglutinin may not be complementary to more
      than a disaccharide...

PMID- 1033786
TI  - Autonomic innervation and plasma estradiol-17beta and progesterone levels in rats
      with subcutaneous ovarian autografts.
AB  - Ovaries were removed from female rats and immediately autografted into a
      subcutaneous pouch in the flank in order to quantitate the relationship of graft
      re-innervation, steroid secretion and vaginal smear pattern. Animals were killed
      at thre time periods: three days after grafting, on the first day a cornified
      vaginal smear appeared and at the first metestrus. In addition, control animals
      were killed at metestrus. Plasma samples were obtained from all rats and analyzed
      for estradiol-17beta and progesterone concentration by radioimmunoassay. At the
      first day of vaginal cornification after grafting, plasma estradiol-17beta
      (45.8+/-4.0 pg/ml) was elevated in comparison to controls at metestrus (24.0+/
      2.6 pg/ml), but plasma progesterone (21.5+/-4.0 ng/ml) was not different (30.6+/
      1.7 ng/ml). Subsequently, at the first metestrus following grafting, plasma
      estradiol-17beta (23.0+/-3.5 pg/ml) was comparable to control values. In
      contrast, progesterone was decreased (17.5+/-1.9 ng/ml). A definite correlation
      was detected between the vaginal smear and plasma levels of steroid hormones in
      the castrated female rat with subcutaneous ovarian autographs Histochemical
      techniques were used to study the adrenergic and cholinergic innervations of
      grafts three days after grafting, at the first day of vaginal cornification, and
      at the first metestrus. No correlation was shown between density of adrenergic or
      cholinergic innervation and plasma levels of estradiol-17beta and progesterone or
      onset of a cycling vaginal smear.

PMID- 1033787
TI  - [Physiology and physiopathology of muscle receptors].

PMID- 1033788
TI  - [Perinatal infection risk in a tropical hospital].

PMID- 1033789
TI  - An assay for sex hormone binding globulin based on affinity chromatography.

PMID- 1033790
TI  - Phosphate compounds in the erythrocytes of newborns with ABO systems haemolytic
      disease.
AB  - The following phosphate compounds of the erythrocyte acid-soluble fraction were
      subjected to chromatographic separation: ADP, ATP, adenylo-diphosphoglycerate,
      2,3-diphosphoglycerate, hexose monophosphate, hexose diphosphate. In each of the
      fractions total phosphorus, and in fraction II inorganic phosphorus, were
      estimated. The material was derived from ten newborns with haemolytic disease as
      a result of ABO incompatability and from ten full-term healthy newborns, just
      after birth. The concentration of the compounds assayed, except for 2,3-DPG (the
      values in both groups were similar) was higher in the erythrocytes from affected
      newborns, but lower than that found in the material derived from the newborns
      with Rh incompatibility. It is suggested that the metabolism of erythrocytes of
      the newborns with haemolytic ABO disease may be somewhat different from that in
      Rh incompatibility cases because in the former the haemolysis is weaker, the
      anaemia is less pronounced and the tissue hypoxia is of a smaller degree.

PMID- 1033791
TI  - [Clinical studies on the etiology of idiopathic pituitary dwarfism].

PMID- 1033792
TI  - [Effects of coenzyme Qlo or plasma aldosterone, deoxycorticosterone and
      corticosterone levels].

PMID- 1033793
TI  - [Plasma aldosterone and renin activities in various types of hypertension].

PMID- 1033794
TI  - [Measurement of blood digoxin concentration by radioimmunoassay].

PMID- 1033795
TI  - [Experimental studies and normal value of plasma CEA measurement by Z-gel
      methods].

PMID- 1033796
TI  - [Experimental studies of blood estradiol measurement by estradiol
      radioimmunoassay-kit].

PMID- 1033797
TI  - Acquisition of human blood group antigens by Schistosoma mansoni.
AB  - Juvenile forms of Schistosoma mansoni (schistosomula) have been cultured in human
      blood of various specificities and tested for the presence of blood group
      substances on their surfaces. The tests employed were survival following transfer
      into rhesus monkeys immunized against human blood substances, mixed agglutination
      reactions, and immunofluorescence. A, B, H AND Lewisb+ antigens were expressed at
      the surface when the parasites were cultured in blood of appropriate
      specificities. Rhesus, M N S, AND Duffy antigens could not be detected on the
      parasite surface following culture. The evidence suggests that the expressed
      blood group antigens are of host origin and are acquired by the parasite during
      culture, probably in the form of glycolipids or megaloglycolipids. It is likely
      that these substances are also acquired by parasites in the bloodstream of man.
      They may serve to mask surface parasite antigens, and so enable schistosomes to
      evade parasite-specific humoral or cellular immune responses.

PMID- 1033798
TI  - [Myotonic dystrophy with sensory disturbance - evaluation of the peripheral nerve
      involvement].

PMID- 1033799
TI  - [2 cases of myasthenia gravis associated with rheumatoid arthritis - a study of
      autoimmune diseases].

PMID- 1033800
TI  - [Autopsy report of demyelinating myelitis with painful tonic seizures].

PMID- 1033801
TI  - [Intermittent claudication due to the compression of the cauda equina- 3 cases
      diagnosed by the lumbar epidural venography].

PMID- 1033802
TI  - [EEG abnormality and clinical features of multiple sclerosis - analyse of 50
      cases].

PMID- 1033803
TI  - [Speech disorder with prominent dysprosody].

PMID- 1033804
TI  - [Long-term survival in cases of basilar artery occlusion].

PMID- 1033805
TI  - The EMI whole body scanner in the demonstration of lymph node enlargement.
AB  - Thirty-three cases with malignant disease due mainly to lymphoma and testicular
      tumours were evaluated by computerised tomography (CT) scanning on the EMI
      general purpose scanner. In many cases there were either more lymph nodes
      demonstrated than on lymphography or more disease shown in bone or the thorax
      than was suspected. CT scanning is particularly valuable in showing mesenteric,
      retrosternal, axillary and para-aortic lymph node enlargement. Bone, liver and
      pulmonary metastases were shown when not demonstrated by other methods as well as
      showing the extent of recurrence of malignant disease. In testicular tumours
      metastatic spread to paravertebral soft tissues behind the diaphragm was clearly
      demonstrated. This cannot be seen on lymphography. CT scanning appears to be the
      most accurate method to date of showing the extent of malignant disease,
      particularly in cases of lymphoma and testicular tumours.

PMID- 1033806
TI  - [Medical action and nursing action--their legal interpretations].

PMID- 1033807
TI  - [Nursing practiced in the world, overseas nursing observed by the editors of the
      Japanese Journal of Nursing Art. A discussion].

PMID- 1033808
TI  - [Nature of child-rearing--a study based on child development. 15].

PMID- 1033809
TI  - [Independence of individuals and mutual assistance].

PMID- 1033810
TI  - [Clinical nurse specialists in the United States--its significance in the future
      prospect of nursing in Japan].

PMID- 1033811
TI  - [Medical care as a support in restoration of one's health--the foundation of
      clinical medicine].

PMID- 1033812
TI  - The ideal form of assistance in clinical nursing--the foundation of medical
      assistance.

PMID- 1033813
TI  - [Theory of "assistance": its meaning and practice].

PMID- 1033815
TI  - [The world of psychiatric nursing--the function and character of psychiatric
      nursing].

PMID- 1033814
TI  - [Nursing action in the outpatient clinic and the problems posed to nurses].

PMID- 1033816
TI  - [Analysis of the practice of pediatric nursing--a question on the nature of
      "assistance" in pediatric nursing].

PMID- 1033818
TI  - [Nursing of dying patients--expectation of nursing].

PMID- 1033817
TI  - [Nursing of the aged: study on its basic problems and practice].

PMID- 1033819
TI  - [Life science and the meaning of "assistance"].

PMID- 1033820
TI  - Importance of behavioral assessment of the neonate.

PMID- 1033821
TI  - The P blood group system in pigeon breeders and pigeon breeder's disease.
AB  - A blood group P1-like antigen has been found in gram-negative bacilli isolated
      from pigeon droppings, in pigeon serum, and on pigeon red blood cells. As a
      probable resident of the environment of the pigeon loft, the antigen stimulated
      formation of anti-P1 antibody in eight of 11 pigeon breeders who belonged to the
      P2 blood group. Only one of 11 random hospitalized patients with the P2 blood
      phenotype had a detectable titer of anti-P1 antibody (P less than 0.01). The
      titer of anti-P1 antibody was not significantly different in symptomatic vs
      asymptomatic breeders. The presence or absence of anti-P1 antibody could not be
      correlated with any band of immunoprecipitates formed between pigeon breeder's
      serum and crude extract of pigeon droppings. The P antigen was identified in
      pigeon-dropping extracts of breeders with the P2 blood phenotype by inhibition of
      hemagglutination. We conclude that anti-P1 antibodies appear to be a component of
      the immunologic response to avian antigens of pigeon breeders but are probably
      unrelated to the pathogenesis of pigeon breeder's disease.

PMID- 1033822
TI  - The status of prevention in the education of child psychiatrists.
AB  - While the pioneers of modern child psychiatry focused much of their attention on
      prevention, the situation today is markedly different. A questionnaire survey of
      child psychiatric residency programs suggests that when attention is devoted to
      prevention in the education of child psychiatrists, it is often ambiguous,
      haphazard, and minimal. This impelled the authors to sample the current status of
      available knowledge about preventive child psychiatry with an assessment of the
      validity of the knowledge and its potential utility. These are followed by some
      suggestions for child psychiatric education.

PMID- 1033823
TI  - The effects of prenatal and perinatal complications on development at one year of
      age.
AB  - 35 variables descriptive of birth and obstetric complications, prematurity,
      maternal discomfort, and demographic status were studied for a sample of 322
      infants. Factor analyses of these variables resulted in 7 major factors that were
      used to predict developmental status at 1 year of age for 233 of the subjects.
      Factors identified as "prematurity," "delivery and related variables,"
      "ethnicity," and "complications" made significant independent contributions to
      Cattell DQ at 1 year. When Cattell DQs were corrected for the effects of
      gestational age, only delivery and related variables remained critical,
      confirming the importance of this factor for later development.

PMID- 1033824
TI  - [Congenital venous dysplasia of the right lower limb associated with Kasabach
      Merritt syndrome in a 14 year old child. Successive destruction of the knee and
      hip. Conservative treatment].

PMID- 1033825
TI  - Mushroom poisoning.

PMID- 1033826
TI  - [Acute intermitting porphyria].

PMID- 1033827
TI  - Effect of melatonin on the reproductive systems of male and female Syrian
      hamsters: a diurnal rhythm in sensitivity to melatonin.
AB  - Hamsters were maintained on a long photoperiod (14L:10D) and were injected once
      daily with melatonin (10-25 mug) or sesame oil. Males which received melatonin
      during the afternoon (e.g., 6.5-13.75 h after lights-on) showed regressed testes
      and decreased levels of serum LH and FSH after several weeks of treatment.
      Injections of the oil vehicle or injections of melatonin given in the morning (3
      h after lights-on) had no detectable effect on testicular size or on serum
      gonadotropins. Females which received melatonin during the afternoon became
      acyclic after several weeks of treatment and showed a diurnal pattern of LH
      secretion. The acyclic females required 4-6 weeks to resume estrous cyclicity
      following termination of the melatonin injections. The effects of melatonin on
      gonadal function and on serum gonadotropin concentrations in both sexes were
      similar to the previously observed effects of prolonged exposure to short
      photoperiods. These results indicate that chronic daily injections of melatonin
      can depress reproductive function in hamsters and that the effectiveness of the
      injections is dependent upon the time of day at which they are administered.

PMID- 1033828
TI  - Total and free testosterone and total and free 17 beta-oestradiol in normally
      menstruating women.
AB  - Estimations of plasma total and free testosterone (T) as well as of total and
      free 17beta-oestradiol (E2) have been performed in 6 normal women throughout the
      menstrual cycle. The plasma total T levels showed a small but significant
      cyclical variations, with significantly increased values around the midcycle (p
      less than 0.001). The pattern of free T during the cycle was similar to total T.
      Regarding total plasma E2, two typical peaks occurred, which were also observed
      in plasma free E2. Changes in testosterone-17beta-oestradiol binding globulin
      have not been detected throughout the menstrual cycle.

PMID- 1033829
TI  - Significantly decreased apparently free testosterone levels in plasma of male
      homosexuals.
AB  - Total and free plasma testosterone (T) were determined in male homosexuals. While
      total T showed no significant difference to a heterosexual control group,
      apparently free T in plasma was significantly lower (p less than 0.001) in 35
      male homosexuals (mean +/- SD = 10.7 +/- 3.3 ng/100 ml) than in 38 male
      heterosexuals of similar age (13.3 +/- 4.5 ng/100 ml).

PMID- 1033830
TI  - Mercury in Alaskan Eskimo mothers and infants.
AB  - The potential danger of natural mercury accumulation in the diet of the Eskimo is
      evaluated through mercury levels determined in cord blood, placenta, maternal
      blood, hair, and milk of 38 maternal-infant pairs from Anchorage and the Yukon
      Kuskokwim Delta. Although mercury levels are not discernably dangerous, trends to
      larger accumulations in maternal and fetal RBC and placental tissue with
      proximity to the sea and consumption of seals during pregnancy provide the basis
      for considering possible indicators of neonatal involvement. Mercury level in RBC
      from cord blood appeared as the best potential indicator of this involvement,
      although relationships with the mother's diet and level of mercury in the
      placenta also appear useful. In this area, average and maximal mercury levels in
      cord blood are 39 and 78 ng/ml, respectively, far below the acknowledged toxic
      level in infants of these mothers who eat seals or fish every day during their
      pregnancy.

PMID- 1033831
TI  - The role of biotransformation in chemical-induced liver injury.
AB  - The role of drug metabolism in chemical-induced liver injury is reviewed.
      Parameters for studying the formation of chemically reactive metabolites are
      discussed and the factors that alter the formation and covalent binding of
      reactive metabolites are selectively emphasized. Some of the experimental work
      that led to these concepts is discussed, especially the chemical toxicology of
      the hepatic injury produced by acetaminophen, bromobenzene, furosemide, isoniazid
      and iproniazid.

PMID- 1033832
TI  - Characterization and action of meiotic maturation inhibitors in starfish ovary.

PMID- 1033833
TI  - Differential effects of lectins mediating erythrocyte attachment and ingestion by
      macrophages.

PMID- 1033834
TI  - Nuclear proteins. III. The fibrillar nature of the nuclear matrix.

PMID- 1033835
TI  - The effect of inhibitors of microtubule and microfilament function on the
      cellular slime mould Dictyostelium discoideum.

PMID- 1033836
TI  - Is the movement of single cells within solid tissue masses induced by
      trypsinization?

PMID- 1033837
TI  - Serial lateral hypothalamic destruction: infancy and adulthood.

PMID- 1033838
TI  - Functional alterations of liver mitochondria in chronic experimental alcoholism.

PMID- 1033839
TI  - The specification of fertility planning status.
AB  - The principal obstacle to accurate measurement of fertility planning intentions
      in cross-sectional surveys is the disposition of the respondent to provide the
      interviewer with a reconstruction of the couple's history which departs more or
      less from what actually happened... Since married couples in America are now
      close to effective planning of fertility, the future of reproduction in the
      United States will depend much more than in the past on reproductive intentions.
      From this viewpoint, the uncertainty of reproductive intentions as shown here
      suggests extreme circumspection in using current reproductive orientations for
      future projections.

PMID- 1033840
TI  - Chemical modification of liver alcohol dehydrogenase with alpha-bromo-beta-(5
      imidazolyl) propionic acid.

PMID- 1033841
TI  - Polymerization of a major surface-associated glycoprotein, fibronectin, in
      cultured fibroblasts.

PMID- 1033842
TI  - The occurrence of a new type of proteochondroitin sulfate in the developing chick
      embryo.

PMID- 1033843
TI  - [Effect of mineral fertilizers on the content of glycosides in Convallaria
      majalis L].

PMID- 1033844
TI  - The effect of an extraluminal transducer on the reproductive capability of the
      rabbit.
AB  - An extraluminally attached microminiature force transducer, designed for
      reproductive tract contractility measurements, was investigated in terms of its
      effects on the physiology of the uterotubal junction in the rabbit. The presence
      or attachment process of the extraluminal force transducer (EFT) did not affect
      the rate of pregnancy or the number of embryonic implantation sites whether the
      attached device was silicone rubber or polyethylene-encased. The uterotubal
      junction was able to retain the blastocyst for the required time after mating,
      while an examination of postembryonic mortality revealed a rate of one resorption
      in some experimental groups. The gestation period was unaffected by the EFT,
      ranging from 30 to 40 days with a mode of 32, while histologic examinations
      revealed formation of a thin fibroblastic layer, some increased vascularity, and
      no abnormal leukocytic accumulation.

PMID- 1033845
TI  - [Binding mechanism in the copulation (author's transl)].

PMID- 1033846
TI  - [Electron microscopy studies on purpura pigmentosa progressiva].

PMID- 1033847
TI  - [Morphological contact reactions between dermal Langerhans cells and lymphocytes
      in purpura pigmentosa progressiva].

PMID- 1033848
TI  - Solubilization and peptide "mapping" of a large external glycoprotein fraction
      labelled by lactoperoxidase-catalysed iodination of cultured fibroblasts.

PMID- 1033849
TI  - Biosynthesis of phosphatidylcholine and phosphatidylethanolamine by germinating
      soya bean.

PMID- 1033850
TI  - Cholesterogenesis from tritiated water in rats: evidence against the existence of
      diurnal rhythms (1. Temporal effects).

PMID- 1033851
TI  - Cholesterogenesis from tritiated water in rats: evidence against the existence of
      diurnal rhythms (2. Effect of meal-feeding).

PMID- 1033852
TI  - Changes in lipogenesis during mammary-gland development.

PMID- 1033853
TI  - Glycolipid synthesis in hamster embryo cell cultures.

PMID- 1033854
TI  - Effect of histidinol on the initiation and elongation of protein synthesis in
      Krebs II ascites cells.

PMID- 1033855
TI  - Nitrogen metabolism in the photoresponsive phytopathogenic fungus Cercospora
      beticola.

PMID- 1033856
TI  - Carbon-utilization patterns in the photoresponsive fungus Cercospora beticola.

PMID- 1033857
TI  - Effect of polyinosinic acid-polycytidylic acid on establishment, and on
      spontaneous and chemical transformation of Balb/c mouse-embryo cells in culture.

PMID- 1033858
TI  - [The electrical conductivity in the vagina of ewes during the synchronization of
      oestrus (author's transl)].

PMID- 1033859
TI  - [Studies on plasma 5 alpha-dihydrotestosterone (author's transl)].

PMID- 1033860
TI  - [A new pregnancy diagnostic kit-Pregnosec (author's transl)].

PMID- 1033861
TI  - [Estrogen effect on the rabbit fimbrial RNA synthesis in vitro (author's
      transl)].

PMID- 1033862
TI  - [Experimental alloimmune ovulatory disorder in the rat. III Serological and
      immunohistochemical studies on ovary specific antigen and antibody (author's
      transl)].

PMID- 1033863
TI  - [Observations of the utero-tubal movement by 3-step method of
      hysterosalpingography (author's transl)].

PMID- 1033864
TI  - [Statistical analysis of infertile women in our clinic (author's transl)].

PMID- 1033865
TI  - [Sperm motility and kallikrein (author's transl)].

PMID- 1033866
TI  - [Sperm motile efficiency (author's transl)].

PMID- 1033867
TI  - The male climacteric.

PMID- 1033868
TI  - [Studies on Leydig cell function in patients with male infertility (author's
      transl)].

PMID- 1033869
TI  - [A clinical study on seminal vesiculogram in male infertility (author's transl)].

PMID- 1033870
TI  - [The effect of sequential pseudopregnancy-cyclofenil therapy on ovulatory sterile
      women (author's transl)].

PMID- 1033871
TI  - [The practical administration for sterility patients by psychophysiological
      therapy (author's transl)].

PMID- 1033872
TI  - [Statistical studies on the sterility in our clinic (author's transl)].

PMID- 1033873
TI  - Comparative studies on clinical, morphological and biochemical parameters in
      andrology.

PMID- 1033874
TI  - [Some experimental studies on the fertilized ova before implantation in the aged
      rats (author's transl)].

PMID- 1033875
TI  - [Studies on the blastocyst membrane of the rabbit (author's transl)].

PMID- 1033876
TI  - [Clinical studies on Cu-7: copper-IUD (author's transl)].

PMID- 1033877
TI  - [Clinico-pathological study on the aging phenomenon of the ovary (author's
      transl)].

PMID- 1033878
TI  - [Clinical and endocrinological studies in anovulatory women treated with
      Cyclofenil (author's transl)].

PMID- 1033879
TI  - The effect of endometrial cells on the growth and expansion of rabbit blastocyst
      in vitro.

PMID- 1033880
TI  - [Electron microscopic studies on the intramitochondrial dense deposits in the
      spermatozoa of a infertile man (author's transl)].

PMID- 1033881
TI  - [Histochemical localization of monoamine oxidase and monoamines in the
      reproductive tracts of male rats (author's transl)].

PMID- 1033882
TI  - [The effect of thawing temperature on acrosomal characteristics of bull
      spermatozoa (author's transl)].

PMID- 1033883
TI  - Synthesis of LDH-1 during mamalian oogenesis and early development.

PMID- 1033884
TI  - Enhancement of differentiation of lens and pigment cells by ascorbic acid in
      cultures of neural retinal cells of chick embryos.

PMID- 1033885
TI  - Cytogenetic analysis of oocytes and early preimplantation embryos from XO mice.

PMID- 1033886
TI  - The structural gene for alpha-mannosidase-1 in Dictyostellium discoideum.
AB  - We have isolated 4 independent mutations affecting alpha-mannosidase-1, a
      developmentally regulated activity in Dictyrostelium discoideum. Three of these
      result in a thermolabile alpha-mannosidase-1 activity. One mutation also affects
      the substrate affinity (Km) of the activity. In diploids these mutations show a
      gene dosage effect and are all alleles. The structural gene for alpha-mannosidase
      1, as defined by these mutations, defines a new linkage group, linkage group VI.
      alpha-mammosidase 1 is probably a homopolymer with subunits of 54,000 daltons. We
      have also mapped two temperature-sensitive-for-growth mutations onto two
      previously defined linkage groups.

PMID- 1033887
TI  - [Inheritance of human finger and palm dermatoglyphic characteristics].
AB  - The degree of genetic determination of 25 quantitative dermatoglyphic
      characteristics has been studied on family: twin material: 45 pairs of MZ and 75
      single-sex DZ twins; and 53 single-sex "parent-child" pairs. Approximating
      formulae were used to estimate main components of phenotypic variance due to
      additive interaction of genetic factors, to non-linear effects (intralocus
      dominance) and to the effect of total-familiar and random environmental factors.
      All the finger dermatoglyphic characteristics studied had a high degree of
      genetic determination (G greater than 0,80), and for most of them the
      contribution into the large variance of intralocus dominance effects was
      comparable with that of additive gene interaction, included in the determination
      of these characters. There are some palm dermatoglyphic characteristics ("ad"
      distance "cd" comb counting, "bad", "adt" and "cda" angles), which degree of
      genetic determination is low (G less than 0,35). At least ten quantitative finger
      and palm dermatogliphic characteristics with a high degree of genetic
      determination can be used for special studies in frames of multidimentional
      genetical analysis, including determination of twin zygosity type. Earlier
      described "indices" (using twin data) of relative role of genetic and environment
      factors in the determination of populational variability of quantitative
      characters are considered. None of them is shown to be a reliable estimate of the
      coefficient of genetic character determination. The use of these indices in
      practical studies can result in wrong conclusions on the degree and the character
      of genetic determination of quantitative characters.

PMID- 1033888
TI  - [Protective effect of caffeine on chromosomal structures of mammalian cells
      irradiated with UV-rays].
AB  - The effect of caffeine (2mM) on the frequency of structural mutations induced by
      UV light (lambda = 265 nm at an incident dose of 40 erg/mm2) in the primary
      culture of mouse embryonic fibroblasts is studied. A half-hour treatment with
      caffeine of cells at the time of the first mitosis metaphase decreased
      approximately by 2 times the frequency of chromosome aberrations induced by UV
      light at the S stage and observed at the metaphase of this or the next C-mitosis.
      The frequency of both breaks and exchanges decreased as the result of caffeine
      treatment. The persistence of the protective effect of caffeine at the time of
      the second C-mitosis suggests that the observed decrease of the aberration rate
      is accompanied by the true reparation of pre-mutational lesions in chromosomes;
      the nature of the reparative process and the time when it takes place is as yet
      not clear. Caffeine did not decrease the frequency of spontaneous structural
      mutations.

PMID- 1033889
TI  - Male meiotic behaviour and male and female litter size in mice with the T(2;8)26H
      and T(1;13)70H reciprocal translocations.

PMID- 1033890
TI  - An ultramicroscopic study on rigor mortis.
AB  - Gastrocnemius muscles taken from decapitated mice at various intervals after
      death and from mice killed by 2,4-dinitrophenol or mono-iodoacetic acid injection
      to induce rigor mortis soon after death, were observed by electron microscopy.
      The prominent appearance of many fine cross striations in the myofibrils
      (occurring about every 400 A) was considered to be characteristic of rigor
      mortis. These striations were caused by minute granules studded along the
      surfaces of both thick and thin filaments and appeared to be the bridges
      connecting the 2 kinds of filaments and accounted for the hardness and rigidity
      of the muscle.

PMID- 1033891
TI  - The use of sperm-specific lactate dehydrogenase isoenzyme for the identification
      of semen in dried stains.
AB  - The sperm-specific lactate dehydrogenase (LDH) isoenzyme (Blanco and Zinkham,
      1963; Goldberg, 1963) separated from other LDH isoenzymes of semen by
      polyacrylamide gel electrophoresis has been found to be suitable for specific
      differentiation of human semen from other human body fluids and semen of commonly
      encountered animals. Seminal isoenzymes were found to be stable even 4 weeks
      after storage in tropical conditions. The method gave substantially more positive
      results than microscopic identification of spermatozoa when applied to a large
      number of relatively old stains on actual crime articles. It is therefore
      valuable in a large number of cases involving normal males and also in
      interpreting results of immunological and enzymological individualisation of
      semen stains.

PMID- 1033892
TI  - [Neural mechanism of appetite].

PMID- 1033893
TI  - [Protective effects of general hypothermia on side effects of anticancer drugs in
      the "regional hyperthermic chemotherapy combined with temporary interruption of
      local blood-circulation" (author's transl)].

PMID- 1033894
TI  - [Studies on immunological responsiveness of cancer patients. I. Standardization
      of phytohemagglutinin-stimulated lymphocyte transformation].

PMID- 1033895
TI  - [Studies on immunological responsiveness of cancer patients. II.
      Phytohemagglutinin-stimulated lymphocyte transformation in patients with gastric
      or esophageal cancer].

PMID- 1033896
TI  - ["Coronary arteriographic findings in the patients of arteriosclerotic heart
      disease combined with cardiac arrhythmias or conduction defects" (author's
      transl)].
AB  - Correlation between cine-coronary arteriographic findings and various cardiac
      arrhythmias or conduction defects were studied in 40 patients with
      arteriosclerotic heart disease. These cases were divided into 3 groups according
      to the type of arrhythmias or conduction defects. The following conclusions were
      drawn. 1. In the group I of 25 patients whose arrhythmias were atrial origin,
      there were sinus bradycardia in 9, suins tachycardia in 5, atrial premature beats
      in 2 and atrial fibrillation in 9. Cine-angiographically, the degree of luminal
      stenosis of the main coronary arterial branches were mild to moderate in severity
      compared to that of the other two groups. However, it was remarkable that the
      sinus node artery was not visualized in 9 of 25 cases (36%). 2. The group II of 5
      patients who have shown premature ventricular contractions exhibited moderate to
      severe degree of stenosis of coronary artery trees, especially much more often in
      left anterior descending coronary arteries. 3. In the group III of 10 patients
      who had various type of intraventricular conduction defects, the degree of
      stenosis of the main coronary artery branches were usually severe and also, the
      number of the coronary artery involved in stenosis was increased. Interestingly,
      atrioventricular node arteries were not opacified in 5 of 10 cases. There were 2
      cases of complete A-V block where the atrioventricular node artery was not
      visualized at all both either from right or left coronary artery opacification.
      It seemed to be hard to draw a clear cut correlation between cine coronary
      angiographic pictures and a certain type of cardiac arrhythmias or conduction
      defects in such a small scale of study. However, cind coronary angiography may
      contribute to rule out local ischemia of the conduction tissue as a primary cause
      of the development of arrhythmias or conduction defects in patients with
      arterisclerotic heart disease.

PMID- 1033897
TI  - [Studies on the mechanism of lowering of the cholesterol level by ethyl-alpha-p
      chlorophenoxy-isobutyrate (clofibrate) (author's transl)].
AB  - Amimal experiments were conducted to elucidate the mechanism responsible for
      lowering the blood cholesterol level of mice by clofibrate (CPIB). 1. Cholesterol
      biosynthesis: (1) Cholesterol biosynthesis from acetate-1-14C or mevalonic acid-2
      14C in liver, blood, intestine and kidney was not changed when 0.3 X 10(-3) M
      CPIB was added to the liver homogenate, when mice were fed on a basal diet
      containing 0.1% CPIB for 10 days or fed on a basal diet containing 0.5% CPIB for
      18 days, and when fed on a diet containing both cholesterol and 0.5% CPIB for 10
      days. (2) However, the cholesterol biosynthesis in liver and blood of the mice
      fed on the basal diet containing 0.5% CPIB for 10 days was suppressed at the step
      of conversion of acetate to mevalonic acid. In addition, since the incorporation
      of acetate-1-14C into squalene and of mevalonic acid-2-14C into squalene and
      ianosterol was suppressed in the liver homogenate of the mice, the cholesterol
      biosynthesis was depressed at the step of conversion of mevalonic acid to
      squalene. Therefore, CPIB depressed the cholesterol biosynthesis at both steps
      before and after mevalonic acid. 2. The fecal excretion of the sterol-14C and
      bile acid-14C derived from injected cholesterol -14C: When mice injected with
      cholesterol-14C were kept on a basal diet or cholesterol-added diet containing
      0.1% CPIB, the excretion of sterol-14C and nonsaponifiable materials-14C in the
      feces was markedly increased in the case of basal diet as well as cholesterol
      added diet. However, the excretion of total bile acid-14C was not changed when
      mice were fed on the basal diet, but it was markedly increased when fed on the
      cholesterol-added diet. The specific radioactivity of sterol-14C in blood 30 days
      after injection was reduced in the basal diet or the cholesterol-added diet,
      while that in liver was not changed or increased. Total cholesterol level in
      blood 30 days after injection was not affected in mice fed on basal diet and was
      reduced in mice fed on the cholesterol-added diet. From the above facts, the
      lowering effective of CPIB on the blood cholesterol level appears to depend not
      on the alteration of the cholesterol biosynthesis but on the increase of
      excretion of sterol derived from the tissue cholesterol in the feces.

PMID- 1033898
TI  - [Effect of vitamin E on the alteration of the cholesterol metabolism with the
      aging of mice (author's transl)].
AB  - 1. Vitamin E (alpha-tochopherol acetate) 200 mg/kg was injected twelve times
      every five days into two groups of dd mice, one six months old and the other one
      month old. Thereafter the incorporation of acetate-1-14C or mevalonic acid-2-14C
      into sterols in the liver and kidney was examined. (1) In the liver, the
      incorporation of acetate-14C or mevalonic acid -14C into total lipid, total
      cholesterol, total fatty acid and proteins was lower in the old group than in the
      young group. When vitamin E was administered to the young group, hepatic
      cholesterol biosynthesis from the acetate-1-14C was reduced while total lipids,
      total fatty acid and proteins were not affected. Whereas when vitamin E was
      administered to the old group, the body weight increased, the hepatic cholesterol
      was reduced and the incorporation of acetate-1-14C into total lipids and proteins
      was increased while that into total cholesterol was reduced, and that into total
      fatty acid was not affected. The cholesterol biosynthesis was inhibited at the
      step of conversion of acetate to mevalonic acid in both young and old groups by
      the injection of vitamin E. (2) In the kidney the incorporation of acetate-1-14C
      into total lipid, total fatty acid and total cholesterol was more reduced in the
      old group of mice than in the young group. The administration of vitamin E to the
      young group of mice reduced the incorporation of acetate-1-14C into total lipid,
      total fatty acid and total cholesterol, while in the old group of mice
      administered with vitamin E the incorporation into total lipid and total
      cholesterol was not affected but that into total fatty acid was increased. The
      incorporation of mevalonic acid-2-14C into cholesterol was reduced in the young
      group of mice administered with vitamin E while the same was not affected in the
      old group. 2. When the old group of mice was fed with a diet containing vitamin E
      for two months, the excretion of bile acid-14C derived from injected cholesterol4
      14C or cholic acid-24-14C was increased and the disappearance of hepatic
      cholesterol-14C became more rapid. As a result, it may be said that aging brought
      about the reduction of the lipid biosynthesis in liver and kidney, which was
      recovered partially by the administration of vitamin E. With regard to the
      cholesterol metabolism, the aging increased total cholesterol level, which was
      adjusted by vitamin E. The effect of vitamin E appeared to depend upon the
      supression of cholesterol biosynthesis as well as the increase of cholesterol
      catabolism and the excretion of bile acid.

PMID- 1033899
TI  - [The tissue distribution and the effect of mercury on the hepatic cholesterol
      biosynthesis following the oral administration of methyl- and ethylmercurial
      compounds (author's transl)].
AB  - Hepatic cholesterol biosynthesis from acetate-1-14C, hepatic cholesterol level
      and accumulation of mercury into various tissues were examined following oral
      administration of methyl- or ethyl-mercury to mice (or rat) at next dosage
      levels, 80 ppm for 10-19 days, 50 ppm for 30 days and 100 ppm for 15 days. The
      results obtained were as follows. 1. Hepatic cholesterol biosynthesis was
      elevated at a dose of 80 ppm and decreased at a dose of 50 and 100 ppm. The
      change of hepatic cholesterol biosynthesis showed the negative correlation with
      that of cholesterol level. 2. In comparison between methyl-and ethylmercury, the
      latter accumulated more than the former in liver and spleen, while the former
      accumulated more than the latter in kidney, cerebum and skeletal muscle. The
      administration of ethylmercury caused more decrease of body weight, increase of
      hepatic cholesterol biosynthesis and hepatic cholesterol level than the
      administration of methylmercury.

PMID- 1033900
TI  - [A statistical study of autopsy cases in the department of legal medicine,
      Hokkaido University School of Medicine, during the last 10 years (author's
      transl)].
AB  - The mediocolegal autopsies performed in the Department of Legal Medicine,
      Hokkaido University School of Medicine, during the 10-year period, 1965-1974 were
      617 cases, 87 of them in newborns, 530 in infants and adults. Of cases autopsied
      as homicidal or suspicious deaths in infants and adults, 88.5% were recognized to
      be due to external causes, 9.1% to disease conditions and 2.5% undetermined. Of
      neonatal deaths, 10.3% were stillbirth, 78.2% live birth and 11.5% undetermined.
      Among the deaths due to external causes in infants and adults, 43.3% were
      homicidal, 7.2% suicidal, 32.6% accidental and 16.6% undetermined. Of external
      factors causing death, 42.9% were force, 36.8% asphyxiaton, 8.0% chemical
      substances and 8.0% heat. The causes of homicidal deaths inflicted with cutting
      or piercing instruments were circulatory disturbance, asphyxia and infection. In
      deaths inflicted with blunt instruments, they were mostly injuries of central
      nervous system and circulatory disturbance in the minority. All categories of
      causes of death were recognized in accidental deaths. All neonatal deaths were
      due to external causes. Their causes of death were mostly asphyxia and blunt
      force injuries of head.

PMID- 1033902
TI  - [Physicians and Senryu poetry].

PMID- 1033901
TI  - [Effects of alcohol on the liver].

PMID- 1033903
TI  - [Headache].

PMID- 1033904
TI  - Immunogenicity of "single component" port insulin.
AB  - Twelve diabetic subjects who were not previously treated with insulin were
      divided into two groups of six each. Group I was treated with single component
      pork insulin and Group II was treated with standard (USP) insulin for 5 to 10
      months. Three out of six in Group I, and five in Group II, developed circulating
      insulin antibodies. Daily insulin requirement in the two groups were almost the
      same. Insulin antibody titer did not fall in three insulin-treated diabetic
      subjects when single component pork insulin was substituted for USP beef-pork
      insulin. This study shows that the single component insulin is antigenic in human
      subjects.

PMID- 1033905
TI  - Endometrial blood flow in rats.
AB  - The endometrial blood flow was measured in rats by injections of 85Kr saline into
      aorta and measurements of the clearance of the radioactivity by a Geiger-Muller
      probe situated in the uterine lumen. Estrus and diestrus were determined by
      vaginal smears. The endometrial blood flow was found to be 0.88 +/- 0.08 (mean +/
      SEM) ml/g tissue/min in estus and 1.60 +/- 0.15 mg/g/min in diestrus. The
      experiment indicates that the endometrial blood flow and the total uterine blood
      flow change in opposite directions during the estrous cycle.

PMID- 1033906
TI  - Testosterone production by ovarian follicles of the domestic cat (Felis catus).
AB  - In order to determine whether the ovarian follicles of the domestic cat which
      normally ovulates following copulation, were similar to those of the rabbit
      steroidogenically, the following experiments were carried out. Follicles were
      dissected out of ovaries from nine estrous cats throughout the year and incubated
      in medium alone or with luteinizing hormone (LH) or human chorionic gonadotropin
      (HCG). Media were removed every 15 min and stored frozen until analyzed for
      testosterone using established radioimmunoassay procedures. Although LH and HCG
      caused slight increases in testosterone production the amounts produced were much
      less than that produced by rabbit follicles under identical conditions. However,
      when follicles were incubated for a total of 8 h without removal of media, marked
      changes in testosterone and estradiol production occurred. These data suggest
      that the ovarian follicles of the estrous cat are steroidogenically active.

PMID- 1033907
TI  - The use of 8-anilino-1-naphthalenesulfonic acid as a reporter group molecule for
      circular dichroism and fluorescence measurements. The effect of stearic acid and
      sodium dodecylsulfate on the conformation of bovine and human serum albumin.
AB  - The fluorescence probe ANS(8-anilino-1-naphthalenesulfonic acid) was employed as
      a reporter group molecule for circular dichroism and fluorescence measurements in
      order to investigate the effects of stearic acid and sodium dodecylsulfate on the
      conformation of bovine and human serum albumin. Stearate as well as
      dodecylsulfate displaces ANS from the binding to both albumins. Besides this
      displacement, stearate and dodecylsulfate influence the fluorescence properties
      and the extrinsic Cotton effects on ANS bound to both albumins. It is suggested
      that the origin of these effects is a microdisorganization of the albumin
      structure, provoked by the binding of stearate and sodium dodecylsulfate. Each of
      the four extrinsic CD bands of bound ANS was influenced in a different manner by
      the addition of stearate and dodecylsulfate. Using the data of the fluorescence
      measurements and of the circular dichroism measurements it was possible to
      differentiate the effects of one ligand on both albumins and of both ligands on
      one albumin more efficiently than would have been possible using one of the two
      methods alone. It is suggested that the use of ANS as a reporter group molecule
      for fluorescence and circular dichroism measurements is a very good tool to
      detect small changes in the environment of ligand binding sites on protein
      molecules.

PMID- 1033908
TI  - Abnormal behaviour of proline in the isothiocyanate degradation.
AB  - It has been observed that proline residues often initiate overlaps during
      sequenator analysis. The cause has been shown to be an abnormally slow cleavage
      reaction. The kinetics of the cleavage reaction has been studied and found to
      obey pseudo-first-order kinetics. There are considerable differences in reaction
      rates depending on the position of proline in the sequence, as demonstrated for
      the four prolines in the N-terminal section of the H2B histone from chicken.

PMID- 1033909
TI  - Activity of nuclear DNA-dependent RNA polymerases in mouse limb buds
      differentiating in vivo or in organ culture.
AB  - 1) A method was developed to measure the activity of DNA dependent RNA polymerase
      reactions I (alpha-amanitin-insensitive) and II (alpha-amanitin-sensitive) in
      homogenates of very small amounts of tissue. This technique was used to study the
      activity of these polymerase reactions in limb buds from mouse embryos developing
      in vivo or in an organ culture system. This culture system allows the
      morphogenetic differentiation of limb buds in early stages of embryonic
      development (day 10-11 of gestation greater than or equal to 37 - 45 pairs of
      somites) from a blastema stage to well recognizable cartilaginous bone analgen.
      2) An increase in the activities of both types of RNA polymerases was found to
      occur in vivo in limb buds on day 12 of gestation when compared with the activity
      measured on day 11 of gestation. A similar increase with a maximum about 24-48h
      after initiation of the cultures could be observed in the explants
      differentiating in organ culture. To our knowledge this is the first time that
      induction processes proceeding in mammalian embryonic tissues could be correlated
      with an increased activity of RNA polymerases. 3)A rough estimate shows that the
      rate of transcription due to RNA polymerase I measured in homogenates or in
      isolated nuclei (measured with substrate concentrations giving about 80% of the
      maximal rate) would account for the assumed rate of rRNA synthesis in vivo. The
      measurement of the RNA polymerase activity in isolated nuclei, thus, may give
      some information about the transcriptional processes occurring under
      "physiological" conditions. 4) The mammalian organ culture system presented
      provides a suitable model for studying embryonic differentiation processes.

PMID- 1033910
TI  - Identification of the acid-stable trypsin-plasma inhibitors of the human and
      bovine serum as Kunitz-type inhibitors. Preliminary sequencing data.

PMID- 1033911
TI  - Cysteine residues mark the C-terminal triple-helical/non-triple-helical junction
      in type III collagen.

PMID- 1033912
TI  - Constitutional chromosomal breakage.
AB  - There were 18 individuals found to have a constitutional chromosome fragility
      causing an increase in break frequency. For each chromosome the breakpoint is
      always the same, whether it involves chromosomes from the same person, the same
      family, or different families. The fragile points are bands 10q24, 12q13, 16q21,
      17p12, and Xq27. Autosomal constitutional fragility does not seem to have a
      phenotypic correspondence. They were found mostly in parents of children with
      chromosomal abnormalities or in couples with a history of repeated spontaneous
      abortions which permits one to raise the possibility of an interchromosomal
      effect. The six constitutional chromosomal fragilities of the X chromosome had in
      common the association of mental deficiency, delayed speech, and large malformed
      ears. The break points in constitutional chromosomal fragility were compared to
      those of spontaneous breaks in vitro, to those induced by X-rays, and to those in
      Fanconi's anemia. The theoretical  consequences of these structural abnormalities
      are discussed as well as what to do about them when they are found.

PMID- 1033913
TI  - Analysis of volatile N-nitroso compounds by combined gas chromatography and
      thermal energy analysis.

PMID- 1033914
TI  - Volatile nitrosamines in fried bacon.
AB  - Higher levels of NPy and NDMA in cooked bacon and its cooked-out fat were
      associated with those cures which contained higher levels of nitrite, but no
      correlation between nitrosamine concentrations and initial nitrate levels was
      observed. There was a higher proportion of nitrosamines in cooked-out fat than in
      cooked bacon, but by far the greatest amounts were lost in the vapours produced
      during cooking.

PMID- 1033915
TI  - Determination of eight volatile nitrosamines in thirty cured meat products with
      capillary gas chromatography-high-resolution mass spectrometry: the presence of
      nitrosodiethylamine and the absence of nitrosopyrrolidine.
AB  - Five samples each of six cured meat products were analysed for the presence of
      eight volatile nitrosamines. A combined steam distillation-extraction step at pH
      8-9 plus a concentration step were used for preparation of extracts. These were
      analysed, without further clean-up, using a coupled capillary GC-HRMS system at a
      resolution of 4 000. The MS was used in the fixed mass mode, but after the
      retention time of each nitrosamine the mass adjustment was tuned to the mass of
      the next nitrosamine. This combination allowed not only an unambiguous
      identification of the nitrosamines but also their direct quantitative
      determination. The products investigated were cooked ham, fermented sausage, raw
      bacon, mildly fried bacon, fried minced mean and smoked meat. Only one
      nitrosamine, NDEA, was sometimes found to be present in relatively large amounts.
      It occurred in two of the bacon samples; the concentration increased during mild
      frying from 4 and 13 mug/kg to 16 and 43 mug/kg, respectively. It was also
      present in two of the smoked meat samples in amounts of 7 and 91 mug/kg,
      respectively. Its identity was further confirmed on a second and third capillary
      column also coupled to the MS, and by direct introduction of the extracts into
      the MS at a resolution of 15 000. A silicon compound with practically the same
      retention time and mass as NDMA, which originates from the antifoam agents used
      as shown by other investigators, was found in the extracts in amounts
      corresponding to abuot 2 mug/kg of product. Nevertheless, seven samples were
      found positively to contain NDMA in amounts of 2-6 mug/kg. NMEA, NMPA, NMBA and
      NDPA could not be detected in any of the samples, nor could NPip or NPy. That no
      NPy (i.e., less than 50 mug/kg) was found in the fried bacon samples may be due
      to the mild frying method used. The use only of capillary GC with a nitrogen
      selective detector, without further sample clean up, would have led to many false
      positive results due to the presence of other nitrogen-containing compounds.

PMID- 1033916
TI  - Nitrosamines in cured meat products.
AB  - One hundred samples of specially selected spiced meat products (sausages, salami,
      bologna, wieners, meat loaf, canned luncheon mean, etc) were analysed for
      nitrate, nitrite and volatile nitrosamines. None of the samples contained high
      levels of nitrosamines, but many contained traces, generally in the range from 2
      50 mug/kg. Some contained as many as four nitrosamines, namely, NDMA, NDEA, NPip
      and NPy. In a few cases the samples were reanalysed after two weeks' storage at 4
      or -20 degrees C, but no significant change in the nitrosamine levels could be
      detected. The identity of the nitrosamines was confirmed by GLC-high-resolution
      MS.

PMID- 1033917
TI  - Quantitative and qualitative determination of some volatile nitrosamines in
      various meat products.

PMID- 1033918
TI  - Identification and quantitative determination of nitrosoproline and
      nitrososarcosine and preliminary investigations on nitrosohydroxyproline in cured
      meat products.
AB  - A method for the quantitative determination of certain nonvolatile N-nitrosoamino
      acids has been developed. After a clean up procedure, using liquid-liquid
      extraction and ion exchange separation, the nitrosoamino acids are determined
      either by GC after conversion to their methylesters or by photolysis and
      subsequent determination of formed nitrite ion. Identification is made by GC-MS.
      Nitrosoproline and nitrososarcosine can be determined unambiguously; work on
      nitrosohydroxy-proline is in progress. Analysis of some cured meat products has
      shown that nitrosoproline may be present in relatively large amounts (340-440
      mug/kg, confirmed by GC-MS) as compared to the amounts of volatile in
      notrosamines commonly found in these products. A trace of nitrososarcosine (about
      10 mug/kg) was found in one product.

PMID- 1033919
TI  - The relation between the determinable quantities of volatile N-nitroso compounds
      and the peroxide number in soya bean oil.
AB  - Comparative studies of soya bean oil with and without addition of N-nitroso
      compounds (NDMA and NDEA) at different hydroperoxide concentrations have shown
      that the determinable quantities of substances having the retention time of N
      nitroso compounds in soya bean oil and of nitrosoamines added to the oil are
      dependent upon the peroxide number. The determination was carried out by gas
      chromatography (nitrogen detector, nitrogen-sensitive, flame-ionization detector)
      prior to and following irradiation with UV light (360 nm). When the peroxide
      number was above 4, the determinability and the recovery were reduced by more
      than 60 per cent. In advanced autoxidation and after reduced recoveries, large
      amounts of NMDA and NDEA may be encountered for a short time. A possible linkage
      between N-nitroso compounds and peroxide is discussed. Comparative investigations
      of soya beans, crude oil, intermediates and commercially available steamed oils
      have revealed that the concentrations of the compounds with NDMA and NDEA
      properties in crude oil (peroxide number about 3) is higher than in soya beans.
      The recovery of these compounds is very poor in intermediate products with high
      peroxide numbers (about 5 to 9). However, N-nitroso compounds can be demonstrated
      in commercially available oils treated with steam (peroxide number about 0.7),
      although to a lesser extent than in crude oil.

PMID- 1033920
TI  - Nitrosamines and their precursors in some Estonian foodstuffs.

PMID- 1033921
TI  - Reduction of nitrosodimethylamine content in Cantonese salt fish.

PMID- 1033922
TI  - Group evaluation of volatile and nonvolatile N-nitroso compounds in foodstuffs.

PMID- 1033923
TI  - Techniques for the screening of foodstuffs for volatile nitrosamines.

PMID- 1033924
TI  - Malnutrition, humoral immunity and infection.

PMID- 1033925
TI  - Public interest report No. 20--Why shouldn't providers and consumers (older
      people and their families) join together in an alliance for older people?

PMID- 1033926
TI  - Incorporation of U-[14C]-lysine into p=otein, and DNA, RNA, protein and glycogen
      contents in the uterus of heat-acclimatized rats during the estrous cycle.

PMID- 1033927
TI  - Lissencephaly in Lhasa Apso dogs.

PMID- 1033928
TI  - Prevalence of Toxoplasma infection in cattle slaughtered at an Ohio abattoir.
AB  - Specimens of heart, diaphragm and, in 159 instances, esophagus were taken from
      352 cattle slaughtered in an Ohio abattoir. The total weight of the material was
      32 kg, and this was fed to 12 specific-pathogen-free cats to test for Toxoplasma
      infectivity. None of the 12 cats acquired Toxoplasma infection, as evidenced by
      their failure to excrete oocysts or to develop antibodies, and by failure to
      isolate Toxoplasma from their tissues by inoculation into mice. In further tests,
      a 650-g sample of beef from 77 of the 352 cattle was digested in 1% trypsin, then
      inoculated intraperitoneally into 40 mice. Toxoplasma was not isolated from the
      mice. Serums from 186 of the 352 cattle were inactivated at 60 C for 1 hour, then
      examined by the Sabin-Feldman (dye) test for antibodies to Toxoplasma. None had
      titers of more than 1:8. Of the 186 serums, 77 were also examined for antibodies
      in the indirect hemagglutination test. One had a titer of 1:64, which was
      considered nonspecific. Thus, evidence for Toxoplasma infection was not found in
      352 cattle.

PMID- 1033929
TI  - A serologic survey of a population of Georgia dogs for Brucella canis and an
      evaluation of the slide agglutination test.
AB  - In a serologic survey of stray and pet dog populations of Georgia, serums were
      screened for Brucella canis antibodies, using the slide agglutination test. If
      results were positive, B canis antibody titers were determined, using the
      standard tube agglutination test. The stray dogs had significantly (P less than
      0.01) higher titers than did the pet dogs. The reactor rate was 58% higher for
      the slide agglutination test than for the tube agglutination test. The
      manufacturer's  evaluation of the slide agglutination test was based on a
      comparison of the serologic results of that test with those of the tube
      agglutination test, using a comparative method that permitted the results to be
      interpreted as 99% agreement between the 2 tests. Reevaluation of the
      manufacturer's data by a different method indicated that the slide agglutination
      test is very accurate when the results are negative (99.7% specific) but less so
      when the results are positive (62.5% sensitive).

PMID- 1033930
TI  - Adiaspiromycosis in the lungs of a dog.

PMID- 1033931
TI  - Evaluation of a modified water-deprivation test for diagnosis of polyuric
      disorders in dogs.
AB  - A modified water-deprivation test was performed on 12 polyuric and 4 clinically
      normal dogs. Immediately after maximal urine osmolality had been achieved with
      water deprivation, antidiuretic hormone was injected to test further renal
      concentrating ability. The test provided accurate diagnosis of severe
      hypothalamic-neurohypophyseal diabetes insipidus in 3 dogs, partial diabetes
      insipidus in 2 dogs, and primary (psychogenic) polydipsia in 2 dogs. Five
      polyuric dogs with hyperadreno corticism had a response to the modified water
      deprivation test similar to that of dogs with partial diabetes indipidus.

PMID- 1033932
TI  - Scanning electron microscopy of the endometrium during the secretory phase.
AB  - Scanning electron microscopy was used to study the surface morphology of the
      rabbit endometrium during the secretory phase of the oestrous cycle. The free
      surfaces of ciliated and of inactive active secretory cells are described.
      Changes in secretory cell surface morphology resulting from accumulation and
      secretion of material involve the apparent retraction of microvilli and the
      formation of one or more bulbous protrusions of the cell's apical surface. These
      protrusions may be relatively smooth surfaced or exhibit long  slender micro
      extensions. The protrusions grow in size and are eventually pinched off. Loss of
      the bulbous protrusions often leaves behind crater-like invaginations of the
      cell's surface. Secretory cells adjacent to the endometrial glands are the first
      to exhibit signs of mucin accumulation and secretion. The single cilium of a
      secretory cell is not apparently affected by the secretory process. Signs of
      ciliated and secretory cell degeneration, and possible sloughing, are also
      described.

PMID- 1033933
TI  - Genetic influence on normal variability of maximum expiratory flow-volume curves.
AB  - To determine the importance of genetic influence on the variability of maximum
      expiratory flow-volume (MEFV) curves in normal individuals, MEFV curves breathing
      air and a mixture of 80% helium and 20% oxygen (He-O2), lung volumes, specific
      airway conductance, and closing capacity (CC) were obtained in 10 pairs of
      identical and 6 pairs of nonidentical twins, all nonsmokers and asymptomatic. For
      a given pair of identical twins, MEFV curves on air were more similar than those
      of a pair of nonidentical twins (P less than 0.02). The intrapair differences of
      identical twins were smaller than nonidentical twins of maximum expiratory flow
      (Vmax) at 60% of total lung capacity (TLC) on air (P less than 0.001) and on He
      O2 (P less than 0.01). However, intrapair differences of Vmax at 40% TLC and CC
      were not significantly different in the two groups. Since Vmax at 60% TLC on air
      and He-O2 are dependent on the geometry of large airways these findings are
      suggestive that the geometry of large airways may be related to genetic factors.
      The relationship of the geometry of the peripheral airways and genetic factors
      has not been defined.

PMID- 1033934
TI  - Molecular weight estimation of protoheme ferro-lyase by radiation inactivation.
AB  - The molecular weight of protoheme ferro-lyase [EC 4.99.1.1], a mitochondrial
      enzyme, was estimated by the radiation inactivation method. Irradiation in vacuo
      caused less inactivation than that in air. The approximate molecular weight
      determined by this method was in the range from 250,000 to 320,000. The
      significance of the location of the enzyme in connection with its role in heme
      synthesis is discussed on the basis of Singer's membrane theory.

PMID- 1033935
TI  - Biosynthesis of glycosphingolipids in cultured mouse neuroblastoma cells.
      Precursor-product relationships among sialoglycosphingolipids.
AB  - The reaction sequence for the biosynthesis of gangliosides by mouse neuroblastoma
      cells has been investigated by studying the pattern of incorporation of labeled
      precursors into sialoglycosphingolipids. Cultured NB41A cells incorporated N
      [3H]acetylmannosamine into the sialic acid moiety of GM3 in less than 10 min.
      Labeled GM2 was not detected in cells incubated for less than 30 min, while
      measurable radioactivity did not appear in GM1 until after 60 to 90 min.
      Analogous experiments were carried out using [14C]galactose. No significant
      amount of labeled hexose was incorporated into asialo-GM2 during 60 min of
      culture. These studies are in accord with results of previous studies on
      glycosyltransferases of NB41A cells (Kemp, S. F., and Stoolmiller, A. C. (1976),
      J. Neurochem. 26, 723-732), and further support the concept that the pathway of
      synthesis of gangliosides proceeds via GM3 leads to GM2 leads to GM1.

PMID- 1033936
TI  - The zygosity of twins: further evidence on the agreement between diagnosis by
      blood groups and written questionnaires.

PMID- 1033937
TI  - Conformational constraints in nuclear DNA.
AB  - We have investigated DNA superstructure in a wide range of nuclei of higher cells
      by gently lysing cells to release structures that resemble nuclei but are
      depleted of nuclear proteins. The sedimentation properties of these structures,
      which we call nucleoids, have been examined in sucrose gradients containing the
      intercalating agent, ethidium. The sedimentation rate of nucleoids derived from
      the growing cells of mammals, birds, amphibians and insects varies in the manner
      characteristic of circular and superhelical molecules of DNA. These
      characteristic changes in sedimentation rate are abolished by irradiating the
      nucleoids with low doses of gamma-rays, a procedure known to introduce single
      strand scissions into DNA. We have also investigated by similar means DNA
      superstructure in nucleoids derived from a variety of different chick cells.
      Nucleoids derived from adult hen erythrocytes differ from the other nucleoids
      studied in that their sedimentation rate does not vary in the manner
      characteristic of supercoiled DNA.

PMID- 1033938
TI  - Ultrastructural studies on the surface membrane of the mouse egg.
AB  - Fertilized and unfertilized mouse eggs were examined by scanning and transmission
      electron microscopy for evidence of mosaicism in the organization and
      concanavalin A-binding properties of their surface membranes. No obvious
      quantitative mosaicism in concanavalin A binding was noted. The egg membrane was
      microvillous over most of its surface, but was smooth in the region overlying the
      2nd metaphase spindle of the unfertilized egg and on the polar body of the
      fertilized egg.

PMID- 1033939
TI  - Contacts between pigmented retina epithelial cells in culture.
AB  - The behaviour of primary cultures of dissociated embryonic chick pigmented retina
      epithelial (PRE) cells has been investigated. Isolated PRE cells have a mean
      speed of locomotion of 7-16 mum/h. Collisions between the cells normally result
      in the development of stable contacts between the cells involved. This leads to a
      gradual reduction in the number of isolated cells and an increase in the number
      of cells incorporated into islands. Ultrastructural observations of islands of
      cells after 24 h in culture show that junctional complexes are present between
      the cells. These complexes consist of 2 components: (a) an apically situated
      region of focal tight junctions and/or gap junctions, and (b) a more ventrally
      located zonula adhaerens with associated cytoplasmic filaments forming a band
      running completely around the periphery of each cell. The intermembrane gap in
      the region of the zonula is 6-0-12-0 nm. The junctional complexes become more
      differentiated with time and after 48 h in culture consist of an extensive region
      of tight junctions and/or gap junctions and a more specialized zonula adhaerens.
      It is suggested that the development of junctional complexes may be responsible
      for the stable contacts that the cells display in culture.

PMID- 1033940
TI  - Bromination products of 2,4-dimethyl-1,5-benzodiazepine.

PMID- 1033941
TI  - Some derivatives of 2- and 3-phenylthiophen.

PMID- 1033942
TI  - Synthesis and crystal and molecular structure of a 1,11-methano-steroid, 3
      methoxy-1'beta-methyl-1,11alpha-methano-9beta-estra-1,3,5(10)-trien-17beta-ol.

PMID- 1033943
TI  - Syntheses of isoalloxazines, alloxazines, toxoflavins, and Fervenulins by
      oxidative cyclization of the Michael-type adducts from substituted 6-Aminouracils
      and Azo-compounds.

PMID- 1033944
TI  - Structures of three new C16 terpenoids from an Acrostalagmus fungus.

PMID- 1033945
TI  - Mechanism of aromatic hydroxylation in fungi. Evidence for the formation of arene
      oxides.

PMID- 1033946
TI  - Derivatives of hydroxyquinol. Part 4. A synthesis of di-O-methylcitromycin;
      Electronic effects in hydroxyquinol derivatives.

PMID- 1033947
TI  - Determination of biogenic amines in intestinal contents by ion-exchange
      chromatography.

PMID- 1033948
TI  - Preferential binding of testosterone over epitestosterone by human plasma.
AB  - The main purpose of this study was to investigate if the specificity of the
      binding of testosterone to plasma proteins could be defined as a preferential
      binding of this steroid over epitestosterone. The amount of testosterone that is
      specifically bound was calculated using the formula: (see article) concentration,
      where "Ri" is the ratio (14C) testosterone: (3H) epitestosterone in plasma prior
      to centrifugation, "Ru" is the isotope ratio in the protein-free supernatant
      obtained after ultracentrifugation (149,000 x g, at 0 C, for 18 h) and "T
      concentration" is the testosterone concentration in plasma resulting from
      addition of (14C) testosterone, the endogenous steroids having been removed by
      preliminary charcoal extraction. The theoretical separation of the binding sites
      for testosterone into two populations, one non-specific with no preference for
      testosterone over epitestosterone, and another with absolute specificity for
      testosterone over its physiologically inactive stereoisomer, proved to be useful.
      Ovalbumin was found to be an example for non-specific, non-preferential binding.
      Determination of the ratio (14C) testosterone: (3H) epitestosterone in the
      successive fractions of various ultracentrifuged preparations showed a small but
      significant preference for (14C) testosterone by human and bovine serum albumin,
      while alpha1-acid glycoprotein had a preference for (3H) epitestosterone.
      Saturation curves showed at least two components: the first one, presumably
      corresponding to TeBG, had a higher affinity and lower capacity. This binding
      capacity can be accurately determined by extrapolation to the ordinate or the
      second component, a straight line corresponding to a binding of somewhat lower
      affinity and much larger capacity.

PMID- 1033949
TI  - Somatomedin in cord blood: relationship to gestational age and birth size.
AB  - Somatomedin (SM) was determined by bioassay in cord blood from 100 neonates born
      at 24-42 weeks of gestation and from three infants with major congenital
      malformations. SM levels rose with gestational age and had a positive correlation
      with birth weight, length and head circumference independantly of gestational
      age. These findings suggest a relationship between somatomedin and fetal growth.

PMID- 1033950
TI  - Major proteins of soybean seeds. A straightforward fractionation and their
      characterization.

PMID- 1033951
TI  - Nitrosopyrrolidine formation in fried bacon.

PMID- 1033952
TI  - Automated determination of tryptophan in legumes and cereals.

PMID- 1033953
TI  - Heat-induced complex formation between myosin and soybean 7S globulins.

PMID- 1033954
TI  - Natural occurrence of alternariols in discolored pecans.

PMID- 1033955
TI  - Schistoma mansoni soluble egg antigens: determination of the stage and species
      specificity of their serologic reactivity by radioimmunoassay.
AB  - Three highly purified Schistosoma mansoni egg antigens reactivity with sera from
      mice with chronic schistosomiasis mansoni (major serologic antigens-MSA1, MSA2,
      and MSA3) were utilized in radioimmunoassays for determining their stage and
      species specificity. Inhibition studies revealed that MSA1 was completely stage
      specific, since its binding to S. mansoni chronic infection serum (CIS) could not
      be inhibited either with cercarial or adult worm antigen. MAS2 and MSA3 were
      specific with regard to adult worm antigen but their binding to CIS was slightly
      inhibited by cercarial antigen. Immature eggs in comparison with mature eggs
      contained only negligible amounts of MSA1 whereas MSA2 and MSA3 were present in
      large quantities. Fluid from eggs hatched in spring water (hatch fluid-HF)
      contained considerable amounts of MSA1 as well as MSA2 and MSA3. With regard to
      species specificity, MSA1 essentially did not cross-react with crude soluble egg
      antigen (SEA) from Schistosoma japonicum and Schistosoma haematobium whereas MSA2
      and MSA3 showed partial cross-reactivity. Antibody dilution studies with sera
      from animals and humans infected with heterologous schistosome species (i.e., S.
      japonicum and S. haematobium) indirectly confirmed the high degree of species
      specificity of MSA1. The degree of serologic specificity of MSA1 as demonstrated
      in this study parallels that of the sensitizing activity of S. mansoni eggs and
      SEA for granuloma formation, as demonstrated in previous investigations. This
      study, therefore, indicates that MSA1 may be a major immunopathologically active
      egg antigen. In addition, the high degree of species specificity of MSA1 suggests
      its use in the serodiagnosis of schistosomiasis mansoni.

PMID- 1033956
TI  - The in vitro permeability of skin and buccal mucosa to selected drugs and
      tritiated water.
AB  - The permeability of whole human skin, human dermis, whole pig skin, and canine
      buccal mucosa have been determined for four chemically different solutes:
      tritiated water, amphetamine, estradiol, and ouabain. Several new in vitro
      techniques for isolation, preservation, and permeability determination of these
      membranous tissues are described. Water permeabilities of human epidermis and
      dermis using these techniques agree well with published results. Human and
      porcine skins are very similar with respect to water permeability, while buccal
      mucosa is similar to dermis in its permeability characteristics to the four
      representative test agents. The permeability of hydrated whole skin is determined
      by the permeability of the epidermis, and the dermis and buccal mucosa behave as
      if they are water barriers exhibiting a permeability of about 30% of the
      diffusion through pure water, a difference that can be ascribed to the porosity
      and/or tortuosity of the tissue matrix.

PMID- 1033957
TI  - [Clinical studies on the corrective surgery of single ventricle associated with
      transposition of great vessels].

PMID- 1033958
TI  - [ECG studies of patients' own rhythms with chest wall stimulation method during
      permanent pacing].

PMID- 1033959
TI  - [Surgical management of the tricuspid valve--follow-up studies of valve
      replacement and annuloplasty].

PMID- 1033960
TI  - [Aorto-pulmonary artery shunt with a homograft vein--experimental studies].

PMID- 1033961
TI  - [Decrement of heart function by the injection of contrast media during coronary
      arteriography].

PMID- 1033962
TI  - [Long-term extracorporeal circulation and the prognosis].

PMID- 1033963
TI  - [Right ventricular outflow reconstruction with heart valve and vascular
      prostheses].

PMID- 1033964
TI  - [Excision of left ventricular aneurysm and large scarred myocardium following
      myocardial infarct. Postoperative and follow-up studies based on hemodynamics and
      left ventricular function].

PMID- 1033965
TI  - [Etiological and clinical studies of chronic pancreatitis].

PMID- 1033966
TI  - [Study on insulin binding antibody in diabetics (author's transl)].

PMID- 1033967
TI  - [Myxedema with a huge pericardial effusion and cardiac tamponade (author's
      transl)].

PMID- 1033968
TI  - [A case of systemic lupus erythematosus with subarachnoideal bleeding (author's
      transl)].

PMID- 1033969
TI  - [Hepatic coma (author's transl)].

PMID- 1033970
TI  - [Pathophysiology of molecular diseases. In special reference to abnormal
      hemoglobin (author's transl)].

PMID- 1033971
TI  - [Experimental and clinical studies on coronary vascular reserve (author's
      transl)].

PMID- 1033972
TI  - [A case of destructive chondroarthropathy (author's transl)].

PMID- 1033973
TI  - [Two cases of Cushing's disease with sudden remission after an episode of
      hysteria or administration of reserpine-metyrapone (author's transl)].

PMID- 1033974
TI  - [Two cases of left atrial myxoma with different findings and features (author's
      transl)].

PMID- 1033975
TI  - [A case of acute renal failure caused by exertional myoglobinuria (author's
      transl)].

PMID- 1033976
TI  - Leptospirosis australis--a case report.

PMID- 1033977
TI  - Plasma concentration of androstenedione during the bovine oestrous cycle.
AB  - A radioimmunoassay with Sephadex chromatography for androstenedione is described.
      Concentrations of androstenedione in bovine peripheral blood during the oestrous
      cycle ranged from 80 to 100 pg/ml. There was considerable variation and no
      pattern suggestive of physiological significance emerged, unlike those of
      oestradiol and testosterone.

PMID- 1033978
TI  - Changes in uterine and ovarian blood flow during the oestrous cycle in rats.
AB  - The rates of uterine and ovarian blood flow during the oestrous cycle in rats
      were measured using radioactive microspheres. Blood flow was highest in the
      ovaries and uteri during pro-oestrus and lowest during metoestrus. During pro
      oestrus, mean ovarian blood flow was 676-2 +/- 183-6 (S.D.) ml/min/100 g wet
      tissue and mean uterine blood flow was 249-7 +/- 120-1 ml/min/100 g. During
      metoestrus mean ovarian blood flow was 117-4 +/- 19-8 ml/min/100 g and mean
      uterine blood flow was 38-5 +/- 7-4 ml/min/100 g. In ovariectomized rats, uterine
      blood flow was 28-7 +/- 10-5 ml/min 100 g.

PMID- 1033979
TI  - Variables affecting establishment of schedule-induced attack on pictorial targets
      in White King pigeons.
AB  - White King pigeons exposed to food schedules before introduction of a colored
      photograph of a pigeon showed sustained schedule-induced attack on that image;
      additional birds given an early introduction to both the photograph and the
      schedule subsequently attacked the image at lower rates. Other pigeons attacked a
      second photograph of a pigeon regardless of whether it was introduced early or
      late. The late-introduction procedure was also effective in establishing attack
      on a projected image of a conspecific. The combined results showed that 14 of 17
      White King pigeons given a late introduction to a pictorial target exhibited
      sustained attack against it and that a pigeon's initial reaction to a photograph
      of a conspecific when introduced early was a good predictor of subsequent
      schedule-induced attack on it.

PMID- 1033980
TI  - Developmental aspects of secondary palate formation.
AB  - Research on development of the secondary palate has, in the past, dealt primarily
      with morphological aspects of shelf elevation and fusion. The many factors
      thought to be involved in palatal elevation, such as fetal neuromuscular activity
      and growth of the cranial base and mandible, as well as production of
      extracellular matrix and contractile elements in the palate, are mostly based on
      gross, light microscopic, morphometric or histochemical observations. Recently,
      more biochemical procedures have been utilized to described palatal shelf
      elevation. Although these studies strongly suggest that palatal extracellular
      matrix plays a major role in shelf movement, interpretation of these data remains
      difficult owing to the complexity of tissue interactions involved in craniofacial
      development. Shelf elevation does not appear to involve a single motive factor,
      but rather a coordinated interaction of all of the abovementioned developmental
      events. Further analysis of mechanisms of shelf elevation requires development of
      new, and refinement of existing, in vitro procedures. A system that enables one
      to examine shelf elevation in vitro would allow more meaningful analysis of the
      relative importance of the various components in shelf movement. Much more is
      known about fusion of the palatal shelves, owing in large part to in vitro
      studies. Fusion of the apposing shelves, both in vivo and in vitro, is dependent
      upon adhesion and cell dealth of the midline epithelial cells. Adhesion betweeen
      apposing epithelial surfaces appears to involve epithelial cell surface
      macromolecules. Further analysis of palatal epithelial adhesion should be
      directed towards characterization of those cell surface components responsible
      for this adhesive interaction. Midline epithelial cells cease DNA synthesis 24-36
      h before shelf elevation and contact, become active in the synthesis of cell
      surface glycoproteins, and subsequently manifest morphological signs of necrosis.
      Death of the midline epithelial cells is thought to involve a programmed,
      lysosomal-mediated autolysis...

PMID- 1033981
TI  - Biosynthesis of DNA, RNA and proteins by mouse embryos cultured in the presence
      of a teratogenic dose of chlorambucil.
AB  - The effect of chlorambucil on the rates of DNA, RNA, and protein synthesis in
      mouse embryos was investigated using a system of whole embryo culture. Embryos
      were isolated on the 11th day of gestation (33 +/- 3 somites) and grown in
      culture media for periods of 4-8 h. Reichert's membrane and most of the placental
      tissue was removed leaving only the amnion and visceral yolk-sac surrounding the
      embryo. In the presence of teratogenic doses of chlorabucil (15 mug/ml) the rate
      of DNA synthesis was significantly decreased at 4 and 8 h. RNA and protein
      synthesis were not inhibited at either of these times. A trend toward decreasing
      rates of protein synthesis at some time beyond 8 h was noted, but not tested.

PMID- 1033982
TI  - Postimplantation development of blastomeres isolated from 4- and 8-cell mouse
      eggs.
AB  - Blastomeres isolated from 4- and 8-cell mouse eggs were inserted into empty zonae
      and transferred to the oviduct. The products of both types of blastomere were
      capable of inducing decidual formation. One implant produced by an isolated
      blastomere from a 4-cell egg contained a small, retarded embryo at 5 1/2 days but
      most decidua from blastomeres of either 4- or 8-cell eggs contained only a few
      trophoblast giant cells. It is suggested that this lack of totipotency is due to
      insufficient cells being present at cavitation rather than restriction in
      developmental potential.

PMID- 1033983
TI  - The permeability to cytochalasin B of the new unpigmented surface in the first
      cleavage furrow of the newt's egg.
AB  - Two of 10 mug/ml cytochalasin B (CB) caused retraction of the first cleavage
      furrow in Triturus eggs, a spreading of the unpigmented surface from the furrow
      region and a flattening of the whole egg. CB appears to act against the
      contractility of the microfilamentous band at mid-cleavage so as to relax the
      furrow and also to weaken unpigmented surface to allow the egg to flatten.
      Uncleaved eggs and the initial formation of the cleavage groove were unaffected
      by CB. A fully-retracted first cleavage furrow reformed itself on transfer of the
      egg to normal medium but only at the time of second cleavage. Initiation of
      second cleavage depended upon there being sufficient of the original pigmented
      surface on the animal hemisphere. Tritium-labelled CB of high specific activty
      was prepared and used to study its ability to penetrate the surface of newt eggs
      during cleavage. Scintillation couting of whole eggs showed that CB was not taken
      into the newt egg until mid-cleavage (about 17 min after the double stripe stage)
      when new surface began to spread in the cleavage furrow. Fixation in
      glutaraldehyde and osmium tetroxide retained radioactivity in the egg, but more
      CB was retained after fixation in osmium tetroxide alone than after double
      fixation. Most of the retained radioactivity was in yolk platelets.
      Autoradiographs were prepared to sectioned eggs which had been fixed at late
      cleavage after [3H]CB had flattend the furrow. These showed that CB entered the
      egg through the unpigmented surface which formed in the furrow but it could not
      enter through the pigmented surface. The impermeability of the pigmented surface
      explains the observations that CB does not prevent initial furrowing at cleavage.
      Once inside the egg CB is transported slowly. CB penetrates to a limited extent
      beneath the pigmented surface from its border with the unpigmented surface in the
      first cleavage furrow and this seems insufficient in some circumstances to
      suppress the contractile phase of second cleavage.

PMID- 1033984
TI  - The developmental analysis of an embryonic lethal (C6H) in the mouse.
AB  - A development study of the effects of the C6H allele at the albino locus has
      identified the C6H homozygote as an early postimplantation lethal. Homozygous C6H
      embryos can first be recognized at 6 1/2-7 days of gestation by abnormalities of
      the ectoplacental and parietal endodern. At 7 1/2 days, mutant embryos appear
      severely retarded with obvious abnormalities in all germ layers. All C6H
      homozygotes are dead and resorbed by 8 days of development. It is proposed that
      the mutation interferes with the normal differentiation of the parietal endoderm,
      ectoplacental cone and extra-embryonic ectoderm of the egg cyclinder.

PMID- 1033985
TI  - Experiments on blocking and unblocking of first meiotic metaphase in eggs of the
      parthenogenetic stick insect Carausius morosus Br. (Phasmida, Insecta).
AB  - The eggs of the parthenogenetic stick insect Carausius morosus, which remain
      arrested in first meiotic metaphase until oviposition, must be activated in order
      to develop. The activating agent is oxygen from the air, which enters the egg
      cell through the micropyle. An exposure shorter than one minute is sufficient to
      release the blockage. In non-activated (micropyle-less) eggs the first metaphase
      chromsomes either degenerate or change into an interphase nucleus. This nucleus
      polyploidizes by endoreduplication, and then either degenerates or multiplies by
      amitosis. Similarly more generations of nuclei may arise resulting in a chaotic
      development. These nuclei survive better in the anterior region of the egg. The
      question of whether the cytoplasmic factors which control nuclear behaviour, also
      operate in eggs of C. morosus is discussed.

PMID- 1033986
TI  - Protein synthesis and germ plasm in cleavage embryos of Xenopus laevis.
AB  - (3H) leucine was injected into unfertilized eggs, fertilized eggs, and Stage 2-12
      embryos of X. laevis. Incorporation of the leucine into protein by blastomeres
      containing germ plasm was studied autoradiographically. Eggs, both fertilized and
      unfertilized, actively synthesized protein, ad did embryos from Stage 2 onwards.
      Probably all blastomerers containing germ plasm were labelled. In embryos from
      Stages 4-12, the germ plasm itself was also labelled, and this result suggests
      that the germ plasm is metabolically active during cleavage.

PMID- 1033987
TI  - Social experience and territorial aggression in rats: a replication with selected
      aggressive males.

PMID- 1033988
TI  - Changes in the striatal adenylate cyclase activity following acute and chronic
      morphine treatment and during withdrawal.

PMID- 1033989
TI  - Structure and function of the glandular vas deferens in Ascaris suum (Nematoda).
AB  - The glandular vas deferens in the linearly arranged male reproductive tract in
      Ascaris suum produces substances which cause marked morphological and
      physiological changes in the spermatozoa. The glandular secretions, presumably
      formed by the rough endoplasmic reticulum and Golgi saccules, are extruded from
      the cells and coalesce to form homogeneous masses in the gland lumen. In sexually
      inactive worms the secretory material is separated from the spermatozoa by a
      sphincter comprised of neuro-muscular-like cells. During copulation the sphincter
      lumen enlarges and the spermatozoa and sperm-activating glandular material are
      mixed and simultaneously transferred to the female worm.

PMID- 1033990
TI  - Thelazia lacrymalis in horses in Kentucky and observations on the face fly (Musca
      autumnalis) as a probable intermediate host.
AB  - Eyes from 114 (30.3%) of 376 dead horses, examined from 3 April 1975 to 3 April
      1976, were naturally infected with adult Thelazia lacrymalis; 1 horse was also
      infected with 1 male Thelazia skrijabini. Adult T. lacrymalis from dead horses
      were successfully transferred mechanically to the eyes of 3 of 4 Shetland ponies
      raised helminth-free. Larvae from gravid female T. lacrymalis underwent
      development in experimentally infected, laboratory-raised face flies (Musca
      autumnalis) and third-stage larvae ranging from 1.82 to 2.94 mm in total length
      were recovered at 12 to 15 days postexposure. A total of 866 naturally occurring
      face flies were collected from the head region of horses. Twelve of the face
      flies harbored larval stages of Thelazia spp. One of the larvae resembled third
      stage T. lacrymalis that were recovered from the experimentally infected,
      laboratory-raised face flies. Introduction of 3 third-stage larvae from 1 face
      fly onto the cornea of a pony raised helminth-free resulted in the recovery of 1
      male T. skrjabini 242 days later. In addition to the eyeworm larvae, other
      parasites recovered from the face flies included Heterotylenchus autumnalis,
      hypopi of astigmatid mites and a first instar beetle (Coleoptera: Rhipiphoridae).
      Data from these investigations indicate the likelihood that face flies are an
      intermediate host for T. lacrymalis and probably other species of Thelazia in
      this part of the country.

PMID- 1033991
TI  - Changes in leadership appraisal as a function of the stress of a simulated panic
      situation.
AB  - Research by Mintz and Kelley, Condry, Dahke, and Hill left unresolved the
      question of what level of personal threat leads to group incoordination of "panic
      behavior." The present study set out to resolve this issue and to explore the
      additional relationship between leadership and behavior in the panic situation.
      The dependent variables were Likert-type questionnaire items designed to
      investigate the level of responsibility attributed to a leader by members of a
      group as a function of four variables: (a) two levels of stress (threat of shock
      or of small monetary loss); (b) two levels of leadership authority (elected or
      appointed); (c) two conditions of leadership ("me-last" or "me-first"); and (d)
      group success or failure. The specific questions were adapted from earlier pilot
      work by Sulzer and Sisti. One hundred and forty-four males were run in this 2 X 2
      X 2 X 2 factorial design with a nonfactorial control group. The task setting,
      which required subjects to retrieve their wooden cones through the same hole, was
      designed to be analogous to the kind of situation that would occur in a theater
      fire where only one narrow exit existed. The results support the contention of
      Kelley that group incoordination (panic) increases under personal threat.
      Additional results were: (a) Leaders facilitated achieving the goal of safe exit;
      (b) elected leaders were given more responsibility and were seen as more
      competent than appointed leaders, but only when the stress is comparatively low,
      as otherwise the difference in evaluation narrows and reverses; and (c) success
      or failure seems to have had little effect on the leader's evaluation by the
      group.

PMID- 1033992
TI  - [Oxidation with Fremy's salt. VI. Syntheses of several 5-alkyl (and phenyl)-1
      naphthols (author's transl)].

PMID- 1033993
TI  - [Physicochemical properties of medicinal agents. IV. Permeability of barbituric
      acid derivatives in absorption simulator (author's transl)].

PMID- 1033994
TI  - [Studies on medicinal resources. XXXVIII. Studies constituents of Polygonatum
      plants (Liliaceae). (1). The constituents in the leaves of Polygonatum odoratum
      (Mill.) Druce var. pluriflorum (Mig.) Ohwi (author's transl)].

PMID- 1033995
TI  - [Analysis of 5-methylcytosine in tRNA by gas chromatography (author's transl)].

PMID- 1033996
TI  - [Studies on packing of powder. VI. Compaction of fine powder (author's transl)].

PMID- 1033997
TI  - [Studies on the constituents of Quercus spp. V. Paraffins and triterpenes of
      Quercus spp. in Japan (author's transl)].

PMID- 1033998
TI  - [Studies on the constituents of Quercus spp. VI. Triterpenes of Quercus glauca
      Thunb., structure of cyclobalanone].

PMID- 1033999
TI  - [Studies on the constituents of Quercus spp. VII. Triterpenes of Quercus gilva
      Blume (author's transl)].

PMID- 1034000
TI  - [On the constituents of the fruits of Rosa multiflora Thunb. II. (author's
      transl)].

PMID- 1034001
TI  - [Growth behaviors and mechanism of caffeine whiskers on the granules (author's
      transl)].

PMID- 1034002
TI  - [On the constituents of the rhizomes of Atractylodes iancea DC var. chinensis
      Kitamura ("Jin-changzhu") and Atractylodes ovata DC ("Chinese baizhu"). The gas
      chromatographic analysis of the crude drug "zhu") (author's transl)].

PMID- 1034003
TI  - [Polymorphism of thiamine hydrochloride (author's transl)].

PMID- 1034004
TI  - [Thiosugars. II. Isomerization of 2,3-dithiohexopyranosides to furanosides
      (author's transl)].

PMID- 1034005
TI  - [Studies on biologically active substances from rabbit skin tissues infected with
      vaccinia virus.--Isolation and properties of inhibitor to gastric acid secretion
      (author's transl)].

PMID- 1034006
TI  - [The selective methylation of xylenes on SiO2-Al2O3 modified with various amines
      (author's transl)].

PMID- 1034007
TI  - [Oxidation with Fremy's salt. VII. Syntheses of several 5-substituted-1-naphthols
      (author's transl)].

PMID- 1034008
TI  - [Syntheses of nitrogen-containing heterocyclic compounds. XXIV. Derivatives of 5
      thiocyanato-6-haloquinaldines (author's transl)].

PMID- 1034009
TI  - Psychophysiological aspects of the menstrual cycle.

PMID- 1034010
TI  - Diurnal variation and individual differences in the perception of intractable
      pain.

PMID- 1034011
TI  - Bio-feedback: opening discussant's remarks after Professor Neal Miller's talk.

PMID- 1034012
TI  - Physiological responsivity of normal and sexually dysfunctional women during
      erotic stimulus exposure.

PMID- 1034013
TI  - [Anatomical and histological approach to the radioraphic appearance of the breast
      (author's transl)].
AB  - The authors present first correlations between histology, anatomy and serial
      radiography of the breast, in order to establish a new understanding of the
      mammographic picture, with respect to the tridimensional histological structures.
      Several essential points are considered: - Mammographic pictures only show
      fibrous, connecting and fatty tissues. The epithelium of the galactophores is not
      shown, because of its low radio-opacity. Mammographic densities are due above all
      to fibrous connecting tissue, which has a high percentage of water. Benign or
      malignant breast tumors present with a proliferation of epithelium and connecting
      tissue, but only connecting tissue, more or less hydrated is shown on the
      mammographic picture. Many mammographic patterns are related to various
      superimposed fibrous strands, appearing as pseudotumoral opacities. The benign or
      malignant tumoral opacities are hidden or modified by multiple superimposed
      adjacent structures. - The mammographic patterns is related to the degree of
      hydratation and components of the connecting tissue.

PMID- 1034014
TI  - Eosinophil-mediated destruction of Schistosoma mansoni eggs.

PMID- 1034015
TI  - Clinical details, cytogenic studies,and cellular physiology of a 69, XXX fetus,
      with comments on the biological effect of triploidy in man.
AB  - A triploid fetus, 69, XXX, aborted spontaneously at 26 weeks' gestation. It had
      multiple abnormalities including syndactyly of the hands and feet single palmar
      creases, hypoplasia of the adrenals and ovaries, hypertrophy of thigh muscles,
      and abnormalities of the brain. The placenta was large and showed hydatidiform
      degeneration. The pregnancy had been complicated by acute dyspnoea, pre
      eclampsia, and postpartum haemorrhage. Detailed cytogenetic studies, using
      banding and fluorescence techniques, were performed on fetus and parents. Meiotic
      studies were made on the fetal ovaries. Muscle cell differentiation and
      electrophysiological relationships of cultured skin fibriblasts were examined in
      an attempt to study the way in which the extra haploid set of chromosomes exerts
      its effect on the phenotype. The antenatal diagnosis of late triploidy is
      discussed. The finding that 25 per cent of late triploids have spina bifida is
      further evidence that meningomyelocele has a genetic component and strongly
      suggests that this results from chromosomal imbalance or a regulatory gene
      disturbance.

PMID- 1034016
TI  - The de Lange syndrome in one of twins.
AB  - A pair of female monozygotic twins, one of them affected by the de Lange syndrome
      is described for the first time. Monozygosity was established by most of the
      accepted standards in use at the present time. Speculation is offered as to
      whether the discordance in the manifestation of the syndrome provides any clues
      for understanding its controversial pathogenesis. In this regard two genetic
      mechanisms are discussed. One is the hypothesis of a chromosomal or mitotic
      instability. The other possibility would be a postzygotic new mutation of a gene
      or large effect.

PMID- 1034017
TI  - Trimethylhydrazine hydrochloride as a tumor inducer in Swiss mice.
AB  - A 0.05% solution of trimethylhydrazine hydrochloride (TMH) administered for a
      lifetime in drinking water to outbred Swiss albino mice, beginning at 6 weeks of
      age, induced tumors of blood vessels, lungs, and kidneys. The tumor incidences in
      these tissues in untreated controls were 5,22 and 0%, whereas in the treated
      groups the corresponding tumor incidences increased to 85, 44, and 6%,
      respectively. Histopathologically, tumors were classified as angiosarcomas of
      blood vessels and adenomas of the lungs and kidneys. The study thus demonstrated
      the tumorigenicity of TMH. Contrary to expectation, the chemical structure
      modification apparently failed to alter qualitatively the tumorigenic response.

PMID- 1034018
TI  - Age incidence and site distribution of mammary dysplasias in young beagle
      bitches.
AB  - The age incidence and site distribution of 2,142 mammary dysplasias were
      documented for 39 beagle bitches 6 months to 4 years of age. Lesion onset was at
      2-3 years of age, at which time more than 50% of the females had dysplasias.
      Dysplasias appeared before palpable tumors. Posterior mammae developed more
      lesions than did anterior mammae. Thus the gradient for early onset of lesions
      coincided with the gradient for tumor frequency reported previously; a
      preneoplastic potential is suggested for (some) dysplasias. Problems of defining
      normal tissue are discussed.

PMID- 1034019
TI  - Hepatic angiosarcomas in dogs: an excessive frequency as compared with man.
AB  - A series of 18 angiosarcomas of the liver in dogs reported by veterinary schools
      in the United States and Canada suggested that certain breeds may have an excess
      of the tumor and that there is no marked predilection by sex. Histologic
      characteristics of hepatic angiosarcomas were similar in man and dog, but the
      relative frequency in dogs was about 25-100 times that of man.

PMID- 1034020
TI  - Mutant lines of guinea pig L2C leukemia. II. Comparative cytogenetic studies and
      banding analyses of normal and leukemic karyotypes.
AB  - Chromosomes of normal guinea pig (strain 2) cells and of cell lines dervied from
      a spontaneously arising leukemia were analyzed in detail. All cell lines studied,
      LG-L2C, GH-L2-C, BZ-LC, and EN-L2C, contained one M1 marker and two X
      chromosomes, in addition to other chromosome abnormalities specific for each cell
      line. The presence of the M1 marker and the two X chromosomes confirmed that all
      of these leukemic cell lines are derived from one ancestral line. Comparison of
      the chromosome markers and immunologic characteristics of these lines revealed
      that possibly the gene involved in the determination of C3 receptor sites is
      located on the terminal portion of the long arm of chromosome No. 2, but no other
      correlations could be made.

PMID- 1034021
TI  - Tumorigenicity of tetramethylhydrazine hydrochloride in Swiss mice.
AB  - Tetramethylhydrazine hydrochloride (TEMH) was administered in drinking water as a
      0.125% solution to randomly bred Swiss mice for life beginning at 6 weeks of age.
      As a result of treatment, the incidence of blood vessel tumors rose from 5 to 96%
      in females and from 6 to 88% in males, while that of lung tumors increased from
      21 to 36% in females and from 23 to 28% in males, as compared with untreated
      controls. The increased incidence of blood vessel tumors, but not of lung
      neoplasms, was statistically significant. Histopathologically, the tumors
      exhibited the characteristics of angiomas and angiosarcomas of blood vessels and
      adenomas of the lung. The investigation proved for the first time the
      tumorigenicity of TEMH. The possible role of increased methyl substitution on
      hydrazine in tumorigenesis was also discussed, as well as hydrazine derivatives
      as a tumor-producing class.

PMID- 1034022
TI  - The psychiatric assessment of candidates for cosmetic surgery.

PMID- 1034023
TI  - The accessory fibers of the sperm tail. High-sulfur and low-sulfur components in
      mammals and cephalopods.

PMID- 1034024
TI  - [Current therapeutic orientations for malignant teratomas of the testis with a
      choriocarcinomatous element. 14 cases (author's transl)].
AB  - In teratomas with a choriocarcinomatous element, the association with surgery of
      sequential chemotherapy lasting at least two years would appear to represent an
      improvement. Definitive conclusions may only be drawn from the study of large
      series.

PMID- 1034025
TI  - [Reconstruction of the female urethra using the roots of the clitoris. Eleven
      cases (author's transl)].
AB  - In 10 cases of obstetric and surgical necrosis of the urethra and in one of
      congenital aplasia, the canal was reconstructed using as an intermediate layer
      the roots of the clitoris, freed and applied. In the ten cases in which treatment
      has been completed, continence was restored in 8, either with one operation only
      (3 cases), or with the addition of various procedures for suspension of the
      bladder neck using autografts (5 cases).

PMID- 1034026
TI  - [The signification of renal sequential scintigraphy with determination of regions
      of interest for the therapeutical purpose in urology (author's transl)].
AB  - Sequential scintigraphy with regions-of-interest technique has a firm position in
      the diagnosis of localized lesions of renal parenchyma. The method is of little
      annoyance to the patient and is often decisive for the further diagnostic and
      therapeutical proceedings. The mathematical evaluation process takes little time,
      an advantage in emergency cases. Main indications are pathological duplex
      kidneys, staghorn calculi and anomalies of renal form and position. Radiation
      doses are low, a valuable factor in long-term controls, above all renal trauma
      and urotuberculosis.

PMID- 1034027
TI  - [Considerations relating to multiple primary carcinomas of the urinary tract
      (author's transl)].
AB  - The patient with more than one primary malignant neoplasm has ceased to be a
      pathologic curiosity and has instead become a practical problem. It is possible
      for a patient to have two simultaneous developping independant cancers, but is
      also possible for a second primary cancer to develop in a cancer prone individual
      after the initial malignant lesion has been removed by radical surgical
      procedures. The generally improved survival rate after treatment of cancer has
      permitted more patients to live long enough for a second or even a third primary
      lesion to develop and it probably also reflects the more thorough pathological
      studies in both surgical and autopsy cases. It may be hoped that factors of
      genetic predisposition, ethiology and pathogenesis that are obscure in the
      patient with single lesions may be brought out in patients with multiple cancers.
      We present the case of a 83 years old patient with three different primary
      malignancies. His first tumour was a clear cell carcinoma of the left kidney at
      the age of 71, followed by a transitional cell carcinoma gr. II/IV of the bladder
      seven years later, and followed by a third one two and a half years latter which
      was a distinct adeno carcinoma of the prostate.

PMID- 1034028
TI  - The influence of vesical distension on the urethral resistance to flow: a
      possible role for prostaglandins?
AB  - The possible role of prostaglandins in the mediation and/or modulation of the
      urethral response to vesical distension was investigated in female dogs. Three
      criteria for the possible involvement of these mediators have been investigated.
      Indomethacin could block the reduction of urethral resistance observed during
      vesical distension. Intra-arterial infusion of exogenous prostaglandin E2
      resulted in a dose-dependent reduction in the urethral resistance to flow.
      Moreover, a significant release of prostaglandin E2 in the venous blood during
      the course of vesical distension could be demonstrated. The functional
      significance, mechanisms of release and mode of action of these highly active
      lipids are discussed.

PMID- 1034029
TI  - Colpocystourethropexy: the way we do it.
AB  - In pure stress urinary incontinence the sphincteric mechanism is intact.
      Restoration of normal position and support to the vesicourethral segment usually
      re-establish normal sphincteric function. A suprapublic approach is used to gain
      adequate mobilization of the anteriorr vaginal wall and vesicourethral segment.
      Full thickness sutures applied in the anterior vaginal wall as far lateral from
      the urethra as possible are then tied to Cooper's ligament. Forward and upward
      lifting of the vesicourethral segment is achieved but the urethra is free in a
      wide retropubic space. Normal position with limited mobility of the sphincteric
      segment is attained, yet compression or obstruction of the urethra and surgical
      trauma to the delicate sphincteric musculature are avoided. Adsorbable sutures
      are used. Permanent fixation is to be achieved by the postoperative fibrosis made
      possible after all retropubic fat has been cleared away. This technique has been
      uniformly successful in virginal cases and in the great majority of the least
      favorable cases, after repeated failures. Adequate mobilization proper placement
      of sutures and prevention of compression and surgical damage are the keys to
      longlasting successful repair.

PMID- 1034030
TI  - Vesicoureteral reflux in identical twins.

PMID- 1034031
TI  - Mediastinal choriocarcinoma in a chromatin-positive boy.
AB  - A case of primary mediastinal choriocarcinoma in a chromatin-positive boy is
      reported. The incidence of neoplasms in patients with so-called Klinefelter's
      syndrome is discussed as well as embryogenesis and diagnostic evaluation in
      patients presenting with this tumor.

PMID- 1034032
TI  - [Heterogenous patterns of pleiotropy in PTS-mutants of Vibrio parahaemolyticus].

PMID- 1034033
TI  - [Sugar composition of crude lipopolysaccharides isolated from Yersinia
      enterocolitica 0-3, 0-5B and 0-9].

PMID- 1034034
TI  - [Studies of urinary 4-amino-5-imidazolecarboxamide (AIC) in human leukemias and
      other hematologic disorders (author's transl)].

PMID- 1034035
TI  - [A case of primary cold agglutinin disease with good response to melphalan
      (author's transl)].

PMID- 1034036
TI  - [Megaloblastic anemia due to folic acid deficiency observed in a pregnant women
      with hereditary spherocytosis (author's transl)].

PMID- 1034037
TI  - [Etiology and morphopathological characteristics of endocrinel neoplasms, with
      special reference to hyperplasia and diagnosis of malignancy].

PMID- 1034038
TI  - [Functional diagnosis of endocrine gland neoplasms].

PMID- 1034039
TI  - [Neoplasms of the zona glomerulosa of the adrenal cortex].

PMID- 1034040
TI  - [Neoplasms of the zona fasciculata of the adrenal cortex].

PMID- 1034041
TI  - [Congenital heart defects].

PMID- 1034042
TI  - [Colonic tuberculosis].

PMID- 1034043
TI  - Theoretical and therapeutic potential of indoleamine precursors (2).

PMID- 1034044
TI  - [Artificial pancreas--an automatic apparatus for continuous determination of
      blood sugar].

PMID- 1034045
TI  - [Agranulocytosis possible due to ajmalin--a case study].

PMID- 1034046
TI  - [Clubbed fingers in upper-gastrointestinal-transverse colon fistula syndrome-
      study of 2 cases].

PMID- 1034047
TI  - [Statistics on bladder neoplasms].

PMID- 1034048
TI  - [Epidemiological survey on bladder neoplasms in Nagoya City].

PMID- 1034049
TI  - [Left atrial radiography and p loop].

PMID- 1034050
TI  - [Hypertensice heart diseases and painless ischemic heart diseases-
      vectorcardiography and prognosis].

PMID- 1034051
TI  - [The bacterial isolates and their susceptibility to antimicrobial agents obtained
      from clinical speciments in Tokai-Hokuriku Area (author's transl)].

PMID- 1034052
TI  - [The rapid measurement for platelet volume (author's transl)].

PMID- 1034053
TI  - [Purification of plasminogen-free fibrinoge "practical method in clinical
      laboratory" (author's transl)].

PMID- 1034054
TI  - [Classification of platelet aggregation induced by two concentrations of ADP and
      its clinical significance in diabetics (author's transl)].

PMID- 1034055
TI  - [Effects of fixatives on preservation of the cell with the special reference to
      nuclear DNA and morphology (author's transl)].

PMID- 1034056
TI  - [Determination of serum cholinesterase activity using fast analyzer "RotoChem II"
      (author's transl)].

PMID- 1034057
TI  - [Reduction of patient exposure with X-ray TV by means of an automatic diaphragm
      (Servo-diaphragm) of X-ray tube; evaluation based on measurement of the area
      exposure integral].

PMID- 1034058
TI  - [Case of granuloma of the greater omentum].

PMID- 1034059
TI  - [Splenic scintigraphy (3). Splenic diseases].

PMID- 1034061
TI  - [Roentgenologic anatomy of hilar markings].

PMID- 1034060
TI  - [Problems concerning fractionated radiotherapy (2). Time-dosage distribution in
      relation to the repair of potentially lethal damage and repopuration of cancer
      cells].

PMID- 1034062
TI  - [Current methods of diagnosis of early cancer of the pulmonary hilum (1). Mode of
      disease progression and radiography of the early cancer of the hilum].

PMID- 1034063
TI  - [Current methods of diagnosis of early cancer of the pulmonary hilum (2)].

PMID- 1034064
TI  - [Plain radiographic and tomographic analysis of early cancer of the pulmonary
      hilum (1)].

PMID- 1034065
TI  - [Differential diagnosis of lung cancer and cancer with hilar metastasis: with
      special reference to diagnosis of subepithelial endobronchial metastasis
      simulating early hilar cancer in radiographic presentation].

PMID- 1034066
TI  - [Present status of surgically cured cancer of the pulmonary hilum].

PMID- 1034067
TI  - [Modes of development of the early stage of epidermoid carcinoma of the pulmonary
      hilum].

PMID- 1034068
TI  - [Case of cancer of the gastric cardia associated with para-esophageal hiatal
      hernia].

PMID- 1034070
TI  - [Computer tomography and its future role in nuclear medicine].

PMID- 1034069
TI  - [Computer tomography].

PMID- 1034071
TI  - [Rotation radiography and computer tomography].

PMID- 1034072
TI  - [Significance of image enhancement with contrast media in cranial computed
      tomography].

PMID- 1034073
TI  - [Experiences with computed tomography in a children's hospital].

PMID- 1034074
TI  - [Computerized tomography--its diagnostic values in pediatric neurosurgery].

PMID- 1034075
TI  - [Radiation dosage of computerized tomography--with special reference to CT-H
      250].

PMID- 1034076
TI  - [Preoperative radiotherapy and radical radiotherapy of esophageal cancer].

PMID- 1034077
TI  - [Clinical significance of liver scintigraphy with changes in body position].

PMID- 1034078
TI  - [Primary amyloidosis of the small intestine--a case study].

PMID- 1034079
TI  - [Nuclear medicine seen in postal stamps (6)].

PMID- 1034080
TI  - [Pelvic abscess].

PMID- 1034081
TI  - [Spleenic scintigraphy. 4. 99mTc-erythrocytes].

PMID- 1034082
TI  - [Divided dosage in radiotherapy. 3. Clinical application].

PMID- 1034083
TI  - [Selective bronchial arteriography in lung neoplasms].

PMID- 1034084
TI  - [Studies of thyroid tissue following treatment of hyperthyroidism with I131. 2.
      Dosages and frequencies of I131 administration with the dosages less than 10
      mci].

PMID- 1034085
TI  - [Radiographic diagnosis of small pancreatic neoplasms].

PMID- 1034086
TI  - [11 cases of Behcet's syndrome, with special reference to the diagnosis of
      intestinal lesions].

PMID- 1034087
TI  - [Extensive esophagitis in Behcet's syndrome].

PMID- 1034088
TI  - [4 cases of intestinal Behcet's syndrome, with special reference to its
      radiographic observation].

PMID- 1034089
TI  - [Tuberculosis of the mesenteric lymph node with an interesting radiographic
      presentation].

PMID- 1034090
TI  - [3 cases of fenestration of the vertebral artery].

PMID- 1034091
TI  - [Defects of the suprapatellar bursa visualized in the radiography of the knee
      joint].

PMID- 1034092
TI  - [Double contrast study of the colon by a remote control].

PMID- 1034093
TI  - [Nuclear medicine seen in postal stamps].

PMID- 1034094
TI  - [Colonic diverticulitis and sigmoid-vesical fistula].

PMID- 1034095
TI  - [Bone marrow scintigraphy].

PMID- 1034097
TI  - [Studies of the relationship between skin surface lipids and transepidermal water
      loss (author's transl)].

PMID- 1034096
TI  - [Radiotherapy of ovarian neoplasms].

PMID- 1034098
TI  - [Systemic effects of topical corticosteroid therapy (author's transl)].

PMID- 1034099
TI  - [Genetic control of contact hypersensitivity to potassium dichromate in guinea
      pigs (author's transl].

PMID- 1034100
TI  - [An ultrastructural observation of intracytoplasmic gap junctions in Darier's
      disease (author's transl)].

PMID- 1034101
TI  - [Clinical significance of serum mitochondrial GOT in liver diseases].

PMID- 1034102
TI  - [Ribonuclease activity in the duodenal juice, serum and urine during pancreozymin
      secretin test. 1. Determination of ribonuclease activity].

PMID- 1034103
TI  - [Morphology and function of the pancreas in chronic pancreatitis--statistical
      studies using retrograde cholangiopancreatography and pancreozymin-secretin
      test].

PMID- 1034104
TI  - [Scanning electron microscopic observation of the regenerated epithelium in
      various stages of healing in gastric ulcer].

PMID- 1034105
TI  - [Management of hapatic coma with closed circuit cytoglomeration and plasma
      exchange (3C-PE)].

PMID- 1034106
TI  - [Clinical statistics on drug-induced liver damage. (2) Cases observed in the past
      50 years in Japan].

PMID- 1034107
TI  - [Clinical evaluation of choledochofiberscope].

PMID- 1034108
TI  - [Efficacy and safety of chenodeoxycholic acid therapy for dissolution of
      gallstones].

PMID- 1034109
TI  - [Experimental gastrointestinal neoplasms].

PMID- 1034110
TI  - [Abnormal fibrinolysis and serum lipid levels in the liver cirrhosis and
      prognosis].

PMID- 1034111
TI  - [Geographical pathology of the aging process of the kidney, with special
      reference to Japanese in Hawaii].

PMID- 1034112
TI  - [Examination of adult population in Fukuoka City. 1. Age-related
      Electrocardiographic changes and test results of those who died later].

PMID- 1034113
TI  - [Changes of blood pressure and body temperature during the acute stage of stroke
      and its implication on prognosis].

PMID- 1034114
TI  - [Changes of hematocrit and electrolyte and urea nitrogen concentrations during
      the acute stage of stroke].

PMID- 1034115
TI  - [Effects of steroids on cerebral infarct and hemorrhage in the aged--studies on
      improvement of consciousness level and mortality rate].

PMID- 1034116
TI  - [Cholelithiasis in the aged--autopsy cases].

PMID- 1034117
TI  - [Serum digitoxin levels in the aged].

PMID- 1034118
TI  - [Risk factors of cerebral arteriosclerosis--studies based on cerebral
      angiography].

PMID- 1034119
TI  - [Reversible myocardial infarction in the aged following blood transfusion].

PMID- 1034120
TI  - [Senile and vascular dementias--their temporal profiles].

PMID- 1034121
TI  - [Clinical studies of cardiac functions in ischemic heart disease].

PMID- 1034122
TI  - Trisomy 5 in two abortuses.

PMID- 1034123
TI  - Tricho-rhino-phalangeal syndrome: report on three unrelated families.

PMID- 1034124
TI  - A rare variant type of 6-phosphogluconate dehydrogenase found in Japanese.

PMID- 1034125
TI  - Further examples of Gc variant (Gc J) found in a Japanese family.

PMID- 1034126
TI  - [A clinical genetic study on congenital hypertrophic pyloric stenosis (author's
      transl)].

PMID- 1034127
TI  - [On the zygosity diagnosis of twins by finger prints: usefulness of pattern
      intensity (author's transl)].

PMID- 1034128
TI  - [Immunohistological studies and isolation of antigen in acute glomerulonephritis
      and anaphylactic purpura nephritis].

PMID- 1034129
TI  - [Malignant nephrosclerosis in a 15-year-old girl].

PMID- 1034130
TI  - [Experimental studies on the effects of acetylcholine and renal cholinergic
      nerves on renal circulation and kidney tubular function].

PMID- 1034131
TI  - [Serum IgE levels in nephrotic syndrome. Part 2].

PMID- 1034132
TI  - [Process of complement activation in systemic lupus erythematosus and acute
      nephritis].

PMID- 1034133
TI  - [Case of medullary cystic disease and a review of the literature].

PMID- 1034134
TI  - [Unilateral renal hypoplasia with hypertension - similarity to "Ask-Upmark"
      kidney].

PMID- 1034135
TI  - [Dietic therapy in renal diseases].

PMID- 1034136
TI  - Effects of rubidium on behavioral responses to methamphetamine and tetrabenazine.
AB  - Different groups of mice were injected subcutaneously every other day with
      rubidium chloride at three doses (0.41(50), 1.23(150) and 3.69(450) meq/kg
      (mg/kg)) or with saline as a control for a period of 2-3 weeks. Rubidium
      administered acutely did not affect spontaneous locomotor activities, while it
      tended to increase the activities when administered repeatedly though the
      increase was not statistically significant. The methamphetamine-induced
      hyperlocomotor activities were potentiated in the rubidium groups as compared
      with those in the saline group, this effect of ribidium being increased with
      prolongation of repeated administrations. Monotonic decreases in ambulation after
      tetrabenazine were not significantly affected in the rubidium-treated animals
      though the decreases were sometimes preceded by slight increases and recovery
      from the decrement tended to be more rapid. After tetrabenazine in the rubidium
      treated groups, incidences of catalepsy were increased and jumping behavior and
      Straub tail responses occurred in a few cases. The results suggest that rubidium
      potentiates the excitatory action of methamphetamine on spontaneous locomotor
      activities, as contrasted with inhibitory influence of lithium.

PMID- 1034138
TI  - [Systems theory applied to the lung mechanics].

PMID- 1034137
TI  - [Pulmonary diseases due to circulatory disturbances (with special reference to
      adult respiratory distress syndrome and hepatogenic cyanosis)].

PMID- 1034139
TI  - [Effects of asbestos and beryllium on the pulmonary macrophages].

PMID- 1034140
TI  - [Surgical management of total anomalous pulmonary venous drainage].

PMID- 1034141
TI  - [Surgical correction of tetralogy of Fallot in adults].

PMID- 1034142
TI  - [Problems of total correction of tetralogy of Fallot in adolescents and adults].

PMID- 1034143
TI  - [Total correction of tetralogy of Fallot in children under 2].

PMID- 1034144
TI  - [Correction of tetralogy of Fallot by reconstructing the right pulmonary artery
      by transection of the ascending aorta].

PMID- 1034145
TI  - [Total correction of double outlet right ventricle with creation of an internal
      conduit].

PMID- 1034146
TI  - [Postoperative complications and management in open heart surgery].

PMID- 1034147
TI  - [Preisthmic type aortic coarctation and its surgical management].

PMID- 1034148
TI  - [Successful surgical management of stridor and dysphagia caused by aberrant right
      subclavian artery, and etiological studies of literature].

PMID- 1034149
TI  - [A histopathological criterion for malignancy of bladder carcinoma from
      viewpoints of growth and spread (author's transl)].

PMID- 1034150
TI  - [Scanning electron microscopic study on the developmental process of renal
      oxalate stone (author's transl)].

PMID- 1034151
TI  - [Electron microscopic study on the chronological changes of the experimental
      bladder carcinogenesis (author's transl)].

PMID- 1034152
TI  - [Lower urinary tract obstruction and subclinical neurogenic bladder in childhood:
      I. Analytical studies of micturating cysto-urethrographic patterns based on
      urodynamic investigations, especially on urethral pressure (author's transl)].

PMID- 1034153
TI  - [Studies on prostatectomy and anesthetic methods (author's transl)].

PMID- 1034154
TI  - A transport mechanism of methyl mercury to egg albumen in layer Japanese quail.

PMID- 1034155
TI  - Comparison of pathogenicity in chickens of Mycoplasma synoviae with special
      reference of a Japanese isolate.

PMID- 1034156
TI  - Histopathology of purulent arthritis of chickens.

PMID- 1034157
TI  - [Studies on bacterial flora in the alimentary canal of dogs. II. Development of
      the fecal bacterial flora in puppies].

PMID- 1034158
TI  - [Pathological studies on pulmonary circulatory disturbance in canine
      dirofilariasis: postmortem pulmonary angiography].

PMID- 1034159
TI  - Serological investigation on Salmonella carrier-dogs.

PMID- 1034160
TI  - Further investigation on the dye and hemagglutination tests for the latent swine
      toxoplasmosis.

PMID- 1034161
TI  - [Esophageal complications in tracheotomied premature infants].

PMID- 1034162
TI  - [Recovery from severe combined trauma with avulsion of the bladder and uterus
      from the urethra and vagina in an 8-year-old girl].

PMID- 1034163
TI  - [Experimental laser iridectomy. I. Clinical studies].

PMID- 1034164
TI  - [Partial thromboplastin time (PTT) in the pediatric age group. Normal values and
      changes under different storage conditions (author's transl)].
AB  - Normal values for PTT were obtained from 60 infants and children- age 3 days to
      14 years- who had unremarkable preoperative coagulation tests and had tolerated
      surgical procedures without bleeding complications. The 27 infants, who were less
      than 0.5 years old, had significantly longer PTT-times (mean value 37.65 sec.,
      extreme values 29.6-47.4 sec) than the older children (mean value: 32.72 sec.,
      extreme values: 24.9-40.5 sec). These results, which were obtained with PTT
      reagent ROCHE, are considerably shorter than comparable values in the literature.
      There were no differences in the values from boys or girls. No positive
      correlation between PTT and bleeding time were found. There were no significant
      changes of PTT when the whole blood had been stored at room temperature (22-25
      degrees C) for 6 to 10 hours before it was tested.

PMID- 1034165
TI  - [Retention of platelets in newborns (author's transl)].
AB  - In healthy, 24-72 hour-old newborns, platelet retention is significantly elevated
      compared to adults. A relationship could not be established between the retention
      and the erythrocyte count, bilirubin in the serum or the content of energy-rich
      phosphates in the erythrocytes. The above results indicate that the platelet
      function in newborns is elevated and/or comparable with the adult norm. The basic
      cause of the frequent symptoms of hemorrhage during the newborn period cannot be
      traced back to disturbed thrombocyte function.

PMID- 1034166
TI  - Neonatal respirator allowing simultaneous ventilation and suction.
AB  - A new type of respirator for newborns allowing tracheal suction and ventilation
      simultaneously is presented. Additional characteristics are: a partly disposable
      air supply system, no apparatus deadspace and with one exception no moving parts.
      The performance of the respirator under varied conditions of lung mechanics was
      tested using a pneumatic lung thorax analogue. The procedure of tracheal suction
      was simulated and the effect on tidal volume and alveolar pressure investigated.
      Triggervolume and response time were also determined. Analysis shows that the
      respirator has qualities of flow- and pressure preset ventilators. Tracheal
      suction during ventilation does not impair the delivery of tidal volume. In
      mechanical ventilation with PEEP the alveolar pressure remains positive
      throughout the respiratory cycle despite suction.

PMID- 1034167
TI  - [Corticosteroid therapy in atopic diseases of children? (author's transl)].
AB  - Of 416 children suffering from different atopic diseases who were admitted as in
      patients in a German aero-biological childrens clinic, 69.2% had previously
      received corticosteroid therapy. According to dermatological findings, 81.9% of
      these patients developed undesirable side effects. Of the children whose atopic
      dermatitis was treated prolonged with topical corticosteroids, also irreversible
      body changes developed through the transcutaneous absorptive processes, which
      were more evident and appeared more often in girls than in boys.

PMID- 1034168
TI  - [Cytostatic therapy in a patient with histologically verified, but not
      irradiatied, brain stem glioma (author's transl)].
AB  - A boy, aged 8 1/2 years, was operated becuase of a brainstem tumor (polymorph
      mixed glioma) more than 4 years ago. Because of its dimension and location in the
      medulla oblongata the tumor was resected only partially. Radiotherapy was refused
      at that time. A combined cytostatic therapy proved to be successful. The marked
      neurological symptoms diminished considerably during treatment. The patient (with
      minor neurological symptoms) has been living a normal and active life for the
      last 4 years.

PMID- 1034169
TI  - [Intracranial hemorrhage in idiopathic thrombocytopenic purpura (ITP) (author's
      transl)].
AB  - Intracranial hemorrhage is a rare, lifethreatening complication of immun-allergic
      thrombocytopenia (ITP). A 4 8 1/2 year old boy, who developed intracranial
      hemorrhage while receiving long term steroid treatment for ITP, was successfully
      managed by emergency splenectomy. Possible treatment for this condition is
      discussed.

PMID- 1034170
TI  - [Heroin withdrawal syndrome in newborns (author's transl].
AB  - A case of a severe heroin withdrawal syndrom in a newborn infant is reported.
      Diagnostic and therapeutic aspects of the disease are reviewed.

PMID- 1034171
TI  - [Risks and results of banding surgery (author's transl)].
AB  - A Muller-Dammann banding operation was performed in 64 infants and small children
      within 5 years. The diagnosis and the surgical risk (between 5.9% and 65%
      depending on the degree of intracardial malformation) were presented.
      Complications and cause of death were described and compared with data presented
      in the literature. Twenty-three patients were given a follow-up examination with
      special cardiac diagnostic methods. The hemodynamic results were compared with
      those from 9 children who were operated on late. As other authors, were also
      found a pronounced reduction in pulmonary flow in those children operated on
      early and not in those operated on late.

PMID- 1034172
TI  - [Casuistic contribltion to acquired knee extension contracture in childhood
      (author's transl)].
AB  - On the basis of two observations, the clinical symptoms for acquired knee
      extension contracture in childhood was presented. A progressive fibrosis of the
      vastus intermedius of the musculus quadriceps femoris develops as a result of
      multiple injections into the ventral thigh musculature. This method of
      application should, therefore, be avoided and an intragluteal or intravenous
      method used.

PMID- 1034173
TI  - [Effectiveness of thyrocalcitonin in the treatment of steroid-induced
      osteoporosis].

PMID- 1034174
TI  - Investigating ethnic prejudice among boys in residential treatment.

PMID- 1034175
TI  - Cytoskeletal elements of chick embryo fibroblasts revealed by detergent
      extraction.
AB  - Treatment of chick embryo fibroblasts with 0.5% Triton X-100 extracts most of the
      cell protein, leaving an organized part of the cell structure attached to the
      tissue culture dish. This "Triton cytoskeleton" consists largely of intermediate
      sized filaments and bundles of microfilaments. SDS polyacrylamide gel
      electrophoresis reveals that this cytoskeleton is made up of three main proteins.
      One protein component is 42,000 daltons and co-migrates with muscle actin. The
      other two components are 52,000 and 230,000 daltons and remain quantitatively
      associated with the cytoskeleton during the detergent extraction. The possible
      identity of these three protein components and their organization into a
      supramolecular structure is discussed.

PMID- 1034176
TI  - Morphological and biochemical abnormalities in hearts of cardiac mutant
      salamanders (Ambystoma mexicanum).
AB  - The effect of homozygosity for recessive gene c in Ambystoma mexicanum is the
      absence of a heartbeat even though initially heart development appears normal.
      Mutant embryos (c/c) are first distinguishable from their normal siblings
      (+/+;+/c) at stage 34 (7 days after fertilization) when the normals develop
      contracting hearts. The mutant hearts at this stage, upon gross examination,
      appear structurally normal but fail to beat. Nevertheless, the mutants survive
      through stage 41, which is about 20 days beyond the heartbeat stage, and they
      exhibit normal swimming movements, indicating that gene c does not affect
      skeletal muscle. Electron microscopic studies of normal hearts show some
      myofibrils to be present at stage 34; by stage 41, the normal myocardial cells
      have become highly differentiated muscle cells. Although some mutant heart cells
      contain a few thin 60 A and thick 150 A filaments, organized myofibrils are
      absent. Instead, amorphous proteinaceous collections are prominent. Heavy
      meromyosin (HMM) binding experiments were performed on mutant hearts to determine
      whether the myocardial cells contain actin. Mutant myocardial cells that are
      glycerinated but not treated with HMM contain intact amorphous bodies. After
      incubation in HMM, the amorphous collections are no longer present and large
      numbers of decorated actin filaments appear. The.results suggest that the
      amorphous proteinaceous collections contain actin in a nonfilamentous form, and
      the addition of HMM induces this actin to polymerize into filaments. SDS
      polyacrylamide gel electrophoresis of mutant heart tissue supports this
      conclusion by showing a prominent 43,000 dalton band suggestive of actin. The
      electrophoresis experiments also demonstrate a significant reduction of myosin
      heavy chain (200,000 daltons) in mutant hearts when compared to normal, and this
      latter observation is confirmed by radioimmunoassay experiments. Muscle
      tropomyosin (34,000 daltons), prominent in normal hearts, is virtually
      nonexistent in mutants. Thus, it appears that this single gene mutation affects
      the accumulation and organization of several different muscle proteins, including
      actin, myosin, and tropomyosin.

PMID- 1034177
TI  - Selective breeding of rats for differences in reactivity to alcohol. An approach
      to an animal model of alcoholism. I. General procedures.
AB  - Strains of rats are being developed which have distinct responses in spontaneous
      locomotor activity to a subhypnotic dose of alcohol. The purpose is to produce
      one strain in which the injection of a standard dose of alcohol will result in
      objectively measurable intoxication and a second in which an identical dose will
      result in virtually no effect.

PMID- 1034178
TI  - Effect of housing density on alcohol consumption by rats.
AB  - Rats housed six to a cage drank significantly more of a 10% alcohol solution than
      those housed three per cage or individually. Open-field behavior was negatively
      correlated with alcohol intake.

PMID- 1034179
TI  - Alcohol withdrawal effects on brain serotonin in mice behaviorally attracted to
      alcohol.
AB  - Serotonin concentration in whole brain tissue of CF1 mice behaviorally attracted
      to a 3% alcohol solution was significantly depressed 48 hours after access to the
      solution was denied. Norepinephrine concentration was not affected.

PMID- 1034180
TI  - Studies on the mechanisms of 6-hydroxydopamine cytotoxicity.
AB  - The uptake-accumulation and binding of radioactivity in mouse heart after
      administration of the catecholamine neurotoxin [3H]6-hydroxydopamine (6-OH-DA, 1
      or 3 mg/kg, i.v.) has been investigated. It was confirmed that a substantial
      portion (8--20%) of the radioactivity taken up and retained by the heart could
      not be extracted with perchloric acid, in all probability representing covalently
      bound oxidation products of 6-OH-DA to tissue proteins. Pharmacological analysis
      showed that a large part of this fraction was associated with the adrenergic
      nerves. The time-course of the perchloric acid resistant binding to the
      adrenergic nerves was found to parallel that of the neurotoxic action of 6
      hydroxydopamine as evaluated by monitoring the change in [3H]noradrenaline
      uptake. Calculation of the intranelronal 6-hydroxydopamine concentration
      (average) needed to induce degeneration showed it to be in the order of 50 mM.
      The binding ratio for tritium deriving from [3H]6-OH-DA between the intraneuronal
      and extraneuronal compartments was found to be 10,000 to 30,000, pointing to a
      very high neuronal specificity for 6-hydroxydopamine. The 'covalent' binding of
      oxidation products of [3H]6-OH-DA was considerably reduced after desipramine or 1
      phenyl-3(2-thiazolyl)-2-thiourea administration, treatments both known to protect
      the adrenergic nerves from undergoing degeneration. Conversely it was found that
      the binding increased during conditions known to potentiate the neurotoxic action
      of 6-hydroxydopamine, e.g., after monoamine oxidase inhibition with nialamide.
      Subcellular fractionation studies indicated that the predominant site of
      interaction between 6-hydroxydopamine oxidation products and neuronal proteins is
      the cytoplasm and the axonal membrane. Analysis of the effect in vivo
      administration of 6-hydroxydopamine on the field-stimulated induced release of
      [3H]noradrenaline previously taken up in the adrenergic nerves showed a 6
      hydroxydopamine indiced reduction in [3H]noradrenaline release which was
      approximately proportional to the reduction in the number of nerve terminals.
      These findings further support the view that 6-hydroxydopamine acts largely in an
      "all-or-none' fashion with respect to the neurodegenerative action.
      Administration of [3H]dopamine also resulted in a fraction which was not
      extractable with perchloric acid, although this fraction was very small compared
      to that found after an equal dose of [3H]6-hydroxydopamine. These data may
      indicate that oxidation products of dopamine can interact with tissue proteins.
      From the present results it can be concluded that there is a close relationship
      between 'covalent' binding of 6-hydroxydopamine oxidation products to neuronal
      elements and the cytotoxic action of 6-hydroxydopamine, indicating that this
      binding may play an important role in the neurodegenerative action of 6
      hydroxydopamine on catecholamine neurons.

PMID- 1034181
TI  - [Effect of phosporo-organic pesticides on in vitro function of human fibroblast
      cells. III. Action of folithione and intrathione].

PMID- 1034182
TI  - [Experiences with technical aids for insufficient voice and nasal speech].

PMID- 1034183
TI  - [Psychotherapy, pharmacotherapy and the future].

PMID- 1034184
TI  - [Correlation of anamnestic, neurological and EEG findings in minimal cerebral
      dysfunction (author's transl)].

PMID- 1034185
TI  - The interaction between spontaneous convulsions and tolerance to hexobarbital in
      the abstinence after chronic barbital treatments in the rat.

PMID- 1034186
TI  - Neonatal corticoid administration: retardation of adrenal rhythmicity and
      desynchronization of puberty.

PMID- 1034187
TI  - [Modification of the active principle of Solanum malacoxylon through the
      incubation with ruminal fluid].

PMID- 1034188
TI  - Cultivation of mammalian cell lines in serum-free chemically defined medium.

PMID- 1034189
TI  - Improved synthetic media suitable for tissue cllture of various mammalian cells.

PMID- 1034190
TI  - Long-term preservation of the Ehrlich ascites tumor.

PMID- 1034191
TI  - Isolation of drug-resistant clones of Ehrlich ascites tumor cells.

PMID- 1034192
TI  - Separation of clonogenic cells from stationary phase cultures and a murine
      fibrosarcoma by density-gradient centrifugation.

PMID- 1034193
TI  - [Development and differentiation of mycelium of Trichothecium roseum in submerged
      culture].
AB  - Ontogenesis of Trichothecium roseum during biosynthesis of trichothecin was
      studied during submerged cultivation on maize and synthetic media. Growth of the
      fungus is polycyclic; several generations of the submerged mycelium develop from
      the submerged conidia on the maize medium, and from the submerged conidia,
      chlamydospores and budding mycelium on the synthetic medium. Differentiation of
      the mycelium favours biosynthesis of the antibiotic. The nuclei in the cells of
      the submerged mycelium differ by their number, dimensions, and shape (round and
      elongated, polyploid). Several nuclei are found in the cells of the submerged
      mycelium more often during growth on the synthetic medium; this phenomenon is
      related to the reproductive cells -- submerged conidia and chlamydospores.

PMID- 1034194
TI  - [Cytological mechanisms involved in assimilation of n-alkanes by yeasts].
AB  - The paper describes cytological mechanism of adaptation of yeasts to assimilation
      of aliphatic hydrocarbons added to a growth medium as a sole source of carbon.
      The process was studied by light optical and electron microscopy, employing
      fluorescent labelling and electron microscopy contrasting. Two types of yeasts
      were found, which differed by the response of the cell walls to hydrocarbons:
      those that formed "channels" and those that did not form them. Cytological
      response to hydrocarbon assimilation was detected also in the mitochondria and
      canals of the endoplasmic reticulum. Components of the Golgi apparatus may also
      participate in this process, in particular, in formation of peroxisomes
      (microbodies). Close contacts of the yeast cells with the hydrocarbon being
      assimilated is important; assimilation may start in a close vicinity of the cell
      walls. The rate of flavin production by Candida tropicalis 303 IBFM increases
      during growth on solid paraffins, beginning with C20-paraffin.

PMID- 1034195
TI  - [Zeitrafer microfilming and electron microscopic study of the interaction of
      different cells in immunocompetent system].

PMID- 1034196
TI  - Diabetic retinopathy.

PMID- 1034197
TI  - [Anesthesia in small children and infants with and without heart disease].

PMID- 1034198
TI  - [Motivation of patient's escapes from psychiatric hospitals].

PMID- 1034199
TI  - Bone-resorbing activity of analogues of 25-hydroxycholecalciferol and 1,25
      dihydroxycholecalciferol: effects of side chain modification and
      stereoisomerization on responses of fetal rat bones in vitro.

PMID- 1034200
TI  - Oxygen-dependent reaction of 6-hydroxydopamine, 5,6-dihydroxytryptamine, and
      related compounds with proteins in vitro: a model for cytotoxicity.

PMID- 1034201
TI  - Induction and decay of aryl hydrocarbon hydroxylase activity in mouse 3T3 cells.

PMID- 1034202
TI  - '3H-testosterone distribution and binding in rat thymus cells in vivo'.
AB  - Autoradiography and biochemical investigations showed that [3H]-testosterone
      where injected intraperitoneally into male white rats was incorporated rapidly
      into thymus lymphocytes. Thymic cortex contained more silver grains than medulla,
      and larger lymphocytes were more labelled than medium or small lymphocytes.
      Cytosol fraction of thymus cells labelled in vivo with [3H]-testosterone,
      contained the largest quantity of labelled hormone. A 4S cytosol fraction binds
      [3H]-testosterone. This could be separated by Sephadex chromatography or by
      linear sucrose gradient centrifugation. Nuclear extract contained also a small
      quantity of the labelled hormone.

PMID- 1034203
TI  - Stabilization of double-stranded DNA molecule by non-histone peptidic effector
      from calf thymus.
AB  - A peptidic effector from calf thymus causes a strong stabilization of DNA double
      stranded molecule in vitro. The active factor was isolated from aqueous
      ultrafiltered thymus extracts and purified by means of chromatography on DEAE
      cellulose and then on Dowex 50 WX2. The purified thymic factor was characterized
      as a peptide of low molecular weight (less than 5000). The biological activity of
      the thymic factor cannot be attributed to a histone fragment. Melting data of the
      control DNA and of the DNA-active factor complex in various conditions of ionic
      strength and dielectric constant of the solution medium are recorded.

PMID- 1034204
TI  - Synthesis of delta crystallin from embryonic chick lens messenger
      ribonucleoprotein complex.
AB  - A single, major 21 S messenger ribonucleoprotein (mRNP complex) was isolated and
      purified by sucrose gradient centrifugation after EDTA treatment of high salt
      washed polysomes from 15 day embryonic chick lenses. A 17 S mRNA was released
      from the 21 S subunit of delta crystallin. Similar results were obtained with the
      17 S mRNA released from the 21 S mRNP complex.

PMID- 1034205
TI  - Characterization of poly(A)-protein complexes isolated from free and membrane
      bound polyribosomes of Ehrlich ascites tumor cells.
AB  - Proteins present in messenger ribonucleoprotein particles were labeled with [35S]
      methionine in Ehrlich ascites tumor cells in which synthesis of new ribosomes was
      inhibited. Poly(A)-protein complexes were isolated from free and membrane-bound
      polyribosomes by sucrose gradient centrifugation and affinity chromatography on
      oligo(dT)-cellulose. Both classes of Poly(A)-protein particles contain a poly(A)
      chain of about 70 adenyl residues and a protein with a molecular weight of 76000
      attached to it.

PMID- 1034206
TI  - A xeroderma pigmentosum patient having a high residual activity of unscheduled
      DNA synthesis after UV is assigned to complementation group A.

PMID- 1034207
TI  - [Antigenic characteristics of Emmonsia crescens Emmons et Jellison 1960].

PMID- 1034208
TI  - Cytoskeletal control of surface membrane mobility.
AB  - Cytochalasin B induced redistribution of actin microfilaments into a bulge of the
      cytoplasm, bringing cell-surface elements to the corresponding surface area. This
      process was reversible, inhibited by colchicine and enhanced by antibodies to
      cell-surface antigens.

PMID- 1034209
TI  - Growth regulation of cells grown in suspension culture.

PMID- 1034210
TI  - Cell surface design.

PMID- 1034211
TI  - Digynic triploidy after superovulation in mice.

PMID- 1034212
TI  - Mutagenesis and transformation of normal cells by chemical carcinogens.

PMID- 1034213
TI  - Structure of porcine pancreatic prephospholipase A2.

PMID- 1034214
TI  - A human chromosomal determinant for susceptibility to herpes simplex virus.

PMID- 1034215
TI  - Tidal rhythm in a seabird.

PMID- 1034216
TI  - Effect of plant cytokinins on microfilaments and tight junction permeability.

PMID- 1034217
TI  - Uniqueness of plasminogen activators.

PMID- 1034218
TI  - Temperature sensitive defect in human-hamster cell hybrid.

PMID- 1034219
TI  - Porcine pituitary peptides with opiate-like activity: partial purification and
      effects in the rat after intraventricular injection.
AB  - A peptide material with opiate-like activity in the guinea-pig ileum was
      extracted from porcine pituitaries using a hot glacial acetic acid extraction
      method and was partially purified by gel filtration. When injected
      intraventricularly in rats, these purified peptides induced strong analgesia,
      catelepsy, respiratory depression and other opiate-like effects, which lasted for
      several hours.

PMID- 1034220
TI  - Tolerance and dependence induced by morphine-like pituitary peptides in rats.
AB  - An extract from porcine pituitaries containing peptides with opiate-like activity
      (endorphins) was investigated for possible tolerance/dependence liability in
      rats. Repeated intraventricular administration of endorphins induced a degree of
      tolerance similar to that induced by normorphine. Rats made tolerant to morphine
      by repeated pellet implantation proved cross-tolerant to the pituitary extract as
      well as to synthetic methionine-enkephalin. Naloxone given to rats, repeatedly
      pretreated with endorphins, precipitated a withdrawal syndrome strongly
      resembling that induced in rats treated with normorphine. Withdrawal precipitated
      in morphine-dependent rats was suppressed by intraventricularly applied
      endorphins. The results suggest that identical sites and mechanisms are involved
      in the development of tolerance/dependence induced by opiates and pituitary
      endorphins.

PMID- 1034221
TI  - Inverse diurnal variation of blood plasma 11-hydroxycorticosteroids level in
      cancer patients.
AB  - The plasma level of 11-hydroxycorticosteroids was examined twice a day by means
      of MATTINGLY'S fluorometric method in patients with malignant and other chronic
      diseases and in control subjects. Higher values in the afternoon or the same as
      those in the morning were found in each case of malignant disease. This change of
      physiological diurnal rhythm was not observed in the vast majority of healthy
      subjects or in patients with non-cancerous diseases.

PMID- 1034222
TI  - [Noblesse oblige].

PMID- 1034223
TI  - [Ultrastructure of blood-brain barrier (author's transl)].

PMID- 1034224
TI  - [Reduction technique of zygomatic fracture (author's transl)].

PMID- 1034225
TI  - [Dejerine-Roussy syndrome (author's transl)].

PMID- 1034226
TI  - [Determination of blood polyamines in patients with brain tumor -with special
      reference to relationship between varieties of tumors and concentrations of blood
      spermidine and spermine (author's transl)].
AB  - Examination of blood polyamines in 38 patients with brain tumor and 17 normal
      volunteers was carried out by columnar chromatography--cellulose acetate membrane
      electrophoresis. The upper limits of the normal values; M.+2S.D. of the blood
      polyamine concentrations in 17 normal volunteers, were less than 2.1 mg/ml for
      spermidine, less than 1.6 mg/ml for spermine, and less than 2.2 mg/ml for
      spermidine plus spermine. The values of blood polyamines in 21 cases with glioma
      were significantly higher than those in normal subjects (p less than 0.01). And
      in 14 out of them, the concentrations of the blood polyamines were higher than
      the maximum normal value. In one case with reticulum cell sarcoma, the
      concentrations of the blood polyamines were remarkably increased. In 2 out of 4
      cases with metastatic brain tumor the concentration of the blood polyamines were
      higher than the upper limit of normal amount, and values of the blood polyamines
      in 4 cases with metastatic brain tumor were significantly higher than those in
      normal volunteers (p less than 0.05). In none of 2 cases with pituitary adenoma,
      3 cases with meningioma, 4 cases with neurinoma, one case with hemangioblastoma,
      and one case with pinealoma, the values of the blood polyamines were
      significantly higher than those in normal volunteers. The CSF samples obtained
      from 9 patients with brain tumor, consisted of 6 gliomas (glioblastoma multiforme
      2, anaplastic glioma 4), 1 teratoblastoma, 1 von Recklinghausen's disease
      (neurinoma and meningioma), and 1 craniopharyngioma, were analyzed for detection
      of polyamines, but no detectable amount was present in those cases.

PMID- 1034227
TI  - [Normal meatogram (author's transl)].
AB  - Meatograms obtained in 33 patients (41 examinations) in whom cerebello-pontine
      angle tumor was excluded clinically and operatively, were studied. Meatographies
      were performed with a small quantity of contrast medium, and restricted to the
      visualization of the structures in the auditory canal. Tomographies of antero
      posterior view were utilized in all the cases. Normal tomomeatograms were
      classified into 4 types. In the first type the internal auditory canal not
      opacified, in the second the contrast medium recognized as a single stream along
      the superior wall of the internal auditory canal, in the third another parallel
      line of contrast medium is recognized close to the middle of the internal
      auditory canal, and in the fourth the contrast medium fills the internal auditory
      canal with two transparent lines corresponding to the arrangement of the nerves.
      The nerve roots were recognized as peripheral recess in lateral tomograms of the
      internal auditory canal. These types of normal meatograms are related to the
      width of the internal auditory canal. The height of the internal auditory canal
      of type I is about 3 mm., that of type II is 3 to 5 mm., that of type III is 5 to
      7 mm., and that of type IV is over 7 mm.

PMID- 1034228
TI  - [A case of the anterior choroidal artery aneurysm combined with the abnormal
      intracranial vascular network (author's transl)].
AB  - A case of the anterior choroidal artery aneurysm combined with the abnormal
      intracranial vascular net-work was reported. The patient was 43-year-old male who
      was attacked by subarachnoid hemorrhage in February 25th 1975. When he was
      admitted to our clinic 30 days after the ictus, his general status was good and
      the neurological examination showed no particular findings except only slightly
      accelerated deep tendon reflexes on the left side. Cerebrospinal fluid still
      remained xanthochromic although no nuchal rigidity was denoted. Based on the
      angiographic four vessel studies, the circulatory condition of the patient's
      brain was summarized as follows; the internal carotid arteries were stenosed or
      occluded between the C1 and C2 segment on both sides, and abundant collateral
      circulation was developed mainly around the circle of Willis making an
      angiographically peculiar vascular net-work in tha base of the brain. Another
      angiographic finding to be noticed was a berry aneurysm which originated from the
      distal part of the left anterior choirdal artery. No special treatment was
      performed on him. He was discharged without any neurological residuals. It would
      be difficult to find out any hemodynamic relationship between the occlusion of
      the internal carotid arteries and occurence of the aneurysm. But the abnormally
      dilated anterior choroidal artery might suggest that the vessel wall of this
      artery would be burdened in the abnormal distension stress due to the increased
      transaxial pressure in this artery. Unqder such a hemodynamically stressed state,
      it would be possible the aneurysm like outpouching of the vessel wall being
      developed in some fragile portion of the artery functioning as a prominent
      collateral circulation.

PMID- 1034229
TI  - [Intracranial invasion of ethmoid cancer --a report of two cases (author's
      transl)].
AB  - Two cases of intracranial invasion of the ethmoid cancer were reported. With
      additional six cases reported in Japan, the precise clinical course and
      pathophysiological findings of the disease were reviewed, and the following
      several points became clear; 1) The incidence of the ethmoid cancer was rare. 2)
      These were divided into main groups according to the onset of intracranial signs,
      such as the frontal lobe symptoms and I-VII cranial nerve involvement. The first
      group showed the intracranial symptoms early, and the second group late. 3) The
      tumor invaded the cranial cavity along the perineural sheeth of each cranial
      nerve mainly. 4) It was very difficult to identify the paranasal sinus of origin
      after invading the cranial cavity. 5) The prognosis was extremely poor. All cases
      were died within one and half year.

PMID- 1034230
TI  - [An infantile skull fracture followed by the enlarging of the fracture line
      ("enlarging skull fracture") (author's transl)].
AB  - We experience sometimes an infantile skull fracture which is followed by the
      skull fracture line and bulging of the fractured area day by day after the head
      injury. Since John Howship reported the case of the partial absorption of the
      right parietal bone, arising from a blow on the head in a child aged 9 month in
      1816, this phenomenon was variously described meningocele spuria, traumatic
      cephalohydrocele, leptomeningeal cyst, fibrosing osteitis, cerebrocranial
      erosion, traumatic meningocele, die wachsende Schadelfrakture, growing skull
      fracture, etc. So called "growing skull fracture" has generally the triad of the
      symptoms which are the parietal skull fracture in infancy or childhood, traumatic
      dural tears, and subsequent enlargement of the fractures. And it is said that the
      dural tear is an indispensable condition for the developing of the "growing skull
      fracture". But we recently had the case of a 14 day old male infant who had
      neither traumatic dural tear nor subdural hematoma, but the progressive enlarging
      of the fracture line in the left parietal bone. The authors suggest that there
      should be the difference between the growing skull fracture (with the dural teat)
      and the enlarging skull fracture (without the dural tear).

PMID- 1034231
TI  - [Traumatic false aneurysm and arteriovenous fistula involving the middle
      meningeal artery-a case combined with intracerebral hematoma (author's transl)].

PMID- 1034232
TI  - [Report of a case with enlargement of a small arterial sacculation (author's
      transl)].

PMID- 1034233
TI  - [Redundant nerve root syndrome-a case report (author's transl)].

PMID- 1034234
TI  - [Decompression of the optic nerve (author's transl)].

PMID- 1034235
TI  - [Vomiting in newborn, infants and children--differential diagnosis (author's
      transl)].

PMID- 1034236
TI  - [Surgery of vertebral aneurysms at the origin of PICA (author's transl)].
AB  - Thirteen cases of vertebral aneurysm at the origin of PICA (VA-PICA aneurysm)
      were operated on at the Department of Neurological Surgery of Kitano Hospital
      from March, 1970 through July, 1975. Those included 9 cases of saccular aneurysm
      and 5 cases of fusiform aneurysm (Table 1). The incidence of VA-PICA aneurysms
      among our whole series of intracranial aneurysms was 4.2%. Patients with
      subarachnoid hemorrhage were subjected to our routine 4 vessel angiography. For
      those with suspected vertebral aneurysm vertebral angiography was performed in a
      transoral projection. In this method, when the angle between the film and the
      horizontal plain of Frankfurt is fixed at 50 degrees, the origin of PICA is
      projected on the film between the upper and lower teeth line. Since X-ray beam
      falls vertically on the origin of PICA, the resultant vascular shadow is free
      from shortening, elongation and distortion, leading to precise demonstration of
      anatomical arrangement of the vessels. At surgery a lateral suboccipital incision
      was made. With the position of VA-PICA junction the surgical approach was
      slightly different. When the junction was located higher than the line between
      the lowest point of the occipital bone and the basion by 1 cm or more, the
      approach was made through the middle of the sigmoid sinus which was exposed by
      suboccipital osteoclastic craniectomy (mid-lateral cerebellar approach). When the
      VA-PICA junction was situated lower than the line by 1 cm or more, the operation
      was initiated at the upper limit of the lower one-third of the sigmoid sinus
      (lower-lateral cerebellar approach). Since VA-PICA junction is ventrally situated
      to the lower cranial nerves, surgical attack to the junction can be attained only
      through the space among the nerves. Two spaces are available for this direct
      attack. One is the space between the facial nerve, acoustic nerve and the group
      of vagal nerves. The other is between accessory nerve bundles or between the
      group of accessory nerves and the hypoglossal nerves. The former procedure is
      employed for reaching the aneurysm by mid-lateral cerebellar approach and the
      latter by lower-lateral cerebellar approach. In the patients in acute stage of
      ruptured VA-PICA aneurysm, hemisuboccipital craniectomy and laminectomy of the
      atlas were carried out for the purpose of decompression. Surgical procedures used
      included coating in 2 cases, trapping in 2, proximal ligation of the vertebral
      artery in 2 and neck clipping in 6. Two patients died due to grastrointestinal
      bleeding. Surgical complications noted were hypoglossal nerve palsy in 1 case
      mild sensory disturbance contralateral to the aneurysm in 3 cases. Those symptoms
      were thought to be caused either by direct injury to the lower cranial nerves or
      circulatory disturbance in the medullary branches of the vertebral artery. To
      eliminate those postoperative complications it is desirable to devise smaller
      aneurysm clips and smaller clip foreceps.

PMID- 1034237
TI  - [Experimental study of acute brain swelling under acute intracranial hypertension
      (author's transl)].
AB  - There are many problems about the cause, pathophysiology and treatment of acute
      brain swelling under intracranial hypertension frequently encountered in the
      neurosurgical clinics. Generally, rapid increase of the cerebral vasoparesis
      caused by unknown etiology is thought to be the main cause of acute brain
      swelling under intracranial hypertension. Moreover, disturbance of the cerebral
      venous circulatory system is discussed recently by many authors. But, research
      from the point of systemic respiration and hemodynamics is necessary for
      resolving these problems. This experiment was designed to study the effects of
      respiration and hemodynamics on the cerebral vasoparesis. METHOD: Using 22 adult
      dogs, acute intracranial hypertension was produced by epidural balloon inflation
      sustained at the level of 300 - 400 mmH2O. Simultaneously with measurement of
      intracranial pressure at the epidural space, superior sagittal sinus pressure,
      respirogram, systemic blood pressure (femoral artery), central venous pressure,
      common carotid blood flow, EKG and bipolar lead EEG were monitored continuously.
      The experimental group was divided by the respiratory loading into 5 groups as
      follows: control (6 cases), 10% CO2 hypercapnia (4 cases), 10% O2 hypoxia (4
      cases), stenosis of airway (5 cases), 100% O2-controled respiration (3 cases).
      RESULTS AND CONCLUSIONS: 1) Cerebral vasoparesis under acute intracranial
      hypertension took place earlier and showed more rapid progression in groups of
      stenosis of airway, hypercapnia and hypoxia than control group of spontaneous
      respiration in room air. No occurrence of cerebral vasoparesis was found out in a
      group of 100% O2 controlled respiration. It is proved that increased airway
      resistance or asphyxia, hypercapnia and hypoxia have strictly reference to the
      occurrence and progression of cerebral vasoparesis and for the prevention of
      cerebral vasoparesis, correct 100% O2 cont rolled respiration is effective. 2)
      From the hemodynamic change, the progression of rapid increase of cerebral blood
      volume with increase of blood volume in the superior sagitta sinus during
      cerebral vasoparesis under intracranial hypertension is presumed. It is suggested
      from the superior sagittal sinus pressure in various experimental groups that the
      site, reactivity and disturbed degree of the cerebral venous system are changed
      by the difference of respiratory or ventrilatory state and the cerebral venous
      circulatory disturbance has also reference to the occurrence of acute brain
      swelling. 3) During cerebral vasopareris under acute intracranial hypertension,
      remarkable supression of respiration, increased central venous pressure and
      increased common carotid blood flow were observed. It is concluded that the
      reaction of systemic hemodynamics following respiratory change effects on
      cerebral circulation markedly and they are being important factors to occurrence
      of acute brain swelling.

PMID- 1034238
TI  - [Tentorial dural arteriovenous malformation--a case report (author's transl)].
AB  - A case of tentorial dural AVM was reported. A 52 years old man came to the Jichi
      Medical School hospital on July 29, 1974, with the chief complaints of
      intermittent left exophthalmos, diplopia and left blepharoptosis, which had been
      noted since March of 1974. He had episodes of severe headache attack since 3
      years prior to the hospital visit. Angiography done at the out-patient department
      demonstrated the dural AVM with the nidus in the left tentorium. The nidus was
      fed by the left posterior middle meningeal artery, the dural branch of the left
      occipital artery, the left posterior cerebral artery, the left superior
      cerebellar artery and the dural branches of vertebral artery. It was drained to
      the vein of Labbe and the two cortical veins of the occipital lobe. He was
      appointing admission under the diagnosis of dural AVM, but he had an apopleptic
      attack three days before the appointed date, so was admitted in emergency.
      Neurological examination on admission: The patient was in drowsy state,
      papilledema on the both sides and right hemiparesis including the face were
      noted. The bruit was not audible. Left CAG revealed intracerebral hematoma in the
      left tempotal lobe, so that the removal of the intracerebral hematoma and the
      middle meningeal artery ligation were carried out after his general condition
      improved, on October 18, 1974. On October 30, 1974, the second operation was
      performed in an attempt of the radical excision of the AVM nidud. But,
      unfortunately, the patient fell into the shock state so that the operation had to
      be stopped at the stage of the ligation of the feeders running in the dura of the
      posterior fossa. The third operation was done on February 19, 1975. The AVM nidus
      was removed with the left transverse sinus and a part of tentorium. He was
      discharged on March 3, 1975, with only the right homonymous hemianopsia. Nine
      months after his discharge, there was no sign of recurrence of AVM. PATHOLOGICAL
      FINDINGS: The left transverse sinus was almost occupied with AVM tissue. The
      endothelium of arteries were hypertrophied and the internal elastic bnadles were
      partly defected. Veins showed also hspertrophy of the endothelium and the
      thrombus formation. The dural AVM of the posterior fossa is not a rare malady,
      especially in the recent years, probably due to the technical advances in the
      roentgenology, such as magnification techniques as well as selective arterial
      catheterization. The most common signs and symptoms of this disease picked up
      from the reports of 112 cases in the literature are: bruit 47%, headache 44%,
      papilledema 26% and SAH 24%. The extra cranial ligation of feeders were
      reportedly carried out on 39 cases, but only 9 cases (23%) were effective.
      Therefore, the radical excision of the nidus would be the most desirable method
      for the complete treatment of the dural AVM.

PMID- 1034239
TI  - [A case of the lateral ventricular tumor (subependymal glomerate astrocytoma)
      with preceding Parkinsonian symptoms due to normal pressure hydrocephalus
      (author's transl)].
AB  - Authors report a patient with a subependymal glomerate astrocytoma in the right
      lateral ventricle. He maifested parkinsonian symptoms and dementia related to the
      preceding normal pressure hydrocephalus which was proved by an infusion test, and
      then advanced an akinetic mutism. Soon after a shunting operation was carried out
      he showed a full recovery from the symptoms, which may suggest that an incomplete
      block of the ventricular system is one cause of the normal pressure
      hydrocephalus. From pathology it was revealed that the tumor is an
      intraventricular astrocytoma with a fibrous stalk and was totally removed with an
      ease. The findings seem to accord with "Subependymal glomerate astrocytoma"
      (Boykin.) Further corroboration would be necessary to establish this entity.

PMID- 1034240
TI  - [Delayed radiation necrosis of the brain simulating a brain tumor--report of two
      cases (author's transl)].
AB  - Two cases of delayed radiation necrosis of the brain were reported. Case 1 was a
      50-year-old man who had right hemiparesis and disorientation 26 months after
      Linac irradiation (5,000 rad), preceded by the operation for right maxillar
      carcinoma. A left carotid angiogram demonstrated a left temporal mass lesion,
      extending the frontal lobe. Case 2 was a 41-year-old man who had previously the
      operation for right intraorbital plasmocytoma, followed by two times Co
      irradiation (6,400 rad, and 5,000 rad). He had the signs and symptoms of
      intracranial hypertension 36 months after last irradiation. A left carotid
      angiogram demonstrated a left temporal mass lesion. Both cases were treated by
      administration of steroid hormone, which alleviated the signs and symptoms,
      followed by the temporal lobectomy. Microscopic examinations showed necrosis of
      the brain tissues associated with hyaline degeneration of blood vessel walls and
      perivascular cell infiltration. The signs and symptoms of intracranial
      hypertension subsided postoperatively. The other thirteen cases as same as ours
      were collected from literature, which showed the signs and symptoms simulating a
      brain tumor (like a metastic brain tumor) after the irradiation to extracranial
      malignant tumors, and the diagnosis of radiation necrosis were made by the
      operation or autopsy. A follow-up for a long time is necessary, because the
      pathological changes in the brain may be progressive and extending in some cases,
      although the decompressive operations for mass lesion are excellent in result.

PMID- 1034241
TI  - Suckling and LH-induced progesterone secretion in lactating hamsters
      (Mesocricetus auratus).
AB  - The effects of suckling and LH upon serum progesterone levels in lactating
      hamsters were investigated. Diurnal rhythms in serum levels of progesterone and
      LH occur throughout lactation in the hamster and these levels are normally higher
      between 15.00 and 17.00 than between 8.00 and 12.00 (lights on 6.00-20.00).
      Hamsters injected with 10 mug of LH at 8.00 on day 9 of lactation had higher
      levels of serum progesterone 2 h after injections than did vehicle-injected
      controls. Suckling was also found to induce an increase in serum progesterone
      concentrations. 30 min of suckling from 10.30 to 11.00 on days 10 or 11 of
      lactation resulted in increased serum levels of progesterone and prolactin, but
      had no measurable effect upon serum LH levels in animals bled at 11.00. However,
      suckling for 30 min from 15.00 to 15.30 had no effect upon serum progesterone
      levels, although it did result in increased titers of both serum LH and prolactin
      at 15.30. Ovariectomy on day 7 of lactation resulted in lowered levels of serum
      progesterone at 11.00 on day 11 of lactation and abolished the suckling-induced
      increase in serum progesterone concentrations. These findings suggest that in the
      lactating hamster (1) suckling bouts stimulate progesterone secretion from the
      ovaries, and (2) the diurnal rise in serum progesterone levels is stimulated in
      part by the increase in serum levels of LH.

PMID- 1034242
TI  - Neonatal hydrocortisone: effect of the development of the stress response and the
      diurnal rhythm of corticosterone.
AB  - Neonatal rats were given s.c. injections of 1 mg of hydrocortisone acetate, and
      the effect on the subsequent development of the pituitary-adrenal response to
      ether stress and the development of the circadian rhythm in adrenal and serum
      corticosterone (B) was investigated. Following exposure to ether, adrenal
      steroids were elevated in 11-day-old controls. The response did not appear in
      treated animals until 25 days. At this age, the time-course of response to ether
      in the adrenal was more sluggish in hormone-treated rats. After stress, serum
      corticoids were high in controls at 20 days; however, this rise did not appear in
      treated rats until 25 days. Serum corticoids, 5-60 min after ether, tended to be
      lower in 25-day-old runts than in controls. The diurnal rhythm in serum B first
      appeared in controls at 27 days and in treated animals at 30 days. The rhythm in
      adrenal corticoids appeared in both groups at 30 days.

PMID- 1034243
TI  - Effect of neuroleptic drugs on mouse jumping induced by L-DOPA in amphetamine
      treated mice.

PMID- 1034244
TI  - [An old problem for modern gynecology: carcinoma of the endometrium. Diagnostic
      aspects].

PMID- 1034245
TI  - [Prevention of pelvic complications in radical hysterectomy].

PMID- 1034246
TI  - Anterior segment ischemia and sector iris atrophy: after strabismus surgery in a
      patient with chronic lymphocytic leukemia.
AB  - A 69-year-old woman with chronic lymphocytic leukemia developed segmental iris
      atrophy and iridocyclitis after routine surgery for exotropia. Both the clinical
      picture and fluorescein angiogram indicated anterior segment ischemia. It is
      postulated that this was related to hyperviscosity of the blood caused by a high
      white blood cell count (114,000/cu mm). The possibility of anterior segment
      ischemia should be kept in mind when contemplating strabismus or retinal
      detachment surgery in the presence of hematologic disorders likely to increase
      blood viscosity. In these cases a minimal amount of surgery should be done with
      proper supportive therapy. Strabismus surgery should be done in stages allowing
      for hemodynamic compensation between procedures.

PMID- 1034247
TI  - Scanning electron microscopy of the endolymphatic sac epithelium.
AB  - In this study, scanning electron micrographs of the dog endolymphatic sac surface
      epithelium are presented. According to our morphological findings, three portions
      were recognized, the proximal, intermediate and distal part. The intermediate or
      'rugose' portion was found the most differentiated where two types of cells were
      identified. These cells were seen to have many of the criteria for fluid
      absorption and phagocytosis. In man, alteration in the ability of these cells may
      lead to endolymphatic hydrops.

PMID- 1034248
TI  - Histological findings in infantile otoantritis.
AB  - The histopathological findings in the granulation tissue removed at mastoidectomy
      from 34 infants between 1971 and 1974 are described. Granulation tissue was
      present in every case, characterized by the histological features of chronic
      inflammation and fibrosis (sclerosis), although the process was of short
      duration. The great number of thick fibers was a surprising finding. To prevent
      fibrosis (sclerosis) to develop later on, it is advisable to operate as early as
      indicated.

PMID- 1034249
TI  - Emergency repair of traumatic drum tears.
AB  - Tympanic membrane tears have been found in about 20% of casualties in modern
      combat (war of October 1973). Repair of the tears that do not seem to have the
      optimal chances for spontaneous healing should be undertaken during the first few
      days of trauma. This prompts healing, prevents complications, and obviates the
      need for future intervention.

PMID- 1034250
TI  - Symptoms and signs of acute maxillary sinusitis.
AB  - Symptoms and signs of acute maxillary sinusitis have seldom been specifically
      analyzed. Since there is a gradual transition from rhinitis to sinusitis it can
      be expected that many symptoms are common for the two diseases. However, since
      sinusitis requires drainage measures and/or antibiotic treatment, both of which
      seldom are actual for rhinitis, the differential diagnosis is important. The
      present investigation confirms most of the symptoms presented previously in
      textbooks. However, most of these sympatoms which conventionally are supposed to
      indicate sinus disease were found to be just as common in radiologically normal
      sinuses and in sinuses with pronounced changes. The subjective or objective
      finding of purulent nasal secretion was more helpful in the differentiation
      between rhinitis and sinusitis. It appears that the patient's symptoms do not
      constitute a reliable diagnostic basis for the confident differentiation between
      the two diseases. The simplest and least discomfortable means of demonstrating
      sinusitis is by radiology.

PMID- 1034251
TI  - [Late results in the removal of vocal-cord polyps].
AB  - A follow-up of 60 patients in whom polyps of the vocal cord have been removed
      between 1966 and 1974 is analyzed. Two thirds of the patients were male, mostly
      between 30 and 55 years of age. Most of the female patients were between 25 and
      60. The most frequent localization was the typical one between the anterior and
      middle third of the vocal cord (47 patients). In 38 patients a direct
      laryngoscopy in local anaesthesia was performed; in 22 the removal of the polyps
      was done in microlaryngoscopy under general anaesthesia. The follow-up shows no
      recurrence. 55 patients had a clear voice, the remaining 5 showed signs of
      chronic laryngitis. It is concluded that microlaryngoscopy under general
      anaesthesia is indicated in cases of unfavourable anatomical configuration of the
      neck, sessile polyps or in cases where precise endoscopical manipulations are
      called for. The direct laryngoscopy remains an approved method in favourable
      cases, for instance pendular polyps, as these represent an affection of the vocal
      cord which shows no tendency to recurrence after mediculous removal.

PMID- 1034252
TI  - [Velo-pharyngeal closure before and after adenotomy and tonsillectomy].
AB  - Prior to and after removal of the tonsils and adenoids at the ENT clinic in
      Lucerne, phoniatric and X-ray examinations were performed in 42 children with
      normal velo-pharyngeal closure. Prior to the operation the velo-pharyngeal
      closure took place against the adenoid tissue. The surface of contact and the
      inclinatation of the velum were dependent on the amount of hyperplastic adenoid
      tissue. The configuration and the mobility of the velum were more important for
      the post-operative velo-pharyngeal closure than the distance from the pharyngeal
      wall. 3 months following the operation the velum was reaching the posterior
      pharyngeal wall. A distinct Passavant ridge was only visible in cases having
      slight difficulties in the post-operative adaptation of the velo-pharyngeal
      closure.

PMID- 1034253
TI  - [Spastic dysphonia].
AB  - Between 1968 and 1974 10 patients (4 men, 5 women, and 1 10-year-old girl) with
      spastic dysphonia were observed at the Phoniatric Department of the ENT clinic in
      Lucerne. According to the clinical documentation, the probable etiologic factors,
      the clinic appearance as well as the therapeutic measures and their results are
      discussed.

PMID- 1034254
TI  - [Approach and reconstruction in the operative treatment of tumors of the tongue,
      epiglottis, floor of the mouth and pharynx].
AB  - This paper explains a new way of a temporary splitting of the lower jaw and the
      reconstruction of the tongue and the floor of the mouth. The described way of the
      temporary splitting of the lower jaw allows to maintain the nerve and results in
      better suppositions for the reposition and osteosynthesis. For the reconstruction
      of the tongue and the floor of the mouth, an island flap is reommended. The flap
      consists of the musculus sternocleidomastoideus, pedicled inferiorly in its
      cranial part of the skin. The skin taking extends over the insertion of the
      muscle up to the beginning of the hairy part. With this flap it is possible to
      cover even large defects in the floor of the mouth and its taking does scarcely
      bother the patient. Thus, in many cases the flap gives the suppositions to
      maintain the lower jaw.

PMID- 1034255
TI  - [Modification of a technic of reconstruction after total or subtotal resection of
      the lower lip].
AB  - It has been shown that two different kinds of modification are able to improve
      Meyer's operation after subtotal or total ablation of the lower lip. Either a
      flap taken from the top of the tongue or the Estlander-Abbe's triangular flap can
      be used in the intention of widening the new lip and consequently avoiding an
      excess of tension of it.

PMID- 1034256
TI  - [Cervico-facial lesions caused by windshields of tempered glass].
AB  - The authors stress the dangers presented by windshield fragments of tempered
      glass to soft parts of the cervicofacial region, in cases of traffic accidents.
      With the aid of seven recent clinical observations, the difficulties in emergency
      surgical treatment, late complications due to the persistence of foreign bodies,
      and permanent facial mutilations are successively discussed.

PMID- 1034257
TI  - [Rupture of the aorta secondary to perforation of the esophagus by a foreign
      body].
AB  - A case of traumatic rupture of the aorta due to a foreign body in the esophagus
      is presented. After extraction of the foreign body and chemotherapy there was a
      rapid recovery. Thereafter, the patient died from a recurrent hematemesis. Two
      factors have produced the aortic lesion: the sharp edge of the foreign body
      (which probably provoked a superficial lesion of the aortic wall), and the
      diffuse mediastinitis (which provoked a necrosis of the aortic lesion).

PMID- 1034258
TI  - [Clinical aspects of leishmaniasis].
AB  - Report of an extremely rare localization of leishmaniosis with primary affection
      of the hard palate. The diagnostic methods, differential diagnosis and therapy
      are discussed.

PMID- 1034259
TI  - [Differential diagnosis of salivary disturbances by quantitative scintigraphy].
AB  - The scintigraphy of salivary glands with technetium-99m pertechnetate is
      predisposed to be an excellent test for evaluating salivary gland function. But
      the absence of a sufficiently precise and simple quantitative analysis procedure
      of the technetium uptake has reduced its clinical use. For this reason, the
      authors propose a new and quick method:  the quantitative salivary gland
      scintigraphy. With an uptake index (ratio of technetium uptake between the
      glandular tissue and a cervical reference) they get precise quantitative
      information on functional activity. Among other applications, the test allows to
      make within a few minutes, in a case of xerostomia, the differential diagnosis
      between Sjaogren syndrome and sialosis.

PMID- 1034260
TI  - [Xerography in otorhinolaryngology].
AB  - This study compares, in the field of oto-rhino-laryngology, the xerography (a
      radiographic method recently introduced in the Cantonal Hospital of Geneva) with
      conventional radiography. In spite of the quantity of irradiation which is by far
      superior, the xerography, with its larger field of information and with its
      sharpness of outlines, permits a more precise topographic diagnosis, particularly
      as far as the pharyngolarynx is concerned.

PMID- 1034261
TI  - [Futher experimental studies on the relationship between the stapedius reflex
      threshold and speech discrimination].
AB  - This paper discusses the functional relatiohship between the position of the
      stapedius reflex threshold and the results of the Feldmann test. 25 hearing
      impaired patients have been examined in this respect. A positive correlation on a
      5% level of significance has been confirmed between these two parameters.

PMID- 1034262
TI  - [Clinical significance of preoperative impedance measurements].
AB  - On the basis of six particular cases in which the various impairments of the
      middle ear were verified during the surgical intervention, the authors show how
      it is possible to obtain by means of the Madsen ZO 70 electroacoustic impedance
      meter and of the Grason-Stadler Model 1720 otoadmittance meter useful additional
      information about the preoperative dynamic behavior of the tympano-ossicular
      system. With regard to the measurement of 'susceptance' and the 'conductance' at
      220 and 660 Hz, it permits to establish a better differential diagnostic.

PMID- 1034263
TI  - [Change of working place in occupational noise].
AB  - Nowadays noise in industry cannot be eliminated by technical means alone.
      Therefore, exposed workers have to wear an ear protector to prevent the
      occurrence of deafness caused by professional noise. Patients with chronic otitis
      media and permanent or intermittent otorrhea should avoid the prolonged use of
      ear protectors. On principle, such patients are not allowed to work in a noisy
      environment (inaptitude for noisy employment/change of occupation) unless the
      contraindication for use of ear protectors can be eliminated by therapeutic means
      (such as operation).

PMID- 1034264
TI  - [Meningitis and labyrinthitis in childhood].
AB  - The Haemophilus influenzae meningitis is the most common cause of deafness
      following meningitis. Five of 22 children (23%) had this complication in spite of
      antibiotic treatment (ampicillin). The question must be raised whether a
      different antibiotic treatment could avoid the inner-ear problems occurring in
      Haemophilus influenzae meningitis. Early decompression of the internal auditory
      canal has reversed deafness in one of four children.

PMID- 1034265
TI  - [Tympanoplasty and congenital cardiopathies].
AB  - During the course of 1974, 16 tympanoplasties were performed on patients who
      suffered from serious congenital heart defects. 50% of the cases had recurrence
      of the perforation. It was not possible to deny the evidence of other failing
      factors such as the poor hemodynamic condition. Indications for performing a
      tympanoplasty were motivated by the necessity to eliminate a focus of dangerous
      infection to the patient before under-going a major cardiac intervention. These
      indications have been modified to the following: (a) chronic cholesteatomatous
      otitis remains a valid surgical indication and (b) simple chronic otitis could be
      controlled by local medical treatment. The tympanoplasty could be postponed after
      the cardiac intervention when the hemodynamic condition had been corrected.

PMID- 1034266
TI  - [Radiologic aspects of temporal-bone fractures with facial paresis].
AB  - The value of the radiobiological diagnosis in establishing the localization of a
      facial palsy resulting from temporal bone fractures has been investigated in 49
      cases. Radiological confirmation was found in 21 out of 37 cases of longitudinal
      fracture and in 11 out of 12 patients (90%) with a transverse fracture. The
      fracture line was seen by polytomography alone in 1 out of 21 (5%) longitudinal
      fractures and in 5 out of 11 (45%) transverse fractures. A precise readiological
      localization of the facial nerve lesion was only possible if the fracutre line
      was running across the long axis of the pyramid. The surgical revision of 37
      patients has shown that the labyrinthine segment of the facial nerve was injured
      in 93% of longitudinal fractures and in 70% of the transverse fractures.
      Therefore, one should always be prepared to expose the labyringhine segment of
      the facial nerve when revising a facial nerve palsy due to a fracture of the
      temporal bone.

PMID- 1034267
TI  - [Experimental studies on the suppression of the stapedius reflex in comparison
      with EMG-results in idiopathic facial paresis].
AB  - The recording of intra-aural muscle reflexes elicited by acoustic stimulation is
      a routine method in clinical audiology. The most important quantitative
      examinations of the reflex dynamic, i.e. Metz recruitment and reflex decay in low
      frequencies, allow the judgement of function of the afferent pathway in the
      stimulated inner ear and acoustic nerve. Quantitative determinations of the
      efferent branch were carried out by several authors in a few normal subjects and
      in several patients with multiple sclerosis or facial palsy. Absolute acoustic
      impedance - a method yielding wide scattering - was used in order to determine
      changes in reflex activity in pathological conditions. In the first part of our
      investigations we tried to find a parameter or reflex dynamic allowing to
      characterize the functional capacity in the efferent part of the reflex arch in
      the facial nerve. We examined particularly the steepness of the onset of recorded
      reflex. Statistical analysis showed an extraordinary stability of this parameter
      in normal and pathological conditions. Measurements in normal subjects yielded
      very small intra- and inter-individual variability. In the second part of our
      experiments we studied normal-hearing patients with unilateral Bells palsy. In
      the early phase of the lesion we found a significant decrease of the onset
      steepness in the reflex diagram recorded on the paralyzed side. The greatest
      reduction of this parameter was seen with a 1,000-Hz stimulus. The time course of
      the alteration of the onset steepness also seems to have a characteristis
      pattern. In a further investigation we compared the variations of this reflex
      parameter with findings in stimultaneously recorded electroneuronograms.

PMID- 1034268
TI  - [Tissue adhesives in facial-nerve surgery].
AB  - Large amounts of the tissue glue Histoacryl applied over the circumference of the
      epi- and perineurium of the facial nerve produced a rapid decrease of the
      summation potentials of the face in acute and chronic experiments performed in
      cats and guinea pigs. No toxic action on the motor neurons of the facial nerve
      was seen after application of 1 or 2 drops of the tissue glue over the epi- or
      perineurium of the facial nerve in association with or without a collagen tube
      splint.

PMID- 1034269
TI  - [Treatment of posterior epistaxis by ligation of the internal maxillary artery in
      the pterygo-maxillany fossa].
AB  - The microsurgical, transantral ligature of the internal maxillary artery is the
      treatment of choice for recurring posterior epistaxis. An immediate success was
      obtained by this method in 5 out of 7 patients. In one case the concomitant
      coagulation of the ethmoidal arteries was necessary and in another instance a
      revascularization of the spheno-palatine artery could be visualized by
      arteriography.

PMID- 1034270
TI  - [Extirpation of nasopharyngeal fibromas after selective preoperative angiographic
      embolization].
AB  - The gross amount of bleeding during surgical removal of nasopharyngeal
      angiofibromas is feared. An excellent method to reduce this amount is the
      preoperative selective embolization of the feeding vessels of these tumors under
      angiographic control. The advances in selective angiography of the branches of
      the external carotid artery by femoral catheterization make it possible to
      applicate Gelfoam emboli in the very arteries which are to be embolized. There is
      a case report about two young men who have been pretreated in this manner. The
      intraoperative bleeding was minimal.

PMID- 1034271
TI  - [Tympanometry in chronic otitis media].
AB  - We present an analysis of the otological and audiological findings in 63 patients
      (113 ears) in which a myringotomy for suspected serous otitis media has been
      performed. In 98 ears (87%) the impedance data correlated with otoscopy.
      Tympanograms did not give further information than otoscopy alone in 49 patients
      with reliable pure-tone audiometrical results, whereas tympanograms would have
      missed 6 out of 78 ears containing fluid and 6 out of 49 ears who improved in
      hearing following myringotomy and transtympanic tube therapy. We feel, however,
      that, in patients who are too young or too retarded to be tested audiometrically,
      tympanometry in combination with otoscopy could eventually be helpful in settling
      the indication for a myringotomy, since 3 out of 83 ears with middle ear fluid
      and hearing improvement following transtympanic tube therapy had pathological
      tympanograms in spite of normal-seeming ear drums.

PMID- 1034272
TI  - [Vocal and laryngo-tracheal sequelae of prolonged intubation at the university
      medical clinic of the cantonal hospital at Lausanne].
AB  - 70 patients (39 men and 31 women) submitted to a prolonged intubation at the
      Centre respiratoire de la Clinique medicale universitaire de Lausanne have been
      investigated. They represent the half of the patients having survived of 488
      cases treated between January 1966 and June 1974. 33% of the investigated
      patients (i.e. 18% of all men and 48% of all females) complain about a permanent
      dysphonia related to the intubation. 17% of the patients (i.e. 13% of all men and
      23% of all females) presented with a laryngotracheal lesion induced by the
      prolonged intubation. This study shows that laryngo-tracheal complications
      following prolonged intubation are more frequent in females than males. The time
      of intubation is a determinant factor for the development of complications.
      Following the first 48 h or intubation of the risk of laryngo-tracheal
      complication is proportional to the duration of the permanence of the nasal tube.
      The presence of pathogenous microbes (Klebsiella, Staphylococcus aureus,
      Bacterium coli, Proteus, Pseudomonas aeruginosa) in the tracheo-bronchial
      secretion is also important for the development of sequelae. In conclusion,
      laryngo-tracheal complications following prolonged intubation occur in the male
      when predisposing factors are present, whereas in the female post-intubation
      sequelae occur without such predisposing factors.

PMID- 1034273
TI  - The importance of perinatal care.

PMID- 1034274
TI  - Perinatal mortality and morbidity in breech deliveries at the Dr. Cipto
      Mangunkusumo General Hospital, Jakarta.

PMID- 1034275
TI  - Medical education at Teheran University: An evaluation of study habits and
      students' attitudes.

PMID- 1034276
TI  - The role of prostagandins in the control of uterine blood flow.

PMID- 1034277
TI  - Variability of blood pressure in normal and abnormal pregnancy.
AB  - Using an automatic indirect method of measurement, diurnal blood  pressure
      patterns have been studied in normal and hypertensive pregnancies. In the last
      trimester, normotensive and hypertensive pregnant subjects show small but
      significant increases of blood pressure that develop especially during the
      evening and night. This change is more clear-cut for the systolic than the
      diastolic pressure. The tendency to a relatively greater increased pressure at
      night is exaggerated in preeclampsia. This fact explains earlier observations of
      a dimunution of the nocturnal fall of blood pressure in preeclampsia. In very
      severe preeclampsia, the nocturnal increase of blood pressure may be so
      exaggerated as to reverse the normal diurnal blood pressure pattern. These
      changes have been documented sequentially, and their implications are discussed
      briefly.

PMID- 1034278
TI  - Responses of Purkinje cells in rabbit nodulus and uvula to natural vestibular and
      visual stimuli.
AB  - 1. The responses of Purkinje cells and presumed mossy fibers to natural
      stimulation of the horizontal semicircular canals were recorded in the nodulus
      and uvula of rabbit vestibulocerebellum. Units responding to vestibular
      stimulation were also studied with visual stimulation. 2. The responses of
      presumed mossy fibers were of the Type I and Type II varieties and were
      characterized by a low threshold for angular acceleration and high sensitivity.
      3. Purkinje cell responses were divided into two groups: The first group showed
      only modulation of simple spike activity during rotation. According to the
      directionality of their responses to rotation, Purkinje cells of the first group
      could be further subdivided into Types I, II or III; Type II was the most
      frequently encountered. The second group showed modulation of both simple spike
      and climbing fiber activity. The simple spike response most frequently
      encountered was of Type II while the climbing fiber activity in the same Purkinje
      cells responded in the Type I mode. In another population of Purkinje cells of
      this group, simple spike activity was modulated by rotation in one direction
      only. All Purkinje cell responses had relatively high thresholds and low
      sensitivities. 4. Some Purkinje cells responding to rotation showed direction
      selective modulation of climbing fiber discharge in response to slowly moving
      visual patterns.

PMID- 1034279
TI  - Alterations during postnatal period in the secretory responsiveness of the sweat
      glands in rats to mecholyl.
AB  - A study was made to know the alterations in the secretory responsiveness of the
      plantar and palmar sweat glands to local administration of mecholyl in rats
      during postnatal period. Nonresponsiveness of the plantar and palmar sweat glands
      to mecholyl was observed in 0- to 16-day-old and 0- to 10-day-old rats,
      respectively. After the nonresponsive period, a gradual increase in the
      responsiveness to mecholyl was observed in the plantar sweat glands. In the
      palmar sweat glands, however, a rapid increase followed by a temporary decrease
      and a subsequent gradual increase in the secretory responsiveness to mecholyl was
      found. This temporary decrease in the secretory responsiveness was observed on
      days soon after weaning.

PMID- 1034280
TI  - Climbing fiber evoked potassium release in cat cerebellum.
AB  - K+-selective micropipettes were used to measure the extracellular K+-signal
      associated with the activation of a single Purkinje cell, via a climbing fiber
      (CF). The maximum K+-signal had a magnitude of 0.3 - 0.5 mM and was correlated
      with a positive all-or-none extracellular potential. The ionic signal was of the
      same order of magnitude as that evoked from a population of Purkinje cells by
      local stimulation of a parallel fiber beam. The large size of the CF-evoked K+
      response supports the concept of dendritic spikes under these conditions and may
      be relevant to CF function.

PMID- 1034281
TI  - Paradoxical changes of respiratory rate elicited by altering rostral brain stem
      temperature in the pigeon.
AB  - Intermittent panting was induced in conscious pigeons by exposure to warm ambient
      conditions. Cooling of the rostral brain stem elicited temporary increases of
      respiratory rate, the extent of which depended on precooling respiratory rate and
      body temperature, respectively. Hypothalamic heating elicited a temporary
      suppression of intermittent panting.

PMID- 1034282
TI  - Determination of glomerular intracapillary and transcapillary pressure gradients
      from sieving data. 3. The effects of angiotensin II.
AB  - The effects of the intrarenal infusion of synthetic Asn1, val 5 angiotensin II
      (AII) (from 0.38 to 1 mug min-1) on the determinants of glomerular filtration
      have been studied. The intracapillary and transcapillary pressure gradients along
      the capillaries, together with 2 parameters characterizing the porosity of the
      membrane in terms of pore theory (r, radius of the pores and Ap/1, total pore
      area per unit of path length) were calculated from the analysis of the sieving
      curve of I125 PVP molecules (polyvinylpyrrolidone) according to a biomathematical
      model previously described. AII increased PGC, the intracapillary hydrostatic
      pressure, but more at the efferent end of the capillaries. Filtration pressure
      equilibrium was maintained. AII also decreased the water permeability
      coefficient, Kf. by decreasing Ap/1, r remaining constant. Our results were
      compared to those obtained from the direct measurements of PGC, using
      micropuncture techniqles in hydropenic and plasma loaded rats. The complete
      agreement between the two approaches confirms the validity of the method based on
      the analysis of the sieving data of neutral macromolecules to calculate the
      determinants of GFR.

PMID- 1034283
TI  - Lingual blood flow and its hypothalamic control in the dog during panting.
AB  - 1. The effects of increased ambient temperature (Ta) on blood-flow and 
      temperatures of the tongue were studied in the unanaesthetized dog. At Ta of 20
      degrees C and a relative humidity (rh) of 30% the mean lingual blood flow was 11
      ml-min-1 (0.15 ml-g-1-min-1) and the temperature difference between the lingual
      artery and vein (deltaTLAV) was 1.0 degrees C. Accordingly, a heat loss of 48.6 J
      min-1 was calculated even for the dog breathing with the mouth closed. When Ta
      was elevated to 38 degrees C at constant rh, panting ensued. In parallel fashion
      lingual blood flow increased to 60.4 ml-min-1 (0.81 ml-g-1-min-1) in mean and to
      74.7 ml-min-1 (0.99 ml-g-1-min-1) at peak rate of thermal tachypnoea (272 breaths
      min-1). This flow increase resulted from a decrease in the local vascular
      resistance since the driving systemic pressure remained constant. It was
      accompanied by an increase in TLAV to 1.5 degrees C equivalent to a heat loss of
      400.7J-min-1 in mean and 496.2J-min-1 at maximum respiratory rate. 2. The
      preoptic/anterior hypothalamic (PO/AH) region was heated with a water perfused
      thermode in urethane anaesthetized dogs at constant body temperature in order to
      study the relationship in time between the increase in lingual blood flow and the
      onset of thermal panting. Lingual blood flow was found to be 20 ml-min-1 at a
      respiratory rate of 60 breaths/min. During hypothalamic heating both respiratory
      rate and lingual blood flow increased markedly. At maximum respiratory rates (244
      breaths-min-1) lingual blood flow reached a level of 60 ml-min-1. When perfusion
      of the thermode was stopped, both respiratory rate and lingual blood flow
      synchronously returned to control values within 5 min. Similar changes did not
      occur in dogs in which a ventilatory response failed to be elicited during
      hypothalamic heating. 3. The results suggest that the tongue contributes to the
      evaporative heat loss mechanism and they confirm the concept that panting,
      associated with increased lingual blood flow, is induced by a common autonomic
      outflow pattern which is mediated by the central mechanism controlling thermal
      homeostasis.

PMID- 1034284
TI  - Activation of anaerobic metabolism in cat skeletal muscle during cholinergic
      sympathetic vasodilatation.
AB  - Phosphorylase activity was found to increase 2-fold as compared with the control
      value (79% and 39% respectively) within the first 2-3 s of the vasomotor effect
      elicited in the skeletal muscle by sympathetic stimulation. Phosphorylase
      activity was still high during the period of maximum blood flow, although to a
      lesser extent (54% and 45%). During the phase of restoration of the initial rate
      of blood flow the values of phosphorylase activity were the same in the
      experimental and the control sample. The AMP content did not increase with the
      initiation of the vasomotor effect, and this fact suggests that the increase in
      phosphorylase activity is due to an increase in phosphorylase "a" rather than to
      the activation of phosphorylase "b" by AMP. Atropine blocks both the dilator
      effect and phosphorylase activation elicited by sympathetic stimulation.
      Acetylcholine, injected intraarterially or added to a muscle homogenate,
      increases phosphorylase activity. It is concluded that acetylcholine, released by
      sympathetic nerve endings, performs a second mediator function, that of
      activating anaerobic metabolism in the skeletal muscle. The two mediator
      functions of acetylcholine seem to be spatially delimited.

PMID- 1034285
TI  - Blood flow and transport of free fatty acids in striated muscle under chronic
      ischemia.
AB  - Three weeks of ischemia of the right hind limb in rat produced by ligature and
      severing of the right common iliac artery, resulted in changes in FFA transport
      and blood flow in the regenerating tibialis muscle. FFA transport was measured
      using i.v. administered palmitate-1-14C bound to albumin. Uptake of palmitate-1
      14C or 86Rb 90 s after i.v. administration was decreased in ischemic tibialis
      muscle, whereas no apparent effect of ischemia on the contralateral muscle was
      seen. Plasma FFA outflow rate measured according Beker and Rostami was not
      affected by the presence of an ischemic extremity in comparison with control
      animals. The plasma FFA inflow rate into the ischemic muscle was markedly
      decreased to values of 6.5 mmumoles FFA/min/g whereas in control animals values
      were 18.8 mmumoles FFA/min/g wet tissue. Decreased FFA inflow rate to the
      ischemic tibialis muscle was due to the decreased radioactivity of palmitate-1
      14C in the muscle under the conditions of a constant plasma FFA pool. Differences
      in the uptake of palmitate-1-14C in tibialis muscle were dependent upon the
      muscle blood flow, which was markedly decreased in the ischemic muscle on
      indirect measurement with 86Rb or with the 133Xe clearance.

PMID- 1034286
TI  - [Ultra-slow changes in the rhythmic activity within the alpha band and their
      probable origin (author's transl)].
AB  - The time variation of spectral parameters of EEG data, from occipital and central
      regions, were analysed in normal subjects. Three-second segments, overlapping at
      1-s intervals, were studied as to their peakfrequency, bandwidth and power within
      the alpha band using an autoregressive model of 7th order. In addition, the EKG
      and respiration were also analysed. Beat-to-beat intervals from the EKG were
      measured to quantify underlying slow rhythms. Individual EEG parameters were
      found to change synchronously with respiration and also with the 6/min rhythms
      underlying the heart rate variation. These changes occurred most frequently only
      for a short time and they seldom appeared in several cortical regions
      simultaneously. In addition, the EEG parameters also changed synchronously with
      the repetition of a specific task (e.g., CNV paradigm) showing dependence from
      stimulus modality and from task complexity. Basically a decrease in power within
      the alpha band, sometimes together with a small increase or decrease of peak
      frequency, was shown to occur predominantly in that cortical area involved with
      processing of task-relevant information. Ultra-slow changes of the EEG parameters
      can be interpreted as changes in cortical excitability and responsiveness.

PMID- 1034287
TI  - The optical spike. Structure of the olfactory nerve of pike and rapid
      birefringence changes during excitation.
AB  - 1. Electron microscope studies on the olfactory nerve of the pike revealed a
      population of 4.2 million, densely packed unmyelinated nerve fibres; 95% are
      small fibres (average diameter 0.19 mum, narrow modal class), 5% are larger
      (average diameter 0.6 mum). Each fibre is bounded by an axonal membrane with a
      bilayer structure (80 A thickness). 2. The olfactory nerve is birefringent
      (negative with respect to fibre axis) and shows at 20 degrees C an average
      retardation R = 23 mn. The birefringence becomes more negative on lowering the
      temperature. 3. With the passage of an action potential a rapid, transient
      increase of retardation--the optical spike-- occurs; deltaR = 0.04 nm. The
      optical spike corresponds to the time course of structural changes in the axon
      membrane during excitation; it begins later, peaks earlier and decays more
      quickly than the voltage changes as recorded externally in the present study.

PMID- 1034288
TI  - Phase-plane analysis of action potentials in uterine smooth muscle.
AB  - Action potentials were recorded by microelectrode from narrow strips of pregnant
      rat uterus in vitro. The phase-plane display (V vs dV/dt) of selected action
      potentials was analysed by the method of Jenerick (1964) to yield the ionic
      current. From this membrane current data, various parameters of the action
      potential were calculated. In comparison to skeletal muscle action potentials,
      the ionic currents were 30-100 times smaller in the uterus action potential.
      Epinephrine hyperpolarized the resting potentials and suppressed spontaneous
      activity, but did not cause any significant changes in the stimulated action
      potential. The after-potential may have been affected by epinephrine, preventing
      repetitive firing, but the data were inconclusive. The phase-plane analysis
      results were similar to the results of the double sucrose gap voltage clamp
      method on the same tissue (Kao and McCullough, 1975).

PMID- 1034289
TI  - [Isotop cardiac pacemaker during pregnancy. 3 cases].
AB  - The authors report three cases of full term pregnancies, without complications,
      in women with isotopic pacemakers. The newborn infants were normal. In one case,
      pregnancy occurred in a patient who already had a pacemaker. In two cases, the
      pacemaker was inserted during pregnancy (at 1 and 1/2 and 5 months respectively),
      in the treatment of syncopal attacks due to paroxysmal atrioventricular block.
      This type of pacemaker using a radioactive source (Plutonium 238) is, by virtue
      of the low degree of radiation, harmless and may be used in women of childbearing
      age. Under the least favourable conditions (pacemaker box in abdominal
      situation), the dose delivered during pregnancy (57 mrem) is approximately 20
      times less than the authorised dose (1125 mrem).

PMID- 1034290
TI  - [What is the current status of experimental surgery in France?].

PMID- 1034291
TI  - [Current treatment of testicular cancers].
AB  - The treatment and prognosis of dysembryoma of the testis have been transformed by
      the dissection of retroperitoneal nodes and by combination chemotherapy as early
      as possible. Routine retroperitoneal node dissection followed by early and
      prolonged chemotherapy lead to a hope of cure in more than 75% of cases of
      dysembryoma of the testis. Similar early chemotherapy is effective and indicate
      for choriocarcinoma of the testis and retroperitoneal node dissection may be of
      value in tumours in which the chorial element is "minor".

PMID- 1034292
TI  - Sheared DNA fragment sizing: comparison of techniques.
AB  - DNA fragmented by conventional French press shearing procedures (30,000 lbs/in2)
      has a number-average fragment size of 230 base pairs. This is considerably
      smaller than the 450 base pairs typically reported for DNA sheared by this
      method. Comparison of 5 sizing techniques indicates that sheared DNA fragment
      size is overestimated by either measurement of velocity sedimentation or
      Kleinschmidt Electron Microscopic visualization. Both adsorption grid electron
      microscopic visualization and gel electrophoresis yield the most reliable
      estimates of the mean size of small DNA fragment populations. In addition, the
      assessment of fragment size distribution (not possible from sedimentation
      analysis) potentially allows more critical evaluation of DNA hybridization and
      reassociation kinetic and measurement parameters.

PMID- 1034293
TI  - The subunit structure of chromatin from Physarum polycephalum.
AB  - Nucleosome DNA repeat lengths in Physarum chromatin, determined by nuclease
      digestion experiments, are shorter than those observed in most mammalian
      chromatin and longer than those reported for chromatin of certain other lower
      eukaryotes. After digestion with staphylococcal nuclease for short periods of
      time an average repeat length of 190 base pairs is measured. After more extensive
      digestion an average repeat length of 172 base pairs is measured. Upon prolonged
      digestion DNA is degraded to an average monomer subunit length of 160 base pairs,
      with only a small amount of DNA found in lengths of 130 base pairs or smaller.
      Mathematical analysis of the data suggests that the Physarum nucleosome DNA
      repeat comprises a protected DNA segment of about 159 base pairs with a nuclease
      accessible interconnecting segment which ranges from 13 to 31 base pairs. The
      spacing data are compatible with measurements from electron micrographs of
      Physarum chromatin.

PMID- 1034294
TI  - [Scombroid poisoning].

PMID- 1034295
TI  - [Exposure of ovaries to radiation doses during hysterosalpingography].

PMID- 1034296
TI  - [Surgical treatment of popliteal artery injuries].

PMID- 1034297
TI  - [Experimental studies on the value of peritoneal tapping in the diagnosis of
      acute abdomen].

PMID- 1034298
TI  - [Value of specific IgE levels in the etiological diagnosis of asthma].
AB  - The authors report a study of skin and inhalation tests and of specific IgE in 76
      control subjects and 180 patients with allergic asthma. There is a remarkable
      correlation between the skin tests and the R.A.S.T. in pollinosis (96% of
      correlation) and in the respiratory allergy to Dermatrophagoides pteronyssinus
      (120 patients and 87.5% of correlation). It is good in the allergy to animal
      dander (82% of correlation) but poorer in the respiratory allergy to house dust
      (62% of correlation). The comparative study of inhalation tests and R.A.S.T.
      confirms that the degree of correlation depends on the quality of the allergens
      and on the patients selection. With the extract of house dust (101 cases) the
      correlation is only of 61.9%, whereas it reaches 95% with a purified extract of
      Dermatophagoides pteronyssinus (38 cases). The comparison between the treshold of
      allergenic sensitivity and the group of R.A.S.T. shows that to one group of high
      R.A.S.T. usually corresponds a low treshold of bronchial sensitivity (D.L.A.L.
      less than 100 gamma of extract of D. pt. in 22 patients having a R.A.S.T.D. pt.
      of group 3 or 4). Besides being valuable in characterizing allergens, the
      R.A.S.T. when confronted to the case history, to skin and inhalation tests,
      provides supplementary information leading to a more precise allergological
      diagnosis. In respiratory allergies caused by well known allergens (pollen,
      Dermatophagoides pteronyssinus), the R.A.S.T. could be substituted to skin and
      inhalation tests, when in agreement with clinical data. In doubtful cases, the
      inhalation tests would still keep their value and the confrontation of different
      techniques is necessary.

PMID- 1034299
TI  - [Catalytic activity of UDPAG-2-epimerase in the rat. Probable use in the
      differential diagnosis of diseases in man].
AB  - In this communication, we report, for the first time in the literature, on the
      presence of UD-PAG-2'-epimerase catalytic activity in various organs; i.e.
      kidney, brain, heart, testicle, and pancreas of rat (Mus norvegicus albinus) and
      the kinetical behavior of hepatic and renal activities are compared in a
      preliminary way. The subcellular distribution, the enzymatic stability at 4
      degrees C., the catalytical efficiency and stability as a function of pH, and the
      enzymatic activity and differential denaturation as a function of the temperature
      would allow to postulate on the existence of UDPAG=2'-epimerase isozymes. The
      medical importance of such a differential kinetical behaviour of UDPAG-2'
      epimerase as a function of its tissue origin is stressed, particularly in
      connection to the differential diagnosis, prognosis and treatment of various
      human diseases.

PMID- 1034300
TI  - [Rabies (author's transl)].

PMID- 1034301
TI  - [Chemical composition of different sorts of soybeans and changes under the
      influence of weather and soil-climatic conditions].
AB  - The biochemical composition (the content of protein and lipids, the content of
      essential amino acids in the protein complex, the fatty acid composition of
      lipids) of seeds of eighteen soyabean varieties cultivated in different soil
      climatic zones under various weather conditions was examined. Changes in the
      biochemical parameters were primarily associated with the genotype of the
      variety. The effect of weather, soil and climatic conditions was less marked.
      With an increase of the protein content the concentration of lysine and
      methionine in proteins tended to decrease. As long as the oil content in seeds
      grew, the concentration of oleic acid increased and that of linoleic and
      linolenic acids decreased.

PMID- 1034302
TI  - [Chemotherapy of urogenital system tuberculosis].

PMID- 1034303
TI  - Poor intrauterine growth and juvenile hypothyroidism.

PMID- 1034304
TI  - Chronic intermittent ethyl alcohol inhalation and avoidance learning.
AB  - Weanling male and female rats were chronically exposed to alcohol for 50 days
      using an intermittent inhalation technique which does not cause alcohol
      dependency. After 17 days of no exposure to alcohol, animals began two-way active
      avoidance testing. Results indicated that males were impaired on this task and
      females were not while at the same time males had reduced body weights. The male
      weight reduction was not responsible for the avoidance impairment. It was
      concluded that impaired avoidance learning following chronic esposure to alcohol
      is not specific to dependency models of animal alcoholism.

PMID- 1034305
TI  - Effects of lesions of the caudate nucleus on morphine dependence in the rat.
AB  - Naloxone-precipitated withdrawal and oral self-administration of morphine were
      compared in norphine-dependent caudate-lesioned and sham animals. The lesion
      failed to suppress any signs of withdrawal in the dependent-lesioned animals as
      compared with the shams. However, the dependent-lesioned animals self
      administered less morphine that their sham controls. The withdrawal results
      differed from others previously reported and it was hypothesized that the
      possibility of development of processes compensatory to the lesion among animals
      of this experiment, might account for the difference. The results were also
      discussed in relation to possible dissociation of mechanisms governing physical
      dependence and self-administration.

PMID- 1034306
TI  - Microbiological transformations of steroids. III. Transformation of progesterone
      to androstadienedione by the mycelia and by non-germinating spores of two fungi.

PMID- 1034307
TI  - Flavonoids of some species of Sedum.

PMID- 1034308
TI  - Indirect effects of footshock stress and coping on alcohol consumption of food
      deprived and non-deprived rats.

PMID- 1034309
TI  - Daily self-reports on activities, life events, moods, and somatic changes during
      the menstrual cycle.
AB  - Thirty-three undergraduate students (11 males, 11 females taking oral
      contraceptives, and 11 females not taking oral contraceptives) filled out daily
      self-reports on pleasant activities, stressful events, moods, and somatic changes
      for 35 consecutive days. By randomly assigning each male a "pseudo" cycle, the
      data were analyzed to compare the three samples across the three phases of the
      menstrual cycle. The results indicated that males reported somewhat more stable
      but less positive experiences than females. While males reported a stable, low
      level of pain and water retention throughout the study, both female samples
      reported increases during the premenstrual and menstrual phases. Reports of
      negative affect, impaired concentration, and stressful events did not differ by
      samples, but significant sample by cycle interactions reflected differential
      increases in the two female samples during the premenstrual and menstrual phases.
      Subsequent analyses indicated that the experience of stressful events accounted
      for more of the variance than did cycle phase for these negative mood factors,
      but not for pain and water retention.

PMID- 1034310
TI  - Pulmonary radiation reaction in the treatment of carcinoma of the breast.
AB  - Chest roentgenograms were performed regularly before and a long time after
      radiotherapy in 157 patients with cancer of the breast. Radiation-induced
      parenchymal changes were demonstrated in 73 per cent of the patients and pleural
      effusions in about 10 percent. Total regression of the parenchymal changes were
      extremely rare, but a slight decrease in the volume of the affected lung was
      normal. The radiation-induced pleural effusion had no special characteristics,
      but, with one exception, it occurred simultaneously with radiation-induced
      parenchymal infiltrates, and it did not increase in quantity in any case.

PMID- 1034312
TI  - [On prophage induction and DNA metabolism (author's transl)].

PMID- 1034311
TI  - Evaluation of the proper photographic density range of Lodose mammography.
AB  - An underexposed or overexposed mammogram can make it impossible for the
      radiologist to arrive at the proper diagnosis and may cause unnecessary radiation
      exposure to the patient. The range of photographic densities that can result in
      properly exposed, underexposed, or overexposed mammograms when the Lodose system
      is used has been determined. This study should be of significant value to
      technologists who do mammography on a routine basis and to those involved in mass
      screening programs.

PMID- 1034313
TI  - Effect of prostaglandins on 3H-thymidine uptake into human epidermal cells in
      vitro.
AB  - Prostaglandins A2, B1, E1, E2, F1alpha and F2alpha were added to cultures of
      human epidermal cells (keratinocytes) for 24 hours at 37 degrees C, and the
      effects on 3H-thymidine uptake into DNA was measured. At 70 mu/ml all
      prostaglandins tested except PGF2alpha inhibited the uptake of 3-thymidine
      greater than 50%. However, at 35 mug/ml, PGA2 and PGB1 were the only two
      prostaglandins to show significant inhibition, 96% and 51% respectively. At 17.5
      mug/ml only PGA2 caused substantial inhibition, 68%. In order to determine if the
      PGA2 action was mediated by membrane receptors propranolol, phentolamine,
      metiamide and prostynoic acid were added in conjunction with PGA2. None of the
      above receptor antagonists were able to reduce the PGA2-induced inhibition of 3H
      thymidine uptake. These results indicate that the pre-incubation of human
      keratinocytes  with prostaglandins for 24 hours results in a decrease of 3H
      thymidine incorporation in DNA. The precise mechanism of action is unknown at
      this time.

PMID- 1034314
TI  - [Value of chorionic gonadotropin (HCG) determination in diagnosis and treatment
      of choriomic epithelioma (author's transl)].

PMID- 1034315
TI  - [Concept of risk in perinatology: the obstetrician point of view (author's
      transl)].
AB  - Perinatal risks involve the life and health of the mother and baby. It is
      possible to define both medical and socio-cultural risk factors. They are
      frequently associated. The surveillance of pregnancy is modulated by the
      clinician according to his preception of these factors. One essential medical
      problem is to define the field of application of some examination or therapeutic
      procedures: to all patients or to selected groups according to clinical criteria.
      There is no general rule. Some types of surveillance such as serodiagnosis of
      rubella or toxoplasmosis, or the electronic monitoring of labour involve all
      women. At the opposite, progestative treatment must be given only to patients at
      high risk of premature labour. From the public health point of view, it doesn't
      seem realistic to implement different policies according to risk. Surveillance
      and perinatal care must apply to all pregnant women. This policy, however, must
      take into account a fondamental finding of recent surveys, i.e. the deficiency of
      prenatal surveillance among the most exposed socio-cultural categories and
      regions, in order to improve information about the rights and duties of the
      pregnant woman, the concept of risk and how it can be reduced. The role of
      epidemiological surveys in defining risk factors appears fundamental.
      Coordination among studies would be desirable. In the future they will probably
      aid the clinician in real time diagnosis and decision.

PMID- 1034316
TI  - Control of ethanol withdrawal symptoms in mice by phenytoin.
AB  - Mice were made physically dependent upon ethanol using either of two methods
      which involved ethanol vapor inhalation. Following the cessation of exposure to
      ethanol, the severity of handling-induced convulsions and changes in the response
      to an electric foot shock (startle reflex) were recorded. Animals given isotonic
      saline or propylene glycol:ethanol vehicle during withdrawal exhibited handling
      induced convulsions, and ethanol (2.0-4.0 g/kg) or phenytoin (5-20 mg/kg)
      administration during withdrawal resulted in a reduction in the severity of these
      convulsions. A reduced startle reflex threshold was also evident during
      withdrawal in mice given isotonic saline or propylene glycol:ethanol vehicle.
      Ethanol (0.5-4.0 g/kg) or phenytoin (10-20 mg/kg) administration during
      withdrawal resulted in a significant elevation of the startle reflex threshold
      compared to control animals. The results are discussed as they relate to others
      obtained in experimental and clinical studies.

PMID- 1034317
TI  - [Effect of truncal vagotomy on the occurence of gastric mucosal lesions induced
      by hemorrhagic shock in piglets (author's transl)].
AB  - 3 groups of total 37 mini-pigs have been bled to a mean aortic blood pressure of
      40 mm Hg for three hours (Norton et al., 1972): Group I: hemorrhagic shock along
      (n = 15) Group II: right thoracotomy prior to shock without vagotomy (n = 4)
      Group III: right thoracotomy prior to shock with truncal vagotomy right above
      diaphragm (n = 15) 3 animals died during shock. All others showed severe mucosal
      hyperaemia and hemorrhage after shock, which intensified in animals without
      vagotomy during 8-24 hours. Gastric mucosal lesions of vagotomized animals did
      not differ to those of group I and II, when the animals were killed 4-8 hours
      after shock. However, there was a significant reduction of early changes after 12
      24 hours, when compared to groups I and II. This study shows, that truncal
      vagotomy has no effect on the occurence of gastric mucosal lesions, which are
      induced by hemorrhagic shock in piglets, but prevents these from developing into
      severe bleeding peptic ulceration.

PMID- 1034318
TI  - [Relationship between circulation and respiration in shock].

PMID- 1034319
TI  - [Pulmonary veno-occlusive disease (author's transl)].

PMID- 1034320
TI  - [Dopamine-beta-hydroxylase (DBH)].

PMID- 1034321
TI  - [Modeling and simulation of contractile process of heart muscle (author's
      transl)].

PMID- 1034322
TI  - [Cardiogenic shock. III. Etiological consideration on postoperative low-output
      syndrome].

PMID- 1034323
TI  - [Analysis of left ventricular function with the aid of computer (author's
      transl)].

PMID- 1034324
TI  - [Management of acute myocardial infarct].

PMID- 1034325
TI  - [Evaluation of systolic time intervals. (1) Determination of the left ventricular
      systolic time intervals].

PMID- 1034326
TI  - [Pulmonary thromboembolism in a sequent autopsy series of 200 elderies (author's
      transl)].

PMID- 1034327
TI  - [The acid-base balance in hypothermia--in vivo CO2 titration curves in dogs under
      simple deep hypothermia (author's transl)].

PMID- 1034328
TI  - [Supernormal excitation due to elevation of ventricular stimulation threshold-
      report of a case (author's transl)].

PMID- 1034329
TI  - [Blood gas and respiration. The role of the respiratory control system in blood
      gas homeostasis].

PMID- 1034330
TI  - [In Brazil the onchocerciasis was discovered in 1875].

PMID- 1034331
TI  - [Esfar in an ENT department].

PMID- 1034333
TI  - Limbic electrical activity alterations during experimental neurosis in adult
      cats.

PMID- 1034332
TI  - [Exchange transfusion].

PMID- 1034334
TI  - Aplastic anaemia with 'hot pockets'.
AB  - 4 patients with chronic severe aplastic anaemia and with persistent foci of
      intense haematopoietic activity, so-called 'Hot Pockets', in their bone marrow
      were studied. In all patients the remainder of the bone marrow was
      morphologically and erythrokinetically hypoplastic. The cellular morphology in
      these 'Hot Pockets' displayed megaloblastic features and definite maturation
      abnormalities in erythroblasts, but no consistent changes in the myeloid or
      megakaryocytic series. The presence of persistent 'Hot Pockets' presents a
      conceptual challenge since these pockets contain multipotential stem cells
      capable of differentiation and self-renewal, but obviously incapable of
      repopulation of the bone marrow. In view of additional evidence for
      dyserythropoiesis in aplastic anaemia such as changes in erythroblast morphology
      and the production of macrocytes, fetal haemoglobin and complement sensitive
      cells, it seems likely that the bone marrow of aplastic anaemia patients is
      totally dyserythropoietic rather than hypoactive and that bone marrow
      transplantation in many cases may be both justified and necessary.

PMID- 1034335
TI  - Electrophysiological techniques for the study of urethral and vesical
      innervation.
AB  - A new electrophysiological technique for the study of urethral and vesical
      innervation is reported. The method gives valuable information on the structural
      integrity and function of two of the reflex arcs involved in micturition. Normal
      and pathological patterns are described, illustrating the diagnostic value of the
      method in the assessment of neurogenic disturbances of bladder and urethral
      function.

PMID- 1034336
TI  - A critical review of recent adoption, twin, and family studies of schizophrenia:
      behavioral genetics perspectives.

PMID- 1034337
TI  - Commentary on "a critical review of recent adoption, twin, and family studies of
      schizophrenia: behavioral genetics perspectives".

PMID- 1034338
TI  - Twins--still our best method.

PMID- 1034339
TI  - Progress in research on the genetics of schizophrenia.

PMID- 1034340
TI  - [Transitory remission of hypercorticism by means of cyproheptadine in a patient
      with Cushing syndrome].
AB  - In patients with Cushing's syndrome of hypothalamischem Cushing-Syndrom wereden
      eine zentrale Storung und eine wichtige Rolle des Serotonins.  Accordingly, in
      the present study a patient with hypothalamic-pituitary hypercorticism was
      treated with the seotonin antagonist cyproheptadine. Urinary free cortisol
      excretion was measured repeatedly before, during and after therapy. In addition,
      night-day rhythm of plasma cortisol was determined before and at the end of
      cyproheptadine medication. Within 2 months, therapy with 24 mg cyproheptadine
      resulted in a lowering of urinary cortisol excretion to normal values. Then,
      however, despite continuation of the therapy, urinary free cortisol excretion
      rates again rose to pathological levels. Due to the occurrence of severe
      psychosis, the drug had to be withdrawn. Before and under cyproheptadine no night
      day rhythm of plasma cortisol could be observed.

PMID- 1034341
TI  - [Anti-thrombocyte antibodies].
AB  - 1. There are two possible ways in which platelets may be involved in immune
      reactions: a) as target cells for antiplatelet antibodies, and b) as receptor
      cells for circulating antigen-antibody complexes. Since most of the clinical
      tests used to detect "antiplatelet antibodies" are incapable of discriminating
      between the two mechanisms, thrombocytopenia in many autoimmune diseases with
      "antiplatelet antibodies" may well be caused by immune complexes. 2. Immune
      reactions involving platelets do not always lead to thrombocytopenia. A moderate
      acceleration of platelet destruction can easily be compensated by increased
      production: this situation corresponds to a "compensated thrombocytolytic state".
      Evidence is also presented for immunologically induced functional platelet
      defects of "immunologic thrombocytopathy.

PMID- 1034342
TI  - [Lymphocyte antigens in autoimmune thrombocytopenia].
AB  - 18 patients with proven autoimmune thrombocytopenic purpura (ATP) (group A) were
      screened for human lymphocyte antigens (HLA) and compared with 13 patients with
      secondary thrombocytopenic purpura (group B). An additional comparison was made
      with a control panel of a European population (group C). HLA-B8 was present in 12
      of 18 patients (66.6%) of group A, compared with only one of 13 patients (7.6%)
      of group B. HLA-B12 occured in 8 of 18 patients (44.4%) of group A, compared
      with, again, only one of 13 patients in group B. The alleles HLA-B8/B12 were
      observed in 7 of 18 patients (38.8%) of group A, whereas no patient of group B
      exhibited such phenotypes. The differences were statistically significant (p less
      than 0.001 to p less than 0.03). A high incidence of the antigens HLA-B8/B12 has
      been noted in a family of which three members displayed serious symptoms of ATP
      over three generations. Thus, it is conceivable that individuals who carry the
      HLA-B8/B12 alleles run an increased risk of developing the disease if they are
      exposed to additional causal factors which finally trigger ATP.

PMID- 1034343
TI  - [Hemorrhagic-purulent, necrotizing meningo-encephalitis in the donkey; a cerebral
      nematode disease?].

PMID- 1034344
TI  - [The effect of surgery of the teats on the health of the udder].

PMID- 1034345
TI  - [Thrombocytopenic purpura in suckling pigs from 3 litters of the same parent
      animals].

PMID- 1034346
TI  - Interviewing in Goa: methodological issues in the study of a bilingual culture.

PMID- 1034347
TI  - Professions and social background: the work organisation of general
      practitioners.

PMID- 1034348
TI  - [Perspectives of the use of gas continuous-action lasers in oncology].

PMID- 1034349
TI  - [Hereditary hemorrhagic thrombocytoasthenia].

PMID- 1034350
TI  - [The problem of contraception in adolescence].

PMID- 1034351
TI  - [The embryotoxic and antimitotic properties of a series of benzimidazoles].

PMID- 1034352
TI  - [Studies on mastitis in ten groups of female offspring (author's transl)].
AB  - The incidence of mastitis in groups of female offspring of ten AI bulls was
      studied under field conditions. Marked variations in the incidence of symptoms of
      mastitis were observed. The results of this preliminary study were verified
      experimentally. Efforts should be made to direct breeding policies towards the
      selection of animals resistant to mastitis. The possibilities of selective
      breeding have been considerably improved by adopting modern methods of recording.

PMID- 1034353
TI  - [Causes of elimination and death in sows].

PMID- 1034354
TI  - [Innovar-vet for neuroleptoanalgesia in rabbits and guinea pigs].

PMID- 1034355
TI  - Geographic distribution of premature nurseries in the United States.

PMID- 1034356
TI  - A simple radioimmunoassay for plasma cortisol and 11-deoxycortisol (17, 21
      dihydroxy-4-pregnene-3, 20-dione).
AB  - A simple procedure for the measurement of cortisol and 11-deoxycortisol in plasma
      or serum is described. One-half ml. of plasma is extracted with methylene
      chloride. Separation of cortisol and deoxycortisol is achieved by a Sephadex LH
      20 mini-column. The assay itself is achieved by the use of a commercially
      available cortisol kit employing rabbit anti-cortisol coated tubes. This antibody
      exhibits a 20% crossreactivity with 11-deoxycortisol. This procedure is extremely
      useful in the assessment of a pituitary-adrenal reserve in the Metyrapone test.

PMID- 1034357
TI  - Quantitative changes in the metabolism of 20alpha-hydroxy-4-pregnen-3-one by rat
      hypothalamus and pituitary during proestrus.
AB  - The in vitro conversion of 20alpha-hydroxy-4-pregnen-3-one (20alpha-DHP) by
      medial basal hypothalamus and anterior pituitary was investigated throughout the
      day of proestrus in the 4-day cyclic rat. Reverse isotopic dilution analysis was
      utilized to quantitate the substrate remaining and three metabolic products:
      20alpha-hydroxy-5alpha-pregnan-3-one, 5alpha-pregnane-3alpha,20alpha-diol and
      progesterone. Serum levels of 20alpha-DHP, progesterone, LH and FSH were measured
      by radioimmunoassay. Conversion of 20alpha-DHP to its 5alpha-reduced metabolites
      (20alpha-hydroxy-5alpha-pregnan-3-one and 5alpha-pregnane-3alpha,20alpha-diol) by
      the pituitary was constant throughout proestrus except for a significant decrease
      at 1600 h, near the end of the critical period. Although 5alpha-reduction of
      20alpha-DHP by the hypothalamus fluctuated, it was relatively high at 1600 h and
      was lowest at 1400 h. Small amounts of progesterone (less than2%) were formed but
      there was not variation with time. The decrease in pituitary enzymic activity
      coincided with the time when serum levels of LH, FSH and progesterone were
      increasing but not with later times when the elevated serum levels were
      maintained. Thus, there may be endogenous regulation of 5alpha-reductase and
      3alpha-hydroxysteroid dehydrogenase activity in rat pituitary and perhaps
      hypothalamus on the afternoon of proestrus. The regulation and subsequent effects
      of quantitative changes in 5alpha-reduction of 20alpha-DHP by pituitary and
      hypothalamus remain to be elucidated.

PMID- 1034358
TI  - Stimulation of hamster and human lymphocyte cultures by soluble egg antigens
      (SEA) of Schistosoma haematobium and S. mansoni.
AB  - Soluble egg and adult worm antigen preparations of Schistosoma haematobium and S.
      mansoni were tested in hamster and human lymphocyte cultures. Primed lymphocytes
      from infected donors showed a marked blastogenic response to the homologous
      antigens. A cross-reactivity to the heterologous antigens was seen especially in
      S. mansoni infected hamsters.

PMID- 1034359
TI  - Closed-circuit television magnification of fluorescein angiography.

PMID- 1034360
TI  - Nd:Yag laser.

PMID- 1034361
TI  - [Fluorescence angiography in laser therapy of retinal vein thrombosis].

PMID- 1034362
TI  - [Laser coagulation of semitransparent retroprosthetic films, secondary lamellar
      cataract and posterior synechiae].

PMID- 1034363
TI  - Transmission of vaccinia virus from vaccinated milkers to cattle.
AB  - An infection of cattle by transmission of vaccinia virus from milkers vaccinated
      against small pox is reported. Six vaccinia virus strains could be isolated from
      the vaccinal lesions localized on the nipples of the udder. Serological reactions
      with samples collected from diseased cows demonstrated the presence of HAI
      antibodies and made evident their kinetics at a 2-week-interval.

PMID- 1034364
TI  - Flying clouds: an illusion of visual capture and distance reversal.

PMID- 1034365
TI  - [Electrocardiographic changes following gastroscopy].

PMID- 1034366
TI  - [Practical use of cardiac glycosides].

PMID- 1034367
TI  - [Decrease in the excretion of antigonadotropic factor in patients with cancer of
      the uterine cervix and prostate gland. Experimental antitumor effect of an
      epiphyseal extract].
AB  - Kaolin-acetone extracts from the urine of patients with cancer of the prostatic
      gland and uterine neck were found to contain much less quantity of
      antigonadotropic factor than corresponding substances from the urine of control
      groups of males and females. This evidences a decreased function of the epiphysis
      in these groups of tumor patients. Acetic acid extract from cattle epiphyses
      inhibits the growth of transplantable tumor of mice strain RSM.

PMID- 1034368
TI  - [Kinetic patterns in the growth of transplantable mouse tumor RShM-1].
AB  - Under study was the kinetics of growth of cervical cancer (CCM-1) transplanted on
      mice CBA, also the mitotic cycle and diurnal activity of tumor cells division.
      The tumor growth can well be described with the Hompertz equation, the constants
      of acceleration and retardation being equal to 0.34 day-1 and 0.004 day-1
      accordingly. A linear dependence between the size, weight and number of CCM-1
      celos is shown. In the tumor under study a persistant diurnal rhythm of the cell
      division was found with the maximum at 7 and 19 hours and the minimum at 13. The
      basis parameters of the mitotic cycle of tumor cells were determined: Tc=17.8
      hr., G2 approximately 40 min.; S=9 hr., M approximately 24 min., G1 approximately
      18.4 hr. The time of tumor doubling was 48.7 hr. The cell loss factor is as much
      as 42.1 per cent.

PMID- 1034369
TI  - [Proliferation of a culture of rat fibroblasts chronically infected with
      oncogenic A-12 virus].

PMID- 1034370
TI  - [Biochemical changes in patients poisoned with Agaricus bulbosus].

PMID- 1034371
TI  - [Oncornavirus D--an inducer of a new antigen].
AB  - Oncornavirus D inoculated into chick fibroblast cultures induced in them
      synthesis of a new antigen which is not incorporated into the virion structure
      and is absent in cells not infected with this virus. The oncornavirus D newly
      induced antigen is identical to that found in long-term continuous human HeLa,
      HEp-2 and J-96 cells. These facts give grounds to believe that the new antigen
      present in these cells emerged as a consequence of their infection with
      oncornavirus D. However it remains unknown whether this antigen plays the role of
      the transforming agent and whether transformation of normal human cells into
      malignant cells is associated with it.

PMID- 1034372
TI  - [Determination of the biosynthetic chemotherapeutic index of antiviral agents in
      cell culture].
AB  - An experimental substantiation of an improved approach to testing antiviral
      chemotherapeutic agents in tissue culture was done on the model of Venezuelan
      equine encephalomyelitis virus and primarily trypsinized chick embryo fibroblasts
      using some biologically active agents such as actinomycin D, RNA-ase, gentamycin,
      poly (rI). poly (rC). The approach is based on combined use of stationary
      cultivation of cells and virlses, a method for determination of radioactivity of
      the cells grown directly in vials for scintillation counting as well as methods
      for determination of virus-specific and cell syntheses by incorporation of
      labeled precursors. The features of the mechanism of action of the agents under
      study is discussed in terms of their influence on cell metabolism.

PMID- 1034373
TI  - [Comparative data on the propagation of cells from commercial common and leukemia
      free chick embryos].
AB  - Certain differences were found in comparative studies of optimal conditions for
      preparation and propagation of cell cultures from common and leukemia-free chick
      embryos. The yield of cells per 1 g of tissue was regularly higher by 12-20% with
      leukemia-free chick embryos than with common chick embryos. The viability of the
      latter under conditions of roller cultivation was lower. Monolayer cultures of
      cells from leukemia-free chick embryos formed 1 day earlier than those from cells
      of common chick embryos. The optimal medium for growth of leukemia-free chick
      embryo cells was 0.5% lactalbumin hydrolysate, and for common chick embryo cells-
      Eagle's medium.

PMID- 1034374
TI  - [Comparative study of antigens specific for hepatitis B in transfected cell
      cultures].
AB  - A comparative study of antigens detected in the livers of patients with hepatitis
      B. in the mesonephros of the human tissue--chick embryo system infected with the
      agents isolated from the blood of hepatitis patients, as well as antigens
      detectable in cell cultures transfected by the DNA isolated from these tissues
      was carried out. The results are in favour of the hypothesis on the integrational
      nature of serum hepatitis.

PMID- 1034375
TI  - [Anastomosis of the vas deferens employing concentrated fibrinogen: an
      experimental study in rabbits (authors transl)].
AB  - Bilateral vaso-vasostomy was carried out in 30 rabbits using highly concentrated
      fibrinogen in combination with thrombin and clotting Factor XIII for tissue
      adhesion. The patency of the anastomoses was confirmed radiologically and by the
      injection of a dye, as well as histologically in paraffin-embedded and Goldner
      stained serial sections. The overall patency amounted to 58% in animals
      investigated 4--6 weeks postoperatively (i.e. 17 out of 30 anastomoses). Stenosis
      of the junction was observed in all patent anastomoses investigated. The results
      of vaso-vasostomy employing a biological tissue adhesive were markedly superior
      to those with cyanoacylate.

PMID- 1034376
TI  - Effects of polyamines and analogs on staphylococcal nuclease.
AB  - The promoting activity of polyamine analogs (IV approximately XV) on
      staphylococcal nuclease with DNA as the substrate was compared with that of
      natural polyamines (I APPROXIMATELY III): I.
      NH2(CH2)3NH(CH2)4NH(CH2)3NH2(spermine); II.
      NH2(CH2)3NH(CH2)3NH(CH2)3NH2(thermine); III. NH2(CH2)4NH2 (putrescine); IV.
      CN(CH2)2NH(CH2)4NH(CH2)2CN; V. HOOC(CH2)2NH(CH2)4NH(CH2)2COOH; VI.
      C2H5OOC(CH2)2NH(CH2)4NH(CH2)2COOC2H5; VII. HO(CH2)3NH(CH2)4HH(CH2)3OH; VIII.
      CH3COHH(CH2)3NH(CH2)4NH(CH2)3NHCOCH3; IX. C2H5NH(CH2)3NH(CH2)4NH(CH2)3NHC2H5; X.
      NH2(CH2)3S(CH2)4S(CH2)3NH2; XI. NH2(CH2)3NH(CH2)2O(CH2)2NH(CH2)3NH2; XII.
      NH2(CH2)3NCH3(CH2)4HCH3(CH2)3NH2; XIII. CN(CH2)2NCH3(CH2)4NCH3(CH2)2CN; XIV.
      (CH3)2N(CH2)3NCH3(CH2)4NCH3(CH2)3N(CH3)2; XV. NH2(CH2)2O(CH2)2NH2 Replacement of
      the terminal groups by CN, COOH, COOEt, NHAc, NHEt, or N(CH3)2 remarkably
      decreased the activity. The compound VII with terminal hydroxyl groups had a
      lower promoting activity at low concentrations, but revealed higher activity at
      higher concentrations and, in contrast to spermine, no inhibition at all even at
      very high concentrations. Replacement of both internal amino groups by sulfur or
      NCH3 decreased the activity. The introduction of an ether bond into the internal
      methylene groups (compound XI) highly decreased the activity. Based upon these
      findings the possible relationship between structure and activity is discussed.

PMID- 1034377
TI  - [Tasks and importance of operative andrology].

PMID- 1034378
TI  - Different glycosubstances and galactans in the albumin gland and eggs of Achatina
      fulica.
AB  - In saline extracts from the eggs and the albumin gland of the snail Achatina
      fulica 3 different forms of glycosubstances have been found by using heterophile
      precipitins from different sources: 1. An alkali-stable galactan reacting with
      the anti-galactans from Axinella polypoides sponge and from the clam Tridacna
      maxima (Tridacnin) and with Concanavalin A. 2. Another glycosubstance giving
      cross-reactions with a second precipitin from Axinella polypoides, with the
      lectin from Ricinus communis, with murine myeloma anti-galactan, with
      pneumococcus Type XIV antiserum and with Tridacnin. 3. The second precipitin from
      Axinella polypoides detects a third glycosubstance, which reacts with the lectins
      from Abrus precatorius and wheat germ (Triticum vulgaris).

PMID- 1034379
TI  - [Sport for therapy and rehabilitation--especially riding therapy].

PMID- 1034380
TI  - [Hemoperitoneum in angioblastic sarcoma of the small intestine. Report of a case
      with a 5-year healing period].

PMID- 1034381
TI  - [Studies of the detection of soybean protein in meat products detection of
      canavanine (author's transl)].

PMID- 1034382
TI  - [Studies of the detection of soybean protein in meat products isolation of a
      characteristic protein zone (author's transl)].

PMID- 1034383
TI  - The effect of antioxidants on the production of volatile nitrosamines during the
      frying of bacon.
AB  - In model system studies simulating the frying of bacon a considerable variation
      in the production of N-nitrosopyrrolidine (NOPyr) has been observed, as occurs in
      sliced bacon fried conventionally. The inclusion of ascorbate or erythorbate
      (isoacorbate) has led consistently to a fall in or an elimination of NOPyr
      production up to an addition of 300 ppm (1,5 mM). Above this concentration of
      ascorbate, the elimination of NOPyr formation persisted in some instances but in
      others an increased production of the nitrosamine occurred. Using alpha
      tocopherol, a fall of NOPyr production during the simulated frying of bacon was
      obtained with increase of concentration of the antioxidant, there being a
      consistent elimination of the volatile nitrosamine following an additionof 500
      ppm (1.16 mM). Whilst ascorbyl palmitate had a similar action in reducing or
      eliminating NOPyr production, no synergistic effect between it and alpha
      tocopherol was noted in an experiment combining the two antioxidants. When bacon
      was fried in fat containing 400 or 800 ppm alpha-tocopherol, the total production
      of NOPyr and DMN in the fried bacon, cooked out fat and condensate was markedly
      reduced but not completely eliminated as in the model system studies. Similarly,
      the curing of bacon with a brine containing a mixture of alpha-tocopherol,
      ascorbyl palmitate and citric acid has led to considerable reductions in NOPyr
      and DMN output on frying when the combined concentrations of the two anti
      oxidants were calculated to be 800 ppm.

PMID- 1034384
TI  - Adaptation of calcium absorption from the small intestine of dairy cows to
      changes in the dietary calcium intake and at the onset of lactation.

PMID- 1034385
TI  - Some aspects of reproduction in fat-tailed sheep in subtropics. II. Seasonal
      variation in ovarian activity.

PMID- 1034386
TI  - [Manometry, effect of pentagastrin and appearance of reflux in experimentally
      created hiatal hernia (author's transl)].
AB  - The importance of morphological and hormonal factors in the gastro-oesophageal
      junction can be evaluated, since a hiatal hernia comparable to the axial sliding
      hernia could be created in animal experiments. A new adequate procedure of
      manometry enables intraluminal pressures to be measured as a functional analysis.
      In 10 dogs a hiatal hernia with roentgenological reflux was performed.
      Pentagastrin administered intravenously could not prevent the gastro-oesophageal
      reflux. Pentagastrin intensified the muscle tension for only 5 minutes, but could
      not maintain the closing mechanism because of the altered morphological
      structure. After having restored the longitudinal tension of the organ by
      gastropexia, the terminal oesophagus has regained its closing function.

PMID- 1034387
TI  - [Function of thrombocytes during the gestational period and puerperium and their
      relation to the occurence of thromboses. 2. Function of blood platelets during
      late pregnancy, labor and puerperium in gestosis].
AB  - Platelet functions during late pregnancy with praeeclampsia, birth and childbed
      were observed. There are found variations in opposition to normal pregnancy.
      Increase of platelet aggregation was clearest. In this observations is not
      conclud from increase risk developing a thromboembolic disease during toxemic
      pregnancy, birth and childbed. The variations of platelet functions are parts of
      complex appearence.

PMID- 1034388
TI  - [The effects of enzymes and secretions of the gastrointestinal tract on the EB
      vaccine strain].
AB  - Experiments were conducted in vitro. A study was made of the action of the
      enzymes and of the secretions of the gastrointestinal tract on the viability of
      the EB vaccine strain. Sensitivity of bacterial cells to the action of saliva,
      gastric juice, intestinal contents, trypsin, and bile proved to differ. Gastric
      juice inactivated the vaccine strain which expressed a satisfactory resistance
      towards the rest of the factors under study practically immediately. There were
      revealed no significant morphological changes in the cells subjected to the two
      hour action of saliva, bile, trypsin and the intestinal content, by means of the
      electron microscopic examination. These studies permitted to substantiate the
      rational form of the preparation for oral administration.

PMID- 1034389
TI  - [Rosette formation and humoral immune response to 2,4-dinitrophenol in mice of
      different inbred strains].
AB  - A study was made of the content of rosette-forming cells to DNP-ovalbumin in the
      spleen of mice of different inbred strains. The values of the rosette-forming
      cells and of the titre of serum agglutinins to the DNP-group in DNP--bovine gamma
      globulin immunization of mice of these strains were determined. It was shown that
      there were interstrain differences in respect to the normal and immune rosette
      forming cells and also humoral antibodies. There was noted a direct correlation
      between the number of the immune rosette-forming cells and the antibody titre in
      the serum of mice of the same inbred strain. Immune response (both by the content
      of rosettes in the spleen and by the antibody level) proved to be the minimal in
      mice with the highest level of rosette-forming cells. There proved to be no
      inverse relationship.

PMID- 1034390
TI  - [Effects of electric stimulation on the tissue respiration - with special
      reference to oxygen consumption and movement of cations].

PMID- 1034391
TI  - Glaucine: development of tolerance and morphine-like physical dependence in
      animals.

PMID- 1034392
TI  - The cerebral GABA, beta-alanine, lysine and ethanolamine content and conversion
      of 14C from U 14C D glucose into their molecule during emotional stress in rats;
      effect of pyrithioxin and diazepam pretreatment.

PMID- 1034393
TI  - The effect of alcohol administration during pregnancy on concentration of
      noradrenaline, dopamine and 5-hydroxytryptamine in the brain of offspring of mice
      [proceedings].

PMID- 1034394
TI  - Anthropology of the inhabitants of Uttar Pradesh in India.

PMID- 1034395
TI  - [Morphological study on the navicular bone and insertion of tibialis posterior
      muscle in human foot. (Os naviculare pedis and os tibiale externum. 2)].

PMID- 1034396
TI  - [Immune adhesion during experimental Erysipelothrix infection].

PMID- 1034397
TI  - [Hemostasis disorders in the alcoholic].

PMID- 1034398
TI  - [The alcoholic terrain. Risks of management and surgery in the alcoholic].

PMID- 1034399
TI  - [Studies on cyclophoria and cyclotropia with the Aulhorn Phase Difference
      Haploscope (author's transl)].

PMID- 1034400
TI  - [Abnormal ocular movement in hemicerebral lesions in different neurological
      levels (author's transl)].

PMID- 1034401
TI  - [Spectral sensitivity of the human and rabbit ERG in vitro (author's transl)].

PMID- 1034402
TI  - [Lambda wave in the visual evoked responses (VER)-a releationship between the
      latency and speed of target (author's transl)].

PMID- 1034403
TI  - [Electrophysiological studies on the fellow eyes (so-called healthy eyes) of the
      patients with idiopathic detached retina. I. Findings of the average 30 Hz
      flicker ERG and the monochromatic flash ERG (author's transl)].

PMID- 1034404
TI  - [Cycloscopy and fluorescein cycloscopy. 2. Fundamental study of fluorescein
      cycloscopy (author's transl)].

PMID- 1034405
TI  - [Sympathetic and parasympathetic innervation of the ciliary body and trabecular
      meshwork of the cat: Fluorescence histochemistry and electron microscopy
      (author's transl)].

PMID- 1034406
TI  - [Roentgen diagnosis of the ophthalmological field by ACTA scanner (author's
      transl)].

PMID- 1034407
TI  - [Computerized tomography with A-scan echography in detection of orbital disorders
      (preliminary report) (author's transl)].

PMID- 1034408
TI  - [Quantitative histo-pathological study of the canine optic nerve treated by an
      organophosphate pesticide (author's transl)].

PMID- 1034409
TI  - [A high quality ultrasonic apparatous for the ophthalmological diagnosis using
      manual compound scanning (author's transl)].

PMID- 1034410
TI  - [The studies on the ultrasonic diagnosis in ophthalmology. (Report 11) Ten-year
      study on clinical ophthalmic echography. Part I. Echographic results in the
      differential diagnosis and diagnostic criteria (author's transl)].

PMID- 1034411
TI  - [Studies on intraocular injection of Dibekacin--toxic effects, clearance and
      experimental therapy of Pseudomonas endophthalmitis-(author's transl)].

PMID- 1034412
TI  - [Studies on visual substitution (author's transl)].

PMID- 1034413
TI  - [Clinical study on the refractive anomalies --remarks on making spectacles--
      (author's transl)].

PMID- 1034414
TI  - [Localization of a barrier between the optic nerve and retina (author's transl)].

PMID- 1034415
TI  - [Origin of newly formed vessels from the optic disc (author's transl)].

PMID- 1034416
TI  - [The ophthalmic circulation in occlusion of the internal carotid artery (author's
      transl)].

PMID- 1034417
TI  - [The influence of cervical autonomic nerve stimulation on ocular blood
      circulation (author's transl)].

PMID- 1034418
TI  - [Supersonic observation of eyes in premature babies. Part I. Hemodynamics at eye
      ground (author's transl)].

PMID- 1034419
TI  - [Fluorescein angiographic studies on retinopathy of prematurity (author's
      transl)].

PMID- 1034420
TI  - [The clinical significance of the width of the avascular area in the retinopathy
      of prematurity (author's transl)].

PMID- 1034421
TI  - [Experimental and clinical studies of prematurity and effects of oxygen
      administration on lipid peroxide in blood (author's transl)].

PMID- 1034422
TI  - [Effect of oxygen and photocoagulation on the developing retinal vessels of the
      rabbit (author's transl)].

PMID- 1034423
TI  - [Studies on the rabbit conjunctival cells in vitro (author's transl)].

PMID- 1034424
TI  - [Biochemical analysis of peripheral blood in patients with retinal pigmentary
      degeneration: abnormal value of lipo- and glycoprotein on electrophoresis
      (author's transl)].

PMID- 1034425
TI  - [Some observations on uveitis in Japan, with special reference to Vogt-Koyanagi
      Harada and Behcet diseases (author's transl)].

PMID- 1034426
TI  - [The macula and macular diseases (author's transl)].

PMID- 1034427
TI  - [Clinical aspect of diabetic retinopathy. Retinal microangiopathy in early
      diabetic stages including prediabetes (author's transl)].

PMID- 1034428
TI  - [The change in the macular region of the diabetic retinopathy and it management
      (author's transl)].

PMID- 1034429
TI  - [Clinical study of proliferative diabetic retinopathy (author's transl)].

PMID- 1034430
TI  - [Studies on aqueous outlets. Part II. Histopathological investigation on the
      influence of indocyanine green dye to the ocular tissues (author's transl)].

PMID- 1034431
TI  - [Tight and gap junction (author's transl)].

PMID- 1034432
TI  - [Results of trabeculotomy 'ab externo" --Mainly on open-angle glaucoma--
      (author's transl)].

PMID- 1034433
TI  - [Orbital exenteration (author's transl)].

PMID- 1034434
TI  - [Polarity of the oscillatory potentials recorded by a pair of electrodes on the
      sclera (author's transl)].

PMID- 1034435
TI  - [Electrophysiological study on glaucoma. Part I. Electroretinogram in primary
      glaucoma (author's transl)].

PMID- 1034436
TI  - [Endoscopic apparatus for vitreous surgery--application to treatment for vitreous
      haemorrhage--(author's transl)].

PMID- 1034437
TI  - [Observation on the diseases of the cornea and lens with the differential
      interference contrast microscope (author's transl)].

PMID- 1034438
TI  - [Electron histochemical demonstration of phosphorylase activity in the living
      rabbit cornea. Application of histochemical method to the living cornea (author's
      transl)].

PMID- 1034439
TI  - Dependence of Sertoli cell maturation on the pituitary gland in the mouse.
AB  - Postnatal development of the Sertoli cell population was studied in testes taken
      from newborn mice and implanted into the testes of normal hypophysectomized and
      testosterone-treated hypophyturation of the Seroti cell complement of each
      specimen was judged by two criteria: (1) the proportion of Sertoli cells
      exhibiting a nucleolonema; (2) the prevalence of specialized inter-Sertoli cell
      junctions. In these respects implants recovered from normal hosts did not differ
      from sibling controls of the same age. Sertoli cells in implants recovered from
      hypophysectomized hosts retained the features observed in newborn controls,
      indicating that maturation of the Sertoli cells is dependent on normal pituitary
      function. Implants recovered from testosterone-treated hypophysectomized hosts
      exhibited a degree of Sertoli cell development intermediate between those
      recovered from the other two host categories.

PMID- 1034440
TI  - Factors involved in immunization program for swine influenza.
AB  - The decision to undertake a nationwide program of vaccination against swine
      influenza requires assessment of the status of immunity of those in various age
      groups in our population against this agent. Pools of serum were collected from
      persons born in the years from 1889 to 1943; they were tested for hemaggultinin
      inhibiting (HI) antibody against the HSW 1N1 influenza virus strains isolated in
      1931 and 1976. The titers secured serve as an indication of the average level of
      immunity of those of different ages. Persons less than 43 years of age are found
      to be without antibody protection. The need for vaccination of people in
      different age groups based on mortality statistics of previous epidemics is
      evaluated. It is realized that no epidemic may occur and that a reduced virulence
      of the viral agent and use of antibiotics may reduce the death rate if the
      infection recurs. The extraordinary high mortality in 1918 in people between 15
      and 44 years of age deserves recognition together with the fact that those in the
      same age group are now without protection. The fact that women of childbearing
      age fall into this group deserves special consideration in view of increased
      mortality in puerperal women observed in the pandemics of 1918 and 1957. The
      degree of protection afforded the newborn by transplacental transmission of
      maternal antibodies is discussed. The need of increasing the level of immunity in
      those who have varying titers of HI antibodies is considered in relation to the
      prevalence of cardiopulmonary complications and other chronic diseases in older
      subjects.

PMID- 1034441
TI  - A sausage-associated outbreak of trichinosis in Illinois.
AB  - Twenty-three of 50 members of an extended Dutch-German family and their close
      friends who ate raw homemade summer sausage became ill with trichinosis; 12
      patients were hospitalized for an average of 10 days each. The sausage had been
      made in three different batches according to an old family recipe. One of the
      batches made from USDA-inspected pork was found to contain Trichinella spiralis
      larvae by two Illinois State laboratories. The other two batches were negative.
      Seventeen of the 23 patients submitted information on medical expenses incurred
      and wages lost because of the outbreak. These costs totaled almost $20,000. There
      is need for a nationwide program for controlling trichinosis in swine.

PMID- 1034442
TI  - Autochthonous dermal leishmaniasis in Texas.
AB  - Over a 2-year period two cases of dermal leishmaniasis of special interest were
      recognized in Texas. The first occurred in 1972 in a 74-year-old woman who had
      residences in Dilworth and Gahzales, Gonzales County, and the other was in a 56
      year-old man from Kenedy, Karnes County, in 1974. Both cases were biopsy- and
      culture-positive, and the second patient exhibited anti-Leishmania antibodies by
      indirect immunofluorescent antibody and direct agglutination tests. Epidemiologic
      investigation revealed no association between the two cases and suggested that
      both patients had acquired their infections locally in southern Texas. Moreover,
      serologic evidence of Leishmania infection was uncovered in a neighbor of the
      second case and in 3 dogs living nearby. Potential sylvatic reservoirs and
      arthropod vectors of the disease are resident in the area. Epidemiologic data
      suggest that dermal leishmaniasis is endemic in south-central Texas.

PMID- 1034443
TI  - Fine structure of schistosome eggs as seen through the scanning electron
      microscope.
AB  - Through a scanning electron microscope the eggs of Schistosoma japonicum were
      observed to have microvili-like chitinous projections densely distributed and
      entangled on the surface, each more than 3 mu in length and 0.05 to 0.08 mu in
      diameter. The microspines of eggs of S. mansoni and S. haematobium were found to
      be thicker, shorter, and less widespread than were those of S. japonicum eggs,
      and not entangled. It is noteworthy that such small projections on the surface of
      schistosome eggs remain erect in the critical point drying procedure.

PMID- 1034444
TI  - After smallpox eradication: yaws?
AB  - The WHO-coordinated Smallpox Eradication Program (SEP) has reduced the number of
      smallpox-endemic countries from 30 to 1, and now expects to complete the
      eradication of smallpox after a 10-year campaign. Campaigns to eradicate yaws
      were begun in the early 1950's with WHO and UNICEF support, and have greatly
      reduced the prevalence of that disease. Yaws has not yet been eradicated from any
      large geographic area, however, and is already resurgent in some countries. Some
      of the differences between the two diseases and available control measures are
      discussed. The thesis of this paper is that yaws programs have been deficient in
      failing to aggressively seek and contain yaws cases and contacts after mass
      treatment campaigns reduced yaws prevalence to low levels. It is further
      suggested that by using a modified SEP-type strategy to focus investigation and
      control efforts on infections yaws cases and their contacts, and by taking
      advantage of new methods to obtain more accurate diagnosis of yaws cases in the
      field, it should be possible to control yaws more effectively and efficiently,
      and perhaps to eradicate it. Outstanding barriers to yaws eradication are also
      discussed.

PMID- 1034445
TI  - [The bio-behavioral approach to preventive socio-psychiatry].

PMID- 1034446
TI  - [Puerperal infectious diseases].

PMID- 1034447
TI  - [Changes in cholinergic enzymes following surgical treatment of gynecologic
      patients using different methods of anesthesia].

PMID- 1034448
TI  - [Surgical treatment of ruptures of the uterine cervix with ectropion of the
      mucous membrane of the cervical canal].

PMID- 1034449
TI  - Erythropoiesis in the yolk sac of the bat Tadarida brasiliensis cynocephala.
AB  - The process of erythropoiesis and vasculogenesis in the yolk sac of the bat
      (Tadarida brasiliensis cynocephala) has been studied through the use of both
      light and electron microscopy. Stem cells arise from the leading edge of the
      migrating splanchnic mesoderm and transform into primitive erythroblasts.
      Differentiation involves either contact or association with the endodermal cells,
      since all erythropoietic activity occurs on the endodermal side of the expanding
      vascular bed, and many of the cells are in close apposition to the lateral or
      basal plasma membranes of the endodermal cells. Endodermal cells also phagocytize
      developing primitive erythroblasts during the later stage of the process when
      erythropoiesis is subsiding in the yolk sac. Cells destined to become the
      endothelium of the expanding vascular bed also arise from the leading edge of the
      migrating splanchnic mesoderm. Their process of differentiation involves the
      development of cytoplasmic extensions that may surround a group of
      differentiating erythroblasts, enclosing them in the newly formed lumen of the
      blood vessel. The cytoplasmic extensions make contact and develop junctional
      complexes with similar processes from other cells to complete the lumen of the
      lengthening vascular bed. Cells of the granulocyte series or megakaryocytes are
      not observed in the yolk sac of the bat as has been described in certain other
      species.

PMID- 1034450
TI  - Structural characterization and rapid manual isolation of a reptilian testicular
      tunic rich in Leydig cells.
AB  - During the annual breeding season, the testes of the lizard Cnemidophorus gularis
      are yellow-orange, oviod organs measuring almost 1 cm in greatest diameter. The
      pigment is confined to the testicular tunic, which contains a zone of Leydig
      cells and vascular channels more than 50 mu thick. Leydig cells constitute
      approximately 60% of the zone, with remaining space occupied by capillaries,
      sinusoids, and lymphatic vessels. Lymphatics are concentrated at the interface
      between tunic and seminiferous tubules. Interstitial space is poorly developed
      among the tubules, accounting for less than 3% of tissue volume. Capillaries,
      lymphatics, and few widely scattering Leydig cells occur in the sparse
      interstitial space. Leydig cells in the tunic and elsewhere in the testis show
      ultrastructural features commonly found in mammalian Leydig cells. Separation of
      the tunic from the seminiferous tubules is achieved in a few seconds by manual
      decapsulation of the testis and yields an enriched preparation of Leydig cells
      that is essentially uncontaminated by tubular elements.

PMID- 1034451
TI  - [Syngamus trachea of the titmouse].

PMID- 1034452
TI  - Bovine lymphocyte antigens: serological relationships with erythrocyte and
      spermatozoan antigens.
AB  - Bovine lymphocytotoxicity tests with 20 unabsorbed bovine blood group sera
      revealed extensive reactivity which in the majority of cases had no indication of
      blood group relationship. Six of these sera were absorbed with selected
      lymphocytes to produce eleven antisera of reduced specificity. Again, most of the
      sera had reaction patterns which could not be related to the hemolytic patterns
      of any known blood group antibodies. However, five comparisons involving
      unabsorbed antisera and two comparisons involving absorbed antisera provided
      statistical evidence of similarities between their lymphocytotoxic reaction
      patterns and the hemolytic reaction patterns of certain blood group antibodies.
      Several of the sera appeared to contain related cytotoxic specificities, and
      three such absorbed sera may have contained an anti-J specificity. All six
      examined monospecific isoimmune blood group antisera contained lymphocytic
      reactivities not related to their hemolytic specificities. Two normal sera
      containing naturally occurring anti-J had no cytotoxic activity. Anti-semen sera
      likewise were devoid of lymphocytotoxic activity.

PMID- 1034453
TI  - The temporal pattern of feeding over the oestrous cycle of the mouse.
AB  - The detailed temporal pattern of feeding in female mice was measured by an
      automated method over the oestrous cycle whilst feeding on either of two foods
      differing in stimulus characteristics, but of similar calorific value. The total
      time spent feeding varied systematically over the cycle, being increased for
      sweet food and decreased for laboratory chow at the time of sexual receptivity.
      and increased for both foods towards the end of the cycle. The temporal pattern
      is analysed into a number of variables, which are seen to alter in different ways
      over the oestrous cycle. The pro-oestrus disturbance is due to alterations in
      meal size brought about solely by changes in mean bout length, themselves
      products of variations in the initial bouts of the meal. Inter-meal interval is
      unrelated to changes in meal size at this time, allowing the latter to affect
      food intake. The changes towards the end of the cycle are produced by alterations
      of meal frequency at constant meal size. It is argued that separable 'phasic' and
      'tonic' effects of reproductive condition on feeding may therefore be identified,
      and that they might possibly have different functions.

PMID- 1034454
TI  - [Intraventricular glial tumor. in the evolution of Bourneville tuberous
      sclerosis: ultrastructural study].
AB  - Ultrastructural study of an intraventricular tumour in a child with Bourneville
      tuberose sclerosis showed the presence of marked glial astrocytic proliferation.
      All the tumour cells were undoubtedly of astrocytic type, as shown by the
      presence of gliofilaments and beta-type glycogenic particles. They were also
      characterized by an abundant ergastoplasm of an original type (lamellar stacking
      of the saccules), a well developed Golgi apparatus, a multitude of mitochondria
      and numerous dense lysosomic bodies, indicative of metabolic hyperactivity. On
      the basis of these morphological date, the tumour may be defined as an
      astrocytoma, the blastic tendency of which cannot be affirmed, other than on the
      basis of the presence of mitotic figures.

PMID- 1034455
TI  - Isolation of Blastomyces dermatitidis from pigeon manure.
AB  - We recently diagnosed and treated a 45-year-old white male horticulturist with
      acute progressive blastomycosis. Epidemiologic studies revealed that the patient
      used a load of pigeon manure as fertilizer approximately 6 weeks before becoming
      ill. He used the pigeon manure only once, resealed the remainder, and stored it
      in his hothouse. Samples of the pigeon guano were digested with 10 per cent KOH,
      and the characteristic yeast forms of Blastomyces dermatitidis were seen in large
      numbers. The fungus was cultured from another sample of the same material. This
      is the first time that the pathogenic fungus B. dermatitidis has been isolated
      from the environment in association with a human case.

PMID- 1034456
TI  - [Salivary gland involvement during various anti-inflammatory treatments. Apropos
      of 2 cases].

PMID- 1034457
TI  - [Isolation of a new sterol, portensterol, from carpophores of Tricholoma
      portentosum (Fr. Qu.), Rhodopaxillus nudus (Bull. ex Fr. Maire) and Clitocybe
      nebularis (Batsch. ex Fr.)].

PMID- 1034458
TI  - Genetic control of serum hemopexin.
AB  - Serum hemopexin was studied in a sample of twin pairs. Among monozygotic twin
      pairs a high concordance was found for serum hemopexin. This zygosity group
      analysis of variance also showed a significantly lower variance within than
      between pairs. The results indicate that the concentration of serum hemopexin is
      strongly influenced by genetic factors.

PMID- 1034459
TI  - Incubation of double labelled coproporphyrinogen with chicken red cell
      haemolysates, chemical and TLC fractionation of extracts.
AB  - Further evidence is presented for the enzymic conversion of protoporphyrinogen to
      protoporphyrin by observing the loss of 3H counts by 3H and 14C labelled
      coproporphyrinogen when incubated in chicken red cell haemolysates. Use was made
      of chemical and TLC fractionation of porphyrin extracts after incubation and a
      loss of half the 3H was again found. Evidence is presented for the role of
      harderoporphyrinogen as a natural intermediate in this conversion. The relevance
      of the findings in the porphyrias, and in particular variegate porphyria, is
      discussed. It is suggested that the enzymic process involved in the conversion of
      protoporphyrinogen to protoporphyrin may be deficient in variegate porphyria.

PMID- 1034460
TI  - Serum growth hormone and free fatty acid levels in heifers and cows before,
      during and after parturition.
AB  - A large number of blood samples was taken from the jugular vein of 18 cows or
      heifers during parturition, especially during stage II. In 9 animals an increase
      in serum growth hormone was observed and the peak occurred within the period
      which began when the forelegs of the calf became visible in the vulva, and ended
      a few minutes after expulsion of the calf. In typical cases, the growth hormone
      peak was preceded by a progressive increase, and followed by a gradual decrease
      in the hormone level. The total duration of the phenomenon amounted to a few
      hours. During the days before and after parturition, no change in growth hormone
      concentration could be noted. The serum free fatty acid values were high during
      parturition.

PMID- 1034461
TI  - [Interaction of androgens with uterine receptors].
AB  - Interactions of testosterone and 5 alpha dihydrotestosterone with the estrogen
      receptor have been studied in the immature rat uterus. At low concentrations,
      androgens interact with their own receptors (1) which are different from the
      estrogen receptor by their specificity, sedimentation constant and number of
      binding sites (2) (Table I). At high concentrations, androgens interact with the
      estrogen receptors, as shown by "rate" competitive experiments performed on
      uterine cytosol. This low affinity interaction is efficient to translocate the
      estrogen receptor to the nucleus in vitro (3) and in vivo (fig. I). Androgens
      also bind to the progesterone receptor. The responsibility of these interactions
      in the observed uterotrophic and anti estrogenic effect of androgens will be
      discussed.

PMID- 1034462
TI  - Origin of erythropoietic stem cells in avian development: shift from the yolk sac
      to an intraembryonic site.
AB  - Haemopoietic stem cells are currently considered as deriving exclusively from the
      embryonic yolk sac in birds and mammals. A new experimental approach has been
      devised: quail embryonic bodies are grafted on to chick yolk sacs before
      establishment of circulation, and allowed to develop. The proportions of quail
      and chick erythrocytes in the circulating blood are assayed through a
      differential immunohaemolysis technique. Up to 10 days of incubation, grafted
      quails have 80 to 95% chick erythrocytes. Between 10 and 13 days, quail
      erythrocytes appear in increasing proportions making up as much as 80% of the red
      blood cells in some embryos. Morphological analysis reveals that chick cells
      colonize transiently the spleen of grafted embryos between 10 and 12 days, and
      undergo erythropoiesis in that organ. However at 13 days chick cells have
      disappeared from the spleen of grafted embryos. It is concluded that yolk sac
      stem cells are capable of colonizing intraembryonic organs, but do not do
      permanently and that there is an intraembryonic source of definitive
      erythropoietic stem cells.

PMID- 1034463
TI  - Changes in haemoglobin and antigenic constitution of erythrocytes during
      embryonic and postembryonic chick development.
AB  - Between the 18th and 20th day of incubation, the proportion of haemoglobin F (Hb
      F) synthesis decreases in the embryo bone marrow from the value found in the yolk
      sac (10% of the total haemoglobin synthesis) to the value found in the bone
      marrow of young chicks (2%). A similar drop in Hb F synthesis is observed with a
      delay of 48 hours in the blood. Two membrane antigens each specific of either
      embryo or adult erythrocytes have been detected. The study by immunofluorescence
      of their cellular distribution shows that 3 erythrocyte populations are
      successively produced: a population E bearing the embryonic antigen only, a
      population EA bearing both antigens and a population A bearing the adult antigen
      only. The presence of a relatively high proportion of Hb F in population E is
      strongly suggested by the similar kinetics of Hb F and E cells disappearance
      within the first posthatching month.

PMID- 1034464
TI  - Mouse foetal development: translational inactivation of globin genes during the
      terminal differentiation of yolk sac erythroid cells.
AB  - The molecular mechanism of globin genes inactivation has been explored at the
      translational level in yolk sac erythroid cells from mouse foetuses. Ageing of
      the messenger molecules is paralleled by a progressive decrease of the poly(A)
      tail. Poly(A) less messengers are less active when tested in a wheat germ cell
      free system and become uncapable to terminate globin chain elongation.

PMID- 1034465
TI  - Restorative effects of different embryonic cells transplanted into
      immunodeficient chick embryos.
AB  - Cyclophosphamide-treated 18-day chicken embryos were transplanted with cells from
      different organs of histocompatible embryonic donors. The cells transplanted
      include cells from the bursa of Fabricius, spleen, bone marrow, thymus or liver
      of 15- and 18-day embryos and yolk sac cells from 9, 11, 13, 15 and 18-day
      embryos. To evaluate the reconstitution capacity of the cells transplanted, gain
      of body weight, weight and microscopic morphology of the lymphoid organs and
      antibody forming capacity to sheep red blood cells and Brucella were assessed at
      the age of five weeks. According to all the criteria employed, bursa cells were
      the only cells capable of a functional and morphological reconstitution of the
      recipient's humoral immune system. Cells from the embryonic spleen, bone marrow,
      thymus, liver or yolk sac had no reconstituting effect, indicating that these
      organs do not harbor precursors for the B-cell lineage. Taken together with other
      observations, these findings reveal that, as a differentiation site of the B-cell
      lineage, the bursa of Fabricius precedes the bone marrow during ontogenetic
      development, and furthermore, that the role of the yolk sac as the first
      generator of prebursal stem cells must be questioned.

PMID- 1034466
TI  - Migration of yolk sac cells to thymus grafts: requirement of prior sojourn in
      bone marrow (or liver?).
AB  - The migration of CBA/HT6T6 haemopoietic cells (adult bone marrow, embryonic liver
      or yolk sac) to established thymus grafts, in CBA/H 60-day neonatally
      thymectomized hosts, shows that all three cell types can migrate and divide
      within the grafts, albeit yolk sac cells appear later after cell injection. This
      last observation suggested possible intermediate steps, i.e. a sojourn in bone
      marrow (or liver in the embryos). When the same experiments were performed in
      hosts that had been pre-treated with 100 muCi of 89Sr (a bone seeking isotope),
      it was observed that marrow and embryonic liver cells still could migrate to
      thymus and subsequently generate a population of competent T lymphocytes, while
      yolk sac cells were incapable of such migration.

PMID- 1034467
TI  - Antifungal properties of electrically generated metallic ions.
AB  - A qualitative and quantitative investigation was undertaken to study the
      susceptibility of unicellular eucaryotic organisms (yeasts) to metallic cations
      generated by low levels of direct current. Results were characteristic of effects
      obtained previously using clinical and standard bacteria test organisms. The
      present study demonstrated that anodic silver (Ag(+)) at low direct currents had
      inhibitory and fungicidal properties. Broth dilution susceptibility tests were
      made on several species of Candida and one species of Torulopsis. Growth in all
      isolates was inhibited by concentrations of electrically generated silver ions
      between 0.5 and 4.7 mug/ml, and silver exhibited fungicidal properties at
      concentrations as low as 1.9 mug/ml. The inhibitory and fungicidal concentrations
      of electrically generated silver ions are lower than those reported for other
      silver compounds.

PMID- 1034468
TI  - [Epidemiology of avitaminosis A in Niger].

PMID- 1034469
TI  - [Enrichment of wheat flour with sunflower and soya flour for bakery products].
AB  - In order to improve the nutritive value of wheat protein, with a wheat flour,
      defated soybean flour and sunflower seed flour were mixed on the basis of their
      amino acid composition. The highest nutritive value, 86 expressed as CS, was
      obtained with 60% wheat flour + 28% defatted soybean flour + 12% defatted
      sunflower seed flour. The mixture was used to prepare: a) sea-biscuits, baked in
      a traditional bakery oven, and b) crackers, baked in an electric endless oven.
      Similar products, baked with wheat flour alone, were studied as controls.
      Chemical composition, total lysine, methionine, cystine, threonine and available
      lysine content were determine on the raw flours and mixture. Protein, fats and
      available lysine were determined on the bakery products. The nutritive value of
      the latter was assessed by their NPUop from which NPUst was calculated. The
      results showed an increase in the protein content of the enriched bakery products
      up to 60% over the controls. The nutritive value of the products was lower than
      the calculated figure for the raw mixture. Products b had the highest NPUst
      (56.4), surpassing the figures for the control (33.3) and also for product a
      (53.5). These values agreed with the figures for lysine availability which
      decreased with heat according to the cooking process. These data and the good
      acceptability of the crackers suggest that their enrichment with soybean and
      sunflowers seed concentrates asayed, could help to fulfill protein requirements
      in children.

PMID- 1034470
TI  - [Cerebral gigantism in twins].
AB  - Two probably monozygotic twins with cerebral gigantism are reported. They showed
      three typical features: pneumo-encephalography demonstrated a fifth anterior
      ventricular dilatation; in both patients dermatoglyphic findings showed a thenar
      exit of the Aline and a vertical palmar alignement; Growth hormone and
      sulfatation factor blood concentration were low but within normal limits.

PMID- 1034471
TI  - Two feminized male American Indians.
AB  - Two American Indian males are described who wish to change sex. Both appear to be
      anatomically normal; one is a monozygotic twin. In both cases, feminine
      identification began very early in life. In both cases, there were early
      acceptance and positive reinforcement of the feminine behavior. These two males
      and the environment in which they live are contrasted with the anthropological
      literature published decades ago describing the unique Indian tribal role played
      by feminized males.

PMID- 1034472
TI  - [Studies on the effect of raw protein supply on the lysine requirements in young
      pigs of living weight of 12-40 kg. 2. Report. Feeding studies with wheat-soy bean
      extraction residues].
AB  - A feeding trial was conducted on a total of 96 pigs to investigate the effect of
      lysine supplements added to rations of wheat+extracted soya bean meal and rations
      of wheat+extracted gound nut meal. Significant differences in the daily weight
      gains were noted (up to the 4th week of experiment) between the groups fed the
      soya bean meal ration and those fed the ground nut meal ration and between the
      soya bean meal groups receiving rations supplemented with 0,71% lysine or 0.79%
      lysine. At the termination of the trial (8th week) these differences were no
      longer significant statistically although the soya bean meal group fed rations
      supplemented with 0.79% lysine yielded clearly the best results.

PMID- 1034473
TI  - [Amniotic amputation (author's transl)].
AB  - This report is upon a new-born child whose intra-uterine amputated right hand was
      found in the placenta. Besides there was a syndactylism together with the missing
      of the middle and end phalnges of the long fingers of the left hand. Individual
      observations have been reported and the question of exogenous or endogenous
      causes for the so-called amniotic amputation is being discussed.

PMID- 1034474
TI  - Stress and increase of the corticosterone level prevent imprinting in ducklings.

PMID- 1034475
TI  - Social behaviour of testosterone-injected male ducklings in the presence of
      oestrogen-treated females.

PMID- 1034476
TI  - [Sensory and behavioral physiologic observations on the hunting dog].

PMID- 1034477
TI  - Purification of an exo-beta-D-glucanase from cell-free extracts of Candida
      utilis.
AB  - beta-Glucanase present in cell-free extracts from Candida utilis was isolated and
      purified 562-fold by procedures that include adsorption on DEAE-Sephadex A-50 and
      filtration through columns of Sephadex G-50, G-100 and G-200, Bio-Gel P-10, and
      Concanavalin A-Sepharose 4B. The purified enzyme appeared homogeneous on
      polyacrylamide-gel electrophoresis and in ultracentrifugation studies (S20,w =
      1.74S). The enzyme behaved as an acidic glycoprotein (pI4.1) with 68%
      carbohydrate and a high content of acidic amino acids. The mol.wt. was estimated
      to be 20000 from gel filtration and polyacrylamide-gel electrophoresis and 36000
      from sedimentation experiments. Studies on the hydrolysis of different substrates
      showed that the enzyme is an unspecific beta-glucanase able to break down both (1
      leads to 3)-eta- and (1 leads to 6)-beta-linkages by an exo-splitting mechanism.
      Glucono-delta-lactone, Zn2+ and Hg2+ inhibited the enzyme activity.

PMID- 1034478
TI  - Inactivation of dihydrofolate reductase in vitro by binding to microsomal
      membranes.

PMID- 1034479
TI  - Dopamine--adaptive uptake changes in striatal synaptosomes after 30 sec of shock
      induced fighting.

PMID- 1034480
TI  - Hypertrophic cardiomyopathy in Friedreich's ataxia.
AB  - The cardiac findings in two sibs with Friedreich's ataxia are described. The
      clinical signs were suggestive of hypertrophic obstructive cardiomyopathy. During
      left heart catheterization a systolic pressure gradient across the left
      ventricular outflow tract could be provoked by an infusion of isoprenaline. Left
      ventricular angiocardiograms and echocardiograms showed gross thickening of the
      interventricular septum. In one patient a systolic anterior movement of the
      anterior leaflet of the mitral valve was seen. The importance of serial
      echocardiographic examination for patients with Friedreich's ataxia is
      emphasized.

PMID- 1034481
TI  - Motor activity changes in scrapie-affected mice.
AB  - Measurements of spontaneous motor activity using Animex equipment have been made
      throughout the incubation period in mice developing scrapie. A progressive fall
      in activity has been noted from an early stage in the disease process well before
      clinical signs of scrapie were evident. The initial fall was followed by an
      upsurge in activity at about the time when clinical signs of disease develop.

PMID- 1034482
TI  - Components of the haemostatic mechanism at birth in pre-eclampsia with particular
      reference to fetal growth retardation.
AB  - A comparative study of proteinuric pre-eclampsia and normal pregnancy has been
      carried out to assess changes in the haemostatic mechanism in maternal and
      umbilical vein blood at birth. The results demonstrated changes in pre-eclampsia
      compatible with hypercoagulability with, in particular, depressed fibrinolysis.
      No strong pattern of differences from normal pregnancy or pre-eclampsia emerged
      when growth retarded infants were studied as a separate group.

PMID- 1034483
TI  - The ultrastructure of the arterial supply of the human placenta in pregnancy
      complicated by fetal growth retardation.
AB  - The ultrastructure of the arterial supply of the human placenta was studied in 15
      pregnancies with severe fetal growth retardation. There were five patients with
      essential hypertension and superimposed pre-eclampsia, five patients with pre
      eclampsia, and five patients with no hypertension. The patients were delivered by
      elective Caesarean section and biopsies of the placental bed were taken under
      direct vision. Extensive placental infarction was invariably present and the
      degree of infarction reflected the extent of pathological changes in the spiral
      arteries. In both hypertensive and normotensive patients the spiral arteries and
      basal arteries of the decidua showed occlusive atheromatous lesions with
      considerable fibrin deposition and accumulation of lipid-laden cells in both the
      intima and media of the vessel walls.

PMID- 1034484
TI  - The effect of different diets including those containing soya-bean products, on
      digesta movement and water and nitrogen absorption in the small intestine of the
      pre-ruminant calf.
AB  - 1. Preruminant calves, fistulated in the abomassum and distal ileum, were given
      by infusion into the abomasum, at intervals of 2-3 d, single experimental feeds
      of cow's milk or a synthetic milk diet in which the protein source was casein or
      a soya-bean product. Polyethylene glycol (PEG) and phenol red were included as
      markers. 2. After infusion of the experimental feed, measurements were made of
      transit time from proximal duodenum to distal ileum and mean ileal flow-rates for
      the first 3 and 21 h after food residues reached the distal ileum. PEG recoveries
      for these two periods and net nitrogen absorption up to the distal ileum were
      also determined. In some experiments sodium, potassium and magnesium
      concentrations and numbers of viable bacteria in ileal digesta were determined.
      3. Measurements of passage of digesta, recovery of marker and net N absorption
      did not differ greatly between calves given cow's milk and the synthetic milk
      diet containing casein. Compared to the casein-based diet, a diet based on heated
      soya-bean flour given to a calf for the first or second time produced a somewhat
      higher ileal flow-rate and a significantly lower net N absorption. Net N
      absorption was even lower when a calf received a diet containing unheated soya
      bean flour. 4. Calves given the diet containing heated soya-bean flour on several
      occasions appeared to develop a sensitivity to the flour, and after further feeds
      containing it they had significantly higher rates of ileal flow (accompanied by
      correspondingly high rates of Na and K flow), lower small intestine transit times
      and lower net N absorption values than similarly fed unsensitized calves. They
      also had significantly lower rates of passage of marker in the first few hours
      after food residues reached the ileum, indicating inhibition of abomasal
      emptying. Over all, the changes indicated a severe disturbance in digestive
      function which was not caused by abnormal bacterial growth and may have been due
      to a gastrointestinal allergy. 5. Diets prepared from water-extracted flour and
      from soya-bean-protein isolate also led to digestive disturbances in sensitized
      calves, but those containing concentrates prepared by extracting soya-bean meal
      with hot aqueous ethanol did not.

PMID- 1034485
TI  - Glycogen degradation during migration of presumptive cell types in Dictyostelium
      discoideum.
AB  - During the time course of differentiation in Dictyostelium discoideum, glycogen
      was found to accumulate from the amoebae stage to the culmination stage of
      development. Upon sorocarp formation (23 h), glycogen was rapidly degraded.
      Ultramicrotechniques, utilizing amplification of glycogen by enzymatic cycling,
      were used to follow glycogen metabolism in pre-stalk and prespore cells during
      the differentiation cycle. Both cell types accumulated glycogen at nearly the
      same rate. By the pseudoplasmodium stage of development glycogen had accumulated
      to 50% of its maximum value, and no differences were found between pre-stalk and
      pre-spore cells. Glycogen was degraded as pre-stalk cells migrated into the
      position for stalk construction. At the culmination stage of development stalk
      cells near the base were devoid of glycogen while pre-stalk cells near the apex
      of the stalk showed no loss of glycogen. The complete loss of glycogen from stalk
      cells occurred over a distance occupied by approximately 100 cells, and over a
      time period of approx. 1 h. Pre-spore cells at the culmination stage showed no
      loss of glycogen even though separated from stalk cells by only a thin cellulose
      sheath. The degradation of prespore cell glycogen did not commence until stalk
      construction was completed and the pre-spore mass had reached the apex of the
      stalk. Pre-spore cells at the culmination stage contained high levels of glycogen
      while only 2 h later, total degradation had occurred.

PMID- 1034486
TI  - Induction of delta-aminolevulinic acid synthetase by flutamide, a non-steroidal
      antiandrogen.

PMID- 1034487
TI  - Identification of 6-ketoprostaglandin F1alpha formed from arachidonic acid in
      bovine seminal vesicles.
AB  - The prostaglandin synthesizing system in bovine seminal vesicles was
      characterized by a radiometric assay. Two main products were formed from [1-14C]
      arachidonic acid, and their structures were confirmed by mass spectrometry. The
      less polar product was identical with prostaglandin E2 and the more polar one was
      identical with a new prostaglandin, i.e., 6-ketoprostaglandin F1alpha.

PMID- 1034488
TI  - [Microspectrophotometric study of loach oocytes after treatment with
      dimethylsulfate].
AB  - It has been shown by microspectrophotometric studies of loach oocytes that after
      DMS effect RNA concnetration in the cytoplasm cells is 3.3 times higher in the
      experiment than in the control; in the nucleoli it is 2.3 times higher. The
      increase of RNA concentration in some strucutres of loach oocytes affected with
      DNS seems to be indicative of the strengthening intensity of synthetic processes
      in these cells.

PMID- 1034489
TI  - [Formation of aggressive behavior in the domestic mouse (Mus musculus L.). I.
      Effect of older males on the aggressiveness of young animals].

PMID- 1034490
TI  - Live television transmission of transurethral and open pelvic surgery with
      reproduction a a big screen.

PMID- 1034491
TI  - Noxytiolin and peritoneal adhesion formation.
AB  - Clinical and experimental studies have suggested that intraperitoneal noxytiolin
      prevents adhesion formation. A reliable experimental animal model was therefore
      established and the effect of noxytiolin on adhesion formation was evaluated in a
      controlled trial using 80 rats. All 40 rats given Ringer solution developed
      adhesions, whereas in 7 out of 40 given noxytiolin no adhesions were found (P
      less than 0-02). Noxytiolin reduced both the total and the mean number of
      adhesions formed (P less than 0-2) and their mean length of attachment (P less
      than 0-05). The anti-adhesive effect of noxytiolin may be due to its
      anticoagulant, cytotoxic or antibacterial properties.

PMID- 1034492
TI  - Psychological problems of students.

PMID- 1034493
TI  - High affinity uptake in neuronal and glial cells.

PMID- 1034495
TI  - [Epidemic of tick-borne encephalitis in Zavada. results of epidemiologic
      examinations (author's transl)].

PMID- 1034494
TI  - Organization of brainstem behavioral systems.
AB  - A review of recent literature suggests that the brainstem may play a more
      fundamental role in the elaboration of adaptive behaviors than has often been
      assumed. This view is indicated by current reports documenting the substantial
      behavioral repertoire of decerebrate animals and by the recent findings that
      electrical stimulation of localized areas in all major levels of the brainstem
      can induce complex and coordinated behaviors, including eating, grooming and
      attack. Indeed, behaviors elicited from sites in the caudal brainstem evidence
      unexpected goal specificity and stimulus control over response topography.
      Additional neuroanatomical and behavioral data are reviewed which further
      implicate caudal brainstem networks in process of reward and aversion. From these
      and other findings it is argued that integrating mechanisms for the expression of
      many aspects of species-characteristic behaviors are intrinsic to the brainstem.
      In line with this view, rostral hypothalamic-limbic mechanisms, while perhaps
      contributing refinement to the integration of behaviors, may best be viewed as
      phylogenetically newer control mechanisms making the expression of species
      characteristic behaviors subordinate to additional class of exteroceptive and
      interoceptive stimuli.

PMID- 1034496
TI  - [Clinical observation of tick-borne encephalitis epidemic in Zavada (author's
      transl)].

PMID- 1034497
TI  - Comparative zone electrophoresis of catalase of Staphylococcus species isolated
      from mammalian skin.
AB  - Vertical polyacrylamide slab gel electrophoresis was conducted for the catalase
      enzymes of representative strains of 18 proposed species and subspecies of the
      genus Staphylococcus. The catalase bands which resulted were predominantly
      monomorphic within each of the species and differences in catalase mobilities
      were observed between many of the species. The electrophoretic mobilities of the
      catalases were supportive to the scheme of classification used. Many strains of
      certain species demonstrated multiple catalase bands which are suggestive of
      multimolecular forms of the enzyme. Horizontal starch gel electrophoresis of
      representative strains of S. capitis produced catalase bands with relative
      mobilities that were different from those obtained with polyacrylamide
      electrophoresis, presumably due to a difference in molecular sieving between the
      gels.

PMID- 1034498
TI  - Activation and killing of Dictyostelium discoideum spores with urea.
AB  - The optimal conditions for activation of Dictyostellium discoideum spores are an
      8 M urea treatment for 30 min. The lag between activation and swelling is 45 min.
      Lower concentrations of urea do not activate entire spore populations. Incubating
      spores in 8 M urea for 60 min or treatment with 10 M urea for 30 min results in a
      lengthening of the post-activation lag and a decrease in the final percentage of
      germination. Urea-activated spores can be deactivated by azide, cyanide, osmotic
      pressure, and low-temperature incubation. Activated spores do not germinate if
      incubated in 1 M urea for 24 h but will complete germination upon resuspension in
      urea-free buffer. Shocking spores at 45 degrees C in 8 M urea or incubating
      spores in 4-8 M urea for 10 h at 23.5 degrees C causes inactivation. When
      suspended in urea-free buffer, a larger percentage of these dead spores release
      spheroplasts through a longitudinal split in the spore case. Sequential enzyme
      treatment of spheroplasts with cellulase and pronase causes them to release
      lysable protoplasts. The data of these experiments suggest that shedding of the
      outer and middle wall layers during physiological spore swelling may be a
      physical process rather than an enzymatic one.

PMID- 1034499
TI  - Pre- and postoperative echocardiographic features of discrete subaortic stenosis.
AB  - In two patients with discrete membranous subaortic stenosis, partial early
      systolic closure of the aortic valve was noted on the preoperative record.
      Postoperatively, this abnormality was found to be less pronounced. Narrowing of
      the left ventricular outflow tract was seen in the preoperative tracing in each
      patient. Echocardiograms taken after resection of the subaortic membrane showed
      widening of the left ventricular outflow tract as compared with the preoperative
      tracing. Thus, echocardiography may be of value in distinguishing between
      discrete subaortic stenosis and other forms of left ventricular outflow tract
      obstruction.

PMID- 1034500
TI  - Organization of the ribosomal RNA genes of Dictyostelium discoideum: mapping of
      the nontranscribed spacer regions.
AB  - Most of the Dictyostelium ribosomal nontranscribed spacer DNA has been mapped
      using Eco R1, Hind III, and Sal I restriction digests and recombinant plasmids
      containing parts of the rDNA (ribosomal DNA). The repeat units are at least 42 kb
      (1 kilobase = 1000 base pairs = 1 kb) long; of this, 8 kb codes for the 36S rRNA
      precursor. The repeat units give a homogeneous pattern of Sal I, Eco R1, and Hind
      III restriction fragments. The repeats could be linked by a heterogeneous region
      in the nontranscribed spacer, not tandemly repeated, or linked in a more
      complicated structural arrangement. The total rDNA comprises at least 18% of the
      nuclear DNA.

PMID- 1034501
TI  - The synthesis of immunoglobulins by lymphoid cells in the sheep. The contribution
      made by the lymphoblasts to the total immunoglobulin and antibody production by
      lymphoid cells of the popliteal node during a secondary response to bacterial
      lipopolysaccharide.

PMID- 1034502
TI  - Studies on vasculitis. VII. C-reactive protein as a substance perpetuating
      chronic vasculitis. Occurrence in lesions and concentrations in sera.
AB  - Previous findings were confirmed that C-reactive protein (C-RP) occurs in some
      vasculitis lesions, particularly those infiltrated mainly by neutrophils
      (necrotizing vasculitis). The C-RP was usually in lesions also containing
      complement C1 or C3c, and in some, IgG was present. Using a procedure that
      reliably detected 200 ng C-RP/ml serum, C-RP was found in sera of many normal
      persons, and the amount was influenced by the occupation of the donor. Sera of
      thirty-one persons with vasculitis with mainly mononuclear cell-infiltrated
      lesions had about four-fold more C-RP (mean 28, 200 ng/ml serum) than found in
      normal persons, and sera of thirty-nine persons with mainly neutrophil
      infiltrated lesions had eight times the normal amount (mean 56,400 ng C-RP/ml).
      The amount of C-RP was influenced by the severity, extent and duration of the
      disorder in most patients. Experimental data suggests that C-RP may contribute to
      the perpetuation of inflammation in chronic vasculitis.

PMID- 1034503
TI  - [Pathology of primary hyperparathyroidism; with special reference to primary
      chief cell hyperplasia].

PMID- 1034504
TI  - [Hyperparathyroidism of a mother discovered in connection with development of
      tetany in her newborn infant].

PMID- 1034505
TI  - [Case of primary hyperparathyroidism diagnosed after bone fracture during
      dialysis therapy for kidney failure].

PMID- 1034506
TI  - [Clinical studies of blood prolactin].

PMID- 1034507
TI  - [Case of thyroid storm after labor].

PMID- 1034508
TI  - [Preliminary evaluation cortisol determination kits by competitive protein
      binding analysis].

PMID- 1034509
TI  - [Primary hyperparathyroidism as a clinical problem].

PMID- 1034510
TI  - [Detection of primary hyperparathyroidism].

PMID- 1034511
TI  - [Approaches in diagnosis of primary hyperparathyroidism].

PMID- 1034512
TI  - [Diagnosis and localization of primary hyperparathyroidism by radioimmunoassay of
      plasma PTH].

PMID- 1034513
TI  - [Chemical hyperparathyroidism].

PMID- 1034514
TI  - [Pre-operative localization surgery and postoperative care of primary
      hyperparathyroidism].

PMID- 1034515
TI  - [Radioimmunoassay of serum 11-deoxycorticosterone (DOC)].

PMID- 1034516
TI  - [Determination of hCG with anti-hCG-beta serum sensitized erythrocytes-
      application to a pregnancy test in the early stage].

PMID- 1034517
TI  - [Differences in LH levels (CGeq) according to methods of determination and
      individuals and interference of LH in determination of hCG-beta subunits].

PMID- 1034518
TI  - [Studies on serum prolactin measurement with prolactin radioimmunoassay-kit
      (CIS)].

PMID- 1034519
TI  - [Cortisol kit "Dai-ichi"].

PMID- 1034520
TI  - [Clinical study of thyroxine determination with Tetralute].

PMID- 1034521
TI  - [Simple measurement of serum aldosterone with 125I-aldosterone].

PMID- 1034522
TI  - [Distinction in clinical application of various thyroid hormone tests (T4, T3, T3
      absorption test, and free T4 index)].

PMID- 1034523
TI  - [Determination of serum insulin and its significance in diagnosis and management
      of diabetes mellitus].

PMID- 1034524
TI  - [Conditions requiring determination of plasma renin activities in hypertension,
      and definition of low renin hypertension].

PMID- 1034525
TI  - [Differential diagnosis of amenorrhea with hirsutism].

PMID- 1034526
TI  - [Serum gastrin levels in chronic renal failure].

PMID- 1034527
TI  - [The mechanism responding to tissue anoxia, with special reference to the effects
      of corticosteroid on erythrocyte 2,3-DPG].

PMID- 1034528
TI  - [Effects of glucocorticoids on gonadotropin secretion].

PMID- 1034529
TI  - [Serum T3 determination with Seralute. Experimental studies and clinical
      application].

PMID- 1034530
TI  - [Micro-analysis of biological catecholamines with gas chromatography and mass
      spectrum analysis].

PMID- 1034531
TI  - [Serum thyroxine determination with T4 RIA kit].

PMID- 1034532
TI  - [125 I-cortisol radioimmunoassay--clinical studies].

PMID- 1034533
TI  - Physical dependence in the rat induced by slow release morphine: dose-response,
      time course and brain biogenic amines.
AB  - 1. Physical dependence was induced in rats by administration of a slow release
      morphine emulsion (morphine SR), and assessed by scoring abstinence signs and
      temperature changes after i.p. administration of naloxone (5 mg/kg). Three groups
      of rats received doses of 75, 100 or 150 mg/kg of morphine SR. Dependence was
      evaluated in each of these groups after 24, 48 and 72 h. 2. The effect of these
      treatments at the different times on brain levels of serotonin, 5
      hydroxyindoleacetic acid, noradrenaline and dopamine was determined. 3. A ceiling
      level of dependence was reached 24 h after 75 and 100 mg/kg and 48 h after 150
      mg/kg of morphine SR. 4. These different treatments produced no significant
      effect on the brain levels of noradrenaline, dopamine or serotonin. The levels of
      5-hydroxyindoleacetic acid were significantly raised in morphine-dependent rats
      and the changes correlated well with the changes in abstinence behaviour and
      temperature after naloxone. 5. The results suggest that a relationship exists
      between serotonin turnover and physical dependence on morphine.

PMID- 1034534
TI  - Rhabdomyosarcoma of the spermatic cord.

PMID- 1034535
TI  - [Aphasia and localization of brain lesions. Part 3: 4 cases of crossed aphasia in
      dextrals].

PMID- 1034536
TI  - [Case of congenital paramyotonia with an abnormally high level of serum creatine
      phosphokinase].

PMID- 1034537
TI  - [Case of Gerstamann's syndrome associated with unique telangiectasia].

PMID- 1034538
TI  - [Spinal dystonia, with special reference to a case with dystonic postures of the
      left arm induced by cervical spinal cord dsyfunction].

PMID- 1034539
TI  - [Case of ventrally situated brain stem meningioma associated with forced
      laughter].

PMID- 1034540
TI  - [Effect of blood pressure on recurrence of stroke--a 5-year follow-up study].

PMID- 1034541
TI  - 2 cases of progressive spinal muscular atrophy with carbon dioxide narcosis.

PMID- 1034542
TI  - [Idiopathic dystonia with oppositional movement and flapping-like tremor, and the
      therapeutic effect of levodopa].

PMID- 1034543
TI  - [Free amino acids in the spinal cord of a patient with amyotrophic lateral
      sclerosis].

PMID- 1034544
TI  - [Aseptic meningitis as a manifestation of craniopharyngioma. Report of 2 cases
      and etiological observation].

PMID- 1034545
TI  - [Capillary telangiectasis of the brain. Report of 2 autopsy cases and review of
      ther literature].

PMID- 1034546
TI  - [Case of myasthenia gravis associated with pemphigus vulgaris following
      thymectomy. Immunological studies and a review of the literature].

PMID- 1034547
TI  - [Case of amyotrophic lateral sclerosis with neurofibrillary changes].

PMID- 1034548
TI  - [Family with hereditary polyneuropthy assoicated with pyramidal signs].

PMID- 1034549
TI  - [Effects of diphenylhydantoin on myotonia and biopsy findings of the muscle].

PMID- 1034550
TI  - Organ culture in teratology.

PMID- 1034551
TI  - Developmental anomalies arising from errors of fertilization and cleavage.

PMID- 1034552
TI  - [Natural and induced ovulation in sables (Martes zibellina L)].

PMID- 1034553
TI  - [Report of the text book program committee of WHO/PAHO for teaching community
      health nursing].

PMID- 1034554
TI  - Binding of testosterone in mouse plasma.
AB  - The binding of testosterone (T) in the plasma of adult male mice was examined
      using florisil absorption. The binding decreased as the temperature of incubation
      increased, and was substantially reduced by preheating the plasma at 75 degrees
      C. The addition of an excess of cold T did not displace 3H-T, and the binding did
      not depend on the concentration of endogenous T in the plasma. It appears that,
      under physiological conditions, approximately 60% of the T present in the
      peripheral circulation of male mice is bound to plasma components, probably
      mostly to albumin.

PMID- 1034555
TI  - Regulation of adenylate cyclase in two rat liver cell lines, 3C4 and 62.
AB  - Adenylate cyclase (EC 4.6.1.1) activities were examined in membrane preparations
      from two rat liver cell lines (62 and 3C4) which were grown in monolayer
      cultures. The cells were epithelial-like in growth character. Adenylate cyclase
      from the line 62 was stimulated by epinephrine, Gpp(NH)p, and prostaglandins
      A1,A2,E1,E2, and F2alpha, but not by glucagon. Arrhenius plots of adenylate
      cylase activity from line 62 gave straight lines, except when epinephrine was
      present in the assay; epinephrine-stimulated activity gave a distinct break at 20
      degrees C. Adenylate cyclase activity in line 3C4 was stimulated by glucagon ten
      times greater than by epinephrine. It was responsive to Gpp(NH)p and all the
      prostaglandins. Arrhenius plots of adenylate cyclase activity of line 3C4 always
      gave straight line curves. Prostaglandins flattened the straight line curves
      (allowed temperature independence) of adenylate cyclase activity in membranes
      from both cell lines.

PMID- 1034556
TI  - Ectogalactosyltransferase. Presence of enzyme and acceptors on the rat lymphocyte
      cell surface.
AB  - Experiments are described to demonstrate the existence of
      ectogalactosyltransferase activity on the lymphocyte surface. The procedures
      described enable us to exclude the possibility of misleading results due to
      precursor hydrolysis and intracellular utilization of the free galactose. This
      depicted transferase is able to catalyse the transfer of a galactosyl residue
      from UDP-galactose to a nonphagocytosable exogenous acceptor and to endogenous
      membrane acceptors. The cells galactosylated in this way acquired new
      agglutinating properties with soybean agglutinin, which proves the external
      position of the galactosyl residues incorporated on the cell surface.

PMID- 1034557
TI  - Interference of nucleoside diphosphate derivatives of 2-deoxy-D-glucose with the
      glycosylation of virus-specific glycoproteins in vivo.
AB  - The predominant effect of 2-deoxy-D-glucose on chick embryo cells infected with
      Semliki Forest virus is an interference with glycosylation of virus-specific
      glycoproteins; this results in a block of synthesis of infectious virus.
      Incorporation of radioactive mannose is blocked severely in the presence of 2
      deoxyglucose in the cultural medium although it is readily phosphorylated and
      subsequently activated by GTP to yield GDP-mannose, which accumulates under these
      conditions. The intracellular concentrations of GDP-mannose and UDP-N-acetyl-D
      hexosamine are not reduced in the presence of the inhibitor. An equimolar
      concentration of mannose in the cultural medium competes with the inhibitory
      effect of the deoxysugar and drops the cellular pool of GDP-2-deoxy-D-glucose
      below the level of detection, at the same time restoring the synthesis of
      infectious virus. When the intracellular concentration of UDP-2-deoxyglucose is
      reduced by addition of glucose into the cultural medium the inhibition of virus
      synthesis by the deoxysugar and the concentration of GDP-2-deoxyglucose within
      the cells remain near to the values when the inhibitor is present alone. It is
      concluded that among the metabolites of 2-deoxyglucose which occur in vivo after
      addition of 2-deoxyglucose to the culture medium, GDP-2-deoxyglucose is the agent
      responsible for inhibition of glycosylation of viral glycoproteins.

PMID- 1034558
TI  - A functional arginine residue in rabbit-muscle aldolase.
AB  - Rabbit muscle aldolase is irreversibly modified by the arginine-selective alpha
      dicarbonyl, phenylglyoxal, loss of activity correlating with the unique
      modifications of one arginine residue per subunit, as determined by amino acid
      analysis, and (7-14C)phenylglyoxal incorporation. The affinity of the modified
      enzyme for dihydroxyacetone phosphate is significantly reduced while substantial
      protection against inactivation is afforded by fructose 1,6-disphosphate,
      dihydroxyacetone phosphate or phosphate ion. The nature of the substrate C-1
      phosphate binding site in this enzyme is discussed in the light of these and
      other results.

PMID- 1034559
TI  - Artificially produced urinary incontinence preparatory to enterocystoplasty of
      the small tuberculous bladder associated with severe renal insufficiency due to
      vesico-ureteric reflux. Long-term results.
AB  - The small contracted tuberculous bladder is often associated with vesico-uretenic
      reflux which, from the resultant ureteric and pelvic dilatation, is responsible
      in many cases for severe renal insufficiency which contraindicates
      entercystoplasty. In order to improve kidney function and consequently render
      plastic enlargement of the bladder feasible, it may be useful to induce complete
      incontinence of urine by means of wide TUR of the bladder neck extending to the
      external sphincter. By eliminating back pressure in the urinary tract,
      incontinence produces a regression of this dilatation and improved renal
      function. Following enterocystoplasty perfect continence is restored.

PMID- 1034560
TI  - DNA-binding characteristics of acridinylmethanesulphonanilide drugs: comparison
      with antitumour properties.

PMID- 1034561
TI  - Localization of Mycoplasma pulmonis in mice.
AB  - Localization of Mycoplasma pulmonis was examined in mice infected by direct
      contact with previously infected mice. After contact with infected animals, the
      organisms were shown to become detectable first in the nasal and oral cavities
      and trachea on the next day, and then they were recovered from the middle ear and
      brain after 3 and 4 days, respectively. After 7 days of contact, isolation rates
      retained to be 100% in the nasal, oral and tracheal cavities, while 95% in the
      middle ear and brain, 25% in the lung and 20% in the vagina and uterus. The
      number of colonies was the most numerous from the nasal, uterine and vaginal
      cavities, followed by the trachea, middle ear, oral cavity, brain and lung in
      this order, except for a few mice having pneumonic lesions giving a large number
      of the organisms. The isolation rates with these organs were not changed even
      after 6 weeks of contact and organisms were never detected from the liver,
      spleen, kidney and heart. Mice from a naturally infected breeding colony showed
      similar finding to those sacrificed after 6 weeks of experimental contact.

PMID- 1034562
TI  - Survival of 16-celled and morula stage rabbit embryos frozen to -196 degrees C,.
AB  - Preimplantation stage (16-celled and morula) rabbit embryos were successfully
      frozen to -196 degrees C. The cooling rate (from a room temperature to 0 degrees
      C), the presence of the mucin layer surrounding embryos, the ice-seeding
      treatment and the thawing procedure were examined to determine their effects on
      the survival of the frozen embryos of Japanese white, New Zealand white and Dutch
      Belted rabbits. A high proportion (51%; 16-celled, 69%; morula) of Dutch-Belted
      rabbit embryos developed in vitro, when they were frozen to -196 degrees C,
      applying the ice-seeding at -4 degrees C in the presence of 12.5% DMSO, after
      being cooled to 0 degrees C at the rate of 7-9 degrees C/min, and were diluted by
      a stepwise addition of 4 different strength PBS on thawing. The highest rate of
      in vitro development (81%; Japanese white, 75%; New Zealand white, 82%; Dutch
      Belted embryos) was obtained when the morula stage embryos were frozen to -196
      degrees C applying seeding at -4 degrees C after being cooled to 0 degrees C at
      the rate of 1 degrees C/2.5 min and were diluted, on thawing, by stepwise
      addition of 6, 3 and 1% DMSO solution and a culture medium. No great difference
      was found in the survival rate between the embryos covered with the mucin layer
      and those which had not the coat. All the embryos frozen without applying seeding
      treatment failed to develop in vitro after being thawed and diluted. Nine out of
      27 does each of which received 6 reimplantations of the embryos frozen-thawed
      became pregnant and were found to be carrying 37 normal fetuses on the 12th day
      of pregnancy.

PMID- 1034563
TI  - [Effects of the population density on growth of SD-JCL rats (author's transl)].
AB  - The effects of the population density on growth and life span of 21 to 26 months
      in SD-JCL-rats were investigated. The mean life spans of males and females were
      23 and 24 months, respectively. The population density had no definite influence
      on increase in body weight of females, whereas a most accelerated growth of males
      was seen with 2 rats per cage. The total amounts of food intake of each animal
      throughout its life were about 15 and 11 kg for males and females, respectively,
      and those of water intake were about twice the food. No correlation was observed
      between the population density and the weights of the liver, kidney, heart and
      femur, though mals reared at 5 animals per cage had lightest adrenals among all
      the animals.

PMID- 1034564
TI  - [Occurrence of the heterozygosity at Es-1 locus in a sub-strain of the NZB mice].
AB  - In the course of inspection of the biochemical marker genes in inbred strains of
      mice maintained in our laboratory, a female mouse of the NZB strain was found to
      be heterozygous for the Es-1 locus. Namely, it was Es-1a/Es-1b type. After this
      finding, many heterozygous mice were found among her sisters and the descendants.
      However, these heterozygotes (Es-1a/Es-1b) showed no heterozygosity for other 11
      characters, i.e., the 6 biochemical markers (Hbb, Trf, Es-2, Id-1, Mod-1, Gpd-1)
      and the 5 coat colour markers (A, B, C, D, AND S) were idential as those
      previously described. It was, moreover, observed that they possessed the
      immunological characteristics typical of the NZB mice. Therefore, it could be
      concluded that the heterozygosity had been originated from a single mutation at
      the Es-1 locus, i.e., from Es-1a to Es-1b or vice versa. With regard to the
      alleles at the Es-1 locus, an investigation was carried out in two sub-strains of
      the NZB mice having different breeding history and the followings were clarified.
      One substrain imported from Karolinska Institute, Sweden, had been fixed with the
      Es-1a allele and the other imported from England was found to be Es-1b/Es-1b
      type. The NZB mice which displayed the heterozygosity had been derieved from the
      Karolinska sub-strain. Importance of biochemical marker genes for inspection of
      proper maintenance of inbred strains has been discussed.

PMID- 1034565
TI  - [Application of the RaBA-System to clinical blood chemistry test in experimental
      animals].
AB  - Blood samples from rats, rabbits and beagles were subjected to simultaneous
      analyses for ten parameters using the RaBA-System and the results were compared
      with those obtained by the routine manual methods. Although the mean values
      measured by the two methods differ in several items, a significant correlation
      between the two methods in the majority of the determinations makes the use of
      the RaBA-System acceptable. The RaBA-System is thus considered to be applicable
      to evaluation of hemoglobin, total protein, glucose, BUN, total cholesterol, GOT,
      GPT, and alkaline phosphatase in blood samples from rats, rabbits and beagles.
      Plasma LDH and albumin, however, cannot be determined with accuracy by the
      system.

PMID- 1034566
TI  - [Clinical blood chemistry values in normal Wistar-Imamichi rats using the RaBA
      System (author's transl)].
AB  - In order to establish the normal baseline of blood values in rats using the RaBA
      System, the following eight parameters were analyzed in 8-22-week-old Wistar
      Imamichi rats of both sexes: hemoglobin, total protein, glucose, BUN, total
      cholesterol, GOT, GPT, and alkaline phosphatase. With the exception of glucose,
      all these parameters were significantly different depending upon ages.
      Significant sex differences were observed in the values of hemoglobin, total
      cholesterol, GOT, and alkaline phosphatase.

PMID- 1034567
TI  - [Establishment of two rat strains for testing coat color genes (author's
      transl)].
AB  - Two tester strains of the rats for testing coat color genes were established. The
      names, the origins and the genotypes of the rats were as follows: (1) abh (F4)
      Origin: selected from (BN/fMai X Kyo: Wistar) F2. Genotype: C/C, a/a, b/b, h/h.
      (2) bhd (F2) Origin: selected from (abh X Tester Moriyama)F2. Genotype: C/C, a/a,
      b/b, h/h, D/d and C/C, a/a, b/b, h/h, d/d.

PMID- 1034568
TI  - [Improvement and development of laboratory fish].

PMID- 1034569
TI  - [Age and breed characteristics of the diurnal rhythm of changes in the plasma
      insulin concentration of calves].

PMID- 1034570
TI  - [Dynamics of autonomic and bioelectric shifts in rats under emotional stress].
AB  - Obvious changes in the respiratory and cardiovascular systems and in the electric
      activity of the limbic structures were observed following time--scheduled
      stimulation: stage of anxiety, stage of adaptation, stage of exhaustion. The
      hippocampal structures were also involved in the process suggesting participation
      of the hippocampus in prognostication of the events. Three types of
      cardiovascular and respiratory responses were distinguished in the "anticipation
      of the stress" model: increased frequency, decreased frequency, relative
      stability of the rhythm. Prevalence of the sympathetic tonus was noticed.

PMID- 1034571
TI  - [Acid-base condition of the blood of rats following exposure to hyperoxic
      mixtures at atmospheric and elevated pressures].

PMID- 1034572
TI  - Distribution and mode of arrangement of microfilamentous structures and actin in
      the cortex of the amphibian oocyte.

PMID- 1034573
TI  - A freeze-fracture and concanavalin A-binding study of the membrane of cleaving
      Xenopus embryos.
AB  - The freeze-fracture appearance and concanavalin A-binding capacity of the plasma
      membrane of cells of the cleaving Xenopus embryo have been examined up to the 16
      cell stage. It was found that membrane on the outer surface of the embryo, which
      faces the vitelline membrane and is remote from cleavage furrows, and membrane in
      the shallow regions of the furrow possessed a high population of intramembranous
      particles on the PF-face (1171 per mum2). The EF-face of these membranes showed a
      lower particle population (245 per mum2). By contrast, membrane deep in the
      furrow and bounding the blastocoel did not display a face with high particle
      numbers. Both faces of this membrane, which is newly exposed as the furrow grows,
      were relatively poorly supplied with particles (93 per mum2). Therefore it
      appears that, in this tissue, newly added membrane possesses fewer
      intramembranous particles than the pre-existing membrane. Concanavalin A, as
      detected cytochemically using peroxidase and haemocyanin techniques, bound
      extensively to both particle-rich and particle-poor membrane. Thus there was no
      correlation between intramembranous particle frequency and degree of concanavalin
      A binding.

PMID- 1034574
TI  - [Systolic time intervals in obstructive hypertrophic cardiomyopathy. The effects
      of adrenergic beta-stimulation and beta-blockade in 38 cases (author's transl)].
AB  - The authors report on the behaviour of systolic time intervals, studied with a
      noninvasive poligraphic technique, under normal conditions, after adrenergic beta
      stimuls (orciprenaline) and successive beta blocker (pindolole) in 38 patients
      with obstructive cardiomyopathy. Under normal conditions, the authors observed a
      marked dispersion of PEP and TEVS data, which have, however, average normal
      values. The IPEP was reduced in 29% of cases, was normal in 47.3% and raised in
      23.7%; the ITEVS was reduced in 55.2% of cases, was normal in 21.1%, raised in
      23.7%; the PEP/TEVS was reduced in 23.7%, normal in 31.6% and raised in 44.7%.
      The beta stimulation demonstrated a number of behaviour patterns: the most
      frequent cause was a reduction of PEP in the cases where it had been raised or
      where it had remained within normal limits, an increase of TEVS in the cases
      where it had been diminished or normal, a reduction of the PEP/TEVS correlation
      where these values were increased or normal. The beta blocker, followed by beta
      stimulus, brought on variations opposite from those of the beta stimulation.
      Thus, one can consider the hypothesis that the possible behaviour patterns and
      combination of PEP and TEVS result from different anatomical and functional
      expressions that can become obstructive cardiomyopathy, according to the
      seriousness of the obstruction, the ventricular compliance and the contractility.

PMID- 1034575
TI  - [Role of echocardiography in the instrumental symptomatology of idiopathic
      hypertrophic cardiomyopathy].

PMID- 1034576
TI  - [Experimental skeletal teratogenesis: a disturbance of relative osteo-neural
      growth].
AB  - The previously suggested concept of the closest growth relations existing between
      the bony and the nervous tissue at the organ level of the spinal cord and the
      peripheral (including the facial) nervous trunks is experimentally buttressed. It
      is shown that the normal gross-morphological features of the vertebrae as well as
      of the tubular bones (viz., their length, physiological curvatures and terminal
      expansions) result from the adaptation of the bone growth to the slower
      proceeding and vulnerable neural extensive growth, viz., from a physiological
      osteo-neural growth disproportion. The more or less conspicuous growth in length
      of the facial skeleton depends upon the phylogenetically established, more or
      less evolved extensive-growth potentially of the facial nervous trunks as well.
      The growth relation existing between the developing brain and its bony case
      applies essentially even for the axial organ, the extremities as well as for the
      facial skeleton. The experimental findings speak in favour of the theoretical
      expectation that the typical teratogenic deformities of the extremities
      (micromelia), of the spine (scoliosis, defects of the vertebrae and of the ribs)
      as well as of the beak (jaws) which may be produced by a great number of most
      diverse teratogens, result from the adaptation of the bone growth to the growth
      insufficient nervous trunks, viz., from the pathologically enhanced osteo-neural
      growth disproportion. The cleft palate and the digital defects (syndactylia,
      oligodactylia) may be readily explained by the growth-inhibition of the palatal
      and digital nervous structures as well. The vertebrate body may be thus conceived
      as composed of 2 growth types, viz., the neural-extensive and the cellular
      divisional (mitotic). The former is represented by an extremely dense feltwork of
      nerve fibers and trunks (the DONALDSON'S "nervous skeleton") which is "stuffed"
      with the other, mostly mitotically growing tissues. The 2 growth types are
      closely related partly at the macro-(organ-) level concerning the normal and
      teratogenic morphogenesis of the skeleton, partly at the micro-level of the
      utmost periphery, viz., of the terminal extensive meshwork and the individual
      cells or groups of cells. The cells which escape from the extensive feltwork
      (i.e. from the "nervous skeleton") such as the superficial cells of the epidermis
      or mucous membranes and, in all probability, the elements of the haemopoetic
      organs, perish under normal conditions, suffer a planned, highly purposeful
      death. With regard to the lack of normal nerves within malignant tumours, the
      malignant cell may be conceived as the one which escaped from the limiting
      confines of the extensive feltwork and, inspite of that, continues to live
      instead of "committing suicide."

PMID- 1034577
TI  - The development of the Chondrocranium in the golden hamster, Mesocricetus auratus
      (Waterhouse).
AB  - 3 -stages of development of the chondrocranium of the golden hamster have been
      described. The chondrocrania of the gerbil, mouse and white rat have been
      compared with the chondrocranium of the golden hamster and the main differences
      noted. In several respects, the chondrocranium of the golden hamster is
      primitive.

PMID- 1034578
TI  - [Pathologic discharge from the breast. Galactography and histologic clarification
      (author's transl)].
AB  - Up until 31 December 1975, 1646 galactograms were made in 1150 female patients.
      The intentional segment resection and then the histologic preparation via
      complicated technique adapted to the excision was conducted 371 times. - In 99
      out of 100 cases, an anatomic substrate could be found for the discharge. We were
      unable to discover any pathological finding to explain the discharge in only 3
      cases (0.8%). Included in the benign processes were 170 cases of duct papillomas
      (45.8%). In these cases segment resection is also adequate therapy. -
      Approximately 8% of the excisions revealed cancer. In additional 12%, serious
      proliferative processes in the breast were found which should, at least, be kept
      under careful clinical supervision. - Galactography used in combination with an
      adapted surgical and histologic technique to diagnose not only a carcinoma which
      has evaded other methods of detection but also possible preliminary stages is a
      valuable procedure.

PMID- 1034579
TI  - [Chronic recurrent mastitis associated with galactorrhea: case report (author's
      transl)].
AB  - The problems in the pathophysiology of chronic recurrent mastitis in association
      with galactorrhea are discussed. The discussion was centered around the role of
      Prolactin. Treatment consists of inhibition of Prolactin by Bromocryptin
      following exclusion of other conditions of importance in the differential
      diagnosis.

PMID- 1034580
TI  - A developmental study of progesterone, corticosterone, cortisol, and cortisone in
      the adrenal glands of the embryonic chick.

PMID- 1034581
TI  - Identification of cortisol in plasma of the embryonic chick.

PMID- 1034582
TI  - Allosomal and autosomal control of sex ratio in PHH and PHL mice.
AB  - When male mice from inbred PHH (sex ratio .535) and PHL (.435) are mated to
      females of various inbred lines, the sex ratio follows the male parent. The sex
      ratios from litters sired by reciprocal cross F1 males (letting A represent a set
      of autosomes) are 0.510 from AH/AL, XL/YH and 0.469 from AH/AL, XH/YL. The
      difference is statistically significant but only half the difference between pure
      strains. The paternal effect, presumably due to the Y, persists in progeny of the
      two kinds of F2 males. In backcrosses to the female parent, resulting finally in
      AH/AH, XH/YL and AL/AL, XL/YH, and in outcrosses, the effect of the Y chromosome
      does not persist, indicating that neither the Y alone, nor the autosomes alone,
      will cause the sex ratio to depart significantly from equality of sexes. When
      pairs of males in all possible combinations were presented with C57BL/6 females
      mating success gave the following ranking: AH-YL, AL-YL, AH-YH, AL-YH. The
      combination of autosomes from PHH and Y-chromosome from PHL seems to confer the
      greatest competitive advantage.

PMID- 1034583
TI  - [Development of spontaneous mutations in somatic mamalian cells and DNA
      replication. II. Expression of gene mutations in cultured cells].
AB  - The dependence of spontaneous rate and phenotypic expression of 6-mercaptopurine
      resistance mutations of DNA replication synthesis was studied in cultured Chinese
      hamster cells. Spontaneous mutations arising with a constant rate per cell per
      time unit independently on DNA replication rate were shown to be expressed only
      in the course of subsequent cell divisions. The frequency of N-nitrosomethylurea
      induced mutations in cells with reduced and normal DNA replication rate is
      approximately the same. However, DNA replication synthesis is necessary for the
      phenotypic expression of both induced and spontaneous mutations. The causes of
      the phenotypic lag are discussed.

PMID- 1034584
TI  - [Use of the integral parameter of dermatoglyphic differences for determining the
      type of zygosity of twins].
AB  - A method is described increasing the reliability of twin zygosity diagnosis in
      cases when the possibility of using a large number of mendelian markers is
      restricted. The method is based on the determination of generalized index of
      dermatoglyphic differences between members of twin pair for 18 characteris of
      finger and palm dermatoglyphics and on principles of multivariate genetic
      analysis, which is worked out to determine the degree of heritability of
      multifactorial character and to study the structure of hereditary predisposition
      to multifactorial diseases. The efficiency of the method with respect to
      determinating the type of twin zygosity is approximately equivalent to the
      efficiency of using 5--6 mendelian marker systems.

PMID- 1034585
TI  - [Obstetrical problems in the adolescent female].

PMID- 1034586
TI  - [Placental hemangioma].

PMID- 1034587
TI  - [The course of labor and pregnancy in cases of twins].

PMID- 1034588
TI  - Nematodes parasitizing domestic ruminants in Afghanistan.
AB  - A total of 12 nematode species were determined in the collection recovered from
      domestic ruminants in Afghanistan. Ten of them were found for the first time in
      this region: Trichocephalus globulosus, Trichostrongylus probolurus, Cooperia
      bisonis, Nematodirus spathiger, N. abnormalis, Thelazia rhodesi, Bunostomum
      phlebotomum, Haemonchus contortus, Dictyocaulus filaria and Oesophagostomum
      radiatum. Morphological and metrical characteristics of T. globulosus, T.
      skrjabini and C. bisonis, based on our own material, are added.

PMID- 1034589
TI  - Localization of some enzymes in polycephalic larvae of two species of the genus
      Multiceps (Cestoda).
AB  - The histochemical distribution of alkaline phosphatase (AIP), acid phosphatase
      (AcP) and nonspecific esterase (NE) has been determined in polycephalic larvae of
      the species Multiceps multiceps Leske, 1870 and M. endothoracicus Kirschenblat,
      1948. In the scolex anlages of both species, an activity of these enzymes has
      been determined in sites associated with growth and with the transport of
      metabolites. In a young larva of M. multiceps, the activity of AIP, AcP and NE
      was strong in the entire proliferating bladder wall surrounding groups of
      scoleces, but absent in the remaining part of the bladder wall outside the area
      of these scolex groups. In young larvae of M. endothoracicus, AlP and NE activity
      was highest in the modified bladder wall forming a verrucose mound, and at the
      site of the opening of the invaginated canal. No activity of these enzymes was
      demonstrated in mature and aging larvae.

PMID- 1034590
TI  - Interspecific affinity among keratinolytic fungi associated with birds.
AB  - Twelve species of keratin decomposers isolated from 923 samples of feathers,
      nests and pellets of 90 species of free-living birds were clustered in 4 "econs"
      (numerical ecological groups): (A) Artroderma tuberculatum, A. ciferrii, A.
      multifidum, A. cuniculi (associated with the birds nesting in hollows); (B)
      Ctenomyces serratus, Arthroderma quadrifidum, Chrysosporium evolceanui
      (moderately alkalophilic species associated with the birds having a frequent
      contact with the soil); (C) Chrysosporium keratinophilum, Aphanoascus fulvescens,
      Chrysosporium tropicum (alkalophilic and hygrophilic species); (D) Arthroderma
      curreyi, Aphanoascus terreus (the species common in water habitats and associated
      frequently with exoanthropic birds). Two simple numerical procedures were used
      and compared: (1) Jaccard's association coefficient, and Sorensen's complete
      linkage clustering; (2) Forbes's association coeficient adjusted with chi-square,
      and the 3-linkage clustering technique. The method (2) seemed to be more
      effective.

PMID- 1034591
TI  - Notes on the distribution of Eimeria dukei Lavier, 1927 in African bats.

PMID- 1034592
TI  - [Absorption, distribution, excretion and metabolism of a basic ether compound
      (R97) with antispasmodic activity].
AB  - The absorption, distribution, excretion and metabolism of 14C labelled 2
      chlorophenyl-1-phenyl-3-(2 methyl-piperidino) propyl ether methyl iodide (14C
      R97) were studied by means of direct measurement of radioactivity and
      autoradiographic technique in rats. 1) With intravenous administration,
      radioactivity was found in all the tissues and organs immediately after dosing,
      with particularly high levels in the liver, kidney, heart and lung. Five minutes
      after administration, the level of radioactivity in blood decreased to about 6%
      of the initial level, indicating the rapid absorption of radioactive material by
      other tissues and organs. Radioactivity was not detected in the brain and eye.
      Thirty minutes after administration, the concentration of radioactivity in the
      gastrointestinal contents was very high and a certain amount of radioactivity
      uptake was noted both in gastric and intestinal mucosa. Approximately 12% and 40%
      of radioactivity administered was excreted in the urine and feces respectively
      during the first 24 hours, however, the excretion of radioactivity by expiration
      was not determined. 2) With oral administration, radioactivity was restricted to
      the gastrointestinal tract. Activities in other tissues and organs were not
      detectable. Approximately 94% of the radioactivity administered was recovered in
      feces during the first 24 hours. 3) Radioactivity was not observed in either the
      foetus or placenta after both intravenous and oral administrations. 4) The
      results from autoradiographic study were in good accord with those described
      above.

PMID- 1034593
TI  - [Effect of ursodeoxycholic acid on bile secretion and bile components. Comparison
      with chenodeoxycholic acid and dehydrocholic acid].
AB  - Effects of some bile acids on the biliary flow, BSP output and composition
      (phospholipid, cholesterol, bilirubin and bile acids) were studied in dogs.
      Ursodeoxycholic acid (UD), chenodeoxycholic acid (CD) and dehydrocholic acid (DC)
      caused a dramatic increase in biliary flow and BSP output. Relative potencies of
      these effects were DC greater than CD greater than or equal to UD. UD increased
      the phospholipid, bile acids and cholesterol concentration but had little effect
      on bilirubin concentration. Furthermore, UD greatly increased the output of four
      bile components. CD slightly decreased the phospholipid, cholesterol and
      bilirubin concentration without the bile acids, while CD increased the output of
      bile components. After UD or CD administration, the bile acid of each appeared
      markedly in the bile, dose dependently. On the other hand, DC caused a dramatic
      decrease of phospholipid, cholesterol and bilirubin concentration but had little
      effect on bile acids concentration. Output of bile components was increased by DC
      the first 1 hr but decreased at 2 hr. After DC administration, 3alpha, 7alpha
      dihydroxy-12keto-5beta-cholanic acid appeared in the bile while DC did not.
      Therefore, it is concluded that UD and CD are cholanereticas and DC is a
      hydrocholeretica.

PMID- 1034594
TI  - [Conditioning of emotional behavior caused by hypothalamic stimulation (4).
      Effects of drugs on conditioned avoidance and escape behavior].
AB  - In the present study, effects of psychotropic drugs were analyzed by observing
      avoidance and escape behavior or rabbits under hypothalamic electrical
      stimulation. In avoidance behavior, chlorpromazine (CPZ) and diazepam (DZP)
      depressed avoidance response and extended avoidance response latency and head
      movement latency. Autonomic behavior such as opening of palpebral fissure and
      pupil size were also delayed. The locus of movement and count of head movement
      were depressed by the administration of each drug. On the other hand, unlike CPZ,
      DZP extended escape response latency. On escape behavior, effects of CPZ and DZP
      were apparently different. Unlike CPZ, DZP induced avoidance behavior and
      increased locus of movement. With methamphetamine, no avoidance behavior was
      observed, but under conditional stimulation, the behavior and the escape response
      latency were decreased. Chlordiazepoxide induced avoidance behavior.

PMID- 1034595
TI  - [A shift to diurnal feeding following chronic administration of theophylline in
      rats].
AB  - Influence of chronic administration of theophylline on feeding behavior in rats
      was studied in contrast with the saline controls under a 12 hr light-dark cycle.
      The results obtained were as follows: 1) total amount of food intake per 24 hr
      was not affected by either chronic administration of theophylline or saline
      administration; 2) theophyllinized rats, however, ate more food during light time
      (0900-2100) and less food during the dark (2100-0900); 3) the amount of food
      intake during the dark in the control group was approximately 80% of total
      intake, while that in the theophylline group decreased to below 60%; 4) increase
      in ratios of body weights in the theophylline and the control groups did not
      differ significantly throughout the entire experimental period. Feeding behavior
      of the rat is closely correlated with a daily light-dark cycle as was seen in the
      control group. The feeding circadian pattern disappeared in theophyllinized rats,
      i.e., the behavioral characteristic of a nocturnal feeder could not be preserved
      following theophylline administration. The disappearance of the feeding cycle may
      result from a phase shift of the cycle, which was induced by facilitatory effects
      of theophylline on food intake during light time.

PMID- 1034596
TI  - [Conditioning of emotional behavior caused by hypothalamic stimulation (3): The
      learned behavior caused by hypothalamic stimulation in rabbits].
AB  - In the present study, the learned behavior caused by hypothalamic electrical
      stimulation was examined in order to determine the effects of psychotropic drugs.
      Subjects were albino male rabbits with electrodes chronically implanted in the
      hypothalamic area. A shuttle box, which was adjusted for behavioral
      pharmacological estimation of drugs in rabbits, was used. A buzzer sound (85dB)
      and electrical stimulation of hypothalamus (100 HZ, 1 msec, 1.2-2.0V) were used
      as the conditional stimulation (CS) and unconditional stimulation (UCS),
      respectively. The same animal was trained in habituation to a buzzer sound as the
      CS. For avoidance conditioning in a two-compartment situation, the animal was
      placed in a shuttle box divided by a hurdle situated at the middle of two
      compartments. After the CS was presented for 10 sec, the UCS was given. The
      animals were subjected to 15 conditioning trials per day. The avoidance and
      escape behavior model became as distinct by hypothalamic stimulation as by UCS.
      After termination of the experiments, extinction trials were carried out after
      which the animals were sacrificed, and localization of the stimulating electrodes
      was determined histologically.

PMID- 1034597
TI  - Prostaglandin Falpha, progesterone and oestrogens in relation to parturition in
      sheep.
AB  - Six hourly blood samples were collected from either the uterine vein or posterior
      vena cava of 8 conscious ewes over a period of about 1 week prior to and 2 days
      after parturition. In addition blood was also collected simultaneously from the
      jugular vein. Using sensitive radioimmunoassay techniques, these samples were
      analyzed for PGF2 alpha, progesterone and oestrogens. The results indicate that
      concentrations of PGF2 alpha in sheep blood started to rise before a fall in
      progesterone concentrations. A rise in total oestrogens also preceded the fall in
      progesterone concentrations. It was however not possible to show a temporal
      relationship between the rises in oesterogens and PGF2 alpha concentrations.

PMID- 1034598
TI  - [Current trend in cardiac surgery: with special reference to the problems of
      myocadial preservation during open heart surgery].

PMID- 1034599
TI  - [Behavioral construction of hypothalamic rage in cats (author's transl)].

PMID- 1034600
TI  - [Influence of amygdaloid lesions upon electrically elicited hypothalamic rage
      responses in cats (author's transl)].

PMID- 1034601
TI  - [Drying test of bile and absorptive activity of gallbladder (author's transl)].

PMID- 1034602
TI  - [Significance of biliary cholesterol and bilirubin in gallstone formation
      (author's transl)].

PMID- 1034603
TI  - [Evaluation of the use of freeze-dried homologous vein graft in peripheral
      arterial reconstruction (author's transl)].

PMID- 1034604
TI  - [Nosographic analysis of Werner's syndrome].

PMID- 1034605
TI  - [The crycoarytenoid joint in progressive polyarthritis].

PMID- 1034606
TI  - [Late manifestations of lupus erythematosus and myasthenia gravis in an 82-year
      old woman with cancer of the thymus. Metabolic reactions].

PMID- 1034607
TI  - [Severe deformities of the femur head. Radiographic and histological studies.
      Part IV].

PMID- 1034608
TI  - [Sialic acid in the synovial fluid in progressive polyarthritis, in reactive
      synovitis due to localized involvement and in post-mortem specimens].

PMID- 1034609
TI  - [Dysplasia epiphysialis multiplex. A case report].

PMID- 1034610
TI  - [Comparative studies in cholesterol metabolism in the salivary glands and the
      livers of mice (author's transl)].
AB  - The comparative radioisotopic studies in cholesterol metabolism between salivary
      glands and livers were done. 1. In the salivary glands, the cholesterol
      biosynthesis from acetate-1-14C or mevalonic acid-2-14C in vitro and in vivo, the
      elimination rate of cholesterol-4-14C and the uptake of cholesterol-4-14C
      following a single subcutaneous injection, were lowered compared with liver. 2.
      The rate of cholesterol catabolism in the salivary gland, determined by
      cholesterol-4-14C injection, were very less than in liver. 3. When the animals
      were consuming a diet labeled with cholesterol-3H of constant specific activity
      using cholesterol balance techniques, the isotopic steady state in both salivary
      gland and liver was within about 20 days and remained essentially constant
      thereafter, while specific activity of the salivary glands were remarkably lower
      than that of livers.

PMID- 1034611
TI  - [Effect of nicotinic acid derivatives on the cholesterol metabolism with special
      regard to biosynthesis, absorption and excretion of cholesterol in the salivary
      gland (author's transl)].
AB  - The cholesterol metabolism of the salivary gland of mice fed on a diet containing
      0.5% nicotinic acid derivative, 2, 2, 6, 6, tetrakis--(nicotinoyl-oxymethyl)-
      cyclohexanol (K-31) was as follows. 1. Total cholesterol level of sublingual and
      submaxially glands decreased in mice fed on normal diet as well as cholesterol
      added diet. 2. The in vivo cholesterol biosynthesis from the acetate-1-14C
      increased in the sublingual gland, while it was not affected in the submaxillary
      gland. However, in vitro cholesterol synthesis decreased in both sublingual and
      submaxillary glands. 3. The disappearance of cholesterol-4-14C injected into the
      mice was more rapid in the K-31 treated mice than in the control after 30 days.
      4. The incorporation of cholesterol-7-3h with a constant specific radioactivity
      administered orally for 37 days was reduced in the sublingual and submaxillary
      glands of K-31 treated mice. 5. When the mice were maintained on cholesterol
      added diet for 21 days after cholesterol-4-14C injection, the excretion of sterol
      14C in the feces was increased in K-31 treated mice. Thus, it was considered that
      the decrease of the cholesterol level of salivary glands by oral administration
      of K-31 is due to the increase of the excretion of cholesterol, the decrease of
      the uptake of the external cholesterol and the increase of excretion of sterol in
      the feces. These alterations of the cholesterol metabolism appear to induce
      cholesterol biosynthesis.

PMID- 1034612
TI  - [Gross and light microscopic observations of the pudendal nerve of the guinea pig
      (author's transl)].
AB  - Using thirty six adult guinea pigs, the course and distribution of the pudendal
      nerve was observed macroscopically and then the constitution of the myelinated
      nerve fibers in these branches was studied with the fan-wise split preparation
      method (Fukuyama) and the cross sections embeded in paraffin wax. The main
      findings are summarized as follows: 1) The pudendal plexus in the guinea pig is
      formed most frequently by a bigeminal nerve which arises from the ventral ramus
      of the second sacral nerve at an average rate of 55.0% and the pudendal nerve is
      so independent from the sciatic nerve that the most part of the bigeminal nerve
      runs into the pudendal nerve. 2) The perineal nerve of the guinea pig arises most
      frequently with four roots (43.3%). The myelinated fiber constitution of this
      nerve is as follows: The small-sized fibers occupy 49.8%, the medium--sized
      21.9%, the large--sized 15.1%, the maximum--sized 13.1% on an average, and the
      nerve fiber diameters observed in the cross section shows a bimodality in their
      distribution, of which the fibers in the higher peak are 1 mu to 2 mu and in the
      lower peak 5 mu to 8 mu. 3) The dorsal nerve of the penis or clitoris of the
      guinea pig arises most frequently with one root from the originating roots of the
      perineal nerve. The relationship between the sciatic and dorsal nerve appears to
      be scanty. The myelinated fibers of this nerve comprise 50.8% of small--sized,
      28.4% of medium--sized, 14.7% of large--sized and 6.2% of maximum--sized fibers
      on an average. The fiber sized histograms constructed in the cross section shows
      a unimodality laying at 1 mu to 3 mu and the dorsal nerve of the clitoris
      contains more medium fibers 3 mu to 6 mu than the perineal nerve. From these
      results, it seems clear that the genital corpuscles are supplied by these medium
      fibers. 4) The inferior rectal nerve of the guinea pig arises from the perineal
      nerve in all cases, however, it is very slender. 5) The branch to the Obturator
      internus arises from the originating root or main trunck of the perineal nerve
      (51.7%). The myelinated fiber constitution of this branch is as follows: The
      maximum--sized fibers occupy 67.6%, the large--sized 16.2%, the small--sized 9.5%
      and the medium sized 6.8%. On the other hand, the fiber diameters observed in the
      transverse section are distributed around three peaks lying at 1 mu, 8 mu to 9 mu
      and 12 mu to 13 mu. 6) The branch to the accessory head of the Semitendinosus
      arises from the pudendal nerve at an average rate of 91.7%, of which this branch
      arises most frequently with one root from the originating root of the perineal
      nerve. The myelinated fiber constitution is as follows: The maximum--sized fibers
      50.0%, the large--sized 23.9%, the small--sized 15.9% and the medium--sized 10.2%
      on an average. The histogram shows that myelinated fibers in this muscular branch
      consist of two groups of 1 mu to 2 mu and 12 mu to 14 mu...

PMID- 1034613
TI  - [Phonocardiographical studies in hypertensive subjects (author's transl)].
AB  - Phonocardiographical (PCG) studies were made to evaluate the relation of the PCG
      to blood pressure, ECG, chest X-ray finding and changes of fundi in hypertensive
      subjects. One hundred and thirty hypertensive patients and sixty normal adults
      were examined. Results were as follows: 1) There were abnormal second heart
      sounds such as, narrow splitting or ringing in most cases of hypertensive
      subjects with high both systolic and diastolic blood pressure. These phenomena
      seemed to be delay and accentuation of aortic component. 2) Ejection murmur was
      found in majority of constantly hypertensive cases. 3) The third and fourth
      sounds had no definite correlation to blood pressure. However, accentuation of
      the fourth sound was found only in subjects with severe myocardial changes in
      ECG. 4). Q-I time in hypertensive group was found to be prolonged as compared to
      normal. 5) In normal subjects, I-IIA interval was related closely to square root
      R--R. It was not clear in hypertensive group, and the most cases of this group
      showed that I-IIA interval was prolonged as compared to square root R--R.
      Prolonged I-IIA interval was seen in the group with only high voltage and no
      myocardial abnormality in ECG. In conclusion, characteristic phonocardiographical
      findings in hypertensive subjects were the prolonged mechanical contraction time
      involving isovolumic one and this time became shorter when myocardial damage was
      increased in its severity.

PMID- 1034614
TI  - [Electron microscopic studies of lymphocytes in the bone marrow of the mouse. I.
      Effect of hydrocortisone on marrow small lymphocytes (author's transl)].
AB  - In male dd-mice given two subcutaneous injections of 0.5 mg of hydrocortisone at
      35 and 36 days of age, lymphocytes in the bone marrow were studied qualitatively
      and quantitatively by electron microscopy. In normal 35-day-old mice, lymphocytes
      comprise 16.4% of nucleated free cells of the marrow. Marrow lymphocytes were,
      for the most part, of small type which constituted 15.5% of nucleated marrow
      cells. Small lymphocytes consisted of two types; dark and light small
      lymphocytes. At 35 days of age, dark small lymphocytes constituted 94.4% of all
      the marrow small lymphocytes and light small lymphocytes were the remaining 5.6%.
      After administration of hydrocortisone, lymphocytes in the marrow decreased
      markedly. The proportion of lymphocytes failed to 6.1% at 1 day, 4.5% at 5 days
      and 3.5% at 10 days after injection. Thereafter it slightly increased to 5.0% at
      20 days after injection. The percentage of marrow lymphocytes at 20 days after
      injection was almost the same as that of controls at 60 days of age. Of the two
      types of marrow small lymphocytes dark small lymphocytes decreased rapidly after
      administration of hydrocortisone. They found 22.4% of the marrow small
      lymphocytes at 1 day and 10.7% at 5 days after injection. Thereafter, they
      increased gradually and occupied 58.0% of marrow small lymphocytes at 20 days. On
      the other hand, light small lymphocytes appeared more resistant to hydrocortisone
      than dark small lymphocytes.

PMID- 1034615
TI  - Separation and estimation of short-chain fatty acids and organic acids by
      thermodetective liquid chromatography.
AB  - Short-chain fatty acids and organic acids in aqueous solution were separated
      quantitatively by using a liquid chromatography. JLC-2A, which posseses a
      thermodetector with ion-exchange resin. A peak height of thermogram showing a
      thermal difference caused by adsorption and desorption of substance was
      proportional to the concentration. Each sample was detectable at least between
      approximately 10(-5) and 2 X 10(-3) moles. The "inter-day" coefficient of
      variation obtained from two peak heights of acetic and n-butyric acids was 1.9
      and 2.3%, respectively.

PMID- 1034616
TI  - [Statistical findings and patient management during the past 8 years and 6 months
      since the establishment of anesthetic rooms].

PMID- 1034617
TI  - Cytotoxicity of cysteine in culture media.
AB  - When added to Eagle's Minimum Essential Medium supplemented with 10% bovine serum
      (MEM-10BS), 1mM cysteine was highly toxic to cultured cells. This toxicity was
      eliminated by (a) preincubation of the medium at 37 degrees C for 24 hr before
      use, or (b) presence of 5mM pyruvate. Similar results were obtained with freshly
      prepared CMRL 1066 supplemented with 10% bovine serum (CMRL-10BS), which contains
      1.5 mM cysteine as an original ingredient. Medium L 15 supplemented with 10%
      bovine serum (L-10BS), which contains both 1 mM cysteine and 5 mM pyruvate,
      supported cell growth. On incubation of MEM-10BS supplemented with 1 mM cysteine
      (MEM-10BS-1CySH) or CMRL-10BS without cells for one day, the cysteine
      concentrations decreased to about one-tenth or less of the original
      concentrations. The cysteine concentration in L-10BS did not decrease so much on
      similar incubation. Pyruvate reduced the rate of disappearance of the cysteine in
      MEM-10BS-1CySH or CMRL-10BS as assayed with p-chloromercuribenzoate, although
      less than that in L-10BS. This effect of pyruvate was concentration dependent.
      These paradoxical effects of pyruvate on cysteine, i.e. the reduction of its
      cytotoxicity and the stabilization as an SH compound, are probably due to the
      formation of a dissociable complex between these two compounds, which is not
      cytotoxic and resistant to oxidation.

PMID- 1034618
TI  - Spread and control of mycoplasmal infection of cell cultures.
AB  - Environmental sampling was performed during trypsinization and passage of 3T-6
      cell cultures that contained a mean of 4.3 X 10(7) colony forming units (CFU) per
      ml supernatant of A. laidlawii. The lip of the culture flask and the outside of
      the used pipet were always heavily contaminated. The outside of the culture flask
      (3/7), the work surface (8/12) and the outside of a pan of disinfectant (4/5)
      were regularly contaminated with mycoplasmas. Airborne mycoplasmas were detected
      eight of 32 times (25%) by settling plates; simultaneous forced-air samplers by
      two different methods were always negative. The technician's hands were
      contaminated two of 15 samples. When hands were contaminated, more contamination
      was detected in the environment. Droplets of A. laidlawii and M. orale inoculated
      onto work surfaces survived drying for a minimum of 3 days, even in laminar
      airflow cabinets. Twenty-five of 31 (80.6%) cell culture technicians carried M.
      salivarium in their throats; only two carried M. orale. It is concluded that
      mycoplasma-infected clltures are the most common source of further infection.
      Recommendations for prevention and control of mycoplasmal infection are listed.

PMID- 1034619
TI  - Immobilization of testicular hyaluronidase using concanavalin A.

PMID- 1034620
TI  - Organ  culture -- a system for rapid carcinogenicity screening of tobacco
      extracts on oral mucosa.

PMID- 1034621
TI  - Cardiocirculatory and biochemical effects of dextran 1.8% and ringer's lactate
      after minor surgical procedures.
AB  - The effects of dextran 1.8% in Ringer's lactate solution were compared with
      infusion of Ringer's lactate alone in two groups of 12 patients after minor
      surgical interventions. Plasma volume increased significantly only in the dextran
      treatment patients. We observed a marked hemodilution with both infusions, but
      all changes had disappeared after 24 hours. No adverse effects on the coagulation
      process, hepatic and renal function were noted. These results suggest that
      dextran 1.8% in Ringer's lactate is an effective and safe solution in plasma
      volume expansion for this type of patient.

PMID- 1034622
TI  - [Hypoproteinemia--consequence of cause of diseases, particularly in long-term
      hospitalized patients].
AB  - In most cases hypoproteinemia of our patients is a result of the disease leading
      to hospitalization. Moreover, it may also be a consequence of unappropriate
      nutrition, so that it has to be pointed out with emphasis that clinics being able
      to furnish a great number of ferment analysis should be in a position to answer
      the simple question: are patients receiving adequate nutrition or not? Necessary
      assumption for this purpose is-besides analyses of serum-protein-in acute cases
      the control of nitrogen excretion in urine and in case of exact balances also in
      stool, in order to exactly answer the question, whether the nitrogen supply will
      suffice special requirements.

PMID- 1034623
TI  - [Dietetic and antibiotic preparation in surgery of the large intestine].
AB  - Besides patient's cardiac, pulmonary, renal and hepatic status, a correct
      operative technique and mechanical bowel cleansing the protein status is of
      central importance to prevent anastomotic leakage and wound infection in colon
      surgery. Using an oral elemental diet prior to surgery both sufficient caloric
      and protein intake and reduction of intestinal flora can be achieved. Wound
      infection and anastomotic leakage are reduced significantly without the side
      effects of antibiotic bowel preparation. If oral antibiotics are used
      preoperatively only a short term low dose regimen is effective for the control of
      infection after colon surgery which reduces the concentration of aerobes and
      anaerobes.

PMID- 1034624
TI  - [Faulty nutrition in gastrointestinal diseases].

PMID- 1034625
TI  - Cuticle formation in parasitic nematodes: RNA biosynthesis and control of
      molting.

PMID- 1034626
TI  - Oncospheral hook morphogenesis in the davaineid cestode Inermicapsifer
      madagascariensis (Davaine, 1870) Baer, 1956.

PMID- 1034627
TI  - Retrograde urethrogram: a new technic.

PMID- 1034628
TI  - The postnatal development of the alimentary canal in the opossum. II. Stomach.
AB  - The postnatal development of the gastric mucosa in the opossum has been traced
      with the light, transmission and scanning electron microscopes. The formation of
      fovea and gastric glands occurs simultaneously during the postnatal period.
      During the first 60 postnatal days the developing gastric glands are composed of
      undifferentiated cells, parietal cells and scattered endocrine cells. Chief cells
      are not present until just before weaning (13 cm, i.e. ca. 75 days). Juvenile and
      adult animals show only a small population of chief cells, and these are confined
      to the bases of the gastric glands. The pH of stomach contents ranges from 6-0 to
      6-5 until the time of appearance of solid food within the stomach, when it drops
      to 2-0-2-5. The surface cells lining the gastric lumen contain a considerable
      amount of what appears to be lipid during the first 3 weeks after birth, and this
      may indicate that the gastric mucosa is involved in the absorption of lipid
      during this period. The mode of lipid absorption appears to be different from
      that described for the intestinal tract of several other species.

PMID- 1034629
TI  - RIT 2214, a new biosynthetic penicillin produced by a mutant of Cephalosporium
      acremonium.
AB  - A number of lysine-requiring auxotrophs of Cephalosporium acremonium were
      investigated for incorporation of side-chain precursors and for accumulation of
      beta-lactam compounds. One of the auxotrophs, Acremonium chrysogenum ATCC 20389,
      producing cephalosporin C and penicillin N only if grown in media supplemented
      with DL-alpha-amino-adipic acid (DL-alpha-AAA), was found to use L-S
      carboxymethylcysteine (L-CMC) as a side-chain precursor for the synthesis of a
      new penicillin (RIT 2214). No corresponding cephalosporin was detected. The
      penicillin present in the culture filtrate, was concentrated by adsorption on
      activated carbon and successive column chromatography on Amberlite IRA-68 and
      Amberlite XAD-4. Final purification was achieved by cellulose column
      chromatography. RIT 2214 was identified as 6-(D)-[(2-amino-2-carboxy)-ethylthio]
      acetamido]-penicillanic acid by spectral analysis, bioactivity spectrum,
      elucidation of side-chain structure and finally by semisynthesis. Its biological
      properties were also evaluated.

PMID- 1034630
TI  - Profile of cerebrovascular accidents in the young.

PMID- 1034631
TI  - A cytoplasmic inhibitor of DNA polymerase from the plasmodia of Physarum
      polycephalum.
AB  - A factor which inhibited DNA polymerase [EC 2.7.7.7] activity was isolated from
      the cytoplasm of plasmodia of true slime mold, Physarum polycephalum. This factor
      was purified by DEAE-Sephadex and CM-cellulose column chromatographies, heat
      treatment and gel filtration. This inhibitor was heat-stable, insensitive to
      trypsin [EC 3.4.21.4] and was not digested by RNase [EC 3.1.4.22] or DNase [EC
      3.1.4.5]. The molecular weight was 16,000 as determined by gel filtration, and
      the isoelectric point was determined to be pH 10.1. In the presence of the
      inhibitor, Km for DNA in the DNA polymerizing reaction was markedly increased.
      The inhibitory effect was eliminated by addition of excess DNA, but the addition
      of excess enzyme or deoxyribonucleoside triphosphates had no effect on the
      inhibition.

PMID- 1034632
TI  - The H+/site ratio of mitochondrial electron transport.
AB  - The number of H+ ejected during passage of 2e- through each energy-conserving
      site of the mitochondrial respiratory chain (the H+/site ratio) was measured in
      three ways. In each case transmembrane movements of endogenous phosphate were
      minimized. (1) Measurement of the uptake of weak acids during loading of
      mitochondria with Ca2+ demonstrated that 2.0 weak acid anions were accumulated
      per Ca2+ ion. Since 1.7 to 2.0 Ca2+ ions were were taken up per site, these data
      correspond to an H+/site ratio of 3.5 to 4.0. (2) More direct measurement of H+
      ejection using the oxygen pulse technique demonstrated that the H+/site ratio was
      3.0. In these experiments phosphate movements were prevented by addition of N
      ethylmaleimide to inhibit phosphate-hydroxide antiport, by washing the
      mitochondria to remove endogenous phosphate, or by working at 5 degrees C to
      reduce the rate of phosphate transport. When phosphate movements were allowed,
      H+/site ratios of 2.0 were observed. (3) Measurement of the initial steady rates
      of oxygen consumption and H+ ejection following addition of substrate to aerobic,
      substrate-limited mitochondria yielded H+/site ratios of 2.0, which were elevated
      to 4.0 when phosphate transport was prevented as described above. Previous
      determinations of the H+/site ratio were thus underestimates due to the
      unrecognized movements of endogenous phosphate; our results show that the H+/site
      ratio is at least 3.0 andmay be as high as 4.0.

PMID- 1034633
TI  - Magnesium deprivation reproduces the coordinate effects of serum removal or
      cortisol addition on transport and metabolism in chick embryo fibroblasts.
AB  - A variety of unrelated effectors stimulate or inhibit coordinately the same array
      of metabolic reactions in chick embryo fibroblasts, including the uptake of 2
      deoxy-D-glucose and uridine, and the incorporation of uridine and thymidine into
      acid insoluble material. The coordinate inhibition of these reactions by omission
      of serum or addition of cortisol is reproduced quantitatively by lowering the
      concentration of magnesium (Mg2+) in medium containing 0.2 mM Ca2+. The response
      times for the utilization of uridine and thymidine following the removal of
      addition of Mg2+ are similar to those which follow removal or addition of serum.
      The effect of serum on the incorporation of choline, which is not part of the
      coordinate response to unrelated effectors, is not reproduced by varying Mg2+
      concentrations. The results support the hypothesis that the availability of Mg2+
      within the cell plays a central role in the coordinate control of transport,
      metabolism and growth by external physiological effectors.

PMID- 1034634
TI  - Stimulation of sugar uptake in cultured fibroblasts by epidermal growth factor
      (EGF) and EGF-binding arginine esterase.
AB  - Mouse epidermal growth factor causes a rapid increase in 2-deoxyglucose uptake in
      stationary phase mouse (3T3) cells or human fibroblasts. Maximum effect is
      approximately two fold over control levels for 3T3 cells and about 50% over
      controls for human fibroblasts. Maximum effect on 3T3 cells is seen about two
      hours after addition of 10 ng/ml EGF to the culture medium. Stimulation is easily
      measureable within the first fifteen minutes after addition of the hormone and
      may be detected at hormone concentrations as low as 0.1 ng/ml. The EGF-binding
      arginine esterase found associated with EGF in the mouse submaxillary gland
      causes an enhancement of the EGF effect. In serum-free medium, the EGF effect is
      still readily observed, but no enhancement by the esterase is seen. SV40 virus
      transformed 3T3 cells show no effect on deoxyglucose uptake after addition of 10
      ng/ml EGF to the culture medium, but a response may be demonstrated after these
      cells are incubated for 12 hours or more in serumless medium. EFG stimulates
      transport of 3-O-methylglucose in stationary phase 3T3 and human fibroblasts but
      no EGF stimulation of alpha-amino-isobutyrate uptake in 3T3 cells is seen under
      conditions is reproted to inhibit intracellular degradation of human EGF by human
      fibroblasts, does not diminish the EGF effect on deoxyglucose uptake in human
      fibroblasts.

PMID- 1034635
TI  - Current status of the thiol redox model for the regulation of hexose transport by
      insulin.
AB  - Data obtained over the last two years pertinent to the thiol redox model for the
      modulation of hexose transport activity by insulin is summarized. The model
      proposes that activation of hexose transport in fat cells involves sulfhydryl
      oxidation to the disulfide form in a key protein component of the fat cell
      surface membrane. Theoretically, the rapid activation of transport by insulin may
      involve either the conversion of inactive membrane carriers to the active form as
      originally proposed, or the conversion of a low Vmax transport system to a high
      Vmax form. The present experiments showed that the percent inhibition of insulin
      activated transport rates by submaximal levels of cytochalasin B was decreased
      compared to its effects on basal transport. Treatment of fat cells with N
      ethylmaleimide inhibited cytochalasin B action but not transport activity. When
      insulin or the oxidant vitamin K5 was added to cells 5 minutes before the N
      ethylmaleimide, the elevated transport activity was also resistant to the
      sulfhydryl reagent, but cytochalasin B retained its potent inhibitory effect on
      transport. The data demonstrate that unique properties characterize basal versus
      insulin-activated transport activity with respect to the sensitivity of
      cytochalasin B action to sulfhydryl blockade in isolated fat cells. The data are
      consistent with the concept that activation of transport activity reflects the
      conversion of a reduced (sulfhydryl) system characterized by a low Vmax to an
      oxidized (disulfide), high Vmax transport system.

PMID- 1034636
TI  - Regulation of glucose transport in chick fibroblasts: bicarbonate, lactate and
      ascorbic acid.
AB  - The rate at which chick embryo fibroblasts in primary or secondary culture
      transport glucose or 3-O-methyl glucose is strongly influenced by the presence of
      bicarbonate ion in the culture medium. Cells growing or maintained on glucose at
      physiologic concentration (5.5 mM) have an 8 to 10 fold higher rate of glucose
      uptake than their counterparts cultivated without bicarbonate. These cells also
      produce more lactate as a consequence of their more rapid intake of glucose. The
      hydrogen acceptors, methylene blue and dehydroascorbate added to the culture
      medium reduce the cell capacity to transport glucose and 3-O-methyl glucose to
      levels obtaining in the bicarbonate-free medium. There is a concomitant reduction
      in glucose utilized by cells during 24 hours and further reduction in lactate
      formed per molecule of glucose metabolized.

PMID- 1034637
TI  - Comment on comparing the membrane transport properties of "normal" and
      "transformed" BALB/3T3 cells.

PMID- 1034638
TI  - Cooperative binding of concanavalin A to thymocyte membrane vesicles augments
      uptake of alpha aminoisobutyrate.
AB  - (1) Membrane vesicles from rabbit thymocytes accumulate alpha-aminoisobutyrate in
      the presence of 0.1 M NaCl. Uptake is 1/2 maximal after about 2 min and reaches a
      plateau value (61 pmoles/mg protein) after 30 min. (2) Up to 25 mug concanavalin
      A/ml, binding of the lectin describes a sigmoid curve indicative of a cooperative
      process. (3) At lectin concentrations up to 8 mug/ml, lectin binding enhances the
      uptake of alpha-aminoisobutyrate (maximally 30%).

PMID- 1034639
TI  - Uptake of amino acids in reconstituted vesicles derived from plasma membranes of
      Ehrlich ascites cells.
AB  - To obtain a clearer concept of the mechanism of organic solute transport in
      mammalian cells, we have attempted to reconstitute a functional transport system
      for amino acids from plasma membranes of Ehrlich ascites cells. Purified plasma
      membranes were dissolved in 2% Na cholate--4 M urea, a mixture which brought over
      85% of the membrane proteins into solution. After centrifugation of the
      solubilized material for 2 hrs at 100,000 x g, the supernatant was dialyzed in
      the cold for 20 hrs with additional lipid. The reformed vesicles were tested for
      the ability to transport amino acids. The preliminary results obtained show that
      the uptake of alpha-aminoisobutyric acid can be inhibited by L-methionine and
      much less by L-leucine as would be predicted from the known properties of alpha
      aminoisobutyric transport in the intact cells. In addition, it has been possible
      to show accelerated efflux of intravesicular phenylalanine when phenylalanine is
      added to the trans side (medium side). The data are consistent with the
      conclusion that there is carrier mediated transport in the reconstituted
      vesicles.

PMID- 1034640
TI  - The mechanism of interaction between high-affinity probes and the uridine
      transport system of mammalian cells.
AB  - The carrier of uridine transport in hamster cells in culture is highly
      susceptible to the inhibitory effect of probes like S-benzylated derivatives of
      mercaptopurine nucleosides. The interaction between the probes and the carrier is
      competitive and reversible and it takes place at a site different from the
      substrate binding site. The Ki for the most potent derivative p-nitrobenzyl-6
      mercaptoinosine is 0.15 n Molar at 20 degrees C. The effect of the probes is
      interpreted in terms of conformational change induced on the carrier upon binding
      of the probe. The carrier assumes distinct conformations depending on whether it
      is probe-free (form A) or probe bound (form B). Kinetic as well as chemical
      evidence supports the predictions of the allosteric carrier model. A single
      component of kinetics is observed either in the absence of inhibitor (Km form A)
      or at high concentrations of inhibitor (Km form B). A two component kinetics is
      observed at intermediate concentrations of inhibitor (some carriers in form B and
      others in form A). The two forms have distinct Km values for uridine: form A50
      muMolar and form B 250 muMolar. Two forms have also different susceptibilities to
      the action of organomercurials: form A is insensitive whereas form B is highly
      inhibited by the chemical modified of SH groups. The existence of putative
      allosteric sites in carriers is discussed in terms of modifier sites capable of
      modulating transport activities as a result of specific membrane-ligand
      interactions.

PMID- 1034641
TI  - Studies in terpenoid biosynthesis. Part 18. Biosynthesis of culmorin.

PMID- 1034642
TI  - The carbon-13 nuclear magnetic resonance spectra of flavonoids and related
      compounds.

PMID- 1034643
TI  - Synthetic and biosynthetic studies of porphyrins. Part 1. Synthesis of the "S
      411" porphyrin obtained from meconium.

PMID- 1034644
TI  - Synthetic and biosynthetic studies of porphyrins. Part 2. Synthesis of isopempto-
      and isochlorocruoro-porphyrins.

PMID- 1034645
TI  - Neighbouring group participation in the cleavage of some steroidal acetoxy
      epoxides.

PMID- 1034646
TI  - Prostaglandins. Part 4. Synthesis of (+/-)-11-deoxyprostaglandins from 2-(omega
      hydroxyheptyl)cyclopent-2-enones.

PMID- 1034647
TI  - Thermal rearrangement of 2,2,4,4-tetramethylthietan-3-one 1-oxide; a reaction
      related to the ring expansion of the penicillin S-oxides.

PMID- 1034648
TI  - 4,6,7-Trimethoxy-5-methylchromen-2-one, a new coumarin from Leonotis
      nepetaefolia.

PMID- 1034649
TI  - Ultrasonic propagation properties of mammalian testes.

PMID- 1034650
TI  - Gastro-intestinal nematodes of elite show dogs in Great Britain.

PMID- 1034651
TI  - On a new nematode Leipernema leiperi n.g., n.sp. (Strongyloididae), parasitic in
      the pangolin Manis pentadactyla from Hyderabad, India.
AB  - Leipernema leiperi n.g., n.sp. is described from the pangolin Manis pentadactyla
      in India. Both parasitic free-living generations have been examined. Features
      which differentiate the parasite from Strongyloides and Parastrongyloides are
      described.

PMID- 1034653
TI  - Stability of resistance to neguvon in the fly Musca domestica L. after cessation
      of laboratory selection.
AB  - Stability of resistance to neguvon was studied in three strains of Musca
      domestica L. after selection using different numbers of generations and different
      degrees of resistance. It has been found that the stability of resistance to
      neguvon is not always the same after cessation of selection. The loss of
      resistance depends on the duration of selection, i.e., on the degree of
      homogenization of populations with respect to resistant specimens. The degree of
      resistance is the function of the duration of selection to the same extent as the
      loss of resistance depends on it. The period of time during which the insecticide
      has been used is of decisive importance for the stability of resistance. The
      process of loss of resistance, similarly to that of its development, takes its
      course according to a zigzag curve, but in the opposite direction. This variation
      of resistance, occurring also in its development, can be explained by the
      heterogenity of the strains.

PMID- 1034654
TI  - Residual disinfection of some preparations and substances.
AB  - The results of our experiments over many years point to the possibility of
      practical application of disinfectants of residual effect. In our opinion,
      further investigations should be carried out in the following two directions:
      detection of new means and preparations showing uniform properties and
      development of an optimum method of their application. We believe that residual
      disinfection will play a role in the prophylaxis of hospitalism.

PMID- 1034655
TI  - Genus Microsporum dermatophytes in Eastern Bohemia.
AB  - The authors presented a taxonomic survey of dermatophytes of the genus
      Microsporum. From the 19 species described so far, they isolated ten species in
      the region of Eastern Bohemia. Only the species Microsporum cookei and M. gypsem
      are considered to be endemic species. The remaining are regarded as imported
      dermatophytes which are not able to maintain their existence permanently in the
      conditions of the mentioned region. Data on the findings of the individual
      species were completed by the authors' remarks on their primary hosts and/or
      substrates of heterotrophy, frequency of occurrence and geographical
      distribution.

PMID- 1034656
TI  - Taxonomy of the family Vibrionaceae considered with respect to data on the
      primary structure of deoxyribonucleic acid.

PMID- 1034657
TI  - Human infections caused by V. parahaemolyticus in Czechoslovakia.
AB  - Vibrio parahaemolyticus was isolated in two subjects with acute gastroenteritis.
      The patients' history included stay in Pakistan or India. They probably
      contracted the infection on board an aeroplane where they ingested cold meal
      containing sea products. The possibility of this conditioned pathogen occurring
      also in an inland country is pointed out.

PMID- 1034658
TI  - Nephelometric density adjustment of leptospiral antigen.
AB  - In testing leptospirosis by microagglutination, reproducibility of the results is
      affected by population age and germ concentration. These undersirable factors can
      be avoided if antibody identification is made with cultures incubated for 7 to 21
      days and adjusted to 50 X 10(6) leptospires per millilitre. Most suitable for the
      purpose is an analogue mode based on nephelometry and the probability theory. The
      obtained statistical data furnish calculated and tabulated apparatus values which
      are used for standardizing with the aid of a newly developed nepheloflask with
      compression-spring stirrer.

PMID- 1034659
TI  - [Application of mass spectrometry tp biochemistry; with special reference to CI
      MS].

PMID- 1034660
TI  - [PHB (poly-beta-hydroxybutyrate) metabolism of Zoogloea ramigera].

PMID- 1034661
TI  - [Endo-glycosidases].

PMID- 1034662
TI  - Diurnal variation and the episodic release of plasma gonadotrophins in Japanese
      quail during a photoperiodically induced gonadal cycle.
AB  - Blood samples were taken every 3 h, over a 27 h period, from (1) a group of 12
      intact male quail on short days (lights on 09.00-17.00 h) and during the 2nd,
      15th and 36th day of photostimulation (lights on 09.00-05.00 h); (2) 12 castrated
      male quail on the 2nd, 20th and 43rd long day, and (3) 12 intact male quail on
      the 12th long day. Plasma LH was measured in all samples and FSH in the 43rd long
      day castrate and 12th long day intact male samples. Although there was
      considerable variation in the levels of LH and FSH, both between birds and
      between samples taken from the same bird, statistical analyses failed to reveal
      any diurnal (or circadian) rhythm at any time. There was a marked correlation
      between the LH and FSH levels in all samples. Possible episodic LH secretion was
      investigated by taking blood samples every 15 min for between 3 and 6 h from six
      intact male quail and six laying females on long days. Samples were obtained from
      each bird at three time-periods which were arranged so as to overlap and cover
      the first 12 h of the daily photoperiod. Statistical analysis suggested that
      episodes of secretion occurred 6-10 times/day in males, and 4-8 times/day in
      females. The pulses appeared to occur at random.

PMID- 1034663
TI  - Influence of 16-aryloxyprostaglandins on the production of progesterone by human
      granulosa cells in vitro.
AB  - 16-Aryloxy analogues of prostaglandin F2alpha (PGF2alpha) are potent luteolysins
      in laboratory and farm animals. When their effect on progesterone production by
      luteinized human granulosa cells in tissue culture was investigated inhibition of
      both basal gonadotrophin-stimulated progesterone production was observed, so
      revealing characteristics expected of potential human luteolysins. The analogues
      were, however, unable to inhibit progesterone production stimulated by PGE2,
      suggesting that like PGF2alpha these compounds may act by specifically blocking
      LH-activated adenylate cyclase. The 16-aryloxyprostaglandins similarly inhibited
      progesterone production by porcine granulosa cells, so that the effects observed
      with the 16-aryloxyprostaglandins in vitro may be indicative of their potential
      in vivo.

PMID- 1034664
TI  - Surviving trophoblastic giant cells and ovarian function after prostaglandin
      induced abortion in the golden hamster.

PMID- 1034665
TI  - Diurnal variation in the activity of hepatic glycerol-3-phosphate acyltransferase
      in response to ovine prolactin in goldfish, Carassius auratus L.

PMID- 1034666
TI  - Direct exposure of postimplantation mouse embryos to 5-bromodeoxyuridine in vitro
      and its effect on subsequent chondrogenesis in the limbs.
AB  - As maternally administered 5-bromodeoxyuridine (BudR) is very quickly degraded by
      the liver, a combination of whole embryo culture and organ culture techniques was
      adopted to expose postimplantation mouse embryos to the analog and to study the
      effects of long-term embryos were exposed to increasing concentrations of BudR
      for 12 or 24 h. Forelimbs of the treated embryos were then organ-cultured in drug
      free medium and the extent of cartilage development in the explants examined.
      Exposure of embryos to 50-150 mug/ml of BudR for 24 h resulted in significant
      inhibition of chondrogenesis in the subsequent limb cultures and the effect was
      related to dose. After treatment with 150 mug/ml of the drug, the forelimbs of
      the early 11-day embryos (somite stage 26-29) showed an almost complete lack of
      cartilage, while the limbs of mid-11 th-day embryos (somite stage 32-34) were not
      nearly as sensitive and exhibited about 50% reduction in the amount of cartilage
      development. We conclude that if embryos in which the limb development is at a
      very early stage of development are exposed to BudR, the future course of limb
      differentiation is permanently and irreversibly damaged, resulting in a partial
      or even complete suppression of chondrogenesis in the organ. As both the dose and
      perhaps also the duration of treatment were critical, we suggest that the rather
      low frequency of reported limb malformations after in vivo injection of
      teratological doses of BudR may be due to only a small amount of the chemical
      reaching the embryos.

PMID- 1034667
TI  - Cell patterning in migrating slugs of Dictyostelium discoideum.
AB  - When front quarters of migrating slugs of Dictyostelium discoideum are isolated
      by surgery and induced to friut immediately they produce fruiting bodies with
      disproportionately large stalks (Raper, 1940). The data in this communication
      show that the 'stalky' character of fruits derived from front quarters persists
      even if the cells of the front quarter are disaggregated and hence to reaggregate
      before fruiting. The data also demonstrate that friuts derived from rear quarters
      of slugs have disproportionately large spore heads, and that this effect becomes
      more pronounced with increasing age of the slugs. These observations support the
      view that the cells of the front and rear of migrating slugs are to some extent
      committed to different fates.

PMID- 1034668
TI  - [Enzyme activities in serum of rabbits and rats-reference values and circadian
      alterations. Serum enzymes and factors that influence their activity,I (AUTHOR'S
      TRANSL)].
AB  - The activities of aspartate transminase (EC 2.6.1.1), alanine transminase (EC
      2.6.1.2), alkaline phosphatase (EC 3.1.3.1), acid phosphatase (EC 3.1.3.2)
      leucine arylamidase (EC 3.4.1.1), aldolase (EC 4.1.2), lactate dehydrogenase (EC
      1.1.1.27), malate dehydrogenase (EC 1.1.1.38) and cholinesterase (EC 3.1.1.7)
      were measured in serum of male rabbits and albino Wistar rats in dlplicate by
      means of microliter techniques. Furthermore, the diurnal alterations of enzyme
      activity were established in 8--10 animals of both species. Aspartate
      transaminase activity in the serum of rats was found to be significantly higher
      than in the serum of humans and rabbits, and essentially lower alkaline
      phosphatase values were obtained from the serum of rabbits in comparison with
      those found for the serum of humans and rats. Relatively high acid phosphatase
      and aldolase values as well as a very low cholinesterase activity were found in
      the serum of rabbits and rats. The mean malate dehydrogenase-activity was found
      to be twice as high as the mean lactate dehydrogenase, which is the contrary of
      the situation found in human serum. No significant diural alterations of the
      examined enzyme activities were established. The differences found between the
      animal and the human enzyme activities in serum are explained by species
      determined peculiarities of metabolism or specific enzyme configuration.

PMID- 1034669
TI  - Nuclei, septation, branching and growth of Geotrichum candidum.
AB  - A study was made of growth, septation and branching in Geotrichum candidum, a
      mould which forms physiologically complete septa. A correlation was observed
      between septation and branch initiation; branches were almost invariably formed
      just behind septa. Primary branches and their parent intercalary compartments
      initially increased in length at an exponential rate before eventually attaining
      a constant rate of extension. The whole branching system (which eventually
      contained seven tips) produced by an intercalary compartment increased in length
      exponentially until it attained a total length of at least 1-5 mm. The total
      length and the number of nuclei of undifferentiated mycelia increased
      exponentially at the same specific growth rate. The results suggest that nuclei
      divide just before or just after arthrospore formation.

PMID- 1034670
TI  - The relationship between the uptake of glucose and 3-O-methylglucose and soluble
      carbohydrate and polysaccharide in the fungus Dendryphiella salina.
AB  - When mycelium of Dendryphiella salina, pre-incubated in D-[I-14C]mannitol such
      that this is the only major labelled soluble carbohydrate present, absorbs
      glucose or the non-metabolized sugar 3-O-methylglucose, there is a specific
      stimulation of incorporation of 14C into alkali-insoluble, trichloroacetic-acid
      soluble (1 leads to 4)-alpha-glucan, probably glycogen. There is also a net
      increase in the amount of glucan caused by stimulation of synthesis and
      inhibition of breakdown. Addition of 3-O-methylglucose results in the loss of
      mannitol into the medium. This loss and the reduced rate of replenishment from
      the glucan is important in the osmotic regulation of the hyphae. If osmotic
      adjustment does not occur, the hyphae do not show the specific incorporation of
      14C into the glucan.

PMID- 1034671
TI  - A chemically-defined medium for the growth of a ureolytic strain of Streptococcus
      faecium.
AB  - A chemically-defined medium was developed which supported growth of Streptococcus
      faecium and permitted synthesis of urease. This streptococcus cannot utilize
      ammonia and needs a complex medium, but its requirements are probably provided in
      the rumen. The specific activity of urease was inversely related to growth and in
      no medium was there high growth and high urease activity. Anaerobic culture and
      the presence of urea in the medium were essential for urease activity, but not
      for growth.

PMID- 1034672
TI  - Occurrence of familial spastic paraplegia in only one of monozygous twins.
AB  - Three patients who suffer from spastic paraplegia are described who belong to two
      generations in one family. One of the patients, who has had symptoms and signs
      for at least 10 years, has a monozygous twin who is unaffected. Using blood
      groups and chromosomal polymorphisms, the probability of monozygosity is
      estimated to be 0.99986. The observation of nonpenetrance in familial spastic
      paraplegia suggests that environmental factors may be involved in provocation and
      emphasises the need for careful genetic counselling in this and related diseases.

PMID- 1034673
TI  - Isolation of 4-ribitylamino-5-amino-2,6-dihydroxypyrimidine from a high
      flavinogenic mold Eremothecium ashbyii1.
AB  - The addition of glyoxal, a trapping agent, caused simultaneously the accumulation
      of a green fluorescent compound and the inhibition of riboflavin formation in non
      growing cells of Eremothecium ashbyii. The fluorescent compound purified was
      identified as 8-ribityllumazine from the results of spectrophotometric and
      fluorometric analyses. Accordingly, the fragment, except for the glyoxal portion
      on the 8-ribityllumazine molecule, 4-ribitylamino-5-amino-2,6
      dihydroxypyrimidine, is believed to be an intermediate in the riboflavin
      biosynthetic pathway.

PMID- 1034674
TI  - Identification of the second product of the riboflavin synthetase reaction.
AB  - This study was concerned with the detailed identification of the second product
      involved in the riboflavin synthetase reaction with riboflavin synthetase from
      Eremothecium ashbyii and a trapping agent, glyoxal.Thus, a green fluorescent
      compound accumulated during the incubation. The compound was purified through
      various column chromatography steps, and was examined by UV, IR, excitation and
      emission spectra and paper chromatography to prove that the isolated compound was
      8-ribityllumazine. Accordingly it was concluded that a second product in
      riboflavin synthetase reaction was 4-ribitylamino-5-amino-2,6
      dihydroxypyrimidine, the fragment, except for C-6 and C-7 of 8-ribityllumazine,
      being an incorporated glyoxal portion.

PMID- 1034675
TI  - [Brain stem responses in mentally disturbed children (author's transl)].

PMID- 1034676
TI  - [Schematical presentation of vibration of the vocal cord as a layer-structured
      vibrator.--Normal larynges-- (author's transl)].

PMID- 1034677
TI  - [Immediate effects of CO2 laser irradiation on soft tissue (author's transl)].

PMID- 1034678
TI  - [Clinical observation on the malignant tumors of the nasal cavity and paranasal
      sinuses: A 20-year survey (author's transl)].

PMID- 1034679
TI  - [Studies of auditory ability of hard-of-hearing patients. Part II: The
      relationship between self-rating and the results of audiometry (author's
      transl)].

PMID- 1034680
TI  - [A case of Wegener's granulomatosis with cancers of the thyroid gland and the
      cervix uteri (author's transl)].

PMID- 1034681
TI  - [Otoneurological findings of some medullo-cerebellar tumors (author's transl)].

PMID- 1034682
TI  - [Mechanism of deglutition--anatomy and physiology].

PMID- 1034683
TI  - [Studies on chemotherapeutics. IX. On the antimicrobial activity and syntheses of
      haloacetamidodiphenyl ether compounds and haloacetamidodiphenyl sulfide compounds
      (author's transl)].

PMID- 1034684
TI  - [Determination of phosphorus in cannabis by neutron activation analysis. 
      Measurement of 32P Cerenkov radiation by liquid scintillation spectrometer-
      (author's transl)].

PMID- 1034685
TI  - [Studies on drug metabolism by use of isotopes. XVIII. Ion cluster technique for
      detection of urinary metabolites of 1-butyryl-4-cinnamylpiperazine (author's
      transl)].

PMID- 1034686
TI  - [Physicochemical studies on the sedimentation state of suspension particles. VII.
      Studies of sedimentation state of pyrimidine penicillin G by electric
      conductivity method (author's transl)].

PMID- 1034687
TI  - [Effect of ephedrine-isopropylantipyrine on edema and increased vascular
      permeability (author's transl)].

PMID- 1034688
TI  - [Studies on the components of Atractylodes. II. New polyacetylenic compounds in
      the rhizome of Atractylodes lancea De Candolle var. chinensis Kitamura (author's
      transl)].

PMID- 1034689
TI  - [Studies on fluorometric analysis of phenol derivatives. VI. Fluorometric
      analysis of formaldehyde with phenylephrine hydrochloride and its application to
      determination of 1,2-propandiol compound (author's transl)].

PMID- 1034690
TI  - [Electronic properties of N-heteroaromatics. LVIII. Electronic interaction of
      some biologically active aminoacridines and deoxyribonucleic acid (DNA):
      ultraviolet hypochromism (author's transl)].

PMID- 1034691
TI  - [Decomposition and stabilization of drugs. XVII. Kinetic studies on the hydration
      of pentazocine in aqueous acidic media (author's transl)].

PMID- 1034692
TI  - [On the constituents of the essential oil from Lamium purpureum L. (author's
      transl)].

PMID- 1034693
TI  - [Studies on pyrazolo(3,4-d)pyrimidine derivatives. III. On the reaction of 1
      methyl- and 1-phenyl-4-chloro-1H-pyrazolo(3,4-d)-pyrimidine with carbanion
      (author's transl)].

PMID- 1034694
TI  - [Equilibria between copper (II) and acetate in N,N-dimethylformamide solutions
      (author's transl)].

PMID- 1034695
TI  - [The characteristics of uricase production by a Hyphomycetes isolated from the
      excrements of Cettia diphone cantans. V. Uricase production by pellicle in
      various growing stages (author's transl)].

PMID- 1034696
TI  - [A simple quantitative determination of ethanol in drugs by gas chromatography
      using the head-space analytical technique. I. Tincture (author's transl)].

PMID- 1034697
TI  - [Syntheses of (p-tolylsulfonyl)azines and azinecarbonitriles (author's transl)].

PMID- 1034698
TI  - [Alkaloids of Cephalotaxus wilsoniana Hay (author's transl)].

PMID- 1034699
TI  - Electrical excitability of cultured adrenal chromaffin cells.
AB  - 1. Adult human and gerbil adrenal medullary cells were maintained in dissociated
      cell culture and studied by micro-electrode penetration. 2. In the best
      recordings, chromaffin cell transmembrane potentials exceeded -50mV. 3.
      Chromaffin cells were capable of generating all-or-nothing over-shooting action
      potentials, similar to those generated by sympathetic neurones. 4. The action
      potentials were blocked by tetrodotoxin (TTX, 10(-6)g/ml.) but were not blocked
      by removal of Ca or by CoCl2 (10 mM). We conclude that the action potentials are
      probably generated by a Na mechanism. 5. Chromaffin cells are depolarized by the
      iontophoretic application of acetylcholine (ACh). This depolarization was
      accompanied by an increased membrane conductance and could trigger action
      potentials. 6. Action potentials were also found in cells in fresh slices of
      gerbil adrenal medullae.

PMID- 1034700
TI  - Competition between some neutral amino acids for carrier-mediated transport into
      the brain in vivo [proceedings].

PMID- 1034701
TI  - [Classification of oscillatory states of blood pressure after bleeding in cats
      (author's transl)].
AB  - Blood pressure and heart rate responses were recorded on bleeding of blood volume
      of 1 ml/kg body weight (test input) from the abdominal aorta of cat. Forward path
      gain, backward path gain and minification were determined from blood pressure
      responses to test input. Oscillations in blood pressure were elicited
      spontaneously or artificially after bleeding of blood volume of 5 ml/kg body
      weight (conditioning input). The oscillatory states are classified into latent
      state, underdamped oscillatory state and harmonic oscillatory state. Open loop
      gain decreased in the latent state but increased in the other states. Therefore,
      oscillation was hard to elicit in the latent state. Minification, however,
      enlarged in the latent state, making the system irritable to disturbances and
      reducing its control accuracy. In the latent state, an insensible disturbance
      increased backward path gain and open loop gain to induce the oscillations. There
      was an increase of heart rate at an elicitation of oscillation in any state and a
      decrease of heart rate made it damped. Therefore, the heart rate regulatory
      system plays a main role in the feedback path of the blood pressure regulatory
      system and an increase of heart rate by an insensible disturbance or test input
      increases backward path gain.

PMID- 1034702
TI  - Control of blood pressure oscillation elicited by bleeding.
AB  - 1) A control objective regarding the blood pressure oscillation is to decrease
      the heart rate. 2) The transfusion of a small amount of blood at the bottom of a
      cycle in the oscillation is usually useful as a control plan for the blood
      pressure oscillation. 3) A partial occlusion of the abdominal aorta is effective
      in arresting the oscillation, but the oscillation starts again after releasing
      the abdominal aorta from the partial occlusion.

PMID- 1034703
TI  - [Neuron activities of the motor cortex during conditioned eye blink reflex in
      rabbits (author's transl)].
AB  - Effects of the tone (CS) on neurons of the motor cortex were investigated in
      naive, pseudoconditioned, and conditioned rabbits. Conditioning to eye blink
      reflex was made by a combination of CS and air puff (US). Effects of electrical
      stimulation of the subcortical structures were also observed on the cortical
      neurons associated with the conditioned reflex. The results were as follows. (1)
      Proportion of neurons which significantly increased the firing rate in response
      to the CS, type E, was higher in the conditioned group than in other two groups.
      On the other hand, no group difference was found in the proportion of neurons
      which significantly decreased the firing rate to the stimulus, type I. (2) Most
      of the type E neurons in the conditioned rabbits began to fire at latencies of
      about 50 to 100 msec after the CS, preceding about 200 msec to the appearance of
      the peripheral conditioned responses (EMG). (3) Most of the type E neurons in the
      conditioned animals were more easily affected by stimulation of the medial
      geniculate body and the brain stem reticular formation. Based on the results
      mentioned above, it is concluded that in the rabbits conditioned to the eye blink
      reflex, excitability of neurons in the motor cortex is enhanced by the tone (CS),
      and by electrical stimulation to the medial geniculate body and the brain stem
      reticular formation.

PMID- 1034704
TI  - Separation technique of phase-locked and -unlocked spikes to the vibratory
      stimulation in the tonic vibration reflex.

PMID- 1034705
TI  - [Changes of electromyographic discharges by stretch reflex in the course of
      muscle fatigue (author's transl)].

PMID- 1034706
TI  - [Mondor's disease. A radioclinical diagnosis, concerning one case (author's
      transl)].
AB  - The authors present a typical case of Mondor's disease of the superior external
      quadrant of the breast. They discuss two specific points: --the absence of
      superior-internal venous drainage; --the radiological picture given by a
      thrombosed vein.

PMID- 1034707
TI  - Preparation of cultured cells for SEM: air drying from organic solvents.
AB  - Air evaporation from organic solvents of differing polarities and surface free
      energies was used in the preparation of cultured murine peritoneal macrophages
      for scanning electron microscopy (SEM). The surface structural features of these
      cells were compared to the surfaces of similar cells prepared by the critical
      point procedure. In general, all organic solvents produced a marked collapse of
      cell structure resulting in an increase in surface irregularity. Fracture
      surfaces and sharply defined contours including numerous flaps and ridges were
      characteristic of the non-polar solvent dehydrated samples. Polar solvent
      dehydrated samples, including those dried from solvents of low surface free
      energy, exhibited a secondary flowing and settling of the cell membrane. Primary
      collapse was apparent but cell contours were smoothed and rounded. Overall cell
      shape and cell-to-cell relationships were retained regardless of solvent type. It
      is suggested that solvent evaporation may prove useful in certain cases, though
      investigators are advised to use caution when interpreting the results obtained
      by such procedures.

PMID- 1034708
TI  - Heterogeneity of spacer lengths in circles of amplified ribosomal DNA of two
      insect species, Dytiscus marginalis and Acheta domesticus.

PMID- 1034709
TI  - Issues in the use of psychophysiology to assess female sexual dysfunction.
AB  - The viability of psychophysiology as an assessment approach for female sexual
      function and dysfunction revolves around physiological measurement issues,
      subjective measurement issues, and the nature of the sexual difficulty. Recent
      data are presented and discussed as are the potentials and limitations inherent
      in a psychophysiological study of human sexuality. A case is made for the use of
      vaginal pressure pulse as a primary measure, vaginal blood volume as a secondary
      measure, correlations between subjective and objective measures of sexual
      arousal, and intercorrelations between various subjective affect scales.

PMID- 1034710
TI  - Androgens and male sexual function: a review of human studies.
AB  - The scope of this article will be a review and brief discussion of recently
      gathered information on androgens and sexual behavior in men. It will include
      experimental observations on the covariance between androgens, mainly
      testosterone, and sexual functioning in normal heterosexual men and studies on
      sexual dysfunction and homo-sexual behavior. The effects of castration,
      hypogonadal conditions, hormonal replacement, and endogenous testosterone
      variations on sexual behavior are examined. Further psychoendocrine studies, are
      necessary to evaluate the role of gonadal hormone production in impotency.
      Current pharmacological research does not furnish specific evidence, that the
      administration of androgens or preparations that stimulate the secretion of
      endogenous androgens have beneficial effects on functional impotence. After
      reviewing the studies on male homosexuality and androgen levels, the article
      concludes that it has not been established that homosexual men are characterized
      by abnormalities in plasma testosterone.

PMID- 1034711
TI  - Isolation of Monosporium apiospermum from cerebrospinal fluid.

PMID- 1034712
TI  - A beta-adrenergic stimulant, salbutamol, in the treatment of pertussis.

PMID- 1034713
TI  - [Sub-urethral pouches in the adult female (author's transl)].
AB  - With reference to 15 cases, the authors carried out a diagnostic and therapeutic
      study of "suburethral pouches" in the adult female. They emphasize the importance
      of the micturition phase of intravenous pyelography and retrograde cystography.
      Retrograde urethrography is rarely necessary. Surgical indications must be
      limited by the undisputable risks of this form of surgery.

PMID- 1034714
TI  - [Recent trends in pediatric anesthesia. Clinical experience at the National
      Children's Hospital in the last 10 years].

PMID- 1034715
TI  - [Physiological and pharmacological consideration on cardiac resuscitation (1)].

PMID- 1034716
TI  - [Influence of altered reticuloendothelial phagocytic function on organ and
      intracellular distribution of 51Cr-labelled endotoxin in mice].

PMID- 1034717
TI  - [Experimental study of acute cardiac arrest caused by nitrous oxide inhalation
      and neurological resuscitation--with special reference to polarography and oxygen
      availability].

PMID- 1034718
TI  - [Effects of thiamylal on the vascular smooth muscle].

PMID- 1034719
TI  - [Experimental study on hemorrhagic shock--with special reference to infusion
      fluid, blood perfusion, dexamethasone, phenoxybenzamine and left cardiac
      hemodynamics].

PMID- 1034720
TI  - [Local anesthetic action of CH3-B12. (1) Stellate ganglion block].

PMID- 1034721
TI  - [Treatment of severe metabolic alkalosis].

PMID- 1034722
TI  - [Intracranial epidural hematoma following open heart surgery].

PMID- 1034723
TI  - [Disappearing laryngeal polyp].

PMID- 1034724
TI  - [Problems of long-term airway management in infants and children - with special
      reference to nasotracheal intubation and tracheostomy].

PMID- 1034725
TI  - [Anesthetic management of patients with cardiac pacemaker].

PMID- 1034726
TI  - [Device for voice production by patient during artificial ventilation after
      tracheotomy].

PMID- 1034727
TI  - [Remodeling of the MacIntosh laryngoscope for edentulous patient].

PMID- 1034728
TI  - [Physiology and pharmacology related to cardiac resuscitation (2)].

PMID- 1034729
TI  - [Anesthesia suitable for laryngomicrosurgery and functional examination of th
      larynx during operation --modified NLA and doxapram].

PMID- 1034730
TI  - [Effects of halothane on the ATP levels of the liver, muscles, and blood in
      dogs].

PMID- 1034731
TI  - [Changes in serum dopamine beta-hydroxylase activities and hypertension during
      excision of adrenal tumor].

PMID- 1034732
TI  - [New technic for blocking the 2nd division of the trigeminal nerve. Experimental
      and clinical studies on "suprazygomatic route"].

PMID- 1034733
TI  - [CT 1341 (Althesin-Glaxo) for anesthetic for dilatation and curettage].

PMID- 1034734
TI  - [Temperature correction tables for blood Po2].

PMID- 1034735
TI  - [Anesthetic problems in progressive systemic sclerosis].

PMID- 1034736
TI  - [Anesthesia for cleft palate associated with congenital tracheal stenosis].

PMID- 1034737
TI  - [Anesthesia in complete right bundle branch block, with special reference to its
      progression to complete A-V block].

PMID- 1034738
TI  - [Open heart surgery with deep hypothermia and modified neuroleptansesthesia
      (droperiodol-pentazocine) in infants].

PMID- 1034739
TI  - [Enflurance anesthesia in primary aldosteronism, with special reference to its
      effects on serum aldosterone levels].

PMID- 1034741
TI  - [Training of nurse anesthetists in Indonesia].

PMID- 1034740
TI  - [Effects of modified neuroleptanesthesia on dopamine beta-hydroxylase].

PMID- 1034742
TI  - [Induction and repression of L-arabinose isomerase in Vibrio parahaemolyticus].

PMID- 1034743
TI  - [Defective utilization of various carbon sources in a mutant of Vibrio
      parahaemolyticus lacking a component of the phosphoenolpyruvate: sugar
      phosphotransferace system].

PMID- 1034744
TI  - [Disseminated intravascular coagulation (DIC)].

PMID- 1034745
TI  - [Studies on somotic fragility and morphological changes of antibody-senstiized
      erythrocytes. I. Its decreased osmotic fragility, observed by coil planet
      centrifuge (author's transl)].

PMID- 1034746
TI  - [Studies on osmotic fragility and morphological changes of antibody-sensitized
      erythrocytes. II. Its ultra-structural and morphological changes (author's
      transl)].

PMID- 1034747
TI  - [Studies on aminopeptidase activity in human blood cells (author's transl)].

PMID- 1034748
TI  - [A case of "minor anomaly type" myeloma with atypical cell morphology (author's
      transl)].

PMID- 1034749
TI  - [Plasma-cell like sarcoma presenting as transverse myelopathy. Report of an
      autopsied case (author's transl)].

PMID- 1034750
TI  - [A case of disseminated eosinophilic collagen disease (author's transl)].

PMID- 1034751
TI  - [Development of malignant tumor after anti-tumor therapy or immunosuppresive
      therapy].

PMID- 1034753
TI  - [Re-evaluation of intermittent therapy and Uzuka's 2-step therapy in acute
      leukemia].

PMID- 1034752
TI  - [A case of leuekmic reticuloendotheliosis of chronic form in a child (author's
      transl)].

PMID- 1034754
TI  - [A new method for measuring platelet fibrinogen levels by the use of the FDP-kit
      (author's transl)].

PMID- 1034755
TI  - [Evaluation of the new bone marrow biopsy device, Jamshidi needle. Clinical
      importance of the bone marrow biopsy (author's transl)].

PMID- 1034756
TI  - [Diagnostic and prognostic value of bone marrow culture in preleukemia (author's
      transl)].

PMID- 1034757
TI  - [Increase of alcohol consumption and alcoholic hepatic diseases--trends in Japan
      and comparison with the Western nations].

PMID- 1034758
TI  - [Alcohol consumption and liver diseases].

PMID- 1034759
TI  - [Clinicopathological classification of alcoholic liver diseases].

PMID- 1034760
TI  - [Acute alcoholic hepatitis].

PMID- 1034761
TI  - [Characteristics of alcoholic liver diseases in Japan, with special reference to
      the modification brought about by viral hepatitis].

PMID- 1034762
TI  - [Characteristics of fatty liver according to its etiology and differential
      diagnosis, with special reference to alcoholic fatty liver].

PMID- 1034763
TI  - [Liver function patterns in alcoholic liver diseases].

PMID- 1034764
TI  - [Serum lipids characteristic to alcoholic liver diseases].

PMID- 1034765
TI  - [Alcoholic liver diseases associated with psychoneurological symptoms].

PMID- 1034766
TI  - [Mechanism of development from alcoholic liver diseases to liver cirrhosis].

PMID- 1034767
TI  - [Alcoholic liver cirrhosis and viral liver cirrhosis].

PMID- 1034768
TI  - [Management of alcoholic liver diseases].

PMID- 1034769
TI  - [Congenital heart defects].

PMID- 1034770
TI  - [Dextrocardia--mirror image dextrocardia and dextroversion].

PMID- 1034771
TI  - [Colonic diverticulosis].

PMID- 1034772
TI  - [Surgical management of choroid plexus papilloma].

PMID- 1034773
TI  - [Degrees and titles in England--on Dr. Watson].

PMID- 1034774
TI  - [Present status and prospect of artificial beta cells of pancreas].

PMID- 1034775
TI  - [Dendrogram of chemical constituents in serum. Hieraychical classifications by
      fuzzy relations (author's transl)].

PMID- 1034776
TI  - [Diagnosis of bladder neoplasms, with special reference to the degree of
      invasiveness].

PMID- 1034777
TI  - [Cytodiagnosis of urine in bladder neoplasms].

PMID- 1034778
TI  - [Radiographic diagnosis of bladder neoplasms].

PMID- 1034779
TI  - [Structure and function of proteoglycan and glycoprotein (author's transl)].

PMID- 1034780
TI  - [Arylsulfatase and chronic hepatic damage (author's transl)].

PMID- 1034781
TI  - [On histopathological examination for parasitic diseases (author's transl)].

PMID- 1034782
TI  - [Population study of serum protein fraction. Part I.-Sex and age distribution of
      each component (author's transl)].

PMID- 1034783
TI  - [Preparation and application of specific anti-pregnance zone protein serum
      (author's transl)].

PMID- 1034784
TI  - [A new enzymatic determination of cholesterol and comparison of various
      cholesterol oxidases (author's transl)].

PMID- 1034785
TI  - [Application of superoxide dismutase to clinical chemistry. 1. Simple
      colorimetric determination method of human serum superoxide dismutase (author's
      transl)].

PMID- 1034786
TI  - [Exclusive determination of placental and non-placental LAP in pregnancy serum
      (author's transl)].

PMID- 1034787
TI  - [A technical device for recording of His-bundle potential from body surface
      (author's transl)].

PMID- 1034788
TI  - [Pulmonary function in healthy subjects and its prediction. 5. Pulmonary
      diffusing capacity in adults (author's transl)].

PMID- 1034789
TI  - [Classification of ringworm infections (author's transl)].

PMID- 1034790
TI  - [Pathology of cutaneous reticulosis (author's transl)].

PMID- 1034791
TI  - [Some clinical aspects of herpes simplex, especially about recurrences (author's
      transl)].

PMID- 1034792
TI  - [Clinical study and treatment of herpes zoster (author's transl)].

PMID- 1034793
TI  - [Virus warts, clinical manifestations and treatment (author's transl)].

PMID- 1034794
TI  - [Clinical features and therapy of pustulosis palmaris et plantaris (author's
      transl)].

PMID- 1034795
TI  - [Evaluation of tonsillectomy for pustulosis palmaris et plantaris (author's
      transl)].

PMID- 1034796
TI  - [Studies of fibrinolytic activity in the lesion of pustulosis palmaris et
      plantaris (author's transl)].

PMID- 1034797
TI  - [Healing of pustulosis palmaris et plantaris (author's transl)].

PMID- 1034798
TI  - [Survey of current therapy of pustulosis palmaris et plantaris in Japan: is
      systemic administration of adrenocorticosteroids beneficial (author's transl)?].

PMID- 1034799
TI  - Pustulosis palmaris et plantalis investigated from the viewpoint of metal allergy
      (II) (author's transl).

PMID- 1034800
TI  - Pachyonychia congenita with Steatocystoma multiplex: a report of 12 cases in one
      family [author's transl].

PMID- 1034801
TI  - [Prognosis after resection of gastric neoplasms. 1. Clinicopathological factors
      and follow-up studies].

PMID- 1034802
TI  - [Gastric acid response of Heidenhain pouch and serum gastrin level after various
      types of vagotomy].

PMID- 1034803
TI  - [Significance of hepatitis B virus (HBV) infection in chronic hepatitis with
      special reference to cellular immunity].

PMID- 1034804
TI  - [Studies of bile acid deconjugation in intestinal obstruction].

PMID- 1034805
TI  - [Endotoxin in liver cirrhosis. 1. Endotoxin in contained the ascitic fluid in
      liver cirrhosis].

PMID- 1034806
TI  - [Peroral cholangiopancreatoscopy (PCPS): its development and clinical
      application].

PMID- 1034807
TI  - [Diagnosis of extrahepatic obstructive jaundice with ultrasonic tomography, with
      special reference to differentiation from intrahepatic cholestasis].

PMID- 1034808
TI  - [Two cases of Gilbert's syndrome, with special reference to results of reduced
      caloric intake and nicotinic acid test (author's transl)].

PMID- 1034810
TI  - [Present state and current trends in laboratory tests].

PMID- 1034809
TI  - [Diagnostic standard for Crohn's disease (proposal)].

PMID- 1034811
TI  - [Biofeedback].

PMID- 1034812
TI  - [Mathematical analysis of the geometrical optical illusion in the perceptual
      field].

PMID- 1034813
TI  - [Optimal mechanical properties of branching structures in trees].

PMID- 1034814
TI  - [Implantable socket for long-term intermittent percutaneous electric pathways].

PMID- 1034815
TI  - [Feedback control of the alpha waves].

PMID- 1034816
TI  - [Impedance cardio-telemeter].

PMID- 1034817
TI  - [Properties of biomaterials. (6) Application to biological systems].

PMID- 1034818
TI  - [Experimental studies on impedance plethysmography].

PMID- 1034819
TI  - [Estimated activity of the optic nerve based on the pupil].

PMID- 1034820
TI  - [Catheter-tip pressure transducer with photofiber].

PMID- 1034821
TI  - [Determination of cardiac dynamics by microwaves].

PMID- 1034822
TI  - [Impedence cardio-pulmography].

PMID- 1034823
TI  - [Screening device for cardiac diseases among school children].

PMID- 1034824
TI  - [Reaction of kidney tissue to concanavalin A. 1. Studies with FITC-labelled
      concanavalin A].

PMID- 1034825
TI  - [Electron microscopic study of the kidney in systemic Shwartzman reaction].

PMID- 1034826
TI  - [Structure of the kidney medulla of mature rabbits. Morphological relationship
      between the tubules and blood vessles].

PMID- 1034827
TI  - [Renal involvement in Schonlein-Henoch purpura in adult].

PMID- 1034828
TI  - [Accumulation of physiologically active macromolecules in patients under
      hemodialysis, with special reference to the significance of high ribonulcease
      activities].

PMID- 1034829
TI  - [Serum transferrin levels in chronic renal failure. 1. Serum transferrin levels
      in patients under hemodialysis, with special reference to its relationship with
      food intake].

PMID- 1034830
TI  - [Morphological study on the collecting duct and interstitium of the kidney of
      normal rabbits].

PMID- 1034831
TI  - [Studies of molecular pharmacology of thiazide diuretics].

PMID- 1034832
TI  - [The 3- and 4-point experiments and a test of homogeneity in binocular visual
      space (author's transl)].
AB  - The variability of the 2 parameters in the Luneburg model, sigma (the degree of
      depth perception) and K (the curvature of binocular visual space), was examined.
      The 3- and 4-point experiments were performed to estimate these parameters by
      using various sized stimulus configurations. For 2 of the Os used, it was found
      that the value of K was inversely related to the size of stimulus configuration
      (SSC) while the value of sigma was constant. This finding was discussed referring
      to previous investigations and problems: The discrepancy in the estimated values
      of K between the alley experiment and 3- and 4-point experiments, equidistance
      tendency, and angular separation problem in the traditional size constancy
      experiment.

PMID- 1034833
TI  - [Effect of tone on perception of figures in children (author's transl)].
AB  - This experiment was designed to examine the effect of tone on the perception of
      figures in children, presenting a tone together with figures. On the basis of
      studies concerning sensory interaction, the factors producing perceptual changes
      of figures were also examined. It was found that the change of figure perception
      was caused by tones, not by suggestions nor by differences in pitch. Significant
      difference was obtained between the conditions with and without tones. The
      changes in color, shape, size, position and color shade were observed. As the
      extreme case of the inhibitional effect of color shades, the disappearance of
      figure perception was also observed. The results obtained in this experiment were
      discussed in relation to the sensory developmental study.

PMID- 1034834
TI  - Experimental gastric ulcers in the fundic gland area following transplantation of
      the gastric-wall pedicles.
AB  - Using adult mongrel dogs, a portion of the anterior gastric wall of the pyloric
      gland area was transplanted into the fundic gland area using the Z-plastic
      procedure forming an islet. Three weeks postoperatively, 2 per cent histamine in
      sesame oil was injected intramuscularly in a daily dose of 2 mg/kg body weight.
      Ulcers developed in the graft in nine of 19 animals. The factors responsible to
      the development of the ulcers may well be circulatory disturbance and reduction
      of mucosal resistance following surgical insult, and continuous irritation caused
      by gastric juice. When a portion of the anterior gastric wall of the fundic gland
      area was transplanted into the fundic gland area followed by administration of
      histamine in sesame oil, ulcers developed in the graft only in four of 12
      animals. Histological examination revealed the regenerated epithelium at the
      margin of the ulcers. Thus the ulcers presently induced may provide an useful
      experimental model for ulcers in the fundic gland area.

PMID- 1034835
TI  - [Pulmonary fibrosis. 1) Epidemiological survey].

PMID- 1034836
TI  - [Radiological findings of pulmonary fibrosis].

PMID- 1034837
TI  - [Pathomorphological findings of chronic diffuse interstitial pneumonia of unknown
      etiology].

PMID- 1034838
TI  - [Clinical pictures of diffuse interstitial pneumonia].

PMID- 1034839
TI  - [Respiratory function in pulmonary fibrosis].

PMID- 1034840
TI  - [Diffuse interstitial pulmonary fibrosis--fibrosing mechanism of the lung].

PMID- 1034841
TI  - [A case of myxedema coma with marked respiratory failure (author's transl)].

PMID- 1034842
TI  - Studies on Yersinia pseudotuberculosis. IV. Isolation of Y. pseudotuberculosis
      from healthy swine.

PMID- 1034843
TI  - Clinical and pathological studies on a spontaneous case of canine systemic
      atrophic myositis.

PMID- 1034844
TI  - Delayed hypersensitivity responses of guinea pig and rat to Angiostrongylus
      cantonensis infection.

PMID- 1034845
TI  - The gastric venous system of the domestic goose.

PMID- 1034846
TI  - Cadmium-binding protein in tissues of male rats and Japanese quail.

PMID- 1034847
TI  - Bacteriophage typing of Staphylococcus aureus isolated from chicken
      staphylococcosis in Japan.

PMID- 1034848
TI  - A device for detection of heat in heat-silent buffaloes.

PMID- 1034849
TI  - [Histochemical changes in the endometrium of the goats during the course  of
      estrous cycle and pregnancy (author's transl)].

PMID- 1034850
TI  - Genetic marker in beagle blood: individual difference within blood groups
      detected by isohemagglutinin.

PMID- 1034851
TI  - [Changes of arterial pressure and biosynthesis of corticosteroids in rats with
      neurogenic stress].
AB  - By way of a "psychogenic stimulation" (crowding for 1, 7 and 15 days) neurogenic
      hypertension was induced in male rats that developed in them within 11--15 days
      of the tsne of the stress. The biosynthesis of aldosterone, corticosterone, 11
      dehydrocorticostrone and desoxycorticosterone by the adrenal glands of the rats
      in vitro from progesterone-14C appeared to greatly increased on the 1st day of
      stress. In 7 days of the beginning of stress the production of labelled
      corticosteroids fell to controlvalues (with the exception of 11
      dehydrocorticosterone which production was growing still further). By the 15th
      day of stress reduction of the biosynthesis of aldosterone, corticosterone and
      desoxycorticosterone was observed, as well as normalization of the biosynthesis
      of 11-dehydrocorticosterone.

PMID- 1034852
TI  - [Plastic closure of a defect in the chest wall following extensive radical
      mastectomy].

PMID- 1034853
TI  - Malignant haemangioendothelioma (angiosarcoma) in the dog.

PMID- 1034854
TI  - Spontaneous neoplasms of the central nervous system of the cat.

PMID- 1034855
TI  - Estradiol receptors: influence of plasma proteins on detection and quantitation.

PMID- 1034856
TI  - A radioimmunoassay for betamethazone. Preparation of a specific antiserum to
      betamethazone-3 (O-carboxymethyl) oxime-bovine serum albumin and evaluation of
      method.

PMID- 1034857
TI  - Application of theoretical models in ecology.

PMID- 1034858
TI  - Studies of pharmacological activity several acridine derivatives with cytostatic
      and oncostatic properties.

PMID- 1034859
TI  - Behavior of some biochemical components of blood of patients with ovarian
      carcinoma during Ledakrin treatment.

PMID- 1034860
TI  - Antineoplastic activity of C-283 preparation (Ledakrin) in model experiments.

PMID- 1034861
TI  - Experimental investigations on the different hepatotoxic potential of
      erythromycin derivatives.

PMID- 1034862
TI  - [Endocrine secretions and states of vigilance].

PMID- 1034863
TI  - [Pelvis teaching model for gynecologic examination].

PMID- 1034864
TI  - Trypsin and chymotrypsin inhibitors from soybeans.

PMID- 1034865
TI  - Effect of certain nitrogenous heterocyclic compounds on carotenogenesis in
      Verticillium agaricinum.
AB  - Pyridine, isonicotinoylhydrazide and 1-methylamidazole have been used to
      investigate carotenoid biosynthesis in V. agaricinum. The results suggest that
      both torulin (C40) and neurosporaxanthin (C35) are formed from the precursors
      phytoene and phytofluene. These was no evidence of lycopene accumulation under
      these conditions. After 4 days' growth in the presence of isocotinolyhydrazine
      the fungus contained torulin and neurosporaxanthin only, whereas after 7 days,
      seven other carotenoids appeared as well, some of which were at the early stages
      of carotenoid biosynthesis. There results cannot be explained on the basis of a
      system consisting of free enzymes but of an enzyme aggregate already proposed for
      Phycomyces.

PMID- 1034866
TI  - [Morphogenetic action of trichothecin on Trichothecium roseum].
AB  - Trichothecin and some conditions of cultivation, especially high concentrations
      of carbon favour differentiation of the submerged mycelium of Trichothecium
      roseum, i.e. formation of submerged conidia, bud forming cells, chlamidospores,
      chains of barrel-shaped cells capable of germination and development of new
      generations of the submerged mycelium. Biosynthesis of trichothecin is connected
      with growth of these generations of the mycelium which are characterized by a
      high dehydrogenase activity. Synthesis of fibrinolytic enzymes is also possible
      in the period of growth of a weakly differentiated mycelium.

PMID- 1034867
TI  - [Possible participation of mitochondria in formation of peroxisomes in yeasts].
AB  - The origin of peroxisomes in yeast organisms is still unknown. These organelles
      are believed to be formed, similar to animal cells, from the endoplasmatic
      reticulum. However, this has not been confirmed directly. Peroxisomes are often
      found to be in contact with channels of the endoplasmatic reticulum and, in our
      experiments, with mitochondria of yeast organisms, especially those which utilize
      oleic acid, n-alkanes and methanol as a sole source of carbon. In Rhodotorula,
      peroxisomes are characterized by the same "bean" configuration and paired
      arrangement imitating "copulation" as mitocondria. In Kloeckera boidinii, a
      mitochondrion was transformed into a peroxisome and cristae were lost. A part of
      the peroxisome still possessed a double membrane typical of mitochondria while
      another part had a single membrane characteristic of peroxisomes. Further studies
      are being carried out in order to find if this is a general relationship or one
      of possibilities.

PMID- 1034868
TI  - [Improvement of x-ray spectrometric results by a modified background-ratio
      method].

PMID- 1034869
TI  - Mycobacterium marinum infection from a tropical fish tank. Treatment with
      trimethoprim and sulphamethoxazole.
AB  - A paronychial granuloma on the left thumb, in a man who kept tanks of tropical
      fish, was followed by cutaneous nodules on the left upper limb and tender lymph
      nodes in the left axilla. Mycobacterium marinum was isolated from the lesion on
      the thumb and also from the tank water. Subsidence of the lesions followed
      administration of trimethoprim and sulphamethoxazole.

PMID- 1034870
TI  - [Histo-morphological characteristics of the kidney glomerulus in liver
      cirrhosis].

PMID- 1034871
TI  - [Therapy with cytostatic immunosuppressive agents in various children's
      diseases].

PMID- 1034872
TI  - [Children's play in the hospital].

PMID- 1034873
TI  - [Nontumoral infantile hydrocephalus. Long-term catamnestic study of 346 cases
      with cerebrospinal fluid shunt].

PMID- 1034874
TI  - Isolation and characterization of compatible diploids of Schizophyllum commune.
AB  - Common-AB diploids with several heterozygous biochemical markers were mated with
      appropriately marked haploid strains of S. commune in an effort to obtain
      compatible, common-A, and common-B diploid progeny with biochemical markers
      identical to those of the common-AB parent. The spores from these crosses were
      germinated on minimal medium. Five compatible diploids, but no common-A or common
      B diploids, marked as desired, were isolated by this method. Two possessed some
      dikaryotic cells and two had many dikaryotic cells. One of the latter was shown
      to have peculiar behaviour associated with one of its B mating-type factors.

PMID- 1034875
TI  - [Studies into carbohydrate metabolism of sows in advanced pregnancy, with
      particular reference to piglet birth weight (author's transl)].

PMID- 1034876
TI  - [Studies into carbohydrate metabolism in newborn piglets (author's transl)].

PMID- 1034877
TI  - The dominant lethal effect of dietary triethylenemelamine.
AB  - Triethylenemelamine (TEM) was administered in the diet to adult male mice at
      doses of 0.1, 0.3, 1, 10 or 50 mg/kg body weight for 45 days or at doses of 0.1
      or 0.3 mg/kg b.w. for 10 days. As a comparison, male mice were treated
      intraperitoneally with 5 daily doses of 0.25 or 0.5 mg TEM/kg b.w. At the end of
      the treatment period, males were mated sequentially with 2 untreated virgin
      females each for 2 or 3 weeks. Near mid-pregnancy the number of implantation
      sites and fetal deaths were determined. TEM, administered in the diet at 10 or 50
      mg/kg b.w. for 45 dyas, was lethal to male mice. Surviving males from the 1 mg/kg
      level failed to impregnate any females during the two matings. TEM, given in the
      diet at 0.1 or 0.3 mg/kg for 10 or 45 dyas, decreased fertility and increased
      dominant lethal mutations in a dose and time dependent manner. These results were
      comparable to those obtained from males treated i.p. with TEM at 0.25 or 0.5
      mg/kg b.w.

PMID- 1034878
TI  - Description and chemical analysis of a new species of hallucinogenic Psilocybe
      from the Pacific Northwest.

PMID- 1034879
TI  - Psychotropic mycoflora of Washington, Idaho, Oregon, California and British
      Columbia.

PMID- 1034880
TI  - Re-analysis of radiation-induced specific locus mutations in the mouse.
AB  - A re-analysis of published data on mouse mutation rates induced by X and gamma
      rays suggests that the kinetics of induction can be analysed by fitting the data
      to a parabolic curve. We interpret this to mean that a substantial proportion of
      the induced mutations results from gross chromosomal changes such as deletions,
      some of which are one-track and some of which are two-track. This analysis is
      based on the assumption that the shape of the dose curve, which in the female is
      concave upward, reflects the manner in which the mutations are induced rather
      than representing a one-track (linear) curve whose shape has been modified by
      differential repair.

PMID- 1034881
TI  - Production of immunoglobulins by tumor cell lines from avian lymphoid leukosis.
AB  - Two avian lymphoma cell lines, 1104-X-5 and 1104-B, were examined for ability to
      produce immunoglobulin. They were found to produce and release the components of
      immunoglobulins related to IgG and IgM. The analysis of sucrose density gradient
      and gel electrophoresis suggested that these components might consist of light
      chains and fragments of heavy chains.

PMID- 1034882
TI  - Activity of the nigro-striatal dopaminergic system during precipitated morphine
      withdrawal investigated in rats with acute unilateral inactivation of the
      striatum.
AB  - The activity of the striatal dopamine system during precipitated morphine
      withdrawl was studied in rats using a model in which the striatum was
      unilaterally inactivated by the local injection of KCl. In naive rats dopamine
      agonists administered just prior to KCL induced ipsilateral turning or circling,
      while dopamine antagonists in the same situation caused contralateral turning.
      Withdrawal precipitated by morphine antagonists in rats made dependent by
      repeated implantation of morphine pellets induced contralateral circling during
      unilateral inactivation of the striatum. This contralateral circling was only
      slightly enhanced by haloperidol, but strongly enhanced by a low dosage of
      apomorphine as well as by some weak dopamine agonists such as CB 154 or By 101.
      However, high doses of apomorphine completely reversed the withdrawal-induced
      contralateral circling into ipsilateral circling. Other dopamine agonists, such
      as d-amphetamine, L-Dopa and piribedil, did not abolish the withdrawal-induced
      contralateral circling, however, they caused the appearance of an additional
      ipsilateral circling. Other types of drugs which are known to intensify
      withdrawal-induced jumping (desipramine, atropine, caffeine) enhanced
      contralateral circling. There are also other parallels jumping and contralateral
      circling induced by withdrawal. The direction of naloxone-induced asymmetric
      behaviour during acute unilateral inactivation of the striatum suggests that
      striatal dopaminergic activity is reduced during precipitated withdrawal; the
      other results reported point to the possiblity that extrastriatal dopaminergic
      mechanisms or different dopamine receptor types within the striatum are involved.

PMID- 1034883
TI  - [Verruca seborrhoica (senilis), adnexa and related problems].

PMID- 1034884
TI  - [Trigeminal neuralgia -- surgical technique (author's transl)].

PMID- 1034885
TI  - [Automatism (author's transl)].

PMID- 1034886
TI  - [Maxillary artery to middle cerebral artery anastomosis in dog-- a new
      experimental model (author's transl)].
AB  - End-to-side anastomosis between the maxillary artery and a branch of the middle
      cerebral artery was performed in the dog. The technique was devised as a new
      experimental model for extracranial-intracranial arterial shunt operation. The
      middle cerebral artery was ligated at the origin through a subtemporal small burr
      hole under the operating microscope in 13 dogs. Then, the shunt operation was
      carried out in 8 dogs 4 hours after the ligation(acute state), and in 5 dogs 3
      weeks after(chronic stage). The patency of the anastomotic site was evaluated by
      the selective external carotid angiography 2 weeks after the shunt operation. In
      the acute stage of 8 dogs, 7 cases showed patency of anastomosis (88%), and in
      the chronic stage of 5 dogs, arteriogram revealed 4 patent anastomosis (80%). In
      successful cases, arteriogram showed excellent filling of the entire territory of
      the middle cerebral artery through the shunts (Fig. 4, 5). Various types of
      experimental shunt operation were attempted in our review of the literature.
      Among them, the anastomosis between the superficial temporal artery and a branch
      of the middle cerebral artery by Yasargil (1967) is rather popular and this
      procedure has been used by some investigators including us to investigate the
      effect of the extracranial-intracranial shunt on experimental acute stroke. So
      far as dog's experiment is concerned, the superficial temporal artery appeared to
      be not suitable for a donor artery, because the superficial temporal artery runs
      far from the middle cerebral artery and its distal part is extremely small in
      caliber. Therefore, the superficial temporal artery was often obstructed by
      compression, kinking or narrowing by surrounding tissues and by adhesion to the
      bone edge of the burr hole. On the other hand, the maxillary artery of the dog,
      which is the largest terminal branch of the external carotid artery, has plenty
      of blood flow and suitable size for end-to-side anastomosis to the middle
      cerebral artery. In addition, maxillary artery is located very close to the
      proximal part of the middle cerebral artery. These anatomical and spatial
      advantage of the maxillary artery seemed to be favorable donor artery to the
      middle cerebral artery and have brought hight patency rate in our series of
      anastomosis than that of the other previous experimental extracranial
      intracranial shunts. To our knowledge, this is the first report on successful
      patent shunt formation after long-term occlusion of the middle cerebral artery in
      animals. Now, it is in our mind that progress of the study can be expected  in
      the field of extracranial-intracranial shunt operation for cerebral infarction by
      this experimental procedure.

PMID- 1034887
TI  - [Endocrinological evaluation of sellar and suprasellar tumor cases (the seventh
      report)--endcrinological study on four cases of pituitary adenoma with
      intratumoral hemorrhage (author's transl)].
AB  - Four cases of pituitary adenoma with intratumoral hemorrhage were studied
      endocrinologically. 1) It would be suggested that ACTH and TSH secretion of these
      cases was strongly impaired but LH, FSH and PRL secretion was fairly preserved
      immediately after hemorrhagic episode. 2) Two of these four cases revealed normal
      TSH secretion and normal thyroid function following the period of excessive TSH
      secretion and impaired thyroid function.

PMID- 1034888
TI  - [Cerebrospinal fluid flow dynamics in cerebral infarction--Numerical study with
      RI Anger camera (author's transl)].
AB  - Although the cerebral blood flow dynamics in cerebral infarction has already been
      studied by many investigators, the CSF flow dynamics in cerebral infarction has
      not been well discussed. The purpose of this paper is to investigate CSF flow
      dynamics in chronic cerebral infarction by RI cisternography and our new
      quantitative method. In 12 patients with cerebral infarction, the flow of CSF was
      estimated following intrathecal injection of 169Yb-DTPA or 111In-DTPA. In this
      study, in addition to the conventional cisternograms, quantitative evaluation of
      CSF flow was performed in 6 patients by our method. Our previous work included
      the quantitative CSF flow dynamics in 26 various cerebral disorders using RI
      Anger camera. This method consisted of following procedure: 30 minutes after RI
      injection, RI activity was studied continuously for 30 minutes, afterwards
      playing back the record to calculate the changes of RI activity in the optimal
      regions of interest. These operations were performed with Anger camera, accessory
      digital ratemeter and tape-recorder. The changes of RI activity which appeared to
      be linear is called flow rate in our study for convenience. In this report, the
      region of interest was selected at Sylvian cistern. 6 patients had abnormal
      cisternograms consisting of reflux of tracer into the ventricle and delayed
      migration of tracer to the basal cisterns and diminished flow of tracer in the
      affected hemisphers. In 5 patients whose cisternograms could not demonstrate the
      laterality of RI perfsion over the cerebral hemishere, a marked difference of
      flow rate between right and left Sylvian cisterns was found. These findings
      probably indicated the correlation between cerebral blood flow dynamics and CSF
      flow dynamics in cerebral infarction. Moreover, it was confirmed that our method
      could be of clinical use to evaluate CSF flow dynamics quantitatively. The
      possible mechanisms of CSF flow disturbance in the affected hemisphere following
      cerebral infarction was discussed.

PMID- 1034889
TI  - [Intracranial collision tumor--A case report (author's transl)].
AB  - A 21-year-old man with nasopharyngeal tumor was  first admitted to the Nagoya
      University Hospital on April 15, 1972. He had difficulty in speaking and
      swallowing, and developed double vision prior to admission. A soft and yellow
      tumor was found in the nasopharynx and revealed typical features of chordoma. The
      patient underwent Co60 irradiation after the operation. On January 25, 1973, the
      patient developed double vision of severe degree. Microscopic examination of the
      specimen which was obtained at the time of the second operation in February 9,
      1973, disclosed a coexistence (collision) of chordoma and hemangioblastoma. The
      two different tumors were situated in juxtaposition on histological examination.
      Co60 irradiation was added during his second hospitalization. Three months after
      the second operation, he developed symptoms of meningitis and was hospitalized
      for the third time on June 3, 1973, at which time the tumor tissue extended
      through the right frontal and middle fossa. The third operation was done with
      frontal craniotomy and tumor was partially removed. The histological diagnosis
      was hemangioblastoma. Postoperatively the patient went downhill and died on
      September 19, 1973. The report of a collision tumor of intracranial chordoma and
      hemangioblastoma is not found in the previous literature. There have been many
      theories as to the origin of collision tumor. Some investigators have proposed
      that the existence of hyperplastic blood vessels within the glioblastoma is
      responsible for the collision tumor of sarcoma and glioblastoma. Since the advent
      of radiotherapy, several examples of sarcoma have been discovered at postmortem
      examination in patient irradiated for treatment of cerebral neoplasm, both
      gliogeneous and nongliogenous, suggesting a possible relationship between the
      tumor and the radiation therapy. In our case, the chordoma showed neither
      hyperplastic blood vessels nor malignant pattern on histological examination. It
      was suspected that post-operative radiation induced the hemangioblastoma. The
      etiology was discussed from the review of literature.

PMID- 1034890
TI  - [Co-existing aneurysm and arteriovenous malformation--case report (author's
      transl)].
AB  - A patient was presented with both an aneurysm of the frontobasal branch of the
      right anterior cerebral artery and an arterio-venous malformation fed by the same
      artery. A 36-year-old man with sudden headache, nausea and vomiting was admitted
      to the emergency clinic on July, 4, 1974. On admission, he was slightly lethargic
      and complained of severe headache. The blood pressure was 112 systolic and 64
      diastolic. He showed no abnormal findings except for nuchal stiffness and bloody
      liquor (pressure 260 mmH2o). A right carotid angiogram revealed an aneurysm, 1.0
      cm in diameter, on the frontabasal branch of the right anterior cerebral artery
      and distal to the aneurysm the artery continued to an arteriovenous malformation.
      No other vascular lesion was observed by other angiographies. On July, 24, 1974,
      the parent artery (frontobasal branch) of the aneurysm was clipped and the part
      of right frontal lobe containing the nidus excisted. The patient's post operative
      course was uneventful.

PMID- 1034891
TI  - [Dermoid tumor in left cerebellum--A case report (author's transl)].
AB  - This paper describes a dermoid tumor which developed in the dorso-lateral area of
      the left cerebellar hemisphere. It is the first to be reported in Japan. The
      patient was a 31 year old female who suffered from severe occipital headaches,
      frequent vomiting and gait disturbances. Neurological findings on admission
      included marked bilateral choked discs, horizontal nystagmus on gaze to the left,
      and poor coordination on the finger to nose test, nose-finger-nose test and and
      heel-shin test on the left side. Left suboccipital craniectomy was performed. A
      tumor was found which displaced the left cerebellum anteromedially and
      inferiorly. The postero-lateral surface of the tumor was adherent to the
      overlying dura matter. It was completely removed and found to be about the size
      of a hen's egg. It contained a yellow, porridge-like substance and short hairs.
      Histological examination of the capsule of the tumor showed stratified squamous
      epithelium and cutaneous structures, such as hair follicles and sebaceous glands.
      The diagnosis was dermoid tumors. We could find as many as 78 cases of the
      posterior fossa dermoids in the literature. In 72 cases (92.4%), the mass existed
      along the midline in the posterior fossa. The dermoids developed in the
      cerebellar hemisphere were reported in only 6 cases (7.6%) including the present
      case. Laterally growing dermoids are considered to be very rare. The pathogenesis
      is discussed and the literature reviewed.

PMID- 1034892
TI  - [Traumatic thrombosis of the internal carotid artery: Report of three cases due
      to head injury with basal skull fracture (author's transl)].
AB  - Three cases of traumatic thrombosis of the internal carotid artery due to head
      injury with basal skull fracture were reported. The mechanism of thrombosis, the
      symptomatologic characteristics and the prognosis were discussed with reference
      to the data in the literature. Four mechanisms by which the condition may be
      produced include; injury to the intrapetrous or cevernous portion of the carotid
      artery during basal skull fracture, injury to the point of emergence of the
      carotid artery from the cavernous sinus as a result of shearing strains suffered
      at the time of injury, a direct blow to the neck or trauma to the paratonsillar
      area by a foreign object carried in the mouth, and stretching of the carotid
      artery by heperextension and lateral flexion of the neck. Secondary symptoms due
      to thrombosis of the carotid artery after an interval develop most commonly from
      twelve to twenty four hours. The prognosis in these patients is mostly poor.
      Therefore, angiography should be performed immediately on any patient suspected
      of having this lesion and treatment should be considered.

PMID- 1034893
TI  - Progesterone action on estrous rhythm in the rat following ventromedial nucleus
      lesions.
AB  - Small bilateral lesions of the hypothalamic ventromedial nucleus (SVMN) were
      produced in 4 day cyclic female Wistar rats by passing a 2 mA cathodic current
      through stereotaxically oriented platinum unipolar electrodes for 7 sec. The 24 h
      lengthening of cycle which occurred in 111 our ot 208 females was shown to depend
      upon lesion placement. Early s.c. injection of 0.75 or 1.5 mg progesterone caused
      24 h cycle prolongation more frequently in SVMN-lesioned females with maintained
      4 day cycles than in 4 day cyclic unoperated, sham VMN-lesioned, or dorsomedial
      nucleus (DMN) lesioned females. This effect proved to be related to lesion
      placement. It was therefore concluded that the VMN is involved in the mechanisms
      whereby progesterone controls estrous cycle duration in the rat.

PMID- 1034894
TI  - The contribution of genetics to biological psychiatry.
AB  - One of the most striking developments in the framework of biological psychiatry,
      is the use of human as well as animal genetics' methodology in psychiatric
      research. After reviewing some basic concepts in human genetic research, we shall
      present the current status of our knowledge on the genetic determinants of the
      major psychoses, i.e., the affective psychoses and schizophrenia. The importance
      of genetic research into psychiatry can also be underscored from a biometric
      point of view in showing its contribution to the clarification of problem of
      nosology in attempting to subclassify abnormal behavior on a more etiological
      basis. Finally, a still open field essential to our comprehension of therapeutics
      emerges from the study of genetic mechanisms involved in drug metabolism and drug
      response.

PMID- 1034895
TI  - [A case of hypertrophic subaortic stenosis associated with true mitral stenosis].

PMID- 1034896
TI  - [Clinical contribution on cholestatic jaundice in pregnancy].

PMID- 1034897
TI  - [A case of cervical pregnancy].

PMID- 1034898
TI  - [Early treatment of vesicovaginal fistulas caused by obstetric injury].

PMID- 1034899
TI  - Aortic prolyl hydroxylase and the development of arteriosclerosis in the female
      breeder rat.
AB  - Female breeder rats develop arteriosclerosis spontaneously. The primary lesions
      seen in the early stages of the disease consist of subintimal and adjacent medial
      ground substance accumulations. With repeated breeding there is extensive
      elastolysis and calcification in the aorta. In aortae with developing arterial
      disease, prolyl hydroxylase activity is elevated as is both aortic protein and
      hydroxyproline, indicative of increased collagen deposition associated with the
      sclerotic degeneration. As the disease becomes very severe, however, prolyl
      hydroxylase activity declines, possibly associated with decreased metabolic
      activity in the severely calcified aorta. Lactation, followed by forced weaning,
      may condition the development or arterial disease through effect on collagen
      metabolism. During the first breeding cycle, aortic prolyl hydroxylase activity
      is elevated for 5 to 10 days after weaning. This increased collagen metabolism in
      the aorta may be a primary event in the development of the advanced calcific
      lesions characteristic of the lesions in breeder rats, and may be affected by
      hormones associated with different phases of the reproductive cycle.

PMID- 1034900
TI  - [Effect of sodium alpha-glycerophosphate on lymphocyte metabolism of fetuses
      during deep hypoxia].

PMID- 1034901
TI  - [Experimental basis for using antihypoxic substances in fetal hypoxia].

PMID- 1034902
TI  - [Changes in the protein metabolism of the myocardium and liver of rats under the
      influence of a toxic dose of alcohol].

PMID- 1034903
TI  - [Rhythms in biological processes].

PMID- 1034904
TI  - [Morphological studies on experimental adhesion of gastric perforations in
      infected surroundings].

PMID- 1034905
TI  - [Cellular immunity in children with idiopathic thrombocytopenic purpura].

PMID- 1034906
TI  - [Diurnal characteristics of aldosteronuria and potassium-sodium balance in
      ketoacidotic coma in children].

PMID- 1034907
TI  - The M. omohyoideus of the mouse as a convenient mammalian muscle preparation.  A
      study of junctional and extrajunctional acetylcholine receptors by noise analysis
      and cooperativity.
AB  - Muscles from cats, rats, guinea pigs and mice have been investigated as
      preparations for visualizing mammalian neuromuscular junctions with the aid of
      Nomarski interference optics. The M. omohyoideus of the mouse was found to be
      most convenient. Electrophysiological investigations showed that an endplate is
      normally surrounded by a population of perijunctional receptors. For junctional
      receptors in the endplate, a Hill coefficient of nH = 2.6 for acetylcholine was
      determined at 38 degrees C, decreasing to a value of 2.3 at room temperature. For
      both perijunctional and extrajunctional receptors (the latter occurring after
      denervation), the coefficient nH was 1.9. Noise analysis revealed a channel
      conductance gamma which changed abruptly from 22.4 +/- 1.0 pS (10--23 degrees C)
      to 45.6 +/- 3.9 pS (34--39 degrees C) in a very small temperature range around
      25.5 degrees C. The mean channel lifetime tau was 0.3 ms at 39 degrees C and 1.0
      ms at 23 degrees C.

PMID- 1034908
TI  - Renal tubular reabsorption of taurine, gamma-aminobutyric acid (GABA) and beta
      alanine studied by continuous microperfusion.
AB  - Renal tubular reabsorption of taurine, gamma-aminobutyric acid (GABA), and beta
      alanine was studied in vivo et situ by continuous microperfusion of single
      proximal tubules of the rat. In each case, reabsorption was much slower than that
      for other amino acids that have been studied. With a concentration of 0.1 mmol/l
      in initial load was reabsorbed over perfusion distance of 3 mm. Taurine
      reabsorption saturated with only 2.17 mmol/l in initial perfusate. Assuming
      simple two-parameter kinetics, upper limits for Km of 0.54 mmol/l and forVmax of
      0.59 pmol-cm-1--s-1 for tubular reabsorption of taurine were estimated. High (20
      mmol/l) concentrations of taurine or beta-alanine in perfusate completely
      inhibited GABA reabsorption, but L-phenylalanine (20 mmol/l) had no significant
      effect. The results indicate that the three amino acids are reabsorbed slowly
      from the proximal tubule by what may be a common transport system. This system
      appears to have a high affinity but low capacity and to be different from other
      known renal tubular transport systems for amino acids.

PMID- 1034909
TI  - The time course of phosphorylcreatine resynthesis during recovery of the
      quadriceps muscle in man.
AB  - The time course of phosphorylcreatine (PC) resynthesis in the human m. quadriceps
      femoris was studied during recovery from exhaustive dynamic exercise and from
      isometric contraction sustained to fatigue. The immediate postexercise muscle PC
      content after either form of exercise was 15-16% of the resting muscle content.
      The time course of PC resynthesis during recovery was biphasic exhibiting a fast
      and slow recovery component. The half-time for the fast component was 21-22s but
      this accounted for a smaller fraction of the total PC restored during recovery
      from the isometric contraction than after the dynamic exercise. The half-time for
      the slow component was in each case more than 170 s. After 2 and 4 min recovery
      the total amount of PC resynthesized after the isometric exercise were
      significantly lower than from the dynamic exercise. Occlusion of the circulation
      of the quadriceps completely abolished the resynthesis of PC. Restoration of
      resynthesis occurred only after release of occlusion.

PMID- 1034910
TI  - Evaluation of a neurogenic rapid coronary dilatation during an excitatory
      response in conscious dogs.
AB  - The present study was undertaken to evaluate the mechanisms of coronary
      adaptation to sudden changes in myocardial oxygen demand that occur during
      excitement. An excitatory response was evoked either by electrical stimulation of
      the hypothalamic defence area or by noise (discharge of a fire-arm). Continuous
      measurement of the oxygen saturation in coronary venous blood was used to judge,
      whether an increase in coronary flow was adequate to match an increased
      myocardial oxygen demand. During the excitatory response heart rate, cardiac
      output and coronary flow increased. However, the increase in coronary flow was
      not adequate to meet the increased metabolic requirement as indicated by a
      decrease in coronary venous oxygen saturation. In dogs with experimental
      atrioventricular block, and with heart rate controlled by external pacing, a
      rapid coronary dilation occurred during the excitatory response and was
      accompanied by an increase in coronary venous oxygen saturation. This rapid
      coronary dilation was abolished by beta-adrenergic blockade. The pattern of
      coronary flow and coronary venous oxygen saturation that occurred during the
      excitatory response in normal dogs could be mimicked in dogs with
      atrioventricular block by increasing the ventricular pacing rate. However, when
      identical increases in heart rate were induced either excitement or by external
      pacing, the drop in coronary venous oxygen saturation was significantly larger in
      the paced series. This demonstrates, that an increase in heart rate is
      responsible for the transient decrease in coronary venous oxygen saturation
      during the excitatory response. From these experiments it is concluded that a
      rapid neurogenic dilation of the coronary vessels occurs during the excitatory
      response. Under normal conditions this rapid neurogenic dilation is masked by the
      effect of the accompanying increase in heart rate on extravascular coronary
      resistance.

PMID- 1034911
TI  - Elimination of vasopressin by the normal and the damaged liver. Experiments on
      unanaesthetized normal and thiocetamide treated rats with a note on the influence
      of ethanol.
AB  - Arginine vasopressin was infused into the V. portae and into the V. cava of
      unanesthetized rats in water diuresis. The differential antidiuretic response of
      the same animal to these infusions was used to calculate extraction fraction of
      ADH by the liver. In the normal rat no extraction was detected. The liver of rats
      hydrated with 5% ethanol extracted 10% and that of rats treated with
      thioacetamide extracted 60% of the ADH infused into the portal vein. It is
      postulated that disturbances of liver cell function by narcotics and substances
      causing liver damage may liberate ADH-destroying ferments into the blood.

PMID- 1034912
TI  - Effects of saline loading on jejunal absorption of calcium, sodium, and water,
      and on parathyroid hormone secretion in the rat.
AB  - To investigate whether intestinal calcium absorption parallels that of sodium
      following extra-cellular fluid volume expansion, the effects of saline loading on
      intestinal transport of calcium, sodium and water were studied in rats by
      perfusing jejunal loops in situ. After calcium-free saline infusion net calcium
      absorption was reversed similar to that of sodium and water and net secretion
      occurred. Concurrently, blood-to-lumen (b-l) calcium flux, measured using 45Ca,
      increased significantly (P less than 0.001). Following expansion with calcium
      containing Ringer a similar reversal of net calcium, sodium and water flux was
      also observed. Again the b-l calicum flux increased but to a significantly lesser
      extent (P less than 0.05). Plasma ionized calcium remained unchanged after
      calcium-rich Ringer loading, but decreased significantly (P less than 0.001) when
      calcium was omitted from the solution. Plasma immunoreactive parathyroid hormone
      unchanged after expansion with the calcium containing solution but increased
      following calcum-free infusion. It is concluded that after extracellular fluid
      volume expansion: 1. net jejunal calcium absorption is decreased; 2. the decrease
      parallels that of sodium and water; 3. b-l calcium transport is enhanced to a
      greater degree of calcium-free Rnger infusion than by a calcium-rich solution.
      This difference could be the result of increased parathyroid hormone secretion.

PMID- 1034913
TI  - Renal urate transport during variations in urate synthesis in the rat.
AB  - In order to determine the effect of intrarenal synthesis of urate upon the
      urinary urate excretion in the rat, we effected large changes in urate synthesis
      by increasing it with allopurinol. Hypoxanthine infusion increased plasma urate
      rapidly and also increased the urinary urate excretion and its renal clearance.
      However, when the plasma urate was maintained constant, hypoxanthine had no
      effect upon renal urate transport. Conversely, allpurinol infusion rapidly
      diminished the plasma urate, urinary urate excretion and its renal clearance.
      Again, the maintenance of a constant plasma urate concentration prevented any
      change in urate transport during allopurinol. The urinary degradative purine
      metabolic pattern was altered predictably by hypoxanthine and allopurinol.
      Assuming than any putative intrarenal component of urate synthesis would be
      affected predictably and consistently by hypoxanthine and allopurinol, these
      results suggest that changes in intrarenal urate synthesis are not an important
      determinant of urate excretion in the rat.

PMID- 1034914
TI  - Fatigue and caffeine effects in fast-twitch and slow-twitch muscles of the mouse.
AB  - In excised, curarized and massively stimulated fast-twitch mouse gastrocnemius
      muscles the early twitch tension enhancements (treppe) during 1/s activity
      between 10 and 36 degrees C increase and affect more contractions as temperature
      increases. Tension output eventually declines at a temperature-independent rate.
      Half-relaxation time lengthens below 25 degrees C and shortens above 25 degrees
      C. During 1/0.63s twitches half-relaxation time lengthens even at 25 degrees C.
      In slow-twitch soleus muscles activity decreases twitch tension and half
      relaxation time regardless of temperature. Activity shortens contraction times in
      both muscles. Oxygen lack induced by NaN3 cannot account satisfactorily for these
      results. Activation is apparently more plastic in the gastrocnemius than in the
      soleus, and the relationship between the rates of their activation and relaxation
      processes and the temperature sensitivities of these rates also seem to differ.
      In both muscles caffeine can convert activity-induced shortened of half
      relaxation times into prolongations. In the soleus this effect is more pronounced
      at 30 than at 25 degrees C. At high temperature and twitch rates caffeine reduces
      treppe amplitude and duration without affecting the eventual twitch tension
      decline in the gastrocnemius while it greatly accelerates twitch tension decline
      in the soleus. In both muscles intrafiber Ca2+ movements are apparently major
      determinants of fatigue behavior.

PMID- 1034915
TI  - A continuous-flow, variable mixing valve for perfusion experiments.
AB  - The device described here continuously mixes two solutions in any required ratio
      and has been used at flow rates of 6 ml/min in tissue perfusion experiments. Its
      low-cost construction consists of a three-way miniature solenoid valve driven by
      a simple electronic circuit. Mixing is stable, reproducible and accurate to +/-
      1% of dial setting.

PMID- 1034916
TI  - Prophylactic, postinfectious and neonatal vaccination against canine distemper in
      mink.
AB  - Mink were vaccinated against canine distemper and challenged with the Snyder Hill
      strain of canine distemper virus. Protection was acquired if vaccination took
      place more than a few days before challenge. If vaccination took place even early
      during incubation mortality was higher than in the unvaccinated controls. Full
      protection of kits may be achieved even at an age of 16 to 20 days provided the
      kits had not passively acquired immunity from their mothers. Kits surviving
      distemper because of passively acquired immunity may not actively acquire
      immunity during infection and may die at a later exposure.

PMID- 1034917
TI  - [The receptor of adenosine-dephosphate on the human platelet membrane (author's
      translation)].
AB  - The binding of 14C-ADP on the isolated platelet membrane is a saturable and
      reversible phenomenon which seems to implicate a protein only partially
      solubilised by Triton X-100. The binding is strongly reduced by mersalyl, which
      is known to inhibit the ATPase activity of the thrombosthenin i.e. the platelet
      contractile protein; this protein could be involved in the mechanism of binding
      of ADP on the platelet membrane. Platelets not aggregated by ADP from patients
      with Glanzmann's thrombasthenia, have a normal binding of 14C-ADP which is also
      strongly reduced by mersalyl.

PMID- 1034918
TI  - [Clinics and genetics of Glanzmann's thrombasthenia (author's translation)].
AB  - Glanzmann's thrombasthenia begins in infancy. The most important clinical signs
      are cutaneous and mucous hemorraghes (purpura, epistaxis, bleeding gums,
      menorraghia after puberty). The disease proceedes by alternate periods of
      activity and remission, the frequency and severity of which decrease with age.
      Death occurred during any of the attachs. Our 10 cases (7 girls, 3 boys) were in
      5 "Manouche" gypsies sibships, interrelated by consanguineous marriages. Genetic
      studies demonstrated that the disease was inherited in the autosomal recessive
      pattern. The detection of heterozygotes is now possible with an antibody which
      appeared in a thrombasthenic patient. This antibody agglutinated the normal
      platelets, but not the ones of thrombasthenic patients. In heterozygotes the
      agglutinating effects is intermediate between the homozygote and normal.

PMID- 1034919
TI  - Spectrum of pharmacological actions on brain dopamine. Indications for
      development of new psychoactive drugs. Discussion of amantadines as examples of
      new drugs with special actions on dopamine systems.
AB  - Amantadine (D1) and 1,3-dimethyl-5-aminoadamantane (D145) as examples of new
      drugs with special actions on dopamine systems are discussed. D1 or D145
      decreased significantly apomorphine or amphetamine-induced stereotypy in rats but
      in experiments with chronic pretreatment with amantadines -- potentiation of
      stereotypy was observed. D145 (20 mg/kg) abolished stereotypy in these
      conditions. In biochemical experiments D1 or D145 were neither like apomorphine
      nor like amphetamine. Its concluded that D1 and D145 in addition to their amine
      releasing properties have the ability partially to occupy the dopaminergic
      receptor.

PMID- 1034920
TI  - Central action of ergometrine.
AB  - Ergometrine, a spasmolytic which also stimulates dopamine receptors, was
      investigated as a potential central stimulant. It did not influence the locomotor
      activity of normal rats and mice, and in high doses even depressed it. The
      locomotor activity depressed by reserpine, spiroperidol, and pimozide was
      elevated by ergometrine. Ergometrine antagonized neuroleptic-induced catalepsy
      and abolished ptosis and hypothermia produced by reserpine. Given alone
      ergometrine depressed the body temperature in rats and mice, and this effect was
      abolished by pimozide in both species, and by spiroperidol and haloperidol in
      mice. The hypothermia was not antagonized by atropine. In several respects the
      central action of ergometrine resembles that of apomorphine.

PMID- 1034921
TI  - The effect of theophylline and caffeine on neuroleptic-induced catalepsy.

PMID- 1034922
TI  - Effects of pyrazolone-5 derivatives on amphetamine-induced hyperthermia and
      behavioural changes in rats.

PMID- 1034923
TI  - Hexobarbital sleeping time in the rat: effects of isolation and lesions of the
      locus coeruleus.
AB  - Hexobarbital sleeping time was observed in isolated and nonisolated rats with
      lesioned locus coeruleus (LC). Isolated animals were divided into 2 groups:
      aggressive (killers) and indifferent (nonkillers). Each group included rats with
      no lesion, with sham lesion and with LC lesion. Hexobarbital sleeping time was
      prolonged in nonisolated male, but not female, rats with lesioned LC (7 and 14
      days after the lesion). This effect was not observed in animals previously
      isolated for 3 weeks. These results suggest that the LC plays an important role
      in the mechanisms of barbiturate sleep, but this effect may be related to the
      emotionality of animals.

PMID- 1034924
TI  - Effect of angiotensin on the central action of dopamine.
AB  - Angiotensin given intraventricularly enhances amphetamine but not apomorphine
      induced stereotypy 30 min. after peptide administration. Simultaneous injection
      of angiotensin and dopamine increases amphetamine -- while decreases apomorphine 
      - induced stereotypy. The stereotypy produced either by apomorphine or
      amphetamine in rats pretreated with Ro 4-4602 + L-DOPA was diminished by
      angiotensin. Angiotensin elevated haloperidol-induced catalepsy. A possibility
      that angiotensin may inhibit both release and uptake of dopamine by nerve endings
      is discussed.

PMID- 1034925
TI  - The effect of bradykinin on central dopamine receptors.
AB  - Bradykinin (BK) injected intraventricularly (ivc) at doses of 0.25-0.5 mug per
      rat potentiated the depth of fluphenazine catalepsy and depressed or abolished
      the symptoms of sterotypy produced by amphetamine or apomorphine. BK did not
      affect the level of dopamine (DA), but elevated the level of homovanillic acid in
      the brain, and accelerated DA turnover as measured by the rate of dopamine
      disappearance following treatment with alpha-methyltyrosine. The results suggest
      that BK inhibits the central dopamine structures by blocking the DA receptors.

PMID- 1034926
TI  - Influence of albumin degradation products (ADP) on the central action of
      catecholamines.
AB  - The influence of ADP on the central action of catecholamines was investigated.
      ADP abolished the central action of noradrenaline, amphetamine and nialamide. The
      peptides decreased apomorphine stereotypy and enhanced haloperidol induced
      catalepsy. These results support our previous suggestions [10-14] that ADP acts
      on the CNS by antagonizing the action of central catecholamines.

PMID- 1034927
TI  - Hypertension in pregnancy.

PMID- 1034928
TI  - Clinical applications of 24 hour electrocardiogram recordings.

PMID- 1034929
TI  - [Pickwickian syndrome and hypersomnia with periodic respiration].
AB  - A classical definition of Pickwickian syndrome associates alveolar
      hypoventilation, obesity and hypersomnia with periodic breathing. Obesity in
      itself is enough to explain the alveolar hypoventilation and some of the sleep
      disorders, but in fact all three elements of this syndrome are intricated.
      Obesity, whether associated with a Pickwickian syndrome or not, affects
      ventilatory mechanics similarly. With the cause of sleep disorders are associated
      central ventilatory pauses, appearing periodically followed by phases of apnoea
      secondary to buccopharyngial hypotony. The alveolar hypoventilation is therefore
      the consequence of obesity and periodic apnoea. It also results from a low
      respiratory frequency considering that the tidal volume is also decreased. These
      different elements suggest some disorder of the centers controling ventilation.
      One can describe different nosological forms, all having as a common factor
      hypersomnia with periodic respiration, the latter being a determining factor in
      the diagnosis. Therapy, including weight reduction and symptomatic treatment of
      alveolar hypoventilation, is now augmented by new drugs acting on the central
      nervous system.

PMID- 1034930
TI  - [Is the splenectomy patient permanently disabled? A poll of the experts in the
      field (author's transl)].

PMID- 1034931
TI  - Tissue culture of rat lenses.

PMID- 1034932
TI  - Effect of pinealectomy and of bilateral cervical ganglionectomy on serum LH
      levels in constant estrous-anovulatory rats.

PMID- 1034933
TI  - Inhibition of interferon action by cytochalasin B, colchicine, and vinblastine.

PMID- 1034934
TI  - Interferon assay of high sensitivity.

PMID- 1034935
TI  - Hormones and regional brain blood flow.
AB  - Acute effects of the hormones, estradiol-17beta and alphaMSH, and of neonatal
      pretreatment with alphaMSH on the flow of blood to regions of the brains of
      conscious adult rats have been determined with an indicator distribution
      technique. As previously reported, flows were reduced in most areas within 10 min
      after intravenous administration of alphaMSH; only the occipital cortex was
      spared. Though these effects were transitroy for most areas, perfusion of pons
      and medulla, cerebellum, hippocampus and parietal cortex was still low by 20 min.
      However, pretreatment with alphaMSH during infancy led to persistent behavioral
      changes which were not accompanied by flow differences. Assuming that flow
      changes reflect functional changes, the rapid responses to alphaMSH suggest an
      explanation for the effects of this hormone on visual learning and on the
      determination of subsequent learning behavior. By contrast, estradiol, within 10
      min after injection, increased flow to most regions of the brain, especially the
      frontal cortex, hippocampus, basal ganglia and cerebellum; females were more
      affected than males. Flow changes were greater than those elicited by more
      obvious behavior-modifying drugs. Compared to alphaMSH, the flow data for
      estradiol suggest a physiologic basis for a behavioral effect which is likely to
      be different yet, perhaps, equally profound.

PMID- 1034936
TI  - Effects of monoolein on hydrolysis of triglyceride by lipoprotein lipase in the
      presence of an inhibitory apolipoprotein.
AB  - The previously demonstrated inhibition of cow's milk lipoprotein lipase by apoLp
      Ala and the deinhibition by monoglyceride have been studied in more detail. The
      apoLp-Ala inhibition is reversible by the addition of monoglyceride before or
      after enzyme additions. Quantities of monoglyceride accumulate during hydrolysis
      of triglyceride which are adequate to prevent inhibition by added apoLp-Ala.
      Accelerating reaction rates observed when the substrate contains the apoprotein
      at levels producing partial inhibition are also explained by monoglyceride
      production. These effects were observed with both crude preparations of skim milk
      and highly pruified lipase. It is suggested that the generation of monoglyceride
      may be important in facilitating hydrolysis of triglyceride in lipoproteins
      containing this inhibitory apolipoprotein.

PMID- 1034937
TI  - Gonadal hormones and body temperature in rats: effects of estrous cycles,
      castration and steroid replacement.

PMID- 1034938
TI  - [Amygdaloid control over interspecies and shock-induced aggression in the rat
      (author's transl)].

PMID- 1034939
TI  - [Effects of septal lesions on the behavior of amygdalectomized rats towards mice
      (author's transl)].

PMID- 1034940
TI  - Progesterone: examination of its postulated inhibitory actions on lordosis during
      the rat estrous cycle.

PMID- 1034941
TI  - Medial preoptic and anterior hypothalamic lesions: influences on aggressive
      behavior in female hamsters.

PMID- 1034942
TI  - Placentophagia in nonpregnant rats: influence of estrous cycle stage and
      birthplace.

PMID- 1034943
TI  - Behavioral disturbances in a two-way shuttle-box in congenitally jaundiced Gunn
      rats.

PMID- 1034944
TI  - Poison induced pica in rats.

PMID- 1034945
TI  - Effects of genital stimulation upon spinal reflex activity of female cats under
      various hormonal conditions.

PMID- 1034946
TI  - Intruder gonadectomy and elicitation of territorial aggression in the rat.

PMID- 1034947
TI  - Effect of neonatal surgery on adult fighting and spacing in mice (Mus musculus).

PMID- 1034948
TI  - Intellectual differences in relation to personal and family handedness.

PMID- 1034949
TI  - The state of medicinal science.

PMID- 1034950
TI  - [Topics on interferon--general preface (author's transl)].

PMID- 1034951
TI  - [Problems on "interferon" as a medicine: -- a view point of an investigatar
      participating in its developement-- (author's transl)].

PMID- 1034952
TI  - [Short history of SDS-polyacrylamide gel electrophoresis (author's transl)].

PMID- 1034953
TI  - [Upconversion light reaction in photosynthesis and solar conversion (author's
      transl)].

PMID- 1034954
TI  - [Oxidative enzymes of acetaldehyde in the liver : their characteristics and
      effect of chronic ethanol consumption on the acetaldehyde metabolism (author's
      transl)].

PMID- 1034955
TI  - [SDS gel electrophoresis of dansylated proteins and peptides (author's transl)].

PMID- 1034956
TI  - [8 months of experience of the control program of cervicouterine cancer in the
      Southwestern region of Santiago].

PMID- 1034957
TI  - [Evaluation of the regional program od cervical cancer prevention in the 7th
      region, 1974-1975].

PMID- 1034958
TI  - [Evaluation of the control program of cervicouterine cancer in the 8th region].

PMID- 1034959
TI  - [Cone biopsy of the cervix uteri in cervix neoplasms].

PMID- 1034960
TI  - [Morphology and functions - alveolar epithelium of the lung].

PMID- 1034961
TI  - [Blood flow theory and the development of cardiac anomalies (author's transl)].

PMID- 1034962
TI  - [Evaluation of the systolic time interval (2). Changes of the left ventricular
      ejection time].

PMID- 1034963
TI  - [Mechanism of paroxysmal supraventricular tachycardia (I) (author's transl)].

PMID- 1034964
TI  - [Treatment of tachyarrhythmia associated with Wolff-Parkinson-White syndrome].

PMID- 1034966
TI  - [Direct writing vectorcardiography (author's transl)].

PMID- 1034965
TI  - [Mitral valve prolapse syndrome (author's transl)].

PMID- 1034967
TI  - [Study of respiration physiology and clinical practice. (8). Ternary gas
      diffusion].

PMID- 1034968
TI  - [Upper abdominal surgery and respiratory functions (author's transl)].

PMID- 1034969
TI  - [Pulmonary microembolism following massive transfusion of stored blood (author's
      transl)].

PMID- 1034970
TI  - [Experimental intra-His bundle block following ligation of the anterior septal
      artery in dogs (author's transl)].

PMID- 1034971
TI  - [The electroencephalogram in patients with bradyarrhythmias and its changes after
      cardiac pacing (author's transl)]?91H.

PMID- 1034972
TI  - [Variability in the treatment of congestive heart failure].

PMID- 1034973
TI  - [Gas exchange and FRC (author's transl)].

PMID- 1034974
TI  - [Cardiogenic shock (II). Involvement of hypotensive pressoreceptor stretch reflex
      of the heart].

PMID- 1034975
TI  - [Electrical axis (authors transl)].

PMID- 1034976
TI  - [Analytical methods of gases. (2). Analysis of gas samples (author's transl)].

PMID- 1034977
TI  - [Evaluation of cardiac function with radiosiotope (author's transl)].

PMID- 1034978
TI  - [Exercise-induced asthma (author's transl)].

PMID- 1034979
TI  - [Evaluation of training effect on maximal oxygen intake (author's transl)].

PMID- 1034980
TI  - [Ventricular distensibility].

PMID- 1034981
TI  - [Volumetric study of respiration by a low frequency sound (author's trransl)].

PMID- 1034982
TI  - [Juvenile angina pectoris--an autopsy case (author's transl].

PMID- 1034983
TI  - [Infantile psychosis and deafness].

PMID- 1034984
TI  - Study of pineal regulation mechanism in genital development--influence of light
      and drugs on genital organs.

PMID- 1034985
TI  - A simple method for counting antibody bound labelled steroids.
AB  - A simple method is described for the counting of tritiated antibody-bound steroid
      after acidification and extraction into a toluene based scintillant. The
      resulting count rate is stable and quenching is minimal. The method give improved
      count rates when compared with methods employing scintillants containing
      methanol, dioxane, or Triton and compares favourably with methods involving pre
      heating of antibody-bound steroid or extraction of free steroids after the
      addition of ammonium sulphate. A specific antibody for estradiol has been used to
      illustrate the application of the technique to antibody titration curves and
      standard curves.

PMID- 1034986
TI  - O-(Carboxymethyl)oxime steroidal haptens linked in the C3 position: study of the
      characteristics of antibodies against 17alpha-hydroxyprogesterone and
      testosterone and of their evolution with time.
AB  - The production of highly sensitive and specific antisera against 17alpha
      hydroxyprogesterone (17 OHP) is reported. 17 OHP was rendered antigenic by
      covalent linkage to bovine serum albumin through position 3 of the steroid. An
      unambiguous method to prepare the mono-3-0-(carboxy-methyl) oxime derivative
      (CMO) of 17 OHP is described starting from 17 OHP-acetate. Antisera raised in
      rabbits were of high affinity for 17 OHP (Ka = 1 to 2 x 10(10) L/mole) and showed
      very little (less than 0.7%) or no cross reaction with a variety of steroids.
      Cross-reaction with 17alpha-hydroxy pregnenolone was however significant. When
      studied in relation to time, cross-reaction of the latter steroid decreased
      significantly (18 to 2%) while Ka remained at the same level. The same study of
      the evolution with time (up to 600 days) of the characteristics of antisera
      raised against the 3 CMO derivative of testosterone is also reported.

PMID- 1034987
TI  - [Protein SH-group concentration and RNA synthesis during the process of induction
      of proliferation in the stationary phase of cell culture growth].
AB  - The dynamics of intracellular protein SH-group (PSH) content was studied
      cytochemically in the course of stimulation of cell proliferation in stationary
      cultures of an established Chinese hamster cell line and of human diploid embryo
      fibroblasts. The results were compared with the pattern of RNA synthesis during
      the prereplicative period. In Chinese hamster cells immediately after medium
      changing in stationary cultures there is an augmentation of PSH content in
      parallel withe the increase in RNA synthesis rate. Later on, the rate of RNA
      synthesis and PSH content are seen decreasing followed by a new increase in the
      rate of RNA synthesis correlated with the second rise in PSH content. In
      stationary cultures of human diploid fibroblasts, there is also an increase in
      the rate of RNA synthesis and in the content of SH after medium changing, but the
      second wave of RNA synthesis and the second rise in PSH content are not
      pronounced. The variation in PSH content reflects the shift in the cell
      metabolism during the prereplicative period and is not attributed to changes in
      cell protein content.

PMID- 1034988
TI  - [Changes in the cytochemical properties of chromatin after stimulating
      proliferation in a stationary culture of Chinese hamster cells].
AB  - The first part of the prereplicative period in stimulated for cell proliferation
      steady-state culture of Chinese hamster cells was studied cytochemically.
      Investigation of the binding pattern of basic dye Acridine orange and Actinomycin
      D with cell nuclei and the melting profile of chromatin in situ suggests that one
      of the early events occurring in the course of stimulation of cell proliferation
      in steady-state culture is chromatin activation, i.e. changes in its
      physicochemical properties resulting in augmentation of transcription.

PMID- 1034989
TI  - [Analysis of total lactate dehydrogenase isoenzyme activity in mouse ova during
      clevage].
AB  - The total activity of lactate dehydrogenase isoenzymes was detected in the intact
      ova of mice during the clevage and, in particular, blastomeres at the 2-cell
      stage. Routine histochemical technique was employed in addition to
      microspectrometry. During the clevage, the ova differ in their enzyme activity.
      At the 2-cell stage there are ova with similar reaction in both the blastomeres
      as well as those with different enzyme activity in each blastomere.

PMID- 1034990
TI  - The importance of gonadothropin assays in the clinical follow up patients with
      germinal tumors of the testis.
AB  - Clinical-hormone studied were done on 34 patients with germinal tumors of the
      testis. The gonadotropin titres varied from normal to highly elevated values.
      Only in 4 cases (11.77%), however, were the gonadotropin titres above 10,000
      mouse units/24 hours. These 4 were among the 9 cases (26.47%) with positive
      pregnancy tests. Gynaecomastia was present in 4 patients (11.77%). Total
      estrogens were assayed in these 4 cases and were found to be high. Gynaecomastia
      is attributed to excess estrogens. Elevated gonadotropin titres were found
      predominantly in cases of embryonal carcinoma, teratocarcinoma and
      choriocarcinoma, as well as in the most advanced clinical stages. As regards the
      correlation between gonadotropin titres and course of the tumor, it was found
      that the higher the titre the worse the prognosis. The results suggest that
      hormonal assays are of value in the clinical follow-up of testicular germinal
      tumors and should therefore be carried out in association with other clinical
      parameters.

PMID- 1034991
TI  - [Ability of bovine fibrinogen to accept and retain plasminogen proactivator
      specific for human blood].
AB  - The plasminogen proactivator present in human plasma and retained by purified
      human fibrinogen preparations is readily accepted and retained by bovine
      fibrinogen. This "transplantation" makes isolated bovine fibrinogen susceptible
      to streptokinase. The latter induces degradation of isolated bovine fibrinogen
      resulting in characteristic fragment formation. Our experimental results,
      particularly those showing the inability of bovine plasminogen (applied in a
      great excess) to remove the acquired proactivator from bovine fibrinogen, give
      indirect evidence that the proactivator function is not a specific property of
      the human plasminogen but that of some other substance.

PMID- 1034992
TI  - Parkinsonism and neurogenic bladder. Experimental and clinical observations.
AB  - In a group of patients suffering from Parkinson's disease, beside neurogenic
      bladder dysfunction, we have also found dysfunction affecting the external
      sphincter musculature. Treatment with L-Dopa probably improves the urethral
      symptoms by providing a relaxing effect on the urethral closure pressur together
      with better coordination of the pelvic floor and external sphincter Mechanism
      during micturition. The effect was parallel to the improvement in Parkinsonion
      symptoms. Experimental studies demonstrate the ability of L-Dopa to reduce
      urethral closure pressure and this effect was related to a central effect on the
      skeletal musculature.

PMID- 1034993
TI  - [Use of argon laser for treatment of patients with herpetic keratitis].

PMID- 1034994
TI  - [Lasers in the treatment of arterial occlusive diseases of the limbs].
AB  - The authors have analysed the initial results of treatment in 64 patients
      suffering obliterating diseases of arteries of upper and lower extremities by
      means of irradiation with a helium-neon laser the least electric resistance
      points. The control over the results of treatment is exercised basing on findings
      of thermovision study and patients' subjective sensations. The best results were
      gained in treatment of patients with Reynaud diseases and obliterating
      endarteritis. The therapy employed yielded an insignificant effect in various
      forms of atherosclerosis of the lower extremities.

PMID- 1034995
TI  - Oestrous behaviour in a herd of dairy cows.
AB  - A group of 60 housed Friesian cows were observed continuously for a period of 25
      days, during which time all cows were recorded for incidence of mounting activity
      and 18 selected cows were recorded for various aspects of maintenance activity.
      All 60 cows were judged as showing oestrus. Average duration of oestrus (+/-SD)
      in 33 cows was 14-9 +/- 4-7 hours, and the cows were mounted 56-3 +/- 34-8 times.
      The greatest mounting activity was associated with the night hours. There was no
      diurnal pattern of onset of oestrus. The majority of mounting activity (79 per
      cent) occurred in the cubicle area of the building. Comparison of maintenance
      activities showed that oestrous cows spent, on average, less time standing in a
      cubicle (P less than 0-01), lying in a cubicle (P less than 0-001) and more time
      standing elsewhere (P less than 0-001) than non-oestrous cows. The results are
      discussed in relation to oestrus detection.

PMID- 1034996
TI  - Effect of lactation on the immune response to gastrointestinal nematodes.
AB  - The immune expulsion of gastrointestinal nematodes is impaired during lactation
      by the inhibition of the lymphocyte mediated component. As a result the
      population of worms may increase. At the same time, the fecundity of female worms
      in previously immune hosts may increase to approach that of worms in fully
      susceptible animals. There is good evidence that these events are primarily
      endocrinal in origin but although prolactin is probably involved, certain
      anomalies exist. These may reflect differences in the secretion pattern of the
      hormone in different phases of reproduction or they may indicate an
      interrelationship with a second hormone, for instance, adrenal glucocorticoids.

PMID- 1034997
TI  - [For a healthy herd].

PMID- 1034998
TI  - [Epizootiological districting in the planning of antiepizootic measures].

PMID- 1034999
TI  - [Veterinary fluorographic apparatus].

PMID- 1035000
TI  - [A single syringe for cavitary fangotherapy].

PMID- 1035001
TI  - [Change in the adrenocortical function of the adrenals and activity of several
      intracellular enzymes involved in nitrogen metabolism in experimental
      hypothermia].
AB  - An increased content of adrenaline was observed in rabbit adrenal glands under
      the conditions leading to a decrease of rectal temperature. At the same time the
      activities of aspartate- and alanine aminotransferases in liver hyaloplasm and
      ornithine carbamoyl-transferase in mitochondria were decreased, while the
      activity of the transaminases in mitochondria was maintained unaltered. After the
      recovery of the temperature the content of the hormone still exceeded the normal
      level; function of the enzymes studied was distinctly intensified in all the
      subcellular fractions of hepatocyte. Content of 11-hydrocorticosteroid, being
      unaltered distinctly in overcooling, was markedly decreased within the later
      period. Membrane and substrate interrelations, apparently responsible for the
      biochemical alterations observed, are discussed.

PMID- 1035002
TI  - [Creatine biosynthesis in mice with hereditary muscular dystrophy: possible
      defect in liver plasma membrane adenyl cyclase].
AB  - Activity of enzymes responsible for creatine biosynthesis (transamidinase, EC
      2.1.4.1., and guanidine acetate methyltransferase, EC 2.1.1.2.) was studied in
      homogenates of pancreas, kidney and liver tissue of mice in normal state and in
      hereditary muscle dystrophy (129/Re-dy). Simultaneously, the activity of
      guanidine acetate methyltransferase from liver tissue was studied after addition
      of glucagon and ardenaline. In normal healthy mice homogenates of liver tissue
      distinctly increased the activity of guanidine acetate methyltransferase if
      glucagon and adrenaline were used in physiological concentrations. At the
      advanced stage of mice hereditary myodystrophy liver homogenates lost their
      capacity to activate the enzyme after addition of the hormones. The data obtained
      suggest that adenyl cyclase is impaired in plasmatic membranes of liver tissue,
      which mediated, using cAMP,the transformation of hormonal signals affecting the
      intracellular synthesis of creatine.

PMID- 1035003
TI  - [Transplacental blastomogenic effect of N-nitrosomethylurea in rats with constant
      estrus].
AB  - As a result of transplacental exposure of rats of NMU in the dosage of 20 mg/Kg
      (intraperitoneally) on the 21st day of pregnancy tumors in the offspring
      developed in 6 to 16 females and in 10 of 17 males. In rats with persistent
      estrus, induced in sex mature females by their castration and one-moment
      autoimplantation of ovaries in the tail, tumour developed in 25 of 41 animals. In
      combination of transplacental effect of NMU and postnatal induction of persistent
      estrus in females neoplasms were recorded in 14 of 17 animals, the incidence of
      neoplasms of the nervous system and kidney observed only after transplacental NMU
      exposure of males being increased. Hormonalmetabolic shifts observed in rats with
      persistent estrus seemed to potentiate transplacental blastomogenic action of
      NMU.

PMID- 1035004
TI  - [State of nerve fibers of major nerve trunks of the extremities in alcoholic
      intoxication].

PMID- 1035005
TI  - [Familial factors in coronary disease].

PMID- 1035006
TI  - Erysipelothrix insidiosa endocarditis. A report of two cases in Jamaica.

PMID- 1035007
TI  - [Present-day prospects for using parasites in the fight against mollusca, vectors
      of human bilharziasis].

PMID- 1035008
TI  - [Epideniological problems posed by vector-transmitted diseases in African dense
      forest zones: effects of environmental changes].

PMID- 1035009
TI  - [Fungus infections in the genital-crural region in andrological patients
      (proceedings)].

PMID- 1035010
TI  - [Possibility of regulation of the immunologic activity of the lymphoid system by
      thymus gland factors. III. Morpho-histochemical characteristics of different
      lymphoid formations of puppies stimulated by thymus humoral factor].

PMID- 1035011
TI  - [Effect of group and isolated rearing of white rats on their resistance to
      exposure to emotional stress].
AB  - The influence of isolated vs. group breeding on the sensitivity of higher nervous
      and vegetative functions to chronic stress effects was studied in 50 albino
      random-bred male rats. It has been found that group breeding of the animals (ten
      specimens in each cage) from the 12th to the 30th week of their life enhances
      their resistance to external stress factors which begin to take effect from the
      17th week on. The effect is linked to the positive emotions produced by mutual
      contacts among the animals and their intensified motor activity. Isolated
      breeding of the rats (beginning with the 17th week of their life) makes them
      vulnerable to the action of stress situations. By the end of the investigation
      they exhibit clear symptoms of an early stage of neurogenic hypertension. The
      isolation evidently sets up a negative emotional background, reduces drastically
      the motor activity and lowers the animals resistance to extreme environmental
      influences.

PMID- 1035012
TI  - [Anatomy, topography, size and weight of the female genitalia in Meriones
      unguiculatus].

PMID- 1035013
TI  - [Extracorporeal ileocecal bypass avoiding the ileocecal value in swine].

PMID- 1035014
TI  - [The challenge of world infectious diseases since 1945 in Middle Europe (author's
      transl)].

PMID- 1035015
TI  - [Notifiable and non-notifiable infectious diseases in the federal republic of
      germany (author's transl)].
AB  - Owing to the growing density of population, urbanization, and the use of all
      kinds of publicly accessible facilities, the interruption of the infection chain
      for air-borne diseases proves particularly inadequate if no efficient
      prophylactic inoculations are available to combat viral infections or if no
      efficient chemotherapeutical measures can be adopted against bacterial
      infections. Equally problematic is the struggle against salmonellosis associated
      with the mechanized mass production and distribution of foodstuffs as well as the
      forms of infectious hospitalism, especially hepatitis B, which are favoured by
      the technical advances in the medical field. Venereal diseases prove highly
      resistant because the human patterns of sexual behaviour are difficult to
      influence. Thus the infectious diseases caused by deficient hygiene have
      virtually disappeared in our country, while those diseases survive or occur which
      are capable of profiting from the sociological changes and the technical progress
      of civilisation. On the whole, the mortality rate has drastically dropped while
      morbidity has remained more or less the same (with, however, a change in the
      spectrum of the infectious diseases); this is due mainly to mass inoculation and
      specific therapy.

PMID- 1035016
TI  - [New topics in infectious medicine (author's transl)].
AB  - After the eradication and control of the old classical epidemics, the situation
      in the sector of infectious diseases has changed. These days 3 groups of
      infectious diseases have gained importance than they had in the past and thus
      have changed the scene: I. Infectious diseases which earlier were either not
      known on such a scale or completely unknown Under this group fall mainly the
      "infectious factor diseases" caused by so-called "opportunistic" germs, mixed
      infections, old and new zoonoses, iatrogenic infections, "explosion epidemics"
      and epidemics caused by germ mutations. II. Therapy-resistant infectious diseases
      Here a distinction is made between infectious diseases caused by chemotherapy
      resistant germs and the diseases whose increased rate of incidence is due to the
      fact that the arthropod vectors became resistant to insecticides. III. Infectious
      diseases to which the classical Henle-Koch postulates no longer apply These are
      chronic diseases and persistent infections, immunopathogenic consequences of
      infections and viral tumours. The diseases are discussed separately with respect
      to the cause/effect relationship with the emphasis on the following subjects:
      Opportunistic problem germs, infectious factor diseases with hospitalism, mixed
      infections, salmonellosis and new viral zoonoses, chronic diseases, "slow
      viruses", immunopathogenic consequences of infections and viral tumours.

PMID- 1035017
TI  - [Immunologic response ot introduction of intact and formalinized erythrocytes].
AB  - Experiments were conducted on mice; there was revealed an increase in the
      immunogenicity of erythrocytes following their immunization illustrated by the
      difference in the circulating antibody titres and the plaque count in the spleen
      of the animals, and also by the results of immunization with formalin-treated
      erythrocytes mixed with the cells of the peritoneal exudate. A conclusion was
      drawn on the expediency of the immunization with formalinized erythrocytes of
      rabbits--producers of the hemolytic serum.

PMID- 1035018
TI  - [Hypnosis as an artificially evoked individual psychological defense (clinical
      study of hysterical and psychasthenic unconscious mechanisms in hypnosis and in
      stress situations)].

PMID- 1035019
TI  - Effect of sodium fluoride on glycolysis in human erythrocytes and Ehrlich ascites
      tumour cells in vitro.
AB  - In human erythrocytes and Ehrlich ascites tumour cells, NaF inhibites aerobic
      glucose utilization and lactate formation. The inhibition of glycolysis was
      accompanied by a decrease in cellular pyruvate and ATP, and by accumulation of 2
      hosphoenolpyruvate. These results and direct enzymatic determinations showed that
      fluoride inhibits, in addition to enolase (phosphopyruvate hydratase, EC
      4.2.1.11), also pyruvate kinase.

PMID- 1035020
TI  - [Glucose tolerance of postnatally stress-sensitized albino rats following chronic
      emotional stress in adulthood].
AB  - Male albino rats were used to study the effect of electrical stimulation in the
      postnatal phase (day 1--15) leading to short-time convulsions and cyanosis
      lasting about 10 min in 5-month-old animals upon the development of glycemic
      dysregulation induced by emotional stress. The studies involving i.p. glucose
      administration show that a 3-week stress influence on postnatally stimulated
      animals caused heavier changes of glycemic regulation than with non-pretreated
      animals. These results suggest a stress sensitization occurring in the postnatal
      phase and are discussed in connection with the "stress-sensitive risk
      personality" by R. BAUMANN. Further studies have shown that the postnatal stress
      sensitiveness is reversible and cannot only be compensated by a rest period of
      several weeks but may even cause stress resistance on renewed stressing for three
      weeks.

PMID- 1035021
TI  - [The role of uncertainty in the conditioned-reflex learning behavior for selected
      cardiovascular functions].
AB  - As a contribution to quantitative analysis of exogenous stress action, the role
      of probability learning (probability stress, probability affirmation) for
      selected cardio-vascular functions was studied in 25 albino rats and 8 dogs. It
      has been shown in the rats learning with probability stress that a dependence
      exists between stress probability, on the one hand, and conditional-reflectory
      processes and systolic blood pressure rise, on the other, that is, the pathogenic
      action of probability stress increases from a probability of p = 1.0 to p = 0.5.
      An analogous picture was found with the probability affirmation being applied in
      dogs. While a probability affirmation with p = 1.0 promoted adaptational
      processes, a value of p = 0.5 led to experimental neurosis, tachycardia and ECG
      alterations. The results obtained are discussed in context with the information
      entropy and information theory of emotions.

PMID- 1035022
TI  - [Determination of postmortem time lapse, with special reference to the inorganic
      phosphorus content in the aqueous humor of man].

PMID- 1035023
TI  - [Management of patients with low estriol levels at our hospital].

PMID- 1035024
TI  - [Clinical studies of solid ovarian tumor: ovarian sarcoma].

PMID- 1035025
TI  - [Clinical studies of solid ovarian tumor: Brenner tumor].

PMID- 1035026
TI  - [Dose distribution in 60Co 2-field opposing irradiation therapy for cancer of the
      uterine cervix].

PMID- 1035027
TI  - Nephrotic syndrome with early renal amyloidosis in juvenile rheumatoid arthritis.

PMID- 1035028
TI  - Variations in the spontaneous activity of the uterine muscle in vitro and in situ
      and its response to oxytocin.
AB  - A study is made of the contractile and bioelectrical activities of the uterine
      muscle of guinea-pig in vitro and of rabbit in vitro and in situ, as well as
      their Oxytocin-induced changes upon different balance of the ovarial hormones. In
      rabbits in situ the uterine muscle contractions are longer and are recorded with
      a slower rhythm than in vitro. Both in situ and in vitro the sensitivity of the
      myometrium to Oxytocin is lower upon domination of progesteron and higher upon
      domination of oestrogen. In guinea pigs the myometrium is least sensitive to
      Oxytocin in the juvenile animals as compared with the sexually mature ones. The
      sensitivity of the guinea-pig myometrium to oxytocin in the various phases of the
      oestral cycle is weakest during dioestrus and strongest during oestrus.

PMID- 1035029
TI  - Pharmacological analysis of certain mechanisms of morphine addiction.
AB  - The effects of L-Dopa, Methysergid, Diphenhydramine hydrochloride and LSD on the
      development of morphine dependence and the abstience syndrome after its
      withdrawal, were tested in experiments on 200 male Wistar albino rats. L-Dopa had
      no efect on the development of physical morphine dependence, while Methysergid
      prevented its development. Applied in rats during the abstinence syndrome, LSD
      intensified their aggressivity with no influence on the analgesic effect of
      morphine. Diphenhydramine reduced the aggressiveness of the rats during the
      abstinence syndrome. Biochemical tests show that in morphine-tolerant rats there
      was an increase in the content of brain serotonin, less of dopamine and no
      changes in noradrenaline. The significance of the brain levels of serotonin,
      dopamine and noradrenaline for the development of physical morphine-dependence is
      discussed. It is pointed out that serotonin and dopamine play an important role
      both for the origin of the physical morphine dependence, and in the abstinence
      syndrome after its withdrawal.

PMID- 1035030
TI  - [Flavonoid compounds of the Convallaria majalis herb].

PMID- 1035031
TI  - Exocrine pancreatic function measured by secretin-pancreozymin test in chronic
      duodenal ulcer.

PMID- 1035032
TI  - The induction of cytochrome P-450 by hypoxia.

PMID- 1035033
TI  - Control mechanisms of oxygen and glucose utilization in tumours.

PMID- 1035034
TI  - Development and adaptation of heart mitochondrial respiratory chain function in
      fetus and in newborn.

PMID- 1035035
TI  - Experimental and theoretical analysis of oxygen transport in fetal brain.
AB  - Based on the results obtained in this study and the results of others it seems
      safe to conclude the following: 1) Fetal brain PO2 values are considerably lower
      than those found in adult brain. 2) Administration of 100% oxygen to the mother
      can (but not always) significantly raise the PO2 at a specific point in the fetal
      cortex. 3) The response of fetal brain PO2 to changes in maternal arterial PO2 is
      delayed by a finite quantity of time of the order of magnitude of 38 seconds. 4)
      The time required for the fetal brain PO2 to reach a minimum following a decrease
      in the PO2 of maternal arterial blood coincides closely with the time required
      for the maternal arterial PO2 to reach its minimum plus the pure transport delay
      time (38 seconds). 5) The fetus has available a control mechanism which acts to
      compensate for periods of reduced PO2 in the microenvironment of the fetal
      cortex.

PMID- 1035036
TI  - An electron microscopic study of the lens epithelium in a mouse strain with
      hereditary cataract.

PMID- 1035037
TI  - [Effects of long term local administration of steroid on the phospholipid
      metabolism of rabbit lens (author's transl)].

PMID- 1035038
TI  - [Environmental behavior on the lens opacification (author's transl)].

PMID- 1035039
TI  - [Aggregation and denaturation of lens proteins in the cataract formation
      (author's transl)].

PMID- 1035040
TI  - [Our iridocapular lens (Gifu lens I) and its implantation (author's transl)].

PMID- 1035041
TI  - [Histochemical studies on the human trabecular meshwork. Part II. Enzyme
      digestions upon the masked acidic glucosaminoglycans in the normal human
      trabecular meshwork (author's transl)].

PMID- 1035042
TI  - [Electron microscopic study on the trabecular tissues in glaucoma capsulare
      (author's transl)].

PMID- 1035043
TI  - [Electron microscopic studies on the aegle of the anterior chamber in glaucoma
      capsulare (author's transl)].

PMID- 1035044
TI  - [Critical pressure in glaucoma (author's transl)].

PMID- 1035045
TI  - [Moire topographic method for measuring the depth of papillary excavation
      (author's transl)].

PMID- 1035046
TI  - [Checkerboard pattern reversal VER in the assessment of glaucomatous field
      defects (author's transl)].

PMID- 1035047
TI  - [An electron histochemical study on the human cornea of the various developing
      stages (author's transl)].

PMID- 1035048
TI  - [Antiviral action of amphotericin B methyl ester (AME) against herpetic keratitis
      in rabbits (author's transl)].

PMID- 1035049
TI  - [Cell-mediated immune response in guinea pigs with experimental herpetic
      keratitis (author's transl)].

PMID- 1035050
TI  - [Control of experimental herpetic keratitis by immune spleen cells (author's
      transl)].

PMID- 1035051
TI  - [Keratoconus--experience with 550 cases (author's transl)].

PMID- 1035052
TI  - [Ultrastructure of the developing neuromuscular junctions in the rat extraocular
      muscles (author's transl)].

PMID- 1035053
TI  - [A new type of accommodation synoptophore (author's transl)].

PMID- 1035054
TI  - [Binocular infrared videopupillography (author's transl)].

PMID- 1035055
TI  - [Peripheral retinal vessels in the normal newborn (author's transl)].

PMID- 1035056
TI  - [A case of angiospastic neuroretinopathy --observation by scanning and
      transmission electron microscopy-- (author's transl)].

PMID- 1035057
TI  - [Studies on dynamic changes of crystalline lens due to accommodation. Report II.
      A study on changes of anterior surface of lens during accommodation (author's
      transl)].

PMID- 1035058
TI  - [Thrombotic troubles of uremic patients (author's transl)].

PMID- 1035059
TI  - [Histologic studies on the nodules protruding into the lumina at the sites of
      branching of the retinal arterioles in spontaneously hypertensive rats (SHR)
      (author's transl)].

PMID- 1035060
TI  - [Acute prostatitis followed by septicemia caused by anaerobic bacteria].

PMID- 1035061
TI  - Compositional data on some Persian bezoars.
AB  - Fourteen Bezoars from Persia, used in past times and even to-day as a medicine or
      as a health-preserving precious tone, are examined. Among the concretions ellagic
      acid prevails. Some are bile pigmented or calcite stones. Other bezoars are
      mineral substances or artifacts.

PMID- 1035062
TI  - [Electrical activity of human embryo heart cells under hypoxic conditions].

PMID- 1035063
TI  - [Role of electroanalgesia in the complex treatment of nephropathy and
      hypertension in pregnant women].

PMID- 1035064
TI  - The rapid onset of inhibition of antibody-forming cell proliferation upon an
      increase in density of cellular suspensions cultured in vitro.
AB  - It was shown previously that the development of primary immune response in vitro
      in the Mishell-Dutton system was strongly inhibited by increased cell densities
      (Gurvich et al., Immunology 1975. 28: 271). In the present work, the rate of
      onset of this inhibition was studied in C57BL/6 mouse spleen cell suspensions
      during the phase of exponential increase of antibody-forming cells (AFC) after 3
      days' cultivation in vitro with the antigen. It has been shown that the increase
      in AFC number is very soon inhibited following an increase in the cellular
      density, the inhibition already being evident within 2 or 4 h. Parallel reduction
      in incorporation of radioactive precursors in DNA and especially RNA is observed,
      whereas inhibition of protein synthesis was delayed.

PMID- 1035065
TI  - [Angioimmunoblastic lymphadenopathy].

PMID- 1035066
TI  - [Ultrasonic echography in the diagnosis of obstructive myocardopathy].

PMID- 1035067
TI  - [AHR 6134: a new tranquilizer with unexpected results].

PMID- 1035068
TI  - Retinal detachment secondary to branch vein occlusion: Part I.
AB  - Eight patients with retinal detachment secondary to branch vein occlusion were
      studied. Retinal detachment secondary to branch vein occlusion occurs when the
      vein occlusion is severe and there is marked capillary nonperfusion and leakage.
      The detachment is limited to the area of the occluded vein and does not extend
      beyond the equator. Usually the detachment is shallow; however, it can be bullous
      as demonstrated in 3 of our patients. Fluorescein angiography revealed the
      typical findings associated with branch vein occlusion, in addition to late
      pooling of the dye into the fluid in the subretinal space. In each of the 6 cases
      treated by laser photocoagulation, reattachment of the retina occurred. The
      disease is discussed from the standpoint of ocular findings, fluorescein
      angiography, diagnosis and differential diagnosis, course, treatment, and
      prognosis.

PMID- 1035069
TI  - Retinal detachment secondary to branch vein occlusion: Part II.

PMID- 1035070
TI  - [Stress urinary incontinence (functional and x-ray diagnosis)].

PMID- 1035071
TI  - [Presence of ergosterol and portensterol in mycelial cultures of Tricholoma
      portentosum and Rhodopaxillus nudus].

PMID- 1035072
TI  - [Amicrobic pustuloses and calcemia. Generalized pustular psoriasis, type
      Zumbusch, contemporary with hypocalcemia, in a patient with chronic kidney
      failure, under hemodialysis].

PMID- 1035073
TI  - The possibility of a flaw underlying Weinberg's differential rule.
AB  - There seems rather good evidence that there is a flaw underlying Weinberg's
      Differential Rule, and that among DZ twin pairs, there are perhaps eight same
      sexed pairs to every seven opposite-sexed pairs.

PMID- 1035074
TI  - Paternal age, stillbirths and mutation.
AB  - Previous suggestions that accumulation of mutations in the germ line of ageing
      fathers causes an increased stillbirth rate were based on analyses of data which
      were heterogeneous for social variables whose effects were confounded with
      possible paternal age effects. This study was confined to the analysis of
      stillbirth rates of groups of women selected to be homogeneous for education,
      previous pregnancy outcomes, age, race and marital status. It is concluded that
      stillbirth rates do not increase with father's age independently of maternal
      variables. Neither accumulation of mutations in the paternal germ line nor other
      biological change associated with father's age can be inferred to cause an
      increase in risk of stillbirth with increasing paternal age.

PMID- 1035075
TI  - The effect of halides on the equilibrium and reactivity of aspartate
      aminotransferase.

PMID- 1035076
TI  - Reaction of antibody to normal human hypoxanthine phosphoribosyltransferase with
      products of mutant genes.

PMID- 1035077
TI  - [The effects of oxygen deprivation on the synthesis of DNA in chick embryo
      fibroblasts in vitro].

PMID- 1035078
TI  - [Cytochemical and ultrastructural study of oocyte development in the crab
      Eriocheir sinensis. I. Natural ovogenesis].

PMID- 1035079
TI  - Variety of 2,4-D metabolic pathways in plants; its significance in developing
      analytical methods for herbicides residues.
AB  - 2,4-D in plants very rapidly undergoes various transformations and its
      predominant metabolic pathways and rates vary with different plant species. In
      bean and soybean plants major 2,4-D metabolites are 4-O-beta-D-glucosides of 4
      hydroxy-2,5-dichloro- and 4-hydroxy-2,3-dichloro-phenoxy-acetic acids; in
      addition, considerable amounts of N-(2,4-dichlorophenoxyacetyl)-L-aspartic and N
      (2,4-dichlorophenoxyacetyl)-L-glutamic acids are accumulating in them. Among 2,4
      D metabolites in cereals there prevailed 1-O-(2,4-dichlorophenoxyacetyl)-beta-D
      glucose while the glycoside of 2,4-dichlorophenol prevailed in strawberry plants.

PMID- 1035080
TI  - [The "mycoplasma pneumoniae" in pathological respiratory processes. Serological
      disease (author's transl)].
AB  - The AA. present the results obtained determining by the F.C. test the antibodies
      for respiraotry viruses and for Mycoplasma pneumoniae over 1112 patients, of
      which 742 affected with pathological respiratory processes, during the period
      1971-1975. 104 patient have shown a significant correlation between respiratory
      disease and antibody movement for M. pneumoniae. They have been classified
      according to their clinical-radiological properties as follows: 38 affected with
      pneumonia; 37 affected with pleuritis; 29 affected with tracheobronchitis.
      Particularly interesting is the range of occurrence of the disease: we have
      noticed a high incidence in the period 1971-1972, followed by an almost complete
      disappearance of pathological instances in the period 1973-first semester of
      1975, and signs of a new recrudescence in the second semester of 1975. These data
      have been confirmed also by investigations carried out among healthy people. It
      has also to be pointed out the possibility of family's epidemicity, and the AA.
      report two epidemic cases under personal observation.

PMID- 1035081
TI  - [Role of central catecholamines in the psychostimulant activity of pyrovalerone].
AB  - A comparative study of the effects of alpha methylparatyrosine (alpha MPT) and/or
      reserpine pretreatments on mice motorhyperactivity and rat stereotyped behaviour
      induced by pyrovalerone and amphetamine suggests a different mechanism for these
      two substances. Both behavioral effects were abolished by alpha MPT but not
      altered by reserpine in the case of amphetamine which presumably acts through a
      selective release of "newly synthesized" catecholamines from a "functional" pool.
      In contrast to this, pyrovalerone would increase spontaneous motor activity
      through a preferential release of norepinephrine from a "storage" pool since
      motorhyperactivity was not altered by alpha MPT especially during the first
      phase, whereas it was abolished by reserpine. Stereotyped behaviour induced by
      pyrovalerone, was still present after pretreatment with alpha MPT or reserpine;
      these data suggest an action through a release of both "newly synthesized" and
      "stored" dopamine. On the other hand, a direct action on dopamine receptors might
      be involved after high doses of pyrovalerone and amphetamine since stereotyped
      behaviour was found to be present after a combined pretreatment with alpha MPT +
      reserpine.

PMID- 1035082
TI  - [Future prospect of vascular surgery].

PMID- 1035083
TI  - [Clinical studies on results of repair of ventricular septal defect associated
      with severe pulmonary hypertension. Mortality and hemodynamic changes in various
      age groups].

PMID- 1035084
TI  - [Chemically defined diets from viewpoint of formation of gallstones (author's
      transl)].

PMID- 1035085
TI  - [A collective review of the 796 cases of gallstones operated on at 23 hospitals-
      the second report (author's transl)].

PMID- 1035086
TI  - [Gallstone ileus (author's transl)].

PMID- 1035087
TI  - [Case report: Primary Hodgkin's disease of the ileum with intussusception
      (author's transl)].

PMID- 1035088
TI  - A note on the kinetics of uptake of D-glucose by the food yeast, Candida utilis.
AB  - Unlike other yeasts so far investigated, the D-glucose carrier of Candida utilis
      (strain NCYC 737) appears to change affinity for D-glucose according to its
      exogenous concentration. When the concentration of D-glucose was less than 0.4
      mM, the apparent Km approximately 0.2 mM; at greater than 0.4 mM, the Km
      approximately 10 mM.

PMID- 1035089
TI  - [Relationship between the limbic system and gonadal function. Quantifiable
      morphokinesis of the medial amygdaloid nucleus with reference to the estrous
      cycle].
AB  - Karyovolumetric investigation showed that in rat the neurons of the limbic system
      which are associated with the Pars caudalis of the nucleus amygdaloideus medialis
      followed a morphokineses which was quantifiable in relation to the oestral cycle.
      The cell nuclei differed significantly in volume between cycle phases, which was
      interpreted as morphological correlation between variations in neuronal activity
      of metabolism. It was thought to be another point in support of the relationship
      between the amygdala and central-nervous structures of the cerebro-pituitary
      gonadal axis.

PMID- 1035090
TI  - Synthesis and biological properties of derivatives of 3-methyl-5-aminoisothiazolo
      4-carboxylic acid.
AB  - The reaction of 3-methyl-5-aminoisothiazolo-4-carboxylic acid with the chlorides
      of chloroacetaic acid and chloropropionic acid gave 3-methyl-5-chloroacetyl- and
      5-chloropropionylisothiazolo-4-carboxylic acids, which upon heating in anhydrous
      ethanol with aliphatic and aromatic amines gave the respective 5-aminoacetyl and
      amino-propionyl derivatives of these acids. Iodoacetyloaminoisothiazolo-4
      carboxylic acid in reaction with ammonia was converted in 3-methylo-5
      aminoacetylo-aminoisothiazolo-4-carboxylic acid, which upon heating in toluene
      with isocyanates and isothiocyanates gave the respective derivatives of urea and
      thiourea. Some of the synthesized compounds showed psychotropic and cytostatic
      activity.

PMID- 1035091
TI  - [Protein utilization of mixed feed rations in lactating pigs with reference to
      the essential amino acid content of the feed proteins. 2. Report. Utilization of
      the feed proteins in the use of soy bean extraction residue, waste liquor yeast,
      horse bean meal fish meal and maize gluten for a basic ration].
AB  - Nitrogen trials were performed on lactating pigs to investigate the utilization
      of protein from some feeding rations. The basal ration fed to the sows consisted
      of ground barley+oats+flaked potatoes or ground barley+sugar beet chips. The
      basal ration was supplemented with a protein source. The protein feeds used were
      extracted soya bean meal, horse bean meal, fish meal, maize gluten and waste
      liquor yeast. Data for the average biological value of the dietary proteins were
      as follows (in the given order of protein feeds): 61%, 59%, 54%, 58% and 37%. PPV
      data were: 44%, 43%, 39%, 44% and 28%. The proteins of nearly all rations were
      deficient in lysine when compared with the range of amino acids present in the
      proteins of sow milk.

PMID- 1035092
TI  - [The substitution of protein feed by lysine supplemented protein-rich wheat
      during the raising and laying periods of hens. 7. Report. Determination of the
      true digestibility of amino acids with and without lysine supplement in the
      feed].
AB  - In the present paper regression techniques were used for determing the true
      digestibility of amino acids from lysine-supplemented rations fed to laying hens
      as compared with unsupplemented rations of the same composition. 5 groups of 4
      hens each were investigated receiving graded amounts of food and nutrients. The
      daily amounts of pellets fed per bird in group 1 to 5 were 120 gms, 100 gms, 80
      gms, 60 gms and 40 gms. The quantity of lysine contained in 100 gms of the
      pellets was 664 mg in ration 1 and 554 mg in ration 2, the corresponding N values
      being 2.57 gm and 2.62 mg. The total amount of endogenic amino acids excreted per
      day was 128 mg per kg of body weight in birds receiving the lysine-supplemented
      ration and 132 mg per kg of body weight for the lysine-deficient ration. Data for
      the true digestibility of lysine and isoleucine were significantly higher in the
      case of the lysine-supplemented ration than with the lysine-deficient mixture.
      Lysine values were 86% and 75%, the corresponding lysine data in crude faecal
      proteins 4.8% and 7.1%. Generally speaking, the crude faecal protein of hens fed
      the lysine-deficient diet contained higher proportions of most of the essential
      and non-essential amino acids.

PMID- 1035093
TI  - [The replacement of skim milk in the diet of young pigs with an extremely short
      suckling period. 3. Report. Use of liquid substitute feed on the basis of skim
      milk, fish meal and wheat under production conditions].
AB  - A trial was performed in which 273 piglets received a liquid milk diet between
      the 12th and 30th day of age. This was compared with a liquid experimental diet,
      in which 60% of the milk was replaced by fish meal and wheat. Both diets were
      given as sole feed under practical feeding conditions. The experimental diet
      produced a weight increase of 81,9% relative to that of the milk diet; milk
      consumption was 53.7% the required amount of dry matter 117.4%, milk consumption
      per kg of weight gain 61.5% and expenditure on feed per kg of weight gain 78%.
      The general growth development of the piglets was quite good irrespective of the
      different rates of weight increase. The weight gains after 30 days were 6.6 kg+/
      1.5 kg for the experimental diet and 7.0 kg+/-1.2 kg for the milk diet. Losses
      among the piglets amounted to 0.7% and 2.9%. On the basis of the results of the
      present trial and of previous experiments the authors believe that under
      practical conditions of feeding 50% of the milk contained in a liquid milk diet
      fed to piglets that are 12 to 30 days of age could be replaced by wheat and fish
      meal.

PMID- 1035094
TI  - Growth, purification and characterization of Semliki Forest virus in Ehrlich
      ascites tumor cell suspensions.
AB  - The growth of Semliki Forest Virus (SFV) in suspension cultures of Ehrlich
      Ascites (EA) cells and its purification is described. Large volumes of virus
      material were concentrated by filtration with DIAFLO XM-300 membrane and
      precipitation with ammonium sulfate. A combination of protamine sulfate
      treatment, centrifugation of the virus onto a 50 per cent sucrose cushion, and
      sedimentation through a 5--30 per cent sucrose density gradient was employed. The
      purified virus particles were homogeneous as revealed by electron microscopy, by
      moving boundary electrophoresis, and by polyacrylamide gel electrophoresis. Virus
      suspensions containing 1 mg/ml of protein had a hemagglutinin titer of 1:12,000
      when measured with 0.25 per cent goose red blood cells.

PMID- 1035095
TI  - UV irradiation of interferon-treated chick embryo cells enhances Sindbis virus
      growth.

PMID- 1035097
TI  - Lymnaea columella in aquariums.

PMID- 1035096
TI  - The role of the Tasmanian devil in the epizootiology of ovine cysticercosis and
      echinococcosis.
AB  - Tasmanian devils were fed infective cystic material of Taenia ovis, T. hydatigena
      and Echinococcus granulosus and later killed and examined for adult tapeworms. No
      infections with T. ovis were found after feeding 23 cysts to 8 devils. T.
      hydatigena were recovered from 5 to 41 devils and 10 worms established after
      feeding 417 cysticerci. No E. granulosus were recovered from any of 3 devils.
      Specimens of T. hydatigena appeared to develop as well in devils as in dogs. From
      these and previous results devils could be successful hosts to T. hydatigena and
      T. ovis. A survey of 320 devils failed to detect any natural infections with any
      of these 3 species.

PMID- 1035098
TI  - Electroconvulsive shock- or puromycin-induced retention deficits in goldfish
      given two active-avoidance sessions.

PMID- 1035099
TI  - Modulation of passive-avoidance behavior of rats by intracerebroventricular
      administration of antivasopressin serum.

PMID- 1035100
TI  - Exposure to the odor of food determines the eating preferences of rat pups.

PMID- 1035101
TI  - Prenatal influences on the responsivity of neonate rats.

PMID- 1035102
TI  - Retrieval facilitation in normal and amnesic rats with kinesthetic feedback.

PMID- 1035103
TI  - Variable temporal gradients of retrograde amnesia: contingency on tasks and
      species.

PMID- 1035104
TI  - Comparisons of sexual receptivity and proceptivity in female hamsters.

PMID- 1035105
TI  - Progesterone and 5alpha-reduced metabolites: facilitation of lordosis behavior
      and brain uptake in female hamsters.

PMID- 1035106
TI  - Pattern of food intake and body weight gain in aged, noncycling female rats.

PMID- 1035107
TI  - Studies on the behaviour of cyprinodont fish. III. The temporal patterning of
      aggression in Aphyosemion striatum (Boulenger).

PMID- 1035108
TI  - Effects of male aggressiveness on behavioural transitions in the reproductive
      cycle of the Barbary dove.

PMID- 1035109
TI  - Purification and some properties of a medium-chain acyl-thioester hydrolase from
      lactating-rabbit mammary gland which terminates chain elongation in fatty acid
      synthesis.
AB  - 1. An acyl-thioester hydrolase was isolated from the cytosol of lactating-rabbit
      mammary gland. The purified enzyme terminates fatty acid synthesis at medium
      chain (C8:0-C12:0) acids when it is incubated with fatty acid synthetase and rate
      limiting concentrations of malonyl-CoA. These acids are characteristic products
      of the lactating gland. 2. The mol.wt. of the enzyme is 29000+/-500 (mean+/-S.D.
      of three independent preparations), as estimated by polyacrylamide-gel
      electrophoresis in the presence of sodium dodecyl sulphate. 3. The enzyme also
      hydrolyses acyl-CoA esters of chain lengths C10:0-C16:0 when these are used as
      model substrates. The greatest activity was towards dodecanoyl-CoA, and the three
      preparations had specific activities of 305, 1130 and 2010 nmol of dodecanoyl-CoA
      hydrolysed/min per mg of protein when 56muM substrate was used. 4. The way in
      which this enzyme controls the synthesis of medium-chain fatty acids by fatty
      acid synthetase is briefly discussed.

PMID- 1035110
TI  - [Contribution to the knowledge of ovarian pregnancy (author's transl)].

PMID- 1035111
TI  - Administration of peripheral-blood rat-lymphocytes stimulated "in vitro" with
      human lymphokines and spleen colonies in the total body irradiated rat.
AB  - It was previously reported that PHA-incubation of a pool of peripheral-blood
      lymphocytes before their i.v. injection into rats submitted to total body
      irradiation, stimulates spleen colony formation and growth. On the same model,
      the present study has investigated the effect of lymphocyte preincubation with
      supernates obtained in short term cultures from human lymphocytes prestimulated
      with PHA (lymphokines). The "in vitro" culture of rat lymphocytes in a medium
      supplemented with human lymphokines showed either a marked increase of lymphocyte
      survival rate, or significant stimulation of lymphocyte blastogenesis, but at an
      extent much lower than that caused by PHA, also because in this particular
      experiment the culture medium was supplemented with too little amount of
      lymphokines. These data support the interpretation that human lymphokines may act
      across the species barriers. Peripheral-blood rat lymphocytes prestimulated with
      human lymphokines, and then injected i.v. into rats previously submitted to total
      body irradiation, caused significant increase in the spleen weight, as well as
      formation of spleen colonies quite larger and with higher erythroid
      differentiation - though less numerous than in the controls (i.e., in the rats
      injected just with untreated lymphocytes). This behaviour may be due to the
      tendency to merge together of two or more colonies in a single giant colony, and
      supports the interpretation that immune-competent lymphocytes activated either
      with PHA or with lymphokines may stimulate spleen colony growth and erythroid
      differentiation, though at different extents.

PMID- 1035112
TI  - Effect of halothane and diethyl ether on the circulatory response to carbon
      dioxide in the isolated perfused cat lung.
AB  - Constant flow perfusion of the pulmonary circulation was established in isolated
      cat lungs. These were ventilated with 5% carbon dioxide in oxygen in order to
      maintain a near-normal carbon dioxide tension and acid-base status in the
      perfusing blood. The alteration of pulmonary vascular resistance in response to a
      change in inspired carbon dioxide concentration from 5% to 10% was investigated
      before, during and after the administration of 1% halothane (in 16 perfusions) or
      5% diethyl ether (in 8 perfusions). An increase of inspired carbon dioxide
      concentration caused a significant increase in pulmonary vascular resistance, but
      the magnitude of the increase was diminished during the administration of both
      anaesthetic agents. The response increased again after the anaesthetics were
      withdrawn. The administration of halothane during ventilation with 5% carbon
      dioxide caused a significant reduction of pulmonary vascular resistance whilst
      diethyl ether resulted in a significant increase in this measurement. It is
      suggested that inhalation anaesthetic agents may increase ventilation/perfusion
      mismatching by altering the normal vasoconstrictor response to increased alveolar
      PCO2;

PMID- 1035113
TI  - The effect of narcotic and narcotic-antagonist drugs in the newborn rabbit.
AB  - The newborn rabbit responds to acute anoxia, as a result of breathing nitrogen,
      with successive periods of dyspnoea, primary apnoea, gasping and terminal apnoea.
      Pethidine caused an increase in the period of primary apnoea and a decrease in
      the duration and rate of gasping. When nalorphine was combined with pethidine the
      period of primary apnoea was still increased although the duration and number of
      gasps were restored to control values. Naloxone, in contrast, acted as a mild
      respiratory stimulant, shown as a longer phase of dyspnoea. Also it completely
      abolished the respiratory depression produced by pethidine. Naloxone may be
      preferable to nalorphine as a drug to reverse the effects of pethidine
      immediately after birth.

PMID- 1035114
TI  - Kinetics of inhibition of acetylcholinesterase by spin labeled acetylcholine
      analogs.
AB  - A series of spin labeled acetycholine analogs, in which the number of methylene
      groups between the quaternary nitrogen and the alcohol oxygen ranged between 1-5,
      have been examined as inhibitors of electric eel acetylcholinesterase. Evidence
      is presented suggesting that inhibition of acetylocholinesterase by the spin
      labeled ACH analogs is due to the high affinity of these compounds for the
      enzyme, inhibition is competitive and reversible. It has been shown that complex
      formation is of major importance in the reaction between spin labeled ACH analogs
      and acetylcholinesterase. The acetylation step has been shown to occur by
      demonstrating that the leaving group is released as the reaction proceeds.
      Complex formation has been demonstrated by means of kinetic criteria. Kinetic
      parameter have been measured for the five compounds, and correlations with
      alkaline hydrolysis are disussed.

PMID- 1035115
TI  - [Atherosclerosis in rabbits induced by prolonged electrical stimulation of the
      hypothalamus].
AB  - The influence of prolonged electrical stimulation of rabbit hypothalamus on blood
      lipids and the development of atherosclerosis were studied. The negative
      emotional state observed during the electrical stimulation was accompanied by
      blood hyperlipemia and atherosclerosis development in 1/3 noncastrated and 2/3
      castrated animals.

PMID- 1035116
TI  - [Effect of aflatoxin B1 in vitro and in vivo].
AB  - The direct and transplacental action of aflatoxin B1 was studied on organic
      cultures of the embryonic pulmonary tissue of mice of the A line, BD-IX rats and
      golden hamsters (Cricetus auratus W.). Its toxic action on the cultures and the
      absence of any blastomogenic effect was demonstrated. In experiments on mice the
      transplacental penetration of aflatoxin B1 led to an increase in the incidence of
      the breast tumours in the progeny.

PMID- 1035117
TI  - [Duration of the mitotic cycle of Chinese hamster cells cultured at 30--39
      degrees].
AB  - The duration of the mitotic cycle (T) at temperatures of 30, 33, 36 and 39
      degrees C was studied in subline 237 of Chinese hamster cells with the aid of the
      radioautographic method. T was the least at 39 degrees C and increased with
      reduction of the cultivation temperature. At the temperature range of 33--39
      degrees C prolongation of T and its periods was "proportional" to the temperature
      under study. The characteristic curve gradient of T dependence on the temperature
      showed a sharp change in the direction of greater figures with the temperature
      reduction from 33 to 30 degrees C. Analysis of the results of other studies on T
      duration of the human amniotic cells demonstrated that such sharp elevation of
      the duration of the mitotic cycle occurred with the change from 39 to 40--41
      degrees C. The G1 period was the most and G2--THE LEAST Sensitive to changes of
      the cultivation temperature.

PMID- 1035118
TI  - [Comparative characteristics of compensatory renal hypertrophy following
      unilateral nephrectomy in mature and old rats].
AB  - One of the kidneys was removed in rats from 35 to 900 g in weight; they were then
      sacrificed 2, 14, 30 and 60 days after the operation. The degree of compensatory
      hypertrophy of the remaining kidney varied greatly in rats of different age,
      without decreasing in old age, however. Sixty days after the operation the weight
      of the hypertrophic kidney in old rats was equal to 55--93% of the weight of both
      kidneys in control. Hypertrophy of the kidney at any age was accompanied by an
      increased proliferation of the tubular cells, particularly in their proximal
      portion. An increase in the size of renal bodies during kidney hypertrophy was
      characteristic of rats of any age. However, with the advance of age this process
      developed more rapidly and was stronger. At any periods of investigation the
      hypertrophic kidney in rats of any age contained a greater number (1 1/2--2 times
      more) of "open" renal bodies in comparison with the kidney of intact rats.

PMID- 1035119
TI  - [Irreversible character of the antimitotic effect of actinomycin D on the egg of
      Artemia, in the early stages of cleavage].
AB  - Inhibition of cleavage by actinomycine D is irreversible. Discussion of the
      results gives new arguments in favour of a protein synthesis during G2. Necessary
      for the initiation of the following cell division.

PMID- 1035120
TI  - [Effects of amniotic fluid on the development of neoplastic tissue in organotypic
      culture].
AB  - In previous researches, it has been observed that the human amniotic fluid
      presents in vitro an antineoplasic action. 75% of the examined amniotic fluids
      contain an anti HCG principle. In order to evaluate if the effect of amniotic
      fluid is due to this principle, cultures of tumoral tissue have been performed,
      with the Wolff and Wolff's method, using media containing either positive
      amniotic fluid or negative amniotic fluid. Results obtained with positive
      amniotic fluid have confirmed the previous observations. A complete degeneration
      of both tumoral tissue and mesonephros was observed when the culture medium was
      enriched with negative amniotic fluid.

PMID- 1035121
TI  - Division of the external urethral sphincter in the neuropathic bladder: a twenty
      years' review.
AB  - It is now twenty years since the authors first performed division of the external
      sphincter region in the treatment of the neuropathic bladder. Although a ten year
      report was published in 1967, it was decided to review all the patients at the
      end of the twenty year period. The rationale of the operation in the upper motor
      neurone lesion has been confirmed by modern investigative techniques, while it
      appears from recent work that the success of the procedure in the lower motor
      neurone case is due to division of plain muscle which is subjected to excessive
      sympathetic stimulation. It is the authors' firm conviction that long term
      catheterization, whether permanent or intermittent is a confession of failure and
      can be avoided in the vast majority of patients. The operation has proved of
      permanent benefit especially with the regard to the elimination of residual
      urine. Further, hydronephrosis, and renal infection and failure, are also
      benefited in many cases. These factors are of great importance in a condition in
      which late morbidity and mortality has been usually due to renal causes.

PMID- 1035122
TI  - Anterior detrusor tube repair for urinary incontinence in children.
AB  - The technique, complications and results of an anterior detrusor tube repair for
      urinary incontinence in children is described. It appears that this procedure is
      appropriate only for selected cases of urinary incontinence but that it is an
      operation which should be within the paediatric urologist's repertoire. It is
      simple to perform, but care should be taken, by omental packing, to prevent a
      sharp posterior lip to the newly formed bladder neck.

PMID- 1035123
TI  - [Urinary excretion of estrogen in premature infants in relation to maternal
      estrogen].

PMID- 1035124
TI  - [Determination of thrombocyte adhesion to glass using a modification of a method
      by Mason and Gilkey].

PMID- 1035125
TI  - Selective ploidy of chromosomes in ascites tumor cells.

PMID- 1035126
TI  - Amino acids content in the proteins of fresh- and salt-water crustaceans.

PMID- 1035127
TI  - Natural occurrence of an inhibitor of mammalian cell growth in human and mouse
      cells of normal and tumor origin.
AB  - N6-(delta2-isopentenyl)adenosine was found both as a component of tRNA and as the
      cytoplasmic mononucleotide in human leukemic lymphoblasts and myeloblasts from
      peripheral blood and bone marrow samples. This hypermodified nucleotide was also
      found in the tRNA and as a mononucleotide in human (MRC-5 and KB) and mouse (A9,
      FLV, LM, and RAG) cell lines. The relative amounts of this hypermodified
      nucleotide in the tRNA of the cell lines and the human leukemias were similar
      (the mean value being 0.06 +/- 0.03 mole % of the total tRNA nucleotide content);
      whereas the amounts occurring as the free cytoplasmic mononucleotide were more
      varied but still comparable (the mean value being 0.53 +/- .09 mole % of all
      cytoplasmic nucleotides) for all cells investigated with the notable exception of
      all normal, diploid cell lines under study (0.04 mole%). A possible relationship
      of the free cytoplasmic mononucleotide with the nucleotide in the tRNA for
      control of mammalian cell protein synthesis in vivo was investigated by addition
      of N6-(delta2-isopentenyl)adenosine to the culture medium. The exogenously added
      nucleoside caused inhibition of cell growth within 3 h and cell death within 36 h
      at concentrations as low as 0.4 muM. No comparable effects were seen when
      adenosine, adenine, or N6-(delta2-isopentenyl)-adenine were added to the
      cultures. The simultaneous presence of adenosine in cultures containing N6
      (delta2-isopentenyl)adenosine did not alter the detrimental effects of the
      hypermodified nucleoside on cell growth even when the concentration of adenosine
      was 50-fold that of N6-(delta2-isopentenyl)adenosine. Addition of N6-(delta2
      isopentenyl)adenosine to cell cultures caused within the first 6 h a significant
      reduction in the rates of RNA and protein synthesis; whereas DNA synthesis
      continued at a rate comparable to control and adenosine-treated cells for 18 h
      before decreasing.

PMID- 1035128
TI  - Hydrocortisone inhibits the spontaneous detachment of viable mammary tumor cells
      from monolayer cultures.
AB  - Primary mammary adenocarcinomas of C3H mice were dissociated to single cells.
      These cells were seeded at a density of 5 x 10(5)/cm2 substrate area and were
      grown as monolayers for 36 days in high-serum medium supplemented with insulin.
      Cultures became confluent within a few days and confluence was maintained
      throughout the culture period. Viable cells (representing amitotic cell
      population) were released spontaneously from the confluent monolayer and could be
      harvested from the culture fluid. The rate of cell release declined after about
      30 days, apparently due to mitotic pool depletion. Release of cells from the
      monolayer was strongly depressed in medium containing hydrocortisone. The cell
      release event and its alteration by hydrocortisone can be interpreted as
      reflecting the propensity towards shedding of cells from these tumors in vivo and
      the alteration of metastatic incidence by adrenal steroids.

PMID- 1035129
TI  - Presence of cellular rentinol and retinoic acid binding proteins in experimental
      rumors.
AB  - Cellular retinol and retinoic acid binding proteins were detected in mouse skin
      papillomas, human adenocarcinoma HAD-1, Dunning Leukemia, Walker 256
      carcinosarcoma and mammary adenocarcinoma MAC-1. A chondrosarcoma and Sarcoma 180
      apparently contain only the cellular retinoic acid binding protein. Neither
      protein could be detected in Ehrlich carcinoma and L1210 leukemia. The presence
      of these proteins might be necessary for sensitivity to retinoid therapy.

PMID- 1035130
TI  - Excision of epithelial tumors: CO2 laser versus conventional methods.
AB  - In a comparative experimental study, excisions of a transplanted Lewis lung
      carcinoma in BDF1 mice were performed by means of the CO2 laser and conventional
      methods, namely common scalpel and diathermy. The results showed a significant
      reduction in tumor recurrence and animal mortality rates (27.5% vs. 75% and 45%)
      after tumor excision with the laser in the early stage (5th day) of tumor
      development. This finding, in addition to the surgical properties of the CO2
      laser, suggests that early excision using this modality is a rational treatment
      of this type of tumor.

PMID- 1035131
TI  - Common metabolites of N-nitroso-2,6-dimethylomorpholine and N-nitroso-bis(2
      oxopropyl)amine in the Syrian hamster.
AB  - N-Nitroso-2,6-demethylmorpholine (NDMM) administered intraperitoneally to Syrian
      hamsters was metabolized  to N-nitroso-bis(2-hydroxypropy)(2
      oxopropyl)amine(HPOP) and N-nitroso-bis(2-hydroxpropyl)amine (BHP) which were
      identified in blood and urine. The potent pancreatic carcinogen N-nitroso-bis(2
      oxoproply)amine was previously shown to form the same metabolites. Preliminary
      results indicate that NDMM also induces pancreatic and other tumors in Syrian
      hamsters, similar to those found following BHP treatment.

PMID- 1035132
TI  - Phase I alternate-day dose study of chromomycin A3.
AB  - Chromomycin A3 was given to 43 patients with metastatic cancer in order to
      determine the tolerable dose when the drug was administered on an every-other-day
      dose schedule for a total of five iv push injections, with the course of therapy
      being repeated every 4 weeks. At least three patients were entered at each dose
      level, graduated in 0.1-mg/m2 increments between 0.7 and 1.6 mg/m2. The most
      common (19 patients) side effect was nausea and/or vomiting, but this was usually
      mild, lasted for a few hours, and diminished in severity with repeated
      injections. Skin necrosis due to drug extravasation was a problem early in the
      study, but was eliminated by injecting the drug through iv tubing. Transient
      elevations in SGOT and alkaline phosphatase levels were observed, but proved not
      to be of serious consequence. Renal toxicity proved to be the limiting factor in
      therapy. However, a dose level of 1.3 mg/m2 was found to be a tolerable level of
      drug administration in previously untreated patients. Objective tumor responses
      were noted in four patients (Hodgkin's disease, embryonal rhabdomyosarcoma,
      adenocarcinoma of the lung, and malignant melanoma).

PMID- 1035133
TI  - Studies with 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl)-,dihydrochloride.
      I. Cell kinetic and biologic effects in cultured L1210, human epidermoid No. 2,
      and adenocarcinoma 755 cells.
AB  - Experimental results obtained with cultured L1210, human epidermoid No. 2, and
      Adenocarcinoma 755 cells are consistent in showing that inhibition of
      proliferation of the cells by 2,5-piperazinedione, 3,6-bis(5-chloro-2-piperidyl)
      ,dihydrochloride is accompanied by cell enlargement. Although cells initially in
      the G2 phase when exposure to the agent is begun can probably proceed through
      mitosis and divide, cells that are initially in G1 and S phases accumulate in the
      G2 phase. Progression of cells to G2 phase during the period of exposure to the
      agent is not a requisite for cell-killing, because cells exposed for periods
      insufficient to permit their accumulation in G2 are killed.

PMID- 1035134
TI  - Structural studies on the extracellular polysaccharide of the red alga,
      Porhyridium.
AB  - Partial acid hydrolyzates of the extracellular polysaccharide from Porphyridium
      cruentum yield three disaccharides and two uronic acids. These constitute all of
      the uronic acid in the polymer. The novel disaccharides are 3-O(alpha-D
      glucopyranosyluronic acid)-L-galactose, 3-O-(2-O-methyl-alpha-D
      glucopyranosyluronic acid)-D-galactose, and 3-O-(2-O-methly-alpha-D
      glucopyranosyluronic acid)-D-glucose. The polyanion of high molecular weight
      contains D- and L-galactose, xylose, D-glucose, D-glucuronic acid and 2-O-methyl
      D-glucuronic acid, and sulfate in molar ratio (relative to D-glucose) of
      2.12:2.42:1.00:1.22:2.61. Preliminary periodate-oxidation studies suggest that
      the hexose and uronic acids are joined to other residues by (1 leads to 3)
      glycosidic linkages. About one-half of the xylose residues are (1 leads to 3)
      linked.

PMID- 1035135
TI  - [Hypertrophic cardiomyopathy with infundibular isolated dynamic stenosis of the
      right ventricle].

PMID- 1035136
TI  - Microinjection studies of duck globin messenger RNA translation in human and
      avian cells.
AB  - Microinjection techniques were used for the study of the translation of
      heterospecific messenger RNAs in living cells. Duck globin messenger RNAs, in the
      form of polysomes, messenger ribonucleoprotein particles, or free mRNAs, were
      injected into cells of human origin (HeLa), and the subsequent appearance and
      accumulation of avian globin were measured by specific immunofluorescence
      techniques. Globin accumulated within a high proportion of HeLa cells for at
      least 25 hr following injection, indicating the intracellular stability of the
      heterospecific globin messenger RNA and the fact that mRNA initially associated
      with more complex structures could be translated in the HeLa cytoplasm. In
      similar experiments, duck reticulocyte polysomes were shown to be translated in
      duck embryo cells but not in embryonic chick liver cells. The latter, however,
      could be shown to withstand the microinjection procedure as judged by their
      capacity to respond normally to inducers and inhibitors of the synthesis of alpha
      aminolevulinic acid synthetase. HeLa cells injected with duck hemoglobin divide
      at normal or nearly normal rates following the injection, but their globin
      content diminishes, in contrast with the increasing globin content of cells
      receiving duck reticulocyte polysomes, mRNP particles, or free mRNA.

PMID- 1035137
TI  - The 3' terminal sequences of human alpha and beta globin messenger RNAs:
      comparison with rabbit globin messenger RNA.
AB  - Sequences of 43 and 70 nucleotides adjacent to the 3' terminal poly(A) of human
      alpha and beta globin mRNAs have been established. Sequence analysis of
      complementary DNA from both normal and thalassemic globin mRNA preparations was
      carried out using endonuclease IV digestion and limited synthesis procedures. The
      two RNA sequences are 83% homologous to rabbit globin mRNA (Proudfoot, 1976), and
      a part of the alpha globin mRNA sequence codes for the carboxy terminus of human
      alpha globin Constant Spring (Clegg, Weatherall, and Milner, 1971). This latter
      result predicts that the 3' noncoding region of human alpha globin mRNA is
      exactly 112 nucleotides, while the 5' noncoding region is probably about 50
      nucleotides.

PMID- 1035138
TI  - Chromatin organization in nuclei of sea urchin embryos. Comparison with the
      chromatin organization of the sperm.
AB  - The chromatin in sea urchin embryo nuclei and that in sperm heads are both
      organized in nucleosomes but show marked differences when analyzed by
      endonuclease digestion. Sperm chromatin DNA appears to be totally organized in
      nucleosomes that are highly resistant to nuclease hydrolysis. The kinetics of
      formation of acid-soluble oligonucleotides is slow and concerns only about 50% of
      the total DNA. In contrast, the DNA of embryo chromatin does not appear to be
      totally organized in nucleosomes since 5 to 10% is rapidly and preferentially
      hydrolysed into acid-soluble oligonucleotides without any appreciable
      fragmentation of the remaining parts. Futher digestion causes the formation of
      the usual pattern of DNA bands, as detected by gel electrophoresis. The length of
      the DNA segment associated with the embryo nucleosomes appears to be shorter than
      that of the DNA segment associated with the sperm nucleosomes. The kinetics of
      formation of acid-soluble oligonucleotides upon digestion of embryo chromatin is
      much faster than that of sperm chromatin and concerns almost all the chromatin
      DNA.

PMID- 1035139
TI  - [Clinical diagnosis of hyperphenylalaninemia in the newborn infant and infant
      stages].

PMID- 1035140
TI  - Studies on peptides. LXII. Synthesis of the protected octadecapeptide
      corresponding to positions 26 through 43 of porcine gastric inhibitory
      polypeptide (GIP).

PMID- 1035141
TI  - Studies on peptides. LXIII Synthesis of the octacosapeptide corresponding to
      positions 1 through 28 of porcine gastric inhibiting polypeptide (GIP).

PMID- 1035142
TI  - Studies on peptides. LXIV. Synthesis of the tritetracontapeptide corresponding to
      the entire amino acid sequence of porcine gastric inhibitory polypeptide (GIP).

PMID- 1035143
TI  - Studies on peptides LXV. Conventional synthesis of a new hypothalamic peptide,
      bovine neurotensin.

PMID- 1035144
TI  - Studies on peptides. LXVI. Synthesis of the protected heptadecepeptide amide
      related to the C-terminal portion of porcine cholecystokinin-pancreozymin (CCK
      PZ).

PMID- 1035145
TI  - Studies on peptides. LXVII. Synthesis of the hexadecapeptide corresponding to
      position 1 through 16 of porcine cholecystokinin-pancreozymin (CCK-PZ).

PMID- 1035146
TI  - Studies on peptides. LXVIII. Synthesis of the tritriacontapeptide amide
      corresponding to the entire amino acid sequence of the desulfated form of porcine
      cholecystokinin-pancreozymin (CCK-PZ).

PMID- 1035147
TI  - [Hemodynamic study in animals and man on a new sympathomimetic amine:
      dimethophrine].

PMID- 1035148
TI  - Vitamin A acid: clinical investigations with 405 patients.
AB  - Vitamin A acid (retinoic acid) is less toxic than vitamin A and seems to be an
      important advance in dermatology. Its therapeutic effect was investigated in
      clinical studies involving 405 patients. Biochemical investigations have shown
      that the administration of vitamin A acid is associated with elevation of serum
      levels of retinol and carotene and after high dosage symptoms develop identical
      with hypervitaminosis A. Several possibilities regarding the mode of action of
      vitamin A acid are discussed.

PMID- 1035149
TI  - Perioral dermatitis: etiology and treatment.
AB  - Ninety-five patients with perioral dermatitis were studied from an
      epidemiological aspect. Consistent clearing of the eruption was obtained with
      oral tetracycline in combination with a topical sodium sulfacetamide-sulfur-hydro
      cortisone lotion. Comparison of the study group of patients to a group of 50
      control patients revealed highly significant quantitative differences in the
      cosmetic preparations used by the two groups. This latter finding would suggest
      that lubricating and moisturizing products play some part in the etiology of
      perioral dermatitis.

PMID- 1035150
TI  - Malignant hemangioendothelioma (angiosarcoma).

PMID- 1035151
TI  - Allergic rhinitis and the technique of immunotherapy.

PMID- 1035152
TI  - Adverse drug reactions.

PMID- 1035153
TI  - Prognostic significance of ploidy level in human tumours. II extra-uterine
      cancers and summary of data on 1171 tumours.
AB  - The 5-year survival rate of 78 patients with carcinoma of the ovary showed that
      the prognosis was significantly better when the tumour modal DNA value was in the
      diploid region than when it was near-triploid or above. Similar data on 140
      patients with carcinoma of the breast and 52 with carcinoma of the bladder also
      suggested a better prognosis for the near-diploid tumours. Among 105 carcinomas
      of the large bowel, however, there were more survivors in the high-ploidy than in
      the near-diploid group, although the difference was not statistically
      significant. The varying relationship between ploidy and prognosis, depending on
      the site or histological type of the tumour, is briefly discussed on the basis of
      the 1171 cases included in the present and a previous paper.

PMID- 1035154
TI  - Sustained administration of cyclazocine for antagonism of morphine.
AB  - The plasma levels, distribution and excretion of tritium were determined after
      administration of a single or sustained dose of 3H-cyclazocine to naive and
      morphine-addicted rats. The plasma levels reached and maintainat animals tolerant
      to morphine were cross-tolerant to cyclazocine. Although only half the
      administered radioactivity was excreted after either a single dose or a
      continuous administration, no appreciable concentration was found in any of the
      organs studied. The behavior of a single or sustained dose of cyclazocine was
      also determined in rabbits to evaluate the effect of the implant site on the
      drugs release rate and tissue biocompatibility. The release-rate of 3H
      cyclazocine from a glyceride matrix implanted subcutaneously or intramuscularly
      could be controlled by modification of the matrix itself or by manipulation of
      the drug concentration within the matrix. Durations of action between a few days
      and a month were obtained by these means from devices that were both
      biodegradable and tissue compatible. The results indicate that the procedures
      used here may provide a practical means for administering narcotic antagonists to
      addicts.

PMID- 1035155
TI  - The role of physical dependence in animal models of human alcoholism.
AB  - This paper critically examines the concept that physical dependence is a
      necessary attribute for animal models of human alcoholism. On the basis of a
      review of the literature, it is argued that, since the production of physical
      dependence requires the presence of continuous high blood-alcohol levels, and
      since the production of preference for alcohol requires intermittent presentation
      of alcohol, the two cannot, in principle, be established in the same organism at
      the same time. It is further argued that physical dependence does not play a role
      in the development of high alcohol intake in animals. The implications of these
      observations for human alcoholism are discussed.

PMID- 1035156
TI  - Liberty caps: recreational hallucinogenic mushrooms.

PMID- 1035157
TI  - [Problems of yeast-colonization in the gastrointestinal tract].

PMID- 1035158
TI  - [Kinetics of proliferation of a mouse tumor cell line originating in the fetal
      large intestine].
AB  - The authors examine the kinetics of cellular proliferation of the cellular line
      STS, originating from adenocarcinoma, obtained after "spontaneous" malignization
      of a fragment from fetal colon. The cells of STS grow as a single layer and reach
      exponential phase on the 48th hour, but stationary phase-on the 96th hour of the
      culture. Time for doubling the number of the cells TD at the exponential phase of
      growth is 12 hours. The mitotic index varies from 7% at the exponential phase to
      1,3% at the stationary. Time of cellular cycle and its phases, estimated by the
      curves of the marked mitosis, shows the following values: TGi=5.3 hours, Ts=6
      hours, TG2=0.5 hour, TM=1,2 hour, and TC=13 hours. The authors discuss the
      differences in the data of TC and TD.

PMID- 1035159
TI  - Isolated perfused rabbit lung: a critical appraisal.
AB  - The isolated perfused lung (IPL), when compared to available in vitro and in vivo
      pulmonary systems, is a preparation that fulfills a majority of the ideal
      criteria for studying metabolism, binding and/or physiological response to
      xenobiotics. The IPL is an exceptionally useful method when there is a need for
      concurrent administration of multiple agents in different physical forms. Various
      details such as physiological and biochemical parameters and the construction of
      a small animal tracheal valve system are discussed.

PMID- 1035160
TI  - Survival of octogenarians: six years after initial chromosome examination.
AB  - The frequencies of hypodiploidy, hyperdiploidy, monosomy C, monosomy G, and
      breaks were lower in the 19 female octogenarians who survived chromosome
      examination by six years than in the 19 who died, although none of the
      differences were statistically significant. In men, if anything, the trend was in
      the opposite direction with the nine survivors having higher frequencies than the
      14 decedents. Again the differences were small and none were statistically
      significant. In neither sex, was there a relationship between length of survival
      and any of the parameters examined. Repeat chromosome examinations (two each,
      average interval 2.4 years) were available for seven women (one survivor and six
      decedents). There were no statistically significant differences between the two
      chromosome examinations except for an increase in monosomy C. Seven individuals,
      however, including but a single survivor, form too small a group to permit
      definitive conclusions about the lack of a relationship between chromosomal
      changes and survival.

PMID- 1035161
TI  - A behavioral-chromosome relationship in the elderly: a critical review of a
      biobehavioral hypothesis.
AB  - The evidence for the hypothesis that an increased frequency of hypodiploid cells
      is related to mental status in older persons, as well as the underlying
      assumptions crucial to the hypothesis, are reviewed. Results of chromosome
      examinations reported by several independent laboratories favor an increasing
      proportion of hypodiploid cells in older age groups as well as sex differences in
      the level and distribution of missing chromosomes. However, the presence, extent,
      and development course of chromosome loss associated with major modifying
      variables and their interactions, e.g., age, morbidity, sex, environmental
      conditions, remain to be empirically documented. Furthermore, the meaning of
      chromosome loss, including its relationship to mental status, is not clear.

PMID- 1035162
TI  - Immunoglobulin levels and intellectual functioning in the aged.
AB  - Significant positive correlations between vocabulary test scores and serum levels
      of immunoglobulins, IgG and IgM, were obtained for 14 subjects ranging in age
      from 83-100 years (mean 89.0 years). This positive association with vocabulary
      scores is a result contrary to data reported by other investigators. The
      interrelationship between measures of behavior, central nervous system and
      immunologic function deserve further attention.

PMID- 1035163
TI  - Life span characteristics in the male Fischer rat.
AB  - Survival data are reported for 572 male non-breeding Fischer rats, representing
      offspring from brother-sister matings, maintained at a constant temperature and
      humidity, exposed to twelve hours of artificial lighting and to twelve hours of
      darkness per day, and fed a standard laboratory diet ad libitum. The mean
      longevity for these male rats was 642 days and the median longevity was 659 days;
      the longest-lived individual survived to 1192 days. Animals surviving beyond the
      median life span for this colony were found to lose a greater percentage of body
      weight during the last few weeks before death than did shorter-lived animals.
      Offspring born of parents one year of age showed no significant difference in
      longevity from those of three-month old parents. Moreover, the longer any animal
      lived, the greater the maximan weight which he obtained.

PMID- 1035164
TI  - [Effect of heredity and environmental factors on the development of human
      physical work capacity].

PMID- 1035165
TI  - [Several features of the estrous cycle, gonadotropic functions of the pituitary
      and neurosecretory cells of the anterior hypothalamus under conditions of
      cervical sympathectomy].

PMID- 1035166
TI  - [Baroreflex regulation of arterial pressure and regional blood flow during
      emotional stress].
AB  - In unanesthetized cats, the effect of hypothalamic stimulation on the blood
      pressure reflex and blood flow changes in hindlimb and intestine during
      activation of baroreceptors was studied. The stimulation decreased functional
      activity of baroreflex in regard to the blood pressure, while the dilatation of
      hindlimb vessels on hypothalamic stimulation was suppressed by activation of the
      carotid sinuses. Anesthetic drugs alter the hypothalamic regulation of the
      baroreflex.

PMID- 1035167
TI  - Changes of serum gonadotropin concentrations in fetal and neonatal rat following
      castration.
AB  - Changes of serum concentrations of LH were measured in fetal and neonatal rats
      following castration. Intact fetal and neonatal male rats showed low levels of
      serum LH concentration. Though serum LH levels of male rats casterated on the
      20th day of gestation did not significantly increase by the 22nd day of fetal
      age, serum levels of neonatal male rats increased 2-to 3-fold 3 days following
      castration at all ages studied. The increase was greater in 4-day-old male rats
      than in 1-day-old males. The increase of serum LH after castration was also found
      in 4-day-old male rats castrated on the 20th day of gestation. In contrast, serum
      levels of 1-day-old neonatal female rats did not increase 3-days after
      castration. These observations suggest sex differences in maturation of the
      gonadal-hypophyseal feedback mechanism.

PMID- 1035168
TI  - [Comparative study of diagnosis for location of adrenal adenoma in patients with
      primary aldosteronism (author's transl)].
AB  - Four methods; retroperitoneal air insufflation study, adrenal phlebography,
      adrenal scintiscan and estimation of plasma aldosterone in adrenal or renal
      veins, were compared to determine the diagnostic value for the location of
      adrenal adenoma in 27 patients with primary aldosteronism and one with idiopathic
      aldosteronism. The location of adrenal adenoma could be certainly determined, in
      12 of 27 patients with primary aldosteronism by retroperitoneal air insufflation
      study, in 7 of 22 by adrenal phlebography, in 18 of 23 by estimation of
      aldosterone in adrenal or renal vein blood, and in 19 of 27 by adrenal
      scintiscan. From these results, it is concluded that firstly adrenal scintiscan
      with 131I-cholesterol and then adrenal phlebography and estimation of aldosterone
      in adrenal and renal vein blood combined with retroperitoneal air insufflation
      study should be performed for determination of location of adrenal adenoma in
      primary aldosteronism.

PMID- 1035169
TI  - [Metabolism of synthetic corticosteroid esters in man (author's transl)].
AB  - Metabolism of water-soluble synthetic corticosteroid esters, hydrocortisone
      hemisuccinate (H-H); hydrocortisone phosphate (HP), prednisolone hemisuccinate (P
      H), prednisolone phosphate (P-P), dexamethasone phosphate (D-P) and dexamethasone
      sulfate (D-S) was studied by i.v. administration of steroids in a dose of 100 mg
      to 6 healthy volunteers and consequtive urine collections over 24 hrs. Uniary
      metabolites were separated into free, glucuronide, sulfate and "unhydrolyzed"
      fractions and measured by means of Porter-Silber (P-S) reaction and isonicotinic
      acid (INH) reaction. In H-H, H-P and D-S, glucuronide conjugates constituted the
      largest fraction of P-S positive metabolites in 24 hr-urine. In contrast, P-H, P
      P and D-P were excreted mainly as free metabolites. Small but variable portions
      were found as sulfate and "unhydrolized" conjugates. Time course study revealed
      that, in H-H, H-P and D-S, the free/glucuronide ratio of P-S positive metabolites
      decreased progressively or remained low throughout the collection periods,
      whereas in P-H, P-P and D-P the ratio increased markedly in the 4--12 hr period.
      For all steroids, the INH/P-S ratio was found to be high in the free fraction and
      low in the glucuronide fraction; the tendency was especially marked in P-H, P-P
      and d-p. INH-positive metabolites were also predominant in the sulfate and
      "unhydrolyzed" fractions. The results indicate that the metabolism of synthetic
      corticosteroids, in general, is characterized by diminised rate of ring A
      reduction followed by glucuronide conjugation and compensatory increase in free
      metabolites, the bulk of which consists of ring A intact, C-20 reduced
      metabolites. 6-Hydroxylated metabolites may also be increased. Conjugation with
      sulfuric acid occurs but to a small extent. The consistent presence of
      "unhydrolyzed" metabolites suggests that portions of esters can be excreted
      unsplitted. It is also noted that the structure of steroid moieties and type of
      esters were important factors determining the quantitative and qualitative
      difference in their metabolic fates.

PMID- 1035170
TI  - [Estrogen receptor in human endometrium--energy requirement, stability and
      subunit structure-- (author's transl)].
AB  - 1) In our previous paper, it was reported that in human endometrium the step of
      formation of nuclear receptor -estradiol complex was not temperature dependent
      but in rat uteri temperature dependent. In order to clarify whether this
      temperature dependency in rat uteri means an energy requirement for this step or
      not, experiments with 2,4 dinitrophenol as an energy uncoupler were done. Even
      when rat uteri or endometrium of women were incubated with 10 muc of 3H-estradiol
      and 10(-4)M of 2,4-dinitrophenol, 8S estrogen receptor-E2 complex in cytosol and
      5S estrogen receptor-E2 complex in nuclear extract were recognized in both rat
      and woman. Namely, no evidence was recognized for this step to require activation
      energy in rat uterus as well as in human endometrium. 2) The cytosol fraction was
      prepared after human endometrium had been incubated with 3HE2 at 2 degrees C.
      Cytosol was analysed on sucross density gradient after heat treatment (at 10
      degrees C, 31 degrees C or 37 degrees C). At 31 degrees C and 37 degrees C
      treatment, the 8S receptor peak was difficultly recognized. Namely, the 8S
      receptor-E2 complex was heat labile in cell free condition. This appears to be
      one of the reasons why 8S cytosol receptor was not visible in human endometrium
      incubated with 3HE2 at 37 degrees C. 3) When the cytosol fraction from the human
      endometrium was analysed on 3--20% linear sucrose gradient containing 0.4M KCl,
      the 8S peak diminished and about 4S peak appeared. This was considered to mean
      that 8S receptor in human endometrium was also split to a 4S binding unit at high
      salt condition and the 8S receptor in humans had also a subunit structure. 4) 8S
      receptor in cytosol and 5S receptor in nuclear fraction were recognized in one
      case of human endometrial carcinoma, but in another case both receptors were not
      recognized. 5) Estrogen binding protein in human serum was sedimented at 6S
      fraction by sucrose gradient.

PMID- 1035171
TI  - [The reducing effect of prostaglandins on circulating eosinophils in
      splenectomized rats--on its mechanism (author's transl)].
AB  - It is known that Prostaglandins(PGs) have many interesting physiological effects
      on various tissues, but the reducing effect on circulating eosinophils was still
      obscure, except for our report in 1975. Our previous report revealed that the
      effect had not act through beta-adrenergic receptors, because a beta-adrenergic
      blocker did not inhibit this effect. The present report was carried out to study
      whether the hypothalamo-hypophyseal-adrenocortical axis would be concerned or not
      on this effect. PGs(10 mug/kg) were administered intraperitoneally under
      thiopental sodium anesthesia and blood was drawn from the tail vein of the
      splenectomized rats. Both PGE1, E2, F2alpha did not decrease the number of
      peripheral eosinophils on the group of the adrenalectomized rats. Both PGE1,
      F2alpha did not decrease the number of peripheral eosinophils, but PGE2 had a
      significant reducing effect on the number of them 2 and 3 hours after
      administration in the group of the rats with hypothalamic lesions. Both PGE1, E2,
      F2alpha had a significant reducing effect at the group of the rats with man-made
      hypothalamic lesions. This effect was almost the same as for the control group
      just splenectomized. It could be concluded that the eosinopenic effect of PGE1
      and PGF2alpha was conducted through the hypothalamus and adrenal glands, but that
      of PGE2 might be effected through the hypophysis or directly through the adrenal
      glands.

PMID- 1035172
TI  - New combined oral contraceptive with incremental progestogen dosage regimen.

PMID- 1035173
TI  - The influence of rainfall on diet and reproduction in four African rodent
      species.

PMID- 1035174
TI  - [Usefullness of Prolan S in the induction of heat and ovulation in pigs].

PMID- 1035175
TI  - [Effectiveness of Dichlorvos DDVP in the control of cattly pediculosis and its
      effect on treated animals].

PMID- 1035176
TI  - Influence of exogenous phosphorus on uterine fluids composition.

PMID- 1035177
TI  - Sexual behaviour of bulls at pasture: a review.

PMID- 1035178
TI  - Estrous behavior and ovarian activity in peripuberal heifers.

PMID- 1035179
TI  - [Polyblastomatosis of hormone-dependent organs].

PMID- 1035180
TI  - Development of malignant goiter by defatted soybean with iodine-free diet in
      rats.
AB  - Hyperplastic goiters were observed frequently in female rats of Wistar strain
      when given defatted soybean under iodine deficiency for 6 to 12 months. The
      findings in the thyroid were those of malignant tumors in which the features of
      thyroid carcinomas were seen, accompanied with metastasis in the lungs of some
      animals. Enlargement of the thyroid was completely inhibited in rats when a small
      amount of iodine was added to the diet. The role of soybean factor(s) which
      causes enlargment of the thyroid is discussed in relation to the development of
      malignant goiter, together with pathological findings in the animals.

PMID- 1035181
TI  - [Cyclic metabolism of the hypophysis and ovary. Experimental research performed
      with the aid isotopes and atomic absorption].

PMID- 1035182
TI  - On the regularities of distribution of Hypoderma bovis De Geer larvae
      parasitizine cattle herds in different parts of the range of this warble fly.
AB  - The type and parameters of the distribution of the second and third instar larvae
      of Hypoderma bovis in cattle herds in Czechoslovakia (54 herds, 7233 head),
      Mongolia (20 herds, 1809 head) and the USSR (48 herds, 4978 head) were studied. A
      statistical analysis showed a) that in the majority of cases negative binomial
      distribution serves as a model of the distribution of larvae with sufficient
      reliability; b) that the regularity of dependence of the distribution exponent k
      of the negative binomial distribution on the incidence of infestation remains
      constant in different parts of the range of thes warble fly. The latter fact
      indicates that the regulatory systems limiting the population numbers of this
      warble fly are associated with host-parasite relationships and do not depend on a
      complex of conditions specific for various natural zones. In order to understand
      the regulatory processes in parasite populations it is necessary to study equally
      the regulatory mechanisms operating primarily on the level of specimens as well
      as the regulatory systems operating on the level of populations.

PMID- 1035183
TI  - Histopathological changes and the genesis of adiaspiromycomas in mice infected
      intraperitoneally with Emmonsia cresens Emmons et Jellison, 1960.
AB  - Following an intraperitoneal inoculation with a suspension of aleuries of the
      funtus Emmonsia crescens, characteristic adiaspiromycomas originate in the
      abdominal cavity; a generalisation of the infection was caused by lymphogenic and
      haematogenic dissemination. At first, fragments of the mycelium became implanted
      and started to grow on the peritoneum; these were quickly destroyed by a
      gradually increasing leukocytic reaction. In the first month of infection nodules
      were formed mainly on predisposed sites in the abdominal cavity. Inside these
      nodules we found aleuries in the granulation tissue and a necrotic centre
      enclosing the accumulated inoculum. Development was delayed in aleuries released
      from agar particles after their resorption and in aleuries originating from
      remnants of the inoculum. This accounted for an initial heterogeneity of
      spherules in the nodules. The original nodules fus-d and formed large fibrous
      adiaspiromycomas. In the following months atypical spherules produced in large
      numbers by minute, developmentally retarded, budding spherules from the zone
      bordering the centres, were found inside these cel layer succumbed to regressive
      changes. The viability of these large spherules was confirmed by a finding of
      live adiaspores even at as late a time as 19 months after infection.

PMID- 1035184
TI  - [Pharmacological effects of clonazepam, an anticonvulsant, on the central nervous
      system].

PMID- 1035185
TI  - [Effects of psychotropic drugs and the roles of the noradrenergic and
      dopaminergic systems in the lateral hypothalamic self-stimulation behavior].
AB  - A bipolar electrode was stereotaxically implanted in or near the medial forebrain
      bundle at the level of the posterior lateral hypothalamus of male albino Wistar
      Imamichi rats. 1) Two electrode sites implanted in a rat both in the lateral
      hypothalamus and in the dorsal noradrenaline bundle supported self-stimulation
      (SS) behavior. 2) Methamphetamine facilitated the SS dose-dependently in the
      "threshold"-intensity reinforcement. The pretreatment of imipramine enhanced the
      effects of methamphetamine, but that of chlorpromazine inhibited those effects.
      Methamphetamine facilitated the SS also in the moderate-intensity reinforcement.
      Imipramine had no significant effects. On the other hand, chlorpromazine
      inhibited markedly the SS behavior. 3) FLA63 and U-14,624, dopamine beta
      hydroxylase inhibitors, suppressed the SS behavior. Both drugs significantly
      reduced brain norepinephrine levels. FLA63 significantly increased the levels of
      dopamine, but the increase with U-14,624 was not significant. 4) Apomorphine,
      stimulant of dopamine receptor, did not facilitate, but rather suppressed the SS
      in the "threshold"-intensity reinforcement. 5) l-Norepinephrine injected into the
      lateral ventricle facilitated the rate of SS, dose-dependently. On the other
      hand, dopamine had no detectable effects. 7) These results suggest that the
      noradrenergic system in the brain plays a more important role in the positive
      reinforcement of the lateral hypothalamic SS behavior than does the dopaminergic
      system.

PMID- 1035186
TI  - [Roles of noradrenergic and dopaminergic systems in the self-stimulation behavior
      of the substantia nigra].
AB  - A bipolar electrode was stereotaxically implanted in the substantia nigra of male
      albino Wistar-Imamichi rats. 1) Rats lifted and turned their heads and
      contralateral forelimb towards the contralateral side to the electrode during the
      substantia nigral self-stimulation (SS) behavior. 2) Methamphetamine facilitated
      the SS dose-dependently in the "threshold"-intensity reinforcement. The
      pretreatment of imipramine facilitated the effects of methamphetamine. 3) FLA63
      and U-14,624, dopamine beta-hydroxylase inhibitors, suppressed the SS in the
      moderate-intensity reinforcement. 4) Apomorphine, stimulant of dopamine receptor,
      did not facilitate, but rather inhibited the SS dose-dependently in the
      "threshold"-intensity reinforcement. 5) l-Norepinephrine injected into the
      lateral ventricle facilitated the SS dose-dependently. On the other hand,
      dopamine had no marked effects. 6) These results suggest that the noradrenergic
      system in the brain plays a more important role in the positive reinforcement of
      the substantia nigral SS behavior than does the dopaminergicsystem.

PMID- 1035187
TI  - [Pharmacological effects of [(octahydro-2-azocinyl)methyl]
      guanidine(guanazodine): its action mechanism and hypotensive effect].
AB  - Cardiovascular effects of guanazodine, a new antihypertensive drug, in
      anesthetized dogs, rabbits and rats and also isolated atria and arteries were
      compared with those of guanethidine and bethanidine. Guanazodine caused a
      sustained decrease in the systemic blood pressure of spontaneously hypertensive
      rats, renal hypertensive dogs and normal cats. No tachyphylaxis developed when
      the drug was administered orally to the rats once a day for 10 days. The heart
      rate decreased. Guanazodine relaxed the cat nictitating membrane, attenuated the
      positive chronotropic response to sympathetic nerve stimulation in anesthetized
      dogs and in isolated rabbit aorta to transmural electrical stimulation.
      Guazazodine potentiated the pressor response to noradrenaline but attenuated the
      response to tyramine in anesthetized cats. The noradrenaline content of rat
      hearts was significantly reduced 4 hr or later after the injection of
      guanazodine, while the content in brains and adrenal glands was unaffected. The
      LD50 of guanazodine injected intravenously to male rats was 136 +/- 11 mg/kg
      which was approximately 4 times the value of guanethidine and 7 times the value
      of bethanidine. It may be concluded that the hypotensive effect of guanazodine is
      related to adrenergic neuron blocking action, the noradrenaline-depleting action
      in peripheral tissues is similar to the effect of guanethidine and bethanidine,
      and that the extent and the duration of the hypotension induced by guanazodine
      are approximately the same as those with guanethidine but appreciably greater
      than those with bethanidine. Toxicity and side effects appear to be less with
      guanazodine than with guanethidine and bethanidine.

PMID- 1035188
TI  - [Distribution of lithium and its effects on electrolyte and norepinephrine
      metabolism in discrete areas of the rat brain].
AB  - Lithium carbonate (Li2CO3) or lithium chloride (LiCl) was administered to rats,
      and distribution in discrete areas of the brain as well as the effects on
      electrolytes in the urine, blood and whole brain were investigated. Further, the
      effects of Li with or without methamphetamine on electrolytes and norepinephrine
      (NE) metabolism in discrete areas of rat brain were examined. After a single
      administration of Li2CO3 (2.7 mEq/kg p.o.), the Li concentration in all regions
      of the brain except the hypothalamus reached the maximum level at 12 hr and
      decreased gradually. A relatively high concentration was observed in the
      hypothalamus, a short time after the administration. After repeated
      administration of Li2Co3 (2.7 mEq/kg/day for 5 or days p.o.), the Li
      concentration did not increase in any region of the brain in comparison with
      after a single administration and there were no marked changes in the balance of
      electrolytes in the plasma and brain despite significant changes in the urinary
      electrolytes and urine volume. Acute administration of LiCl (2.4 mEq/kg and 1.2
      mEq/kgx2 for 2 hr i.p.) did not affect the levels of NE and its metabolites in
      any region of the brain. Subacute administration of LiCl (2.5mEq/kg X 2/day for
      4.5 days i.p.) concomitant with methamphetamine increased the deaminated
      metabolites of NE in the hypothalamus and hippocampus, whereas no influence was
      observed on the concentrations of sodium and potassium in any region of the
      brain. From these results, it is suggested that the hypothalamus is one area
      where Li exerts its action.

PMID- 1035189
TI  - [Depressive effects of benzodiazepines on penicillin-induced epileptic
      discharges].
AB  - Effects of clonazepam, nitrazepam and diazepam on penicillin induced primary,
      spread and reactive epileptoform discharges were investigated in gallamine
      immobilized cats. Different strengths of seizure foci were induced by penicillin
      G 1000, 3000 and 6000 U injected into the cortex, amygdala and intralaminal
      thalamus, and the spread of epileptic discharges in the subcortex or surrounding
      area and to the contralateral area was followed. Benzodiazepines 5 mg/kg i.v.
      shortened the duration of primary epileptoform discharges and prolonged the
      interictal interval in the cortical, amygdaloid and intralaminal thalamic
      epileptogenesis induced by a high concentration of penicillin G. When a low
      concentration of penicillin G was injected into the cortex, amygdala and
      intralaminal thalamus, benzodiazepines abolished the spread of primary
      epileptoform discharges and the reactive discharges, but did not suppress
      completely the primary epileptogenic discharges and the contralateral reflective
      activity. Suppression of the discharges necessitated administration of a high
      dose. The greatest degree of suppression was seen with clonazepam. It is
      concluded that the anticonvulsive effect of benzodiazepines may be due to the
      blackades of neuronal pathways which spread the seizure discharges from the site
      of origin (focus) to the effector organ, and the elevation of convulsive
      thresholds.

PMID- 1035190
TI  - [Central activity, antihypertensive action and antiulcerogenic effects of
      neurotropin].
AB  - Central activity, antihypertensive action and antiulcerogenic actions of
      Neurotropin (NSP), an extract isolated from vaccinia virus-innoculated skin or
      tissues of rabbits were investigated herein. When actions of NSP were examined in
      isolated muscle preparations by the Magnus-method, peristalsis and ACh-induced
      contraction in the small intestine isolated from crayfish were not influenced,
      peristalsis and ACh-induced contraction in the small intestine from mice were
      slightly accelerated, but adrenaline-induced relaxation in the small intestine
      from mice was not affected. Histamine-induced contraction in the small intestine
      and tracheal muscles isolated from guinea pigs was antagonized slightly, or not
      at all by NSP in a high concentration. NSP had no direct action nor anti-ACh
      action on abdominal muscles from frogs. NSP had no influence on E1-mice
      convulsions. Both spontaneous motor activities and exploratory movements in mice
      were depressed. Sleeping time induced by hexobarbital-Na was prolonged in mice.
      Tremorine-induced tremor in mice was inhibited by NSP, while perphenazine-induced
      catalepsy in rats was not. Normal blood pressure in Wistar rats was not
      influenced, but high blood pressure in SHR (spontaneously hypertensive rats)
      decreased close to normal levels after NSP. NSP had antiulcerogenic effects on
      Takagi's restraint-plus-water-immersing ulcers in rats and histamine-induced
      duodenal ulcers in guinea pigs, but no influence on Shay ulcers in Wistar rats.
      From the data obtained herein, it may be concluded that NSP has many central
      depressant-like activities.

PMID- 1035191
TI  - [Behavioral pharmacology of berberine-type alkaloids. (1) Central depressive
      action of Coptidis rhizoma and its constituents].
AB  - Coptis root is frequently utilized as a sedative in Chinese medicines, however,
      the central depressant action of this compound has not been reported. Such being
      the case, the central depressant actions of methanol extract of coptis root, its
      active ingredients such as non-alkaloids fraction, tertiary base fraction,
      quarternary base fraction, magnoflorine fraction, berberine hydrochloride,
      coptisine hydrochloride and the extract from SAN O SHA SHIN TO being one of the
      preparations which contain coptis root were investigated in mice. The antigastric
      ulcer action of these substances was also examined in rats. All substances were
      given orally. Sontaneous movement and coordinative motor activity were not
      depressed by methanol extract, non-alkaloid fraction quarternary base fraction,
      magnoflorine fraction, berberine hydrochloride, coptisine hhdrochloride and the
      extract from SAN O SHA SHIN TO. There was no inhibition of chemical- and electro
      shock-induced convulsion, morphine induced Straub's tail reaction, apomorphine
      induced masticating motion and aggressive behavior induced by electrical
      stimulation. A loss of righting reflex due to hypnotics was not potentiated by
      the substances. The quarternary base fraction did not elicit central depression,
      while the tertiary base fraction slightly depressed the function of the central
      nervous system. Quarternary base alkaloids such as berberine exerted a slight
      antiulcer effect.

PMID- 1035192
TI  - [Behavioral pharmacology of berberine-type alkaloids. (2) Central depressant
      effects of tetrahydroberberine (THB) and related compounds].
AB  - The behavioral effects of tetrahydroberberine (THB), tetrahydrocoptisine (THC),
      tetrahydropalmatine (THP) and tetrahydrojateorrhizine (THJ) were compared with
      those of chlorpromazine (CPZ) and benzodiazepines in mice and rats. Effects of
      THB were also determined by electroencephalography (EEG) in rabbits. THB was
      found to pharmacologically exert various actions similar to those of CPZ which is
      a major tranquilizer, however, the actions of THB were weaker than those of CPZ.
      Although THB alone did not induce catalepsy, it enhanced the cataleptogenic
      action of CPZ. At a dose over the effective levels, THB did not lower normal body
      temperature or induce muscle relaxation and loss of righting reflex. EEG
      activities in the frontal cortex areas were markedly affected by THB, e.g., fast
      waves in spontaneous EEG were converted to slow waves. THB and CPZ in a similar
      manner elicited a sustaining increase in hippocampal afterdischarge, but the
      action of THB was weaker than that of CPZ. The acute toxicity of THB was lower
      than that of CPZ and benzodiazepines and the depressant activity of THB almost
      equalled that of THC and THP, whereas the activity of 1-THB was 1.5 times as
      great as that of THB. These data indicate that THB, THC and THP may be a new type
      of tranquilizer.

PMID- 1035193
TI  - Monographs on fragrance raw materials.

PMID- 1035194
TI  - [Intramuscular hemangioma. A clinicopathologic observation (author's transl)].

PMID- 1035195
TI  - [A study of urine acid phosphatase in students with proteinuria and patients with
      renal diseases (author's transl)].

PMID- 1035196
TI  - Clinical and biochemical studies on alkaline ribonucleases. I. Purification and
      properties of serum alkaline ribonucleases and urinary alkaline ribonucleases in
      healthy subjects (author's transl).

PMID- 1035197
TI  - [Clinical and biochemical studies on alkaline ribonucleases. II. Urinary alkaline
      ribonucleases of patients with chronic renal diseases (author's transl)].

PMID- 1035198
TI  - The inhibitory effect of hydrocortisone on the chicken embryo cartilage
      somatomedin assay.
AB  - In a study of the effects of hydrocortisone on the embryonic chicken cartilage
      somatomedin assay, in the absence and in the presence of normal human reference
      serum (NHRS), it was found that: (1) The basal uptake of 35S into chicken embryo
      pelvic cartilage was reduced when hydrocortisone hemisuccinate was added to the
      incubation medium in concentrations ranging from 1.5 to 1.5 X 10(5) ng/ml. There
      was a correlation between the inhibitory effect and the quantity of
      hydrocortisone added (r=-0.869; p less than 0.01). (2) The 35S uptake stimulated
      by 1.25 and 5% serum present in the incubation medium was reduced by
      hydrocortisone in a final concentration range of 150-1.5 X 10(5) ng/ml incubation
      medium. The minimal dose was 1,000 times that required to affect the basal 35S
      uptake. (3) When hydrocortisone was directly added to the NHRS, its interfering
      effect on the 35S uptake stimulated by 1.25, 5 and 20% of serum in the incubation
      medium was demonstrable with 5 X 10(5) ng hydrocortisone/ml serum. This
      concentration exceeded the physiological level of hydrocortisone by a factor of
      5,000.

PMID- 1035199
TI  - Familial male internal pseudohermaphroditism; report on a case.
AB  - A rare case of male internal pseudohermaphroditism is described. The patient had
      normal external male sexual characteristics but unilateral cryptorchidism. Three
      of his four brothers had also cryptorchidism and were also involuntary infertile.
      One of them was later operated and a uterus found intra-peritoneallu. The
      patient's parents were cousins and the possible importance of an inheritable
      defect is discussed. The patient's karyotype was normal.

PMID- 1035200
TI  - Studies on the biosynthesis of cyclitols, XXXV. On the mechanism of action of myo
      inositol-1-phosphate synthase from rat testicles.
AB  - The animal myo-inositol-1-phosphate synthase is competitively inhibited by
      pyridoxal phosphate and trinitrobenzensulphonate, both compounds known to prevent
      Schiff's base formation. When incubated with labelled substrate and then treated
      with NaBH4, label can be recovered in the enzyme protein. In analogous
      experiments with tritiated NaBH4 the enzyme protein also becomes labelled; after
      hydrolysis of such protein only one labelled compound, derived from lysine and D
      glucose 6-phosphate, could be isolated. Its exact structure is not yet known.
      From these results it can be concluded that during its action myo-inositol-1
      phosphate synthase forms a Schiff's base with its substrate, in analogy to the
      class I aldolases.

PMID- 1035201
TI  - Synergistic effect of estradiol benzoate and dihydrotestosterone on aggression in
      mice.

PMID- 1035202
TI  - Postpartum aggression in mice: the influence of suckling stimulation.

PMID- 1035203
TI  - Effects of androgen on scent marking and aggressive behavior of neonatally
      bulbectomized female Mongolian gerbils (Meriones unguiculatus).

PMID- 1035204
TI  - The effect of a bacterial extract on synovial cells in tissue culture.
AB  - The studies reported here were undertaken to determine if Erysipelothrix crude
      extract (CE) could elicit consistent, detectable alterations in synovial cells in
      vitro. Synovial cells of rabbits were cultured in vitro and data about normal
      synovial cells in vitro were presented. Such cells were consistently and
      characteristically affected by exposure to small amounts of CE; an effect that
      was neutralized in the presence of specific and anti-CE anti-serum. With an
      increase in the amount of CE added to the cells in culture, a decreasing number
      of cells was formed but protein content remained relatively constant.

PMID- 1035205
TI  - Culture characteristics of cells derived from type II pneumocyte enriched
      fractions from rabbit and rat.
AB  - Type II cell enriched fractions were isolated from rabbit and rat lungs using
      density gradient centrifugation. Cultures established from these fractions
      contained predominantly cells similar in most morphological respects to type II
      pneumocytes. These were in continuous replicating culture for 1 year and still
      exhibited contact inhibition. Membrane-bound structures reminiscent of, but no
      longer strictly identical to, type II cell lamellar cytosomes were seen in cells
      from these long-term cultures although their numbers were reduced in comparison
      to lamellar bodies in freshly isolated cells. Mitochondrial numbers and sizes,
      determined morphometrically, were reduced after culture in comparison to freshly
      isolated type II cells and those in situ. Phosphatidylcholine was synthesized by
      these cells and released into the extracellular medium. Application of laser
      activated electronic sizing data, confirmed by direct micrometry, demonstrated a
      significant increase in cell size as a function of culture. This sizing data,
      after prior confirmation by electron microscopy, was used as an aid in
      identifying type II cells and macrophages in dispersion, especially with those
      cells derived from rabbit lungs.

PMID- 1035206
TI  - [Clinical picture, pathophysiology and therapy of idiopathic thrombocytopenic
      purpura (author's transl)].
AB  - A review of the clinical picture, the therapy and the pathophysiology of
      idiopathic thrombocytopenic purpura (ITP) is presented. Emphasis is put on recent
      evidence concerning cellular and humoral autoimmune reactions, and their
      relevance for the pathogenesis of the disease is outlined.

PMID- 1035207
TI  - A clinico-pathological study of urinary tract malformations in perinatal deaths.

PMID- 1035208
TI  - Diagnostic aspects of bladder angiography in urinary bladder tuberculosis.
AB  - Histopathological and angiographic findings were correlated in 6 cases of
      tuberculosis of the urinary bladder. The number of vessels was only slightly
      increased in the initial and fibrotic stages, whereas hypervascularization was
      observed in the exudative and productive stages. Otherwise the angiographic
      changes were nonspecific. Thus it was not possible to distinguish tuberculous
      cystitis from cystitis of other genesis, and in some instances from tumours of
      the urinary bladder either.

PMID- 1035209
TI  - Malignant testicular tumors in three  brothers.
AB  - Three brothers out of four had malignant testicular tumors. The first of them had
      choriocarcinoma, the second seminoma, and the third teratocarcinoma of the
      testis.

PMID- 1035210
TI  - Patterns of labor in native and immigrant population in Israel.
AB  - The application of cervical dilatation rates as a predictive index of the outcome
      of labor was tested among various subgroups of the Israel population. Cervical
      dilatation rates, gestational ages, birth weights, initial fetal head station,
      cervical dilatation at head engagement, and incidence of delivery problems were
      similar among Jewish patients, both native born and foreign; and among Arab
      patients. Generally, primiparas entered labor with lower fetal head station and
      reached head engagement with less cervical dilatation than did multiparous or
      grand multiparous patients. The results suggest that the rate of cervical
      dilatation, as measured early in the active phase of labor, can be used with
      equal confidence among all our population groups to forecast type of delivery.
      Early in the active phase of labor, women in whom the probability of a
      spontaneous delivery is approximately 95% can be separated from those cases in
      which intervention will be necessary.

PMID- 1035211
TI  - Cerebral distress in full-term newborns and its prognostic value. A follow-up
      study of 90 infants.
AB  - The history of 90 full-term infants with neonatal cerebral distress was examined.
      Informations concerning pregnancy, delivery, neonatal status, clinical and
      laboratory evolution were compared with final outcome in each case. It was then
      possible to distinguish certain clinical features significantly associated with
      poor prognosis. After statistical analysis, different adverse criteria were
      selected, such as severe neonatal asphyxia, associated respiratory disorders,
      acute anemia, and especially neurological signs with regard to their chronology.
      This part of the study has resulted in a classification of the neurological signs
      and has permitted the description of both malignant and benign cerebral distress
      syndromes.

PMID- 1035212
TI  - [Sugar consumption and prenatal acceleration. II. Studies on the etiology and
      pathophysiology of secular prenatal acceleration].
AB  - The pathophysiologic considerations support the causal relationship between the
      secular trend of sugar consumption in industrialized society and the development
      of prenatal acceleration, which is evident on the basis of epidemiological data.
      The excessive consumption of sugar and the other quickly absorbed "refined"
      carbohydrates enhances the hormonogenic effect of food which is also potentiated
      by the proteins. Together with the caloric overloading, provoked also by the
      excess in fat, characteristic for the affluent society, the excessive sugar
      consumption enhances in the pregnant women obesity and "protodiabetes"
      (PFEIFFER), in the predisposed child the tendency to hyperinsulinism with its
      consequences. In a prediabetic mother with normal glucose-tolerance the regularly
      repeated postprandial overfloating of the fetus with maternal glucose changes the
      feto-maternal hormonal regulation and enhances together with the overloading of
      substrate, i.e. energy and elements of biosyntheses, the accelerated fetal growth
      and especially the obesity of the large baby.

PMID- 1035213
TI  - The ultrastructure of the fungus Trichoderma viride and investigation of its
      growth on cellulose.

PMID- 1035214
TI  - Effect of temperature and added polyphosphate on the survival of salmonellae in
      poultry meat during cold storage.

PMID- 1035215
TI  - Sulfate incorporation from ascorbate 2-sulfate into chondroitin sulfate by
      embryonic chick cartilage epiphyses.
AB  - Radioactivity was significantly incorporated from ascorbate 2-[35S]sulfate into
      chondroitin sulfate by embryonic chick cartilage epiphyses. The extent of
      incorporation was comparable with that from inorganic [35S]sulfate. The
      radioactive chondroitin sulfate formed from ascorbate 2-[35S]sulfate gave two
      radioactive disaccharides on chondroitinase-ABC [EC 4.2.2.4] digestion. The
      incorporation was markedly decreased by inorganic sulfate. The time course of
      incorporation from ascorbate 2-[35S]sulfate and inorganic [35S]sulfate into
      chondroitin sulfate and the constituent disaccharides suggest that the
      incorporation rates from the two radioactive substances are different.

PMID- 1035216
TI  - Studies on the hydrazinolysis of glycoproteins. Core structures of
      oligosaccharides obtained from Porcine thyroglobulin and pineapple stem
      bromelain.
AB  - Hydrazinolysis of porcine thyroglobulin glycopeptides and of pineapple stem
      bromelain [EC 3.4.22.4] permitted the isolation of almost intact carbohydrate
      chains of these glycoproteins. On the basis of permethylation analyses of the
      released oligosaccharides after reduction with NaBH4, the core structures of Unit
      A-type and Unit B-type carbohydrate chains of porcine thyroglobulin were deduced
      to be Manalpha1 leads to 6[Manalpha1 leads to 3]Manbeta1 leads to 4GlcNAcbeta1
      leads to 4[Ralpha1 leads to 6]GlcNAc leads to Asn (Unit A-type, R=H; Unit B-type,
      R=Fuc), and that of bromelain was found to be Manalpha1 leads to 6[R'1 leads to
      2]Manbeta1 leads to 4GlcNAcbeta1 leads to 4[R1 leads to 3]GlcNAc leads to Asn
      (R'=Xylbeta and R=Fucalpha, or R'=Fucalpha and R=Xylbeta). From these results, it
      appears that the hydrazinolysis method is applicable to wide variety of
      glycoproteins which have an N-glycosylamine linkage between the carbohydrate and
      peptide moieties, regardless of the type of linkage to the most proximal N
      acetylglucosamine residue which is bound to asparagine.

PMID- 1035217
TI  - Bovine plasma HMW and LMW kininogens. Structural differences between heavy and
      light chains derived from the kinin-free proteins.

PMID- 1035218
TI  - Isolation of two forms of activated C1s, a subcomponent of the first component of
      rabbit complement.
AB  - Two forms of activated C1s, a subcomponent of the first component of complement,
      were present in preparations of C1 specifically purified from rabbit serum by
      affinity chromatography on IgG-Sepharose 6B and were separated by DEAE-cellulose
      chromatography in the presence of EDTA. These two activated C1s, designated
      C1s(I) and C1s(II), were indistinguishable with regard to hemolytic activity as
      well as C1s esterase activity, though they had different molecular weights.
      C1s(I) had a molecular weight of 106,000, consisting of H and L chains connected
      by disulfide bonds; the molecular weights of the chains were 70,000 and 36,000,
      respectively. On the other hand, C1s(II), with a molecular weight of 72,000,
      consisted of two chains each with a molecular weight of about 37,000, which were
      also connected by disulfide bonds. These results suggest that, in the case of
      rabbit C1s, the primary product of activation with C1r, C1s(I), may be
      susceptible to further cleavage of its H chain without any loss of C1s activity,
      resulting in the formation of C1s(II), though the active principle responsible
      for this conversion remains to be elucidated.

PMID- 1035219
TI  - Classification of loops of lampbrush chromosomes according to the arrangement of
      transcriptional complexes.
AB  - The arrangement of transcriptional units in the loops of lampbrush chromosomes
      from oocyte nuclei of urodele amphibia and from primary nuclei of the green alga
      Acetabularia have been studied in the electron microscope using spread
      preparations. Loops with different patterns of arrangement of matrix units (i.e.
      to a first approximation, transcriptional units) can be distinguished: (i) loops
      consisting of one active transcriptional unit; (ii) loops containing one active
      transcriptional unit plus additional fibril-free, i.e. apparently untranscribed,
      intercepts that may include 'spacer' regions; (iii) loops containing two or more
      transcriptional units arranged in identical or changing polarities, with or
      without interspersed apparent spacer regions. Morphological details of the
      transcriptional complexes are described. The observations are not compatible with
      the concept that one loop reflects one and only one transcriptional unit but,
      rather, lead to a classification of loop types according to the arrangement of
      their transcriptional units. We propose that the lampbrush chromosome loop can
      represent a unit for the coordinate transcription of either one gene or a set of
      several (different) genes.

PMID- 1035220
TI  - Scanning electron-microscopical and other observations of sperm fertilization
      reactions in Limulus polyphemus L. (Merostomata: Xiphosura).
AB  - Sperm fertilization reactions of Limulus polyphemus were examined by scanning
      electron and/or light microscopy. The following were considered: sperm motility,
      attachment of sperm to egg, acrosome reaction, and penetration of the acrosomal
      filament. The spermatozoa after semination are non-motile and become active only
      in close proximity to a defined region surrounding the egg. Egg materials
      diffusing into this region induce sperm motility and stimulate large numbers of
      spermatozoa to move towards the egg surface. Each sperm initially attaches by the
      apical tip and undergoes the acrosome reaction which causes a more permanent
      secondary attachment by the adhesion of acrosomal contents to the egg surface.
      The acrosome reaction also initiates the penetration of the acrosomal filament
      through the egg envelope, an event occurring in 70-80% of the attached
      spermatozoa (about 10(6). Shortly after this penetration, a secondary reaction
      occurs which involves a spiralling of the flagellum and an incorporation into the
      sperm body of the flagellar fibrous components, which then become closely apposed
      to the sperm nucleus. These sperm fertilization reactions were performed or
      initiated with 0-34 M CaCl2 in whole eggs, egg sections, excised egg envelopes
      and/or the outer basement lamina of the egg envelope. The Limulus fertilization
      system is very valuable since sperm reactions can be examined biochemically,
      which may lead to a better understanding of the chemical mechanisms involved in
      sperm-egg interactions in all animal species.

PMID- 1035221
TI  - Signal emission and signal propagation during early aggregation in Dictyostelium
      discoideum.
AB  - Waves of chemotactic movement during the early phase of aggregation in
      Dictyostelium discoideum are of 2 kinds, concentric waves produced by cells that
      emit cyclic AMP signals spontaneously, and spirals generated by excitations
      relayed continuously around loops of excitable cells. The period of a spiral wave
      is the time taken for the excitation to make one complete circuit of the
      pacemaker loop. We have compared signal emission from the 2 types of source in
      time-lapse films made at a variety of temperatures. Our results show that spiral
      waves have a characteristic period length throughout most if not all of the early
      phase of aggregation, and that the period of concentric waves is generally longer
      and more variable. Temperature has a pronounced effect on period length and a
      lesser effect on propagation velocity. We find that each individual wave is
      propagated at constant velocity over distances of 1-2 cm but that the velocity of
      successive waves declines. This decline probably reflects some cumulative effect
      of the chemotactic excitations on the excitable properties of the aggregating
      cells.

PMID- 1035222
TI  - [Spine-distribution of pyramidal neurons of the CAl-region of the rat hippocampus
      following long-term oral alcohol administration].
AB  - The distribution of the dendritic spines in the CA1 hippocampal region of adult
      rats was investigated by means of lightmicroscopical and statistical methods. The
      rats received daily equal amounts of aethanol for a period of 52 days. The
      average number of spines for a part of 50 mum along the apical main dendrite
      raised from 35 to 36.9 spines. The average spines-density for a part of 1 mum
      length on the apical dendritic branches raised from 0.71 to 0.94 spines. In a
      similar way the average spines-density on the basal dendritic branches raised
      from 0.65 to 0.94 spines. According to our results received after a period of
      aethanol application the total number of dendritic spines of one rat CA1
      hippocampal pyramidal neuron was calculated with 4177 visible spines. The value
      was compared with the normal value of 3029 dendritic spines. The results were
      discussed by the aid of additional light- and electronmicroscopical findings.

PMID- 1035223
TI  - Angiosarcoma of pelvis presenting clinically as tuberculosis of hip.

PMID- 1035224
TI  - [Mycoardial protection during open-heart surgery under extracorporeal circulation
      with special reference to selective coronary porfusion with cold blood at a low
      flow rate].

PMID- 1035225
TI  - [Clinical evaluation of heterograft valve implantation].

PMID- 1035226
TI  - [Studies of carbohydrate metabolism associated with open-heart surgery-comparison
      between simple deep hypothermia and extracorporeal circulation].

PMID- 1035227
TI  - [Congenital coronary artery fistula. Compilation and evaluation of cases reported
      in Japan].

PMID- 1035228
TI  - [Experimental and clinical studies on xenograft of the cardiac valves].

PMID- 1035229
TI  - [Pathohistological studies of right ventricular hypertrophy in tetralogy of
      Fallot].

PMID- 1035231
TI  - [Experimental studies on the effect of left ventricular aneursym on left
      ventricular function and diagnostic index pathogenomonic of aneurysm].

PMID- 1035230
TI  - [Doubled-chambered right ventricle combined with anterior leaflet aneurysm of the
      tricuspid valve and complete absence of the left pericardium].

PMID- 1035233
TI  - [Panel discussion: Non-invasive cancer and its pathology at the peripheral
      region].

PMID- 1035232
TI  - [Changes in C-reactive protein(CRP) levels, leukocyte count, and blood
      sedimentation rate following cardiac pacemaker implant].

PMID- 1035234
TI  - [Serum complement in malignant tumors of the head and neck (author's transl)].

PMID- 1035235
TI  - Two comparisons of statistical methods for comparing the results of cancer
      therapy (author's transl).

PMID- 1035236
TI  - Comparative study on cytological differences between high- and low-metastatic
      cloned cell lines of rat uterine adenocarcinoma.

PMID- 1035237
TI  - Endocrinological and clinicopathological studies on medullary thyroid carcinoma.
      Part 1: Preoperative diagnosis of medullary thyroid carcinoma--physical and
      roentgenologic findings and determination of plasma calcitonin level (author's
      transl).

PMID- 1035238
TI  - [Acute renal failure and its treatment (author's transl)].

PMID- 1035239
TI  - [Advance in diagnosis and therapy of hypochromic anemia (author's transl)].

PMID- 1035240
TI  - [Symposium on the cerebral stroke. (1) General introduction of epidemiological
      aspects on cerebrovascular disease in Japan (author's transl)].

PMID- 1035241
TI  - [Symposium on the cerebral stroke. (2) The 15 year follow-up population survey on
      cerebrovascular disease in rural Kyushu, Japan (author's transl)].

PMID- 1035242
TI  - Symposium on the cerebral stroke. (3) Effects of long-term managements of the
      risk factors on primary prevention of cerebrovascular diseases (author's transl).

PMID- 1035243
TI  - Symposium on the cerebral stroke. (4) Studies on influences of serum lipoprotein
      and hypertension in cerebrovascular disorders (author's transl).

PMID- 1035244
TI  - Symposium on the cerebral stroke. (5) Studies on the aspect of plasma fibrinogen
      and serum lipids relating to apoplexy (author's transl).

PMID- 1035245
TI  - [(6) Disseminated intravascular coagulation syndrome and cerebrovascular diseases
      (author's transl)].

PMID- 1035246
TI  - [Symposium on the cerebral stroke. (7) Clinicopathological and experimental study
      on the pathogenesis of cerebral vascular disease---with special reference to the
      role of venous circulatory disturbance (author's transl)].

PMID- 1035247
TI  - [Symposium on the cerebral stroke. (8) Studies on the foresight and prevention of
      cerebrovascular diseases--from the examination on the cardiovascular system of
      the adults (author's transl)].

PMID- 1035248
TI  - [Symposium on the cerebral stroke. (9) Rehabilitation service in improving the
      disease course and prognosis for patients with apoplexy: a ten year follow-up
      study (author's transl)].

PMID- 1035249
TI  - [Changes in hemodynamic parameters in exercise tests--analysis with hemodynamic
      changes as functions of time (author's transl)].

PMID- 1035250
TI  - [Factors precipitating cerebrovascular accident (author's transl)].

PMID- 1035251
TI  - [A case report of diabetic neuroarthropathy (author's transl)].

PMID- 1035252
TI  - [A case of type II cystinuria (author's transl)].

PMID- 1035253
TI  - [A case of sarcoidosis with Marin-Amat syndrome (author's transl)].

PMID- 1035254
TI  - The role of environmental calcium in freshwater survival of the marine teleost,
      Lagodon rhomboides.
AB  - (1) The marine teleost fish, Lagodon rhomboides, can only tolerate fresh water (5
      mM Na) if Ca is also present (10 mM). Transfer to Ca-free fresh water is followed
      by a substantial increase in radioactive Na efflux with little or no change in
      the transepithelial potential. Addition of the chelating agent EDTA (2 mM)
      further increases Na efflux. Fish left in Ca-free fresh water for 2-5 h die with
      a total body Na less than 50% of that found in animals acclimated to Ca
      supplemented fresh water. (2) Rates of Na uptake were measured on either sea
      water-acclimated or Ca-supplemented fresh water-acclimated fish transferred to
      various low Na media. In both cases Na uptake has a high Km, is saturable,
      inhibited by external NH4, H and amiloride, and is not related to changes in the
      trans-epithelial potential. (3) It is suggested that L. rhomboides is dependent
      upon external Ca to decrease diffusional Na loss in low salinities so that a
      relatively inefficient Na uptake can balance diffusional and urinary Na loss.

PMID- 1035255
TI  - Altered calcium conductance in pawns, behavioural mutants of Paramecium aurelia.
AB  - Pawns are behavioural mutants (in one of three genes) of Paramecium aurelia that
      have lost, to varying degrees, the reversal response which is thought to depend
      on the calcium influx during excitation. This report shows that all of the single
      and double mutants have reduced active inward (calcium) current, the reduction
      correlating with the degree of behavioural deficit. All of the mutants display
      normal resting potential, input impedance and delayed rectification. Mutants in
      genes pwA and pwC show normal anomalous rectification, but pwB mutants do not
      show anomalous rectification until the membrane is hyperpolarized further. We
      suggest that the pwA gene plays a role in depolarization sensitivity (the 'gate')
      and the pwB gene a role affecting either the wall of the channel itself or the
      total number of channels.

PMID- 1035256
TI  - Calcium channel stability measured by gradual loss of excitability in pawn
      mutants of Paramecium aurelia.
AB  - Mutants of Paramecium aurelia that are unable to reverse swimming direction are
      called pawns. They lack the inward ionic (calcium) current required for the
      upstroke of the electrically excitable membrane response. By following the
      progressive loss of reversal response and excitability in cells that are suddenly
      changed from a heterozygous (wild-type) state to a homozygous mutant state, an
      estimate of the stability and mean lifetime of the calcium channel has been
      obtained. During rapid growth, channel dilution due to division occurred, but no
      channel decay was observed. Under conditions of slow growth, decay could also be
      observed; channel lifetime was found to be from 5 to 8 days.

PMID- 1035257
TI  - [Auditory middle latency response (author's transl)].

PMID- 1035258
TI  - [Schematical presentation of vibration of pathological vocal cords (author's
      transl)].

PMID- 1035259
TI  - [Pathophysiological and clinical studies on the effect of tympanoplasty
      (supplementary studies)-aspects on the eustachian tube (author's transl)].

PMID- 1035260
TI  - [Analysing techniques of the center of gravity-area occupied and length of lucus
      followed by the center of gravity- (author's transl)].

PMID- 1035261
TI  - [Function of the external laryngeal muscles in laryngeal adjustment (author's
      transl)].

PMID- 1035262
TI  - [A simultaneous recording system of E.M.G. and X-ray T.V. for investigation of
      deglutition (author's transl)].

PMID- 1035263
TI  - [Electron microscopic study on the laryngeal polyp (author's transl)].

PMID- 1035264
TI  - [A case of late congenital syphilitic labyrinthitis-with reference to Hennebert's
      sign, fluctuating hearing, Herxheimer reaction and therapeutic response of
      impaired hearing (author's transl)].

PMID- 1035265
TI  - [Clinical anatomy of the teeth (maxillary teeth)].

PMID- 1035266
TI  - Growth of fertilized one-cell rabbit ova to viable morulae in the presence of
      pyruvate or fatty acids [proceedings].

PMID- 1035267
TI  - Effects of removing foetuses from pregnant rat uteri on uterine collagen content
      [proceedings].

PMID- 1035268
TI  - [Effects of K+ or norepinephrine on oxygen uptake in brown adipose tissue
      (author's transl)].
AB  - This investigation was undertaken to clarify the mechanism of the stimulated-
      respiration caused by K+ or norepinephrine in brown adipose tissue. 1. The
      addition of 30 approximately 100 mM K+ stimulated remarkably oxygen uptake in
      brown adipose tissue, and similarly norepinephrine (0.1 or 1.0 mug/ml) caused a
      marked stimulation. 2. Even if Na+ in normal Ringer solution was replaced by
      Choline or Li+, oxygen uptake caused by K+ (30 mM) or norepinephrine (1.0 mug/ml)
      was unaffected. 3. K+ -induced oxygen uptake was not observed when a Ca2+ 
      deficient tissue was incubated in Ca2+ -free Ringer, while norepinephrine-induced
      oxygen uptake clearly observed. And the oxygen uptake of Ca2+ -deficient tissue
      due to K+ was recovered by the addition of 5 mM Ca2+. 4. Mn2+ (6 mM) or La3+ (10
      mM) inhibited significantly oxygen uptake due to K+, but not oxygen uptake due to
      norepinephrine. 5. K+ -induced oxygen uptake was unaffected by 10(-4) or 10(-3)M
      ouabain, but norepinephrine-induced oxygen uptake was inhibited considerably by
      10(-4)M ouabain. 6. The oxygen uptake due to K+ was unaffected by propranolol (33
      muM), whereas that due to norepinephrine was significantly inhibited in the
      presence of propranolol. 7. In the tissue from reserpine-treated animal, the
      oxygen uptake caused by K+ was observed. According, from these positive results
      we are justified to suggest that K+ -induced oxygen uptake is dependent on the
      presence of Ca2+, and not always caused by catecholamines released secondarily
      from nerve terminal.

PMID- 1035269
TI  - Blood flow of the lower limb in maximal treadmill and bicyle exercise.

PMID- 1035270
TI  - Fluid therapy in canine babesiosis.

PMID- 1035271
TI  - [Effect of vincristine in idiopathic thrombocytopenic purpura (author's transl)].

PMID- 1035272
TI  - [Studies on in vitro colony formation in children with aplastic anemia. II.
      Effect of adherent cell on in vitro colony formation in children with aplastic
      anemia (author's transl)].

PMID- 1035273
TI  - [Myelofibrosis probably secondary to splenic tuberculosis: report of a case
      (author's transl)].

PMID- 1035274
TI  - [An autopsied case of clinically diagnosed acute myelofibrosis (author's
      transl)].

PMID- 1035275
TI  - [IgA myeloma with antistreptolysin-O activity (author's transl)].

PMID- 1035276
TI  - [A case of cyclic neutropenia with special reference to the function of
      neutrophil mobilization (author's transl)].

PMID- 1035277
TI  - [Etiological mechanism of autoimmunity, with special reference to the endocrine
      organs].

PMID- 1035278
TI  - [Autoimmunity related to diabetes and insulin, with special reference to insulin
      autoimmunity syndrome].

PMID- 1035279
TI  - [Autoimmune oophoritis and its consequences].

PMID- 1035280
TI  - [Successful transplantation and functional maturation of the human thymus gland
      to the nude mouse].

PMID- 1035281
TI  - [Thymus gland and endocrinology].

PMID- 1035282
TI  - [Thymus gland and thymus hormones].

PMID- 1035283
TI  - [Congenital heart defects].

PMID- 1035284
TI  - [Surgical management of mitral valve disease, with special reference to mitral
      valve replacement].

PMID- 1035285
TI  - Theoretical and therapeutic potential of indoleamine precursors (4).

PMID- 1035286
TI  - [Diseases of the mucous membrane. (1)].

PMID- 1035287
TI  - [Chemistry of somatostatin].

PMID- 1035288
TI  - [Action mechanism of somatostatin].

PMID- 1035289
TI  - [Effects of somatostatin on the pituitary gland].

PMID- 1035290
TI  - [Effects of somatostatin on the pancreas].

PMID- 1035291
TI  - [Feedback in the neurosecretory system].

PMID- 1035292
TI  - [Feedback regulation in the pituitary-adrenocortex system in rat fetus and
      neonates].

PMID- 1035293
TI  - [Negative feedback caused by thyroid hormones].

PMID- 1035294
TI  - [Estrogen positive feedback and its abnormality].

PMID- 1035295
TI  - [3 cases of Laurence-Moon-Biedl syndrome, with special reference to glucose
      tolerance].

PMID- 1035296
TI  - [Diagnosis of bladder neoplasms].

PMID- 1035297
TI  - [Serum carcinoembryonic antigen in bladder neoplasms].

PMID- 1035298
TI  - [Test by quantitative estimation (author's transl)].

PMID- 1035300
TI  - [Topics of pulmonary function tests (author's transl)].

PMID- 1035299
TI  - [Urinalaysis and other routine examinations (author's transl)].

PMID- 1035301
TI  - [Topics of clinical neurophysiology (author's transl)].

PMID- 1035302
TI  - [Clinical virology (author's transl)].

PMID- 1035303
TI  - [Blood transfusion, especially topics of blood group types (author's transl)].

PMID- 1035304
TI  - [Blood morphology (author's transl)].

PMID- 1035305
TI  - [Radionuclide cisternography].

PMID- 1035306
TI  - [Evaluation of 99mTC-HSA prepared by a new labeling method].

PMID- 1035307
TI  - [Primary empty sella with special reference to roentgenological anatomy].

PMID- 1035308
TI  - [Study of cholecysto- and cholangiography using BC-17 -- usefulness of
      zonography].

PMID- 1035309
TI  - [Radiotherapy of esophageal neoplasms].

PMID- 1035310
TI  - [Angiographic findings of giant retrocerebellar arachnoid cyst in an infant].

PMID- 1035311
TI  - [Marfan's syndrome with ascending aortic aneurysm and aortic valve insufficiency 
      autofluoroscopic diagnosis].

PMID- 1035312
TI  - [Intraduodenal choledochal cyst].

PMID- 1035313
TI  - [Hepatic hemangioma with peculiar findings in the hepatic radioisotope angiogram
      and blood pool scintigram].

PMID- 1035314
TI  - [Diagnosis of milk of calcium renal stone by percutaneous puncture and
      aspiration].

PMID- 1035315
TI  - [Clinical studies on the procedure of autotomography in pneumoencephalography].

PMID- 1035316
TI  - [Boerhaave's syndrome].

PMID- 1035318
TI  - [Filling system for records of radiotherapy for cancer and computation of the
      survival rate from the file].

PMID- 1035317
TI  - [Adrenal scintigraphy. (2) Primary aldosteronism].

PMID- 1035319
TI  - [Bilirubin metabolism in obstructive jaundice. (1) Renal excretion of bilirubin].

PMID- 1035320
TI  - [Prognosis of gastric cancer resection. (II) Clinical and pathohistological
      investigation on the mode of vascular invasion].

PMID- 1035321
TI  - [Endocrine pancreatic dysfunction in chronic pancreatitis, with special reference
      to glucagon and insulin secretion during intravenous infusion of arginine].

PMID- 1035322
TI  - [Experimental pancreatic lithiasis - the effect of incomplete ligation of the
      pancreatic duct on changes of the pancreatic juice composition].

PMID- 1035323
TI  - [Alkaline phosphatase isoenzymes in cancerous tissue of  the stomach].

PMID- 1035324
TI  - [Secretin release caused by oral administration or duodenal infusion of 1-phenyl
      1-hydroxy-n-pentane].

PMID- 1035325
TI  - [Serum gastrin concentration in gastroduodenal diseases. (Fasting serum gastrin
      concentration)].

PMID- 1035326
TI  - [Radioimmunoassay of serum ferritin and its clinical implication in diseases of
      the digestive organs].

PMID- 1035327
TI  - [Endoscopic and clinical studies on lymph follicles of the rectum].

PMID- 1035328
TI  - [Immunological studies on ulcerative colitis. (I) Humoral immunity].

PMID- 1035329
TI  - [Meckel's diverticulum and its preoperative roentgen diagnosis].

PMID- 1035330
TI  - [Primary sclerosing cholangitis--a case report (author's transl)].

PMID- 1035332
TI  - [Eco-geographical aspects of the twin birth rate].

PMID- 1035331
TI  - [A case of systemic lupus erythematosus associated with persistent p-type
      hyperamylasemia during steroid therapy (author's transl)].

PMID- 1035333
TI  - [A statistical study on mobility of lumbar spine (author's transl)].

PMID- 1035334
TI  - [Hygienic studies on residential mode in some public apartment houses (author's
      transl)].

PMID- 1035335
TI  - [Effect of phthalate ester on reproductive performance in rat (author's transl)].

PMID- 1035336
TI  - [Difference in smoking habits between Japanese in Japan and those in Hawaii and
      its relation to lung cancer risk (author's transl)].

PMID- 1035337
TI  - Position of axial triradius in 51 cases of 47, XXY Klinefelter's syndrome.

PMID- 1035338
TI  - Correlation coefficients of pattern intensity of fingers (PI) in twin families.

PMID- 1035339
TI  - [The zygosity diagnosis of Japanese twins by dermatoglyphic features (author's
      transl)].

PMID- 1035340
TI  - Chromosome 8 trisomy mosaic syndrome.

PMID- 1035341
TI  - The demonstration of the silent PGM allele in a Japanese family.

PMID- 1035342
TI  - Further studies on phosphoglucomutase-1 phenotypes in Japanese. i. Comparison of
      "slow" variants.

PMID- 1035343
TI  - A genetic study of orthostatic responses and orthostatic dysregulation.

PMID- 1035344
TI  - [New method of x-ray imaging--computer tomography].

PMID- 1035345
TI  - [Automatic interpretation of the brain wave].

PMID- 1035347
TI  - [Externally powered artificial limbs--finger-tip mechanism of the artificial
      arm].

PMID- 1035346
TI  - [Collagen fiber electrode for recording of the peripheral nerve activities].

PMID- 1035348
TI  - [Polynomial model for the circulatory system].

PMID- 1035349
TI  - [Guide for designing the electropupillometer].

PMID- 1035350
TI  - [Cardiac flow wave calculator].

PMID- 1035351
TI  - [Long-term continuous ECG recorder].

PMID- 1035352
TI  - [Reliability of laboratory tests--present status of laboratory chemical tests].

PMID- 1035353
TI  - Activation of therminal components of human complement by a trypsin-activated
      complex of human factor B and cobra venom factor.
AB  - Cleavage of C3 by CVF-B was demonstrated by hemolytic, immunoelectrophoretic and
      immune adherence reactions. No cleavage of C5 was detected by
      immunoelectrophoresis, but C5 hemolytic activity, assayed with EAC1423, decreased
      although less than C3 hemolytic activity. The co-existence of C3 with limiting
      amounts of C5 did not reduce the final degree of hemolysis of guinea pig
      erythrocytes (GPE) induced by late-acting components C6 through C9 and CVF-B.
      Thus, a CVF-B hemolytic system composed of GPE, C5 through C9 and CVF-B provided
      a method for titration of terminal components of human complement. CVF-B was able
      to generate hemolytically active sites of C567 on GPE by activation of C5, C6 and
      C7. The complex C567 in the fluid-phase decayed within 1 min but C567 on GPE was
      quite stable. Originally insensitive sheep erythrocytes became sensitive to the
      CVF-B hemolytic system if C3b sites were present, suggesting that cell-bound C3b
      played a role in orienting the positions of C567 to be fixed. CVF-B could be
      recovered quantitatively from the supernatant of the reaction mixture in which
      the hemolytically active intermediate GPEC-5678 had been formed through the
      interaction between C5 to C8 and CVF-B.

PMID- 1035354
TI  - [Risk period for the recurrence of nephrotic syndrome with minimal change in
      adults].

PMID- 1035355
TI  - The pharmacological basis for modern diuretic therapy.

PMID- 1035356
TI  - Renal physiology from past to present.

PMID- 1035357
TI  - [Bone mineral analysis by bone mineral analyzer].

PMID- 1035358
TI  - [Radioimmunoassay of carcinoembryonic antigen (CEA, Gold). Clinical and
      experimental studies on CEA RIA kit (Dainabot)].

PMID- 1035359
TI  - [Comparative study of adrenal gland scanning agents, 6beta-iodomethyl-19-nor
      cholest-5(10)-en-3beta-o1-131I (NCL-6-131I) and 131I-19-cholesterol (CL-19
      131I)].

PMID- 1035360
TI  - [Detection of the obstructed site in the ventricular shunt--experimental
      studies].

PMID- 1035361
TI  - [Myocardial scintigraphy and myocardial blood flow measurement with 201T1].

PMID- 1035362
TI  - [Macroautoradiographic distribution of prostaglandin F2-alpha in pregnant mice].

PMID- 1035363
TI  - [Experimental and clinical studies of thyroxine RIA kit].

PMID- 1035364
TI  - [Studies of the cerebrospinal fluid with lllIn-DTPA cisternography and
      myelography].

PMID- 1035365
TI  - Improvement of findings on bone image in prostatic cancer following testosterone
      potentiated 32P therapy.

PMID- 1035366
TI  - [2 cases of hypertrophic pulmonary osteoarthropathy with a positive image on
      99mTc-EHDP bone scintigraphy].

PMID- 1035367
TI  - [Radioisotope scanning of the lacrimal apparatus].

PMID- 1035368
TI  - An attempt to create spleno-systemic anastomosis in the rat.
AB  - A selective diversion of the splenic venous flow into the systemic circulation
      was attempted in the rat. A combination of the subcutaneous splenic transposition
      and the ligation of the splenic vein as a two stage operation was carried out in
      15 rats. A rich collateral system developed rapidly from the transposed spleen to
      the systemic circulation. Angiography, performed four weeks after the ligation,
      revealed that almost all of the injected contrast medium was diverted into the
      systemic circulation via those newly developed collaterals. The described method
      as an experimental model could be of value in the search for a spleno-hepatic
      axis.

PMID- 1035369
TI  - [Cell mediated immunoresponsiveness in patients with bladder cancer: study using
      age matched control and multiple dose specific mitogens (author's transl)].

PMID- 1035370
TI  - [Studies on locality diagnosis of adrenal tumors: anatomical study on adrenal and
      juxta-adrenal veins in Japanese and its contribution to adrenal vein
      catheterization method (author's transl)].

PMID- 1035371
TI  - [Sizes of upper urinary tract calculi and methods to remove these calculi
      (author's transl)].

PMID- 1035372
TI  - [Hydrostatic pressure treatment for malignant lesions of the urinary bladder. 4th
      report. Analysis of the follow-up results (author's transl)].

PMID- 1035373
TI  - [Functional and morphologic studies on the renal pelvis and ureter in relation to
      surgical treatment for the congenital hydronephrosis (author's transl)].

PMID- 1035374
TI  - [A study on tumor of the bladder: clinical and prognostic studies on 426 cases
      (author's transl)].

PMID- 1035375
TI  - [Renal cell carcinoma. The clinical significance of its histopathological growth
      pattern and lymphocytic infiltration (author's transl)].

PMID- 1035376
TI  - [A study on mechanism renal hypertension caused by the movable kidney (author's
      transl)].

PMID- 1035377
TI  - Treatment of acute alcoholism.

PMID- 1035378
TI  - [Werlhof's disease].

PMID- 1035379
TI  - [Laser-treatment of the anterior segment of the eye with the new glaucoma
      research laser (author's transl)].
AB  - The possibilities for treatment of the anterior segment of the eye with the new
      glaucoma research laser, model 152, constructed by Britt-Corp. are reported on,
      along with the possibilities of vasodesolation, pupilplastics, iridontomies and
      iridectomies. Especially mentioned is the technic and possibility of laser
      trabeculopuncture. This laser archieves remarkable success also in open-angle
      glaucoma and closed-angle glaucoma provided the technic is suitable. It is shown
      that all operations can be carried out by an ambulant patients and practicly
      without any complications. There are no problems during the aftertreatment for
      the doctor or for the patient.

PMID- 1035380
TI  - A method for measuring footpad swelling in bats.

PMID- 1035381
TI  - [Congenital erythropoietic coproporphyria in 2 brothers].

PMID- 1035382
TI  - [Coccidioidomycosis in Mendoza].
AB  - 3 cases of cocidiomycosis observed in the province of Mendoza (Argentina) are
      described by the authors. The study of the endemic cocidiomycosis in Argentina
      and the ecological aspects of this disease in Mendoza are studied by the authors.

PMID- 1035383
TI  - [Idiopathic calcinosis of the skin].
AB  - Biochemical, radiologic and enzymatic studies are carried out in a case of
      idiopatic calcinosis cutis. The diagnosis has been obtained by exclusion of the
      other forms of calcinosis cutis. Therefore we believe that the disease may evolue
      in the future to a sistemic disease probably "collagen disease". However, today
      there is no evidence for this.

PMID- 1035384
TI  - [Herpetiforme pemphigus].
AB  - The case is presented of a woman, who for seven years had vesicobullous
      outbreaks, typical of Dermatitis herpetiformis, with an extraordinary itching.
      The first biopsy had a doub acantholysis but the following one showed:
      "eccematoid-like spongiosis with eosinophilia" and "subepidermal bulla with
      eosinophilia, erythema multiformislike". The evolution of the case was to
      pemphigus foliaceus, and by the action of long-standing corthicotherapy ended in
      a typical Senear-Usher with present good health. These anomalous cases, first
      described clinically by Brocq, and histologically by Unna et Leredde, are best
      known now as "Pemphigus herpetiformis" (Jablonska et al.).

PMID- 1035385
TI  - [Allergy to domestic animals].
AB  - This report concerns of 37 cases of allergenicity to domestic animals, dogs and
      cats. Clinical observations and skin tests confirm diagnosis showing dog and cat
      danders as etiologic factors. Sixteen cases were positive only to cat and dog
      danders and twenty one cases were associated with house dust, mould spores,
      feathers, etc. Bronchial asthma, rhinitis and contact dermatitis in face and lips
      were observed. Symptomatic treatment, elimination or avoidance when possible of
      contact with these animals and specific hyposensitization was carried out.
      Allergic symptomatology disappeared in twenty three cases, five abandoned
      treatment and in the others the allergic episodes showed less incidence and
      frequency. Shorter treatment time necessary for cases positive to dog and cat
      danders (a year to year and a half). In the others two or three years were
      required.

PMID- 1035386
TI  - [Carcinoid papillomatosis].
AB  - Papilomatosis Carcinoides, presents clinical and histological characteristics
      that may be authentically described as a transition state between the benign
      papillomatous proliferations and spindle cell carcinoma. It involves a series of
      clinical conditions, that are described with different names that correspond to
      the condyloma accuminatum gigantum. [Buschke and Lowenstein) wartic carcinoma
      [Ackerman], Papillomatosis oral florid [Rock and Fisher], carcinomatoid [Gilbert]
      profuse conjuntival papillomatosis [Bazex], etc. These latter only refer to
      partial localizations or a special clinical form. That is why we believe the
      denonmination Papillomatosis Carcinoides, is preferable, which is its cutaneous,
      mucose or semimucose forms involves all of them. The treatments applied to the 18
      cases presented have been very diverse: they vary from the elimination of the
      lesions by the application of topical podophylin to large surgical ablations. But
      most of them showed a regression or cure of their lesions by citostatics
      [methotrexate] not prevent the proliferative advance of the lessions. These
      therapeutic data can also contribute to its nosologic classification. In some
      cases they have an evolutive character with slow progression for years, still
      being curable with podophylin and in others that due to their chronic evolution
      with added supuration, and complications of the general health, make surgery
      necessary. In most cases, the antimetabolities are the therapy of choice the
      radiations seem inoperative. It may be noted that tumoral papillomatous lesions
      produced by virus, exist in veterinatian pathology (fibropapillomatosis in the
      bovine genitals, equine sarcoid, papilomatosis of goats, monkeys, etc.).
      Noteworthy are those of the oral mucosa of rabbits which are white greyish
      sesiles or pedunculated small nodules localized mostly on the inferior surface of
      tongue with a similar histology to the papilomatosis carcinoides. These
      observations would suggest a viral ethiology, even though all the efforts to
      isolate the virus of the lesions gave negative results. Our attention is drawn to
      case n. degrees 14. That began as a simple plantar wart. There have also been
      numerous cases in which from the beginning they were simple condylomas
      accuminatum, caused without any doubt by a virus. The carcinoid papillomatosis
      could be related to the spindle-cell carcinoma that developed in the areas of
      chronic infection with herpetic virus n. degrees 2, where the virus can be
      isolated from the lesions; the virus disappearing later with the development of
      the epithelial tumoral state [cases described previously by some authors as
      neophasias on vaccination scars and on recurrent genital herpes].

PMID- 1035387
TI  - [Persistent scabietic nodules with cutaneous lymphoplasia].
AB  - Two patients with one year duration post-scabious nodules are reported. Lymphoid
      hyperplasia was found histologically and a malignant lymphoma was suspected. Six
      patients with pseudolymphomatous scabious nodules were found in the literature
      and of these only one had evidence of lymphoid follicle formation with germinal
      centres. Short lived and persistent scabious nodules are discussed and diagnosis
      with lymphomatous nodules, dermatofibroma and urticaria pigmentosa considered. A
      "Darier's sign" was elicited on rubbing the lesions which is probably related to
      the increased number of mast cells in the infiltrate and may explain the
      persistent pruritus. Histological criteria to separate cutaneous lymphoplasia
      from lymphoma are reviewed and other more common causes of lymphadenosis benigna
      cutis are considered. Cutaneous lymphoplasia in persistent scabious nodules is
      possibly an indirect evidence of the importance of immunological factors in
      scabies.

PMID- 1035388
TI  - [Aspects of cutaneous sarcoidosis in Brazil].
AB  - This study collects all cases of sarcoidosis with cutaneous involvement referred
      to in the Brazilian literature. Only 40 cases could be found confirming the
      rarity of the disease in Brazil. With regard to these cases the following aspects
      of the disease were studied: age, incidence, race and sex distribution, origin of
      patients, clinical forms, systemic involvement, behaviour of the intradermic
      reactions and histopathology. Some characteristics could be established: 1)
      Females are most frequently affected than males. 2) No racial differences were
      noticed as far as the caucasian and the negroid are concerned. 3) The onset of
      the disease occurred between  16 and 69 years of age (mean age 37). 4) All
      patients originated from the south-central region of the country. 5) The most
      frequent cutaneous forms were associations of papulous lesions, nodular lesion
      and plaques. 6) Besides the skin, involvement of lymph nodes, bones, liver, eyes,
      spleen, salivary glands, heart, bowels and the facial nerve could be found.
      Heerfordt syndrome (uneoparotidic fever) was seen only once. Death occurred
      twice. 7) Kveim test was positive in all 11 cases in which it was done.
      Tuberculin and lepromin tests resulted in weak reaction or its complete absence.
      8) All cases were confirmed by histopathology. Eight of the forty biopsies were
      reexamined by the authors themselves.

PMID- 1035389
TI  - [Nonvenereal lymphangitis of the penis].
AB  - Two personal cases of Non venereal Lymphangitis of the Penis are presented in 23
      and 28 men, and 38 cases from the literature are reviewed. This benign self
      limiting condition is not too well known among dermatologists and urologists. The
      clinical changes, in particular noted by palpation are characteristic: painless
      firm cartilaginous cord freely movable behind the corona of glans penis in the
      coronary sulcus. The inguinal lymph nodes are not involved. The microscopic
      features in one of our patients demonstrated that the lesion results from cystic
      dilatation of secondary organization of the thrombus. The etiology is unknown. We
      favour the mecanical trauma as an important factor based on excessive sexual
      activity of the patients.

PMID- 1035390
TI  - [Granuloma gluteale infantum].
AB  - Bibliographic review of all the published cases of granuloma gluteale infantum
      and study of the second observation in Argentina. In this case there was a
      previous Leiner's erythrodermia treated with fluorinatec corticoid creams. The
      typical lesions appeared suddenly. The authors made a histopathologic study and a
      review of the pathogenetic theories on this dermatose. In the observation of
      authors the lesion disappeared in spite of persistence with the treatment with
      fluorinated corticoid creams, one of the causes of this dermatose according to
      some authors.

PMID- 1035391
TI  - [New drugs in the treatment of leprosy].
AB  - Two groups of patients were chosen for this treatment; the first group of 14
      patients was treated with a daily dose of 600 mg. of Rifampicine and the second
      group with Rifampicine associated with Isoprodian (1-2 tablets). In the first
      group clinical and bacteriological improvement was apparent. This was parallel in
      bacteriological and morphological index. Two patients became negative in nasal
      mucous. Tolerance was good and number of leprosy reactions 65%. In the second
      group clinical improvement was good in general but one case that presented a
      continuous polyneuritis and hepatic intolerance. Bacteriological results were
      lightly lower than the first group and the number of leprosy reactions 85%. This
      treatment is considered inferior to the sulfons, which is very expensive. A
      longer period of time will be needed to appriase results.

PMID- 1035392
TI  - [Study of the aerobic bacterial flora of onycolysis and paronychia caused by
      Candida].
AB  - The aerobic bacterial flora of 63 cases of onicolysis 78 of paronychis and 5 of
      onicomadesis produced by yeast-like fungus were studied. Bacterial isolation was
      carried out in nutrient agar with a concentration of 10 mug/ml of nystatin. These
      microorganisms were identified following the Otto Bier and Bailey & Scott's
      techniques (3, 1). Bacterial contamination was very frequent. One species or more
      were isolated from 93,6% of onicolysis and 97% of paronychis. The onicolysis
      presented the following flora: "Staphylococcus aureus" in 22 cases,
      "Staphylococcus epidermidis" in 21, Gram positive sporulated bacilli in 17,
      "Enterobacteriaceae" in 13, and "Pseudomona aeruginosa" in 6. The paronychial
      lesions showed the following flora: "Staphylococcus aureus" in 21 cases,
      "Staphylococcus epidermidis" in 26, Gram positive sporulated bacilli in 17,
      "Enterobacteriaceae" in 17 and "Pseudomona aeruginosa" in 3. It is important to
      emphasize that "Pseudomona aeruginosa" was isolated in a few cases of both types
      of candidal onixis, contrary to usual reports (2, 4, 9). No significant
      difference between the aerobic bacterial flora of the onicolysis and paronychia
      was found, that would give an explanation of the existence of these two clinical
      forms of candidal nails infection.

PMID- 1035393
TI  - [Bowen's disease].

PMID- 1035394
TI  - [Guatemalan cutaneous syndrome in actinic dermatitis].
AB  - The author, describes the Actinic Dermatitis and a syndrome that he named
      "Sindrome cutaneo guatemalense" SCG (Guatemala's Cutaneous syndrome). Its has
      been studied and found in 98;5% of more than a thousand patients studied since
      1957. He considered the SCG a patognomonic syndrome and of practical importance
      in the positive and differential clinical diagnosis of Actinic dermatitis with
      the other photodermatoses of the face, neck and "V" of the chest. The finding of
      the SCG, is of great help to the clinicians and dermatologits who practise in
      tropical countries.

PMID- 1035395
TI  - [Skin manifestations in patients with renal chronic renal failure on regular
      hemodyalysis].
AB  - The authors studied the skin disorders in 50 hemodialyzed patients. Pruritus
      appears to be the main dermatological feature by the frequency of its occurrence
      and by its unpleasant and even intolerable effects. This sign is more frequent
      among long time dialyzed patients and seems to be due to 2 factors: high urea
      blood concentration and secondary hyperparathyroidism. Calcinosis cutis is less
      frequent than pruritus. It seems to have the same origin and can be considered in
      the more general picture of the metastatic calcinosis in patients with renal
      failure and secondary hyperparathyroidism. Hypermelanosis, exceptional in the
      chronic renal insufficiency patients before hemodialysis, is present in 41% of
      our group. It is more obvious in the long time dialyzed patients. The nail
      disorders are mostly the absence of lunula (30%), related to the anaemia, and the
      half and half nail (36%) that seems specific of the severe azotaemia. Skin
      dryness (30%) and ichthyosis (10%) can be related to the pruritus. Alopecia, drug
      reactions and prurigo seems to have a particular indidence. Two patients
      presented bullous eruptions localized in sunlight exposed areas of skin. The
      clinical, histological and immunological aspect was identical to that observed in
      the Porphyria Cutanea Tarda but all the porphyrin levels in the urine and faeces
      were normal.

PMID- 1035396
TI  - [A case of Nonne-Milroy syndrome associated with chyloabdomen. Immunologic
      study].
AB  - A case of None Milroy syndrome with chiloabdomen in a 7 year old girl is
      reported. The most important features are the immunological alterations
      (depressed delayed immunity in the affected extremity and decreased level of
      IgA). A review of the literature is made.

PMID- 1035397
TI  - [Furunculoid myiasis caused by Dermatobia hominis].
AB  - The authors report a case of forunculoid miasis by "Dermatobia hominis" ("Ura"
      fly). a process that being not very common in the Argentine Republic is sometimes
      misjudged as a furunculosis. The patient reported, a white woman, 51, travelled
      to a zone where this parasitose is endemid. After some time of her stay there,
      she noted three small nodes in her vulvar region. They grew on until reaching
      nearly the size of a walnut. At her first consultation with a gynecologist it was
      taken as a case of furuncolosis and treated with antibiotics. As the treatment
      didn't prove succesful, she asked for dermatological advice. It was then possible
      to verify the presence of three nodes. In the central hole of one of them, there
      could be seen a whitish body that soon disappeared inwards. This lead to the
      diagnosis of forunculoid miasis. An accurate and easy-to-perform treatment was
      carried out: a 1% solution of formaldehyde in distilled water was infused through
      the central hole of each node. This determined the larva's caudal extremity to
      appear in search of air. It was taken advantage of this situation to remove the
      larvae with a pair of nippers. "Dermatobia hominis" is widely spread in the warm
      climated Argentine northern provinces of Chaco, Formosa and Misiones, as well as
      in Brazil, Paraguay and some regions of Uruguay. It is also known under the name
      of "Ura". It is a large fly, yellow faced, with dark-blue thorax; an almost
      rombic metallic-blue abdomen, orange antennae and legs, and dark-brown wings. It
      lives on the nutrients spared during its larval stage and both fecundation and
      oviposition, take place along its week-long life. The fecundated female catches
      different haematophagus insects on the wing, sticking sets of eggs to their
      abdomens. An embryo developes in each egg, being ready to emerge in a week but
      does this only when the bearer insect settles on a homeothermal being piercing
      and penetrating the skin of the new guest in about 10 minutes.

PMID- 1035398
TI  - [Inflammatory verrucous epidermal nevus (IVEN)].
AB  - From the original description of Altman and Mehregan (1971) a new clinical type
      of linear nevus is known as inflammatory linear verrucous epidermal nevus
      (ILVEN). Two girls of 5 and 4 years of age are reported. One of them had good
      therapeutical results with the use of trichloroacetic acid. The clinical and
      histopathological aspects of this nevus are reviewed and the differential
      diagnosis should be done with: lichen planus, lichen striatus, linear psoriasis,
      zoniform dermatitis, naevus unius lateris.

PMID- 1035399
TI  - [Post-traumatic achromia in vitiligo (vitiligo facticio)].
AB  - Two patients affected with vitiligo showed achromic lesions in areas of skin
      apparently normal submitted to the action of external traumatic agents. In the
      first case the striate linear lesion might be attributed to the excoriation due
      to pruritus determined by scabies. In the second one an angular lesion in both
      feet was strictly limited to the areas exposed to the straps of sandals.

PMID- 1035400
TI  - [Nail-patella-elbow syndrome].
AB  - The authors describe a typical, non familiar case of nail-patela-elbow syndrome,
      in which was found malformation of the nails and bones involving mainly the Knees
      and elbows, together with spondylolisthesis of the spine at the level L5-S1.
      There were no renal, ocular or psychic alterations.

PMID- 1035401
TI  - [Chronic urticaria. Provocation test].
AB  - Sixty patients of ages ranging from 11 to 64, with chronic urticaria from 2
      months to 50 years duration, were studied with the provocation test. We found
      responses in 33.3% of patients. Tartrazine was the most common inducer, specially
      in those patients sensitive to aspirin with increased salicilate blood levels. As
      we did not use aspirin as inducer the results with tartrazine are more relevant
      and can be used to detect a positive response to aspirin. The relation between
      tartrazine and aspirin was not observed in patients with pressure or cholinergic
      urticaria. The provocation test is most useful in patients with chronic urticaria
      of unknown cause. 4 hydroxybenzoic acid and sodium acid and sodium benzoate were
      the more common inducers in the latter patients. We feel that the provocation
      test is a useful tool to study patients with chronic urticaria. Tartrazine, 4
      hydroxybenzoic acid, sodium benzoate, tiramin and penicilin are included in the
      test. The responders should eliminate the offender from their diet.

PMID- 1035402
TI  - [Halcinonide-neomycin-nystatin in the treatment of dermatosis and cutaneous
      candidiasis].
AB  - Sixty-four patients were treated for inflammatory dermatoses or cutaneous
      candidiasis with a new corticosteroid combination drug, halcinonide-neomycin
      nystatin (HNN). In 50 patients treated for psoriasis, atopic dermatitis,
      eczematous dermatitis, or neurodermatitis, HNN was evaluated in a double-blind,
      paired comparison study with hydrocortisone (HC) as the control drug. HNN was
      superior in 24 patients, HC was superior in 6, and the responses were equal in
      18. The overall therapeutic response was Excellent with HNN in 29 patients as
      compared to 14 with HC. The anticandidal properties of HNN were assessed in a
      parallel study with iodochlorhydroxyquin-hydrocortisone (I-HC) as the control
      drug. The most frequently treated conditions were "erosio interdigitalis
      blastomycotica" and candidal lesions of the neck region. The response with HNN
      was Excellent in 7 of 14 patients as compared to 4 out of 14 treated with I-HC.

PMID- 1035403
TI  - Occurrence of amatoxins in Amanita ocreata.

PMID- 1035404
TI  - Woman dancing dreaming: Psychosocial benefits of the aboriginal outstation
      movement.
AB  - The establishment of an Aboriginal outstation, or small autonomous community, is
      described. Some of the beneficial psychosocial changes observed during an
      eighteen-month period are described, and some possible reasons for them outlined.
      The outstation movement is presented as a viable, Aboriginal-initiated solution
      to some of the dilemmas facing present-day Australian Aborigines.

PMID- 1035405
TI  - An unusual stingray injury--the skindiver at risk.
AB  - Serious abdominal injury following a stingray attack on a skindiver is described.
      Knowledge of the creature's habits and the avoidance of swimming along the seabed
      are recommended as precautionary measures against such an injury.

PMID- 1035406
TI  - The preterm baby.

PMID- 1035407
TI  - Entrainment of the adrenal rhythm to photoperiod prior to puberty: effects of
      early experience on the adrenal rhythm and puberty.
AB  - The purpose of this study was to determine whether exposure to a cycle of light
      and dark before the onset of the adrenal rhythm would be necessary in order for
      rats to develop a normal rhythm of peripheral corticosterone when placed in a
      test photoperiod at weaning age. Rats were reared in constant light (LL) until
      weaning age, at which time they were placed in a cycle of 14 h light, 10 h dark
      (14:10). Females born and reared in 14:10 had peak corticosterone values at 14.00
      h on days 22 and 26, and at 18.00 h on days 32 and 36. Males did not display a
      clear-cut rhythm at 22 or 26 days but had peak corticosterone at 18.00 h on days
      32 and 36. Males and females reared in LL until weaning had no rhythm as a group
      in 14:10 at 24 days of age, but had a corticosterone peak at 18.00 h on days 28
      and 40. Females born and reared in LL and exposed to 14:10 for 1 day developed an
      adrenal rhythm regardless of the age at exposure, but only 25 day old animals
      showed a normal pattern for their age group. Puberty was advanced in rats exposed
      to a single day of 14:10 at 25 days of age, but was delayed in younger rats (22
      days old), and was unaffected by light exposure in older rats (28 days of age).
      It can be concluded that early exposure to light-dark cycles is not required for
      the normal development of an adrenal rhythm in the weanling rat, and that the
      setting of the corticosterone rhythm to the photoperiod can occur quite rapidly.
      Rats at 25-26 days of age are able to respond differently to a light cycle
      challenge than younger rats. A photoperiodic stimulus at that time can advance
      the onset of puberty.

PMID- 1035408
TI  - Modifications of the striatal dopamine metabolism during the estrus cycle in
      mice.
AB  - The metabolism of striatum dopamine (DA) was studied in mice during proestrus,
      estrus and diestrus. The following results have been obtained: (1) the
      concentration of DA is higher in diestrus than in proestrus and estrus; (2) the
      concentration of its metabolite, homovanillic acid (HVA), is maximum in the
      estrus phase; (3) the DA turnover, evaluated by measuring the DA disappearance
      after blocking synthesis with methyltyrosine, is faster in estrus than in the
      other phases. These results have been discussed in view of the possible role of
      dopaminergic mechanisms in the control of gonadotropin secretion.

PMID- 1035409
TI  - [Liver disease caused by halothane. Considerations on some clinical cases of
      halothane-induced jaundice].

PMID- 1035410
TI  - [Microbial maps and blood cultures in acute leukemia].
AB  - Microbial maps were performed taking swabs from nose, pharinx, external auditory
      meatus, groin, vagina, sputum and urine cultures in 69 cases of acute leukaemia,
      in order: to assess the germs' incidence in an "open ward" department; to
      eliminate the most dangerous pathogens with local treatment or with a selective
      therapy without broad-specturm antibiotics; to check, in the 43 cases followed
      from onset, the changes occurring during the admission and the disease
      progression; to collect data for comparison with a "sterile" ward. The local
      decontamination had only a temporary effect. During the course of the disease
      new, particularly dangerous, pathogens were cultured. Blood cultures were
      positive in 15% of the patients with fever at the onset of the disease, and in
      36.9% of the patients with fever during the disease progression. These values
      were virtually the same as those observed in the acute stage of C.M.L. (35.7%).
      In akute leukaemia E. coli (35%) was the most common, followed by P. aeruginosa
      (20%), Klebsiella (15%), S. alpha haemolyticus (10%) and others. There was little
      or no relationship between the germs in the maps and those in the blood cultures,
      though it must be remembered that no stool cultures were examined.

PMID- 1035411
TI  - [Therapeutic action of a combination of functioning mammary gland extract and
      methyltestosterone].

PMID- 1035412
TI  - [Methotrexate in the therapy of chorioepithelioma].

PMID- 1035413
TI  - [Isolated galactorrhea. Pathogenetic interpretation and nosological
      classification of a clinical case].

PMID- 1035414
TI  - Reversible deafness as model of pressure damage to the VIIIth nerve.
AB  - Frequency-specific compound action potentials (CAP) of the VIIIth nerve were
      registered in patients in which surgery confirmed retrocochlear pathology. A
      different pathologic behaviour of threshold latency was encountered for 2 and 4
      kHz CAP, respectively. This was due to the question of whether transmission of
      neural information by the acoustic nerve's fibres was blocked completely by
      retrocochlear pathology or not. A totally reversible hearing loss in a case of
      cystic arachnitis can offer a reasonable explanation.

PMID- 1035415
TI  - Experimental labyrinthine lesions through stylomastoid foramen.
AB  - It was confirmed that the substances injected into the facial nerve through the
      stylomastoid foramen, reached every part of the inner ear. In sensitized animals,
      by repeated provocative injections of antigen, acute reversible episodes, very
      similar to that of Meniere's disease, were observed. The injection of various
      solutions and the provocative injection into the sensitized animals, resulted in
      completely opposite reactions. In sensitized animals, the electrophysiological
      phenomena of the cochlea also showed fluctuations like Meniere's disease.

PMID- 1035416
TI  - Solitary schwannoma of the cervical vagus nerve.
AB  - A case of benign, solitary schwannoma of the cervical vagus nerve with
      ipsilateral vocal cord paralysis is presented. The differential diagnostic
      aspects are discussed, with special reference to neurologic deficit in
      association with this lesion. The possible occurrence of concomitant unrelated
      malignancy is emphasised.

PMID- 1035417
TI  - Rhinoscleroma: a scanning electron-microscopic study.
AB  - Nasal biopsies from 6 patients with rhinoscleroma were studied by scanning
      electron microscopy. Numerous bacilli of different sizes were found on the
      epithelial surface. Few bacilli with thin spiral terminal cilia were seen over
      the surface of large protruding non-epithelial cells. These cells appeared to be
      the Mikulicz cells migrating from the tunica propria to the epithelial surface
      through small ulcerations. In the tunica propria, Mikulicz cells containing
      numerous bacilli were observed. In 4 patients, round bodies and long tubular
      structures were found on the epithelial surface. These bodies were suggested to
      be fungi, yet their exact nature and their relation to Klebsiella
      rhinoscleromatitis bacilli need further investigation.

PMID- 1035418
TI  - [Changes in the composition of leukocytes of carp after infection with
      Dactylogyrus extensus (Monogenoidea, Dactylogyridae) in the light of a new
      classification of formed elements].
AB  - The paper presents new data on the effect of Dactylogyrus extensus on the blood
      of the carp. The data have become available due to a new classification of formed
      elements worked out by N.T. Ivanova. One of characteristic features of
      dactylogyrosis is eosinophilia. Polychromatophil anaemia and anisocytosis were
      recorded as well.

PMID- 1035419
TI  - [Demonstration on the frog tongue of the changes of vascular permeability under
      the effect of the mediators of inflammation].

PMID- 1035420
TI  - [Characteristics of cardiac glycoside treatment of circulatory insufficiency in
      young children with acute pneumonia].

PMID- 1035421
TI  - [Diurnal rhythm of excretion of free amino acids in young children with
      intestinal toxicoses].

PMID- 1035422
TI  - Dietary salt and round heart disease in turkey poults with a note on the minimum
      level of supplementary salt necessary in corn-soybean diets.
AB  - Round heart disease in turkey poults has been associated with high levels of
      dietary salt and when it occurs in the field recommendations often include a
      reduction in the level of dietary salt. Poults fed diets containing up to 1.5%
      salt and 1.5% sodium did not exhibit signs of round heart disease. A high
      mortality rate occurred with poults fed a salt-free diet. Post-mortem analysis
      generally revealed enlargement of the kidneys with urates; exudate was present in
      both abdominal and thoracic air sacs. Growth trials indicated that in order to
      maintain an optimum feed:body weight gain ratio, corn-soybean diets should
      contain at least 0.1--0.2% supplemental salt, and at least 0.2--0.3% salt when
      growth rate is considered. Minimum salt levels could not be reduced further by
      adjustment of the total dietary sodium:chloride ratio to unity.

PMID- 1035423
TI  - [State of the sympathetic-adrenal system in newborn infants (clinico-biochemical
      comparisons)].
AB  - A study was made of urinary catecholamine excretion in 102 newborn boys on the
      1st-8th day after birth. Depending on the state at birth neonates were divided
      into 2 groups: the 1st group included babies born in satisfactory condition (60),
      and the 2nd group - at the state of mild asphyxia. Catecholamines were determined
      on the 1st-2nd, 3rd-5th, and 6th-8th days after birth. It was shown that at the
      time of birth the noradrenaline level prevailed over the adrenaline level, but as
      soon as the 3rd-5th day the noradrenaline content displayed a relative reduction
      in both groups. Asphyxia showed practically no influence on the urinary
      adrenaline and noradrenaline excretion of the newborn boys; however, there were
      significant differences in the dynamics of dophamine excretion with the urine.
      The children born asphyxiated urinary excretion of dophamine showed a continuous
      accretion.

PMID- 1035424
TI  - Social implications for the rehabilitated patient.

PMID- 1035425
TI  - [Indications, contraindications and legal problems in antiandrogen treatment].
AB  - The author in his present paper gives an outline of the indications,
      contraindications, and legal problems of Androcur treatment. Androcur
      (cyproterone acetate) is an antiandrogen that is capable of competitively
      inhibiting androgens in the organism. Accordingly, the effects obtained by drug
      therapy, of which the purpose is to reduce the sexual desire or libido, are
      similar to those produced by operative castration. The use of such drugs makes it
      possible to control abnormal sex drives and desires and prevent sexual offenders
      from becoming recidivous. Since treatment with Androcur is an intervention in the
      deeply personal sphere and there is not yet availability any reliable data on the
      full reversibility of the phenomena involved (for example, alterations to the
      testicles) especially in the case of long-time treatment, such therapy should be
      carried out on the principle of absolute voluntariness and after suitable
      suggestions have been furnished as to the proper treatment of the respective
      subject.

PMID- 1035426
TI  - Monozygotic twins discordant for schizophrenia: a review.

PMID- 1035427
TI  - The microbiology of the red meat carcass and the slaughterhouse.

PMID- 1035428
TI  - Molecular weight distribution of RNA fractionated on aqueous and 70% formamide
      surose gradients.

PMID- 1035429
TI  - Translational control in embryonic muscle.

PMID- 1035430
TI  - [Storage of lyophilized anti-pleuropneumonia vaccine, strain KH3J Sr+].

PMID- 1035431
TI  - [Preliminary attempt at the release of male sterile Glossina palpalis gambiensis
      (Upper Volta)].

PMID- 1035432
TI  - [Paroxysmal EEG and EMG discharges induced by intermittent photic stimulation in
      the photosensitive Papio papio].

PMID- 1035433
TI  - [Toxoplasmosis and cats].

PMID- 1035434
TI  - [Various aspects of the biology of Lymnaea columella Say, 1817 (Gastropoda,
      Pulmonata)].

PMID- 1035435
TI  - Unusual masses in the spermatic cord: report of six cases and review of the
      literature.
AB  - Differential diagnosis of spermatic cord swellings includes direct inguinal
      hernia, hydrocele, spermatocele, hematocele, lipoma, tuberculosis, and
      filariasis. This communication focuses attention on other unusual swellings of
      the spermatic cord. Three cases of sarcoma, two cases of foreign body in the
      spermatic cord, and one case of vasitis are presented. Although unusual, these
      conditions should be considered in the differential diagnosis of spermatic cord
      swellings.

PMID- 1035436
TI  - Isolated galactorrhea with normal serum prolactin levels: clinical implications.
AB  - Detailed endocrine-metabolic studies were performed on five women who were
      otherwise well but who had had inappropriate breast secretions for variable
      periods of time (three months to 16 years). Our results suggest that the presence
      of a lactose-containing breast secretion, which strictly defines galactorrhea,
      does not necessarily indicate a recognizable abnormality if normal hypothalamic
      pituitary function is present. In these regularly menstruating women with
      isolated galactorrhea, we suggest a minimum initial evaluation, but careful long
      term follow-up studies to identify those cases which may progress to the other
      recognized, more serious amenorrhea-galactorrhea syndromes.

PMID- 1035437
TI  - Brain abscess caused by Cladosporium trichoides (Bantianum): a case with
      paranasal sinus involvement.
AB  - Dematiacious fungi (ie, fungi with dark hyphae) are a rare and usually fatal
      cause of central nervous system infection. Cladosporium trichoides has been
      implicated most frequently. Documentation of extra-CNS involvement has been rare.
      Our patient had a brain abscess and paranasal sinus infection due to C
      trichoides. The organism was sensitive to less than or equal 2mug/ml of
      flucytosine. Although our patient did not receive flucytosine, it is possible
      that this drug, because of its excellent penetration into the cerebrospinal
      fluid, may be a useful therapeutic agent in cerebral cladosporiosis.

PMID- 1035438
TI  - [Method of recording and study of functional changes in serial
      hysterosalpingography].

PMID- 1035439
TI  - Social work information and accountability systems in a hospital setting.
AB  - Information and accountability systems for departments of social work are a major
      concern for the profession, particularly within the health care sector. This
      paper describes the development of such a system within a large university
      hospital, the forces that led to its development, and the multiple expectations
      for its usefulness in planning and implementing social work services most
      effectively, within the lowest cost. It includes potential for building research
      projects and is utilized as a communication mechanism for recording.
      Collaboration within the profession is essential for implementing objective
      standards to be utilized in reviewing delivery of professional social work
      services.

PMID- 1035440
TI  - The urethral pressure profile: an aid in evaluation and management of urinary
      incontinence in children.

PMID- 1035441
TI  - The evaluation and treatment of superior oblique muscle palsy.

PMID- 1035442
TI  - Nd:Yag laser.

PMID- 1035443
TI  - The use of CO2 laser in otolaryngology: a progress report.
AB  - Since 1971 the CO2 laser has been used in otolaryngology at Boston University
      School of Medicine, University of Illinois, and the Eye, Ear, Nose, and Throat
      Hospital, New Orleans; over 560 patients have been cared for and over 1,000
      operations performed. The instruments have proved to be reliable and the use of
      CO2 laser relatively free of complications when appropriate precautions are
      taken. The nature of the laser wound is such that laser surgery has facilitated
      the management of numerous benign and malignant lesions of the larynx as well as
      the oral cavity, pharynx, and tracheobronchial tree. Laser surgery is associated
      with a minimal morbidity, excellent healing, minimal scar formation, and
      excellent residual function. The instrument has been most useful in the
      management of lesions situated in relatively inaccessible areas such as the
      nasopharynx, subglottic area of the larynx, and tracheobronchial tree. The
      advantages of laser surgery in otolaryngology are so significant that it can be
      recommended for continued usage. Many applications of this unique surgical
      instrument have been identified but others need to be explored in the future.

PMID- 1035444
TI  - Targeted mass treatment: a new approach to the control of schistosomiasis.

PMID- 1035445
TI  - [Case of a high degree of similarity of the functions of the eye and body systems
      in monozygotic twins].

PMID- 1035446
TI  - [Study of the effect of various drugs on the motor activity of ciliated
      epithelium under experimental conditions].

PMID- 1035447
TI  - [Enzyme activities in the blood serum and individual organs in acute
      cholecystitis].

PMID- 1035448
TI  - Evaluation of the epidemic potential of western equine encephalitis virus in the
      northeastern United States.
AB  - The problem of evaluating the epidemic potential of western equine encephalitis
      in the northeastern United States is presented and possible reasons are discussed
      for the present lack of human and horse cases of this disease even though
      increased numbers of isolations of the virus have been obtained in the East
      during recent years. Epidemiologic factors of vector bionomics and virus strain
      variations are considered. It is concluded that while this virus strain can no
      longer be regarded as uncommon in the Northeast, the evidence indicates there is
      little potential for epidemic expression of this agent in the human and horse
      population. This appears to be due to differences in the bionomics of the
      mosquito Culiseta melanura, which serves as the primary enzootic vector in the
      northeastern United States and in the bionomics of Culex tarsalis that is the
      vector in the western region of the United States. Other limiting factors in the
      epidemic potential may be variations between virus strains located in the East
      and West.

PMID- 1035449
TI  - [Precipitation reaction and hemagglutination-hemolysis reaction in tuberculosis.
      I. Precipitation reaction (author's transl)].
AB  - Sera of patients, blood donors and cattle sera were examined by means of
      diffusion--in--gel technique using self produced antigens, prepared from H 37 Ra,
      one fresh isolated strain of M. tbc and BCG Jena. 38.2% of 421 patients with
      pulmonary tuberculosis reacted positive. Positive reactions were observed in
      55.7% of 199 patients suffering from another infectious disease and in 31;7% of
      normal sera. Most precipitation lines were found with the antigen prepared from
      H37 Ra after incubation for 7 months. In human sera as well as in cattle a
      dependence of reactions upon mode of antigen production was evident.

PMID- 1035450
TI  - [Precipitation reaction and hemagglutination-hemolysis reaction in tuberculosis.
      II. Hemagglutination-hemolysis reaction by Middlebrook-Dubos (author's transl)].
AB  - Sera of patients with pulmonary and extrapulmonary tuberculosis, of blood donors
      and cattle sera were researched in hemagglutination reaction, using untreated and
      papain-treated sheep erythrocytes, and in hemolysis reaction. 58% of patients
      with pulmonary tuberculosis and 23% of normal sera, reacted positive in at least
      one of the 3 reactions. 24 sera of 44 patients with extrapulmonary tuberculosis
      were found to be positive. The titer is important for diagnosis. In normal sera
      the highest titers were 1:64 in all reactions. Titers of 1:128 are to be
      considered as proof of tuberculosis. Considering the height of titers the
      hemagglutination-hemolysis reaction can also be used for diagnosis of
      tuberculosis in cattle.

PMID- 1035451
TI  - [Use and importance of cytology for tumor diagnosis in internal medicine].
AB  - Many fields of internal medicine give the assumption for the ingenious
      application of cytodiagnostics. The respiratory tract, the gastrointestinal
      system and the urinary passage are the most important groups of organs. A
      technically unobjectionable gaining of material is the basis for this. The
      examination of exfoliated cells and the fine needle aspiration biopsy are the
      technical variants. The close cooperation of a morphologically interested
      clinician with a clinically interested morphologist and the guaranty of the
      mutual control of cytology and histology yield a promising success method for the
      clinical differential diagnostics and for the early recognition of cancer.

PMID- 1035452
TI  - [Insulin lipoatrophy and its elimination through the use of monocomponent
      insulin].
AB  - Since their first description 50 years ago severe forms of lipoatrophy appearing
      above all in girls and women are occasionally a cosmetically significant and
      therapeutically problematic side effect of the insulin treatment of diabetes
      mellitus. On two own female patients is shown, how the hitherto recommended
      measures failed in distinctive cases and only the treatment with monocomponent
      insulin of the pig led to the restoration of the fatty tissue. The successful
      therapy of lipoatrophy with monocomponent insulin in all cases hitherto published
      confirms the hypothesis that a local antigen-antibody-reaction to highly
      molecular constituents of the commercial mixed insulins causes the atrophy of
      fatty tissue.

PMID- 1035453
TI  - [Morphometric studies of the density and diameter of capillaries in supraoptic
      and paraventricular nuclei of unmilked and milked cows].
AB  - With mathematical-statistical methods the density and the diameter of the
      capillaries of the NSO and NPV were investigated by unmilked and milked cows.
      After the milking the diameter of the capillaries is significantly expanded in
      both nuclei districts. The density of the capillaries measured through the length
      of the capillaries pro mm3 tissue, were not significantly enlarged after the
      milking stimulus. The adaptation on the changed functionstate of the
      neurosecreoty cells arrive at a maximum 15 min after the milking, to go back
      afterwards, by 60 min after the milking studied cows, to the values of the
      beginning. It is discussed, that the intensified blood maintenance of the
      activated neurosecretory cells of the NSO and NPV is of a higher oxygen
      consumption.

PMID- 1035454
TI  - The effect of lead on cells cultivated in vitro. II. Chronic exposure and
      development of resistance.
AB  - In a previous communication the acute effects of anorganic lead salts on L-A
      mouse fibroblasts cells cultured in vitro have been described. This report
      presents the results of long-term tests with L-A cells. Under continuous exposure
      lead tolerance developed, even to concentrations exceeding the LD50. The kinetics
      of the acquirement of resistance are demonstrated. The resistant cells adjusted
      more quickly to higher doses of the heavy metal than the controls. Low-resistance
      strains retained the growth characteristics of the parent cells, but with
      increasing levels of lead tolerance multiplication rates decreased significantly.
      After approximately 60 generations in lead-free environment the cells had to a
      major degree lost their resistance indicating that the induced lead tolerance is
      caused by adaptation rather than by mutation and selection. Lead resistance
      appears not to depend on lead exclusion, for the lead content of resistant cells
      and lead-exposed controls was found to be of a comparable order of magnitude.

PMID- 1035455
TI  - [Seasonal changes in the activity of the thyroid gland of the gerbil Meriones
      unguiculatus].
AB  - Positive correlation was observed between the thermostability level of the
      parental sperm and that of muscles in the progeny of the frog R. temporaria. The
      data obtained indicate that in animal evolution the thermostability of cells may
      be monitored by non-thermal factor or factors.

PMID- 1035456
TI  - [Influence of homologous n-alkanoic on functional properties of isolated skeletal
      muscles. II. Membrane resting potential and the osmotic effectiveness of alkanoic
      acid].
AB  - The influence of butyric, hexanoic, octanoic, and decanoic acid on the membrane
      resting potential of isolated frog skeletal muscles were studied and the osmotic
      effects of n-alkanoic acids tested. 1. n-alkanoic acids cause osmotic effects
      like impermeable non-electrolytes (sucrose). Therefore, the permeability to
      alkanoic acids of the resting muscle cell membrane seems to be small. There are
      no differences between the acids tested. 2. The membrane resting potential is
      differently affected. Butyric acid in high concentration effects a
      hyperpolarization of the membrane whereas higher homologues (C6--C10) cause a
      depolarization. The depolarizing action increases with increasing concentration,
      exposure, and with the length of the hydrocarbon chain of the alkanoic acids. 3.
      It is suggested that osmotic effects are the cause for hyperpolarization of the
      membrane by high concentrations of butyric acid. 4. The depolarizing action of
      hexanoic, octanoic, and decanoic acid is discussed with regard to alterations
      induced by alkanoic acids in the membrane permeability and/or in the metabolism
      of the cells.

PMID- 1035457
TI  - On the significance of nipple discharge in the diagnosis of breast disease.
AB  - Nipple discharge, especially the blood-stained type, is regarded as an important
      symptom in breast disease. In many reports the high incidence of malignancy is
      stressed and an active surgical approach has often been recommended. In this
      series of 80 women with nipple discharge the type of secretion and the result of
      exfoliative cytology were evaluated. Three women had cancer but the nipple
      discharge was important for the diagnosis in only one case. Six women had
      papilloma and in all the nipple discharge was essential for the diagnosis.
      Fibroadenosis and duct ectasia were the most common diagnoses. The blood-stained
      secretion was due to fibroadenosis in about half of the cases. No cancer was
      found in 46 women with a serous secretion. When a tumour is present nipple
      discharge is of little importance for the diagnosis and treatment. In the absence
      of a tumour and when exfoliative cytology gives no suspicion of cancer and no
      atypical cells or papillomatous clusters are present, an expectant attitude
      towards surgery seems satisfactory. With such an approach many surgical biopsies
      prove unnecessary, but a prerequisite is an organized follow-up.

PMID- 1035458
TI  - Breast cancer in identical twins. A case report.

PMID- 1035459
TI  - Treatment of Paget's disease of bone with salmon calcitonin.

PMID- 1035460
TI  - Studies on the effects of repetition of insufficient activation with butyric acid
      and benzimidazole in the sea urchin egg.

PMID- 1035461
TI  - Interaction of methylpredonisolone with adrenergic bronchodilators in isolated
      guinea pig tracheal strips.

PMID- 1035462
TI  - [Experimental studies on methylmercury intoxication, with special reference to
      the effects of electric stimulation].

PMID- 1035463
TI  - [Estriol levels in pregnancy toxemia, its sequala and postnatal development of
      the infants].

PMID- 1035464
TI  - [Selective angiography of the abdominal organs, with special reference to
      pancreatic diseases].

PMID- 1035465
TI  - [Experimental studies on the effect of electric stimulation on tissue metabolism
      of various organs].

PMID- 1035466
TI  - [Effects of various crude drugs on blood coagulation].

PMID- 1035467
TI  - [Experimental studies on methylmercuric chloride intoxication and detoxication].

PMID- 1035468
TI  - [Experimental studies on the influence of fluorine on tissue respiration].

PMID- 1035469
TI  - [Indiction for exchange transfusion based on the analysis of kernicterogenic
      factors].

PMID- 1035470
TI  - [Clinical studies of solid ovarian neoplasms, with special reference to embryonal
      carcinoma].

PMID- 1035471
TI  - The influence of propanediol-1,3 on the development of the legs, wings and lower
      beak of the chick embryo.
AB  - In seven series of 31-34 chick embryos each, the influence of the position of the
      egg during incubation and of the administration of 0.05 ml propanediol-1,3 on the
      5th day of incubation on the development and growth of the limbs and beak were
      studied. Isotonic saline injected embryos served as controls. The embryos were
      sacrificed at the age of 15 days. Incubation of the egg in a vertical position,
      with the air chamber pointing upward, proved to result in a slight, through
      significant reduction in the length of the limbs and beak. Propanediol was highly
      toxic if injected in the immediate vicinity of the embryo. If injected at some
      distance from the embryo, either into the air chamber or into the yolk, the agent
      proved to be teratogenic: measurements showed a considerable retardation of the
      longitudinal growth of the limbs and beak, the latter being a parrot beak in 60
      per cent of the cases, whereas both the tibia and the metatarsals were, moreover,
      bent posteriorward. Histological studies of the tibia showed an underdevelopment
      of the periosteal bone collar and, at the angle of the bone, a replacement of the
      posterior part of this collar by endochondral bone trabeculae. The abnormalities
      observed are dissimilar to those demonstrated in hereditary congenital
      chondrodystrophy and in micromelic conditions induced by insulin or sulfonamides.

PMID- 1035472
TI  - [Tight and gap junctions of the human ciliary epithelium as revealed by freeze
      fracture method (author's transl)].

PMID- 1035473
TI  - [Dark adaptation curves of albino rabbits studied by double-flash ERGs (author's
      transl)].

PMID- 1035474
TI  - [Ultrastructural changes of skin in Vogt-Koyanagi-Harada Syndrome (author's
      transl)].

PMID- 1035475
TI  - [Enhancement of the c-wave and abolition of the b-wave by intravenous injection
      of hypertonic solution (author's transl)].

PMID- 1035476
TI  - [Photocoagulation therapy of diabetic macular edema (author's transl)].

PMID- 1035477
TI  - [Studies on normal developing process of the retinal vessels and effect of oxygen
      on the developing retinal vessels of the young rabbit (author's transl)].

PMID- 1035478
TI  - [On the electron microscopic investigations of the Bruch's menbrane and
      choriocapillaries in human diabetes mellitus (author's transl)].

PMID- 1035479
TI  - [National registration of retinoblastoma children in 1975 (author's transl)].

PMID- 1035480
TI  - [A study on vascular changes of the retina by trypsin digestion method,
      especially in reference to the mechanism of microaneurysmal formation (author's
      transl)].

PMID- 1035481
TI  - [Clinical study on the resting state of accommodation. Report 1: The
      physiological change of the resting state of accommodation on the normal eyes
      (author's transl)].

PMID- 1035482
TI  - [Intraocular penetration and clinical evaluation of pipemidic acid in Pseudomonas
      keratitis (author's transl)].

PMID- 1035483
TI  - [Voiding uretrocystography. Complement of intravenous perfusion urography].

PMID- 1035484
TI  - [Effect of kanamycin, fucidin and tetracycline antibiotics on the chromosomal
      apparatus of human embryonic fibroblasts in tissue culture].

PMID- 1035485
TI  - The fine structure of the epithelium of prostate glands in adult female mastomys
      erythroleucus Temm.
AB  - The prostate glands in adult female Mastomys were studied with the light and the
      electron microscope. In the light microscopy, each prostatic acinus is lined by a
      single layer of tall cuboidal secretory epithelial cells which are surrounded by
      a capsule composed of a few layers of elongated and flattened cells. The acinar
      secretory epithelial cells show no presence of the supranuclear light areas in
      their cytoplasm and tend to be more readily stained with toluidine blue in the
      perinuclear and the upper basal cytoplasm than in the rest cytoplasm. In the
      electron microscopy, sharply localized pittings are occasionally found on the
      luminal surface and further the secretory granules which are closely situated to
      the apical cell surface are recognized. In the supranuclear cytoplasm, several
      well-developed Golgi apparatuses appear individually and early developing
      secretory granules are also observed. In the perinuclear and the upper basal
      cytoplasm the rough endoplasmic reticulum is well developed while in the lower
      basal cytoplasm the smooth endoplasmic reticulum is conspicuously developed and
      predominates.

PMID- 1035486
TI  - [Mitral insufficiency and obstructive cardiomyopathy, indications for mitral
      valve replacement].

PMID- 1035487
TI  - [Effect of aflatoxin B1, of some of its metabolites and of culture extracts from
      "Aspergillus parasiticus" on virulent bacteriophages (author's transl)].
AB  - Aflatoxin B1 has different effects on bacteriophages: it inhibits some virulent
      strains and induces lysogenic bacteria. In this experiments we have used several
      classes of phages of enterobacteria, streptococci, staphylococci and Bacillus. We
      have tested different substances: cristallized aflatoxin B1, metabolites of the
      same mycotoxin and culture extracts from a toxinogenic strain of Aspergillus
      parasiticus. The inhibitory effects observed are different for each strain, and
      for a given phage the substances do not show the same action.

PMID- 1035488
TI  - [Embryotoxicity and the immunodepressive action of tetracycline and its epi- and
      anhydro- derivatives].
AB  - The toxic effect of tetracycline and its epi- and anhydro-derivatives on growing
      chick embryos and the spleen cells of immunized mice was studied. High acute
      toxicity of 4-epianhydrotetracycline with respect to the chick embryos was found.
      Its LD50 was 4.8 times lower than toxicity of tetracycline hydrochloride. The
      characteristics of the acute toxicity was confirmed by the data on the embryo
      survival by the time of hatching. The same survival rate, i. e. 12 per cent was
      observed with the use of tetracycline and 4-epianhydrotetracycline in doses of
      1000 and 100gamma per embryo respectively. Comparative investigation of the
      effect of tetracycline and anhydrotetracycline on the spleen cells revealed high
      toxicity of anhydrotetracycline which induced the same decrease in the number of
      the antibody-producing cells as tetracycline when used in doses 40 to 100 times
      lower than those of tetracycline. High toxicity of the anhydro-derivatives of
      tetracycline was also observed with respect to their teratogenic effect.
      Extremely pronounced anomalies in the embryo development were observed after
      exposure to 500gamma of 4-epianhydrotetracycline.

PMID- 1035489
TI  - [Polysaccharide biological activity dependent on structural characteristics].
AB  - Anti-Influenza and interferonogenic activity of polysaccharides from the glucane
      class produced extracellularly by the yeast-like organism Aureobasidium pollulans
      was studied on albino mice. The polysaccharides differed from each other by the
      branching level and content of bonds beta-C1-C3 and alpha-C1-C between the
      monomers. At the moment of the drugs administration to the albino mice the level
      of the early interferon was in correlation with the following 2 factors: the
      level of the polysaccharide branching and the percentage of bonds beta-C1-C3,
      while the amount of interferon produced in 24 hours correlated only with the
      percentage of bonds beta-C1-C4. The anti-influenza activity of the
      polysaccharides depended on the level of interferon production induced by them in
      the mice. Preparations stimulating production of sufficient amounts of both early
      and later interferon had the maximum activity.

PMID- 1035490
TI  - [The effect of formamide on the achromatic apparatus and the chromosomes of
      dividing pleurodele eggs: an electron microscope study].
AB  - Electron microscope studies of blastulae of Pleurodeles waltlii Michah., treated
      with formamide (0,5 M for 17 hours), show various abnormalities concerning
      centrospheres, chromosomes and microtubules as well. At the prophase stage, the
      centrospheres may display at their outer region an accumulation of dense bodies,
      which shows a temporary blocking of these centrospheres. At metaphase the poles
      of pluripolar mitoses appear more or less separated from the material which
      contains the chromosomes of the equatorial region. Each of these poles contains
      an unique centriole and therefore it is considered as resulting of the
      subdivision of a normal anaphasic pole. Astral and spindle microtubules are very
      reduced in number and more or less shortened. The chromosomes are without any
      recognizable kinetochcre, they show various degrees of condensation. All these
      electron microscope observations confirm the light microscope ones, and we may
      conclude that formamide has a double action on microtubules formation and on the
      ultrastructure of chromosomes, the latter perhaps by a direct action on DNA
      protein complexes.

PMID- 1035491
TI  - [Murine model for experimental studies on attenuated mutants of a Pasteurella
      multocida strain with pathogenicity for the calf. 1. Isolation and biological
      characterization of streptomycin-dependent mutants (Sm-d) and their examination
      for immunogenicity in comparison with thermally inactivated pathogens].
AB  - An experimental study was conducted into the immunisation of mice to a strain of
      Pasteurella multocida with pathogenicity for calf. Here are the results: (a)
      Stable Sm-d mutants were isolated. (b) The genetic stability of this mutant type
      was established by unsubstantiable reversion up to the magnitude of 10(-8) or -
      in cases in which 20 Sm-id revertants maximum occurred in 10(-8) Sm-d germs--by
      prolongation of the generation period of these suppressor mutants which can be
      defined also as minus mutants. (c) Stable attenuation of selected Sm-d mutants
      has been established in mice by intraperitoneal application of 108 germs. (d)
      Live germs with restricted reproduction exhibited more immunogenicity to
      thermally inactivated antigen.

PMID- 1035492
TI  - [Results of vaginal cytology studies and examination of the arborization
      phenomenon of the vaginal mucus for the determination of estrus cycle activity in
      sheep].
AB  - Vaginal smears were taken by means of a metal spatula from the dorsal part of the
      vaginal vestibule of sexually mature sheep with intach genitals for the purpose
      of following up changes in the vaginal cell structure. The smears were taken
      daily over the whole testing period of 35 days. The cells were defferentiated by
      means of the dyeing method according to Papanicolaou as well as by using Shorr's
      staining which had been modified according to Pundel. Differentiation was made
      between occurrences ob basal, parabasal, intermediary, and superficial cells,
      with the view to figuring out the cycle phases. That vaginal smear method, when
      used in two or three folloow-up examinations on the basis of random checks, has
      proved to enable determination of cyclic activity of a complete herd. This is of
      great importance to heart synchronization or heart induction, since all results
      so far have shown that all success depended strongly on the given degree of
      cyclic activity of the sheep concerned.

PMID- 1035493
TI  - [Grass tetany in cattle].
AB  - An optimal magnesium supply of dairy cows during pasture period is still a
      pressing problem in our farms and husbandry. Experiences are described concerning
      the application of different magnesium concentrated preparations in cases of
      grass tetany in 1970 to 1975 in the district of Potsdam. In 224 cows with
      magnesium concentrations values in the serum below 1.8 mg/100 ml a 25% MgSO4
      solution, Parevert and Vers. A, a test solution of VEB Tierarzneimittelwerk
      Leipzig are used as a metaphylactic treatment. Losses by grass tetany could be
      reduced after application of the named preparations. Also in cases of low dosage
      a further, at least temporary drop of magnesium values in the serum could be
      prevented. Metaphylactic measures are recommended for andangered herds.

PMID- 1035494
TI  - [A study of some etiological factors in hemorroidal disease (author's transl)].

PMID- 1035495
TI  - The absorption of nicotine from tobacco snuff through the nasal mucosa.

PMID- 1035496
TI  - Passive hemagglutination miniaturized technique for pox viruses and antigen
      identification using formalinized erythrocytes.

PMID- 1035497
TI  - [Mycotic panophthalmitis caused by Scopulariopsis brevicaulis].

PMID- 1035498
TI  - Artificial induction of lactation in ewes: the involvement of progesterone and
      prolactin in lactogenesis.
AB  - An attempt has been made to evaluate the importance of prolactin and
      'progesterone withdrawal' for lactogenesis. The experimental model system used
      was the ovariectomized, non-pregnant ewe induced to lactate artifically by
      treatment with trigger hormone (either oestrogen, glucocorticoid or oxytocin)
      alone or in combination with progesterone. It appears from the results that
      prolactin is important in the lactogenic responses elicited by oestrogen and
      oxytocin but not as important in the response elicited by glucocorticoid.
      Moreover, the results suggest that, in the ewe, an appropriate positive hormonal
      stimulus will overcome the inhibitory influence of progesterone on lactogenesis.

PMID- 1035499
TI  - [Basal gastrinemia in normal adults and newborn infants].

PMID- 1035500
TI  - The suppressive effect of halothane on DNA synthesis of immunocytes.
AB  - Mice, previously immunized with sheep erythrocytes, were anaesthetized with
      halothane and the splenic lymphoid cells were incubated with 3H-thymidine at 1-h
      intervals. Abiphasic response was observed; 0.9 and 1.5% halothane reduced 3H
      thymidine incorporation into the primed lymphoid cells by 83 and 94%
      respectively, while 0.4% halothane stimulated it by 5% of control at 3H.
      Immunosuppression by halothane may be the result of reduced 3H-thymidine uptake
      of the dividing immunocytes.

PMID- 1035501
TI  - [Enzymatic splitting of antibodies bound to immobilized antigen as a means of Fab
      fragments preparation].
AB  - A method of Fab fragments preparation by enzymatic splitting of antibodies bound
      to specific antigen immobilized on an insoluble support is described. The complex
      of rat muscle glyceraldehyde-3-phosphate dehydrogenase (GAPD), immobilized on
      Sepharose 4B, with anti-rat GAPD rabbit antibodies was digested with papain. The
      antigen was inaccessible to proteolysis under conditions employed. After 4 hrs of
      incubation with papain the antibody was completely split into non-precipitating
      fragments. The products of proteolysis not bound to Sepharose, were eluted with
      0.1 M givcine buffer pH 2.5, and shown to correspond to Fab fragments.

PMID- 1035502
TI  - [Results of free orthotopic ovary transplantation in minks].

PMID- 1035503
TI  - [Growth and functional activiy of the adrenal cortex during fetal development
      during exposure to hypoxic and hyperoxic conditions].
AB  - A study was made of lipid, cholesterol, and ascorbic acid content in the adrenal
      cortex of rabbit fetuses developing under conditions of normal pregnancy and
      under the action of hypoxic and hyperoxic exposures during its third trimester.
      It appeared that in normal pregnancy the adrenal cortex was activated, this being
      associated with the adaptive motor reactions of the developing fetus. The action
      of moderate hypoxic exposures led to a greater activation of moderate hypoxic
      exposures led to a greater activation of the adrenal cortex, this being expressed
      in a marked fall of lipid, cholesterol and ascorbic acid content. The weight of
      the total muscle mass and of the fetuses increased as a whole. The adrenal cortex
      became disactivated under conditions of the hyperoxic exposures; this is
      expressed in a marked increase in the content of the mentioned formations. The
      weight of the total mass and of the fetuses decreases.

PMID- 1035504
TI  - Interactions of antiestrogens with human breast cancer in long-term tissue
      culture.
AB  - A variety of antiestrogens can be shown to antagonize estrogen action in animal
      model systems. Several of these compounds are useful in the management of
      metastatic human breast cancer. To further elucidate their mechanism of action,
      we studied several of these compounds using human breast cancer cell lines
      maintained in long-term tissue culture as a model system. Antiestrogens including
      tamoxifen (NSC-180973; ICI-46474), nafoxidine. CI-628, and clomiphene citrate
      inhibit macromolecular synthesis below control levels in two human breast cell
      lines. This effect is limited to cell lines which contain estrogen receptors.
      Simultaneous addition of as little as 1000-fold less estradiol prevents
      antiestrogen effects. Sequential addition of estrogen for up to 48 hours to cells
      incubated in antiestrogen reverses inhibition. If cells are continued in
      antiestrogen alone for more than about 3 days, inhibitory effects become
      irreversible. The cells detach from the surface of the culture vessel and are no
      longer viable. Tamoxifen competes with 3H-estradiol for specific receptor sites
      but with about a 100-fold lower apparent affinity. Direct binding of 3H-tamoxifen
      and 3H-estradiol to duplicate cytoplasmic extracts reveals equivalent numbers of
      binding sites but a 20-fold lower affinity for the antiestrogen. There is
      reasonable agreement between concentrations of tamoxifen which bind to receptor
      and concentrations which inhibit cells.

PMID- 1035505
TI  - Evaluation of an intermittent schedule of dibromodulcitol in breast cancer.
AB  - Dibromodulcitol was administered orally on Days 1-10 every 3-4 weeks to 29
      patients with metastatic breast carcinoma refractory to previous combination
      chemotherapy. Initial doses between 70 and 280 mg/m2/day were utilized. The dose
      was escalated as tolerated in subsequent cycles in individual patients.
      Hematosuppression was dose-limiting. At doses of greater than 200 mg/m2/day
      leukopenia (greater than 1000 cells/mm3) and thrombocytopenia (greater than
      25,000 platelets/mm3) occurred in one of 28 cycles and two of 27 cycles
      respectively. In contrast, at doses of less than or equal to 200 mg/m2/day
      leukopenia and thrombocytopenia occurred in four of 18 cycles and five of 18
      cycles respectively. Recovery of leukocytes (less than 4000 cells/mm3) and
      platelets (less than 100,000 platelets/mm3) by Day 29 after the start of therapy
      was also delayed at higher doses. Responses were observed in three of 29
      evaluable patients and subjective improvement of osseous disease in one
      additional patient. A dose of 180 mg/m2/day X 10 Every 28 days is recommended in
      previously treated patients to avoid severe hematologic side effects.

PMID- 1035506
TI  - Rapid analytic method for adriamycin and metabolites in human plasma by a thin
      film fluorescence scanner.
AB  - A rapid and highly sensitive method is described for the quantitative
      determination of adriamycin and metabolites in plasma. Adriamycin (Ad) with
      daunorubicin added as the internal standard was extracted from plasma with
      chloroform-isopropanol (1:1), separated by thin-layer chromatography (TLC), and
      quantitated in situ via a fluorescence scanning technique. This method represents
      one of the very few reliable quantitative TLC methods and is suitable for the
      routine determination of Ad in plasma in amounts as low as 2 ng/ml. Plasma Ad
      levels at 24 hours in rabbits and in patients both given a 1-mg/kg dose,
      previously regarded as difficult to be measured, are now easily measurable using
      as little as 0.5 ml of plasma. Multiple samples (ten to 15) can be analyzed by
      this method within a day.

PMID- 1035507
TI  - Phase I study of oral mitomycin C.
AB  - This study demonstrates that the gastrointestinal absorption of oral mitomycin C
      is variable and that myelosuppression correlates most closely with the peak serum
      concentration. The probable maximal-tolerated dose of oral mitomycin C is 45-50
      mg/m2.

PMID- 1035508
TI  - Phase II study of methyl-CCNU in the treatment of advanced pancreatic carcinoma.

PMID- 1035509
TI  - [Use of pressure ultrafiltration for the determination of the binding capacity of
      a drug on human albumin and the plasma proteins of non-irradiated and irradiated
      female rats].

PMID- 1035510
TI  - Interaction between serum albumin and mercaptoundecahydrododecaborate ion (an
      agent for boron-neutron capture therapy of brain tumor). I. Introductory remarks
      and preliminary experiments.

PMID- 1035511
TI  - Interaction between serum albumin and mercaptoundecahydrododecaborate ion (an
      agent for boron-neutron capture therapy of brain tumor). II. Proposal of two
      interaction models.

PMID- 1035512
TI  - Interaction between serum albumin and mercaptoundecahydrododecaborate ion (an
      agent for boron-neutron capture therapy of brain tumor). III. Results of
      analysis.

PMID- 1035513
TI  - Effect of inorganic sulfur and selenium on O2-uptake and aniline hydroxylation by
      dithiothreitol-iron complex in comparison with adrenodoxin and Se-adrenodoxin.

PMID- 1035514
TI  - Preparation of a specific antibody to each one of catecholamines and L-DOPA.

PMID- 1035515
TI  - [Autoregulation of somatotropin secretion in acromegaly].

PMID- 1035516
TI  - [Experimental study and clinical application of prolactin radioimmunoassay kit
      (C.I.S.)].

PMID- 1035517
TI  - [Triiodothyronine radioimmunoassay-evaluation of T3 RIA kit].

PMID- 1035518
TI  - [Determination of blood prolactin levels in breast diseases using prolactin
      radioimmunoassay kits (CIS-Prolak Kit)].

PMID- 1035519
TI  - [Radioimmunoassay of the vasopressin content in the blood].

PMID- 1035520
TI  - [Present status of clinical neurology in Japan. (1) Epidemiological and clinical
      studies on multiple scerosis in Japan and Asia].

PMID- 1035521
TI  - [Present status of clinical neurology in Japan. (2) Motor neuron disease].

PMID- 1035522
TI  - [Present status of clinical neurology in Japan. (3) Polyradiculoneuopathy].

PMID- 1035523
TI  - [Present status of clinical neurology in Japan. (4) Myopathy--the present status
      and several problems].

PMID- 1035524
TI  - [Role of the reticulsr system on the pathogenesis of akinetic mutism].

PMID- 1035525
TI  - [Migraine pathophysiology: new vistas].

PMID- 1035526
TI  - [Effects and side effects of levodopa in parkinsonism- results of a collaborative
      study].

PMID- 1035527
TI  - [Effects and side effects of levodopa in parkinsonism-results of a collaborative
      study. (1) Therapeutic responses in relation to the etiology and clinical types].

PMID- 1035528
TI  - [Effects and side effects of levodopa in parkinsonism - results of a
      collaborative study. (2) The relationship between the age of the onset and
      therapeutic effects].

PMID- 1035529
TI  - [Effects and side effects of levodopa in parkinsonism - results of a
      collaborative study. (3) Side effects of levodopa].

PMID- 1035530
TI  - [Effects and side effects of levodopa in parkinsonism - results of a
      collaborative study. (4) Dyskinesia caused by levodopa].

PMID- 1035531
TI  - [Effects and side effects to levodopa in parkinsonism- results of a collaborative
      study. (5) Combined therapy with a peripheral decarboxylase inhibitor].

PMID- 1035532
TI  - [Disturbances of autoregulation in stroke. (1) Impaired regulation of water and
      electrolyte balance in cerebrovascular diseases].

PMID- 1035533
TI  - [Disturbances of autoregulation in stroke. (2) The Renin-angiotensin-aldosterone
      system].

PMID- 1035534
TI  - [Disturbances of autoregulation in stroke. (3) Abnormalities of respiratory and
      circuratory functions].

PMID- 1035535
TI  - [Disturbances of autoregulation in stroke. (5) Problems concerning oculomotor
      dysfunction].

PMID- 1035536
TI  - [Indication and prognosis of heterologous liver perfusion within the management
      of severe hepatic coma].

PMID- 1035537
TI  - [Effect of duodenal contents of patients with pancreatitis following its
      introduction into the duodenum of healthy rats].
AB  - The authors examined 18 rats--6 controls and 12 experimental. After duodenostomy
      by means of a puncure of the duodenal wall duodenal content from healthy persons
      was administered in the duodenum of control rats. In the experimental group of
      animals duodenal content form patients with pancreatitis was administered.
      Duodenum, pancrea, liver and kidneys were examined histomorphologicaly. The
      obtained results showed that there were no substantial deviations from the norm
      in the histomorphological picture of the examined organs after administration of
      duodenal content. In the organs of the experimental group these changes could be
      characterized as acute necrotic pancreatitis, acute duodenitis, acute finely
      dotted dystrophy of liver and slightly, manifested acute renal insufficiency. the
      authors suggested the occurrence of some toxic substances in the duodenal content
      in patients with acute pancreatitis.

PMID- 1035538
TI  - Subunit structure of 27 S thyroid iodoprotein.
AB  - The dissociation of thyroid 27 S iodoprotein by sodium dodecyl sulfate (SDS) and
      by succinic anhydride was investigated by means of ultracentrifugation and
      polyacrylamide gel electrophoresis. The iodoprotein obtained from either a human
      or hog was dissociated into three kinds of subunits (S-19, S-17 and S-12) by SDS
      treatment. At increased concentrations of SDS, the S-12 subunit was predominant
      among the dissociation products. The succinylation of 27 S iodoprotein showed
      essentially the same dissociation pattern as in the case of SDS treatment. This
      dissociation products of the protein preparations of different animals were
      qualitatively the same as those of thyroglobulin of the respective animals,
      confirming the hypothesis that 27 S iodoprotein was composed of two molecules of
      thyroglobulin. However, the extent of dissociation of 27 S iodoprotein measured
      by S-12 formation showed higher resistancy of the protein to the dissociating
      agents than that of thyroglobulin. The contents of sialic acid and hexose as well
      as iodoamino acids of 27 S iodoprotein were found to be the same as, or not far
      from, those of thyroglobulin; The dissociability and chemical composition of 27 S
      iodoprotein was discussed with reference to the subunit structure of the protein.

PMID- 1035539
TI  - A model for evaluation of the peroral insulin therapy: short-term treatment of
      alloxan diabetic rats with oral water-in-oil-in-water insulin emulsions.
AB  - Alloxan diabetic rats with fasting blood glucose levels above 300 mg/100 ml were
      treated with oral administration of water-in-oil-in-water (W/O/W) insulin
      emulsions at a dose of 50 U/100 g body weight, three times daily for 10 to 14
      days. The course of diabetes was followed by determinations of glucose levels in
      blood and urine. During treatment with oral W/O/W insulin emulsions, daily
      excretion of urinary glucose decreased by about 30 to 40% (2 to 3 g/day) in all
      of the five rats studied, and returned to the pre-treatment levels after the
      treatment being discontinued. During treatment, a significant reduction in
      fasting blood glucose levels was observed in 4 out of 5 rats, giving the decrease
      by 18 to 44%. Quantitative estimates suggested that the effectiveness of 50 U/100
      g of oral W/O/W insulin emulsions was comparable to that after intramuscular
      regular insulin at a dose of 0.5 U/100 g. Although oral W/O/W insulin emulsions
      are still of low efficiency, these results would indicate that diabetes can be
      controlled by effective oral insulin preparations.

PMID- 1035540
TI  - Pituitary function in reproductively senescent female rats.

PMID- 1035541
TI  - Assortative mating between chromosome forms of the mole rat, Spalax ehrenbergi.
AB  - Females of two parapatric chromosomal forms (2n = 52 and 2n =58) of the fossorial
      mole rat, Spalax ehrenbergi, in Israel, were tested for mate selection between
      two alternative, a homo- and a heterochromosomal, males. Estrous females
      significantly preferred the male of their own chromosomal form, on the basis of
      several behavioural criteria. The evolutionary significance of the positive
      assortative mating found, lies presumably in reinforcing reproductive isolation
      between the chromosome forms, thereby contributing to finalize speciation.

PMID- 1035542
TI  - Olfactory discrimination as an isolating mechanism in speciating mole rats.
AB  - Olfactory discrimination was tested in two chromosome forms of the speciating
      fossorial rodent, Spalax ehrenbergi, in Israel. Females of the chromosome forms
      2n = 52 and 2n = 58 were tested for male odour discrimination, the source of
      odour being either case litter or urine. Estrous females of both forms preferred
      homochromosomal odurs, whereas diestrous females showed no discrimination. These
      results suggest that olfactory discrimination may serve as a reproductive
      isolating mechanism in the speciation of mole rats.

PMID- 1035543
TI  - Evidence of diurnal fluctuation of sensitivity to noradrenaline in the rat-the
      role of the thyroid.
AB  - The capacity for heat production, under the influence of the same amount of
      noradrenaline, in the rat was significantly higher in the evening (20.00 h) than
      in the morning (07.00 h). Thyroidectomy produces not only a lower level of heat
      production, but also a complete disappearance of the differences between the
      morning and the evening experiments.

PMID- 1035544
TI  - Fine structrual relation between pancreatic excretory ductules and intercellular
      spaces.
AB  - Horse-radish peroxidase injected into the femoral vein of intact rats, or infused
      at 30 cm H2o pressure into the main pancreatic duct of intact dogs, entered
      easily the interstitial spaces surrounding acini and acinar cells. The latter are
      interconnected at their luminal segments by zonulae occuldentes. These junctions
      form a barrier to tracer penetrating from the interstituim towards the lumen of
      terminal ductules. However, the intraductally infused peroxidase entered the
      interstitial spaces, probably through the pressure injured acinar cells, as did
      colloidal carbon particles when infused intraductally.

PMID- 1035545
TI  - Foetal blood abnormality associated with hypodactyly in the hd strain of rat.
AB  - The homozygous foetuses of hypodactyl rats (hd strain) present an obvious red
      blood cell macrocytosis (day 14 of gestation). This blood abnormality could give
      rise to thrombosis leading to early necrosis of the extremities.

PMID- 1035546
TI  - [Role of the determinance factor in formation of systemic connections during
      ontogenesis].
AB  - Behaviour of differentiating neuroblasts was studied in the nervous tissue
      culture of the newborn rats cortex and medulla oblongata of the rabbit embryo.
      The phasic-contrast microscopy and study of fixated preparations revealed that
      distribution of the neuroblasts over the substrate, their mutual orientation, the
      character  of their branches growth and formation of contacts occur in vitro
      involving certain stages of morphological forming of the brain systemic
      organization. The clear trend of the neuroblasts behaviour to formation of
      certain connections suggests their genetic determinance. The distribution of
      neuroblasts over the substrate from different brain areas has its own phenotypic
      features.

PMID- 1035547
TI  - [Effect of fat on the evacuatory function of the stomach].
AB  - In dogs with a postpyloric fistula, the food with relatively large content of fat
      passed out of the stomach by equal portions although not exponentially. The size
      of these portions seem to be determined by the ability of small intestine to
      digest and absorb the portion of fat which has passed the pyloric sphincter.
      Besides, the fat in the food increases pH of chyme in the duodenum. Similar
      findings are reported for healthy subjects and patients with the duodenum ulcer.
      The inhibitory effect of fat on the stomach and duodenum motility depends on the
      initial background of contractile activity of the digestive tract. The positive
      role of fat in self-convalescence from the ulcer disease is suggested.

PMID- 1035548
TI  - [Role of Ca ions in the activity of mammary gland secretory cells].

PMID- 1035549
TI  - [Influence of change in feeding regime and food deprivation on circadian rhythm
      of adrenal cortical activity in rats (author's transl)].
AB  - The effects of food deprivation on circadian periodicity of plasma corticosterone
      levels were studied in adult male rats kept under regular light-dark alternation
      (light: 7 AM - 7 PM). Blood samples were obtained by tail vein sampling method.
      Plasma levels of corticosterone determined by this method were comparable to
      those obtained by decapitation both in the morning and evening. Twenty-four hour
      patterns of plasma corticosterone levels determined at 4 hour intervals using
      these two different methods were also essentially similar, indicating that the
      tail vein sampling method is reliable and useful for the study on adrenocortical
      rhythm. A restriction of feeding time between 10 AM and 6 PM for 2 weeks resulted
      in a phase shift of the circadian rhythm of plasma corticosterone levels. A peak
      appeared at 8 AM and the value was significantly higher than that at 6 PM. These
      findings confirmed the facts reported by Johnson and Levine, and Krieger. Overt
      circadian periodicity of plasma corticosterone levels persisted in rats fasted
      for three days. However, after the 5th day of food deprivation, the circadian
      rhythm was abolished and a flat 24 hour pattern of higher levels was observed.
      These results indicated that the feeding pattern plays an important role in
      establishing of circadian rhythm of adrenocortical activity.

PMID- 1035551
TI  - Ethanol production during the growth cycle of Aureobasidium pullulans.

PMID- 1035550
TI  - [Effects of ferulic acid on FSH, LH and prolactin levels in serum and pituitary
      tissue of male rats (author's transl)].
AB  - The existence of substances in corn germ, which induce a positive response in
      pigeon crop test, has been previously reported by Okamoto and Takahashi in 1974.
      Following this first experiment, one of these substances was identified as
      ferulic acid by purification. In the present experiment FSH, LH and prolactin
      levels in the serum and the pituitary tissue of castrated male rats and EP
      (estradiol benzoate and progesterone) treated male rats were determined by
      radioimmunoassay at 5 to 180 min. after intravenous injection with 1 mg of
      ferulic acid. It was noted that FSH release only was promoted significantly at 5
      min. after the injection, whereas LH and prolactin releases were inhibited at 5
      to 10 min. after the injection. A rebound effect was noted in LH and prolactin
      releases after the injection.

PMID- 1035552
TI  - Incorporation of [14C] palmitate into the lipids of cultured chick-embryo
      myoblasts.

PMID- 1035553
TI  - The effect of low concentrations of prostaglandin E1 on myoblast fusion.

PMID- 1035554
TI  - Steroidal control of protein synthesis in the developing chick embryo.

PMID- 1035555
TI  - Polyadenylated ribonucleic acid in normal and scrapie-infected mouse brain.

PMID- 1035556
TI  - Control of cell differentiation in the cellular slime mould Dictyostelium
      discoideum.

PMID- 1035557
TI  - Uric acid in pregnancy and toxaemia.

PMID- 1035558
TI  - Serum levels of gonadotropins during lactational amenorrhoea.

PMID- 1035559
TI  - Post partum vaginal smear in lactating and non-lactating.

PMID- 1035560
TI  - [Abortion. Report of a commission of the Paris Academy of Medicine].

PMID- 1035561
TI  - [Extragenital action of sexual hormones in woman].

PMID- 1035562
TI  - [Inhibitory effect of 2-(2-fluoro-4-biphenylyl)propionic acid (Flurbiprofen) on
      prostaglandin synthesis].
AB  - Inhibitory effects of 2-(2-fluoro-4-biphenylyl) propionic acid (Flurbiprofen, FP
      70) on prostaglandin (PG) synthesis and PG activity were investigated both in
      vivo and in vitro. FP-70 at 0.64 micronM showed 50% inhibitory effect on PG
      synthesis from arachidonic acid in cell-free homogenate of guinea pig lung. PGE2
      and PGF2alpha in the sample of lung homogenate incubated with arachidonic acid
      were separated by thin-layer chromatography in solvent AI system. FP-70 inhibited
      strongly both synthesis of PGE2 and PGF2alpha at 3 micron, but inhibited more
      extensively the synthesis of PGE2 than that of PGF2alpha at 0.3 micronM. FP-70 at
      1 mg/kg, p.o. inhibited mostly arachidonic acid potentiation of carrageenin
      induced edema in the rat paw, but did not inhibit PGE2 potentiation of
      carrageenin-induced edema. FP-70 also did not inhibit the contraction of rat
      stomach strip induced by PGE2. From the above and previously5) reported results,
      FP-70 proved to inhibit PG synthesis but not PG activity. It is suggested that
      the potent anti-inflammatory action of FP-70 is the result of inhibition of PG
      synthesis.

PMID- 1035563
TI  - [Effects of l-methyl-5-(O-fluorophenyl)-7-chloro-1,3-dihydro-2H-1,4-benzodiazepin
      2-One (ID-540) on operant behavior in rats].
AB  - Effects of ID-540, a new benzodiazepine derivative, on operant behavior were
      studied and compared with those of diazepam in rats for the purpose of
      determining the characteristics on behavioral pharmacology. Four schedules used
      were as follows: Fixed interval (FI-60sec) of food reinforcement and differential
      food reinforcement of low rate (DRL20sec) for positively reinforced behavior,
      Sidman-type avoidance response for negatively reinforced behavior and conflict
      behavior induced by simultaneously rewarding with food and punishing with
      electric shock. In the experiments on FI-60sec schedule, the responses at the
      early stage (0 approximately 30 min after administration of the drug) were
      increased by both ID-540 and diazepam at lower doses (0.5 approximately 4 mg/kg
      p.o.), but inhibited at higher doses (8 approximately 32 mg/kg p.o.). The effect
      of ID-540 lasted longer than that of diazepam. In the experiments on DRL20sec
      schedule, neither drug accelerated the responses, but decreased the lever-press
      response and total number of reinforcements at higher doses (4 mg/kg or more)
      showing the disturbance of discrimination on time. In Sidman-type avoidance
      responses, ID-540 did not show any inhibitory effect, thus a neuroleptic-like
      effect of ID-540 was not demonstrated. In experiments on FI-60sec and Sidman-type
      avoidance schedules, the effect of ID-540 was not changed by a consecutive
      administration for 10 days. Conflict behavior is considered to resemble the
      anxiety states in humans, and in related experiments, ID-540 increased the lever
      press response which delivered a food-pellet and an electric shock simultaneously
      at a dose of 0.0625 mg/kg (i.p.). Change in other behavior was not observed at
      this dose level. Maximum effect of ID-540 was observed at a dose of 0.5 mg/kg
      (i.p.). Maximum effect of diazepam on conflict behavior was seen at a dose of 4
      mg/kg (i.p.). The potency of ID-540 on conflict behavior was estimated to be
      about 8 times that of diazepam.

PMID- 1035564
TI  - [Activity of neurons of the hypothalamic suprachiasmatic nuclei and circadian
      rhythms: the role of the suprachiasmatic nuclei in rhythmic activities of neurons
      in the lateral hypothalamic area and ventromedian nuclei and the control of the
      pineal gland].
AB  - Unit activity of lateral hypothalamic area (LHA) and ventromedian nuclei (VMN)
      was recorded in urethane anesthetized male rats. A 5 to 10 sec, a 3 to 5 min and
      a circadian rhythmicity were observed. In about 15% of all neurons, spontaneous
      activity of LHA and VMN showed reciprocal relationships. Subthreshold stimuli
      applied at a slow rate in the septum and the suprachiasmatic nuclei (SCN)
      suppressed the rhythms without changing firing rates. On the other hand
      stimulation of the optic nerve at a rate of 5 to 10/sec increased firing rates in
      one third of neurons of SCN. Iontophoretically applied acetycholine increased 80%
      of tested neurons of SCN, whereas norepinephrine, dopamine and 5HT inhibited 64%,
      60% and 75% of SCN neurons, respectively. These inhibitions were much stronger in
      neurons, the activity of which was increased by optic nerve stimulation.
      Stimulation of the SCN inhibited the tonic activity in cervical sympathetic
      nerves. These data suggest that SCN plays a significant role in controlling the
      rhythmic activity of LHA, VMN and the pineal gland. Dopamine and 5HT may be
      involved in regulation of the firings of SCN neurons.

PMID- 1035565
TI  - [Role of the adrenergic system in lateral hypothalamic self stimulation behavior:
      effects induced by intraventricular injection of epinephrine, norepinephrine,
      isoproterenol and dopamine].
AB  - A bipolar electrode was stereotaxically implanted in or near the medial forebrain
      bundle at the level of the posterior lateral hypothalamus of male albino Wistar
      Imamichi rats. The relationship between the adrenergic system and the lateral
      hypothalamic self-stimulation (SS) behavior was investigated by intraventricular
      injection (by the use of the modelled hypodermic needle) of catecholamines. l
      Epinephrine(Ep), l-norepinephrine (NE) facilitated the SS behavior dose
      dependently. On the other hand, l-isoproterenol and dopamine revealed no
      detectable effects. Phentolamine inhibited the SS behavior, but propranolol had
      no marked effects. Facilitation by NE for the SS behavior was not induced when
      the current was cut off at the time of the injection of NE. These results suggest
      the following: a) the adrenergic or the noradrenergic system in the brain may
      play a more important role in the positive reinforcement of the lateral
      hypothalamic SS behavior than does the dopaminergic system. b) The action of Ep
      or NE may be facilitated through alpha-receptors rather than through beta
      receptors. c) Facilitation by NE for the lateral hypothalamic SS behavior may not
      be due to the non-specific facilitation of lever pressing, but rather may be
      related to intracranial stimulation.

PMID- 1035566
TI  - [Changes in the substantia nigal self-stimulation behavior caused by
      intraventricular injection of norepinephrine, dopamine and GABA].
AB  - A bipolar electrode was stereotaxically implanted in the substantia nigra of male
      albino Wistar-Imamichi rats. Effects of l-norepinephrine (NE), dopamine (DA) and
      gamma-aminobutyric acid (GABA), injected into the lateral ventricle, on the
      substantia nigral self-stimulation (SS) behavior, and the effect of alpha- and
      beta-adrenergic receptor antagonists on the facilitation induced by NE were
      investigated. NE but not DA facilitated the SS behavior and GABA showed no
      constant effects on the behavior. Facilitation by NE of SS behavior was inhibited
      by phentolamine, but not by propranolol. These results suggest that the
      noradrenergic system in the brain may play a more significant role in the
      positive reinforcement of the substantia nigral SS behavior than does the
      dopaminergic or GABA-ergic system, and that the action of NE may be facilitated
      through alpha-receptors rather than through beta-receptors.

PMID- 1035567
TI  - [Clinical presentation of chronic rheumatoid arthritis--its diagnosis and
      management].

PMID- 1035568
TI  - [Rheumatoid factor].

PMID- 1035569
TI  - [Chronic rheumatoid arthritis and complement].

PMID- 1035570
TI  - [Surgical management of the lower extremities in chronic rheumatoid arthritis].

PMID- 1035571
TI  - [Surgical management of the upper extremities in rheumatoid arthritis].

PMID- 1035572
TI  - [Clinical and pathological considerations of Plummer's disease (author's
      transl)].
AB  - Four cases of Plummer's disease were experienced and its clinical and
      pathological characteristics were considered. Clinically, three cases were
      thyrotoxic or slightly toxic, but one was non-toxic. Thyroid scintigrams showed
      hot nodules which revealed autonomic production of thyroid hormone, and the
      depleted uptake of 131I in the thyroid glands around the nodules was recovered to
      normal after the surgical extripation of the nodules. Histologic findings of the
      extripated nodules were follicular adenoma or adenomatous goitor. On electron
      microscopy, epithelial cells of the thyroid follicules in the nodules from all
      cases contained numerous secretory granules significantly increased in number,
      while development of the general cytoplasmic organelles varied from case to case.
      Capillaries in the nodules were fenestrated. Thus, the nodules were electron
      microscopically revealed active secretion of thyroid hormone. The electron
      microscopical examinations may be useful in the study of Plummer's disease.

PMID- 1035573
TI  - [Effect of S-propyl-mercapto-cysteine on lipid metabolism (author's transl)].
AB  - When intra tissue reduction of thiamine propyldisulfide (TPD) occurs the
      following changes take place : TPD+cysteine leads to thiamine+propyl-mercapto
      cysteine (PMC). We have reports that PMC has an effect of blood cholesterol
      lowering or not. In the present paper experiments were conducted to determine
      whether the effect of TPD on blood cholesterol lowering lies in PMC or not. The
      following results were obtained. 1) It was shown that when PMC was added to liver
      homogenate, no change was seen in the biosynthesis of cholesterol where TPD
      inhibited the biosynthesis. 2) When administered to normal animals while PMC
      showed no change in the total blood cholesterol value, TPD produced a decrease.
      While no change in total liver cholesterol value was induced by both, total
      liver, fatty acid showed a decrease by both. The biosynthesis of liver
      cholesterol from acetate-1-14C showed a decrease by both PMC and TPD, while the
      uptake from mevalonic acid-2-14C showed no change by both. The uptake of total
      liver fatty acid from acetate-1-14C while showing no change by PMC, showed an
      increase by TPD. 3) In cholesterol fed animals, the increase of blood cholesterol
      and total liver cholesterol was inhibited by TPD but PMC showed no effect. The
      biosynthesis of liver cholesterol from acetate-1-14C, showed an inhibitory effect
      on the lowering of biosynthesis in cholesterol fed animals by both TPD and PMC.
      And it was shown that the effect of TPD was larger. The total fatty acid value
      and the lowering of the uptake of total liver fatty acid from acetate-1-14C was
      inhibited to a similar extent by both TPD and PMC. From the above results, it may
      be said that even when PMC, a degenerative product of TPD is administered, either
      no effect is seen on the cholesterol metabolism or even when there is an effect,
      it would be negligible. Therefore, it may be surmized that the total structure of
      TPD exerts its effect on cholesterol and while the effect on fatty acid
      metabolism shows the same degree as TPD no characteristic features are seen.

PMID- 1035574
TI  - [Studies on screening for cholesterol-lowering agents using phenyl- and chromane
      substituted compounds (author's transl)].
AB  - Sixteen phenyl compounds and twenty chromane compounds substituted by geranoyl,
      farnesoyl, phytonoyl, retinoyl and linolenoyl synthesized by Eisai Co., Ltd were
      used. Male mice were fed a cholesterol or a normal basal diet which 0.3% compound
      was added for 10 or 31 days. Effect of these compounds on the cholesterol level
      of serum and liver were examined and compared to that of CPIB. As a results of
      this series of experiments hypocholesteremic agents were screened as follows: 3
      phenyl compounds (N76009, N76011, N76012), and 6 chromane compounds (N-76-H-23, N
      76-H-25, N-76-H-27, N-76-H-35, N-76-H-37, N-76-H-38). Among these compounds, N-76
      H-38, (formula: see text) was found to be the most favorable cholesterol-lowering
      agent.

PMID- 1035575
TI  - [Chemico-analytical studies on the water content of the human tissues. 1.
      Investigation of the method of oven-drying at 105 degrees C (author's transl)].
AB  - By heating at 105 degrees C in a constant temperature electric oven, a 35 ml
      crucible becomes completely dry in an hour and 2 grams of human tissue in 48
      hours. Within 5 minutes after taken out from an oven and allowed to stand in a
      room, a dried crucible and tissue become wet with moisture in the air and their
      water content reaches equilibrium and saturation. Thereafter the weight of the
      crucible remains constant for 5 days, that of the tissue for 30 minutes. A major
      portion of increased weight of a crucible containing tissue by moisture depends
      on the moisture of a crucible, whereas the moisture of tissue is extremely small
      being under 1.0%. Consequently it is sufficient to cool samples taken out from an
      oven in a room and to weigh within 30 minutes. There is no necessity for cooling
      them in a desiccator.

PMID- 1035577
TI  - [Seasonal changes in food consumption].

PMID- 1035576
TI  - [Experimental and clinical studies of transvenous electrophrenic respiration
      (author's transl)].
AB  - The transvenous electrophrenic respiration (EPR) is one of the effective and
      relatively simple method for artificial respiration. Twenty seven mongrel dogs
      were subjected to the experiment which were subdevided into 4 groups. Stimulation
      is 44 times in group 1, 22 times in group 2 and 3. Ventilation is carried out by
      Harverd Respirator in group 4. The normal arterial pressure, the normal minute
      ventilatory volume and the normal arterial blood gases were unchanged for a 5
      hour period of experiment in group 2. However, the frequent stimulation such as
      44 times/min. in group 1 yielded the hypotension, the decreased ventilatory
      volume and brought the congestion of the portal venous area and rendered the
      subjects to death. The systemic pressure remained in slightly lowered levels in
      group 2, 3 and 4 at the end of a 24 hour of experiment. The ventilatory volume
      decreased one third of initial values in group 2 and 3 at the end of a 24 hour of
      experiment. The pulmonary arterial pressure decreased in group 3 significantly,
      whereas it increased in positive pressure respiration in group 4. Intermittent
      clinical application of EPR was performed in three patients. The arterial
      pressure, minute ventilatory volume, arterial gases and central venous pressure
      were maintained normal. The following conclusions were obtained: 1) EPR is more
      physiologic than positive pressure respiration in ventilatory and circulatory
      aspects. 2) Undesiable conditions of stimulation cause complications such as
      neural fatigue, portal hypertension, etc. 3) Intermittent clinical application of
      EPR has been quite successful in supporting the ventilation of the patients.

PMID- 1035578
TI  - [Present status of hemodialysis in Hokkaido].

PMID- 1035579
TI  - Malpractice liability and PSRO. Part II.

PMID- 1035580
TI  - Genetic characterization of methotrexate-resistant chinese hamster ovary cells.
AB  - In a previous report, we described the selection and partial characterization of
      three methotrexate (Mtx)-resistant Chinese hamster ovary cells (CHO) (1). Class I
      cells contained an apparent structural alteration in dihydrofolate reductase.
      Class II cells had an alteration affecting the permeability of the drug. Class
      III cells, selected from Class I cells, had an increased activity of the altered
      enzyme. In the work described here, it has been shown that the spontaneous
      mutation rate to Class I resistance is in the order of 2 X 10-9 mutations per
      locus per generation and that in single-step mutagenized selections the number of
      resistant colonies of Class I and II are about equal. Class I and Class III
      resistance is expressed codominantly in somatic cell hybrids, whereas the Class
      II resistant marker is a recessive trait.

PMID- 1035581
TI  - Cytoplasmic inheritance in mammalian tissue culture cells.
AB  - A series of intraspecific, interspecific and interorder somatic cell cybrids and
      hybrids have been prepared by fusions in which one of the parents contained the
      cytoplasmically inherited marker for chloramphenicol (CAP) resistance. A clear
      relationship has been established between the expression of the CAP-resistant
      (CAP-R) determinants in the fusion products and the genetic homology of the
      parents. With increased genetic divergence, the acceptability of the CAP-R
      mitochondria decreased. Intraspecific cybrids and hybrids of the same strain were
      stable for the CAP-R marker, while those between strains were stable only in CAP.
      Intergeneric mouse-hamster cybrids occurred at a high frequency but were unstable
      in CAP, while CAP suppressed hybrid formation 100-fold. Interorder cybrids (CAP-R
      human X CAP-S mouse) occurred either at a moderate frequency and were stable at a
      low frequency and were unstable in CAP. Interorder hybrids could only be formed
      by challenging HAT-selected hybrids with CAP or by direct selection in ouabain
      and CAP. Reciprocal interorder crosses between CAP-R mouse and CAP-S human cells
      were unsuccessful. Interspecific cybrids contain only the chromosomes of the CAP
      S parent. Interspecific hybrids selected directly in CAP segregated the
      chromosomes of the CAP-S parent, while hybrids selected in HAT and then CAP
      segregated those of the CAP-R parent. The mitochondrial DNA(mtDNA) of all mouse
      human cybrids and most HAT and then CAP-selected hybrids contain only the mtDNA
      of the CAP-S mouse parent. However, preliminary evidence suggests that one of
      these hybrids contains both mouse and human mtDNA sequences.

PMID- 1035582
TI  - Time sequence and morphological evaluations of cells fused by polyethylene glycol
      6000(1).
AB  - Mouse L cells (clone 1D) were fused with polyethylene glycol (PEG). The fusion
      sequence was determined by using sequential light microscopy of the same group of
      cells, scanning electron microscopy (SEM),transmission electron microscopy, and
      freeze-etching. The cells were found to fuse only 1 min after PEG had been washed
      off at small localized areas. Larger fusion images were found after 3 min.
      Intramembrane particles were observed to have a tendency to aggregate after PEG
      treatment, but a direct correlation of this activity with the fusion process
      could not be made. No pathological changes were noted at longer times after PEG
      removal, except for the extensive widening of the rough-surfaced endoplasmic
      reticulum (RER) in some cells. It is proposed that fusion does not occur if
      apposing cells have many microvilli at the area of apparent contact.

PMID- 1035583
TI  - Absent left pulmonary artery with left arch and subaortic stenosis.

PMID- 1035584
TI  - Intra-oral temperatures in man with special reference to involvement of the
      central incisors and premaxillary alveolar process in lepromatous leprosy.
AB  - The predilection of lepromatous leprosy for body sites substantially below core
      temperature is well known, and within the oral cavity the premaxillary alveolar
      process and upper central incisor teeth are especially affected. In this study,
      intra-oral temperatures were recorded by means of a series of thermistor probes
      applied to the teeth and labial surfaces of the gums of normal subjects. The
      temperature distribution established showed a close correlation with the known
      pattern of involvement of teeth and supporting structures derived from clinical,
      pathological and archeological data. Relatively low temperature of the
      premaxillary alveolar process was demonstrated, a factor which may be of prime
      importance for the localization of disease in this region, as it is for other
      tissues in the lepromatous patient.

PMID- 1035585
TI  - Androgenic status of lepromatous leprosy patients with gynecomastia.
AB  - The androgenic status of 24 lepromatous leprosy male patients, 12 with and 12
      without gynecomastia, was studied in comparison with that of 12 normal healthy
      males. Plasma testosterone levels were significantly diminished in the
      gynecomastia group as compared to levels in either of the control groups. The
      patients without gynecomastia showed values not significantly lower than those of
      normal males. Histopathologic examination of the leprous testes showed a variable
      admixture of inflammatory, degenerative anf fibrotic changes which were more
      severe and more frequent in the patients with gynecomastia than in those without
      it. Parenchymatous liver function tests showed greater derangement in the
      gynecomastia group as compared to the controls Histopathology of the liver showed
      lepromatous infiltration in patients with and without gynecomastia though the
      changes in liver were minimal in patients who showed total testicular
      degeneration in the biopsies.

PMID- 1035586
TI  - Leprosy and the lipidoses.

PMID- 1035587
TI  - Study of subcutaneous fat in leprosy patients.

PMID- 1035588
TI  - Leprous myositis.

PMID- 1035589
TI  - Congenital dislocation of the hip in the newborn. A correlation of clinical,
      roentgenogrhic and anatomical findings.
AB  - This study correlates roentgenography, arthrography, morbid anatomy and histology
      in four newborn infants with congenital dislocation of the hip. Three died
      shortly after birth. In two of these, manipulative reduction was impossible. Both
      demonstrated secondary adaptive changes at autopsy, indicating that the
      dislocation had been present for some time in utero. The first had a paralytic
      dislocation (meningomyelocele), and the second showed no pathologic findings
      other than the dislocated hip. The third infant had a dislocation that was
      reduced at birth. The child died of pneumonia on the 15th day. At autopsy, no
      secondary adaptive changes were found in the hip. The fourth infant, who had
      undergone open reduction because of a dislocation irreducible at birth, was
      retrospectively found to have an intrauterine dislocation when the maternal
      roentgenogram was reviewed. Significant secondary adaptive changes were noted at
      the time of operation.

PMID- 1035590
TI  - PSROs and the legal protection of confidential information.

PMID- 1035591
TI  - How to overcome barriers to effective audit.

PMID- 1035592
TI  - Quality health care: another administrative nightmare.

PMID- 1035593
TI  - A mare mule--dam or foster mother?
AB  - A female, horse-like foal was apparently born to a mare mule from mating to a
      Shetland stallion. The presence of three pregnant Shetland mares in the same
      pasture, however, raised some questions about parentage, even though all three
      mares apparently gave birth to single foals within 6 weeks after the birth of the
      propositus. The transferrin system indicated that the foal was not born to the
      mare mule but was the offspring of one of the Shetland mares. Apparently one
      Shetland mare gave birth to twins 3 to 6 weeks apart, and the mare mule came into
      lactation spontaneously and adopted the first twin. The offspring was determined
      to be a horse by appearance, karyotype, blood type, and voice.

PMID- 1035594
TI  - Effect of maternal parity on aneuploidy in early mouse embryos.
AB  - An attempt to evaluate the incidence of chromosomal aneuploidy in mouse
      blastocysts recovered from females of various ages and parity levels revealed an
      insignificant regression coefficient for aneuploidy on age of the female and its
      square, and an insignificant correlation coefficient for aneuploidy with the
      number of previous offspring born to the dam. However, significant regression
      coefficients were obtained for aneuploidy on parity of the dam and its square.
      These results indicate that not only does aneuploidy increase with parity level,
      but the rate of increase accelerates as parity level increases. Possible
      explanations for the increase in aneuploidy and its detrimental effect on
      reproductive efficiency were discussed.

PMID- 1035595
TI  - [Cerebral circulation during hypothermia induced by perfusion cooling. Mass
      analysis and microsphere method].

PMID- 1035596
TI  - [Anomalous origin of the right pulmonary artery from the ascending aorta; report
      of a successful corrective surgery].

PMID- 1035597
TI  - [Changes of cortisol, LH and prolactin levels during open heart surgery under
      extracorporeal circulation].

PMID- 1035598
TI  - [Renal hemodynamics during extracorporeal circulation under normal temperature.
      Studies of total renal blood flow, intra-renal blood supply and changes in
      partial pressure in the tissue].

PMID- 1035599
TI  - [Follow-up study of intra-bronchial artery infusion of antineoplastic drugs
      before lobectomy in lung neoplasms].

PMID- 1035600
TI  - [Application of partial extracorporeal circulation in the surgical management of
      patent ductus arteriosus associated with hypertension in adults].

PMID- 1035601
TI  - [Experimental studies on emergency coronary artery reconstruction under
      hyperbaric oxygenation, with special reference to the improvement of surgical
      management in acute myocardial infarct].

PMID- 1035602
TI  - [Studies of hemodynamics following open heart surgery with impedance
      cardiography].

PMID- 1035603
TI  - [Open commissurotomy in mitral stenosis. Studies of 60 cases].

PMID- 1035604
TI  - [Emergency valve replacement in serious aortic valve insufficiency caused by
      bacterial endocarditis, with special reference to characteristic hemodynamics and
      problems with the Hancock valve].

PMID- 1035605
TI  - [Thymoma--diagnostic criteria for its malignancy].

PMID- 1035606
TI  - [Optimal coronary perfusion. 1. Experimental studies (devices and methods)].

PMID- 1035607
TI  - [Tetralogy of Fallot with anomalous coronary artery in an adult--a case study].

PMID- 1035608
TI  - [GC-MS].

PMID- 1035609
TI  - Use of factor analysis to classify strains of yeasts: application to genus
      Torulopsis Berlese.

PMID- 1035610
TI  - Stochastic selection in both haplophase and diplophase.
AB  - A population genetic model incorporating the evolutionary forces of zygotic
      selection, gametic selection and non-Mendelian segregation has been analyzed for
      the case in which all selection coefficients and the segregation parameter are
      assumed to be random variables that are uncorrelated from generation to
      generation. The diffusion approximation of the model is developed, and the
      subsequent analysis shows that one of four limiting outcomes of the stochastic
      process may obtain--an allele may be fixed or lost almost surely and irrespective
      of the initial gene frequency, the gene frequency may converge to a unique
      stationary distribution, or an allele may be fixed or lost with probabilities
      depending on the initial gene frequency. These outcomes correspond rather closely
      with the possible outcomes of the deterministic model--fixation or loss of an
      allele, convergence to a stable equilibrium, or the existence of an unstable
      equilibrium.

PMID- 1035611
TI  - Global stability in two species interactions.

PMID- 1035612
TI  - Predator prey interactions with time delays.
AB  - A general (Volterra-Lotka type) integrodifferential system which describes a
      predator-prey interaction subject to delay effects is considered. A rather
      complete picture is drawn of certain qualitative aspects of the solutions as they
      are functions of the parameters in the system. Namely, it is argued that such
      systems have, roughly speaking, the following features. If the carrying capacity
      of the prey is smaller than a critical value then the predator goes extinct while
      the prey tends to this carrying capacity; and if the carrying capacity is greater
      than, but close to this critical value then there is a (globally) asymptotically
      stable positive equilibrium. However, unlike the classical, non-delay Volterra
      Lotka model, if the carrying capacity of the prey is too large then this
      equilibrium becomes unstable. In this event there are critical values of the
      birth and death rates of the prey and predator respectively (which hitherto have
      been fixed) at which "stable" periodic solutions bifurcate from the equilibrium
      and hence at which the system is stabilized. These features are illustrated by
      means of a numerically solved example.

PMID- 1035613
TI  - Animal experiments on thiamine avitaminosis and cerebral function.
AB  - Before industrial production of thiamine becam possible, among many beriberi
      patients some showed symptoms of encephalopathy, the cerebral form of the
      disease. In this animal experiment, thiamine-deficient rats showed failure or
      blocking of the operant behavior in the maze box, pole climbing box and shuttle
      box, indicating orientation disturbance and defective memory. This Wernicke's
      syndrome-like sign dramatically disappeared by treatment with thiamine.
      Potentiated narcosis with thiopental or alcohol induced in thiamine-deficient
      rats and mice was readily reversible by thiamine administration. These phenomena
      are associated with thiamine content of the brain and are found long before
      histopathological changes in the brain of deficient animals. It is easily
      surmised that thiamine deficiency in the brain may block the brain metabolism and
      subsequently cause changes in any chemical substances in the brain, refracting on
      biophysical phenomenon, such as EEG. However, in the present study, generally
      speaking, no meaningful results concerning these points were obtained.

PMID- 1035614
TI  - Nucleotide precursor in riboflavin biosynthesis.

PMID- 1035615
TI  - [The fractionation of serum lipids by droplet countercurrent chromatography
      (authors transl)].

PMID- 1035616
TI  - [Studies on commercial cinnamon and allied barks. V. Variation in inner structure
      of the barks of Cinnamomum burmanni Bl. (author's transl)].

PMID- 1035617
TI  - [Studies on commercial cinnamon and allied barks. VI. Cinnamon and allied barks
      in Jawa Market. (author's transl)].

PMID- 1035618
TI  - [Reaction of sodium borohydride. II. Reduction of carboxylic acids and esters
      with sodium borohydride (author's transl)].

PMID- 1035619
TI  - [Studies on the constituents of leaves of Rhododendron degronianum Carr].

PMID- 1035620
TI  - [Protein binding of nonsteroidal anti-inflammatory agents. I. (AUTHOR'S TRANSL)].

PMID- 1035621
TI  - [Studies on tertiary amine oxides. LX. Reactions of 3,2'-diquinolyl 1-oxide with
      some nucleophiles in the presence of acylating agents (author's transl)].

PMID- 1035622
TI  - [Carboxypeptidases from germinating soybeans. II. Stability and some chemical and
      kinetic properties of carboxypeptidases Sa and Sb (author's transl)].

PMID- 1035623
TI  - [Microdetermination of 1-methyl-2-(2-naphthyl)aziridine in biological materials
      (author's transl)].

PMID- 1035624
TI  - [Inhibition by polyvinylpyrrolidone (PVP) of gastrointestinal absorption of
      salicylic acid and related compounds in rats and its mechanism from the point of
      intermolecular interaction (author's transl)].

PMID- 1035625
TI  - [Organic sulfur compounds. Separation and reaction of cis- and trans-1
      thioniabicyclo(4.4.0)decane bromide (author's transl)].

PMID- 1035626
TI  - [A new method for synthesis of 10-hydroxy-9-phenanthrenecarbonitrile derivatives
      (author's transl)].

PMID- 1035627
TI  - [Studies on pyrimido-1,4-diazepine derivatives. I. Reaction of 5,6-diamino-1,3
      dimethyluracil with ethyl beta-ketocarboxylate (author's transl)].

PMID- 1035628
TI  - [Studies on the chemical constituents of Rutaceous plants. XXXI. The chemical
      constituents of Xanthoxylum cuspidatum Champ. (Fagara cuspidata Engl.) (author's
      transl)].

PMID- 1035629
TI  - [Relation between serum level in human and dissolution rate of commercial
      chloramphenicol tablets (author's transl)].

PMID- 1035630
TI  - [Effect of 4-hydroxypyrazolo [3,4-d]pyrimidine on uricase activity (author's
      transl)].

PMID- 1035631
TI  - [Species specificity on the contents of anserine and carnosine (authors transl)].

PMID- 1035632
TI  - [Studies on the constituents of flowers. VI. On the components of the flower of
      Pueraria thubergiana Benth. (3) (author's transl)].

PMID- 1035633
TI  - [Analytical studies on the active constituents in crude drugs. II. Determination
      of glycyrrhizin in pharmaceutical preparations including glycyrrhizae radix by
      high-speed liquid chromatography (author's transl)].

PMID- 1035634
TI  - [On the constituents of the fruit of Arctium lappa (author's transl)].

PMID- 1035635
TI  - [Genetic difference in extinction of a conditioned behavior in mice (author's
      transl)].
AB  - The conditioned avoidance behavior from electric shock were examined in thirty
      male mice of inbred JCL: ICR and DDF with a newly-designed apparatus which had a
      wide square open field implanted shock-electrodes in floor and a fixed arc
      running path way where electric shock current could be delivered or not. Data
      were recorded on running traces and times from the start point to the goal and
      analysed statistically. 1. In acquisition training, both the JCL: ICR and the DDF
      acquired to run the way correctly and any difference between them could not be
      observed. While in extinction, the JCL: ICR were more rapid than the DDF. 2.
      After the 2nd acquisition training, all mice were trained to run of the field
      where electric shocks were delivered including the way. The DDF ran into the goal
      correctly along the way, while the JCL: ICR did not, but ran straight into the
      goal. The straight-trace of the JCL: ICR could not be changed by the following
      acquisition. 3. After a eight weeks' pause of acquisition, all mice were tested
      on retention without shock delivery. The both the JCL: ICR and the DDF ran
      correctly along the way, and showed a full score by a few trials of aquisition
      training. 4. No change in behavior between the strains was found when high
      voltage shock were delivered during running the way. But in evaluation trials
      after the delivery only the JCL: ICR showed some changes in running trace and
      time. 5. Arguments on the difference in the process of extinctions between the
      strains were proved that may be associated with the genetic difference of a
      inhibitory mechanism.

PMID- 1035636
TI  - Effect of deuterium oxide (D2O) on excitation-contraction coupling of skeletal
      muscle.

PMID- 1035637
TI  - UV effect on germ cell determinant and a proposed scheme for germ cell formation
      process in embryos of Xenopus laevis.

PMID- 1035638
TI  - [Relationship between endocrine and exocrine pancreatic functions. 1. Exocrine
      pancreatic function in diabetes mellitus].

PMID- 1035639
TI  - [Experimental pancreatic lithiasis].

PMID- 1035640
TI  - [Immunological study on protein-losing gastroenteropathy].

PMID- 1035641
TI  - [Clinical significance of antibody to hepatitis B core antigen (anti-HBc)].

PMID- 1035642
TI  - [Excretion of antibiotics into the bile juice in obstructive jaundice].

PMID- 1035643
TI  - [Diagnosis of drug hypersensitivity hepatitis by whole blood microculture technic
      and clinical observation of the cases with positive results].

PMID- 1035644
TI  - [Lymphocyte transformation induced by stimulation with liver nuclear membrane
      fractions; a study using the peripheral blood patients with liver diseases].

PMID- 1035645
TI  - [Metrical and histopathological studies on Japanese schistosomiasis of the colon
      associated with cancer].

PMID- 1035646
TI  - [A case of chronic painless pancreatitis (author's transl)].

PMID- 1035647
TI  - [Morphological studies on the papilla of vater, the minor papilla, peri-vaterian
      diverticulum, and the promontory: with special reference to their changes with
      aging and relations to pancreatico-biliary diseases (1)].

PMID- 1035648
TI  - [Morphological studies on the papilla of vater, the minor papilla, peri-vater: an
      diverticulum, and promontory (2): with special reference to their changes with
      aging and their relations to pancreatico-biliary diseases].

PMID- 1035649
TI  - [Analysis of limiting factors in visualization of drip infusion cholangiography].

PMID- 1035650
TI  - [Effect of the pancreatic blood flow on pancreatic exocrine secretion].

PMID- 1035651
TI  - [Experimental ulcerous cancer of the glandular stomach of the rat].

PMID- 1035652
TI  - [A case of liver cirrhosis treated by reinfusion of concentrated ascitis
      (author's transl)].

PMID- 1035653
TI  - [Acute heterocheilidiasis of the stomach (author's transl)].

PMID- 1035654
TI  - [Case of ovarian cancer associated with hyperamylasemia].

PMID- 1035655
TI  - [Vibratory sense threshold of chain-saw operators (author's transl)].

PMID- 1035656
TI  - [Chalk dust in the lecture room (author's transl)].

PMID- 1035657
TI  - [Seasonal variation of the twinning rate (author's transl)].

PMID- 1035658
TI  - [Statistical analysis of records of absence in primary schools (author's
      transl)].

PMID- 1035659
TI  - [Changes in the mean birth weight by gestational week at an obstetric service in
      Naha during the past twenty years (author's transl)].

PMID- 1035660
TI  - [A trial measurement of individual noise exposure by time-zone in a day (author's
      transl)].
AB  - Noise has been measured usually for a particular source or place and not for each
      individual exposed. It has been thought to be of great significance if individual
      noise exposure is recorded in various kinds of noise environment and auditory
      effects of noise on each individual can be discussed. The present study, having
      each of examinees carry 10-Channel Noise Exposure Meter with him, intended to
      know about dose or equivalent sound level (Leq) of individual nois exposure for a
      whole day and for each of eight time-zones in a day. The examinees were 12 male
      married workers in a factory manufacturing electronic machines in Kawasaki City,
      Kanagawa Prefecture, Japan. They were divided into two groups; those who were
      working in a noisy workshop (Group N, 8 workers) and those who were working in a
      less noisy workshop (Group N-N 4 workers). Time-zones were categorized as
      follows: (a) time from rising to leaving home for the place of work, (b)
      commuting time in the forenoon, (c) working time in the forenoon, (d) noon recess
      time, (e) working time in the afternoon, (f) commuting time in the afternoon, (g)
      time from returning home to going to bed, and (h) sleeping time. Leq (c) and Leq
      (b) were highest and Leq (h) was lowest for Group N among the eight Leq values in
      the day, while Leq (b) and Leq (f) were highest for Group N-N. Statistically
      significant differences of Leq for each time-zone between the two groups were
      found in Leq (c), Leq (d) and Leq (e), whose energy average sound levels for
      Group N and Group N-N were 84.2 and 59.4 dB, 72.7 and 61.4 dB, and 85.5 and 61.4
      dBrespectively. Energy average equivalent sound levels of Leq (24) were 81.0 dB
      for Group N and 66.7 dB for Group N-N. Leq (24) for Group N were primarily
      determined by the noise exposure in the working time (c and e), while those for
      Group N-N by that in the commuting time (b and f). Practical disadvantages in the
      course of individual application of 10-Channel Noise Exposure Meter were also
      pointed out. It was shown that it is possible individually to measure the noise
      exposure dose for each time-zone in a day or daily noise exposure pattern, and
      the noise exposure dose over 24-hour. It may be recommended that many typical
      noise exposure patterns and 24-hour noise exposure doses for each of the groups
      classified by sex, age, kind of job, kind of commuting methods, kind of
      residential area of residential area and so forth should be surveyed further,
      which will be useful for estimating the auditory effects of noise on a
      population. Also, the relationships between Leq and such effects as annoyance or
      interference with daily activities should be examined to ease the measurement of
      noise.

PMID- 1035661
TI  - Analysis of combined effects of benzene with radiation on chromosomes in cultured
      human leukocytes.
AB  - Three experiments were carried out on 53-hr cultured human leukocytes on
      chromosome mutagenicity of benzene with particular reference to combined effects
      with gamma-radiation and inhibitory effect on rejoining of radiation-induced
      chromosome breaks. The results and their analyses were summarized as follows: 1)
      Benzene can induce mainly chromatid-type deletions, especially gaps, suggesting
      that the cells in their late S-G2 stage have a higher susceptibility to
      chromosome breakage by benzene. 2) The aberration tield of dicentrics and rings
      induced by 100 rads irradiation can significantly be enhanced by the treatment of
      benzene equal to or in excess of 0.2 mM. 3) Quantitative analyses using newly
      defined "Synergetic effect factor" revealed that combined cytogenetic effect of
      benzene with radiation could be synergetic exclusively in dicentrics and rings,
      being almost additive in the other types of aberration. 4) The experiment with
      dosage fractionation method showed that the more strongly benzene could inhibit
      the rejoining of radiation-induced chromosome breaks, the higher concentration it
      was treated at. Related iwth these results, possible inducps, and the repair and
      its inhibition of radiation-induced DNA-strand(s) breaks. Further studies for
      related effects by benzene are needed on protein synthesis, activities of repair
      enzymes and fine structure of chromosomes.

PMID- 1035662
TI  - [An epidemiologic study on vibration hazards among workers at the state forests
      in Kyushu (author's transl)].
AB  - There are only very few reports of epidemiologic analysis on vibration hazards
      among the workers at the state forests of Japan since 1970. It was necessary to
      perform investigations on the state of vibration hazards anew, through some labor
      hygienic policies on the prevention of the hazards, such as regulation of the
      time of using vibrating tools, had been executed to some extent since 1970. From
      the data of physical check-ups of 861 chain saw users of 24 District Forestry
      Offices in Kumamoto, Miyazaki and Kagoshima Prefectures in the south of Kyushu,
      the transition of vibration hazards was studied by using the incidence and
      prevalence of Raynaud's phenomenon and paresthesia of the fingers as indices.
      From the yearly transition of the hazards, a tendency was observed of increasing
      patients with vibration syndrome during the period from 1962 to 1970 when
      countermeasures on vibration hazards were not sufficient. However, since 1970 the
      occurrence of Raynaud's Phenomenon has shown a tendency to decrease among the
      workers with short history of using chain saw and the occurrence of paresthesia
      of the fingers as indices. From the yearly transition of the hazards, a tendency
      was observed of increasing patients with vibration syndrome during the period
      from 1962 to 1970 when countermeasures on vibration hazards were not sufficient.
      However, since 1970 the occurrence of Raynaud's Phenomenon has shown a tendency
      to decrease among the workers with short history of using chain saw and the
      occurrence of paresthesia of the fingers to increase among those with long
      history. The results are suggestive of making clear the pathophysiology of
      vibration hazards.

PMID- 1035663
TI  - [Cross-checks of urinary delta-aminolevulinic acid, creatinine and specific
      gravity (author's transl)].

PMID- 1035664
TI  - [An improved method of direct colorimetric determination of hippuric acid in
      urine (author's transl)].

PMID- 1035665
TI  - [Occupational chronic arsenical poisoning. On the cutaneous manifestations
      (author's transl)].
AB  - A physical examination with detailed dermatological examination was made on 28
      Japanese male workers, 22 to 63 years old, who had been exposed to arsenic for
      one to 24 years, in processes manufacturing lead arsenate, calcium arsenate and
      so on to be used as insecticides. Many corn-like punctate keratoses were seen on
      the palms and soles of 7 workers. The histopathological features in 6 specimens
      of punctate keratoses of palms and other regions of 4 workers were
      hyperkeratosis, acanthosis and elongation of rete ridge, but no malignant
      changes, although there were mild disorderly arrangements in part of stratum
      malpighii. Multiple lesions of sharply demarcated dullred patch with scale were
      found on the trunk and extremities of 3 workers. These lesions
      histopathologically showed the typical feature of Bowen's disease. Characteristic
      bronze pigmentation on the trunk and extremities was seen in 6 workers, and 5 of
      these 6 workers showed tiny normal or depigmented skin (raindrops) throughout the
      involved areas. These corn-like punctate keratoses mainly on the palms and soles,
      multiple Bowen's disease and diffuse bronze pigmentation with raindrop areas of
      hypopigmentation on the trunk and extremities were manifest almost in the same
      individuals, and it was concluded that they were characteristic cutaneous
      symptoms of chronic arsenical poisoning. There was no correlation between the
      intensity of cutaneous manifestations and the term of exposure to arsenic.
      Cutaneous manifestations due to arsenic were generally recognized as follows:
      diffuse pigmentation appears at first in one to two years after exposure to
      arsenic, then punctate hyperkeratotic lesions appear mainly on the palms and
      soles, and Bowen's lesions occur after several years or more. The use of arsenic
      has been abandoned in this factory since January, 1971. Diffuse bronze
      pigmentation now seems to be considerably lightened, as long time has passed
      after exposure to arsenic. However, since punctate hyperkeratotic lesions on the
      palms, soles and others may, though rarely, undergo malignant transformations,
      new lesions of Bowen's  disease may further occur and these lesions may develop
      to invasive squamous cell carcinoma, physical examinations of the workers exposed
      to arsenic should be continued and careful observation of them is necessary for
      the future.

PMID- 1035666
TI  - [Work load due to stamping task as a simple repetitive hand work (author's
      transl)].
AB  - An experimental study was carried out on stamping task using no conveyers with
      short work cycle which was taken as featuring simple repetitive hand work. Each
      phase of this work was allowed to each subject. Seventeen healthy adults, 8 males
      and 9 females, were engaged in the 120 minutes, stamping task. They were tested
      by their function of concentration maintenance (TAF), by flicker frequency and 30
      items of subjective symptoms as advocated by the Japan Association of Industrial
      Health. Quantities of work for each 10 minutes were calculated. The results
      obtained were as follows: 1) Number of stamped cards by male subjects was more
      than that by female subjects. 2) Pace of work performance in the female subjects
      was being kept more in balance with their capacity in comparison with the male
      subjects. 3) The results of TAF and FF tests showed that the body load in the
      male subjects were greater than in the female subjects.

PMID- 1035667
TI  - [Health effect of long-term diet mercury contaminated tuna. Part II. Accumulation
      and retention of mercury and selenium in organs and clinical symptoms (author's
      transl)].
AB  - Health effects of long-term tuna diet in cats were examined. The cats were fed
      daily with three kinds of tuna, containing different concentrations of mercury
      and selenium. The following results were obtained. 1) A high correlation was
      noted between the amount of fish intake and the mercury level in hair and blood
      samples of cats. 2) Mercury levels in organs were elevated corresponding with the
      amount of tuna consumption, but the distribution of mercury in organs of cats
      exposed to mercury in tuna flake differed from that in tuna fresh meat. In the
      liver, the ratio of methyl mercury to the total mercury was very low with an
      average of 11.5% of the ratio. 3) With regard to selenium, there was no
      correlation between intake of selenium and selenium levels in the cerebrum,
      celebellum, and kidneys, exept in the liver (r=0.766). 4) None of the cats had
      definite methyl mercury poisoning, but some slight disturbances were noted in
      several cats.

PMID- 1035668
TI  - [Chromosome damage in cultured human leukocytes induced by chromium chloride and
      chromium trioxide (author's transl)].

PMID- 1035669
TI  - [Determination of aromatic amines by use of a dual-wavelength TLC scanner
      (author's transl)].

PMID- 1035670
TI  - [Performance of commercial gas detector tubes of toluene (author's transl)].

PMID- 1035671
TI  - [The distribution of total mercury, methylmercury and selenium in rat organs
      (author's transl)].

PMID- 1035672
TI  - Toxicity of propoxur to rats by subacute inhalation.
AB  - Male and female rats were exposed to propoxur (2-isopropoxyphenyl-N-methyl
      carbamate) aerosol, concentrations averaging 5.7, 18.7 and 31.7 mg/m3 air, for 6
      hours daily on five days in a week over a period of 12 weeks. The effects were
      depressions of plasma by 20 to 30%, and of erythrocyte and brain cholinesterase
      activities which were caused by the highest air concentration of 31.7 mg/m3. On
      the basis of the physical, biochemical, phamacokinetic and metabolic behaviors of
      propoxur, a maximum allowable concentration of 2.5 mg/m3 air is suggested.

PMID- 1035673
TI  - Studies on muscular strength-myogram (MSMG). Part 1. A new device of apparatus
      for measuring muscular strength-myogram.
AB  - 1. A new apparatus, consisting of a strain gauge and a carrier amplifier, was
      devised for measuring back muscular and shoulder arms strength by the author.
      This apparatus was applied for analysing myogenic disorder related to muscular
      fatigue or pain. 2. Muscular strength with load and its myogram were recorded
      simultaneously, and their changes during the exertion were analysed. 3. Muscular
      strength-myograms of sternocleidomastoid muscle, upper trapezius muscle, deltoid
      muscle, rhomboid muscle and lumbodorsal muscle were observed from the back
      muscular strength-myogram, and those of teres minor muscle and major pectoral
      muscle from the shoulder arm strength-myogram. 4. It seemed paradoxically that
      the amplitude of action myogram increased in proportion to the grade of lowering
      of muscular strength caused by muscular fatigue or pain.

PMID- 1035674
TI  - Aging and activity of 5-aminolevulinate hydrolyase in the blood of humans and
      rats.
AB  - Activity of 5-aminolevulinate hydrolyase (delta-aminolevulinic acid dehydrase,
      ALAD, EC 4.2.1.24) in the blood was determined in relation to age in humans and
      rats, and the following findings were obtained: (1) In the group which consisted
      of 47 women (mean age 46, ranged 24 to 62 years) living in a rural district,
      where the atmospheric lead concentration was 0.5 micron/m3, a significant
      negative correlation between ALAD activity and age was observed statistically (r
      = -0.54). However, in the group which consisted of 53 women of similar age group
      living in an urban district, where the atmospheric lead concentration was 1.9
      microng/m3, showed a lower level of the ALAD activity than that of the former
      group and no correlation was found r = -0.01) between ALAD activity and age. (2)
      The ALAD activity of intact rats showed a decrease with age. The decrease
      proceeds rapidly within 8 weeks of age and becomes stable after reaching 25 weeks
      of age or 300 g of body weight. The value of the activity after 25 weeks of age
      was about one tenth of that at 5 weeks of age or 100 to 130 g of body weight. (3)
      Fifteen intact rats weighing 240 to 705 g were divided into three groups
      according to their body weight and were injected with lead acetate solution
      equivalent to 1 mg Pb/kg intraperitoneally in order to examine the sensitivity to
      lead in rats that have variation of ALAD activity by age or by body weight. The
      ALAD activity of these rats fell to the same level in all groups independently of
      the activity or the body weight before injection.

PMID- 1035675
TI  - Changes of the vibratory sensation threshold in workers using vibrating tools.
AB  - Vibratory sensation thresholds of ten fingertips of each person were measured by
      each of the three frequencies in groups using three kinds of vibrating tools and
      the control groups. The subject groups were using leg-drill (n=37), chipping
      hammer (n=25) and chain-saw (n=19). The control groups were engaged in desk work
      or outdoor work in a bureau of forest management (n=24), a local forest office
      (n=30) and a gas company (n=22) (Table 1). The tested frequencies were 63 Hz, 125
      Hz and 250 Hz. The room temperature was kept at 20 degrees C. 1) The threshold
      values were found in such order as V greater than IV greater than III greater
      than I and II-finger in the subject groups, whereas I and V greater than II, III
      and IV-finger in the control groups. No significant difference between left and
      right hands was found in any group, both the subject and the control. 2) The
      threshold values were significantly higher in the chipping-hammer group and the
      chain-saw group than in the control (p less than 0.05 at 63 Hz, p less than 0.01
      at 125 Hz and 250 Hz). They were higher in the leg-drill group than in the
      control but it was statistically not significant. 3) Regression analysis was
      performed about age and experience-years of the subject groups which were thought
      to have an effect upon the threshold change. But the effect of both factors to
      the threshold values were small in all subject groups. 4) The patterns of
      threshold values made up by each of the three frequencies were different among
      the three subject groups. The chipping-hammer group had the higher vibratory
      sensation threshold shift in the order of 250 Hz, 125 Hz and 63 Hz, the leg-drill
      group had almost equal threshold shift among the three frequencies, and the chain
      saw group had the intermediate tendency between the other two groups. 5)
      Frequencies of 125 Hz and 250 Hz were more advantageous than that of 63 Hz in
      order to discriminate between the subject group and the control. Both 125 Hz and
      250 Hz vibratory sensation threshold should be measured to find early disorders
      of vibration disease if possible, because the relation between thresholds of 125
      Hz and 250 Hz was not so linear. 6) The observed significant differences of
      threshold values among the control groups were thought to be caused by different
      climatic circumstances.

PMID- 1035676
TI  - Polychlorinated naphthalenes in the surrounding environment of a reproduction
      factory of used transformer oil.

PMID- 1035677
TI  - [Studies on industrial styrene poisoning. (Part VI) Styrene concentrations in
      alveolar air and blood of styrene workers and styrene exposed animals (author's
      transl)].

PMID- 1035678
TI  - Cold water immersion test in patients with vibration disease.
AB  - Peripheral vascular disorder is one of the most important symptoms in diagnosing
      vibration disease. Several kinds of tests have been introduced to evaluate the
      peripheral vascular function. Among those tests, cold water immersion test has
      been mostly applied. In Japan, the generally used method is to measure the skin
      temperature of one finger of the hand immersed up to the wrist joint in water at
      5 degreesC for 10 minutes. However, because the suffering during the test is so
      severe and some unfavorable warning symptoms have been observed during group
      examinations, a safer and milder method is more desirable. In order to examine
      the applicability of the test by using water at 10 degreesC in comparison with
      that at 5 degreesC, and to know the degree of suffering during the tests, a
      comparative study was performed. Sixteen students and 29 patients with vibration
      disease joined in this study. The results suggest that water at 10 degreesC can
      be effective stimulus, if the immediate rewarming response is used for
      evaluation. The self-rating scores revealed that the suffering was milder in case
      of water of 10 degreesC than at 5 degreesC for both the students and the
      patients. And the patients seemed to suffer more from chest discomfort than the
      students.

PMID- 1035679
TI  - [Factor analysis of Cornell Medical Index and Medical Data Index (author's
      transl)].
AB  - Structures of Cornell Medical Index and Medical Data Index were examined by
      factor analysis. Both of the translated questionnaires were self-administered by
      six hundred male employees. Questions of low response rate less than 5 and 6%
      were excluded, and 117 and 70 questions were analysed finally by the method of
      varimax rotation for CMI and MDI respectively. Ten factors were extracted.
      Cummulated contribution ratio of them amounted to 72.0 and 84.1% for CMI and MDI
      respectively. The first two factors were common for the both questionaires and
      had pronounced contribution ratio amounting to 36.7 and 29.3% for CMI and MDI
      respectively. The first factors was composed of questions related to autonomic
      inbalance, gastrointesinal symptom and fatigue, so it was named a tendency of
      many physical complaints. This factor was considered to be characteristic and
      representative one in such general health questionnaires, which was closely
      related to response set of the respondent. The second factor of the
      questionnaires was named mental instability. The two major factors would
      correspond to the first and the second component of the Subjective Fatigue
      Complaint Test (1970) by Japan Association of Industrial Health. Not also CMI but
      MDI were found to have a poor scalability except for the two major factors.

PMID- 1035680
TI  - [Personnel sampler for organic solvents in air (author's transl)].

PMID- 1035681
TI  - Inhibition of repair of radiation-induced chromosome breaks. Effect of phenol in
      cultured human leukocytes.

PMID- 1035683
TI  - [MUMPS (MGH utility multi-programming system), data-base language for medical
      information processing].

PMID- 1035682
TI  - [Atmospheric concentrations of lead alkyls in shipping containers carrying
      antiknock compounds (author's transl)].

PMID- 1035684
TI  - [Extraction of the left ventricular boundary form the radioisotope
      angiocardiogram].

PMID- 1035685
TI  - [X-ray imaging and its guantitative measurement using an x-ray microbeam].

PMID- 1035686
TI  - [Analysis of basic characteristics of the magnetocardiogram].

PMID- 1035687
TI  - [Source of errors in clinical tests--the problems of quality control in
      physiological tests].

PMID- 1035688
TI  - [Effects of signal-shock contingency probability on gastric lesions in rats as a
      function of shock region (author's transl].
AB  - Effects of signal-shock contingency probability on stress pathology were studied
      with 2 regions of electric shock and with (a) only sound signal presentations
      (NS), (b) unrelated presentations of the signal and tail shock (TS) or foot shock
      (FS) (NPS), (c) signal presentations all of which were paired with the TS or FS
      (100 PS), or (d) signal presentations, 50% of which were paired with a TS or FS
      (50 PS). Rats in NPS and 50 PS groups with TS showed more stress-induced
      pathology than animals in the 100 PS groups with TS. However, the 100 PS group
      with FS resulted in greater gastric lesions than NPS, 50 PS, or NS group. The
      interaction between shock region and signal-shock contingency probability plays
      an important role.

PMID- 1035689
TI  - [Functional hemispheric asymmetries in perception of digit and line orientation
      orientation (author's transl)].
AB  - In Exp. I, right-handed Ss made the "same" or "diffeeent" judgement to paired
      digits serially presented to the right and left visual field, and exhibited
      erroneous judgements in the left visual field lead condition. These results
      suggest the left hemisphere superiority. In Exp. II, the Ss were requested to
      make the "same" or "different" judgment and to press a key as fast as possible to
      the paired line orientation. The right visual field lead condition product more
      errors than the left visual field lead condition. This suggests the right
      hemisphere superiority. But no difference appeared between both conditions in the
      reaction time. The opposite hemispheric superiority, found in perceiving verbal
      and non-verbal materials in the 2 experiments, would be attributed to the basic
      difference in "perceptual" process.

PMID- 1035690
TI  - [Spectral analytical study on the developmental properties of EEG in children:
      Generalized and localized components of EEG spectra in the normal and the
      mentally retarded children (author's transl)].
AB  - The purpose of the present study was to elucidate the developmental properties of
      EEG in the normal and the mentally retarded children through regional differences
      and regional regional interrelationships. The localized components appearing at 1
      or 2 regions tended to show low coherences in relation to the occipital region.
      The generalized component, observed over all regions, indicated lower coherences
      in the theta component than in the alpha one. It may be inferred that the theta
      component shown in the developing children may be differenciated from the
      component around 10 Hz.

PMID- 1035691
TI  - [An experimental approach to eye-movements: comparison of response patterns
      between normal subjects and schizophrenic patients (author's transl)].
AB  - This experiment attempted to analyse eye movements (opthalmograph) when Ss freely
      observed 7 types of stimuli projected on the screen. 2 kinds of Ss, a normal
      control group (5 males, 5 females) and a schizophrenic experimental group (6
      males), participated and their response patterns were compared. The results
      indicated that the schizophrenic group was inferior to the normal Ss in the
      number of fixations, the mean duration of single fixation, the scan path patterns
      of the eye mark, the frequency changes of the eye movements within a presentation
      time, and the dispersion of fixations. These results seemed to show that the
      schizophrenic group was not able to process much information, and had poor
      contact with the outer world.

PMID- 1035692
TI  - [Systematization of pulmonary function tests. (1) Systematization of screening].

PMID- 1035693
TI  - [Systematization of pulmonary function tests. (2) Systematization of mass
      screening in relation to air pollution].

PMID- 1035694
TI  - [Systematization of respiratory function tests for pneumoconiosis].

PMID- 1035695
TI  - [Systematization of pulmonary function tests - chronic obstructive lung
      diseases].

PMID- 1035696
TI  - [Systematization of management of patients with severe respiratory diseases -
      analytical approach to mechanical ventilation].

PMID- 1035697
TI  - [Systematization of patient care in severe respiratory diseases.--a clinical
      aspect].

PMID- 1035698
TI  - [Asbestos pollution of the lung. (1) Incidence of asbestos bodies found in the
      lung and sputum].

PMID- 1035699
TI  - [A case of allergic bronchopulmonary aspergillosis (author's transl)].

PMID- 1035700
TI  - [Functions of the intestines, colon and rectum in congenital Hirschsprung's
      disease].

PMID- 1035701
TI  - [Experimental model of intestinal aganglionosis].

PMID- 1035702
TI  - [Physiological studies of aganglionosis].

PMID- 1035703
TI  - [Etiological study of Hirschsprung's disease].

PMID- 1035704
TI  - [Autonomic nerve control of the intestines in aganglionosis and its embryogenetic
      study].

PMID- 1035705
TI  - [Action potentials and internal pressure changes at the lower esophageal junction
      in rabbits and cats].

PMID- 1035706
TI  - [Esophagogastric junction--its function and abnormality in man].

PMID- 1035707
TI  - [Factors contributing to the closing mechanism of the cardia and its surgical
      reconstruction].

PMID- 1035708
TI  - [Internal pressure of the lower esophageal function and electromyography].

PMID- 1035709
TI  - [Problems of excitation-contraction coupling].

PMID- 1035710
TI  - [Excitation-contraction coupling of the smooth muscle].

PMID- 1035711
TI  - [Mode of movement of the lower esophageal sphincter].

PMID- 1035712
TI  - [Experimental studies of esophageal circulation determined by intratubal
      induction].

PMID- 1035713
TI  - [Abnormal regulation of the lower esophageal sphincter function and
      gastrointestinal hormones].

PMID- 1035714
TI  - [Effects of ligation of vessels and various drugs on esophageal and cardiac
      circulation].

PMID- 1035715
TI  - [Response of esophageal movement and lower esophageal sphincter function
      following exogenic gastrin administration, with special reference to
      intraesophageal pressure].

PMID- 1035716
TI  - [Determination of internal pressure of the lower esophagus and cardia during
      surgery].

PMID- 1035717
TI  - [Effects of divalent and trivalent ions on the membrane excitation of the uterine
      smooth muscle of the pregnant rat].

PMID- 1035718
TI  - [Effects of oxytocin on endometrium].

PMID- 1035719
TI  - [Calcium ion in activation mechanism of guinea pig taenia coli cells].

PMID- 1035720
TI  - [Catecholamine contraction mechanism in tracheal smooth muscle of dogs].

PMID- 1035721
TI  - [Liberation mechanism of catecholamine from uptake 2 site in guinea pig vas
      deferens].

PMID- 1035722
TI  - [Effects of temperature on the slow wave of stratum circulare in the guinea pig
      stomach].

PMID- 1035723
TI  - [Effects of phospholipase C on stratum longitudinale of the guinea pig stomach].

PMID- 1035724
TI  - [Contraction and relaxation of vascular smooth muscle. Comparison of the origins
      of calcium employed in high potassium contraction and norepinephrine
      contraction].

PMID- 1035725
TI  - [Increased 45Ca uptake by the vascular smooth muscles caused by palytoxin].

PMID- 1035726
TI  - [Effects of bradykinin on the smooth muscle of cerebral artery].

PMID- 1035727
TI  - [Spontaneous contraction of bovine mesenteric lymph vessel].

PMID- 1035728
TI  - [Ulstructure of bovine mesenteric lymph vessels].

PMID- 1035729
TI  - [Generation and transmission of excitation in the pyeloureteral system of dogs].

PMID- 1035730
TI  - [Functions of the upper urinary tract. 9. Study of circulatory activities of the
      ureter by polarography].

PMID- 1035731
TI  - [Ganglionic and direct control of the bladder by the sympathetic nerve].

PMID- 1035732
TI  - [Neural control of the biliary tract of guinea pigs].

PMID- 1035733
TI  - [Effects of C-terminal octapeptide CCK and prostaglandin on the cholinergic
      action mechanism of the excised guinea pig gallbladder and Oddi's sphincter].

PMID- 1035734
TI  - [Effects of 3-(2',4',5'-triethoxybenzoyl)propionic acid on biliary pressure curve
      in rabbits].

PMID- 1035735
TI  - [Cineradiographic observation of gallbladder contraction].

PMID- 1035736
TI  - [Cineradiographic observation of gallbladder movement in man].

PMID- 1035737
TI  - [Mucosal structure of the biliary papilla and terminal of the biliary duct].

PMID- 1035738
TI  - [Bile excreting mechanism following trans-duodenal sphincteroplasty[].

PMID- 1035739
TI  - [Spinal center associated with defecation in guinea pigs].

PMID- 1035740
TI  - [Anal muscle participation in anorectal manometry].

PMID- 1035741
TI  - [Rectal and anal movement in a non-excised, free state].

PMID- 1035742
TI  - [Pathological studies of the rectum and the levator ani muscle in atresia ani].

PMID- 1035743
TI  - [Upward transmission of contraction in the isolated guinea pig intestine during
      its extension period].

PMID- 1035744
TI  - [Effects of prostaglandin in acetylcholine release from the isolated guinea pig
      intestine].

PMID- 1035745
TI  - [Effects of purine nucleotides on the parasympathetic nervous system. (8)
      Relationship between acetylcholine release and adenine nucleotides].

PMID- 1035746
TI  - [Cineradiographic observation of intestinal movement].

PMID- 1035747
TI  - [Fluorescence histochemical studies of enteric plexus in man].

PMID- 1035748
TI  - [Role of the enteric nervous system in intestinal movement of Geoclemys
      reevesii].

PMID- 1035749
TI  - [Neural control of the corpus and cervix uteri].

PMID- 1035750
TI  - [Proceedings: Sympathetic nervous regulation of oviduct movement].

PMID- 1035751
TI  - [Effects of prostaglandin on the electromyogram and contraction of the isolated
      oviduct].

PMID- 1035752
TI  - [Effects of prostaglandins on the electric activity of the rabbit oviduct].

PMID- 1035753
TI  - [Effects of various prostaglandins on the isolated dog trachea].

PMID- 1035754
TI  - [Effects of prostaglandins on the vascular smooth muscles].

PMID- 1035755
TI  - [Effects of verapamil on the prostaglandin-induced contraction of the gastric
      smooth muscle of the guinea pig].

PMID- 1035756
TI  - [Effects of prostaglandin F2alpha on the intestinal motility following surgery].

PMID- 1035757
TI  - [Continuous long-term recording of gastric motility rhythm].

PMID- 1035758
TI  - [Gastrointestinal movement in hunger].

PMID- 1035759
TI  - [Factors responsible for changes of gastric movement].

PMID- 1035760
TI  - [Electric activities of the stomach during wake-sleep cycle in dogs].

PMID- 1035761
TI  - [Electomyographic studies of the smooth muscle in gastrointestinal movement in
      man by endoscopic induction].

PMID- 1035762
TI  - [Inhibitory action of gastrin on gastrointestinal movement].

PMID- 1035763
TI  - [Effects of motilin on gastrointestinal movement].

PMID- 1035764
TI  - [Splanchnic nerve control of gastric function].

PMID- 1035765
TI  - [Effects of exogenous nerve excision on intragastric pressure].

PMID- 1035766
TI  - [Effects of vagotomy and sympathectomy on the motility and drug sensitivity of
      the excised rat stomach].

PMID- 1035767
TI  - [Electromyographic changes of the stomach during electric stimulation of the
      gastric branches of the vagus nerve].

PMID- 1035768
TI  - [Relationship between the localization of experimental stomach ulcer in dogs and
      electromyography].

PMID- 1035769
TI  - [Electromyographic differences between the curvatura ventriculi major and minor].

PMID- 1035770
TI  - [Pacing of the stomach following transection and anastomosis].

PMID- 1035771
TI  - [Effects of vogotomy on pacing].

PMID- 1035772
TI  - [Studies of gastric functions during 10 years following vagotomy, fixation of the
      anterior wall and pyloroplasty].

PMID- 1035773
TI  - [Vagotomy by cryosurgery].

PMID- 1035774
TI  - [Experimental studies on the changes of gastric movement following vagotomy of
      the trancus vagalis].

PMID- 1035775
TI  - [Action potentials of the stomach during vagotomy, especially during SPV
      (selective proximal vagotomy)].

PMID- 1035776
TI  - [Relationship between selective proximal vagotomy plus pyloroplasty and the
      electromyogram of the canine stomach].

PMID- 1035777
TI  - [Canine gastric movement during excision of pyloric antrum branch].

PMID- 1035778
TI  - [Incarcerated obturator hernia as a cause of intestinal obstruction].

PMID- 1035779
TI  - Delayed hypersensitivity tests with Mycobacterium leprae purified protein
      derivative.
AB  - Skin tests were conducted on 3 lepromatous, 3 dimorphous and 6 tuberculoid
      leprosy patients and 3 others not suffering from leprosy with lepromin, purified
      protein derivative from M. leprae of armadillo origin and tuberculin. Results
      show that a delayed hypersensitivity reaction could be produced with PPD in 72
      hours on all Mitsuda positive cases, with one anomalous exception, without cross
      reaction to tuberculin. The results were promising from the point of view of
      substituting lepromin with PPD in usual tests.

PMID- 1035780
TI  - Microtubules and actin filaments in teleost visual cone elongation and
      contraction.
AB  - Teleost retinal cones contract in light and elongate in darkness. This paper
      describes the disposition of microtubules and cytoplasmic filaments in cone cells
      of 2 species of fish (Haemulon sciurus and Lutjanus griseus). In Haemulon, the
      neck-like "myoid" region of the cone changes in length from 5 mu to 75 mu.
      Maximal observed rates of elongation and contraction are comparable to that of
      chromosome movement in mitosis (2-3 mu/min). Microtubules presumably participate
      in cone elongation, since numerous longitudinal microtubules are present in the
      myoid region, and colchicine blocks dark-induced elongation. Myoid shortening, on
      the other hand, appears to be an active contractile process. Disruption of
      microtubules in dark-adapted cones does not produce myoid shortening in the
      absence of light, and light-induced myoid shortening is blocked by cytochalasin
      B. Cone cells possess longitudinally-oriented thin filaments which bind myosin
      subfragment-1 to form arrowhead complexes typical of muscle actin. Myoid thin
      filaments are clearly observed in negatively stained preparations of isolated
      cones which have been disrupted with detergent after attachment to grids. These
      myoid filaments are not, however, generally preserved by conventional fixation,
      though bundles of thin filaments are preserved in other regions of the cell.
      Thus, actin filaments are poorly retained by fixation in precisely the region of
      the cone cell where contraction occurs. Cone cells also possess longitudinally
      oriented thick filaments 130-160 A in diameter. That these thick filaments may be
      myosin is suggested by the presence of side-arms with approximately 150 A
      periodicity. The linear organization of the contractile apparatus of the retinal
      cone cell makes this cell a promising model for morphological characterization of
      the disposition of actin and myosin filaments during contraction in a nonmuscle
      cell.

PMID- 1035781
TI  - The surface events of fertilization: the movements of the spermatozoon through
      the sea urchin egg surface and the roles of the surface layers.
AB  - The sea urchin egg surface at fertilization has been examined with the scanning
      electron microscope to reveal the movements of the spermatozoon from the
      exterior, through the surface layers, and into the egg cytoplasm. The layers that
      the spermatozoon encounter have been studied to determine their physical and
      chemical natures and their role in early development. By studying the outside of
      whole eggs and the inner face of surfaces isolated shortly after fertilization,
      it has been possible to compile data on the movements of the spermatozoon through
      the egg surface. The spermatozoon initially contacts the egg with the elongated
      acrosomal process. The vitelline sheet, the outermost layer of the egg, separates
      slightly next to the attached spermatozoon. As membrane fusion between the
      gametes occurs, the plasma membrane from the egg engulfs the spermhead, the
      cortical granules start to discharge their contents, and a spreading surface
      deformation, concommitant with a distortion of the fibrous cortex, is initiated.
      A cluster of elongate microville surround the perpendicularly fusing
      spermatozoon. These microvilli interidigitate as the spermatozoon is forced to
      lie upon the egg surface between the plasma membrane and the matrix of cortical
      fibers. The spermatozoon then rotates additionally to enter the egg cytoplasm
      with the posterior end first; it has rotated 180 degrees through the cell
      surface. Finally, it detaches into the egg cytoplasm, leaving a scar in the
      cortex through which it penetrated. The egg cortex, previously unobserved by
      electron microscopy, is revealed to be composed of 50-200 nm fibers. At
      fertilization they are uniformly organized but during later development this
      order is lost. The cortex is from 0.2-0.5 micronm thick and is a contractile
      structure. The role of the outer surface in releasing the cell from the metabolic
      constraints of the unfertilized egg is shown, and the apparent differences in the
      mobilities of the membranes derived from the sperm and from the egg are
      demonstrated. The relation of these layers to the movements of the spermatozoon,
      to the activation of the egg, to the block to polyspermy, and to each other are
      discussed.

PMID- 1035782
TI  - Confidentiality of alcohol and drug abuse patient records.

PMID- 1035783
TI  - A report on the national professional standards review council meeting May 3-4,
      1976; Washington, DC.

PMID- 1035784
TI  - National Health Planning and Resources Development Act of 1974.

PMID- 1035785
TI  - PSRO communications. Regulations--program manual transmittals--memos of
      understanding.

PMID- 1035786
TI  - Immobilization and steroid-transforming microorganisms in polyacrylamide.

PMID- 1035787
TI  - Monitoring of air and water for enzyme inhibitors.

PMID- 1035788
TI  - On the potential of soluble and immobilized enzymes in synthetic organic
      chemistry.

PMID- 1035789
TI  - [Emmonsia crescencse Emmons et Jellison, 1960- a common cause of adiaspiromycosis
      in squirrels (Sciurus vulgaris L.) in Czechoslovakia].

PMID- 1035790
TI  - Regional brain variations of tryptophan, monoamines, monoamine oxidase activity,
      plasma free and total tryptophan during the estrous cycle of the rat.
AB  - Normal 4-day cyclic rats were sacrificed at 10 a.m. and 3 p.m. on proestrus or
      estrus and at 10 a.m. on metestrus. Noradrenaline (NA), dopamine (DA) and
      tryptophan (T) concentrations varied only slightly. Serotonin (5-HT)
      concentrations showed characteristic changing patterns in many hypothalamic,
      limbic and midbrain structures with a decrease during proestrus and an increase
      during estrus being observed. Monoamine oxidase (MAO) activity changes were often
      parallel to the 5-HT changes, but were not as great. The marked changes in 5-HT
      early in proestrus are a further indication of its inhibitory effect on
      gonadotropin release mechanisms before the 'critical period'.

PMID- 1035791
TI  - Persistent estrus in rats after anterolateral hypothalamic microinjections of 6
      hydroxydopamine.
AB  - Bilateral injections of 30 mug of 6-hydroxydopamine (6-OHDA, as base) into the
      anterolateral hypothalamic area induced constant vaginal cornification (CVC),
      polyfollicular ovaries and uterine hypertrophy in cyclic adult female rats. There
      were no important changes in the vaginal patterns or ovarian and uterine
      morphology in animals given injections in the same area with the solvent only and
      in animals given injections with 6-OHDA in the anterior amygdaloid area. It is
      suggested that the persistent estrus after anterolateral hypothalamic injections
      of 6-OHDA results from lesions of central catecholaminergic pathways, which are
      probably involved in gonadotropin secretion.

PMID- 1035792
TI  - [Study of the hypothalamus of neonatally castrated rats by the karyometric
      method].
AB  - The sensitivity of different hypothalamic regions to the effect of androgens has
      been studied during the period of the brain sex differentiation. The castration
      of animals during the first week of life was shown to result in the marked
      increase of size of the neuron nuclei in the preoptic, suprachiasmatic, arcuate
      and ventromedial nuclei of the hypothalamus; the size of neuron nuclei in the
      dorsomedial nucleus suffered no changes. The dynamics of size of the cell nuclei
      was followed in different hypothalamic regions with respect to the time of
      castration.

PMID- 1035793
TI  - [Effect of incomplete starvation on development of compensatory testicular
      hypertrophy during postnatal ontogenesis of rats].
AB  - The incomplete starvation of rats during the first month of life resulted in the
      inhibition of development of the spermatogenic epithelium cells in 80% of
      seminiferous tubules, preserved the increased permeability of hematotesticular
      barrier with respect to rivanol and the ability of rats to react by the increase
      of testis volume in response to unilateral castration. The data obtained confirm
      our hypothesis according to which there is a definite correlation between the
      degree of spermatogenesis completion, the function of hematotesticular barrier
      and the ability of animals for compensatory hypertrophy of testis.

PMID- 1035794
TI  - [Absorption of testosterone-7alpha-3H by reproductive tract tissues of male
      embryo rats in vitro].
AB  - The dynamics of testosterone-7alpha-3H consumption by the reproductive tract
      rudiments (tubules, urogenital sinus and genital tubercle) and the muscles has
      been studied in the in vitro experiments immediately after the isolation of
      embryos (16-21 days of development), as well as after the preliminary two days
      cultivation in the diffusion chambers (13-20 days of development). In the first
      series of experiments, the selective, specific consumption of the labelled
      androgen was observed at all stages under study, whereas in the second series of
      experiments the specific and selective consumption in the organs-targets was
      noted from the 15th day of development (in the genital tubercle and urogenital
      sinus). No selective consumption in the tubules was noted.

PMID- 1035795
TI  - [Synthesis of nucleic acids and proteins in the appendix of chickens infected
      with Eimeria tenella].
AB  - A comparative study was carried out of the synthesis of DNA, RNA and protein in
      blind appendages of the intestine of healthy and infected with E. tenella
      chickens. It was established that the inclusion of P32 into DNA and C14 - orotic
      acid into RNA increases in 2-10 days after the infection. An intensive inclusion
      of C14-lysine into protein of blind appendages was observed in 2-6 days after the
      infection of chickens. Under the effect of the parasite an activation of
      metabolism of DNA, RNA and protein takes place in blind appendages of the host's
      intestine.

PMID- 1035796
TI  - [Bioelectric and etiologic correlates of a model of "anticipation stress"].

PMID- 1035797
TI  - [Thanatophoric nanism[].

PMID- 1035798
TI  - [Screening on aminoacid opathies in newborn infants].

PMID- 1035799
TI  - [Current aspects in the treatment of cardiae arrhythmias in infancy].

PMID- 1035800
TI  - [Bioelectrical activity of the brain in patients with the syndrome of persistent
      galactorrhea-amenorrhea].

PMID- 1035801
TI  - [Familial form of post-pubertal adrenogenital syndrome complicated by sterility].

PMID- 1035802
TI  - Effects of imipramine, chlorimipramine, and fluoxetine on cataplexy in dogs.
AB  - Four narcoleptic dogs with cataplexy were given trials with the serotonin uptake
      blockers imipramine and chlorimipramine (known to be effective in treating
      cataplexy in humans). An even more selective serotonin uptake blocker,
      fluoxetine, was also tested. Injections of placebo, test compound, and placebo
      were given respectively on 3 successive days. Anticataplectic effects were
      measured approximately 30 min, 3 hr, and 6 hr postinjection by recording elapsed
      time and number of cataplectic episodes during the dogs' attempts to eat ten
      pieces of a desired food presented in a standard fashion. Imipramine (1 mg/kg)
      and fluoxetine (1.5 and 3.0 mg/kg)significantly improved performance, while
      chlorimipramine (0.5-5 mg/kg) had no clear effect. Data were not totally
      consistent with the notion that serotonin uptake blockers improve cataplexy in
      dogs, since chlorimipramine was not effective in these animals.

PMID- 1035803
TI  - A comparison of withdrawal in rats implanted with different types of morphine
      pellets.
AB  - Time course and duration and physical dependence was investigated in rats
      implanted subcutaneously with 3 different types of morphine (M) pellets. Each was
      formulated according to the method of Gibson and Tingstand [8], but differed in
      surface area and hardness. Animals were maintained for 19 days after implantation
      and physical dependence was assessed every other day. Severity of naloxone (Nx)
      induced withdrawal was quantified by the use of a composite symptom score and
      weight loss. Withdrawal severity was greatest following implantation of a pellet
      (Type C) of large surface area and low hardness rating, and least following
      implantation of a pellet (Type A) of small surface area and high hardness rating.
      Abstinence severity which resulted from implantation of a pellet (Type B) of
      moderate surface area and low hardness rating was intermediate. When 2 pellets
      were implanted the difference between Type C and B was amplified. It was
      concluded that formulation per se was not sufficient for specifying M pellet
      characteristics.

PMID- 1035804
TI  - Blockade of apomorphine's discriminative stimulus properties: relation to
      neuroleptic activity in neuropharmacological and biochemical assays.
AB  - Using a food-reinforced two-lever operant conditioning procedure, rats were
      trained to discriminate 0.16 mg/kg apomorphine from saline. Eight neuroleptics of
      the phenothiazine, butyrophenone or diphenylbutylamine type were investigated for
      thsir ability to antagonize the discriminative stimulus properties of
      apomorphine. The same drugs were also assayed for in vivo antagonism of
      apomorphine-induced stereotyped behavior as well as for in vitro inhibition of
      stereospecific 3-H-haloperidol binding in rat striatal tissue preparations. The
      data are consistent with the hypothesis that apomorphine exerts its
      discriminative stimulus properties by a mechanism similar to that underlying its
      stereotypogenic action. The loci involved in these two phenomena are likely to be
      distinct.

PMID- 1035805
TI  - Diminished reaction to a novel stimulus during amphetamine withdrawal in rats.
AB  - This experiment determined whether reaction to a novel stimulus was diminished in
      a dose-dependent fashion following 8 consecutive days of d-amphetamine
      administration. Thirty-two male rats were injected with saline, 0.5, 2.5, or 5.0
      mg/kg of d-amphetamine (each N = 8). On the ninth day, all animals received
      saline injections and were tested (a) in the presence of a novel stimulus, or (b)
      in the absence of a novel stimulus. Reaction to the novel stimulus varied
      inversely with the dose of d-amphetamine which had been received during the drug
      administration period. This reduction in reaction to the novel stimulus did not
      seem to depend on (a) the level of amphetamine-induced sterotypy at the end of
      the drug administration period (b) general reduction of activity, or (c)
      interference by drug-conditioned responses.

PMID- 1035806
TI  - Chelatometric determination of epicillin.

PMID- 1035807
TI  - [Comparison of the essential oils of three juniper taxa of the oxycedrus
      section].

PMID- 1035808
TI  - [The genus Chorioptes gervais,1895, parasite of ruminants in Brazil (Psoroptidae,
      Acarina)].

PMID- 1035809
TI  - [Acute renal failure: an experience with 115 patients (author's transl)].

PMID- 1035810
TI  - [Kinetic studies of platelets labeled with 51Cr (author's transl)].

PMID- 1035811
TI  - [Post-stress diabetic response (author's transl)].

PMID- 1035812
TI  - [Influence of circadian rhythm on the production of gastric ulcer due to the
      stress of forced immobilization].

PMID- 1035813
TI  - Incidence and significance of precipitating antibodies in occupational and non
      occupational extrinsic non-atopic (type III) asthma (bronchial asthma with
      precipitins).
AB  - Precipitating antibodies against different organic enviromental dusts were
      studied in 37 patients with suggestive symptoms of nonatopic bronchial asthma,
      comparatively with a group of 4 patients with atopic asthma and with a group of
      asymptomatic subjects, exposed to the same organic dusts as the majority of
      patients. Precipitins were found present in over 75% of the sera from patients
      with infectious type non-atopic asthma and were associated with positive
      semidelayed type skin tests as well as with positive bronchial provocation tests
      a few hours after antigen inhalation. No precipitins were found in the sera from
      patients with atopic asthma. Precipitating antibodies were also found but in
      lower percentages (30%) and at lower titers, in clinically asymptomatic subjects
      who were occupationally exposed to the respective antigens. It was demonstrated
      that the presence of precipitins in the sera of patients with bronchial asthma is
      a valuable diagnostic element which confirms the clinical and anamnestic data.
      The pathogenic role of precipitins is not yet clear. It might be related to the
      amount of these precipitins in the serum.

PMID- 1035814
TI  - The effects of some drugs (eserine, atropine, reserpine, niamid) upon the EEG
      manifestations of experimental neurosis in adult cats.

PMID- 1035815
TI  - [Experience with the work of the adolescents' rooms in the Transcarpathian
      region].

PMID- 1035816
TI  - [Phthisio-urological service in Moscow].

PMID- 1035817
TI  - [Change in the quantity of DNA in the cells of an SPEV culture during growth].

PMID- 1035818
TI  - [Respiratory diseases and gastroenterocolitis of young swine].

PMID- 1035819
TI  - [Creative approach].

PMID- 1035820
TI  - [Aerogenic simultaneous vaccination of swine against plague, erysipelas and
      Aujeszky's disease].

PMID- 1035821
TI  - [Prevention of hypomicroelementoses in young pigs].

PMID- 1035822
TI  - [Infectious necrotic hepatitis of sheep].

PMID- 1035823
TI  - [Morphological changes in the caruncles after calving].

PMID- 1035824
TI  - [Behavior of microfilaments in mouse embryo neuroepithelial cells during normal
      and experimentally disturbed neural tube closure].

PMID- 1035825
TI  - [Scanning electron microscopy of rat ovary surface before, during and after
      ovulation].

PMID- 1035826
TI  - [Functional morphology of endosalpinx and endometrial epithelium].

PMID- 1035827
TI  - [Ultrastructural localization of non-specific carboxylester hydrolase in
      prepubertal and adult mouse testis].

PMID- 1035828
TI  - [Ammonia inhibition of protein degradation in isolated rat hepatocytes:
      quantitative alterations in the lysosomal system (author's transl)].

PMID- 1035829
TI  - Ea rosette test for identification of FC receptor lymphocytes. I. Some technical
      variables.

PMID- 1035830
TI  - Some aspects of the kinetics of emiocytosis in prolactin cells.
AB  - Some aspects of the kinetics of emiocytosis of secretory granules were
      investigated in pituitary prolactin cells of lactating female rats. Most of the
      emiocytotic events were directed towards those areas of the cells which were
      covered with a basal lamina. Diameters of the secretory granules within the
      emiocytotic pockets and of the openings of the pockets to the exterior were
      measured. An inverse relationship between the size of the granule and the
      diameter of the foramen was noted. A mechanism is proposed relative to the
      processes involved in the release of secretory granules from prolactin cells.

PMID- 1035831
TI  - [Effect of an electrostatic field on the synthesis of antibodies].

PMID- 1035832
TI  - Platelet storage in the spleen in idiopathic thrombocytopenic purpura and
      congestive splenomegaly.
AB  - The kinetics of 51Cr-tagged platelets was studied in 10 patients with idiopathic
      thrombocytopenic purpura and in 8 patients with congestive splenomegaly. The
      surgically removed spleens were examined for their platelet content and for their
      microscopic structure. In idiopathic thrombocytopenic purpura the life-span of
      platelets was reduced, the number of platelets washed out from the spleen
      averaged 4.36 X 10(10)/100 g splenic tissue (intrasplenic platelet reserve). The
      index platelets per g splenic tissue/platelets per ml whole blood reflecting the
      tendency of platelets to concentrate in the spleen was 8.06. Microscopically,
      extensive phagocytosis of platelets by macrophages and a preserved lienal
      architecture were seen. In the group of congestive splenomegaly the life-span of
      platelets was not significantly shortened and the intrasplenic platelet reserve
      agreed with the figure found in idiopathic thrombocytopenic purpura. The spleen
      was characterized by fibroid degeneration and endothelial hypertrophy causing
      partial obstruction of the sinusoids. It is concluded that while the intrasplenic
      platelet reserve is nearly the same in idiopathic thrombocytopenic purpura and
      congestive splenomegaly, in idiopathic thrombocytopenic purpura
      hypersequestration while in congestive splenomegaly platelet storage
      predominates.

PMID- 1035834
TI  - The evaluation of hospital medical staff performance--does health care review
      help?

PMID- 1035833
TI  - [Headache].
AB  - Headache is an alarm sympton, whether there is an organic disease (lesional
      headache) or a perturbation of one of the various functions of the head
      (functional headache). Lesional headaches follow a sinusitis or an arthrosis, or
      accompany a "temporal arteritis of Horton". Funstional headaches include several
      varieties. 1. Trigemellar neuralgia. 2.Vascular algi originating from the basal
      arteries, the large cerebral venous sinuses or the branches of the external
      carotid. Among these are: a) headaches due to a dilatation of the internal wall,
      causing "Horton headache", migraine-like psychosomatic migraine and hormonal
      migraines (premenstrual, menstrual, menopausal or linked to the use of
      contraceptive pills); b) headaches caused by an angiospasm of the arteriole,
      which is the case in exposure to the cold, in traumatic headaches (malfunction of
      temporomandibular articulation, dry alveolitis), in psychosomatic angiospastic
      algias and in ethmoidal artery algias preciously described by the author in 1949
      (Godin's disease).3. Headaches due to psychic hypertension. 4. Postconcussional
      psychogenic headaches. 5. Neurotic headaches. The author gives a detailed
      description of the subjective symptoms in each case, including localisation,
      from, intensity, duration course and associated phenomenons. This facilitates
      greatly the differential diagnosis and the choice of complementary examinations.
      Necessary biological investigations should be performed (e.g. hormonal balance).
      One should however avoid to increase the number of complementary examination
      which would only delay treatement and would expose patients to somatisation.
      Furthermore, in each case drug treatment, periarterial infiltration technics of
      the temporal, internal frontal, facial, mastoid and occipital arteries are
      described. The necessity of questioning the patient at lenght and to listen to
      him to enable him to verbalise conscious conflicts is emphasized. A serious
      medicopsychlogical examination and a relaxation treatment to reduce anxiety and
      muscular tension are advised in some cases.

PMID- 1035835
TI  - The development of administrative accountability in health services.

PMID- 1035836
TI  - Distributive versus patient-oriented pharmacy: a pharmacy practice problem
      requiring a definition and solution by pharmacy faculty.

PMID- 1035837
TI  - Clinical aspects of religion as neurosis.

PMID- 1035838
TI  - [Congenital abnormalities in the english-speaking caribbean area].

PMID- 1035839
TI  - The maltase activity of bovine serum as an aid to the study of the amylase i
      locus.
AB  - A method has been described for the detection of maltase activity in starch gels.
      This method has been used to resolve the difficulties encountered when analysing
      animals with weak AmIB activity for Ami genotype. It was found that, with the
      herd of the Hannah Research Institute, the heterozygote excess observed could be
      explained largely on the basis of these weak AmIB bands.

PMID- 1035840
TI  - [Vitamin E activity of stored forages and incidence of myopathy in calves].
AB  - Two experiments to study nutritional muscular dystrophy (N.M.D.) in calves were
      conducted in northern Ontario, where the disease is prevalent. In the first
      experiment, ninety Shorthorn cows were used. They were divided into three groups
      and fed the following forages during the winter of 1972-1973. Group I - Silage.
      Group II. - Heated-air-dried hay. Group III. - Field-dried hay. Chemical analysis
      of the forage during storage showed that the silage had a higher tocopherol
      content than the other two forages. This higher content had a direct effect on
      plasma tocopherol concentrations in the cows, since tocopherol levels were found
      to be higher in the group fed silage than in the other two groups. The highest
      mortality rate-eight dead calves-was in the group fed heated-air-dried hay; one
      calf died in each of the other two groups. Hence, it is evident that the severity
      of N.M.D. symptoms in calves is directly linked with the quantity of selenium or
      vitamin E ingested. The substances act synergistically to protect against the
      disease. In a second experiment, a herd of forty-seven Shorthorn cows, some of
      which had calves with N.N.D. and some of which had healthy offspring, were
      studied to measure the activity of serum creatine phosphokinase. The dams were
      found to have the same C.P.K., whether or not their calves suffered from N.M.D.

PMID- 1035841
TI  - [Abortive infection of mice inoculated intraperitoneally with Chlamydia ovis].
AB  - A mouse adaptated strain of Chlamydia ovis, when inoculated in the peritoneal
      cavity, caused the death of both pregnant and non pregnant mice. In addition,
      mice inoculated late in pregnancy (12 to 16 days after breeding) aborted 4 to 6
      days after inoculation. Chlamydia was recovered from foetuses and from the organs
      of the mice (Liver, Spleen, Lungs). The severity of the disease was related to
      the inoculum concentration, so it was possible to induce late abortions with a
      rapid recovery of the females, like in the natural infection of the ewes. In the
      same conditions, the original Chlamydia strain maintained by passage on yolk sac,
      induced only an inapparent disease transmissible to the young mice.

PMID- 1035842
TI  - [Study on the medium normalized velocity of circumferential lengthening of the
      fiber using ultrasound. I. Evaluation of left-ventricular compliance].
AB  - The following parameters obtained by echocardiography have been measured in a
      group of normal subjects and in a group suffering from hypertrophic subaortic
      stenosis (IHSS): 1) speed of mitral valve protodiastolic closing (MVV); 2)
      circumferential lengthening speed of the fibre (MVCL) both standardized and
      otherwise. There is a good correlation between MVCL and MVV (P = 0.01 and 0.05).
      Since a low mitral valve closing rate is an indirect index for measuring
      ventricular compliance, the use of the MVCL can be considered valid for the same
      purposes. Using this it has in fact been possible to distinguish subjects with
      IHSS in which lower MVV is an index of reduced compliance, from normal subjects.

PMID- 1035843
TI  - [Study on the medium normalized velocity of circumferential lengthening of the
      fiber using ultrasound. II. Use of the construction of left-ventricle performance
      curves].
AB  - Telediastolic pressure and volume can readily be employed as expressions of
      sarcomere length when constructing ventricular performance curves for the normal
      heart. In pathological hearts, however, these parameters are rendered inadequate
      as a result of altered compliance, which means that diastolic lengthening of the
      muscle fibre cell must be determined from telediastolic stress and linear
      compliance, corrected for wall thickness (muscle fibre stretch, strain index).
      Ventricular performance curves were constructed for normal subjects and patients
      with hypertrophic subaortic stenosis, using the normalised mean rate of
      circumferential lengthening of the fibre as the expression of fiber strength.
      Comparison was made with the mean circumferential shortening rate and the
      ejection fraction as the expression of ventricular effort. It was found that both
      normal subjects and stenosis patients lay on the same curve, the latter acting
      low down through having short sarcomeres.

PMID- 1035844
TI  - [Experimental studies on the autoregulation of regional pancreatic circulation.
      Effect of intramural peripheral venous stimulation. 2. Influence of hydergine].

PMID- 1035845
TI  - [Development of the blood vessel network in the chick embryo optic lobes].

PMID- 1035846
TI  - [Diagnosis of the type of twinship (dizygotic, monozygotic) by dermatoglyphic
      studies].

PMID- 1035847
TI  - [Study of hydrolysis of aminoalcohol ethers, phenol and choline under the action
      of horse blood serum cholinesterase].
AB  - Hydrolysis of ethers of saturated and unsaturated alcohols and ethers, e.g.
      phenol and choline, under the action of horse blood serum cholinesterase, was
      studied. The reactivity towards enzymatic hydrolysis is decreased due to a
      greater length of the chain in the alcohol residue of the benzoic acid
      aminoethers; at nCH2 = 4 the compound is a poor substrate. An increase in
      nydrophobicity of the acyl residue of the ether molecule also leads to a decrease
      in the Vmax and Km values. In case of cholinesterase substrates, an increase in
      the molecule hydrophobicity results in an increase of its non-productive
      absorption on the active surface of the enzyme, which decreases its hydrolysis.
      Aminobutynol benzoates are hydrolyzed by cholinesterase more rapidly as compared
      to the ethers of corresponding aminobutanols and their homologs.

PMID- 1035848
TI  - [Changes in subfraction composition of chicken lysine-rich histone during
      ontogenesis].
AB  - Lysine-rich histone isolated from different chicken tissues was separated
      electrophoretically into 4-5 subfractions. The subfrations reffered to as 1, 2,
      3, and 4, occur in each the tissue studied, erythrocyte lysine-rich histone
      containing an additional subfraction 1a. F1 histone from mitotically active
      tissues (intestinal mucosa, thymus, testes) has a higher content of subfraction
      2, while the same histones from mototically inactive tissues (liver, heart,
      brain) contain an elevated amount of subfraction 3. F1 histone isolated from
      liver, brain and heart of 21-day embryo has much more of subfraction 2, than the
      same histone of adult animal. During the chicken development from hatching till
      maturation the content of subfraction 2 in these organs decreases, and the
      content of subfraction 3 increases. The rate of this change in liver corresponds
      to the rate of DNA synthesis. In F1 histone of erythrocytes the content of
      subfraction 4 falls down during the post hatching ontogenesis.

PMID- 1035849
TI  - [DNA-dependent RNA-polymerase activity of isolated kinetoplasts of crithidia
      oncopelti].
AB  - DNA-dependent RNA-polymerase activity was found in the kinetoplasts of Crithidia
      oncopelti. Kinetic patterns of 14C-UTP incorporation into the acid-insoluble
      fraction of isolated kinetoplasts at 25 degrees, 30 degrees and 35 degrees C were
      estimated. The effects of different antibiotics and intercalating agents on RNA
      synthesis in kinetoplasts were studied. alpha-amanitin, a specific inhibitor of
      the nuclear enzyme, does not affect the RNA-polymerase activity of the
      kinetoplasts. Streptolidigin and rifampicin, inhibitors of bacterial RNA
      polymerase, have little effect on RNA synthesis in the kinetoplasts even at high
      concentrations. Kinetoplasts preincubation in the phosphate buffer increases the
      permeability of their membranes for rifampicin. Intercalating agents, acriflavin
      and ethidium bromide, strongly inhibit the kinetoplast RNA synthesis. Similar
      specific effects of some antibiotics and intercalating agents on RNA synthesis in
      kinetoplasts and typical mitochondria may be indicative of similarity of
      functional properties of RNA-polymerases in those organelles.

PMID- 1035850
TI  - Assignment of the gene for beta-glucuronidase (beta-GUS) to chromosome 7 in man.

PMID- 1035851
TI  - Report of the committee on the genetic constitution of autosomes other than
      chromosomes 1,2 and 6.

PMID- 1035852
TI  - The Kotte community health project-- an analysis of data concerning child health
      and suggestions on a new method of record keeping.

PMID- 1035853
TI  - The first record of Bertiella studeri infection in a child from Sri Lanka.

PMID- 1035854
TI  - [Technic of pan-retinal photocoagulation by argon laser in diabetic retinopathy].

PMID- 1035855
TI  - [A recent case of keratoconus in univitelline twins].

PMID- 1035856
TI  - Effect of bee venom components on immuno-competent cell proliferation at a
      primary humoral immune response.

PMID- 1035857
TI  - [Structural changes in caudate nucleus neurons of the progeny of rats subjected
      to exposure to aminazine].
AB  - The caudate nucleus neurons structure in 21-day old rattlings, whose mothers
      received chlorpromazine over the whole period of their pregnancy, was studied.
      The intracellular build-up of the caudate nucleus neurons, the structure of their
      dendrites and spinae were in these rattlings more perfect than in control
      animals. The data obtained accord well with the results of physiological
      observations over the activation of behavioral reactions in the test rattlings as
      against the control ones.

PMID- 1035858
TI  - [Effect of corazole on the functional activity of the caudate nucleus].
AB  - In chronic experiments with freely moving cats the action of diverse metrazol
      doses on the d,1-amphetamine-induced stereotype behaviour and the arrest reaction
      following low frequency stimulation of the caudate nucleus was studied. After
      injections of metrazol (20--30 mg/kg, i.c.) myoclonic seizure jerks and decreased
      locomotion occurred. This state was accompanied by depression of the stereotype
      behaviour and lowered arrest reaction threshold. It is suggested that some
      behavioural and the EEG metrazol-induced changes may come as a result of the
      caudate nucleus activation.

PMID- 1035859
TI  - [Effect of vincamine, vinervine and serotonin on the sexual cycle in rats].
AB  - With a prolonged enteral introduction indole alkaloids vincamine (5--20 mg/kg),
      vinervine (5 mg/kg) and serotonin (2 mg/kg) significantly lengthen the duration
      of the sex cycle through extending the estrus cycle (vincamine, vinervine and
      serotonin) and diestrus (serotonin). Without changing the weight of the uterus
      the studied alkaloids tend to significantly increase the weight of the ovaries
      and the number of follicles therein. In test with sexually mature castrated and
      also sexually immature (both alkaloids) and hypophysectomized (vincamine) animals
      these alkaloids fail to display any estrogenic action.

PMID- 1035860
TI  - [Relationship between the immunodepressant action of methotrexate and the dose of
      antigen].

PMID- 1035861
TI  - New applications of fluidic technology.

PMID- 1035862
TI  - The role of fluidics in medicine.

PMID- 1035863
TI  - The use of fluidic logic valves in emergency resuscitation apparatus.

PMID- 1035864
TI  - Reliability and medical equipment.

PMID- 1035865
TI  - Quantitative reliability techniques--an aid to better medical equipment design.

PMID- 1035866
TI  - A prototype instrument for monitoring muscular effort.

PMID- 1035867
TI  - The development of high tensile properties in a wrought Co-Cr-Ni-W alloy of
      potential orthopaedic surgery use.

PMID- 1035868
TI  - Work hardening characteristics of titanium T 160.

PMID- 1035869
TI  - Ultrastructure of the wall and of the septal pore apparatus in Panaeolus
      foenisecii (Fr.) Kuhn.
AB  - The fine structure of the walls and septal pore apparatus in Panaeolus foenisecii
      is reported. Our description is based on sections of intact hyphae and purified
      fractions, as well as on the analysis of wall surfaces after purification and
      shadowcasting, or else of collapsed hypha walls. The cell wall can be more or
      less homologized to that of the mycelia of Schizophyllum commune; the septal
      apparatus fits the Polyporus model type.

PMID- 1035870
TI  - Enhancement of tumour growth by pretreatment with tumoral cells adsorbed by poly
      i:c deae-dextran complex in syngeneic mice.
AB  - Pretreatment of balb/c mice with ADK-1t cells adsorbed with Poly I:C DEAE- dx
      complex was found to enhance tumour growth as measured after challenge with non
      adsorbed ADK-1t cells. This results contrasts strongly with the increased tumour
      resistance previously observed when Poly I:C alone was used for adsorption. Some
      reasons are suggested for this striking difference.

PMID- 1035871
TI  - Serum 5-nucleotidase in some rachitic and jaundiced Egyptian children.
AB  - 5-Nucleotidase (5-Nase) was determined in the serum of 67 Egyptian Children: 15
      cases as a control group, 10 cases with infantile rickets, 8 cases with the so
      called physiological jaundice of the newborn, 4 cases with rhesus
      incompatibility, and 30 cases with infective hepatits. In rachitic cases and in
      cases with icterus neonatorum, 5-Nase was not increased, while in cases with
      infective hepatitis it showed a statistically significant elevation when compared
      with the control group.

PMID- 1035872
TI  - [An unusual case of simultaneous growth of disgerminoma and teratogenic
      chorionepithelioma of the ovary].

PMID- 1035873
TI  - [Precocious ovarian exhaustion].

PMID- 1035874
TI  - [Local anesthesia and episiotomy].

PMID- 1035875
TI  - [Medicamentous modification of the urethral occlusion in instrument-determined
      stress incontinence in women].

PMID- 1035876
TI  - [Theraupeutic intra-amniotic, transabdominal induction of abortion in the 2nd
      trimenon using prostaglandin F 2alpha].

PMID- 1035877
TI  - [Significance of Green's lateral cystourethrogram for the surgical indication in
      stress incontinence].

PMID- 1035878
TI  - [Vaginal plasty using the Kelly-Stoeckel bladder-neck seam with simultaneous
      vaginal hysterectomy for the treatment of 2nd-degree stress incontinence].

PMID- 1035879
TI  - [Therapy with antibiotics during lactation].

PMID- 1035880
TI  - [Spectrum of serious infections in our obstetric--gynecological patients (1972
      till end of March 1976)].

PMID- 1035881
TI  - [Registration of hypoxia during labor].

PMID- 1035882
TI  - [Intra-uterine resuscitation].

PMID- 1035883
TI  - [Perinatal hypoxia].

PMID- 1035884
TI  - [Neonatal asphyxia without intrauterine and neonatal acidosis. Analysis].

PMID- 1035885
TI  - [Intra-uterine resuscitation by means of beta-mimetic substances and evaluation
      of the newborn infant].

PMID- 1035886
TI  - [Usefulness of monitoring of fetal biophysics during cesarean section].

PMID- 1035887
TI  - [Monitoring of newborn infants at risk in the maternity ward].

PMID- 1035888
TI  - [Infections in obstetrics and gynecology. Introduction].

PMID- 1035889
TI  - [Obstetrical infections].

PMID- 1035890
TI  - [Infections in gynecology].

PMID- 1035891
TI  - [Gramnegative sepsis].

PMID- 1035892
TI  - [Current problem bacteria].

PMID- 1035893
TI  - [Hospitalism from the clinician's point of view].

PMID- 1035894
TI  - [Hospitalism from the view point of the hospital hygienist].

PMID- 1035895
TI  - [Cerclages and infections].

PMID- 1035896
TI  - [Infection morbidity during general intensive monitoring sub partu].

PMID- 1035897
TI  - [Infection morbidity after cesarean section at the University Gynecologic Clinic
      Bern].

PMID- 1035899
TI  - Metal ion requirement of goat carboxypeptidase B.

PMID- 1035898
TI  - Conditions affecting primary cell cultures of functional adult rat hepatocytes.
      II. Dexamethasone enhanced longevity and maintenance of morphology.
AB  - Primary monolayer cell cultures of adult rat hepatocytes underwent change in
      morphology and substantial cell loss between 1 and 3 days postinoculation.
      Dexamethasone-supplementation (1 micronM) of the culture medium maintained the
      polygonal epithelial morphology of the hepatocytes and increased longevity such
      that over 80% of the cells survived for 3 days and at least 30% for 8 or 9 days.
      This enhancement of survival was obtained up to 48 hr postinoculation, but the
      earlier the time of dexamethason supplementation the greater the effect. Removal
      of dexamethasone resulted in a decrease in longevity. The positive effect of
      dexamethasone on longevity was observed following dexamethasone replacement of
      insulin in supplemented cultures, but the combination of insulin and
      dexamethasone resulted in poorer survival than with dexamethasone alone. The
      results are interpreted to indicate that dexamethasone provided a requirement of
      the in vitro environment for survival and suggest that elaboration of a complex
      medium is required to maintain hepatocytes in culture.

PMID- 1035900
TI  - Binding of Zn(II) & Cu(II) by rat liver transfer and ribosomal ribonucleic acids.

PMID- 1035901
TI  - Lack of immunological cross-reaction between cell-wall & one of the cytosol
      hydroxyproline fractions in the leaves of sandal (Santalum album L.).

PMID- 1035902
TI  - Ultrastructure of clear zones exhibiting cytoplasmic incompatibility following
      somatic cell fusion in the myxomycete Didymium iridis.

PMID- 1035903
TI  - Enzymic constitution, ribitol formation & flavinogenesis in Eremothecium ashbyii.

PMID- 1035904
TI  - Effect of Hibiscus rosa sinensis Linn. on oestrous cycle & reproductive organs in
      rats.

PMID- 1035905
TI  - Neonatal ascites with valve in a female urethra (case report with short review of
      literature).

PMID- 1035906
TI  - Depression: psychotherapy or pharmacotherapy.

PMID- 1035907
TI  - Psychoanalysis of severe depression: theory and therapy.

PMID- 1035908
TI  - Hypertrophic obstructive cardiomyopathy prevention of outflow obstruction with
      propranolol.

PMID- 1035909
TI  - Freeze-fracture studies of the thecal membranes of Gonyaulax polyedra: circadian
      changes in the particles of one membrane face.
AB  - Intramembrane faces were visualized in the marine dinoflagellate Gonyaulax
      polyedra by the freeze-fracture technique, in order to test a prediction of a
      membrane model for circadian oscillations--i.e;, that membrane particle
      distribution and size change with time in the circadian cycle. Cells from each of
      four cell suspensions in continuous light (500 1x, 20-21 degrees C) were frozen,
      without fixation or cryoprotection, at four circadian times in a cycle. This
      paper reports findings concerning the membranes associated with the theca,
      particularly the cytoplasmic membrane and the membrane of the large peripheral
      vesicle. While the number and size distribution of the particles of the PF face
      of the cytoplasmic membrane were constant with time, those of the EF face of the
      peripheral vesicle doubled in number at 18 h circadian time as compared with 06
      h. Particles of the 120-A size class, in particular, were more numerous at 12 and
      18 h circadian time than at 00 and 06 h. While the finding does not provide
      definitive confirmation of the membrane hypothesis for circadian rhythms, it is
      consistent with this model. It is suggested that the peripheral vesicle may be
      the site of bioluminescence in Gonyaulax.

PMID- 1035910
TI  - Effect of thiol-oxidation of glutathione with diamide on corneal endothelial
      function, junctional complexes, and microfilaments.
AB  - Intracellular-reduced glutathione (GSH) was removed by thiol-oxidation with
      diamide during in vitro perfusion of the corneal endothelium. By 15 min the
      normal mosaic-like pattern of the endothelial cells was disrupted by serpentine
      like lines of cell separation at the cell juntions. After 45 min of perfusion,
      infividual clusters of cells formed cup-shaped islands. The resultant exposure of
      Descemet's membrane to the perfusion solution resulted in corneal swelling.
      Transmission electron microscopy revealed that the endothelial cells separated at
      the apical junctions and that the microfilaments in the apical cytoplasm of cells
      formed dense bands, whereas the other subcellular organelles were normal in
      appearance. The change in cellular shape may be due to loss of cellular adhesion
      which results in the condensation of the microfilaments or contraction of the
      microfilaments. The addition of glucose to the perfusate prevented the diamide
      effect, and the diamide effect could be reversed upon removal and perfusion of a
      glutathione bicarbonate Ringer's solution. These results suggest that the ratio
      of reduced to oxidized glutathione in the endothelial cells plays a role in the
      maintenance of the endothelial cell barrier function.

PMID- 1035911
TI  - Interactions of actin, myosin, and a new actin-binding protein of rabbit
      pulmonary macrophages. II. Role in cytoplasmic movement and phagocytosis.
AB  - Actin and myosin of rabbit pulmonary macrophages are influenced by two other
      proteins. A protein cofactor is required for the actin activation of macrophage
      myosin Mg2 ATPase activity, and a high molecular weight actin-binding protein
      aggregates actin filaments (Stossel T.P., and J.H. Hartwig. 1975. J. Biol. Chem.
      250:5706-5711)9 When warmed in 0.34 M sucrose solution containing Mg2-ATP and
      dithiothreitol, these four proteins interact cooperatively. Acin-binding protein
      in the presence of actin causes the actin to form a gel, which liquifies when
      cooled. The myosin contracts the gel into an aggregate, and the rate of
      aggregation is accelerated by the cofactor. Therefore, we believe that these four
      proteins also effec the temperature-dependent gelation and aggregation of crude
      sucrose extracts pulmonary macrophages containing Mg2-ATP and dithiothreitol. The
      gelled extracts are composed of tangled filaments. Relative to homogenates of
      resting macrophages, the distribution of actin-binding protein in homogenates of
      phagocytizing macrophages is altered such that 2-6 times more actin-binding
      protein is soluble. Sucrose extracts of phagocytizing macrophages gel more
      rapidly than extracts of resting macrophages. Phagocytosis by pulmonary
      macrophages involves the formation of peripheral pseudopods containing filaments.
      The findings suggest that the actin-binding protein initiates a cooperative
      interaction of contractile proteins to generate cytoplasmic gelation, and that
      phagocytosis influences the behavior of the actin-binding protein.

PMID- 1035912
TI  - Ultrastructural features of chromatin nu bodies.
AB  - Spread chromatin fibers and isolated chromatin fragments prepared from chicken
      erythrocyte nuclei were stained with dilute aqueous uranyl acetate. High
      resolution electron micrographs reveal two new morphological features exhibited
      by many of the chromatin nu bodies: (a) lateral association of the nu body with
      the connecting strand, and (b) a centrally stained spot approximately 15 A wide,
      possibly corresponding to a hole or crevice within the nu body.

PMID- 1035913
TI  - [Oxidation of normal primary alcohols by Torulopsis candida cells and
      mitochondria].

PMID- 1035914
TI  - [Change in the physiological and biochemical properties, enzymatic activity and
      intracellular structures of the mother cells and buds of Candida utilis IBFM-405
      yeast in the process of their growth and development].

PMID- 1035915
TI  - Mechanical damage to rabbit tracheal epithelium from inhaling inert pyrite dust
      of needle-like structure. Part II.
AB  - The ultrastructure of rabbit tracheal epithelium was studied 2, 8 and 26 hours
      after termination of 8-hour inhalation of ground pyrite dust. Pyrite particles
      persist in the cytoplasm of ciliated cells throughout the interval followed up.
      Only through degeneration and elimination of these cells from the epithelium is
      the inhaled dust gradually removed from the mucous membrane. Goblet cells
      discharge pyrite-containing  mucus into the  ciliary border region for a period
      of 26 hours after cessation of inhalation thus inducing further damage to the
      ciliary border and the apical regions of the cells even after termination of
      inhalation. The morphological appearance of the ciliary border, especially in the
      first phase after termination of inhalation, suggests a disturbance of the self
      cleaning function of the eipithelium of respiratory passages. The inhalation of
      aerosol of needle-like structure causes mechanical damage to tracheal epithelium.
      Substantial retardation of the onset of epithelial regeneration and slow rate of
      elimination of the inhaled aerosol from the tracheal mucosa was noted.

PMID- 1035916
TI  - Distribution and elimination of tin taken up into the organism in the form of
      organo-tin compounds.

PMID- 1035917
TI  - [Evaluation of the incidence of congenital rubella in GDR].
AB  - Annual number of congenital rubellas in GDR was evaluated by means of a
      mathematic model. Dates of inmunity rate of rubella in L. and P. districts
      obtained by means of haemagglutination inhibition reaction were taken into
      account. From these dates of a number of possible primary cases of rubella
      infection in wifes in the first 3 months of pregnancy as well as literary dates
      on mean number of monsters determined after the infection, i.e. 10--15--25%
      cases, were evaluated. There were obtained in relation with different mean
      numbers of monsters 37--56--93 cases of congenital rubellas for live born
      children from mothers at the age of 14 to 45 years. It results in total that the
      incidence of disease for live born children from mothers up to 45 years, is 0,2-
      0,5%, i.e. 2--5 children with congenital rubella on 10 000 live born children.
      Compared with literary data, it results a good correlation between proper
      evaluations and numbers of congenital rubella incidence quoted by other authors.
      In view of these evaluations, a conclusion to introduce protective rubella
      vaccination, is fully justified.

PMID- 1035918
TI  - International and national aspects of epidemiological plague surveillance in the
      USSR.
AB  - General principles and organizational forms of epidemiological surveillance of
      plague in the USSR both in seaports andin natural foci are discussed. On the
      basis of the analysis of the authors' experience over many years and taking into
      consideration literary data, the authors recommend a minimum, but in their
      opinion effective amount of a successful realization of these recommendations, it
      is expedient to establish a special team (or teams) consisting of 10-12 members.

PMID- 1035919
TI  - The epidemiology of epidemic parotitis in the USSR.
AB  - Morbidity from epidemic parotitis in the USSR in the period from 1958 to 1972
      ranged within the limits of 266.6 and 521.7 cases per 100 000 inhabitants. A 3--4
      years cyclic recurrence of rises and falls in morbidity was observed. The bulk of
      cases of disease occur in the winter-spring period. In towns, parotitis is
      registered 3 times more frequently, in the mean, than in rural districts. More
      than 95% of patients in the USSR consisted of children under 15, while in Moscow,
      children aged 3--5 years were the most affected group. In Moscow in the period
      from February 1, 1972 to January 31, 1973, the morbidity in men was 493.2 per 100
      000 and in women 339.5 per 100 000 (ratio 1:1.45).

PMID- 1035920
TI  - The density of microflora in the oral and pharyngeal cavities.
AB  - A method for quantitative assessment of the microbial density on the mucous
      membranes in the oral and pharyngeal cavities is described. The results of the
      assessment are in agreement with the theoretical assumption based on the
      existence of a natural electrostatic filter. The highest density of microbes is
      on the tonsils where the positive pole of the filter is situated, so that a
      synergism between the defensive immunological role of the tonsils and the
      bioelectric potential pattern is obvious. The microbial densities in the oral
      cavity are more or less interdependent whereas the findings on the pharynx rear
      wall are isolated being probably perturbed by repeated swallowing.

PMID- 1035921
TI  - Identification of Leptospira andamana isolated from the spinal fluid of a fatal
      case of leptospirosis in Sao Paulo, 1963.
AB  - The IAL-S. P. strain was isolated from the spinal fluid of a patient male, aged
      35, black, a sewer worker with fever, myalgia, jaundice, vomiting and meningitis
      symptoms with a 5-day incubation period after the lower half of the body had been
      submerged for 2 hours in sewers when unblocking a drain. Leptospires were
      isolated by direct inoculation of the spinal fluid taken on the 9th day of the
      illness into the Fletcher's media and into guinea pigs by the intraperitoneal
      route. The patient gave a positive agglutination test for L. andamana with cross
      reaction with L. sejroe. The strain was identified as L. andamana by the cross
      agglutination-lysis test and the cross-absorption test. The IAL-S. P. strain is
      undoubtedly not saprophytic but parasitic and pathogenic for man and animals,
      however its biological properties resist to the oligodynamic action of Cu and Hg
      and the 8-azoguanine action as in the case of the Patoc 1 strain. I could be
      recommended to reconsider whether the strain belongs to L. interrogans, L.
      biflexa or to another group because the grounds for L. andamana being saprophytic
      were denied by this report.

PMID- 1035922
TI  - Composition of immunoglobulins in brucellosis patients using DEAE-cellulose
      column chromatography.
AB  - The composition of immunoglobulins in patients with brucellosis was studied. The
      method of ion-exchange chromatography on DEAE-cellulose columns was used to
      define more precisely the physico-chemical character of cysteine-resistant
      antibodies. The study of IgM, IgA and IgG fractions obtained from the patients
      sera showed the IgG fraction to possess the greatest serological activity in the
      agglutination reaction, in the passive haemagglutination reaction and in Coomb's
      test. Specific antibodies in the remaining 2 fractions  (IgA and IgM) were found
      only in single patients in low titres, mainly in Coomb's test (incomplete
      antibodies). The study of IgM, IgA and IgG serum fractions before and after
      cysteine treatment revealed cysteine-resistant antibodies to be usually IgG
      globulins. The presence of specific IgG antibodies in the sera of patients was
      found to correlate with active clinical manifestations of brucellosis.

PMID- 1035923
TI  - Investigation of some problems of virology and creation of means of specific
      prophylaxis of virus infections in the institute of poliomyelitis and virus
      encephalitis, academy of medical sciences of the USSR.
AB  - Several great problems are clearly distinguished in the development of the Soviet
      medical virology. The team of the Institute of Polliomyelitis and Virus
      Encephalitis of the AMS of the USSR actively participates in the study of these
      problems. They include the investigation of theoretical questions of general
      virology, creation and improvement of means of specific prophylaxis of virus
      infections, virological examination of diseases endemic for single districts of
      the USSR as well as the search for, discovery and exploration of new viruses,
      causative agents of disease. The achievements of the team of the Institute of
      Poliomyelitis and Virus Encephalitis in the field of liquidation of poliomyelits,
      creation of new effective preparations against tick-borne encephalitis, rabies
      and other neurovirus infections are a clear consequence of the prophylactic trend
      of the Soviet health care, thoughtful planning of scientific work and broad,
      complex conception of scientific investigations, close connection with other
      scientific institutions, involvement of specialists of contiguous disciplines in
      scientific problems, international cooperation inthe elaboration of the mentioned
      problems within the framework of the CMEA, the use of the most modern and most
      perfect methods of scientific work and the accomplishment of all socio-economic
      and medical measures.

PMID- 1035924
TI  - Administration of antibiotics in combination. Determination of antibacterial
      effectivity of blood serum and urine after simultaneous administration of
      macrolides and tetracyclines.
AB  - The authors deal with antibacterial effectivity of blood serum and urine in
      simultaneous administration of macrolids and tetracyclines under in vivo
      conditions, using Staphylococcus aureus strains. The obtained results suggest
      that pharmacodynamic effect, i.e., higher effective concentration, is induced in
      some combinations of these preparations. It was found mainly after the
      administration of the combinations of erythromycin 250 mg + doxycycline 200 mg in
      all the chosen reference strains S. a. The results have also shown that the
      combination of erythromycin with tetracycline has a higher effect when an
      erythromycin-resistant strain is used than when using a strain resistant to
      tetracycline.

PMID- 1035925
TI  - Leukocyte phosphatase activity during immunization with bacterial vaccines.

PMID- 1035926
TI  - Ophthalmic emergencies and their management.

PMID- 1035927
TI  - [3-dimensional image reconstruction of protein molecules from electron
      micrographs].

PMID- 1035928
TI  - Motility evaluation of bull spermatozoa by photon correlation spectroscopy.
AB  - Quasi-elastic light scattering techniques are employed to evaluate motility of
      bovine spermatozoa. The electric field correlation function CE(k, tau) has two
      components CE(k, tau) = alphafm+(1-alpha)fd, where fm is the correlation function
      due to motile cells, fd is due to dead cells and alpha is the fraction of motile
      cells. A function which is a linear combination of the experimentally measured fd
      and an empirically determined function fm is fit to the CE(k, tau) data. In this
      way, alpha and the approximate analytic form of fm are determined. The
      distribution of swimming speeds P(v) is derived from fm using an inverse Fourier
      sine transform procedure. Results for the time dependence of motility of bull
      sperm in Hank's balanced salt solution are presented.

PMID- 1035929
TI  - Force-length relations of glycerinated rabbit psoas.
AB  - Force-length curves of glycerinated rabbit psoas were determined in media of
      physiological interest. In one set of experiments the free [Ca++] was constant at
      10(-5) M and the [MgATP] varied. At low [MgATP] the elastic properties are those
      of a highly ordered, inextensible fiber; at high [MgATP] they are representative
      of a much more elastic body. At intermediate concentrations sigmoidal shaped
      curves were observed as were also found when [MgATP] was constant and the free
      [Ca++] varied. These curves closely resemble coexistence curves that have been
      reported for fibrous proteins.

PMID- 1035930
TI  - Heavy metals and spermatozoan motility. III conformational changes induced by
      divalent cations and by ATP in flagellar proteins.
AB  - Conformational changes of flagellar proteins of sea urchin spermatozoa caused by
      divalent cations and nucleotides were investigated by examining the circular
      dichroism spectra of axonemes and outer doublet microtubules. The alpha-Helix
      content of the flagellar components was diminished in the presence of zinc,
      cadmium and mercury, while no other heavy metals contributed to such a change.
      The original content of alpha-helix was restored by the subsequent addition of
      ATP or GTP, the former being more effective. An oscillation was found to occur in
      the alpha-helix content measured at 222 micron in the presence of zinc and ATP.
      On the other hand, ATP caused a marked reduction in alpha-helical structures of
      axonemes in the presence of magnesium or calcium, especially in a medium
      containing KCl. The effect was rather specific for ATP. The obtained results were
      discussed in relation to the basic mechanisms of spermatozoan motility.

PMID- 1035931
TI  - [Anodic synthesis of acid parts in capsaicinoids and spectroscopic analysis. II
      (author's transl)].

PMID- 1035932
TI  - [Syntheses of 2-alkylpyrimidines by dehydrogenocyclization of trimethylenediamine
      and aldehydes, and the kinetics (author's transl)].

PMID- 1035933
TI  - [Studies on anti-inflammatory agents. XXXIX; Effects of 2-(5H-[1]benzopyrano-[2,3
      b]pyridin-7-yl)propionic acid (Y-8004) on leucocyte emigration and enzyme release
      from emigrated leucocytes in vivo (author's transl)].

PMID- 1035934
TI  - [Reactive intermediate products in the reaction of p-toluenediazonium sulfate,
      thiocyanate ion and some kinds of metal ions (author's transl)].

PMID- 1035935
TI  - [Fluorometric titration for serum chloride (author's transl)].

PMID- 1035936
TI  - [Syntheses of 1-carboxy-1,2,3,4-tetrahydroisoquinoline derivatives, 6-carboxy
      1,2,3,4,4a,5,6,10b-oxtahydrophenanthridine derivatives and 6-carboxy-dibenzo[b,
      d]pyran derivatives by phenolic cyclization (studies on the syntheses of
      heterocyclic compounds. DCLXIV) (author's transl)].

PMID- 1035937
TI  - [High-speed liquid chromatographic determination of glycyrrhizin in Liquorice
      roots and extracts (author's transl)].

PMID- 1035938
TI  - [Synthesis of N-decanoyl-alpha-and gamma-glutamyl oligopeptide methyl esters
      (author's transl)].

PMID- 1035939
TI  - [Synthesis of Bis(alkoxymethyl) ethers (author's transl)].

PMID- 1035940
TI  - [Studies on the constituents of Apocynaceae plants; Isolation of flavonol
      glycosides and some other components from the leaves of Cerbera manghas L; (1)
      (author's transl)].

PMID- 1035941
TI  - [Studies on anti-inflammatory agents. XXXIII. Isolation and identification of the
      urinary metabolites of 2-(5H-[1]benzopyrano[2,3-b]-pyridin-7-yl)propionic acid (Y
      8004) in mice (author's transl)].

PMID- 1035942
TI  - [Synthesis of yokonoside and its related compounds (author's transl)].

PMID- 1035943
TI  - [Synthesis of pyrrolidine derivatives with pharmacological activity. IX.
      Synthesis of 1,1,5-trimethyl-2-ethyl- and 1,1,2,4,5-pentamethyl-3
      diphenylmethylenepyrrolidinium iodide as potential anticholinergic agents
      (author's transl)].

PMID- 1035944
TI  - [Studies on the constituents of Liliaceae plants. VI; Analysis of aliphatic
      compounds in the leaves, stems, flowers and fruits of Erythronium japonicum Decne
      (author's transl)].

PMID- 1035945
TI  - [Syntheses of oxazolecarboxylic acid derivatives. XII. Hydrogenolysis of
      aminoxazoles. (5). Syntheses of alkenylureas (author's transl)].

PMID- 1035946
TI  - [The reaction of heteroaromatic n-oxide with acid chloride and cyanide. I. On the
      reaction of 2-substituted and 2,3-disubstituted quinoline 1-oxides with aroyl
      chloride and potassium cyanide (author's transl)].

PMID- 1035947
TI  - [The components of the plants of Lagerstroemia genus. III. On the structure of
      the new tannin "lagertannin" from the leaves of Lagerstroemia speciosa (L.) Pers.
      (author's transl)].

PMID- 1035948
TI  - [Reaction of trialkylborane. V. The reaction of amide compounds in the presence
      of trialkylborane (author's transl)].

PMID- 1035949
TI  - [Studies on the synthesis of antispasmodic agent. III. Configuration of
      diastereoisomers of 1-diethylamino-3-hydroxy-2-methylbutane (author's transl)].

PMID- 1035950
TI  - [Pattern stimulation and salivary secretion (author's transl)].
AB  - Experiments were carried out to investigate the effect of temporal stimulus
      pattern of chorda or sympathetic stimulation on salivary secretion of the rabbit
      or the dog. Stimulation of short or long period was adopted. The latency and the
      velocity of secretion were recorded. The amount of secretion increased with the
      increase of the number of stimuli within moderate range. The optimum interval of
      chorda stimulation was about 50 msec, but it was somewhat longer for shorter
      period of stimulation. Various patterns of stimulation were adopted (1) by
      varying the interval, the number of stimuli and the period of stimulation, (2) by
      changing stepwise the interval halfway through stimulation and (3) by
      intermittent stimulation. Experiments on the effect of sympathetic stimulation
      were also reported. Fitness of Michaelis-Menten's equation for the relationship
      between the number of stimuli and the amount of secretion was tested. Moreover,
      the other equation that described this relation satisfactorily was derived from
      the hypothesis of superposition of unitary processes. It is suggested that the
      response of a excitable tissue to repetitive stimuli, if it be pattern sensitive,
      can not be predicted only from the intensity, the frequency and the number of
      stimuli without considering their temporal configuration.

PMID- 1035951
TI  - [The physiologic properties of potential changes elicited in the eyelid by flash
      stimulation (author's transl)].

PMID- 1035952
TI  - Energy requirements of men during exercise in a hot environment and a comfortable
      environment.

PMID- 1035953
TI  - Male pseudoheterosexuality and minimal sexual dysfunction.
AB  - Male heterosexual activity is not always heterosexual. Frequently it only appears
      to be, but, in fact, it is an attempt at denial of underlying homosexual
      feelings. There is often a correlation between such "pseudoheterosexuality" and
      minor sexual dysfunctions. Insight alone is not sufficient to provide relief, but
      when the patient can be helped to a comfortable acceptance of his homosexual
      feelings as a normal and healthy facet of his personality, very often the
      dysfunction is relieved, and there is a marked change in the ability of the
      individual to achieve gratification in genuine heterosexuality.

PMID- 1035954
TI  - Changing attendance patterns to sex therapy programs as a function of location
      and personnel.
AB  - This paper explores innovative treatment modalities that may encourage the
      participation of lower socioeconomic minority clients in sex therapy programs. It
      suggests the consideration of informal therapeutic settings, flexible hours, and
      an immediate contact with the therapist. It lends support to the concept that
      equal time be given to education and communication skills in counseling. It also
      stresses the necessity of directive yet permissive techniques to bridge the
      communication gap by identifying areas of commonality, especially when confronted
      with the lower socioeconomic minority client. The paper compares this approach
      with a sex therapy approach more oriented to the middle class.

PMID- 1035955
TI  - [Clincopathological study of IgA nephropathy].

PMID- 1035956
TI  - [Kidney and fibrinolysis (1) with special reference to systemic fibrindytic
      activities].

PMID- 1035957
TI  - [Alteration of membrane lipid fractions and the life span of the erythrocyte in
      uremia].

PMID- 1035958
TI  - [Plasma renin activity in patients on chronic dialysis].

PMID- 1035959
TI  - [Basis of kidney function tests. (1) Discrimination between cortical and
      medullary functions].

PMID- 1035960
TI  - [Basis of kidney function tests. (2) Reliability of the test results].

PMID- 1035961
TI  - [Basis of kidney function tests. (3) Normal values and aging].

PMID- 1035962
TI  - [Basis of kidney function tests. (4) Correlation between morphological and
      functional changes. (in glomerulonephritis)].

PMID- 1035963
TI  - [Basis of kidney function tests. (5) Applicatoin to diagnosis].

PMID- 1035964
TI  - [Evaluation of the diurnal rhythm of blood coagulation in ischemic heart disease
      by means of the method of geometrical interpretation of the observation results].

PMID- 1035965
TI  - Steroid regulation of sexual behavior.

PMID- 1035966
TI  - [Device for measuring the miction output].
AB  - An apparatus enabling it to register the micturition rate both under natural
      conditions and during catheterization of the urinary bladder is recommended for
      gauging the miction output. The method of measuring the miction (urinary) output
      is very simple. Formulas listed in the paper permit one to calculate the relative
      urethral resistance from the amounts of miction and cetherterized urinary
      outputs.

PMID- 1035967
TI  - [Effectiveness of thiabendazole, mebendazole and mecarzole in the migration stage
      of Nippostrongylus braziliensis in albino mice].

PMID- 1035968
TI  - Inhibition of gonadotropin secretion induced by stimulation of thalamic nuclei.
AB  - The effect of electrochemical stimulation (anodic current, 100 micronA/30 sec) of
      thalamic nuclei was studied in nonanesthetized freely-behaving rats bearing
      chronic implanted electrodes and plastic cannulae inserted into the jugular vein
      for blood sampling. Stimulation of the anterior thalamic nuclei, the nucleus (n.)
      mediodorsalis thalami (MD) and the n. posteromedianus thalami at 2 p.m. on the
      day of proestrus prevented spontaneous ovulation and the release of LH which
      takes place on that day. No effect on ovulation or LH release was observed after
      stimulation of the n. lateralis thalami, the n. ventralis thalami or other
      thalamic nuclei or after passing a cathodic current through the n. MD.
      Stimulation of the n. MD resulted also in a significant decrease of the elevated
      serum LH levels found after an injection of progesterone into ovariectomyzed
      estrogen-primed rats. These results indicate that nuclei of the medial thalamic
      region are capable of inhibiting LH secretion. No stimulatory influence of LH
      release was observed after thalamic stimulation in ovariectomized estrogen
      treated rats.

PMID- 1035969
TI  - Plasma norepinephrine during the rat estrous cycle and after progesterone
      treatment to the ovariectomized estrogen-primed rat.
AB  - In four-day cycling rats studied during the estrous cycle, the levels of
      circulating norepinephrine (NE) showed a sharp rise concomitant with the LH surge
      in the afternoon of proestrus. Following the peak, plasma NE fell rapidly to the
      minimum value by the morning of estrus. The administration of progesterone to
      ovariectomized estrogen-primed rats resulted in a surge in plasma NE levels 4 h
      after progesterone treatment. The maximal levels attained were 3-fold greater
      than baseline values, falling rapidly to reach basal values 8 h after the
      administration of progesterone. The amine levels remained unaffected 12-20 h
      later. The LH values attained a maximum 8 h after the injection of progesterone.
      In rats treated with estradiol benzoate (EB) followed by 0.1 ml of oil instead of
      progesterone, neither the NE nor the LH peak were observed. These findings are
      discussed with respect to the significance of increased amounts of plasma NE
      related to the LH surge.

PMID- 1035971
TI  - [Results of scientific studies conducted at the Central Institute of Hematology
      and Blood Transfusion concerning hematologic surgery].

PMID- 1035972
TI  - Surface differences of normal and transformed cells as detected by a new,
      fluorescent labeling technique.
AB  - A method was developed to label the outer surface of chick embryo fibroblasts
      with fluorescamine. Cells were labeled in less than a minute without disruption
      of the monolayer. Polyacrylamide gel electrophoresis resolved two distinct areas
      of fluorescence: a group of high molecular weight polypeptides and several
      rapidly migrating species. The latter were demonstrated to be phospholipids by
      thin layer chromatography. Fluorescamine did not label internal components of the
      cell, as evidenced by two intracellular proteins which were found to be
      nonfluorescent. Intact normal cells were labeled threefold more than transformed
      cells, indicating a possible loss of reactive sites at the surface.

PMID- 1035973
TI  - Attack-induced changes in response to decapitation of plasma catecholamines of
      victim mice.
AB  - Male mice of 3 different strains (NIH, C57BR/cdJ and A/HeJ) were exposed
      individuality (victims) to attack by trained fighter Swiss Webster mice for 10
      minutes daily for various numbers of days. Immediately after the last attack the
      victim mice were decapitated along with unattacked control mice of the
      appropriate strain, and plasma norepinephrine (NE) and epinephrine (E) were
      measured. The concentration of NE was significantly lower in decapitated
      C57BR/cdJ mice than in the other 2 strains. The concentrations of E and NE in the
      plasma of decapitated C57BR/cdJ and A/HeJ mice were significantly greater after 4
      days of attacks, whereas in NIH mice plasma levels of only NE were greater and
      this occurred only after 14 days of attacks. After 7 days of exposure to attack,
      C57BR/cdJ and A/HeJ victim mice were permitted to rest for various periods of
      time. In C57BR/cdJ animals plasma E returned to almost normal levels after 2
      days, and NE after 4 days, while in A/HeJ mice plasma E and NE returned to
      control levels already after 1 day of rest.

PMID- 1035974
TI  - Comparison of two methods for the determination of catalase activity.

PMID- 1035975
TI  - Variations in immunoglobulin concentrations in Finnish x Dorset Horn lambs.
AB  - The serum immunoglobulin concentrations in two-day-old Finnish x Dorset Horn
      lambs, which were born and nursed indoors, were high and unrelated to littersize,
      except when young ewes had large litters, or when ewes lambed twice in a year.
      The results contrast sharply with those from Merino and Blackface lambs, examined
      previously, whose mean concentrations were much lower, and generally fell
      substantially with increasing litter-size. The superiority of the Finnish x
      Dorset Horn sheep in this respect is attributed to the ability of the lambs to
      suck particularly vigorously, shortly after birth, especially when large litters
      are compared, and to a higher rate of colostrum production by the ewes. The
      correlations between the immunoglobulin concentrations in the lambs and their
      growth and survival were significant but slight.

PMID- 1035976
TI  - Breed differences in the position of the urethral meatus of gilts.
AB  - In a strain of Pietrain the distance between the vulva and the urethral meatus is
      greater than that of other breeds of pig. This difference is such that it is
      difficult to catheterise the bladders of Pietrain gilts since the available
      specula are either too short in length or too wide in diameter.

PMID- 1035977
TI  - DNA metabolism in relation to the differentiation of antibody-producing capacity
      by lymphoid tissues [proceedings].

PMID- 1035978
TI  - Spontaneous release of DNA by living cells [proceedings].

PMID- 1035979
TI  - [Ultrastructural analysis of complexes formed by purified histones
      (proceedings)].

PMID- 1035980
TI  - [Possible uses of radiofrequency spectroscopy (EPR) in the study of the kinetics
      of biological systems (demonstration of manganese in Diphyllobothrium latum eggs)
      (proceedings)].

PMID- 1035981
TI  - [Sex cycle in the chamois (Rupicapra rupicapra)].

PMID- 1035982
TI  - Prevalence and distribution of schistosomiasis in the Philippines: a review.
AB  - The known endemic areas in the Philippines are the provinces of Mindoro Oriental
      and Sorsogon in Southern Luzon; the provinces of North, East and Western Samar;
      Leyte; and Bohol in Eastern Visayas, and all the provinces of Mindanao with the
      exception of Misamis Oriental, Davao Oriental and Maguindanao. The total snail
      area in 22 affected provinces is estimated aorth latitude. There are 655,124
      estimated cases out of 3,961,000 exposed population or a prevalence of 16.5%
      based on the results of stool surveys conducted by Regional Schistosomiasis
      Advisory Teams and projected to the total population in the endemic areas.

PMID- 1035983
TI  - The biology of Schistosoma japonicum, Philippine strain: a review.
AB  - Some important and adequately studied aspects of the biology of Schistosoma
      japonicum in the Philippines were reviewed and presented. The identity of the
      species of human blood fluke in the Philippines was established by Tubangui who
      also was the first to complete the life cycle of the parasite in his laboratory.
      Successful cross-infections of different strains of S. Japonicum from different
      mammalian hosts including man suggest that there is only one common strain for
      all of the definitive hosts in the Philippines. Studies on egg-laying habits,
      factors affecting hatching of eggs, eruption of cercariae from snails, cercarial
      survival and undocumented obervations are considered in this review.

PMID- 1035984
TI  - Current status of research on the biology of Mekong Schistosoma.

PMID- 1035985
TI  - Advances in pathophysiology of schistosomiasis japonica: a review.
AB  - Schistosomiasis is a chronic granulomatous disease caused by a delayed type of
      hypersensitivity reaction to eggs deposited or trapped in the tissues. Granuloma
      formation, depending on extent, if in the liver will lead to portal hypertension
      while if in the lungs, will lead to pulmonary hypertension and cor pulmonale.

PMID- 1035986
TI  - Light microscopy and scanning electron microscopy of Bathmostomum sangeri
      Cobbold, 1879, of elephants.
AB  - Bathmostomum sangeri is an intestinal parasite of the elephant. Males measured
      12.15-14.25 mm in length; females measured 14.98-17.68 mm in length. Buccal
      capsule is well-developed and funnel-shaped. There is a raised and transverse
      fissure ridge around the oral margin. The internal wall of the buccal capsule is
      raised into a series of circular ridges or lamellae. Teeth or cutting plates
      could not be seen. Spicules are stout, wing-like structures. The telamon is pear
      shaped, but a gibernaculum is not present. There are two pairs of papillae on the
      either side of the cloacal opening. The female tail is gradually tepering.

PMID- 1035987
TI  - [Amino acid composition of the serum and urine in a series of children suffering
      from rheumatoid fever].

PMID- 1035988
TI  - [Electron microscopic study of the process of fertilization and zygote formation
      in Oedogonium cardiacum Wittr].

PMID- 1035989
TI  - [Specificity of radiation and chemical mutagenesis in swine at the cellular
      level].

PMID- 1035990
TI  - [Ultrastructure of the centrometric regions of mouse chromosomes in metaphase
      chromosomes and interphase nuclei].
AB  - The chromatin ultrastructure was studied in the centromeric region of mitotic
      chromosomes and in interphase nuclei of mouse cells after differential staining
      on C-band. A new method is suggested to study centromeric region of chromosomes
      treated by the Giemsa banding technique. Fibers of chromosomes appeared to be
      packed denser in the centromeric regions of mitotic chromosomes than in arms. The
      disposition of chromatin fibers in the centromeric chromocentres of interphase
      nuclei is the same as in the centromeric regions of mitotic chromosomes.

PMID- 1035991
TI  - [Effect of acetycholine on the Ca2+ transport system in sarcoplasmic reticulum of
      frog skeletal muscle].
AB  - In fragments of sarcoplasmic reticulum of the frog abdominal straight muscle the
      functional properties of Ca2+ transport and effect of acetycholine on those
      properties were studied. The rate of Ca2+ accumulation was decreased due to
      stimulation by acetylcholine the Ca2+ out-flow from the reticular vesicles. The
      ratio Ca2+/ATP decreased and the Ca2+-ATPase activity was increased. The Ki vlaue
      for the inhibition by acetylcholine of Ca2+ absorption was 60micronM. Effect of
      acetylcholine on the Ca2+ transport depended on the temperature of medium.

PMID- 1035992
TI  - [Phospholipids and free ethanolamine in the brain and liver of albino rats in
      alcoholic intoxication].
AB  - An experimental alcohol intoxication was accompanied by an increase in content of
      total phospholipids and phosphatide acid in rat brain with simultaneous decrease
      in content of free ethanolamine. The phenomenon demonstrate the activation of
      phosphatidogenesis. In the liver tissue an opposite alterations were observed;
      the lipolytic reactions were activated.

PMID- 1035993
TI  - [Activity of various enzymes of the initial stages of glycerolipid biosynthesis
      and glycerophosphate content in alcoholic intoxication].
AB  - A distinct increase in activity of glycerokinase and glycerophosphate
      dehydrogenase and in content of L-alpha-glycerophosphate were observed in brain
      and liver tissues of rats treated with ethanol for 40 days. The similar
      alterations were observed after treatment with ehtanol for 80 days but in these
      conditions the content of L-alpha-glycerophosphate in liver tissue was decreased.

PMID- 1035994
TI  - [Adenylate deaminase of the liver mitochondria in normal state and in alcoholic
      intoxication].
AB  - AMP-deaminases were isolated and partially purified from subfractions of soluble
      mitochondrial proteins of rat liver under normal conditions and in ethanol
      intoxication. Repeated freezing and thawing of the mitochondrial fractions from
      liver of rats, which were treated with ethanol (1 ml of 32% solution daily for 7
      days, intraperitoneally), liberated into the subfraction of soluble mitochondrial
      proteins significantly less AMP-deaminases, as compared with the control animals.
      The enzyme preparations obtained from intoxicated and intact animals were quite
      similarly inactivated by controlled heating, deaminated at similar rates AMP,
      ADP, FAD and some other nitrogenous compounds (but did not deaminate adenosine
      and some structural analogues of AMP). However, an inhibitory effect of the
      structural analogues of AMP and of nucleosides was significantly higher towards
      the AMP-deaminase from healthy rats as compared with the corresponding enzyme
      preparations obtained from the ethanol-treated animals. The increase in velocity
      of enzymatic AMP deamination in the subfraction of soluble mitochondrial proteins
      apparently does not represent a suitable target for possible therapeutic
      approaches to control the phenomenon, observed in the experimental ethanol
      intoxication, of stimulation of the deaminating activity in total mitochondrial
      fraction of rat liver.

PMID- 1035995
TI  - [Characteristics of RNA isolated from the nuclear RNA-synthesizing complex of
      influenza virus].
AB  - When Ehrlich ascitic carcinoma cells infected with classical fowl plague virus
      and treated with actinomycin D were pulse labeled for 10 min with 3H-uridine, it
      was mainly incorporated into nucleoplasm structures sedimenting in sucrose
      gradients at 120S. At 2-hr exposure of the infected cells to 3H-uridine
      radioactivity was found in nucleoplasm in the area of 65S and in the cytoplasm in
      30-40S zone. The analysis of RNA isolated from these structures gave the
      following results. The RNA isolated from 120S structures sedimented in two zones
      of sucrose gradient: 11S and 16-23S. The 11S RNA was resistant to RNA-ase, while
      16-23S RNA was sensitive to RNA-ase. A similar (16-23S) RNA was isolated from
      virus-specific structures 65S and 30-40S.

PMID- 1035996
TI  - [Comparative antiviral and interferonogenic activity of synthetic
      polyribonucleotide complexes of poly(I).poly(C) and poly(G).poly(C) in different
      cell systems].
AB  - The antiviral and interferon-inducing activity of synthetic polyribonucleotide
      complexes poly(I)-poly(C) and poly(G)-poly(C) was studied in chick embryo, mouse
      embryo and rabbit kidney cell cultures. In chick embryo cell cultures both
      polyribonucleotides had similar antiviral activities. The interferon-inducing
      activity was more marked in poly(G)-poly(C) than in poly(I)-poly(C). In the other
      two cell cultures poly(I)-poly(C) was considerably superior in both activities.
      The revealed differences in the comparative activity of the polyribonucleotides
      in relation to the kind of tissue culture were not associated with differences
      between them in toxicity, sensitivity to pancreatic RN-ase or with possible
      differences in the duration of the contact with cells necessary for the
      achievement of the antiviral effect.

PMID- 1035997
TI  - [Abortive influenza virus infection in Ehrlich ascitic cancer cells. Further
      studies of the properties of ascitic virus].
AB  - Non-infectious virus particles produced by influenza virus (classical fowl
      plague)-infected Ehrlich ascitic carcinoma cells have the same morphology, size
      and sedimentation rate as the standard virions. Their main difference from the
      allantoic virus is their extreme fragility. They remain intact upon a short-term
      centrifugation in sucrose solutions but desintegrate upon prolonged
      centrifugation. In isopicnic fractionation they are detected in two forms, with a
      density of 1.23 g/ml retaining the hemagglutinating but not the neuraminidase
      activity and with a density of 1.27 g/ml deprived of both hemagglutinating and
      neuraminidase activity. In the electron microscopic examination the 1.23 g/ml
      structure appears as virus particles with defective areas in the surface spikes
      layer whereas the 1.27 g/ml structure has no spike layer at all. The protein
      analysis by polyacryl amide gel electrophoresis revealed a sharply reduced amount
      of the membrane protein in the ascitic virus. A hypothesis is suggested according
      to which the reduced amount of the membrane protein is the cause of the unusual
      fragility of ascitic virus particle membranes as a result of which they readily
      lose glycoproteins which, in its turn, leads to their reduced infectious
      activity.

PMID- 1035998
TI  - [Problem of the relationship between social and biological factors in forensic
      psychiatry].

PMID- 1035999
TI  - [Compensation of diabetes mellitus].

PMID- 1036000
TI  - 3H-GABA uptake and acetylcholinesterase activity in dissociated cell cultures of
      the medial hypothalamus.
AB  - Medial hypothalamic tissue of 1 to 4 days old rats was dissociated and cultured
      in vitro for 8--10 days. Neuronal perikarya were demonstrated by supravital
      methylene blue staining and electron microscopy. Synapses with typical vesicles
      and subsynaptic thickening were also observed. 3H-GABA was taken up into a small
      percentage of the cells in the cultures. Neuron-like perikarya and long processes
      accumulated the label while many neurons contained much less activity. Some
      astroglial and oligodendroglial cells and processes also accumulated GABA. A few
      neurons in these cultures contained acetylcholinesterase. It is concluded that
      neurons concentrating GABA and containing acetylcholinesterase are present in the
      hypothalamus of rats of 1 to 4 days of age and can be maintained in dissociated
      cell culture.

PMID- 1036001
TI  - Effect of thyroid hormone on initiation of persistent oestrus in the rat.
AB  - When rats are exposed to continuous illumination persistent oestrus and
      polyfollicular ovaries develop. Thyroidectomy at 24 days of age (juvenile rats)
      prevents the onset of persistent oestrus and polyfollicular ovaries under
      exposure to constant light, and irregular ovulation continues to occur.
      Replacement with 1.75 microng L-thyroxine in these rats produces a prolonged
      oestrus. However, in adult persistent-oestrous rats (90 days after exposure to
      continous illumination) thyroidectomy does not interrupt persistent vaginal
      cornification. In rats receiving 100 microng of testosterone propionate
      subcutaneously at 5 days of age, persistent oestrus and polyfollicular ovaries
      develop. Thyroidectomy at 24 days of age (juvenile) prevents the onset of
      persistent oestrus and the development of polyfollicular ovaries, however,
      ovulation is not observed. Replacement treatment with 1.75 microng L-thyroxine in
      these rats produces a prolonged oestrus and polyfollicular ovaries. However, in
      adult persistent oestrus rats, thyroidectomy at 130 days does not interrup
      persistent vaginal cornification. From these facts, it may be inferred that
      circulation of a physiological level of thyroid hormone in juvenile rats is
      necessary for the development of oestrogen binding receptors in the hypothalamus.
      Therefore, a hypothyroid state during the juvenile stage interferes with the
      development and maturation of hypothalamic controlled pituitary ovarian function.

PMID- 1036002
TI  - Observations on the effects of danazol on the female reproductive tract of mice.
AB  - Antifertility and oestrogenic effects of Danazol have been studied in female
      mice. Danazol brings about suppression of ovarian weight, presumably by
      inhibiting gonadotropin secretion. Enlargement of uterine horns and well defined
      vaginal keratinization was seen in Danazol treated ovariectomized animals. The
      results were similar to that of oestradiol dipropionate confirming the estrogenic
      activity of Danazol.

PMID- 1036003
TI  - Effects of cadmium chloride on the testis and sex accessory glands of the Indian
      palm squirrel, Funambulus pennanti (Wroughthon).
AB  - A single subcutaneous injection of cadmium chloride caused reversible destruction
      in the testis of palm, squirrel, Funambulus pennanti. Marked regression in
      testicular weight and seminiferous tubule diameter associated with complete
      necrosis of germinal epithelium was observed after 1, 2, 3, 5 and 7 days of
      cadmium administration. A significant increase in the concentration of testicular
      cholesterol was observed after 5 days treatment. Decrease in the citric acid
      concentration of prostate gland was associated with the degenerative changes of
      the spermatogenic elements. Reduced fructose concentration in the seminal vesicle
      and prostate of cadmium treated animals indicate an inhibition of androgen
      production. Decreased androgen production was also reflected by the atrophic
      seminal vesicles, prostate and epididymides. These effects were reversible and
      about 70% seminiferous tubules showed normal spermatogenesis. The cholesterol,
      fructose and citric acid concentration of testis and sex accessory glands
      returned to subnormal levels after 45 days of cadmium chloride treatment. It is
      suggested that the degenerative effects of cadmium chloride are dose, time and
      species dependent.

PMID- 1036004
TI  - The poly(A)-containing ribonucleoproteins in the nucleus and the cytoplasm of
      ehrlich ascites carcinoma cells.
AB  - The sedimentation characteristics and protein composition of the polyadenylic
      acid-containing ribonucleoprotein (RNP) particles separated from the polysomes of
      Ehrlich ascites carcinoma cells by means of ribonuclease treatment were studied.
      The results were compared with the corresponding characteristics of the poly(A)
      containing particles of the cell nucleus. The sedimentation coefficient of the
      poly(A)-containing RNP from poly-ribosomes was found to be 11 S, while that of
      the nuclear particles was 14 S. In Cs2SO4 equilibrium density gradient values of
      p=1.25 and 1.34 gcm-3 were obtained for the nuclear particles and the poly(A)-RNP
      separated from polyribosomes, respectively. The molecular weights of the proteins
      making up the polysomal poly(A)-particles were found to be over 40 000 daltons,
      i.e. 54 000, 48 000, 68 000 and 89 000 daltons for the four polypeptides present
      in considerable amounts. As far as electrophoretic mobility is concerned these
      proteins were indistinguishable from the proteins of the nuclear poly(A)
      containing RNP. However, the ratio of the components in the two types of particle
      proved to be quite different.

PMID- 1036005
TI  - [Microbiological study of cervical and pharyngeal secretions in the postpartum
      period].

PMID- 1036006
TI  - [Brenner tumor. Bibliographic review and presentation of a personal case with
      estrogenic activity].

PMID- 1036007
TI  - Effect of aminoglutethimide on corpora lutea of pregnant rats.

PMID- 1036009
TI  - Faculty honoraria for continuing education activities.

PMID- 1036008
TI  - The association of multiple induced abortions with subsequent prematurity and
      spontaneous abortion.

PMID- 1036010
TI  - [Fulminant hepatic failure in neonatal period (author's transl)].
AB  - A newbron baby that following an exchange transfusion due to A incompatibility,
      presented an hepatic and renal failure, is reported. Hepatic necrosis and
      associated renal patholgy suspected ruging evolution treated with exchange
      transfusions and peritoneal dialysis for three days, with improvement but, died
      at eight days of age. Necropsy findings confirm clinical suspect of hepatic
      necrosis. Pathology more frequently associated and management of fulminant
      hepatic failure is commented.

PMID- 1036011
TI  - [Determination of antithyroglobulin antibodies: comparison of three immunologic
      methods (author's transl)].
AB  - Antithyroglobulin antibodies were investigated in various thyroidopathy using 3
      immunological technics. The radio-immunological methods are a little more
      sensitive and more reproducible that passive hemagglutination. In the radio
      immunological methods the polyethylene glycol precipitation is less expensive but
      less sensitive and less reproductible than the double precipitation procedure.
      This one imply to perform a dilution curve of positive serum because of the
      modifications of the slope during the dilution. This technic allows a detection
      with high frequency of antithyroglobulin antibodies particularly in Hashimoto
      thyroiditis and chronic thyroiditis. One can observe the higher incidence in
      primary hypothyroidism and in Graves' disease which seems to imply auto-immun
      factors in these diseases.

PMID- 1036012
TI  - Microinjection of tRNA into amphibian oocytes.
AB  - The microinjection technique affords us the possibility to introduce purified
      components into living cells and to answer the question of what effects the
      change introduced has on cellular metabolism. This technique can therefore be
      used to test the hypothesis that transfer RNA plays a regulatory role in cellular
      protein synthesis. Prior to these experiments it is important, however, to test
      whether transfer RNA microinjected into amphibian oocytes is stable and
      functional inside this cells. These two questions are answered affirmatively in
      this report. The stability of tRNA was tested by following the content of TCA
      precipitable counts inside the oocytes at different times after microinjection of
      radioactive yeast and E. coli tRNA and by polyacrilamide gel electrophoresis of
      the material recovered from the cell. The results clearly indicate that tRNAs are
      resistant to the action of occyte ribonucleases that degrade other RNAs such as
      5S RNA. The functionality of the injected tRNA was tested by assaying the
      intracellular aminoacylation of microinjected yeast tRNA. The aminoacylation of
      bulk yeast (3H) tRNA introduced into Xenopus laevis oocytes was tested by the
      capacity of the material recovered 5 hours after injection into the cell to form
      a ternary complex with wheat protein synthesis elongation factor 1 and GTP. The
      complex only forms with aminoacyl-tRNA and not with unacylated tRNA. This method
      showed that at least 80% of the tRNA introduced into the cell was aminoacylated
      in vivo. A direct assay for internal aminoacylation made use of microinjection of
      pure tRNAPhe and subsequent determination by phenol extraction of (14C)Phe-tRNA
      content of oocytes that had been incubated for 2 hours in a medium containing
      (14C)phenylalanine. The results obtained showed that the oocytes could internally
      aminoacylate 200-500 times more tRNAPhe that the cell normally contains.
      Appropiate controls demonstrated that the aminoacylation was aminoacid and tRNA
      specific and that periodate oxidized tRNAPhe could not be in vivo aminoacylated
      but tRNAPhe deprived of its Y base could accept the aminoacid. A brief study
      demonstrated that bulk yeast tRNA and tRNAPhe without its Y base did not inhibit
      endogenous protein synthesis but a similar amount of tRNAPhe caused 50%
      inhibition and periodate-oxidized tRNAPhe a 95% inhibition.

PMID- 1036013
TI  - [Exceptional variant of the Sturge-Weber disease: intracranial angioblastic
      meningioma and skin hemangioma presenting as a "sneak lesion"].

PMID- 1036014
TI  - [Pathological nontumorous anatomy of the sinus lactiferi on its harmonic
      background and its relationship to latent galactorrhea (apropos an unusual
      squamous metaplasia in ectasic galactocele].

PMID- 1036015
TI  - [Morphofunctional characteristics of the thyroid and parathyroid glands of the
      progeny in the presence of maternal hyperthyroidism].
AB  - The posterity of female albino rats given di-thyroxin (15 mkg/100 g) during
      gestation and lactation differ from off-springs of intact rats by less body
      weight and increased gas-exchange. Their thyroid galnds show evident signs of
      functional suppression, e. g. decreased relative weight, diminished height of
      thyrocytes, cytochemical shifts in the content and topography of RNP and the
      ascorbic acid. During the first 30 days of the postnatal life the parathyroid
      glands have greater weight than controls, are characterized by a number of
      morphological and cytochemical signs suggesting their increased functioning.

PMID- 1036016
TI  - [Senile chorea (author's transl)].

PMID- 1036017
TI  - [Adult type of cerebral lipidosis with multilamellar cytosomes--a case study].

PMID- 1036018
TI  - [Causes for gastro-intestinal symptoms in pellagra].

PMID- 1036019
TI  - [Experimental studies on the etiological mechanism of congenital microcephaly].
AB  - Pregnant mice were injected intraperitoneally on different gestational day with
      either one or three successive doses of 30 mg/kg of cytosine arabinoside (ara-C),
      which has been known to interfere with DNA synthesis. Some of them were injected
      intraperitoneally with tritiated thymidine (3H-TdR) consecutively. The fetuses
      and the youngs were sacrificed at various hours and days after treatment.
      Pyknotic nuclei or nuclear debris were observed at the matrix layer three hours
      after the injection of single dose of ara-C. Nuclear debris were increased as
      time elapse and they were most prominent 12 hours after treatment. However, 24
      hours later, new matrix layer was regenerating. Twenty-four hours after treatment
      with two successive doses of ara-C, labeling index in the matrix layer was about
      one third of that of control. Cerebral hemispheres of the treated youngs were
      reduced in size. The youngs, treated with three successive doses of ara-C on day
      13, 14 and 15 of gestation, showed most severe microcephalus. Cytoarchitecture in
      the cortices of these microcephalic mice was characterized by irregular
      arrangement of the pyramidal neurons and their dendritic branches.
      Autoradiographic study revealed that cortical neurons which were produced at the
      regenerated matrix layer after ara-C treatment migrated to the surface of the
      cortex.

PMID- 1036020
TI  - [Clinical significance of skull scanning in cerebrovascular disorders].

PMID- 1036021
TI  - [Inhibitory effect of a massive dosage of hydrocortisone on the sympathetic
      nervous system].

PMID- 1036022
TI  - [Idiopathic intracranial venous and sinus thrombosis].

PMID- 1036023
TI  - [Subarachnoid hemorrhage].

PMID- 1036024
TI  - [Involuntary movement in Lesch-Nyhan syndrome (author's transl)].

PMID- 1036025
TI  - [3 cases of Moyamoya diseases found in a consanguineous family].

PMID- 1036026
TI  - [Carbon monoxide poisoning].

PMID- 1036027
TI  - [Studies of cerebral circulation in non-infarcted areas in cerebral infarction].

PMID- 1036028
TI  - [Contrast media enhancement in cranial computed tomography --studies of iodinated
      contrast infusion (ICI)].
AB  - The effect of infusion of iodinated contrast material on the enhancement of the
      computed tomography were studied in several kinds of the intracranial lesions.
      Especially, relationship between the degree of the enhancement and the time
      interval after the infusion was examined. It was found that the appearance of the
      enhancement effect were different according to the pathological types of the
      lesions. There were also time differences even in the same lesion before the full
      size of the lesions was demonstrated. The pathological type of the lesions could
      be suggested from the enhanced figures of the lesions, but the diagnosis would be
      more accurate in consideration of the localization of the lesions. It was thus
      concluded that this method was useful for the detection of the precise
      localization and the size of the lesions which were not so clearly demonstrated
      in conventional cranial computed tomography.

PMID- 1036029
TI  - [Wallenberg's syndrome with sleep-induced dyspnea--a case study].
AB  - One case with Wallenberg's syndrome followed by the neck clipping of the
      posterior inferior cerebellar aneurysm was reported. The patient was 49 years old
      female with the subarachnoid hemorrhage, who had previously no history of the
      cardiovascular disease. The vertebral angiogram revealed a saccular aneurysm of
      the left vertebral artery at the origin of the posterior inferior cerebellar
      artery. The preoperative neurological examination were normal, except for the
      slight degree of the meningeal irritation. The surgical intervention was
      successfully performed on 39th day after the subarachnoid hemorrhage.
      Postoperative course was eventful, presenting the typical Wallenberg's syndrome,
      which was complicated the accompanying signs. The troublesome accompanying signs
      were chiefly automatic respiratory dysfunction (sleep-induced dyspnea), autonomic
      dysfunction (Horner's syndrome, perspiration, hypertension), and restless
      confusion. The postoperative vertebral angiogram showed the obliteration of the
      aneurysm and the sufficient circulation of the vertebrobasilar system, especially
      the posterior inferior cerebellar artery. The mechanism of "sleep-induced
      dyspnea" was discussed in detail from the literatures. In addition to the above
      mentioned, it should be stressed that the recognition of "sleep-induced dyspnea"
      and the other accompanying signs are important for the treatment of the patient
      with the brain stem lesion.

PMID- 1036030
TI  - [Myokymia (author's transl)].

PMID- 1036031
TI  - [Olivo-ponto-cerebellar atrophy with personality changes and slight disturbance
      of intelligence].
AB  - H. I., a housewife aged 55 years, began feeling a gait disturbance at 48 years
      old. After this she had incoordination of arms, dysarthria and tremor of hands.
      Aged 54 years, she could not stand up by herself. In addition to these
      neurological signs she had a change of character, such as losing control of
      herself, unreservedness and unceremoniousness, and slight disturbance of
      intelligence. She died at the age of 55 years about seven years after the onset.
      Histopathologically, noticeable changes were observed on the medulla oblongata,
      pons and cerebellum; the severe neuronal loss of the pontine nuclei and the
      olivary nuclei with demyelination and gliosis of the cerebellopetal fibers.
      Especially a great deal of lipofuscin granules in the nerve cells of the frontal
      and temporal lobe were observed. In the substantia nigra some pigmented cells
      were deleted. This case was diagnosed as olivo-ponto-cerebellar atrophy clinico
      histopathologically. We discussed conserning the etiology of the changes of
      personality and slight disturbance of intelligence in relation to
      histopathological changes. It is speculated that the mental disorders are due to
      the degeneration of the nerve cells in the frontal and temporal lobes.

PMID- 1036032
TI  - [Atypical mitochondria and crystallines in chromatolytic neuronal swelling].
AB  - Chromatolytic neuronal swelling was observed in the various brain regions, e. g.
      precentral cortex, pons and anterior horn of the spinal cord etc., of a 50-year
      old woman showing psycho-organic syndrome and various neurological symptoms over
      a period of 14 years. In these inflated, chromatolytic nerve cells, atypical
      mitochondrias and paracrystalline structures were seen. Atypical mitochondrias
      contained membranous trans-somal bridges composed of about 60 A parallel
      filaments with a spacing of about 80 A. Paracystalline structures consisted of 7
      16 hexagonal lattices with electron-light dots 160 A in diameter and with 280 A
      spacing. The goniometer revealed another featue of the paracrystals, i.e.,
      lamellar structures consisting of 4-10 parallel filaments 120 A thick with a
      spacing of 160 A. These paracrystals were compared with similar structures in
      physiological and pathological conditions and the significance of the atypical
      mitochondrias was discussed.

PMID- 1036033
TI  - [Experimental brain neoplasm induced transplacentally by ethylnitrosourea (ENU).
      (1) Sequential, localized observations and pathological studies of microtumors].

PMID- 1036034
TI  - [Effects of administration of a massive dose of hydrocortisone on cerebrovascular
      circulation].

PMID- 1036035
TI  - [Nemaline myopathy a case report].

PMID- 1036036
TI  - [Intracranial hemorrhage in an infant due to vitamin K deficiency --successful
      management of spontaneous intracerebral and subjural hematoma].
AB  - A one-month-old male infant with spontaneous intracerebral and subdural hematomas
      due to vitamin K deficiency was described. He was breastfed. Loose stools
      continued and began to contain blood. He had fever, vomiting and convulsion, and
      became drowsy. The blood studies showed anemia and hypoprothrombinemia. Left
      carotid angiograms revealed intracerebral and subdural hematomas. He was treated
      successfully by immediate operation and administration of vitamin K. 2) Vitamin K
      deficient hemorrhage beyond the immediate newborn period was discussed with
      reference in the literature. Three etiologic factors included, decreased vitamin
      K intake, decreased intestinal absorption of vitamin K and decreased production
      of vitamin K by colon bacteria. The most important factor of the three seemed to
      be low vitamin K intake. Intracranial hemorrhage was recognized in about one
      third of the cases in the literature. It was emphasized that vitamin K deficiency
      occurring beyond the immediate newborn period was very important as a cause of
      intracranial hemorrhage in infancy.

PMID- 1036037
TI  - [Early development of the central nervous system. --II. Stage II of cytogenesis--
      (author's transl)].

PMID- 1036038
TI  - [Effects of norepinephrine and phentolamine on acute intracranial hypertension].
AB  - It is accepted that cerebrovascular dilatation is a constant response during the
      advanced stage of intracranial hypertension. Severe intracranial hypertension
      ultimately associates with profound vasodilatation and reduces cerebral blood
      flow to zero. This irreversible state is called cerebral vasomotor paralysis by
      Langfitt et al (1965). The rich adrenergic nerve supply of the cerebral vessels
      suggests that pressor amines possibly affect the cerebral circulation and the
      cerebral vascular tone. This study is to investigate the reactivity of
      norepinephrine and phentolamine on intracranial pressure (ICP) in patients with
      severe intracranial hypertension. The ICP and systemic blood pressure (SBP)
      monitorings were carried out continuously after the evacuation of intracerebral
      hematomas due to ruptured intracranial aneurysms. Severe intracranial
      hypertension due to brain swelling was observed in these patients. Three stages
      were defined according to the reactivity to norepinephrine and phentolamine on
      the ICP. In Stage I, norepinephrine caused a transient decrease in the ICP and
      phentolamine caused a marked rise in the ICP. Stage II was marked by the absence
      of the ICP response to norepinephrine and phentolamine. During Stage III, the ICP
      changes synchronously with a variation of the SBP after the administration of
      norepinephrine and phentolamine. In Stage I patients, the mean ICP level was
      between 500-1000 mmH2O. Tracing of the ICP in this group showed transient rises
      called pressure waves and the waves were recurring increases in the ICP to value
      of 300-500 mmH2O superimposed on an elevated level of the ICP. On the other hand,
      in Stage II and III patients, the ICP level exceeded 1000 mmH2O. Tracing of the
      ICP in these groups showed only variations by the arterial pulses. The patients
      in Stage I had a well prognosis for life if proper treatments such as continuous
      ventricular drainage were carried out. The patients in Stage II and III had a
      poor prognosis for life inspite of continuous ventricular drainage. There are
      varying stages in cerebrovascular dilatation accompanying intracranial
      hypertension. We have no information on the mechanism of this cerebrovascular
      dilatation at present. However, we speculate that the pressor amines such as
      norepinephrine may partly participate in the mechanism responsible for the
      vasodilation. So, we attempt to grade the degree of this vasodilatation according
      to the reactivity of norepinephrine and phentolamine on the ICP. It is presumed
      that cerebrovascular dilatation is slight and reversible in Stage I patients,
      whereas cerebrovascular dilatation is profund and irreversible in Stage II and
      III patients. Continuous ICP recording and examination of the reactivity to
      norepinephrine and phentolamine on the ICP are valuable when considering the
      prognosis for life in patients with severe intracranial hypertension.

PMID- 1036039
TI  - [Effects of ATP on cerebral circulation--morphological observation of cerebral
      circulation and cerebral vasculature].
AB  - Review was made on the effect of adenosine triphosphate, 1.0-3.0 mg/kg
      intravenously, on the cerebral circulation and the presence of the dilating
      action on the cerebral blood-vessels in cats. 1. The group of the normal intra
      cranial pressure showed, as reported previously, the transient hypotension and
      its complicated decrease of cerebral blood-circulation at the initial period for
      30-100 check, then demonstrating the increase of cerebral blood-flow for 200-1000
      check. Its increased volume and duration were dose-dependent. 2. The group of the
      loaded intracranial pressure of 20-30 mmHg (slightly elevated group) showed the
      increase of cerebral blood-flow, like the group of the normal intracranial
      pressure. However, the effect of ATP showed the decrease or disappearance in
      accordance with the elevation of the loaded pressure. 3. Cerebral vasodilating
      effect of ATP was promptly observed after the administration, and its degree was
      30-50% in photographical observation. 4. Increasing effect on cerebral blood-flow
      and cerebral vasodilating action of ATP were similar in the pattern to that of
      vasodilators such as papaverine hydrochloride.

PMID- 1036040
TI  - [Intracranial pressure--volumetric pressure and driving pressure].
AB  - In order to understand the pathogenesis of increased intracranial pressure, the
      concept of the driving pressure (DP) from the intracranial vascular system was
      proposed. The DP consists of the transmission of atrial pressure (ADP) and venous
      pressure (vp). It is well known that when the animals died, the intracranial
      pressure decreased to the atmospheric pressure. This means that the DP is
      important in maintaining the static pressure of the cerebrospinal fluid. The
      theoretical equation of the intracranial pressure was expressed as
      follows.ICP=ADP+VP (1) ADP is expressed as (2). ADP=eta (BP-VP) (2) The pressure
      transmission rat (eta) was calculated as the ratio of the CSF pressure to the
      systemic arterial blood pressure in the experimental and clinical cases. In the
      normal CSF pressure, eta was very small (2.0 X 10(-2)), while in the severe
      intracranial hypertension, eta approached to 1. The concept of the driving
      pressure was useful to analyze the static intracranial pressure and the pulse
      pressure.

PMID- 1036041
TI  - [Effects of posterior hypothalamus defects on intracranial pressure. (2)
      Comparison between normal group and pressured group].

PMID- 1036042
TI  - [Clinicophysiological studies of orbicularis oculi reflex in brain stem
      diseases].
AB  - Orbicularis oculi reflex is consisted of two components; one is early reflex
      response (R1) which is 14.1 +/- 2.2 msec in latency, and the other is late reflex
      response (R2) that is 35.0 +/- 8.6 msec in latency (mean +/- 2SD). R1 is observed
      on the ipsilateral side of stimulation and R2 is visible bilaterally on ipsiand
      contralateral sides of stimulation. Clinically orbicularis oculi reflex can be
      recorded easily, however, its clinical and physiological significance has not
      been clearly solved. Orbicularis oculi reflex was tested on patients with the
      brain stem lesions of various kinds, and the factors influencing to the reflex
      pathways were examined, such as the site and the type of lesions, sleep, several
      anesthetics and the level of consciousness. Results obtained were as follows; 1)
      both R1 and R2 disappeared or prolonged in latencies by nuclear as well as
      peripheral facial nerve palsy, since the facial nerve was the final common
      pathway. 2) on cases of facial sensory disturbance R1 prolonged in latency with
      concomitant delay of R2 response. 3) both R1 and were attenuated as soon as the
      alpha rhythmicity of the EEG was disappeared. Administration of thiamylal also
      attenuated both the R1 and R2, however, ketamine (a dissociative anesthetic)
      enhanced the R1 in amplitude and suppressed R2. These findings indicated that the
      R1 and R2 were in some extent regulated from brain stem reticular formation and
      the orbicularis oculi reflex should be an useful diagnostic measure to detect
      imparied consciousness. 4) also the reflex should be used to know the extent of
      neoplastic process in the cerebellar hemisphere to the brain stem. 5) recovery
      curve of R1 from double shock stimuli (conditioned and test) indicated that this
      reflex was different from H wave of the spinal cord because of absent refractory
      period and shorter facilitatory period ranging between 40 to 60 msec.

PMID- 1036043
TI  - [Simple method of differential diagnosis of peripheral and central vertigo-
      development of diagnostic method and studies of 178 cases].
AB  - In patients who complain of vertigo or who have equilibrium disorders, it is
      often difficult to determine the etiology of the disorder, that is to determine
      whether it is dependent on a peripheral or central vestibular disorder. To
      attempt to determine the etiology in these cases, we divised a new method, the
      caloric eye tracking pattern test (CETP-Test). Seventeen normal subjects and 161
      patients were tested. The latter group included 33 with peripheral disorders such
      as Meniere's disease, benign paroxysmal positional nystagmus, and others, and 128
      with central disorders such as vertebral basilar artery insufficiency, cervical
      vertigo, and others, were tested. The cases of central disorders were limited to
      those patients whose eye tracking pattern before the caloric stimulation was
      normal. In normal subjects and in patients with peripheral disorders, it is well
      known that caloric nystagmus has little influence on the eye tracking pattern. In
      contrast, in patients with central vestibular disorders, caloric nystagmus evokes
      abnormalities on the eye tracking pattern, either superimposed or saccades,
      despite the fact that the eye tracking pattern before the caloric stimulation is
      normal. First we administer the eye tracking stimulation test using a target
      which moves horizontally at 0.3 cycle per second. Next, we perform the caloric
      test on the right ear, using 20 c.c. of ice water for 10 seconds. During the
      evoked caloric nystagmus we administer the eye tracking test once again. The eye
      tracking pattern is recorded for 20 seconds beginning 50 seconds after the start
      of the ice water injection. The procedure repeated on the left ear. The results
      on each case are presented as three patterns of ENG-recording. We may stat that
      in normal subjects and in patients with peripheral vestibular disorders, visual
      suppression of caloric nystagmus remains functional. Caloric induced nystagmus
      does not affect the CETP. In patients with central vestibular disorders, visual
      suppression of caloric nystagmus does not function properly because of defects in
      the visual suppression mechanism. Therefore, caloric nystagmus greatly influences
      the CETP. Consequently, the CETP may not be smooth when CETP test is administered
      to patients with central vestibular disorders. We may say also that the visual
      suppression to the vestibular nystagmus is evoked more strongly by pursuing a
      moving visual stimulus than by gazing a stational target. These results allow for
      a differential diagnosis between peripheral and central disorders.

PMID- 1036044
TI  - [Congenital anomalies of cerebral artery and intracranial aneurysm].
AB  - It is well known that congenital anomalies such as polycystic kidney, aortic
      coarctation, Marfan syndrome, Ehler-Danlos syndrome are apt to be complicated by
      intracranial aneurysms. In this report we attempt to reveal the relation and
      incidence between cerebrovascular anomalies and intracranial aneurysms. The
      etiology of aneurysms has been discussed, too. 12 cases of persistent trigeminl
      artery, 2 cases of persistent hypoglossal artery and 11 cases of fenestration
      were obtained from 3841 patients who were angiographically examined in our clinic
      for 5 years. The incidence is 0.31%, 0.05% and 0.29%, respectively. Persistent
      trigeminal arteries were complicated by 2 cases of intracranial aneurysms and one
      case of arterivenous malformations (AVM), persistent hypoglossal arteries were
      complicated by one case of aneurysm, and fenestrations were complicated by 2
      cases of aneurysms and one case of AVM. One case of congenital agenesis of right
      internal carotid artery was obtained which was complicated by aneurysm of
      anterior communicating artery. Totally, 8 cases of aneurysms and AVM were
      obtained from 26 cases of cerebrovascular anomalies (incidence 30.8%). On the
      other hand, thalamic or caudate hemorrhage revealed the highest incidence of
      complication of intracranial aneurysms among intracerebral hematomas (10.7%).
      Compared with the incidence of aneurysms between cerebro vascular anomalies
      (30.8%) and thalamic or caudate hemorrhage (10.7%), the difference is
      statistically signigicant (P less than 0.05). The cause of intracranial aneurysm
      has not yet been clarified. But it is well accepted that the defect of tunica
      media vasorum is most responsible factor as to the occurrence of intracranial
      aneurysms. We concluded that the genetic error of cerebral vessels including
      defect of media caused intracranial aneurysms, and this result was supported from
      the evidence that cerebrovascular anomalies showed statistically high incidence
      of complication of intracranial aneurysms.

PMID- 1036045
TI  - [Development of the central nervous system. III. Stage III of cytogenesis: stage
      of neuroglia differentiation (author's transl)].

PMID- 1036046
TI  - [Hypertensive intracerebral hemorrhage its diagnosis and operative indication
      (author's transl)].

PMID- 1036047
TI  - [Comparative neurological observations on the cerebellum].

PMID- 1036048
TI  - [Autopsy case of a family with hereditary ataxia].

PMID- 1036049
TI  - [Hepato-cerebral diseases caused by abnormal amino acid metabolism  ---clinical
      observation in 3 cases of citrullinemia].

PMID- 1036050
TI  - [Analysis of anterior fontanelle pulsation wave. 1. Relationship between the
      pulsation wave and intracranial pressure].

PMID- 1036051
TI  - [Diagnosis and management of transsphenoidal encephalocele --case study and
      review of the literature].

PMID- 1036052
TI  - [Serial cerebral angiography of late onset epilepsy].

PMID- 1036053
TI  - [Oral dyskinesia (author's transl)].

PMID- 1036054
TI  - [Measurement of intracranial pressure: 1. historical review (author's transl)].

PMID- 1036055
TI  - [Analysis of the pulse wave of the anterior fontanelle. (2). Amplitude of the
      pulsating wave, and age of the infant (in months) in relation to the thickness of
      the cerebral parenchyma].

PMID- 1036056
TI  - [Central mechanism of the gastric inhibitory and excitatory reflexes via the
      splanchnic nerve efferent pathway].

PMID- 1036057
TI  - [Abnormal basilar vascular network containing an aneurysm, with special
      referrence to morphological findings with surgical microscopy].

PMID- 1036058
TI  - [Intracranial pressure monitoring apparatus for clinical use balanced pressure
      sensors].
AB  - Three types of pressure sensors, (1) electric pressure switch, (2) fiber optic
      pressure switch and (3) pressure indicating bag for intracranial pressure
      monitoring which were developed by the author are described. Advantages and
      disadvantages between them are also discussed. The electric pressure switch is
      relatively simple in construction but has a possibility of producing micro-shock
      hazard in case of accidental electric leakage. The fiber optic pressure switch is
      the safest for the micro shock but its structure is rather complicated and
      fragile. The pressure indicating bag is simple to make and durable to use.
      However, it has a hydrostatic effect.

PMID- 1036059
TI  - [Atypical Alzheimer's disease--an autopsy case].

PMID- 1036060
TI  - [Left atrial myxoma with repeated multiple cerebral emboli].
AB  - A case of left atrial myxoma with repeated multiple cerebral emboli is reported.
      A-44-year-old man first developed a sudden right hemiparesis in October 1969.
      After intensive physical theraphy, strength improved and he was able to return to
      his work. In March 1970, he suddenly lost consciousness and remained comatose for
      a day. Upon waking, he had a profound right hemiparesis, motor aphasia and
      Gerstmann's syndrome. He was admitted to Hiroshima City Hospital on August 1,
      1970. The cardiac examination, including an electrocardiogram, was entirely
      normal. Laboratory studies revealed a normal blood count and urinalysis;
      erythrocyte sedimentation rate was elevated (32mm/hour). On a left cerebral
      angiographic study, performed on September 6, 1971, multiple aneurysmal
      dilatations of the branches of the left middle cerebral artery were demonstrated.
      No specific diagnosis was made. In January 1973, he developed dysarthria,
      dysphagia and quadriplegia because of the recurrent cerebral attacks. He had a
      high temperature continuously for three days and died on May 30, 1974. At autopsy
      a myxoma with the peduncle was attached to the septal wall of left atrium, and
      there were old infarcts in the brain, the myocardium and the kidneys.

PMID- 1036061
TI  - [Intentional hyperkinesis].

PMID- 1036062
TI  - [On the recently experienced several clinical cases--clinical and pathological
      instructions--(author's transl)].

PMID- 1036063
TI  - [Experimental brain neoplasm induced by ethylnitrosourea. Frequency of incidence
      and neurological manifestation in rats].

PMID- 1036064
TI  - [Congenital muscular dystrophy associated with micropolygyria of the cerebrum and
      cerebellum].
AB  - The characteristic features of micropolygyria were demonstrated in the cerebral
      and cerebellar gray matter of two cases, 5 and 16 years old males, of congenital
      muscular dystrophy. (Fokuyama type). The micropolygyria of the cerebral cortex
      showed an undifferentiated cytoarchitecture, e. g. status verrucosus deformis. On
      the surface of cortical molecular layer, subpial mesenchymal fibres, tangential
      myelin fibres and marginal glial fibres were observed to be still proliferated
      even at the stages examined and all the fibres were caved into the cortical cell
      layer associated with the molecular layer, without secondary sulcus formation. It
      is proposed that micropolygyria without secondary sulcus formation described in
      the present paper is named as "pachygyric micropolygyria", while four-layered
      type of micropolygyria with normal sulcus formation is "eugyric micropolygyria".
      On the other hand, micropolygyria of the cerebellar cortex was found to be
      consisted of various sized fragments in which basic structures of the cerebellum
      were preserved. On a part of surface of the cerebellar cortex the
      cytoarchitecture of cell layers was shown in inverse order. The Purkinje cell
      were irregularly migrated and the external granular layer remained in the
      molecular layer showing ectopic features. Tangential myelin fibres, connecting
      with fibres of the folial white matter, were observed to exist on the surface of
      the internal granular layer.

PMID- 1036065
TI  - [Etiological studies of cerebrovascular Moyamoya disease].

PMID- 1036066
TI  - [2 cases with unusual lid-jaw co-movements].
AB  - General review of the literature makes it apparent that there exist various
      combinations of associated movements between cranial nerves. Most of them involve
      four of nerves, the oculomotor, the abducens, the facial, and the motor potion of
      the trigeminal nerve. We report two patients in whom left upper eyelids produced
      peculior up and down movements in accompany with mastication. The one was a 9
      year-old female who had shown left eye-lid retraction since 3 months; the other,
      a 4-year-old male, had produced the synkinesis one year since. Either children
      showed contraction of left palpebral levators associated with volitional mouth
      opening, deviation of the mandible toward the right, and sucking. Their pupils
      were normal and their upper eye-lids showed no ptosis on the affected side. The
      EEG showed high voltage rhythmic slow waves in parieto-occipital areas
      bilaterally. Head injuries or hereditary defects not being recorded in their
      histories, their synkinesis is assumed to be congenital in orgin. Abnormal neural
      connections have been presumed to be affected in the course of the development
      between the trigeminal and the oculomotor nuclei within the midbrain. In
      triggering the synkinesis, however, stretched muscle-spindles of the masseter
      muscle most play an important role. After all, synchronizing lid-jaw co-movements
      as observed in our two children represent an unusual pattern of the Marcus Gunn
      phenomenon.

PMID- 1036067
TI  - [Kinetics of extracellular potassium at the epileptogenic focus].

PMID- 1036068
TI  - [Epidemiological studies of brain dysfunction in the schistosomiasis-endemic
      area, with special reference to EEG findings].

PMID- 1036069
TI  - [Myoclonus in subacute sclerosing panencephalitis].

PMID- 1036070
TI  - [Measurement of intracranial pressure 3: significances of the open manometer and
      the pressure transducer (author's transl)].

PMID- 1036071
TI  - [Autopsy case of progressive subcortical gliosis].
AB  - A case of a 44-year-old male with progressive subcortical gliosis was presented.
      The clinical manifestations included mental activity, difficulty in attention,
      euphoria and inability to work. The impairement of memory was not evident and his
      personality was fairly well preserved. Neurological examination showed no
      abnormality. The course was progressive without remission and the patient died
      with pneumonia approximately fifteen months after the onset of the disease.
      Laboratory tests revealed unremarkable except for slight degree of glucosuria and
      elevated F.B.S. Electroencephalography and carotid angiography were within
      normal. Neuropathological finding revealed that brain weighed 1200 g. and
      moderate degree of atrophy on frontal to parietotemporal lobes was evident.
      Occipital lobe was not involved. Microscopic examination revealed such changes as
      fibrillary gliosis in the cerebral white matter and grey matter in the spinal
      cord. The lesion in the cerebral white matter was predominent in the frontal
      lobe. Striatum and brain stem also showed mild degree of fibrillary gliosis. No
      senility related change such as senile plaque, granulovacuolar degeneration and
      Alzheimer's neurofibrillary tangle was found. The clinicopathologic findings in
      this case supported a diagnosis of progressive subcortical gliosis which was
      first described by Neumann in 1949.

PMID- 1036072
TI  - [Cerabral angiography of acute brain infarct. Follow-up studies of middle
      cerebral artery occlusion].

PMID- 1036073
TI  - [Traumatic aneurysm of the peripheral cerebral artery].
AB  - Two cases of traumatic aneurysm of peripheral cerebral artery were reported. Case
      1. A 6-year-old girl was severely injured on her head by automobile accident.
      Plain skull films showed depressed fracture in the left frontal region. Left
      common carotid angiogram 25 days after the injury revealed small aneurysm of a
      cortical branch of the anterior cerebral artery. Cranioplasty and removal of the
      aneurysm was performed. Postoperative course of this patient was uneventful. Case
      2. A 4-year-old girl fell downstaris and struck her left temporal region. On
      admission, she was unconscious and plain skull films showed multiple linear
      fractures. No aneurysm was demonstrated in the right common carotid angiogram
      immediately after the head trauma. Since her general condition gradually
      improved, she discharged 23 days after the head trauma. 63 days after the injury,
      she developed sudden onset of severe headache, vomiting, and status epilepticus.
      Right common carotid angiogram showed a large aneurysm arising from a branch of
      right pericallosal artery at the free edge of the falx. Parent artery of the
      aneurysm was clipped. Postoperatively, the patient made uneventful recovery. 60
      reported cases of traumatic aneurysm of peripheral cerebral artery were reviewed
      and analyzed in etiology, diagnosis, clinical course, treatment and pathogenesis.

PMID- 1036075
TI  - [Imitative synkinesis].

PMID- 1036074
TI  - [Chronic cerebral ischemia and cerebral ventricular hemorrhage].

PMID- 1036076
TI  - Measurement of intracranial pressure (4): The pressure manometer using balloon
      and its reliability (author's transl).

PMID- 1036077
TI  - [Development of 2 cell pattern pinealoma 15 years after total removal of pineal
      teratoma].

PMID- 1036078
TI  - [Clinicopathological studies of the vegetative state--distinction between the
      vegetative state and brain death].
AB  - 10 cases showing vegetative state and 2 cases of brain death due to severe brain
      damage were observed and the differences of clinicopathological findings between
      both states were discussed. The cases of vegetative state can be divided into
      three groups, first is widespread lesion in the cerebral cortex, second is in the
      cerebral white matter and third is in the brain stem. While, the diffuse whole
      brain damage including the vegetative center of the central nervous system causes
      brain death. We should like to emphasize that the most important structure to
      maintain the human life is the vital center in the brain stem, and that a human
      being, in whom only those function can be preserved, is possible to be alive as
      vegetative state. Prognostic value of the EEG indicating quality of survival
      noted in early stage after severe brain damage has not so important as the flat
      EEG revealed in brain death.

PMID- 1036079
TI  - [Autopsy case of hypertensive pontine hemorrhage with unusual neurological
      manifestations].

PMID- 1036080
TI  - [Temporal arachnoid cysts in children--neuroradiological and etiological
      considerations].

PMID- 1036081
TI  - [Continuous monitoring of internal jugular oxygen saturation--clinical
      application of fiberoptic oximeter].

PMID- 1036082
TI  - [Radiography of the soft tissue of extremities in neuromuscular diseases, with
      special reference to its diagnostic value].

PMID- 1036083
TI  - [Ecological sterotypes of defensive behavior in fish under the action of chemical
      danger signals].

PMID- 1036084
TI  - Students in a class by themselves. Pharmacy faculty and students experiment with
      a modular curriculum.

PMID- 1036085
TI  - [Morphohistochemical study of the rat placenta administered a hepatotropic poison
      at different periods of pregnancy].
AB  - Intragastric administration of CCl4 (0.3 ml per 100 g of body weight) to female
      rats caused a marked injury of the placental tissue and particularly of the
      chorionic epithelium of the labyrinthine portion with the maximal development of
      dystrophic necrobiotic processes on the 14th-16th day of pregnancy (when the
      poison was administered 48 hours before the animal was sacrificed). There was
      noted an increase in the number of mitoses in the epithelial cells at all the
      periods, and a statistically significant enlargement of the nuclei and the
      nucleoli of the cytotrophoblastic cells on the 17th--18th day of the intrauterine
      fetal development. CCl4 administration led to the reduction in the content of
      histochemically detectable glycogen in the cytoplasm of the chorionic epithelium
      and to the fall in the amount of amylase-resistant glycoproteins, protein and RNA
      in dystrophically altered cells.

PMID- 1036086
TI  - [Effect of polychlorocamphene on the organs and their neural apparatus in
      pregnant animals].
AB  - Experiments conducted on pregnant albino rats showed that in daily oral
      administration of polychlorokamphene--a chlorine organic compound widely used in
      agriculature--in a dose of 12 mg/kg (1/20 LD50) there was interrelation between
      the structural and the enzymatic changes in the nerve elements of the organs
      under study. They consisted in the focality of the affection of the nervous
      structures of the brain cortex,  and in increase in the destructive processes
      involving the nervous structures of the heart, uterus, spinal cord at the end of 
      pregnancy. A peculiar enzymatic reconstruction with the preservation of the
      activity of the cholinesterase (CE)-positive pericellular structures (whose
      number was markedly decreased in comparison with control) was noted against the
      background of reduction of the CE activity. The prevalence of destructive
      processes by the end of pregnancy was conditioned by a considerable accumulation
      of the preparation in the heart, uterus, and the brain (as shown by thin-layer
      chromatography). The presence of polychlorkamphene in the organs of fetuses
      pointed to disturbances in the permeability of the transplacental barrier and to
      a possible influence of the preparation on the development of the fetal nervous
      system.

PMID- 1036087
TI  - World Medical Association: Declaration of Tokyo.

PMID- 1036088
TI  - [Prostaglandins and the sexual cycle in domestic animals].

PMID- 1036089
TI  - The role of small animal species in nutrition and food production.

PMID- 1036090
TI  - Use of cell-cycle information in the preparation of drug combinations: results
      with cytosine arabinoside plus actinomycin D1,2.
AB  - Cytosine arabinoside (ara-C) plus actinomycin D acted synergistically in killing
      L1210 and DON cells. The time course of cell-kill by the combination was
      different from that seen for either drug alone. The results obtained (both with
      L1210 and synchronous DON cells) suggest that cells blocked in G1/S with
      continuing unbalanced growth are particularly sensitive to the combined action of
      ara-C and actinomycin D.

PMID- 1036091
TI  - Arrested and cycling CHO cells as a kinetic model: studies with adriamycin.

PMID- 1036092
TI  - Histochemical demonstration of an increase in acetylcholinesterase in established
      lines of human and mouse neuroblastomas by nerve growth factor.
AB  - Cells of three established lines of human neuroblastoma and an established line
      of C1300 mouse neuroblastoma were grown in control medium or in experimental
      medium containing mouse nerve growth factor (NGF). Cultures were stained
      histochemically for acetylcholinesterase (AChE) during log growth and at
      confluency. Human neuroblastoma cells grown in medium containing NGF were
      morphologically more differentiated and they were stained much more intensely for
      AChE during both phases of growth than were cells in control cultures. The enzyme
      was distributed over cell bodies and neurites. Neuroblastoma cells of the mouse
      line were not stimulated to form neurites by NGF, but they were more intensely
      stained for acetylcholinesterase than cells grown in control medium. These
      observations support earlier findings that NGF stimulates differentiation of
      human and mouse neuroblastoma cells in vitro.

PMID- 1036093
TI  - Biological effects of vinyl chloride: an experimental study.
AB  - Plasma activities of alkaline phosphatase, (AP), transaminases and total lactate
      dehydrogenase (LDH) with isoenzymes were determined in mice inhaling 50 and 550
      ppm vinyl chloride (VC). The animals were also autopsied and the tissue pathology
      was studies. The total LDH activity was elevanted in both dose groups along with
      a shift to cathodic enzymes. AP was increased in animals exposed to 500 ppm and
      transaminases were not at all changed. Enzyme changes occurred after the
      appearance of tumors. Alveologenic adenomas occurred in all animals at the higher
      dosage and in about half of the animals inhaling the lower dose. Subperitoneal
      and subcutaneous hemangiosarcomas were frequent in both dose groups; but
      especially among 50 ppm animals. Only one animal had a hemangiosarcoma of the
      liver. No liver fibrosis was seen. All primary subperitoneal and subcutaneous
      tumors were located in fat tissue. Telangiectasis was observed in two animals in
      the 500 ppm series. The importance of blood vessel changes in the toxicology of
      vinyl chloride is discussed.

PMID- 1036094
TI  - [Effect of cholinergic drugs on serotonin metabolism and emotional reactions in
      rats].
AB  - The effects of physostigmine and m-cholinolytics on emotional reactivity,
      aggressiveness, exploratory behavior, along with simultaneous influence on the
      endogenous serotonin metabolism, enhanced by 1-tryptophan serotonin metabolism in
      the brain, were studied. Upon blocking the peripheral effects with methylatropine
      physostigmine exerted a tranquillizing action on emotional reactions without
      producing any significant changes in the serotonin metabolism. Physostigmine
      acted as an antagonist to the traquillizing effect of 1-tryptophan, facilitating
      the catabolism of serotonin. M-cholinolytics--atropine and benactyzine exercised
      a tranquillizing action on emotional reactions, increasing the serotonin level in
      the forebrain and diencephalon.

PMID- 1036095
TI  - [Effect of chronic alcoholic intoxication on the body of rats].
AB  - Experiments involving chronic introduction of ethanol (36 per cent of caloric
      value) as a part of a specially devised liquid ration demonstrated the
      trainability of rats to sharply decrease, their antistress resistance to
      significantly decline, especially in rats kept on a low-protein diet. A general
      tendency toward a reduced activity of acetylcholinesterase in different sectors
      of the brain was revealed both in animals receiving alcohol against the
      background of a normal protein allowance and in those kept on a low-protein diet
      (when compared with the enzyme activity in animals maintained on a ration with a
      normal of protein).

PMID- 1036096
TI  - Dietary factors in renal and hepatic toxicity of paracetamol.

PMID- 1036097
TI  - Parental age and recombination frequency in the house mouse.

PMID- 1036098
TI  - The combinations of the sexes in twin lambings.

PMID- 1036099
TI  - Seasonal variation in oestrus activity and body weight changes in native sheep
      (Jaiselmeri) under semi-arid conditions.

PMID- 1036101
TI  - A note on the oestrus cycle in Bannur sheep.

PMID- 1036100
TI  - Uterine endometrial gland characteristics during estrous cycle in the water
      buffalo.

PMID- 1036102
TI  - Study of seminal attributes in a Holstein Friesian bull associated with partial
      testicular hypoplasia.

PMID- 1036103
TI  - Preliminary observations of 'fertivet' in induction of heat in anoestrous cows
      and buffaloes.

PMID- 1036104
TI  - The malpractice crisis today: I. The year of revolt and political action.

PMID- 1036105
TI  - [Pregnancy type nephropathies experimentally induced in rats].
AB  - The theory behind our work is the following: toxaemia may be due to the
      accidental passage of fetal proteins into the maternal organism. Particularly
      suspect are alpha-fetoproteins from the fetal blood or the amniotic fluid. The
      experiments were carried out on rats by injecting amniotic fluid or fetal serum
      into the rats by different routes and rhythms and in different doses. Arterial
      blood pressure readings showed that the levels were consistently higher than
      those of controls. The study of the kidneys anatomo-pathologically shows the
      following triad: intense congestion, tubular lesions, connective tissues
      affected. These lesions are reversible. The discussion concentrates on the
      similarities and differences between these findings and pathological changes
      found in kidneys in pregnancy.

PMID- 1036106
TI  - [Pregnancy in a rudimentary uterine horn].

PMID- 1036107
TI  - [Choriocarcinoma developing for 9 months under the deceptive mask of
      salpingitis].

PMID- 1036108
TI  - Recent advances in the genetics of diabetes.

PMID- 1036109
TI  - Legal rights of the voluntary patient.

PMID- 1036110
TI  - Prevention and treatment of eye complications in leprosy.

PMID- 1036111
TI  - [Interaction of allogeneic lymphocytes and precursor cells during the primary and
      secondary immune response].
AB  - A mixture of lymph node cells from CBA mice and spleen cells from C57Bl/6J mice
      stimulated by the cheep erythrocytes fro the first or second time was
      transplanted in the lethally irradiated mice (CBA X C57Bl/6j)Fl. The interaction
      of allogenic cells during the secondary immune response was accompanied by the
      complete inactivation of antibody producents. Under the ratio of interacting cell
      elements 1 : 1-1 : 2, 93-96% of precursor cells and 98% of antibody forming cells
      were inactivated. Under the ratio 1 : 5, the index of inactivation of precursor
      cells fell down to 35%. During the primary response, under the ratio 1 : 1, only
      20-48% of precursor cells and 68% of antibody forming cells were inactivated.
      Under the ratio 1 : 2, no inactivation of precursor cells was observed and, under
      the ratio 1 : 10, the antibody formation was stimulated. Following the delayed by
      1-3 days transplantation of CBA lymphocytes, the cooperative effect was
      registered with respect to the spleen cells from C57Bl/6J mice stimulated by the
      erythrocytes for the first time. The interaction of allogenic cells resulted in
      the 3-4-fold increase in the number of antibody forming cells.

PMID- 1036112
TI  - [Obtaining chimeric embryos of groundling for study of the role of cellular
      interactions in early development].
AB  - A methos of production of chimaeric embryos of the loach by parabiosis of whole
      embryos and a whole embryo and an isolated blastodisc is proposed. The parabiosis
      was shown to be possible between the embryos of both the same and different ages
      during cleavage and blastulation. The relation between the frequency of
      parabiosis and the age of embryos and temperature was studied. An electric
      coupling is established between the cells of parabionts, similar by its value to
      that between the cells of each parabiont. The interrelations of cells of
      chimaeric embryos are considered as a model for studying the role of cell
      interactions during embryogenesis.

PMID- 1036113
TI  - [Duration of meiotic prophase stages during oogenesis in the newt Triturus
      cristatus cristatus].
AB  - The duration of the early stages of meiotic prophase was determined in the
      oogenesis of T. cristatus cristatus by means of autoradiography. The oocytes were
      being investigated during 39 days from the moment of 3H-thymidine injection. It
      was shown that preleptotene lasts 1--2, leptotene ca. 4, zygotene 5 and pachytene
      26 days. When studying the preparations obtained 1 day after the injection of 3H
      thymidine, the silver grains were found to be localized over the nuclei at all
      stages of meiotic prophase; this suggests the amplification of rDNA which begins
      in leptotene-zygotene and ends in early diplotene.

PMID- 1036114
TI  - [Damaging effect of 3H-uridine on tissue culture cells during the logarithmic and
      stationary phases of growth].
AB  - The Chinese hamster fibroblasts entered the stationary phase of growth after 5.5
      days of cultivation. The induction of the culture proliferation occurred within
      the first 4 hrs of cultivation in the fresh nutrient medium. After addition of 3H
      uridine in high concentration and with high specific activity (75 micron Cu/M and
      23 Cu/mM), in the stationary phase a lesser number of cells with aberrations and
      a higher mitotic index were noted than in the logarithmic phase. 3H-uridine
      injured the cells in the stationary phase of growth but  to a lesser extent than
      those in the logarithmic phase, i. e. during the intensive RNA synthesis in
      cells.

PMID- 1036115
TI  - [Method of obtaining enzymatic preparations of lipase from the fungi of the genus
      Geotrichum under semi-industrial conditions].
AB  - A method of manufacturing stable enzymic preparations of lipase from fungi
      Geotrichum candidum and G. asteroides under semi-industrial conditions has been
      developed. The paper describes the preparation of the inoculate, fermentation
      nutrient medium, scheme of cultivation and isolation of the raw enzyme with a
      yield of 31.2%.

PMID- 1036116
TI  - [Elimination of phenylalanine from amino acid mixtures obtained from yeast
      hydrolysates and autolyzates].
AB  - In order to obtain amino acid mixtures devoid of phenylalanine, adsorption of
      aromatic amino acids was studied during their chromatography on ion-exchange
      resin IA-Ip. When 40 g of the amino acid mixture were passed through 400 ml of
      the swollen ion-exchange resin, phenylalanine and tyrosine were eliminated and
      67% of dry substance were yielded. Ion-exchange resin adsorbed phenylalanine and
      tyrosine could be regenerated. The use IA-Ip is advantageous as compared with
      that of ion-exchange resin Amberlite IR-45 and activated charcoal.

PMID- 1036117
TI  - Environmental enrichment and crowding: behavioral and hormonal effects.

PMID- 1036118
TI  - Adrenalectomy: protection from kindled convulsion induced amnesia in rats.

PMID- 1036119
TI  - Feeding patterns of theophyllinized rats and effects of dextrose on their food
      intake.

PMID- 1036120
TI  - [Reflexions on life in centers of semi-liberty and on the place of adolescents in
      society].

PMID- 1036121
TI  - [State of the adrenal cortex in the progeny of irradiated female rabbits].

PMID- 1036122
TI  - [Introduction to toxic proteins (author's transl)].

PMID- 1036123
TI  - [Flight errors in relation to predisposing or determining human factors in the
      psychological field. Relations between productive-rational thought and pre
      logical or primitive thought regarding flight activity].

PMID- 1036124
TI  - [Ichthyosarcotoxism. IV. Ciguatera].

PMID- 1036125
TI  - Hypodontus macropi, Monnig, 1929 from a Bennetts' wallaby Macropus rufogrisea.
AB  - Hypodontus macropi was found in Macropus rufogrisea. Males measured 12.73--13.93
      mm in length; one female was 19.07 mm in length. The buccal capsule was funnel
      shaped. The mouth opening was directed antero-ventrally. There was a pair of
      large cutting plates on the dorsal margin of the buccal capsule. The brusal rays
      were well-developed. Spicules were equal and each bore a cuticular wing. A
      gubernaculum and a telamon were present. The vulva was situated near the anus.
      The female tail, 0.163 mm in length, was suddenly tapering.

PMID- 1036126
TI  - [Standardization of sera against viral enteritis of geese].

PMID- 1036127
TI  - [Effect of interferon on experimental herpes simplex virus infections (author's
      transl)].

PMID- 1036128
TI  - [Properties of the virus isolated from hand-foot and mouth disease patients in
      1969-1970 (author's transl)].

PMID- 1036129
TI  - [Clinical genetics of diseases with hereditary predisposition].

PMID- 1036130
TI  - [Ultrastructure of the spermatozoid of a cestode Tetraphyllidea phyllobothriidae
      : Echeneibothrium beauchampi, Euzet 1959].

PMID- 1036131
TI  - Bovine ostertagiosis, a review. Analysis of types and syndromes found in France
      by post mortem examinations and total worm counts.
AB  - We have completed an analysis of the total worm counts (including digests)
      performed on 74 weaned cattle of various ages and sacrified in our laboratory. We
      identified 21 cases of animals suffering from Ostertagiosis (harbouring over
      40,000 adults + immatures in the lumen and the mucosa) or moribund animals
      showing symptoms and lesions of Ostertagiosis. The results are presented with the
      Parasite profiles (percentage of G.I. genera) and Parasite levels ("Very low, Low
      and Average" for carrier animals and "High" and "Very High" for animals suffering
      from parasitism). We have observed typical cases of Type I on weaned calves but
      not on calves grazing when suckling their own dams (Charollais, Limousin type),
      Pretype II and typical Type II on 2 year old or older animals. Variants of Type
      II were found : Fasciologis/Ostertagiosis complex and Parturient Ostertagiosis
      which seems to be well-known by practitioners. Complexes of a clinical Type II +
      stage of Pretype II with 1 to 2 million hypobiotic L4 larvae could explain the
      difficulty to control very severe diseases. Oedematous ostertagiosis is also
      described as an original type or syndrome in 2 to 3 year old cattle : the typical
      lesion is a dramatic oedema of the abomasum which is found enlarged up to X 2 or
      X 3 times its normal size/weight. The abomasal folds and the edges are filled
      with a watery oedema and have an appearance of "foetal membranes". As only few
      parasites are present the disease is considered to be an allergic over reaction
      in adult animals. It is recommended that the peptic digestion of the abomasal
      mucosa and differential counts of the various developmental stages of the
      parasites be added to the routine technique used in diagnosis laboratories.

PMID- 1036132
TI  - [Effect of thyroxine on the diurnal rhythm of the mitotic activity and parameters
      of the life cycle of cells of the liver and esophagus].
AB  - The duration of the cellular cycle and the diurnal rhythm of the amount of
      mitosis were studied in young rats in normality and under the influence of
      thyroxin. The parenchymal and connective-tissue cells of the liver and cells of
      the liver and the cells of the oesophagus epithelium basal layer were studied. It
      was found that under the influence of thyroxin there occured a shortening of the
      periods of the cellular cycle and a 3--6 h shift to the left of the diurnal
      rhythm curve of the amount of mitoses. In thyroxinized animals the 21--95%
      increase of the amount of mitoses in the period of maximum values of the mitotic
      index during a day was observed as compared with control animals. A conclusion is
      made about the diurnal rhythm of sensitivity of G0-phase cells to the
      synchronizing factor, suggesting the decisive significance of the state of the
      cell population in the interaction of the tissue and hormone cells. The data
      obatained in the work show that the thyroid hormones regulate the cellular
      reproduction in the organism by stimulating the cells in the division cycle,
      synchronization of greater amount of cells by the moment of beginning of the
      mitotic cycle at a definite time of day and by shortening the period of the cell
      mitotic cycle.

PMID- 1036133
TI  - Subcellular distribution of a rat hepatic binding protein specific for uridine
      diphosphoglucose.

PMID- 1036134
TI  - Protection of chlorophyll by phospholipids from photooxidation.

PMID- 1036135
TI  - Transition metal ions induce cell growth in NRK cells synchronized in G1 by
      picolinic acid.

PMID- 1036136
TI  - Purification of the sperm-binding factor from the egg of the sea urchin,
      Hemicentrotus pulcherrimus.

PMID- 1036137
TI  - Association of a GDP binding activity with initiation factor eIF-2 from calf
      liver.

PMID- 1036138
TI  - The relationship between surface protease activity and the rate of cell
      proliferation in normal and transformed cells.

PMID- 1036139
TI  - [Effect of destruction of the posterior hypothalamus on intracranial pressure
      (1). Study on the development of vasomotor paralysis].

PMID- 1036140
TI  - [Posttraumatic chronic encephalopathies ; Neuropathological review and
      investigation (Part I) (author's transl)].

PMID- 1036141
TI  - [Determination of cerebral blood flow in the rat].

PMID- 1036142
TI  - [Ultrastructural study of histogenesis of pinealoma].

PMID- 1036143
TI  - [Electroencephalograph and acute consciousness disturbance due to subarachnoid
      hemorrhage following rupture of intracranial aneurysms].

PMID- 1036144
TI  - [The primitive genesis of the central nervous system (Part 1) (author's transl)].

PMID- 1036145
TI  - [Recovery processes in 2 cases of bilingual aphasia].
AB  - Recovery processes of two English-Japanese bilingual aphasics were investigated
      with special emphasia on the effect of language therapy. Although the two
      patients had different types of aphasia (one Broca's aphasia and the other
      Wernicke's aphasia), the degree of the language impairment initially manifested
      in English and Japanese was almost equivalent in each case with the pattern of
      impairment corresponding to the respective types of aphasia. In either case,
      language therapy was conducted in English, and the course of recovery during the
      first six months was analyzed. The results indicated that auditory comprehension
      improved almost simultaneously in both treated (English) and untreated (Japanese)
      languages regardless of the type of the patients' aphasia. In contrast, oral
      language production in Broca's aphasia improved only for the treated language
      while that in Wernicke's aphasia improved simultaneously for both languages.
      Writing ability seemed to improve as a function of language therapy in both
      cases. The implications for the relationship between spontaneous recovery and the
      effects of treatment were discussed.

PMID- 1036147
TI  - [Palatal myoclonus (author's transl)].

PMID- 1036146
TI  - [Influence of gazing at a fixation point and total visual field on
      electroencephalograms].

PMID- 1036148
TI  - [Normal intracranial pressure. The theory of open and closed cavities].

PMID- 1036149
TI  - [Vascular factors in adhesive arachnoiditis of the opto-chiasmatic region].

PMID- 1036150
TI  - [Successful surgical management with anastomosis of the superficial temporal
      artery and the cortical branch of the middle cerebral artery in 2 cases of
      transient cerebral ischemic attacks].

PMID- 1036151
TI  - [Antiepileptic activity of clonazepam--an antiepileptic benzodiazepine
      derivative].
AB  - Clonazepam, an antiepileptic benzodiazepine derivative was administered into 30
      patients mainly with incurable type epilepsy. Results were as summarized below:
      (1) Clonazepam was effective in 44.4% of 36 cases of seizures. The initial effect
      was noticed in 55.6%. (2) Clonazepam was proved to have a broad spectrum in its
      efficacy. It showed the highest rate of effectiveness, 71.4%, on psychomotor
      seizures. (3) Clonazepam was effective in all 4 cases of the photogenic epilepsy
      which shows the photosensitivity in the EEG. With the exception of 1 case, the
      sensitivity in the EEG also disappeared responding to clonazepam. (4) The
      Jacksonian type of the partial motor seizure disappeared in 2 cases after the
      administration with clonazepam. (5) The effects of clonazepam of EEG were
      examined in 24 patients. The abnormality of the basic activity, the diffuse
      epileptic discharge and the focal epileptic discharge were improved in 29.2%,
      61.5% and 66.7%, respectively. In addition, the rate of the clinical
      effectiveness was high in the cases with the centrencephalic discharge. (6) Side
      effects were observed to have appeared in 38.9% of the patients. They were mostly
      drowsiness and ataxia. (7) Based on the above-mentioned results, it can be
      claimed that clonazepam is effective on psychomotor seizures, photogenic epilepsy
      and the secondary type of generalized convulsion (Jacksonian).

PMID- 1036152
TI  - [RI cisternography with 111-In-DTPA].
AB  - In contrast to 169Yb-DTPA the usage of 111In-DTPA, a new radiopharmaceutical, is
      not as yet popular for RI cisternography. This report deals with a comparative
      study of these two radiopharmaceuticals for RI cisternography. For the past one
      year 301 RI cisternography. For the past one year 301 RI cisternographies were
      performed in 160 cases at the Neurosurgical Survice of Shizuoka Rosai Hospital.
      Among those 169Yb-DTPA was used in 137 occasions, 111In-DTPA in 53, and both
      169Yb-DTPA and 111In-DTPA in 30. The results of this study were as follow. 1.
      111In-DTPA was chemically stable in intrathecal administration. 2. A reactive
      fever was minimal with 111In-DTPA if any. 3. There was no adverse reaction, such
      as aseptic meningitis, following 111In-DTPA cisternographies. 4. The effective
      half-life of 111In-DTPA was 16 hours, and that of 169Yb-DTPA 22 hours in this
      series. This means the men were exposed to radioactivity less with 111In-DTPA
      than with 169Yb-DTPA. 5. However, there was no difference in diagnostic value
      between these two radiopharmaceuticals, even 48 hours after intrathecal
      administration. From this study 111In-DTPA appears to be more suitable for RI
      cisternography than 169Yb-DTPA.

PMID- 1036153
TI  - [2 cases of unilateral hydrocephalus developing in the fetal period].
AB  - Dilatation of the lateral ventricle may occur as a result of unilateral
      hydrocephalus with obstruction of the foramen of Monro. Two cases with congenital
      dilatation of unilateral ventricle are presented, in which no obstruction of the
      foramen of Monro was demonstrated. The patients had infantile spasm, asymmetry of
      the skull and face, and contralateral hemiparesis. Angiography showed embryonal
      type of the middle cerebral artery. These findings suggest probable presence of
      active unilateral hydrocephalus in the fetal period.

PMID- 1036154
TI  - [Dystonia (author's transl)].

PMID- 1036155
TI  - [Measurement of intracranial pressure: 2. Classification of methods (author's
      transl)].

PMID- 1036156
TI  - [Hemispheric asymmetry in living man, with special reference to the planum
      temporale].

PMID- 1036157
TI  - [Movement disorders of Sydenham's chorea - electomyographic evaluation].

PMID- 1036158
TI  - [Histopathological findings of the nerve and muscles in familial primary
      amyloidosis, with special reference to the mechanism of amyloid fibril
      production].
AB  - T. I., a male aged 38, had a hereditary primary amyloidosis over four generation
      in his family history. He had peripheral neuropathy with dissociated sensory
      disturbances in the lower limbs, impotence, gastrointerstial dysfunction and
      orthostatic hypotention. N. suralis and M. quadriceps femoralis taken from him
      were examined by light and electron microscopy. N. suralis contained a lot of
      amyloids reacting with congo-red in the nerve fibres. Amyloid fibrils were
      remarkably observed around the blood vessels. They were continuous with the
      basement membrane of the endotherial cells. A few deposites were observed around
      the Schwann cell and fibroblasts. In M. quadriceps femoralis, amyloid like
      fibrils were noted in the perivascular spaces. Especially, a great deal of
      amyloid fibrils were continuous with the basement membranes. From this finding,
      it might be speculated that the basement membrane may play an important role in
      the production of amyloid fibrils.

PMID- 1036159
TI  - [Experimental study on epilepsy using a "kindling preparation". Correlation
      between septal seizure development and psychomotor seizure].
AB  - The seizure development was investigated in seven septal kindled cats for
      examining a participation of septal area in psychomotor epilepsy. Daily
      electrical stimulation (mean: 33.5 days) of septal area could lead to the
      "kindled" generalized convulsion. Six stages of behavioral seizure development
      were distinguished: 1) attention reaction, 2) the above and immobility, 3) the
      above and autonomic manifestation, 4) the above and facial twitching, head
      nodding, 5) the above and tonic extension of contralateral forepaw, 6) the above
      and generalized clonic convulsions. Self-sustained after-discharge and
      independent interictal spike discharge appeared in the hippocampus in stage 2 or
      3, in the amygdala and the globus pallidus in stage 3 or 4, and also in the
      ventromedial hypothalamic nucleus in stage 5. Positive transference phenomenon
      was confirmed in bilateral hippocampus, amygdala and globus pallidus. These
      findings show the progressive dissemination of secondary epileptogeneses in these
      secondary brain structures during the septal seizure development. Electrographic
      and behavioral seizure development mentioned above were completely identical to
      those in the hippocampal seizure that we have reported previously. It is
      concluded that psychomotor epilepsies may not only be triggered by the
      hippocampal and amygdaloid foci but by the septum and its related structuresfoei.

PMID- 1036160
TI  - [Wallenberg's syndrome, with special reference to vestibular nuclei lesion].

PMID- 1036161
TI  - [Neuropathology and neurophysiology of cystic encephalopathy with probable
      congenital toxoplasmic encephalitis: an autopsy study].

PMID- 1036162
TI  - [Electroencephalography of head injuries in children].

PMID- 1036163
TI  - [Cerebellar hemangioblastoma with multiple aneurysms].
AB  - We have reported a case of cerebellar hemangioblastoma in a 50 year-old Japanese
      female in which bilateral kidney and ovarian cysts, adrenal adnomatus
      hyperplasia, and erythrocytosis were observed. Futhermore, an aneurysm not
      initially observed was detected by cerebral angiography done 23 months after
      tumor extirpation. We have evaluated the relationship between cerebellar
      hemangioblastoma and concurrent multiple aneurysms with reference to reported
      cases.

PMID- 1036164
TI  - Focus on co-therapy in a rehabilitation programme for advanced schizophrenia.

PMID- 1036165
TI  - The standardization of terminology of lower urinary tract function.
AB  - The terminology of lower urinary tract function will be standardized by the ICS.
      This report contains the recommendations dealing with urinary incontinence,
      procedures related to the evaluation of urine storage (cystometry, urethral
      closure pressure profile) and units of measurement.

PMID- 1036166
TI  - [Neurochemical aspects of corrective effect of fluoracizine in triphthazine
      induced catalepsy in rats].
AB  - Following introduction of triftazine (2 mg/kg) and phthoracizine 8 mg/kg,
      separately and in combination, the intensity of catalepsy, the content of
      dopamine, norepinephrine (fluorometrically), of acetylcholine (biologically) and
      the activity of cholinesterase (calorimetrically) in the caudate nuclei and the
      frontal part of the cortex were determined in rats. It was established that with
      its one-time administration phthoracizine, while keeping down the intensity of
      triftazine-induced catalepsy, prevents, at the same time, the development of a
      number of biochemical effects, viz. there appears a distinctly pronounced
      tendency toward mormalization of the dopamine, acetylcholine levels and of the
      cholinesterase activity. A multiple joint administration of the drugs is also
      attended by lowering the intensity of catalepsy. Then, biochemical changes
      manifest themselves in more complex interrelations.

PMID- 1036167
TI  - Pathoanatomy of the female genital tract of buffaloes.

PMID- 1036168
TI  - Effect of synthetic progestin melengestrol acetate (MGA) on oestrous behaviour of
      anoestrus cattle.

PMID- 1036169
TI  - [Estrus and conception in cattle following cycle synchronization using Estrumate
      (ICI 80996)].

PMID- 1036170
TI  - Leucocyte alkaline phosphatase activity as in index of placental function in
      cases of bleeding during first half of pregnancy.

PMID- 1036171
TI  - Critical closing pressure in the fetal vessel of the human placenta in vitro. II.
      Compared effects of a beta adrenergic substance, Salbutamol, on the critical
      closing pressure and vascular resistance.
AB  - Salbutamol effects upon the fetal vessels of the human placenta were studied in
      vitro, comparing the changes induced upon the critical closing pressure (CCP) and
      viscous resistance (R). Four normal full-term placentas were used. In each of
      them, 4 cotyledonary areas were perfused, thus obtaining a total of 16
      measurements for the observation of spontaneous variations (blank), by perfusion
      with Krebs solution, and the same amount for the variations due to Salbutamol.
      The concentration used was 10 microgram/ml, with a 4.25 ml/min flow. The relative
      effect of Salbutamol upon CCP was its decrease--30.4% against a relative
      spontaneous variation of --3.6%. The mean relative effect upon R was much lower, 
      -9.4%. against a mean relative spontaneous variation of + 3.3%. The advantages of
      using CCP instead of R as a parameter of vascular contractility are discussed.
      Furthermore, Salbutamol is suggested to be useful in improving fetal placental
      circulation.

PMID- 1036172
TI  - Effects of oxamate, an inhibitor of lactate dahydrogenase, upon the spontaneous
      or oxytocin-induced motility and over pyruvate levels of uterine horns isolated
      from ovariectomized or estrus rats.
AB  - The stability with time of the spontaneous as well as the oxytocin-triggered
      functional activity of uterine borns isolated from induced estrus rats and
      immersed in a medium with lactate as the substrate was not affected by the
      presence of oxomate (an inhibitor of lactate dehydrogenase) at 10 or 20mM. On the
      contrary, the oxytocin-driven and the spontaneous motility of preparations
      obtained from 15 days castrated rats diminished significantly following in
      addition of the enzyme inhibitor. Furthermore, uterine borns from ovariectomized
      animals injected with 17-beta estradiol, regain the lack of functional sensivity
      towards oxamate. In addition, determinations of pyruvate levels in homogenates of
      uterine tissue, previously suspended in lactate medium (as in the functional
      experiments), demonstrate to be significantly reduced, following oxamate. Several
      possible reasons, attempting to explain these findings, are discussed.

PMID- 1036173
TI  - A single cannula technique for nonsurgical collection of ova from cattle.

PMID- 1036174
TI  - Postpartum uterine and ovarian changes, and estrous behavior from lactation
      effects in normal and hormone treated ewes.

PMID- 1036175
TI  - Artificial insemination of sheep: the effect of semen diluents containing egg
      yolk on the fertility of ram semen.

PMID- 1036176
TI  - [Cerebral blood flow in Paget's disease of the skull (author's transl)].

PMID- 1036177
TI  - The challenge: PSRO and optometry.
AB  - Professional Standards Review Organizations (PSRO) will be reviewing services
      rendered under Medicare/Medicaid and Maternal and Child Health. The United States
      has been divided into 203 PSRO areas. In states with three or more PSROs, a
      statewide Professional Standards Review Council will be set up. A national
      Professional Standards Review Council advises the Secretary of HEW and Congress
      on the progress of the PSRO program. Norms, criteria and standards will be used
      in the PSRO review process. It is hoped that the PSRO system will be able to
      improve the quality and cost effectiveness of health care being paid for by the
      Federal government.

PMID- 1036178
TI  - PSRO's and optometry.
AB  - Public Law 92-603 is reviewed and reference made to sections where optometry can
      be involved. A guide to the development of a program for inclusion in the PSRO
      program is discussed and a challenge to the profession is issued.

PMID- 1036179
TI  - [Idiopathic cardiomyopathy].

PMID- 1036180
TI  - [Clinical studies of diabetes mellitus].

PMID- 1036181
TI  - [Logic of diagnosis].

PMID- 1036182
TI  - Quantitative analysis of neurosecretory granules in the median eminence of the
      rat during the estrous cycle in the senium.

PMID- 1036183
TI  - Trisomy 9p found in two sibs resulting from maternal translocation.

PMID- 1036184
TI  - Genetic polymorphism of human serum factor B (Bf) in Japanese.

PMID- 1036185
TI  - Discriminatory analysis of dermatoglyphics of hypogonadism.

PMID- 1036186
TI  - [Incidence of XYY in consecutive newborn males in Japan (author's transl)].

PMID- 1036187
TI  - Modifying effects of inactivated bovine serum on the acute toxicity of
      methylmercuric chloride in cells cultured in vitro.
AB  - Dynamics of the killing of Ehrlich's murine ascites tumor cells by methylmercuric
      chloride, MMC, were investigated. Thresholds in the killing action of MMC were
      observed in the MMC treatment concentration, but not in the MMC treatment time.
      Inactivated bovine serum protected the E-cells from killing by MMC in vitro. The
      apparent MMC toxicity was reduced as the serum concentration increased, but
      remaining partially at high concentrations. Thus the serum increases the
      threshold for MMC toxicity. It was confirmed that the mode of action, observed as
      the kinetics of the acute lethality by suspicious substances, could be examined
      promptly on the mammalian cell level by the present experimental system.

PMID- 1036188
TI  - [Endurable grip strength of office workers classified by job and age (author's
      transl)].
AB  - The authors have measured the power and endurable grip strength by five times
      repetition at five second intervals on post-office clerks (indoor service and
      outdoor service) and the personnel of harbor construction office (office workers
      and crew of dredger). The results are as follows: 1) Grip strength (power: higher
      value either at the first or the second grip) has negative correlation with age.
      2) Endurable grip strength (endurance: subtract lower value either at the fourth
      or fifth grip from the grip strength) of the indoor mail clerks and office
      workers has no correlation with age, but that of the others (the outdoor service
      and crew of dredger) has negative correlation with age.

PMID- 1036189
TI  - [Microdetermination of urinary protein for the prevention of occupational renal
      disorders (author's transl)].

PMID- 1036190
TI  - [Studies on the determination of 3,4-dichloroaniline in urine (author's transl)].

PMID- 1036191
TI  - [Analysis of biogenic amines by high speed liquid chromatography (Part I).
      Determination of urinary serotonin with o-phthalaldehyde (author's transl)].

PMID- 1036192
TI  - [Arsenic in biological samples of workers exposed to arsenic trioxide (author's
      transl)].

PMID- 1036193
TI  - Ricinus communis toxin-mediated inhibition of protein synthesis in cell-free
      extracts of a toxin-resistant variant mouse lymphoma cell line.
AB  - Ricinus communis agglutinin II (RCAII, ricin, toxin) at low concentrations
      inhibits protein synthesis in cell-free extracts, but not in intact cells, of an
      RCAII-resistant mouse lymphoma variant cell line. The concentration dependence of
      the inhibition by RCAII was the same in cell-free extracts of both RCAII
      resistant variant and RCAII-sensitive parental cells, while intact parental cells
      are 250 times more sensitive to RCAII toxicity. The onset of RCAII inhibition of
      cell-free protein synthesis was extremely rapid in both cases, being complete in
      a few minutes. Under these conditions RCAII inhibits protein synthesis in intact
      RCAII-sensitive parental cells, but maximal inhibition requires several hours to
      occur. These results support our previous electron microscopic observations that
      the variant cells are defective in the uptake of RCAII by endocytosis at low
      toxin concentrations.

PMID- 1036194
TI  - [Chorionepithelioma and disgerminoma in a 14-year-old girl].
AB  - A 14-year-old girl was operated on for an ovarian tumour, the size of a human
      head, which was twisted, necrotic, and ruptured. The histopathologic finding was
      chorionepithelioma et dysgerminoma ovarii. The girl died two months and a half
      after the onset of the first complaints. The case is presented with all relevant
      details.

PMID- 1036195
TI  - Changes in the content of serotonin and 5-hydroxyindoleacetic acid in the brain
      in the selection of silver foxes according to behavior.

PMID- 1036196
TI  - [Morphogenetic function of the nuclei in the early development of the common
      freshwater snail, Limnaea stagnalis].
AB  - The early embryos L. stagnalis were placed in the actinomycin solution at the
      successive developmental stages. The permeability to actinomycin was previously
      increased by the pricking through egg capsules. The inactivation of nuclei by
      actinomycin up to the stage of 12 blastomeres resulted in the arrest of
      development at the 22 cell stage. The inactivation of nuclei at the subsequent
      development stages resulted in the developmental arrest at later stages. These
      data suggest that the embryonic development up to the 22 cell stage is provided
      by the nuclear function during oogenesis. The morphogenetic nuclear function of
      the embryo begins at the stage of 12 blastomeres and provides the embryonic
      development beyond the 22 cell stage.

PMID- 1036197
TI  - [Changes in the monoamine content in different parts of hypothalamus depending on
      the stages of the estrous cycle].
AB  - Fluorimetric determination of monoamines in various regions of the hypothalamus
      and at different stages of the estral cycle in rats showed that the serotonin,
      noradrenaline, and particularly dophamine content changed both in the course of
      the cycle and at different time (10, 15 and 18 hours) of the same stage of the
      cycle. Dophamine concentration in the arcuate area--the centre of the tonic
      activity--reached its maximum at 18 hours of the diestrus-2 (D2) and fell to the
      minimum at 10 hours of the proestrus (P). Noradrenaline level in the preoptic
      area increased at 18 hours of the D2 and fell at 10 hours of the P. It is
      supposed that in the hypothalamic regulation of the estral cycle at least two
      monoamines (dopamine and noradrenaline) took part; the trigger role belongs to
      noradrenaline of the preoptic area (the cyclic centre).

PMID- 1036198
TI  - [Effect of L-dopa on the gonadotropic function of the pituitary gland].
AB  - Chronic experiments were conducted on female rats. It was shown that
      administration of noradrenaline precursor l-DOPA in a dose of 20 mg/kg for a
      period  of 2 weeks led to the premature sexual maturation of the sexually
      immature rats, depressed the estrus, but increased the percentage of ovulations
      in adult rats with a normal cycle, restored the ovulation in 50% of rats with
      irregular anovular cycle and altered the correlation of the sexual cycle phases
      and the FSH and the LH level in the hypophysis. Administration of l-DOPA to rats
      with a spontaneous estrus restored the normal sexual cycle and ovulation in them.
      Prolonged administration of l-DOPA; (for 3 to 4 weeks) in a dose of 20 mg/kg and
      also the use of higher doses (100 mg/kg) produced a depressive effect on the
      gonadotropic function of the hypophysis.

PMID- 1036199
TI  - [Change in the estrous cycle of mice under the effect of prostaglandin F2 alpha].
AB  - It was shown that specific reception in female mice to prostaglandine F2alpha
      maturated in the process of ontogenesis since the vaginal reaction and the weight
      of the reproductive organs in the immature female animals failed to alter under
      its effect. In the sexually mature mice prostaglandine F2alpha arrested the
      course of the estral cycle and caused an untimely occurrence of the next estrus
      for a more prolonged time than normal, irrespective of the phase of the estral
      cycle during which it was administered.

PMID- 1036200
TI  - Evaluation of the quality of a soya-bean-protein concentrate by nitrogen balance
      studies with human volunteers [proceedings].

PMID- 1036201
TI  - A defective response to cold in the obese (obob) mouse and the obese Zucker
      (fafa) rat [proceedings].

PMID- 1036202
TI  - An explanation of the paradoxical activities of alpha-retinol [proceedings].

PMID- 1036203
TI  - Psychopharmacological studies on echitovenidine.

PMID- 1036204
TI  - Mammalian fertilization.

PMID- 1036205
TI  - Gyral development of the human brain.

PMID- 1036206
TI  - [Evaluation of the immunogenic properties of the BP2 strain vaccine after aerosol
      administration].

PMID- 1036207
TI  - [Characteristics of the course of swine influenza on swine-breeding farms].

PMID- 1036208
TI  - [Stimulation of the sexual cycle in heifers].

PMID- 1036209
TI  - [Clinical and experimental studies of ureteral impairement associated with
      radiotherapy for cancer of the cervix].

PMID- 1036210
TI  - [Physiological studies on Konnyaku. Part 1. On the nutritive value of Konnyaku].

PMID- 1036211
TI  - [Physiological studies on Konnyaku. Part 2. Hypertensive action of Konnyaku].

PMID- 1036212
TI  - [Clinical study on the effects of Linac X-rays on stomach cancer. Its primary
      effect and a histological observation].

PMID- 1036213
TI  - [Effects of various psychotropic drugs on hyperemotionality of the rat in
      prolonged isolation].

PMID- 1036214
TI  - Development of a drug education training course for school teachers.

PMID- 1036215
TI  - [Comparison of 2 in vitro methods of titration of antibodies neutralizing the
      classic swine plague virus].
AB  - Swine fever virus neutralization have been studied by the following method:
      variable plaque forming units numbers are mixed with a predetermined serum
      dilution. Infectivity is measured before (VO) and after (Vr) neutralization
      reaction. Neutralization index (N.I. = logVo/V) represent the difference between
      the two titers. It had been demonstrated that mass law is a good approximation to
      describe swine fever virus neutralization. So the most useful form in which to
      express the relation between N.I. and dilution logarithm (log D) is NI = NIo--K
      log D (I) where K is the constante corresponding to the slope of neutralization
      curve. A sligh K variation is observed according to immunoglobulin classes
      sharing antibody activity. Average K value is equal to 3. NIO is the NI obtained
      when extrapolating the curve to log D = o. These results have permitted to
      compare the two seroneutralization methods commonly used: "constant serum" method
      and "variable serum" method (determination of serum dilution inhibiting 50% of
      infectivity: D50). From formula (I) the following relation can be obtained: see
      formular. Theoretical and experimental log D50 values were appromaximatively the
      same (difference inferior or equal to 0.3). So D50 can be calculated by both
      methods.

PMID- 1036216
TI  - A preliminary fertility appraisal of exotic cattle herds.
AB  - The fertility of 754 cows and 13 heifers in 4 government and several private
      herds of exotic milk and beef breeds in Uganda were studied using information
      originated from the records of genital examinations conducted during a period of
      15 months. The pregnancy or in-calf rate in these animals ranged between 59.2%
      (private farms) and 85.3% (government farms). The proportion of cows not
      inseminated by three months after parturition varied between 50% (government
      farms) and 92.9% (private farms). The average number of days open was 119.07 to
      249.51 in government farms and 187.43 days in private farms, the index of
      artificial insemination ranged between 1.5 and 3.18. Clinical examination
      revealed that inactive ovaries (52.9%) and normal cyclic changes (24.5%) were the
      main disturbances in cows with fertility problems. A smaller percentage was
      attributed to cystic follicles, endometritis, and others.

PMID- 1036217
TI  - The effect of light stimulus on Pekin ducks in the subtropics. Effect on the
      reproduction.
AB  - Experiments were carried out to study the effect of an extended light period
      (natural, gradual, and abrupt) on the semen characteristics, fertility, and
      hatchability of Pekin ducks. The results obtained can be summarised as follows:
      1. Night feeding has no reliable effect on the semen production and
      characteristics in drakes. Thus, any improvement in the semen characteristics of
      different treated groups compared to the control may be traced back to light
      stimulus only. 2. Light stimulus showed a favourable effect on the semen volume
      and sperm motility, concentration, viability and normality during the two laying
      seasons. 3. Subjection of ducks to artificial light had a favourable effect on
      their fertility and hatchability.

PMID- 1036218
TI  - [The coelom and its lining as organoblastema].
AB  - Dissent in the description of the walls of the serous cavities in the thorax has
      led to an investigation of the origin of these serous walls in man. The
      macroscopical and microscopical observations in human dissected and sectioned
      material not only solved this contradiction, but also suggested, that the
      development of the coelom is a more complicated process than is presumed in the
      literature. On one side our observations are confirmed, on the other side they
      are contradicted. Therefore, we decided to follow the development of the coelom
      conscientiously, step by step. A pilot study of embryonic stages in the mouse
      pointed out that in this laboratory animal very similar processes take place, and
      that in very young stages the coelomic wall consists of epitheloid cells.
      Studying the behaviour of these epitheloid cells in embryonic stages in the rat,
      it appeared that the development of the coelom must not only be looked upon as an
      outgrowth and a modification of a cavity, but as an outgrowth and a modification
      of an organ, which consists of a cavity surrounded by its own specific wall. It
      is evident that the cells of this coelomic wall determine the outgrowth and the
      modification of this coelomic organ, which can be considered as a blastema for
      various organs in the thorax.

PMID- 1036219
TI  - [The azygos system].
AB  - The great variety of anatomical dispositions of the azygos system explains its
      facility of adaptation. The second lumbar vein is able to play a buffer role
      between the caval systems or, conversely, is able to direct venous flow to a
      preferential system. In case of portal hypertension, an inferior omphalo-azygos
      flow by the right ascending lumbar vein was noticed. Finally, the left venous
      system may either be the major element of the azygos system (mainly by a big
      ascending lumbar vein) or be divided in 2 distinct streams to the azygos venous
      trunc. The final disposition of the azygos system seems to correlate well with a
      progressive evolution towards an unique trunc, linking directly the two caval
      systems (this being confirmed by foetal data). Practically, the study of the
      arterial and venous relations of the azygos crossing have interesting
      applications in surgery.

PMID- 1036220
TI  - Health planning--unresolved questions.

PMID- 1036222
TI  - National PSRO council: a physician forum.

PMID- 1036221
TI  - Quality assessment: a growing reality in medical practice.

PMID- 1036223
TI  - [Occular injuries from dog bites].

PMID- 1036224
TI  - [H1- and H2-receptor sensitivity to 3-(beta-aminoethyl)-1,2,4-triazole
      derivatives].
AB  - Histamine-like derivatives of 3-(beta-aminoethyl)-1,2,4-trizole were synthetized
      and subjected to a pharmacological study. The sensitivity of H1- and H2-receptors
      to these substances was defined by the following tests, viz. in the isolated
      uterus of a rat, on the isolated atrium of a guinea pig and measurements of the
      blood pressure nn a cat. The derivative 3-(beta-aminoethyl)-5-amino-1,2,4
      triazole (IEM-813) affects predominantly H1-receptors, while 3-(aminoethyl)-5
      amino-1,2,4,triazole (IEM-759) has the closest affinity for H2-receptors, The
      authors presume that corresponding zones of histamine recpetors differ in their
      lyophilic and hydrophilic properties.

PMID- 1036225
TI  - Skin temperature as an indicator of stress in soft tissue.

PMID- 1036226
TI  - Liquid conditioned system for aircraft.

PMID- 1036227
TI  - Thermal balance and thermal comfort in the built environment.

PMID- 1036228
TI  - Development of mobile toilets.

PMID- 1036229
TI  - An instrument for measuring intracorneal adhesion of the stratum corneum of human
      skin.

PMID- 1036230
TI  - The contribution of technology to the management of pregnancy and the first few
      days of extra-uterine life.

PMID- 1036231
TI  - [The antistreptolysin activity of lysozyme].
AB  - The action of O-streptolysin on rabbit red corpuscles is inhibited by lysozyme,
      whereas the enzyme has no effect on termostable cytotoxic fraction of the toxin.
      Moreover little amounts of lysozyme canhance the anti-streptolysinic titers of
      human immune sera. These findings and the relationship between the biological
      activities of O-streptolysin are discussed.

PMID- 1036232
TI  - You can deal with stress.

PMID- 1036234
TI  - The widening scope of the physician-patient contract.

PMID- 1036233
TI  - Maternal nutrition and traditional food behavior in Haiti.

PMID- 1036235
TI  - An assessment of the criteria approach to medical care evaluation.

PMID- 1036236
TI  - The dangerous patient: should the physician warn the endangered?

PMID- 1036237
TI  - PSRO perspective. Nonphysician review.

PMID- 1036238
TI  - Update: PSROs and confidentiality.

PMID- 1036239
TI  - External carotid embolisation--an useful prior adjunct to excision of convexity
      cerebral meningiomas.

PMID- 1036240
TI  - Bilateral anterior internuclear ophthalmoplegia as false localization sign.

PMID- 1036241
TI  - Melatonin inhibition of reproduction in the male hamster: its dependency on time
      of day of administration and on an intact and sympathetically innervated pineal
      gland.
AB  - The daily s.c injection of 25 microgram melatonin (MEL) in oil into adult male
      hamsters at 7 p.m. (lights on 6 a.m. to 8 p.m.) for 50 days caused involution of
      the tests, coagulation of gland and seminal vesicles and depression in pituitary
      prolactin (Prl) levels. Similar injections of MEL given at 9 a.m. completely
      failed to cause regression of the sex organs or a depression in pituitary Prl
      levels. Injections of MEL in the p.m. were completely ineffective in inhibiting
      either the growth of the gonads and adnexa or the pituitary Prl levels if the
      animals had been pinealectomized. Likewise, superior cervical ganglionectomy,
      decentralization of the superior cervical ganglia and anterior hypothalamic
      deafferetation, procedures which interfere with the sympathetic nerve supply to
      the pineal gland, negated the ability of p.m. MEL injections to inhibit
      reproduction in male hamsters. The results indicate that daily MEL injections are
      capable of suppressing reproductive physiology in male hamsters, but only when
      the indole is injected late in the light period, in this case, 13 h after light
      on. The findings also illustrate that daily p.m. MEL injections can inhibit
      reproduction only in animals that have an intact and sympathetically innervated
      pineal gland.

PMID- 1036242
TI  - Quantitative histochemical studies of the hypothalamus. Dehydrogenase enzymes
      during the estrous cycle.
AB  - Three enzymes selected as representative of major metabolic pathways (malic
      dehydrogenase, of the citric acid cycle, lactic dehydrogenase, of glycolysis and
      glucose-6-phosphate dehydrogenase, of the pentose pathway) were measured by
      quantitative histochemical methods in individual hypothalamic nuclei during the 5
      day estrous cycle of adult rats. Malic dehydrogenase increases significantly from
      low proestrous levels to a peak at estrus and then declines during diestrus in
      the following nuclei and areas of the anterior hypothalamus: medial and lateral
      preoptic, suprachiasmatic, supraoptic, and anterior. Significant peaks of lactic
      dehydrogenase occur more often during diestrus-3 in hypothalamic nuclei of the
      middle and posterior hypothalamus, Glucose-6-phosphate dehydrogenase has a
      biphasic pattern with peaks usually occurring during the diestrous period.

PMID- 1036243
TI  - Effects of castration on entrainment of the peripheral corticosterone rhythm in
      rats before and after puberty.

PMID- 1036244
TI  - Argon and xenon photocoagulation in the treatment of diabetic retinopathy.

PMID- 1036245
TI  - [Labeled mitoses curve in different states of cell proliferation kinetics. 2.
      Mathematical model with the calculation of transient processes].
AB  - The available information about the temporal patterns of labelling and mitotic
      indices in the same system has been used to develop a general approach to the
      mathematical simulation of labelled mitoses curve. Such states of cell
      proliferation kinetics as induced DNA synthesis, steady (in narrow sense) state
      and diurnal rhythm of proliferative processes are investigated in a greater
      detail. The principle of a mathematical description of an additional DNA
      synthesis stimulation coming from the states under consideration is also
      discussed in this work.

PMID- 1036246
TI  - [Relationship between the proliferation waves of the hepatocytes after
      hepatectomy and the waves of diurnal rhythm of mitotic activity. 1. Dependence of
      the form of the mitotic wave and the time of attaining its maximal degree on the
      time of operation].
AB  - The diurnal rhythm of mitotic activity (MA) of intact animal hepatocytes and the
      proliferative wave of hepatocytes after partial hepatactomy at time t0 are
      thought to appear as a result of formation of an initial proliferative wave, Pk
      wave, within the G0-phase at constant moments of the day--time
      tk+1=tk+TMA(TMA=24hrs/K, k=1, or 2, . . ., or K) under the influence of the
      regulating system of the organism. Cells of the Pk-wave pass during a short time
      deltat (deltat less than TMA) from the G0-phase into the transformation phase,
      and then into the G1-phase. The 1st stimulated proliferative wave is formed at
      time tk, if tk--TMA less than t0 less than or equal to tk; its intensity depends
      most likely on the intensity of the corresponding Pk-wave of the intact liver. 
      It was noted that time t0 of partial hepatectomy was necessary to coordinate with
      tk, but not with the time of the maximal mitotic activity, and that it was
      necessary to hepatectomize all animals within the interval from time tk--TMA to
      time tk. The model was shown to compare well with data by Post et al. (1963),
      Barbason (1970), and Van Cantfort and Barbason (1972) for hepatocytes of Wistar
      rats with TMA=8hrs, and tk (k=1,2,3) within intervals (2 a.m.; 4 a.m), (10 p.m.;
      noon), and (6 p.m. 8 p.m.). The maximal rate of liver generation was observed for
      all the hepactomized animals with the time of operation being between 8 p. m. and
      2 a.m.

PMID- 1036247
TI  - [Temporary organization of the processes of cell reproduction in the HeLa
      culture].
AB  - Rhythmical changes of the DNA--synthesizing and dividing cells have been
      identified in Hela cultures in the stationary phase of the growth. The periods of
      these changes were not equal to 24 hours. Synchronous quantitative changes of the
      DNA-synthesizing and dividing cells and the similarity in the length of their
      frequency periods were observed. The parameters of culture mitotic cycle: T--27-
      31 hr, tG2min--2hr, tG2+1/2M--4hr, ts--11 hr, tG1+1/2M--12--16 hr.

PMID- 1036248
TI  - [Disorders of sexual function and changes in sex hormones in men with chronic
      liver diseases].

PMID- 1036249
TI  - [Intracellular uptake, distribution and protein binding of androgens in
      experimentally damaged rat liver and kidney].

PMID- 1036250
TI  - [Neurogenic symptoms for the early diagnosis of adverse drug effects].

PMID- 1036251
TI  - Electrical activity of dog myometrium in vivo.

PMID- 1036252
TI  - Faculty salaries in colleges of pharmacy: 1975-1976.

PMID- 1036253
TI  - Training in educational techniques for future pharmacy educators.

PMID- 1036254
TI  - Significant issues raised by the Study Commission on Pharmacy report--an
      educator's perspective.

PMID- 1036255
TI  - Evaluation: from idea "A" to issue "Z".

PMID- 1036256
TI  - [Critical periods in the development of spurs in light of the theory of
      phylembryogenesis].
AB  - Two critical periods have been established in the development of spurs
      representing a derivative of the corneous squama. During the first period the
      exposure to x-rays results in the development of the corneous squama instead of
      the spur, and the same exposure during the second critical period completely
      suppresses the development of the spur. These periods seem to correspond to the
      truning-points in the chain of morphogenetical processes of the spur formation
      associated with phylembryogeneses. Department of Embryology, Institute of
      Experimental Medicine, USSR Acad. Med. Sci., Leningrad.

PMID- 1036257
TI  - [Diurnal biological rhythms in the cells of granulation tissue in a liver
      injury].
AB  - Under study were the diurnal biological rhythms in 37 young mature male Wistar
      rats and in 44 young mature female Wistar rats in the cells of the granulation
      tissue (fibroblasts) 4 and 9 days respectively after injuring the liver. The
      animals were killed in groups every 4 h during 1 day, and in the second series-
      during 2 days. The diurnal rhythm was found in the mitotic activity. The first
      peak of mitoses was observed at midday and the second one--at midnight. The
      second peak may be absent. It has been shown autoradiographically that the
      maximum intensive synthesis of DNA took place at 8'clock a. m., i. e. 4th. before
      the appearance of the first maximum of mitoses. The most intensive synthesis of
      proteins and sulphated mucopolysaccharides in fibroblasts took place at 4 p. m.

PMID- 1036258
TI  - [Human anisakiasis in Chile (author's transl)].

PMID- 1036259
TI  - [Chilomastix sp. in domestic geese in Chile (author's transl)].

PMID- 1036260
TI  - [Renin-angiotensin-aldosterone system in rats with neurogenic stress].
AB  - A moderate neurogenic stress was induced in adult male rats by crowding for a
      period of 1 and 7 days. The content of angiotensin I and the activity of renin in
      the blood plasm aldosterone concentration in the peripheral blood plasma
      considerably. Seven days after the beginning of the neurogenic stress the content
      of aldosterone in the blood plasma considerably. Seven days after the beginning
      of the neurogenic stress the content of aldosterone in the blood and the adrenal
      tissue was determined radioimmunologically. Crowding of rats for 24 hours led to
      a marked increase of aldosterone content in the adrenal glands, failed to alter
      the content of this hormone in the blood, decreased the activity of renin and
      angiotensin I content in the blood and the adrenal glands of rats proved to fall;
      as to the activity of renin and the amount of angiotensin I in the peripheral
      blood plasma - it rose. The problem on the causes of dissociation observed in the
      renin-angiotensin-aldosterone system in response to the neurogenic stress of
      various duration is discussed.

PMID- 1036261
TI  - [Physiopathology of primary glaucoma].

PMID- 1036262
TI  - [Fluorescence angiography of the glaucoma papilla].

PMID- 1036263
TI  - [Subjective examination methods in glaucoma diagnosis].

PMID- 1036264
TI  - [Anatomy and pathology of the aqueous-humor-producing and draining system].

PMID- 1036265
TI  - [Pharmacological principles of glaucoma therapy].

PMID- 1036266
TI  - [Diagnosis and differential diagnosis, conservative and surgical treatment of
      acute glaucoma].

PMID- 1036267
TI  - [Diagnosis and differential diagnosis of chronic glaucoma simplex and chronic
      congestive glaucoma].

PMID- 1036268
TI  - [Conservative and surgical therapy of chronic glaucoma simplex and chronic
      congestive glaucoma].

PMID- 1036269
TI  - [Cooperation between general practice and clinical medicine in glaucoma therapy].

PMID- 1036270
TI  - [Tonometry].

PMID- 1036271
TI  - [Drugs and development of glaucoma].

PMID- 1036273
TI  - [Pressure tests and tonography].

PMID- 1036272
TI  - [Fluorescence angiography of the iris in primary glaucoma].

PMID- 1036274
TI  - [Technic and indications of treatment of retinoschisis with argon laser
      photocoagulation].

PMID- 1036275
TI  - [Photocoagulation in the treatment of retinoschisis. Indications and technic].

PMID- 1036276
TI  - [Treatment of retinoschisis with photocoagulation].

PMID- 1036277
TI  - [Results of photocoagulation treatment of bullous retinoschisis].

PMID- 1036278
TI  - [Treatment with argon laser photocoagulation in occlusions of the retinal venous
      branches. Indications, technic, results].

PMID- 1036279
TI  - [Optic and electronic microscopic study on the human retina of an argon laser
      coagulation after 3 days with rupture of the internal border].

PMID- 1036280
TI  - [Ocular complications of zona ophthalmica].

PMID- 1036281
TI  - [Treatment of various maculopathies by inter-papillo-macular argon laser
      photocoagulation].

PMID- 1036282
TI  - [Indications and limits for argon laser photocoagulation in serous detachment of
      the pigmented epithelium].

PMID- 1036283
TI  - [Macular diseases. Discussion].

PMID- 1036284
TI  - [Our experience with argon laser in the treatment of retinal tears. Analytic
      study of 80 cases].

PMID- 1036285
TI  - Congenital retarded myelinization in a new-born child with infantile spasms.
AB  - A new-born child with frequent infantile spasms was investigated. In a cachectic
      state it died at the age of 11 months. Biopsy of the cerebral cortex revealed a
      retarded myelinization; at autopsy this slight myelinization was found again. The
      ganglioside pattern suggested a developmental stage of approximately 3 months
      before birth. This is a case with a congenital failure of myelinization.

PMID- 1036286
TI  - Mitosis and cytokinesis in the dinoflagellate Amphidinium carterae.
AB  - Mitosis and cytokinesis are described in the free-living dinoflagellate,
      Amphidinium carterae Hulburt. In prophase, invaginations of the nuclear envelope
      form into tunnels which enclose bundles of microtubules. No centrioles or spindle
      organizers are present but microbodies are situated at the ends of the bundles of
      microtubules. The dividing chromosomes are attached to the tunnels, and
      microtubules connect to the nuclear envelope adjacent to the chromosomes by means
      of kinetochore-like structures. At anaphase, daughter chromatids are pulled apart
      as the nucleus extends but there is little change in the pole to chromosome
      distance. Cytokinesis is brought about by pinching-in of the cytoplasm adjacent
      to the equatorial region in an area where many microtubules lie under the
      plasmalemma. The account adds further details to the earlier descriptions of
      mitosis in other dinoflagellates.

PMID- 1036287
TI  - Scanning electron microscopy of the ova of Schistosoma haematobium and
      Schistosoma mansoni.
AB  - Ova of Schistosoma haematobium and Schistosoma mansoni were studied with the
      scanning electron microscope. Observations on the microsculpture, the excretory
      groove on the spine, and the mode of miracidial hatching are discussed.

PMID- 1036288
TI  - Transurethral or endoscopic ureterectomy.
AB  - A technique of ureterectomy performed endoscopically in 5 cases, following nephro
      ureterectomy for pelvic papillomatosis, without evident ureteric involvement, is
      described. This technique for its simplicity, speed of execution and innocuity,
      proved to be of practical utility.

PMID- 1036289
TI  - The mechanisms of appearance of viral glycoproteins at the cell surface membrane.

PMID- 1036290
TI  - Hormone receptor levels and hormone, RNA and protein metabolism in the genital
      tract during the oestrous cycle in the ewe.

PMID- 1036291
TI  - Studies of the composition of human uterine rinsings.

PMID- 1036292
TI  - [Problems in the genetics of stress. I. Genetic analysis of the behavior of mice
      in a stressful situation].
AB  - Behavior of progeny of complete diallel crossing between 4 inbred strains of mice
      (BALB/c, C3H/He, C57BL/6, AKR/J) in a stressful situation was studied. As a model
      of stressful situation, the open field test was used. A statistically significant
      influence of genotype on the variability of the behaviour characteristics is
      found. On the basis of analysis of general combining ability of the strains, a
      hypothesis is made that in the gene pool of BALB/c and C3H/He strains there are
      concentrated some genes of additive effect, which increase the strength of
      emotional reactions of mice in a stressful situation, while in the gene pool of
      C57BL/6 and AKR/J there are genes of opposite effect. An analysis of the specific
      combining ability demonstrates that an important role in the control of features
      characterizing the exploratory activity of mice is played by non-additive gene
      effects, in particular, the effects of over-dominance. Significant genotypic
      correlations between the rate of sexual maturation of female mice and their
      behaviour in stressful situation were observed. The mice which mature earlier are
      more reactive to the stressing effect of a strange environment.

PMID- 1036293
TI  - [Problems in the genetics of stress. II. Genetic analysis of endocrine gland
      weight in mice under normal conditions and during exposure to stress].
AB  - Relative weight of adrenals, thymus, hypophysis and gonads was studied in female
      mice after 21 days after parturition and in intact males. One group of females
      was stressed during pregnancy, and another group was intact. All these animals
      were a progeny of the full diallele cross of 4 inbred mice strains (BALB/c,
      C3H/He, C57BL/6, AKR/J). On the basis of analysis of general and specific
      combining ability the conclusion is drawn that the relative weight of the
      endocrine glands is inherited additively in females of both experimental groups.
      However, it was found that the size of additive genetic variation for these
      characters in the population of females, which had been stressed during their
      pregnancy was larger, than in the control population. A significant role of non
      additive genes in the determination of these characters was observed in males.
      The degree of hypertrophy of adrenals and lysis of thymus in stressed females
      corresponded to their emotional reactivity. Significant genotypic correlations
      between the weight of some endocrine glands, on one hand, and the emotional
      reactivity and the rate of sexual maturation, on the other hand, were found in
      both experimental groups of females. In the stressed group these correlations
      were higher.

PMID- 1036294
TI  - Cytogenetic study in primary amenorrhea.

PMID- 1036295
TI  - Intensity of selection against cleft lip and/or cleft palate.

PMID- 1036296
TI  - A genetic study of schizophrenia pedigree. I. Demographic studies: sample
      description, age of onset, ascertainment and classification.

PMID- 1036297
TI  - The comparative effect of prolonged feeding with raw and heated soybean mean on
      the growth response, pancreatic enlargement and pancreatic enzymes of chicks.
AB  - Prolonged feeding of chicks with raw soybean meal as the main protein source in
      the diet resulted in growth inhibition, pancreas enlargement, and increased
      content of pancreatic proteolytic enzymes. The effect of feeding with raw soybean
      meal as compared to heated soybean meal upon total intestinal enzymatic
      activities in chicks was tested. The tendency of chicks to overcome the effects
      of raw soybean meal is expressed mainly by the increase of biosynthesis and
      secretion of proteolytic enzymes in the pancreas.

PMID- 1036298
TI  - [Demonstration and characterization of an in-vitro renin-secretion stimulating
      serum factor in the rat].

PMID- 1036299
TI  - Metabolic acidosis, nitrogen balance and weight gain in preterm infants.
AB  - Nitrogen balance, urinary NAE and the acid base parameters in the blood of 15
      male preterm infants with birth weights of 1000--2370 g (mean 1715 g) and
      gestational age of 29--37 weeks (mean 33.3 weeks) were determined weekly, in the
      first six weeks of life. The sum of NAE plus acid retention, as "total acid", was
      used to investigate the relationship between nitrogen balance, weight gain and
      acid-base homeostasis. During the first three postnatal weeks, nitrogen intake,
      urinary and faecal loss of nitrogen as well as the nitrogen retention were
      rapidly increasing. Later, urinary excretion continued to rise, the intake
      remained unchanged and as a result, the amount of retained nitrogen decreased
      slightly. Urinary NAE was steadily increasing to reach the maximum of 2.8 mEq/kg
      by the fourth week. Acid retention was the most pronounced in the second and
      third week, thereafter it fell until the end of the study. The importance of NAE
      relative to acid retention was continuously increasing throughout the observation
      period. The "total acid" increased gradually and reached its peak value in the
      third week of life. Subsequently a continuous fall was seen. During the first
      three weeks of life there was a significant positive correlation between "total
      acid" and nitrogen intake and urinary nitrogen extraction. Since the increase in
      "total acid" went parallel with the increasing nitrogen retention, the latter may
      be assumed to be an additional factor in producing acidosis. Calculated per 100
      mg nitrogen ingested, retained or excreted with urine, "total acid" was
      decreasing with the increasing rate of weight gain. This indicates that the
      growth process -- irrespective of the postnatal development of renal H+ handling 
      - is also involved in the elimination of acids.

PMID- 1036300
TI  - New inhibitors of dopamine beta-hydroxylase.

PMID- 1036301
TI  - An integrated approach to instruction in pharmacology and therapeutics.

PMID- 1036302
TI  - [Ultrastructure of spermatogenesis and spermatozoa of Emallagma cheliferum Selys,
      1875 (Coenagrionidae: Odonata)].
AB  - The spermiogenesis in Enallagma cheliferum follows the  usual patterns of
      differentiation in insects. Thus, the Golgi originates the acrosome; the
      "nebenkern", the mitochondrial structures that form a long tail with the axonema.
      The axonema has the configuration 9 + 9 + 2 and around the centriole a centriole
      adjunt is visible in the immature spermatide. The centriole adjunt differentiates
      into dense bodies as a "demi-lune" shape in the mature sperm.

PMID- 1036303
TI  - Some observations on the relationship of Schistosoma haematobium with its
      intermediate host.

PMID- 1036304
TI  - [Significance of ophthalmologic symptoms in acute skull-brain injury].

PMID- 1036305
TI  - [Orbitocranial impalement injuries with the orbit al-aper syndrome in a small
      child].

PMID- 1036306
TI  - [Purtscher's disease].

PMID- 1036307
TI  - [Ophthalmodynamometric study in patients following head injuries].

PMID- 1036308
TI  - [Malignant hyperpyrexia--an unusual anesthesia-incident].

PMID- 1036309
TI  - [General principles in ophthalmological expert testimony following skull-brain
      injuries].

PMID- 1036310
TI  - [Head injury from the rhinosurgical point of view].

PMID- 1036311
TI  - [Fractures of the middle face with reference to involvement of the orbit].

PMID- 1036312
TI  - [Ophthalmologic diagnosis and therapy after skull-brain injuries].

PMID- 1036313
TI  - [Course of accident-induced abducent-nerve paresis in a child].

PMID- 1036314
TI  - [Use of a synoptometer in the differential diagnosis and postoperative course
      control of so-called blow-out fractures].

PMID- 1036315
TI  - [Traumatic oculomotor paralyses and their treatment].

PMID- 1036316
TI  - [Direct and indirect sequelae of injuries to the visual pathway in head
      injuries].

PMID- 1036317
TI  - [Ophthalmological findings in space-occupying processes of the orbit as an
      indication for the utilization of special examination methods].

PMID- 1036318
TI  - [Histological diagnosis in space-occupying processes of the orbit].

PMID- 1036319
TI  - [Roentgenologic diagnosis of space-occupying processes of the orbit].

PMID- 1036320
TI  - [Computer-tomography of the orbit].

PMID- 1036321
TI  - [Ultrasonic diagnosis of space-occupying processes of the orbit].

PMID- 1036322
TI  - [Clinical significance of electromyography in space-occupying and inflammatory
      orbital processes].

PMID- 1036323
TI  - [Retinoschisis and its treatment].

PMID- 1036324
TI  - [Densitometric study of tumors of the anterior optic tract and orbit (Acta
      Scanner)].

PMID- 1036325
TI  - Specific associations of prokaryotes with symbiotic flagellate protozoa from the
      hindgut of the termite Reticulitermes and the wood-eating roack Cryptocercus.

PMID- 1036326
TI  - Absence of hyperactivity in lead-exposed developing rats.
AB  - It has been reported that postnatal lead treatment produces hyperactivity in
      rodents. Using rats, we attempted to extend these findings. Locomotor activity of
      offspring of lead-intubated and pair-fed control mothers was measured at 24-27
      days of age, and no significant differences in reactivity or basal activity were
      found. Observational scoring of the animals at 28-29 and 35-36 days of age
      indicated that active behaviors were slightly reduced in the lead-treated rats.
      The brain lead concentrations of experimental animals were slightly reduced in
      the lead-treated rats. The brain lead concentrations of experimental animals were
      significantly elevated over controls. Estimates of statistical power indicated
      that behavioral effects of the magnitude reported in the literature would likely
      have been detected. The present results indicate that low-level lead exposure may
      not reliably produce hyperactivity in rodents. A review of the literature
      suggests that other data provide little support for a recently proposed rodent
      model of hyperactivity in children.

PMID- 1036327
TI  - Observation of the freeze-drying process of biological materials with a scanning
      electron microscope.
AB  - Over the past few decades, numerous studies have been done on the freeze-drying
      of biological materials from a physical, chemical and biological point of view.
      Morphological observation of the freeze-drying process of specimens, however, has
      been tried by only a few investigators. In those studies, thin-layered aqueous
      specimens, which were sandwiched between two cover slips, were mostly observed
      with an optical microscope. For ultrastructural and stereoscopic observation, the
      scanning electron microscope has a great advantage, unlike that of the optical
      microscope. A specially designed cryo-scanning electron microscope, employed in
      the present study, made it possible to observe the freezing patterns of the
      specimens and also the sublimation process of ice in frozen specimens under
      vacuum. With this specially designed microscope, shrinkage of some specimens due
      to dehydration during the freeze-drying process was revealed and the extent of
      such shrinkage was quantitatively determined.

PMID- 1036328
TI  - An improved freeze-dried bilirubin preparation.
AB  - We describe the conditions for successful freeze-drying of bilirubin solutions in
      the presence of dimethylsulfoxide and human serum albumin. Freeze-dried bilirubin
      preparations rehydrate readily, rapidly resulting in clear solutions. The
      preparations exhibit excellent homogeneity and stability at -20 degrees C.
      Accelerated storage tests indicate that the freeze-dried product would also be
      stable at higher temperatures but our results do not permit, at the present time,
      to make accurate predictions regarding the stability at 4 degrees C or 0 degrees
      C. We believe that our approach will permit manufacturers of bilirubin
      calibrators for clinical use to improve the quality of their products.

PMID- 1036329
TI  - Functional representation of ultrasonic vocalization evoked from rats by
      electrical stimulation of the brain.

PMID- 1036330
TI  - [Reclus' disease--cystic disease on the breast].

PMID- 1036331
TI  - [Idiopathic thrombocytopenic purpura and pregnancy].

PMID- 1036332
TI  - Experimental observations on the integration of bladder and urethral function.
AB  - Bladder and urethral pressure responses to pelvic sympathetic and pudendal nerve
      stimulation in 60 anesthetized cats were studied. Results show that urethral
      resistance is composed of smooth and skeletal muscular components, which relax
      with pelvic nerve stimulation. Reciprocal inhibition of the detrusor-external
      sphincter is a spinal-mediated reflex that can be elicited by pelvic or pudendal
      nerve stimulation. Urethral smooth muscular pressure loss with pelvic nerve
      stimulation can be blocked with propranolol, suggesting that beta-receptors are
      involved in this response.

PMID- 1036333
TI  - The effect of leucocytes on the maturation of mouse oocytes in vitro.

PMID- 1036334
TI  - [Hormonal, histological and karyological study of a case of male phenotype with
      46,XX chromosome pattern].

PMID- 1036335
TI  - Chorionepithelioma of choroid.

PMID- 1036336
TI  - Lead-inducing hyperactivity. Chronic exposure during the neonatal period in the
      rat.
AB  - The effects of chronic exposure to low levels of lead via maternal milk during
      the neonatal period in the rat were evaluated by means of several activity
      measures, spontaneous alternation in the Y-maze, and weight data. Animals reared
      at the highest concentrations of lead showed retarded body growth. Lead-treated
      rats were found to be more active in the Y-maze and in the tilt-box, but not in
      the running wheel. Lead-treated rats showed lowered spontaneous alternation and
      increased squealing; results were dependent upon the concentration of lead on
      which the animals were reared. Activity and alternation data provide suggestive
      evidence of lead-induced damage of the hippocampus, a structure which undergoes
      much of its development during the stage in which the lead was administered.
      Behavioral parallels found between lead poisoning and childhood hyperactivity
      were discussed with respect to the utility of chronic low level lead
      administration as an animal model of minimal brain dysfunction hyperactivity.

PMID- 1036337
TI  - Some behavioral effects of prethcamide compared with those of its two components.
AB  - The effects of the two components of prethcamide (namely crotetamide and
      cropropamide) upon various behaviors in rats were compared with those of
      prethcamide itself to see if both were active or not and the kind of joint action
      shown when they were given in combination. Both crotetamide and cropropamide
      increase the motor activity of rats, reduce the rate of lever pressing in FR and
      VI food-reinforced schedules and increase the latency times in a multiple CRF
      discrimination schedule. When given in combination the drugs show additive
      effects upon locomotor activity and FR or VI behaviors but they potentiate each
      other as regards the effects upon latency times in the multiple schedule. On the
      other hand, a clear antagonism between the two drugs has been found in the acute
      toxicity test.

PMID- 1036338
TI  - The migration of melanoblasts in the extra-epidermal structures of the Silver
      Campine fowl.
AB  - The sequence of time and tracking of melanoblast migration has been worked out
      for Silver Campine fowl. The routes of entry and modes of dispersal of
      melanoblasts into different tissues have been described. The time and condition
      of pigment cell differentiation in extra-epidermal tissues is fully accounted.

PMID- 1036339
TI  - Post ovulatory follicles of the domestic duck.
AB  - Histogenesis of the post-ovulatory follicles in relation to the regression
      process has been studied in the Indian domestic duck. The activities of the
      alkaline phosphatase, acid phosphatase, sudan black-B and periodic acid Schiff
      reaction have been demonstrated histochemically. No lutein cells comparable to
      the mammalian corpus luteum are found. The hypertrophy or proliferation of
      granulosa cells are not observed in this bird. The functional significance of
      different histochemically demonstrable material and steroidogenesis in the avian
      post-ovulatory follicles have been briefly discussed.

PMID- 1036340
TI  - Neuroendocrine control of vitellogenesis in the dragonfly, Orthetrum chrysis
      (Selys) (Odonata: Libellulidae).
AB  - 1. Histological correlative studies on the cerebral neurosecretory cells, the
      corpora allata and the oocyte development strongly suggest the involvement of
      cerebral NSM mostly produced by the A cells of pars intercerebralis and the CA
      hormone in the vitellogenesis. 2. Biochemical studies reveal the incorporation of
      haemolymph proteins and lipids in the yolk during vitellogenesis. 3. Exogenous
      administration of the extract of the brain-CC and FME demonstrates, to some
      extent, the stimulation of protein synthesis during vitellogenesis in the
      haemolymph by the cerebral NSM and the CA hormone, while the lipid metabolism
      lies, mostly, under the control of juvenile hormone.

PMID- 1036341
TI  - Bovine vesiculitis and epididymitis due to feed contamination by Candida
      guilliermondii.

PMID- 1036342
TI  - [Echocardiography in obstructive hypertrophic myocardial disease].

PMID- 1036343
TI  - Fungal flora of conjunctival sac in health and disease.

PMID- 1036344
TI  - Zinc and vitamin A: serum concentrations of zinc and retinol-binding protein
      (RBP) in healthy adolescents.
AB  - The concentrations of serum zinc and retinol-binding protein (RBP) have been
      studied with special reference to pubertal development in 132 healthy adolescents
      and young adults (11-26 years of age). The RBP level remained low during the
      first three of the five stages of puberty (mean, about 30 mg/l). When puberty
      degree 4 had been reached, the mean RBP level increased to nearly adult values
      (about 40 mg/l), the boys having somewhat higher levels than the girls. Use of
      oral contraceptives significantly increased the RBP level. The mean zinc values
      were rather constant throughout puberty, but boys 13-14 years of age had
      significantly depressed values. There was a statistically significant correlation
      between the serum levels of zinc and RBP.

PMID- 1036345
TI  - Persistent chemicals in birds and herbs in Korea.

PMID- 1036346
TI  - [Electron microscopic studies of the gill epithelium of the amphibian teleost
      Periophthalmus vulgaris].
AB  - The gill epithelium of the airdwelling fish Periophthalmus vulgaris has been
      studied with the electron microscope. The following celltypes can be
      distinguished: flat covering epithelial cells, chloride cells, mucous cells,
      basal cells, various leucocytes as well as a specific granule containing cell
      which is possibly an epithelial cell. The covering epithelial cells exhibit a
      relatively smooth apical surface and contain in their apical half densely packed
      microfilaments, pinocytotic vesicles are rare. These characteristics are not to
      be found in water dwelling fish and possibly represent adaptations to the air
      containing surroundings. In the chloride cells are numerous, especially in the
      basal halves of the secondary lamellae. The distal parts of the secondary
      lamellae the barrier for the respiratory gases measures about 0,9 micrometer. The
      basal cells are ribosome rich replacement cells. Two types of mucous cells occur.
      Individual intraepithelial nerve fibres have been observed.

PMID- 1036347
TI  - [The effect of orotic acid and orotic acid derivatives on the in vitro
      differentiation of hippocampus neurons-morphometric and electron microscopic
      studies of ribosomes].
AB  - 1. By means of electron microscopic and quantitative methods at the explantate
      cultures of the fetal hippocampus in vitro the influence of the orotic acid,
      sodium orotate and methylglucamine orotate on the neurogenesis was investigated.
      2. After three days of the in vitro cultivation the neuroblasts influenced by
      these drugs show a smaller respectively not different degree of differentiation
      compared to the controls. 3. Under the influence of the orotic acid and of its
      derivatives the neurogenesis is significantly stimulated. The drugs produce a
      significant increase of the membrane-bound ribosomes and polysomes. The total
      number of ribosomes increases following the application of orotic acid by 20%, of
      sodium-orotate by 48% and of methylglucamine-orotate by 23% compared to the
      controls (alpha = 0,1%). 4. Sodium-orotate shows with reference to the neuronal
      development the clearest stimulatory effect. After 20 days in vitro the total
      number of ribosomes is by 60% higher at the treated cultures than in the
      controls. 5. The results might suggest, that an enlarged supply of the pyrimidine
      nucleotide via a raising of the RNA- and the protein synthesis might stimulate
      the development of the neuroblasts even under the in vitro conditions.

PMID- 1036348
TI  - Analysis of twin data and estimation of heritability effects.
AB  - In a statistical sense, the objective of twin research is to partition the
      variance on some criterion measure among genetic and environmental factors.
      Although certain elaborate models have been developed, these models do not supply
      a convenient test statistic to show which factors make a significant
      contribution. Consequently several procedures drawn from analysis of variance
      have been adapted for use with twin data.

PMID- 1036349
TI  - Genetic studies of the offspring of identical twins: a model for the analysis of
      quantitative inheritance in man.
AB  - In conjunction with full-sib and parental observations, half-sib analysis permits
      an estimation of the genetic and environmental variance as well as a partitioning
      of the genetic variance into its additive, dominance and epistatic components.
      The offspring of identical twins are a unique class of human half-sibs who
      provide an unusual opportunity to resolve and measure several additional
      potentially important sources of human variation including maternal effects, the
      influences of common environmental factors and assortative mating. The genetic
      model thus developed for the analysis of quantitative inheritance in man has been
      applied to the analysis of total ridge count and birth weight, confirming the
      existence of a major additive genetic effect on ridge count and a significant
      maternal effect on birth weight.

PMID- 1036350
TI  - "Equivocalness" and other empirical methods in zygosity assessment.

PMID- 1036351
TI  - The National Heart and Lung Institute twin study of cardiovascular disease risk
      factors: organization and methodology.

PMID- 1036352
TI  - A monozygotic cotwin control study of a treatment for myopia.
AB  - Myopia is the world's most common cause of defective vision. The role of
      controlled accommodation on the progress of myopia is unsettled. This cotwin
      control study is designed to provide a careful appraisal of the effectiveness of
      a clinically acceptable method of controlling accommodation. There are no
      previous reports of similar prospective studies among MZ twins. Expansion of such
      studies would be aided by collaboration among interested investigators.

PMID- 1036353
TI  - Genetic variance in blood pressure.
AB  - The National Heart and Lung Institute Twin Study has examined 514 white adult
      male twin sets aged 42-56 with respect to blood pressure. The data were analyzed
      by a method of Christian et al. which eliminates possible biases in estimated
      genetic variances that could result from different total variances in MZ and DZ
      twins. Results of the test for the presence of genetic variance indicate that
      both systolic and diastolic blood pressure are to a considerable extent
      genetically controlled with an estimated heritability of 0.8 for systolic and 0.6
      for diastolic pressure. Although these findings are at variance with some
      previous reports, it is thought that much of the discrepancy results from
      application of different analytic techniques, not in the data themselves. The
      application of these findings to our understanding of hypertension epidemiology
      and community hypertension control programs are discussed.

PMID- 1036354
TI  - Genetics of plasma cholesterol and triglycerides: a study of adult male twins.
AB  - Fasting plasma triglycerides and cholesterol, as well as cholesterol in very low
      density, low density and high density lipoproteins, were measured in 250 MZ and
      264 DZ adult male twin pairs. A new method was used to choose an estimate of
      genetic variance. This includes an estimate of genetic variance for use when the
      total variances of MZ and DZ twins are unequal. DZ twins had greater total
      variance for cholesterol. When genetic variance was estimated by subtracting the
      within-MZ-sets mean square from the within-DZ-sets mean square, all of the lipids
      had significant estimates of genetic variance; however, when genetic variance was
      estimated by a method designed to correct bias due to unequal total variances of
      MZ and DZ twins, only triglycerides had significant genetic variance. The
      heritability of plasma triglycerides was calculated to be 0.68.

PMID- 1036355
TI  - Plasma protein variability in MZ twins.
AB  - A previous study had shown that only MZ twins are easily exchanged by trained
      police dogs. This is certainly due to the superimposability of the biochemical
      basis of body scent. A different approach has now been tried, based on plasma
      protein fractionating procedures. A pilot study has shown that PolyAcrilamide Gel
      Electrophoresis (PAGE) results, as expected, in widely different patterns only in
      DZ twin pairs. Plasma specimens from a sample of 55 supposedly MZ twin pairs were
      analysed by PAGE. The substantial superimposability of MZ cotwin patterns was
      confirmed. Analysis of the different fractions indicates the extent of
      environmental variability. Application to zygosity determination is suggested.

PMID- 1036356
TI  - Genetic basis of individual differences in tissue composition.
AB  - A total of 19 pairs of twin adolescent boys, 14 MZ and 5 DZ, were used to
      determine the relative contribution of the genotype to the individual differences
      observed in surface density of muscle, subcutaneous fat, and bone. The cross
      sectional areas of these tissue components were calculated from photographs of
      the upper arm, taken by means of an ultrasonic apparatus. The respective mean
      percentage intrapair difference in MZ and DZ twins was 6.9 and 9.8 for total
      area, 6.6 and 7.8 for muscle, 13.9 and 32.0 for fat, and 6.7 and 31.3 for bone
      tissue. Interindividual variations in bone only could be ascribed to genetic
      differences.

PMID- 1036357
TI  - Dermatoglyphic investigations in twins and siblings.
AB  - The present report describes the preliminary results of an extensive
      dermatoglyphic investigation among 491 pairs of MZ and DZ twins, and sibs of both
      sexes. Paired homolateral comparisons were performed for the determination of the
      degree of discordance for each dermatoglyphic trait and the results were
      presented in a series of histograms. Some of the outstanding points brought forth
      by this study are: (1) different dermatoglyphic traits at different digits or
      palmar areas have different degrees of discordance; (2) in MZ twins the frequency
      of discordance for each trait is constant regardless of sex or laterality,
      whereas in DZ twins and sibs both sex and lateral differences are observed; (3)
      the higher number of significant differences in concordance between the MZ twins
      vs. sibs than between MZ vs. DZ twins suggests that, at least in the female, the
      dermatoglyphics may be affected by changing intrauterine environments.

PMID- 1036358
TI  - Normal and aberrant palmar creases in twins and siblings.
AB  - The present study involving MZ and DZ twin pairs, as well as paired normal sibs,
      was undertaken to investigate further the genetic involvement in the formation of
      normal palmar crease patterns, as well as simian and Sydney patterns. Two
      variations of normal creases were investigated: the thenar type R and the distal
      type I. Both types cluster in families. The R is more frequent in the females.
      For both types, MZ twins are more concordant than DZ twins or sibs. Sib studies
      suggest strong genetic involvement in the development of both the R and I crease
      types. Parents with simian and/or Sydney creases have more children with these
      traits than offspring of parents without these traits; however, concordance rate
      comparisons of MZ or DZ twins and sibs do not suggest strong genetic involvement
      as in the case of the R and I crease types.

PMID- 1036359
TI  - Genetic penetrance from MZ twins of absent C-triradius, a palmar dermatoglyphic
      trait.
AB  - Among 59 sets of MZ male twins and 48 sets of MZ female twins from Italy, 7 male
      sets (11.9%) and 7 female sets (14.6%) had absent c-triradius on one or more
      palms; among 214 individuals who had a MZ twin, 19(8.9%) had absent c-triradius
      in one or both palms. Due to small numbers these percentages are comparable to
      the occurrence of absent c-triradius found in 8.2% of 3946 Caucasians. When one
      member of a set of MZ twins showed the trait in one or both palms, 35.7% (5/14)
      of the other members also showed the trait in one or both palms. When an
      individual showed the trait in one palm, 26.3% (5/19) of the other palms also
      showed the trait. These two estimates of penetrance combined give an average
      value of 30.3% (10/33) which is comparable to an estimate of 30% found in a study
      of 478 family units in which transmission was compatible with an autosomal
      dominant gene.

PMID- 1036360
TI  - Heritability study on size of the physiologic cup of the optic nerve head: a
      summary report.
AB  - Cupping of the optic nerve head is regarded as one of a triad of diagnostic signs
      associated with glaucoma. This study was undertaken to assess the role of genetic
      factors in determining size of the physiologic cup of the normal optic nerve
      head, as measured by a horizontal cup/disc ratio. This is important to our
      ultimate understanding of the determinants of pathologic change. Horizontal
      cup/disc ratio was estimated in a sample of 37 MZ and 26 like-sex DZ twin pairs
      aged 15 years and older. Differences between MZ and DZ samples with respect to
      intrapair variance and intraclass correlation coefficient were highly
      significant. This finding of high heritability for measurements of cup diameter
      is in contrast to low heritability estimates found in a companion investigation
      on heritability of the effect of corticosteroids on intraocular pressure.

PMID- 1036361
TI  - Twin studies and behavior genetics.
AB  - It is observed that neither the methodology of twin studies nor that of behavior
      genetics in general has been adequately explored in most investigations of human
      behavior. General distrust of genetic methodologies as well as the belief that
      genic disorders are unalterable appear to be salient factors in explaining the
      neglect of those areas by social scientists. A plea is made for putting aside
      biased attitudes that prevent utilization of the best available techniques for
      the study of human beings as distinguished from all other animals.

PMID- 1036362
TI  - Biology of human intelligence.
AB  - The article presents a brief review of the genetic aspects of intelligence as
      measured by IQ tests. The results from family and twin investigations seem to
      agree in as much as high heritabilities for IQ can be calculated. There are,
      however, a large number of insecurities and sources of error which invite to
      criticism. Although, at present, it is justified to assume that genetic factors
      contribute substantially to variations in IQs, it would be premature to claim
      that genetic and other causes of variation could be expressed in precise figures.
      It seems doubtful if this situation could be further improved by continued use of
      IQs in genetic investigations. It should be more profitable to use other
      entities, such as well-defined special abilities, which could be designed
      directly for genetic analyses.

PMID- 1036363
TI  - Nature-nurture and intelligence: the twin and adoption studies agree.
AB  - A large-scale adoption study is underway at the University of Texas where IQ test
      scores are available for over 1200 women who gave up their children for adoption
      immediately following delivery. The adopted children and their adoptive families
      are now being located and tested and, if current trends continue, complete data
      should eventually be available on over 400 families. About half of these families
      will contain two or more adopted children or both adopted and natural children.
      At present, data are available for 89 families. The results are consistent with
      twin data and support a genetic hypothesis. The biological mother-adopted child
      correlation is 0.37 whereas the adoptive mother-adopted child and adoptive father
      adopted child correlations are only 0.22 and 0.04 respectively. There are 59
      pairs of unrelated children reared together in this sample and the IQ correlation
      for these children is only 0.13.

PMID- 1036364
TI  - Psychological follow-up study of twins from birth to five years.

PMID- 1036365
TI  - Twin resemblances in creativity and in esthetic and emotional expression.
AB  - Three sources of observation relevant to the measurement of individual
      differences in emotional and esthetic expressiveness were employed to study their
      heritability by application to a sample of some 60 pairs of young adult like
      sexed twins, approximately evenly divided between male and female and MZ and DZ
      pairs. The sources of observation were objective test performances, trait
      ascription using a standard list of adjectives, and videotaped enactments of mood
      and esthetic performances. Perceptual and esthetic abilities do appear to have
      substantial heritability, although esthetic preferences do not. Heritability is
      also indicated for such adjectives as artistic, inventive, original, and
      independent. Ratings of the videotape performances yielded somewhat ambiguous
      results, due to the presence of a marked halo effect; the most likely
      interpretation congruent with earlier results is that greater MZ twin
      resemblances in social extroversion generated greater resemblances in the
      videotape situation on such other trait-rating variables as creativity,
      naturalness, and dominance.

PMID- 1036366
TI  - The role of genetic factors in the child drawing behavior: a preliminary twin
      study.
AB  - A sample of 27 MZ and 32 DZ twin pairs, aged 6 to 12 years, has been tested with
      the Draw A Family Test. Significantly higher concordance values in MZ than DZ
      twins have been found with respect to some graphic-structural factors (i.e.:
      line, hand pressure, area of the drawing, dimensions of the figures,
      distribution, and shading) as well as with respect to contents factors, such as
      spatial representation and cotwin's valorization. These correlates of personality
      development would thus appear to undergo significant genetic conditioning.

PMID- 1036367
TI  - Heritability of personality and behavior pattern.
AB  - As part of the National Heart and Lung Institute multicenter study of twins, 190
      twin pairs (93 MZ, 97 DZ) residing in California and aged 44-55 years were
      comprehensively studied for all risk factors for coronary heart disease and for
      Behavior Pattern Type A or B. Psychological tests included MMPI, CPI, 16 Cattell
      PF, Gough Adjective Check List (ACL), Thurstone Temperament Schedule (TTS).
      Heritability at statistically significant levels was found only for scales of
      TTS. Twelve scales of ACL and five scales of TTS showed significant correlations
      with Behavior Pattern Type A-B as well as with several risk factors, including
      blood pressure and serum lipids. Multiple regression equations were constructed
      for those characteristics accounting for significant and unique portions of the
      total variance of Type A-B Behavior. The use of certain scales of ACL and TTS may
      provide a new questionnaire for screening purposes in the assessment of Behavior
      Pattern Type A-B.

PMID- 1036368
TI  - Characteristics of the twins of schizophrenics as fallible indicators of
      schizoidia.

PMID- 1036369
TI  - Heredity and environmental factors in the development of psychogenic diseases.

PMID- 1036370
TI  - Embryonic determination of brain programming asymmetry: a neglected element in
      twin-study genetics of human mental development.

PMID- 1036371
TI  - Is Weinberg's method valid?
AB  - Suppose that L like-sexed and U unlike-sexed twins have been observed. Weinberg's
      method estimates the numbers of DZ and MZ twins as DZ = 2U and MZ = L--U. This
      method is based on the assumptions that (1) the sex ratio in DZ twins is 1/2 and
      (2) the sexes of DZ twins are determined independently and with the same
      probability in all parents; in consequence there should, on average, be equal
      numbers of like-sexed and unlike-sexed DZ twins. The first assumption is not
      exactly true, but the necessary correction is negligible. Departures from the
      second assumption would probably lead to an excess of like-sexed over unlike
      sexed DZ twins; in consequence, Weinberg's method would underestimate the numbers
      of DZ twins and overestimate the numbers of MZ twins. The literature on the
      frequencies of like-sexed and unlike-sexed pairs among twins known to be DZ
      through other genetic markers is reviewed. It is concluded that there is no
      evidence of an excess of like-sexed twins among them, and that there is therefore
      no reason to doubt the validity of Weinberg's method. The extension of Weinberg's
      method to estimate the zygosity types of triplets and quadruplets is described;
      it is shown that the resulting estimates agree well with the results of direct
      zygosity determination by blood grouping.

PMID- 1036372
TI  - [Twin studies in clinical genetics: the clinical cotwin method (author's
      transl)].

PMID- 1036373
TI  - Wolf's syndrome in twins -- translocation in the mother.
AB  - A case of MZ twins, both affected by Wolf's syndrome, is described. Their mother,
      of subnormal look and low intellectual level is translocated. The children, born
      with a weight and size much below the average, show a very special morphotype; a
      hook-nose, an an abnormal conformation of the back edge of the nostrils (a
      protrusion in the shape of a horn overhanging the filtrum), hypertelorism,
      microcephaly. Great asynchronism in the maturation of the bones and a
      somatoschisis of the body of the cervical vertebrae are noted. Deletion of the
      short arm chromosome 4 is juxtacentromeric. The study of blood and tissue groups
      corroborates monozygosity. Dermatoglyphs are little abnormal and identical in the
      two children. The mother's family is phenotypically normal. At 19 months of age,
      measuring is still below 4, psychomotor progress is extremely weak, and
      convulsions are frequent.

PMID- 1036374
TI  - Ischemic heart disease in death-discordant twins: a study on 205 male and female
      pairs with special reference to hereditary factors.
AB  - From January 1971 to March 1973 all twin pairs in the Swedish Twin Registry below
      the age of 70, who became death-discordant, were continuously recorded. A total
      of 205 (78%) of the surviving cotwins were examined with respect to different
      manifestation of ischemic heart diseases (IHD) and several "environmental" and
      "biometric" risk factors. Among the death-discordant pairs, the cause of death
      was IHD in 57 pairs and other than IHD in 148 pairs. Analyses revealed that the
      prevalence rate of myocardial infarction, angina pectoris, pathologic Q-wave, and
      ST depressions in connection with exercise, were significantly higher among the
      surviving cotwins whose partners had died from IHD than those whose partners had
      died from other causes. The same trends were seen for most of the risk factors
      measured both singly and in combination, although not very pronounced. The
      results indicate a substantial genetic influence in the development of IHD. The
      genetic influence is possibly transmitted not only through some of the risk
      factors measured, but also through other factors, still unknown.

PMID- 1036375
TI  - Coronary heart disease in male twins: seven-year follow-up of discordant pairs.
AB  - In an investigation in 1967 of about 100 male twin pairs collected from the
      Swedish Twin Register, discordance with respect to the presence of CHD was found
      in 37 pairs of which 19 were MZ. The investigation included physical examination,
      cholesterol measurements, and an interview regarding, among other things, smoking
      habits. In a follow-up study in 1974 -- seven years after the original
      investigation -- all but one of the 37 twins regarded in 1967 as free from overt
      CHD could be traced. Ten of the 36 twins had developed symptoms of overt CHD
      (angina pectoris or infarction); 18 twins were still healthy, 2 had died from
      other causes, and 6 had questionable complaints of breast pains. In a comparison
      of the two groups of twins with and without symptoms of overt CHD, no differences
      were found with respect to blood pressure, serum cholesterol, or smoking habits,
      as presented at the 1967 investigation. It is concluded that none of these
      factors seemed to influence the future development of CHD in twins apparently
      tainted with a heredity for this disease.

PMID- 1036376
TI  - Metabolic research in monozygotic twins with diabetes mellitus: progress report.
AB  - An intravenous and oral glucose tolerance test and an intravenous tolbutamide
      test have been performed in 11 MZ twin pairs, discordant for diabetes mellitus.
      Blood sugar, immunoreactive insulin, and free fatty acids were determined. The
      research aimed at finding out whether prediabetic subjects may show any
      characteristic parameter which could be suggestive of the hereditary disposition.
      Three MZ twins of juvenile diabetics showed a normal blood glucose,
      immunoreactive insulin, and free fatty acids during the glucose and tolbutamide
      loads within a maximum of 10 years observation.

PMID- 1036377
TI  - A genetic study on deaf twins.
AB  - A clinical and genetic study on 25 twin pairs with at least one deaf member was
      performed. Concordance rate of hearing loss was 0.88 in MZ and 0.50 in DZ pairs,
      with an almost complete penetrance (P = 0.94). Consanguinity was found in 32% of
      cases, corresponding to five times the average population rate in Japan.

PMID- 1036378
TI  - Genetic factors in myopia.
AB  - A school population has been screened to locate same-sexed twins with myopia and
      also to compare intelligence test performance of myopic and nonmyopic
      individuals. Augmentation of the twin data by a survey of the world literature
      has led to the identification of a total of 106 MZ twin pairs, 100 of them
      concordant for myopia, as well as 41 DZ pairs, 12 concordant. Myopic students
      score eight points higher on IQ tests than nonmyopes, the entire bell shaped
      distribution curve being shifted to a higher range. The intellectual gain
      precedes in time the development of nearsightedness.

PMID- 1036379
TI  - [A few remarks on an oculistic and orthoptic screening of 61 monozygotic twin
      pairs (author's transl)].
AB  - An oculistic and orthoptic screening has been carried out on a sample of 122
      twins aged 6 to 10 years (31 MZ male and 30 MZ female pairs). A few remarks could
      be made, concerning both twins as such and the heritability of the traits under
      examination. The twins appear to differ from the general population of singletons
      of the same age on account of a lower frequency of ametropia and strabismus as
      well as of a high frequency of epicanthus.

PMID- 1036380
TI  - Congenital malformations in twins.
AB  - Among 1195 twins born in the Collaborative Perinatal Project, for whom
      information was available, 219 (18.33%) were found to have malformations, 179
      (14.98%) single and 40 (3.35%) multiple. The frequency of malformations among
      twins was significantly higher than that among singletons from the same
      population, but the difference was entirely contributed by MZ twins. This holds
      true for both major and minor malformations. The frequency among Negro twins was
      higher than among white, and among male twins higher than among female. Twins had
      more malformations of the central nervous, musculoskeletal, ear, respiratory,
      cardiovascular, and alimentary systems and fewer malformations of the
      genitourinary and integumentary systems than singletons. In a significant number
      of cases when one twin of a pair had a malformation, the cotwin also had a
      malformation though not necessarily the same as that of the first twin.

PMID- 1036381
TI  - The twin condition and the couple effects on personality development.
AB  - Twin psychology has been studied to a very limited extent. Only few remarkable
      peculiarities of the twins' development are known for sure, such as delayed
      intellectual development, language retardation with frequent cryptophasia,
      difficulties and fragility of self consciousness, reduced sociability. These and
      other peculiarities may result from a number of different factors: biological,
      peculiar parental attitude, and especially the twin situation itself, the
      psychology of the twin as an individual being a function of the psychology of the
      twin pair. Twin peculiarities have for a long time been ignored. On the one hand,
      psychology ignored the couple reality (it was a "one-body" psychology), and on
      the other, the twin method classically postulated that twins are not atypical and
      may therefore be used as a test for the general population. As a matter of fact,
      twin psychology opens a new way to science. The twin situation may serve as a
      paradigm for the general study of the couple effect, namely, for the objective
      analysis of personality as a consequence of the relations between self and
      others. For certain traits of personality, it is already known that MZ twins
      brought-up together are significantly less similar than MZ twins brought-up
      apart. In fact, couple effects may mask or considerably reduce genetic factors.

PMID- 1036382
TI  - The process of identity in twins.
AB  - The Blacky Picture Test was administered to a sample of 12 pairs of male MZ
      twins, aged 17 to 19 years, and to an equal number of singletons. A score for 30
      factors was assigned to each protocol. By comparing the scores of the two groups
      using the Mann-Whitney U test, only one significant difference emerged, relative
      to the factor concerned with positive identification and fraternal relationship.
      Twins chose the sibling figure as the identification object significantly less
      often than singletons did. A more qualitative elaboration was undertaken in order
      to interpret this result. From the final data, the precariousness of the sense of
      identity in the twins comes out indirectly in their passive and conformistic
      acceptance of the paternal model. It would seem that the twin is induced by his
      relationship with his cotwin, seen as the origin of this uncertainty as to his
      own identity, to adhere closely to the paternal image.

PMID- 1036383
TI  - Language development in young twins: biological, genetic and social aspects.

PMID- 1036384
TI  - Twinning frequencies in Baden-Wurttemberg according to maternal age and parity
      from 1955 to 1972.
AB  - The decline of the twinning rate in Germany since 1900 is exclusively due to a
      fall of the DZ rate. The analysis of the birth data in Baden-Wurttemberg from
      1955 to 1972 shows that the decline of the DZ twinning rate can be explained only
      to a small extent by the shift of the maternal age-parity distribution towards
      younger mothers and lower parities. It appears reasonable that the greater part
      of this decline is caused by the lessening prevalence of the more fecundable, DZ
      twin-prone women due to the growing influence of family planning. Furthermore, it
      is imaginable that the probability for multiple ovulation is decreased after
      cessation of hormonal contraception.

PMID- 1036385
TI  - Specific language disorders in twins during childhood.
AB  - The delay in the development of the language often found in twins is usually
      interpreted as being strictly connected with the twinning situation and on the
      assumption that a model of verbal, tendentially cryptophasic, communication would
      more easily exist between twins. Two types of language pathology in twins,
      diverging from this classic framework, are presented: (1) Developmental dyslalia
      (or developmental dysarthria); in these cases no abnormality could be found in
      the modality of verbal communication between the cotwin; (2) developmental
      dysphasia; in these cases not only no tendency toward cryptophasia was observed,
      but indeed the verbal communication between the twins was markedly reduced. These
      two types of language disorders, as well as the classic one, are discussed in the
      light of a neurolinguistic interpretation.

PMID- 1036386
TI  - Stuttering and tics in twins.
AB  - A total of 63 twin pairs (22 MZ and 41 DZ), with one or both members affected by
      not organic stuttering and/or tics, have been drawn out of the Mendel Institute's
      twin file. Concordance of stuttering was observed in 10:12 MZ, but only in 2:19
      DZ twin pairs; concordance of tics in 6:10 MZ and in 2:22 DZ twin pairs.
      Stuttering did not come out significantly associated either with other
      disturbances of language or with an IQ under the average; almost always it was
      possible to find out a precipitating factor. Significant relations between
      stuttering and tics could not be stated. Sex ratio, obtained regarding any
      affected subject separately, clearly turned in favour of males both in stuttering
      (32:12) and in tics (27:12). Stutterers and left-handers incidence in the
      families of stuttering subjects appeared significant in comparison with families
      of subjects with tics.

PMID- 1036387
TI  - Intellectual development of twins -- comparison with singletons.
AB  - Analysis of mental and motor tests scores and intelligence test performance of
      twins born in the Collaborative Perinatal Project shows that twins perform more
      poorly than singletons from the same population and that the differences are
      greater in Negroes than in whites. The poor performance of twins relative to that
      of singletons is of complex etiology. It is partly due to poor prenatal
      environment, for twins brought up as singletons perform at the intelligence level
      of twins and not of singletons. It may also be partly due to the higher incidence
      of congenital malformations in twins, especially those of the central nervous
      system. But the performance of twins, relative to that of singletons, tends to
      improve as they get older, at least from 4 to 7 years, suggesting that
      prematurity is also a contributing factor, whose detrimental effects may be
      reversible.

PMID- 1036388
TI  - Psychopathologic problems in twins during childhood.
AB  - Some psychopathologic problems occurring during childhood in twins are discussed
      from the point of view of mental health. On the basis of case history of twins
      affected by neurologic or psychiatric disorders some typical situations have been
      examined: (1) psychopathologic problems arising from perinatal death of the
      cotwin; (2) psychopathologic problems arising from the death of the cotwin during
      late childhood; (3) psychopathologic problems arising in the pair from organic or
      neuropsychaitric event in one of the twins; (4) psychopathologic problems of the
      twins due to disorders of personal identity and the interaction between the
      twins. The cases are analyzed from a psychodynamic point of view, in relation to
      the development of personality in the twins, and from a psychosocial point of
      view, in relation to the cultural stereotype of the twins during the
      socialization process and in the context of parental dynamics.

PMID- 1036389
TI  - [Psychopedagogic counseling for twins and twin families (author's transl)].
AB  - In 1973 the Mendel Institute, within the specialized services it offers to
      Italian twins, instituted psychopedagogic counseling for twins and their
      families. This service is carried out in the intermediate field between
      neuropsychiatry and social work. Cases involving family and social maladjustment
      were referring for counseling. During the academic year 1973-1974, the service
      examined 96 cases, of which 58 involved problems of school retardation and 38
      involved family maladjustment because of changed parent-twin relationships. The
      counseling service aimed at achieving improved family and school relationships by
      means of various therapeutic interventions. The psychopedagogic counseling,
      besides the immediate therapy, has permitted deeper study of maladjustment by
      means of analyses of the twins' condition as a possible additional cause of the
      maladjustment itself. Analysis of the cases in this limited sample would seem to
      indicate an indirect incidence of the twin situation per se (couple effect),
      somewhat emphasized by the family and social environment.

PMID- 1036390
TI  - The threefold cord of Mothers of Twins Clubs.

PMID- 1036391
TI  - A dream come true: the Illinois Organization of Mothers of Twins Clubs.

PMID- 1036392
TI  - [Heredity of twinning in families of monozygotic twins (author's transl)].
AB  - Whereas the existence of some genetic factor underlying the phenomenon of
      twinning is almost generally accepted with respect to DZ twins, no such agreement
      exists with respect to MZ twins. The possible existence of genetic factors
      underlying MZ twinning has been verified through an analysis of segregation in
      the sibships of MZ twins and in those of their parents, carried out on a sample
      of 57 MZ twin pairs (30 M and 27 F). Haldane's a priori method has been applied,
      considering the sample as obtained through a complete and through an incomplete
      ascertainment. The results may lead to cautiously confirm the hypothesis of some
      genetic conditioning of MZ twinning.

PMID- 1036393
TI  - Scope and methodology of twin studies.

PMID- 1036394
TI  - The problem of genotype-environment correlation in the estimation of heritability
      from monozygotic and dizygotic twins.

PMID- 1036395
TI  - [Scanning electron microscopy studies of the internal surface of the vas deferens
      in normal and castrated rats].

PMID- 1036396
TI  - [Hematological effects produced on horses and sheeps pasturing upon Brachiaria
      radicans Napper (Tanner grass) in winter time (author's transl)].
AB  - Hematological studies were developed on two mares and twelve adults castrate
      sheeps of "Ideal" breed. The animals had been on a pasture formed with Brachiaria
      radicans Napper for one and two months respectively. This experiment was
      developed in winter time, so the leaves of the graminea had a yellow-green color.
      Clinical and hematological observations were made weekly. The typical symptoms of
      intoxication failed to present as observed in the former investigation when the
      plant was green (3). The hematological exames showed only for ovines a slight
      anemia, it was also characterized as being macrocytic and hypochromic. Some red
      blood cells with basophillic stippling and the occurrence of anisocytosis was
      observed in the blood of anemic animals, but no methemoglobin and Heinz bodies
      were found. The Brachiaria radicans Napper, had a low level of nitrate (2)
      therefore the animal poisoning must be attributed to another plant component, not
      nitrate as admited in the first hematological study (12).

PMID- 1036397
TI  - [Day and night changes in arterial pressure in hospitalized hypertensive
      patients. Study by means of an intra-arterial microcatheter].

PMID- 1036398
TI  - Fractionation, structure and some properties of yolk granules from unfertilized
      hen eggs.

PMID- 1036399
TI  - Nonhuman primate diploid cells for vaccine production.
AB  - A cell line was established from male rhesus embryonic lung tissue in 1968. Tests
      for adventitious agents at every tenth passage were negative. The cells had
      diploid characteristics, and supported the growth of polio, rubella, and dengue
      viruses. Tests for latent RNA tumor viruses and tumorigenic potential were
      uniformly negative. A small clinical trial with rubella vaccine produced in these
      cells was conducted, and no major adverse reactions were reported. This cell line
      appears to meet all criteria of acceptability for a safe vaccine cell substrate.

PMID- 1036400
TI  - The testing of cell invasiveness in embryonic tissue and in cell culture.
AB  - The subcutis of 11-day-old chick embryos, 15- to 18-day-old mouse embryos and the
      skin muscle tissue of human fetus were stretched on lens paper in a Petri dish
      and seeded with a piece of LED-Widr or HDC cell sheet. Mem + 10% FCS was added.
      After three days incubation the material was fixed, sectioned and H-E stained. In
      the second part of our investigation several cell lines were prepared on cover
      slips. When confluent, the cultures were inoculated with 1-2 drops of cell
      suspension of another cell line. Three days after the seeding of cell suspension
      on the confluent cell sheet the cultures were fixed and stained. It can be seen
      in the organ cultures that LED-Widr cells closely adhere to the embryonic tissue
      which in some places they are invading. In tissue culture examination we found
      that heteroploid cells seeded on a confluent sheet of diploid cells adhered but
      that a diploid cell seeded on epithelial-like heteroploid cells would not adhere.
      The testing of invasiveness in embryonic tissue in organ culture showed that it
      can be a useful model. By seeding suspended cells of fibroblast lines on a
      confluent sheet of heteroploid cell lines their contact inhibition or their
      invasive ability can be determined. The seeding of heteroploid cell lines on
      diploid cell lines can be used as a model for the study of the mechanism of
      invasion into normal tissue and for the in vitro study of invasion inhibiting
      properties of certain substances.

PMID- 1036401
TI  - Production and control of live oral poliovirus vaccine in WI-38 human diploid
      cells.
AB  - Production of live poliomyelitis vaccine in human diploid cells WI-38 can be
      carried out successfully on a continuous basis. Starting at the 8th population
      doubling level it is possible to produce 128 ampoules, each containing 1 ml of
      cell suspension at the 16th level. Each of these cell seed ampoules will yield 85
      bottles each with a surface area of 1400 sq. cm at the production level (P29)
      together with 85 Roux bottle cultures which act as controls. A further passage
      from the control cells yields a sufficient supply of cells for karyology,
      tumourigenicity and other tests. Virus yields of the Sabin strains are rather
      lower than those obtained in primary monkey kidney cells, but this is compensated
      for by the very much lower reject rate. Karyological characterisation is
      undoubtedly the most demanding of the testing procedures both in time and
      expertise. Other tests for contamination, other than bacteriological have yielded
      uniformly negative results. There is urgent need for standardization of the assay
      systems used in different laboratories and there is perhaps a case for the use of
      reference vaccine produced in homogeneic cells.

PMID- 1036402
TI  - Growth characteristics, cytogenetic stability and virus susceptibility of cell
      lines from New Zealand rabbits.
AB  - We have initiated and established over 90 cell cultures from tissues of embroynic
      New Zealand rabbits. These cell lines show a very varied growth pattern when
      compared to cell lines initiated from human embryonic tissues. The type of medium
      used to grow the cells influences the chromosome stability of rabbit cells.
      Cultures initiated from kidney tissue rarely grow more than 10 passages unless
      the medium is supplemented with lactalbumin hydrolysate. In turn, analyses of
      metaphase chromosomes from the kidney cultures, revealed they were aneuploid as
      early as passages 15. Cultures established from skin and lung tissues will remain
      diploid at least 60 passages when grown on Eagle's Basal Medium supplemented with
      10% fetal bovine serum. However, rarely do rabbit cell lines go into senescence.

PMID- 1036403
TI  - The development of rabbit diploid cell lines.
AB  - The authors describe briefly studies on the development of diploid cell lines
      from fetal tissues (origin: four inbred rabbits). Some lines have been maintained
      in continuous serial culture for over three years. The Lung 16 may represent a
      qualifying rabbit diploid cell line when used between cell passages 48 and 100;
      during this period it has shown a minimum deviation from the normal diploid
      rabbit karyotype; it supports the growth of rubella virus, is non-tumorigenic and
      might be useful as a substrate for human vaccine.

PMID- 1036404
TI  - Development of a diploid cell line from fetal calf lung for virus vaccine
      production.
AB  - Details of isolation and replication of a fetal calf diploid cell (FCDC) is
      given. From the karyological point of view, the fairly large number of
      chromosomes existing in metaphase spreads made counting rather tedious. Lack of
      practical classification was another problem which made reference to individual
      chromosomes difficult. By increasing the population doubling of this cell, a
      tendency of telocentric chromosomes to undergo centric fusion was observed.
      Susceptibility of FCDC to different viruses is described.

PMID- 1036405
TI  - The use of foetal, calf and adult bovine sera for the growth of serially
      subcultivated diploid cells.
AB  - Medium CMRL-1969 supplemented with either foetal calf, calf or adult bovine sera,
      or a combination of the various sera, was used to subcultivate diploid cells for
      the preparation of substrates for vaccine production. Supplementation with calf
      or adult bovine sera gave satisfactory cell yields for at least 3-4 population
      doublings. The finite lifespan of the diploid cells grown in media supplemented
      with foetal calf was always longer than with calf or adult bovine sera. However,
      a combined supplement of adult serum plus a low concentration of foetal calf
      serum gave results equally as good as foetal calf serum alone. Sera obtained
      aseptically from adult animals kept in isolation and monitored constantly for
      health are more desirable than sera obtained from abattoirs. Selection of donor
      animals and pooling of certain serum batches were found to be important for the
      preparation of serum supplements. The final protein concentration of the cell
      culture medium should not exceed 0.8% when adult bovine sera are used. For the
      growth of WI-38 or MRC-5 cells the use of foetal calf serum can be reduced or
      eliminated.

PMID- 1036406
TI  - Methods for reducing the serum requirement for growth in vitro of nontransformed
      diploid fibroblasts.
AB  - The amount of serum protein required for clonal growth of normal diploid human
      and chicken fibroblasts has been reduced more than 90% by development of improved
      synthetic media and culture conditions. The following has contributed
      significantly to the reduction: (1) replacement of specific serum proteins with
      defined small molecular nutrients; (2) precise quantitative balance of all
      defined nutrients for optimal growth of single cells of each type under
      consideration; (3) modification of the culture substrate; (4) improvement of the
      cell harvesting technique. By combining these improvements, optimal growth of
      human fibroblasts (fetal lung, newborn foreskin, amniotic fluid) and chicken
      embryo fibroblasts occurs in synthetic media supplemented with 500 microgram/ml
      dialyzed fetal bovine serum protein [equivalent to 1% (v/v) whole serum]. The
      human fibroblasts form large colonies at a suboptimum rate at 25 microgram/ml
      dialyzed serum protein [equivalent to 0.05% (v/v) whole serum] and several
      divisions can be obtained in the complete absence of serum protein. Human and
      chicken fibroblasts differ both in their quantitative requirements for defined
      nutrients, and in the type and number of incompletely characterized serum
      components that they continue to require under the improved growth conditions.
      The improved systems provide a sensitive assay for the remaining undefined growth
      promoting components of serum and other biological extracts.

PMID- 1036407
TI  - [Radiotherapy and treatment of cancer of the prostate].

PMID- 1036408
TI  - [Internal urethrotomy using a special blade. Apropos of 80 cases].

PMID- 1036409
TI  - [Our surgical experience in 3 cases of aplasia of the female urethra].

PMID- 1036410
TI  - [Perfecting of an artificial &sphincter in dogs. Its use in artificial bladder].

PMID- 1036411
TI  - [Usefulness of translumbar percutaneous puncture in the diagnosis and treatment
      of reno-ureteral tuberculosis].

PMID- 1036412
TI  - [Animal-experiment studies on the pathogenesis of peptic ulcer in the newborn].
AB  - Gastric secretion was studied in 188 fetuses of 28 pregnant dogs near term.
      Baseline secretory values were determined and gastric secretion was stimulated in
      additional fetuses with histamine, insulin, or gastrin. A significant increase in
      volume, acidity and pepsin output was observed in fetuses stimulated during the
      last week of gestation. Following maternal stimulation the placental transfer of
      histamine, insulin, and gastrin are demonstrated.

PMID- 1036413
TI  - Delay in the appearance of clamp connection in Schizophyllum commune by
      inhibitors of microtubule protein assembly.

PMID- 1036414
TI  - Angioblastoma of the posterior fossa in childhood.

PMID- 1036415
TI  - Tissue specificity of myocardial glycopeptides synthesized during early embryonic
      development.
AB  - [3H] Glucosamine-labeled glycopeptides synthesized by hearts from stage 14-16
      chick embryos were separated on DE-52 by ion-exchange chromatography and compared
      to those synthesized in other parts of the embryo at the same stage. Relatively
      few molecular species were present in all tissues, and they appeared closely
      homologous. There were no glycopeptides unique to any embryonic region examined,
      suggesting that tissue specificity may result from quantitative rather than
      qualitative differences in glycopeptides.

PMID- 1036416
TI  - Effect of graded coronary stenosis on regional myocardial blood flow and left
      ventricular function.
AB  - Dogs with 70% stenosis of the left circumflex coronary artery showed a reduction
      of myocardial blood flow with a minimal impairment of left ventricular wall
      motion. Eighty to ninety percent stenosis produced a marked reduction of flow and
      wall motion, and ST elevation close to 100% occlusion, but delayed antegrade run
      off was found. The effectiveness of collaterals to protect against left
      ventricular dysfunction was supported.

PMID- 1036417
TI  - Role of acetaldehyde in the pathogenesis of alcoholic cardiomyopathy.
AB  - Rats given both ethanol and tolbutamide showed decreased oxidative
      phosphorylation of the myocardial mitochondria as compared with rats given only
      ethanol. There were no differences in ethanol consumption and blood ethanol
      levels between the two groups. The concentration of acetaldehyde tended to be
      higher in rats given both ethanol and tolbutamide than in rats given ethanol
      alone. It is concluded that acetaldehyde plays a more important role in the
      production of alcoholic cardiomyopathy than does ethanol itself.

PMID- 1036418
TI  - Lowering of blood acetaldehyde levels-a possible approach to prevention of
      alcoholic cardiomyopathy.
AB  - Based on the assumption that circulating acetaldehyde (AcH) is cardiotoxic, D
      penicillamine was administered to dogs given alcohol orally, or given AcH
      intravenously. Paralleling the increase in plamsa norepinephrine (NE) and
      epinephrine (E) induced by AcH infusion, hemodynamic measurements showed a
      positive inotropic response with increase in pulse, blood pressure, left
      ventricular contractility, and cardiac output. Infusion of D-penicillamine
      abruptly lowered circulating levels of AcH and catecholamines, which was
      accompanied by an appropriate hemodynamic response.

PMID- 1036419
TI  - Electrical properties of cultured heart cells.

PMID- 1036420
TI  - Molecular mechanisms in genetic transformation.
AB  - Molecular mechanisms of recombination of genetic material are most readily
      studied in microorganisms; a great deal is known about recombination of
      transforming DNA, introduced into the cell from the medium, with DNA inside
      bacteria. At present it is doubtful that this type of transformation will be of
      use in improving crop plants. However, a new technique of making recombinant DNA
      molecules from two or more highly divergent organisms may turn out to have great
      practical importance for agriculture.

PMID- 1036421
TI  - The infertile couple: evaluation and treatment.

PMID- 1036422
TI  - [Toxoplasmosis as a cause of infertility].

PMID- 1036423
TI  - [Uptake of Mg++ in lymphocytes stimulated with phytohemagglutinin].

PMID- 1036424
TI  - [Action of concanavalin A on phagocytosis].

PMID- 1036425
TI  - [A cholinergic participation in the increase of cerebral cortical blood flow
      induced by vincamine (rat) (author's transl)].
AB  - The effect of vincamine on cortical blood flow was tested in control rats and
      after atropine administration. Cortical blood flow was measured in urethanized
      rats by means of the hydrogen clearance method. A significative increase in
      cortical blood flow and decrease in blood pressure and cortical vascular
      resistance was produced by vincamine iv administration in control animals. In
      atropinized rats significative cortical blood flow changes were not observed
      although some tendency to increase was detected. It is suggested that increase in
      cortical blood flow induced by vincamine may be due to direct action on the
      vascular smooth muscle and, partially, through a cholinergic mechanism.

PMID- 1036426
TI  - Early corpus luteum formation (corpus haemorrhagicum) in a 3--3/12-year-old
      "senile" mouse.
AB  - In a female mouse sacrificed at the age of 3--3/12 years, corpus heamorrhagicum
      and arteric corpora lutea were found in the ovaries, apart from smaller
      follicles. No evidence could be found in the literature for their presence at
      this age. Based on these findings, aspects of basic gerontological research are
      discussed.

PMID- 1036427
TI  - Mechanisms of spontaneous and induced heteroploidization and polyploidization.
AB  - Mechanisms of heteroploidization and polyploidization were studied in tissue
      cultures, using various methods and cell lines. In untreated populations cells
      with different chromosome number are formed by mitotic non-disjunction.
      Mononuclear polyploid cells are formed by repeated DNA synthesis
      (endoreduplication) and polynuclear giant cells by postmitotic fusion of the
      daughter cells. These phenomena occur more frequently in cell populations treated
      with cystostatic drugs. Most polyploid cells are not viable.

PMID- 1036428
TI  - Avian aldolases. I. Comparative study on the purification, structural and kinetic
      properties of chicken and pigeon breast muscle fructose-1,6-diphosphate
      aldolases.

PMID- 1036429
TI  - Effect of different doses of x-ray irradiation on Bulinus truncatus snails and
      eggs.

PMID- 1036431
TI  - The serum opacity reaction of Staphylococcus strains: general properties of the
      Staphylococcus factor (SOF).

PMID- 1036430
TI  - [Noise problems in shipyards and during navigation].

PMID- 1036432
TI  - A study of pharmacologically active factor in the human seminal fluid.

PMID- 1036433
TI  - Effect of L-dopa on pituitary gonadotropic function.

PMID- 1036434
TI  - [Neuropsychological study of long-term cerebral complications of eclampsia
      (author's transl)].
AB  - A review of the literature shows that long-lasting neurological complications of
      eclampsia are rare, but that, when present, they frequently involve visual
      function. Two patients are reported, whose symptomatology suggested damage to the
      posterior region of both cerebral hemispheres. The first patient showed a
      Balint's syndrome with complete inability to perceive more than one object at a
      time, erratic gaze movements and optic ataxia. After a year and half a marked
      improvement was observed. The second patient presented with severe of
      dyscalculia, spatial memory disorders, constructional apraxia and mild aphasia.
      She recovered completely in one year. This symptomatology might result from
      ischemic lesions in the watershed area between the territories of the middle and
      posterior cerebral arteries, the underlying mechanism being the compression of
      the posterior cerebral artery against the tentorium, caused by edema.

PMID- 1036435
TI  - Subcutaneous phycomycosis in India.

PMID- 1036436
TI  - Maduromycotic mycetoma from Pondicherry.

PMID- 1036437
TI  - Intussusception in idiopathic thrombocytopenic purpura.

PMID- 1036438
TI  - Psychophysiologic and psychologic characteristics in twins in reaction to stress
      situations.

PMID- 1036439
TI  - [Levels of testosterone-estradiol-binding globulin TeBG and of testosterone in
      pregnancy with relation to the sex of the foetus (author's transl)].
AB  - A practical and economic method for the quantification of testosterone-estradiol
      binding globulin TeBG is described. The procedure premits the differentiation
      without overlap of the TeBP levels in males, non-pregnant females and during
      pregnancy. Mean titles were 1/5, 1/93 and 1/360 respectively. During pregnancy,
      we found high levels of TeBG and increased plasma testosterone, with mean values
      of 143.4 nanograms/100 ml. We have found no significant differences in TeBG
      levels, or in maternal blood testosterone levels in relation to fetal sex;
      however, plasma testosterone levels were significantly different among new born
      of different sex, with mean values of 96.25 nanograms per cent for males and
      78.21 nanograms per cent for females.

PMID- 1036440
TI  - Effects of stress upon the oxidative metabolism and its correlation with gastric
      ulcer formation: the role of sex.
AB  - The metabolic-oxidative activity of different nervous and glandular structures
      (amygdala, hypothalamus, lateral-frontal cerebral cortex, adrenal glands) in male
      and female rats under acute stress caused by physical immobilization, was
      determined. The sexual cycle of the female rat was controlled by examination of
      their vaginal frotis. One experimental group during estrus and another one during
      diestrus were selected. At the same time ovariectomy was performed on an
      experimental group in order to eliminate the hormonal influences of the ovary.
      Results show there are no significant differerneces in the oxidative metabolism.
      Nor in the numbers of ulcers. Hypothalamus-hypophyseal-adrenocortical activation
      was made manifest on obtaining significant differences in the weight of the
      adrenal glands, a fact long ago reported in a number of studies. Necropsy showed
      severe gastric hemorrhages and ulcer in the stomach. Nevertheless, no significant
      differences between the distinc experimental groups were obtained. The likely
      participation of sexual hormones in female rats is discussed in the light of our
      results.

PMID- 1036441
TI  - Nutritional factors affecting the biosynthesis of retinol-binding protein in the
      liver and its release into plasma.

PMID- 1036442
TI  - Polymerized micelles and their use as adjuvants in immunology.
AB  - A polymerization process is described for the preparation of hydrophilic micelles
      containing solubilized drug molecules in a colloidal aqueous system of dissolved
      monomers. A hydrocarbon medium constitutes the outer phase. After secondary
      solubilization with the aid of selected surfactants, polymerization of micelles
      under different conditions takes place. The formulation of drugs including labile
      proteins in the ultrafine polymer components ("nanoparts") and their isolation
      are possible without noticeable destruction of the encapsulated molecules.
      Entrapped tagged material (human 125I-immunoglobulin G) shows a stable fixation
      in such nanoparts during long-term in vitro liberation trials. Nanoparts are
      visible with the aid of an electron microscope. They are mostly spherical in
      shape and smaller than 80 nm in diameter. They form real colloidal aqueous
      solutions. Nanoparts are suitable to embed antigenic material (tetanus toxoid and
      human immunoglobulin G) for parenteral use. These preparations show intact
      biological activity and high antibody production in animals.

PMID- 1036443
TI  - Reinvestigation of disulfiram-like biological activity of Coprinus atramentarius
      (Bull. ex Fr.) Fr. extracts.
AB  - A ninhydrin-positive aqueous fraction isolated from Coprinus atramentarius (Bull.
      ex Fr.) Fr. showed significant disulfiram-like activity in mice. The isolation of
      the fraction from the mushroom crude extract and a convenient pharmacological
      test for following the physiological activity in each fraction are described.

PMID- 1036444
TI  - D-penicillamine therapy of neonatal jaundice: comparison with phototherapy.
AB  - A total 330 newborns suffering from haemolytic disease of the newborn and
      hyperbilirubinaemia was treated with D-penicillamine. The therapy resulted in a
      significant decrease in the frequency of exchange transfusions and of high serum
      bilirubin levels among preterm and fullterm babies with or without sensitization.
      Concerning the drug's mechanism of action, reduction of the bilirubin level is
      achieved by means of the copper stored in the liver. The intravenous route is
      suggested for application of the drug. In preterm infants D-penicillamine
      treatment proved more effective than phototherapy.

PMID- 1036445
TI  - Morphine withdrawal reactions in male and female mice.
AB  - In the present study we have used the morphine implantation method to investigate
      the intensity of the abstinence syndrome in both male and female Swiss Webster
      morphine-dependent mice. It is evident from our data that naloxone induced no
      significant difference in the jumping behavior of both morphine-dependent male
      and female mice when weight variables were controlled.

PMID- 1036446
TI  - The dilemmas of coordinating treatment with criminal justice.
AB  - Problems the Abraxas Foundation encountered in accommodating therapeutic
      community practices to the justice system in order to develop an alternative for
      courtstipulated drug offenders are reviewed. First, traditional expectations for
      prospective clients' motivation proved to be unrealistic. Second, courts' needs
      for information on their clients' progress appeared to conflict with client
      confidentiality laws. Finally, Abraxas resented what it initially took to be the
      courts' intrusion into program affairs. In response, Abraxas has sensitized its
      staff to the courts' role, established a uniform policy on progress reports,
      promoted communications with external agencies, and emphasized coordination of
      treatment effort with court officials.

PMID- 1036447
TI  - [The diurnal variations of the serum iron level and of the latent iron binding
      capacity in normal rats (author's transl].

PMID- 1036448
TI  - [The relationship between time of day and 59Fe incorporation of red blood cells,
      bone marrow, liver, spleen and kidneys in normal rats (author's transl)].

PMID- 1036449
TI  - Burkitt's lymphoma of the ovary in association with pregnancy. Two case reports.
AB  - Burkitt's lymphoma of the ovary, occurring in association with pregnancy, is
      rare, only one case having been previously reported. Two cases are reported here
      and the possible effect of pregnancy discussed.

PMID- 1036450
TI  - Menstruation per urethram. A case report.
AB  - The case history is presented of a 24-year-old woman who had a uterus duplex,
      grossly underdeveloped cervices, absent vagina and who menstruated regularly
      through a communication between one cervical canal and the urethra.

PMID- 1036451
TI  - [Pereyra's cystourethopexy in the treatment of stress urinary incontinence].

PMID- 1036452
TI  - [Vestibulo-vulvar atresia. Surgical solution].

PMID- 1036453
TI  - [Hypoglycemia and exchange transfusion].

PMID- 1036454
TI  - Argon laser photocoagulation treatment for retinal disease.

PMID- 1036455
TI  - Scanning electron microscopic observation of hatching in some diphyllobothriid
      cestodes.

PMID- 1036456
TI  - [The significance of the isolated epidural hemorrhage in the spinal canal for
      perinatal mortality].

PMID- 1036457
TI  - [Non-pathological coprolalia in early age].

PMID- 1036458
TI  - Purification of interferon by adsorption chromatography on controlled pore glass.
AB  - Human fibroblast and mouse L929 cell interferons can be purified by adsoprtion to
      and subsequent elution from Controlled Pore Glass. Purification of 40 to 90-fold
      to specific activities of 1 to 5 times 10(6) units/mg of protein can be achieved
      in a single step, with good recovery of activity. Human leukocyte interferon does
      not bind to the glass and cannot be purified in this way.

PMID- 1036459
TI  - A new method for assessment of fetal lung maturity.
AB  - A new method for evaluation of fetal lung maturity in utero is described. The
      method is based on the fluorescence polarization (P) of the lipids in the
      amniotic fluid after labelling with a special dye. Tests performed with 49
      amniotic fluid samples drawn from 33 pregnancies clearly demonstrated a decrease
      in P during gestation which correlated with the increase in the
      lecithin/sphingomyelin ratio (L/S) in the fluid. During gestation the P value at
      24 degrees C decreased steadily from about 0-4 to 0-2 and the value of P (24
      degrees C) = 0-310 has been tentatively chosen as the threshold above which
      respiratory distress syndrome may develop. The described method, which requires a
      specially designed instrument, offers a series of important advantages over the
      presently available methods. It is simple, rapid, highly accurate and
      reproducible, and independent of amniotic fluid volume. The P value reflects the
      microviscosity in the whole lipid assembly of amniotic fluid and is not confined
      specifically to lecithin.

PMID- 1036460
TI  - Galactose oxidase: applications of the covalently immobilized enzyme in a packed
      bed configuration.
AB  - Galactose oxidase (E.C. 1.1.3.9) was covalently immobilized to chemically
      modified porous silica particles by reaction of the native enzyme with pendant
      benzoyl azide groups on the carrier. The enzyme loading on the carrier was 100
      150 units per milliliter. The immobilized enzyme was incorporated into a hardware
      assembly suitable for the determination of galactose or lactose concentrations in
      complex biological fluids. The prototype instrument as described is suitable for
      continuous, on-line monitoring or discrete sample analysis. Reaction conditions
      can be readily provided which maintain global first order kinetics within the
      reactor and strict linearity of the procedure over a wide range of sample
      concentrations. Auto-inactivation of the immobilized enzyme can be prevented by
      K3Fe(CN)6 and long-term reactor stability can be achieved by the periodic
      application of the reagent to the enzyme reactor in situ.

PMID- 1036461
TI  - Can hepatitis B be transmitted sexually.

PMID- 1036462
TI  - Baghdad--frontier city of medicine.

PMID- 1036463
TI  - Prolonged eradication of urogenital mycoplasmas after administration of
      tetracycline to men in the Antarctic.
AB  - Meatal swabs were obtained at intervals over 1 year from 23 men in the Antarctic.
      A 5-day course of tetracycline was given to twelve of them. In retrospect it was
      found that the antibiotic had been received by two men who were harbouring
      ureaplasmas, one of whom also had M. hominis. After treatment, these organisms 
      were not found in any of the swabs taken over the next year, except in a swab
      from one of the men following sexual contact after this time. One of the twelve
      men developed N.S.U. just before arriving in the Antarctic. He responded
      clinically to a shorter course of tetracycline and ureplasmas were not recovered
      from a meatal swab immediately thereafter. However, without further sexual
      contact, ureaplasmas and disease recurred about a month later. This time, after a
      5-day course of tetracycline, disease was not seen, and ureaplasmas were not
      isolated, over the next year. In contrast, ureaplasmas were isolated consistently
      over a year from two men who were not given the antibiotic. The evidence strongly
      suggests that, under natural conditions, the most likely cause of mycoplasmas,
      particularly ureaplasmas, recurring in the genital tract after apparently
      adequate tetracycline therapy, is re-infection as a result of sexual re-exposure.

PMID- 1036464
TI  - Shigellosis. Another sexually transmitted disease?
AB  - Following the clinical observation that there appeared to be an association
      between shigellosis and male homosexuality, the medical records of 113 patients
      at The New York Hospital were reviewed retrospectively. Of the 38 males studied
      who were between the ages 19 and 61, seventeen were homosexual (44-7 per cent.).
      Only one of the matched controls was homosexual. Of the men with shigellosis who
      had a history of foreign travel, 10 per cent. were homosexual; however, among the
      patients without a travel history, 57-1 per cent. were homosexual (P less than 0
      05). For male patients with shigellosis who do not have an appropriate travel
      history, the physician should expand his epidemiological investigation to include
      sexual contacts. Men and women who perform rectal intercourse should be cautioned
      to abstain from this activity until their stool cultures are negative for
      shigella. If a male patient with shigellosis is homosexual, he should be screened
      for other sexually transmitted diseases such as syphilis, gonorrhoea, hepatitis
      B, and amoebiasis.

PMID- 1036465
TI  - Successful therapy with methotrexate of a multicentric mixed lymphoma of the
      central nervous system.
AB  - Primary lymphoma of the central nervous system (CNS) is extremely rare. A case of
      mixed histiocytic lymphocytic lymphoma of the CNS that initially occurred in the
      spinal cord is reported. Multicentric recurrence following radiotherapy was
      successfully treated with intrathecal methotrexate and the patient remains free
      of disease after 4 years. The role of intrathecal methotrexate as alternative
      therapy following irradiation failure is discussed.

PMID- 1036466
TI  - Methotrexate pneumonitis induced by intrathecal methotrexate therapy: a case
      report with pharmacokinetic data.
AB  - A patient with adenocarcinoma of the breast metastatic to the leptomeninges was
      treated with 10 doses of intrathecal methotrexate (MTX) administered at intervals
      of 2 days. Following these treatments she developed fever, hypoxemia, and
      bilateral pulmonary infiltrates without documented pulmonary infection. Autopsy
      findings were consistent with the pneumonitis that has been associated with
      intermittent oral, intramuscular, and intravenous MTX therapy. It is suggested
      that this patient's pulmonary process represented MTX pneumonitis following
      intrathecal MTX. Cerebrospinal fluid and serum MTX concentrations determined
      retrospectively on frozen samples reflect an atypically rapid transport of MTX
      from this patient's cerebrospinal fluid to a slowly decaying systemic pool.
      Because of this, serum MTX levels probably exceeded 10-8M during the entire 20
      day course of therapy, thus exposing the pulmonary parenchyma to significant drug
      concentrations for a prolonged interval. It is suggested that these unfavorable
      pharmacokinetics may have contributed to this patient's susceptibility to MTX
      pneumonitis.

PMID- 1036467
TI  - A comparison of cyclophosphamide, vincristine, and prednisone (COP) with nitrogen
      mustard, vincristine, procarbazine, and prednisone (MOPP) in the treatment of
      nodular, poorly differentiated, lymphocytic lymphoma.
AB  - This study was designed to test the efficacy and toxicity of COP
      (cyclophosphamide, vincristine, and prednisone) and MOPP (nitrogen mustard,
      vincristine, prednisone, and procarbazine) in 13 previously untreated patients
      with disseminated, nodular, poorly differentiated, lymphocytic lymphoma, and to
      test for patient cross-resistance to the regimens. Complete remission was
      initially achieved in six of eight patients on COP and three of five on MOPP.
      Three patients were crossed over to the alternative induction regimen because of
      progressive disease after an initial partial response; one was crossed over
      because of toxicity. On crossover, four patients achieved complete remission, two
      on either regimen. Durations of unmaintained complete remission range from 6-46+
      months, with 8/13 still in their first complete remission. Only one patient has
      died, while in remission, from progressive Kaposi's sarcoma; one was lost to
      follow-up while in complete remission at 44 months; the others (85%) remain alive
      33-54 months from the initiation of chemotherapy. MOPP was significantly more
      toxic with respect to thrombocytopenia, duration of myelosuppression, and
      cumulation of toxicity. Because of its more acceptable toxicity, COP is
      recommended as initial therapy for patients with nodular, poorly differentiated,
      lymphocytic lymphoma. MOPP or another regimen of non-crossresistant combination
      chemotherapy would be more appropriate for primary treatment failures.

PMID- 1036468
TI  - Phase II evaluation of VP-16-213 (NSC-141540) and cytembena (NSC-104801) in
      patients with advanced breast cancer.

PMID- 1036469
TI  - [Drop in pulmonary surfactant in rats after loss of blood (author's transl)].

PMID- 1036470
TI  - Effects of an antiandrogen, cyproterone acetate, on the kidney of the three
      spined stickleback (Gasterosteus aculeatus L.).
AB  - The fine structure of the kidney is studied in the sexually mature male three
      spined stickleback after administration of an antiandrogen, cyproterone acetate.
      Under these conditions, the dedifferentiation of renal tubules is characterized
      by the same involutive processes as those induced by castration, with the
      difference that cyproterone acetate only begins to act after 14 days whereas
      after castration the first signs of involution are visible after 7 days. The
      ultrastructural modifications affect the nucleoli, the rough endoplasmic
      reticulum and the Golgi apparatus. They reflect an inhibition of the secretory
      process. The results obtained demonstrate that administration of cyproterone
      acetate to male sticklebacks has an inhibitory effect on renal target cells,
      apparently indistinguishable from the changes induced by lack of male sex
      hormone, and that this drug may be a valid substitute for castration in fish.

PMID- 1036471
TI  - [Drepanocytosis and navigation personnel].
AB  - In West and Central Africa one adult in 4 or 5 carries AS trait. This haemoglobin
      abnormality therefore underlines the question of aptitude of navigation personnel
      in national or international air-lines. Among these personnel one should separate
      commercial navigation personnel (CNP) and technical navigation personnel (TNP),
      if the aptitude in flight of CNP may perhaps be acquired without systematic
      previous submission to files of Civil Aeronautics Medical Advice, on the other
      hand a definite and irrefutable decision on the aptitude of TNP can only be
      envisaged after proving tests for placing the personnel carrying sickle cell
      trait in the context of airling work.

PMID- 1036472
TI  - [Clinical and therapeutic study of cholera in Dahomey. (133 clinical cases)].

PMID- 1036473
TI  - [Results of a survey of potential dengue vectors in the Neo-Caledonian
      archipelago].
AB  - The author gives the results of an entomological survey in neo-caledonian
      archipelago (New Caledonia and Loyalty Islands), november-december 1972.
      Concerning the distribution and the abundance of Aedes aegypti, the local dengue
      vector, this study shows the presence of this culicid not only in Noumea, but
      also all along the western developped coast of New Caledonia, and in Ouvea
      Island. This constitutes a great risk of outbreak extension from Noumea if a
      dengue virus is again imported there.

PMID- 1036474
TI  - [Surgey of tick-borne arboviruses in the Central African Republic (1973-1974).
      Isolation of Dugbe, CHF/Congo, Jos and Bhanja viruses].
AB  - As a complement of the study of the epidemiology of the arboviruses in Central
      Africa a survey of tick borne viruses has been done, in the Central African
      Republic, from December 1972 to June 1974; 15.103 ticks were collected, mainly
      from cattle at the slaughterhouses. They include: 10.085 Ambylomma variegatum,
      4.113 Boophilus, 542 Rhipicephalus and 363 Hyalomma. From 892 monospecific pools
      inoculated into baby mice, 98 isolates of virus were obtained. Among the 57
      isolates which have been fully identified (the identification of 41 other
      isolates is still in progress), 4 different serotypes of arbovirus have been
      found: Dugbe virus has been the most frequently found with 45 isolates from A.
      variegatum and I from B. decoloratus; this virus, previously isolated from human
      cases in Central African Republic in 1967 and 1970 has been isolated from a new
      human case in 1973. One isolate of CHF/Congo virus has been obtained from
      Hyalomma nitidum, but this virus has not yet been isolated from human beeings in
      C.A.R. The two other tick borne viruses isolated during this survey are Jos virus
      (9 isolates) and Bhanja virus (I isolate), all of them from A variegatum.

PMID- 1036475
TI  - [10 new clinical cases of mycoses caused by Entomophorales in Cameroon].
AB  - Authors describe ten new cases of Entomophthoromycosis in Cameroon. In four cases
      of subcutaneous phycomycosis, Basidiobolus meristoporus was isolated in one case.
      In six cases of rhino-entomophthoromycosis, we have obtained by culture two
      Basidiobolus meristoporus and one Entomophthora coronata. In Cameroon, rhino
      entomophthoromycosis may be caused by the two species Basidiobolus meristoporus
      and Entomophthora coronata.

PMID- 1036476
TI  - The operational implications of resistance of malaria vectors to insecticides in
      Iran.

PMID- 1036477
TI  - [Epidemiology of leishmaniasis in Algeria. 6. Survey of clinical cases of
      infantile visceral leishmaniasis from 1965 to 1974].
AB  - The authors present the results of an inquiry conducted in the principal
      hospitals of Algeria. The number of cases of visceral leishmaniasis recorded over
      the last ten years (1965 to 1974) totaled 497. The disease occurs essentially in
      children under 5 years of age (94%); it is mainly detected in central and eastern
      parts of the Tell region: principally in the Grande Kabylie, Algerois and
      Constantinois areas (humid and sub-humid bioclimatic stages). The results of the
      malaria eradication campaign in relation to the incidence of visceral
      Leishmaniasis is discussed.

PMID- 1036478
TI  - Species of gastro-intestinal nematodes of sheep from Iran.

PMID- 1036479
TI  - [The average degree of parasitosis, a criterion for evaluation of the
      geohelminthic contamination of a population, and for application of santiary
      measures].
AB  - The severity of ascaridiasis in a region depends first of all on the degree of
      pollution by ascaris ova of the environemtn and consquently on the per diem
      output of ascaris ova in the stools. Therefore, the importance of ascaridiasis as
      an endemic disease, depends of course upon the number of positive cases, their
      prevalence, but still more, it depends upon the intensity of the infection of the
      diseased population (global parasitic discharge). Practically, this concept of
      global parasitic discharge is expressed by the number of ascaris ova expelled per
      gram and per day by a sample of the considered population. The mean parasitic
      discharge is the quotient of the global parasitic discharge through the number of
      positive cases of the sample. An epidemiological survey and a mass chemotherapy
      test at La Reunion has showed us that the conept of global parasitic discharge is
      a more representative reliable and sensitive measuring method than prevalence, to
      evaluate the gravity of endemic ascaridiasis and its variations.

PMID- 1036480
TI  - Arthroscopy of the Knee.
AB  - Two hundred and twenty-one consecutive arthroscopic examinations of the knee are
      reviewed to establish diagnostic accuracy based on subsequent arthrotomy and the
      clinical course in the absence of arthrotomy. One hundred and nine knees showed
      an arthroscopic accuracy of 89.9 per cent at subsequent arthrotomy. Ninety-five
      patients who did not have an arthrotomy revealed 73.7 per cent clinical
      improvement between 9 months and 4 years after arthroscopy. Arthroscopy is a
      simple diagnostic procedure which, with experience, can be done safely and
      accuratly with minimal morbidity and, in this series, allowed 33.5 per cent of
      patients to avoid arthrotomy.

PMID- 1036481
TI  - A multi-centre general practitioner assessment of butriptyline hydrochloride
      ('Evadyne').
AB  - A multi-centre open study in general practice was carried out to assess the
      efficacy of and incidence of side-effects with the tricyclic antidepressant,
      butriptyline. Of a series of 153 patients with non-psychotic depression, with or
      without anxiety, 105 (69%) were judged as having a good or fair response to
      treatment with 75 mg to 150 mg butriptyline daily. Side-effects of an
      anticholinergic nature were seen in 13.7% of patients, but the incidence
      decreased to less than 4% in the 101 patients receiving treatment for over 7
      weeks.

PMID- 1036482
TI  - Circulating immune complexes in Graves' disease.
AB  - Circulating immune complexes in Graves' disease sera were detected by the 125I
      Clq deviation test. High titers of immune complexes were detected and correlated
      significantly with the microsomal antibody but not with the thyroglobulin
      antibody titer nor with serum thyroxine levels. Serum fractionation studies in a
      patient with high titer of immune complexes revealed these to be heterogeneous in
      size, sedimenting in 19S, intermediate and 7S regions. The data suggest a role
      for immune complexes in the pathogenesis of Graves' disease.

PMID- 1036483
TI  - Questions to the supply of young infants with fat and fatty acids. II. Fat
      content and fatty acid pattern in milk formulae for healthy infants in the first
      6 months of life.
AB  - The fat content and the fatty acid pattern were analyzed in 30 commercially
      prepared milk formulae for healthy infants in the fisrt 6 months of life. We
      found an average fat content of 3.4 g or 3.6 g/100 ml in "partly adapted" and
      "adapted" milk formulae, between 1.4 g and 3.3 g/100 ml in "not defined" milk
      formulae. We regard a fat content lower than 3.0 g/100 ml and more than 4.0 g/100
      ml as not advisable. In most milk formulae the ratio of saturated: unsaturated
      fatty acids is similar to the ratio in human milk fat. This ratio is obtained
      from a mixture of cow's milk fat with vegetable oils or by a mixture of various
      vegetable fats. The difference in the fatty acid pattern between the milk
      formulae and the fatty acid pattern in mature human milk are demonstrated and
      discussed. The tolerance of milk formulae for young infants is not influenced in
      an unfavorable manner by butyic acid. A high portion of lauric acid in mild
      formulae seems undesirable. The importance of the position of palmitic acid in
      the triglycerides of milk formulae for infants is discussed, and it is referred
      to the advantage of a mixture of cow's milk fat with vegetable fats. A linoleic
      acid content of 3 kcal% in the minimum and 7 kcal% in the maximum in milk
      formulae for infants is regarded as advisable.

PMID- 1036484
TI  - Changes in erythropoiesis and renal ultrastructure during exposure of mice to
      hypoxia.
AB  - During hypoxia, elevated ESF levels occur which are accompanied by increased
      erythropoietic activity resulting in progressive elevation of the haemoglobin and
      haematocrit concentration. An attempt has been made to correlate ultrastructural
      changes in the kidney with changes in serum ESF concentrations and the
      erythropoietic state of mice exposed to continuous hypoxia for 3 weeks. A series
      of changes in the epitheloid and proximal tubules cells occurred which may be
      related to the biogenesis of erythropoietin. However, no detectable ESF or renal
      erythropoietic factor could be extracted from the kidneys at the time of maximal
      ultrastructural changes. Although some ESF-inhibitory material was demonstrated,
      it could not be extracted into lipid solvents. It is suggested that the failure
      to consistently extract an erythropoietic factor from the kidneys of hypoxic mice
      may be related to the absence of renal storage at the onset of increased
      peripheral demand. Other levels and durations of hypoxia may help to elucidate
      the role of the kidneys in regulating serum ESF levels.

PMID- 1036485
TI  - Ox-spleen erythropoietic factor: chromatographic investigations and dosages.

PMID- 1036486
TI  - Biosynthesis of enniatin B.

PMID- 1036487
TI  - [Role of the autonomic nervous system in the differentiated response of
      pancreatic enzyme secretion].
AB  - In chronic studies on fistular dogs, the basal secretion of pancreas and
      secretion stimulated by the duodenal perfusion of acid (pH 1.5) solutions of
      albumen and its poly-peptide hydrolysate was studied. Perfusion of the
      hydrolysate stimulated the pancreatic release of enzyme more than albumen itself.
      Pentamin, atropin, and ergotal suppressed basal secretion and secretion
      stimulated by the duodenal perfusion with the above solutions.

PMID- 1036488
TI  - [The problem of venereal diseases in Mexico].

PMID- 1036489
TI  - Effect of localization of L-asparaginase as the concanavalin A conjugate on anti
      tumor activity.
AB  - A method potentially capable of enhancing the effectiveness of therapeutic
      enzymes such as L-asparaginase was investigated. The method was suggested by the
      following properties that have been observed for lectins injected into tissues:
      (1) six lectins with differing specificities were retained near the site of
      injection in the feet of mice 10 to 100 times longer than several non-lectin
      proteins. Prolonged retention of 125I-labelled concanavalin A was also observed
      in other normal and malignant mouse tissues. (2) The retention of 125I-labelled
      concanavalin A was not affected by prior immunization against concanavalin A. (3)
      Electrophoresis of tissue extracts on sodium dodecyl sulfate-poly-acrylamide gels
      followed by radioautography indicated that the 125I-labelled concanavalin A
      retained in the tissue remained as intact in form as prior to injection. Since
      the therapeutic efficacy of many enzymes may be enhanced by localization at the
      intended site of action, in principle it should be possible to enhance the
      effectiveness of therapeutic enzymes by combining the tissue-localizing
      properties of a lectin with therapeutic effectiveness of the enzyme. A conjugate
      of E. coli L-asparaginase and concanavalin A has been prepared by covalent cross
      linking with glutaraldehyde and has been shown to be retained in mouse tissue 90
      times longer than the free enzyme. However, it is completely ineffective in the
      treatment of the L-asparaginase-sensitive lymphosarcoma 6C3HED in C3H/HeJ mice.
      The ineffectiveness of the conjugated enzyme may be associated with the
      interiorization of the conjugate by the cells of the tumor.

PMID- 1036490
TI  - The immunospecificity of altered initial arrest patterns of circulating cancer
      cells in tumor-bearing mice.
AB  - The early arrest patterns of a methylcholanthrene-induced fibrosarcoma were
      determined after injection of 125IUdR-labelled cells into the systemic
      circulation of mice bearing transplanted lymphosarcomas, and of normal animals.
      Similar experiments were performed using radiolabelled lymphosarcoma cells and
      normal or fibrosarcoma-bearing mice. The results showed that shifts in normal
      distribution patterns previously observed in tumor-bearing animals injected with
      cells of the same type as that borne by the animal, were not detectable when
      cells of a different tumor type were injected. Peritoneal exudate cell migration
      inhibition assays showed little immunologic cross-reactivity between the two
      tumors and, together with the results of the distribution studies, indicated that
      alterations of early arrest patterns in mice sensitized to their tumor is an
      immunologically specific phenomenon.

PMID- 1036491
TI  - Infection of a nonspecific urethritis patient and his consort with a pathogenic
      species of nonspecific urethritis Corynebacteria, Corynebacterium genitalium, N.
      SP.
AB  - A patient with nonspecific urethritis (NSU) and his consort were examined for
      infection with NSU corynebacteria, mycoplasmas, and gonococci. No classic and T
      mycoplasmas or gonococci were cultured, but one species of NSU corynebacteria was
      isolated not only from the patient's urethral discharge during three episodes of
      NSU but also from his consort. It was not isolated after successful treatment of
      the patient with tetracycline and the use of condoms prevented reoccurrence of
      urethritis. This NSU corynebacterium was isolated previously from one
      epididymitis patient and two NSU patients but not from any of the normal male and
      female subjects examined. Therefore, this strain is considered to be one of the
      etiologic agents of NSU and female subjects are asymptomatic carriers. In
      consequence, it is suggested that NSU corynebacteria which are commensals and
      pathogens of the male and female urogenital tracts should be incorporated in a
      new species, of the Coryneform group, and that this strain should be the type
      species, Corynebacterium genitalium n. sp.

PMID- 1036492
TI  - The reliability and diagnostic validity of the physical and neurological
      examination for soft signs (PANESS).
AB  - Twenty-one children, mean age of 8 years, were each examined on separate
      occasions by two pediatric residents, blind to diagnosis, using the neurological
      examination (PANESS) included in the group of instruments recommended by the
      National Institute of Mental Health for psychotropic drug studies in children.
      Half the children were hyperactive/aggressive, one quarter were normal, and one
      quarter had histories or signs strongly presumptive of brain damage. Many of the
      signs, though reliable, did not occur in the majority of children. Examiners did
      achieve a high level of agreement about global neurological status. It was
      concluded that the neurological examination probably contains a substantial
      number of non-contributory items and should be regarded as experimental rather
      than definitive.

PMID- 1036493
TI  - Catechol-O-methyltransferase activity in psychotic children.
AB  - Catechol-O-Methyltransferase (COMT) activity was studied in three groups of
      institutionalized children: (1) a group of schizophrenic children; (2) a
      heterogeneous group of chronic psychotic children characterized by severe
      symptomatology and onset before 5 years of age; (3) a group of acting-out but
      nonpsychotic children. Erythrocyte COMT activity was found to be significantly
      lower among the schizophrenic subjects in contrast to the greater activity in
      both the other groups--the nonpsychotic and chronic psychotic children. The
      difference in COMT activity between psychotic groups appeared to be related to
      diagnosis and age of onset of disorder. Generality of findings is limited by the
      small sample size (N = 42) and by the difficulties inherent in the diagnosis of
      severe mental disorder in children. However, this preliminary study suggests that
      enzymatic activity may be associated with the development of schizophrenia in
      children.

PMID- 1036494
TI  - Autistic children exhibit undetectable hemagglutination-inhibition antibody
      titers despite previous rubella vaccination.
AB  - The etiology of autism is unknown, but autism has been associated with a number
      of diseases, including prenatal rubella. Rubella vaccine challenge was used in an
      attempt to retrospectively diagnose prenatal rubella in autistic children. This
      test was selected because unresponsiveness of antibody titer has been reported as
      helpful in retrospective diagnosing of prenatal rubella. Fifteen autistic
      children and 8 controls matched for age were challenged with rubella vaccine.
      Rubella vaccine challenge did not differentiate autistic children from the
      control subjects. However, 5 of 13 autistic children had undetectable titers
      despite previous vaccine; all control subjects had detectable titers. This
      finding of undetectable titers in autistic children suggests these children may
      have an altered immune response.

PMID- 1036495
TI  - Reactions to "employing electric shock with autistic children".

PMID- 1036496
TI  - Multiple factors in short-term behavioral control of protein intake in rats.
AB  - The availability and concentration of dietary protein was varied in an
      examination of the nature of the day-to-day intake of protein solutions by 60-day
      old male rats. It was found that the rats consumed a remarkably constant absolute
      amount of protein each day, adjusting overall caloric intake to maintain protein
      at a roughly constant proportion of total calories. Factors such as the time of
      access to a protein source or the extent of prior experience with a protein
      source were seen to influence the overall constancy of protein intake, whereas
      daily shifts in preference between two available concentrations of protein did
      not interfere with such short-term control. The mechanism for this behavioral
      control is likely to be different from mechanisms mediating the conditioned
      response to dietary protein, as in the response to dietary amino acid imbalance.

PMID- 1036497
TI  - Incidence and identification of phospholipase C-producing bacteria in fresh and
      spoiled homogenized milk.
AB  - Bacteria which produced phospholipase C were isolated from 13 of 34 fresh and 15
      of 35 spoiled samples of homogenized milk. No single off flavor was assigned
      consistently to samples with phospholipase producers, but 75% of them were
      bitter. Pseudomonads constituted 62% of the isolates. Other phospholipase C
      producing genera and their numbers were Acinetobacter, two; Alcaligenes, three;
      Bacillus, two; Citrobacter, one; Enterobacter, three; and Flavobacterium, two.
      Two unidentified yeasts also were isolated.

PMID- 1036498
TI  - The content of 90Sr in the bone tissue of the population of the Soviet Union.
      (1959-1971) (The basic laws of its accumulation and distribution).
AB  - On the basis of the results of long-term observations, general laws have been
      identified determining the dynamics of 90Sr concentration in the bone tissue of
      the population of the USSR in 1959-71, the peculiarities of 90Sr accumulation in
      different age groups and the connection and dependences between the intake and
      the contect of the isotope in human organism. It has been found that maximum 90Sr
      concentration occur in children born in the year when nuclear tests were carried
      out. The type of distribution of the frequency of occurrence of cases showing
      different levels of 90Sr content in uniform population groups was determined.
      Characteristic features of 90Sr distribution in different bones of the skeleton
      and its changes in the course of time were demonstrated.

PMID- 1036499
TI  - Intussusception in the older child- suspect lymphosarcoma.
AB  - Examination of the records of 378 children with intussusception at our
      institution revealed that 29 cases were caused by an identifiable intestinal
      lesion. A Meckel's diverticulum was the causative agent in 21 children, all of
      whom were under 2 yr of age. A previously undiagnosed ileal lymphosarcoma
      produced the intussusception in six other children, all between 6 1/2 and 9 yr of
      age. Our experience indicates that any child over 6 yr of age with the clinical
      findings of colicky abdominal pain, bloody stools, and a palpable mass plus the
      radiographic evidence of intussusception must be considered to have ileal
      lymphosarcoma until proven otherwise. Hydrostatic reduction of the
      intussusception must be accompanied by extensive small bowel reflux of barium in
      order to effectively rule out a small intestinal lesion. If this is not
      accomplished, surgery should be planned with the suspicion that a malignancy may
      be present. If this suspicion is confirmed by frozen section, the operation
      procedure should include wide surgical excision of the lesion along with the
      regional lymph nodes.

PMID- 1036500
TI  - Bioavailability assessment under quasi- and nonsteady-state conditions III:
      Application.
AB  - The applicability of bioavailability assessment at quasi- and nonsteady state is
      illustrated with data from a study comparing two formulations of amitriptyline
      hydrochloride in humans. Relative bioavailability as a function of the observed
      mean plasma concentrations may be expressed in closed form, provided the affected
      intervals begin and end in the log-linear region. Alternatively, numerical,
      graphical and/or electronic computational techniques may be used to stimulate the
      appropriate [Cp(i)]sim, the proximity of which to [Cp(i)]obs is a function of
      relative bioavailability and omega. If a model can be found to fit the data
      adequately, it would be sufficient that only one sampled interval end in the log
      linear phase.

PMID- 1036501
TI  - The electrophysiologic effects of tolamolol (UK-6558-01) on the passive membrane
      properties of mammalian cardiac Purkinje fibers.
AB  - Tolamolol (UK-6558-01) is a relatively cardioselective beta receptor antagonist
      which is effective clinically in the treatment of supraventricular and
      ventricular arrhythmias. Animal studies suggest tolamolol may have significant
      antifibrillatory properties. The effect of tolamolol on the passive membrane
      properties of sheep cardiac Purkinje fibers was studied using multiple
      microelectrode techniques. In sodium-deficient Tyrode's solution, we measured the
      resting transmembrane voltage (Vr) at differing external potassium concentrations
      (K+]0, investigated current-voltage relationships and per formed cable analysis.
      Tolamolol was found to hyperpolarize the membrane in the presence of a large
      driving force [i.e., when (Vr - VK) was significantly greater than zero, where VK
      is the potassium equilibrium voltage ]; to hyperpolarize fibers with a Vr
      decreased due to stretch at [K+]0 = 4.0 mM; to increase membrane chord and slope
      potassium conductance; to decrease the membrane length constant; and to decrease
      the membrane time constant. In normal sodium Tyrode's solution, tolamolol could
      suppress automaticity. These results suggest that tolamolol increases membrane
      potassium conductance within the range of the pacemaker potential. This action
      can account, in part, for its ability to suppress automaticity and for its
      ability to prevent reentrant arrhythmias. In normal sodium Tyrode's solution,
      tolamolol suppressed oscillatory and sustained rhythmic activity occurring at a
      low transmembrane voltage which may be related to its alleged antifibrillatory
      effects.

PMID- 1036502
TI  - Correlation between analgesia and the decrease of acetylcholine turnover rate in
      cortex and hippocampus elicited by morphine, meperidine, viminol R2 and
      azidomorphine.
AB  - In rats, an ED50 for analgesia of morphine, meperidine, viminol R2 or
      azidomorphine decreases the turnover rate of acetylcholine (TRACh) in cortex and
      hippocampus. These four analgetics fail to change to TRACh in striatum when given
      in a dose range from ED30 for analgesia up to a cataleptic dose. Viminol S2, a
      nonanalgesic stereoisomer of vimonol R2, fails to decrease the TRACh in cortex
      and hippocampus. Naltrexone, an opiate antagonist, also fails to change the
      cortical and hippocampal TRACh but it antagonizes the decrease in cortical and
      hippocampal TRACh elicited by the four analgetics. Since the ED50 of these four
      analgetics fails to change the TRACh in striatum which contains a high density of
      opiate receptors and intrinsic cholinergic neurons, but decreases the TRACh in
      hippocampus and cortex which contain a low density of opiate receptors, it can be
      inferred that opiate receptors are not exclusively involved in the regulation of
      TRACh. However, the results suggest that certain cholinergic pathways participate
      in the mediation of analgesia.

PMID- 1036503
TI  - In-vitro fertilization of ova from senescent mice and hamsters.

PMID- 1036504
TI  - Effects of pituitary graft and 2-bromo-alpha-ergocryptine on mammary DNA
      synthesis in mice in relation to mammary tumorigenesis.
AB  - 3H-thymidine incorporation into mammary DNA as an index of mammary DNA synthesis
      in C3H/He virgin females was significantly higher at proestrus than at estrus and
      diestrus. The rise in incorporation at proestrus was completely blocked by the
      administration of 2-bromo-alpha-ergocryptine (Bromocriptin) 1 day before
      proestrus. The incorporation was maintained at a higher level than that at
      proestrus by pituitary grafts. The results supported the view that mammary DNA
      synthesis, which is stimulated by prolactin, is an important factor for mammary
      tumorigenesis.

PMID- 1036505
TI  - Interaction of estrogen and prolactin in spontaneous mammary tumorigenesis of the
      mouse.
AB  - Daily treatment for 12 months of young nulliparous C3H mice with 0.1 mg 2-bromo
      alpha-ergocryptine (CB-154), an effective suppressor of prolactin secretion,
      significantly reduced and in some instances virtually eliminated the incidence of
      spontaneous mammary tumors. The CB-154-treated mice had normal body weight gains
      and normal estrous cycles. Ovariectomy of young nulliparous C3H mice also reduced
      mammary tumor incicence, but appeared to be slightly less effective than
      treatment with the ergot. Chronic administration of 17beta-estradiol for 12-19
      months (via drinking water) to young nulliparous intact or ovariectomized
      hysterectomized C3H mice significantly increased mammary tumor incidence.
      Concurrent administration of 0.1 mg CB-154 to the estrogen-treated mice
      significantly reduced the incidence of mammary tumors when compared with mice
      treated with the steroid alone. Chronic sc administration (0.1 mg/mouse, twice
      weekly for 20 months) of Enovid to young, nulliparous, intact C3H mice
      significantly increased mammary tumor incidence, whereas concurrent
      administration of 0.1 mg CB-154 to the Enovid-treated mice significantly reduced
      the incidence of these tumors. Thus significant inhibition of spontaneous or
      estrogen- or Enovid-induced mammary tumorigenesis by concurrent drug-induced
      prolactin suppression has been demonstrated in these studies.

PMID- 1036506
TI  - Fluorouracil as an adjuvant to colorectal cancer surgery.

PMID- 1036507
TI  - Preventing bubbles in intravenous tubing.

PMID- 1036509
TI  - Breast prostheses.

PMID- 1036508
TI  - Polyps of the colon.

PMID- 1036510
TI  - Does juvenile temporal arteritis exist.

PMID- 1036511
TI  - Quinacrine ochronosis.

PMID- 1036512
TI  - Bronchial artery embolization for massive hemoptysis.
AB  - Improved angiographic techniques have proved that therapeutic embolization is
      effective in controlling massive hemorrhage in selected sites of the
      gastrointestinal tract and central nervous system. We have controlled massive
      hemoptysis in five cases with use of our improved techniques and bronchial artery
      embolization. Because mortality due to massive hemoptysis in both benign and
      malignant disease is high, therapeutic bronchial artery embolization is the
      preferable approach in some cases.

PMID- 1036513
TI  - Y-chromosomal genes in a phenotypic male with a 46XX karyotype.
AB  - A number of patients with a male phenotype and a female (46XX) karyotype have
      been described. Although there is little or no evidence for the presence of a Y
      chromosome in their cells, these individuals resemble patients with Klinefelter
      syndrome (47XXY). Using a new serological assay for the presence of H-Y antigen,
      a cell surface component associated with the Y chromosome, we have demonstrated
      the presence of Y-chromosomal genes in a 46-year-old man with an XX karyotype. In
      addition, using standard cytological technique, we have located a minor
      population of XXY cells as well as cells bearing and abnormal chromosome 17 among
      the blood leukocytes of this individual.

PMID- 1036514
TI  - Undernutrition. Cultural diagnosis and treatment of "runche".

PMID- 1036515
TI  - Job specifications for the President of a County Medical Society or how the
      Establishment remains established.

PMID- 1036516
TI  - Severe transient pancytopenia associated with procainamide ingestion.
AB  - A 73-year-old woman was found to have clinically significant pancytopenia in
      association with procainamide hydrochloride ingestion. The syndrome, resembling
      systemic lupus erythematosus, which has been reported to develop in patients
      treated with this agent, is characterized by mild to moderate anemia and mild to
      moderate granulocytopenia. Severe granulocytopenia in patients taking
      procainamide and unrelated to a lupus syndrome has not previously been reported
      in association with significant thrombocytopenia. The clinical severity of this
      patient's presentation, suggesting an aleukemic leukemia, and its complete
      remission after cessation of procainamide administration occasional this report.

PMID- 1036517
TI  - Mycoplasmemia in adult male patients.
AB  - Mycoplasma hominis mycoplasmemia was associated with obstruction, manipulation,
      or surgery of the genitourinary tract in five adult men. A four-fold increase in
      specific antibody titer against M hominis was demonstrated in serial convalescent
      serum obtained from one patient. Two patients became afebrile after treatment
      with tetracycline; a third recovered without therapy for a Mycoplasm infection.
      The two remaining patients died of thier underlying diseases.

PMID- 1036518
TI  - Hemiparesis in cervical spondylosis.
AB  - Two patients with hemiparesis were thought to have intracranial lesions. Cervical
      spondylosis was discovered, and the condition of both patients improved after
      laminectomy. Although it has been rarely emphasized in the past, cervical
      spondylosis should be considered in the differential diagnosis of hemiparesis.

PMID- 1036519
TI  - Lead poisoning from cocktail glasses. Observations on two patients.

PMID- 1036520
TI  - Sarcoidosis presenting as multiple pulmonary nodules.

PMID- 1036521
TI  - Popliteal vein aneurysm with recurrent pulmonary thromboemboli.

PMID- 1036522
TI  - Transient paralysis of the phrenic nerve associated with head injury.

PMID- 1036523
TI  - Nutrition instruction in Medical Schools--1976.

PMID- 1036524
TI  - Diagnosis by deduction: reprise.

PMID- 1036525
TI  - "Runche": cultural problems of deprivation.

PMID- 1036526
TI  - Management of cancer.

PMID- 1036527
TI  - Hypertension screening.

PMID- 1036528
TI  - Echocardiography and tumor invasion of the heart.

PMID- 1036529
TI  - Cancer and diet.

PMID- 1036530
TI  - Halothane arrhythmia.

PMID- 1036531
TI  - Carotenemia vs jaundice.

PMID- 1036532
TI  - Expectoration of bronchogenic tumor tissue.

PMID- 1036533
TI  - Monitoring temperature during anesthesia.

PMID- 1036534
TI  - Egregious errors in the management of hypertension.

PMID- 1036535
TI  - Intrinsic asthma in adults. Association with gastroesophageal reflux.
AB  - Of 28 patients with severe asthma routinely examined with upper gastrointestinal
      (UGI) x-ray films, 18 (64%) were found to have hiatus hernia and 13 (46%) were
      found to have demonstrable gastroesophageal reflux. These prevalences differed
      significantly (P less than .001) from those seen in a control population (19% and
      5%, respectively). These data suggest that aspiration of gastric acid is a
      frequent incitant to severe asthma and that it should be routinely sought in the
      treatment-resistant asthmatic patient. Intensive medical regimens directed
      against reflux and acidity may bring notable improvement in asthma symptoms.
      Surgical restoration of effective lower esophageal spincter function has proved
      to be curative in other reported studies.

PMID- 1036536
TI  - Multiple epiphyseal dysplasia. A family case report.
AB  - Six cases of multiple epiphyseal dysplasia were found in a 30-member kindred. The
      kindred showed an increased incidence of other joint abnormalities. A dominant
      pattern of inheritance was not confirmed.

PMID- 1036537
TI  - Syphilis surveillance. Failure to screen in a university hospital.
AB  - Of 5,954 adult inpatients consecutively discharged from a university hospital
      during a three-month period, only 8.4% had serologic tests for syphilis performed
      during hospitalization. The testing rate was 20.1% on patients admitted to a
      medical teaching service and 1.4% on a surgical teaching service. In patients
      tested, a positive rapid plasma reagin test result was obtained in 6.2% and the
      diagnosis was confirmed by further testing, but effective therapy was not always
      given. On 9 of 30 patient records listed syphilis as a diagnosis on discharge. We
      conclude that serologic testing for syphilis is routinely omitted in the
      evaluation of hospitalized patients; even when tests are positive, the results
      are often ignored.

PMID- 1036538
TI  - Patient complaints against physicians in the Richmond area during 1973.

PMID- 1036539
TI  - Adverse reactions in treatment with lithium carbonate and haloperidol.
AB  - Hospital records of 425 patients who had been treated simultaneously with lithium
      carbonate and haloperidol were examined. Adverse reactions in these patients were
      the same as in patients given lithium alone or haloperidol alone. None of the
      patients developed a syndrome resembling that described by others in patients
      treated with a lithium and haloperidol combination.

PMID- 1036540
TI  - Destructive bone disease in early syphilis.
AB  - Although destructive bone disease is a well-known complication of tertiary
      syphilis, osteitis or osteomyelitis are not commonly recognized as complications
      of early (primary or secondary) syphillis. A patient with secondary syphilis
      characterized by generalized lymphadenopathy, perianal condyloma lata, and
      positive rapid plasma reagin (RPR) and fluorescent treponemal antibody-absorption
      (FTA-ABS) tests also complained of headache, right should pain, and right
      anterior chest pain and swelling. Roentgenograms showed mottled osteolytic
      lesions consistent with previously described luetic bone disease. Biopsy
      confirmed the diagnosis of syphilitic osteomyelitis, and treatment with
      penicillin resulted in prompt resolution of symptoms.

PMID- 1036541
TI  - Nonsurgical closure of large arteriovenous fistulas.
AB  - We report a nonsurgical closure of large postnephrectomy arteriovenous fistulas
      in two patients. To out knowledge, this method has not previously been attempted
      because of the large size of the communication and the risk of pulmonary
      embolization. However, the development of new embolization techniques makes a
      nonsurgical approach feasible and safe.

PMID- 1036542
TI  - Colonoscopy. Inefficacy for early carcinoma detection in patients with ulcerative
      colitis.

PMID- 1036543
TI  - Metronidazole and hepatic abscess. A false-positive response.

PMID- 1036544
TI  - Multiple squamous papillomas of the esophagus diagnosed by endoscopy.

PMID- 1036545
TI  - Digital gangrene.

PMID- 1036547
TI  - Who or what developed.

PMID- 1036546
TI  - Another form of latrogenic hypokalemia.

PMID- 1036548
TI  - The patient with acute diarrhea. An algorithm for diagnosis.

PMID- 1036549
TI  - Joint effusions in sickle cell-beta-thalassemia disease.

PMID- 1036550
TI  - The plutonium controversy.

PMID- 1036551
TI  - Asthma, ephedrine, and Olympic eligibility.

PMID- 1036552
TI  - Serum cholesterol.

PMID- 1036553
TI  - Anesthesia for elective termination of pregnancy.

PMID- 1036554
TI  - Individualization of phenytoin therapy.

PMID- 1036555
TI  - Arteriovenous fistula after femoral vein catheterization.

PMID- 1036556
TI  - Blood cultures drawn through catheters.

PMID- 1036557
TI  - Medical education in the United States 1975-1976.

PMID- 1036558
TI  - Recent events of special interest to medical education.

PMID- 1036559
TI  - Health Professions Educational Assistance Act of 1976.

PMID- 1036560
TI  - "Primary care" and graduate medical education.

PMID- 1036561
TI  - Education and medical licensure.

PMID- 1036563
TI  - Mandatory continuing medical education.

PMID- 1036562
TI  - Faculty responsibility for the competence of new physicians.

PMID- 1036565
TI  - Incidence of galactorrhea.

PMID- 1036564
TI  - Thyroid supplements and breast cancer.

PMID- 1036566
TI  - Successful protection of humans exposed to rabies infection. Postexposure
      treatment with the new human diploid cell rabies vaccine and antirabies serum.
AB  - Forty-five persons severely bitten by rabid dogs and wolves in Iran were treated
      after exposure with a new rabies vaccine produced in cultures of human diploid
      cells. All except one also received one injection of rabies immune serum. This
      treatment, in contrast to past experience with other vaccines, resulted in
      protection of all individuals against rabies. Thus, almost a century after the
      postexposure treatment of humans was initiated, an effective tool for protecting
      man against rabies has finally been developed.

PMID- 1036567
TI  - Identifying patients at risk for thromboembolism. Use of 125I-labeled fibrinogen
      in patients with acute myocardial infarction.
AB  - Fibrinogen labeled with iodine 125 was used to detect deep vein thrombosis (DVT)
      in 35 patients during their course and convalescence from acute myocardial
      infarction. Clinical status was assessed and scored with the use of a modified
      coronary prognostic index. According to the prognostic scores, patients were
      allocated to one of two groups. Of 27 patients in good clinical condition, DVT
      developed in only one patient, whereas thromboembolic complications occurred in
      seven of eight patients who were severely ill--a highly significant difference.
      Prophylactic anticoagulation is advisable in patients at risk.

PMID- 1036568
TI  - Unexpected cardiac arrest during anesthesia and surgery. An environmental study.
AB  - Medical and legal records of 41 cases of cardiac arrest that occurred during
      surgery were supplied by a professional liability insurance company and a review
      was undertaken in an attempt to identify recurring or common factors. The
      majority of patients in this study were healthy and required relatively routine
      elective surgical procedures. Only three of the patients survived the cardiac
      arrest and returned to normal activities. The remaining patients either died in
      the hospital or had a major central nervous system deficit. Hypoxia from
      hypoventilation and low levels of inspired oxygen appeared to be the chief cause
      of cardiac arrest in this study. Because of the unknown frequency of cardiac
      arrest during surgery, we recommend the establishment of a national registry of
      cardiac arrest cases that occur in surgical patients, in order to monitor
      incidence, causes, and outcome. Only in this way will it be possible to lessen
      the frequency of this disastrous event.

PMID- 1036569
TI  - Patients' response to tubal division.
AB  - Of the 187 women who underwent laparoscopic tubal division at the Massachusetts
      General Hospital between September 1969 and June 1973, one hundred thirty-nine
      were interviewed in a follow-up study. The mean age was 33.9 years; the mean
      gravidity was 5.0 and mean parity 3.8. Most women were married, with religious
      affiliations reflecting those of the general hospital population, and most
      underwent tubal division because they felt they had had enough children. The
      majority (85.6%) were satisfied with their decision and reported similar or
      improved mental and physical health and sexual activity. Almost all (93.5%) said
      that they would make the same choice again, and more than half (54.7%) would have
      liked to have had this operation earlier. Those ambivalent or regretful about
      their decision could not be readily identified by any preoperative
      characteristics such as age, parity, and marital status.

PMID- 1036570
TI  - Critical elements in the diagnosis of alcoholism. A national survey of
      physicians.

PMID- 1036571
TI  - Reversible renal failure and myositis caused by phenytoin hypersensitivity.
AB  - A 38-year old woman receiving phenytoin (diphenylhydantoin) noticed maculopapular
      erythema as the first manifestation of a syndrome that included acute renal
      failure and myositis in addition to fever, lymphadenopathy, exfoliative
      dermatitis, and hepatitis. Prednisolone sodium phosphate therapy resulted in
      resolution of this hypersensitivity reaction, and she recovered from renal
      insufficiency. The occurrence of renal failure and myositis in the spectrum of
      phenytoin hypersensitivity reactions is discussed, and the importance of a
      morbilliform rash in a patient receiving phenytoin is emphasized.

PMID- 1036572
TI  - Hyperkalemia with cardiac arrhythmia. Induction by salt substitutes,
      spironolactone, and azotemia.
AB  - In two patients, severe hyperkalemia and serious cardiac arrhythmia developed
      after excessive use of potassium-containing salt substitutes. Both had impaired
      ability to handle and excrete additional potassium load due to chronic congestive
      heart failure, azotemia, and administration of spironolactone. Prompt recognition
      of the arrhythmia and immediate restoration of the cardiac rate and rhythm by
      pacemaker support followed by intensive regimen to lower the serum potassium
      prevented a potentially fatal outcome. These cases emphasize the potential danger
      of salt substitutes when used by patients who are predisposed to retain
      potassium.

PMID- 1036573
TI  - Massive hemolysis caused by acetaminophen. Positive determination by direct
      Coombs test.

PMID- 1036574
TI  - Metastatic melanoma in the breast masquerading as fibroadenoma.

PMID- 1036575
TI  - Postoperative choledochoscopy via the T-tube tract.

PMID- 1036576
TI  - Transient cerebral ischemia and mitral-valve prolapse.

PMID- 1036577
TI  - "Toot-toot" and health to boot.

PMID- 1036578
TI  - The autonomous heart in diabetic autonomic neuropathy.

PMID- 1036580
TI  - The physician's estate. Part III.

PMID- 1036579
TI  - Pneumoperitoneum and right upper quadrant gas in a diabetic man.

PMID- 1036581
TI  - Hyperthermia and cellular immunity.

PMID- 1036582
TI  - Science and clinical medicine.

PMID- 1036583
TI  - Scuba diving.

PMID- 1036584
TI  - Meat-wrappers' asthma.

PMID- 1036585
TI  - Interpretation of article disputed.

PMID- 1036586
TI  - Oral contraceptives after intestinal bypass operations.

PMID- 1036587
TI  - Human umbilical cord. A new source for vascular prosthesis.
AB  - Reconstructions were performed to the popliteal, tibial, and peroneal arteries
      employing a modified umbilical cord vein prosthesis. The latter was obtained from
      human cords and was made available as an onshelf graft for surgery following
      glutaraldehyde tanning. The early patency and limb salvage rates are equivalent
      to those obtained with autogenous saphenous veins. Additional benefits include
      significant decreased operative time and morbidity. It is also probable that this
      new graft may be resistant to biodegradation and therefore may obviate many of
      the causes for late failure that occur with the use of living biologic tissues or
      collagen tubes. Long-term follow-up and study are essential to validate the
      results obtained thus far and  to assess the potential of this new graft in a
      variety of vascular reconstructions.

PMID- 1036588
TI  - How to deal with poor medical care.

PMID- 1036589
TI  - Shoulder enlargement as the presenting sign in syringomyelia. Report of two cases
      and review of the literature.
AB  - Two adult patients had painful enlargement of the shoulder and complete
      destruction of the humeral head. Angiograms of the shoulder showed highly
      vascular lesions in both patients. Both patients had syringomyelia, for which the
      swollen shoulder was the first manifestation.

PMID- 1036590
TI  - Phrenic nerve injury from subclavian vein catheterization. Diagnosis by
      electromyography.

PMID- 1036591
TI  - Occult rupture of the spleen: a dilemma in diagnosis.

PMID- 1036592
TI  - Retroperitoneal fibrosis and avascular necorsis of the femoral head.

PMID- 1036594
TI  - Evaluation of a new aerosolized steroid for asthma therapy: beclomethasone
      dipropionate (Vanceril inhaler).
AB  - Beclomethasone dipropionate, an esterified derivative of betamethasone, can be
      given in small doses in aerosol form to patients with severe asthma whose
      symptoms cannot be controlled with nonsteroidal agents (bronchodilators and
      cromolyn). Many asthmatic patients who previously required systemic steroids can
      be transferred to this safer anti-inflammatory agent. In usual doses,
      beclomethasone produces few, if any, systemic side effects. The only susbstantial
      reaction is Candida infections of the oropharynx and larynx.

PMID- 1036595
TI  - X-ray diffraction studies of lecithin bilayers.

PMID- 1036596
TI  - NDV-O agglutinins and heteroagglutinins in sera of blood donors.
AB  - In sera of healthy blood donors advancing age was accompanied by a decrease in
      the levels of agglutinins against human group O erythrocytes modified by
      Newcastle disease virus (NDV-O agglutinins) and of heteroagglutinins against
      sheep, guinea-pig and rabbit erythrocytes. Significant correlations of titres
      existed between the different heteroagglutinins, but not between these and the
      NDV-O agglutinins. The origins and interrelations of the natural agglutinins are
      discussed.

PMID- 1036597
TI  - [Oerations on peripheral nerves, plexus and nerve roots, including subarachnoid
      block with phenol in chronic pain (author's transl)].
AB  - Peripheral surgery was performed in 112 patients. Neurolysis or resection of
      neurons gave rather poor results in pain after nerve injury and stump pain.
      Rhizotomy is considered to be more effective in those cases. Rhizotomy is also
      successful in radicular, especially coccygeal, pain syndromes. Subarachnoid
      blocks with Phenol gave similar promising results. Causalgia responds well in a
      high percentage of cases to sympathectomy; cases of postherpetic neuralgia
      phantom pain and tabetic crises generally do not respond to peripheral surgery.

PMID- 1036598
TI  - [Follow-up study of the patients with Hansen's disease in Kyoto Prefecture
      (author's transl)].

PMID- 1036599
TI  - [A case report on leproma in the tongue (author's transl)].

PMID- 1036600
TI  - [On the several problems of leprosy out-patient treatment in Okinawa (author's
      transl)].

PMID- 1036601
TI  - [Cell-biological study on the acid-fast organisms isolated and cultivated from
      leprosy patients. I. Isolation frequency and biological properties of the
      organisms (author's transl)].

PMID- 1036602
TI  - Changes in cholesterol synthesis and excretion when cholesterol intake is
      increased.
AB  - The metabolic responses to increased amounts of dietary cholesterol include, in
      man, a reduction in the synthesis and an increase in the re-excretion of
      cholesterol. The effectiveness of these compensating mechanisms in preventing
      increases in the plasma cholesterol concentration was studied in nine subjects.
      Cholesterol absorption, the excretion of bile acids, the excretion of endogenous
      neutral steroids, and the cholesterol balance (synthesis) were measured twice
      during intakes of cholesterol of about 250 and 750 mg/day. The serum of the
      compensating mechanisms (reduction in synthesis and increase in excretion of
      cholesterol) almost equalled the increase in absorbed cholesterol when the intake
      was raised by 500 mg (mean change in compensation, 226 mg/day; mean changes in
      absorption, 230 mg/day). In three subjects in whom re-excretion of cholesterol
      was predominant and compensated for absorbed cholesterol, the plasma cholesterol
      levels rose substantially. In five others, in whom the predominant change was
      reduction in cholesterol synthesis, the rise in plasma cholesterol levels was not
      significant. At moderate intakes of cholesterol both compensating mechanisms
      prevented retention of dietary cholesterol in the body, though a rise in the
      plasma cholesterol level was prevented only when cholesterol synthesis was
      suppressed.

PMID- 1036603
TI  - Retrolental fibroplasia and sudden infant death syndrome.

PMID- 1036604
TI  - [Clinical experiences with iodoxamic acid in the cholecystography-cholangiography
      (author's transl)].
AB  - Intravenous contrast media must have an optimum biliary excretion and a small
      urinary excretion, also a good tolerability. These demands are not dependent on
      the proportion of iodine, but of the proportion of the transport medium. By
      searching for a good transport medium iodoxamic acid has been found. In
      experiments this acid was compared with other intravenous contrast media. A
      better tolerability and better diagnostical effectivity had been proved. At the
      clinical examination of 86 cases we could point out a very good to good
      tolerability and a good diagnostical effect. Our experiences conform to other
      authors all of the world. In the Federal Republic of Germany this contrast medium
      is called Endomirabil and exists in ampoules of 20 cc and 30 cc contents and in
      bottles of 100 cc contents.

PMID- 1036606
TI  - Soy-based formulas for infants.

PMID- 1036605
TI  - Drugs for athlete's foot and tinea cruris.

PMID- 1036607
TI  - [Retrolental fibroplasia (RLF)].

PMID- 1036608
TI  - Emergency, Inc.

PMID- 1036609
TI  - Growth and synthesis of rubratoxin by Penicillium rubrum in a chemically defined
      medium fortified with organic acids and intermediates of the tricarboxylic acid
      cycle.
AB  - A sterile glucose-mineral salts broth was fortified with equimolar concentrations
      (10--3 M) of various organic acids and intermediates in the tricarboxylic acid
      cycle. Appropriate media were neutralized with 2 N NaOH, inoculated with spore
      suspensions or mycelial pellets of Penicillium rubrum and incubated quiescently
      for 14 days or with shaking for 5 days. Rubratoxins were recovered from culture
      filtrates by ether extraction and resolved by thin-layer chromatography. Toxin
      formation in quiescent cultures was enhanced by malonate but was not markedly
      affected by ethyl malonate, shikimate, and acetate or by isocitrate or
      oxaloacetate added in the presence of malonate. Citrate, cis-aconitate, alpha
      ketoglutarate, succinate, fumarate, and malonate when present in the medium alone
      or in conjunction with malonate caused a 15 to 50% reduction in rubratoxin
      formation. Acetyl-CoA (10--5 M/flask) caused an 80% increase in toxin yield.
      Rubratoxin formation in shake cultures was not affected by succinate and
      malonate. All other combinations of intermediates and malonate caused a 10 to 50%
      reduction in toxin formation. At 10--3 M, citrate enhanced rubratoxin B formation
      and stimulated rubratoxin A production by as much as 100%. Above 10--3 M, citrate
      inhibited toxin production. Incorporation of [2-14C]acetate into rubratoxin was
      enhanced by malonate, fumarate, and malonate. A combination of pyruvate and
      malonate produced a 40% increase in [2-14C]acetate incorporation into rubratoxin.
      The highest reduction of labeled acetate incorporation (36%) was caused by
      succinate or alpha-ketoglutarate combined with malonate.

PMID- 1036610
TI  - [Detection of mineral oil and paraffin in foods].
AB  - The author describes a thin-layer chromatographic method for the detection of
      small amounts of mineral oil and paraffin in foods. Fatty acids, glycerides, fat
      soluble vitamins, sterols, and unsaturated hydrocarbons remain at the starting
      point. This method permits to detect as little as 0.2 mug of mineral oil or 20
      mug of mineral oil/kg of food in low-fat products. 0.01% of mineral oil-like
      contaminants may be detected in fats.

PMID- 1036611
TI  - [Lead and cadmium content of baby food and their nutritional hygienic
      toxicological significance].
AB  - Little is known of the amounts of lead and cadmium which the infantile organism
      takes up from the total diet. The author's analyses of more than 150 jars or
      packs of ready-to-use baby food produced in the German Democratic Republic (trade
      mark: Fur's Kind) revealed lead contents of less than 100 mug/kg and cadmium
      contents of less than 10 mug/kg. Only spinach showed higher lead values. In liver
      -containing ready-to-use foods the cadmium contents were higher than 10 mug/kg
      (25-50 mug/kg). Like liquid milk, powdered milk-base foods contained no cadmium.
      From these values it was calculated that the daily lead and cadmium intake of an
      infant during his first year of life amounts to 42-47 mug of lead and to 6,4-11,5
      mug of cadmium, respectively. A conversion to mg/kg of body weight shows that, in
      both cases, the load on an infant equals that on an adult or is even greater.
      Literature data lead intake are in good agreement with these results.
      Corresponding studies for cadmium are not known.

PMID- 1036612
TI  - [Neuroendocrine aspects of Parkinson's disease. Therapeutic/effect of a prolactin
      inhibitor].
AB  - On the basis of a reassessment of the aetiopathogenetic problem and the
      neuroendocrine implications, the therapeutic effectiveness of a prolactin
      inhibitor, 2-alpha-Br-ergocryptine (CB 154), in Parkinson's disease is assessed.
      Five patients were treated for a total of two weeks using doses between 10 and 15
      mg/die. CB 154 was found to act as a dopaminergic receptor agonist at nigro
      striatal level, considerably improving tremor and rigidity and to a lesser extent
      bradykinesia and total disability.

PMID- 1036613
TI  - Treatment of fibrocystic disease of the breast with a prolactin inhibitor: 2-Br
      alpha-ergocryptine (CB-154).
AB  - In order to evaluate the importance of prolactin in the pathogenesis and clinical
      evolution of fibrocystic disease of the breast, serum prolactin levels were
      determined in 7 patients affected by this condition before and during treatment
      with a prolactin inhibitor, 2-Br-alpha-ergocryptine (CB-154). Serum prolactin
      levels were found to be low or normal before treatment. During treatment with CB
      154 there was an improvement in all patients but 2. The results of the study do
      not allow any conclusion on the possible relation between serum prolactin levels
      and fibrocystic disease of the breast but they indicate that CB-154 may be useful
      for treating patients with this disorder.

PMID- 1036614
TI  - [Fluoride content of food in Hungary. I. Fluoride content of food and beverages].

PMID- 1036615
TI  - [On the radiotherapy of the carcinoma of the tonsils (author's transl)].
AB  - In the period 1932 to 1975 469 patients were admitted with a malignoma of the
      tonsils. 74,9% were stage T3. Nearly 50% showed up with involvement of fixated
      and suspicious lymphnodes. The relation men to women was 80:20. The highest
      incidence was found in the age group 61-70 a. The patients were treated using
      Radium: interstitial implants and external radiation, later Cobalt sources and
      the Betatron. The over-all 5 year survival rate is 21.6% for carcinomas and 32%
      for sarcomas. In the case histories there are predominantly late ones because
      difficulties in swallowing are neglected for a long time. The prognosis for cases
      stage T3 is rather bad. Considering the literature our material is the greatest
      out of a single department.

PMID- 1036616
TI  - [Five years treatment of advanced solid malignomas with a combination of four
      cytostatic drugs (author's transl)].
AB  - 132 patients with advanced solid malignomas were treated with a combination of
      four cytostatic drugs (vinblastine, amethopterine, 5-fluorouracil and
      cyclophosphamid) given on one day. This was repeated once every 2-3 weeks. In
      every case the diagnosis was made histologically and the tumour was staged
      according to the TNM-system. The treatment of breast and ovarian cancer brought
      the best results, improved by a synchronisation therapy. Good results were
      achieved also in the treatment of special kind of sarcomas and of carcinoma of
      the urine bladder. The general condition of patients with colon carcinoma could
      be improved in about 30%. Only one patient died by drug-induced pancytopenia,
      otherwise severe side-effects were not noted. Before beginning the therapy the
      cell-mediated immunity of 31 patients was tested by skin-tests with tuberkulin
      purified protein derivative (PPD) and dinitrochlorbenzole (DNCB). Before and
      during cytostatic therapy PPD reactions were proven by 23 patients. In accordance
      to other authors we found that cell-mediated immunity is decreased in the
      advanced stage of malignoma. Further we noted that delayed hypersensitivity and
      the number of lymphocytes and monocytes in peripherel blood are important to
      prognosis and course in patients with cancer.

PMID- 1036617
TI  - Pregnancy of the wife of a complete paraplegic by homologeous insemination after
      an intrathecal injection of neostigmine.
AB  - A case of successful pregnancy following artificial insemination following
      intrathecal neostigmine injection in the wife of a complete traumatic paraplegic
      (T7-T8 to T11-T12) is described.

PMID- 1036618
TI  - [Relationship of the surfactant level to the course of experimental pulmonary
      tuberculosis].

PMID- 1036619
TI  - Venereal disease and the homosexual.

PMID- 1036620
TI  - The problems of the venereal diseases in general practice.

PMID- 1036621
TI  - [Clinical evaluation of a new contrast medium for cholegraphy].

PMID- 1036622
TI  - The increased release of 3H-5-hydroxytryptamine by d-para-methoxyamphetamine and
      d-amphetamine in vivo.

PMID- 1036623
TI  - [The bile metabolites and extrahepatic occurrance of fomocaino metabolites in the
      rat].

PMID- 1036624
TI  - [Clinical cases of indicative, symptomatic superficial veinitis].

PMID- 1036625
TI  - [Social significance of psychogenesis and its basis].

PMID- 1036626
TI  - [Experimental studies on the mechanism of convulsive seizure--changes of the
      patterns of seizure and seizure activity during maturation (author's transl)].

PMID- 1036627
TI  - [Non-syphilitic venereal diseases].

PMID- 1036628
TI  - [Anti-venereal legislation].

PMID- 1036629
TI  - [Surgical treatment of Basedow's disease].
AB  - Specific surgery of Graves' disease in the patient prepared by prior medication
      is a low-risk method of treatment. Subtotal thyroidectomy can be regarded as a
      specific therapeutic procedure which brings about a prompt euthyroid status.
      Mandatory and circumspect exposure of the recurrent nerves affords greater
      certainty of avoiding damage to them.

PMID- 1036630
TI  - [Radioiodine treatment in Basedow's disease].
AB  - Radioiodine (131I) is the standard treatment for hyperthyroidism with Graves'
      disease because of ease of performance, relatively low cost and minimal
      complications. The patient must be followed up regularly at 1-2 year intervals
      although the risk of "early myxedema" (less than 3%) and the cumulative myxedema
      rate (less than 2% per year) are now minimized thanks to smaller single doses of
      radioiodine and to an individualized scheme for dose calculation. For patients in
      poor condition, 131I should be combined with thyrostatic therapy for at least 2
      1/2 months.

PMID- 1036631
TI  - Shock lung and respiratory function.

PMID- 1036632
TI  - [Human alveolar surfactant in histochemical studies].

PMID- 1036633
TI  - [Deficiency of surfactant in the newborn: pulmonary hyaline membrane disease].

PMID- 1036634
TI  - [Termination of chronic lymphoid leukemia--Richter's syndrome].

PMID- 1036635
TI  - [Treatment of internal hemorrhoids by the method of nonsurgical ligature combined
      with proctoglivenol].
AB  - In the Research Laboratory of Proctology with the clinic of the RSFSR Ministry of
      Health since 1974 a nonoperative ligature method was employed for treatment of 50
      patients at high risk for this affection. A combined use of the nonoperative
      method and proctoglivenol suppositories is a rather effective therapeutic
      measure, which is indicated for treatment of hemorrhoids in patients, in whom
      operative intervention is contraindicated.

PMID- 1036636
TI  - The use of a technicon SMA 12/60 multichannel biochemical analyzer in veterinary
      clinical pathology.
AB  - This article has described many of the advantages of using a sequential
      multichannel autoanalyzer to obtain a biochemical profile on animal blood
      specimens and how this profile can be used in assessing the patients biochemical
      status. Precautions concerning the collection of blood samples to avoid spurious
      results have been emphasized. Hemolysis should, in particular, be avoided.
      Ideally, plasma should be separated from cells shortly after collection and
      refrigerated. If this is not possible, storage of whole blood under refrigeration
      (4 degrees C.) is permissible for a short period. In these cases minor changes in
      blood glucose, total CO2, and calcium may be expected. Also presented are some of
      the statistical calculations and manipulations that are possible utilizing a data
      bank containing the data from the SMA 12/60. This information is being used to
      update much of our knowledge of veterinary clinical pathology.

PMID- 1036637
TI  - Laboratory diagnosis of pleural and peritoneal effusions.

PMID- 1036638
TI  - [Ultraviolet fluorescence of the blood serum in rats with transplanted
      lymphosarcoma].

PMID- 1036639
TI  - [Primary malignant tumours of the small intestine (author's transl)].
AB  - In the years between 1936 and 1973 19 patients with malignant tumours of the
      small intestine were admitted to the 2nd Department of Surgery, University of
      Vienna. Analogous to the findings of large-scale investigations adenocarcinomas
      (7 cases) preponderate in the upper small intestine in our case material, while
      lymphosarcomas and carcinoids mainly occur in the ileum. A radical surgical
      procedure was possible in 11 cases. The adenocarcinomas have the most
      unfavourable prognosis, whilst survival times of up to 10 years were found with
      lymphosarcomas and carcinoid tumours.

PMID- 1036640
TI  - [The lung phospholipid content in newborn infants with idiopathic respiratory
      distress syndrome in relation to lung histology and survival time (author's
      transl)].
AB  - In an autopsy series on 25 newborn infants who died in the perinatal period (19
      with and 6 without respiratory distress syndrome [RDS]) the total phospho-lipid,
      lecithin, and sphingomyelin content was determined in lung homogenates as
      parameters of the surfactant content. Histologically, the newborn infants with
      RDS were subdivided into those with and those without hyaline membranes. Newborn
      infants with RDS hat a lower lung phospho-lipid content than mature newborn
      infants without RDS but there was no difference in phospholipid content in
      relation to the presence or absence of hyaline membranes. The lecithin content of
      the lungs in those infants with RDS who had survived for more than 24 hours was
      higher in the absence of hyaline membranes than in their presence.

PMID- 1036641
TI  - [Clinical significance of compensated autonomic thyroid-gland adenoma].

PMID- 1036642
TI  - [Psychopathological syndromes in organic diseases].

PMID- 1036643
TI  - [Effect of antirheumatic agents on DNA-systems and DNA repair of various cell
      systems].

PMID- 1036644
TI  - [Residues of chlorinated hydrocarbons in milk and milk products - situation and
      evaluation (author's transl)].
AB  - Residues of the most varied chemical substances can be found in milk and in milk
      products. For the transfer into milk such factors as fat solubility, persistance
      with respect to metabolic processes and accumulation capacity in certain organic
      systems are of particular importance. For the description of the situation with
      respect to residues of chlorinated insectides the results of analyses obtained in
      20 supply areas of the German Federal Republic are presented and interpreted. In
      1974 the following mean values were found (fat basis): alpha-HCH 0.04, gamma-HCH
      0.072, heptachloro-epoxide 0.024, dieldrin 0.021 and DDT 0.20 ppm. These mean
      values are far below the max. quantities legally permissible and in no way
      constitute a toxicological risk (referred to ADI). In the German Federal Republic
      the concentrations of hexachlorobenzene in some cases reach the permissible max.
      quantity of 0.5 ppm on a fat basis. There is reason to assume that this substance
      finds its way into the milk not only via its application as a fungicide but
      probably also via a number of other, in part unknown, sources of contamination in
      or on vegetable products. With PCB (polychlorinated biphenyls) average
      concentrations from 0.2 to 0.3 ppm must be expected to be present in milk and
      milk products (fat basis). At present a toxicological interpretation of the
      values found is hardly possible.

PMID- 1036645
TI  - The first international standard for human urinary FSH and for human urinary LH
      (ICSH), for bioassay.
AB  - This paper describes the preparation and nature of the First International
      Standard for Human Urinary Follicle Stimulating Hormone and for Human Urinary
      Luteinizing Hormone, for Bioassay, and of two batches of working standard which
      were prepared from the same material. A collaborative study of these materials
      was carried out by six laboratories in six different countries. The FSH and LH
      activities of the Standard were assayed in terms of those of the Second
      International Reference Preparation of Human Menopausal Gonadotrophins, Urinary,
      for Bioassay, which it replaces. The results from 20 valid FSH assays and 30
      valid LH assays (using four different methods) obtained in this way gave a
      weighted combined potency estimate for FSH of 53.7 IU, with 95 % fiducial limits
      of 47.2-61.1 IU, and for LH of 46.2 IU, with 95 % fiducial limits of 43.3-49.3
      IU. Accelerated degradation studies of the Standard stored at elevated
      temperatures suggested that the stability of both FSH and LH activities under
      normal storage conditions would be satisfactory. The FSH and LH activities of the
      two batches of working standard (WS-A and WS-B) were compared with those of the
      Standard and were not found to differ significantly, except for the LH activity
      of WS-B which appeared to be slightly higher than that of the Standard.
      Accelerated degradation studies did not show any significant differences in
      stability between the Standard and batches of working standards. On the basis of
      these results the Standard has been established by WHO and allocated a potency
      for FSH of 54 IU per ampoule and for LH 46 IU per ampoule. The International
      Units for FSH, Human Urinary, for Bioassay and for LH (ICSH), Human Urinary, for
      Bioassay are thus defined as the activities contained in 0.1138 mg and 0.13369 mg
      of the International Standard, respectively.

PMID- 1036646
TI  - Prolactin in the ram: seasonal variations in the concentration of blood plasma
      from birth until three years old.
AB  - Peripheral prolactin levels were measured by radioimmunoassay in nine Ile de
      France rams, born in autumn and reared under natural conditions of light and
      temperature until three years old. During December, when the rams were 80-100
      days old, a brief and transitory peak of prolactin occurred (70 ng PS6/ml plasma
      +/- 10 ng). During each following year, the prolactin level fell in winter to
      approximately 20 ng/ml. However, in summer the prolactin was 4 times higher than
      the winter level during the first year and 11 times higher during the 2nd and 3rd
      years. A possible role of prolactin variation throughout the breeding season is
      discussed.

PMID- 1036647
TI  - Thyroid hormone response to varying doses of TSH.
AB  - Fifty-five normal subjects were studied following intravenous injection of
      increasing doses of bovine thyrotropin (b-TSH) from 0.5 to 250 mU/kg. Serum
      triiodothyronine (T3) and thyroxine (T4) were measured 1, 2, 3 and 4 h after the
      TSH injection. Dose-related increments in serum T3 and T4 were demonstrated with
      doses of b-TSH = 2.5 mU/kg and a maximum response was obtained after
      approximately 100 mU/kg. The fractional increase in serum T3 was greater than in
      serum T4, but the ratio between the increase in serum T4 and serum T4 and serum
      T3 (21.3/l ng/ng) was independent of the dose of b-TSH and time after TSH
      stimulation. The T3 response was reproducible and unaffected by sex and age.

PMID- 1036648
TI  - Dynamic study of post-natal thyroid function in the rat.
AB  - The thyroid function in development was investigated in post-natal rats. The
      thyroid iodine content rapidly increased from birth (137 +/- 26 ng iodine/mg
      thyroid) up to day 10 (338 +/- 42 ng iodine/mg thyroid) then increased more
      slowly up to day 30 (425 +/- 34 ng iodine/mg thyroid). The maximal plasma
      concentration of thyroxine was observed on day 16 (56.9 +/- 3.5 ng T4/ml) and of
      iodide on day 10 (110.2 +/- 12.6 ng I-/ml). The turnover rate constant of
      extrathyroidal thyroxine was higher at birth (8.0 +/- 2.3 %/h) than at any older
      age studied (average 6 %/h). Thyroxine secretion by the thyroid was more intense
      before weaning (37 ng hormonal iodine/h/100 g body weight on days 10 and 20) than
      after weaning (22 +/- 6 ng hormonal iodine/h/100 g body weight in 30 days old
      rats). The peripheral deiodination rate of thyroxine represented about 90 %
      thyroxine secretion rate in newborn and 10 days old rats and only 40% in adult
      females. In pre-weaning rats, after a single injection of both [131I]L-T4 and
      [125I]Na, extrathyroidal radioactivity disappeared more slowly than in 30 days
      old rats and adult animals. This suggests that iodide concentrations of
      extrathyroidal tissues are higher before than after weaning.

PMID- 1036649
TI  - Antigoitrogenic effect of casein.
AB  - Epidemiological findings from the city of Cali, Colombia, support the hypothesis
      that water supply and iodine intake are not the only dietary factors which
      influence the magnitude of the goitre endemia. Experiments were conducted in rats
      to determine whether casein has a counteracting effect on the goitrogenic and
      antithyroid activities of methimazole (MMI) and goitrogenic water extracts (GWE)
      from the endemic area of the Cauca Valley. Female albino rats (Charles River, DC
      strain) 100-110 g initial weight, receiving 12 mug of iodine daily, were divided
      into three groups annd put on special diets: protein-free, 8 % casein, or 60 %
      casein, respectively. Each group (24 rats) was then divided into three subgroups.
      Subgroup one received goitrogen-free water and was used as a control. Subgroup
      two was administered MMI, 50 mug/day/rat. Subgroup three was given per animal a
      daily amount of GWE equivalent in antithyroid potency to 50 mug of MMI. At 77
      days, the thyroid glands were studied for weight, 131I uptake, and 127I
      concentration. Animals on the protein-free diet showed significantly (P less than
      0.05 - less than 0.01) larger thyroid glands per 100 g body weight and lower
      thyroidal 4 h 131I uptake and 127I-concentrations than rats on casein diets.
      These differences were significantly increased (P less than 0.01) by the
      administration of MMI and GWE. All the effects were completely reversed by the 60
      % casein diet showing no differences between control rats and those on MMI or
      GWE. Rats on 8 % casein showed intermediate values between those of animals on
      protein-free and 60 % casein diets; differences were still present between the
      control as against the MMI or GWE groups, The results indicate that under these
      experimental conditions, a poor-protein diet impairs the thyroidal transport of
      iodine, decreases its concentration in the thyroid and is accompanied by an
      enlargement of the gland. Under these circumstances, the action of thiourea-like
      antithyroid agents is enhanced. The administration of protein reverses these
      alterations and decreases the action of such antithyroid agents. Whether the
      changes observed are due to a direct action of casein on the thyroid and/or to
      effects of malnutrition on the metabolism of antithyroid compounds remains to be
      determined.

PMID- 1036650
TI  - The effect of atropine on the insulin release caused by oral and intravenous
      glucose in human subjects.
AB  - Oral and intravenous glucose tolerance tests were performed on normal fasting
      subjects, with and without atropine. Insulin release after oral glucose was
      significantly diminished by atropine, and this effect could not be ascribed to
      the drug delaying glucose absorption. However, insulin release brought about by
      intravenous glucose was not altered by atropine. Possible interpretations of
      these results are discussed.

PMID- 1036651
TI  - The distribution of blood flow to the reproductive tract of anaesthetized ewes
      near oestrus.
AB  - Radioactive microspheres were used to measure the rate and distribution of blood
      flow to the reproductive tract of anaesthetized sheep. Seven sheep were examined
      on day 14, 6 on day 15 and 10 on day 16 of the oestrous cycle: oestrus is
      normally on day 16 or 17. The rate of blood flow to the myometrium, endometrium
      and oviducts increased by 2-fold from day 14 to 15: the weights of these organs
      increased on day 16. Blood flow to the vagina and cervix increased by over 10
      fold from day 14 to 15 but vaginal and cervical weights remained unchanged.
      Thirty minutes after the administration of 1200 IU PMSG, blood flow increased in
      the vagina and cervix on day 14, the myometrium on day 15 and the vagina, cervix
      and oviducts on day 16. However, these results must be viewed with caution since
      there were substantial, though not significant changes in the controls. The
      results favour the hypothesis that, near the end of the oestrous cycle, oestrogen
      has a dominant role in the control of blood flow to the reproductive tract of
      sheep.

PMID- 1036652
TI  - Cytosol and nuclear [3H]oestradiol binding in the foetal tissues of guinea pig.
AB  - The formation of [3H]oestradiol macromolecule complexes was studied in vivo and
      in vitro in the kidney, lung and liver of intact foetal guinea pig. Specific
      binding of [3H]oestradiol was demonstrated in the cytosol and nuclear fractions
      of foetal kidney. Intensive binding was found in the cytosol of foetal lung but
      most of the bound radioactive material (70 %) was [3H]oestrone. Some binding was
      found in the cytosol of foetal liver but not in the nucleus of this tissue. In
      the in vivo experiments, the binding of radioactive material to plasma proteins
      was studied: 22 % of the plasma radioactivity was bound of which 67 % was
      identified as oestrone sulphate. Oestradiol sulphate represented 7% and
      unconjugated oestradiol only 0.6 % (0.1 % of the total plasma radioactivity). On
      the other hand, 2-3 % of the foetal plasma radioactivity was found as unbound
      [3H]oestradiol. In the kidney, the formation of [3H]oestradiol complexes in the
      cytosol fraction does not depend on temperature while nuclear [3H]oestradiol
      complexes increase with increasing temperature. Maximal formation of
      [3H]oestradiol complexes in the cytosol fraction and the 0.1 M TRIS and 0.3 M
      NaCl nuclear extracts was reached after 15 min but binding in the 1 M NaCl
      nuclear extract continued to increase up to 30 min. After incubation of purified
      nuclei of foetal kidney with 1.1 x 10(-7) M [3H]oestradiol, specific binding was
      found in the different nucelar fractions. Specific binding was also detected in
      isolated nuclei previously extracted by 0.1 M TRIS and 0.3 M NaCl before being
      incubated with 1.1 x 10(-7) M [3H]oestradiol. The Kd of binding of [3H]oestradiol
      in the renal cytosol fraction is 2.5 x 10(-10) M with n = 4.5 x 10(-14) moles/mg
      protein. Incubation of isolated 1 M NaCl nuclear extract from foetal kidney with
      [3H]oestradiol gives a Kd of 3.3 x 10(-10) M with n = 2.5 x 10(-14) moles/mg
      protein. It is concluded that the nuclear complexes in the foetal kidney could be
      formed either through an intermediate cytosol complex or that the "two step"
      mechanism could take place in the nucleus. Furthermore, direct binding of
      [3H]oestradiol with high affinity was observed in the 1 M NaCl nuclear extract.

PMID- 1036653
TI  - Studies in congenital generalized lipodystrophy. IV. Effect of muscular exercise
      on carbohydrate and fat metabolism including plasma levels of IRI and HGH.
AB  - Two patients with congenital generalized lipodystrophy have been studied at rest,
      and during and after long-term exercise at different carefully measured work
      loads. The two patients represented different stages of diabetes development.
      Both patients derived most of their energy used during muscular exercise from
      carbohydrate, and comparatively little from fat. FFA levels remained low
      throughout the period of observation in contrast to normal individuals and
      patients with juvinile diabetes. The data presented seem to show that deposition
      of glucose and free fatty acids (FFA) as triglyceride, must be impaired and are
      not compatible with the concept of increased triglyceride turnover in the
      adipocytes. The fall in blood glucose concentration (BCG) was less than in normal
      individuals and juvenile diabetes during exercise, and the glucose tolerance
      remained unchanged following work stop in both patients (k-values unchanged), in
      contrast to normal persons and patients with juvenile diabetes. Both patients
      showed significant falls in circulating immuno-reactive insulin (IRI) levels
      during exercise irrespective of a rise or fall in BGC. Thus, the exercise itself
      might activate endogenous mechanisms which could, on the one hand increase the
      circulating BGC, and at the same time force circulating IRI to decrease, thus
      disturbing the well-known relationship between circulating glucose and IRI levels
      as has been exhibited in normal subjects. The high IRI levels, also during
      exercise in these patients, indicate a relative insulin resistance in the
      muscles, but less marked than the insulin resistance in the adipose tissue. The
      IRI response after glucose infusion did not change significantly with increasing
      work loads with one exception. Exercose did not alter significantly the human
      growth hormone (HGH) levels in either the diabetic or the non-diabetic patient
      indicating an abnormal regulation of the HGH secretion in congenital
      lipodystrophy.

PMID- 1036654
TI  - Changes in amniotic fluid phospholipids on treatment with glucocorticoids to
      prevent respiratory distress syndrome.
AB  - Amniotic fluid was obtained by transabdominal amniocentesis in 51 women in the
      29th-36th week of pregnancy. The lecithin/sphingomyelin ratio was determined. In
      28 patients,the ratio was less than 2.2. Beta-methasone was given for three days
      to 14 of them; the rest served as controls. On the fourth day, a second
      amniocentesis was performed on all patients. The lecithin/sphingomyelin ratio
      rose to a value greater than 2.2 in 4 of the patients in the betamethasone
      treated group and in one of the controls. The percentage of palmitic acid in the
      lecithin increased concomitantly with increasing lecithin/sphingomyelin ratio.
      These results suggest that glucocorticoid induced acceleration of fetal pulmonary
      maturation may be reflected in the amniotic fluid as changes in its phospholipid
      composition. The lecithin/sphingomyelin ratio was found to be greater than 2.2 in
      23 patients at the first amniocentesis. In such cases treatment with
      glucocorticoids can be avoided.

PMID- 1036655
TI  - [Peridural injection of corticosteroids in the treatment of the low back pain
      sciatica syndrome].

PMID- 1036656
TI  - [236 meniscectomies performed at DISCCA, Brussels].

PMID- 1036657
TI  - [Treatment of meniscal lesions].

PMID- 1036658
TI  - [Repeat exploratory arthrotomy of the knee].

PMID- 1036659
TI  - [Cystic degeneration of the external meniscus].

PMID- 1036660
TI  - Changes in erythrocyte lipid stroma in the premature infant according to dietary
      fat composition.
AB  - Eighteen premature infants of similar gestational age, divided into three groups,
      were fed 3 milk formulas containing different amounts of linoleic acid. All the
      cases received 120 calories per kg of weight and day, of which formula A supplied
      6.1% of the dietary total calories as linoleic acid, formula B 15.9% and formula
      C only 0.6%. The fatty acids of red cell ethanolamine and choline
      phosphoglycerides were studied in a first sample obtained during the first hours
      of life before the infants had received any food, and in a second sample taken at
      the age of three weeks. In the group fed formula C (0.6% of the total calories)
      changes similar to those described in EFA-deficient rats were found, namely, a
      decrease of linoleic acid, and an increase of oleic acid and of 20:3 (n-9), with
      a consequent rise of the triene to tetraene ratio. When the supply of linoleate
      was highest (15.9% of the total caloric intake) linoleic acid increased, oleic
      acid decreased and the 20:3 (n-9) practically disappeared. None of the three
      groups showed any clinical symptoms.

PMID- 1036661
TI  - Oxisuran: a non-cytotoxic, differentially immunosuppressive agent.

PMID- 1036662
TI  - Bromocriptine:dopamine-receptor agonist.

PMID- 1036663
TI  - Nitrogen retention and plasma amino acids of adults who consumed isonitrogenous
      diets containing rice and milk or wheat versus their constituent amino acids.
AB  - Nitrogen retention and concentrations of plasma amino acids were compared when
      young adults consumed isonitrogenous diets containing proteins (3.0 g of N from
      rice plus 3.0 g of N from milk or 3.0 g of N from rice plus 3.0 g of N from wheat
      flour) or mixtures of their constituent amino acids. Diets containing proteins
      induced greater nitrogen retention than did those containing corresponding
      amounts of amino acids in crystalline form, and the difference between the
      combinations of proteins was delineated more sharply. Concentrations of several
      amino acids were elevated by substituting crystalline amino acids for proteins,
      especially in postprandial plasma. Subjects responded differently to addition of
      the limiting amino acids, lysine and tryptophan, to the diets containing amino
      acids instead of rice plus wheat. Therefore, data obtained by means of
      combinations of cereals and by mixtures of their constituent amino acids cannot
      always be used interchangeably.

PMID- 1036664
TI  - Ischemia of the small intestine.

PMID- 1036665
TI  - Gynecologic disease in young, sexually active women.
AB  - There has been a significant change in adolescent sexual behavior in the past
      decade. This report of 1,594 young, sexually active women, primarily from middle
      and upper socioeconomic backgrounds, identifies the obstetric and gynecologic
      problems characteristic of the group. While supposedly in a low-risk category
      these patients displayed a high incidence of cervical epithelial abnormality,
      problem pregnancy, and other obstetric and gynecologic abnormality. The incidence
      of veneral disease  was somewhat lower than anticipated.

PMID- 1036666
TI  - [Presence of a new lymphoid organ in some teleosts].

PMID- 1036667
TI  - 125I therapy in Graves' disease. Long-term results in 355 patients.
AB  - Because of the physical and radiobiologic differences between 125I and 131I, a
      trial using 125I to treat hyperthyroidism was undertaken in the hope of
      controlling hyperthyroidism without causing subsequent hypothyroidism. Three
      hundred fifty-five patients with diffuse toxic goitres were treated and have been
      under review for an average of 49.4 months:  63.4% are euthyroid, 33.5% are
      hypothyroid, and 3.1% remain hyperthyroid. Different groups of patients received
      a wide range of doses of 125I (4.0 to 56.0 mCi), and the lowest incidence of
      hypothyroidism (23%) was in the group that received between 6.0 and 10.5 mCi.
      Sixty-three percent of the patients whose initial dose was greater than 20.0 mCi
      are hypothyroid. Persistent hyperthyroidism was common in patients who received
      small doses. Because of the high incidence of posttreatment hypothyroidism in
      this series and because 131I has stood the test of time, we believe that 131I is
      the radionuclide of choice for the routine treatment of hyperthyroidism.

PMID- 1036668
TI  - Antibodies to Yersinia enterocolitica in thyroid disease.
AB  - The prevalence of elevated antibody titers against Yersinia enterocolitica was
      studied in normal subjects, patients with a variety of nonthyroidal illnesses,
      and patients with thyroid disease. In contrast to the low prevalence of
      antibodies in controls (less than 8%), 48 of 67 patients (75%) with a variety of
      thyroid disorders had titers greater than 1:8. Antibodies were found in 24 of 36
      patients with Graves' disease, five of six with autonomous adenoma, seven of
      seven with Hashimoto's thyroiditis, three of five with idiopathic primary
      hypothyroidism, four of 11 with nontoxic nodular goiter, and one of two with
      thyroid carcinoma. Antibodies to serotype 3 were the most prevalent, occurred in
      the highest titers, and were found particularly in patients with Graves' disease.
      These observations indicate that in spite of the infreqent occurrence of yersinia
      infection in the United States as compared with Scandinavia, patients with
      thyroid disorders have a higher prevalence of antibodies to Yersinia than normal
      subjects or patients with other disorders.

PMID- 1036669
TI  - Hashimoto's thyroiditis, myasthenia gravis, idiopathic thrombocytopenic purpura.

PMID- 1036670
TI  - Prolonged rupture of membranes, pre-eclamptic toxaemia, and respiratory distress
      syndrome.
AB  - A retrospective analysis was made of the incidence and severity of the idiopathic
      respiratory distress syndrome (RDS) in babies of less than 35 weeks' gestation
      born at this hospital from January 1967-December 1974. There was a lower
      incidence of RDS in babies born after pregnancies complicated only by prolonged
      rupture of membranes (PRM) (19%) and in babies born vaginally after pregnancies
      complicated only by pre-eclamptic toxaemia (PET) (18%) compared with the
      incidence of RDS after uncomplicated pregnancies (35%). Babies born vaginally who
      developed RDS after pregnancies complicated by PRM or PET had less severe disease
      compared with those who developed RDS after uncomplicated pregnancies. Mortality
      in babies who developed severe RDS was not influenced by the occurrence of PRM or
      PET. The biological implication of the study is that certain complications of
      pregnancy may accelerate pulmonary surfactant production in preterm babies.

PMID- 1036672
TI  - The future of the Atlas of Tumor Pathology.

PMID- 1036671
TI  - Intrathecal antibiotic therapy for neonatal meningitis.
AB  - Twenty infants with neonatal meningitis were treated with systemic and lumbar
      intrathecal antibiotics upon initial diagnosis. Failure to sterilize the CSF in 2
      3 days was associated with evidence of ventriculitis in these infants who were
      then treated with intraventricular antibiotics. 4 infants died, but only 2 of
      them may be regarded as treatment failure. It is suggested that many deaths from
      neonatal meningitis may be preventable by early detection and treatment of
      ventriculitis with intraventricular antibiotics.

PMID- 1036673
TI  - Acute renal failure following halothane anesthesia.
AB  - Acute renal failure was observed postoperatively in a patient after halothane
      anesthesia. The clinical and pathologic findings in this case were remarkably
      similar to those found in patients with renal failure after methoxyflurane
      anesthesia.

PMID- 1036674
TI  - Abnormal vessels in the urinary tract following analgesic abuse in man.
AB  - A brownish discoloration of the bladder mucosa around the ureteric orifices has
      been observed on cystoscopy in three patients taking excessive quantities of
      analgesics. Biopsy specimens revealed an unusual degree of hyalinization of the
      vessels in the submucosa. Similar changes have been noted in the renal medulla,
      pelvis, and ureter of patients with classical analgesic nephritis. This vascular
      change may play an important part in the development of the characteristic
      infarct-like necrosis seen in the analgesic kidney.

PMID- 1036675
TI  - Pulmonary injury and repair. Organ culture studies of murine lung after oxygen.
AB  - Samples of mouse lung were cultured at various stages of the injury-repair cycle
      induced by oxygen. At intervals during and after a six-day exposure, pulmonary
      explants were prepared and cultured in media labeled with tritiated thymidine.
      Lungs cultured during the first three days in oxygen, when only interstitial
      edema was observed, resembled control explants in morphologic features and
      labeling. Cultures prepared from animals after four to six days of exposure, when
      necrosis of type 1 epithelial cells and hyaline membranes were observed, showed
      reduced thymidine uptake and reduced epithelial regeneration. Fibroblastic
      proliferation and collagen deposition occurred directly beneath areas with
      hyaline membranes, indicating that, in severely damaged lungs, cellular
      proliferation is predominantly fibroblastic rather than epithelial. The results
      suggest that the organ culture system is suitable for studying the reparative
      capacity of injured tissue.

PMID- 1036676
TI  - Primary pulmonary neurilemoma. Report of a case with ultrastructural examination.
AB  - The electron microscopic features of a primary neurilemoma of the lung, a very
      rare neoplasm, were studied. Characteristic Schwann cells were present, with
      cytoplasm and elongated cytoplasmic processes coated with a basal lamina. The
      highly characteristic Luse bodies were also seen. We add electron microscopic
      corroboration to the previous tissue culture confirmation of this unusual benign
      pulmonary neoplasm.

PMID- 1036677
TI  - Tubular stenosis of the aorta with aortic fibromuscular dysplasia.
AB  - The autopsy findings in a 2-year-old girl with severe hypertension resulting from
      stenosis of the lower part of the thoracic and the abdominal aorta were reviewed.
      The lower portion of the thoracic aorta and the abdominal aorta showed uniform
      narrowing down to the level of the bifurcation of iliac arteries. Histologically,
      the aortic wall of the stenotic site showed irregular proliferation of smooth
      muscle cells and collagen fibers. The elastic fibers had disappeared from outside
      the media. No intimal thickening and inflammatory cell infiltration were
      observed. These histologic changes of the aortic media in this case are
      apparently similar to fibromuscular dysplasia (medial hyperplasia).

PMID- 1036678
TI  - Identification of calcium oxalate deposits in bone by electron diffraction.
AB  - Oxalosis involving bone secondary to prolonged chronic renal failure and long
      term dialysis occurred in a living patient. The cystalline deposit in the small
      fragment of bone was identified by electron diffraction.

PMID- 1036679
TI  - Wilson disease. Comparative ultrastructure in a sibship of nine.
AB  - Comparative electron microscopy was done on liver tissue from a family of nine
      siblings to determine whether presymptomatic, affected patients with Wilson
      disease could be differentiated from heterozygous, normal carriers. Two of the
      nine had developed the neurologic manifestations of the disease; three others
      were considered to be homozygous but normal, two were heterozygous and normal,
      and two were classified as genotypically uncertain because of borderline
      biochemical abnormalities. Alterations of the mitochondria and endoplasmic
      reticulum suggestive of copper toxicity were present in both the heterozygous and
      the genotypically uncertain siblings, and a clear distinction could not be made
      on this basis. The severity of the abnormalities appeared to correlate with liver
      copper level, and organelle changes were found to precede lipid accumulation.

PMID- 1036680
TI  - Meningioma with sarcomatous change and hepatic metastasis.
AB  - A 72-year-old patient had a meningotheliomatous meningioma that invaded through
      the skull and into temporalis muscle. One year following craniotomy for removal
      of the neoplasm, he developed headaches, diplopia, and proptosis of the left eye.
      Biopsy of the orbital contents revealed a malignant supporting tissue neoplasm
      having a resemblance to the previous meningioma. No curative therapy was possible
      and the patient died 33 months after diagnosis. Autopsy examination showed
      extensive residual intracranial neoplasm and a 3-cm metastasis in the liver. The
      metastatic tumor appeared similar to the meningioma and did not appear malignant
      histologically. The case illustrates the distinct histologic variations in
      meningiomas and the difficulties in predicting their biologic activity.
      Aggressive local behavior may indicate possible malignant areas in the neoplasm.
      Therefore, examination of the neoplasm should be thorough. Such a correlation may
      suggest malignant biologic potential.

PMID- 1036681
TI  - [Local pO2- and pH2-measurements with needle electrodes for the examination of
      the hydrogen maintenance and microcirculation of the cochleae (author's transl)].
AB  - The local partial pressure of oxygen (pO2) and the rate of hydrogen elimination
      were measured in the three scalae of the basal turn of 28 Guinea-pig cochleae
      under conditions of normoxia, hyperoxia and hypercapnia and with acoustical
      stimulation with the needle electrodes developed by Baumgartl and Lubbers. In the
      scala tympani a pO2 decrease from the round window toward Corti's organ was
      registered and pO2 values of over 100 mm Hg were measured near the membrane of
      the round window and of 10-40 mm Hg near the basilar membrane depending on how
      deeply the electrode penetrated into the scala tympani. The pO2 profiles were
      changed or reversed when the animal breathed a mixture of 95% oxygen and 5%
      carbon dioxide and when the round window membrane was covered with agar-agar or
      paraffine and exteriorly flooded with nitrogen. Acoustical stimulation with a
      white noise of 85 dB caused a considerable pO2 drop in the perilymph of the scala
      tympani while in the endolymph of the scala media we observe only a slight
      decrease. Intravenous application of dextran of low viscosity leads to a pO2
      increase when the original oxygen value in the scala tympani was low. The half
      life of hydrogen in the scala tympani amounts to about 4 min. The results permit
      the conclusion that, in the area of the cochlear basis, Corti's organ receives
      its oxygen supply via the capillary system as well as via the membrane of the
      round window.

PMID- 1036682
TI  - [On the practice of audiological balance-tests (author's transl)].
AB  - The psychological factors influencing the common test-situation of the ABLB are
      still unknown. The fact that always on the same ear the intensity is remaining
      constant and that this intensity is increased in equal steps is no longer due to
      modern psychological principles of testing. Both--the side and the intensity-
      should be randomized within the given range (both sides and all possible
      intensities). Therefore the test-procedure is controlled by a computer, which
      also calculates the significance of the relative recruitment. When the test is
      finished a diagram is plotted containing the values and the regressionline. Also
      the monaural test (comparison of two frequencies) is well practicable using the
      same program, because the incertainty (being greater if the test is more
      difficult) is included in the statistic calculation.

PMID- 1036683
TI  - A comparison of acidic glycosaminoglycans in the inner ear and other organs:
      electrophoretic microanalysis.
AB  - Acidic glycosaminoglycans in the ground substance of the membranous cochlear
      lateral wall, kidney, brain and liver of the guinea pigs were quantitatively and
      qualitatively analyzed, using electrophoretic microanalysis. The lateral wall of
      the cochlea showed highest content (0.46 +/- 0.08%/D.W.) of acidic
      glycosmainoglycans, which were chondroitin sulfate-B (75%), chondroitin sulfate-A
      (12%) and hyaluronic acid (13%). However, the pattern of these acidic
      glycosaminoglycans in the inner ear differed from the other organs. A possible
      role of acidic glycosaminoglycans in the inner ear was discussed.

PMID- 1036684
TI  - [Aerosinusitis (author's transl)].
AB  - After distinguishing a nonobstructive from an obstructive form of aerosinusitis,
      different pathological changes are discussed. Two cases illustrate the
      possibility of endoscopic removal of submucous sinus hematomas. Nonobstructive
      aerosinusitis may be due to highly viscous paranasal secretion. In obstructive
      sinus disease intranasal application of vasoconstrictors may prevent additional
      aerosinusitis. In 71 patients with obstructive frontal and maxillary sinusitis,
      aerosinusitis followed a negative sinus pressure of 66 mm Hg and 35 mm Hg
      respectively. Intranasal application of a vasoconstrictive and antiexsudative
      solution for prophylaxis of aerosinusitis lead to an increase of negative
      pressure tolerance of 47-57 mm Hg.

PMID- 1036685
TI  - Osmotic relation between blood and perilymph in guinea pig.

PMID- 1036686
TI  - Permeability of round window membrane to 22Na or RISA.

PMID- 1036687
TI  - The damped pendular rotation test in central vestibular disorders.
AB  - Nystagmic rhythm in the damped pendular rotation test (DPRT) was analysed
      electronystagmographically both in healthy subjects (control) and patients with
      peripheral and central vestibular lesions. The patients were tested in a semi
      dark room with eyes open and, in addition, a serial subtraction task was
      performed to maintain the state of alertness throughout the rotation. In the
      controls 49 years of age and under dysrhythmia was found in 11%, while in persons
      50 years of age and over the abnormal rate was 29%. In patients with acoustic
      tumors, who had undergone surgery in which the translabyrinthine and middle fossa
      approach had been utilized, dysrhthmia was present post-operatively in only a few
      cases. In patients 49 years of age and under, operated on through the
      suboccipital approach, dysrhythmia was found post-operatively, or was at least
      more remarkable than pre-operatively in most cases. Nystagmic rhythm was, on the
      other hand, regular with cerebellar degenerative process or atrophy. Pre
      operative dysrhythmia in patients with cerebellar and cerebral tumors was in some
      cases post-operatively converted to regular rhythmic nystagmus in pendular
      stimulations. Therefore, in cerebellar and cerebral tumors, dysrhythmia was
      thought to be due to secondary effects in brainstem, as these tumors can cause
      intracranial hypertension and circulatory disturbances in surrounding brain
      tissues. In Meniere's disease and sudden deafness, dysrhythmia and salvos in DPRT
      were found in the age groups, 49 years of age and under and 50 years and over, as
      frequently as in the healthy and control group. In one case with Meniere's
      disease which showed dysrhythmia, labyrinthectomy was done. This surgical
      manipulation of the labyrinth did not eliminate dysrhythmia, though a temporary
      improvement was obtained. This result indicates that the dysrhythmia may be of
      central origin. These findings also suggest that nystagmic rhythm in DPRT with
      mental arithmetic is significant in assessing brainstem dysfunctions, when the
      age and state of alertness of the patient are taken into consideration, or when
      comparing the pre- and post-operative findings in intracranial lesions.

PMID- 1036688
TI  - Loss of a homologous group of proteins in a dominantly inherited ectodermal
      malformation.
AB  - Hair from mice bearing the dominantly inherited Naked trait (NN) and from normal
      (NN) mice of the same inbred strain was separated into its major protein
      components by standard techniques. The relative amounts of proteins in these
      components were then determined by a regression method from the amino acid
      composition of the hair samples and of the fractions into which they had been
      separated. The results indicated that the amount of soluble fibril in Naked-mouse
      hair is decreased. Polyacrylamide-gel electrophoresis of this fraction prepared
      from the hair of both normal and Naked mice revealed that all protein bands
      present in the normal are also present in the Naked mice. However, a
      densitometric scan of the gels at 280 nm showed that the soluble fibril fraction
      from Naked-mouse hair is deficient in several proteins which, on amino acid
      analysis, were found to contain 31% glycine and 10% tyrosine. Gel filtration of S
      carboxymethylkerateine prepared from normal and mutant hair showed that the
      mutant hair is deficient in a heterogeneous, low-molecular-weight fraction also
      rich in glycine and tyrosine. Our present data do not reveal the mechanism
      whereby a single gene locus modulates the production of several different
      proteins.

PMID- 1036689
TI  - Secretion and localization of cathepsin D in synovial tissues removed from
      rheumatoid and traumatized joints. An immunohistochemical study.
AB  - The proteinase cathepsin D which degrades proteoglycan was never demonstrated in
      extracellular sites in tissues from patients with traumatized meniscoid
      cartilage, either before or after culture with an antiserum to human cathepsin D.
      In contrast, in synovia (but not usually cartilage) from the knees of 6 of 11
      rheumatoid patients, extracellular cathepsin D was commonly detected by culturing
      tissues with an antiserum to this enzyme.

PMID- 1036690
TI  - A method for radioimmunological assay of glisoxepide (author's transl).
AB  - A radioimmunoassay for the antidiabetic drug 3-(4-[beta-(5-methyl-isoxazol-3
      carboxyamido)-ethyl]-benzenesulfonyl)-ureido-piperidine-4-carboxic acid
      (glisoxepide, I, Pro-Diaban) is described. Antisera were obtained by immunizing
      rabbits with a piperidine carboxylic acid analogue of glisoxepide coupled to
      bovine serum albumine. The carboxylic acid analogue coupled to [3H]-1-tyrosine
      methyl ester was used as the tracer. Antisera with high sensitivity were
      obtained. With some glisoxepide analogues the specificity of the antisera was
      investigated. For good binding the isoxazole and the benzene ring as well as the
      appropriate distance between both rings are essential. The assay can be carried
      out without extraction of the compound from the serum. Dextran coated charcoal is
      used for separation of free and bound glisoxepide.

PMID- 1036691
TI  - [Adenosine degradation in human erythrocytes in the presence of dilazep].
AB  - 1. In the molar end concentration of 1 X 10(-6), 1,4-bis-[3-(3,4,5
      trimethoxybenzoyloxy)-propyl]-perhydro-1,4-diazepine (dilazep) has no effect on
      crystalline adenosine desaminase. 2. In the same concentration dilazep does not
      affect adenosine desaminase activity of human hemolysing erythrocytes. 3. Under
      the influence of dilazep the methylene blue activated respiration of human
      erythrocytes is inhibited adenosine serving as substrate. a) The final molar
      concentration of 1 X 10(-7) leads to minor inhibition of the respiration. b)
      After transitory activation, final molar concentrations of 1 X 10(-6) and 1 X 10(
      5) also lead to inhibition, which is complete after 4 h and in which the
      concentration of 1 X 10(-6) has the most pronounced effect. 4. Basing on the
      experimental results obtained it is not yet possible to classify the mode of
      activity of dilazep.

PMID- 1036692
TI  - [On the mode of action of difenoxine (R15403). Part 1: Studies on isolated
      intestinal smooth muscle (author's transl)].
AB  - 1-(3-Cyano-3,3-diphenylpropyl)-4-phenyl-isonicotinic acid hydrochloride
      (difenoxine, R 15 403) in vitro acts directly on gastrointestinal smooth muscle.
      It inhibits spontaneous contractions, it antagonizes the histamin-induced
      contractions and partially inhibits acetylcholine. Compared with pethidine
      difenoxine appears 50 times more powerful.

PMID- 1036693
TI  - The effect of O-(beta-hydroxyethyl)-rutosides on function and structure of the
      ganglion cells.
AB  - The effect of O-(beta-hydroxyethyl)-rutosides (Venoruton) on function and
      structure of the motor anterior-horn cells of the lumbar spinal cord was
      investigated under conditions of ischemia in the rabbit. The determination of the
      functional parameters of the ganglion cells, such as maximal function time (Fm),
      disappearance time (SFm), relative efficiency (La), and regeneration expenditure
      (Ea) revealed that 50 mg/kg of Venoruton injected prior to repeated aortic
      occlusion of short duration (occlusion time A = Fm and A = 2 Fm, respectively)
      caused the efficiency of the anterior-horn cells to be decreased. Both
      qualitative and quantitative analysis of the mitochondrial structure after
      prolonged aortic occlusion (15-25 min) revealed that after prior injection of
      Venoruton irreversible structural changes in the mitochondrial membranes of the
      ischemic area in the spinal cord occurred after aortic occlusion of 15 min
      duration. In the untreated controls such changes were not observed before 20 min
      of occlusion. The mitochondrial structure of the non-ischemic area in the spinal
      cord was found to be undamaged, however, in both controls and experimental
      animals. Venoruton given after prolonged aortic occlusion resulted in less
      pronounced structural changes of the mitochondria in the ischemic area of the
      experimental animals than those found in the untreated controls; paralysis of the
      hind extremities was found to occur only after prolonged occlusion (25 min),
      whereas in the controls such changes were already observed after 20 min of
      occlusion. Since no ultrastructural changes in the ganglion cells of the non
      ischemic area in the in the lumbar spinal cord were observed after application of
      Venoruton, it is assumed that the decreased efficiency of the motor anterior-horn
      cells found in the ischemic area when Venoruton had been injected before the
      aortic occlusion may be due to reactions of the cell that only occur when the
      blood supply has been completely cut off and Venoruton is present at the same
      time.

PMID- 1036694
TI  - On the adrenergic neuron blocking activity of 1-methyl-3-keto-4
      phenylquinuclidinium bromide (MA540) during acute and chronic administration.
AB  - The quaternary quinuclidine derivative 1-methyl-3-keto-4-phenylquinuclidinium
      bromide (MA540) antagonized rabbit ileum and cat nictitating membrane responses
      to postganglionic sympathetic stimulation in a manner similar to guanethidine,
      indicating adrenergic neuron blocking activity. The potency of MA540 in relation
      to guanethidine varied according to the experimental procedure employed for
      assay, being equal to, less and greater than that of the reference agent in the
      rabbit ileum, and the acute and chronic nictitating membrane, respectively.
      Preferential blockade of nictitating membrane responses to both lower and higher
      frequencies of sympathetic stimulation were found with MA540 and guanethidine,
      depending on the dose used in acute experiments, or on the number of daily
      administrations in chronic tests. Significant tolerance to the adrenergic
      impairment induced by MA540 and guanethidine was not apparent in membranes
      subjected to supramaximal sympathetic stimulation, but was evident in membranes
      under the influence of normal sympathetic tone in unanesthetized cats. This
      phenomenon appeared much earlier with guanethidine than with the quinuclidine
      derivative. Tolerance was correlated neither with norepinephrine supersensitivity
      nor with catecholamine depletion, which was evaluated indirectly through
      measurement of membrane responses to tyramine. The results of this study indicate
      that MA540 may be a useful antihypertensive agent, possessing some advantages
      over guanethidine.

PMID- 1036695
TI  - Cardiovascular and antihypertensive actions of 1-methyl-3-keto-4
      phenylquinuclidinium bromide.
AB  - The sympatholytic and norepinephrine depleting drug 1-methyl-3-keto-4
      phenylquinuclidinium bromide (MA540) possessed significant chronic
      antihypertensive activity in mecamylamine- and renal-hypertensive dogs. The
      compound was approximately four times more potent than guanethidine in the former
      model and three times as potent in the latter. MA540 reduced orthostatic blood
      pressure responses in unanesthetized rabbits, but was approximately ten times
      less potent than guanethidine. The quinuclidine derivative did not affect cardiac
      output, heart rate or stroke volume in anesthetized open chest dogs and
      moderately increased mean blood pressure and total peripheral resistance. It
      produced diuresis and saluresis in anesthetized dogs, but did not influence water
      or electrolyte urinary excretion in conscious rats. In the latter test,
      guanethidine produced antidiuresis and antisaluresis. It was concluded that MA540
      is a potent, orally effective antihypertensive agent acting through adrenergic
      neuron blockade, that it lacks undesirable effects on cardiac and renal
      functions, and that compared with guanethidine, it is more potent in lowering
      blood pressure but less so in interfering with orthostatic cardiovascular
      reflexes.

PMID- 1036696
TI  - Influence of 1-methyl-3-keto-4-phenylquinuclidinium bromide on rat tissue
      monoamine levels in vivo.
AB  - The effects of 1-methyl-3-keto-4-phenylquinuclidinium bromide (MA540) on tissue
      monoamine levels in male rats have been compared to those of guanethidine.
      Neither compound influenced norepinephrine (NE) or 5-hydroxytryptamine (5-HT)
      levels in brain or epinephrine (E) levels in adrenal medulla. MA540 is about
      twice as potent as guanethidine as a heart NE depleting agent at both 8 and 24 h
      after drug administration. The durations of action of the compounds are similar.
      Unlike guanethidine, MA540 does not deplete NE in small intestine, which suggests
      that the drug may not elicit guanethidine-like intestinal side effects.

PMID- 1036697
TI  - The biological disposition of 1-methyl-3-keto-4-phenylquinuclidinium bromide in
      the rat and dog.
AB  - The biological disposition of 1-methyl-3-keto-phenylquinuclidinium bromide
      (MA540) has been studied in the rat and dog. Gastrointestinal absorption of the
      drug was considerably different in the 2 species; about 15% and 75% of the dose
      in the rat and dog, respectively. Tissue distribution after i.v. administration
      was characterized by generally high tissue/plasma drug ratios in the rat and by
      low plasma (the only tissue examined) levels in the dog. Drug localization was
      apparent in the liver and adrenals, and the highest average (24-h) concentration
      was found in those tissues. The distribution profile and the chemical nature of
      MA540 suggest that the compound was distributed, at least initially, in
      extracellular water. MA540 was not extensively metabolized by either species.
      Excretion, although initially fairly rapid, slowed such that whole body half
      lives were estimated to be 21 h and 47 h in the rat and dog, respectively.

PMID- 1036698
TI  - The acute and target organ toxicity of 1-methyl-3-keto-4-phenylquinuclidinium
      bromide (MA540) and guanethidine in the rat and dog.
AB  - The effects of acute and repeated increasing oral doses of 1-methyl-3-keto-4
      phenylquinuclidinium bromide (MA540) and guanethidine in the rat and dog have
      been described. On repeated oral administration guanethidine produced
      histopathological changes in cervical ganglia of rats and dogs which were clearly
      dose-dependent and reproduced lesions reported in the literature. Repeated oral
      administration of MA540 resulted in no histopathological changes in either
      species. The maximum tolerated oral dose for guanethidine was estimated to be 515
      mg/kg in the rat and 26 mg/kg in the dog compared with an estimated maximum
      tolerated oral dose for MA540 of 1750 mg/kg in the rat and 460 mg/kg in the dog.
      On the basis of these findings it is suggested that subchronic studies with MA540
      in the rat and dog should provide evidence which would justify the use of MA540
      in man at daily oral doses as high as 9 mg/kg.

PMID- 1036699
TI  - Anticatabolic action of formebolone in the castrated rat treated with
      dexamethasone.
AB  - The anticatabolic action of 2-formyl-17a-methylandrosta-1,4-diene-11a,17beta-diol
      3-one (formebolone) was demonstrated by assessing the nitrogen elimination in the
      urine of castrated rats treated with dexamethasone-21-phosphate. The absence of a
      virilizing action is duly pointed out.

PMID- 1036700
TI  - The absorption of [G-3H]-acetylglycyrrhetate after oral administration to rats.
AB  - A tritium-labelled form of aluminium acetylglycyrrhetate has been synthesised by
      catalytic exchange with tritiated water. An oral dose of aluminium [3H]
      acetylglycyrrhetate to rats was mainly excreted in the faeces (a mean of 73%). A
      mean of 4% was excreted in the urine and after five days 17% of the radioactivity
      was retained in the carcass. The amounts of non-volatile (drug-related
      radioactivity excreted in faeces and urine during five days were 65% and 3%,
      respectively, while 6% was retained in the carcass. The total amount of tritiated
      water produced was 24% of the dose. Experiments in rats with cannulated bile
      ducts indicated that much of the faecal radioactivity represented unabsorbed
      drug. 15% of an oral dose was eliminated in bile during 2 days. A minimum value
      for the extent of absorption of an oral dose was estimated as 21%. Plasma levels
      of radioactivity were very low and peak levels of drug-related radioactivity were
      reached at 30 min and represented about 0.2% of the dose in total plasma.

PMID- 1036701
TI  - [The influence of orotic acid on the learning process of rats. Short
      communication (author's transl)].
AB  - A genuine water soluble orotic acid, e.g. thiamindisulfide orotate, increases the
      learning capability and thus the so called "short-time memory" in rats.

PMID- 1036702
TI  - [Study on different kinds of animal feed for their adequateness for breeding and
      rearing beagle dogs. 1st communication: summarizing presentation of results
      (author's transl)].
AB  - Some of the current food mixtures for dogs available on the market and their
      further development were tested regarding the usage under rational and
      standardized experimental conditions. Further, it should be clarified which of
      the two separate modes of nutrition has the better effect on breeding and rearing
      of dogs. The use of a complete feed for breeding and maintaining (Altromin H) was
      compared with a special breeding feed (Zahn Z) together with a special
      maintenance feed (Zahn H). The tests were made at two places (Mannheim and
      Ingelheim) mainly on Beagle dogs. The food mixtures are described with the kind
      and quantity of the ingredients and nutrients. The results of the parameters
      measured in breeding effect, nursing period and rearing phase showed that all the
      feeds tested were nutritively satisfactory to the animals. Detailed information
      will be given in the 2nd and 3rd communications. Further investigations should be
      carried out on food consumption, food wastage, optional usage of the ingredients
      of the foodstuff and on energy balance.

PMID- 1036703
TI  - Behavioral effects of withdrawal of fluphenazine after long-term treatment.
AB  - Male Wistar rats were treated i.p. with 10-(3-[4-(2-hydroxyethyl)-1-piperazinyl]
      propyl)-2-(trifluoromethyl)-phenothiazine (fluphenazine dihydrochloride, FL,
      Mirenil) in a dose of 1 mg/kg for 28 weeks, or in a dose of 5 mg/kg for 21 weeks,
      beginning from the 6th day of life. Withdrawal of the drug caused an abstinence
      syndrome in the form of increased locomotor and exploratory activity and
      increased irritability of the animals. Behavioral observation during the period
      of drug administration indicated the development of tolerance to behavioral
      effects of FL. Male and female Wistar rats from mothers treated i.p. with 1 mg/kg
      of FL during pregnancy and lactation period were treated for 32 weeks with 1
      mg/kg of FL beginning from the 8th day of life. In males, during the period of
      withdrawal as well as during renewed treatment, an increase in locomotor and
      exploratory activity was observed. The behavior of female rats during the
      withdrawal period was similar to that of control animals. The abstinence syndrome
      observed after withdrawal of FL is modified by the time of life at which
      treatment was started and by the sex of the animals.

PMID- 1036704
TI  - Absorption and excretion of 4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370)
      in man and dog.
AB  - The blood levels and excretion of radioactivity administered as 14C- or 3H-4
      prenyl-1,2-diphenyl-3,5-pyrazolidinedione (DA 2370) have been studied after oral
      administration to dogs and man. After a single dose of 14C- or 3H-DA 2370 (10
      mg/kg) to dogs the daily loss of radioactivity in urine and faeces fell to less
      than 1% of the dose in 4 days and the plasma levels showed a biexponential decay
      with mean half-lives of 3.7 and 62 h. When a single 200 mg dose of 3H-DA 2370 was
      administered to human subjects maximum urinary excretion of radioactivity
      occurred during day 2 with 4% of the total during day 5. Maximum faecal excretion
      was on day 2-3 with 0.5% of the dose on day 7. The plasma half-life was 32.5 h. A
      similar dose three times a day for 3 days had a half-life of 39 h when dosing
      ceased; radioactivity in the urine and faeces was 2% and 2.5% of the dose,
      respectively, 4 days later.

PMID- 1036705
TI  - [Critical survey on liver microsome test, a system for detecting point mutations
      (author's transl)].
AB  - The host-mediated assay systems and the liver microsome test are compared
      considering carefully the advantages and disadvantages of the different systems
      regarding practice. The essay includes methodical problems as well as relevant
      questions for humans.

PMID- 1036706
TI  - [Kinetics of ampicillin, oxacillin and carbenicillin after a short intravenous
      infusion in man].
AB  - Within 5 min 5 g of ampicillin, oxacillin and carbenicillin, respectively, were
      administered i.v. to patients with normal kidney function. Plasma levels of the
      antibiotic activity were measured up to 6 h following the injection. Urine was
      collected at intervals up to 8 h and the cumulative urinary excretion calculated.
      Furtheron, biologic half-life, volumes of distribution, total and renal clearance
      and area under the serum level curve have been assessed for the one- and the two
      compartment model. For this model the amounts of drug in central and peripheral
      compartments were simulated. The statistical evaluation resulted in a highly
      significantly better fit when the data were analyzed according to the two
      compartment model. Despite of these differences the physiological consequences of
      using the parameters of the one-compartment model were not significantly
      different.

PMID- 1036707
TI  - [Studies on the metabolism of l-asparaginic acid (author's transl)].
AB  - After infusion of DL-asparaginic acid (Inzolen) during operation the
      pharmacokinetics of L-aspartic acid were followed by means of enzymatic
      determinations in serum and urine samples. The level of L-aspartic acid in the
      serum increases during the infusion of 250 ml of Inzolen-Infusion (18.54 g DL
      aspartic acid) from an original value of 2 mg/l to a maximal value of 156 mg/l,
      reached at the end of the infusion. Two hours after the termination of infusion,
      the aspartic acid level returns almost to its original value. Only 20% of the
      infused L-aspartic acid is excreted unmetabolized.

PMID- 1036708
TI  - [Bioavailability and pharmacokinetics of 14C-cyproterone acetate after
      administration as a 50-mg tablet (author's transl)].
AB  - Four male volunteers were each given a 50 mg oral dose of methylene-14C-labelled
      cyproterone acetate in a formulation largely identical to the commercial
      preparation Androcur Tablets. A further 3 volunteers were each given 10 mg of the
      14C-labelled compound by intramuscular injection. Plasma samples were obtained
      and urine and faeces collected quantitatively from each volunteer up to 10 days
      post administration. 1. Absorption of the 50 mg of cyproterone acetate
      administered in the form of Androcur Tablets was largely complete. 2. The maximal
      plasma level of 400 +/- 40 ng cyproterone acetate equivalents/ml of plasma,
      calculated from the 14C activity, was found 3,8 +/- 0,5 hours after oral
      administration. By 10 hours post administration the plasma level had declined
      with a half-life of 7,9 +/- 2,5 hours (distribution and elimination). The
      fictitious distribution volume assignable to this process amounted to 140 +/- 40%
      of body weight. Plasma 14C-activity then decreased with a half-life of 1,8 +/-
      0,2 days, which was consistent with elimination. 3. The labelled substance was
      almost completely extractable from plasma and could be separated by
      chromatography into 2 fractions of about equal size: cyproterone acetate and one
      metabolite. 4. Orally administered cyproterone acetate was eliminated with a half
      life of 1,6 +/- 0,1 days. By 10 days post administration 33 +/- 6% of the dose
      had been detected in urine and 60 +/- 8% in faeces. Up to this time total
      elimination amounted to 93 +/- 5% of the dose. 5. After intramuscular injection
      of 10 mg of cyproterone acetate the half-life for absorption from the muscular
      depot was 7,0 +/- 0,2 hours. Between 2 and 10 days post administration there was
      a uniform decrease in plasma level and urinary elimination with half-life of 2,3
      +/- 0,1 days and 2,1 +/- 0,2 days respectively. By the end of the trial 34 +/- 5%
      of the dose had been eliminated with urine and 57 +/- 6% with faeces.

PMID- 1036709
TI  - [The influence of a therapy with vasodilating agents on the sleep EEG of patients
      with cerebral circulatory disturbances. Results of a double blind study (author's
      transl)].
AB  - In 30 patients (24 men, 6 women) aged from 30-74 years and suffering from
      ischemic lesions in the cerebral hemispheres all-night EEG recordings before and
      after a 3 weeks' treatment with vasodilating drugs were carried out. At the same
      time the development of the clinico-neurological and psychoorganic
      symptomatology, also using test psychological methods, were studied. The drugs-
      10 patients received 50 mg raubasin, 6 patients 500 mg bencyclan and the others a
      salt solution--were administered i.v. Under the treatment no change in the
      primary sleep EEG findings could be observed, whereas there was an improvement of
      the clinico-neurological and psychoorganic symptomatology in the drug as well as
      in the placebo group. The lack of improvement in mood and state of well-being is
      discussed in its relationship to the sleep behaviour.

PMID- 1036710
TI  - [On the effect of colloid sulphur addition to shampoos on the pileous skin of the
      head (author's transl)].
AB  - A group of 16 male test persons was subjected to hair washes with a standard
      tenside solution over a period of 4 weeks at one-weekly intervals. 1.25%
      colloidal sulphur were added to the solution for the 3rd hair wash. From the 2nd
      week onwards quantitative lipid determinations were carried out on the 2nd and
      5th day after washing. The samples from the 5th day were also analysed by thin
      layer chromatography. We could not demonstrate any influence on the amount of
      lipid. There was, however, after the addition of sulphur a significant reduction
      in the free fatty acids to the advantage of the triglycerides. The addition of
      sulphur, therefore, brings about a decrease in the bacterial lipolysis of the
      triglycerides on the hair of the head. Apart from this, a significant increase in
      the free cholesterol and a significant decrease in the wax and cholesterol esters
      could be demonstrated after the application of sulphur. This could be possibly an
      expresion of the keratolytic effect of the sulphur.

PMID- 1036711
TI  - [Pharmacology of "essential" phospholipids (author's transl)].
AB  - In an extensive pharmacological screening of "essential" phospholipids (EPL)
      antilipemic, hepatoprotective, broncholytic, as well as slight choleretic effects
      were found and the substance decreased capillary permeability. There was
      practically no influence on other functions or systems including the vegetative
      system (heart, circulation, respiration).

PMID- 1036712
TI  - [The anti-hyperlipemic and anti-atherogenic effect of "essential" phospholipids:
      a pharmacologic trial].
AB  - To prove antilipemic and antiatherogenic effectiveness several animal species
      were given "essential" phospholipids (EPL) during different experimental
      procedures. The following actions were studied: 1. Effect of EPL-substance after
      prophylactic and therapeutic oral administration (dosage: 50, 150, 450 mg/kg
      bodyweight daily) in rats with acute and subacute hypelipemia induced by triton.
      2. Effect of EPL-substance after prophylactic and therapeutic oral administration
      (dosage: 50, 150, 450, 1800 mg/kg bodyweight daily) in rats with dietetic
      hypercholesterolemia. 3. Effect of EPL-substance after daily oral administration
      (dosage: 50, 150, 450 mg/kg bodyweight) on the development of coronary and aortic
      atherosclerosis and various biochemical parameters in cholesterol-fed cockerels.
      4. Effect of EPL-substance after dialy oral administration (dosage: 50, 150, 450
      mg/kg bodyweight) on subacute triton-hyperlipemia in mini pigs. Triton
      administration causes a greater or smaller increase in all parameters of the
      lipid metabolism measured. EPL treatment decreases these parameters during
      therapeutic and prophylactic administration in some cases even reaching normal
      values. The effect was clearly dose-dependent. EPL inhibit the increase in total
      lipids in dietetic hypercholesterolemia during therapeutic as well as during
      prophylactic administration. The effect was clearly dose-dependent in all doses,
      being statistically significant at the highest dosage level. In cockerels EPL
      were effective at all dose levels in counteracting the development of coronary
      atherosclerosis while the effect in atherosclerosis of aorta was less distinct.
      Except for non-esterified fatty acids, EPL reduced all biochemical parameters
      measured.

PMID- 1036713
TI  - [Animal experimental studies on the pharmacokinetics of "essential" phospholipids
      (EPL)].
AB  - The pharmacokinetics of orally applied "essential" phospholipids (EPL) (i.e.
      polyenyl phosphatidyl choline) was investigated in conscious and in anesthetized
      rats with the aid of radioactively labelled dilinolyl phosphatidylcholines (3H
      and 14C.). Absorption, distribution and metabolism of EPL were studied using
      autoradiography and by measuring the distribution of the abosrbed radioactivity
      in lymph, blood and internal organs, and by determining excretion and expiration.

PMID- 1036714
TI  - Chrysotile-induced asbestosis: changes in the free cell population, pulmonary
      surfactant and whole lung tissue of rats.
AB  - Rats inhaling chrysotile asbestos contracted asbestosis and fibrosis of the
      lungs. Studies of biochemical and morphological changes (between normal and
      treated animals) show that chrysotile induces an increase in the lung free cell
      population and pulmonary surfactant levels. Lysosomal enzyme levels are elevated
      in both the whole lung and free cell population and there are considerable
      changes in macrophage morphology. It is suggested that the primary response of
      the lung to chrysotile is an increase in surfactant production coupled with an
      increase in free cell numbers, in order to prevent the cytotoxic effect of the
      dust.

PMID- 1036715
TI  - Facilitated transport of di- and trinitrophenolate ions across lipid membranes by
      valinomycin and nonactin.
AB  - The conductance of black lipid membranes in the presence of 2,4,6-trinitrophenol
      (or 2,4-dinitrophenol) is considerably enhanced, if the cation carriers
      valinomycin, enniatin B or nonactin are added. The effect is, however, largely
      independent of the cation concentration and is identical for the cations Li+, Na+
      and Ba2+. This finding, as well as the sign and magnitude of the diffusion
      potential in the presence of a gradient of picrate are consistent with the
      assumption that the transport of picrate anions is facilitated by the above
      mentioned macrocyclic compounds, but that cations are not directly involved. A
      model is suggested which, based on the generation of mobile defect structures by
      the incorporation of large molecules, allows one to explain facilitated transport
      without the assumption of stable chemical bonds between a carrier and its
      transported substrate. If K+ is present in the aqueous phase, the conductance is
      largely determined by the permeation of the cation complexes of valinomycin and
      nonactin. The conductance is, however, increases by adsorption of picrate anions
      to the membrane surface. The negative surface potential generated by the
      adsorption layer seems to be responsible for the saturation of the conductance at
      high picrate concentrations in the absence of valinomycin and nonactin.

PMID- 1036716
TI  - Combined modality treatment of American Burkitt's lymphoma.
AB  - Fifteen American patients with Burkitt's lymphoma were treated in a clinical
      trial employing chemotherapy, radiotherapy, and immunotherapy. Two patients died
      during induction, and 13 achieved complete responses. Eight patients relapsed at
      a median of 11 weeks from initial treatment, and seven of these have died. The
      remaining patient has enjoyed a prolonged third remission following intensive
      chemotherapy and bone marrow autograft. Five patients remain in their first
      remission in excess of 1 year. The major therapeutic goal in the management of
      Burkitt's lymphoma is the prevention of relapse; the identification of risk
      factors and various strategies to achieve this goal are discussed.

PMID- 1036717
TI  - Luekemic infiltration of the prostate: a case study and clinicopathological
      review.
AB  - A case of leukemic infiltration of the prostate occurring with acute retention of
      urine is reported. Examination of the blood showed chronic lymphocytic leukaemia
      (CLL). The number of reported cases of leukemic infiltration of the prostate is
      updated and a review of the literature on the subject is presented.

PMID- 1036718
TI  - The relationship between the ionic composition of the environment and the
      secretory activity of the endocrine cell types of Stannius corpuscles in the
      teleost Gasterosteus aculeatus.
AB  - The corpuscles of Stannius of threespined sticklebacks contain two glandular cell
      types of presumed endocrine nature. To elucidate the function of both cell types
      the secretory activity of the cells was studied in fully adapted seawater and
      freshwater fishes and in specimens transferred from sea water to fresh water or
      adapted to media of various ionic composition. The secretory activity was
      established, in tissue sections and freeze-etch replicas, by estimating the
      volume of the nuclei, the density of the nuclear pores, and the frequency of
      exocytotic phenomena. The type-1 cells, ultrastructurally comparable to the
      predominant or only cell type described in many other teleosts, are more active
      in sea water than in fresh water. The activity of the type-2 cells, whose
      ultrastructural appearance is known only for salmonids and eels, is higher in
      fresh water. Transfer of seawater fishes to fresh water results in reduction of
      type-1 cells and activation of type-2 cells. The factors responsible for these
      changes were analyzed by exposure of fishes to solutions of various salts in
      fresh water and to artificial sea water with a reduced content of one of its
      components. The high activity of type-1 cells in sea water proved to be related
      to the high calcium content of this medium. These cells probably produce a
      substance comparable to hypocalcin, the endocrine factor isolated from the
      Stannius corpuscles of some other teleost species. The high activity of type-2
      cells in fresh water appeared to be connected with the low sodium and potassium
      levels of this medium. Type-2 cells possibly produce a hitherto unknown hormone
      involved in the control of sodium and/or potassium metabolism.

PMID- 1036719
TI  - Sexually transmitted disease in Rhodesia.

PMID- 1036720
TI  - The value of the foam stability test.

PMID- 1036721
TI  - [Thoughts on dermatovenerology training].

PMID- 1036722
TI  - Cytological factors and their predictive role in comparative radiosensitivity: a
      general summary.
AB  - Various cytological factors, including interphase chromosome volume (ICV),
      nuclear volume (NV), cell volume, DNA content per nucleus and per chromosome,
      have been reviewed to determine their usefulness as indices to predict
      radiosensitivity. Fourteen topics are discussed. They are: a historical
      development of the concept of using karyotypic features to estimate
      radiosensitivity; interrelationships between cellular parameters; relationship of
      the karyotype to the duration of mitosis and meiosis; relationships between
      chronic and acute irradiation and ICV using several radiobiological end points
      for woody and herbaceous species; correlations between dose and cellular
      parameters ftween chromosome aberrations and cellular characteristics after
      chronic irradiation; polyploidy and plant radiosensitivity; radiation-induced
      petal mutations in plants and their relationship to cellular parameters;
      correlations between mean survival time facter irradiation and cellular
      parameters in amphibians and higher plants; correlations between radiobiological
      end points and cellular parameters after whole-body irradiation in amphibians.
      insects and mammals; correlations between radiosensitivity and cellular
      parameters in diverse single-cell organisms; correlations between radiobiological
      end points and cellular parameters in higher plants irradiated with neutrons and
      the value of cell parameters to estimate relative biological effectiveness (RBE);
      and energy absorption and trends in radiosensitivity among species and
      radiobiological end points. It is concluded that ICV is usually the most useful
      parameter for predicting radiosensitivity.

PMID- 1036723
TI  - Degeneration of Leydig cells in the skin of the salamander treated with
      cholinolytic drugs or surgical denervation.

PMID- 1036724
TI  - [Hydantoin derivatives and malignancies of the haemopoietic system].

PMID- 1036725
TI  - [Use of pyrogen-therapy in dermato-venerology].

PMID- 1036726
TI  - [Improved results in the elicitation of infection sources in subjects with
      venereal diseases and endangered subjects through reinterviewing].

PMID- 1036727
TI  - Changes in nucleotide metabolism of the liver and fate of [14C]orotate among
      various pyrimidines at the outset and during induction of drug-metabolizing
      enzymes and hepatomegaly.

PMID- 1036728
TI  - Studies on the relationship between induction of drug-metabolizing enzymes, liver
      enlargement and ascorbic acid excretion in rodents.

PMID- 1036729
TI  - [Study on contraceptive mechanism of copper and plastic intrauterine devices in
      rats (author's transl)].

PMID- 1036730
TI  - Evidence that the fertilization envelope blocks sperm entry in eggs of Xenopus
      laevis: interaction of sperm with isolated envelopes.

PMID- 1036731
TI  - Lack of effect of acute prolactin suppression on renal water sodium and potassium
      excretion during sleep.
AB  - The possible role of endogenous prolactin (hPRL) in the regulation of renal
      water, Na and K excretion during sleep was tested in a group of 10 healthy female
      volunteers. Plasma hPRL and total urinary Na and K excretion were measured at 2-
      and 4-hourly intervals, respectively, in the control period and after prolactin
      inhibition with bromocriptin. Despite adequate prolactin suppression, no
      significant changes were observed in the nyctohemeral excretion rhythms of water,
      Na and K, suggesting that endogenous prolactin is not instrumental in the control
      of these parameters.

PMID- 1036732
TI  - Urinary excretion of drugs in chronic renal impairment with respect to changes
      their tubular handling by residual nephrons.
AB  - Decrease of the relative value of the renal clearance (the ratio between the
      value observed and the normal value) of a drug may be slower than the decrease of
      the relative value of the glomerular filtration rate. A slower decrease of drug
      renal clearance may be due to an increase in its effective secretion or a
      decrease in its effective reabsorption by residual nephrons. The mechanisms
      underlying these changes still remain obscure. One of the factors is assumed to
      be sodium osmotic diuresis in residual nephrons (associated with functional
      adaptation).

PMID- 1036733
TI  - Biotransformation of ioglycamic acid, iodoxamic acid and iotroxic acid in man.
AB  - The biotransformation of the 131I-labeled cholegraphic media ioglycamic acid,
      iodoxamic acid and iotroxic acid in man is investigated. Plasma, urine and
      fistular bile were analyzed for unchanged and metabolized constituents of the
      administered substances using thin layer chromatography. No metabolites were
      found in plasma, but up to two were found in urine in addition to unchanged
      contrast media (a total of 50% of the total elimination in 24 hr. urine). A
      metabolite was only found in the fistular bile after the injection of iotroxic
      acid.

PMID- 1036734
TI  - Effect of centrally applied monoamines on thermoregulation in the pigeon.

PMID- 1036735
TI  - [ Follow-up study of 44 surgically and conservatively treated tibiae head
      fractures].

PMID- 1036736
TI  - Articulation in early childhood autism.
AB  - Using a standardized articulation test, comparisons were made between the
      articulation of autistic children and (1) a group of predominantly subnormal
      language matched controls; (2) developmental receptive dysphasic controls. The
      autistic children's articulation was significantly superior to that of both
      control groups. The findings are discussed in relation to differences in the
      pattern of language impairment in the three groups.

PMID- 1036737
TI  - Phonological investigation of verbal autistic and mentally retarded subjects.
AB  - A review of the pertinent literature indicates that autistic children are likely
      to show normal but delayed development of speech sounds. In contrast, atypical
      phonological development is suggested by experiments demonstrating that autistic
      subjects are deficient in their ability to extract the components of structured
      auditory input. A systematic investigation of the speech sound systems of verbal
      autistic and mentally retarded children reveals a delay in phoneme acquisition,
      as well as a relative uniformity of error types in both groups. The autistic
      subjects, however, differ significantly from the mentally retarded in the
      phonemic substitutions which they make. Autistic subjects are also characterized
      by a high correlation between frequency of phonological errors and level of
      overall language development. The findings are interpreted as supporting the
      hypothesis that the autistic group shows a more global delay in language
      development.

PMID- 1036738
TI  - Reassessment of elevated serotonin levels in blood platelets in early infantile
      autism.
AB  - Blood platelet serotonin content was measured in 30 children with early infantile
      autism, as defined by Kanner, 30 age-matched normal subjects, and 45 children
      with various neurological and psychiatric disorders. Serotonin content in the
      autistic group was 980 +/- 357 ng/mg platelet protein (mean +/- standard
      deviation), a value significantly higher than that for normal children, 807 +/-
      202 ng/mg (p less than .025). Autistic children under school age had higher
      platelet serotonin concentrations than other older autistic individuals. There
      was little correlation between age and serotonin levels in the normal children.
      Elevated serotonin was also seen in some of the non-autistic pathological group,
      who were disturbed and hyperactive. Elevated serotonin levels are not necessarily
      a specific biochemical finding for autistic children, but seem to be due to their
      behavioral distinction.

PMID- 1036739
TI  - Neuropathologic aspects of psychosis in children.
AB  - On the basis of a search of the literature and extensive inquiries to clinicians,
      this paper catalogues those cases that contain any information concerning
      possible neuropathologic changes in cases of childhood autism or psychosis. In
      all, 33 cases were identified. Twenty-nine cases are from the literature; six of
      these are sibling pairs. Four cases were folnd by inquiry and have not been
      reported heretofore. Because of limitations in both the clinical and
      neuropathologic data in most of the case reports, the paper serves primarily as a
      source of reference to the 33 cases identified. The information that is available
      is presented along with some tentative suggestions for further research.

PMID- 1036740
TI  - Platelet uptake and efflux of serotonin in subtypes of psychotic children.
AB  - The only finding of a metabolic defect in psychotic children which has been
      replicated in a blind study is the discovery of an elevated efflux of serotonin
      from the platelets of children with early infantile autism (Boullin, Coleman, &
      O'Brien, 1970; Boullin, Coleman, O'Brien, & Rimland, 1971). The reported failure
      of Yuwiler, Ritvo, Geller, Glousman, Schneiderman, and Matsuno (1975) to
      replicate the Boullin et al. findings is attributable to differences in the
      method of selecting subjects. The Boullin et al. studies found that only children
      with classical infantile autism, as diagnosed by the Rimland E-2 check list,
      manifested the metabolic error. Since only 10% of psychotic children score in the
      autistic range on the check list, and since all children in the Yuwiler et al.
      study displayed the syndrome of "perceptual inconstancy," a syndrome inconsistent
      with "insistence on the preservation of sameness," an integral part of the
      syndrome of early infantile autism as scored on the E-2 check list, the failure
      of Yuwiler et al. to find elevated efflux in their sample was to be expected.

PMID- 1036741
TI  - Vitamin B12 and potential fertility in male lactovegetarians.

PMID- 1036742
TI  - Hashimoto's thyroiditis presenting as a solitary functioning thyroid nodule.
AB  - A case of hypothyroidism is described in a young woman who on thyroid scan had a
      discrete functioning "nodule" with homogeneous radioactive iodine uptake, and
      surrounded by atrophic non-functioning thyroid tissue. Antithyroglobulin
      antibodies were not demonstrable, but anti-microsomal antibodies were positive at
      a titer of 1:25,600. Histologically, the "nodule" represented Hashimoto's
      thyroiditis with more extensive destruction of the remaining gland. Although it
      is unusual, Hashimoto's disease should be considered in the differential
      diagnosis of functioning thyroid nodules, and both anti-thyroglobulin and anti
      microsomal antibodies should be obtained in such circumstances.

PMID- 1036743
TI  - Ovarian refractoriness to gonadotropins in cases of inappropriate lactation:
      restoration of ovarian function with bromocryptine.
AB  - In ten patients with amenorrhea-galactorrhea who had hyperprolactinemia,
      ovulation could not be induced clomiphene citrate or exogenous gonadotropins.
      Treatment with bromocryptine in eight of these patients resulted in suppression
      of PRL in all, cessation of galactorrhea and ovulation in seven and conception in
      five.

PMID- 1036744
TI  - The in vitro suppression of lectin induced 3H-thymidine incorporation into DNA of
      peripheral blood lymphocytes after the addition of propylthiouracil.
AB  - A possible in vitro immunosuppressive role of propylthiouracil (PTU) was
      investigated by culturing peripheral blood lymphocytes (PBL) from normal subjects
      with plant lectins in the presence of PTU added at the onset of culture or near
      the time of peak cell division. When added at the onset of culture PTU caused a
      dose-related suppression of lectin stimulated 3H-thymidine uptake with an average
      of approximately 50% suppression at a PTU concentration of 100 mug/ml. When added
      at the time of peak cell division however, marked suppression was produced by 10
      mug/ml of PTU. Prolonged remissions in patients with Graves' disease treated with
      PTU, and possibly other anti-thyroid drugs, may thus be due to an
      immunosuppressive role of the drug rather than the natural evolution of the
      disease.

PMID- 1036745
TI  - Soil persistence and aquatic bioaccumulation potential of hexachlorobenzene
      (HCB).

PMID- 1036746
TI  - Diphenadione residues in milk of cattle.

PMID- 1036747
TI  - Antepartum prevention of respiratory distress syndrome (hyaline membrane
      disease).

PMID- 1036748
TI  - Electron microscope assessment of fertilization of rabbit ova treated with
      concanavalin A and wheat germ agglutinin.
AB  - Zonaless rabbit ova, exposed to Concanavalin A or Wheat Germ Agglutinin, then to
      uterine capacitated sperm produce pronuclear, 2 and 4 stage embryos that are
      indistinguishable from controls. Absence of cortical granules indicates that the
      ova were fertilized and not merely activated. Survival of lectin-bearing
      receptors during the period necessary for fertilization was evaluated in ova
      marked with ferritin-conjugated lectin.

PMID- 1036749
TI  - Enhancement of haemolysis by Newcastle disease virus (NDV) after pre-treatment
      with heterophile antibody and complement.
AB  - Pre-treatment of Newcastle disease virus (NDV) with fresh human plasma enhances
      its haemolytic (HL) capacity by several factors. The effect is due to complement
      activation by the heterophile anti-chick antibody present in human plasma. All
      the adult human plasmas tested were effective, also 91/100 human cord blood sera.
      The antibody was mainly of the IgM class. The enhanced HL was due to integration
      and transference of the complement 'holed' virus envelope membrane and subsequent
      leakage of haemoglobin. High concentration of activated complement destroys the
      integrity of the virus enevelope. Treatment of chick erythrocytes and fibroblasts
      with human plasma also produced lysis of the cells.

PMID- 1036750
TI  - The recognition and management of blastomycosis.

PMID- 1036751
TI  - [A case of primary lymphosarcoma of the lung].

PMID- 1036752
TI  - [Radioisotope methods of control of the effectiveness of treatment of diffuse
      toxic goiter with mercazolyl].

PMID- 1036753
TI  - [Therapy of traumatic and inflammatory-degenerative diseases with Rheumatol
      dragee in surgical ambulatory care].

PMID- 1036754
TI  - Spermatozoal migration and lymphatics: a hypothesis.
AB  - The exact mechanism of sperm migration is still unknown. Lymphatics may act as
      transporting channels for the migration of sperms. The relevant literature is
      reviewed and it is suggested that myometrial contractions may allow the
      lymphatics of the uterus to take up the sperms and pump them actively towards the
      uterine tubes, where they are pumped again by tubal contractions towards their
      destination at the end of the tube where they fertilize the ovum.

PMID- 1036755
TI  - Pregnancy following bromocryptine therapy for the amenorrhoea-galactorrhoea
      syndrome due to a pituitary tumour.
AB  - A woman developed amenorrhoea and galactorrhoea after partial removal of a
      pituitary tumor during pregnancy. Hyperprolactinaemia was supressed by therapy
      with bromocryptine (CB 154, Sandoz) resulting in cessation of galactorrhoea in
      two months, spontaneous menstruation after eight months, and pregnancy after
      twelve months.

PMID- 1036756
TI  - [Gas-chromatographic determination of plasma free amino acids as an evaluation of
      the protein nutrition status of the infant].

PMID- 1036757
TI  - [Relation between citicoline and pulmonary surfactant. Recent acquisitions in the
      treatment of respiratory syndromes of the newborn].

PMID- 1036758
TI  - Choosing an architect.

PMID- 1036759
TI  - Mechanism of action of benzilylcholine mustard at the muscarinic receptor.

PMID- 1036760
TI  - The reaction of Cytembena with cellular thiol compounds.
AB  - Cytembena has been shown to undergo a rapid addition reaction with a number of
      thiol compounds, including glutathione and cysteine, resulting in alkylation of
      the sulphur. Administration of Cytembena to Yoshida sarcoma cells and to L1210
      leukemia cells resulted in a loss of titratable thiol groups within the cells,
      though the loss of thiol groups caused by pharmacologically active doses of the
      drug was not sufficient to account, in itself, for the observed toxicity. The
      addition product of Cytembena and glutathione was isolated and tested for
      cytotoxicity; it was much less effective than free Cytembena. It is concluded
      that this reaction acts as a route of detoxification of Cytembena.

PMID- 1036761
TI  - Effects of amphetamine isomers and CNS catecholaminergic blockers on seizures in
      mice.

PMID- 1036762
TI  - Sequelae of head and neck positions on auditory performance.
AB  - Stapedius reflex level, slow auditory evoked potential (AEP), and hearing
      threshold level of 18 normal adult probands (11 female, 7 male) as well as of 14
      normal hearing cerebral palsied children between 4 and 12 years of age (5 female,
      9 males)--were determined in different postures which correspond to the influence
      of tonic reflex activities in supine and prone, and in the so-called "reflex
      inhibiting pattern" (Bobath) and in a symmetrical relaxed position of neck, trunk
      and extremities in supine (the last one could only be maintained by the normal
      volunteers). Influence of the postures was small but significant for all
      parameters in the volunteers group as well as for AEP in the patients group. In
      the latter group the influence of tonic reflex activities on auditory evoked
      potential was independent from their strength. The strength of tonic reflex
      activity had been graded from 1-5 as judged from clinical impression by
      observation and palpation.

PMID- 1036763
TI  - Bobath-therapy, tonic reflex--activities and processing of acoustic stimuli.
AB  - The influence of tonic reflex activities on the slow auditory evoked potential
      (AEP) as well as the influence of Bobath's reflex inhibiting patterns (r.i.p.) in
      a group of 14 cerebral palsied children is compared under the same conditions
      with simulated tonic reflex patterns in 18 adult normal volunteers and 15
      cerebral palsied children. In the adult volunteers group the effect of a relaxed
      symmetrical position of neck, trunk, and extremities in supine on the AEP is also
      evaluated. There are none but age specific differences in the latence of AEP
      between both groups but clear cut differences in the amplitudes and in the
      specific effect of r.i.p. in both groups.

PMID- 1036764
TI  - Muscle activity and postural behaviour in newborn infants. A polymyographic
      study.
AB  - In a group of 9 healthy newborns, spontaneous activity of different muscles was
      studied for 6 or 8 hours by means of surface electromyography on the 5th or 6th
      day of life. According to the local nursing routine the infants were placed in
      alternating left and right side positions. Averaged EMG activities were analysed
      with respect to behavioural states and observed postural behaviour. An improved
      recording technique and the logarithmic presentation of averaged EMG activities
      allowed the study of characteristics of tonic activity in state 1. The chin
      muscles showed the most specific EMG pattern in state 1. Chin muscle quiescence
      was observed during only 15% of that state. Lack of tonic activity was observed
      more in the beginning than at the end, but never in the middle of state 1. By
      visual analysis of 41 patterns of averaged EMG activities from the chin muscle it
      was found that increases of tonic activity only happen stepwise following
      concomitant phasic activities. Relaxation of tonic activity is either asymptotic
      or abrupt or by steps. The latter two are especially characteristic for the
      transition to state 2. Long periods of sustained tonic activity and low motility
      were characteristic for a long lasting state 1. The interval between the
      beginning of state 1 and the first increase of tonic activity varied more than
      the interval between the end of state 1 and the final drop of tonic activity back
      to the noise level. Other muscles showed less tonic activity in state 1: the neck
      area (sterncleidomastoid muscle 48% of state 1 time, trapezius m. 32%) was
      followed by the muscles of the forearm (extensor carpi m. 18%, flexor carpi m.
      16%). These muscles also lead the rank order of the modulation of tonic activity.
      Tonic activity sustained for more than 30 sec. was not observed in state 2,
      except during transitions. In state 2 as in state 1 the muscles from chin, neck
      and upper extremities were more active than the muscles from the lower
      extremities. Durations of activities ranged from 28% (chin) to 13% (ant.
      tibialis) of state 2 time. No dominance of flexor muscles, which might account
      for the observed flexed posture, was found. Systematically changed side positions
      during the recording had no consistent effect on either motility or presence of
      tonic activity when corresponding muscles from the upper- and the lower-lying
      body side were compared during state 1. Likewise in state 2 no consistent effect
      on the total duration of phasic activity was observed. The results are discussed
      in relation to other known state dependent motor phenomena. It is suggested that
      sustained tonic activity results from an increased gain of the gamma-loop which
      may also contribute to the regularity of respiration. Differences between muscles
      probably reflect maturational and functional differences.

PMID- 1036765
TI  - Communicating hydrocephalus causing aqueductal stenosis.
AB  - The cited evidence establishes that the pathogenetic sequence of generalized
      communicating hydrocephalus followed by various degrees of aqueductal stenosis
      occurs in many mammalian species. The aqueductal stenosis is caused by
      compression of the midbrain by the expanding cerebral hemisphere. Therefore the
      sharp separation of communicating and non-communicating hydrocephalus is no
      longer tenable.

PMID- 1036766
TI  - Benign hereditary non-progressive chorea of early onset. Clinical genetics of the
      syndrome and report of a new family.
AB  - The syndrome of benign non-progressive chorea (of early onset) is described in
      three brothers and some of their relatives. Clinical genetic study of the family
      showed an autosomal dominant mode of inheritance and suggested presence of the
      gene in both sides of the family. Thus, the propositi might be homozygous for the
      dominant gene (suggested by increased clinical manifestations as compared with
      other affected members on both sides of the family) which shows relatively high
      penetrance and variable expressivity. The phenotypic spectrum of the syndrome is
      differentiated from similar observations in the literature, and genetic
      implications are discussed. The condition is differentiated from hereditary
      essential tremor and from paramyoclonus multiplex.

PMID- 1036767
TI  - Propanolol treatment of infantile polymyoclonia.
AB  - Two infants with the classical involuntary movements of polymyoclonia and
      opsoclonus were treated with propanolol in a dosage of 2 mg/kg/24 hr. There was a
      marked improvement in the abnormal movements in both children. No side effects of
      treatment were encountered.

PMID- 1036768
TI  - [Treatment of intractable pain by barbotage of the cerebrospinal fluid].

PMID- 1036769
TI  - [2-Br-alpha-ergocryptine in the treatment of amenorrhea-galactorrhea syndromes
      and in inhibition of puerperal lactation. Effect on secretion of prolactin and
      pituitary gonadotropin].

PMID- 1036770
TI  - [Pathogenesis of spontaneous epiretinal fibroplasia].

PMID- 1036771
TI  - [5,000 mammography--results and analysis (author's transl)].
AB  - Mammography, well performed, is the best method for the differential diagnosis of
      breast diseases. It is essential for the detection of clinical occult cancer (in
      some cases thermography can do the same). The earlier breast cancer is diagnosed
      the lesser is the chance of lymphnode involvement. Therefore women aged over 40
      years and belonging to a so-called riskgroup (carcinoma in the family, earlier
      breast diseases, mastopathies, breast cancer of the other breast etc.) should
      perform mammography once a year. 90% of the breast cancer patients are over 40
      years. In higher ages that mammographic diagnosis is more accurate. Considering
      the advantage of this method the effect of radiation is to be neglected. The
      experienced radiologist can obtain 90% correct diagnoses. In combination with
      thermography and needle aspiration biopsy he can improve to 95%.

PMID- 1036772
TI  - [Occurrence of retrolental fibroplasia in Poland].

PMID- 1036773
TI  - [How low fat milk became high fat milk: the story of the mushroom sausage and
      feasts for a long life].

PMID- 1036774
TI  - [Nitrogen, potassium and phosphorus balance as well as creatinine and creatine
      excretion in patients with hyperthyroid goiter treated surgically].

PMID- 1036775
TI  - [Total cortisol concentration in the surgical treatment of hyperthyroid goiter].

PMID- 1036776
TI  - [Pulmonary surfactant activity in experimental pulmonary tuberculosis].

PMID- 1036777
TI  - [Psychosocial aspects of venereal diseases. II. Family and educational status of
      patients].

PMID- 1036778
TI  - [Dermatological problems in Vietanam during the final stages of the war].

PMID- 1036779
TI  - [Psychosocial aspects of venereal diseases. III. Occupation, social status,
      financial and housing conditions of the patients].

PMID- 1036780
TI  - [Gastrojejunal lymphosarcoma in a 4-year-old boy].

PMID- 1036781
TI  - [Ventilation mechanics in the premature and the newborn. I. Statistical
      measurements of the isolated lungs].
AB  - On 31 pairs of lungs from still borns and newborns of differing stages of
      maturation and age (23rd week of gestation up to the 24th week after birth)
      statical measurements including liquid fillings were performed. On account of the
      histo-mechanical tests as well as morphological and clinical data, the group
      could be divided into normal lungs and lungs with decreased surfactant activity.
      Between the 35th week of gestation and the 5th week after birth a marked increase
      in pulmonary maturation with unproportional changes of the histomechanical values
      could be demonstrated. In lungs with decreased surfactant activity the influence
      of life span upon the mechanical properties of pulmonary tissue could be shown.
      The high surface tension decreases, presumably on account of surfactant
      synthesis, while the values of tissue elasticity decrease as a result of
      overstretching.

PMID- 1036782
TI  - [Chromatographic analysis of water-soluble vitamins. I- Chromatographic behaviour
      of water-soluble vitamins on Aminex resins (author's transl)].
AB  - The most important water-soluble vitamins are quantitatively determined by high
      pressure chromatography using porous ion exchange resins. Thiamine and
      Riboflavine are separated by a cation exchange resin Aminex A5 using 0.3 M KCI in
      0.1 M potassium phosphate pH 8.0 buffer as mobile phase; pyridoxamine, pyridoxol,
      pirydoxal and nicotinamide are successfully chromatographated on the same type of
      cationic resin using a linear gradient both of pH and ionic strength as mobile
      phase. Anionic vitamins like L-Ascorbic Acid and Nicotinic Acid are separated on
      Aminex A14 at acidic values of pH, using isocratic conditions of the ionic
      modifier. Under the described experimental conditions, the reproducibility of VR,
      RS and peak area are of 2.5% and 3% respectively. The sensitivity relative to the
      vitamins tested ranges from 100 to 250 ng.

PMID- 1036783
TI  - [The sterolic fraction of virgin olive oil and its and its analytical
      significance].
AB  - The influence of the cultivar factor over the composition of the sterolic
      fraction of virgin olive oil has been verified by G.L.C. Such a fraction is not
      influenced by either the poor condition of the olives or the auto-oxidation
      process of oil. The use of many selective stationary phases like OV-17 in
      comparison with the SE-30 doesn't improve the analitic situation aiming at
      guarding the genuineness of the virgin oil. The analytic results confirm the
      value of the official method, even if, in the very few cases of oils with an
      insufficient level of beta-sitosteroil, blending it is necessary.

PMID- 1036784
TI  - [Studies on milk from different species. I. The content of methionine in cow,
      water buffalo and sheep caseines].
AB  - The present paper reports the content of methionine in cow, water buffalo and
      sheep casein measured according to Maugenet and Coauthors. The following values
      were obtained: 3,25% in cow; 3,15% in water buffalo; 3,16% in sheep.

PMID- 1036785
TI  - [Influence of technological processes on the extractability of phenols and
      carbohydrates from sunflower meal and related protein solubility].
AB  - A chemical method for the removal of chromogenic phenolic constituents and
      carbohydrates of the sunflower meal has been investigated. This method uses a
      nondenaturing polar solvent formed by n-butanol saturated by diluite HCl and
      allows the preparation of protein isolate off-colour free. Evaluations on the
      extractibility of phenols, carbohydrates and proteins of sunflower meals from
      different technological processes have been carried out.

PMID- 1036786
TI  - [Results of some experiences on modern techniques of vinification of red grapes].
AB  - The results of experiences carryed out at the "Istituto di Industrie Agrarie" of
      the University of Bologna in the last five years, applying the techniques of
      vinification by carbonic maceration (CM) and by heat treatment of the crushed in
      the production of Emilia-Romagna wines, are reported. In particular, the
      evolution of the main organic constituents during anaerobic conditioning of
      grapes, the possibility of applying the CM to Sangiovese, Merlot and Canina
      grapes, the different variations of the CM technique, that is, CM followed by
      information with skins, the rifermentation of wines produced by traditional
      method with 10-20% of grape juice obtained by CM, the influence of CM on aging of
      barbera wine, some laboratory tests to explain the mechanism that regulate same
      interaction phenomena during the "intracellular fermentation", are discussed. The
      results of technique of heat treatment of the crushed, in the vinification of
      Sangiovese grapes, in a pilot plant, are exposed. Finally, the effects of some
      parameters (treatment of the crushed integral or partially dripped, heating
      temperature, rest time, sulphur dioxide employ, etc.) on the chemical
      characteristics and on the organoleptic quality, are estimated.

PMID- 1036787
TI  - [Search of optimum survival conditions for lactic acid bacteria in powders
      obtained by spray drying of yoghurt].
AB  - The paper reports the results of two spray-drying tests carried out on yogurt as
      such or previously neutralized. The operating conditions of the drying operation
      were such that the temperature of the product didn't exceed 80 degrees C, and the
      residual moisture of the powder was about 10%, slightly higher than the B.E.T.
      monolayer value. The decrease of total counts was three and two decimal
      reductions respectively for the natural and neutralized product. This latter gave
      also much higher viability index as determined in a "fermenting activity" test.
      Also, the analyses, related to the quality of the protein fraction, strongly
      support the opportunity of neutralization before drying. In storage tests carried
      out during 8 months the survival data were higher at 5% relative humidity
      (corresponding to 7-8% humidity) and at 5 degrees C temperature. In all cases the
      better results were obtained from the powders of neutralized yogurt, even in
      comparison with a freeze-dried sample obtained from the natural product. The
      typical shape of the sorption isotherms of these products suggests that the
      optimum process as regard to microorganisms' survival consists in drying the
      neutralized product up to residual humidities of 8-10%, followed by storage, in
      humidity-proof containers, at temperatures of about 5 degrees C.

PMID- 1036788
TI  - [Development of a "vortex bed" drying apparatus].
AB  - Fundamental parameters in dimensioning a "vortex bed" drying apparatus are the
      pressure drop across the bed and the higher and lower limit of fluidization
      velocity. The analysis of the Navier-Stokes equations brings to the following
      functional relations between dimensionless groups: (see journal). These relations
      define the fluidization conditions in a "vortex bed" apparatus. Experimental
      tests carried out on a laboratory scale apparatus will provide us with the
      unknown constants for industrial scale extrapolation.

PMID- 1036789
TI  - [Poly-protein. I- A new process for obtaining leaf protein concentrates].
AB  - The authors have devised a new process, called POLY-PROTEIN, for obtaining leaf
      protein concentrates from alphalpha juice by precipitation with polyelectrolites.
      The use of steam is avoided and the technology is very simple, making this
      process more economical than those already employed.

PMID- 1036790
TI  - [I.M.F.: intermediate moisture foods (author's transl)].

PMID- 1036791
TI  - [Determination of chloramphenicol residues in milk by the gas chromatography
      method].

PMID- 1036792
TI  - [Treatment of Basedow's exophthalmos].

PMID- 1036793
TI  - A pathomorphic study of chronic thyroiditis.
AB  - The authors studied the pathomorphy of 364 cases of chronic thyroiditis including
      Hashimoto's thyroiditis (67 cases), Hashimoto's thyroiditis associated with
      thyroid cancer (21 cases), De Quervain's thyroiditis (10 cases), tuberculous
      thyroiditis (6 cases), and 260 cases of focal thyroiditis without manifest
      clinical symptoms appearing in 10% of euthyroid polynodular goitres. A personal
      classification of chronic thyroiditis is presented. The high incidence (24%) of
      association between thyroid cancer and the fibrous type of Hashimoto's
      thyroiditis is emphasized. A morphometric investigation showed the highest
      sclerosis percentage in De Quervalin's thyroiditis.

PMID- 1036794
TI  - [Clinical features of Cryptococcus neoformans infections].
AB  - Two cases of infection with Cryptococcus neoformans are presented. The first
      showed primary localization in the CNS, while the second occurred in connection
      with lymphoproliferative malignancy and cytotoxic chemotherapy, with the typical
      sequence of initial lung infection and secondary meningo-encepha-litis. The
      important clinical features, development and therapy of the disease are discussed
      in the light of this personal experience.

PMID- 1036795
TI  - [Fine needle biopsy of "cold" struma nodules in 4555 patients of an endemic
      goiter area. Results and clinical significance].
AB  - Over a period of 8 years, thin needle biopsies of hypofunctional,
      scintigraphically cold goiter nodules were performed in 4555 patients. 1076
      underwent surgery and cytological diagnoses were thereby histologically
      confirmed. In 715 patients with normal or degenerative cytological findings, the
      diagnosis was correct in 95.1%. On the other hand, 8 malignancies, 13 Hurthle
      cell adenomas, and 26 cases of Hashimoto's thyroiditis were misdiagnosed. The 8
      diagnostic errors in the malignancies were due to puncturing of the wrong nodule
      in 3 cases and, in 5 cases, due to highly differentiated, partially degenerated,
      follicular carcinomas. In 322 cases with suspect or malignant cytological
      findings, 129 malignancies (40%) were confirmed. In most cases, false positive
      diagnosis was due to histologically atypical adenomas, e.g. Hurthle-cell
      adenomas. Hashimoto's thryoiditis could be readily diagnosed only in the advanced
      stage. The clinical diagnosis of de Quervain's thyroiditis can be verified by
      cytological examination.

PMID- 1036796
TI  - [Microaggregates in preserved blood].
AB  - Today it is generally accepted that microaggregates contained in stored blood may
      be deleterious to the pulmonary circulation if large volumes of blood are
      transfused. These microaggregates can be eliminated from blood with the help of
      microaggregate filters. Such filters are expensive and their efficiency and
      safety has not been tested thoroughly as yet. Alternatively, the use of
      microaggregate-free blood is advocated to prevent pulmonary complications in
      massively transfused patients. Fresh blood, fresh frozen plasma and buffy-coat
      free red cell concentrates do not contain significant numbers of microaggregates
      and can be used for massive transfusion without microaggregate filtration.

PMID- 1036797
TI  - [Some biochemical aspects of the pathogenesis of tick-borne North Asian
      rickettsiosis].

PMID- 1036798
TI  - [The teratogenic action of parbendazole].

PMID- 1036799
TI  - The activation of human factor X in sodium citrate: the role of factor VII.
AB  - Human factor X was purified by several different procedures yielding products
      which had varying amounts of factor VII and factor IX. Treatment with CHCl3
      during the fractionation of the factor X removed 95% of the factor VII and factor
      IX activity and the resulting factor X activated more slowly when incubated in
      25% sodium citrate. Removal of residual factor VII by DEAE cellulose
      chromatography yielded a factor X which activated still more slowly and less
      completely. When the factor VII, removed by chromatography, was added to the
      chromatographed factor X, the ability to be activated in 25% sodium citrate was
      restored. Confirmatory evidence for the role of factor VII in this reaction was
      the inhibition of the conversion of the factor X by both DFP and SBTI.

PMID- 1036800
TI  - Bleeding in uremic patients after carbenicillin.
AB  - Hemorrhagic diathesis was observed in patients with renal insufficiency after
      carbenicillin at serum levels greater than 300 mug/ml. Normal coagulation factors
      (F. I, II, V, VII, VIII, X), normal PTT, normal platelet counts, negative ethanol
      gelation test (fibrin monomers) were found as well as a prolongation of
      thromboplastin time (Quick), thrombin time, reptilase time and thrombin coagulase
      time. Platelet function was disturbed. In addition, the plasmatic system was
      involved: inhibition of fibrinogen-fibrin conversion (Belitser assay) and
      enhanced antithrombin III activity; in vivo the latter was ascribed to a heparin
      like activity. In vitro, abnormal III was seen: however an enhanced antithrombin
      III activity in vitro was not found with carbenicillin and various penicillin
      derivatives. This study demonstrates that carbenicillin, in addition to its known
      effect on platelet function, also disturbs the plasmatic coagulation system. This
      additional effect of carbenicillin is clinically important since protamin
      chloride effectively blocks bleeding without interfering with antibacterial
      activity. Both penicillin and penicillin derivatives have been shown to interfere
      with hemostasis and to cause clinically manifest hemorrhagic diathesis (Fleming
      and Fish 1947, Lurie et al. 1970a, b, McClure et al. 1970, Yudis et al. 1972,
      Demos 1971, Waisbren et al. 1971). Carbenicillin interferes with ADP-, collagen-
      or thrombin-induced platelet aggregation and with the release reaction both in
      vivo (McClure et al. 1970, Cazenae et al. 1973) and in vitro (McClure et al.
      1970, Cazenave et al. 1973). In addition Lurie and colleagues (1970b) concluded
      that an inhibition of the conversion of fibrinogen to fibrin is involved although
      no experimental details were given. Later Brown and colleagues (1974) concluded
      that carbenicillin at usual dose levels "only affects the platelet component of
      hemostasis and has little effect on fibrin formation or other phases of
      coagulation in patients with normal renal function".

PMID- 1036801
TI  - Platelet adhesiveness and fibrinolysis after recent cerebro-vascular accidents
      and their relationship with subsequent deep venous thrombosis of the legs.
AB  - In fifteen patients with a cerebro-vascular accident resulting in an acute
      hemiplegia there was a subsequent rise in the platelet count and plasma
      fibrinogen level. There were no significant alterations in platelet adhesiveness,
      plasminogen activator, plasminogen, FR-antigen and haematocrit. Patients
      diagnosed as developing deep venous thrombosis with the 125I-fibrinogen technique
      had a significantly lower platelet adhesiveness and plasminogen level than those
      who were not.

PMID- 1036802
TI  - Microvascular haemostasis and the effect of local stimulation and inhibition of
      platelet function. An experimental study in rabbits.
AB  - The local stimulation and inhibition of haemostatic plug formation was studied by
      local infusion and superfusion of different agents - ADP, thrombin, adenosine,
      heparin, prostaglandin E1 (PGE1) and laster injury. ADP and laser injury
      shortened venular haemostatic plug formation time whereas adenosine in the
      superfusate and PGE1 prolonged it. Thrombin infusion had no effect but thrombin
      in the superfusate significantly stabilised the haemostatic plugs. It is
      suggested that ADP released from red cells is the most potent stimulator for
      haemostatic plug formation in the rabbit mesenteric microcirculation.

PMID- 1036803
TI  - Molecular size distribution of fibrinogen derivatives formed in vitro and in
      vivo: a chromatographic study.
AB  - Using gel chromatography, fibrinogen derivatives present in purified systems or
      in biological fluids were separated and partially characterized. Eight groups of
      fibrinogen derivatives could be separated by gel filtration through 6% agarose in
      large columns, four with an elution volume smaller and four groups with an
      elution volume larger than that of fibrinogen. Careful calibration of the column
      allowed estimation of the diffusion coefficients of some of the derivatives and,
      thus, comparison with derivatives previously identified. Three, rather than two,
      groups of intermediate derivatives were observed during the degradation of human
      fibrinogen by plasmin in vitro or in vivo. One of these had a marked tendency to
      polymerize. A rather distinct difference in elution pattern was found between
      plasma obtained during streptokinase administration and from patients with
      intravascular coagulation.

PMID- 1036804
TI  - The effect of defibrinogenation on pulmonary embolism in dogs.

PMID- 1036805
TI  - Venous thrombosis in suspected pulmonary embolism: incidence detectable by
      Doppler ultrasound.

PMID- 1036806
TI  - Low-dose heparin and deep-vein thrombosis after total hip replacement.
AB  - The effect of subcutaneous low-dose heparin on postoperative deep-vein thrombosis
      (D.V.T.) (diagnosed by the 125I-labelled fibrinogen test) has been investigated
      in a trial of 143 patients undergoing the operation of total hip replacement. Two
      randomized studies were carried out: in one the scanning for D.V.T. was carried
      out daily for 7 days postoperatively andin the other for 15 days. In both, the
      incidence of D.V.T. was significantly lower in the heparin-treated patients (P
      less than 0.005). Bilateral D.V.T. was also prevented (P less than 0.05), through
      the extension of D.V.T. to the distal veins of the thigh was not significantly
      reduced. Heparin treatment was, however, followed by a higher incidence of severe
      postoperative bleeding (P less than 0.02) and wound haematoma formation (P less
      than 0.005), and the postoperative haemoglobin was significantly lower than in
      the control group (P less than 0.005). A higher number of transfused blood units
      was also needed by the heparin treated patients (P less than 0.001).

PMID- 1036807
TI  - Comparison between a modified ethanol gelation test and protamine sulfate test.
      Experimental studies.
AB  - A comparative experimental study has been made to correlate the protamine sulfate
      test and a modified ethanol gelation test, based on clinical observations of the
      solubility of a gel formed at 20 degrees C (Godal and Abildgaard procedure) when
      it was transferred to a bath at 37 degrees C. Two different results were
      obtained: the gel remained insoluble at 37 degrees C or it became completely
      soluble, with intermediate degrees of partial solubility. Our studies indicate
      that this is due to the amount of fibrin monomers formed and the level of
      fibrinogen: the first are responsible for the insolubility of the gel and the
      second for its solubility. This furnishes us with useful information for
      diagnostic purposes. We found the protamine sulfate test more sensitive than the
      ethanol gelation test, and its sensitivity increased when fibrinogen level
      decreased. An insoluble gelation test is a sure indication of the presence of
      fibrin monomers, but a soluble gel calls for the protamine sulfate test to
      confirm this or the existence of high fibrinogen level.

PMID- 1036808
TI  - Platelet preservation. II. The response of human platelet suspensions to
      hypotonic stress.
AB  - 1. Platelet suspensions were exposed to hypotonic stress. Several parameters of
      the changes in light absorbance were investigated i.a. the initial decrease in
      absorbance (A min), the maximal rate of the recovery process (V max), and the
      value of the absorbance two hours after mixing the platelet suspension with the
      hypotonic solution. 2. The ratio V max/A min appeared to be independent of both
      platelet concentration and, within a specific range, decrease in osmolarity. 3.
      Cryoprotectants appeared to disturb the response to hypotonic stress. 4.
      Cryopreservation caused a decrease in the light absorbance of the platelet
      suspension, of A min, and of the recovery process.

PMID- 1036809
TI  - Platelet preservation. III. The influence of dimethylsulfoxide and cooling
      conditions on serotonin uptake velocity and response to hypotonic stress of human
      platelets.
AB  - 1. Serotonin uptake velocity of human platelets was found to be reversibly
      inhibited by the presence of dimethylsfulfoxide (DMSO). 2. Incubation of platelet
      concentrates in the presence of DMSO for 90 minutes at room temperature decreased
      serotonin uptake velocity and response to hypotonic stress. 3. The serotonin
      uptake velocity was not substantially influenced by the temperature of incubation
      with DMSO. 4. The best recovery of serotonin uptake velocity after
      cryopreservation in the presence of DMSO was observed when DMSO was added quickly
      before cooling and removed quickly after thawing. 5. No significant differences
      were observed in serotonin uptake velocity and response to hypotonic stress
      cryopreservation in the presence of DMSO when cooling rates were varied from 2 to
      10 degrees C/min.

PMID- 1036810
TI  - Newborn platelet dysfunction: a storage pool and release defect.
AB  - Per cent aggregation, release and content of adenine nucleotides, and specific
      radioactivity were evaluated in citrated platelet-rich plasma (PRP) prepared from
      paired samples of maternal and cord blood. Platelets of newborn infants
      aggregated normally in response to highdose ADP (20 muM), strong collagen
      suspensions, and thrombin; however, when compared with PRP from the mothers or
      from normal adults, per cent aggregation in response to lower concentrations of
      ADP (2 muM), weak collagen, and part particularly epinephrine was markedly
      reduced. Nucleotide release after stimulation of the newborns' PRP with the
      latter two inducers was also impaired. ATP and ADP content of the newborns'
      platelets was also significantly less than that of their mothers or of normal
      adults, but specific activity was normal. The data suggest that the impairment of
      ADP release in the platelets of newborn infants is due to decreased sensitivity
      to external stimuli. Since metabolic ATP is necessary for the platelet release
      reaction, it is postulated that the platelet dysfunction results from a lack of
      metabolic ATP.

PMID- 1036811
TI  - The use of a chelating ion-exchange resin to evaluate the effects of the
      extracellular calcium concentration on adenosine diphosphate induced aggregation
      of human blood platelets.

PMID- 1036812
TI  - The effect of dimethyl sulfoxide on in vitro platelet function.

PMID- 1036813
TI  - The prothrombin time test: effect of varying citrate concentration.
AB  - Blood samples from 12 normal subjects and 46 patients on oral anticoagulants were
      divided so that each was anticoagulated with four concentrations of trisodium
      citrate solution in the range 0.09-0.15 M, 9 vol blood being added to 1 vol
      citrate solution in each case. Citrated blood haematocrit and plasma prothrombin
      time was measured on each subsample; 0.025 M CaCl2-solution was used for
      recalcification throughout. Three laboratories participated, each using a
      different prothrombin-time technique.

PMID- 1036814
TI  - Reference method for the one-stage prothrombin time test on hlman blood.
      International committee for standardization in hematology.

PMID- 1036815
TI  - Registry of prospective clinical trials second report.

PMID- 1036816
TI  - General classification system for hemorrhagic and thrombotic disorders.

PMID- 1036817
TI  - Report of the working party on platelets.

PMID- 1036818
TI  - Report of the working party on platelets. Stages in the interaction of platelets
      with collagen.

PMID- 1036819
TI  - Report of the working party on platelets. Platelet factor 4 (PF4), Platelet
      protein with heparin neutralizing activity.

PMID- 1036820
TI  - A micro-technique for determining platelet aggregability in whole blood.

PMID- 1036821
TI  - The effects of drugs on platelet function tests.

PMID- 1036822
TI  - Qualitative platelet abnormality due to absent collagen-induced aggregation.

PMID- 1036823
TI  - ADP, ristocetin, bovine factor VII and thrombasthenic platelets.

PMID- 1036824
TI  - Heparin and blood coagulation.

PMID- 1036825
TI  - Platelet aggregation by thimerosal.

PMID- 1036826
TI  - Detection and prevention of a fibrinolysis after an extra-corporeal circulation
      in cardiac surgery.

PMID- 1036827
TI  - Fibrin formation: the role of the fibrinogen-fibrin monomer complex.
AB  - The process of fibrin formation using highly purified fibrinogen and thrombin was
      studied using laser fluctuation spectroscopy, a method that rapidly determines
      particle size in a solution. Two periods in fibrin clot formation were noted: an
      induction period during which no fibrin polymerization occurred and a period of
      rapid increase in particle size. Direct measurement of fibrin monomer
      polymerization and fibrinopeptide release showed no evidence of an induction
      period. These observations were best explained by a kinetic model for fibrin clot
      formation incorporating a reversible fibrinogen-fibrin monomer complex. In this
      model, the complex serves as a buffer system during the earliest phase of fibrin
      formation. This prevents the accumulation of free polymerizable fibrin monomer
      until an appreciable amount of fibrinogen has reacted with thrombin, at which
      point the fibrin monomer level rises rapidly and polymerization proceeds.
      Clinically, the complex may be a homeostatic mechanism preventing pathological
      clotting during periods of elevated fibrinogen.

PMID- 1036828
TI  - Analysis of the disappearance curve of labelled fibrinogen at the time of
      hyperfibrinogenemia in rabbits with acute or chronic intravascular coagulation.
AB  - In order to study fibrinogen metabolism, the disappearance curve of 125I-abelled
      homologous fibrinogen was investigated in the rabbits with experimentally induced
      acute or chronic intravascular coagulation by injection of Lycopodium spores or
      thromboplastin. The results obtained were as follows. 1. Using haemolysate, an
      intermediate phase with upward convexity was clearly recognized between the early
      rapid-decay phase and the late slow phase in each radioactivity decay curve
      obtained in groups of rabbits. This convexity was most marked with acute
      intravascular coagulation induced by injection of Lycopodium spores, and was less
      marked, although higher, with chronic intravascular coagulation induced by
      injection of thromboplastin than that in the normal control. 2. The disappearance
      curve with the intermediate phase could be expressed, in approximation, as a sum
      of 2 equations--the initial exponential decay equation and the late parabolic
      one. 3. From the results obtained by separate examinations of the disappearance
      curve of plasma, fibrin clots and serum in rabbits with acute intravascular
      coagulation induced by injection of Lycopodium spores, the intermediate phase
      appears to be influenced more by the secondary increase of labelled non-clottable
      part tahn recirculation of the labelled fibrinogen. 4. The half time (27.4 hours)
      of the radioactivity in fibrin clots at the late phase observed in the group of
      rabbits with acute intravascular coagulation induced by injection of Lycopodium
      spores was shorter than that in the normal rabbits (50.2 hours). This fact may
      indicate that the increase of fibrinogen in the group of rabbits with acute
      intravascular coagulation induced by the injection of Lycopodium spores is due to
      overproduction of fibrinogen. 5. The half time of labelled fibrinogen should be
      calculated from disappearance curve of fibrin clots, instead from that of
      haemolysate or plasma.

PMID- 1036829
TI  - The recovery of factor VIII from fresh-frozen indated and outdated human plasma.
AB  - The availability of factor VIII concentrates is frequently a limitation in the
      management of classical hemophilia. Such concentrates are prepared from fresh or
      fresh-frozen plasma. A significant volume of plasma in the United States becomes
      "indated", i.e., in contact with red blood cells for 24 hours at 4 degrees, and
      is therefore not used to prepare factor VIII concentrates. To evaluate this
      possible resource, partially purified factor VIII was prepared from random
      samples of fresh-frozen, indated and outdated plasma. The yield of factor VIII
      protein and procoagulant activity from indated plasma was about the same as that
      from fresh-frozen plasma. The yield from outdated plasma was substantially less.
      After further purification, factor VIII from the three sources gave a single
      subunit band when reduced and analyzed by sodium dodecyl sulfate polyacrylamide
      gel electrophoresis. These results indicate that the approximately 287,000 liters
      of indated plasma processed annually by the American National Red Cross (ANRC)
      could be used to prepare factor VIII concentrates of good quality. This resource
      alone could quadruple the supply of factor VIII available for therapy.

PMID- 1036830
TI  - Failure of immunosuppression in a severe haemophilia B patient with specific
      antibody.
AB  - Prevention of a secondary response to factor IX by cyclophosphamide was attempted
      in an 11 year old patient with severe Christmas disease. An antibody to factor IX
      had been present for 4 years before immunosuppressive therapy was tried. Despite
      profound lymphopenia, synthesis of factor IX antibody was not depressed. The
      difficulties of modifying the anamnestic response to factor IX by chemical
      immunosuppression may be as real as has been reported for factor VIII in
      classical haemophilia.

PMID- 1036831
TI  - Comparison of the actions of thrombin and the thrombin-like venom enzymes ancrod
      and batroxobin.
AB  - Thrombin acts on several coagulant proteins to produce products with physiologic,
      pharmacologic and pathologic potential. The most sensitive thrombin substrate
      seems to be factor VIII. Some thrombin dependent reactions studied in vitro and
      proposed as control reactions seem too insensitive to the action of thrombin to
      be of in vivo significance. The only enzymic reaction the thrombin-like venom
      enzymes, Ancrod and Batroxobin, have in common with thrombin is the removal of
      fibrinopeptide A.

PMID- 1036832
TI  - Properties of human tissue thromboplastins from brain, lung, arteries, and
      placenta.
AB  - Properties of purified and delipidated human tissue thromboplastins (TTPs) from
      brain (BTTP), lung (LTTP), arteries (ATTP) and placenta (PTTP) were studied. The
      extinction coefficients were closely similar with a mean value of 8.3 +/- 0.01
      (SD). The molecular weights were 200,000 +/- 3,000 (SD) BTTP), 90,000 +/- 2,000
      (SD) (LTTP), 110,000 +/- 3,000 (SD) (ATTP) and 250,000 +/- 4,000 (SD) (PTTP). The
      maximum activity of each delipidated TTP after relipidation was obtained when
      phospholipid-delipidated TTP ratio was 2.0, and the maximum specific activity was
      440 units per mg BTTP, 270 units per mg LTTP, 80 units per mg ATTP and 600 units
      per mg PTTP. Ouchterlony analysis with anti-delipidated PTTP antibody showed the
      reaction of partial identity between delipidated TTPs and the antibody. Studies
      of the reactivity of I-125-delipidated TTPs with the antibody gave the following
      average values for % bound I-125-TTPs in 2 hours: 3.6 +/- 0.2(SD) % (I-125-BTTP),
      11.0 +/- 0.3 (SD) % (I-125-LTTP), 4.4 +/- 0.2 (SD) % (I-125-ATTP) and 13.7 +/-
      0.3 (SD) % (I-125-PTTP). It was also found that the antibody markedly neutralized
      the coagulant activity of saline extracts of brain, lung and placenta. These
      results indicate that delipidated BTTP, LTTP, ATTP and PTTP are different while
      being similar in some aspects and that complete TTPs are not coated with lipids
      in a manner inaccessible to anti-delipidated PTTP antibody.

PMID- 1036833
TI  - A new era in the laboratory evaluation of coagulation and fibrinolysis.

PMID- 1036834
TI  - Some observations on the preparation of platelet-rich plasma.
AB  - In order to prepare platelet-rich plasma a constant height and volume of citrated
      whole blood was centrifuged at different gravity forces and times. The
      supernatant plasmas were examined for platelet concentrations, plasma volumes and
      optical densities. Results are described showing that gravity force and time have
      an important influence on the platelet numbers and the plasma volumes recovered.
      The light attenuation by different concentrations of platelets in plasma, using
      light path lengths of 5 mm and 10 mm, was compared. The shorter light path
      provides greater linearity between optical density and platelet numbers
      especially at higher concentrations.

PMID- 1036835
TI  - Effects of matrix contact during gel filtration of human platelets in plasma.
AB  - When gel filtration is used to transfer platelets from plasma into an established
      environment, alterations in platelet characteristics may result from the change
      in environment or from the effects of platelet contact with the gel matrix. To
      approach the problem of evaluating the relative contributions from these sources,
      a Sepharose 2B matrix was employed and platelets transferred from citrate
      anticoagulated PRP into autologous PPP to yield plasma-GFP. Platelet recoveries
      averaged 93%. PRP: plasma-GFP pairs were found to be indistinguishable with
      respect to: morphology; ADP, thrombin or collagen-induced aggregation response;
      uptake of 5-hydroxytryptamine (5-HT) or adenosine; and thrombin or collagen
      induced release of accumulated 5-HT or adenosine. Pairs are distinguishable by
      prostaglandin E2 synthesis assayed immediately after filtration.

PMID- 1036836
TI  - Platelet dysfunction in migraine: effect of self-medication with aspirin.
AB  - Circulating microembolic index (CMI) was determined by drawing one blood sample
      into EDTA-formalin and the other into DTA alone in patients with migraine and
      compared with matched normal controls. Platelet aggregates, if any, are fixed in
      EDTA-formalin but disaggregated by EDTA. Ratios of these two counts approximate
      "unity" in normals and are proportionately less than unity, depending on the
      number of platelet aggregates. 26 untreated migraineurs and 19 migraineurs with
      history of self-medication with aspirin taken within 72 hours of the test, were
      studied in headache-free intervals. Results were compared with those from 20
      healthy, age and sex matched volunteers, without migraine, who were medication
      free for at least one week. Mean CMI in untreated migraineurs (0.77 +/- 0.03 SEM)
      was significantly lower than the mean in normal controls (0.94 +/- 0.02, p. less
      than 0.002). Migraineurs with self administration of aspirin had mean CMI of 0.88
      +/- 0.02, differing significantly from untreated migraineurs (p less than 0.01)
      but not from normal controls (0.1 less than p less than 0.2). Results suggest
      excessive platelet aggregation in migraineurs which tends to be corrected by
      treatment with platelet inhibitors such as aspirin.

PMID- 1036837
TI  - Effects of fasting on plasma and platelet-free fatty acids and platelet function
      in healthy males.
AB  - 10 healthy male volunteers fasted for 72 hours. Their plasma concentration of
      free fatty acid increased more than two-fold, to 1.8 mmol/l. The number of
      reversible venous "in vivo" platelet aggregates increased significantly (p less
      than 0.01); this figure correlated with the concentration of long-chain saturated
      free fatty acid in plasma (p less than 0.02). The correlation with the amount of
      long-chain saturated free fatty acid plus oleic acid (18:1) was even better (p
      less than 0.01). Plasma PF-4 concentration increased, suggesting increased
      platelet release reaction. In spite of the plasma increase, total platelet FFA
      concentration was reduced and there was a change in the distribution of platelet
      free fatty acid which correlated with the degree of aggregation.

PMID- 1036838
TI  - Sedimentation and adhesion of platelets onto a horizontal glass surface.
AB  - An experimental method for measuring platelet adhesion to a glass surface and
      platelet sedimentation rate is described. Anticoagulated platelet-rich plasma is
      placed on a horizontal glass slide for various contact periods. The number of
      platelets adhering to the slide per unit area is recorded as a function of time.
      The experimental results are used to verify theoretical predictions which account
      for the effect of the slow sedimentation rate of the platelets and for their
      escape over the potential barrier between them and the solid surface. By a least
      squares fit of the theoretical equation to the experimental data, both the
      platelet adhesiveness, in terms of P the probability to overcome the potential
      barrier, and the platelet sedimentation rate V are evaluated. A range of values
      of P and V for healthy humans is presented.

PMID- 1036839
TI  - Inhibition of ADP-induced platelet aggregation by adenosine tetraphosphate.
AB  - In contrast to previous reports, highly purified adenosine tetraphosphate (AP4)
      does not induce the aggregation of platelets but inhibits the aggregation and
      release reaction in platelet-rich plasma promoted by ADP. The inhibitory action
      of AP4 on the aggregation by ADP is compared with that of AMP and ATP. The data
      presented suggest a competitive manner of inhibition of the ADP-induced
      aggregation by AP4.

PMID- 1036840
TI  - Effect of platelet age on adhesiveness to collagen and platelet surface charge.
AB  - Adhesion to collagen was investigated as a function of platelet age in rat
      platelets. Platelet adherence was measured using EDTA-containing platelet- rich
      plasma which was added to preparations of collagen fibers clamped between
      magnetic stirrers by recording changes in light transmission. The plot of light
      transmission versus logarithm of time was linear and allowed calculation of a
      slope factor which related to the rate of adherence. Neither the amount of
      collagen nor the platelet count were limiting in the test. Young platelet
      populations (less than or equal to 1 day old) were obtained during the recovery
      phase from immune induced thrombocytopenia. Old platelet populations were
      prepared by blocking thrombopoiesis with cyclophosphamide. Young platelets showed
      a moderate but statistically significant increase in adhesivity to collagen but
      old platelets did not differ significantly from randomly aged platelets in this
      function. The electrophoretic mobility of platelets was not affected by their
      age.

PMID- 1036841
TI  - Inhibition of human and animal platelet adhesiveness to glass bead columns by
      adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid.
AB  - The differences among human, rabbit and guinea-pig platelet adhesiveness as for
      inhibitions by adenosine, dipyridamole, chlorpromazine and acetylsalicylic acid
      are described, and the influence of measurement conditions on platelet
      adhesiveness is also reported. Platelet adhesiveness of human and animal species
      decreased with an increase of heparin concentrations and an increase of flow rate
      of blood passing through a glass bead column. Human and rabbit platelet
      adhesiveness was inhibited in vitro by adenosine, dipyridamole and
      chlorpromazine, but not by acetylsalicylic acid. On the other hand, guinea-pig
      platelet adhesiveness was inhibited by the four drugs including acetylsalicylic
      acid. In in vivo study, adenosine, dipyridamole and chlorpromazine inhibited
      platelet adhesiveness in rabbits and guinea-pigs. Acetylsalicylic acid showed the
      inhibitory effect in guinea-pigs, but not in rabbits.

PMID- 1036842
TI  - Platelet aggregation following defibrination with ancrod.
AB  - In vitro platelet aggregation was studied in dogs following defibrination with
      Ancrod. There was marked inhibition of aggregation immediately after
      defibrination. A gradual return toward normal aggregation was observed over the
      96 hours study period, but aggregation was still abnormal at 96 hours after
      defibrination. There was an inverse and highly significant correlation between
      aggregation and fibrin degradation product level. Fibrinogen was not measurable
      after defibrination for the entire study period. Aggregation was thus independent
      of fibrinogen concentration in this study.

PMID- 1036843
TI  - Physico-chemical explanation of blood cell adhesion in thrombus formation.
AB  - A model is suggested which assumes that the rate of deposition of cells is
      determined both by hydrodynamic factors and by Brownian motion over the potential
      barrier caused by London and double-layer forces in the immediate vicinity of the
      deposition surface. The height of the barrier in the potential energy of
      interaction between blood cells and various surfaces is analyzed in relation to
      the physical properties of the cells, surfaces, and solutions. Based on this
      analysis, the adhesion of platelets to injured blood vessel walls and to non
      biologic materials, the lack of adhesion of red blood cells under the same
      conditions, the mechanism of ADP induced aggregation and the interaction with
      blood flow are explained. The qualitative predictions of the model are
      substantiated by available experimental information. Quantitative results are
      presented in terms of a time constant, which typifies a period of contact with a
      surface, during which appreciable deposition occurs.

PMID- 1036844
TI  - An immunological method for detection of the carrier of hemophilia B.
AB  - This paper presents the results of an immunological study of hemophilia B and its
      carriers which used two kinds of antibodies, a heterologous antibody of high
      specificity and a homologous antibody developed in a patient with severe
      hemophilia B. 1. The factor IX related antigen for hemophilia B could be
      determined by a neutralization test and not by a precipitation reaction. 2. The
      activity of factor IX in a definite carrier of hemophilia B was significantly
      lower than that of factor VIII in a definite carrier of hemophilia A. 3. In
      hemophilia B, there were no differences between the factor IX antigen determined
      by either the heterologous rabbit antibodies or the homologous antibodies. And
      there was no discrepancy between the factor IX antigen and the factor IX
      activity. Therefore, we cannot use this discrepancy for the detection of a
      carrier of hemophilia B. 4. However, there was a discrepancy between the factor
      IX antigen determined by the neutralization test and the factor IX procoagulant
      activity in the patients of both hemophilia BM and hemophilia B+. The identical
      results were obtained in the cases of carriers of both hemophilia BM and
      hemophilia B+. These facts are very useful for the detection of carriers of
      hemophilia BM and hemophilia B+.

PMID- 1036846
TI  - Hyperaggregability of platelets in thromboembolic disorders.

PMID- 1036845
TI  - Enhancement of fibrinolytic and thrombolytic potential in the rat by treatment
      with an anabolic steroid, furazabol.
AB  - The effect of long-term ingestion of an anabolic steroid, furazabol, was studied
      on coagulo-fibrinolytic systems in the rat. During the administration of
      furazabol at the daily dose of 0.04, 0.2 or 1 mg/rat for 3 months, the most
      remarkable changes were increase in the plasminogen activator activity in blood
      and the lung tissue and decrease in plasma fibrinogen level as well as decrease
      in plasma cholesterol. It was a very important finding that in most of the rats
      the furazabol treatment was effective in reducing susceptibility to lactic
      acidosis-induced pulmonary thrombosis. No meaningful changes were observed in
      other parameters tested including ADP-induced platelet aggregability, plasma
      recalcification time, plasma plasminogen, plasma antiplasmin activity,
      plasminogen activator content of tissues other than the lungs and the release of
      vascular activator induced by venous occlusion. One month after cessation of the
      furazabol treatment, these altered parameters tended to return to normal.
      Independently on the furazabol treatment, highly significant positive correlation
      existed between the plasma activator activity and the pulmonary tissue activator
      content. This indicated that the major source of plasma activator in the rat was
      the lung tissue and that the furazabol treatment increased the circulating
      activator activity through enhancing activator content in the lungs.

PMID- 1036848
TI  - Linear regression technique.

PMID- 1036847
TI  - Absorption of heparin by kaolin.

PMID- 1036849
TI  - Fibre inadequately replaced by cellulose or other forms of roughage in animal
      experimental diets.

PMID- 1036850
TI  - [Biologic effect of cosmic particle radiation, results of the Biostack
      experiments in the Apollo program].

PMID- 1036851
TI  - Geographical distribution of pediatric tumors.

PMID- 1036852
TI  - [Asthma in Netherton's syndrome. Apropos of 2 cases].

PMID- 1036853
TI  - [Arthrosis-inducing factors of meniscectomy].

PMID- 1036854
TI  - [The influence of straw, particularly rice straw, together with calcium-cyanamide
      on the microbiological activity of two Portuguese soils (author's transl)].
AB  - The influence of calcium-cyanamide upon the microbiological activity was tested
      in pot experiments under controlled conditions in two Portuguese soils (sandy and
      loamy) after the addition of rice or wheat straw (rice straw 0.275% N, wheat
      straw 0.307% N). The amount of straw was equalled to 100 dz/ha, the application
      of calcium-cyanamide to 25, 50 and 100 kg N/ha. In the containers treated with
      straw the total amount of microorganisms (Koch-method) was higher in sandy than
      in loamy soil after 30 days, but after 70 days it was higher in loamy soil. The
      content of active nitrogen (NH4 + NO3) increased, when calcium-cyanamide was
      added, but decreased after the application of straw. After 70 days sandy soil
      again showed an increase of active nitrogen. Straw increased the rates of CO2
      production considerably, wheat straw was superior to rice straw. Calcium
      cyanamide increased the CO2-production more in sandy than in loamy soil or German
      loess, which was also used for this experiment. Only in the case of rice straw
      higher doses of calcium-cyanamide had a positive effect. After 70 days the CO2
      production rose only when rice straw was applied. The dehydrogenase-activity was
      increased in both soils, but a superiority of wheat straw occurred in sandy soil
      only. The microbiological activity in the pots with straw was higher in sandy
      than in loamy soil, the addition of calcium-cyanamide accelerated it. Doses of 25
      50 kg N/ha are sufficient generally. The period of the formation of insoluble
      organic N-compounds, usually connected with the application of organic matter
      with a wide N:C-ratio, seems to be reduced by the addition of calcium-cyanamide.

PMID- 1036855
TI  - Biogenesis and production of cycloheximide by Streptomyces species.

PMID- 1036856
TI  - [Chemotherapy of the inoperable lymphosarcoma (author's transl)].
AB  - By means of chemotherapy it is not possible to heal the lymph osarcoma but to
      obtain remissions lasting up to 5 years in about 20% of the cases. The mode of
      therapy is discussed with regard to the generalized lymphosarcomatosis.

PMID- 1036857
TI  - [Studies on the distribution of hematopoietic bone marrow by bone marrow
      scintigraphy. I. The bone marrow distribution in hypoplastic anemia (author's
      transl)].

PMID- 1036858
TI  - [Studies on the distribution of hematopoietic bone marrow scintigraphy. II. The
      bone marrow distribution in leukemia (author's transl)].

PMID- 1036859
TI  - [Studies on the distribution of hematopoietic bone marrow by bone marrow
      scintigraphy. III. The bone marrow scintigraphy with 111In-chloride (author's
      transl)].

PMID- 1036860
TI  - [Determination of effective erythropoiesis rate by ferrokinetics in varios
      hematologic disorders (author's transl)].

PMID- 1036861
TI  - [Effects of androgens on erythropoiesis. In vivo and in vitro actions of
      androgens on erythropoiesis (author's transl)].

PMID- 1036862
TI  - [Studies on a plasminogen activating system in human milk: III. Formation
      mechanism of plasminogen activator by SK from the aspect of molecular weight
      (author's transl)].

PMID- 1036863
TI  - [Separation of factor VIII and factor XIII from human plasma (author's transl)].

PMID- 1036864
TI  - [Studies on immunoblastic lymphadenopathy in the New Zealand Black strain mice
      (author's transl)].

PMID- 1036865
TI  - [Problems on retinopathy of prematurity. --Statistical analysis of factors
      related to occurrence and progression of retinopathy, and fundus appearances and
      ocular functions in prematurely born subjects--(author's transl)].

PMID- 1036866
TI  - [Pathogenesis of the retinopathy of prematurity (author's transl)].

PMID- 1036867
TI  - [Treatment of acute proliferative retinopathy of prematurity with xenon-arc
      photocoagulation (author's transl)].

PMID- 1036868
TI  - The histological structure of dog knee menisci with comments on its possible
      significance.
AB  - Knee-joint menisci are poorly understood terminologically, structurally and
      functionally in spite of their almost universal occurrence in mammals and their
      considerable clinical significance in man. A study was therefore undertaken of
      dog knee menisci utilizing several histological techniques. Terminologically, it
      is proposed that the part of the meniscus extending between the anterior and
      posterior horns and exclusive of them be called the meniscal "body."
      Structurally, the horns and body differ in anumber of ways. The horns are oval in
      cross section, the body triangular. Hyalinized areas are much more frequent in
      the body than in the horns. The collagen of the horns is organized into discrete
      bundles that are separated from one another by loose connective tissue septa,
      while that of the body is arranged in a "herringbone" pattern; no septa are
      present in the body. Finally, the meniscal horns are richly supplied with blood
      vessels are nerves (including large myelinated fibers which apparently terminate
      in the horns) while the body is almost completely devoid of blood vessels and
      nerves. Functionally, it is hypothesized that knee-joint menisci may serve
      important sensory functions.

PMID- 1036869
TI  - Sex differences and psychiatric disorders.

PMID- 1036870
TI  - Race, achievement, and delinquency: a further look at Delinquency in a Birth
      Cohort.

PMID- 1036871
TI  - Economic strains and the coping functions of alcohol.

PMID- 1036872
TI  - [Study of the HL-A system in Basedow's disease (author's transl)].
AB  - HL-A typing has been carried out in 100 caucasians with Graves' disease and
      compared with 270 healthy controls. 25 HL-A antigens were characterized using a
      lymphocytotoxicity microtechnique. Analysis of the results reveals an increased
      incidence of HL-A8 antigen (35% in patients as compared to 16,3% in controls),
      with a high degree of statistical significance: p=0.0002 and corrected p X 25) =
      0.005. We did not observe a clearcut correlation between the presence of HL-A8
      and different characteristics of the disease: sex, age of onset, familial
      history, exophtalmia, goiter, severity. The knowledge of the relationships
      between the HL-A8 gene and several auto-immune diseases is a strong argument in
      favor of the auto-immune nature of Graves' disease. The association between HL-A8
      and Graves' disease could be explained by a close linkage between the second HL-A
      locus and one or several Ir-IgG loci occupied in predisposed individuals by
      predisposing alleles. In these subjects, an antigenic contact with an exogenous
      etiological agent would induce a pathological immune response, with production of
      thyroid stimulating IgG.

PMID- 1036873
TI  - [Morphological study of a prolactin-secreting pituitary adenoma after therapy
      with 2-bromo-alpha-erogocryptine (CB154) (author's transl)].
AB  - After treatment with CB 154 of a prolactin-secreting pituitary adenoma a
      morphological study reveales that many cells present a positive immunofluorescent
      reaction with anti-ovine prolactine antibody. At the ultra structural level, many
      granulations and vacuolated dense bodies can be observed.

PMID- 1036874
TI  - Anemia of azaribine in the treatment of psoriasis.
AB  - Azaribine is an effective agent in the treatment of psoriasis. In this
      investigation the extent of clinical dermatologic remission appeared to correlate
      with the degree of metabolic block induced by 6-azauridylic acid, as quantitated
      by the urinary excretion of orotic acid and orotidine, and the development of
      anemia. Following azaribine therapy there was a coordinate rise of the specific
      activities of erythrocyte orotate phosphoribosyltransferase and orotidine-5'
      monophosphate decarboxylase. There was no correlation between the pretreatment
      activity of these enzymes and the clinical response to azaribine. The anemia of
      azaribine therapy was mile and of a megaloblastic type. Uridine effectively
      corrected the azaribine-induced anemia, but led to exacerbation of the patients'
      psoriasis. Following uridine therapy there was a reduction in the urinary
      excretion of orotic acid and orotidine, presumable reflecting end-product
      inhibition or repression of the first steps of a repeated pyrimidine
      biosynthesis.

PMID- 1036875
TI  - [Methodologic principles of intervention in case of famine].

PMID- 1036876
TI  - Vitamin A in times of disaster.

PMID- 1036877
TI  - Ultrastructural study of testis in testicular feminization.
AB  - Testicular tissue was investigated by electron microscopy in a case of testicular
      feminization. The seminiferous tubules were lined by spermatogonia and by Sertoli
      cells. Spermatocytic maturation was not observed. Leydig cells were numerous and
      contained well developed, abundant vesicular smooth-surfaced endoplasmic
      reticulum and large mitochondria with tubulovesicular cristae. Reinke
      crystalloids were absent. The ultrastructural findings were consistent with the
      assumption that Leydig cells were under adequate stimulation and were in a stage
      of active secretion. Hence, the results seem to indicate that testicular
      endocrine function was maintained in the studied case.

PMID- 1036878
TI  - The ultrastructure of the interstitial cells in human fetal ovaries.
AB  - Steroid-active interstitial cells (stromal lutein cells) in human fetal ovaries
      of 12, 15 and 22 weeks of gestation were studied by means of electron microscope.
      The large cells, which are predominantly situated in the vicinity of capillaries,
      show high structural similarity to Leydig cells (type A) of the fetal testis.
      Both are characterized by extensively development of smooth endoplasmic
      reticulum, accumulation of lipids, and numerous mitochondria of the tubular type
      containing osmiophilic inclusions. Whether the interstitial cell system of the
      fetal ovary has any specific function in developmental physiology of the genital
      system cannot be decided on the basis of the present results. Its differentiation
      may only indicate adequate response of competent mesenchymal cells to
      gonadotropic stimulation.

PMID- 1036879
TI  - [The ratio birth-weight, placental weight and the term of delivery. A
      contribution to the problem of a relative placental insufficiency in late
      pregnancy (author's transl)].
AB  - It is suggested, that a relative placental insufficiency in late pregnancy is one
      of the releasing factors of childbirth. Under this assumption 1027 deliveries in
      term pregnancy (266th-294th day of pregnancy) were inquired on the
      interrelationship between the ratio brith-weight: placental-weight and the
      duration of pregnancy. The average birth-weight increases slighly but
      significantly with the duration of pregnancy just as the average placental
      weight. The average ratio birth-weight: placental-weight decreases significantly:
      The more unfavorable the ratio birth-weight: placental-weight is, the shorter
      remains the fetus in utero. This underlines the assumption of a relative
      placental insufficiency as one of the releasing factors of childbirth.

PMID- 1036880
TI  - [Experimental candida vaginitis in the mouse (author's transl)].
AB  - Manifest Candida albicans infection of the vagina of mice was achieved only after
      oestrogen treatment. Histologically, different phases of vaginal candidiasis
      could be observed: the mycotic infection began with a massive colonization of
      Candida albicans in the horny layers of the vaginal epithelium and an early
      immigration of granulocytes. Abscess-like changes followed when high number of
      yeast cells were used for infection. One to two weeks after onset the
      inflammatory changes decreased and fungi were no longer identifiable in
      epithelial micro-abscesses by the methods employed. In contrast, yeast cells
      could be detected within the vaginal skin exhibiting weak inflammatory lesions up
      to the 57th day. Chemotactic studies showed that the fungi considerably
      stimulated the migration of mouse granulocytes in the presence of serum. Since
      mannan isolated from the Candida cell wall also possesses strong chemotactic
      activity, certain components of the fungal cell wall may play a pathogenic role
      in Candida colpitis.

PMID- 1036881
TI  - [Histological diagnosis, DNA-content and chromatin pattern of breast cancer cases
      with positive and negative 17-beta-oestradiol receptor binding (author's
      transl)].
AB  - The DNA-concent of cell nuclei of 45 breast cancer cases of various histological
      structure has been determined cytophotometrically. With the exception of two
      gallert carcinomas no DNA-histogram of peridiploid range was found. The average
      DNA-content was 2--3 times higher as in the control tissue. The standard
      deviation of undifferentiated solid mammary tumors was the highest measured in
      this series. 24 of 45 cases had a negative oestrogen receptor binding. This was
      true in 60% of the undiffierentiated solid breast cancer cases, in 69% of the
      adenomatous and in 89 respectively 67% of the ones of special histological
      structure. The heterochromatin content of nuclei was lowest in the group of
      differentiated mammary cancer (50--60%). In the group of undifferentiated tumors
      it was 60--70%. So much for now is known about the mechanism of cellular action
      of 17-beta-oestradiol and the function of eu- and heterochromatin of cell nuclei
      it is discussed that positive or negative oestrogen hormone receptor binding in
      mammary tumor cells is probably a biochemical parameter of cytological
      desintegration. From this point of view these hormon receptors could be of the
      same value as the index of Barr bodies in breast cancer cells with respect of
      selection of cases for hormonal therapy. But this has to be analyzed in further
      studies extensively.

PMID- 1036882
TI  - Investigations into the preservation of human ovaries by means of a
      cryoprotectivum.
AB  - Human ovaries in the phase of follicular ripening were treated by means of a
      cryoprotectivum immediately after their removal. They were kept at --18degrees C
      for up to 8 weeks. After having gradually been thawed the ovaries were in vitro
      connected to a perfusion system. When completely revitalized they were examined
      in the steady-state for their metabolic behaviour. It was found that in
      comparison with the untreated controls, depending on the period of preservation,
      the oxygen consumption and the estrogen secretion had decreased, while the
      glucose absorption and lactate production had increased. As a morphological
      substrate a minor oedema was established in the tissue in the histological
      control after a preservation period of 2 months. This was mainly localized around
      the arteries. The method can be regarded as suitable for the preservation of
      ovaries for a limited period of time. It is possible to maintained a metabolism
      that can still be regarded as functioning.

PMID- 1036883
TI  - [Asteroid plastic surgery as optimum management of complete and partial vaginal
      occlusion (author's transl)].
AB  - Opinions differ about the type of surgical procedure to be applied in cases of
      complete or partial vaginal occlusion. The large percentage of postoperative
      vaginal stenoses and functional disorders necessitated a search for a new
      technique. The mucous membrane of the introitus vaginae is incised in the shape
      of a lying cross and the four flaps thus made are detached. Then an exactly
      lateral incision is made on each side of the crossing point described above
      resulting in a broad access to the vagina. Once the opening is wide enough, a
      second group of triangular flaps is formed vertically to this horizontal
      incision; the dimensions of the triangular flaps in the inner and outer group
      must be identical. Then the outer four flaps are turned inward and the four inner
      flaps are turned outward and interlinked so that a zig-zag line is formed which
      encircles the vagina in the area of the former stenosis. Thus far this surgical
      technique has been applied five times and yielded satisfactory results in every
      instance.

PMID- 1036884
TI  - A trend in the therapy of Amanita phalloides poisoning.
AB  - Recent experimental evidences have been produced on the protection afforded by
      penicillin G in rats poisoned by Amanita phalloides extracts. A therapeutic trend
      which combines penicillin G infusions to the classical supportive measures was
      applied to 33 cases of severe A. phalloides poisoning, with 100% survival rates.
      The possible mechanism of the protective effect of penicillin G in A. phalloides
      poisoning is discussed.

PMID- 1036885
TI  - The effect of N-alkyl groups of substituted phenyl-N-alkyl carbamates on the
      inhibition of human plasma cholinesterase.
AB  - The inhibition constants for human plasma cholinesterase (dissociation,
      carbamylation, decarbamylation, overall bimolecular rate constants) were
      determined for two series of substituted phenyl-N-alkyl carbamates. N-propyl
      carbamates were found to be better inhibitors than the corresponding compounds
      carrying smaller N-alkyl groups. In both series the carbamylation constants of N
      ethyl carbamates were lower than those of the N-methyl and N-propyl analogues,
      whereas the decarbamylation constants of the former were found to be higher than
      those of the latter carbamates. The experimental results obtained with human
      plasma cholinesterase are compared with published inhibition constants determined
      for several types of acetylcholinesterases.

PMID- 1036886
TI  - A death case involving tilidine.
AB  - A fatal poisoning case due to the combination of a relative overdose of
      barbiturates (600 mg daily) and 750 mg of tilidine is reported. The
      concentrations of barbiturates and tilidine with its metabolites were determined
      in blood, liver, and urine.

PMID- 1036887
TI  - Metabolic and toxic behavior of phthalimide derivates. I. Fate of imidan in the
      fetus.
AB  - The organophosphate insecticide imidan includes a phthalimide group. Because of
      the structural relationship to the teratogenic compound thalidomide we have
      investigated its placental transfer and metabolic fate in rats. Its passage to
      embryonic tissues could be confirmed. After intraamniotic injection to the first
      amniotic cavity of the left uteri we could establish a distribution of imidan and
      32P compounds throughout the uteri, the concentration depending upon the
      incubation time and the distances from the place of injection. The half-life of
      imidan, detected in the exterioized fetuses or in newborns, was 50--70 min.
      Imidoxon, i.e., the oxidized form of imidan, has a diminished half-life. This
      fact explicates the presence of imidoxon only in small concentrations after
      application of imidan.

PMID- 1036888
TI  - Therapeutic effects of some cholinolytics in organophosphate intoxications.
AB  - The therapeutic effects of pipethanate (sycotrol) and two newly synthetized
      cholinolytics, DPX-8 and ANC-51, were compared with atropine in mice poisoned by
      DDVP, fluostigmine, phospholine, and paraoxon. The antagonistic activotagonistic
      activity of tested drugs against acetylcholine-induced contraction of rat ileum
      and oxotremorine-induced salivation and tremor in the mouse was also studied. The
      anticholinergic activity of pipethanate, DPX-8, and ANC-51 was weaker than that
      of atropine. However,the therapeutic effect of pipethanate was higher than that
      of atropine in mice poisoned by the organophosphates. DPX-8 and ANC-51 afforded a
      better antidotal effect than atropine only in DDVP-poisoned mice.

PMID- 1036889
TI  - A universally applicable rapid bromine test.

PMID- 1036890
TI  - Experimental manganese lymphadenopathy in guinea pigs.
AB  - Experimental manganese lymphadenopathy was produced by guinea pigs by
      intratracheal inoculation of manganese dioxide (50 mg/300 g body weight) and
      histopathologic changes in the tracheobronchial lymph nodes were studied up to
      180 days. There was slow extracellular transport of manganese dust into the
      nodes, which did not provoke any significant reaction at early periods. However,
      at later periods the nodes exhibited a significant increase in the density of
      dust particles and the reaction consisted of phagocytosis, degeneration of dust
      laden macrophages, slight proliferation of fibroblasts, together with some
      reticulinosis corresponding to deposits of dust particles. The significance of
      these findings have been discussed from the chronic toxicity viewpoint.

PMID- 1036891
TI  - Biotransformation of As(III) to As(V) and arsenic tolerance.
AB  - The paper deals with excretion of As(III) and As(V) in the urine of mice exposed
      to a toxic concentration of As(III) (250 mg/1) in drinking water. After the
      exposures of 2, 6, and 8 days, the mice were given i.m. a solution of 74As(III)
      labeled sodium arsenite in a dose of 1.3 mg As(III)/kg b.w. and an activity of 3
      muCi/l ml. After the sacrifice of the animal, the urine was drawn off directly
      from the bladder. The urine samples were subjected to separation of As(III) from
      As(V) by using a paper radiochromatography technique. The results showed that
      unexposed control mice excreted one-half of the administered As(III) in the form
      of As(V). Mice exposed to arsenic in drinking water exceted already, after 2 days
      of exposure, four-fifths of the applied As(III) in the form of As(V), after 4
      days of exposure the proportion of As(V) was more than 95%, and after 8 days of
      exposure only traces of As(III) were present. The authors discussed the
      possibility of the biotransformation of As(III) to As(V) on arsenic tolerance.

PMID- 1036892
TI  - In vitro system for toxicological studies on the development of mammalian limb
      buds in a chemically defined medium.
AB  - In organ culture systems using the Trowell setup, morphogenetic differentiation
      (which largely mimics the development reached in vivo within 2--3 days) can be
      obtained in limb buds of mouse embryos during a culture period of 6 days. We
      succeeded in improving the technique and in achieving good differentiation of the
      limb buds in a chemically defined culture medium from which all additions of the
      heterologous serum used in previous studies were omitted. With this technique of
      using a chemically defined medium, the following results were obtained: (1) A
      high degree of reproducibility can be obtained in the grade of differentiation if
      the experimental conditions are standardized and limb buds of the same
      developmental stage (somite stage) are used. (2) The technique is applicable to
      species other than mice, such as rats and rabbits, however, the results obtained
      so far are not so satisfactory as those acquired with mouse limb buds. (3) In an
      attempt to offer some colloid osmotic pressure, macromolecules like
      polyvinylpyrrolidone (Periston), polydextrans (Macrodex) or polypeptides
      (Haemaccel) were added to the culture medium. None of these macromolecules had a
      beneficial effect on the differentiation of the limb buds in vitro; in the case
      of Macrodex the differentiation was even impaired. (4) In comparison with the
      development in a serum-containing medium, the results attained with a chemically
      defined medium are just as good when judged from microscopical and some
      biochemical studies (total content of DNA, RNA, protein, and protein-bound
      hydroxyproline in the explants). The applicability of the test system for the
      evaluation of embryotoxic effects is discussed.

PMID- 1036893
TI  - [The application of nitrogen detectors for arsenic determination in biological
      material (author's transl)].
AB  - An easy gc-determination of arsenic in biological samples with a nitrogen
      phosphorous detector is described. AsH3 is produced by reduction with NaBH4, and
      a sample introduced by the usual head space technique. The sensitivity of the
      method comes up to the concentration limits, which is of toxicologic interest.

PMID- 1036894
TI  - Determination of dextropropoxyphene and norpropoxyphene in autopsy material by
      gas chromatography.
AB  - A gas chromatographic method for the simultaneous determination of
      dextropropoxyphene and norpropoxyphene in autopsy material is described. The
      esters were hydrolyzed before the final determination. The mass spectra of the
      hydrolyzed esters are presented together with the results of an investigation of
      6 cases of fatal intoxications.

PMID- 1036895
TI  - X-ray crystallographic and gas chromatographic--mass spectrometric studies on
      norpropoxyphene.
AB  - The crystal structure of norpropoxyphene maleate is presented. The conformation
      is discussed in relation to similar compounds. A gas chromatographic--mass
      spectrometric investigation indicates that earlier proposed metabolites may be
      formed during the gas chromatographic separation.

PMID- 1036896
TI  - Introduction to the symposium "What is the importance of chronobiology in
      toxicology and pharmacology?

PMID- 1036897
TI  - Circadian fluctuations in the activity of DNA-dependent RNA polymerases I and II
      in the nuclei isolated from mouse tissues and the significance for
      pharmacological and toxicological studies on transcription.
AB  - For pharmacological and toxicological studies on the effect of drugs on
      transcriptional processes the basic fluctuation in activity during a 24-h period
      must be known. We have measured the activity of nuclear and mitochondrial DNA
      dependent RNA polymerases in cell fractions from mice kept under defined
      dark/light and feeding schedules. The following results have been obtained: 1.
      Circadian variations in the activity of RNA polymerases are especially pronounced
      in the nuclei of liver tissue. These changes depend predominantly on feeding
      habits and they are comparatively independent on the dark/light schedule. A
      maximum in the activity of nuclear DNA dependent RNA polymerases can be observed
      shortely after the beginning of the feeding period. 2. The nuclei isolated from
      other tissues, such as brain, kidney or embryos during the late stage of
      embryogenesis shown considerably smaller, if any, fluctuations in connection with
      the feeding habits. These tissues seem to be especially suitable for
      pharmacological or toxicological studies on transcriptional processes. 3. While
      both nuclear DNA-dependent RNA polymerases shown a strong dependence on the
      feeding habits no obvious circadian viriations can be observed in the activity of
      the DNA-dependent RNA polymerase localized in the mitochondrial fractions of the
      same tissue. The regulation of these polymerases in different cell compartments
      apparently occurs quite independently. The conclusions for the design of
      experiments on induction processes occurring in liver tissues, drawn from the
      results presented, are discussed.

PMID- 1036898
TI  - Possible influences of circadian rhythms in experimental carcinogenesis.
AB  - The induction of tumours by chemical carcinogens depends not only on the chemical
      structure of the substance but also on biological properties of the target cell
      population, such as enzyme patterns, DNA repair mechanisms and the proliferative
      state of the cells. Interference with any of these processes can theoretically
      affect the tumour yield, as can variations due to biological rhythms. A series of
      investigations of circadian and circannual rhythms in the hairless mouse
      epidermis (hr/hr) is reviewed. DNA synthesis as well as the mitotic rate undergo
      great variations in the course of a 24-h period. The respiration and glycolysis
      in this epidermis undergo strong circannual variations. Evidence that the
      eventual tumour development after methylcholanthrene application to the skin is
      modified by circadian variations in DNA synthesis is presented and discussed in
      relation to pertinent data from other cell systems.

PMID- 1036899
TI  - Genetic and hormonal regulation of steroid hydroxylases and drug metabolizing
      enzymes in rat liver.
AB  - Two microsomal steroid hydroxylase activities (cholesterol-7alpha-hydroxylase and
      progesterone-16alpha-hydroxylase) were measured in the livers of Sprague-Dawley
      and Wistar rats and compared to three other monooxygenase activities (aryl
      hydrocarbon hydroxylase, p-nitro-anisole-O-demethylase and aminopyrine-N
      demethylase). Cholesterol-7alpha-hydroxylase behaves in a very unique manner. It
      is the only one of the studied enzymes to be more active in the female than in
      the male, it is very poorly induced by phenobarbital and methylcholanthrene, but
      responds quickly to the administration of glucocorticoids. In fact, the
      cholesterol-7alpha-hydroxylase activity presents a very pronounced circadian
      rhythm which is under the control of the hypothalamo-adrenal axis. Marked
      differences are also found in the response of the various enzymatic activities to
      the administration of inducers as well as in their relative activities in
      untreated male and female animals.

PMID- 1036900
TI  - The circadian rhythm of synthesis and catabolism of cholesterol.
AB  - The circadian rhythms of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase
      (low values, during light, rising in the evening with maximum at 12.00 p.m.) are
      investigated in rats under diverse conditions. Intragastral administration of
      cholestyramine (bile acid-absorbing resin) leads to an increased rhythm of both
      enzymes. Feeding of cholic acid (or cholesterol) reduces the activity of both
      enzymes (of HMG-CoA reductase and cholesterol-7 alpha-hydroxylase, respectively).
      In starved rats enzyme activity and time of day is proportional to the metabolism
      of a substrate.ies are lowered, too; a damped rhythm reappears after 24 h. A 20%
      fat diet (containing saturated fatty acids predominantly) markedly reduces the
      high values. Enzyme activities inhabited after thyroidectomy can be normalized by
      thyroxin substitution. Thyroxin administration in the normal remains without
      effect. Four-day insulin treatment of the normal inhibits cholesterol-7 alpha
      hydroxylase, has no effect on HMG-CoA reductase. In the untreated diabetic rat
      cholesterol-7 alpha-hydroxylase is increased, HMG-CoA reductase significantly
      inhibited. Insulin treatment of the diabetic animal results in normalized values
      of HMG-CoA reductase whilst cholesterol-7 alpha-hydroxylase is nearly completely
      suppressed. The rate-limiting enzymes of cholesterol turnover are peripherally
      regulated by their products via a negative feedback. In contrast, hormones may
      have synergistic or opposite effects; thus they may represent means of higher
      regulation. All regulative possibilities discussed (except hypophysectomy) do
      modifiy the circadian rhythms. This cannot be demonstrated after hypophysectomy.
      After hypophysectomy circadian rhythms are not detectable any more. To get valid
      data about biochemical or pharmacological effects on these enzymes the circadian
      viriations have to be considered by measuring at different times of day (e.g. fat
      diet); for only the area of enzyme activit

PMID- 1036901
TI  - The manipulation of circadian rhythms.
AB  - In a study on male Wistar (TNO) rats kept under phase-shifted light-dark (12:12)
      conditions, it was demonstrated that the circadian rhythms of the following
      functions were effectively synchronized to the new lighting regimen: (a) body
      temperature, gross motor activity (after 1 week of acclimatization); (b) stomach
      weight, liver weight, liver glycogen, liver protein and acid phosphatase
      activity; serum corticosterone, glucose, total protein and inorganic phosphatase
      (after 4-6 weeks; as concluded from the data pooled of a sex of identical
      experiments); (c) the in vivo toxicity of approximately LD50 amounts (i.p.) for
      antimycin A and of E 600. In the individual experiments the various normal
      functions appeared to be different with respect to sensitivity to light. The
      overall pooled results indicated that, except for glycogen, the 24-h means of the
      normal values in the stomach, liver and serum were slightly decreased when
      compared to the respective means obtained from standard LD (= light: 6:00-18:00)
      conditioned control groups (P less than 0.001 for liver weight, liver protein,
      serum protein and inorganic phosphate). The experimental animals revealed an
      intermediate or persisting decrease of the growth rate. From the serial
      biological and toxicological studies performed in the course of 1 year, it is
      concluded that the synchronizing effect of an altered lighting regiment may be
      influenced by seasonal factors...

PMID- 1036902
TI  - Circadian rhythm of the renin-angiotensin-aldosterone system in the rat.
AB  - The 24 h-course of plasma renin activity (PRA), plasma aldosterone concentration
      (PAC), plasma corticosterone concentration (PCC) and of the urinary excretion of
      sodium, potassium and aldosterone was investigated in male Sprague-Dawley rats
      under different experimental conditions. The data obtained can be summarized as
      follows: 1. The renin-angiotensin-aldosterone system (RAAS) of the rat is subject
      to a circadian rhythm which is largely in phase with the well-known rhythm of the
      pituitary-adrenal axis. This rhythm can be demonstrated in PRA as well as in
      plasma concentrations and urinary excretion rates of aldosterone. The rhythm of
      urinary excretion of electrolytes is unlikely to be due to the rhythm of
      aldosterone secretion. 2. The light-dark cycle is the main synchronizer for these
      rhythms: inverting the light-dark cycle for 5 weeks entirely inverts the rhythms
      of all the parameters cited. 3. A dissociation of the rhythms of PRA and PAC can
      be observed following sodium restriction or dexamethasone treatment. A role of
      ACTH IN regulating the rhythmic pattern of aldosterone secretion is suggested by
      the finding that PAC and PCC follow the same pattern of circadian variations
      under every experimental condition tested. 4. The responsiveness of the RAAS to
      stimulation or suppression varies with the time of day. 5. It is suggested that
      experiments ought to be performed not only during the inactive (light hours) but
      also during the active (dark hours) phase when investigating the RAAS in the rat.
      This can conveniently be achieved by the use of an animal room with a reversed
      lighting regime.

PMID- 1036903
TI  - Circadian influences on clinical values in man.
AB  - 1. The circadian patterns of clinically relevant parameters were studied in 109
      young, healthy soldiers. 2. Erythrocytes, hematocrit, creatinine and cortisol
      exhibited very stable rhythmic patterns which were found by continuous
      examinations of the same persons as well as in examinations of different persons
      at different times. 3. The rhythmic patterns of leukocytes, blood glucose and
      body temperature were strongly influenced by stress caused by the first
      confrontation with an unknown hospital-like situation or by pain caused by blood
      sampling.

PMID- 1036904
TI  - The relevance of drug-induced organ pigmentation in animals.
AB  - Postmortem examination of animals from long-term safety evaluation studies often
      reveals pigment deposition in tissues. A review of several such observations is
      given and the possible chemical backgrounds of their origin are described, in an
      attempt to aid the determination of relevance in individual cases. It is
      suggested that one may be fairly broad-minded in the interpretation of the
      relevance of such pigments, especially if they are found only in one species, and
      have no influence on the function of the organs involved. A final answer comes
      only after administration of the particular drug to man, although he is normally
      dosed at all events one should not overvalue the relevance of pigmentation found
      in long-term animal studies.

PMID- 1036905
TI  - Teratogenicity and embryotoxicity of some maleinimides.
AB  - Maleinimide, the teratogenic structural "central part" of the thalidomide
      molecule, and 5 of its dichloro- and dibromo-derivatives have been investigated
      teratologically by tests on SWS mice. According to both the electrophilic
      properties and the spatial requirements of the substituents, the effects were
      found to be up to 100 times stronger than those of thalidomide, and up to 10
      times stronger than those of phthalimide respectively. The results are referred
      to the distinct electron-acceptor behavior of the maleinimide compounds, which-
      due to their flat molecular structures--are able to intercalate into the DNA
      double helix forming EDA complexes with nucleic acid bases as electron-donor
      molecules. The results can be interpreted as another confirmation of Jonsson's
      intercalation hypothesis of the thalidomide action.

PMID- 1036906
TI  - Neurotoxic effects of dichloroacetylene.
AB  - In inhalation tests involving lethal as well as sublethal doses of dias examined
      in rabbits by means ofhistologic and neurofunctional methods. Histologic
      examination revealed chromatolysis, disintegration of Nissl bodies, and cell
      shrinkage in proportion to the doses employed in the nuclei of the unpaired brain
      stem, in the sensory cortical regions and especially in the sensory cranial nerve
      nuclei. The sensory trigeminal nucleus was involved most severely, followed in
      decreasing intensity 0y the facial and oculomotor nerves and the motor trigeminal
      nucleus; the least changes were observed in the acoustic nerve. By testing the
      protopathic sensitivity of the facial skin it was possible for the first time to
      produce evidence of a sensory loss in the distribution of the trigeminal nerve by
      animal experimentation. The neuropathological and functional deficits observed
      may explain the cranial nerve lesions in human DCA intoxication; however, these
      lesions seem to be less distinct in experimental animals.

PMID- 1036907
TI  - Differential pulse anodic stripping voltammetry as a rapid screening technique
      for heavy metal intoxications.
AB  - This paper describes a relatively simple and rapid analytical procedure capable
      to carry out systematic screening for 10 heavy metals, namely mercury, bismuth,
      antimony, copper, lead, tin, thallium, indium, cadmium and zinc. Differential
      pulse anodic stripping voltammetry was chosen because of its simplicity, speed,
      low cost, low detection limits, screening potential for a wide selection of
      metals and the combined qualitative and quantitative output. The method of
      identification is based on measuring peak potentials in 2 different types of
      electrolyte solution, using 2 different electrodes. Complexing agents are used to
      mask certain elements.

PMID- 1036908
TI  - Binding of inorganic mercury by subcellllar fractions and proteins of rat
      kidneys.
AB  - Inorganic mercury, administered to rats in a single dose of 0.5 mg Hg/kg is
      accumulated in the kidneys mainly in the soluble (54%) and nuclear (30%)
      fractions, showing decreasing tendency with time. Mitochondrial and microsomal
      fractions, initially accumulating approx. 11 and 6% of total Hg, show a tendency
      to increase the absolute level of Hg for the first week after administration. In
      the soluble fraction low-molecular weight, metallothioneinlike proteins are
      mainly responsible for the accumulation of mercury, in other fractions proteins
      of higher molecular weight prevail.

PMID- 1036909
TI  - [A rapid carboxyhemoglobin determination by means of non-dispersive ultra-red gas
      analysis (author's transl)].
AB  - A rapid and reliable method of carboxyhemoglobin determination is described.
      Hemoglobin-bound carbon monoxide is released chemically into a continuous
      nitrogen stream and transported to an infrared gas analyser. The total amount of
      released CO is determined electronically. 100% CO Hb values are obtained in the
      same way from diluted blood samples after flushing with pure CO in special
      saturation vessels. The method described yields results with a standard deviation
      of +/- 2.5%.

PMID- 1036910
TI  - Irreversible protein binding of 14C-imipramine in rats in vivo.
AB  - Forty-eight hours after a single dose of 14C-imipramine to rats, 14C
      radioactivity could be measured in the following organs: liver greater than
      kidney greater than serum greater than fat greater than spleen greater than
      duodenum greater than lung greater than muscle and brain. Liver microsomes
      contained the main part of radioactivity derived from 14C-imipramine. After
      exhaustive extraction, only the proteins of liver, kidney, spleen, lung and serum
      contained measurable amounts of radioactive labeling. The greatest amount of 14C
      imipramine irreversibly bound to proteins was detected in liver microsomes. The
      question, as to whether the irreversible protein binding of imipramine, if it
      occurs during therapy, results in toxic side-effects, is discussed.

PMID- 1036911
TI  - Myocardial infarction due to mycotic coronary arterial aneurysm.

PMID- 1036912
TI  - [Synthesis and Quaternation of Pyridine-aldoxim Alkylethers (author's transl)].
AB  - Using known procedures, alkylethers of pyridine-aldoxime not described as yet
      were prepared and transformed into pyridinium salts. The application of a
      solution of a,a'-di-iodo-dimethyl-ether proved especially useful in the synthesis
      of bisquarternary salts with formaldehyde-acetal bridge. All the new substances
      are ineffective in a paraoxon poisoning. On the other hand, some salts show
      protective action in soman intoxication.

PMID- 1036913
TI  - Release of highly soluble substances from inert matrices in cases of two-sided
      attack of the solvent.
AB  - The present work is an extension of some of our earlier investigations on the
      release of soluble substances in inert matrices. There have been described the
      cases of two-sided attack on the inert matrices (PVC and PE) by the solvent. The
      theoretical considerations of the cases for the two-sided attack were
      experimentally confirmed. The values of the diffusion coefficients, which
      correspond to the calculated ones in the cases of one-sided attack, were
      calculated as well.

PMID- 1036914
TI  - Spectral mapping, a technique for classifying biological activity profiles of
      chemical compounds.
AB  - A mathematical technique is described that separates potency from spectral
      information in biological activity spectra. The technique is a preliminary step
      in the classification of chemical compounds and in the structuring of
      pharmacological assays. The method is illustrated using previously reported
      results on 40 neuroleptics in 12 assays on rats. Principal component analysis and
      cluster analysis are shown to provide complementing information.

PMID- 1036915
TI  - [On the simultaneous effects of ionising radiation and chemical agents on animal
      cells. 1st communication. Cytogenetic studies on X-rays and isonicotinic acid
      hydrazide in the Chinese hamster, Cricetulus griseus (author's transl)].
AB  - In bone marrow cells of Chinese hamsters enhanced chromosome damage is observed
      after 48 h treatment of the animals with isoniazid (INH) combined with X-rays
      only at much higher doses than normally applied in human therapy. Compared to X
      ray-induced aberration levels, 125 mg/kg INH and 50 R given simultaneously
      increase the number of gaps and breaks, the latter being increased over
      additively. This points to an interaction between both agents. The combined
      treatment changes the mitotic rate of the bone marrow as well.

PMID- 1036916
TI  - Classification of psychoactive drugs by visually evoked potentials in rabbits by
      means of multiple discriminant analysis. A possible way of predicting the
      clinical efficacy of new psychoactive drugs.
AB  - The influence of representatives of various groups of antipsychotic drugs on the
      visually evoked potential (EP) was investigated with the aid of a modified
      recording and evaluation technique for the rabbit EEG from cortical and
      subcortical structures. The starting point was the hypothesis that changes in the
      EP in animal experiments caused by representative members of these "substance
      groups" (neuroleptics with predominantly antipsychotic or predominantly sedative
      effect, and antidepressants with predominantly mood-brightening or predominantly
      sedative main components) make predictions of the clinical efficacy of "unknown"
      substances possible on the basis of clinical therapeutic principles of
      classification. Experiments were carried out with haloperidol and fluphenazine,
      chlorpromazine, amitriptyline and doxepin, and with imipramine and clomipramine,
      as representatives of these classes of substances. The hypothesis was checked by
      attempts to assign amitriptyline and chlorprothixene in varying dosage,
      haloperidol, benzperidol and mianserine to appropriate classes. As classification
      and assignment procedure we used stepwise multiple discriminant analysis (SWDA)
      according to our modification of the BMD 0 7 M Program. The purpose of the latter
      program, and its applicability to our studies, are described and discussed. It
      was found 1. that with EP data from animal experiments it is possible to classify
      various groups of psychoactive drugs on the basis of clinical therapeutic
      findings, using SWDA; 2. that assignment of "unknown" compounds can be based on
      this classification; 3. that hence with some caution predictions of the clinical
      effect of newly developed substances may be made on the basis of findings in
      animal experiments. The EP variables which contain most information for making up
      the separation formula and hence are of special importance, are investigated with
      respect to their possible neurophysiological evidential value, and their
      significance is discussed. It was found that the EP from the visual cortex are of
      particular significance for the separation of groups in the form presented here.

PMID- 1036917
TI  - [Pharmacological Properties of Fendiline in Cardiac and Smooth Muscle (author's
      transl)].
AB  - The pharmacological properties of fendiline N-(1-phenylethyl [1])-3,3 -
      diphenylpropylamine-hydrochloride; Sensit, were investigated in the isolated
      guinea pig heart and in isolated circular smooth muscle strips of bovine coronary
      arteries, pulmonary arteries and trachea. 1. Fendiline dose dependently increased
      coronary flow by up to 200% but, different from verapamil, did not inhibit
      contraction. 2. Fendiline dose dependently relaxed  coronary strips and, more
      powerfully, tracheal and pulmonary arterial strips. 3. In cardiac muscle,
      fendiline was almost completely retained for a prolonged period of time. In the
      smooth muscle tissues under study, fendiline accumulated twenty-fold above the
      concentration present in the organ bath. 4. In paced hearts, fendiline non
      competitively inhibited the positive inotropic effect of isoprenaline in doses
      that did not significantly depress the amplitude of isotonic contractions. 5. In
      the guinea pig heart, adenosine uptake becomes progressively inhibited when
      coronary flow increases. This "washout" effect was definitely counteracted by
      fendiline and by NaNO2, but was augmented by papaverine, hexobendine and
      dipyridamol. The counteraction of the "washout effect" by fendiline as well as by
      NaNO2 is most likely due to the opening of additional (previously closed)
      capillaries.

PMID- 1036918
TI  - Differences in the cardiac actions of the calcium antagonists verapamil and
      nifedipine.
AB  - 1. It was investigated whether the calcium antagonistic coronary drugs verapamil
      and nifedipine have similar antiarrhythmic properties. Their effects on
      functional refractory period and contractile force in the isolated left guinea
      pig atrium were compared. To assess their influence on myocardial excitability
      the relation between threshold voltage and pulse duration was studied in the left
      guinea pig atrium. Furthermore, the influence on AV conduction was investigated
      in the conscous dog in haemodynamically equieffective dose ranges. 2. Verapamil
      as well as nifedipine cause a dose-dependent prolongation of the functional
      refractory period in the isolated left guinea pig atrium. The slope of the dose
      response curve of nifedipine is, however, significantly less steep than that of
      verapamil. Maximum prolongation of refractory period which can be induced by
      nifedipine is significantly inferior to that occurring after verapamil; under
      nifedipine this prolongation is, however, accompanied by a significantly greater
      reduction in contractility. 3. In the isolated left guinea pig atrium the voltage
      duration curve is shifted to the right and the chronaxia value is significantly
      increased by verapamil. Even in the highest dose possible nifedipine has no
      effect on atrial excitability. 4. In the conscious dog verapamil considerably
      prolongs AV conduction time whereas a moderate yet dose-dependent shortening of
      PQ duration is observed with equieffective nifedipine doses regarding the
      decrease in blood pressure and increase in heart rate. 5. The results indicate
      that nifedipine does not exert antiarrhythmic effects comparable to those of
      verapamil.

PMID- 1036919
TI  - [The effect of n-butanol on the metabolic status of some organs of rats and the
      circulation of rabbits].
AB  - Rats received n-butanol i.m. in a dose of 0.1 g/kg body weight/die during 50
      days. The metabolic status of some organs was examined and compared to that of
      rats which in control experiments had received 0.9% NaCl-colution in an
      equivalent volume (double blind experiments). The tissue levels of metabolites of
      the adenylic acid-creatine phosphate system, of glycogen, glucose and lactate
      exhibited no significant differences in both the groups. In the liver the tissue
      level of glycogen, free creatine and total creatine was significantly elevated in
      rats which had received n-butanol. In concious rabbits the effect of n-butanol on
      circulatory parameters was investigated in double blind experiments. n-butanol
      was without a significant effect in a dosage of 0.008 g/kg. A dosage of 0.033
      g/kg and particularly of 0.1 g/kg resulted in a transitory decrease in the heart
      rate and the systolic and especially diastolic blood pressure.

PMID- 1036920
TI  - Experiments on the detection of the carcinogenic N-nitroso-dimethylamine in the
      urine of rats after oral administration of the analgesic amidopyrine and nitrite.
AB  - N-Nitroso-dimethylamine (NDMA) was excreted unchanged in the urine of rats after
      oral administration of the compound in amounts ranging from 0.003% at a dose of 2
      mg/kg to 0.08% at a dose of 15 mg/kg. By measurement of the NDMA excreted after
      oral administration of amidopyrine and nitrite, the extent of nitrosation in vivo
      was estimated to be about 30%. For clinical investigation of NDMA formation in
      patients treated with amidopyrine, however, we consider this method to be too
      insensitive.

PMID- 1036921
TI  - [Isolation and structure determination of metabolites of xantinol from rat urine
      (author's transl)].
AB  - In the urine of rats as metabolites of the theophylline-derivative 7-[2-hydroxy -
      3 - (N-methyl-N-2-hydroxyethyl)-amino-propyl]-1,3-dimethylxanthine (xantinol),
      the two stereoisomeric 2-coffeinyl-N-methyl-6-hydroxy-morpholines were found.
      These compounds represented about 7 to 8 percent of the eliminated xantinol and
      can be described structurally as semiacetals of a terminal aldehyde formed from
      Xantinol. Their structure has been elucidated by combined NMR- and mass
      spectrometry. After oral application of xantinol-nicotinate in therapeutic doses
      to male test subjects, the same substances were detected by thin-layer
      chromatography. Both compounds could be synthetized by treatment of 7-[2,3
      epoxypropyl]-theophylline or 7-[2-hydroxy-3-chloro-propyl]-theophylline with
      methylami-noacetaldehyde-dimethylacetal and subsequent hydrolysis of the reaction
      product with hydrochloric acid.

PMID- 1036922
TI  - Secretion and irrigation of gastric mucosa during disulfiram effect. Experimental
      study in the dog.
AB  - The effect of ethyl alcohol and disulfiram (Antabuse) on the secretion and the
      irrigation of an isolated and denervated gastric pouch has been studied in the
      dog. In these conditions, disulfiram increased the differential acidity; the
      association of ethanol with disulfiram impaired the proteolytic activity of the
      secretion and induced a hyperirrigation of the gastric mucosa more definite than
      with ethanol alone. Effects on ethanol absorption from stomach are discussed.

PMID- 1036923
TI  - Pharmacological properties of thiazolinobutazone (LAS 11 871). III. General
      pharmacology, ulcerogenic effects and acute toxicity.
AB  - 2-Thiazoline - 2 - ammonium-4-n-butyl-1,2-diphenyl-3,5-pyrazolidinedionate
      (thiazolinobutazone, LAS 11 871, Fordonal) has been compared with phenylbutazone
      in a variety of pharmacological tests with a view to side effects and toxicity.
      Thiazolinobutazone was the less toxic (acute LD50) and the less ulcerogenic
      molecule of the two and, in contrast to phenylbutazone, was not antidiuretic.
      Some signs of activity on the autonomic and somatic nervous systems were seen
      following high doses of thiazolinobutazone which appeared to be related to
      inhibition of cholinesterases.

PMID- 1036924
TI  - Bromperidol, a new potent neuroleptic of the butyrophenone series. A comparison
      of the effects of bromperidol and haloperidol in intracranial self-stimulation.
AB  - Bromperidol, a new potent and long-acting neuroleptic of the butyrophenone
      series, and haloperidol were injected s.c. at the doses 0.01, 0.02, 0.04 and 0.08
      mg/kg, in rats implanted with electrodes in the lateral hypothalamic region of
      the medial forebrain bundle. A dose-related response inhibition was found with
      both compounds and the graphically estimated ED50 value was 0.041 mg/kg for
      bromperidol and 0.047 mg/kg for haloperidol. These data are in complete agreement
      with our previous findings that bromperidol is a new potent and specific
      neuroleptic.

PMID- 1036925
TI  - [Cholinergic contraction of the dog urinary bladder by electrical stimulation of
      the n. pelvicus and the ligamenta lateralia nerves and its affection by atropine
      and scopolaminebutylbromide (author's transl)].
AB  - As is well known contraction of the urinary bladder induced by electrical
      stimulation of the N. pelvicus-hypogastric plexus in the dog can only be
      diminished by atropine but not completely abolished. The result of stimulation
      can, however, be quantitatively abolished by the quaternary ammonium base
      hyoscine-n-butylbromide (scopolaminebutylbromide, Buscopan). Apart from
      antimuscarine-like peripheral effects, Buscopan also possesses, in contrast to
      atropine, antinicotine-like ganglion-blocking properties. Since Buscopan
      possesses only anticholinergic properties the contraction triggered off by
      stimulation of the nerve can be considered as being purely cholinergic. In the
      collateral ligaments of the urinary bladder of the dog there is another nervous
      system which when electrically stimulated contracts the bladder. Depending on the
      dosage the effect of stimulation can be diminished or abolished by atropine as
      well as by Buscopan. The result of stimulation can be diminished by hexamethonium
      and increased by eserine (physostigmine). Because of the effect of atropine
      Buscopan (inhibition) and eserine (increase) this nervous system can be
      characterised pharmacologically as cholinergic.

PMID- 1036926
TI  - The effect of rifamycin SV on the wound-healing process.
AB  - The influence of rifamycin SV on the healing process of a wound was studied in
      animal experiments. Measurement of the degree of cicatrization, determination of
      the free hydroxyproline in serum, and histological findings helped to demonstrate
      that local application of rifamycin SV leads to an increased fibrinous
      conglutination of the lips of the wound at an early phase of the healing process
      and the subsequent formation of fibres in the regenerative tissue is not
      impaired.

PMID- 1036927
TI  - [Penetration, permeation and resorption of heparin. In vivo studies on human
      skin].
AB  - The penetration and permeation of radioactive heparin into human skin was
      investigated as well as absorption and excretion. Heparin concentrations and
      vehicles were those that are in common use in practical therapy. It was shown
      that in spite of its high molecular weight, heparin can penetrate through the
      intact horny layer barrier. The concentration of heparin found in the skin, e.g.
      10 I.U./ml in the epidermis and 0.6 I.U./ml in the corium are biologically
      relevant and are expected to be able to exert an influence. The penetration rates
      have shown a clear dependence on the kind of vehicle.

PMID- 1036928
TI  - [Isolation and characterisation of two main metabolites of ifosfamide from human
      urine (author's transl)].
AB  - Two main metabolites of the cytostatic agent 1,3,2-oxazaphosphorine-3(2
      chloroethyl)-2-[(2-chloroethyl)-amino]-tetrahydro-2-oxide (ifosfamidd as two
      different dechloroethylated derivatives. They both can also be derived from
      ifosfamide in vitro by means of KMnO4-oxidation. The metabolites are stable in
      organic solutions and they show no cytotoxic activity in biological test systems.
      In the urine of a patient treated with ifosfamide, nearly 50% of the applied dose
      were excreted as dechloroethylated derivatives. In the urine of other patients
      "carboxyifosfamide" was the main metabolite. It is assumed that the therapeutic
      effect of ifosfamide depends partially on whether side chain oxidation or ring
      oxidation is the predominant way of biotransformation.

PMID- 1036929
TI  - [The geriatric pharmacology of cefazolin, cefradin and sulfisomidine].
AB  - Clinical pharmacology of 3-(5-methyl-1,3,4-thiadiazol-2-ylthiomethyl)-8-oxo-7
      (tetrazol-1-ylacetamido)-5-thia-1-azabicyclo-(4,2,0)oct-2-en-carbonic acid
      (cefazolin) and D-7-[2-amino-(cyclohexa-1,4-dien-1-yl)-acetamido]-3-methyl-8-oxo
      5-thia-1-aza-(4,2,0)-oct-2-ene-2-carbonic acid monohydrate (cefradine) was
      compared in young and old adults without renal disease after i.v. injection of 1
      g. Mean serum levels of cefazolin after 4 h and 6 h were significantly higher in
      old persons (25.0 and 14.7 mug/ml, resp.) than in young persons (16.2 and 7.8
      mug/ml, resp.). Serum concentrations of cefradine after 2 and 4 h were found also
      higher in the aged (11.2 and 4.4 mug/ml, resp.) than in young adults. Half-life
      of cefazolin was prolonged from normally 94 min to 189 min, half-life of
      cefradine from 32 min to 72 min. Skin blister fluid punctured once for antibiotic
      assay contained less cefazolin in old persons (after 4 and 6 h only 22.4 and 17.4
      mug/ml, resp.) than in young persons (32.7 and 27.6 mug/ml, resp.). Cefradine
      levels in skin blister fluid 0.5 and 1 h after i.v. injection showed also a
      significant difference (11.4 and 11.9 mug/ml, resp.) in old persons, 17.3 and
      16.5 mug/ml, resp., in young persons). Elimination constants (alpha, beta, kel,
      k12, k21) were always lower in geriatric patients. Renal clearance of cefazolin
      was reduced from 83 ml/min to 43 ml/min, and renal clearance of cefradine from
      378 ml/min to 152 ml/min. After i.v. injection of 1 g 6-sulfanilamido-2,4
      dimethyl-pyrimidine (sulfisomidine) total content of the drug in blood was higher
      in elderly people than in young persons, but proportion of acetylated
      sulfisomidine was nearly the same in both groups (15%). It is supposed that
      higher serum levels of some drugs in old persons (over 70 years) can be explained
      by impaired renal excretion and slower tissue penetration of the compound from
      the blood.

PMID- 1036930
TI  - Pharmacokinetics of coumarin upon i.v. administration in man.
AB  - The disposition pharmacokinetics of coumarin has been studied after i.v.
      administration in man, and might be described best by an open two-compartment
      model. Three dose sizes have been studied, 0.125, 0.2 and 0.25 mg/kg. The mean
      biological half-life was found to be 1.81, 1.45 and 1.49 h, respectively, for the
      three dose sizes. Coumarin is extensively distributed. The volume of the central
      compartment apparently comprises the extracellular and intracellular fluid. The
      study indicates dose-dependent (non-linear) pharmacokinetics with respect to
      distribution.

PMID- 1036931
TI  - Cobalt-induced experimental epilepsy in cats pharmacologically immunodepressed.
      An EEG and histological study.
AB  - The authors made 11 adult cats epileptic by implanting cobalt powder on the left
      sensorimotor cortex. Some of the animals were treated with the immunodepressant
      drug, cyclophosphamide (Endoxan), before and after surgery, and others were not.
      Then the two groups of animals were compared in terms of EEG and
      histopathological findings. The treatedanimals showed a definite reduction of
      focal electrical activity both primary and secondary, and a much milder perifocal
      parvicellular infiltration and cerebral edema. In view of these findings, the
      authors suggest that in addition to other well-known factors, the pathogenesis of
      cobalt-induced experimental epilepsy involves immunological mechanisms triggered
      by the release of nerve tissue antigens as a result of tissue injury caused by
      cobalt. This would result in the formation of antibodies directed against several
      brain constituents. Last, the authors submit that a similar autoimmune mechanism
      may be at play also in the pathogenesis of some forms of focal epilepsy of
      traumatic origin.

PMID- 1036932
TI  - [Animal studies on the tolerability of NAB 365 (clenbuterol) (author's transl)].
AB  - The findings of acute, subacute and chronic toxicity studies in rats and dogs
      with the new beta-mimetic agent 4-amino-alpha-[(tert.-butylamino)methyl]-3,5
      dichlorobenzyl alcoholhydrochloride (NAB 365, clenbuterol) are reported. The
      longest period of investigation, with daily oral administration of the substance,
      was 18 months (rats) and 12 months (dogs). No abnormalities of any kind were
      found in the rat studies which could be attributed to the substance. The
      administration of clenbuterol to dogs produced microscopically small lesions in
      the myocardium which were not dose-dependent and which were localised entirely in
      the papillary muscle of the left ventricle. The reason for these lesions was that
      dogs react to the substance with severe tachycardia, as a consequence of a
      reduction in diastolic blood pressure produced even by very low oral doses.
      Oxygen deficiency occurs which affects particularly the papillary muscle. The
      response to hypoxia is better capillarisation. This causes an improvement in the
      oxygen supply, which in turn prevents the spread of existing necroses and the
      development of further lesions.

PMID- 1036933
TI  - [Reproduction-toxicologic tests with a new beta-mimetic agent clenbuterol (NAB
      365) (AUTHOR'S TRANSL)].
AB  - The reproduction-toxicologic tests on rat and rabbit yielded no indication of a
      teratogenic potency of the beta-mimetic agent 4-amino-alpha-[(tert.
      butylamino)methyl]-3,5-dichlorobenzyl alcohol-hydrochloride (clenbuterol, NAB
      365). The fertility test showed no signs of reduced fertility. Excessive dosage
      of NAB 365 to pregnant rats led to an increased mortality of the pups during the
      neonatal period. A dosage of 1 mg/kg is regarded as the maximum tolerated dosage
      in perinatal toxicity tests.

PMID- 1036934
TI  - [Electron microscopic study of guinea pig tracheal epithelium after
      administration of NAB 365 (author's transl)].
AB  - After application of 4-amino-alpha-[(tert.-butylamino)methyl]-3,5-dichlorobenzyl
      alcohol hydrochloride (clenbuterol, NAB 365) the following changes in the
      secretory cells of the tracheal epithelium of the guinea pig can be visualised by
      electron microscope: 1. increase of membrane-bordered structures which might be
      regarded as primary lysosomes, 2. a faster and more pronounced loosening of
      secretion granula. These findings suggest a selective site of action of the
      substance at the lysosomal system. It is stimulated, loosens the secretion
      intensively already within the cell, and possibly develops some activity even in
      the lumen. These conceptions can serve as an explanation of the clinically and
      experimentally demonstrated secretolytic effect.

PMID- 1036935
TI  - [Pharmacokinetics and metabolite pattern of clenbuterol in the rat].
AB  - Pharmacokinetics and metabolite pattern of the beta-sympathomimetic 4-amino-alpha
      [tert.-butylamino)methyl]-3,5-dichlorobenzyl alcohol hydrochloride (clenbuterol,
      NAB 365) have been investigated in the rat. After a single i.v. dose of 2 mg/kg
      14C-NAB 365 up to 10 min p.a. the blood level falls very steeply and 15 min p.a.
      there is an increase to be observed. A maximum blood level of 0.85 mug eq. NAB
      365/ml is achieved. Then a biphasic elimination of radioactivity from the blood
      occurs. After a single oral dose of 2 mg/kg the maximum blood level of 0.5 mug/ml
      is attained 2 h p.a. Again a biphasic elimination occurs. 26 h is the half-life
      of the slower of two elimination processes for i.v. and p.o. administration,
      respectively. Elimination predominantly takes place via the kidneys. After i.v.
      administration 85% and after p.o. administration 80% of the radioactivity applied
      are eliminated in urine and faeces. The main portion of radioactivity had been
      eliminated by 48 h p.a. As can be seen from the urinary radioactivity absorption
      is complete. Following i.v. dosing the excretion is slightly faster than after
      p.o. administration. Whole-body autoradiography and the distribution of
      radioactivity in the organs show a relatively slow absorption after p.o. dosing.
      In the pregnant mouse the placenta barrier is passed but the fetuses contain far
      less radioactivity than the mother animal. Clenbuterol is metabolized in the rat.
      70% of the radioactivity represents the unchanged parent compound in urine (38%
      of the administered radioactivity). 8 metabolites have been established in urine
      (extracts). Faeces radioactivity mainly contains unchanged clenbuterol and only
      traces of metabolites. The metabolite pattern of the maximum plasma level (2 h
      after p.o. administration) and the metabolite pattern of the collected urines are
      identical. 38% of the administered radioactivity represent unchanged NAB 365 in
      the urine, whereas there are 45% in the plasma.

PMID- 1036936
TI  - [Pharmacokinetics and metabolite pattern of clenbuterol in rabbit and dog
      (author's transl)].

PMID- 1036937
TI  - [Single and multiple applications and metabolite pattern of clenbuterol in man
      (author's transl)].

PMID- 1036938
TI  - [Comparison of the pharmacokinetic profiles of clenbuterol in rat and dog during
      toxicological studies (author's transl)].
AB  - The pharmacokinetics of the beta-sympathomimetic 4-amino-alpha-[(tert.
      butylamino)methyl]-3,5-dichlorobenzyl alcohol hydrochloride (clenbuterol, NAB
      365) have been investigated in two animal species during the chronic
      toxicological studies after single and multiple dosing. After oral administration
      of 2.5 mg/kg (dog) and 5 mg/kg (rat) the plasma levels showed significant
      differences. Moreover, a marked sex difference was to be seen in the plasma
      levels of the rat. The excretion, established only in the dog, showed no
      difference after single or multiple administration. The elimination occurs
      predominantly via the kidneys, and the main urinary elimination product is the
      unchanged clenbuterol. Each of the 8 metabolites is formed only in minor
      quantities. The biotransformation is not altered by long-term administration. The
      differences in the plasma levels that are observed with larger doses can be
      explained by the biological adaptation of the gastrointestinal tract during
      multiple administration.

PMID- 1036939
TI  - [Elevated creatine kinase activity in serum following oral application of a beta2
      mimetic broncholytic drug (NAB 365) (author's transl)].
AB  - In 25 patients with chronic bronchitis it was shown by a study of 9 months'
      duration (3 months before treatment, 6 months under treatment) that after peroral
      application of 4-amino-alpha-[(tert.-butylamino)methyl]-3,5-dichlorobenzyl
      alcohol hydrochloride (clenbuterol, NAB 365) elevations of the activity of
      creatine kinase occur without other recognizable signs and symptoms. The
      isoenzyme of creatine kinase were differentiated by immunological means and
      proved to be of the MM-type in additional 9 patients. The significance of the
      elevations of creatine kinase activity in serum even after peroral intake of
      drugs has been discussed.

PMID- 1036940
TI  - [Biotransformation of diflucortolone valerate in the skin of rat, guinea pig and
      man (author's transl)].
AB  - The biotransformation of 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21
      valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolone valerate, DFV, Nerisona)
      was examined in vitro in the skin of rat and man and in vivo in the skin of
      guinea pigs. In the investigations with rat skin DFV in ethanolic solution (0.1
      mumol) was added and the ester hydrolysis in buffer monitored in relation to the
      incubation time. In the experiments with guinea pigs and with human skin DFV was
      applied topically in the form of a 0.1% W/O emusion employing a dose of 6 mg/cm2
      skin. After the substance which had not penetrated had been recovered by means of
      cotton wool and adhesive film at the end of the period of exposure the portions
      of skin were homogenized, extracted and the extracts separated by thin-layer
      chromatography. DFV is hydrolysed in the skin of rats and guinea pigs with a half
      life of about 30-60 min to diflucortolone 6alpha,9-difluoro-11bets,21-dihydroxy
      16alpha-methyl-1,4-pregnadiene-3,20-dione) and valeric acid. In excised human
      skin degradation of the ester proceeds much more slowly. Even 7 h p. appl. about
      80-90% DFV and only 5-15% DF were identifiable in the skin extract. Despite the
      estremely low absorption rate the slow hydrolysis of DFV in human skin guarantees
      an adequate level of active ingredient in the skin over a long period.

PMID- 1036941
TI  - [Synthesis of Diflucortolon and its esters].

PMID- 1036942
TI  - [Toxicological examination of pure diflucortolone valerate and its formulations
      as ointment, fatty ointment and cream in animal experiments (author's transl)].
AB  - On the basis of absolute DL50 values 6alpha,9-difluor-11beta-hydroxy-16alpha
      methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione (diflucortolone valerate,
      Nerisona) is virtually non-toxic after single oral administration (mouse greater
      than 4 g/kg, rat ca. 3.1 g/kg, dog greater than 1 g/kg). Given s.c. (LD50 mouse
      ca. 180 mg/kg, rat ca. 13 mg/kg) and i.p. (LD50 mouse ca. 450 mg/kg, rat ca. 98
      mg/kg) it is highly active and therefore produces also toxic effects. The
      formulations Nerisona ointment, fatty ointment and cream have proven practically
      non-toxic in rats after single oral gavage (LD50 greater than 33 g/kg). The daily
      s.c. administration over 6 weeks revealed systemic glucocorticoid effects in rats
      at 0.0004 mg/kg and in dogs at 0.04 mg/kg. Similar effects were seen in dogs
      after daily dermal treatment for 13-14 weeks with Nerisona ointment at 100 mg/kg
      body weight. On the skin of rabbits and dogs there were no differences in the
      reaction at the application site between Nerisona ointment, fatty ointment and
      cream and the corresponding ointment, or cream bases by daily dermal
      administration for 28 days. However, the 13-14 week dermal study in dogs with
      Nerisona ointment revealed atrophy of the epidermis at the application site in
      several cases. The daily dermal application of Nerisona ointment during
      organogenetic phases of pregnancy caused embryotoxic effects in rats at 500 mg/kg
      and in rabbits at 50 mg/kg. All of these findings are discusses as well-known
      glucocorticosteroid effects.

PMID- 1036943
TI  - [Percutaneous absorption of diflucortolone valerate in guinea pigs and man
      (author's transl)].
AB  - Percutaneous  absorption of 6alpha,9-difluoro-11beta-hydroxy-16alpha-methyl-21
      valeryloxy-1,4-pregnadiene-3,20-dione (difucortolone valerate, Nerisona) as
      dependent on the base, the concentration in the base and the condition of the
      skin was investigated in man and in guinea pigs. In addition the distribution of
      the corticoid in the stratum corneum, epidermis and corium was determined by
      stripping the skin and by horizontal thin-section technique. 2. In man
      diflucortolone valerate from all of the formulations tested (0.1 and 0.3% cream,
      ointment and fatty ointment) was only absorbed to a slight extent by both the
      intact and the stripped areas of skin on the subjects' backs. In the case of the
      0.1% formulations a total of about 0.2% of the dose was absorbed within 4 h via
      intact skin and about 0.4% via the stripped skin. After application of the 0.3%
      formulations the percutaneous absorption from the ointment, fatty ointment and
      cream were examined separately. This revealed percutaneous absorption within 7 h
      of 1.7% from the ointment, 0.7% from the fatty ointment and 0.5% for the cream by
      combined determination through 1 intact and 1 damaged area of skin. 3.
      Percutaneous absorption via intact skin is slight in the case of the guinea pig
      also. Absorption is accelerated considerably by the removal of the stratum
      corneum, however, and shows a characteristic dependence on the concentration of
      the corticoid in the base. Whereas the corticoid from the 0.03% ointment is
      almost quantitatively absorbed within 7 h, absorption from the 0.5% ointment is
      reduced to about 30%. 4. The absolute concentrations of active ingredient in the
      epidermis are approximately 10(-6) mol/l and drop to approximately 10(-7) mol/l
      in the corium (guinea pig in vivo, man in vitro). An active ingredient flow
      equilibrium (inflow = outflow) is reached in the skin of the guinea pig after
      only 1 h.

PMID- 1036944
TI  - [Pharmacokinetics and biotransformation of diflucortolone valerate in man
      (author's transl)].
AB  - Two male normal subjects were each given 1 mg of 6alpha,9-difluoro-11beta-hydroxy
      16alpha-methyl-21-valeryloxy-1,4-pregnadiene-3,20-dione1,2,4-3H (3H
      diflucortolone valerate, Nerisona) by i.v. injection. The pharmacokinetics and
      biotransformation of the corticoid were examined by measurement of the total
      activity in the blood, plasma, urine and faeces and by thin-layer chromatographic
      analysis of the spectrum of the metabolites in plasma and urine. The compound is
      very rapidly degraded. No more intact ester was identifiable in the plasma 5 min
      after injection while, at the same time, 6alpha,9-difluoro-11beta,21-dihydroxy
      16alpha-methyl-1,4-pregnadiene-3,20-dione (diflucortolone), the product of
      hydrolysis, was present in a concentration of 6-8 ng/ml plasma. The half-life of
      diflucortolone in the plasma was 4-5 h, that of the total 3H-steroids about 9 h.
      80-40% of the 3H-steroids in the plasma were in unconjugated form. Besides
      diflucortolone and two unidentified metabolites chromatographic comparison
      demonstrated the presence of 6alpha,9-difluoro-21-hydroxy-16alpha-methyl-1,4
      pregnadiene-3,11,20-trione (11-keto-diflucortolone) as a further metabolite in
      the plasma. The elimination was rapid and complete: by 24 h after injection
      approximately 56% of the dose had been eliminated with the urine and by 7 days
      after administration 98 and 93% of the dose had been recovered in urine and
      faeces. The ratio of elimination urine to faeces averaged 3:1. Within 48 h after
      the injection about 30% of the dose was eliminated in the form of unconjugated 3H
      steroids, about 20% as 3H-steroid-glucuronides and about 10% as 3H-steroid
      sulphates. Diflucortolone was demonstrable both in the unconjugated form and as
      glucuronide and 11-keto-diflucortolone as glucuronide and as sulphate. A total of
      7 metabolites were characterized in the urine by means of chromatography.

PMID- 1036945
TI  - [Comparative studies in man on the percutaneous absorption of diflucortolone
      valerate, betamethasone-17-valerate, beclomethasone dipropionate and fluocinolone
      acetonide].
AB  - Percutaneous absorption of 6alpha,9-difluor-11beta-hydroxy-16alpha-methyl-21
      valeryloxy-1,4-pregnadience-3,20-dione (diflucortolone valerate, DFV, Nerisona),
      betamethasone 17-valerate (BV), beclomethasone dipropionate (BDP) and
      fluocinolone acetonide (FA) by damaged skin was examined on the backs of 4
      healthy males from whom the stratum corneum had been removed by "stripping". The
      determination of percutaneous absorption was performed on the one hand by a
      method employing radioactive labelled compounds (DFV, BV) and measuring the
      elimination with the urine and faeces and on the other hand by photometric
      determination (DFV, BV, BD, fa) of the corticoid remaining on the skin
      immediately following application and at the end of a 24-h period of exposure.
      Direct measurement of the radioactivity in the urine and faeces revealed that
      percutaneous absorption from a new W/O emulsion takes place up to 2.2+/-0.8% in
      the case of DFV (0.1%) and to at least 12.2+/-3.3% in the case of BV (0.12%)
      within 24 h. The determination of percutaneous absorption via recovery from the
      skin produced the following results for the 4 corticoid preparations examined:
      DFV (14.8+/-4.2%) and BDP (14.0+/-4.3%) approximately equal, BV (23.5+/-4.1%) a
      marked increase and FA (39.2+/-2.4%) the highest level of absorption. This order
      for percutaneous absorption appears to correlate to the frequency of systemic
      side effects.

PMID- 1036946
TI  - [Efficacy of diflucortolone valerate in the vasoconstriction tests].
AB  - The efficacy of a new topical corticosteroid, 6alpha,9-difluor-11beta-hylerate,
      Nerisona), as a 0.1% cream, ointment and fatty ointment was investigated in the
      vasoconstriction test in two series of studies after application to human skin in
      which hyperaemia had been experimentally induced. The diflucortolone valerate W/O
      emulsion proved to be 100 times more effective than fluocortolone in an identical
      base. In a further study diflucortolone valerate as well as in the three
      preparations was compared with nine known corticosteroids or their commercial
      preparations. In the comparison of the preparations only the cream with 0.05%
      betamethasone-17,21-dipropionate was superior to the diflucortolone valerate
      cream. As regards all the other preparations of formulations the new substance
      proved to be more or at least equally effective.

PMID- 1036947
TI  - [Reactivation of phosphorylated acetylcholinesterase (AChE): quaternary salts of
      vinylogous pyridinaldoxims (author's transl)].
AB  - Application of Wittig reaction to 4-pyridinecarboxaldehyde leads to 4-beta
      formylvinylpyridine (62%). The corresponding oxime (4-(2)) can be quaternized
      with alpha,alpha'-bis-(chloromegonin), and with methyliodide one to 4-PAM (4
      (3)). In this case the formal insertion of an ethylenic double bond between the
      pyridinium ring and the aldoxime group decreases the ability to reactivate
      phosphorylated acetylcholinesterase (AChE).

PMID- 1036948
TI  - [Binding of sisomicin and gentamicin to serum proteins (author's transl)].
AB  - The binding of sisomicin and gentamicin to the proteins of human serum was
      investigated by the dialysis method at 37 degrees C. The antibiotic
      concentrations were determined by the disc diffusion assay as well as by
      measurements of the optical rotation of the antibiotics in the buffer solutions.
      Serum was dialyzed against buffer solutions to obtain the standards for the
      antibiotic assay with regard to the electrolytical exchange at dialysis. In
      studies on protein binding of sisomicin and gentamicin no measurable binding to
      human serum proteins could be found, neither in the therapeutically possible
      concentrations nor at higher ones. Therefore a different binding of the two
      antibiotics cannot be the reason of the advantage of sisomicin over gentamicin in
      tests in vivo with animals described in literature nor of its higher activity
      against several bacterial strains of different species tested in the presence of
      serum.

PMID- 1036949
TI  - [Synthesis of a water-soluble orotic acid salt. Short communication. (author's
      transl)].
AB  - Description of the synthesis of thiaminedisulfide-monoorotate, the first salt of
      the orotic acid soluble in water with neutral action.

PMID- 1036950
TI  - The uptake of potassium ions into isolated heart mitochondria in the presence of
      calcium ions and k-strophanthin.
AB  - The conditions of potassium transport were investigated in isolated rabbit hear
      mitochondria. In the presence of 5 to 40 mM potassium chloride there is a rapid
      initial phase of potassium influx of less than 2 min duration in which 65-75% of
      the total K+ uptake occurs. This is followed by a slow phase of K+ uptake of
      about 45 min during which 25 to 35% of the total potassium was taken up. While
      the rapid phase is due to passive diffusion, the slow phase is an active process
      which requires either ATP or respiratory substrates as an energy source. It can
      be totally abolished by 0.5 mM antimycin A. An increase of the calcium
      concentration in the incubation medium to more than 5 X 10(-5)M resulted in an
      inhibition of the energy-dependent uptake of potassium which was directly
      proportional to the calcium level. k-Strophanthin induced a distinct inhibition
      only at very high concentration  (greater than 10(-4)M). The inhibition of
      potassium uptake by 1. 3 or 5 mM calcium chloride was gradually cancelled by
      increasing k-strophanthin concentrations above 10(-8)M. Maximal cancellation was
      found with 10(-5)M of k-strophanthin. This concentration almost completely
      prevented the inhibition by calcium ions. On the other hand, 10(-5)M k
      strophanthin had no inhibitory effect on the energy-dependent uptake of 0.5
      mumoles of calcium chloride or on the oxidative phosphorylation of 0.5 mumoles of
      ADP added to the incubation medium.

PMID- 1036951
TI  - Cardiovascular effects of an antiarrhythmic aminosteroid ORG 6001 in the
      anesthetized pig.
AB  - The hemodynamic effects of 3alpha-amino-5alpha-androstan-2beta-ol-17-one
      hydrochloride (ORG 6001), an aminosteroid possessing antiarrhythmic properties,
      were studied in 14 anesthetized pigs. ORG 6001 was administered i.v. cumulatively
      until a toxic level was reached. Doses less than 20mg/kg had, in spite of the
      negative inotropic properties of ORG 6001, no effect on the pump function of the
      heart, as the afterload was reduced and the filling pressure was not
      significantly altered. After administration of 40 mg/kg A-V conduction was
      depressed and second degree A-V block appeared. This was associated with
      deterioration of the pump function and for 6 of the 14 animals this was fatal. In
      the survivors, the alterations were reversible after cessation of drug
      administration. Since ORG 6001 has been shown to be effective against arrhythmias
      at doses less than 20 mg/kg, though in a different species (dog), it seems likely
      that it can be used safely for antiarrythmic treatment.

PMID- 1036952
TI  - [Acute myocardial infarct and pindolol. Effect of a beta sympatholytic with
      intrinsic sympathomimetic activity on hemodynamics and contractility].
AB  - After acute circumscribed myocardial infarction the effects of the beta
      sympatholytic agent 1-(indol-4-yl-oxy)-3-isopropyl-amino-propan-2-ol (pindolol;
      Visken) on hemodynamics and contractility were examined. Hemodynamic changes
      after application of pindolol are of small extent only. Heart rate shows a rising
      tendency whereas systolic and diastolic aortic pressure decreases only after
      higher doses. Left ventricular end-diastolic pressure (LVEDP) does not change
      remarkably. Cardiac output is reduced by small doses of pindolol and reaches
      starting values again before the administration of higher doses. Changes of the
      contractility parameters (dp/dt)max, t-(dp/dtmax, and PEP in the sense of a beta
      sympatholysis appear only in the lower range of the doses given. Thus maximum
      decrease of contractility is 20% measured at (dp/dt)max, which consequently
      reaches the starting value again. The other contractility parameters change
      accordingly. These typical dose-response relations between pindolol and
      contractility parameters are considered to be due to lacking cardiac depressive
      properties combined with significant so-called positive intrinsic activity. Our
      results show that no contraindication can be derived from the small influence of
      pindolol on contractility in acute myocardial infarction.

PMID- 1036953
TI  - Effects of cinepazide, a new vasoactive substance, on heart and circulation in
      the dog.
AB  - The authors report on the action of a new drug, 1-(pyrrolidinyl-1-carbonyl)
      methyl-4-(3,4,5-trimethoxycinnamoyl)-piperazine-maleate (cinepazide), on the
      heart and systemic and coronary circulation. At doses of 1--3 mg/kg i.v. (n=6),
      systemic blood pressure decreased by 4%, and heart rate increased reflexly by
      8%...

PMID- 1036954
TI  - Influence of cinepazide, a vasoactive substance, on canine coronary circulation
      after acute constriction of the left anterior descending coronary artery.
AB  - The left anterior descending coronary artery was variably constricted
      mechanically in nine dogs. Blood flow in the left anterior descending (LAD) and
      circumflex coronary arteries (CCA), aortic pressure and peripheral, i.e. post
      stenotic coronary pressure were measured. Myocardial perfusion was determined
      from the clearance of radioactive xenon injected at a depth of 7 mm into the
      underperfused area supplied by the LAD artery. The vasoactive drug 1
      (pyrrolidinyl-1-carbonyl)-methyl-4-(3,4,5-tri-methoxycinnamoyl)piperazine-maleate
      (cinepazide) was given at doses of 5-10 mg/kg by i.v. route. 1. Blood flow in the
      LAD was decreased stepwise to 50% of its initial value. There was practically no
      more coronary reserve. After drug injection, diastolic aortic pressure, that
      normally falls, was kept constant by clamping. Heart rate, perfusion pressure,
      post-stenotic pressure, and blood flow and resistance in the LAD showed
      practically no change. In the CCA, blood flow increased significantly (p less
      than 0.005) and flow resistance decreased (p less than 0.001). 133Xe clearance
      showed an increased myocardial perfusion (p less than 0.02) in the territory
      supplied by the LAD artery. 2. The lumen of the LAD was narrowed by 53%, i.e.,
      coronary reserve was decreased. This constriction was followed by no haemodynamic
      reaction. After injection of cinepazide, mean and diastolic aortic pressure (p
      less than 0.02) and post-stenotic coronary pressure (p less than 0.005)
      decreased. Blood flow increased by 41% in the CCA and by 31% in the LAD. Coronary
      resistance in these vessels decreased (p less than 0.001 and 0.005,
      respectively). Here, too, the 133Xe clearance curve showed an increase in
      myocardial perfusion in the territory supplied by the LAD artery (+78%).

PMID- 1036955
TI  - The distribution and excretion of 14C- and 3H-labelled 4-prenyl-1,2-diphenyl-3,5
      pyrazolidinedione (DA 2370) in the rat.
AB  - The distribution and excretion of radioactivity following a single or multiple
      oral administration of 3H-and/or 14C-4-prenyl-1,2-diphenyl-3,5-pyrazolidinedione
      (DA 2370) has been determined in rats. The daily excretion of radioactivity
      following a single administration (3H and 14C) or multiple doses (3H) fell to
      less than 1% of the dose in 4 days. A similar fall was observed at the end of 10
      days continuous administration. The radioactivity in plasma reached a maximum
      between 2 and 4 h after administration of the drug (14C). Tissue levels were
      found to be effectively zero 24 h after administration of the drug for up to 10
      days. The very large amounts of radioactivity lost in bile were found to
      correlate with blood, tissue and faecal levels.

PMID- 1036956
TI  - Acute toxicity of various solvents in the mouse and rat. LD50 of ethanol,
      diethylacetamide, dimethylformamide, dimethylsulfoxide, glycerine, N
      methylpyrrolidone, polyethylene glycol 400, 1,2-propanediol and Tween 20.
AB  - The LD50's of various solvents frequently used in toxicological work to improve
      the solubility of otherwise poorly soluble compounds were determined in the mouse
      and rat. The substances investigated were ethanol, dimethylacetamide,
      dimethylformamide, dimethylsulfoxide, glycerine, N-methylpyrrolidone,
      polyethylene glycol 400, 1,2-propanediol and Tween 20. The substances were
      administered under standardized conditions to groups of 10 animals (5 females, 5
      males) (mice and rats) at doses that supplied at least 3 values lying between the
      LD16 and LD84. The median lethal dose and slope were determined with the aid of
      Finney's programmed probit analysis. The results are tabulated as LD50 ml/kg with
      95% confidence limits. It is recommended that when using these solvents for
      pharmacological and toxicological investigations not more than a quarter of the
      LD50 should be used because otherwise there will be confusion between the deaths
      due to the substance being investigated and those due to the solvent.

PMID- 1036957
TI  - [Influence of an antispastic, analgesic combination on blood pressure, dynamics
      and contractility of the left ventricle in the dog].
AB  - The following cardiovascular parameters were continuously measured in 12 dogs
      anaesthetized with sodium pentobarbital following i.v. application of Baralgin, a
      combination of 1-beta- piperidino-ethoxycarbmethoxy-benzophenone-hydrochloride
      with diphenylpiperidino-ethyl-acetamide-bromomethylate and 2.3-dimethyl-4
      methylamino-1-phenyl-5-pyrazolone-N-methanesulfonic acid: Mean arterial blood
      pressure, left ventricular pressure, dp/dt-value in the left ventricle, the
      parameter (see article), told peripheral resistance, cardiac work, heart rate,
      cardiac output and stroke volume, flow rate in the A. femoralis and the
      repiration volume. In this experimental series dosages of 0.1, 0.25, 0.625 and
      1.56 ml Baralgin/kg i.v. were tested and the subsequent cardiovascular activity
      was recorded for a period of 90 min following application. 1. The mean arterial
      blood pressure remained practically unaltered following low doses of Baralgin
      (0.1 and 0.25 ml/kg i.v.), whereas higher doses (0.625 and 1.56 ml/kg) led to an
      initial drop in blood pressure corresponding to the fall in total resistance. 2.
      The cardiac output rose slightly in correlation with rise in stroke volume. In
      the dosage range of 0.25 ml Baralgin/kg i.v. the rise in cardiac output was
      accentuated by an increase in heart rate. 3. The cardiac work remained relatively
      stable following small Baralgin doses, however, a slight diminution in cardiac
      work due to the fall in blood pressure and decrease in cardiac output, resulted
      from application of 1.56 mg/kg i.v. 4. A slight positive inotropic stimulation of
      the heart became apparent in the initial period following small doses of Baralgin
      (0.1 and 0.25 ml/kg i.v.), higher i.v. dosages caused a marginal reduction in
      cardiac contractility.

PMID- 1036958
TI  - Assessment of Hypervitaminosis D during the first trimester of pregnancy on the
      mouse embryo. Preliminary report.
AB  - The effect of hypervitaminosis were studied in pregnant mice during 0-3 and 4-7
      days of gestation. After pregnancy was determined, mothers received 50 000 I.U.
      of vitamin D2 during the first gestational period. During the first half of the
      first trimester, the vitamin D treatment did not significantly influence maternal
      weight, fetal weight, implantation rate and survival of the embryo. The number of
      mothers with malformed fetuses significantly increased during critical treatment
      periods (from 4-7 days of pregnancy.

PMID- 1036959
TI  - Effect of short- and long-term administrations of some drugs on rat intestinal
      flora. Short communication.
AB  - Two schedules of treatment were adopted for an experimental evaluation of drug
      induced alterations in mid-small intestinal flora of normal rats. Test substances
      were given orally twice daily for 3 days at large doses and once daily for 30
      days at lower doses. Indometacin, benzydamine, phenylbutazone, pheprazone,
      picosulfol, magnesium sulfate, tolbutamide, phenformin, dexamethasone acetate and
      prednisolone acetate were tested. Drug-induced alterations in rat intestinal
      flora resulted more evidently following multiple short-time treatments.

PMID- 1036960
TI  - Antagonism of maximal metrazol seizures in rats and its relevance to an
      experimental classification of antiepileptic drugs.
AB  - The antagonism of various components of maximal Metrazol-seizures (MMS) (i.e.
      tonic hindpaw extension, tonic backward extension of the forepaws, generalized
      clonic seizures and tremors), ataxia and loss of righting reflex-activity have
      been studied in a standardized procedure comparing 41 antiepileptics and related
      compounds. Appropriate analyses (Cluster Analysis and Principal Component
      Analysis) resulted in the distinction of seven clusters which could be considered
      along two continua. A first continuum is characterized by a progressive
      strengthening of loss of righting reflex-inducing properties, a decreasing
      dissociation of ataxia and loss of righting reflex and the disappearance of a
      selective anticonvulsant effect. The second continuum is characterized by an
      increasing relative potency of ataxia-inducing properties, an increasing
      dissociation of ataxia and loss of righting reflex and a decreasing antagonism of
      tremors. Three main types of anticonvulsants could be defined: drugs with a
      complete anti-MMS effect antagonizing both clonic and tonic seizures; drugs
      selectively abolishing tonic seizures, i.e., tonic extension of hind- and
      forepaws; and drugs exclusively blocking tonic hind-paw extension. The
      neurological and clinical significance of these different types of anticonvulsant
      activity has been discussed. Finally, the described modification of the maximal
      Metrazol-seizures test is proposed for routine screening purposes.

PMID- 1036961
TI  - Influence of silymarin on drug metabolizing enzymes in rat and man.
AB  - Male rats weighing 100-130 g were treated orally with a daily dose of 1 X 10 mg
      Legalon (active principle: silymarin)/100 g b.w. daily for 4 or 10 days. 4 and 10
      days after the beginning of the pretreatment a significant increase of the
      activity of the mixed function oxidation system (Cytochrome P-450, aminopyrine
      demethylation, p-nitroanisole demethylation) was observed. No alteration of the
      body weight, the liver wet weight, the microsomal protein content, the cytochrome
      b5 content and the activities of glucose-6-phosphatase (G-6-Pase) and of a
      glucoronidase (4-methylumbelliferone) took place after the Legalon treatment. 4 h
      after the oral administration of 0.5 ml CCl4/kg b.w. the activity of the mixed
      function oxidation system and of the G-6-Pase was markedly decreased. This effect
      could not be prevented by the oral administration of 1 X 10 mg Legalon/100 g b.w.
      6 h prior to CCl4 application. In human subjects the treatment with daily doses
      of 3 X 70 mg Legalon during 28 days had no influence on the metabolism of
      aminopyrine and phenylbutazone. From our results it is concluded that Legalon
      despite its effects in experimental animals has no influence on drug metabolism
      in man, when applied in therapeutic amounts.

PMID- 1036962
TI  - Studies of the kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4
      oestren-3-one-7-3H (norethisterone enanthate) in humans following intramuscular
      injection.
AB  - The kinetics and metabolism of 17 beta-heptanoyl-17 alpha-ethinyl-4-oestren-3-one
      7-3H (7-3H-norethisterone enanthate, NET-En) after i.m. injection in two female
      subjects is described. 177.4 mg and 174.5 mg NET-En were injected. Maximum 3H
      activity in plasma was reached 8 to 14 days after the injection. In terms of NET
      En it amounted to 70-100 mug/100 ml. Maximum NET concentration was reached on the
      4th to 8th day and amounted to about 1 mug/100 ml. After 4 weeks NET
      concentration was still about 0.05 to 0.1 mug/100 ml and even after 6 weeks NET
      was still detectable in plasma. In 14 days the two subjects excreted about 13% of
      the administered dose in the urine and about 15% and 21%, respectively, in the
      faeces. On the basis of a rough calculation, the subjects eliminated about 60%
      and 55% of the radioactivity with urine and faeces within 42 days.

PMID- 1036963
TI  - Experimental evaluation in man of analgesic effects.
AB  - A device operated by compression has been studied in order to define a method of
      measuring analgesic effects. Three analgesics (metamizol, acetylsalicylic acid
      and ketobemidone) and placebo have been tested in man to verify the adequacy of
      this apparatus and its sensitivity.

PMID- 1036964
TI  - A study of the EEG sleep patterns and the sleep and dream experience of a group
      of schizophrenic patients treated with sulpiride.
AB  - The modifications of spontaneous sleep in schizophrenic patients following N
      ethyl-2(2-methoxy-5-sulfamido-benzamidomethyl)-pyrrolidine (sulpiride, Dobren)
      administration are reported in this study. No significant modifications in the
      quantitative distribution of the various sleep phases (LST, SWS, REM) were
      observed, while a significant percent increase of SWS was noted, together with a
      significant decrease in the number of awakenings during the night and an increase
      of the sleep onset time. The patients' own difficulty to fall asleep, however,
      decreased significantly, and also a significant increase of dream recall could be
      observed.

PMID- 1036965
TI  - [The autoradiographic distribution of 3H-spironolactone in whole-body slices of
      the mouse (Short communication)].
AB  - The autoradiographic localisation of H3-spironolactone in whole-body sections of
      mice is shown. The drug is enriched in the liver, bile-ducts and in the content
      of the small intestine, which probably indicates a biliary excretion.

PMID- 1036966
TI  - Vitreoretinal reactions and persistent hyaloid vessels.
AB  - In cases with persistent primary vitreous in full-term infants there were
      vitreoretinal reactions including vitreoretinal anastomoses of blood vessels,
      vitreoretinal strands, traction folds of the retina, avascular retinal areas,
      hypoplasia of retinal blood vessels, rarefaction of retinal ganglion cells, and
      ischaemic structural changes of the retina. New vessel formation on the surface
      of avascular retinal areas was supplied from persistent hyaloid blood vessels.
      This finding may be of some importance in explaining those cases histologically
      resembling classical retrolental fibroplasia with no history of prematurity or
      oxygen treatment.

PMID- 1036967
TI  - Malignant lymphoma of the thyroid.
AB  - Two cases of malignant lymphoma are reported and the clinical features of a
      further 6 cases collected over a 10-year period are presented. The literature is
      reviewed and the treatment, prognosis and relationship to Hashimoto's disease are
      discussed. It is suggested that lymph node biopsy at the time of operation is
      important in confirming the diagnosis and that the prognosis may be more hopeful
      than has previously been suggested.

PMID- 1036968
TI  - Born before their time into this breathing world.

PMID- 1036969
TI  - Some aspects of sexually transmitted disease in Swaziland.
AB  - A survey of sexually transmitted diseases was attempted in Swaziland. Time and
      the terms of reference limited its scope, but much interesting information was
      gathered. Neither the prevalence nor the relative frequency of the different
      diseases in the community could be ascertained, but there was evidence to support
      the local impression that the sexually transmitted diseases present an increasing
      problem in Swaziland. An important problem was that of case finding and two
      aspects of this are stressed: (1) A general lack of knowledge concerning the
      venereal diseases; (2) The large number of men infected by 'casual' girl friends
      who cannot easily be traced, and who form a reservoir of infection in the
      community.

PMID- 1036970
TI  - Circular dichroism studies of some oligosaccharides containing 2-acetamido-2
      deoxy-D-glucopyranose and D-mannopyranose residues.

PMID- 1036971
TI  - Sexually transmitted diseases in Rhodesia. Part II.

PMID- 1036972
TI  - [Results obtained with chemotherapy of ovarian cancer respecting its
      morphological structure (author's transl)].

PMID- 1036973
TI  - [Possibilities of a directed chemotherapy in ovarian cancer (author's transl)].

PMID- 1036974
TI  - [Results obtained with chemotherapy of endometrial cancer (author's transl)].

PMID- 1036975
TI  - [Results obtained with chemotherapy of carcinoma colli uteri (author's transl)].

PMID- 1036976
TI  - [Attempts of the chemotherapy of cancer of the uterine neck (author's transl)].

PMID- 1036977
TI  - [Levels of DNA and RNA in the carcinomatous tissue of the collum uteri before and
      after application of Cytembena (author's transl)].

PMID- 1036978
TI  - [Association of Hashimoto's disease with carcinoma of the thyroid].
AB  - The Authors describe a case, which came under their observation, of
      indifferentiated neoplasia of the thyroid associated with Hashimoto's disease;
      treated surgically by total thyroidectomy, at a distance of over four years it
      did not show signs of recurrence. Consideration is also given to pathogenetic and
      clinical problems, as well as those of surgical therapy, which such a combination
      between autoimmune thyroditis and a neoplastic process may raise.

PMID- 1036979
TI  - Bromocriptine potentiation of gastric acid secretion in cats.
AB  - Bromocriptine administered both orally and intravenously potentiated gastric acid
      secretion in response to submaximal pentagastrin stimulation in cats.
      Bromocriptine did not increase the maximum acid secretion in response to
      pentastrin, not did it stimulate basal acid secretion. Potentiation was observed
      in normal and vagotomized animals which precludes involvement of the vagi in the
      response. The mechanism of action of this compound on the stomach does not appear
      to be mediated through stimulation of dopaminergic receptors as no potentiation
      was observed with dopamine infusions. It is argued that the bromocriptine
      potentiation of gastric acid secretion may be a demonstration of 5
      hydroxytryptamine or alpha-adrenergic antagonism. However, the potentiation
      observed with daily oral bromocriptine treatment had disappeared by the eighth
      day and may correlate with the disappearance of gastric side effects noted in
      patients on bromocriptine  treatment.

PMID- 1036980
TI  - [Blood triiodothyronine values in pregnant women with hypothyroidism, Basedow's
      disease or with normal thyroid function].

PMID- 1036981
TI  - A comparison of drostanolone propionate (Masteril) and nandrolone decanoate (Deca
      durabolin) in the treatment of breast carcinoma.

PMID- 1036982
TI  - [Determination of urinary vanilmandelic acid (VMA) in anxiety patients subjected
      to dental studies following the ingestion of a new drug preparation].

PMID- 1036983
TI  - Studies on shigella isolated in southern Taiwan.
AB  - During 1969, a total of 1,476 fecal and rectal swab specimens was collected from
      children with diarrhea and 249 strains of shigella were isolated. The incidence
      was 16.9%. The serotypes of 249 strains were: Shigella dysenteriae, 1.6% (4
      strains); S. flexneri, 73.1% (182 strains); S. boydii, 3.2 (8 strains) and S.
      sonnei, 22.1% (55 strains). There was no marked difference of the isolation rate
      throughout the whole year. The susceptibility of shigella isolates to
      chemotherapeutic agents were also investigated. The percentage of the strains
      susceptible to gentamicin was 97.2%; to cephaloridine, 93.2%; to kanamycin,
      91.9%; to colistin, 91.6%; to hetacillin, 88.4%; to ampicillin, 82.4% and to
      nalidixic acid, 79.9%. The other tested chemotherapeutic agents were less
      effective.

PMID- 1036984
TI  - Determination of mycelial steroids with the aid of polyene antibiotics. II.
      Quantitative determination of the mycelial steroids of Mucor hiemalis.
AB  - UV absorption spectrum of polyene antibiotics was dramatically altered in the
      presence of steroids. The introduction of a steroid to an aqueous solution of
      polyene antibiotics resulted in a change in the ratio of absorbance of peak 3
      (with shorter wavelength) to peak 1 (with longer wavelength), E3/E1. Interactions
      between 28 steroids and 4 polyene antibiotics were studied and the results
      revealed that the structures of steroids essential for the optimal interaction
      with polyene antibiotics were C-17 side chain, substitution C-3 hydroxyl group,
      intact steroid nucleus and aromatic A-ring. The ratio of E3/E1 was used for the
      determination of steroids in mycelium of Mucor hiemalis and the result was in
      good agreement with that obtained from gas chromatograph. The (-) strain had a
      greater change in the ratio of absorbance, E3/E1, than that of the (+) strain.
      The ratio of absorbance, E3/E1, decreased in the following order: the (-) strain,
      the (-) strain with the addition of the filtrate of (+) strains, the mated
      strains, the (+) with the addition of the filtrate of (-) strain and the (+)
      strain.

PMID- 1036985
TI  - Treatment of Taenia saginata infection with mixture of areca nuts and pumpkin
      seeds.
AB  - In January and February 1974, 32 adults (20 males and 12 females) and a 13-year
      old girl with taeniasis saginata were treated with the mixture of boiled areca
      nuts and pumpkin seeds at Mastoban, Jen-ai District, Nantou County, Taiwan. A
      total of 48 worms including 42 scolices were recovered from 29 cases. Side
      effects were observed in 4 cases including 3 with complaints of dizziness,
      tinnitus, nausea and vomiting, and one with coma and abdominal pain. Mixtures of
      75-150 g areca nuts and 50-100 g pumpkin seeds were judged effective and safe.

PMID- 1036986
TI  - Mycoplasmal pneumonia in Chinese veterans.
AB  - From 1967-1973, a total of 54 strains of Mycoplasma pneumoniae was isolated from
      patients suffering from different acute respiratory diseases, with an average
      positive isolation rate of 4.7%. Most mycoplasmas were isolated from patients
      aged 40-60, and with pneumonia of primary atypical pneumonias. The highest
      frequency of isolation was found in sputum collected 4-8 days after onset of
      illness. Colony formation on PPLO medium usually occurred 7-12 days after
      incubation. Serological tests were methods of choice for diagnosis of mycoplasmal
      pneumonia. In the 6 years period, 163 patients were diagnosed: 74 were positive
      only by metabolic inhibition test (MIT), 55 were positive only by cold
      agglutination test (CAT), and 34 gave positive by both tests. Of the above 2
      tests, the CAT is nonspecific, but the MIT appears to be more sensitive and
      specific. Of the 94 sera positive by MIT, 42 (48.2%) were also positive by CAT;
      of those negative by MIT, 45 of 507 (8.8%) were positive by CAT. Of 45 sera with
      positive mycoplasma isolation, 37 (82.2%) were also positive by MIT, but only 22
      (48.9%) showed the rises of CAT titers. Clinical features of mycoplasmal
      pneumonia were almost similar to those described by the other investigators. The
      chief symptoms were fever, coughs, chills, rales, malaise, sore throat headache
      and chest pain. The sedimentation rate of erythrocytes was accelerated. White
      count was normal in most cases. Both leucocytosis and leucopenia were found in
      10% of the cases. Seasonal variation in incidence of mycoplasmal pneumonia was
      not obvious, however the lowest incidence occurred during summer. A roentgenogram
      of the chest was necessary for diagnosis of mycoplasmal pneumonia, and the lung
      infiltration was mainly located on right side (57.1%), segmentally, and limited
      to one lobe, especially the lower lobe.

PMID- 1036987
TI  - [The current state of CNS prophylaxis with 198 gold colloid and 60 telecobalt in
      juvenile acute leukemias and non-Hodgkin's lymphomas].

PMID- 1036988
TI  - The prevalence of venereal diseases among food and liquor-handlers in public
      places in Kampala, Uganda.

PMID- 1036989
TI  - Missing evidence of a correlation between Hashimoto-thyroiditis and HLA antigens
      [proceedings].

PMID- 1036990
TI  - Distribution of HLA-antigens in Graves' disease and in autonomous adenoma of the
      thyroid [proceedings].

PMID- 1036991
TI  - HLA antigens in Japanese patients with Graves' disease and Hashimoto's disease
      [proceedings].

PMID- 1036992
TI  - [Intra-amniotic phenolsufonphthalein as a test of placental function].

PMID- 1036993
TI  - [Study of the activity of the pulmonary surfactant in determining the threshold
      of the irritating action of industrial poisons].

PMID- 1036994
TI  - [Surfactant system in different methods of artificial respiration].

PMID- 1036995
TI  - Pattern of source of infection of venereal diseases.

PMID- 1036996
TI  - Antithiamine factor in cotton seed (Bombex malabericum)--its isolation and
      characterization.
AB  - 1. The antithiamine factor isolated from cotton seed (Bombex malabericum) was a
      light yellow amophous substance. 2. 1 mg of this antithiamine factor inactivated
      20.5 mug of thiamine hydrochloride. 3. The antithiamine factor was characterized
      as 3,5-dimethoxy salicylic acid.

PMID- 1036997
TI  - Social aspects of venereal disease aboard a U.S. navy destroyer.
AB  - This paper describes the social characteristics of venereal disease patients
      aboard a US Navy destroyer. The research team administered questionnaires to 247
      crew members at the outset of the ship's 7 month-overseas deployment. When the
      ship returned to home port, the research staff gathered demographic and
      occupational information plus disciplinary records, job performance ratings, and
      complete dispensary visit information for the deployment period. The morbidity
      data indicated that 48% of the entire crew experienced at least one case of VD,
      and of these VD patients, 38% had multiple infections. A set of variables that
      best predicted VD incidence was determined by means of multiple regression
      analysis. These variables included disciplinary record, pay grade, division or
      type of job ("blue-collar" versus "white-collar"), and education. Other variables
      that correlated with VD incidence were age, length of service, marital status,
      performance ratings, and verbal aptitude scores.

PMID- 1036998
TI  - Study of rickettsioses in Slovakia. III. Experimental infection of Apodemus
      flavicollis Melch. by rickettsiae of the spotted fever (SF) group isolated in
      Slovakia.
AB  - Experimental studies of infection of Apodemus flavicollis, and for comparison of
      rickettsiaemia in Clethrionomys glareolus and of susceptibility and antibody
      formation in white mice, with rickettsiae of the SF group isolated in Slovakia,
      gave the following results: the species A. flavicollis reacted by the formation
      of antibodies on subcutaneous administration of rickettsiae, strain B, in an
      amount of 10(0.5) EID 50/0.25 ml, whereas the white mouse only in an amount of
      10(2.5). Rickettsiae, strain B, administered in an amount of 10(3.5) EID 50/0.25
      ml subcutaneously to A. flavicollis were found in smears from the liver and
      spleen of the inoculated animals up to the 25th day following infection, on
      detection by the isolation test on chick embryo yolk sacs in the spleen on day 5
      and 7, in lymph nodes on day 7 and in the brain on day 15 following infection; on
      detection by the method of injecting suspension from the organs into the
      haemocoelom of ticks regularly in the spleen and liver up to the 10th day, in the
      brain, kidney and lymph nodes regularly up to the 15th and irregularly in the
      lungs also up to the 15th day, then regularly in the testes up to the 5th day and
      in the heart, blood and peritoneum up to the 3rd day after infection.

PMID- 1036999
TI  - Bromocriptine in Parkinsonism: long-term treatment, dose response, and comparison
      with levodopa.
AB  - Thirty-seven patients with Parkinsonism were treated with bromocriptine 2.5-300
      mg daily. Bromocriptine, alone or combined with levodopa, caused a 20-30%
      reduction in disability scores in 11 patients treated for one year. Tolerance did
      not develop during this period. Bromocriptine treatment was not of value in six
      patients who had previously not responded or who had lost their response to
      levodopa. However, in four of five patients with response swings on levodopa due
      to rapid changes in plasma dopa levels, the addition of bromocriptine caused a
      more stable response. Dose response curves to bromocriptine 12.5, 25, 50, and 100
      mg and to levodopa 250, 500, 1000, and 2000 mg were studied in seven patients.
      Levodopa 2 g had a greater therapeutic effect and caused a greater rise in plasma
      growth hormone concentration than bromocriptine 100 mg. Levodopa caused emesis
      more commonly and hallucinations less commonly than bromocriptine. Bromocriptine
      appears to be a less potent stimulant than dopamine, and has both pre- and post
      synaptic effects. Metoclopramide 60 mg oral was given 30 minutes before
      bromocriptine or levodopa to establish whether this caused dopamine-receptor
      blockade. Metoclopramide acted as a competitive antagonist to the anti
      Parkinsonism and growth hormone effect of both drugs and in individual cases
      prevented emesis and hallucinations. The fall in blood pressure due to
      bromocriptine or levodopa was not antagonised by metoclopramide. Central and
      peripheral vascular dopamine receptors may be different in nature.

PMID- 1037000
TI  - Sclerosing spinal pachymeningitis. A complication of intrathecal administration
      of Depo-Medrol for multiple sclerosis.
AB  - Reported complications of intrathecal steroid therapy include aseptic meningitis,
      infectious meningitis, and arachnoiditis. We report a case of sclerosing spinal
      pachymeningitis complicating the attempted intrathecal administration of Depo
      Medrol for multiple sclerosis. The lesion is characterised by concentric laminar
      proliferation of neomembranes within the subdural space of the entire spinal cord
      and cauda equina, resulting from repeated episodes of injury and repair to the
      spinal dura mater by Depo-Medrol. There is clinical and laboratory evidence that
      Depo-Medrol produces meningeal irritation and that the vehicle is the necrotising
      fraction.

PMID- 1037001
TI  - Accumulation of 57Co-poly-L-lysine by tumors: an effect of the tumor electrical
      charge.

PMID- 1037002
TI  - New neonatal problems of blood coagulation and fibrinolysis. II. Thromboplastic
      effect of amniotic fluid and its relation to lung maturity.
AB  - Pulmonary hyaline membrane disease in newborn infants is considered an
      abnormality in the alveolar lining layer. Quantitative analysis of this
      surfactant is necessary for the intrauterine diagnosis of lung maturity of the
      fetus. The presence of surfactant in amniotic fluid has been demonstrated by the
      shaking method [1]. But it is also well known that amniotic fluid has a
      thromboplastic effect [3,6]. In order to compare the correlation between the
      shaking method and the thromboplastic effect of the amniotic fluid,
      recalcification time and partial thromboplastin time were measured with and
      without amniotic fluid using an aggregation-meter. In each of 15 cases, a
      shortening of these times was recorded after the addition of amniotic fluid after
      the 30th week of pregnancy. In all cases the addition of amniotic fluid resulting
      in shortening these times. Surfactant seems to have enhancing effect on the
      coagulation. These results demonstrate the presence of surfactant in amniotic
      fluid in agreement with the results of the shaking method. Although these methods
      are of limited utility as quantitative assays for surfactant, they are of
      sufficient accuracy and of great value for clinical diagnosis.

PMID- 1037003
TI  - Prenatal prediction of respiratory distress syndrome. Measurement of surface
      properties and Lecithin/Sphingomyelin ratio in human amniotic fluid.
AB  - 118 samples of amniotic fluid were taken from 102 patients in the 25th to the
      43th week of pregnancy by amniotomy or by transabdominal amniocentesis. 76
      samples were obtained from patients with normal pregnancies without evidence for
      either induction or retardation of lung maturity; they served to establish normal
      values. In 37 cases samples were taken within 72 hours prior to delivery, the
      decisive period for the prediction of a respiratory distress syndrome. In seven
      cases a respiratory distress syndrome occured which was diagnosed by an
      independent pediatrician. The following tests were performed for all samples: 1.
      Surface tension was measured biomechanically using the Wilhelmy balance and a
      surface tension area diagram (Fig. 1) was made: A platimum plate is immersed into
      the liquid placed in the trough; the surface tension is measured via a
      transducer. The surface film of th liquid to be studied is compressed cyclically
      from an initial area of 100% to 20% by a moveable barrier and is expanded
      afterward. Platinum plate and barrier are connected to an X-Y recorder. The
      surface tension area diagrams are interpreted on the basis of the following
      criteria: see article 2. The determination of the L/S ratio (simultaneous
      comparison with the standard method): The method of GLUCK as modified by
      BORER(planimetric interpretation of the the spots) was employed. Both methods
      produced normal values. For the biomechanical measurements a classification into
      three groups was made (25th-30th, 31st-35th, 36th-43rd week of pregnancy)
      (Tab.I);the L/S ratio showed the usual steep increase from the 36th week of
      pregnancy onwards. In cases with RDS (Tab.II) surface tension-area-diagrams show
      high values for gamma max and a slight decrease in surface tension on compression
      (high gamma min values); the stability index is low, the hysteresis is reduced.
      Fig. 3. Up to the 34th week of pregnancy the 2:1L/S ratio assumed as the
      threshold for a sufficient surfactant concentration does not permit a clear
      interpretation; in subsequent weeks all cases fail to coincide with the normal
      pattern of distribution (Fig.2). Both the L/S ratio and the criteria of the
      surface tension area diagrams show significant differences in cases with and
      without RDS. The prognostic validity of both methods was tested for the
      probability of predicting occurrence of RDS, probability of RDS occurence and
      probability of non-occurrence of FDS. The prognostic value seems equal to the L/S
      Ratio.

PMID- 1037004
TI  - Influence of molecular variations of ionophore and lipid on the selective ion
      permeability of membranes: I. Tetranactin and the methylation of nonactin-type
      carriers.
AB  - The manner in which molecular structure of the carrier and the lipid composition
      of the membrane modulate the membrane selectivity among monovalent cations has
      been investigated for nonactin, trinactin, and tetranactin, which differ only in
      their degrees of methylation, and for membranes made of two lipids, phosphatidyl
      ethanolamine and glyceryl dioleate, in which "equilibrium" and "kinetic" aspects
      of permeation, respectively, are emphasized. Bilayer permeability ratios for Li,
      Na, K, Rb, Cs, Tl,and NH4 have been characterized and resolved into "equilibrium"
      and "kinetic" components using a model for carrier-mediated membrane transport
      which includes both a trapezoid energy barrier for translocation of the complex
      across the membrane interior and a potential-dependence of the loading and
      unloading of ions at the membrane-solution interfaces. The bilayer permeability
      properties due to tetranactin have been characterized in each of these lipids and
      found not only to be regular but to be systematically related to those of the
      less methylated homologues, trinactin and nonactin. This analysis has led to the
      following conclusions: (1) The change in lipid composition alters the relative
      contributions of "kinetic" vs. "equilibrium" components to the observed carrier
      mediated selectivity. (2) Increased methylation of the carrier increases the
      contribution of the "kinetic" component to the selectivity relative to that of
      the "equilibrium" component and additionally alters the "equilibrium component
      sufficiently that an inversion of Cs--Na selectivity occurs between trinactin and
      tetranactin. (3) For all ions and carriers examined, the "reaction plane" for ion
      carrier complexation and the width for the "diffusion barrier can be represented
      by the same two parameters, independent of the ion or carrier, so that in all
      cases the complexation reaction senses 10% of the applied potential and the
      plateau of the "diffusion barrier" extends across 70% of the membrane interior.

PMID- 1037005
TI  - Tonsillectomy: an excision biopsy.

PMID- 1037006
TI  - [Surface concentration of pulmonary surfactant in the normal alveoli of the
      adult].

PMID- 1037007
TI  - [Prepared infant food and diet for infants and young children in the GDR].

PMID- 1037008
TI  - [Clinical aspects, diagnosis and treatment of meningitis in the acute period of
      cranio-cerebral injury].

PMID- 1037009
TI  - [Efficacy of antibacterial therapy in patients with various forms of dysentery].

PMID- 1037010
TI  - [Evaluation of soy milk in early infant nutrition in expectation of the onset of
      lactation].

PMID- 1037011
TI  - [Behavior of erythrocyte resistance to oxidative peroxidation using perhydrol in
      a group of premature infants fed with a new humanized milk formula].

PMID- 1037012
TI  - [Clinical findings on the use of milk in liquid form].

PMID- 1037013
TI  - [Use of a new humanized powdered milk in premature and low birth weight infants].

PMID- 1037014
TI  - [Presence of anionic detergent residues in infant milk powder samples].

PMID- 1037015
TI  - [Cytological changes in the csf caused by inthathecal administration of
      methotrexate. II. Studies on a case of neuroblastoma with cerebellar symptoms in
      a child].
AB  - A case of an olfactory neuroblastoma of a 5 years old child is reported. The
      tumour propagated into the intracranial space and produced cerebellar symptoms.
      Features of the neuroblastic cells, found in the cerebrospinal fluid and their
      alterations as an effect of the intrathecal therapy with Mathotrexat are
      analysed. Authors emphasize the differences of alterations of leukaemic and
      neuroblastic cells called into being by the Methotrexat therapy.

PMID- 1037016
TI  - Relationship between experimental results in mammals and man. II. Cytogenetic
      analysis of bone-marrow cells after treatment of cytembena and cyclophosphamide-
      cytembena combination.
AB  - Cytogenetic analysis and the micronucleus test of bone-marrow cells was used to
      study the possible extrapolation of results from experimental animals to man.
      Cytembena was given i.p. in doses of 5, 10, 20, 40 and 80 mg/kg body wt. to
      Wistar rats and in doses of 20, 40 and 80 mg/kg body wt. to ICR mice and to
      Chinese hamsters. Five patients with various types of malignancy, so far
      medically untreated, received 20 mg Cytembena/kg body wt i.v. A combination of
      Cytembena and cylophosphamide was applied i.p. in single equal doses 1 : 1 of
      5,10, 20, and 40 mg/kg body wt to ICR mice, Chinese hamsters and Wistar rats.
      Patients were given i.v. 20 mg Cytembena and 20 mg cyclophosphamide/kg body wt.
      Bone-marrow cells were examined 24 h after the administration. The frequency of
      abnormal metaphases and chromosomal breaks after Cytembena treatment was low;
      nonetheless, the indicated dose-effect relationship was found in all the rodents
      used. The frequency of chromosomal breaks was 2--3 times higher in rodents in
      comparison with man, after treatment with a dose of 20 mg Cytembena/kg body wt.
      Highest frequencies of induced aberrations were found in mice. The rodents
      appeared to be 3--4 times more sensitive to the induction of chromosomal breaks
      and abnormal metaphases than man, after a dose of 20 mg Cytembena and 20 mg
      cyclophosphamide/kg body wt. The micronucleus test may be regarded as a screening
      method for assessing mutagenic activity of chemical compounds. Chromosomal
      analysis and the micronucleus test were about equally convincing in detecting
      mutagenic effects even with the lowest doses of drugs used. However, the dose
      effect relationship was more pronounced in chromosomal aberrations than in the
      micronucleus test.

PMID- 1037017
TI  - [The value of cytological screening for neoplasms in young women].
AB  - The question of the incidence of positive or suspect cervical cytology-tests in
      young women of 30 years or less of age out of a total of 54,604 cervical cytology
      tests is discussed. The results of clinical, cytological, and histological follow
      up are reported. According to our experiences that 158 smears of group Pap. III
      and 99 smears of group of Pap IV and V were found in young women of 30 years or
      less of age this group of patients should not be excluded from consecutive
      cervical cytology-tests or national health-screening programs.

PMID- 1037018
TI  - [Adeno-epidermoid carcinoma of the cervix. An opinion on the so-called cervical
      adenocancroid].
AB  - The so-called adenocancroid of the cervix represents a relative rare type of
      tumors. The diverse morphological criterions are shown on hand of 10 personel
      observations and are distinguished between forms of combination and collision.
      The histological findings of these epithelial mixforms motify a closer occupation
      with the formal genesis of this cervical carcinoma. In the formal genesis of the
      cervical carcinoma. In the formal genesis of carcinoma of the cervix, a decisive
      role is being played by the proliferation of differentiated intermitotic cells
      (reserve cells) in the course of indirect metaplasia. Consequently the majority
      of carcinoma of the cervix, are not squamous-cell-carcinoma, but bipotent-cell
      carcinoma. The bipotent qualities of these cells are also maintained in malignant
      degeneration and enable in rare cases a secondary differentiation running in two
      different directions. The confusing denotation "adenocancroid" should be replaced
      by the definition "adeno-epidermoid-carcinoma of the cervix".

PMID- 1037019
TI  - Time lapse cinematographic demonstration of humoral and cell mediated immunity in
      squamous cell carcinoma of the lung.
AB  - Out of 42 attempts in one case a cell line derived from biopsy material of a
      squamous cell carcinoma of the lung has been established. Tumor-associated
      antigen could be demonstrated by indreict immunofluorescence. The effect of
      allogeneic cytotoxic antibodies, absorbed with normal human lung and sera, on the
      target cells is shown. Blood lymphocytes obtained from patients with squamous
      cell carcinoma of the lung proved to be cytotoxic against this cell line. The
      cell to cell interactions of this phenomenon and the effect of cytotoxic
      antibodies are shown by time lapse cinematography.

PMID- 1037020
TI  - Intrathecal hydrocortisone in the treatment of tuberculous meningitis
      (preliminary report).

PMID- 1037021
TI  - Serum cholesterol levels of Seventh-day Adventists.
AB  - Serum cholesterol levels and dietary habits were surveyed in 27 male and 34
      female Seventh-day Adventist. All subjects studied were lacto-ovo-vegetarians and
      a few consumed some meat products. Their serum cholesterol levels, significantly
      lower than those of the United States general population, showed no sex
      difference but increased with age and were higher in overweight males. Their
      levels, however, were much higher than those of true vegetarians which was most
      likely attributable to their consumption, even though to a limited acount, of
      dairy foods.

PMID- 1037022
TI  - [Changes in surfactant during preservation of isolated cardiopulmonary
      preparations].

PMID- 1037023
TI  - [Diffuse toxic goiter in children].

PMID- 1037024
TI  - Statistical analysis of the 24 hour blood pressure using pressure frequency
      histograms.

PMID- 1037025
TI  - Infant milk powder feeds compared on a common basis.

PMID- 1037026
TI  - [Evaluation of the fibrous-emphysematous changes in pulmonary tuberculosis
      according to clinico-roentgeno-morphological comparisons and the state of the
      surfactant].

PMID- 1037027
TI  - [Changes in the viability of mammalian cells under the influence of an inhibitor
      of DNA synthesis exposed to single and fractionated radiation doses].

PMID- 1037028
TI  - [Kinetic features of restoration of a population of stem cells in a two-component
      model].

PMID- 1037029
TI  - [Effect of exogenous interferon on the viability of SOTs cells].

PMID- 1037030
TI  - [Milk-borne outbreak of tick-borne encephalitis in Olsztyn Province].

PMID- 1037031
TI  - [Influence of genetic factors, of ulcerogenic drugs and of a sound disease on
      both the incidence and characteristics of peptic ulcer].

PMID- 1037032
TI  - [Stomach ulcer. Physiologenetic aspects and therapy with special reference to
      carbenoxolone].

PMID- 1037033
TI  - [Various metabolic disorders in uremia. Physiopathology of anomalous glycide,
      protein and lipid metabolism. Various prospects for a therapeutic regimen].

PMID- 1037034
TI  - Imported milk: a threat to health?

PMID- 1037035
TI  - [Hereditary form of toxic goiter].

PMID- 1037036
TI  - Effect of prolactin and the anit-prolactin bromocriptin on the testosterone
      uptake and metabolism in androgen-sensitive and insensitive canine organs.
AB  - Prolactin promotes the growth and function of the prostate in low doses, whereas
      high doses or previous castration reduce this effect. The antiprolactin
      bromocriptin should reverse the prolactin action. In the castrated dog the
      highest accumulation of H3-testosterone given i.v. occurred in the prostate as
      compared with muscle, urethra, penis, liver and kidney. Prolactin pretreatment
      increased the radiosteroid uptake only in the liver. Converseley, bromocriptin
      suppressed the tracer incorporation into the liver, but increased prostatic
      accumulation. The highest testerone reduction occurred in the prostate of the
      untreated castrated dogs as compared with other organs. Prolactin suppressed 5
      alpha -dihydrotestosterone formation but otherwise did not significantly
      influence testosterone turnover. Bromocriptin, however, stimulated
      dihydrotestosterone formation in the prostate and caused complete inhibition of
      hepatic testosterone reduction.

PMID- 1037037
TI  - [Cholegraphic studies performed using a new hepatotropic contrast substance].

PMID- 1037038
TI  - [Products of the interaction of ethazole with mustard oils].
AB  - Synthesized were nonsymmetrical N1N1--replaced products of thiocarbamide
      containing residual alkyl- and arylsinapic oils and the sulfonamide ethasole, in
      order to study their pharmacologic activity. The synthesis was performed through
      heating the components up to the point of weak boiling in an ethanol medium. The
      obtained nine new N1N1--thiocarbamide products were identified in terms of their
      melting point and sulfur analysis. Tentative microbiologic testing showed that
      the newly obtained compounds produce bacteriostatic and bactericidal effects.

PMID- 1037039
TI  - [Determination of the concentration of copper, lead, cadmium and zinc in milk by
      atomic absorption spectrophotometry].
AB  - Developed was an atom-absorption method for determining microconcentrations of
      copper, lead, cadmium, and zink in milk originating from various regions of this
      country. The study was carried out by means of an atom-absorption
      spectrophotometer AA-5. Established were the optimal conditions for determining
      the trace elements reaching the following values of susceptibility: for copper-
      0.04; for lead--0.11; for cadmium--0.001; and for zinc--0.009 mg/cu.cm, with an
      allowance of 5%. The results obtained are discussed and statistically processed.
      Literature data are comparatively studied reflecting the amounts of these
      elements in milk as found in this country and abroad. Such data will be made use
      of in the elaboration of Bulgarian reference tables necessary for establishing
      various regimes and norms concerning the food products offered in children
      creches, hospitals, canteens, etc.

PMID- 1037040
TI  - [Results of clinical study of cytembena].

PMID- 1037041
TI  - [Characteristics of the tonus and reactivity of cerebral vessels in diffuse toxic
      goiter].

PMID- 1037042
TI  - [Increasing qualifications of medical workers by training in a dermatology
      venerology clinic].

PMID- 1037043
TI  - [Improvement in the work of physicians of skin and venereal disease
      dispensaries].

PMID- 1037044
TI  - [Arthroscopy in injuries meniscus].

PMID- 1037045
TI  - [Problem in the etiology of meniscus cysts].

PMID- 1037046
TI  - [Late results of meniscectomy].

PMID- 1037047
TI  - Purification of Aspergillus niger alpha-amylase.

PMID- 1037048
TI  - Production of Candida utilis on slop by-product of fermentation industries.
AB  - The slop (vinas) liquor, a major by-product a alcohol fermentation industries,
      has been used as growth medium for production of the torula yeast, Candida
      utilis. Supplementation of the slop with 0.2% ammonium sulphate and 1% to 5%
      molasses improved the cell yield significantly. The crude slop gave better
      results than the diluted or centrifuged liquors. Under optimal conditions, more
      than 15 grams of yeast were obtained on dry weight basis. The application
      feasibility of these results is presented.

PMID- 1037049
TI  - Effect of some pesticides on the efficiency of the inoculated Rhizobium
      associated with broad bean plants.
AB  - The effect of some pesticides on the efficiency of the inoculated rhizobium in
      broad bean plants (Vicia faba) was studied in greenhouse experiments. Different
      pesticides were used in this work, including insecticides, herbicides,
      nematocides, and a molecide in different concentrations. The study revealed the
      following conclusions. Application of insecticides in different concentrations
      generally affected the formation of efficient nodules on the root system of broad
      bean plants. The inhibitory effect was also reflected to some extent on the dry
      weight of the plants and total nitrogen fixed by rhizobia in association with the
      mentioned plants. Birlane (insecticide) was found to be the most inhibitory
      insecticide on the inoculated rhizobium. Some of the insecticides, such as Temik
      and Dursban, at lower concentration were found to be a stimulant to symbiotic N
      fixation, giving higher amounts of nitrogen fixed in the macrosymbiont.

PMID- 1037050
TI  - Possible role of solar radiation on the viability of some air fungi in Egypt.
AB  - The high occurrence of Alternaria humicola and the moderate occurrence of
      Stemphylium verruculosum, Rhizopus nigricans, and Epicoccum nigrum in the air of
      Egypt could be correlated to their apparent resistance to solar radiation.
      Cladosporium herbarum, Aspergillus niger, and Penicillium oxalicum, although
      highly occurring, were light-sensitive. The miniumum solar radiation in November,
      coupled with the highest total fungal catch, dominated by Cladosporium herbarum,
      reveals the importance of solar radiation as a factor with direct effect on the
      air fungal population.

PMID- 1037051
TI  - Airborn bacteria in the atmosphere of Kuwait.

PMID- 1037052
TI  - Actinomycetes in the desert of Kuwait.
AB  - The distribution of actinomycetes in two desert localities in Kuwait was
      investigated. The genus Streptomyces was dominant in the two studied localities.
      Attempts to classify this genus in groups and species were made. Species
      producing straight or wavy spore chains were dominating in the two localities.
      Species producing oval spores and smooth spore surfaces were widely distributed.
      The most frequent is the cinereus series. Streptomyces aburaviensis and S.
      wedmorensis were more frequent in Cyperus locality, while S. calvus was the
      dominant one in Rhanterium locality. Each locality was characterized by different
      groups and species.

PMID- 1037053
TI  - Volatile and gaseous exudates of either germinating seeds or roots of okra plant
      in relation to okra wilt disease, caused by some Fusarium species.

PMID- 1037054
TI  - Simple method for carbon determination in microbiological experiments.
AB  - A wet combustion method for the carbon determination was developed. It has been
      proved that the method can be successfully used for the determination of
      biochemical changes in microbe cultures, the soil, in composts, in farmyard
      manures etc. The samples are combusted in evacuated flasks by means of chromic
      sulphuric mixture, and the CO(2) evolved is determined interferometrically.

PMID- 1037055
TI  - The effect of some organic substances on the mycelium of the fungus Ustilago nuda
      (Jens.) Rostr.
AB  - Research was performed for studying the effect of some organic compounds,
      considered by many authors as the products ob barley seed metabolism generated
      after anaerobic seed treatment, on the mycelium of the fungus Ustilago nuda
      (Jens.) Rostr. The author examined the effectiveness of ethylacohol,
      acetaldehyde, acetic acid, succinic acid, lactic acid, and hydroquinone in
      concentrations from 1 M to 10(-6) M, and the effectiveness of extracts from
      disinfected seeds in doses from 10 g to 0.001 g/l. The effect of the mentioned
      solutions was examined as exerted on the growth of dicaryotic mycelium and on the
      growth of the haploid promycelium of the fungus. The dicaryotic mycelium of
      Ustilago nuda (Jens.) Rostr. was cultivated on potato agar with benzoic acid. The
      presence of the acid prevents mitosis, and the chlamydospores germinate on the
      nutritive medium with two fibres having binuclear cells. The haploid promycelium
      was cultivated  on potato agar; chlamydospores germinated with one four-cell
      fibre, and individual cells are mononuclear and haploid. Only later, a dicarytic
      mycelium is created in a complex process. In all the substances used, the
      concentration of 1 M was found to stop further growth of mycelium. The
      concentration of 10(-1) M of acetic acid and hydroquinone also stopped growth,
      the same concentration of acetaldehyde, lactic acid, succinic acid, ethylacohol
      stimulated mycelium growth in comparison with the control. The concentration of
      10(-6) M stimulated mycelium growth in a majority of cases. Extracts from
      disinfected seeds did not influence mycelium growth significantly in all cases in
      comparison with the control. The results were similar in the two types of
      mycelium.

PMID- 1037056
TI  - [Relations within genus Cryptococcus (Sanfelice) Vuillemin].
AB  - A collection of 49 Cryptococcus strains was studied by means of 62 tests, which
      emphasized morphological, physiological and biochemical properties. The
      experimental results were subjected to computer analysis using matching
      coefficient and taxanomic distance. Cluster analysis were carried out using
      average linkage method. Two clusters and one individual strain were formed, the
      first cluster represented the genus Cryptococcus, the second cluster and the
      individual strain did not belong to this genus. The cluster of the genus
      Cryptococcus was divided into five phenons: Laurentii Neoformans, Albidus,
      Terreus and Aerius. The belonging of strains to these phenons is discussed
      comparing the results with those of GC% content in DNA, of the production of
      coenzyme Q and many other. The quick identification phenons was suggested.

PMID- 1037057
TI  - Effect of phosphate fertilization and seed inoculation with ""Okadin'' at high
      rate on yield of broadbean and lentil.
AB  - The effect of phosphate fertilization and seed inoculation with ""Okadin''
      preperation of rhizobia strains on the yield of broadbean and lentil was tested
      in field experiments during the seasons 1969 to 1972 in the farm of Faculty of
      Agriculture, Assiut University. Superphosphate was added at the rate of 0, 50,
      100, or 200 kg/fa., and ""Okadin'' preparation, specific for the kind of legume
      planted, was applied to the seeds at 10 times the recommended rate. Application
      of superphosphate at any of the tested rates did not significantly affect total
      yield obtained, seeds yield, or the nitrogen content of seeds of lentil or
      braodbean. Seed inoculation with Okadin showed no significant effect on the yield
      of broadbean, but resulted in significant reduction in the yield of lentil seeds
      in the two seasons of the experiment.

PMID- 1037058
TI  - The lack of detectable immune complexes in rat anaphylaxis.
AB  - Attempts were made to detect soluble immune complexes (IC) in sera of rats
      submitted to anaphylactic shock 12 days following BPV plus antigen treatment, and
      their in vitro formation following the addition of specific antigens to sera or
      heparinized platelet rich plasma of sensitized rats. We failed to detect ICs or
      IC formation by studying Hageman factor activation and platelet aggregation or by
      using a very sensitive radio-assay of ICs. It is established that the
      anaphylactic activation of Hageman factor as well as the aggregation of platelets
      are not mediated by immune complexes, therefore, other explanations must be
      found.

PMID- 1037059
TI  - Clinical significance of the house dust mite (Dermatophagoides pteronyssinus) in
      asthmatic children in Japan.
AB  - Clinical studies were conducted to evaluate the role of the house dust mite.
      Dermatophagoides pteronyssinus, as an allergen in children's asthma in Japan.
      Skin testing and Prausnitz-Kustner type skin testing showed good correlations
      between the allergenicity of house dust and the mite. A positive Prausnitz
      Kustner type skin reaction to house dust was neutralized by a mite extract.
      Radioallergosorbent test showed good correlation between house dust and the mite
      (r=0.687). The mite exhibited in vitro inhibition of radioallergosorbent test to
      house dust. The inhalation provocation test resulted in an acute respiratory
      attack in one of the patients. These results suggest that the house dust mite is
      an important allergen in asthmatic children in Japan.

PMID- 1037060
TI  - Inheritance of asthma in families and its linkage to HLA haplotypes.
AB  - Four families in which asthma occurred in more than three members, and in which
      there were at least three children, were studied in terms of clinical symptoms,
      serum IgE levels determined by RIST and RAST, and HLA haplotypes. No association
      between clinical asthma and serum IgE level was found, but a close association
      between asthma and a particular HLA haplotype in a family was demonstrated. It
      was therefore postulated that a disease susceptibility gene closely linked to an
      HLA gene complex may play a role in the development of asthma.

PMID- 1037061
TI  - [Immediate hypersensitivity to tetracosapeptide (proceedings)].

PMID- 1037063
TI  - [Lymphocyte culture and acupuncture (Proceedings)].

PMID- 1037062
TI  - [Correlation between specific IgE, skin tests and clinical recall of allergens
      during asthma and equivalent respiratory diseases (proceedings)].

PMID- 1037064
TI  - [The unchecked course of the asthmatic child (proceedings)].

PMID- 1037065
TI  - [Asthma and IgA deficiency (Proceedings)].

PMID- 1037066
TI  - [Circadian variations in bronchial sensitivity to house dust in four allergic
      asthma cases (Proceedings)].

PMID- 1037067
TI  - Comparative study of skin and respiratory tests of house dust, mites and human
      squamous epithelial cells in skin respiratory atopy (Proceedings).

PMID- 1037068
TI  - [Provocation by way of the nasal passage in spasmodic rhinitis using nasal
      pressure (Proceedings)].

PMID- 1037069
TI  - Why a meniscectomy fails.
AB  - The clinical and roentgenological data on 30 patients with unsatisfactory
      recovery or recurrent symptoms after meniscectomy were analysed. The meniscectomy
      was regarded as having been the wrong choice of therapy in four patients and as
      ineffective therapy in 11. In 10 patients other knee lesions dominated
      postoperatively, in three the recovery was delayed for no obvious reason but the
      symptoms slowly disappeared, and in the remaining two patients a degenerative
      osteoarthritis developing some time after the meniscectomy was regarded as the
      cause of the recurring symptoms. We conclude that with an optimal clinical and
      arthrographic analysis and with careful operative tecnique as many as 17
      arthrotomies (out of 30 primary and 13 reoperations) in the material presented
      could have been avoided.

PMID- 1037070
TI  - Use of chestnut in the feeding of infants allergic to cow's milk or intolerant to
      lactose.
AB  - The aminoacid contents of native chestnut and its powdered form were studied. It
      was found that it has low cystine and methionine contents but if it is
      supplemented accordingly, the chestnut pulp can well be used for infant feeding.
      More than 50 infants were fed with chestnuts, and only in two cases was there
      intolerance. The aminoacid content of supplemented chestnut formula was lower
      than that of cow's milk and soy bean, but equal to that of human milk and as its
      essential aminoacid ratio was high, the infant's development was normal. Chestnut
      pulp is recommended as an alternative to soybean in the treatment of lactose
      intolerance and cow's milk allergy.

PMID- 1037071
TI  - The place of total thyroidectomy in the management of 909 patients with thyroid
      disease.
AB  - An analytic review of 909 total thyroidectomies reveals complications and
      sequelae comparable to those that follow subtotal operations for Graves' disease,
      nodular goiter, and chronic thyroiditis. It is suggested that when surgery is
      indicated for the management of these diseases, nothing less than total
      thyroidectomy should be performed because of the important additional advantages
      obtained with this operation.

PMID- 1037072
TI  - [Comparison of results obtained from two tests to determine spermatozoid
      penetration of cervical mucus].

PMID- 1037073
TI  - Medicine by satellite telephone--a new breakthrough.

PMID- 1037074
TI  - [Surfactants and lipid metabolism].

PMID- 1037075
TI  - [Gougerot-Sjogren syndrome and Hasimoto's thyroiditis].

PMID- 1037076
TI  - [Influence of heated linseed oil on reproduction in the female rat and on the
      composition of hepatic lipids in young rats].
AB  - During gestation and lactation, six month old female Wistar rats were fed diets
      containing 10 p. 100 by weight of various vegetable oils; thermopolymerized
      linseed oil at 275 degrees C for 12 hours under nitrogen atmosphere (group T),
      oxidized linseed oil at 200 degrees C for 100 hours under air atmosphere (group
      O). The two oils contain respectively 11,5 and 1,1 p. 100 of cyclic monomers (18
      C). Control groups were fed either fresh linseed oil or fresh peanut oil under
      the same conditions. In group T, most of the newborn rats die at birth or during
      the first three days of life; none of them survive 13 days after birth. In group
      O, mortality of youngs is not so high but is still significantly higher than in
      control groups. Moreover, dead young rats of group T have heavier livers and
      higher lipid content in the organ. Cyclic monomers were detected in liver fatty
      acids. In surviving young rats of group O,the body growth during lactation is
      significantly slower than in control animals. Young rats of group O were
      sacrificed at the age of 14 days. Liver weight and lipid content of the organ are
      increased and cyclic monomers were detected. The effects are however less
      pronounced than in group T. One can assume that among abnormal compounds formed
      during heating of linseed oil, cyclic monomers are responsible for the toxic
      effects observed in the present experiment since they have been transmitted to
      the litters either during gestation or lactation.

PMID- 1037077
TI  - [Transference of cyclic monomeric acids into the milk of female rats eating
      thermopolymerised linseed oil].
AB  - Six month old female Wistar rats were fed a commercial diet until littering. Then
      they received a diet containing 10 p. 100 by weight of thermopolymerized linseed
      oil at 275 degrees C for 12 hours under nitrogen atmosphere. No mortality has
      been found among young rats during lactation but body growth is slower. In rats
      sacrificed at the age of 14 days stomach content (milk) and liver were analyzed
      for lipids. In milk and liver fatty acids respectively 2,7 and 3,0 p. 100 cyclic
      monomers (18 C) were detected. Consequently, the present study shows that these
      abnormal compounds formed during hearing of the oil are transmitted to the youngs
      before weaning through mother's milk.

PMID- 1037078
TI  - Transcription of adenovirus DNA by RNA polymerase III of bovine lymphoid tissue.

PMID- 1037079
TI  - [Local anesthesia after percutaneous administration. I].
AB  - Local anesthesia of the intact skin is difficult because of the skin barrier to
      epicutaneous penetration. Using solutions of local anesthetics in organic agents,
      which have the ability of penetrating the skin without causing irreversible
      damage and enhancing the percutaneous absorption of all materials dissolved
      therein, topical anesthesia seems to be attainable. A satisfactory method for
      determining pain threshold in uninjured skin of animals has been set up.
      Measurments of the pricking pain threshold have been made by exposing the skin of
      guinea-pigs to defined mechanical and electrical stimuli. A nociceptive muscle
      reflex (twitch) has been taken as the index of pain sensation. The suppression of
      this twitch has been used as an indicator of anesthetic potency. Two methods have
      been applied with varying parameters: stimulation at a fixed intensity until the
      pain threshold was reached (duration of anesthetic effect) and stimulation with
      increasing stimulus strenght until the cutaneous reflex was elicited (intensity
      or "depth" of anesthesia). The local anesthetic effects of lidocaine, fomocaine
      and procaine bases were studied, after dissolving them in dimethyl sulfoxide
      (DMSO), a wellknown carrier for transmembranal application. The duration of local
      anesthesia measured by electrical stimuli was longer than that obtained with
      mechanical ones. Differences are discussed. All results indicate that fomocaine
      (5%) has a greater local anesthetic potency than procaine (5%) but both are less
      active than lidocaine (5%). No effect could be seen after application of DMSO
      alone.

PMID- 1037080
TI  - [Local anesthesia after percutaneous application. II].
AB  - Cyclohexane and hexadecane have been found to accelerate the penetration of local
      anesthetics (lidocaine, fomocaine, procaine) through the intact skin of guinea
      pigs. Dissolved in cyclohexane, the potency of lidocaine is twice that of
      fomocaine, the latter being more active than procaine. When dissolved in
      hexadecane, the activity of the local anesthetics in markedly reduced. In
      combination with 2-butanone, (30% w/w), a solvent without any apparent effect on
      the permeability of skin, enhanced anesthetic effects are noted. The anesthetic
      bases, dissolved in dimethyl sulfoxide, produce a much deeper and longer local
      anesthetic effect than the solutions of their salts.

PMID- 1037081
TI  - [Malignant lymphoma in a patient with coeliac disease. A clinico-pathological
      study (author's transl)].

PMID- 1037082
TI  - [Electric abdominal epidutaneous findings in the pathology of colonic motility].
AB  - Abdominal epicutaneous electrical activity has been studied in a group of 58
      gastroenterically normal subjects or suffering form colon motor pathology. An
      evident similarity of behaviour was observed in the various groups: 17 out of 18
      subjects with irritable colon and 6 out of 7 with subocclusion of the colon
      presented waves with characteristic amplitude and frequency. This type of
      electrical activity was present in only 1 normal subject out of 20; 11 patients
      with paralysis of the colon did not present waves of note; three patients with
      ulcerative colitis showed behaviour similar to the majority of the normal
      subjects. The technique illustrated would appear adequate for the study of colon
      pathology with motility alterations.

PMID- 1037083
TI  - Temporal patterning of sexual behavior in the female rat.

PMID- 1037084
TI  - Effect of pre- and post-surgical active BCG immunotherapies on murien EAkR
      lymphosarcoma.
AB  - A combined treatment modality incorporating surgery plus BCG immunotherapy was
      administered to (DBA/2 X C57B/6) F1 mice grafted with EAkR lymphosarcoma. 30% of
      mice survived free of disease when BCG was injected intravenously two days after
      operation consisting of tumorectomy plus excision of the regional lymph node
      performed on the 8th day after tumor inoculation. Similar results were obtained
      when BCG was injected subcutaneously 6 days before surgery. Pre-operative
      intravenous and post-operative subcutanous BCG administration failed to cure the
      animals just as BCG or surgery alone.

PMID- 1037085
TI  - Effects of the removal of the regional lymph nodes on the survival of mice
      bearing B 16 melanoma or EAkR lymphosarcoma.
AB  - This work presents data concerning the effect of tumor excision accompanied or
      not by the removal of the regional lymph node (RLN) on the survival time of mice
      bearing the EAkR lymphosarcoma or the B16 melanoma. The operations were performed
      at various times to study this effect in relation to tumor volume. Early
      tumorectomy, on day 6 for the EAkR lymphosarcoma, on day 10 for the B16 melanoma,
      prolonged significantly the survival time. The additional removal of the RLN
      abolished this beneficial effect. In the case of the EAkR lymphosarcoma, a
      beneficial effect on the survival time was in contrast observed after a total
      excision of the tumor accompanied by RLN removal performed on day 8. The two
      surgical procedures were ineffective in increasing the survival time when they
      were applied after the 8th day for the EAkR lymphosarcoma and after the 10th day
      for the B16 melanoma. These results suggest that the preservation of the RLN may
      be favorable for the host at least at an early stage of the tumor growth.

PMID- 1037086
TI  - [Effect of prolonged hyperoxia on rabbit lung lipids and their fatty acid content
      (author's transl)].
AB  - The effect of a 36-hour hyperoxia (60 % oxygen) on rabbit lung lipids has been
      investigated. It has been established that hyperoxia leads to the increase of all
      lipid fractions in lung tissue and alveolar surfactant, phospholipid and
      cholesterol being most significantly affected. It has also been found that
      hyperoxia leads to the decrease of palmitic acid and to the increase of linoleic
      and arachidonic acids almost in all lipid fractions. Marked changes in the
      positional distribution of fatty acids in alveolar surfactant phosphatidylcholine
      have also been observed. The possible mechanisms of the effect of oxygen on lung
      lipid metabolism have been discussed, and the consequences ensuing from it which
      could affect the structural organization of membranes have been evaluated.

PMID- 1037087
TI  - [Contribution to the study of Salmonella in Martinique. Evolution during 1972,
      1973 and 1974].
AB  - In La Martinique a study of 7,861 coprocultures shows that the number of
      Salmonella carriers constantly increases; in 1974, it reaches 3-95 0/0. The main
      serotypes are: S. panama, S. saint-paul, S. typhi murium and S. anatum. Imported
      foodstuffs seem to be responsible for this dissemination.

PMID- 1037088
TI  - [Blastomyces dermatitidis blastomycosis in Africa. First Algerian case].
AB  - A case of fatal generalized Blastomycosis is reported. It was the first case of
      that mycosis observed in Algeria. The parasitic yeast-like cells of the fungus
      were seen in pus and tissue sections and Blastomyces dermatitidis cultured from
      pathological specimens. Yeast-like form was obtained in vitro on Kurung's agar at
      37 degrees C. Male hamsters infected with this strain failed to develop an
      experimental disease. The occurrence and distribution of Blastomycosis in Africa
      are discussed.

PMID- 1037089
TI  - [Prevention of reintroduction of malaria in Reunion in 1972-1973].
AB  - On the island of the Reunion, malaria was eradicated; however the situation
      remains precarious because of the presence there of a very effective vector and
      also because of the frequent trips in neighbouring countries in particular
      Madagascar. The fight against the reintroduction of this formerly prevalent
      disease requires strict control of travellers as well as the detection and rapid
      treatment of imported cases. Ever on a small island with a strong sanitary
      organization; this vigilance can be difficult.

PMID- 1037090
TI  - Epidemiology of cutaneous leishmaniasis in Iran: B. Khorassan Part V: Report on a
      focus of zoonotic cutaneous leishmaniasis in Esferayen.
AB  - During August and September 1975, an epidemiological investigation was carried
      out in another focus of cutaneous leishmaniasis in Khorassan province namely the
      Esferayen district located in the north western part of this province. The
      disease in Esferayen area is of zoonotic type having Rhombomys opimus as
      reservoir and P. papatasi as vector.

PMID- 1037091
TI  - [Human leptospirosis in Martinique].
AB  - Eco-geographic conditions are good for spread of Leptospiroses in Martinique.
      Leptospiroses are widespread in all parts of the Island. Many people have animals
      in inhabitation area. When they are sought, Leptospiroses can be diagnosed.
      During 3 years, we found many cases confirmed by biological diagnosis
      (immunological research of antibodies). Icterohaemorrhagiae is the first
      serogroup encountered and the most frequent. After follow Canicola, Ballum,
      Cynopteri and Javanica. Actually, Leptospiroses are a disease more frequent than
      is generally thought in Martinique. But only the severe cases are hospitalized,
      so diagnosed. Many cases of fever of unknown origin can be Leptospiroses.

PMID- 1037092
TI  - [Imported clinical cases of trichinosis recently observed in Brittany].

PMID- 1037093
TI  - [An epidemic of trichinosis in Paris suburbs. (Preliminary note)].
AB  - A recent trichinosis epidemy involved around hundred patients in southern Paris
      suburbs; most frequent and marked clinical features were: facial and palpebral
      oedema, fever, bowel troubles (mostly constipation; diarrhea was seldom) and
      muscular tenderness. Most of the time eosinophiles cells and muscular enzymes
      were markedly raised. Trichinosis was proved by serological changes, with some
      delay. One muscular biopsy was found positive. Therapy consisted either in
      Thiabendazole (manufacturer's name: Mintezol) sometimes associated with
      prednisolone, or fluoromebendazole. There was no lethality.

PMID- 1037094
TI  - [Wound myiasis caused by Lucilia sericata].
AB  - Report of a case of miyasis in Lucilia sericata infected wounds recently observed
      in Paris in a 67-year-old vagrant. The authors describe the role played by
      Lucilia sericata in therapy before the appearance of sulfanilamides and
      antibiotics.

PMID- 1037095
TI  - [Lipid and protein balance in diabetic Senegalese].
AB  - Lipids and protids in diabetic Senegalese show the following characteristics: 1.
      Lipids. The lipid content of the blood and all its component parts are increased
      in a significant manner in relation to the homologous values of healthy
      Senegalese which are lower than those of Europeans. Therefore diabetic Sengalese
      have the same lipidic values as those of healthy Europeans. 2. Protids. The
      protidic value is higher in diabetic Senegalese than in healthy Senegalese.
      Proteinograms show a particular distribution of the various protidic compounds.
      In effect, if the A/G ratio of healthy Senegalese is 0.8 (1.2 in healthy
      Europeans), the same ratio is equal to 0.4 in diabetic Senegalese.

PMID- 1037096
TI  - Allergy to ingredients of vehicles.
AB  - Common ingredients of vehicles such as perfumes, antibacterial agents,
      emulsifiers and other surface active agents, propylene glycol, lanolin and wool
      alcohols were tested in eczema patients over a three-year period. Perfume allergy
      was detected in 3.6% of the cases, sensitivity to thiomersal in 2%, to sorbic
      acid in 0.8%, to parabens in only 0.3%, and to wool alcohols in 1.2%. Reactions
      to emulsifiers were seen over 1% of those tested.

PMID- 1037097
TI  - Venereal herpes-like molluscum contagiosum: treatment with tretinoin.
AB  - Molluscum contagiosum spread by sexual contact may be mistaken for other venereal
      diseases. The occurrence of a penile lesion resembling herpes progenitalis, and
      successful therapy of genital mollusca with topical tretinoin (vitamin A acid) is
      described.

PMID- 1037098
TI  - New topical agents for dermatophytosis.
AB  - Several new synthetic antifungal agents have recently become available for
      topical use. Reported experiences with haloprogin, miconazole and clotrimazole
      are reviewed. Topical preparations of these agents are nonirritating and
      effective in the treatment of superficial fungus infections. They are effective
      in the management of tinea versicolor and cutaneous candidiasis as well as
      dermatophytosis.

PMID- 1037099
TI  - Herpes simplex and verrucae of the genitalia.

PMID- 1037100
TI  - Diagnosis of anogenital ulcers.

PMID- 1037101
TI  - Nongonococcal urethritis.
AB  - Nongonococcal urethritis may now account for most cases of symptomatic urethritis
      seen at VD clinics in the United States. Well-controlled etiologic studies in
      nongonococcal urethritis have implicated Chlamydia in over 40% of cases but the
      etiology of Chlamydia-negative cases remains uncertain. Tetracycline provides
      effective antimicrobial therapy, but tests for cure are often inadequate, and
      distinguishing relapse and reinfection is difficult. For tetracycline-allergic
      patients, erythromycin should be used. Control measures to decrease transmission
      of nongonococcal urethritis are not well established.

PMID- 1037102
TI  - Nonspecific genital infections.

PMID- 1037103
TI  - Skin changes of the sunset years.

PMID- 1037104
TI  - Social class and morbidity in clinically treated alcoholics.
AB  - The lifetime physical disease profiles of 122 lower and 724 middle class non-skid
      row alcoholics admitted to an inpatient treatment facility were compared to
      further clarify the significance of social class as a determinant of morbidity in
      alcoholics. The overall severity of physical disease and the frequency of all
      recorded lifetime illness diagnoses were greater in the lower than in the middle
      class. The former experienced more trauma, genitourinary disorders, venereal
      disease and malnutrition, as well as small excesses of respiratory and nervous
      system disorders. There were no class differences in the lifetime frequencies of
      liver and biliary tract, gastrointestinal, cardiovascular, endocrine and
      metabolic, integumentary, locomotor and haemopoietic disorders, or in the
      incidences of a number of disease entities including acute brain syndromes and
      chronic brain damage. The drinking patterns of the classes were similar, but the
      average duration of hazardous drinking was longer and the average current
      consumption was greater in the lower class. There were no class differences,
      however, in the average duration of hazardous drinking before the first
      occurrence of certain diseases. The referral sources of the classes were
      significantly different. Possible explanations for the differences between the
      findings of this and earlier studies are discussed.

PMID- 1037105
TI  - [Epidemiological study on the incidence of chronic lymphocytic thyroiditis in
      childhood (author's transl)].
AB  - An epidemiological survey on the incidence of chronic lymphocytic thyroiditis in
      childhood was performed in 11,353 apparently healthy school children in Chiba
      prefecture, Japan. The present study included 9,416 school children (4,401 boys
      and 5,015 girls, ages 6--18 yrs) in Chiba City and 1,937 children (744 boys and
      1,193 girls, ages 16-18 yrs) in Tateyama City. The first group was selected as a
      representative of urban area, and the second group was selected as that of
      seaside area. Children having goiter were selected for testing antihyroblobulin
      and antimicrosomal antibodies in sera. Final diagnosis of chronic lymphocytic
      thyroiditis was based on histological specimens obtained by needle biopsies on
      the antithyroid antibody positive subjects. The overall incidence of chronic
      lymphocytic thyroiditis in these children with 1.7 per 1,000 children. There was
      a considerable sex difference in the prevalence. None of the patients were boys.
      In girls the incidence increased with age: ages 6-12 0.9, ages 13-15 4.6 and ages
      16-18 3.1-4.2 per 1,000, respectively. The incidence in the seaside area, 2.6 per
      1,000 was not significantly higher than that in the urban area, 1.8 per 1,000.
      Histologically, all cases were classified as focal thyroiditis.

PMID- 1037106
TI  - Nutritional requirements of infants and need for supplementing milk diet with
      infant weaning foods.

PMID- 1037107
TI  - Immune deposit nephritis in infectious mononucleosis.
AB  - A 22-year-old white male (L.V.) died of gram-negative septicemia complicating
      infectious mononucleosis (IM) that was associated with jaundice and oliguric
      renal failure. The kidney showed mesangial granular deposits of IgM and C3,
      mesangial electrondense deposits, and interstitial infiltrates of infiltrates of
      mononuclear cells, including atypical lymphocytes. Eluates obtained from kidney,
      spleen and liver contained Paul--Bunnell (PB) antibodies. Presence of PB antigens
      in these tissues was indicated by absorption of PB antibodies from IM sera, with
      the sediments resulting from tissue elutions. The IgM mesangial deposits were
      partially eluted with acid buffer at 56 degrees C and then reconstituted by
      incubation with IM sera or with immunoglobulins eluted from tissues of patient
      L.V. The presence in renal structures of PB antigens, IgM heterophile antibody,
      C3 and electron-dense deposits is consistent with the hypothesis that heterophile
      immune complexes were localized in the kidney and that they contribute in the
      pathogenisis of IM nephritis.

PMID- 1037108
TI  - [Thyroid diseases and autoimmunity].

PMID- 1037109
TI  - [Rift valley fever and rickettsial retinitis including fluorescein angiography
      (author's transl)].
AB  - Three cases of Rift Valley fever retinitis and one case of Tick Bite fever
      retinitis are presented. The clinical features are indistinguishable, manifesting
      as localised areas of retinal ischaemia and soft exudate formation. Fluorescein
      angiography shows that there is primary involvement of the retinal circulation
      without involvement of the choroidal circulation. Vascular occlusion is a feature
      of the retinal pathology. These patients were treated with steroids and
      immunosuppressives as their maculae were threatened and they all regained normal
      to near normal vision except in one case in whom old macula scarring from
      previous episodes of the disease prevented visual improvement.

PMID- 1037111
TI  - [An unusual case of extensive cutaneous aplasia].

PMID- 1037110
TI  - [Daily fluctuations in the P32 content in induced tumors].

PMID- 1037112
TI  - [Combination drug-hormone therapy of the advanced stages of breast carcinoma].

PMID- 1037113
TI  - [Methyl-partricin and vaginitis. Further controlled clinical research].

PMID- 1037114
TI  - [Methyl-partricin tablets in the local treatment of vaginitis with double
      etiology (T. vaginalis and C. albicans)].

PMID- 1037115
TI  - [Effect of lactic-acid milk and kefir on the indicators of acid-base equilibrium
      of arterial blood in healthy young children and patients with acute pneumonia and
      acute bronchitis].

PMID- 1037116
TI  - [Study of mechanical work of the heart in patients with toxic goiter by means of
      electrokymography].
AB  - A study was made of the electrokymogram (EKG) of the left and the right ventricle
      of the heart in 54 patients suffering from toxic goiter chiefly with a marked
      clinical picture of the disease. Electrokymography permitted to detect
      enlargement of the ventricles. Excited pulsation of the ventricles with a rapid
      rise in systole and a sharp fall in diastole pointed to myocardial hyperfunction.
      Rapid and energetic contractions of the heart led to intensification of the
      oscillatory movements of the heart in the chest cavity, and to its rotation. A
      low-wave pulsation with small frequent waves of low amplitude pointed to a
      reduction of the contractile function of the myocardium; this was also indicated
      by the increase of the latent EKG time and the paradoxical movements at the
      beginning of systole. After the effective treatment the EKG of the ventricles
      showed almost no difference from the curves of healthy individuals. Changes in
      the character of the ventricular pulsation in toxic goiter were observed already
      at the early phase of the disease when some of the patients still displayed no
      changes in the ECG, and no X-ray data pointing to the affection of the heart were
      as yet evident. In the presence of phenomena of cardiac insufficiency the EKG
      objectively proved the presence of changes in the myocardium. The EKG data
      corresponded to the severity of the clinical picture of the disease.
      Electrokymography serves as a valuable method for analysis of the function of
      myocardium of the ventricles in toxic goiter.

PMID- 1037117
TI  - [Current problems of psychiatric treatment of the aged].

PMID- 1037118
TI  - [Socio-psychiatric problems of the aging. A practical approach to the community
      care of senile mental disturbances (author's transl)].

PMID- 1037119
TI  - [The problem of the treatment for the aged mental illness from social casework
      point of view--centering around the old person in his own home (author's
      transl)].

PMID- 1037120
TI  - [Symptomatic observation of mental illness of the aged].

PMID- 1037121
TI  - [Nocturnal behavior disorders in elderly patients (author's transl)].

PMID- 1037122
TI  - [An obstacle to relatedness--referring to the aged in the closed therapeutic
      situation (author's transl)].

PMID- 1037123
TI  - [The clinical significance of arteriosclerosis and hypertension in mental
      disorders in the aged (author's transl)].

PMID- 1037124
TI  - [On the combined cases with vascular dementia and senile dementia--analysis of
      the clincal findings of 8 cases (author's transl)].

PMID- 1037125
TI  - [On the therapeutic approach to out-patients with organic dementia based on
      ageing processes of the brain (author's transl)].

PMID- 1037126
TI  - [Clinical studies on senescent changes in intellectual functioning among aged
      women with superior mental activity (author's transl)].

PMID- 1037127
TI  - [A clinical and pathological study on convulsive seizures of the aged (author's
      transl)].

PMID- 1037128
TI  - [A study on the present state of medical care for geriatric and physically ill
      patients in mental hospitals: II. The state of medical and social care for
      geriatric patients in mental hospitals based on investigation on-the-spot. (And a
      supplemental study on the medical and social care for other mental patients)
      (author's transl)].

PMID- 1037129
TI  - [Episodic mental disorders in Wilson's disease (author's transl].

PMID- 1037130
TI  - [An autopsy case of inflammatory diffuse sclerosis (adult case of Schilder's
      disease)--clinicopathological study (author's transl)].

PMID- 1037131
TI  - [An investigation of the developmental neurology in congenital rubella syndrome
      (author's transl)].

PMID- 1037132
TI  - [Ultrastructural changes of the rat cerebellum due to pentetrazol and
      phenobarbital administration--in special references to the changes of synaptic
      vesicles associated with convulsive seizures (author's transl)].

PMID- 1037133
TI  - [2 cases of emaciation in adolescent boys].

PMID- 1037134
TI  - [Hemispheric cerebral dominance].

PMID- 1037135
TI  - [Return of psychiatry to the field of general medicine].

PMID- 1037136
TI  - [The growth hormone].

PMID- 1037137
TI  - [Psychiatric and psychosomatic aspects of tetanico-normocalcemic convulsive
      syndromes].

PMID- 1037138
TI  - [Folic acid and folates: physiopathological and clinical aspects].

PMID- 1037139
TI  - [Cytology, cytopathology and cytopathogenecity of leishmania].

PMID- 1037140
TI  - [Autoallergic hematologic diseases].

PMID- 1037141
TI  - [Biochemical mechanisms of action of catalyzers of ureogenesis and their use in
      human therapy].

PMID- 1037142
TI  - [Tumor antigens in Hodgkin's lymphogranuloma].

PMID- 1037143
TI  - [The NBT test in pediatrics].

PMID- 1037144
TI  - [Physiopathology of renal excretion of phosphates].

PMID- 1037145
TI  - [Long-term peridural obstetrical analgesia by the method of selective supralumbar
      block].

PMID- 1037146
TI  - [Clinical characteristics and treatment of toxic adenoma of the thyroid gland].

PMID- 1037147
TI  - Alterations in pulmonary surfactant following sympathectomy.

PMID- 1037148
TI  - Studies of an inhibitor of the thrombin-fibrinogen reaction localized in rat
      liver microsomes. Interference with the polymerization step.
AB  - A heat-stable, macromolecular inhibitor of the thrombin-fibrinogen reaction
      localized in rat liver microsomes has been shown to interfere with the
      polymerization step in the fibrinogen-fibrin conversion. The inhibitor had no
      effect on thrombin activity as measured with the synthetic, chromogenic substrate
      BZ-Phe-Val-Arg-pNA. The amount of fibrin formed and the release of fibrinopeptide
      A were not affected by the inhibitor. Recording of turbidity at 350 nm and 600 nm
      indicated an inhibition of the lateral aggregation of the end-to-end fibrin
      polymers. The inhibitor was localized in both the luminal and membrane fractions
      of the microsomes. The inhibitor activity was not affected by warfarin treatment
      of the rats.

PMID- 1037149
TI  - Effect of the root extract of Fagara zanthoxyloides on blood coagulation.
AB  - The clot-promoting activity of the aqueous extract of Fagara-zanthoxyloides Lam
      plant is described for the first time. It significantly shortened the PTT (K) of
      normal and factor VIII deficient plasma while it manifested no such action on
      factor IX-deficient plasma. This activity could be demonstrated in the residue of
      the lyophilized aqueous extract after its successive extraction with ether,
      chloroform and methanol. It could not be attributed to the purified fractions:
      Zanthoxylol or its modified form 3, 4-dihydro-2,2-dimethyl-2H-1 benzopyran-6
      butyric acid (DBA), hesperidin, Fagaramide or the ether soluble fraction of the
      aqueous extract.

PMID- 1037150
TI  - The influence of ethanol feeding on the activities of factors II, VII, VIII, IX
      and X in rats.
AB  - The effect of chronic administration of ethanol to rats in a controlled regimen
      upon the activities of the coagulation factors II, VII, VIII, IX and X has been
      studied. No significant differences were found for factor II, IX and X between
      the ethanol-treated rats and the control group given an isocaloric diet with
      carbohydrate replacing ethanol. Factor VII activity was somewhat higher and
      factor VIII activity decreased significantly in the experimental group when
      ethanol treatment was combined with an approximately two-fold increase in dietary
      polyunsaturated fatty acid.

PMID- 1037151
TI  - Bleeding disorder with abnormal wound healing, acid-soluble clots and normal
      factor XIII.
AB  - An unusual bleeding disorder clinically resembling factor XIII deficiency is
      presented. The only detectable coagulation abnormality was rapid clot dissolution
      in 1% monochloroacetic acid. This abnormality was ascribed to the sustained
      increase of  a pepsin-like plasma protease which is activated at low pH.
      Asystematic search for similar phenomena revealed that massive blood transfusion
      may also enhance plasma-clot solubility in acid, possibly by release of a red
      cell protease. We conclude that the acid clot solubility test is not a specific
      indicator of factor XIII deficiency, but this simple assay is recommended for
      further studies of acid plasma protease activity. The diagnostic relevance and
      pathophysiologic importance of increased pepsin-like activity in plasma remain to
      be elucidated.

PMID- 1037152
TI  - Plasma factor XIII and platelet factor XIII in hyperlipaemia.
AB  - Plasma factor XIII activity measured by a quantitative assay was found to be
      significantly higher in hypertriglyceridaemic patients (type IV and combined
      hyperlipoproteinaemia), as compared to normolipaemic controls. No such elevation
      in plasma factor XIII activity was found in patients with type Ha hyperlipaemia.
      Plasma pseudocholinesterase was found to parallel the elevated factor XIII
      activity in hypertriglyceridaemic subjects. In contrast, platelet factor XIII
      activity was not raised in hyperlipaemic subjects, and plasma factor XIII was
      found to be normal in a normolipaemic subjects with thrombocythaemia. It was
      concluded that there is no significant contribution from platelets to plasma
      factor XIII activity, and that the observed increase in plasma factor XIII in
      hypertriglyceridaemia results from enhanced hepatic synthesis of the enzyme.

PMID- 1037153
TI  - Demonstration of reactivity to airborne and food allergens in cutaneous
      vasculitis by variations in fibrinopeptide A and other blood coagulation,
      fibrinolysis and complement parameters.
AB  - In a 32-year-old woman and a 40-year-old man with cutaneous vasculitis,
      etiological allergic responses to foods and airborne allergens were found. During
      provocation tests, observations were made on blood levels of fibrinopeptide
      A(FPA) and coagulation factors, fibrinogen degradation products (FDP) and serum
      complement components. Skin biopsies were taken for microscopic and
      immunofluorescence analysis. In case 1, anaphylactoid allergy to milk and
      reaginic and anaphylactoid hypersensitivity to grass pollens were found. Dermal
      provocations with grass pollens gave arthralgia, hematomas, serum C3 fluctuation,
      factor VII reduction and fibrinolysis. During peroral milk challenge, transient
      increases in FPA and FDP levels were observed before symptoms appeared. In case
      2, anaphylactoid hypersensitivity responses to bacteria, animal danders, foods
      and pollens were found. Two inhalations with sheep-wool extract resulted in a
      typical skin eruption. The first also gave an early reduction of C3 and then FPA
      liberation. Nasal birch-pollen test gave an increase of FPA in the latent period
      and then typical nodules. At least no low molecular weight FDP were detected
      during provocations. In patients with vasculitis reactions to exogenous
      allergens, FPA and FDP estimations after provocations may discriminate harmful
      from innocuous allergens and reveal individual response patterns in coagulation
      and fibrinolysis systems.

PMID- 1037154
TI  - The effect of the fibrinogen concentration and the leukocyte count on
      intravascular fibrin deposition from soluble fibrin monomer complexes.
AB  - Fibrin formation from fibrin monomer (FM) complexes was studied in experimental
      animals utilizing a previously described technique for quantitating fibrin
      deposition. A uniform thrombin infusion was used to produce FM, fibrinolysis
      being inhibited by EACA. In vivo complex formation between FM and 125I-fibrinogen
      was demonstrated chromatographically. A direct correlation was found between
      blood fibrinogen concentration and fibrin deposition in organs. By contrast, an
      inverse correlation between fibrinogen concentration and both enzymatic or non
      enzymatic fibrin formation was found in vitro. The mechanism by which fibrinogen
      potentiates FM precipitation in vivo could not be explained by coprecipitation of
      fibrinogen in the complex which could not be demonstrated. The inhibitory effect
      of HN2 on fibrin deposition despite the associated hyperfibrinogemia induced by
      this drug is believed to underscore the importance of leukocytes in certain types
      of fibrin deposition. A correlation between the leukocyte count and fibrin
      formation from FM was also found. It was concluded that the risk of intravascular
      fibrin deposition is increased by a raised fibrinogen level especially when
      accompanied by leukocytosis.

PMID- 1037155
TI  - Thrombin elaboration in endotoxin-induced intravascular fibrin deposition. A
      leukocyte dependent process distinct from systemic hypercoagulability.
AB  - Intravascular coagulation was induced by two appropriately spaced doses of
      endotoxin and by infusion of thromboplastin. The resulting fibrin deposition was
      measured by a previously described quantitative technique. Evidence of thrombin
      elaboration was obtained indirectly by measurement of fibrin monomer (FM) and by
      the detection and isolation of a thrombin-induced anticlotting activity. Venous
      segments were isolated at intervals and examined for thrombus formation following
      40 minutes of stasis. Endotoxin triggered thrombin elaboration was not detectable
      in the circulation for at least one hour and was not accompanied by any
      thrombosis in isolated venous segments. No thrombin elaboration was found in
      leukopenic rabbits given endotoxin. In the thromboplastin infused animals, the
      quantity of fibrin deposited in the organs was comparable to that found after
      endotoxin. However, thrombin was found in the blood immediately and was
      associated with thrombosis in the isolatet venous segments. Less thrombin-induced
      anticoagulant activity was found after thromboplastin than after endotoxin. The
      findings suggest that endotoxin-induced intravascular coagulation is probably not
      caused by a mechanism of systemic hypercoagulability due to the release of
      thromboplastic material into the blood stream. A focal process of thrombin
      elaboration involving leukocytes is postulated. The study is believed relevant to
      patients with disseminated intravascular coagulation in whom venous
      thromboembolism is rarely found despite evidence of extensive microvascular
      fibrin deposition.

PMID- 1037156
TI  - Inhibitory effect of acetylsalicylic acid on human platelet function in normal
      volunteers and in women using a combined oral contraceptive regime.
AB  - Six parameters related to the release reaction were measured simultaneously in 10
      human volunteers prior to the intake of one single dose of 1 g acetylsalicylic
      acid and 1, 4, 5, 6 and 7 days alter: deltaE5 with diluted collagen, deltaE10
      with Thrombofax and the serotonin-14C release by undiluted and diluted collagen,
      by Thrombofax and by bovine plasma. The duration of the inhibitory effect varied
      according to the test used. It was the most prolonged (through the 7th day) if
      serotonin-14C release by diluted collagen was measured. A systematic
      investigation of the platelet release reaction in women taking a combined oral
      contraceptive was also performed. There were no statistically significant
      differences from a control group. No difference in acetylsalicylic acid
      sensitivity, measured 24 hours after intake of 1 g of aspirin, could be
      demonstrated.

PMID- 1037157
TI  - Effect of aspirin on platelet phospholipids.
AB  - It was observed that the acetylsalicylic acid "in vitro" (final concentration 10(
      4) M) as well as "in vivo" (1 g of aspirin) caused a platelet phospholipids
      variation which basically consisted of: 1. A diminution of the
      phospholipids/proteins rate of 22%. 2. A reduction of sphingomyelin "in vivo" of
      27.66% and "in vitro" of 16.82%. 3. An increase in phosphatidyl choline "in vivo"
      of 12.24% and "in vitro" 10.28%. The possible effects that these changes might
      have on the platelet function are evaluated.

PMID- 1037158
TI  - Impairment of ADP-induced platelet aggregation by hashish components.
AB  - ADP-induced aggregation of washed human platelets is inhibited by the hashish
      components delta1-tetrahydrocannabinol (THC) and cannabidiol (CBD). The
      inhibition is counteracted by added ADP. When the cannabinoids are present at
      concentrations higher than 10(-5)M, the platelets aggregate non-reversibly,
      independently of an added inducer, apparently due to lysis and release of
      endogenous inducers. THC is clearly more potent than CBD in exhibiting the
      biphasic effect. Collagen- and thrombin-induced aggregation of washed platelets
      are hardly affected by the cannabinoids. THC and CBD also curtail ADP-induced
      reversible aggregation in platelet-rich plasma, while serotonin release and
      irreversible aggregation, caused by either ADP, collagen or thrombin, are not
      affected by the cannabinoids in platelet-rich plasma. The data point to
      associated sites for ADP and the cannabinoids on the platelet membrane.

PMID- 1037159
TI  - A new therapy in post-traumatic intravascular coagulation?

PMID- 1037160
TI  - Recurrent thromboembolism with spontaneous platelet aggregation.

PMID- 1037161
TI  - Platelets in the urine: further evidence.

PMID- 1037162
TI  - An inverse relation between platelet factor 4 in the platelet and in the plasma.

PMID- 1037163
TI  - Nature and properties of C3Hf natural antitumor cytotoxins directed against
      murine lymphosarcoma cells.
AB  - The nature and some biological properties of the natural antitumor cytotoxins
      previously found in normal C3Hf serum, have been investigated. By
      immunoelectronmicroscopy study, employing rabbit hybrid antibodies with
      specificity for mouse Ig and ferritin, the C3Hf cytotoxins were shown to belong
      to immunoglobulins. By gel filtration, by inhibition experiments of the cytotoxic
      serum activity with monospecific anti-IgG and anti-IgM sera, and by 2
      mercaptoethanol treatment of the C3Hf serum, the cytotoxic immunoglobulins were
      demonstrated to belong to the IgM class. They were not inactivated by heating
      until 60 degrees C and were able to activate guinea pig, rabbit, and human
      complement. The highest cytotoxic activity of the normal C3Hf serum was found
      when cells and serum were incubated at the low temperature, suggesting a low
      binding affinity of the cytotoxic IgM.

PMID- 1037164
TI  - [Immediate results of surgical treatment of thyrotoxic goiter].
AB  - The author presents an analysis of the results of operations performed for struma
      in 520 patients. There was one lethal issue (0.2%), intraoperative hemorrhage was
      noted in 2.1%, a damage of the n. recurrens -- in 0.9% of patients. The method of
      preoperative preparation and postoperative management in these patients is
      described.

PMID- 1037165
TI  - [Relaparotomy in abdominal injuries in children].
AB  - An analysis of 18 relaparotomies in 12 children with injuries of the abdominal
      organs is presented. Inadequate measures against paresis immediately after
      laparotomy are felt to be the main cause of reoperations for an adhesive-dynamic
      form of the obstruction. While accomplishing relaparotomy, it is recommended not
      to resort to reconstructive operative procedures in cases where a palliative
      operation promptly liquidating complications would suffice.

PMID- 1037166
TI  - [Diurnal rhythm of phosphorus content in transplanted tumors in rats].

PMID- 1037167
TI  - An environmental sanitation plan for the Mediterranean seaboard. Pollution and
      human health.

PMID- 1037168
TI  - [Gallstone ileus and spontaneous healing through fracturing of stones].

PMID- 1037169
TI  - [Comparison of lung-mechanical and physico-chemical Parameters in view of the
      pulmonary surfactant system (author's transl)].
AB  - Evaluation of static pressure-volume-diagram of lungs and of surface-tension-area
      diagram of lung-elutions measured on the Lamgmuir-balance is tested. Well known
      parameters are used to characterize alveolar surfactant activity in guinea pigs
      after perbronchial application of extracorporal surfactant Tacholiquin and
      detergent "Fit" 1% and after application of vagomimetics Acetylcholine 1% and
      Histamine 0.1%. Mean values of physico-chemical parameters show the most
      significant increase of the area of hysteresis (Benzer) during Tacholiquin and
      Acetylcholin application; the minimal surface-tension: gamma min, and the
      compressibility-index: gamma min/delta gamma (Kotter, Ruffer) decreased, the
      difference between maximal and minimal surface-tension: delta gamma and the
      stability-index: 2 delta gamma/(gamma max + gamma min) (Clements) increased.
      Tacholiquin and Acetylcholin both improve pulmonary surface-activity. The
      Tacholiquin-effect is documented in lung mechanics only by elevation of the
      inspiratory volume-rations: V10I/V20I (Clements) and V10I/Vmax (Kittelmann)
      referred to static pressure 10, 20 cm H2O and maximal pressure but not by
      elevation of the expiratory stability index V10E/Vmax (Gruenwald). The area of
      hysteresis is decreased indicating a preponderant inspiratory effect. The
      Acteylcholin-effect is covered by the well-known bronchial obstructive effect.
      Both inspiratory constants are decreased, and the area of hysteresis is
      increased. We did not find any significance of the expiratory stability index.
      Both inspiratory constants and the area of hysteresis are conditional surfactant
      parameters in view of bronchial obstruction.

PMID- 1037170
TI  - [Certain indicators of the results of treatment of psoriasis].

PMID- 1037171
TI  - [Difficulties in the diagnosis of rare malignant kidney neoplasms].

PMID- 1037172
TI  - [Comparative studies of the therapeutic value of metronidazole and carbadox in
      flagellata infections of mice].

PMID- 1037173
TI  - [Lipolytic activity in some Candida strains (author's transl)].
AB  - The authors carried out an examination on the production of lipase in 300 Candida
      strains. The lipolytic activity was present in the majority of strains. In the 60
      of the strains a more precise measurement of lipase production was performed
      qualitatively in a solid medium according to SIERRA (1957) and quantitatively in
      a liquid medium by titration with 0.1 N KOH. Furthermore, the correlation was
      determined between the production of lipase and the Candida growth. It was found
      that the qualitative proof of lipase in a solid medium according to SIERRA (1957)
      is a good informative method for determining lipolytic activity in Candidae. A
      much more sensitive method, however, is the quantitative method in a liquid
      medium; by this method the authors were successful in determining lipolytic
      activity even in some cases where the qualitative test was negative. On the
      whole, Candidae are lipolytically highly active. The mean values of lipase
      production in the Candida albicans cultures is 622 units in 1 ml of liquid
      medium; in other strains it is 798 units in 1 ml. There is a direct relation
      between the density of the culture and the amount of lipase produced.

PMID- 1037174
TI  - The longest symbiotic bacterium as found in a membracid insect.
AB  - An insect tumour cell, carrying germs, contains nuclei and also cellular debris
      as protoplasmic and nuclear degradation bodies. In histological sections the
      nucleus may be seen surrounded by such bodies, cut across, which then appear
      round in form. They have therefore been mistaken for yeast-like germs, called
      "Cicadomyces". But in smears the protoplasmic debris is stained blue and reveals
      bizarre shapes. T. assamensis is an exception and offers the key to properly
      interpret the bodies named Cicadomyces. Its symbiote is a long filamentous
      bacterium and persists in protoplasmic debris, the so-called Cicadomyces. Since
      Cicadomyces themselves cannot be infected by germs as long as themselves, the
      former can only represent cellular degradation bodies.

PMID- 1037175
TI  - [Virus infestation of garden radish (Raphanus sativus L. var. sativus) (author's
      transl)].
AB  - In July 1974 a mosaic disease was stated in seed plants of garden radish near
      Aschersleben which spread more and more within some weeks and eventually infected
      over 40 per cent of the stand. Investigations in comparison with healthy seed
      plants demonstrated the following average losses induced by the disease: number
      of pods 51 per cent, seed weight 67 per cent, number of seeds per plant 53 per
      cent, weight of 1,000 seeds 33 per cent. Nearly unaffected were: number of seeds
      per pod, percentage of seed germination, and percentage of emerged seedlings.
      However, the seedlings were smaller when they derived from diseased mother
      plants. From diseased seed plants cauliflower mosaic virus was isolated. Seed
      transmission of this virus could not be stated with several hundreds of seedlings
      deriving from diseased garden radish. Back transmissions were successful with sap
      and with aphids. Only one strain which was cultivated in greenhouse for a long
      time gave no positive results. Three isolates of cabbage black ring virus from
      different plant species and the four beetle-transmissible viruses, namely turnip
      yellow mosaic, turnip crinkle, turnip rosette, and radish mosaic viruses induced
      no symptoms on garden radish seedlings. However, Erysimum latent virus, also
      belonging to the beetle-transmissible viruses, sometimes caused symptoms in
      garden radish. For the first time the investigations demonstrated in Europe, but
      probably also for the other continents, a spontaneous virus infection of Raphanus
      sativus var. sativus.

PMID- 1037176
TI  - Evaluation of some biological tests as parameters for microbial activities in
      soils. I. Laboratory experiments.
AB  - The experiments were confined to the effects of the addition of different sources
      of carbon (glucose, wheat straw, and sawdust) on the microbial activities in
      soils: loamy sand, loam and saline clay were used. The parameters used for this
      purpose were total bacterial counts, dehydrogenase test, CO2 evolution, and
      oxidation of organic carbon. Salinity of soils had deleterious effects on all the
      parameters used. Addition of organic matter resulted in marked increases in
      bacterial counts, formazan production, and CO2 evolution. Glucose showed the most
      rapid effect and highest levels. Wheat straw yielded the highest results and
      sawdust always showed the least effect.

PMID- 1037177
TI  - Evaluation of some biological tests as parameters for microbial activities in
      soils. II. Field investigations.
AB  - Investigations were designed to study the effect of certain factors on the
      microbial activities in soil. The parameters, used as an index of the microbial
      activities, were total bacterial counts, dehydrogenase activity, oxidation of
      organic carbon, and CO2 evolved/7 days. Bahteem Farm clay soil was examined for
      determining the effects of depth, type of fertilization, and crop rotation on the
      microbial activities. It appears that the microbial activities, as indicated by
      the tested parameters, were more pronounced in the surface 15 cm-layer than in
      the subsurface layer (15-30 cm). Results of all the parameters tested showed
      markedly higher increases with farmyard manure than with nitrogenous fertilizer
      and in the control, without significant differences between the latter two.
      Moreover, the time of sampling had no effect on the results obtained for all
      parameters. Different types of rotations did not exert significant variation in
      total bacterial counts, though more than one crop per year increased the organic
      carbon content of soil and mostly the dehydrogenase activity, whereas the
      evolution of CO2 tended to decrease. At Gabal el-Asfar Farm, the effect of
      irrigation with sewage effluent, for long periods, on the microbial activities of
      sandy soil was investigated. Sewage water stimulated the total bacteria, raised
      the dehydrogenase activity, the organic carbon, and the production of CO2. In
      North El Tahreer and Mariut Sectors, the effect of both the type and age of
      cultivation on the microbial activities in the calcareous soils were examined.
      Cultivation raised the figures of all the tested parameters progressively with
      time of cultivation. It was also noticed that crops exerted more beneficial
      effects on microbial activities than orchards, and the dehydrogenase test was the
      most reliable parameter to reveal this fact.

PMID- 1037178
TI  - [Proof of soil sickness in growing apple plantations (author's transl)].
AB  - 1. Soils from five apple orchards of different age and from different sites were
      tested with respect to the occurrence of soil sickness. 2. Severe or very severe
      soil sickness could be proved in four of the sites. In one site weak soil
      sickness could be obtained. 3. These results confirm earlier observations on the
      occurrence of soil sickness within the regions of growing root systems of older
      trees. 4. The occurrence of soil sickness in growing plantations can be brought
      in good correspondence with the ascertainment that microorganisms associated with
      roots are to be considered as the cause of soil sickness. 5. The significance of
      the occurrence of soil sickness in growing plantations for development and yield
      of trees must be investigated in further experiments.

PMID- 1037179
TI  - Assimilation of phenols by soybean bacteroids.

PMID- 1037180
TI  - Effect of anionic detergents on Azotobacter.

PMID- 1037181
TI  - Biological activities during ripening of composts.
AB  - Three investigations were carried out. The first determined the relationships
      between dehydrogenase acitivty throughout the course of composting wheat straw
      and the changes in both organic carbon and total nitrogen. The second
      investigation tested the validity of the first investigation results. The third
      dealt with the effect of the degree of ripening of a compost, expressed by age
      and C/N ratio, on its dehydrogenase activity, and production of CO2. The results
      revealed continual decreases in the organic carbon, coincident with increases in
      total N and dehydrogenase activity. Noticeable chemical and biological changes
      occurred in the first and third month. Levels of dehydrogenase were highest in
      rice straw and lowest in cotton stalk compost, while the wheat straw compost
      occupied an intermediate position. Aging of the compost resulted in increases in
      the dehydrogenase figures and decreases in the amounts of CO2 produced.

PMID- 1037182
TI  - [The influence of choramphenicol and streptomycinsulphate on the growth of
      Pectobacterium carotovorum var. atrosepticum (van Hall) Dowson (author's
      transl)].
AB  - The influence of the antibiotics chloraphenicol (D-threo-form) and streptomycin
      sulphate against Pectobacterium carotovorum var. atrosepticum (syn. Erwinia
      carotovora) was investigated in vitro and on potato tubers. Chloramphenicol
      showed a greater effect as streptomycinsulphate in the applied concentrations.
      The success of the control of soft rot is determined by the period between the
      inoculation and the treatment of the tubers. 6 several strains of P. carotovorum
      var. atrosepticum showed a different sensibility to chloramphenicol and
      streptomycinsulphate.

PMID- 1037183
TI  - New leaf diseases of barley in Egypt.
AB  - Leaf diseases of barley were observed also in Egypt. From leaves of barley were
      isolated: Helminthosporium teres, H. gramineum, Stemphylium vesicarium,
      Alternaria triticina, Vlocladium chartarum, Acnemonium kiliense, Stemphylium
      spec. accompanied with the Pleospora stage. Inoculations on both attached and
      detached leaves showed that all the tested fungi were pathogenic, except
      Acremonium kiliense and Ulocladium chartarum.

PMID- 1037184
TI  - The formation of heteroagglutinins in rats "chemically" splenectomized by ethyl
      palmitate, in comparison to animals surgically splenectomized.
AB  - In Wistar rats "chemically splenectomized" by an i.v. injection of ethyl
      palmitate the formation of heteroagglutinins against human O-erythrocytes has
      been followed. Ethyl palmitate applied 2 hrs before immunization induced on the
      5th day a significant decrease of the antibody level. This temporary inhibition,
      however, was at a later stage replaced by a significant increase of antibody
      level with the peak of 8--14 days. Animals surgically splenectomized 24 hrs prior
      to immunization displayed a weak antibody response throughout the experiment. An
      injection of the ethyl palmitate on the 6th day after immunization induced a
      pronounced and persistent decrease of the antibody level. Surgical splenectomy
      performed within the same interval had a comparable effect. The experiments
      revealed that the inhibitory effect of ethyl palmitate on antibody production was
      temporary only, and at a later stage could be compensated by an enhanced antibody
      activity.

PMID- 1037185
TI  - [Reactions of hereophilic agglutinins with L-cells and different toxicity of anti
      A HP to fibroblasts and L-cells in vitro].
AB  - The carbohydrate binding glycoprotein Anti-AHP binds to the plasma membrane of
      the (transformed) L-cell both in agglutination reactions and by the
      immunofluorescence technique. On the surface of (normal) mouse embryo fibroblast
      cells Anti-AHP receptors were not detectable. Anti-AHP is suitable as another
      marker for L cells. The random distribution of the binding sites at 4 degrees C
      changes with elevated temperatures (clustering, capping of sites). Anti-AHP
      inhibits the growth of L cells much more than that of fibroblasts. It does not
      act as a mitogen for the investigated cells.

PMID- 1037186
TI  - [Euphoric state and instrumental conditioning].

PMID- 1037187
TI  - [Antitumor activity of carminomycin antibiotic used orally].
AB  - Antitumor activity of karminomycin used perorally was studied with respect to 3
      strains of mouse transplantable tumors, i. e. one ascitic strain of lymphadenosis
      NK/LI and two solid strains of lymphosarcoma L10-1 and sarcoma 180. Karminomycin
      was shown to have a high antitumor activity against the above tumors on its oral
      administration. In the experiments with lymphadenosis NK/LI the efficiency of
      karminomycin was higher when it was used perorally as compared to its intravenous
      administration. It was found that karminomycin had practically the same
      inhibitory effect on growth of lymphosarcoma L10-1 and sarcoma 180 on its peroral
      and intravenous administration in doses equivalent by their toxicity.

PMID- 1037188
TI  - [Preparation of dihydrocarminomycin and a comparison of its antitumor activity
      with the activity of carminomycin].
AB  - A dihydro derivative of karminomycin was prepared using chemical reduction with
      potassium boron hydride. When dihydrokarminomycin was administered intravenously
      to healthy albino mice in a single dose it practically showed the same toxicity
      as karminomycin. However, unlike the latter dihydrokarminomycin induced the death
      of the animals at later periods of time. Studies on mice with transplantable
      tumours showed high antitumor activity of dihydrokarminomycin against
      lymphosarcoma L10-1, sarcoma 180, Garding-Passy melanoma, lymphoid leukosis L
      1210 and lymphocytal leukosis P-388. In treatment of the mice with leukosis L
      1210 and Garding-Passy melanoma dihydrokapminomycin was much inferior by its
      efficiency than karminomycin.

PMID- 1037189
TI  - [Mesenteric ischemia and lumbar ganglionectomy].

PMID- 1037190
TI  - [Extra-adrenal pheochromocytoma associated with bilateral diffuse-nodular
      hyperplasia of the adrenal cortex and micro-macrofollicular goiter].
AB  - At autopsy there was found extra-adrenal pheochromocytoma, bilateral diffuse
      nodulous and adenomatous hyperplasia of the adrenal cortex in a female patient
      who had suffered for a long time from high arterial pressure. In the enlarged
      thyroid gland there was revealed micro-macrofollicular colloid goiter with
      basedowification. The morphological changes and results of an investigation of
      the liquor (drop in the content of potassium) justify the assumption that in this
      case there is a combination of extra-adrenal pheochromocytoma with hormonally
      active rearrangement of the adrenal cortex--primary hyperaldosteronism and
      basedowified goiter.

PMID- 1037191
TI  - Incidence of intestinal parasites in children of different socio-economic
      population of Dacca city.
AB  - Stool samples of 1500 children of different socio-economic status of Dacca city
      was examined for the presence of intestinal parasites. Samples were collected on
      voluntary basis which may be treated as randomised. Out of these 1500 children,
      816 were male and 684 were female. The overall incidence of parasites was 65.80%,
      the male children slightly prepondering over the female children. Children of age
      group 6-10 years showed high incidence of almost all the parasites. Children of
      Basti area showed the highest incidence (about 90%) and most of them harboured
      multiple parasites. About 27.13% of infants under the age of one year (mostly
      from Basti area) harboured parasites. Intestinal parasites were observed that
      both housing and economic status played vital roles in the occurrence of
      intestinal parasitosis but the housing and environmental conditions were found to
      be in a stronger position than economic status.

PMID- 1037192
TI  - Effects of tranquillising, antidepressant and central nervous system stimulant
      drugs on the gamma-aminobutyric acid (GABA) level of rat brain.
AB  - The level of y-aminobutyric acid (GABA) was determined in the brain of rats 1 hr.
      after i.p. injection of chlorpromazine, prochlorperazine, diazepam, trimipramine,
      methamphetamine and nikethamide. Diazepam increased, and, trimipramine and
      amphetamine decreased the brain GABA level over wide dose ranges. Low doses of
      chlorpromazine and prochlorperazine increased but high doses of the drugs reduced
      the GABA level. Low doses of nikethamide reduced whereas high doses increased the
      level of GABA. The effects of the drugs have been discussed in relation to the
      brain GABA level.

PMID- 1037193
TI  - Study of energy expenditure and food intake of some working class people of
      Bangladesh: part -II.

PMID- 1037194
TI  - Infective polyneuropathy (a report of 14 cases).
AB  - Fourteen cases of infective polyneuropathy were admitted in the Institute of
      Postgraduate Medicine and Research, Dacca, during a period of one year. The
      clinical features and laboratory investigations of these patients have been
      recorded. The management was done as usual but particular stress was given to the
      use of a short course of corticosteriod to all patients. The results of treatment
      was satisfactory and uniform for majority of the cases.

PMID- 1037195
TI  - Food intake of the Chittagong Hill tribes of Bangladesh.

PMID- 1037196
TI  - Liver reserve of vitamin A from medico-legel cases in Bangladesh.

PMID- 1037197
TI  - Changes in the process of aging.
AB  - Anthropometric data, caloric intake and blood glucose, cholesterol, urea and
      bilirubin level were compared in a group of elderly persons (mean age, 55.72
      years in males and 52.04 years in females) with a group of young persons (mean
      age, 27.80 years in males and 27.30 years in females) from similar socio-economic
      background. It was observed the elderly persons were slightly heavier than the
      young persons and consumed less calories. In the absence of active disease, the
      blood glucose, cholesterol, urea and bilirubin of the elderly persons were within
      normal limits and comparable to young persons.

PMID- 1037198
TI  - Cirrohosis of liver in Bangladesh, part--II.

PMID- 1037199
TI  - Incidence and causes of blindness amongst the rural population.
AB  - A survey of blindness was conducted in a few union councils of the districts of
      Chittagong, Comilla and Noakhali in a population of 1,14,624 and 1,085 cases of
      blindness (842 adults and 243 children) were detected. The most common cause of
      blindness in the adults was cataract whereas in the children it was corneal
      affection. Trauma constituted 26.7% of blindness in the children and 10.2% in the
      adults. Glaucoma was responsible for 16.3% of blindness in the adults.

PMID- 1037200
TI  - Chronic diarrhoeal diseases in adults (a preliminary report).
AB  - The relationship of chronic diarrhoeal diseases in adults on socio-economic
      condition, parasitic infestation and degree of anaemia have been investigated.
      The disease was more prevalent in poor socio-economic group of people. Most of
      the patients had mixed parasitic infestations. Anaemia was present in all the
      cases. Difference in the degree of anaemia was not significant amongst the
      patients having either Ascaris or hookworm infestation.

PMID- 1037201
TI  - [ On the metabolism of ethyl-DL-trans-2-dimethylamino-1-phenyl-cyclohex-3-ene
      trans-1-carboxylate-hydrochloride (Tilidine-HCl). 2nd Communication: Studies with
      14C-labelled substance on rats and dogs].
AB  - Absorption, distribution, metabolism and excretion of the potent analgesic ethyl
      DL-trans-2-timethylamino-1-phenyl-chclohex-3-ene-trans-1-carboxylate
      hydrochloride (tilidine-HCl, Go 1261 C, active ingredient of Vloron) were
      investigated in rats and dogs, using the radioactively labelled substance.
      Following oral administration, tilidine-HCl is rapidly and completely absorbed
      from the duodenum. During absorption, tilidine undergoes a marked first-pass
      effect. In plasma several metabolites are found, part of them occurring in higher
      concentrations than the unchanged substance. The metabolites are also formed
      rapidly after parenteral administration, unchanged tilidine being found in higher
      concentrations than any of the metabolites at all times measured. Following both
      routes of administration, the Met. I (nortilidine), also possessing a strong
      analgesic activity, reaches similar plasma levels. 14C distribution studies in
      rats showed a relatively high concentration of the radioactivity in the excretory
      organs, liver and kidneys. In brain, muscle tissue and blood much lower 14C
      concentrations are found. The concentrations measured in the foetal organs
      correspond to those in the muscle tissue of the mother animals and are,
      therefore, much lower than in most maternal organs. The radioactivity is
      eliminated from the foetal organs at the same rate as from the maternal organs.
      Tilidine is rapidly and completely eliminated with the excrements, nearly
      exclusively in the form of metabolic products. Rats eliminate 50% of the given
      radioactivity via the kidneys. The relatively high fecal elimination is based on
      the biliary metabolites. Following intraduodenal and intravenous administration
      to rats with an interrupted enterohepatic circulation, about 80% of the dose is
      eliminated with bile. The biliary metabolites are partly reabsorbed. In dogs,
      approx. 80% of the applied radioactivity is eliminated with urine.

PMID- 1037202
TI  - Studies on the determination and induction of cholesterol 7alpha-hydroxylase.
AB  - To determine the activity of cholesterol 7alpha-hydroxylase, different fractions
      from rat liver homogenates are incubated with glucose-6-phosphate, glucose-6
      phosphate dehydrogenase and NADP as well as with cholesterol-4-14C. The 7alpha
      hydroxycholesterol-4-14C formed is separated from the extract of the incubation
      preparation by means of thin-layer chromatography and its radioactivity is
      calculated as a percentage (conversion figure) of the total radioactivity on the
      plate. The highest conversion is found in the 18 000 X g supernatant. It is of
      the order of 1--4%. This activity decreases to about one-half when the homogenate
      or the cell fraction is stored, while cooling, for two days. It can be shown that
      repeated pretreatment of rats with phenobarbital increases the activity of
      hepatic cholesterol 7alpha-hydroxylase by more than three times over the control
      values. 1-(2'-Hydroxyphenyl-acetyl)-4-methyl-1,2,3,6-tetrahydropyridine (Bay a
      4798) a choleretically active drug also increases the activity of this enzyme in
      the rat more than twofold. This effect is confirmed by reduced biliary excretion
      of radioactive cholesterol and increased biliary excretion of radioactive bile
      acids following i.v. administration of DL-mevalolactone-2-14C and continuous
      intraduodenal infusion of Bay a 4798.

PMID- 1037203
TI  - [On the mode of action of difenoxin (R 15 403). Part 2: Studies on the perfused
      isolated colonic loop of the rat (author's transl)].
AB  - The effect of 1-(3-cyano-3,3-diphenylpropyl)-4-phenyl-isonipecotinic acid
      hydrochloride (difenoxin, R 15 403), a new antidiarrhoic agent, was studied in
      vivo in rats with an isolated colonic loop. Difenoxin had no effect on transport
      or absorption of fluid during perfusion experiments. When given i.p. it inhibited
      the motility of the coecum but not that of the colon. Difenoxin has apparently no
      effect on normal rat colon, although an effect may have been masked by the wide
      variation of parameters measured under identical conditions.

PMID- 1037204
TI  - [Pharmacology of 2'-[2-hydroxy-3-(propylamino)-propoxy]-3-phenylpropiophenone
      (Propafenone, SA 79)-hydrochloride].
AB  - The pharmacologic actions of 2'-[2-hydroxy-3-(propylamino)-propoxy]-3
      phenylpropiophenone (propafenone, SA 79) hydrochloride were investigated in
      animal experiments. The drug showed antiarrhythmic action in anesthetized dogs,
      cats and rabbits after i.v. (1 mg/kg) and oral (2-10 mg/kg) application. The
      model arrhythmias were induced by epinephrine infusion plus chloroform inhalation
      or by infusion of digoxin, calciumchloride or aconitine or by occlusion of the
      left coronary artery. Propafenon prolonged the refractory period in isolated
      atria of guinea pigs and elevated the electrical fluttering level of the
      ventricle in anesthetized guinea pigs or conscious rabbits. It showed local
      anesthetic action on the cornea of the guinea pigs. In doses of 3-10 mg/kg i.v.
      it lowered blood pressure, inhibited contraction force of the heart ventricle and
      dilated coronary arteries. Heart rate was unchanged by anti-arrhythmic doses.
      With higher doses (more than 7 mg/kg i.v.) ECG was altered. The autonomic nervous
      system was unaffected but bronchial adrenergic beta-receptors appeared to be
      inhibited. The results show, that propafenon has a specific antiarrhythmic action
      on the heart. The doses to be used have no influences on other circulatory
      parameters. Propafenon acts after oral application too.

PMID- 1037205
TI  - Gas chromatographic determination of dimethophrine in biological specimens of
      rabbit.
AB  - A method to measure the alpha-sympathomimetic amine, 1-(3,5-dimethoxy-4
      hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine, DMP), was developed and
      applied for the determination of the drug in biological specimens. The gas
      chromatographic degradation of the drug was investigated, and in order to avoid
      this process, DMP is converted to the trifluoroacetyl derivative and assayed by
      gas liquid chromatography on an OV 1' column. The minimum detectable amount is 25
      pg per injection. Linearity (using hexachlorobenzene as internal standard for
      quantitation) was found up to mug amounts of the substance, without any
      interference with endogenous substrates. Values from plasma, red blood cells and
      urine in rabbits treated with a single dose of DMP (10 mg/kg) are also reported.

PMID- 1037206
TI  - Drug absorption from the irradiated rat small intestine in situ.
AB  - The absorption of acidic drugs phenobarbitone and sulphafurazole, basic drugs
      mecamylamine and quinidine, and a neutral drug isoniazid was studied in situ.
      Rats were irradiated 750 rad whole-body with 60Co and the absorption experiment
      was done three and six days thereafter using the cannulated small intestine of
      urethane-anaesthetized rats. Drug disappearance from the intestinal lumen and
      drug levels in the whole blood and intestinal wall were measured. In control rats
      phenobarbitone showed the most rapid absorption and mecamylamine the slowest.
      Irradiation retarded the disappearance of all drugs from the intestinal lumen on
      the third postirradiation day. Fluid absorption was also diminished. On the sixth
      postirradiation day the absorption of phenobarbitone, sulphafurazole and
      mecamylamine had returned to the control level, but the absorption of quinidine
      and isoniazid was still retarded. After i.v. administration of drugs they were
      not significantly excreted into the intestinal contents and irradiation did not
      modify excretion. The distribution of drugs between the intestinal fluid and the
      intestinal wall was complete in the first 10 min of experiment. Mecamylamine and
      quinidine were lowered in the whole blood by irradiation. Blood levels of drugs
      did not correlate well to the rate of disappearance of drugs from the intestinal
      lumen. The reversible changes in absorption induced by irradiation are probably
      secondary effects of irradiation on intestinal morphology, permeability and
      transport capacity, composition, and possibly blood flow.

PMID- 1037207
TI  - [Suitability test of various food mixtures for breeding and rearing of beagle
      dogs. 2nd Communication: Methods and results of feeding experiments of the
      Mannheim team (author's transl)].
AB  - A comparison of 3 commercially available dog foods (Ssniff C, Altromin H,
      Altromin HW) with 2 newly formulated dog food mixtures was carried out with
      regard to breeding, rearing and maintenance of Beagle dogs. No significant
      differences were found between the individual feeding groups with regard to the
      fertility and breeding ability of the bitches. All the foods supplied the
      requirements for energy, nutrients and feed additives in the rearing and
      maintenance of the dogs. The parameters used for the assessment, such as body
      weight, daily gain, daily food consumption and feed efficiency, were satisfactory
      for all food groups and were partially reproduceable. If the consumption of food,
      energy and nutrients per kg body weight are calculated and are related to the
      rearing results obtained then inconsistencies occur which can only be explained
      by differences in digestibility of the individual food components, and these
      underline the need for digestibility tests in dogs. The 2 newly formulated foods
      compared favourably with the other food stuffs and fulfilled the requirements for
      better standardised food mixtures. Further experiments will investigate the
      effects on the morphological, haematological and clinico-chemical
      characteristics. A comparison of different age groups confirmed the data in the
      literature which indicates that younger animals have a higher requirement for
      energy and nutrients per kg body weight than older animals. Results that have not
      yet been explained are the findings that the consumption of food, and thus of
      energy and nutrients, per kg body weight in younger male animals is lower than
      that of the female animals of the same age to a highly significant degree.

PMID- 1037208
TI  - Posthaemorrhagic iron deficiency. Clinical course, 59Fe whole-body iron losses,
      and oral iron supplementation.
AB  - Clinical and laboratory data characterizing post-haemorrhagic anaemia with still
      normal iron stores and posthaemorrhagic iron deficiency in the manifest, latent
      or prelatent stage are presented. Initially, increased 59Fe whole-body iron
      losses (greater than 0.1-3.6%/day) returned to normal range (less than 0.1%/day)
      after haemostasis. Subsequently, slow increase of haemoglobin and repletion of
      iron stores occurred under normal diets. Manifest, latent, and prelatent iron
      deficiencies were corrected much more rapidly by total doses of 12.0, 10.5 and
      8.0 g iron (Fe2+ sulfate), respectively, when 2 X 50 mg/day were given in quick
      release capsules apart from meals.

PMID- 1037209
TI  - The effect of colestipol on digitoxin plasma levels.
AB  - The effect of colestipol (colestipol hydrochloride; U-26 597 A), a copolymer of
      tetraethylenepentamine and epichlorhydrine, on plasma digitoxin levels has been
      investigated. Recently, it has been stated that colestipol decreases the
      enterohepatic circulation and the plasma half-life of digitoxin. Colestipol was
      administered to 11 patients having a digitoxin plasma level which is generally
      accepted to be above the therapeutic range (greater than 40 ng/ml). The
      elimination rate of digitoxin measured by serial radioimmunoassay in these
      colestipol treated patients was compared with the elimination rate of digitoxin
      in 11 patients not treated with colestipol. The results of this study did not
      demonstrate a significant difference in the mean (+/- S.D.) digitoxin plasma half
      life between the colestipol treated (6.3 +/- 1.3 days) and the non-colestipol
      treated patients (6.8 +/- 1.0 days).

PMID- 1037210
TI  - The influence of cholic acid and dehydrocholic acid on the biliary excretion of
      unconjugated and conjugated sulfobromophthalein in rats.
AB  - Urethane anesthetized Wistar rats with biliary fistulas were infused during 100
      min with sulfobromophthalein (BSP), the glutathione conjugate of
      sulfobromophthalein (BSP-GSH), cholic acid (CA) and dehydrocholic acid (DCA). The
      dyes (594 nmol/100 g/min) and the bile acids (1200 nmol/100 g/min) were infused
      separately, and in combination as well. When BSP was infused, CA and DCA
      increased the maximal excretion of total BSP (conjugated plus unconjugated) from
      1400 to 4100 and 3300 nmol/100 g/10 min. The bile flow observed with BSP plus CA
      was not significantly different from that with BSP plus DCA. The biliary
      excretion of total BSP was higher throughout with CA than with DCA because CA
      increased the biliary concentration of PSP while DCA did not. The bile flow
      attained with CA alone was significantly lower than that with BSP plus CA. The
      current data provide arguments for abandoning the view that choleresis per se is
      the crucial determinant for BSP excretion. When BSP-GSH was infused instead of
      BSP, the excretion rate of the dye was not altered by the additional infusion of
      CA whereas it was significantly reduced by DCA. The maximal biliary concentration
      of BSP-GSH fell from 25.9 nmol/mul to 15.3 and 9.4 nmol/mul with CA and DCA,
      respectively. Both CA and DCA impaired the hepatic uptake of BSP and BSP-GSH.
      During the infusion with CA, BSP plus CA and BSP-GSH plus CA the biliary
      excretion rates of bile acids did not differ significantly from each other. This
      favours the view that the transfer for CA from the liver to bile is different
      from that for BSP and BSP-GSH. A fraction of bile fluid "independent of
      choleretics" (viz. of bile salts, BSP and BSP-GSH) is estimated and discussed in
      view of the different types of infusion.

PMID- 1037211
TI  - The synthesis of ethyl apovincaminate.
AB  - Starting from (+) vincamine (I), simple derivatives of vincaminic acid (II),
      apovincaminic acid (V) and apovincaminol (VII) were synthetized. Out of these the
      synthesis of ethyl apovincaminate (Cavinton), as a representative, is described
      in detail. The water elimination and esterification of II can be carried out in
      one step.

PMID- 1037212
TI  - General and cerebral haemodynamic activity of ethyl apovincaminate.
AB  - Systemic and cerebral haemodynamic effects of ethyl apovincaminate (RGH-4405,
      Cavinton), a new compound, have been investigated in anaesthetized dogs. The
      compound was administered i.v. and produced an increase in cerebral blood flow
      accompanied by a decrease in cerebral vascular resistance which persisted for 15
      min. The effective dose was 0.2-0.5 mg/kg. Mean arterial blood pressure, total
      peripheral resistance and cardiac work were decreased, heart rate and cardiac
      output were increased. Cerebral metabolic rate of oxygen was enhanced. It is
      assumed that the compound has a direct effect on cerebral metabolism. RGH-4405
      has a weak antiarrhythmic and coronary dilating activity. Its effect on smooth
      muscle is more marked than that of papaverine. RGH-4405 appears to be a potent
      cerebral vasodilator enhancing cerebral metabolism.

PMID- 1037213
TI  - Effect of oral pretreatment with ethyl apovincaminate on the cardiac output and
      nutritive blood flow of various organs in rats.
AB  - Effect of ethyl apovincaminate (RGH-4405, Cavinton), administered repeatedly p.o.
      in doses of 0.5-1.5-4.5 mg/100 g body weight for 5 days, on cardiac output and
      organ fractions of cardiac output were studied in rats anaesthetized with sodium
      pentobarbital by Evans-blue dilution and isotope fractionation technique of
      Sapirstein. Cardiac output, cerebral, coronary, renal, intestinal and dermal
      blood flow was increased by 18-42% after 4.5 mg/100 g Cavinton, while blood
      pressure was unaltered. Total peripheral resistance, cerebral, coronary, dermal
      resistance and that of the carcass decreased significantly. Organ fractions of
      the cardiac output were not significantly altered after treatment.

PMID- 1037214
TI  - Effect of ethyl apovincaminate on cerebral, cardiac and renal flow rate in dogs
      in the course of administration.
AB  - Cerebral, myocardial and renal capillary flow rate was significantly increased by
      10 to 20 mug/kg/min doses of ethyl apovincaminate (RGH-4405, Cavinton) injected
      in slow infusion to dogs. These effects were long-lasting. Since perfusion
      pressure and heart rate were not affected by the compound, it was concluded that
      increased flow rate was attributable to decrease of peripheral vascular
      resistance. Results indicate that Cavinton has a vasodilatory effect.

PMID- 1037215
TI  - Protective activity of ethyl apovincaminate on ischaemic anoxia of the brain.
AB  - Effects of ethyl apovincaminate (RGH-4405, Cavinton), a new cerebral metabolic
      and vasodilatory agent, on cerebral regulatory functions under ischaemic anoxia
      were studied on immobilized cats by EEG. Cortical resistance time increased and
      recovery time decreased for a long period after i.v. administration of the
      compound. Results point to the possibility of further enhancement of cerebral
      regulatory processes by specific drug effects. It is assumed that tolerance or
      adaptation to hypoxia might be increased by RGH-4405 if spontaneous regulatory
      processes are impaired.

PMID- 1037216
TI  - Effect of ethyl apovincaminate on cerebral circulation of dogs under normal
      conditions and in arterial hypoxia.
AB  - Effects of 1, 2 and 4 mg/kg i.v. doses of ethyl apovincaminate (RGH-4405,
      Cavinton) on cerebral blood flow, determined in the internal carotid and
      vertebral artery, were studied in anaesthetized dogs under 21, 16 and 11% O2
      inhalation. Total cerebral blood flow was increased by 4 mg/kg Cavinton under
      normal O2 and between 100 to 200 mmHg perfusion pressures, while 2 mg/kg doses
      were effective under hypoxia. Similar phenomena were observed in the carotid and
      vertebral flow, separately. Arterial hypoxia seems to potentiate the effect of
      Cavinton on cerebral blood flow.

PMID- 1037217
TI  - Effects of ethyl apovincaminate on the central nervous system.
AB  - Side effects of ethyl apovincaminate (RGH-4405, Cavinton), a cerebral
      vasodilatory agent, on the central nervous system were studied on mice and rats.
      Anticonvulsive effect in electroshock was observed as major CNS effect, locomotor
      activity was reduced due to muscle relaxant effect. The compound had no sedative
      effect on rodents. Its analgesic effect was negligible. Cavinton had neither
      antidepressive, nor anticholinergic activity.

PMID- 1037218
TI  - Pharmacokinetic data on tritium labelled ethyl apovincaminate.
AB  - Absorption, tissue distribution and excretion of tritium labelled ethyl
      apovincaminate (RGH-4405, Cavinton) were studied. Both oral and i.p.
      administration resulted in a relatively rapid elimination of tritium activity,
      suggesting that neither the original drug nor its metabolites remained in the
      organism of rat. 50% of radioactivity was recovered in urine and 30% in faeces
      during 48 h. At this time only liver and kidneys contained measurable quantities
      of radioactivity among the organs tested. Biliary route of elimination seemed to
      be important, since 20% and 4% of radioactivity appeared in bile during 9 h
      following i.p. and p.o. administration, respectively. Enterohepatic circulation
      was of no consequence. Radioactivity was hardly adsorbed to or absorbed by blood
      cells and was almost completely bound by plasma protein(s).

PMID- 1037219
TI  - Metabolism of ethyl apovincaminate in the rat.
AB  - Ethyl apovincaminate (RGH-4405, Cavinton) is well metabolized in rat, and only a
      small fraction of the original compound is excreted in urine. The main urinary
      metabolite is apovincaminic acid, hydrolytical product of Cavinton produced
      partly by plasma esterases. In plasma only the original compound and free acid
      are detectable. Several other metabolites have been isolated from bile and
      characterized by mass spectrometry. Cavinton is hydroxylated at the indole moiety
      and forms conjugates (possibly glucuronide and sulfate). The glycine derivative
      of apovincaminic acid containing two hydroxygroups has been detected in
      significant amounts, analysed by mass spectrometry. Among minor metabolites
      vincaminic acid ethyl ester has been found. More than 80% of total urinary and
      50% of total biliary metabolites have been identified by radiochromatography,
      mass and IR spectroscopy.

PMID- 1037220
TI  - Summary of safety tests of ethyl apovincaminate.
AB  - Subchronic toxicity test (4-week p.o. on rats with 25 and 100 mg/kg; 3-month i.p.
      with 5 and 25 mg/kg; 3-month i.v. with 2 and 5 mg/kg daily doses on dogs) and
      chronic toxicity tests (6-month p.o. on rats with 25, 50 and 100 mg/kg and on
      dogs with 5 and 25 mg/kg daily doses) were performed with ethyl apovincaminate
      (RGH-4405, Cavinton), a cerebral vasodilatory compound, to study adverse effects
      in adult age. Reproduction tests (male and female fertility test on rats p.o.
      with 10 and 50 mg/kg; teratogenicity test in midpregnancy on rats p.o. with 12.5,
      25, 50 mg/kg, 15, 50, 150 mg/kg, and 15, 45, 135 mg/kg daily doses, i.v. with
      3.13, 6.25 and 12.5 mg/kg daily doses; on rabbits p.o. with 6, 12 and 18 mg/kg
      daily doses; peri- and postnatal studies in late pregnancy on rats p.o. with 15,
      45 and 135 mg/kg i.v. with 4.13, 6.25, and 12.5 mg/kg daily doses) were carried
      out to study harmful effects in various early phases of life. Local tolerance was
      studied after i.m. and i.v. application. It was concluded that the planned 3 X 5
      or 3 X 10 mg daily oral dose, 1 X 10 mg i.v. dose of Cavinton were safe for human
      application in adult age. Although the compound proved not to be teratogenic, it
      is not recommended for administration to pregnant women because of liability of
      increased sensitivity in pregnancy. Therapy of women in fertile age should be
      interrupted in case of pregnancy.

PMID- 1037221
TI  - Effect of ethyl apovincaminate on the cerebral circulation. Studies in patients
      with obliterative cerebral arterial disease.
AB  - The effect of ethyl apovincaminate (RGH-4405, Cavinton) on the cerebral and
      systemic circulations has been studied in detail in ten cases of cerebrovascular
      disease. 10 mg doses of Cavinton were given as infusion within 4-6 min;
      circulatory tests were carried out prior to administration of the drug and 3-6
      min after. The principal results showed the following: On Cavinton cerebral
      vascular resistance was strongly reduced, while cerebral fraction of cardiac
      output significantly increased. On acute effect of the drug arterial mean
      pressure slightly decreased but cerebral blood flow nevertheless increased in
      general. Total vascular resistance also decreased but this decrease was less
      marked than that registered in cerebral vascular resistance.

PMID- 1037222
TI  - Rheoencephalographic and psychological studies with ethyl apovincaminate in
      cerebral vascular insufficiency.
AB  - The effect of ethyl apovincaminate (RGH-4405, Cavinton) on the rheoencephalogram
      and memory functions was studied in 50 patients with ischaemic disturbances of
      cerebral circulation. The drug was administered in a single i.v. dose of 10 mg
      and orally three times daily 5 mg for a month. Improvement of cerebral
      circulation was observed after i.v. and oral medication. Blood flow was most
      markedly increased in the gray matter. The effect on arterial pressure was
      negligible. Improvement of memorizing capacity evaluated by psychological tests
      was recorded after one month of Cavinton treatment, associated with alleviation
      or complete disappearance of symptoms. No side-effects attributable to the drug
      were observed. It is pointed out that Cavinton is indicated in the treatment of
      ischaemic disorders of the cerebral circulation, particularly in chronic
      insufficiency.

PMID- 1037223
TI  - Study on the vasodilator effects of ethyl apovincaminate in neurosurgical
      patients.
AB  - Studies have been performed in a series of 44 neurosurgical cases. The patients
      were subjected to detailed neurological examination and EEG after admission and
      before being discharged. The effect of ethyl apovincaminate (RGH-4405, Cavinton)
      on cortical electric activity was investigated after the administration of 10 mg
      i.v. Cavinton. In cases on long-term courses of three times daily 5 mg Cavinton
      in tablets, control EEG was performed one and two months, respectively, after the
      start of medication. The state of vessels of the eye-ground was also checked. In
      cerebral angiography attention was concentrated on width of the vascular lumen
      and visualization of Cavinton effect on vessels which on account of narrowing or
      spasm had not filled up with contrast medium prior to Cavinton. During
      angiography the patients were given i.v. 10 mg. Cavinton diluted to 10 ml with
      physiological saline. In the cases where investigations failed to reveal any
      change requiring neurosurgical intervention and insufficient cerebral circulation
      had to be held responsible for the patient's condition, three times 10 mg
      Cavinton i.v. was administered daily as long as the patient was at our
      Department. After having been discharged these patients took three times daily 5
      mg Cavinton in tablets. Duration of the course of oral Cavinton depended on the
      degree of improvement in the patient's condition. Cavinton was used with success
      in cases where cerebral circulation was damaged for functional or organic
      reasons. Allergic hypersensitivity did not occur in any of the cases, either on
      single doses or long-term use of parenteral or oral Cavinton.

PMID- 1037224
TI  - The effect of ethyl apovincaminate on the circulation of the eyeground.
AB  - Ethyl apovincaminate (RGH-4405, Cavinton), contrary to the active vasodilators
      used up to the present, increases blood pressure of the eyeground. Dynamics of
      the eyeground circulation has been investigated with fluorescein angiography
      performed at certain points of time. Blood supply of the macula lutea was
      increased in the first place by Cavinton.

PMID- 1037225
TI  - Use of ethyl apovincaminate in ophthalmological therapy.
AB  - Ethyl apovincaminate (RGH-4405, Cavinton) has been administered to 100
      predominantly arteriosclerotic patients to increase circulation in the eyeground.
      Visual acuities improved in 88 cases, by 73% in average; in twelve cases there
      was no change, but deterioration did not occur. Improvement was still more
      significant (267%) in occlusions and retinopathies associated with
      atherosclerosis of the central retinal artery. The dose of Cavinton was 20 mg in
      drop infusion or three times daily 10 mg i.v. Side-effects, if any, disappeared
      spontaneously upon reduction of the dose. The improvement paralleled the
      increases of the blood pressures in the central retinal arteries. This increase
      of pressure head is suggested to dilate passively the vessels.

PMID- 1037226
TI  - Preliminary report on the use of ethyl apovincaminate in affections of the
      eyeground.
AB  - 26 ophthalmological patients have been given daily doses of three times 1 tablet
      (15 mg) ethyl apovincaminate (RGH-4405, Cavinton) for periods of from two weeks
      to three months. Improvement of visual acuity lasted as long as the course of
      treatment, in agreement with the results of other authors. On Cavinton effect
      blood flow increased in the retinal precapillary and capillary system, supply of
      hypoxic areas improved. Improvement noted in choroid sclerosis bears witness to
      the effect of Cavinton on choroid capillaries.

PMID- 1037227
TI  - Vasodilating effect of ethyl apovincaminate on conjunctival vessels and
      simultaneous observation of parameters indicating adverse effect.
AB  - The vasodilator effect of ethyl apovincaminate (RGH-4405, Cavinton) on
      conjunctival vessels and its possible adverse effects have been studied in 17
      patients of varying age (16-78 years) and diagnosis, as well as in healthy
      individuals. Intravenous 10 mg doses of the drug increased the arteriolar lumen
      in each case, the most markedly at 30 sec after administration of the drug, but
      at 90 sec effect was still significant. Before starting Cavinton, on the next day
      following injection and on other mornings after administration, haemoglobin, the
      leukocyte count, SGOT, SGPT, thymol turbidity, and blood sugar were determined.
      In the eight cases of juvenile hypertension urinary serum proteins were also
      registered after quantitative testing. The parameters investigated did not reveal
      any sign pointing to toxicity.

PMID- 1037228
TI  - Ethyl apovincaminate in the treatment of sensorineural impairment of hearing.
AB  - Ethyl apovincaminate (EGH-4405, Cavinton) treatment has been used in various
      sensorineural impairments of hearing as well as in ear diseases associated with
      vertigo. As shown by experinces, presbyacusis, vascular impairment of hearing and
      in certain cases toxic hypacusia are improved by Cavinton. Besides audiometric
      improvement of pure tone, significant improvement was noted in the speech
      audiogram in all three groups of disease. Certain affections of the ear
      accompanied by vertigo responded to Cavinton. In Meniere's disease it has proved
      to be superior to the vasodilators used up to now.

PMID- 1037229
TI  - Comparative study of the effect of ethyl apovincaminate and xantinol nicotinate
      in cerebrovascular diseases. Immediate drug effects on the concentrations of
      carbohydrate metabolites and electrolytes in blood and CSF.
AB  - Randomly selected 34 cerebrovascular patients were treated with ethyl
      apovincaminate (RGH-4405, Cavinton) and 109 with xanitinol nicotinate. The
      effects of drugs given in slow i.v. infusions on the concentration of
      carbohydrate metabolites and electrolytes in serum and CSF were observed.
      Cavinton improved the paresis in 60.6% of patients while xantinol nicotinate did
      so only in 47.1%. On the basis of the biochemical changes it can be concluded
      that Cavinton enhances both the glycolytic and the oxidative glucose breakdown in
      CNS.

PMID- 1037230
TI  - Ethyl apovincaminate therapy in neurovascular diseases.
AB  - Of a series of 100 patients 46 were given combined (i.m. and oral) treatment with
      ethyl apovincaminate (RGH-4405, Cavinton) in daily doses of 10-30 mg; 54 were put
      on oral Cavinton (30-45 mg daily). Significant and relatively quick improvement
      was obtained in reversible vascular diseases, such as hypertensive
      encephalopathy, intermittent vascular cerebral insufficiency, in the early stage
      or light cases of cerebral endarteriitis and cerebral arteriosclerosis. On
      Cavinton effect hypoxic character of the EEG improved, and so did performance in
      psychodiagnostic tests, alertness and memory in the first place, furthermore
      changes of the eyeground. The doses administered did not damage parenchymal
      organs, they did not cumulate and when used in combination incompatibility could
      not be observed.

PMID- 1037231
TI  - Quantitative structure-activity relationships. IV. Non-linear dependence of
      biological activity on hydrophobic character: a new model.
AB  - A new model is derived for the dependence of biological activity on hydrophobic
      character from a simple hypothetical system. Unlike the parabolic Hansch model
      this model can explain the peculiar effect that for homologous series of
      compounds the logarithms of biological activities of the lower homologs are
      linearly dependent on hydrophobic character, while for the higher homologs the
      relationship between biological activities and hydrophobic character changes to a
      parabola. Although these relationships are known and several appropriate models
      were proposed, the bilinear model presented in this paper is the first which can
      be described by a simple and generally valid equation: log 1/C = a log P--b log
      (beta - P + 1) + c While the parameters a, b and c can be calculated by linear
      multiple regression analysis, the non-linear term beta must be derived by a
      stepwise iteration process or ty Taylor series iteration. Examples are given for
      comparison of the bilinear model and the parabolic Hansch model.

PMID- 1037232
TI  - Metabolic degradation of propanidid by various tissues. Short communication.
AB  - The very short anaesthetic action of 3-methoxy-4-(N,N-diethylcarbamoyl-methoxy)
      phenylacetic acid propylester (propanidid, Epantol) is due to its rapid
      hydrolysis in vivo. In this study, the rates of degradation of this drug under
      the influence of various isolated tissues have been established. The drug was
      hydrolysed much more rapidly by liver homogenate than by whole blood or serum. It
      is concluded that inactivation of propanidid in vivo occurs mainly by the liver,
      whereas blood esterases play an insignificant part in hydrolyzing the ester.
      Moreover, it was demonstrated that cardiac tissue is able to hydrolyze the drug
      as well. It is postulated that the inactivation of propanidid by heart muscle
      might partly compensate for the severe cardiodepressive action of the anaesthetic
      agent. A gaschromatographic determination of propanidid has been developed.

PMID- 1037233
TI  - [N-Methylphenethylamine, an indirect sympathicomimetic agent in vegetables
      (author's transl)].
AB  - N-Methylphenethylamine, a secondary amine present in vegetable foodstuffs, in
      concentrations up to 6.6 ppm, is an indirectly acting sympathomimetic amine; on
      i.v. injection the circulatory effects correspond to 1/80 to 1/100 of those of
      epinephrine. Following enternal application pressoric and positive chronotropic
      effects are observed during appr. 30 min; the no-effect level amounts to about 7
      mg/kg.

PMID- 1037234
TI  - [The course of blood pressure and organ changes in rats with DOCA-hypertension].
AB  - In 45 control rats and 47 nephrectomized, DOCA-implanted, hypertensive rats
      (hypertensive phase), blood pressure, weight gain, development of pathologic
      anatomical histological changes as well as changes in the myocardial enzyme
      pattern were studied over 24 weeks and after absorption of the DOCA tablet the
      return of the animals to normal conditions (follow-up phase) for another 14
      weeks. During the hypertensive phase, blood pressure rose to 233 mm Hg on the
      average within 10 weeks and remained constant up to the 22nd week. In the follow
      up phase, it dropped sharply, at first, and then slowly returned to normal.
      Weight gain was the same in DOCA and control rats. Relative weights of heart,
      kidneys and liver were elevated in the hypertensive phase but fell again in the
      follow-up phase. The pathologic-histological changes formed in the hypertensive
      phase, such as myocardial hypertrophy, glomerular hyalinization, tubular dilation
      and perivascular fibrosis, were remitted in part. Unchanged, however, the
      enhanced heart score persisted evidencing a proliferative vasoconstriction.
      Except for a pronounced, reversible increase in MAO activity, the cardial enzyme
      pattern remained unchanged during the experiment.

PMID- 1037235
TI  - [Study on novel morphine antagonists in the animal experiment (author's transl)].
AB  - The morphine-antagonistic properties of 5 novel compounds, (--)N-(3-Furylmethyl)
      nordesomorphine-hydrochloride-monohydrate (Wa 494-Cl), (--)N-(3-Furylmethyl)-3
      hydroxy-morphinan-methansulfonate (Mr 1257 MS), (--)2-(3-Furylmethyl)-2'-hydroxy
      5,9alpha-dimethyl-6,7-benzomorphan-methansulfonate  (Mr 1452 MS), (+/-)-2-(3
      Furylmethyl)-2'-hydroxy-5,9alpha-diethyl-6,7-benzomorphan-hydrochloride (Mr 1302
      MS), (--)-N-(3-Furylmethyl)-noroxymorphon-methanesulfonate (Mr 1767 MS), have
      been examined with different methods on mice and cats. Their properties have been
      compared with those of naloxone, cyclazocine and nalorphine. The new test
      compounds showed a profile of action like naloxone.

PMID- 1037236
TI  - [Studies on the metabolism and distribution of 14C-sodium nitroprusside in rats
      (author's transl)].
AB  - Studies on the in vivo degradation of 14C-labelled nitroprusside (NP) were
      conducted in rats and indicated that the primary product was cyanide and not
      thiocyanate. With the administration of higher doses of sodium nitroprusside
      (NNP; Nipruss) cyanide, thipcyanate, Fe++ and Fe+++ were evident in the blood
      plasma, whereas [Fe(CN)6]4- and [Fe(CN)6]3- were not detected. The biological
      half-life for the disappearance of nitroprusside was about 2 min with a dose of
      0.4 mg NNP/kg and was 28 min with a dose of 6.25 mg NNP/kg. Nitroprusside and its
      degradation products, cyanide and thiocyanate, were eliminated mainly in the
      urine. Significant accumulation of nitroprusside did not occur either in blood
      vessel walls, in smooth muscles, or in parenchymal organs.

PMID- 1037237
TI  - [Studies on the interactions of chlordiazepoxide, nitrazepam, and diazepam with
      phenprocoumon (author's transl)].
AB  - The interaction of benzodiazepine derivatives with phenprocoumon (Marcumar) was
      investigated after a single dose of the combination of phenprocoumon/diazepoxide
      (Librium), phenprocoumon/diazepam (Valium) and phenprocoumon/nitrazepam (Mogadan)
      had been applied to rats. By means of the high pressure liquid chromatography
      (HPLC) the change of concentration of these pharmaceutical agents per unit time
      in serum was determined and related to the corresponding change of prothrombin
      time. Hence it can be concluded that the benzodiazepine derivatives influence the
      distribution of phenprocoumon in the organism.

PMID- 1037238
TI  - [Distribution and excretion of a glycosaminopolysulfate in the rabbit after
      parenteral application (author's transl)].
AB  - The pharmacokinetics of unlabelled and tritium-labelled glycosaminoglycan
      polysulfate (GAGPS) was examined by gel chromatography, electrophoresis and
      radiometry. The compound was given i.m. and, for comparison, i.v. In both cases
      (dose: 7.5 mg/kg) blood levels after 1 h reached maxima of approx. 6 mug/ml and
      remained between 2.0 and 1.5 mug/ml for between 24 and 48 h. The question of
      threshold-limited excretion is discussed. The concentration curves of the synovia
      were almost identical to those of the blood. The cartilage of the joint had a
      comparable level after 48 h (1.7 mug/g), whilst the level was lower in rib
      cartilage (1.1 mug/g). Urinary excretion within 24 h amounted to 45% of almost
      unchanged GAGPS. A further 10% were excreted within the following 24 h. The
      residue was distributed chiefly in the kidneys, liver, skin, spleen, gut, and
      bone marrow. In the course of the elimination time the excreted substnace showed
      a lower molecular weight as was found by gel chromatography.

PMID- 1037239
TI  - Effects of chloroquine on the adrenocortical function. II. Histological,
      histochemical and biochemical changes in the suprarenal gland of rats on long
      term administration of chloroquine.
AB  - White female Wistar rats were used in order to study the influence of long-term
      oral application of 7-chloro-4-(4-diethylamino-1-methylbutylamino) quinoline
      (chloroquine) in doses of 30, 40 and 80 mg of base/kg upon the suprarenal gland.
      Histological, histochemical and biochemical findings give evidence of
      adrenocortical activation induced by chloroquine at all dose levels tested. The
      differences between the signs of adrenocortical activation as observed after the
      various doses were only those of quantity and time onset. The results indicate
      that the stimulation of the suprarenal cortex produced by repeated administration
      of chloroquine is not solely a manifestation of toxic action of chloroquine.

PMID- 1037240
TI  - The mechanism of the vasodilator effects of histamine and 4-methylhistamine in
      the hindquarters of the cat.
AB  - Intraarterial administration of histamine and 4-methylhistamine induced a fall in
      perfusion pressure of perfused hindquarters of the chloralose-anesthetized cat.
      Mepyramine which is a histamine H1-receptor blocker competitively inhibited the
      depressor effect of histamine without altering that of 4-methylhistamine.
      Continuous intravenous infusion of metiamide, which is a histamine H2-receptor
      blocker, to the mepyramine treated cats caused a further inhibition in response
      to histamine as well as 4-methylhistamine. These results indicate that both
      histamine H1- and H2-receptors are present in the vasculature of the cat
      hindquarters and both of them are responsible for the vasodilator effect of
      histamine.

PMID- 1037241
TI  - Serum kinetics and urinary metabolism of dimethophrine in rat.
AB  - The serum kinetics and urinary metabolism of an a-sympathomimetic amine 1-(3,5
      dimethoxy-4-hydroxyphenyl)-2-monomethyl-amino-ethanol (dimethophrine) were
      studied. For serum kinetics, seven groups of 6 rats were sacrificed at 0.083, 1,
      2, 2, 4, 6 and 12 H, respectively, after tail administration of dimethophrine-7
      3H. Only 1 group of 6 rats was placed into metabolism cages to collect urine at
      12-h intervals during the 72 h after dimethophrine-7-3H administration as above.
      The metabolic identification was made by thin-layer chromatography (TLC) and the
      radiochromatograms were obtained by the "scraping" method. This work shows
      dimethophrine to be unchanged in the urine of rat.

PMID- 1037242
TI  - Effect of 4-methylumbelliferone on the oxidative metabolism of liver mitochondria
      in jaundiced rats and its relationship of choleretic action.
AB  - The effect of 4-methylumbelliferone (4-MU) on the oxidative metabolism of liver
      mitochondria and its relationship to choleretic action were investigated on 40
      bile duct-ligated rats and 40 rats after biliary decompression. The oxidative
      metabolism of liver mitochondria fell rapidly to 50% of controls within 7 days
      after bile duct-ligation, whereas that in rats with 4-MU fell only slightly. Such
      effect of 4-MU on the liver mitochondrial metabolism was most prominent when it
      was administered to rats after biliary decompression. In rats with 4-MU the
      depressed oxidative metabolism of cholestatic liver mitochondria recovered
      rapidly toward normal with accelerated amelioration of serum total bilirubin as
      compared to that in rats without 4-MU after biliary decompression by loosening of
      the ligation of the common bile duct. Thus, 4-MU appeared to exert some
      stimulation or amelioration of the impaired liver mitochondrial metabolism due to
      jaundice, which may have a close relationship to its choleretic action or
      effective bile excretory action.

PMID- 1037243
TI  - [Specific incorporation of labelled tissue homogenates into the homologous organs
      of the rat (author's transl)].
AB  - The time course of the incorporation of radioactivity into the liver, kidney,
      heart, spleen, lung, adrenal glands, and testes following subcutaneous
      application of L-histidine-2,5-T-labelled homogenates of liver, kidney and heart
      has been measured in 105 male Sprague-Dawley rats aged 3 months (weight: x = 350
      g). The homogenates had been prepared from organs of rats of the same age, sex
      and weight, each labelled with 400 muCi L-histidine-2,5-T. The maximal
      incorporation of activity from the homogenates into the organs investigated has
      been found 24 h after injection. In the kidney, however, an additional peak
      appeared already 5 h post applicationen. The comparison of the activities of the
      liver, kidney and heart, taking into account the differences in organ metabolism,
      revealed a significantly higher incorporation into the homologous than in the non
      homologous organs. This specific incorporation appeared 2 h after the injection
      and could be found until about 24 h. The type of labelling, the method of sample
      preparation and the time of absorption allowed to conclude that the specific
      affinity to the homologous organs might have been due to a relatively small
      amount of short peptides. The functional significance especially for the
      regeneration of impaired organs has been discussed taking into account earlier
      results.

PMID- 1037244
TI  - Effect of 1,5-dicaffeoylquinic acid on ethanol-induced hypertriglyceridemia.
      Short communication.
AB  - Male Wistar rats were administered acutely and chronically ethyl alcohol. The
      effect of 1,5-dicaffeoylquinic acid (cynarine) on ethanol induced
      hypertriglyceridemia and on hepatic concentration of triglyceride was
      investigated. In rats treated acutely with ethanol the serum and hepatic
      triglycerides showed significant rise by 216 and 111%, resp. The prolonged
      administration of ethanol caused insignificant increase of the serum triglyceride
      concentration by 40%, while its hepatic content was significantly increased by
      100%. In rats receiving ethanol and cynarine simultaneously, distinct reduction
      of the serum and hepatic triglyceride concentration was observed.

PMID- 1037245
TI  - Pharmacological aspects of pyrazoline derivatives from 2-hydroxy-butenolides.
AB  - A series of pyrazoline derivatives was synthetised and evaluated for
      toxicological and pharmacological effects; analgesic, hypnotic, anti
      inflammatory, antipyretic and cardiovascular properties were screened. Tested
      compounds were found to have a low toxicity; one of them showed a good analgesic
      activity without side effects.

PMID- 1037246
TI  - Inhibition of gluconeogenesis by sodium nitroprusside in the perfused guinea pig
      liver.
AB  - Sodium nitroprusside was found to be a very strong inhibitor of the glucose
      formation from lactate in the perfused guinea pig liver. Hepatic cell respiration
      and oxidative phosphorylation appeared to be simultaneously suppressed by this
      compound. The pattern of some hepatic metabolite concentrations was similarly
      affected by nitroprusside as described for biguanides and pyridinium chloride
      derivatives. Cyanide had to be added to the perfusion medium in a tenfold higher
      concentration to achieve a comparable inhibition of gluconeogenesis from lactate.

PMID- 1037247
TI  - Absorption and disposition of econazole nitrate after application to the skins
      and vaginas of rabbits.
AB  - 1. The absorption and tissue distribution of radioactivity has been studied in
      rabbits after application of a cream containing 10 mg of the 3H-labelled 1-(2,4
      dichloro-beta-[(p-chlorobenzyl)oxy]phenethyl) imidazole nitrate (econazole
      nitrate, Pevaryl) to the normal or abraded skins of rabbits. 2. Approximately one
      third of the dose was absorbed through the occluded normal skins of rabbits
      during 8 days, mainly during 7 to 24 h. In the same time interval, slightly more
      of the dose was absorbed through the occluded abraded skins of rabbits at
      slightly greater rates. Co-formulation of triamcinolone acetonide in the cream
      reduced and delayed the peak rates of absorption through normal and abraded skin,
      but the extent of absorption during 8 days was similar in the presence or absence
      of triamcinolone acetonide. 3. After application to normal skin or abraded skin,
      the peak of mean concentrations in the plasma of 220 ng/ml (range 132-276 ng/ml)
      or 307 ng/ml (range 270-321 ng/ml), respectively, occurred at 24 h. Tissue
      distribution of radioactivity was similar after application to normal or abraded
      skin, and concentrations were highest in the liver, kidneys and gastrointestinal
      tract (which are the organs of biotransformation and excretion) and also in the
      adrenals and to a lesser extent in the uterus, ovaries and untreated skin. 4.
      After application of a cream containing 5 mg of 3H-econazole nitrate to the
      vaginas of rabbits, approximately one-third of the dose was absorbed during 8-24
      h, and rates of excretion were higher through the more permeable vaginal
      membrane. 5. After vaginal doses of 5 mg, a peak concentration of 209 ng/ml
      occurred at 6 h in the plasma. Tissue concentrations of radioactivity after
      vaginal doses were highest in liver, kidneys, gastrointestinal tract, adrenals
      and ovaries, and the tissue distribution was similar to that observed after
      cutaneous doses.

PMID- 1037248
TI  - Self-administration of caffeine by the rat.
AB  - Rats with permanently implanted right jugular vein cannulae were either pre
      treated with increasing doses of caffeine for up to 98 h, or underwent no pre
      treatment. Both groups were then presented with a lever, the pressing of which
      caused a self-injection of a caffeine solution. For both groups, some of the rats
      self-administered caffeine for up to 4 days and then their activity stopped; the
      other rats did not self-administered caffeine.

PMID- 1037249
TI  - [A contribution to the subject of the parameters PQ, QRS and QT being functions
      of heart rate in the ECG of the beagle dog (author's transl)].
AB  - We examined the degree of dependency of the ECG parameters PO, QRS and QT on the
      heart rate. In 252 beagles of standardised breeding and accommodation (strain:
      Chbi : BEAGLE), a total of 1456 ECG recordings was made from the three Einthoven
      extremity leads, and the heart rate and PQ-, QRS-, and QT-times were measured.
      The animals used were dogs from eleven subacute toxicity studies. 683 of the
      registrations were obtained from control animals and 773 from drug-treated
      animals whose ECG curves had remained unchanged and in which no histopathological
      changes were found in the heart at the end of the toxicity studies. The data
      obtained were biometrically evaluated by regression and correlation analyses. The
      range of the heart rate was 34-238 actions/min, median value 108. The range of
      the PQ interval was 0.07-0.18 sec, the QRS interval 0.03-0.09 sec and the QT
      interval 0.14-0.26 sec. The median values were 0.11, 0.05 and 0.19 sec,
      respectively. Positive skew distributions were found. The data were transformed
      to obtain values with normal distribution. The various correlation coefficients
      were then heart rate/PQ time: -0.408 (p less than 0.001), heart rate/QRS time: 
      0.057 (p less than 0.05), heart rate/QT time: - 0.611 (p less than 0.001). This
      means that the PQ and QT intervals clearly decrease as the heart rate increases,
      whereas the QRS interval is only minimally affected. Correlation ellipses were
      also calculated and presented graphically. These show areas within which 50, 75,
      90 and 95% of our values are to be expected.

PMID- 1037250
TI  - [Suitability of various food mixtures for breeding and rearing of beagle dogs. 3.
      Methods and results for the Ingelheim team].
AB  - Two different modes of nutrition during breeding and rearing of dogs are
      investigated to determine which of them has the better effect. The use of a
      complete feed for breeding and maintenance (Altromin H) was compared with the use
      of a special breeding feed (Zahn Z), respectively, together with a special
      maintenance feed (Zahn H). A palatability test was made, a 2-year test for the
      effect on breeding, observation of weight gain and food consumption in the
      rearing phase on all the dogs of the strain Chbi:BEAGLE. The palatability test
      showed no preference for either diet. Initially, on changing diets, the dogs ate
      more of whichever new food was given. From 22 parameters which characterize the
      breeding effect the only statistically significant difference determined was an
      11% higher consumption in the Altromin H group. Although in the rearing phase the
      food consumption in the Altromin H group was higher, male dogs in the younger age
      group made more weight gain on the special food (Zahn Z) and older bitches fed
      Altromin H were heavier for a time.

PMID- 1037251
TI  - [A quantitative gaschromatographic method for the determination of p
      chlorophenoxyisobutyric acid (clofibrinic acid) in human plasma (author's
      transl)].
AB  - The report describes a sensitive and selective GLC-method for the plasma level
      estimation of p-chlorophenoxyisobutyric acid (CPIB), the biologically active
      metabolite of clofibrate. After addition of an internal standard substance the
      acid is extracted and converted to its methylester by diazomethane. Following
      oral administration of equimolar doses of clofibrinic acid and clofibrate (445
      and 500 mg, respectively) to 4 normal volunteers plasma concentrations could be
      measured for 72 h. A comparison of different pharmacokinetic parameters indicated
      that the two compounds gave almost identical absorption profiles in respect of
      CPIB. CPIB disappeared from plasma with a mean half-life of 17.6 h.

PMID- 1037252
TI  - [Studies on the biotransformation of 5-vinyl-5-(1-methylbutyl)- and 5-vinyl-5-(1
      ethyl-propyl)-barbituric acid (author's transl)].
AB  - After taking 5-vinyl-5-(1-methylbutyl)-barbituric acid (vinylbital, Speda)
      another not yet known metabolite (Sp 1) was isolated from urine and was
      identified as 5-vinyl-5-(1-methyl-3-carboxy-propyl)-bartiburic acid. Compound Sp
      2a is 1-methylhydantoin. Presumably this compound is an artifact from creatinine.
      We have not yet been able to identify a third mercury(I)-nitrate-positive
      substance Sp 2b. The supposition that this compound were a metabolite of 5-vinyl
      5-(1-ethyl-propyl)-barbituric acid could not be upheld. The three mercury(I)
      nitrate-positive substances appearing in the urine after taking 5-vinyl-5-(1
      ethyl-propyl)-barbituric acid, behaved in chromatographic analysis completely
      differently from the unknown compound Sp 2b. The substances were isolated. Two of
      them are the metabolites 5-vinyl-5-(1-ethyl-2-carboxy-ethyl)-barbituric acid and
      5-(1-ethyl-propyl)-barbituric acid. We are not sure whether the third compound
      identified as 5-hydroxy-5-(1-ethyl-propyl)-barbituric acid, is formed in vivo, as
      the substance could have developed by oxidation or by the influence of peroxide
      contained in ether, as well. A product hydroxylized in the side chain, like in
      vinylbital, was not found in the metabolite urine of 5-vinyl-5-(1-ethyl-propyl)
      barbituric acid.

PMID- 1037253
TI  - [Pharmacokinetics and metabolism of trazodone in man (author's transl)].
AB  - After intravenous, intramuscular and oral administration of 25 mg 14C-labelled 2
      (3-[4-(m-chlorophenyl)-1-piperazinyl]-propyl)-s-triazolo[4,3-a]pyridin-3-(2H)-one
      hydrochloride (trazodone), plasma levels, elimination and metabolite pattern in
      plasma and urine were investigated. The plasma levels after all routes of
      administration are almost identical. The absorption of the compound is fast and
      complete. The elimination of radioactivity occurs in a biphasic manner with a
      half-life of 1 h for the earlier and 13 h for the second phase, no matter what
      application route had been chosen. The comparison of the plasma levels of fasted
      and non-fasted subjects shows a shift of the plasma maximum from 1.5 to 2.5 h
      following administration and a decrease in the maximum level of 30%. The
      radioactivity is excreted predominantly by renal processes (70-75% within 72 h).
      The main product in plasma is unchanged trazodone, whereas in urine it is found
      only in minute amounts. The radioactivity in urine is represented by conjugates
      that had formed after hydroxylation on the chlorophenyl residue (20%), by a
      dihydrodiol-metabolite of trazodone (15%) and by a carboxylic acid originating
      from oxidative cleavage of the parent compound (35%).

PMID- 1037254
TI  - A comparative study of the hemodynamic effects of single intravenous doses of 3
      hydrazino-6-[N,N-bis-(2-hydroxyethyl)-amino]-pyridazine-dihydrochloride and
      hydralazine.
AB  - The new pyridazine derivative 3-hydrazino-6-[N,N-bis(2-hydroxyethyl)-amino]
      pyridazine-dihydrochloride (DL 150 IT) was administered to five hypertensive
      patients at the dose of 50 mug/kg by i.v. bolus injection. A parallel group of
      five patiens received 250 mug/kg of hydralazine. Hemodynamic measurements were
      obtained before treatment, and then after 30--60 and 80-120 min. Cardiac output
      was evaluated by radiocardiography and myocardial perfusion by clearance of 86Rb.
      The antihypertensive effect of DL 150 IT was most pronounced 2 h after the
      injection, whereas by this time the increased heart rate and cardiac output
      tended to revert to the baseline values. On the contrary, the magnitude of these
      effects did not change during the observation period after hydralazine treatment.
      Both drugs increased myocardial perfusion. The new compound appears at least five
      times more potent than hydralazine and, possibly, has a longer duration of
      action.

PMID- 1037255
TI  - [Intestinal absorption from therapeutic iron doses (author's transl)].
AB  - On a total of 105 persons with normal iron stores, iron depletion, and iron
      deficiency the intestinal absorption from therapeutic iron doses (100 mg Fe and
      50 mg Fe as ferrous glycocoll sulphate) of a special galenic form was measured.
      The measurements were performed by means of a whole-body counter and preparations
      labelled with radio-iron (59Fe). Mean values of absorption rates from 100 mg Fe
      in healthy males were 5.0% and in healthy females 5.6% whereas in latent iron
      deficiency and in iron deficiency anemia mean values of 10% and 13% were
      obtained, respectively. The maximum absorption rate of 20 to 25% is reached
      already in the late stage of latent iron deficiency. Advancing severeness of iron
      deficiency is not followed by an increase of iron absorption. Investigations on
      21 persons showed no significant difference between absorption rates of the
      galenic preparations used when administered orally before or after breakfast,
      respectively.

PMID- 1037256
TI  - Effect of an ergot derivative on human lymphocyte chromosomes in vivo.
AB  - Chromosome examination was made from 12 healthy adult male volunteers by using
      human lymphocyte cultures twice before, and 8 and 12 weeks after continuous
      intake of 3 X 1.5 mg Hydergine, an ergot derivative, per day orally. The mean
      frequency of cells with aberrations and the number of aberrations per 100 cells
      after 12 weeks' medication corresponded well with those of control cultures.
      However, for unknown reasons, significantly different values were found after 8
      weeks of medication at a level of 5%, i.e., the values of capillary blood culture
      C8W were lower than those of CI, CII and C12W.

PMID- 1037257
TI  - [Polygraphic sleep recordings in patients with endogenous depression before and
      after treatment with amitriptyline-N-oxide (author's transl)].
AB  - 15 endogenous-depressive patients were treated with 3 X 20 mg amitriptyline-N
      oxide for 20 days. Polygraphic sleep recordings were taken during the first seven
      and last six nights. In a single-blind study the patients were given placebo for
      the first four days, amitriptyline-N-oxide was applied during the following 13
      days and on the last three days placebo was given again. The statistical
      evaluation showed the following results: a) Latency times up to the first deep
      sleep and to the first REM-phase decreased under the effect of the substance. b)
      Relative sleep duration (without wakefulness) increased. c) Actual sleep duration
      (without wakefulness and stage A) was similar. d) The frequency of awakenings
      during the night diminished under amitriptyline-N-oxide and increased somewhat
      when placebo was given again. The original values were not reached. The frequency
      of awakenings from REM-phases increased during the first three nights of
      medication and decreased in the last three nights the substance was administered.
      When placebo was given again, the original values were exceeded. e) Duration of
      wakefulness after waking up during the night decreased under amitriptyline-N
      oxide and increased when the medication was discontinued. Here again the original
      values were not reached. After waking up during the night most waking time was
      spent in stage C. A placebo effect can be excluded. The effects of amitriptyline
      N-oxide are compared to those of hypnotics, other antidepressants, antipsychotics
      and tranquilizers in the discussion.

PMID- 1037258
TI  - A sub-chronic study of the subjective quality of sleep and psychological measures
      of performance on the morning following night time medication with temazepam.
AB  - A sub-chronic study of 7-chloro-2,3-dihydro-3-hydroxy-1-methyl-5-phenyl-1H-1,4
      benzodiazepin-2-one (temazepam, Euhypnos) at three dose levels was carried out in
      30 healthy volunteers. A matching placebo was given before and after the 4 nights
      of active compound. The subjective response was measured by means of a sleep
      evaluation questionnaire, and the objective measurements used were the critical
      flicker fusion threshold and choice reaction time. A clear dose-response
      relationship was seen in the subjective and objective measurements with the three
      doses used. A rebound phenomenon was seen only at the high dose levels in two
      subjective measures, viz. getting to sleep and behaviour following waking.

PMID- 1037259
TI  - Pharmacology of dihydroxy-dibutylether, a specific choleretic drug.
AB  - The choleretic and the general pharmacological properties of dihydroxy-dibutyl
      ether (Discinil) were investigated in several animal species. Discinil (DHBE)
      increased the bile flow in conscious rats and dogs, after both oral and i.v.
      administration. A choleretic effect was also observed after i.v. injection into
      anaesthetized rats and guinea pigs. A dose-response relationship was always
      obtained, the threshold dose being 25--100 mg/kg. No evidence of tachyphylaxis
      was observed in rats after repeated treatments. The bile hyperflow was generally
      accompanied by an increased excretion of the total dry residue in guinea pigs and
      dogs. The choleretic effect in rats was still present after pretreatment with
      either DL-ethionine (causing parenchymal liver damage) or atropine (blocking the
      cholinergic control of bile production). At low doses (25--100 mg/kg i.v.)
      eliciting a definite choleretic response, DHBE did not show spasmogenic and
      spasmolytic effects in vivo on the smooth muscles of the gallbladder of guinea
      pigs and dogs, neither on the stomach and intestine of mice and dogs; while it
      constricted the pylorus sphincter of rats. At larger doses (200--400 mg/kg i.v.)
      the compound showed a mild relaxing activity on Oddi's sphincter of guinea pigs
      and a weak spasmogenic activity either on gall bladder or on small intestine. In
      vitro, it caused an unspecific antagonism against the spasm induced by
      acetylcholine, barium chloride, histamine, 5-hydroxytryptamine and
      norepinephrine. In anaesthetized rats, rabbits and dogs, DHBE caused a moderate
      and short-lasting hypotension, and tachycardia. The threshold doses for these
      effects were 2--4 times superior to those being choleretic. In conscious dogs,
      the compound was slightly hypertensive. DHBE did not provoke important
      respiratory and ECG changes, neither showed diuretic nor antiphlogistic effects.

PMID- 1037260
TI  - [On the determination of triamterene, hydroxythiamterene and hydroxytriamterene
      sulphate ester in biologica material by direct evaluation of thin-layer
      chromatograms (author's transl)].
AB  - The quantitative measurement of 2,4,7-triamino-6-phenylpteridine (triamterene),
      as well as its metabolites hydroxytriamterene and hydroxytriamterene sulphate
      ester, is described. Estimation of urine, plasma and faecal samples was achieved
      by a direct fluorometric method following separation on kieselgel plates. The
      procedure allows the simultaneous assay of the three substances on the plate
      without the need for previous chromatographic separation or derivatisation.

PMID- 1037261
TI  - Synthesis and pharmacological study of diphenylalkylamines with cycloaliphatic
      residues. New coronary vasodilators.
AB  - The paper describes the synthesis and the pharmacological evaluation of some
      derivatives of prenylamine, all with a cycloaliphatic ring within or instead of
      the isopropylamine moiety. Their general formulas are: (C6H5)2CH-CH2-CH2-NH-CH
      CH2-R CH2 (I) (C6H5)2CH-CH2-CH2-NH-R' (II) where R contains and R' is a
      cycloaliphatic ring. Several compounds and particularly those of formula (I), and
      of formula (II), where the alicyclic ring had a bulky substituent in para were
      more active than prenylamine as coronary vasodilators on isolated guinea-pig
      heart (Langendorff). The most interesting derivative was M.G. 8926 [N-(3,3
      diphenylpropyl)-alpha-methyl-beta-cyclohexylethylamine], which was more active
      than prenylamine on Langendorff's heart and in enhancing the pressor response to
      catecholamines and inhibiting the isoprenaline induced hypotension. Moreover, it
      had almost the same effects as prenylamine as spasmolytic, local and general
      anesthetic, on heart rate and arterial pressure and against coronary spasm from
      pitressin.

PMID- 1037262
TI  - [Anaerobic serum ultrafiltration--a new method for determination of protein
      binding rates of drugs under physiological conditions (author's transl)].
AB  - Only the free and not the protein-bound fraction of a drug shows pharmacologic
      activity. Therefore the rates of drug-binding to serum proteins are of great
      importance for clinical and pharmacological purposes. A basis prerequisite for
      accurate measurements are experimental designs giving the possibility of keeping
      the most important factors influencing the protein-binding rate within
      physiological ranges. In vivo these factors are, among others, the concentration
      of albumin, the absorption of different exogenous and endogenous substances to
      albumin, the type and the amount of ions present, the total ionic strength, the
      pH-value and hence the pCO2 as well as the temperature. An experimental set-up
      was described giving the possibility of keeping all these factors absolutely
      constant under in vivo conditions by means of a newly developed and simply to
      handle ultrafiltration device. From withdrawing the blood sample from the vein to
      the complete separation of the protein-bound fraction the blood sample can be
      processed under strictly anaerobic conditions (to prevent loss of CO2!). Compared
      to common methods generally used for the determination of protein-binding rates,
      such as equilibrium dialysis, column chromatography and ultracentrifugation, this
      new procedure saves a considerable amount of time. Within 1 h up to 8 samples can
      be processed in a single device. Besides short filtration times there is no need
      for any additional sample preparation such as buffering or adding antibacterial
      substances, etc.

PMID- 1037263
TI  - [A new fluorometric method for the determination of drugs in biological material
      (author's transl)].
AB  - A description is given of a new method for fluorometric determination of drugs in
      biological material. The assay is based on photochemical transformation of non
      fluorescent compounds in fluorophors by short-wave UV light. The pharmacokinetics
      of the 2-[4-(4'-chlorophenoxy)-phenoxy]-propionic acid (HCG 004) serves as an
      example to demonstrate the usefulness of this method; reference is also made to
      analogously successful studies of other drugs.

PMID- 1037264
TI  - The effect of etafenone on the subcellular distribution of calcium and some
      oligoelements in heart muscle. Ultracytochemical and x-ray microanalytical study.
AB  - In order to detect the subcellular localization of calcium in the myocardium of
      laboratory animals (rats and guinea-pigs) under the influence of 2'-(2
      diethylaminoethoxy)-3-phenyl-propiophenone (etafenone, Baxacor) (4 mg, 20 mg and
      100 mg/kg body weight) two ultracytochemical methods, with lead acetate and with
      potassium pyroantimonate, were used. In addition, X-ray microanalysis of
      myocardial fragments was performed. The correlation of ultrastructural,
      ultracytochemical and X-ray microanalytical findings provides direct evidence of
      the hypothesis that etafenone acts on myocardium as a so-called "calcium
      antagonist". The subcellular targets of etafenone action are mainly the
      sarcoplasmic reticulum and mitochondria. Etafenone modifies also the
      concentration of copper, zinc and selenium in myocardium. The effect of etaferone
      on myocardial calcium and oligoelements appears to be dose-dependent.

PMID- 1037265
TI  - Oscillations and cysteine metabolism in aortic strips of hypertensive rats.
AB  - Aortic strips of normal and hypertensive rats were used for the study. In
      comparison with normal rats hypertensive rats show a low cysteine and high
      homocysteine level and vascular auto-oscillations. The auto-oscillations are
      damped by cysteine, cAMP, theophylline and heparin but not by ADP.

PMID- 1037266
TI  - [On the mode of action of heptaminol (author's transl)].
AB  - The effect of heptaminol, an aliphatic amine with an alcoholic group on carbon 2,
      on sympathetic nerves and on isolated chromaffine granules was infestigated. In
      cats, heptaminol caused long-lasting, dose-dependent pressor effects accompanied
      by tachycardia and contractions of the nictitating membrane. In comparison with
      tyramine, heptaminol was 100 times less potent in increasing blood pressure and
      10 times less effective in inducing contractions of the nictitating membrane. The
      rise in blood pressure as well as tachycardia and contraction of the nictitating
      membrane were diminished by cocaine. After pretreatment with cocaine, heptaminol
      in high doses caused short-lasting depressor effects. Also in rats the pressor
      effect of heptaminol was weaker but of longer duration than that of tyramine. The
      dose-response curve was depressed by pretreatment with reserpine. The tachycardia
      induced by heptaminol was markedly diminished after pretreatment with reserpine.
      After repeated injections heptaminol reduced the norepinephrine content of the
      rat heart by 20-40%, Tyramine and hexylamine were more effective than heptaminol
      in depleting the norepinephrine stores of the heart (50-60%). In fluorescence
      microscopic investigations on sympathetic nerves (rat iris) depleted of
      norepinephrine by reserpine, the uptake of alpha-methylnorepinephrine could be
      inhibited or prevented by heptaminol. The spontaneous release of catecholamines
      from isolated bovine chromaffine granules was enhanced (+30%) by heptaminol or
      methamphetamine in high concentrations. In lower concentrations, however, both
      drugs reduced the uptake of 14C-epinephrine in isolated medullary granules by 20
      40%. In addition a non-specific papaverine-like spasmolytic effect of heptaminol
      could be demonstrated. The results suggest that heptaminol exerts its
      pharmacological action by interfering with release and uptake of norepinephrine.

PMID- 1037267
TI  - Vasodilator profile of a new 1,4-dihydropyridine derivative, 2,6-dimethyl-4-(3
      nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N
      methylamino)]-ethyl ester 5-methyl ester hydrochloride (YC-93).
AB  - A new 1,4-dihydropyridine derivative, 2,6-dimethyl-4-(3-nitrophenyl)-4,4
      dihydropyridine-3,5-dicarboxylic acid 3-[2-(N-benzyl-N-methylamino)]-ethyl ester
      5-methyl ester hydrochloride (YC-93), when i.v. injected into anesthetized dogs,
      exhibited not only a greated vasodilation in both cerebral and coronary than in
      femoral vessels, but also about 100 to 300 times higher potency as well as longer
      durability than any of reference drugs such as isoxsupurine, papaverine and
      cinnarizine. YC-93 was also effective in vasodilation by i.m. and i.d.
      administration. When administered into vertebral and coronary arteries, YC-93
      caused vasodilation at the doses that did not affect systemic blood pressure. YC
      93 did not potentiate the vasodilator effect of adenosine, and vasodilation by YC
      93 was influenced by neither propranolol, atropine, diphenhydramine nor
      aminophylline. Acute toxicity (LD50) of YC-93 was almost the same as that of
      papaverine in mice and rats. Thus, YC-93 is a potent bu low-toxic vasodilator
      agent acting preferentially and perhaps directly on cerebral and coronary
      vascular beds and is well absorbed from gastrointestinal tract into blood stream.

PMID- 1037268
TI  - [Comparative studies in vivo and in vitro on the formation of phenolic biphenyl
      metabolites in various animal species (author's transl)[].
AB  - The enzymatic hydroxylation of biphenyl in the liver microsome fractions of
      rabbits, guinea pigs and rats has been studied. They hydroxylated biphenyls were
      detected by thin-layer and gas chromatography. By the aid of gas chromatography
      all the hydroxybiphenyls could be quantitatively determined simultaneously. The
      following results were obtained: 1. 3-Hydroxybiphenyl, 3,4-dihydroxybiphenyl and
      4,4'-dihydroxybiphenyl were detected along with the already known biphenyls with
      hydroxy groups in o- and p-positions. 2. Beside the prevailing p-hydroxybiphenyl,
      the m-hydroxy derivative was found in greater amounts than the o-hydroxybiphenyl.
      3. The ratios of the amounts of the individual biphenyl metabolites versus one
      another varied with the animal species. Differences were shown among both young
      and old animals within a single species. With rats, the hydroxylation pattern was
      found to depend on the race. 4. Orientation studies of the conjugate fractions of
      rabbits and mice fed with biphenyl indicated that, in addition to the metabolites
      mentioned, the glucuronosides of 2-, 3- and 4-hydroxybiphenyl and 4,4'
      dihydroxybiphenyl could be detected in urine.

PMID- 1037269
TI  - Effect of hexachlorophene on the coagulation process in beagle dogs.
AB  - In a dermal toxicological study the effect of hexachlorophene on the blood
      coagulation process in dogs over a period of 12 weeks was investigated. The
      thrombelastographic results revealed a reduction in reaction time, coagulation
      time and an increase in maximal amplitude supplemented with subsequent increase
      in the number of platelets and the enhancement of ESR.

PMID- 1037270
TI  - Xanthine oxidase activation in animal liver during infectious processes. Short
      communication.
AB  - A relevant increase in xanthine oxidase in the liver was constantly found in the
      couse of the study of enzyme variations in infected mice. This effect seems to be
      due to bacterial toxins and not related with microbial pathogenicity. Xanthine
      oxidase is suspected to play a role in host defence mechanisms.

PMID- 1037271
TI  - New hepato-protective agents. I. Maleopimaric acid-4alpha-carboxamides.
AB  - A number of amide derivatives of maleopimaric acid were synthesised and
      preliminary results on their protective activity against galactosamine-induced
      liver damage in the rat are described. The compounds (2, 6, 9 and 15) were found
      to display the highest level of protective activity producing significant
      lowering of serum GOT and GPT levels at a daily dose of 250-300 mg/kg. The LD50
      of these compounds was typically in excess of 2000 mg/kg.

PMID- 1037272
TI  - New hepato-protective agents. II. Maleopimaridyl morpholides.
AB  - A further series of derivatives of maleopimaric acid, the maleopimaridyl
      morpholides, has been prepared and results on their protection against
      galactosamine-inducted liver damage in the rat are described. The compounds (3,
      4, 8 and 10) were found to display the highest levels of hepato-protective
      activity in the series. Compound 8 (LD50 greater than 10 g/kg) which exhibited
      significant, dose-related protection at a daily dose in the range of 50-400
      mg/kg, was selected for detailed investigation.

PMID- 1037273
TI  - Preliminary studies on the absorption, distribution and excretion of N-(2
      hydroxyethyl)-maleopimarimidyl morpholide (3H-RU 18492) in the female rat and
      dog.
AB  - Following the oral administration of 3H-labelled N-(2-hydroxyethyl)
      maleopimarimidyl morpholide (3H-RU 18 492) to rats and dogs, radioactivity was
      detected in plasma and the various tissues examined. However, the major fraction
      of the dose remained unabsorbed and the highest concentrations of radioactivity
      were found in the liver. In both species the major route of excretion of
      radioactivity was via the bile.

PMID- 1037274
TI  - The protective effect of a novel compound RU 18492, on galactosamine-induced
      hepatotoxicity in the rat.
AB  - A novel compound N-(2-hydroxyethyl)-maleopimarimidyl morpholide (RU 18 492), was
      investigated for its effect against galactosamine induced hepatitis in rats. It
      was found to be active in reducing both serum transaminase levels and
      morphological changes due to the hepatotoxin. The protection was shown to be dose
      related and a significant reduction in liver damage was seen at doses of 50-400
      mg/kg p.o. RU 18 492 was ineffective against carbon tetrachloride induced
      hepatitis in rats. It was suggested that the protective effect of RU 18 492 was
      due to its ability to stimulate the smooth endoplasmic reticulum thus inducing a
      more rapid detoxification of galactosamine.

PMID- 1037275
TI  - [The effect of tri-iodinated contrast media on acetylcholinesterase of human
      erythrocytes (author's transl)].
AB  - The side effects of water soluble iodinated contrast media often mimic the
      clinical picture of acetylcholine intoxication. This prompted us to determine the
      amount of inhibition of human acetylcholinesterase by the following contrast
      media in vivo and in vitro: methyl glucamineiodipamide (Biligrafin forte),
      methylglucamine iothalamate (Conray 60), sodium-iothalamate (Conray 80). In vivo
      no correlation could be found between clinically manifest adverse reaction and
      enzyme inhibition after contrast media application. The in vitro values for 50%
      inhibition of erythrocyte acetylcholinesterase are: methylglucamine-iodipamide:
      0.036 M, methylglucamine-iothalamate: 0.158 M, sodium-iothalamate: 0.3 M. Since
      in vitro, the maximal inhibitory effect of a given dose of contrast media can
      only be registered after a time interval when most of the contrast media in vivo
      has already been excreted by the kidneys or extracted by the liver, it seems very
      improbable that the enzyme inhibition seen in vitro should have any consequence
      whatsoever under clinical conditions. The in vitro inhibition of
      acetylcholinesterase is quickly reversible, with nearly all the activity regained
      15 min after the removal of the contrast media.

PMID- 1037276
TI  - [Studies on the absorption of benzilic acid esters of homologous dimethyl-(2
      hydroxyethyl)-alkylammonium bromides through buccal mucosa. 5th communication: On
      optimum bioavailability of homologous quaternary ammonium compounds (author's
      transl)].
AB  - Distribution studies in vitro predict increasing absorption rates in vivo with
      increasing distribution coefficients up to a limiting value. Buccal absorption
      tests with homologous, quaternary cholinesterbromides of benzilic acid do not
      confirm this hypothesis. The reasons could be the rather hydrophilic properties
      of the mucosal membranes and thus adsorption of drug to the mucosa. The
      evaluation of results with undissociated homologous carboxylic acids, however,
      shows a good correlation between the prediction from in vitro studies and the
      buccal absorption test.

PMID- 1037277
TI  - [Changes in hemodynamics and contractility during supraventricular tachycardias
      and after electrical or aprindin-induced termination (author's transl)].
AB  - Alterations of hemodynamics and contractility were studied in 6 patients in whom
      two consecutive runs of supraventricular tachycardias (SVT) were electrically
      induced. Following initiation there was an abrupt decrease of arterial blood
      pressure, left ventricular systolic pressure, dp/dtmax, cardiac index and stroke
      work index (SWI). These parameters -- with the exception of SWI -- increased in
      the course of the SVT, however, control values were not reached. Mean pulmonary
      artery pressure steadily increased and remained on an elevated level until the
      tachycardia was stopped. When the SVT was electrically terminated, there was a
      transient overshoot of mean arterial and left ventricular systolic pressure,
      while mean pulmonary artery pressure slowly returned to control values. When the
      tachycardia was stopped by i.v. infusion of N-)diethylamino-3-propyl)-N-phenyl
      indanamine-2 (aprindin, Amidonal) -- started at the 7th minute -- there was no
      statistically significant difference, neither during the SVT nor after cessation
      as compared to the values of the first run. Only mean pulmonary artery pressure
      remained at a higher level after SVT was stopped. It may, therefore, be concluded
      that in patients with otherwise normal hearts aprindin applied in a dosage
      sufficient to stop the SVT, does not exhibit noteworthy inotropic side effects.

PMID- 1037278
TI  - [Studies on the bioavailability of the individual components from a combination
      of dilazep and beta-acetyldigoxin (author's transl)].
AB  - Original tablets of Cormelian [= 50 mg 1,4-bis[3-(3,4,5-trimethoxybenzoyl-oxy)
      propyl]-perhydro-1,4-diazepine (dilazep)] and Cormelian-Digotab (= 50 mg dilazep
      + 0.2 mg beta-acetyl-digoxin) were produced with 3H-dilazep as prescribed in the
      special galenic technique. After application of a single oral dose of two tablets
      dilazep to 9 patients serum concentration was analysed at different times up to
      24 h p.a.; the renal excretion rate of dilazep and metabolites was determined up
      to 48 h. Two tablets of the combination were given to 4 of these patients 4 days
      after application of dilazep and the corresponding analysis were repeated; in the
      serum of these patients the concentration of glycoside was determined by
      radioimmuno assay. The following results were obtained. 1. Differences in serum
      concentrations and renal excretion rates of dilazep and metabolites were not
      observed after application of the mono- and combination product. In comparison to
      results after oral application of pure dilazep in gelatin capsules the serum
      concentrations 1 h after application of Cormelian and Cormelian-Digotab were
      statistically significantly higher. With reference to comparable total absorption
      rates these results may be representative for a possibly retarded absorption rate
      of dilazep given as pure substance. An influence of the different galenic
      techniques on the intensity and direction of metabolites could not be
      substantiated. 2. By large dispersions of the single values high absolute and
      relative concentrations of beta-acetyl-digoxin were found in the serum of all the
      4 patients after application of combination. Contrary to two commercial products,
      applied to each of 10 test persons under comparable conditions, statistically
      higher serum concentrations of glycoside were analysed 1 h after application of
      the combination. The results of these studies confirm a positive influence of the
      galenics on the biological availability of both the components in the combination
      drug Cormelian-Digotab.

PMID- 1037279
TI  - [Sputum viscosity and pulmonary function measurements during a one-week
      parenteral treatment with a standardized oxidation product of oil of turpentine
      and terpin hydrate].
AB  - In 23 patients with chronic obstructive lung diseases, viscosity, airway
      resistance, arterial blood gases and acid-base balance, and sputum aspect were
      measured before and after one-week treatment with Ozothin, a substance from
      oxidation products of ol. terebinth. and terpinum hydratum. Within this time,
      viscosity of the sputum was reduced, airway resistance decreased, and arterial
      oxygen pressure slightly increased, whereas arterial carbon dioxide tension
      obvious change of sputum aspect could be observed. Correlation calculations
      revealed no significant relations between viscosity and the above cited lung
      function values. The results indicate that administration of Ozothin may liquefy
      viscous secretion and reduce sputum viscosity.

PMID- 1037280
TI  - [Clinical experience with metered aerosol of beclometasone in patients with
      obstructive lung disease (author's transl)].
AB  - 142 patients suffering from chronic obstructive lung disease were treated with 9
      chloro-11beta,17,21-trihydroxy-16beta-methyl-pregna-4,4-diene-3,20-dione-17,21
      dipropionate (beclometasone) metered aerosal. Between 3 subgroups: chronic
      infectious obstructive lung disease, allergic obstructive lung disease and
      chronic bronchitis without airway obstruction, there was no difference in the
      results. Three times per day three puffs of the metered aerosol can substitute
      about 6 mg prednisolone p.o. The systemic effects of the beclometasone therapy
      with metered aerosols are clearly less than those which are seen with a
      comparable oral dosage. Side effects are seen dose dependently as hoarseness and
      as relatively harmless Candida infection of the throat. For most of the patients
      with obstructive lung disease who are dependent on glucocorticosteroids
      beclometasone as metered aerosol should be given as basic therapy. In case higher
      dosages are necessary they should be given orally or parenterally.

PMID- 1037281
TI  - [Experimental study on the tracking behaviour with a view to differentiating the
      effects of an antidepressant in various doses compared to placebo (author's
      transl)].
AB  - In a double-blind cross-over study 15 highly motivated, healthy male subjects
      (Ss), aged from 23 to 29 years, were given 200 mg and 400 mg p-methoxy
      phenoxyaceticacid-diethylaminoethylamide-hydrochloride (mefexamide) and a
      placebo. On each of the three days the Ss were tested in different tracking
      devices and the integrated absolute error was measured in the tests of a duration
      of three hours each. Influences of practice, leading to unwanted and disturbing
      effects were excluded by a preceding period of four training sessions on
      different days. The main result of the investigation was that performance in
      tracking was ambivalent. The single dosage (200 mg mefexamide) caused small
      improvements in tracking in the range of about 5%. These differences from placebo
      partly could be determined to be significant at the level of 5% compared to
      placebo. The double dosage (400 mg mefexamide) deteriorated tracking performance
      significantly (5%-and partly 1%-level, two-tailed test) in the range of about 10%
      on the average. Differences in performance between the two dosages were
      correspondingly larger and could be determined at a higher level of significance,
      too.

PMID- 1037282
TI  - [Comparative studies on oral glucose tolerance and serum lipids under the
      influence of a new oral contraceptive (SH B 209 AB: 2 mg cyproterone acetate +
      0.05 mg ethinyl estradiol), the combination D-norgestrel/ethinyl estradiol and in
      a control group (author's transl)].
AB  - 24 healthy women given the combination of cyproterone acetate (2 mg) + ethynyl
      estradiol (0.05 mg) [SH B 209 AB] and D-norgestrel (0.25 mg) + ethinyl estradiol
      (0.05 mg) [Neogynon] were compared with a control group in oral glucose tolerance
      tests. The volunteers were divided into three groups. Two received alternately
      both preparations with each treatment cycle preceded by one cycle without
      medication. The third group served as an independent control. On the 25th day of
      each cycle blood was withdrawn before and 15, 30, 45, 60, 90 and 120 min after
      the carbohydrate load. Blood glucose and insulin and free fatty acids in serum
      were determined. Fasting values of triglycerides and cholesterol in serum were
      determined. The following results were obtained: 1. The mean fasting levels of
      blood glucose, serum insulin and free fatty acids were unchanged. 2. The total
      area under the blood glucose curve over the initial value was not altered 2 h
      after treatment with SH B 209 AB or Neogynon. The total area under the insulin
      and free fatty acids curves were also unchanged after the oral glucose load. 3.
      There was no change in serum cholesterol. 4. Serum triglycerides were
      significantly increased after SH B 209 AB. 5. The implications of the structural
      differences between both gestagens are discussed.

PMID- 1037283
TI  - [Studies on the regulation of blood lipids by pulmonary tissue].

PMID- 1037284
TI  - Quantitative cell culture biocompatibility testing of medical devices and
      correlation to animal tests.
AB  - The biocompatibility of a wide variety of biomaterials was quantitatively
      assessed, in a physiologically normal environment" as to cytotoxicity induced in
      WI-38 cells by cell culture medium extracts. Materials tested included PVC
      plastic, rubber, silicone rubber, polyethylene, polypropylene, acetal,
      polyurethane, Teflon, nylon, epoxy, and polystyrene. Cell culture test results
      were correlated to U.S.P. animal tests. Potential test artifacts, lead, barium,
      cadmium, and endotoxin were tested for cytotoxicity in WI-38 cells. Cell culture
      methods yielded more positive tests, particularly rubber, PVC plastic and
      silicone rubber compounds, than observed in U.S.P. animal tests. Positivity in
      animal tests did not correlate quantitatively to cytotoxic titers in cell
      culture. Discrepancies between cell cultures tests and animal tests, specifically
      rubber compounds, were attributable, in some instances, to differentials in
      elution efficiency between saline, cottonseed oil, and complete MEM cell culture
      medium. In other instances, particularly PVC plastics, differences between cell
      culture and animal test results were due to an inherent difference in the two
      indicator systems to respond to specific toxic moieties.

PMID- 1037285
TI  - [Prevention and treatment of endocrine exophthalmos].

PMID- 1037286
TI  - Phase II trial of cytembena in patients with advanced ovarian and breast cancer.
AB  - Thirty women with histologically proven advanced ovarian or breast cancer were
      treated with cytembena. Of nine patients with ovarian cancer and 21 with breast
      cancer none had worthwhile objective remissions. Cytembena was given at a dose of
      250 mg/m2/day for a course of 5 days repeated at weekly intervals. Improvement,
      particularly relief of pain from skeletal metastases, was observed in 16 of the
      patients; an additional seven patients had stable disease while treated with
      cytembena. Cytembena has no hemopoietic toxicity, but nausea and vomiting and an
      "autonomic storm" phenomenon are dose-limiting factors. Further studies
      incorporating this drug in combination regimens seem warranted.

PMID- 1037287
TI  - [Determination of ketophenylbutazone in the blood serum by means of gas
      chromatography].

PMID- 1037288
TI  - Immunological aspects of inflammatory bowel disease.

PMID- 1037289
TI  - [A case of juvenile chondritis dissecans].

PMID- 1037290
TI  - EMS in the '70s: an approach to their development through training.

PMID- 1037291
TI  - 'Good education is good management'.

PMID- 1037292
TI  - Reaching out to the community: a cooperative health study program.

PMID- 1037293
TI  - Computer matches towns with health workers.

PMID- 1037294
TI  - Evaluating a disaster plan the hard way.

PMID- 1037295
TI  - Management training: a homespun program.

PMID- 1037296
TI  - A nursing management workshop for new supervisors.

PMID- 1037297
TI  - Increasing the visibility of the nurse in teaching of patients.

PMID- 1037298
TI  - Management development for hospitals: the CHC experience.

PMID- 1037299
TI  - Making health education work.

PMID- 1037300
TI  - New employees negotiate contract for orientation.

PMID- 1037301
TI  - Shared services organization communicates via cable TV.

PMID- 1037303
TI  - Make employee benefits come alive!

PMID- 1037302
TI  - Sharing educational services: an organizational model.

PMID- 1037304
TI  - Videotape or videocassette--which should you use?

PMID- 1037305
TI  - Applying andragogy to patient education.

PMID- 1037306
TI  - The impossible becomes possible--through cooperation.

PMID- 1037307
TI  - Acute effects of tolamolol on renal function in hypertensive patients.
AB  - The renal heamodynamic effects of a single i.v. administration of tolamolol were
      studied in 9 hypertensive subjects. No change of GFR and ERPF was observed after
      tolamolol, while urine output decreased and urine creatinine concentration
      increased. A reduction of the heart rate was confirmed. Blood pressure was
      unchanged.

PMID- 1037308
TI  - The use of drugs for behavior modification as it relates to the practice of
      optometry--Part I.
AB  - Medications used in behavior modification can result in untoward side effects,
      including ocular and visual changes. As in many other aspects of health care,
      optometrists can serve as the first line of defense to guard their patients
      against permanent damage from side effects they may not associate with use of
      their medication. Optometry's responsibility and role in management of side
      effects is delineated. Areas of behavior modification of concern to optometrists
      are discussed. These include: (1) learning problems and mental retardation; (2)
      mental disorders, menopause, and alcoholism; and (3) drug abuse.

PMID- 1037309
TI  - Clinical hematological progression of hereditary lymphosarcoma in rabbits.
AB  - Considerable diversity exists in the clinical progression data for lymphosarcoma
      both between and within species. Thirty-four rabbits with hereditary
      lymphosarcoma were used to define the clinical progression of this condition
      under controlled genetic conditions. Changes in the erythropoietic cells of the
      rabbit hemogram in cases of hereditary lymphosarcoma (ha/ha) follow a fairly well
      defined clinical course of about one-and-one-half months duration. Data are
      presented showing that these changes are subsequent to schanges in the
      granulocytic cells of the leukocyte series both peripherally and in the bone
      marrow.

PMID- 1037310
TI  - [Effect of products of erythrocyte destruction on the activity of the renal
      erythropoietic factor--erythrogenin].

PMID- 1037311
TI  - [Clinico-morphological characteristics of surgically removed thyroid gland of the
      residents of Primorskii territory].
AB  - The authors carried out a histological study of 150 thyroid glands removed for
      various forms of goiter. Nodular and mixed goiter with frequent signs of
      degeneration prevailed in residents of the Primorsk region. Histological
      structure of the majority of them corresponded to the colloidal, mostly to the
      macrofollicular goiter. A lower percentage of morphological signs of the goiter
      activity in comparison with the clinical data revealed in the hospitalized
      patients can be attributed to the efficacy of antithyroidal therapy causing
      involution of the hyperactive glands. Various types of adenomas chronic
      thyroiditis and the initial stages of the node malignization were determined only
      by histological examination.

PMID- 1037312
TI  - Sensitivity of various gamma-ray detectors to 252Cf neutrons in free air.

PMID- 1037313
TI  - Determination of trace amounts of mercury in water by neutron activation analysis
      with lubricating base oil as extractant.
AB  - This paper deals with a convenient method in the determination of trace amounts
      of mercury in water. After being irradiated with neutrons, water sample was
      treated with 7.0M HCIO4 solution and mercury was extracted with lubricating base
      oil. In such a simple operation, the sensitivity can reach 10(-8)g Hg/4ml H2O.

PMID- 1037314
TI  - Interaction of radionuclides with organic matter dissolved in seawater.
      Interaction of radiocobalt with some amino acids.
AB  - The interaction of radiocobalt with glycine, alanine or aspartic acid dissolved
      in seawater was investigated by means of adsorption on Chelex 100, solvent
      extraction with dithizone or gel filtration chromatography. Although the
      distribution coefficients of Co on Chelex 100 decreased gradually with ageing
      even in the absence of organic matter, much more decreases were observed in the
      presence of the amino acids. The distribution coefficients on the resin reached
      equilibrium states in about 20 days. The extraction of cobalt with dithizone in
      carbon tetrachloride was also inhibited in the presence of the amino acids.
      Alanine and aspartic acid showed a similar interfering tendency in both
      adsorption on Chelex 100 and dithizone extraction, while glycine inhibited
      dithizone extraction more than adsorption on Chelex 100. From the fractionation
      of Co by Sephadex G-10 gel filtration chromatography, the higher molecular
      species of Co associated with the amino acids occurred after several days ageing
      and then increased together with decreasing in the lower molecular species.

PMID- 1037315
TI  - [Particle size determination by radioisotope x-ray absorptiometry with
      sedimentation method].
AB  - The possibility of radioisotope X-ray absorptiometry to determine the particle
      size of powder in conjunction with sedimentation was investigated. The
      experimental accuracy was primarily determined by Cow and X-ray intensity. where
      Co'=weight concentration of the particle in the suspension
      w'=(micron/rho)l/(mu/rho)s-rhol/rhos rho; density micron/rho; mass absorption
      coefficient, suffix l and s indicate dispersion and particle, respectively. The
      radiosiotopes, Fe-55, Pu-238 and Cd-109 have high w-values over the wide range of
      the atomic number. However, a source of high micron value such as Fe-55 is not
      suitable because the optimal X-ray transmission length, Lopt is decided by the
      expression, micronlLopt approximately 2/(1+C'ow') by using Cd-109 AgKX-ray
      source, the weight size distribution of particles from the heavy elements such as
      PbO2 to light elements such as Al2O3 or flyash was determined.

PMID- 1037316
TI  - [Analysis of errors in radiation relay. (I) Optimum setting of time constant].
AB  - The statistical error of liquid level controlled by radiaiton relay is analysed
      and a method of minimizing the error is proposed in this paper. This method comes
      to the problem of optimum setting of the time constant of radiation relay. The
      equations for obtaining the value of time constant are presented and the
      numerical results are shown in a table and plotted in a figure. The optimum time
      constant of the upper level control relay differs entirely from that of lower
      level control relay.

PMID- 1037317
TI  - [New method of anatomic localization of scintigram of various organs by
      simultaneous combination of emission scanning and transmission scanning].
AB  - When the photoscintillo-roentgenography is used for relating the scintigram of
      internal organs to the anatomic structures, this method is found to have some
      defects--the difference of magnification between the emission scan and the
      roentgenogram, the inaccuracy due to the geometric distortion of the X-ray image,
      the impossibility of the simultaneous photographing of the scan and the X-rays,
      etc. Then, to diminish the influence of these defects we improved on the
      photographic recording system of a dual-heal scanner, and made use of the
      transmission scanning method. That is, we combined the recording parts, Ch1 and
      Ch2, into one system, using Ch1 for the light source of transmission scan and Ch2
      for that of emission scan. In this way, we managed to make the two incident rays
      from those light sources converge into a focus upon a film. Thus we could perform
      a simultaneous emission-transmission scanning, by moving, at the same time in the
      same direction, the scanning detector over the patient and the small radioactive
      source (241Am) under him. This method can be applied to any radioactive nuclide
      to be used in transmission scanning and emission scanning. As the result of
      applying this method clinically in our department, the method has proved to be
      very useful for anatomic localization.

PMID- 1037318
TI  - [Activity measurement of 3H, 14C in air (author's transl)].

PMID- 1037319
TI  - An automatic 14CO2-collecting apparatus.

PMID- 1037320
TI  - [Basic and clinical evaluation of thyroxine radioimmunoassay kit. II: RIAMAT T4
      kit (author's transl)].

PMID- 1037321
TI  - [Application of charged particles to surface layer analysis--ion backscattering
      method (author's transl)].

PMID- 1037322
TI  - [Tests on transport packaging for radioactive materials. (II) (author's transl)].

PMID- 1037323
TI  - [Detection of 13C tracers by NMR spectroscopy and its application (2) (author's
      transl)].

PMID- 1037324
TI  - [Changes in body composition before, during and after open heart surgery].

PMID- 1037325
TI  - [Consequences of arterial surgery].

PMID- 1037326
TI  - [Consequences of the surgery of large intestine].

PMID- 1037327
TI  - [Vagotomy in gastroduodenal ulcer. Methods and results].

PMID- 1037328
TI  - [Postoperative pancreatides. Clinical studies and pathogenetic prospects].

PMID- 1037329
TI  - [Consequences of thyroidectomy].

PMID- 1037330
TI  - [Lymphokines: soluble mediators of the cellular immunity in vitro and in vivo].

PMID- 1037331
TI  - [Immunological problems in diabetes mellitus].

PMID- 1037332
TI  - [LATS and other thyroid-stimulating immunoglobulins in the pathogenesis of
      Basedow's disease].

PMID- 1037333
TI  - [Immunological surveillance and aspecific immunotherapy in neoplastic diseases].

PMID- 1037334
TI  - [Immunological aspects of celiac disease].

PMID- 1037335
TI  - [Gastrc cancer: An epidemiologic and dietary study in 100 patients and 100
      controls (author's transl)].

PMID- 1037336
TI  - [Quality of production--daily attention].

PMID- 1037337
TI  - Drug treatment of venereal disease: analysis of 273 cases in Ghana.
AB  - The presence of non-gonococcal urethritis, resistant to penicillin therapy was
      noted by Ikejiani in Nigeria as early as 1955. This syndrome is now known as non
      specific urethritis, or non-specific genital infection in the female. Sarrat
      (1973) has shown the effectiveness of penicillin plus probenecid, specti nomycin,
      and cotrimoxazole in male cases of gonorrhoea in Dakar. Sogbetun and Osoba (1974)
      have shown the effectiveness of metronidazole in trichomoniasis in males in
      Nigeria. Our study was made on a mixed University population of 2,700 students
      seen in one clinic during the year 1975. There were 273 cases of sexually
      transmitted diseases including gonorrhoea, non-specific urethritis or genital
      disease, trichomoniasis and chronic urethritis or vaginitis. Treatment of
      gonorrhoea with penicillin alone or with spectinomycin was only 50% effective.
      But good results were obtained with penicillin plus probenecid or penicillin plus
      cotrimoxazole. Good results were obtained in non-specific urethritis, or non
      specific genital disease, when tetracycline or its derivatives were used. Good
      results were obtained in the treatment of trichomoniasis with metronidazole in
      males and females. It was concluded that in gonorrhoea penicillin should be given
      (in adequate dosage) with probenecid or cotrimoxazole. Spectinomycin should be
      used at a dose level of 4 g instead of 2 g. The management of chronic urethritis
      and vaginitis was very difficult. The drug treatment of venereal disease in Ghana
      has not revealed any unique characteristics except, perhaps, an increased
      resistance of the gonococcus to spectinomycin.

PMID- 1037338
TI  - [Architecture of collagen fibers in the meniscus of the human knee joint, with
      special reference to the medial meniscus and its connection to the articular
      ligaments].
AB  - 1. To understand the meniscus-tears the architecture of their collagenic fibers
      is of interest, particularly so the connection of the fibers of the medial
      meniscus with the collateral ligament. 2. The ligaments of 12 knee joints have
      been studied macroscopically and with the aid of thick serial sections under
      polarized light. 3. The main portion of the tibial collateral ligament passes the
      articular space without any connection with the capsule or the meniscus. The
      upper oblique portion of the ligament runs inside the external zone of the
      meniscus to the posterior attachment of the latter. Immediately inferior to the
      articular space the oblique fibers have another attachment. 4. The findings in
      respect of the arrangement of the fibers in the menisci differ from those in
      earlier studies. Only in the external zone the fibers run approximately parallel
      to the outer border. After leaving the external zone the fibers run in an arched
      way through the middle zone. In the internal zone these fibers have nearly a
      radial direction. 5. The architecture of the menisci is discussed under
      functional aspects. It does not correspond to a "spring" but to a tendon, which
      is extended over a hypomochlion. 6. Forms and localisations of meniscus-tears
      have been discussed under viewpoint of architecture and compared with clinical
      results: The typical tear of the posterior segment of the medial meniscus is the
      horizontal cleavage. The present opinion according to which longitudinal tears
      are the typical meniscus lesion, seems to be doubtful.

PMID- 1037339
TI  - [Instructional work according to the new programs].

PMID- 1037340
TI  - [Leukemoid reaction (author's transl)].

PMID- 1037341
TI  - [Implication of ferritin in hematology].

PMID- 1037342
TI  - Several problems concerning red cell membranes.

PMID- 1037343
TI  - Pathophysiology of red cell lipids.

PMID- 1037344
TI  - [Morphology and metabolism of the blood platelet. Introduction].

PMID- 1037345
TI  - [Platelet aggregation and its morphological change induced by concanavalin A and
      collagen (author's transl)].

PMID- 1037346
TI  - [Platelet morphology and function--adhesion, aggregation and release reaction
      (author's transl)].

PMID- 1037347
TI  - [Membrane structure and functions of human platelets (author's transl)].

PMID- 1037348
TI  - [Platelet nucleotide metabolism and platelet function (author's transl)].

PMID- 1037349
TI  - [Platelet glucose metabolism and its function--energy dependency of fresh- and
      fixed-platelets in aggregation and clot retraction-- (author's transl)].

PMID- 1037350
TI  - [Lipid metabolism of the platelet and platelet function (author's transl)].

PMID- 1037351
TI  - [Hairy cell leukemia (author's transl)].

PMID- 1037352
TI  - [Role of laboratory in the diagnosis of hairy cell leukemia (author's transl)].

PMID- 1037353
TI  - [Hairy cell leukemia: diagnostic criteria from the clinical point of view
      (author's transl)].

PMID- 1037354
TI  - [Hairy cell leukemia with special references to the relation to allied disorders:
      from the pathological stand point (author's transl)].

PMID- 1037355
TI  - [Hairy cell leukemia: in relation to the allied disorders (author's transl)].

PMID- 1037356
TI  - [Hairy cell leukemia. Studies on the nature of hairy cells (author's transl)].

PMID- 1037357
TI  - [Hairy cell leukemia of B-lymphocyte nature: demonstration of monoclonal surface
      IgG (author's transl)].

PMID- 1037358
TI  - [HLA B8 and Graves' disease (author's transl)].
AB  - HLA typing has been carried out in 100 caucasions with Graves' disease and
      compared with 270 healthy controls. 25 HL-A antigens were characterized using a
      lymphocytotoxicity micro-technique. Analysis of the results reveals an increased
      incidence of HLA-B8 antigen (35% in patients as compared to 16.3% in controls)
      with a high degree of statistical significance: p = 0.0002 and corrected p (X 25)
      = 0.005. We did not observe a clear-cut correlation between the presence of HLA
      B8 and different characteristics of the disease: sex, age of onset, familial
      history, exophtalmia, goiter, severity. The knowledge of the relationships
      between the HLA B8 gene and several auto-immune diseases is a strong argument in
      favor of the auto-immune nature of Graves' disease. The association between HLA
      B8 and Graves' disease could be explained by a close linkage between the second
      HLA locus and one or several Ir-IrG loci, occupied in predisposed individuals by
      "predisposing" alleles. In these subjects, an antigenic contact with an exogenous
      etiological agent would induce a pathological immune response, with production of
      thyroid stimulating IgG.

PMID- 1037359
TI  - [Bromocriptine therapy in acromegaly (author's transl)(proceedings)].

PMID- 1037360
TI  - [Therapeutical effects of bromocriptine in 10 acromegalic patients: study of
      somatotrophic function and glucose tolerance test (author's
      transl)(proceedings)].

PMID- 1037361
TI  - [Bromocriptin treatment of acromegaly (author's transl)(proceedings)].

PMID- 1037362
TI  - [Treatment of acromegaly by dibromoergocryptine and cyproheptadine (author's
      transl)(proceedings)].

PMID- 1037363
TI  - [Results of CB 154 in the treatment of acromegaly in France (author's
      transl)(proceedings)].

PMID- 1037364
TI  - [Cytologic study of a malignant lymphoma of primary breast localization].

PMID- 1037365
TI  - Effect of posture on the presence of fat in tracheal aspirate in neonates.

PMID- 1037366
TI  - Immunosuppressive drug therapy as a potentiator of skin tumours in five patients
      with lymphoma.

PMID- 1037367
TI  - Poldine iontophoresis in the treatment of palmar and plantar hyperhidrosis.

PMID- 1037368
TI  - Congenital and acquired heart diseases: (A survey of 7062 persons).
AB  - A survey was carried out amongst 7062 people of different age groups in Dacca
      city and in a village. It was found that 207 (2.92%) persons had some sort of
      heart disease. Hypertension was present in 83 (1.10%) persons. Rheumatic heart
      disease, ischaemic heart disease and cardiac arrhythmia were detected in 53
      (0.75%), 24 (0.33%) and 16 (0.22%) persons respectively. Congenital heart disease
      was found in 13 (0.18%) individuals, and 18 (0.25%) persons were suffering from
      cardiomypathy or corpulmonale. Rheumatic heart disease was common in poor people
      of younger age. More ischaemic heart disease was found in well-to-do people but
      poor people were not immune from this.

PMID- 1037369
TI  - Studies on the nutritional status of expectant mothers and newborn babies.
AB  - Heights, weights, haemoglobin, total proteins and albumin-globulin (A/G) ratio of
      157 pregnant women in their last trimester of pregnancy are reported along with
      heights, weights, haemoglobin and albumin-globulin ratio of newborn babies. The
      results have been discussed.

PMID- 1037370
TI  - Echinococcosis in cattle and goats.
AB  - In the 500 cattles examined, 90 (18%) had hydatid cysts in one or more organs
      whereas only 12(2.4%) goats, out of 500 had the disease. This is considered to be
      due to shorter period of longevity and age of slaughter of goats compared to
      catte. Since dog is an important definitive host responsible for the spread of
      echinococcosis, a survey on the incidence of hydatid cyst in dogs is necessary
      from public health point of view.

PMID- 1037371
TI  - Experience with norethisterone enanthate as injectable contraceptive.
AB  - Norethisterone Enanthate (NE) was used in 151 women as injectable contraceptive.
      Pregnancy due to method failure was 2% whereas the overall pregnancy was 4%. The
      results have been discussed.

PMID- 1037372
TI  - Effects of norethisterone enanthate on certain body functions.
AB  - Effects of Norethisterone Enanthate (an injectable contraceptive) on body weight,
      blood pressure, blood cell count, level of haemoglobin, fasting blood sugar and
      serum cholesterol were studied in 31 women. It was observed that in the
      successful acceptors the pregnancy rate was nil. No appreciable change could be
      found in the body functions studied.

PMID- 1037373
TI  - Non-association of ABO blood groups with diabetes mellitus in Bangladesh.
AB  - Confirmed diabetics (2312) were tested for ABO blood groupings and the results of
      frequency compared with normal (8936) subjects. The data were analysed
      statistically to detect any possibility of an association between ABO blood
      groups and diabetes mellitus. No such association is apparent in the subjects
      studied.

PMID- 1037374
TI  - Cancer of male breast. (A report on incidence).
AB  - During a retrospective study of 1843 patients with malignant lesions, 83 were
      identified as breast cancer. Of these, 4 turned out to be male breast cancer
      showing a male to female ratio of this neoplasms to be 1:19.7.

PMID- 1037375
TI  - Peptic ulcer: (Analysis of predisposing and associated causes).
AB  - Age incidence, food habits and socio-economic condition were studied in a series
      of 478 predominantly male peptic ulcer patients. Age incidence of peptic ulcer
      increased in the second decade of life, reached a peak at the third decade and
      tapered off towards the end of fourth decade. As many as 57% of the patients
      belonged to the low socio-economic group and 78% were having only two meals a
      day. A ratio of 21 : 1 for duodenal ulcer to gastric ulcer was revealed from
      laparotomy findings.

PMID- 1037376
TI  - Malignant diseases. (A review of 115 cases).
AB  - A review of 115 malignant lesions (proven histologically) is presented. Good
      number of malignant lesions were found confined to female sex organs.

PMID- 1037377
TI  - Hypertension in a mixed community.
AB  - Casual blood pressure was studied in a mixed community above 20 years of age and
      records of hospitalised patients for hypertension and/or its complications were
      analysed. It was found that about 2 percent of people examined were unaware that
      they had elevated blood pressure. High incidence of hypertension was found in the
      age group of 40-50 years in the hospitalised patients.

PMID- 1037378
TI  - [Effect of 2-bromo-alpha-ergocryptine on the response of the hypothalamo
      hypophyseal-adrenal system to insulin hypoglycemia in man].

PMID- 1037379
TI  - [Endocrine effects of bromocryptin in patients with Parkinsonism].

PMID- 1037380
TI  - [Modifications of the incretory pituitary response of prolactin to sulpiride
      after treatment with bromocryptin].

PMID- 1037381
TI  - Current concepts in drug therapy. (21) Bromocriptine "Parlodel" (Sandoz).

PMID- 1037382
TI  - [Isolation of Thogoto virus from Amblyomma and Boophilus ticks in Central
      Africa].
AB  - A survey has been carried out in the Cameroons and the Central African Republic
      about the role of the ticks in the ecology of arboviruses in Central Africa.
      Attempts for virus isolation were made for 12,678 Amblyomma variegatum, 3,276
      Boophilus decoloratus and 1,769 Boophilus annulatus, by inoculation into suckling
      mice. From 968 pools which were inoculated, 20 yielded isolates which were
      identified to Thogoto virus. Considering previously published results concerning
      tick-borne virus isolations in the Central African Republic, it appears now that
      five arboviruses are present in the ticks in central Africa : Dugbe, Jos and
      Thogoto (in A. variegatum, B. decoloratus and B. annulatus), Bhanja (in A.
      variegatum) and Chf. Congo (in Hyalomma nitidum).

PMID- 1037383
TI  - [Favus of newborn infants].

PMID- 1037384
TI  - [Report on first 2 cases of rhinosporidiosis in Cameroon].
AB  - The authors report the first two cases of rhinosporidiosis in Cameroon. The
      patients were females from Cameroon southern-center or littoral areas, damp
      regions, and presented a conjunctival localization of this mycosis.

PMID- 1037385
TI  - [Kala-Azar in the Republic of Chad. 6 year survey at the Central Hospital of
      N'Djamena (Fort-Lamy)].

PMID- 1037386
TI  - [Significance of passive hemagglutination and its prospectives in lymphatic
      filariasis].
AB  - The authors analyze the data concerning 219 sera, that they have tested in
      passive hemagglutination, with as antigen a Dirofilaria immitis proteic extract,
      in French Polynesia. Besides its light sensitivity, this method does appear very
      interesting. It points out: --First, that there is a gaussian distribution of the
      results found at various dilutions, both by "filarian" and "non filarian" people.
      Therefore, this distribution is a feasible and practical parameter for evaluation
      of the Filariasis transmission in different populations. --On the other hand,
      that there is an inverse correlation between the presence of microfilaria in the
      blood and the level of immunological response for lymphatic Filariasis.

PMID- 1037387
TI  - [Activity of levamisole (Solaskil) in lymphatic filariasis caused by Wucheria
      bancrofti (variety pacifica].
AB  - A 6 mg./kg. daily dose of levamisole was given during three days to ten carriers
      of microfilarias Wuchereria bancrofti in Tahiti. No action against adult worms
      was noticed. The immediate microfilaricid action was at least equivalent to the
      action of DEC. However the decrease of microfilaremia was not so long with
      levamisole than with DEC given to a lower dose. Lastly the amount of reactions
      after a treatment by levamisole is notable.

PMID- 1037388
TI  - A new blackfly (S. (W.) golani n. sp. (Diptera, Simuliidae)) from the Eastern
      Mediterranean basin.
AB  - S. (W.) golani n. sp. Beaucournu-Saguez and Braverman is described from material
      collected in the Golan region, Israel (35degrees42' E, 32DEGREES57' N). It is
      related to S. (W.) paraequinum Puri 1933 but is distinguished by the morphology
      of the pupal respiratory filaments and by details of the structure of the male
      genitalia.

PMID- 1037389
TI  - [Rapid detection of hemoglobinopathies S by tude tests].

PMID- 1037390
TI  - [Australia antigen carriers in Martinique].

PMID- 1037391
TI  - [Hemolytic effect of niridazole in G6PD deficient persons].

PMID- 1037392
TI  - [Basedowien optic neuritis, cured by Ogura's operation].

PMID- 1037393
TI  - Bromocriptine in the treatment of advanced breast cancer.

PMID- 1037394
TI  - [2 cases of benign- giant-cell tumor of the knee meniscus (anatomo-clinical
      contribution)].

PMID- 1037395
TI  - [Medicamentous ablactation post partum. Comparative study between bromocryptin
      (Parlodel) and methallenoestrol (Vallestril) as well as 2 combination variants of
      both preparations].

PMID- 1037396
TI  - Karyometric study of benign and malignant diseases of the thyroid gland.
AB  - The results of the karyometric measurements in different thyroid diseases (both
      benign proliferative processes and cancer) have shown that this method may be
      useful in differential diagnosis of these diseases. It was also found that there
      are evident differences between the shapes of histograms in various forms of
      cancer. The shape of the histogram depends not only on the histological structure
      of the tumour (follicular, papillary, undifferentiated cancer), but also on the
      type of the cells of which it consists (A,B or C cells).

PMID- 1037397
TI  - [On the present status of pulmonary tuberculosis in the Japanese leprosy hospital
      -a mass survey for it at the National Leprosarium Oku Komyo-en in 1975 (author's
      transl)].

PMID- 1037398
TI  - [On the middle lobe syndrome (author's transl)].

PMID- 1037399
TI  - [Electrocardigraphic study at the National Leprosarium Kuryu Rakusen-en on the
      high land, Gunma, Japan (author's transl)].

PMID- 1037400
TI  - [Treatment of Parkinson's disease with bromocriptine].

PMID- 1037401
TI  - [Rapid determination of 137Cs in environmental samples--purification of 137Cs by
      ammonium molybdophosphate column separation].
AB  - A rapid method for the determination of 137Cs in environmental samples was
      proposed. The principal technic employed in this study is based on column
      separation of 137Cs using ammonium molybdophosphate mixed with glass fiber to
      eliminate contribution of natural radionuclides such as 40K and 87Rb. The
      separation of cesium from potassium and rubidium was performed by the elution
      with 0.5m ammonium nitrate solution. The time required for separation of cesium
      was five hours as compared with the conventional cation exchange separation which
      required thirteen hours. The chemical yield of cesium carrier was normally more
      than 90 percent. The results obtained were compared with that by the conventional
      methods using Bio-Rex cation exchange separation and the good agreement between
      the two methods was obtained.

PMID- 1037402
TI  - [Experimental and clinical studies on the accuracy of geometry-independent
      counter].
AB  - For the purpose to conduct precise geometry-independent radioassay of large
      biological samples, the authors constructed an apparatus with the "peak+scatter"
      counting method slightly modified from that of Gibbs, et al. and studied its
      accuracy from the basic and clinical aspects. The apparatus, an opposed-head
      counter, consisted of two matched 2 x 2-in. NaI crystal detectors and
      photomultipliers that were connected in parallel to a pulse-height spectrometer.
      The crystal faces were separated by 54 cm. The detectors were enclosed in 5cm
      thick shield built with lead and the sample chamber was a 15 cubic cm-box type of
      3 mm-thick Lucite. A 13 cmphiX7.7 cm styrene topper container was used for the
      sample container. It was found that the relation of primary gamma energy of six
      radioisotopes and geometry-independent counting threshold turned out to be
      linear. The assay accuracy with 131I was about +/- 5% in fluid samples
      irrespective of its sizes (up to 500 ml) or homogeneity. In solid samples the
      accuracy approached that of fluid by the addition of water up to the height of
      it. The range, in which the activity could be measured within 5% error
      originating from statistical fluctuations or loss of counts due to instrument
      dead time, proved to be about 34 approximately .06 micronCi with 57Co in assay
      time of 10 min. On the basis of the basic investigations, the geometry
      independent counting was used for the radioassay of stool and urine. Since the
      assay could be done simply up to a relatively large volume without need of
      material adjustment, it served well in the assay of urine and stool of clinical
      practice as well as in animal radioassay.

PMID- 1037403
TI  - [Advantages, disadvantages and selection methods of thyroxine measurement-
      comparison of CPBA and RIA].
AB  - Although recent progress in radioimmunoassay (RIA) permitted direct RIA for
      thyroxine (T4), there appeared few reports evaluating clinical applicability of
      T4 RIA as routine method. The authors evaluated advantage, disadvantage of
      methods for T4 measurement in comparison between CPBA (competitive protein
      binding analysis) and RIA, and tried to discuss about selection of methods for T4
      measurement. Res-O-Mat T4 was chosen as CPBA, and RIAMAT-T4(St) and T4-RIAKIT(Sp)
      were chosen as RIAs. Detailed descriptions about both RIA methods appeared
      elsewhere [2, 3]. From the basic experiments, reproducibility of CPBA, St and Sp
      within assay were 5.8% (C.V.), 4.0% (C.V.), and 8.5%(C.V.) respectively, and mean
      recovery rates were 92.2%, 100.7% and 96.1% respectively. T4 value measured by
      both RIAs correlated well with CPBA, and St showed slightly lower value and Sp
      showed slightly higher value than CPBA. The normal ranges for RIAs were 3.7-11.7
      microng% (St) and 4.6-15.2 microng% (Sp). Diagnostic accuracy for hyperthyroid
      state were 83.3% (CPBA), 85.7%(St) and 69.2% (Sp), and for euthyroid state were
      92.0% (CPBA), 98.8% (St) and 95.7% (Sp). The diagnostic accuracy for hypothyroid
      state in three methods were lowest. From the economical point of view, cost
      performance, time performance and total time for single assay were analysed and
      mathematical equations were obtained from actual assay by each methods. When the
      number of samples per single assay was less than 10, CPBA was most economic in
      terms of cost and time performance and total time required. In the assay of more
      than 20 samples, RIAs were efficient in each point of views. In the point of view
      of sample volumes required, RIAs were most promising. The authors concluded that
      guides for selection of methods in T4 assay were as follows: A) CPBA was most
      efficient in local use especially when less than 10 samples were frequently to be
      assayed. B) RIAs were efficient in batch processing more than 20 samples,
      especially in automated laboratories.

PMID- 1037404
TI  - [Study on tumor affinity of technetium-99m-labeled radiopharmaceuticals. (2)
      99mTc-Sn-diphosphonate (99mTc-EHDP), 99mTc-Sn-dimercaptosuccinic acid (99mTc
      DMSA), and 99mTc-Sn-diethyl stilbestrol diphosphate (99mTc-DSDP)].
AB  - The authors have examined the tumor affinity of various 99mTc-labelled
      radiopharmaceuticals to Ehrlich's tumor for the purpose of delineating positively
      human malignant neoplasm. This paper includes biologic distributions of 99mTc-Sn
      diphosphonate (99mTc-EHDP), 99mTc-Sn-dimercaptosuccinic acid (99mTc-DMSA) and
      99mTc-Sn-diethyl stilbestrol diphosphate (99mTc-DSDP, 99mTc-Honvan) as the second
      report on the tumor affinity to the Ehrlich-bearing mice. (a) Tumor concentration
      of 99mTc-EHDP was lowest and the positive delineation of implanted tumor with
      99mTc-EHDP was poorest in sequential images, though the active accumulation to
      some soft tissue maglinant neoplasms, the breast cancer and the thyroid cancer,
      has been reported. (b) Tumor concentration and tumor to blood ratio of 99mTc-DMSA
      were not so high on the contrary of our expectation that 197Hg-DMSA may show the
      high tumor concentration and the high tumor to blood ratio like 197Hg
      chlormerodrin as same renal scanning radiopharmaceuticals. (c) Tumor
      concentration of 99mTc-DSDP was highest. Tumor to blood concentration ratio,
      however, was lower than that of the above mentioned radiopharmaceuticals but
      tumor to liver ratio and/or tumor to lung ratio was over 1.0 at the earlier time.
      Biologic distribution of 99mTc-DSDP was similar to that of 32P labeled DSDP and
      then it is presumed that 99mTc is labeled at phosphate ester of DSDP which is
      dephospholytated immediately by phospholylase in vivo following the intravenous
      injection. Therefore, it may be assumed that the accumulation mechanism of 99mTc
      DSDP to Ehrlich's tumor is related to the phospholylase activity in neoplasms but
      is not known precisely.

PMID- 1037405
TI  - [Affinity of the elements in group VI of the periodic table to tumors and
      organs].
AB  - In order to investigate the tumor affinity radioisotopes, chromium (51Cr),
      molybdenum (99Mo), tungsten (181W), selenium (75Se) and tellurium (127mTe)--the
      elements of group VI in the periodic table--were examined, using the rats which
      were subcutaneously transplanted with Yoshida sarcoma. Seven preprarations,
      sodium chromate (Na251CrO4), chromium chloride (51CrCl3), normal ammonium
      molybdate ((NH4)299MoO7), sodium tungstate (Na2181WO4), sodium selenate
      (Na275SeO4), sodium selenite (Na275SeO3) and tellurous acid (H2127mTeO3) were
      injected intravenously to each group of tumor bearing rats. These rats were
      sacrificed at various periods after injection of each preparation: 3 hours, 24
      hours and 48 hours in all preparations. The radioactivities of the tumor, blood,
      muscle, liver, kidney and spleen were measured by a well-type scintillation
      counter, and retention values (in every tissue including the tumor) were
      calculated in percent of administered dose per g-tissue weight. All of seven
      preparations did not have any affinity for malignant tumor. Na251CrO4 and
      H2127mTeO3 had some affinity for the kidneys, and Na275SeO3 had some affinity for
      the liver. Na2181WO4 and (NH4)299MoO4 disappeared very rapidly from the blood and
      soft tissue, and about seventy-five percent of radioactivity was excreted in
      urine within first 3 hours.

PMID- 1037406
TI  - [Biological fate of 3H-labeled penfluridol. (3) Correlation between concentration
      of 3H-penfluridol in the brain and its anti-methamphetamine activity].
AB  - The Penfluridol (PFL) is a potent and long-acting neuroleptic belonging to the
      diphenylbutyl piperidine series. The purpose of the present study is to
      investigate a correlation between the brain concentration of unchanged 3H-PFL and
      its neuroleptic activity in the methamphetamine-antagonism test. The experimental
      animal comprised adult male Wistar rats weighing about 200 g. All the rats were
      administered 3H-PFL orally and killed at appropriate times after administration.
      After killing blood samples were collected and the brain and liver were excised.
      The blood was extracted with 4 volumes of ethanol. The brain and the liver were
      homogenized in 9 volumes of ethanol. The amount of 3H-PFL in the ethanol extract
      was determined by thin-layer chromatography. The result showed that the drug
      level in the brain was relatively constant when the dose was the median effective
      dose (ED50) for the test at those time intervals after administration.

PMID- 1037407
TI  - Determination of platinum in optical glasses by substoichiometric neutron
      activation analysis.

PMID- 1037408
TI  - Solubility of 210Po contained in airborne dusts.

PMID- 1037409
TI  - A study on separation of 99Mo from neutron-irradiated UO2 by precipitation as
      ammonium molybdophosphate.

PMID- 1037410
TI  - Evaluation of 99mTc-phytate as radiopharmaceutical.

PMID- 1037411
TI  - [Study of the efficiency on multi-format camera (author's transl)].

PMID- 1037412
TI  - [Fundamental consideration of tetrasorb-E kit for determination of thyroxine in
      human sera (author's transl)].

PMID- 1037414
TI  - [Measurement of 15N-tracer and its application in mass spectrometry (1) (author's
      transl)].

PMID- 1037413
TI  - [Tests on transport packaging for radioactive materials (III) (author's transl)].

PMID- 1037415
TI  - [Metabolism of skin and changed induced by drugs, toxins and physical agents].

PMID- 1037416
TI  - [Recent aspects of the physiopathology of Reed-Sternberg cells, with special
      reference to their relations to lymphatic tissue].

PMID- 1037417
TI  - [Chemical composition and protein value of some baby foods (author's transl)].
AB  - The determination of lipids, available carbohydrates and unavailable
      carbohydrates, and of various minerals has been carried out on some baby foods;
      the value of the protein fraction has been similarly determined by the
      ultrafiltration method of the enzymic hydrolisate in vitro. Both the total
      protein content and the essential amino acid availability of the foodstuffs are
      satisfactory although generally speaking a slight decrease of the protein value
      has been found in this material as compared to the crude samples, due
      particularly to the breakdown of sulfur-containing amino acids. This breakdown is
      due probably to the high temperature reached during the technological processes
      at industrial level.

PMID- 1037418
TI  - [Influence of rapeseed oil on lipoprotein lipase activity in pigs (author's
      transl)].
AB  - Toxic activities in various animal species have shown for rapeseed oil. In this
      paper the influence of this oil on lipoprotein lipase activity of heart, liver
      and lung of pigs has been examined. The animals were fed with rapeseed oil with
      40% erucic acid for 7, 15, 20 and 40 days. The control animals received olive
      oil. The results have shown a slight increase in the lipoprotein lipase activity
      in the heart of the pig after 20 days with rapeseed oil. In the liver this
      increase is particularly large in the pigs having been fed for 15 days both with
      rapeseed oil and olive oil. No differences were observed in the lung in the test
      and control animals with the only exception of animals fed for 20 days.

PMID- 1037419
TI  - [Adaptation to a rapeseed oil enriched diet as shown by the mitochondrial
      oxidation rate in the heart (author's transl)].
AB  - 40 wistar rats were divided into two groups which had been fed one year earlier a
      diet in which 30% of the caloric intake consisted of rapeseed oil and peanut oil
      respectively. Both groups were then fed a diet of 30% peanut oil for five months
      and then fed a normal diet for seven months. At this time each of the two main
      groups was subdivided into four smaller groups, each group receiving a different
      diet: one of 25% rapeseed oil, one of 25% peanut oil, one of 25% butter, and one
      internal control group. At the end of the experiment the rats were sacrificed by
      decapitation. One portion of each heart was used for measuring its fatty acid
      content and the remaining portion was used for preparing sarcosomes on which the
      exigen consumption was measured polarographically. It was found that no erucic
      acid was present in the hearts of the rats fed rapeseed oil one year previously,
      and then then refed the same diet in the present experiment. The mitochondrial
      respiratory activity of the treated rats did not show any significant difference
      with respect to the found in the control groups, unlike the first experiment.

PMID- 1037420
TI  - [Poly-protein. II--Precipitation of proteins from alfalfa juice by cationic
      polyacrylamide (author's transl)].
AB  - This note reports some experimental results on the preparation of leaf protein
      concentrates (LPC) from alphalpha juice by means of polyelectrolites, according
      to Poly-Protein Process. The pilot plant is described with its working
      conditions, and the yield and the chemical composition of the products (pressed
      alphalpha, juice, green LPC and brown juice) are reported. In particular 50
      liters of juice, obtained by pressing 100 kg of fresh alphalpha, gave 1.6 kg of
      green LPC (on a dry weight basis). The product so obtained has a high protein
      content (56.2%) and represents a particularly valuable product for its several
      prospective uses in the feed industry.

PMID- 1037421
TI  - [Research on some phosphorganic insecticide residues in olive oil in relation to
      techniques of Dacus oleae control. I. Results of total treatment to the foliage
      (author's transl)].
AB  - The research conducted to verify the presence and the amount of residues of
      organophosphorus insecticides in olive oil from olive trees sprayed against.
      Dacus oleae has shown that both hydrophilic (dimethoate, formathion,
      phosphamidon) and lypophilic (fenthion, medathion, prolate) substances tested
      leave more or less appreciable residues in the oil, either in a short time or in
      more than one month from the treatment. In the operative conditions reflecting
      antidacic practice, the amount of residue appears higher for the lypophilic
      organophosphorus insecticides.

PMID- 1037422
TI  - [Use of infrared radiations in the freeze-drying of foods (author's transl)].
AB  - Use of near infrared radiation as heating source in freeze drying of food
      products, appear to be interesting both for the efficiency of the process and for
      its economical aspect. In the present paper the results obtained in freeze drying
      runs with heating plates and I.R. radiations are described. The obtained results
      show that: with increasing trays load of product, the I.R. system is more
      efficient than the traditional one; the product quality obtained is higher for
      I.R. radiation, especially with higher tray loads; the heat flux output of the
      I.R. system is much lower than the one of the heating plates, at the same level
      of subliming water.

PMID- 1037423
TI  - Effects of gamma irradiation on onion sprouting. I.--Influence of dose rate and
      post-harvest period of treatment.
AB  - Onions of "Dorata di Parma" variety were exposed to 10 Krads of Co60 gamma
      irradiation in 5, 10, 20, 40, and 80 minutes in December, 1975 and then stored in
      the cold storage (10 +/- 1 degree C; R.H. 65-70%) and at the room temperature (15
      20 degrees C; R.H. 40-70%) for 3 months, to study the influence of dose-rate and
      post-harvest period of treatment. Average number of buds sprouted in each onion
      bulb under cold storage condition ranged from 2-3, while this number was found to
      increase to 3-4 under ambient storage conditions. Although no effect of either
      irradiation or dose rate was observed when onions were irradiated after the break
      of their dormancy, however, a significant slowing down effect of irradiation
      could be observed as far as the rate of growth  of sprouts was concerned. Weight
      loss was also reduced significantly in the irradiated onions as compared with
      controls.

PMID- 1037424
TI  - [T.L.C. separation and capsaicin evaluation in red peppers (author's transl)].
AB  - Capsaicin is extracted from dried powdered pepper by 2-propanol in Soxhlet,
      separated by TLC on Silica gel, developing with petroleum ether (40-60 degrees C
      PB), chloroform and acetonitrile (40:45:15) mixture and spectrophotometrically
      estimated at 280nm. The method appears to be accurate and suitable for routine
      analysis.

PMID- 1037425
TI  - [Determination of soft wheat in semolina and in alimentary pasta by
      electrophoretic and immunological methods].

PMID- 1037426
TI  - Lactose malabsorption in Thai infants and children: effect of prolonged milk
      feeding.
AB  - More than one-third of Thai infants were lactose malabsorbers soon after birth
      and the percentage of lactose malabsorption increased with age. Beyond 4 years of
      age, all Thai children studied were lactose malabsorbers. Continued milk
      supplementation over the study period did not affect the ability to digest
      lactose in the amount given in the load test. Since the milk-supplemented group
      of children tended to have better weight gain and few undesirable
      gastrointestinal symptoms, it seems milk feedings can be used to advantage even
      among populations with a record of high lactose intolerance.

PMID- 1037427
TI  - [CB 154 in the treatment of Parkinson's disease. Results in combination with L
      dopa and decarboxylase inhibitor].

PMID- 1037428
TI  - Experimental analysis of the specific and aspecific activity of tolamolol (dl-UK
      6558)

PMID- 1037429
TI  - [Effects of viquidil on the electric and mechanical activity of smooth muscle].

PMID- 1037430
TI  - An overview of venereal disease programs in Britain, West Germany, Denmark, and
      Sweden, with implications for Canada.

PMID- 1037431
TI  - [Presence of free-living amoebae in urban and communal water-supply systems of
      the Brest area].
AB  - During a preliminary study, from October 1975 until June 1976, we tried to find
      free-living limax amoebae in the waters proceeding from 6 systems which partly
      cover the wants of Brest and its bay (Finistere). From the 32 analysed samples,
      19 were positive, of which 10 were able to grown at the first at 37 degrees C.
      The free-living amoebae belong to 3 genus: Harmanella, Vahlkampfia and
      Acanthamoeba. We have not found Naegleria species.

PMID- 1037432
TI  - [Amoebecide and trichomonacide activities of secnidazole in the laboratory].
AB  - A study of the experimental chemotherapeutic activity of secnidazole as compared
      to metronidazole is presented, including a summary of toxicity, metabolism,
      pharmacokinetic studies and preliminary results from clinical trials. Secnidazole
      is about twice as active as metronidazole against experimental amebiasis,
      equiactive against trichomoniasis, and possesses low toxicity. After oral
      administration to man, active concentrations in the blood persist much longer
      than in the case of metronidazole and notably longer than for tinidazole. In the
      clinic, its therapeutic activity against hepatic amebiasis seems to be at least
      equal to that of metronidazole; it appears also to be more active against acute
      intestinal amebiasis, and specially more effective against E. minuta and cyst
      carriers. Against vaginal trichomoniasis it was as effective as metronidazole
      after repeated administration for several days, and the percentage recovery rate
      was as high after one single dose as after daily administration. The digestive
      tolerance seems to be very satisfactory. In view of these findings, the
      advantages which secnidazole might possess over other 5-nitroimidazoles already
      in use for the treatment of amebiasis and trichomoniasis are discussed.

PMID- 1037433
TI  - [Study on a focus of ascaridiasis in a locality of Cap Bon (Tunisia)].
AB  - The study of ascaridiasis in a single locality of the Cap Bon region (Tunisia)
      where prevalence of this helminthiasis is much higher than anywhere else in the
      region, shows that 71,1% of the population is infected and all ages approximately
      in the same proportion. This high prevalence can be explained by a cumulative
      effect of two transmission factors: a particular construction of houses, which
      have a kind of reservoir for organic wastes in direct connection with the street,
      and the use of human excrements in agriculture. Mass chemotherapy every 3 months
      during several consecutive years is proposed.

PMID- 1037434
TI  - [Presence of Angiostrongylus cantonensis in the Reunion Island. Isolation of the
      strain].
AB  - The detection of some cases of eosinophilic meningitis suggest that
      Angiostrongylus cantonensis is present in Reunion Island. Larvae of this nematode
      have been isolated after dissection of Achatina fulica and have been used to
      infest laboratory rats. 30 days later, the dissection of these animals shows the
      presence of young worms in the brain and in the pulmonary arteries. 45 days
      later, first-stage larvae are recovered from the feces of animals. Now, the
      strain is maintained in Biomphalaria glabrata and in the rat.

PMID- 1037435
TI  - [French Guiana and bilharziasis].
AB  - The authors discuss about the lack of bilharziasis in French Guyana and report
      the experimental infestation of Biomphalaria glabrata coming from Cayenne with a
      porto-rican strain of Schistosoma mansoni.

PMID- 1037436
TI  - Behaviour of two acid hydrolases in Fasciola hepatica during in vitro survival.

PMID- 1037437
TI  - [Evolution of filarial hemagglutinating antibodies 1 year after a single dose of
      diethylcarbamazine].
AB  - The authors compare the serological results obtained before and after a single
      dose with diethylcarbamazine (6 mg./kg.) in a homogeneous and strongly infected
      with Wuchereria bancrofti var, pacifica population. They point out a
      statistically significant decrease of the hemagglutining antibody titres of
      filarian patients.

PMID- 1037438
TI  - [Mobile edema of the face and neck followed by intraocular localization of
      Gnastosoma spinigerum].
AB  - The authors report the first case observed in Cameroon of an intraocular
      localization of the nematode Gnastostoma spinigerum. The course of about 3 months
      presented three phases. The first one consisted of pains in the right
      hypochondrium, with scapulalgia during three weeks, probably correlated with the
      crossing of the digestive wall and intraocular migrations. The second phase
      consisted of ambulatory oedema in the face and neck during three weeks. The last
      phase consisted of a localization of the parasite in the right eye anterior
      chamber. After three weeks' observations the surgical extraction of a living
      gnastostoma larva was carried out. The biological signs were an increase of the
      sedimentation rate, hyperleucocytosis with marked eosinophilia during the first
      two phases of the disease. These symptoms became normal after the ocular
      localization. From the functional point of view the result was better than
      foreseen.

PMID- 1037439
TI  - [Human sparganosis. Report of a probable 7th case in South America and review of
      the subject].
AB  - A case of human Sparganosis was found in a resident of Northern Argentina, Pozo
      del Tigre, Province of Formosa, a zone bordering with the Republic of Paraguay,
      with a histopathologic diagnosis realized in the Pathologic Anatomy Institute of
      Asuncion. In the Republic of Paraguay Dyphyllobrotium has been observed in cats,
      which reveals the existence of intermediaries (rats, water snakes, birds, etc.)
      as sources of human infection. Northern Argentina, where the patient always
      lived, is a geographic zone similar to the Republic of Paraguay. This case is the
      first described in the inland zone of the continent (and probably the seventh
      case in the Southamerican continent). The patient's profession, called "tropero"
      (cowherd), required that he had close contact with the land or a habitual
      exposure to nature, which does not exclude the probability of infection related
      to the patient's professional habitat.

PMID- 1037440
TI  - [Significance of the skin allergy test in the diagnosis of strongyloidiasis].

PMID- 1037441
TI  - The effect of minocycline, doxycycline and oxytetracycline on experimental mouse
      toxoplasmosis.
AB  - This is a comparative study of the effect of oral and parenteral administration
      of oxytetracycline, doxycycline and minocycline on experimental acute
      toxoplasmosis in mice. Two different inocula were used. All the antibiotics were
      ineffective orally. Doxycycline and minocycline were effective intraperitoneally,
      curing 90% of the mice who received the smaller inoculum. However, cerebral cysts
      of T. gondii were more common in the survivors treated with doxycycline.

PMID- 1037442
TI  - [Comparative study of bases for suppositories].

PMID- 1037443
TI  - A comparison of the dissolution and bioavailability characteristics of three
      spironolactone tablet formulations, including preliminary data on two
      spironolactone metabolites.
AB  - The bioavailabilities of three spironolactone tablet formulations specially
      selected for major differences in in vitro dissolution tests were compared in
      normal male volunteers by measuring plasma and urinary levels of the
      pharmacologically active spironolactone metabolite canrenone. It was possible to
      demonstrate small but statistically significant differences in plasma canrenone
      concentration-time curves derived from the three formulations together with
      significant differences in the time course of urinary canrenone excretion. The
      bioavailabilities of the three formulations did not differ significantly although
      the tablet with the poorest in vitro dissolution produced a significant delayed
      peak canrenone concentration. The dissolution rate methodology and results are
      described and an approach to the development of improved in vitro dissolution
      tests for spironolactone is suggested. The use of a new method for canrenone
      estimation resulted in the incidental detection of two other quantitatively
      significant spironolactone metabolites and preliminary information is given on
      these.

PMID- 1037445
TI  - Recognition of lactose intolerance.
AB  - Evidence has been accumulating that except where dairying has been carried on for
      centuries, postweaning inability to digest milk is the norm for humans as well as
      other land mammals. Given the ethnic diversity of the U.S., there may well be 30
      million Americans who cannot drink milk without developing symptoms and many
      instinctively learn to avoid it. A simple lactose tolerance test is described
      that establishes the diagnosis.

PMID- 1037446
TI  - Treatment of meningeal leukemia.
AB  - Chemotherapy via the intrathecal and intraventricular routes with the use of up
      to three drugs plus radiotherapy have produced remissions so prolonged that it is
      now practical to think of a "cure" rather than simple palliation of this disease.
      A promising treatment protocol is described in which radiotherapy is combined
      with and followed by intraventricular methotrexate and cytosine arabinoside.

PMID- 1037447
TI  - In Papua New Guinea, health aides carry medical burden.

PMID- 1037448
TI  - The pharmacist: gatekeeper of the community's health.

PMID- 1037449
TI  - FDA problems with medications in the marketplace: I.

PMID- 1037450
TI  - Growth rate, feeding practices, and dietary intake of Thai infants under two
      years old in central Bangkok.
AB  - There is a growth retardation among Thai infants under the age of two years in
      the Bangkok area. A serious matter is the possible delay in brain development
      which may start at this early stage. In comparing growth curves of infants on
      three patterns of feeding it appears that those having sweetened condensed milk
      suffer from malnutrition and possible delay in brain development. Breast feeding
      provides satisfactory growth rate and brain development up to the age of 12
      months and there is great hope that a nutrition programme to encourage breast
      feeding could combat existing problems of protein energy malnutrition. There is
      evidence of greater deficiency of energy than of protein, and there is need to
      investigate whether growth retardation is due to inadequate energy intake or to
      high infection rates or to both. Rice is the most suitable basic food for
      supplementing infants diets, and uncooked grain giving 1 g protein and 83.68 kJ
      (20 kcal) may well be the simplest formula for supplementing feeding up to the
      age of two years.

PMID- 1037451
TI  - [Radioautographic and cytofluorimetric analysis of DNA synthesis during the pre
      implantation period of rat and mouse embryonic development].
AB  - The patterns of DNA synthesis and kinetics of cell population in the rat and
      mouse embryos were studied by means of 3H-thymidine autoradiography and
      cytofluorimetry. The rat and mouse embryos during the period of cleavage consist
      of a heterogenous population of blastomeres. At all the stages under study, all
      phases of the cell cycle occur in the blastomeres: G1, S, G2 and mitosis. The
      embryonic cells were distributed into groups containing 2c, 3c, 4c and more DNA.
      The ratio of cell number in these groups differed in the mouse and rat embryos.
      The mouse embryos are characterized by the appearance of a considerable amount of
      polyploid cells in S phase at the morula stage. The stage and species specific
      quantitative and qualitative patterns were established for DNA synthesis and
      kinetics of the cell population of blastomeres.

PMID- 1037452
TI  - [Experimental study of the biology of the miracidium of Philophthalmus rhionica
      Tichomirov, 1976 (Trematoda, Philophthalmidae)].
AB  - Some peculiarities of the biology of miracidia of Philophthalmus rhionica have
      been studied: penetration of the parasite's eggs into the environment, hatching
      of larvae, the miracidia motion, their life span and changes in the invasion
      ability character in time.

PMID- 1037453
TI  - [Enuresis and behavior disorders in children. Treatment with butriptyline as the
      only therapeutic treatment].

PMID- 1037454
TI  - Low molecular weight organic acids as inhibitors of kinin-forming activity of a
      rodent tumor acid protease and human plasma kallikrein.

PMID- 1037455
TI  - Control of food intake in the lactating rat: role of suckling and hormones.

PMID- 1037456
TI  - [Relation between seminal fructose and spermatogenic activity].

PMID- 1037457
TI  - [Analysis of 308 cases of sterile couples at the Human Reproduction Service of
      the Associao Maternidade de Sao Paulo].

PMID- 1037458
TI  - [Mechanism of anemia in autoimmune disorders; I. Clinical hematological studies
      of anemia in autoimmune disorders, regarding to sideroblasts, ferrokinetics and
      red cell survival time (author's transl)].

PMID- 1037459
TI  - [Mechanism of anemia in autoimmune disorders; II. Relationship betweein iron
      kinetics and isoferritins in bone marrow cells of hematological diseases
      (author's transl)].

PMID- 1037460
TI  - [Effects of chloramphenicol (CP) on in vitro colony-forming cell (CFU-C) in W
      anemic mice (author's transl)].

PMID- 1037461
TI  - [A case of IgE myeloma (author's transl)].

PMID- 1037462
TI  - [Chromosome studies in patients with immunoglobulin abnormalities. Part I.
      Immunoglobulin deficiencies(author's transl)].

PMID- 1037463
TI  - [Chromosome studies in patients with immunoglobulin abnormalities. Part II.
      Benign and malignant monoclonal gammopathies (author's transl)].

PMID- 1037464
TI  - [Ultrastructural change of human erythrocyte membrane through the solubilization
      (author's transl)].

PMID- 1037465
TI  - The effects of treatment with enzymatic preparations and tannin phenolic
      absorbent agents in extracting the olive oil by single pressure process on the
      oil yield, on the analytical characteristics of the oils of the vegetation waters
      and of the waste waters.
AB  - The vegetation waters of the must, the oils and the waste waters extracted from
      olive pastes, treated by enzymatic preparations (Cellulase, Hemicellulase,
      Polygalacturonase and Protease) and tannin phenolic adsorbent agents (Polyclar
      AT, Methylcellulose, Albumine) employed during crushing of olive were analysed:-
      the vegetation waters in order to justify some technological results (oil yields
      and extraction speed) obtained by the treatments;--the oils in order to examine
      the effects of the treatments on the same chemical characteristics and the
      stability to rancidity. --The waste waters to verify the possible influence of
      the treatments on the BOD. From the results relative to the vegetation waters, it
      has been suggested that the increase of the "detached oil" does occur by two
      different biochemical mechanisms which involve the constitutive lipoprotein of
      the oil drop membrane and colloidal constituents of the liquid and solid phase of
      the pastes. For what concerns the oils, the treatments induce the slight
      modification of the fatty acid composition and chromatic characteristics, a
      higher stability to rancidity, a qualitative and quantitative increase of the
      "headspace" violates constituents above oils. The waste waters obtained from the
      olive pastes show lower BOD5 values.

PMID- 1037466
TI  - Simultaneous purification of mitochondrial and cytoplasmic isozymes of aspartate
      aminotransferase from beef kidney.
AB  - Mitochondrial and cytoplasmic isozymes of aspartate transaminase are separated
      from beef kidney homogenates by ammonium sulfate fractionation. The mitochondrial
      isozyme is purified essentially as described earlier (Eur. J. Biochem., 1972, 26,
      196-206) with slight modification in order to increase the yield. The cytoplasmic
      isozyme is purified by heat treatment followed by ion exchange cellulose
      chromatography and gel chromatography. The enzyme is pure in the ultracentrifuge
      and in polyacrylamide gel electrophoresis; it shows only one anionic band and no
      subforms. It has a molecular weight of 93,000 +/- 2000 and is composed of two
      subunits of 46,000 M.W. The enzyme has a specific activity of 49 micronmoles of
      oxalacetate x min-1 x mg-1. It contains 5 SH groups per subunit; three are
      directly titratable with p-mercuribenzoate and the other two only after addition
      of 0.2% SDS; there is no evidence of S-S groups. Km values for aspartate,
      glutamate, alpha-ketoglutarate and oxalacetate are in the order 1.25, 3.2, 0.06
      and 0.41 mM in the cytoplasmic isozyme and 0.7, 5.0, 1.25 and 0.12 mM in the
      mitochondrial one.

PMID- 1037467
TI  - L-Asparaginase: effect on 7S gamma globulin extents and germinal centers in
      spleen and lymph-nodes.
AB  - Administration of L-asparaginase may cause remission in a high percentage of
      acute lymphocytic leukemias and lymphomas, either in experimental animals or in
      human beings. This enzyme is able to depress immune reactions like lymphocyte
      blastogenesis and delayed hypersensitivity, and to impair gamma-globulin
      synthesis. L-asparaginase also has antigenic properties, and may cause the
      formation of anti-L-asparaginase antibodies. This study reports observations on
      the effect of L-asparginase on the 7S gamma-globulin levels and on the behaviour
      of the germinal centers in spleen and lymph nodes. It has been found that after
      administration of low or intermediate doses of L-asparginase, a decrease in the
      size of the follicular marginal zones occurred. This was accompanied by an
      enlargement of the germinal centers. Furthermore the spleen weight decreased and
      the concentration of 7S gamma-globulin diminished slightly. In animals given high
      doses of L-asparaginase, germinal centers were enlarged even more but marginal
      zones appeared repopulated although not to the degree of the controls. The spleen
      weight of these enzyme-injected animals reached almost the normal values, while a
      statistically significant decrease of 7S gamma-globulin concentrations was found.

PMID- 1037468
TI  - [Retinol and lipid peroxidation].
AB  - The addition of retinol "in vitro" to erythrocyte ghosts and to subcellular
      fractions of normal rat liver, kidney and spleen homogenates, strongly decreases
      their lipid peroxide production. This retinol-effect is dose-dependent and can be
      observed also at physiological doses. The antilipoperoxidative effect of retinol
      has also been demonstrated "in vivo", in the nuclear and mitochondrial fractions
      of liver homogenates and in the nuclear fraction of spleen homogenates. A
      contrasting effect (prolipoperoxidative) of retinol has been observed in
      mitochondrial fraction of kidney and spleen homogenates and in the microsomial
      fraction of spleen homogenates. These results are discussed and related to
      tocopherol metabolism in A-hypervitaminotic rats and to the well-known antagonism
      between retinol and cholecalcipherol, whose prolipoperoxidative action "in vivo"
      is recorded.

PMID- 1037469
TI  - [Regulation processes in biological systems. I. General principles and enzymatic
      control mechanisms].
AB  - A property, characteristic of all living organisms, is the ability to adapt their
      metabolism to changes of environment. Such an adaptation, i.e. a regulation of
      metabolism, is made possible not only by nervous and hormonal mechanisms, but it
      is also caused by the cooperation of enzymes and enzyme systems localized in
      different cell areas and may called "enzymic regulations". Enzymes are functional
      units of complex chemical systems. Although present knowledge in this area is
      primitive, it is already apparent that the properties of regulatory enzymes are
      very precisely tailored to the needs of the cells  in which they occur. The
      kinetic behaviour of an enzyme can be rationally interpreted only in terms of
      metabolic function and the structural features of an enzyme molecule are only the
      means by which this behaviour is attained. Each enzyme has evolved in the context
      of a metabolizing cell and the progress in understanding the kinetic and
      structural properties of enzymes will be aided by progress toward understanding
      the interactions in which that enzyme participates in the living cell. It is
      certain that we have only just begun to comprehend the ways in which the enzymes
      interact to produce a stable, yet flexible and responsive metabolic unit.

PMID- 1037470
TI  - [Health of the Spaniards. Current situation and conditioning factors].

PMID- 1037471
TI  - [The mother, alcohol, and offspring].

PMID- 1037472
TI  - [Current status of the surgical treatment of duodenal ulcer].

PMID- 1037473
TI  - [Giant sacro-coccigeal chordoma and function of the anal and bladder sphinctern].

PMID- 1037474
TI  - [On the evaluation of the deficiencies, handicaps and corporal prejudices in the
      processes thoracic diseases].

PMID- 1037475
TI  - [Stages of the development of the embryos of snakes by the time of oviposition].
AB  - Embryos of 6 species of snakes--Ptyas mucosus (L.), Elaphe dione (Pall.),
      Psammophis lineolatum (Brandt), Natrix tesselata (Laur), Naja oxiana (EICHW.),
      Vipera lebetina turanica (Cernov) and V. l. obtusa--at the stage of egg laying
      are described morphologically. Different species of snakes are shown to lay the
      eggs containing embryos of different degrees of maturation. This series of
      transitions at the embryonic age (up to the time of egg viviparity) is connected
      with ecological peculiarities of different species.

PMID- 1037476
TI  - Bromocriptine in refractory post partum lactation.

PMID- 1037477
TI  - Vagrant women and venereal disease.

PMID- 1037478
TI  - Intrathecal administration of CDP-choline into the lower lumbar subarachnoid
      space in two patients with post-traumatic akinetic mutism.

PMID- 1037479
TI  - Experiences in a paediatric gastroenterology clinic.

PMID- 1037480
TI  - The  contribution of computerized axial tomography to ophthalmology.

PMID- 1037481
TI  - Allergy and infant feeding.

PMID- 1037482
TI  - Absolute configuration and biological activity of viminol stereoisomers.

PMID- 1037483
TI  - Clinical studies with bromocriptine in idiopathic parkinsonism.

PMID- 1037484
TI  - Bringing comprehensive health care to a rural setting: islands near Charleston
      provide setting for first Urban Health feature on rural health activity.

PMID- 1037485
TI  - Training is not enough!

PMID- 1037486
TI  - OD and the role of the external consultant.

PMID- 1037487
TI  - ASHET: organization development.

PMID- 1037488
TI  - OD problem diagnosis: a model.

PMID- 1037489
TI  - Contracting for OD: toward a consultant-client team.

PMID- 1037490
TI  - Hospital alcoholism programs reach the community and business.

PMID- 1037491
TI  - ASHET: educators within institutions.

PMID- 1037492
TI  - Assert yourself for effectiveness.

PMID- 1037494
TI  - Proposed HIP rate increase meets with opposition.

PMID- 1037493
TI  - Get professional recognition for inhouse CE courses.

PMID- 1037495
TI  - Sex discrimination, HMOs and ERISA reviewed at AMA personnel conference.

PMID- 1037496
TI  - U.S. District Court orders payment of maternity benefits to unwed mothers under
      Title VII.

PMID- 1037497
TI  - Re-survey "Fortune 500"; interest in HMOs triples.

PMID- 1037499
TI  - Bill would limit Sec. 105(d) sick pay exclusion.

PMID- 1037498
TI  - States grudgingly grant Blues rate increases.

PMID- 1037500
TI  - Prescription drug plans popular with everyone--including providers.

PMID- 1037501
TI  - Propose commission to oversee health system.

PMID- 1037503
TI  - Federal employees' suit seeks to cut premium boost in half.

PMID- 1037502
TI  - Group accident & health in 1975 by lines.

PMID- 1037504
TI  - Blue Shield unnecessary surgery program to examine cost savings from data.

PMID- 1037505
TI  - Findings disputed on reports of medical incompetencies.

PMID- 1037506
TI  - Industry's alcoholism programs reducing absenteeism, costs.

PMID- 1037507
TI  - Radiologists disclose withdrawal of College's relative value scale.

PMID- 1037508
TI  - Maryland hospitals support government efforts to reduce Blue Cross 'discounting'
      practices.

PMID- 1037509
TI  - N. Y. Blues experiment with control of elective surgery.

PMID- 1037510
TI  - Wisconsin nursing home ombudsman program shows scoreboard on complaints.

PMID- 1037511
TI  - Elective surgery increased after implementation of Canadian medical insurance.

PMID- 1037512
TI  - Urges writing cost-sharing into NHI to offset control employer is sure to lose.

PMID- 1037513
TI  - More employees covered for disability in '74, but claims experience off: N. Y.
      study.

PMID- 1037514
TI  - Kansas lops $2,600,000 from Blues' rate hikes.

PMID- 1037516
TI  - N.J.'s Sheeran makes specific cost control suggestions, including merger, to BC
      BS plans.

PMID- 1037515
TI  - Anti-selection can play an important role in HMO coverage, Rochester experience
      demonstrates.

PMID- 1037517
TI  - Reluctance evident in slow growth of same-day surgery.

PMID- 1037518
TI  - FTC launches effort to knock down anti-ad rules for doctors, others.

PMID- 1037519
TI  - Umpire rules phone treatments are covered by health fund.

PMID- 1037520
TI  - Use of fee-for-service, indemnity plans exceeds use of HMO, studies show.

PMID- 1037521
TI  - TDA offers alternative cooperation to carriers.

PMID- 1037522
TI  - General Mills cuts inpatient days with HMO; 49% of Minneapolis-area employees
      choose option.

PMID- 1037523
TI  - Dual choice option: opinions of labor presented by Seidman at GHAA meeting.

PMID- 1037525
TI  - Hospital admissions down; but emergency visits, costs increase.

PMID- 1037524
TI  - HEW integrates health figures with other trends.

PMID- 1037526
TI  - Caesarean deliveries on the rise.

PMID- 1037527
TI  - Speakers urge acceptance of HMOs by employers.

PMID- 1037528
TI  - [Trans-membrane difference of the vascular wall potentials and electrolyte
      content under the effect of nicotine and pentamine].
AB  - In experiments with anesthetized cats the effect of nicotine and pentamine with
      their intravenous administration into the organism on the transmembraneous
      difference on the carotid artery potentials and electrolytes exchange in the
      vascular wall was analyzed. Nicotine (60 and 120 gamma/kg) was found to increase
      the difference of potentials in the vascular wall of the carotid artery and
      pentamine (1 and 10 mg/kg)--to reduce it. Nicotine raised the level of potassium
      and downgraded the sodium concentration in the vascular wall, while changes in
      the proportion of calcium and magnesium ions proved to be insignificant and were
      demonstrable only in individual vessels. Pentamine increased the potassium and
      sodium content in the wall of blood vessels, excercising but little effect on the
      level of calcium and magnesium ions. A relation between changes in the
      transmembraneous difference of potentials and variations of the ionic composition
      in the vascular wall, mostly of potassium and sodium ions, is suggested.

PMID- 1037529
TI  - Organizing human services in Florida. A study of the public policy process.

PMID- 1037531
TI  - [Surface activity of the extracts of the lungs and other organs].
AB  - Monomolecular surface films on the border-line of the "liquid-air" phases were
      observed to be formed in the water-saline extracts of the lungs and of the other
      organs. The surface films were compressed and extended on Wilhelmy's balance; the
      isotherm surface tension (ST)-square typical of the solutions of the surface
      active materials (SAM) were recorded. Analogous curves with the minimum ST below
      12 din/cm were recorded in testing the SAM monolayers placed on the liquid lining
      of the volatile solvent. Pulmonary surfactants differed from the SAM of other
      organs by the highest capacity to lower the ST in compression of the monolayer.

PMID- 1037532
TI  - [Effects of ceruletide in the treatment of postoperative paralytic ileus].
AB  - After a short analysis of the pathogenetic causes which can lead to paralytic
      ileus and the drugs at present available for treatment of this serious morbid
      form, the paper reports results obtained with Ceruletide, a decapeptide which has
      proved active on intestinal peristalsis in experimental and clinical trials. The
      results of this study, carried out on 20 patients subjected to surgical operation
      on the abdomen, treated with Ceruletide by intramuscular route 24-48 hours after
      the operation, showed that this drug is capable of leading to a quick recovery of
      intestinal motor activity without causing the patient unpleasant effects for the
      patient. The practical utility of Ceruletide is evident since by leading to
      earlier canalisation of the intestine it also allows the venous hydro-electric
      delivery to be reduced, nasogastric aspiration to be eliminated early and hence
      the postoperative course to be made more acceptable to the patient.

PMID- 1037533
TI  - Studies on the new cell line TT-I: viral susceptibility and chromosomal changes
      related to mycoplasma contamination.
AB  - For understanding some biological properties of TT-1 cell line established in our
      laboratory in 1962, its viral susceptibility and the changes in chromosomes
      related to mycoplasma contamination were studied. TT-1 cells were susceptible to
      the infection of picorna (Polio type 1, Coxsackie B1 and Echo type 2), measles,
      Newcastle disease, herpes simplex (type 1), adeno (type 12) and vaccinia viruses.
      Contamination of TT-1 cells with Mycoplasma hominis was treated successfully with
      bottromycin A2 (50 microgram/ml). The chromosomes of the cells ranged from 52 to
      55 in number and two additional minute chromosomes were found in the cells
      contaminated with the mycoplasma. However, after treatment with bottromycin,
      these two minute chromosomes disappeared.

PMID- 1037534
TI  - Prevalence of cytoplasmic antibodies in systemic lupus erythematosus.
AB  - Prevalence of cytoplasmic antibodies--smooth muscle antibodies (SMA), gastric
      parietal cell antibodies (GPA), and mitochondrial antibodies (MTA)--was evaluated
      in 148 normal persons and 168 patients by indirect immunofluorescent method.
      Their prevalence in normal persons was 0%, 2% and 0% for SMA, GPA and MTA
      respectively, while SMA and MTA were positive in 5.7% and 8.6% of the 35 systemic
      lupus erythematosus (SLE) patients respectively. The difference in the prevalence
      of SMA and MTA between these two groups was statistically significant. The higher
      prevalence of these antibodies and the occurrence of various kinds of antibodies
      in SLE patients support the thesis that SLE is an autoimmune phenomenon.

PMID- 1037535
TI  - Standardization of antimicrobial disc susceptibility test for anaerobic bacteria.
AB  - Both agar diluiton and agar diffusion tests with 8 clinically useful or
      potentially useful antimicrobial agents were performed with 74 strains of
      Bacteroides fragilis. Correlation of results obtained by the two methods and
      applicability of the single disc test to the measurement of antimicrobial
      susceptibility of anaerobes were analyzed. Prediction of susceptibility,
      intermediate susceptibility, and resistance of anaerobic bacteria to
      antimicrobial agents, based on the measurement of inhibition zone diameter,
      appeared to be satisfactory generally.

PMID- 1037536
TI  - In vitro phagocytosis of Trypanosoma musculi by mouse macrophage.

PMID- 1037537
TI  - Malic dehydrogenase patterns in different strains of Schistosoma japonicum and
      subspecies of Oncomelania hupensis.
AB  - Malic dehydrogenase (MDH) of the Formosan Philippine and Indonesian Strains of
      Schistosoma japonicum and 3 subspecies of snails, Oncomelania hupensis formosana,
      O. h. quadrasi, and O. h. lindoensis were identified by disc electrophoresis with
      10.5% acrylamide gel columns using tris-malic buffer. Male worm extracts of S.
      japonicum demonstrated 3, 2, and 2 clear MDH patterns and female worm extracts
      showed patterns of 2, 1 and 1 for the Formosan, Philippine and Indonesian strains
      of the parasite, respectively. MDH patterns were the same for all 3 subspecies of
      snails; one major and one minor band being found in all.

PMID- 1037538
TI  - Angiostrongylus cantonensis in rats on Makung, Pescadores Islands (Peng Hu).

PMID- 1037539
TI  - Federal Trade Commission continues antitrust campaign in move against Blue
      Shield.

PMID- 1037540
TI  - Supreme Court dismisses Wetzel discrimination-in-maternity-benefits case.

PMID- 1037541
TI  - Auto industry health care cost issue boils over; cos. want to "share" costs, UAW
      threatens BC-BS.

PMID- 1037542
TI  - GM executive outlines health care cost controls.

PMID- 1037543
TI  - Rocky Mountain HMO one of two IPA's qualified under Act.

PMID- 1037544
TI  - Administration backs HMO amendments, but differs with pending bills on some
      points.

PMID- 1037545
TI  - Prospective reimbursement; a step to cut hospital costs.

PMID- 1037546
TI  - Physician maldistribution means poor care for 1 in 5.

PMID- 1037547
TI  - Blues in several states use second opinions.

PMID- 1037548
TI  - Drug firms agree to pay carriers $12.5 million.

PMID- 1037549
TI  - Sweden's broad statutory health, sick leave benefits.

PMID- 1037550
TI  - "Maximum allowable cost" effective date delayed.

PMID- 1037551
TI  - 500,000 railroad employees get dental coverage.

PMID- 1037552
TI  - Private health plans cater to "snob appeal".

PMID- 1037553
TI  - Minnesota sets minimum standards for health insurance plans; mandates HMO dual
      choice clause.

PMID- 1037554
TI  - Blue Cross influences health care delivery.

PMID- 1037555
TI  - "Dental is different" says Penn. Blue Shield VP.

PMID- 1037557
TI  - New qualified HMO in Delaware Valley.

PMID- 1037556
TI  - Has U.S. health care system reached an impasse? Improvement to be minimal, cost
      great, prof. says.

PMID- 1037558
TI  - Book says health system not likely to change.

PMID- 1037559
TI  - Alcoa manager testifies about company program to control health care costs.

PMID- 1037560
TI  - Natl. Health Planning Act called last attempt at local input.

PMID- 1037561
TI  - Lack of privacy hit at hearing; "open" medical data cited.

PMID- 1037562
TI  - High court postpones sex-discrimination-in-maternity-benefits case.

PMID- 1037563
TI  - Supreme Court okays prescription drug advertising; FTC to investigate possible
      AMA restraint of trade.

PMID- 1037565
TI  - Amendments will help HMOs compete in marketplace; 25 employees in service area
      needed for activation.

PMID- 1037564
TI  - IPA plan in Rochester, N.Y. terminates; subscribers offered three coverage
      options.

PMID- 1037566
TI  - South African government sets minimum standards for private health coverage.

PMID- 1037567
TI  - Employer should evaluate dental carrier; chart outlines five major plans.

PMID- 1037568
TI  - Multiphasic screening does not always mean better health care, changed behavior.

PMID- 1037569
TI  - Evaluating premiums for voluntary AD&D coverage.

PMID- 1037570
TI  - New York HSA cites excess open-heart surgery units.

PMID- 1037571
TI  - Views: enrollment in a health maintenance organization option.

PMID- 1037572
TI  - NHI not likely to pass Congress during 1976.

PMID- 1037573
TI  - Subchapter S prof. corp. loses pension deduction.

PMID- 1037574
TI  - GAO drug-price audit fought; firms say costs unknowable.

PMID- 1037575
TI  - Hospital administrators discuss cost control.

PMID- 1037576
TI  - HMO conference finds activated employers cautiously moving to implement choice.

PMID- 1037577
TI  - HEW doesn't expect strict compliance with HMO law.

PMID- 1037578
TI  - Insurers becoming more involved in HMOs, HIAA tells Kennedy.

PMID- 1037579
TI  - Western Clinic of Tacoma quits prepaid group practice.

PMID- 1037581
TI  - Blue Cross-Blue Shield plans attacked thrice.

PMID- 1037580
TI  - New national health plan takes effect in Australia.

PMID- 1037582
TI  - New York research says second opinion programs permanently defer surgery.

PMID- 1037583
TI  - Many factors must be considered when examining the rising cost of hospital care.

PMID- 1037584
TI  - Views: activation by HMOs.

PMID- 1037585
TI  - How Michigan Blues contain health care costs.

PMID- 1037586
TI  - Although employer is administrator for plan, insurer is liable.

PMID- 1037587
TI  - Physicians have role to play in hospital cost control.

PMID- 1037588
TI  - Tax Reform Act of 1976 changes sick pay, allows "joint" IRAs boosts ESOPs and
      prepaid legal.

PMID- 1037589
TI  - FTC prohibits Spokane HMO boycott.

PMID- 1037590
TI  - GAO outlines HMO roadblocks in report to Congress.

PMID- 1037591
TI  - How Sears, Roebuck is complying with HMO Act.

PMID- 1037592
TI  - New Chicago HMO will experience-rate inpatient costs.

PMID- 1037593
TI  - HEW acts on home care, SNFs.

PMID- 1037594
TI  - Surgicenters planned in Washington, D.C., area.

PMID- 1037596
TI  - Two states start prospective role review.

PMID- 1037595
TI  - Pre-admission testing saves money, BC-BS says.

PMID- 1037597
TI  - How R.J. Reynolds started successful HMO.

PMID- 1037598
TI  - NAEHMO develops HMO checklist.

PMID- 1037599
TI  - Four essential ingredients of a well-designed dental program outlined by actuary.

PMID- 1037600
TI  - Computer eases administration of dental claims.

PMID- 1037601
TI  - Normal pregnancies to be covered under Cal. UCD.

PMID- 1037602
TI  - CEB speakers urge employers to become involved in hospital cost control programs.

PMID- 1037603
TI  - [Physiopathology of postoperative respiratory insufficiency].

PMID- 1037604
TI  - [Radiotherapy of mediastinal tumors--analysis of irradiated patients at the
      Radiological Institute in Belgrade in the 10 year period from 1960 to 1971].

PMID- 1037605
TI  - [Whey as a substrate for obtaining an edible yeast].
AB  - Using a fermentative process of whey through Kluyveromyces fragilys, Jorgensen,
      the Author prepared two edible products: Biomass I (yeast) and Biomass II (yeast
      plus protein of whey). Biomass I offered 53% of protein, and the yield was 22,3
      g/1 whey. Biomass II, 62% of protein and yield of 27,7 g/1 whey. The test of food
      efficiency for Biomass II was similar to that presented by casein; the protein
      eficiency ratio at the level of 5% was the same, both for Biomass I and II. More
      research is needed specially to determine the economical convenience of the
      process.

PMID- 1037606
TI  - [Studies on the excretion-dynamics of surface active materials on an animal model
      of fibrosing alveolitis].

PMID- 1037607
TI  - Surface activity of pulmonary alveolar lipids from dogs subjected to hemorrhagic
      shock.

PMID- 1037608
TI  - [Use of nitrates in cheese-making].
AB  - In the technology of semi-hard cheeses, nitrate is added to prevent thelate
      blowing defect due to the growth of Clostridia. In normal technological
      conditions no risks must be encountered by the consumer. But if whey is re-used
      for feeding the amount of nitrate and nitrite in the whey must be controlled.

PMID- 1037609
TI  - [Special examinations, especially nuclear medicine methods, for the determination
      of an endocrine opthalmopathy].

PMID- 1037610
TI  - [Modification of the defecation frequency through variously prepared milk.
      Clinical study of subjects with different milk tolerance].

PMID- 1037611
TI  - Model ecosystem evaluation of the environmental impacts of the veterinary drugs
      phenothiazine, sulfamethazine, clopidol, and diethylstilbestrol.
AB  - Four veterinary drugs of dissimilar chemical structures were evaluated for
      environmental stability and penchant for bioaccumulation. The techniques used
      were (1) a model aquatic ecosystem (3 days) and (2) a model feedlot ecosystem (33
      days) in which the drugs were introduced via the excreta of chicks or mice. The
      model feedlot ecosystem was supported by metabolism cage studies to determine the
      amount and the form of the drug excreted by the chicks or mice. Considerable
      quantities of all the drugs were excreted intact or as environmentally short
      lived conjugates. Diethylstilbestrol (DES) and Clopidol were the most persistent
      molecules, but only DES bioaccumulated to any appreciable degree. Phenothiazine
      was very biodegradable; sulfamethazine was relatively biodegradable and only
      accumulated in the organisms to very low levels. Data from the aquatic model
      ecosystem demonstrated a good correlation between the partition coefficients of
      the drugs and their accumulation in the fish.

PMID- 1037612
TI  - [Acute myocardial infarct in Africans in Djibouti. Study of 62 cases].

PMID- 1037613
TI  - [A small case for the epidemiologic surveillance of smallpox, cholera and yellow
      fever. Note of presentation].

PMID- 1037614
TI  - [Evaluation of 25 years of antileprosy chemotherapy in French Polynesia.
      Influence of age on the onset of the disease].
AB  - In French Polynesia the cases of leprosy are individually severe, like in Asia,
      but the endemy always stood under a relatively low level. A strong campaign of
      chemiotherapy has been conducted for 25 years. Unfortunatly the actions of
      systematic detection of new cases are not sufficient and the sanitary education
      is almost non existent. The territory is actualy reached by deep demographic and
      social upsettings and chemiotherapy used alone is not enough efficient to obtain
      a definitive decrease of the endemy or even to avoid, for a long time, a new
      increase. However a significant decrease of the age of advent of the decrease
      must be credited to the action of chemiotherapy.

PMID- 1037615
TI  - [Impact of a profound change in the structure of a society on the evolution of an
      endemic disease: leprosy in French Polynesia].
AB  - In French Polynesia the cases of leprosy are individually severe but the endemy
      itself always stood in low limits. The intensive use of modern treatments since
      1950 have been making the eredication reasonably possible in the future. However
      the brutal demographic increase, the deep upsetting of the society and the
      important migrations made propitious conditions in the urbanized area for the
      advent of a new centre of infection. The result seems to be an increase of
      leprosy in the territory.

PMID- 1037616
TI  - [Experimental "per os" transmission of Entomophthora coronata to the mouse].
AB  - Mycelial fragments of E. coronata have been observed in the pus of abscesses of
      the neck and the shoulder of mice inoculated per os, far from the point of
      inoculation. However, the subcultures were negative; a positive subculture was
      obtained in only one instance from a lung taken off ten days after the
      inoculation by the fungus.

PMID- 1037617
TI  - [Eosinophilia and lymphatic filariasis in French Polynesia].
AB  - An important hypereosinophilia is usually regarded as an interesting argument of
      presumption in lymphatic filariasis. This present report concerns 278 Polynesians
      people infected with Wuchereria bancrofti pacifica. Six kinds of patients were
      analysed: carriers of microfilarias, patients with elephantiasis, with
      lymphangitis attacks, new infections, carriers of microfilariasis recently
      treated with Diethylcarbamazine and, at least, 100 fellows without filariasis.
      The results which were observed differ, in some aspects, from the usually
      admitted ideas.

PMID- 1037618
TI  - [Hypersensitivity in ciguatera ichthyosarcotoxism: an experimental model].

PMID- 1037619
TI  - [A case of human hepatic linguatulosis].

PMID- 1037620
TI  - [Changes in platelet adhesiveness in hemorrhagic dengue].

PMID- 1037621
TI  - [2d leishmaniasis attack in a patient in French Guiana having presented the 1st
      leishmaniasis 4 years previously].

PMID- 1037622
TI  - [Imported tropical parasitosis in Rumania].
AB  - The frequency of intestinal parasitoses among subjects coming from warm countries
      is high and its range is similar to that found by other parasitologists in Europe
      as well as by those who made investigations in groups of individuals in various
      warm countries. Bearing in mind the pathogenous role--even limited--of certain
      parasites, their systematic detection and the treatment of every individual
      infested with parasites appears necessary. The hereby investigations point out
      the importance of a complex coproparasitologic examination and the high
      efficiency of some special diagnosis methods. Every laboratory must perform in
      rarallel several ovoscopic and larvoscopic methods of investigation in view of an
      accurate parasitologic diagnosis or for a prophylactic control of subjects coming
      from warm countries. The high frequency of ankylostomiasis raises peculiar
      problems related to its systematic detection and its compulsory treatment up to
      the parasitologic sterilization, bearing in mind the past evolution in Rumania of
      an underground focus, which does not exist any more, having been entirely
      eradicated.

PMID- 1037623
TI  - [Deviation of the life cycle of Dipetalonema viteae (Filarioidea)].
AB  - Dipetalonema viteae is a filarial that can evoluate among hosts zoologically
      broadly apart (Ixodides and Argasides), but always gathered from meriones
      burrows. Its evolution is, on the contrary, blocked among most of the other
      ticks, particularly among Ornithodoros erraticus morphologically very similar to
      the normal vector. Our work concerns the experimental deviation of the cycle of
      Dipetalonema viteae, with its possible adaptability in the bosom of an
      intermediate of fowl tropism and a permanent host, different from a gnawing.

PMID- 1037624
TI  - [Human trichinosis. A recent epidemic in Vientiane (Laos) (apropos of 32 cases)].
AB  - Fifty patients were hospitalised at Vientiane during May and June 1975. Infection
      was caused by consumption of pork meat (som-mou, lap mou and lap leuat). After an
      incubation period of 8 to 11 days intermittent diarrhoea followed by constant
      fever and orbital oedema occurred. Several days later diffuse myalgias occurred.
      Three patients presented neurological symptoms: left hemiplegia flexible
      paraplegia and limb paresis; these symptoms regressed spontaneously. 87% of the
      clinically suspected cases had specific serum antibodies (IFI, ID, IE).
      Hyperleucocytosis and hypereosinophilia were a constant factor. Anti-AH
      antibodies were detected by the Widal test. The histopathology characteristic of
      myositis was seen in the 12 muscle biopsies. Also observed was the precystic
      state of the larvae which is in agreement with the early timing of the samples
      which were obtained during the 3rd and 4rd week of infection.

PMID- 1037625
TI  - [10th case of lobomycosis observed in French Guiana].
AB  - Lobomycosis a disease specific to the South-American continent; it is rare but
      not exceptional, since 11 cases have already been observed in French Guyana. A
      propos of the 10th case, the authors recall the circumstances of the discovery
      and the basic elements of the microscopical diagnosis. The actual progress in the
      in vivo culture techniques should allow a better knowledge of the pathogen agent
      in the future.

PMID- 1037626
TI  - Regeneration-promoting properties of tribenoside in Amblystoma mexicanum.
AB  - Tribenoside in a dose of 100 mg/kg i.p. significantly accelerates the
      regeneration of puncture wounds in the caudal membrane of Amblystoma mexicanum. A
      dose of 200 mg/kg exerts a less-pronounced vulnerary effect and is occasionally
      toxic. Tribenoside also stimulates regeneration in this species when added to
      bath fluid in a concentration of 1:400,000 (exposure for 6 h daily). A
      concentration of 1:200,000 is less effective and has a slightly irritant effect
      on the tissue. 14 days after operation, the rate of mitosis in the regenerative
      blastema is distinctly greater than that demonstrable in the normal integument of
      the axolotl. The number of cell divisions in the regenerating tissue is not
      significantly altered by tribenoside in a concentration of 1:400,000. The
      possible involvement of other mechanisms in the stimulated regeneration observed
      after treatment with tribenoside is discussed.

PMID- 1037627
TI  - A case of cutaneous bovine leucosis in Hungary.

PMID- 1037628
TI  - "The orbit" (a review).

PMID- 1037629
TI  - [Vitamin B1 resorption. IV. Level of sulfhydryl groups in intestinal mucosa
      resorption of 35S-thiamine].
AB  - Studies have been carried on with the aim of investigating the effect of SH
      groups on the absorption of 35S-thiamine in chicken's duodenum. The trial has
      been performed in chickens aged 56 days; as SH-groups releasing agents L-cysteine
      and SH-glutathion have been utilized; urea has been used in order to release SH
      groups from protein molecules. The absorption of 35S-thiamine in duodenum is
      significantly increased in the presence of L-cysteine, SH-glutathion and urea.
      35S-thiamine appears to be stored in the intestinal mucosa more conspicuously in
      the presence of urea. Concomitanly with the high levels of SH-groups in the
      duodenal mucosa, also the thiamine absorption results to be increased (P less
      than 0.001).

PMID- 1037630
TI  - [Vitamin B1 resorption. V. The effect of an extract of male sex glands and of 4,4
      dioxydiphenylhexane on thiamine resorption].
AB  - A research was made to investigate how a male sexual gland extract and 4,4
      dioxydiphenylhexane affect the absorption of thiamine in chicken's duodenum. A
      reduction was observed of thiamine conveyed to the intestine and of thiamine
      diphosphate concentration blood levels in duodenal artery and vein, as well as in
      liver. At the same time also a decrease of SH groups in duodenal mucosa was
      observed. The absorption of 35S-thiamine is increased after addition of SH
      glutathione and L-cysteine, as free SH-groups releasing agents.

PMID- 1037631
TI  - Problems and proposals on the study of tryptophan metabolism.

PMID- 1037632
TI  - [Distribution and depletion with time of retinol-C14 in different tissues and
      organs of albino rats].
AB  - Albino male rats of Wistar strain, weighing about 350 g., were administered
      orally a single dose of 2,50 mu C of retinol-C14 after a fast of 24 h. At
      intervals of 3 h and of 3, 6, 12, 18 and 24 days rats were killed; livers,
      kidneys, blood, white fat tissue and brown fat tissue were removed. Samples were
      dried and radioactivity was measured. From the results, expressed in mu C/g of
      dry tissue, it is clear that vitamin A is taken up by all tissues. After 3 days
      it decreases in all tissues, between the 3rd and 18th day, its rate is constant
      and the depletion is complete within 24 days.

PMID- 1037633
TI  - [Variations of retinol-C14 incorporation in rats of different ages fed a vitamin
      A-free diet].
AB  - Two groups of Wistar strain male albino rats of different age were treated with a
      large dose (300 I.U.) of vitamin A-acetate, after 24 h fasting. Each rat was then
      administered orally a single dose of 1,25mu C retinol-C14 to determine the rate
      of incorporation into different tissues. At intervals of 3 h and of 3, 6, 12 days
      the rats were killed; liver, kidney, blood, white fat tissue, brown fat tissue
      were taken and dried. Radioactivity was measured. The results show that in all
      tissue the mean percentage of incorporation, expressed in muC/g dry tissue, is
      generally higher in young than in adult rats.

PMID- 1037634
TI  - [Notes on vitaminology for practitioners and suggestions for a new terminology
      for avitaminoses].

PMID- 1037635
TI  - [Psychological barriers and inhibition in epidemiological interviews].

PMID- 1037636
TI  - Leukocyte migration inhibition in vitro in untreated and methimazole-treated
      patients with Graves disease.
AB  - The leukocyte migration tests has been applied to investigate immune-reactivity
      of 43 untreated and methimazole-treated patients against thyroid crude antigen. A
      significant migration inhibition was observed in 21 untreated patients, while in
      22 methimazole-treated patients the migration test was negative independently of
      T3 suppressibility. Migration inhibition against thyroid antigen and purified
      protein derivative (PPD) was reduced or abolished after preincubation with
      methimazole of leukocytes of untreated patients. It seems that methimazole
      treatment influences not only thyroid iodine metabolism, but by means of a direct
      effect on lymphocytes it also decreases the pathological stimulation.

PMID- 1037637
TI  - The effect of the antibilharzial compound (Bilharcid) on Schistosoma mansoni in
      vitro and in vivo.
AB  - The effect of Piperazine diantimonyl tartrate (Bilharcid) as compared with that
      of tartar emetic on Schistosoma mansoni has been studied. In vitro experiments on
      living worms in tyrode/serum cultures have proved that Bilharcid 5-10 gamma/ml
      has the same antibilharzial activity as tartar emetic in 5-10 gamma/ml. In vivo
      experiments on Schistosoma mansoni infected mice have proved also that Bilharcid
      has more or less the same effect as that of tartar emetic. In this study, the
      worm burden load and the oogram techniques were used as the criteria for
      antibilharzial assessment.

PMID- 1037638
TI  - [Cervical metastases from occult carcinoma].

PMID- 1037639
TI  - [Ectopic thyroid at the base of the tongue (case reports)].

PMID- 1037640
TI  - [Evaluation of lacrimal secretion in subjects treated with vidianectomy or
      sphenopalatine gangliectomy].

PMID- 1037641
TI  - [Hemilaryngectomy in partial surgery of cancer of the larynx].

PMID- 1037642
TI  - [Auditory evoked potentials in the aged subject. (Report to the XXVII Congresso
      Nazionale A.O.O.I. in Vibo Valentia in 1975)].

PMID- 1037643
TI  - [Audiological studies of infants under 1 year of age].

PMID- 1037644
TI  - [Tests and considerations of suspension microlaryngoscopy without intubation].

PMID- 1037645
TI  - [Monitoring of patients undergoing antineoplastic treatment and/or surgery].

PMID- 1037646
TI  - [Subvigil anesthesia in adenotonsillectomy in children].

PMID- 1037647
TI  - [Subvigil anesthesia in rhinoseptoplastic operations].

PMID- 1037648
TI  - [Systemic hyperfibrinolysis and adenotonsillectomy].

PMID- 1037649
TI  - The effect of D-penicillamine on the albumin-bilirubin complex.

PMID- 1037650
TI  - [Electrodiagnostic studies in facial nerve paralysis].

PMID- 1037651
TI  - [Choice of technic in the surgical treatment of cholesteatoma in childhood].

PMID- 1037652
TI  - [Peripheral and central chemoreceptors and ventilatory regulation mechanisms in
      hypoxia states].

PMID- 1037653
TI  - [Effect of single semicircular canals on medial geniculate body units].

PMID- 1037654
TI  - [Papillary cystadenolymphoma of the parotid gland. Report of a case of bilateral
      papillary cystadenolymphomas of simultaneous appearance].

PMID- 1037655
TI  - [Our experience with the surgical treatment of chronic sero-mucous otitis media
      in children].

PMID- 1037656
TI  - [Alterations of acid-base equilibrium of respiratory origin].

PMID- 1037657
TI  - [Anatomo-clinical aspects of a case of esthesioneuroepithelioma].

PMID- 1037658
TI  - [Removal of the clavicle as a complementary surgical procedure in radical neck
      dissection].

PMID- 1037659
TI  - [Possibilities of the use of a muco-fluidifying compound (iodopropylideneglycerol
      of IPG) in aerosol therapy of the tracheobronchial hypersecretion syndrome in
      largyngectomized patients].

PMID- 1037660
TI  - [A case of probable meteoropathological, late recurrent tonsillar hemorrhage].

PMID- 1037661
TI  - [Possibilities of the use in the tracheo-bronchial hypersecretion syndrome of a
      muco-fluidifying compound].

PMID- 1037662
TI  - In vitro microagglutination of human spermatozoa by ethinyl estradiol: a brief
      communication.

PMID- 1037663
TI  - [Post-abortion transitory and stable hypoovaria].

PMID- 1037664
TI  - Rejoinder: toward optimal arousal and away from original din.

PMID- 1037665
TI  - The aetiological evaluation of acute microbial conjunctivitis in Greece.
      Epidemiological study.

PMID- 1037666
TI  - Surgical management of nasal obstruction.

PMID- 1037667
TI  - The allograft incus: an otologic necessity.

PMID- 1037668
TI  - Stromal herpes simplex keratitis.

PMID- 1037669
TI  - The health care consumer: compliant captive?

PMID- 1037670
TI  - Of half gods and mortals: Aesculapian authority.

PMID- 1037671
TI  - Sex discrimination in health care.

PMID- 1037672
TI  - Some crucial terms in nursing--a second opinion.

PMID- 1037673
TI  - Premature reassurance: a distancing maneuver.

PMID- 1037675
TI  - A do-it-yourself restraint that works!

PMID- 1037674
TI  - Mutual Hostility--that was the risk with Mark. He wasn't exactly a demanding
      patient. He had but one demand: "Leave me alone".

PMID- 1037676
TI  - How well do you understand cirrhosis?

PMID- 1037677
TI  - Physical examination. Part 12. Chest and lungs.

PMID- 1037678
TI  - Pediatric procedures. The explanation should always come first.

PMID- 1037679
TI  - Blood pressure equipment.

PMID- 1037680
TI  - Individualized nursing care: how one nurse practitioner succeeded where 20
      doctors had failed.

PMID- 1037681
TI  - Nursing '75 career guide.

PMID- 1037682
TI  - [A window open on nutrition].

PMID- 1037684
TI  - [Headache].

PMID- 1037683
TI  - [Hospital administration: positive participation by nurses in the Administrative
      Council].

PMID- 1037685
TI  - [A day center for diabetics].

PMID- 1037686
TI  - Digitalis-induced accelerated idioventricular rhythms: revisited.

PMID- 1037687
TI  - A study in ventricular fusion.

PMID- 1037688
TI  - Acute exacerbation of dyspnea in a COPD patient.

PMID- 1037689
TI  - Cardiac pacemakers. III. Pacemakers in the management of reciprocating
      tachycardias.

PMID- 1037690
TI  - Editorial: Defining nursing titles and their meaning.

PMID- 1037691
TI  - Flexibility in medical writing.

PMID- 1037692
TI  - The Royal infirmary of Edinburgh Symposium: some aspects of coronary disease.

PMID- 1037693
TI  - Events surrounding an acute heart attack. Community aspects of instable angina
      and the acute heart attack.

PMID- 1037694
TI  - The metabolic responses to a heart attack.

PMID- 1037695
TI  - Anticoagulant therapy in myocardial infarction.

PMID- 1037697
TI  - Letter: New approach to intractable ascites: peritoneo-atrial shunt.

PMID- 1037696
TI  - Coronary arteriography and left-heart studies.

PMID- 1037698
TI  - Getting the most from mutual funds.

PMID- 1037699
TI  - More on informed consent.

PMID- 1037700
TI  - Editorial: the hospital administrator.

PMID- 1037701
TI  - Editorial: Beyond the science: III. Prayer of a Hebrew physician.

PMID- 1037702
TI  - The osteopathic management of trigeminal neuralgia.

PMID- 1037703
TI  - Needle aspiration of renal masses.

PMID- 1037704
TI  - The serum digoxin level: its significance in clinical practice.

PMID- 1037705
TI  - Trauma: a neglected cause of cephalgia.

PMID- 1037706
TI  - Acute pediatric abdomen: report of a case of ovarian tumor.

PMID- 1037707
TI  - Cryocautery in the treatment of cervical condyloma acuminatum: a case report.

PMID- 1037708
TI  - Thermography of the back in asymptomatic subjects.

PMID- 1037709
TI  - Effects of freezing rate on the post-thaw survival of mammalian cells.

PMID- 1037710
TI  - Preliminary study: an evaluation of the effects of osteopathic manipulative
      therapy on intraocular pressure.

PMID- 1037711
TI  - Estimation of methylglyoxal level in normal and neoplastic tissues: II.
      Presentation of data.

PMID- 1037712
TI  - Control of creatine phosphokinase isoenzyme development during myogenesis in
      vitro.

PMID- 1037713
TI  - The invitro effects of lithium chloride on electrolyte balance in L-929 cells.

PMID- 1037714
TI  - Mechanism of protection of mice against vaccinia virus by bacterial allergy.

PMID- 1037715
TI  - Alternatives to the strike in collective bargaining.

PMID- 1037716
TI  - Some practical statistical procedures.

PMID- 1037717
TI  - Job interviewing: an effective tool for hiring staff nurses.

PMID- 1037718
TI  - An intersystem perspective for ambulatory care program management.

PMID- 1037719
TI  - Problem solving through "process management".

PMID- 1037720
TI  - The influence of cultural heritage on the health status of Puerto Ricans.
AB  - The problems of poor health among Puerto Ricans today are compounded by their
      cultural traditions. Many Puerto Ricans still rely on folk medicine to cure their
      ills. One study by Suchman found that compared with persons of other ethnic
      groups in New York City, the Puerto Ricans are more suspicious of scientific
      medical care, tend to use general health services less, have more limited health
      horizons than any other ethnic group. Aside from the unsophisticated health
      practices stemming from a knowledge of Puerto Rican folk medicine, the cultural
      phenomena of spiritualism plays a significant role in retarding the health status
      of the Puerto Rican. Puerto Ricans who view illness as possession by evil spirits
      will consult a medium or curandero(a) for treatment instead a physician. The hot
      and cold theory of disease has a profound influence on the Puerto Ricans' health
      status. In the attempt to achieve equilibrium of the four body humors, Puerto
      Ricans will often disregard a physician's advice which does not conform to this
      theory. Also, machismo, the concept of male dominance and superiority leads to
      sexual promiscuity, over-population, venereal disease, family breakdown, early
      marriage, and a variety of health related problems.

PMID- 1037721
TI  - Social class differences in family attitudes: "are the diminishing among young
      people?".

PMID- 1037722
TI  - Research and the future of health education.

PMID- 1037723
TI  - A classroom comparison of behavioral modification techniques.

PMID- 1037724
TI  - Venereal disease education: facts are not enough.

PMID- 1037725
TI  - Letter to the editor: Chiropractic: a challenge for health education.

PMID- 1037726
TI  - Reducing smoking using positive self-management.

PMID- 1037728
TI  - Rx for RN retirement.

PMID- 1037727
TI  - She asked: "Am I going crazy?".

PMID- 1037729
TI  - Looking out for complications of abdominal surgery.

PMID- 1037730
TI  - Nurse's notes: that's where the goodies are!

PMID- 1037731
TI  - Dangers of accepting stereotypes: a boy taught me about nonacceptance.

PMID- 1037732
TI  - What patients' actions tell you about their feelings, fears and needs.

PMID- 1037733
TI  - Standing orders for the school nurse.

PMID- 1037734
TI  - Breaking through the blues.

PMID- 1037735
TI  - Tax breaks for nurses.

PMID- 1037736
TI  - The movement of an unemulsified oil test meal and aqueous- and oil-phase markers
      through the intestine of normal and bile-diverted rats.
AB  - An unemulsified oil test meal containing aqueous- and oil-phase markers (PEG and
      3-H labelled triether) was fed to control and bile fustula rats. PEG moved ahead
      of the lipid phase in all groups, and was of limited value as a marker for the
      test meal. Triether was an excellent marker for studies of gastric emptying. An
      unexpectedly high correlation was seen between the triether and the test meal and
      its digestion products in the intestine. The results suggest that triether is a
      valid marker for following the movement of lipid through the bowel under the
      conditions of this study. Triether/fat ratios indicated that fat absorption
      occurred largely from the upper small bowel in control animals and from the lower
      small bowel in the absence of bile. Bile diversion resulted in more rapid gastric
      emptying initially, but very slow gastric emptying of the last part of the oil
      test meal. Intestinal transit of test meal or either marker was not significantly
      affected by bile diversion. No evidence for a direct effect of bile diversion on
      gastrointestinal motility was found.

PMID- 1037737
TI  - Separation of the placenta in the ewe: an ultrastructural study.
AB  - Placental separation in the ewe appears to involve an explosive degeneration of
      the chorionic epithelium which occurs in the short space of time between
      parturition and the delivery of the fetal membranes. In the goat there is a
      similar mechanism of separation. By contrast separation of the placenta in the
      cow appears to depend upon a detachment at the junctional region between fetal
      and maternal epithelia. There is no obvious explanation for these findings. The
      results are discussed in the light of the placental hormonal environment in the
      period which immediately precedes parturition.

PMID- 1037738
TI  - Calcium transport by the chick chorioallantois in vivo.

PMID- 1037739
TI  - 19 steps to cardiac rehabilitation.

PMID- 1037740
TI  - The aging face.

PMID- 1037741
TI  - Rhytidectomy in the male.

PMID- 1037743
TI  - Getting a college degree for what you know.

PMID- 1037742
TI  - Traumatic injuries of the diaphragm.

PMID- 1037744
TI  - Orthopedic nursing. Part 1. Easing the burden of traction and casts.

PMID- 1037745
TI  - How the nonprofessional views the R.N.

PMID- 1037746
TI  - When your patient suffers a seizure.

PMID- 1037747
TI  - Defamation: a rash comment could get you sued.

PMID- 1037748
TI  - Electrolyte imbalance: how to recognize and respond to it. Part 1.

PMID- 1037749
TI  - The pregnant patient: treating her without harming the baby.

PMID- 1037751
TI  - Managing your money. Nostalgia transforms junk into treasures.

PMID- 1037750
TI  - Pulmonary TB: not quite a disease of the past.

PMID- 1037752
TI  - Power, freedom and professional practice in nursing.

PMID- 1037753
TI  - Evaluation of nursing care: a primary nursing project. Part 1. Report of the
      controlled study.

PMID- 1037754
TI  - Evaluation of nursing care: a primary nursing project. Part 2. Experiences of non
      participant nurse observers.

PMID- 1037755
TI  - Supervisor overseas: male midwives in U.K.?

PMID- 1037756
TI  - Editorial: The love--hate syndrome.

PMID- 1037757
TI  - Law for the nurse supervisor; informed consent.

PMID- 1037758
TI  - An efficient method for producing slide reproductions of radiographs.

PMID- 1037759
TI  - Some things we wanted to know about you and weren't afraid to ask.

PMID- 1037760
TI  - Cutaneous horn in a laboratory rat.

PMID- 1037761
TI  - Unilateral patagiectomy: a technique for deflighting large birds.

PMID- 1037762
TI  - A case of systemic lupus erythematosus in a dog.

PMID- 1037763
TI  - Tyzzer's disease in an adult cat.

PMID- 1037764
TI  - Malignant lymphoma, a disease entity.

PMID- 1037765
TI  - Use of glyceryl guaiacolate ether in treating strychnine poisoning in the dog.

PMID- 1037766
TI  - Experimental design of clinical trials testing the efficacy of 90% DMSO solution
      in injuries to the musculoskeletal system in the dog.

PMID- 1037767
TI  - Typical colobomas in Charolais cattle.

PMID- 1037768
TI  - Anthelimintic efficacy of dichlorvos against Hyostrongylus rubidus and
      Oesophagostomum dentatum in swine at timed intervals after exposure to infective
      larvae.

PMID- 1037769
TI  - Prevention of sudden death caused by Clostridium sordellii in feedlot cattle.

PMID- 1037770
TI  - Mycotic rumenitis in cattle.

PMID- 1037771
TI  - Perforated ulcer in the small intestine of a mare.

PMID- 1037772
TI  - Cryosurgery for removal of equine sarcoids.

PMID- 1037773
TI  - Use of the hoof tester in diagnosing lameness in horses.

PMID- 1037774
TI  - How to evaluate your investments.

PMID- 1037775
TI  - Problems in providing goods and/or services to minors.

PMID- 1037776
TI  - Programmed instruction. Patient assessment: examination of the eye, part 2.

PMID- 1037777
TI  - Watching your finances: what is your net worth?

PMID- 1037778
TI  - Changing to an automated information system.

PMID- 1037779
TI  - The intra-aortic balloon pump.

PMID- 1037780
TI  - Preparing a patient for EEG.

PMID- 1037781
TI  - Relieving gas pains.

PMID- 1037782
TI  - Birthright--alternative to abortion.

PMID- 1037783
TI  - Multiple myeloma.

PMID- 1037784
TI  - Nurses' rights.

PMID- 1037785
TI  - Group therapy for preadolescent boys.

PMID- 1037786
TI  - Editorial: The vigil.

PMID- 1037787
TI  - Thoughts from an artificial nurse.

PMID- 1037788
TI  - Sexual function in traumatic paraplegia and quadriplegia.

PMID- 1037789
TI  - Adding retrospective audit.

PMID- 1037790
TI  - Suicide.

PMID- 1037791
TI  - Suicide in relation to time of day and day of week.

PMID- 1037792
TI  - PEG and angiography: a patient's sensations.

PMID- 1037793
TI  - Primary care by a nurse practitioner in a rural clinic.

PMID- 1037794
TI  - Cathartics.

PMID- 1037795
TI  - Widowhood.

PMID- 1037796
TI  - Innovative continuing education in small hospitals.

PMID- 1037797
TI  - Taft-Hartley amended: implications for nursing. The industrial model.

PMID- 1037798
TI  - Taft-Hartley amended: implications for nursing. The professional model.

PMID- 1037799
TI  - Taft-Hartley amended: implications for nursing. Conflict and conflict resolution.

PMID- 1037800
TI  - Watching your finances: why consider the government market?

PMID- 1037801
TI  - Packaging materials for EO gas sterilization.

PMID- 1037802
TI  - Some answers to common queries about CE issues.

PMID- 1037803
TI  - Do patients need OR staff nurses?

PMID- 1037804
TI  - Are current skin preparations valid?

PMID- 1037805
TI  - Restoration of hand function.

PMID- 1037806
TI  - Reconstructive hand surgery.

PMID- 1037807
TI  - Blepharoplasty for baggy eyelids.

PMID- 1037808
TI  - [Student nurses in education; experiences of the Hamburger learners' study].

PMID- 1037810
TI  - [Standing committee for nursing in relation to the European Economic Community].

PMID- 1037809
TI  - [Opinions on the drafting of legislation concerning non-medical health
      occupations in midwifery and nursing].

PMID- 1037811
TI  - [European Nursing Society].

PMID- 1037812
TI  - [Stepwise rehabilitation].

PMID- 1037813
TI  - [Report on a preceptorship in House Hammer - a sheltered workshop of the city
      Kiel].

PMID- 1037814
TI  - [Against abolishment of suffering].

PMID- 1037815
TI  - [Infantile autism].

PMID- 1037816
TI  - [Clinical rehabilitation of hemiplegics. Etiology and criteria for differential
      diagnosis of a stroke and symptoms of hemiplegia].

PMID- 1037817
TI  - [Principles of drug therapy: analgesics, antipyretics and tranquilizers].

PMID- 1037818
TI  - [Hereditary flexion contractures of the fingers].

PMID- 1037819
TI  - [Innovations in resuscitation].

PMID- 1037820
TI  - [Training of female and male operating room nurses in the city hospital of
      Ludwigshafe/Rhein].

PMID- 1037821
TI  - [Opinions on the drafting of legislation concerning non-medical health
      occupations in midwifery and nursing].

PMID- 1037822
TI  - [Should a mother of infants or toddlers be employed?].

PMID- 1037823
TI  - [Preventive studies in pneumonology].

PMID- 1037824
TI  - [Roentgen diagnosis of the breast in preventive diagnostic studies].

PMID- 1037825
TI  - [Management in nursing service].

PMID- 1037826
TI  - [The group and its dynamics].

PMID- 1037827
TI  - [Opinions on the drafting of legislation concerning non-medical health
      occupations in midwifery and nursing].

PMID- 1037828
TI  - [Local skin abnormalities in infants and toddlers].

PMID- 1037829
TI  - [Letter: Antibacterial treatment of chronic cholangitis].

PMID- 1037830
TI  - A Canadian educational programme in family practice nursing.

PMID- 1037832
TI  - Psychiatric problems and services in Kenya.

PMID- 1037831
TI  - A glimpse of the nursing profession in Morocco.

PMID- 1037833
TI  - Automation of the health care system: implications for nursing. Part 1. Dangers
      to nursing practice in the automation of the health care system.

PMID- 1037834
TI  - Planning your estate.

PMID- 1037835
TI  - Nonsurgical removal of intracardiac polyethylene catheter emboli.

PMID- 1037836
TI  - Coronary arterial anomalies.

PMID- 1037837
TI  - Primary hemangiosarcoma of the spleen with sarcomatosis.

PMID- 1037838
TI  - An electrodiagnostic survey of patients with diabetes mellitus utilizing
      determinations of motor nerve conduction velocity.

PMID- 1037840
TI  - Training of medical students in computerized statistical analysis of
      cardiovascular-respiratory data after exercise. III. Summary of statistical
      significance.

PMID- 1037839
TI  - Hypertension in pregnancy: normal and abnormal renal function.

PMID- 1037841
TI  - Aortic nascent histamine in neurogenic and aortic coarctation induced
      hypertension: effect on arterial permeability.

PMID- 1037842
TI  - A ladder for clinical advancement in nursing practice: implementation.

PMID- 1037843
TI  - Effecting change.

PMID- 1037844
TI  - Management by objectives: antidote to future shock.

PMID- 1037845
TI  - The pleasures and problems of the director of nursing in a small hospital.

PMID- 1037847
TI  - Letters: PERT: a tool for nurse administrators.

PMID- 1037846
TI  - Nurses' right to strike.

PMID- 1037848
TI  - Interpersonal feedback: a cost-benefit analysis.

PMID- 1037849
TI  - Letter: Leadership development at the clinical unit level.

PMID- 1037850
TI  - Letter: The R.N. problem: returning to active practice.

PMID- 1037851
TI  - [Rights of the midwife].

PMID- 1037852
TI  - [Working women and their welfare as an objective of midwifery services].

PMID- 1037853
TI  - [Obstetrical problems of working women].

PMID- 1037854
TI  - [Obstetrical care at the place of employment].

PMID- 1037856
TI  - [Problems of maternal welfare of midwives].

PMID- 1037855
TI  - [Statistical observation of maternal care of working women].

PMID- 1037857
TI  - [Discussion: Maternal care of working women].

PMID- 1037858
TI  - [Maternal leave of nurses and its effects on the work situation].

PMID- 1037859
TI  - [Survey on working women and their menstruation disorders].

PMID- 1037860
TI  - [Impression on the 15th Congress on Maternal Hygiene].

PMID- 1037861
TI  - [Impression on the Obstetrical and Pediatric Sections of the 5th Congress of the
      Japan Nursing Association].

PMID- 1037862
TI  - [Mechanism of labor pain].

PMID- 1037863
TI  - [Treatment of cancer of the corpus uteri with luteal hormone].

PMID- 1037865
TI  - [Liver diseases in infants].

PMID- 1037864
TI  - [Obstetrical care in Nepal].

PMID- 1037866
TI  - [Human morphology and somatotypes. 8].

PMID- 1037867
TI  - [Nursing training as a form of education: A theory of nursing education].

PMID- 1037868
TI  - [Diagnosis of severe neonatal jaundice - clinical symptoms, diagnostic tests and
      differential diagnosis].

PMID- 1037869
TI  - [Team nursing at our hospital: the present status and its future problems. 1].

PMID- 1037870
TI  - [Treatment of neonatal jaundice: exchange transfusion and intrauterine
      transfusion].

PMID- 1037871
TI  - [Treatment of severe jaundice: light therapy].

PMID- 1037872
TI  - [Severe neonatal jaundice: chemotherapy].

PMID- 1037874
TI  - [Bedside care of severe neonatal jaundice: nursing care during light therapy].

PMID- 1037873
TI  - [Bedside care of severe neonatal jaundice: nursing of infants with severe
      jaundice in the intensive care unit].

PMID- 1037875
TI  - [Bedside care of severe neonatal jaundice: management of neonatal jaundice].

PMID- 1037876
TI  - [Bedside care of severe neonatal jaundice: cases of monozygotic twins].

PMID- 1037877
TI  - [Bedside care of severe neonatal jaundice: nursing of a premature infant with low
      birth weight and hyperbilirubinemia].

PMID- 1037878
TI  - [Physiology and pathology of neonatal jaundice - the etiological mechanism and
      classification].

PMID- 1037879
TI  - [Prognosis of severe neonatal jaundice - a follow-up study of exchange
      transfusion].

PMID- 1037880
TI  - [Current status and problems of home dialysis in Nagoya City].

PMID- 1037881
TI  - [Regional health care and the practice of hemodialysis - analysis of hemodialysis
      care in Nagano Prefecture].

PMID- 1037882
TI  - [Team nursing at our hospital - current status and future problems. 2].

PMID- 1037883
TI  - [Safety in hemodialysis and key points in monitoring].

PMID- 1037884
TI  - [Nutrition and the diet of patients receiving hemodialysis therapy for an
      extended period].

PMID- 1037885
TI  - [Basis of nursing of chronic hemodialysis patients - dialysis therapy and the
      role of nursing].

PMID- 1037886
TI  - [Indication and practice of peritoneal dialysis - a comparison with
      hemodialysis].

PMID- 1037887
TI  - [Practice of nursing of dialysis patients at the kidney center].

PMID- 1037888
TI  - [Nursing of an aged patient at the initiation of hemodialysis].

PMID- 1037889
TI  - [Nursing activities for ambulatory hemodialysis patients].

PMID- 1037890
TI  - [Nursing of chronic hemodialysis patients treated at the outpatient clinic, with
      a special consideration on their psychological states].

PMID- 1037891
TI  - [Physiopathology of chronic kidney failure and the theory of hemodialysis].

PMID- 1037892
TI  - [Observation on nursing and chronic dialysis].

PMID- 1037893
TI  - [Report by the Committee on Nursing Education of the Japan Nursing Association.
      (6). A study on the educational goal in nursing education].

PMID- 1037894
TI  - [Clinical training in symptomatic nursing at our school].

PMID- 1037895
TI  - [Theories and methodology in the study of personality development. 4. Personality
      development and guidance (3)].

PMID- 1037897
TI  - [Future of nursing education].

PMID- 1037896
TI  - Interest in learning (1).

PMID- 1037898
TI  - [Discussion: Impression on the status of Japanese nursing education].

PMID- 1037899
TI  - [My theory of nursing education. 2. The fault of nursing education without
      emphasis on students' personality development].

PMID- 1037900
TI  - [Re-evaluation of educational technics. (2). Educational method with emphasis on
      development of individual student's potentials].

PMID- 1037901
TI  - [Report by the Committee on Nursing Education of the Japan Nursing Association.
      (5). Significance of clinical training and its curriculum planning for the basic
      nursing course].

PMID- 1037903
TI  - [Re-evaluation of educational methods (3). Teaching method for the purpose of
      developing students' aptitude].

PMID- 1037902
TI  - [A personal history of a nursing instructor].

PMID- 1037905
TI  - [Report by the Committee on Nursing Education. Japan Nursing Association. (8). Re
      evaluation of education of public health nursing].

PMID- 1037904
TI  - [Report by the Committee on Nursing Education, Japan Nursing Association. (7) A
      survey on students entering nursing schools: 3-year-course nursing schools and
      their students].

PMID- 1037906
TI  - [Evaluation of the curriculum with a greater emphasis on clinical training].

PMID- 1037907
TI  - [Nursing education in China].

PMID- 1037908
TI  - [Theory of personality development and the methodology of its study. 5.
      Integration of past experiences in personality development].

PMID- 1037909
TI  - [Interest in learning (2)].

PMID- 1037910
TI  - [Discussion: Regional nursing activities by public health nurses].

PMID- 1037911
TI  - [Evaluation of public health nursing activities in a small population group.
      Realistic observation of nutritional state of patients].

PMID- 1037912
TI  - [On the Health Visitors' Association in Great Britain].

PMID- 1037913
TI  - [Chronically ill patients and their demands on nurses. (1)].

PMID- 1037914
TI  - [Utilization of the system of registering premature infants for the purpose of
      providing them with special postnatal care].

PMID- 1037915
TI  - [Public health nursing activities in cooperation with local hospitals].

PMID- 1037916
TI  - [Follow-up survey of health examinations of 3-year-olds].

PMID- 1037917
TI  - [A follow-up study of small-for-date infants in the district assigned to Hayato
      Health Clinic, Kagoshima Pref. (1)].

PMID- 1037918
TI  - Cloning of the nurse educator: is she more involved in clinical care?

PMID- 1037919
TI  - VD, the equal opportunity disease. Part I. This is VD too? Moniliasis,
      trichomoniasis vaginalis, herpes simplex, condylomata accuminata.

PMID- 1037920
TI  - VD, the equal opportunity disease. Part II. The "social diseases". Gonorrhea and
      syphilis.

PMID- 1037921
TI  - Dual-purpose tool for assessing maternal needs and nursing care.

PMID- 1037922
TI  - Iron-deficiency anemia: how long must it be with us?

PMID- 1037923
TI  - For high-risk infants and their parents: postnatal discussion groups and well
      baby clinics operate in storefront.

PMID- 1037924
TI  - Whatever happened to prepared childbirth?

PMID- 1037925
TI  - A practitioner's guide to utilization of research findings.

PMID- 1037926
TI  - [Discussion: a comprehensive evaluation of medical care in Japan - a humane
      approach needed in nursing].

PMID- 1037927
TI  - [Aged patients and nursing].

PMID- 1037928
TI  - [Questions and answers in psychiatric nursing].

PMID- 1037930
TI  - [On the nursing course leading to college education. 8. A thought at the new
      year].

PMID- 1037929
TI  - [Japanese economy and citizens' lives: economic inconsistency brought about by
      the rapid economic growth].

PMID- 1037931
TI  - [Life science: medicine and man. Privacy of health personnel and patients].

PMID- 1037932
TI  - [Discussion: The role of local clinics - re-evaluation of the importance of their
      contact with local citizens].

PMID- 1037933
TI  - [Psychological impact of aging].

PMID- 1037934
TI  - [Understanding of patients through conversation].

PMID- 1037935
TI  - [Status and problems of agriculture in Japan].

PMID- 1037936
TI  - [Nursing course preparatory to university education. Preparation for the entrance
      examination].

PMID- 1037937
TI  - [Life science: medicine and man. Potential dangers involved in the use of the
      terms, "society" and "socialization"].

PMID- 1037939
TI  - Continuing education for R.N.s. The means to separate the professional from the
      parasite.

PMID- 1037938
TI  - Institutional licensure.

PMID- 1037940
TI  - Nursing: eight years to oblivion?

PMID- 1037941
TI  - Report of a visit to Russia.

PMID- 1037942
TI  - Nursing education programs.

PMID- 1037943
TI  - Continuing education and its ramifications.

PMID- 1037944
TI  - A sex information program for sexually active teenagers.

PMID- 1037945
TI  - Increasing in-school emphasis on nutrition.

PMID- 1037946
TI  - Restyling the grade in health education.

PMID- 1037947
TI  - The mental health of students--do teachers hurt or help?
AB  - Students' problems of adjustment are serious, and merit attention. Teachers who
      are so inclined could help prevent many emotional problems by applying some
      methods and attitudes of psychotherapists. It is appropriate for them to avoid
      such tactics, as threat, shame, and sympathy, and adopt such skills and attitudes
      as acceptance, empathy, genuineness, and relevancy.

PMID- 1037948
TI  - Differences in mean adolescent blood pressure by age, sex ethnic origin, obesity
      and familial tendency.
AB  - The researcher used the analysis of variance and the uncorrelated t-test to
      determine the significant differences between age, sex, obesity, race, and
      familial tendency in systolic and diastolic blood pressures for 496 randomly
      chosen adolescent subjects. Significance was found in the differences between the
      systolic blood pressure by sex, obesity and race. Mean values were presented for
      the systolic and diastolic blood pressure by sex, age, and ethnic origin.

PMID- 1037949
TI  - Breakfast and today's lifestyles.

PMID- 1037950
TI  - Sex education programs and the mentally retarded.

PMID- 1037951
TI  - Behavior modification and values clarification and their research implications.

PMID- 1037952
TI  - Development of an investigatory instrument to measure attitudes toward death.

PMID- 1037953
TI  - The treatment of an abused family.

PMID- 1037954
TI  - Use of humor by an immobilized adolescent girl during hospitalization.

PMID- 1037955
TI  - The impact of a boy's head injury on his parents.

PMID- 1037956
TI  - A mother's grief work following the death of her deformed child.

PMID- 1037957
TI  - Rumination in a failure-to-thrive infant.

PMID- 1037958
TI  - Toward self-fulfillment of the graduate nurse.

PMID- 1037959
TI  - Grappling with reality.

PMID- 1037960
TI  - [Women's year].

PMID- 1037961
TI  - [Midwifery today].

PMID- 1037962
TI  - [Nursing law].

PMID- 1037964
TI  - The dying patient: meeting his needs could be easier than you think.

PMID- 1037963
TI  - Communication disorders in children: a guide for detection and referral.

PMID- 1037965
TI  - Conquering those obstinate decubiti. Foam leg supports.

PMID- 1037966
TI  - Conquering those obstinate decubiti. The screen box.

PMID- 1037967
TI  - Larry thought puppet-play "childish." But it helped him face his fears.

PMID- 1037968
TI  - Epidural hematoma; nurses lead a winning team effort. Nursing grand rounds.

PMID- 1037969
TI  - Emergency! Part 2: First aid for open wounds, severe bleeding, shock, and closed
      wounds.

PMID- 1037970
TI  - Hodgkin's disease... the curable cancer. Part 1. Diagnosis and treatment.

PMID- 1037971
TI  - Hodgkin's disease: hope is the key to nursing care. Part 2. Nursing needs.

PMID- 1037972
TI  - Helping the survivors of expected death.

PMID- 1037973
TI  - JCAH standards for nursing audits.

PMID- 1037974
TI  - Laws of consent.

PMID- 1037975
TI  - Exercise; how to use it to decrease complications in immobilized patients.

PMID- 1037976
TI  - Motivating a staff plagued by failures.

PMID- 1037977
TI  - Turning a staff into a team.

PMID- 1037978
TI  - Listening.

PMID- 1037979
TI  - Pulmonary embolism.

PMID- 1037980
TI  - [A new threat in an old enemy].

PMID- 1037982
TI  - Perivascular ulcerations.

PMID- 1037981
TI  - The current status of electrically stimulated bone growth.

PMID- 1037983
TI  - Fat embolism syndrome.

PMID- 1037984
TI  - Who cares?

PMID- 1037985
TI  - A simple understanding of a laminar flow clean room.

PMID- 1037986
TI  - ["Steel nurse"; discussion about a mechanical patient lift].

PMID- 1037987
TI  - [Communication in the hospital].

PMID- 1037989
TI  - [Care of the elderly].

PMID- 1037988
TI  - [Report on the clinical instructor in England].

PMID- 1037990
TI  - [Anthropological observations on the problem: truth at the sickbed].

PMID- 1037991
TI  - [Coordination of functions of various professional staff in the hospital].

PMID- 1037992
TI  - [Campaign against increasing costs in the hospital].

PMID- 1037993
TI  - [Old age--a problem for the entire society].

PMID- 1037994
TI  - Experiential learning: application to teaching rehabilitation nursing.

PMID- 1037995
TI  - Health teaching: an approach for the diploma student.

PMID- 1037996
TI  - Strategies for effective teaching.

PMID- 1037998
TI  - Psychiatric nursing--relevancy to total nursing care.

PMID- 1037997
TI  - Helping students learn maternal-child health nursing.

PMID- 1037999
TI  - Teaching psychiatric nursing.

PMID- 1038000
TI  - Integration of psychiatric nursing into the total program.

PMID- 1038001
TI  - Oral examinations--a new perspective on nursing evaluations.

PMID- 1038002
TI  - The instructor--a facilitator of learning.

PMID- 1038003
TI  - Independent study project for seniors.

PMID- 1038004
TI  - Assisting students with educational deficiencies.

PMID- 1038005
TI  - Nursing behaviors responsive to organic problems of the patient. No. 16-1538.

PMID- 1038006
TI  - Restlessness: a nursing phenomenon in search of meaning.

PMID- 1038007
TI  - An articulated nursing program: five years later.

PMID- 1038008
TI  - Student - family contracts.

PMID- 1038009
TI  - Where do you start?

PMID- 1038010
TI  - Editorial: The stuff of which nursing is made.

PMID- 1038011
TI  - A diagnostic classification system for nursing.

PMID- 1038012
TI  - Developing a nursing diagnosis.

PMID- 1038013
TI  - Clinical practicum before graduation.

PMID- 1038014
TI  - Changes in students' knowledge and attitudes following a course in human
      sexuality: report of a pilot study.
AB  - Eleven female undergraduate nursing students and 12 male undergraduates from a
      private southern university responded to a 163-item questionnaire, the Human
      Sexuality Knowledge and Attitude inventory, prior to and immediately following a
      formal course in human sexuality. The results of a pilot test indicated that
      improvement in respondents' total knowledge score (TOTSC) was correlated with
      completion of the course. No correlation existed between liberalization of
      attitudes toward sexuality and completion of the course. Demographic variables of
      age, sex, perception of self as "somewhat" or "slightly religious" and "somewhat
      liberal politically", and residence in small cities in the New England/Middle
      Atlantic area were significantly correlated with improvement of TOTSC.
      Demographic variables did not appear to affect liberalization of attitudes. The
      investigators concluded that the course is an effective model for assisting
      students to accumulate a knowledge base about sexuality. Although attitudinal
      change was not an immediate outcome of the course, perhaps this variable will
      change on a long-term basis.

PMID- 1038015
TI  - A role-playing simulation approach toward studying nurses' decisions to listen to
      patients.
AB  - To test a methodology that used role-playing responses by nurses to simulated
      patient disclosures, a three-part investigation was carried out at Vanderbilt
      University, Nashville, Tennessee. Four simulated patients-with diagnoses of
      diabetes mellitus, alcoholism with bleeding ulcer, ulcerative colitis, and cancer
      of the large intestine-tape recorded 20- to 30-second segments on 12 topics
      pertaining to their illness. Six topics dealt with the patients' physical
      problems; six with psychological aspects of the problems. In the tests for
      nurses' willingness both to listen and to pass along information to the next
      nurse, the 48 tape-recorded segments of patient information were played for 16
      volunteer nurses in a laboratory set up for the purpose. Although the nurses had
      an option of listening or preparing a medication, they were expected to listen to
      at least 16 of the 48 segments. Following this, they were asked to tape record a
      report on the patient for the nurse who would follow them. The nurses, on
      average, listened to 29 of the 48 segments. The diabetic patient was listened to
      least; the cancer and the colitis patients each received a similar amounts of
      attention. The nurses gave substantial amounts of information as well as
      interpretive data about the patients so that the methodology seemed to prove that
      nurses could become sufficiently involved in a simulated patient setting.

PMID- 1038016
TI  - Increasing nursing students' interest on working with aged patients.
AB  - The Tuckman-Lorge Attitude questionnaire, which measures stereotypes and
      misconceptions about the aged, was administered to 311 baccalaureate nursing
      students who were also asked to indicate their relative preferences for various
      fields of specialization within nursing and their preferences for working with
      child, adult, and elderly patients. The study was designed to examine factors--a
      two-semester course in human development and aging, visits with a physically
      "well" older person living in the community, attitudes toward the aged, and
      several biographic factors--associated with increased interest in working with
      elderly patients. Findings included: Students showed minimal interest in working
      in nursing homes; they preferred to work with child and adult patients. The more
      stereotyped their thinking about the aged, the greater their interest in working
      with ederly patients. Students who previously worked in a nursing home or
      convalescent hospital showed greater willingness to work with elderly patients.
      The authors suggest that schools of nursing include gerontology in their
      curriculums and that nursing students be provided with clinical experience in
      institutions for the aged to acquaint them with, and to encourage interest in,
      this increasingly important field of specialization.

PMID- 1038017
TI  - Increasing the quality of nursing care by introducing the concept of primary
      nursing: a model project.
AB  - To ascertain the extent and degree of skill with which nurses have carried out
      processes judged to represent good nursing care, two alternate approaches were
      tested to organize the delivery of nursing care to children: Nurses on an
      experimental unit were trained to use primary care, that is, assignment of six to
      eight patients to one nurse who was responsible for the planning, implementation,
      evaluation, and coordination of the nursing care until the patient's discharge.
      On a control unit, nurses participated in delivery of group care, so that the
      care of each patient was assigned to various nurses. Performance of the nursing
      care was measured by the Slater Nursing Competencies scale, the Quality Patient
      Care scale, and the Phaneuf Nursing Audit. Mean scores on the three instruments
      were found to be higher on the experimental unit.

PMID- 1038018
TI  - Editorial: The editor's report - 1975.

PMID- 1038019
TI  - Effect of brief training on mental health knowledge and attitudes of nurses and
      nurses' aides in a general hospital.
AB  - A six-week psychiatric nursing training program for professional nurses (N equals
      15) and nurses' aides (N equals 14) in a stage general hospital setting resulted
      in significant improvement in both training groups on psychiatric nursing
      knowledge. No statistically significant change in mental health attitudes was
      found on the Opinions about Mental Illness (OMI) scale in the nurse group but a
      significant reduction in social restrictiveness was revealed in the nurses' aide
      group. No significant change in knowledge or attitudes was found in a matched
      control group of nurses' aides (N equals 14).

PMID- 1038020
TI  - Associate degree nursing students: nonintellective differences between dropouts
      and graduates.
AB  - A comprehensive battery of tests designed primarily to measure nonintellective
      characteristics was administered to 112 students entering five associate degree
      nursing programs. At the end of two years, analyses of the entrance data revealed
      significant differences between the 73 graduates (those who completed the program
      on schedule) and the 32 nongraduates (those who dropped our of the program for
      various reasons). Seven students who remained in the programs but who had not
      completed the requirements were not included in the analyses. The data indicated
      that at the time of entry into their programs, those students who later completed
      the program on schedule were more mature--older and married, more achievement
      oriented, responsible, and self-controlled than dropouts. Successful students
      also manifested more accepting and nonjudgmental attitudes toward other people.

PMID- 1038021
TI  - Development of an instrument to measure patient satisfaction with nurses and
      nursing care in primary care settings.
AB  - An instrument that evaluated patient attitudes toward nurses and nursing care in
      a primary care setting is described. The tool consists of 25 items, subdivided
      into three subscales--1) technical-professional area, 2) interpersonal
      educational relationship, and 3) interpersonal trusting relationship--to which
      respondents indicate agreement to disagreement in five Likert-type steps. Items,
      developed from interviews with patients, literature review, and other similar
      scales, were submitted to two sequential trials and to application of criteria
      such as variability, representativeness of content definition, ability to
      discriminate between respondents, and internal consistency. Respondents for the
      two sequential trials were 78 and 60 patients of internists or general
      practitioners at a group health cooperative. Scott's homogeneity ratios and
      reliability coefficients as measured by Cronbach's alpha were obtained for the
      subscale and the total scale, and subscale intercorrelation coefficients were
      determined, but further testing of the scale for validity is needed.

PMID- 1038022
TI  - Team teaching: advantages and disadvantages to the student.
AB  - To test an instrument for its ability to identify advantages and disadvantages of
      team teaching in baccalaureate nursing education, a questionnaire was given to 97
      undergraduate nursing students from two colleges who had experienced similar team
      teaching experiences. Distinct advantages and disadvantages of team teaching were
      identified.

PMID- 1038023
TI  - Why associate degree nursing students persist.
AB  - A study of 120 associate degree nursing (ADN) students at Illinois Central
      College during 1972-1973 tested the hypothesis that there will be no
      statistically significant difference in certain measured personality factors of
      the persister compared with the dropout. The Edwards Personal Preference Schedule
      (EPPS) was used to measure personality characteristics. The null hypothesis was
      rejected for four of the 15 variables measured by the EPPS. Significantly greater
      needs were achievement, deference, and heterosexuality for the persisters and
      abasement for the dropouts. Differences in needs may have resulted from two
      specific focuses of the ADN program: on the problem-solving process based on
      assessment of individual patient's needs and on team nursing which includes both
      the aspects of assuming responsibility for authority and accepting leadership.
      Through their greater need for abasement, the dropouts expressed a need for
      feelings of inferiority, guilt, blame, and inadequacy. Based on the academic
      prerequisites for admission to the ADN program, the dropouts should have
      succeeded. Therefore, it appeared the dropouts had a need to fail or withdraw
      from the program.

PMID- 1038024
TI  - Comparison of student achievement with performance ratings of graduates and state
      board examination scores.
AB  - For a study concerned with investigating relationships between the on-the-job
      performance of 1971 graduates of a diploma school of nursing, their achievements
      as students in the school, and their state board scores, the school's curriculum
      objectives were used in developing an instrument for measuring graduates'
      competence. Findings indicated how well the learning experiences provided by the
      school prepared the students for first-level positions in nursing. The three-year
      cumulative grade point averages and nursing theory and grades were best
      predictors of success on state board examinations, and nursing practice grades
      were best predicators of performance as registered nurses.

PMID- 1038026
TI  - Kids are the nicest people.

PMID- 1038025
TI  - Dorthy B.; Dx: ulcerative colitis.

PMID- 1038027
TI  - Planning the care of the orthopedic patient.

PMID- 1038028
TI  - Read before you pour one more medication.

PMID- 1038029
TI  - Insomnia.

PMID- 1038030
TI  - Cancer detection: a responsibility for every nurse.

PMID- 1038031
TI  - Collective bargaining.

PMID- 1038032
TI  - Sometimes the trouble is so obvious it goes undetected! Dx: poor diet.

PMID- 1038034
TI  - Is patient care too impersonal? You can bring back the human quality by touching.

PMID- 1038033
TI  - How weather affects our health.

PMID- 1038035
TI  - The hysterectomy patient.

PMID- 1038036
TI  - Editorial: Collision course.

PMID- 1038037
TI  - Recent advances in radiotherapy.

PMID- 1038038
TI  - The new Queen Mary's Hospital Sidcup, Kent.

PMID- 1038039
TI  - Reaction to the loss of a limb.

PMID- 1038040
TI  - Practice nurses get together.

PMID- 1038041
TI  - Tablets we don't take.

PMID- 1038042
TI  - Things are not always what they seem.

PMID- 1038044
TI  - Private patients are still patients.

PMID- 1038043
TI  - Nursing care study: rhabdomyosarcoma in a girl of 11.

PMID- 1038045
TI  - Editorial: The ICN--luxury or necessity?

PMID- 1038046
TI  - Manners makyth man.

PMID- 1038047
TI  - Rehabilitation engineering.

PMID- 1038048
TI  - Editorial: Just deserts for paramedicals.

PMID- 1038049
TI  - Lip-service only.

PMID- 1038050
TI  - Management in the reorganised health service. 1. The framework.

PMID- 1038051
TI  - Pre-med panic.

PMID- 1038052
TI  - Termination of pregnancy--the nurse's attitude.

PMID- 1038053
TI  - The care and management of the newborn cleft palate infant.

PMID- 1038054
TI  - Examinations: the concept of objective testing.

PMID- 1038056
TI  - Wasting NHS funds.

PMID- 1038055
TI  - The silver lining.

PMID- 1038057
TI  - The NHS "ombudsman".

PMID- 1038058
TI  - Lifting patients. 1.

PMID- 1038059
TI  - Management in the reorganised health service. 2. Talking the language.

PMID- 1038060
TI  - Only connect.

PMID- 1038061
TI  - A beauty salon in a psychiatric hospital.

PMID- 1038062
TI  - Nurses in Italy.

PMID- 1038063
TI  - Patient reporting.

PMID- 1038064
TI  - Maintenance and repair.

PMID- 1038065
TI  - Multidisciplinary management - a psychiatric nurse's view.

PMID- 1038066
TI  - "Yes, but you're a man".

PMID- 1038067
TI  - Twelve years for patients.

PMID- 1038068
TI  - Editorial: Nursing in the EEC--broadening horizons.

PMID- 1038069
TI  - Dysbarism--a relatively new medical emergency.

PMID- 1038070
TI  - "That wummin".

PMID- 1038071
TI  - Menstrual disorders.

PMID- 1038072
TI  - Management in the reorganised health service. 3. Awkward relations.

PMID- 1038073
TI  - Rehabilitation in psychiatric hospitals. A review of industrial therapy.

PMID- 1038074
TI  - Lifting patients. 2. The shoulder (Australian) lift.

PMID- 1038075
TI  - The clinical nurse specialist.

PMID- 1038076
TI  - "You don't understand, nurse".

PMID- 1038077
TI  - "'Tis not enough to help the feeble up...".

PMID- 1038078
TI  - Listening can be learning and sharing can be studying.

PMID- 1038079
TI  - The computer-an aid to intensive therapy nursing.

PMID- 1038080
TI  - In touch.

PMID- 1038081
TI  - Editorial: Moment of death--brain or heart?

PMID- 1038082
TI  - In-service training of nursing auxiliaries.

PMID- 1038083
TI  - A symposium on the surgery of deafness. Stapedectomy.

PMID- 1038084
TI  - Tympanoplasty.

PMID- 1038085
TI  - Cryosurgery.

PMID- 1038086
TI  - Post office aids for the disabled.

PMID- 1038087
TI  - Another one gone! Were you on duty?

PMID- 1038088
TI  - Management in the reorganised health service. 4. A say for the staff.

PMID- 1038089
TI  - Total patient care assessments of students and pupil nurses during the community
      care option.

PMID- 1038090
TI  - Nursing--present and future trends.

PMID- 1038091
TI  - Lifting patients. 3. The through-arm lift.

PMID- 1038092
TI  - Nursing and counselling-a conflict of roles?

PMID- 1038093
TI  - Euthanasia--a patient's point of view.

PMID- 1038094
TI  - Perinatal deaths and the law.

PMID- 1038095
TI  - Emergency rescue: CCU nurses at the scene via radio.

PMID- 1038096
TI  - Can you spot a "groupy"?

PMID- 1038097
TI  - How to handle that OR clique.

PMID- 1038098
TI  - When your patient's problem involves sex.

PMID- 1038099
TI  - Sexual therapy and nursing--do they mix?

PMID- 1038100
TI  - Orthopedic nursing. Part 2. Preventing orthopedic complications.

PMID- 1038101
TI  - Quality patient care in a couple of minutes? Yes!

PMID- 1038102
TI  - Brain tumors: diagnosis and treatment.

PMID- 1038103
TI  - Leprosy; an ancient scourge--a continuing problem.

PMID- 1038104
TI  - Electrolyte imbalance: how to recognize and respond to it. Part 2.

PMID- 1038105
TI  - Radiopharmaceuticals: nuclear - age drugs for diagnosis and treatment.

PMID- 1038106
TI  - Getting more for your dollars in today's economy.

PMID- 1038107
TI  - [Relationships with difficult persons].

PMID- 1038108
TI  - [Resocialization of paraplegics. Terre des Hommes repatriates Vietnamese children
      from the Federal Republic].

PMID- 1038109
TI  - [Infection hazards in the hospital. I. Hygienic measures in the intensive care
      units and recovery room].

PMID- 1038110
TI  - [Facial clefts].

PMID- 1038111
TI  - [Mentally induced diseases].

PMID- 1038112
TI  - [Typical mechanics on shift work. Psychiatry needs empathic nurses instead of
      procedure nurses - and not only in psychiatry!].

PMID- 1038113
TI  - [A good retirement year].

PMID- 1038114
TI  - [Female nurses tolerate more than male nurses. Hospitals need more female nurses,
      light and color - social service lacking - women in psychiatry].

PMID- 1038115
TI  - [Arthroplastic substitution on the lower extremities].

PMID- 1038116
TI  - [Suicide].

PMID- 1038118
TI  - [Roma locuta, causa finita? Prevention or insensitivity?].

PMID- 1038117
TI  - [Moral and religious aspects in aid to the dying].

PMID- 1038119
TI  - [Greatness and misery of main images in the Hospital. Both staff and patients
      need this - lack in the repertory of human relationships].

PMID- 1038120
TI  - [Another year of Korea].

PMID- 1038121
TI  - [Nurse transforms an orphanage].

PMID- 1038123
TI  - [The hospital minister. Serious and funny experiences of a hospital minister].

PMID- 1038122
TI  - [Treatment of obesity].

PMID- 1038124
TI  - [Teaching hospital].

PMID- 1038125
TI  - Staff education programs on a "shoestring".

PMID- 1038126
TI  - Existentialism: its relevance for practice and education.

PMID- 1038127
TI  - Evolution of a role: pediatric nurse clinician.

PMID- 1038128
TI  - Chauvinism: a two ways street.

PMID- 1038129
TI  - The battered administrator syndrome.

PMID- 1038130
TI  - What is an inservice instructor?

PMID- 1038131
TI  - RCN to withdraw from ICN?

PMID- 1038133
TI  - Editorial: Living in the real world.

PMID- 1038132
TI  - Law for the nurse supervisor. Refusal of blood transfusion.

PMID- 1038134
TI  - [Catheterization and bladder irrigation].

PMID- 1038135
TI  - [Health economics and systems analysis].

PMID- 1038136
TI  - [Federal efficiency planning. Personnel policies - employment policies].

PMID- 1038138
TI  - [Apropos the cause of nursing shortage].

PMID- 1038137
TI  - [St. Christopher's Hospice, London].

PMID- 1038139
TI  - [General guidlines for the use of anti-epileptica].

PMID- 1038140
TI  - [Editorial: The only responsibility].

PMID- 1038141
TI  - [The older person in social development].

PMID- 1038142
TI  - [Hospital and communication].

PMID- 1038143
TI  - [Not to enjoy, but to contribute of one's knowledge is the most important].

PMID- 1038145
TI  - [Nordland's administration opens a new nursing school].

PMID- 1038144
TI  - [Childbirth in transport; orientation of a study].

PMID- 1038146
TI  - [Smoking or not smoking in the hospital].

PMID- 1038147
TI  - [Death in the hospital].

PMID- 1038149
TI  - [What should nursing practice encompass?].

PMID- 1038148
TI  - [Children--abortion--responsibility].

PMID- 1038150
TI  - [What kind of basic education should Norwegian nurses have in the future?].

PMID- 1038151
TI  - [Feeding technics for dysphagic patients].

PMID- 1038152
TI  - [Data collection and professional ethics].

PMID- 1038153
TI  - [A nurse is special in her profession].

PMID- 1038154
TI  - [It can also be dead-calm in Loppa harbor city].

PMID- 1038155
TI  - [Celiac diseases in adults].

PMID- 1038156
TI  - [Accidental chemical compounds in various foods].

PMID- 1038157
TI  - [New interim provisions for official approval of basic nursing education].

PMID- 1038159
TI  - [Conversion of nursing philosophy into nursing practice].

PMID- 1038158
TI  - [Irritated and sensitive skin - dressing problems].

PMID- 1038160
TI  - [Administrative patient care plans].

PMID- 1038161
TI  - [An 11-hour working day with 5 hours travel time].

PMID- 1038162
TI  - [The terminally ill patient still active].

PMID- 1038163
TI  - Torure, imprisonment and suppression in Chile.

PMID- 1038164
TI  - [Pregnancy psychoses].

PMID- 1038165
TI  - [Nurses' dynamic field of action].

PMID- 1038166
TI  - [Masks and men].

PMID- 1038168
TI  - [Talk without end].

PMID- 1038167
TI  - [Headnurse in De gamles By: 86-year-olds lie attached to electrodes for weeks].

PMID- 1038169
TI  - [We shall remain together until a changed society].

PMID- 1038170
TI  - [New possibilities for nurses with the setting up of: cooperative committees in
      institutions, in counties and in communities].

PMID- 1038171
TI  - [Ultrasound studies in gynecology and obstetrics: the fetal heart can be
      monitored early in pregnancy].

PMID- 1038172
TI  - [Nursing research: for example, you can measure the effect of nursing care].

PMID- 1038173
TI  - [Group practice with a democratic form of management].

PMID- 1038175
TI  - [A futile waiting time].

PMID- 1038174
TI  - [In institutions are other things than wood which can burn: plastic constitutes a
      big and often overlooked fire hazard].

PMID- 1038176
TI  - [Nurses' first task in serving mankind: the nurse must take part in the fight
      against torture].

PMID- 1038177
TI  - [A real contribution to studies in nursing].

PMID- 1038178
TI  - [Amniocentesis and prenatal diagnosis: amniotic fluid gives information on fetal
      development].

PMID- 1038179
TI  - [A central person in primary health care].

PMID- 1038180
TI  - [Role and reality].

PMID- 1038181
TI  - [Nurses' responsibility for the necessary instructions to nurses' aides].

PMID- 1038182
TI  - [Study of the results of a complementary course].

PMID- 1038183
TI  - [A number of diseases owe their abnormalities to chromosomes: chromosome
      disorders can be prevented to a certain extent].

PMID- 1038184
TI  - [Research in nursing. 1: which methods should nurses follow in research
      studies?].

PMID- 1038185
TI  - [Still a valuable aid in decubitus prevention].

PMID- 1038186
TI  - [Food allergies].

PMID- 1038187
TI  - [Strict health requirements in Soviet working places: like this it is done in the
      Soviet - we struggle in vain].

PMID- 1038188
TI  - [Children's reactions to hospitalization: fear and nightmares].

PMID- 1038189
TI  - [Old Albert].

PMID- 1038190
TI  - [Income tax returns and deductions].

PMID- 1038191
TI  - [Luxury nurse becomes Vesterbro's own Mother Therese].

PMID- 1038192
TI  - [How do we nurses solve women's problems?].

PMID- 1038193
TI  - [Correct breathing is as important as the right food].

PMID- 1038194
TI  - [Recruitment of nursing students: many unemployed seek entry as a student nurse].

PMID- 1038195
TI  - [Nursing legislation for Latin America drafted by the (ICN) seminar].

PMID- 1038196
TI  - [Care plans can give continuity of care to patients: personnel should have
      confidence in care planning].

PMID- 1038197
TI  - [2 nurses like this on their way in research: researcher in science, this can
      expand the nurse's role].

PMID- 1038198
TI  - [It is clearly noticeable when a nursing secretary is missing].

PMID- 1038199
TI  - [Decubitex Akva makes lying in bed more comfortable].

PMID- 1038200
TI  - [Great developments in industrial nursing].

PMID- 1038201
TI  - [Poor nursing care].

PMID- 1038202
TI  - [Fire protection in nursing homes and other institutions: inmates' safety depends
      to a large degree upon the personnel].

PMID- 1038204
TI  - [All childbirths should be electronically monitored].

PMID- 1038203
TI  - [Nursing research: where does one make decisions about patient treatment?].

PMID- 1038205
TI  - [Danish tourist on his experiences in a Hungarian hospital: received apple tea
      and some dark handbroken bread].

PMID- 1038206
TI  - [This is how we train nursing assistants].

PMID- 1038207
TI  - [Nurses are frequently an arm extension for physicians].

PMID- 1038208
TI  - [Treatment of ovarian cancer: current treatment forms of ovarian cancer].

PMID- 1038209
TI  - [Nursing and being human].

PMID- 1038211
TI  - [The decisive factor in research is a critical attitude].

PMID- 1038210
TI  - [A hospital in Dacca where they never have enough of anything: nor have nurses
      milk for the children].

PMID- 1038212
TI  - [District nurses seek contact with first time gravidas].

PMID- 1038213
TI  - [Work in a casualty ward needs decision making].

PMID- 1038214
TI  - [Gynecologic nursing: understanding of both mental and physiological symptoms is
      important].

PMID- 1038215
TI  - [Flood catastrophe in Bangladesh: unparalleled aid action has saved ten
      thousands].

PMID- 1038216
TI  - [Is there any ground for fear in using p-pills: every sound and health woman can
      use p-pills].

PMID- 1038217
TI  - [Clarified personnel management improved following group discussion].

PMID- 1038219
TI  - [A crucial year].

PMID- 1038218
TI  - [The green light in obstetrics].

PMID- 1038220
TI  - [New year's reports on continued education ready].

PMID- 1038221
TI  - [Education for nurse instructors].

PMID- 1038222
TI  - [Staffing of nursing services].

PMID- 1038223
TI  - [Women, men and employment].

PMID- 1038224
TI  - [Departmental leadership functions. A mapping of the job situation of department
      managers].

PMID- 1038225
TI  - [Infant died of ileus. Complaints about the organization of free care in the
      hospital].

PMID- 1038226
TI  - [Will 70 or 100 percent get continued education?].

PMID- 1038227
TI  - [Studies in the patient care field].

PMID- 1038228
TI  - [Democracy in the place of employment?].

PMID- 1038229
TI  - [Observations on pacemakers].

PMID- 1038231
TI  - [Team care should not just be an end but also a means].

PMID- 1038230
TI  - [Nurse in a mountain world].

PMID- 1038232
TI  - [Gerd Zetterstrom will study care of the dying].

PMID- 1038233
TI  - [We need research in administration].

PMID- 1038234
TI  - [New medication system for the hospital].

PMID- 1038235
TI  - [In case of conflict].

PMID- 1038236
TI  - [The long struggle for authorization ends].

PMID- 1038237
TI  - [Transplantation and hospital autopsy].

PMID- 1038238
TI  - [Nurses can do vaccinations after additional training].

PMID- 1038239
TI  - [Psychotherapy or psychopharmaceutical agents? Discussion on the treatment of
      schizophrenia].

PMID- 1038240
TI  - [Radda Barnen (Save-a-Child) in a campaign for the child in hospital].

PMID- 1038241
TI  - [Analysis of Article 32 gives power to employees].

PMID- 1038242
TI  - [Nurse in a Greenland village].

PMID- 1038244
TI  - [Social welfare's end and means].

PMID- 1038243
TI  - [Continued education in psychiatry].

PMID- 1038245
TI  - [Nurses prepared for conflict].

PMID- 1038246
TI  - [Women's year: right to be human- an exhibit on sex roles].

PMID- 1038247
TI  - [Proposal to the government on measures against sex discrimination].

PMID- 1038248
TI  - [Ureter surgery of the wrong side].

PMID- 1038249
TI  - [Federal budget: an additional 500 students accepted for basic education].

PMID- 1038250
TI  - [Excellence in infant care].

PMID- 1038251
TI  - [The unsolved equation?].

PMID- 1038252
TI  - [Mental stress increased in working life].

PMID- 1038253
TI  - [3 opinions on psychiatric treatment methods].

PMID- 1038254
TI  - [Courses in aid and disaster services give a good foundation for working in
      developing countries].

PMID- 1038255
TI  - [Sudden infant death].

PMID- 1038256
TI  - [Eyedrops, applying eye ointment, applying eye bandages, eye irrigation].

PMID- 1038257
TI  - [Possiblities of mass media in nursing education].

PMID- 1038258
TI  - [Effective communication].

PMID- 1038259
TI  - [The child in the surgical unit].

PMID- 1038260
TI  - [Blood analysis].

PMID- 1038261
TI  - [14 days of health care in Mao-tse-tungs country. Impressions of a trip in the
      People's Republic of China, from July 15-29, 1974].

PMID- 1038263
TI  - [Nursing audit].

PMID- 1038262
TI  - [The quality of nursing care is not guaranteed by a stamp of approval].

PMID- 1038264
TI  - [Observations on quality of nursing care].

PMID- 1038265
TI  - [Reporting and recording of data].

PMID- 1038266
TI  - [Eyedrops, applying eye ointment, applying eye bandages, eye irrigation. II].

PMID- 1038267
TI  - [Sleep and sedatives. I].

PMID- 1038268
TI  - [Children with tics].

PMID- 1038269
TI  - [Disposables; objections on principle].

PMID- 1038270
TI  - [Information from the clinical chemical laboratory. Hematologic laboratory].

PMID- 1038271
TI  - [Can medication influence the reliability of the "pill"?].

PMID- 1038272
TI  - [Stimulating neighborhood health centers].

PMID- 1038273
TI  - [Neck injuries].

PMID- 1038274
TI  - [Relationships in the institutional care of mentally retarded].

PMID- 1038275
TI  - [Relationship between parents and their institutionalized mentally handicapped
      children].

PMID- 1038276
TI  - [Can we still speak of nursing in the care for mentally retarded?].

PMID- 1038277
TI  - [Care for mentally retarded, Outline of a structure; regionalization].

PMID- 1038278
TI  - [Team nursing and team nursing. An organizational analysis and classification].

PMID- 1038279
TI  - [Sleep and sedatives. II].

PMID- 1038280
TI  - [A unique form of higher nursing education: Ecole Internationale d'Enseignement
      Superiour].

PMID- 1038281
TI  - [Diagnosis of heart infarct and determination of infarct size using serum enzyme
      levels].

PMID- 1038282
TI  - [Interview with dialysis patients].

PMID- 1038283
TI  - [Patient's opinion about their care received in the Diaconesseshuis in Leiden.
      Example of a patient inquiry].

PMID- 1038284
TI  - [A suggestion at the time of admission of a child to a hospital].

PMID- 1038285
TI  - [Safety for children].

PMID- 1038286
TI  - [Euthanasia and reality].

PMID- 1038287
TI  - [Information from the clinical chemical laboratory. Erythrocyte sedimentation
      rate].

PMID- 1038288
TI  - [Care in small hospitals or how small can a hospital be?].

PMID- 1038289
TI  - [Conversation about: examen nursing care A].

PMID- 1038290
TI  - [Dehydration in infants].

PMID- 1038291
TI  - [Team nursing. I. Team nursing, solution for what?].

PMID- 1038292
TI  - [Electric safety of patients in hospitals].

PMID- 1038293
TI  - [Rights and duties of participants in staff and faculty courses].

PMID- 1038294
TI  - [The influencing of blood coagulation].

PMID- 1038295
TI  - [Quality of nursing care].

PMID- 1038296
TI  - [Medical Chief Inspection of Public Health. Amplification of regulations for
      Diploma A nursing education].

PMID- 1038297
TI  - Letters to the editor: The use of demorol as an anesthetic agent.

PMID- 1038298
TI  - Narcotic anesthesia for cardiovascular surgery.

PMID- 1038299
TI  - Anatomy and physiology of the kidney.

PMID- 1038300
TI  - Editorial: Accreditation for schools/programs for nurse anesthetists.

PMID- 1038301
TI  - Surgical economics.

PMID- 1038303
TI  - The fine line of patient consent.

PMID- 1038302
TI  - An anesthetic consideration for cesarean section.

PMID- 1038304
TI  - Programmed instruction.  Patient assessment: examination of the ear.

PMID- 1038305
TI  - Editorial: Health care in prison: an anachronism?

PMID- 1038306
TI  - The development of intense positive countertransference feelings in the therapist
      toward a patient.

PMID- 1038307
TI  - "Yes, I hear you, Mr. H.".

PMID- 1038308
TI  - The blind mother.

PMID- 1038309
TI  - Health care in prison: a view from inside.

PMID- 1038310
TI  - Health care in prison: change in one city's system.  It started with a director
      of nursing.

PMID- 1038311
TI  - Health care in prison: change in one city's system.  Leadership at the cell-block
      level.

PMID- 1038312
TI  - Health care in prison: change in one city's system.  Mental health nursing of
      inmates.

PMID- 1038313
TI  - Health care in prison: change in one city's system.  Replacing pill pushing with
      nursing.

PMID- 1038314
TI  - Screening for Tay-Sachs disease.

PMID- 1038315
TI  - A nurse fights corruption.

PMID- 1038316
TI  - Chronicity: a key to learning.

PMID- 1038317
TI  - Indwelling catheters.

PMID- 1038318
TI  - How OSHA affects hospitals and nursing homes.

PMID- 1038319
TI  - Correcting inverted nipples--an aid to breast feeding.

PMID- 1038320
TI  - Breast-feeding classes on the postpartum unit.

PMID- 1038321
TI  - What income tax decuctions can you take as a nurse?

PMID- 1038322
TI  - Endocrine influences on pulmonary maturation and the lecithin/sphingomyelin ratio
      in the fetal baboon.
AB  - By utilizing the baboon model system, preliminary data indicate that intra
      amniotic dexamethasone caused an increase in the L/S ratio. Metopirone 11
      betahydroxylase inhibition prevented the expected increase in the L/S ratio
      without influencing pulmonary distensibility, stability on deflation, or lung
      mince minimal surface tension. Infants born at term to Metopirone-treated baboons
      were free of pulmonary distress and survived to adolescence.

PMID- 1038323
TI  - Editorial: Supervisory nurses caught in increasing tensions.

PMID- 1038324
TI  - Leaders influence, guide nursing by specific action.

PMID- 1038325
TI  - Communication to PRR nurses means better care.

PMID- 1038326
TI  - Housekeeping in operating suites.

PMID- 1038327
TI  - An anesthesiologist looks at OR design.

PMID- 1038328
TI  - Morocco; an exotic land.

PMID- 1038329
TI  - Editorial: Study proves OR nurses' purchasing power.

PMID- 1038330
TI  - Joint Council for allied health accreditation.

PMID- 1038331
TI  - OR staff nurse underestimated as educator.

PMID- 1038333
TI  - Without foundation, one does not become specialist.

PMID- 1038332
TI  - Federation supports AANA; rejects self-study.

PMID- 1038334
TI  - Unit nurses less apathetic if aware of OR procedures.

PMID- 1038335
TI  - Representative experiences sufficient for students.

PMID- 1038336
TI  - Future of OR curricula: generalist preparation, further specialization.

PMID- 1038337
TI  - Malignant hyperpyrexia: anesthesia complication.

PMID- 1038338
TI  - Management of pulmonary edema.

PMID- 1038339
TI  - Zoo surgery challenges clinicians.

PMID- 1038340
TI  - Misuse of masks reduces effectiveness.

PMID- 1038342
TI  - Cancer complicated in growth, treatment.

PMID- 1038341
TI  - Indwelling catheter nursing care.

PMID- 1038343
TI  - Waste disposal system.

PMID- 1038344
TI  - [The nurse sister today].

PMID- 1038345
TI  - [Does the patient have a right to his beliefs? His belief, not mine].

PMID- 1038346
TI  - [His beliefs...not yours].

PMID- 1038347
TI  - [Towards a thoroughly humane policy of peoples' health].

PMID- 1038348
TI  - [C.I.C.I.A.M.S. (Catholic International Committee of Nurses and Medico-social
      aides); its history, its objectives, its structure].

PMID- 1038349
TI  - [Nurses...independent].

PMID- 1038350
TI  - The Nurse Practice Act.

PMID- 1038351
TI  - The pharmacology and clinical use of digitalis.

PMID- 1038352
TI  - Rehabilitation after stroke.

PMID- 1038353
TI  - [Histoplasmosis].

PMID- 1038355
TI  - [Prevention of frostbite, and care in these affections].

PMID- 1038354
TI  - [Epidemiology and prevention of smallpox and epidemic parotitis].

PMID- 1038356
TI  - [Standard ways of immobilization during transport].

PMID- 1038357
TI  - [Gonorrhea in women].

PMID- 1038358
TI  - [Nocturnal enuresis in children].

PMID- 1038360
TI  - [Rib fractures and their treatment].

PMID- 1038359
TI  - [Disorders of the internal organs in chronic alcoholism].

PMID- 1038361
TI  - [Hygiene for a woman following surgical abortion].

PMID- 1038362
TI  - [Surgery of the lymphatic system].

PMID- 1038363
TI  - [Experience in the activities of a feldsher council of the regional health
      epidemiology services].

PMID- 1038364
TI  - [Communistic upbringing of youth].

PMID- 1038365
TI  - [Organization of health inspection controls on food additives].

PMID- 1038366
TI  - [Problems in vocational training in medical schools].

PMID- 1038367
TI  - [Problems of organization of medico-sanitation services for builders of the
      Baikal-Amur railway].

PMID- 1038368
TI  - [Anthrax; preventive measures].

PMID- 1038369
TI  - [Acute respiratory diseases and influenza at the new works building site].

PMID- 1038371
TI  - [Anal fissures].

PMID- 1038370
TI  - [Thermal burns and their treatment principles].

PMID- 1038372
TI  - [Management of pregnancy and labor in women with a uterine scar].

PMID- 1038373
TI  - [Editorial: A new stage in the preparation of paramedical and pharmaceutical
      personnel].

PMID- 1038374
TI  - [Acceleration].

PMID- 1038375
TI  - [Diagnosis and first aid in tendon injuries of the fingers].

PMID- 1038376
TI  - [Health education for control of trichophytosis and foot mycoses].

PMID- 1038377
TI  - [Experience in rodent control in a residential district].

PMID- 1038379
TI  - [The body's defenses].

PMID- 1038378
TI  - [A method of calculation and analysis of perinatal mortality].

PMID- 1038380
TI  - [Management of health services].

PMID- 1038381
TI  - [The humanization of hospitals].

PMID- 1038382
TI  - [Technical aspects of nursing].

PMID- 1038383
TI  - [Helicopter assistance].

PMID- 1038384
TI  - [Report about nuclear medicine from the radioisotope department of the Brugmann
      Hospital, in Brussels. Brain studies using radioisotopes].

PMID- 1038385
TI  - Focus on National Health Insurance.

PMID- 1038386
TI  - The nurse practitioner.

PMID- 1038387
TI  - Breakthrough: a year in retrospect.

PMID- 1038388
TI  - I believe ... nursing as a profession and you.

PMID- 1038389
TI  - Should PN/VN students be members of NSNA?

PMID- 1038390
TI  - Why student rights?

PMID- 1038391
TI  - NSNA adopts guidelines for grievance procedures.

PMID- 1038392
TI  - [Hygiene: the plague].

PMID- 1038393
TI  - [Diagnosis of diarrhea].

PMID- 1038394
TI  - [Mitral stenosis].

PMID- 1038395
TI  - [Multiple sclerosis and current research].

PMID- 1038396
TI  - [Male sterility].

PMID- 1038397
TI  - [Biermer's anemia (symptoms - diagnosis - treatment)].

PMID- 1038398
TI  - [Yellow fever].

PMID- 1038399
TI  - [Diagnosis of icterus in adults].

PMID- 1038400
TI  - [Villous colorectal tumors].

PMID- 1038401
TI  - [Natural contraceptive methods].

PMID- 1038402
TI  - [Headache].

PMID- 1038403
TI  - [Salary, primary factor in job satisfaction].

PMID- 1038404
TI  - [Criteria for quality health education].

PMID- 1038405
TI  - [The future of the Foundation of Canadian Nurses depends upon its members].

PMID- 1038406
TI  - [When the consumers of care speak].

PMID- 1038407
TI  - [Testimony of 3 nurses].

PMID- 1038408
TI  - [The relief of pain before delivery].

PMID- 1038409
TI  - [Community health nursing: what nurses from Quebec think about it].

PMID- 1038410
TI  - [Too much or too little use of nurses in physicians' offices?].

PMID- 1038411
TI  - [The nurses of Brochet].

PMID- 1038412
TI  - [Cystic fibrosis].

PMID- 1038413
TI  - [At the administrative council of the CNA, 20th and 21st of February, 1975:
      obtaining evaluation standards of nursing practice].

PMID- 1038414
TI  - [Is there a way to help man?].

PMID- 1038415
TI  - [Homecare services unique in their orientation].

PMID- 1038416
TI  - [The hyperactive child].

PMID- 1038417
TI  - [Communication problems].

PMID- 1038419
TI  - Mother and baby services in Toronto and New York City.

PMID- 1038418
TI  - [Accreditation of health facilities].

PMID- 1038420
TI  - The treatment of nocturnal enuresis by bell and pad in general practice.

PMID- 1038421
TI  - Are babies more difficult to screen for hearing?

PMID- 1038422
TI  - Child health and education in the seventies. A national study in England,
      Scotland and Wales of all children born 5th-11th April 1970.

PMID- 1038423
TI  - Management of gastroenteritis at home.

PMID- 1038424
TI  - The health visitor and the isolated mother.

PMID- 1038425
TI  - Why sociology?

PMID- 1038426
TI  - [Diseases transmitted by sexual contact: failure for public health].

PMID- 1038427
TI  - [Hyperlipidemias: present-day diseases].

PMID- 1038428
TI  - [Hygiene: typhus].

PMID- 1038429
TI  - [Hygiene: 6th period of nurses' study program. Epidemiological problems and large
      endemics].

PMID- 1038430
TI  - [Icterus of the newborn infant].

PMID- 1038431
TI  - [Primary cancer of the liver].

PMID- 1038432
TI  - Trends in accreditation.

PMID- 1038434
TI  - Opening the hospital inservice classroom.

PMID- 1038433
TI  - Patterns of preference: nurses view continuing education.

PMID- 1038435
TI  - Orientation--first impressions last.

PMID- 1038436
TI  - What do you develop in personnel development?

PMID- 1038437
TI  - [Syringes and needles].

PMID- 1038438
TI  - Educators as change agents in the institution of nursing; using GSA (guided self
      analysis) as the enabler.

PMID- 1038439
TI  - Continuing education--why?

PMID- 1038440
TI  - Landmark statement. Importance of voluntary national accreditation to nursing
      education.

PMID- 1038441
TI  - Inservice education copes with resistance to change.

PMID- 1038442
TI  - Nursing inservice education in rural America: one proposal for meeting the need.

PMID- 1038444
TI  - "Do it yourself" programs.

PMID- 1038443
TI  - An editorial exploration: Health education, an institutional responsibility.

PMID- 1038445
TI  - Learning human relations technologies through continuing education in health care
      professions.

PMID- 1038446
TI  - Philosophical concerns and issues in continuing education.

PMID- 1038448
TI  - Editorial: NAPNES leaders learn, share, guide.

PMID- 1038447
TI  - Professional education and its implication for continuing education.

PMID- 1038450
TI  - Cardiac pacemakers.

PMID- 1038449
TI  - Iron deficiency: a problem of prevention.

PMID- 1038451
TI  - Drug therapy and the homebound cardiac patient.

PMID- 1038452
TI  - A uniform forecast: uniformity is on the outs.

PMID- 1038453
TI  - Mainline to mainstream: the life of an ex-addict.

PMID- 1038454
TI  - Effects of death on the living.

PMID- 1038455
TI  - Anorexia nervosa.

PMID- 1038457
TI  - Their home we share.

PMID- 1038456
TI  - Please reach out to me, your elderly person.

PMID- 1038458
TI  - Pharmacodynamic nursing.

PMID- 1038459
TI  - Hup, two, three, four. U.S. Army licensed practical nurses.

PMID- 1038461
TI  - How to do the most for your mastectomy patient.

PMID- 1038460
TI  - Oral health counseling.

PMID- 1038462
TI  - Cancer of the colon and rectum: cure or crisis? I.

PMID- 1038463
TI  - The art of being in charge.

PMID- 1038464
TI  - Emergency care of the unconscious patient.

PMID- 1038466
TI  - Wishing for words.

PMID- 1038465
TI  - Collective bargaining: what's it all about and what can it do for you. 1.

PMID- 1038467
TI  - Editorial: Right to treatment.

PMID- 1038468
TI  - The therapeutic community; all relationships relevant.

PMID- 1038469
TI  - Cancer of the colon and rectum: cure or crisis? II.

PMID- 1038471
TI  - Collective bargaining. What's it all about and what can it do for you? 2.

PMID- 1038470
TI  - Aftermath of stroke: triumph or tragedy?

PMID- 1038472
TI  - Industrial nursing; a new LP/VN frontier.

PMID- 1038473
TI  - Educational needs expressed by health related educators.

PMID- 1038474
TI  - I'm a nurse too.

PMID- 1038475
TI  - [Physiological mechanism of edema - classification and physiopathology of edema].

PMID- 1038476
TI  - [Nursing of terminal cancer patients with edema].

PMID- 1038477
TI  - [Treatment of edema and diuretics - advantages and disadvantages of diuretics].

PMID- 1038478
TI  - [Diet therapy of edema].

PMID- 1038479
TI  - [Human morphology and somatotypes. 7].

PMID- 1038480
TI  - [Introduction of the problem oriented system and team care].

PMID- 1038481
TI  - [Education and training - on the theory of the goal of nursing education].

PMID- 1038482
TI  - [Edema and medical history taking - examinations based on patient's complaints
      and diagnostic methods].

PMID- 1038484
TI  - [Edema and liver diseases].

PMID- 1038483
TI  - [Edema and renal diseases].

PMID- 1038485
TI  - [Edema and cardiac diseases].

PMID- 1038486
TI  - [Idiopathic edema].

PMID- 1038487
TI  - [Nursing of a child with nephrogenic edema - A case with marked edema due to
      nephrotic syndrome].

PMID- 1038489
TI  - [Nursing of a patient with cardiogenic edema].

PMID- 1038488
TI  - [Nursing of a patient with hepatogenic edema and ascites].

PMID- 1038490
TI  - [Nursing of patients with edema due to burns].

PMID- 1038491
TI  - [Reflexions on the state of nursing education: on the status of nursing students
      in the practical nursing course].

PMID- 1038492
TI  - [Re-evaluation of educational methods. (1). Teaching methods to develop
      individual potentials].

PMID- 1038493
TI  - [School finance and the purpose of establishing a nursing school: the outline of
      school finance and a study of the expense of nursing schools].

PMID- 1038494
TI  - [Various problems of nursing and formulation of nursing theories: the theory of
      social interaction in nursing].

PMID- 1038495
TI  - [Continuing education in nursing. (1). A study of continuing education; an
      observation on nurses attending universities while actively engaged in the
      nursing profession].

PMID- 1038496
TI  - [Observation of activities of nursing instructors at the staff room of a nursing
      school].

PMID- 1038497
TI  - [Theories and methodology of human development. 4. Human development and guidance
      of students. (2)].

PMID- 1038498
TI  - [My theory of nursing education. 1. Qualifications for the nursing instructor].

PMID- 1038499
TI  - [Education of the working class. (2)].

PMID- 1038500
TI  - Concerns of an obstetric patient experiencing long-term hospitalization.

PMID- 1038501
TI  - Diaphragm effectiveness depends largely on you: patients practice what you teach.
      Preventing the "diaphragm byby syndrome": a matter of technique, teaching, and
      time.

PMID- 1038502
TI  - Diaphragm of effectiveness depends largely on you: patients practice what you
      teach. Why some won't try the diaphragm method - why others try and fail.

PMID- 1038503
TI  - The clinical specialist--link between theory and practice.

PMID- 1038504
TI  - Portrait of a female.

PMID- 1038506
TI  - [Mother's milk and breast feeding].

PMID- 1038505
TI  - Helping the mother solve problems with feeding her infant.

PMID- 1038507
TI  - [Does vitamin C prevent arteriosclerosis?].

PMID- 1038508
TI  - [Editorial: Towards a brighter future].

PMID- 1038509
TI  - [The danger of threatened miscarriage and steps to be taken].

PMID- 1038510
TI  - [Editorial: Central Administrative Board should have through knowledge of
      maternity care].

PMID- 1038511
TI  - [Working hours utilization by midwives at health centers].

PMID- 1038512
TI  - [Training and role of the midwife object of study performed by Council of
      Europe].

PMID- 1038513
TI  - [Psychological development of children and formation of eating habits].

PMID- 1038515
TI  - [Importance of the Apgar score].

PMID- 1038514
TI  - [Anxiety in certain mental disorders].

PMID- 1038516
TI  - [The birth of the family].

PMID- 1038517
TI  - [Features of maternity care in Norway].

PMID- 1038519
TI  - [Medical countermeasures for remote regions as reflected from the nurses'
      viewpoint].

PMID- 1038518
TI  - [Inspecting our government's medical policies - nurses' viewpoint of its
      policies].

PMID- 1038520
TI  - [Returning to the starting point of the establishment of the association. The
      idea of integrated nursing and the pursuit of its practice].

PMID- 1038521
TI  - [The meaning of nursing - personal learning from nursing in Denmark].

PMID- 1038523
TI  - [Nurses around the world: Great Britain - Republic of Kenya].

PMID- 1038522
TI  - [From nursing education in the United States].

PMID- 1038524
TI  - [Adverse reactions of drugs. 8. Adverse reactions of sex hormones].

PMID- 1038525
TI  - [Death in nursing. 11. Very soon now, won't it?].

PMID- 1038526
TI  - [Nursing in cardiac diseases. 18. Heart catheterization test].

PMID- 1038527
TI  - [Nursing in specialties--having finished a research study in Los Angelos].

PMID- 1038528
TI  - [Summarized report of the Nursing Education Problems Study meeting. 1].

PMID- 1038529
TI  - [First aid in ear injuries].

PMID- 1038530
TI  - [Sudden changes in the eye in general diseases].

PMID- 1038531
TI  - [Application of ultrasound in the treatment of eye diseases].

PMID- 1038532
TI  - [Pharyngitis].

PMID- 1038533
TI  - [Parodontal disease].

PMID- 1038534
TI  - [Various diseases of the organs of the abdominal cavity].

PMID- 1038535
TI  - [Prevention of diabetes mellitus in the elderly].

PMID- 1038536
TI  - [Hydrocortisone phonophoresis in trauma and diseases of the locomotor system in
      athletes].

PMID- 1038537
TI  - [Prevention and treatment of osteo-ligamentous diseases of the hand].

PMID- 1038538
TI  - [Psychotherapy of patients with neglected forms of carcinoma].

PMID- 1038539
TI  - [Experience in the nurse's role in the medical procedures room in a hospital].

PMID- 1038540
TI  - [Experience in admission room activities of a factory medical center].

PMID- 1038542
TI  - [Use of a special stand and of the directions card in obtaining blood samples
      from patients].

PMID- 1038541
TI  - [A finger dressing].

PMID- 1038543
TI  - [Neuritis of the auditory nerve].

PMID- 1038544
TI  - [Preoperative examination of the patient with dento-maxillary deformities].

PMID- 1038545
TI  - [Treatment of infectious nonspecific polyarthritis with ultrasound, in
      combination with medicinal preparations].

PMID- 1038547
TI  - [Ultraviolet rays--a potent factor in disease prevention].

PMID- 1038546
TI  - [Acupuncture].

PMID- 1038548
TI  - [Time factors in oral administration of medicines].

PMID- 1038549
TI  - [Functions of a preliminary reception room (before the physicians' examination)].

PMID- 1038550
TI  - [Organization of activities in the ophthalmology room of a polyclinic].

PMID- 1038551
TI  - [Organization of activities in the vaccination room at the rural medical
      district].

PMID- 1038552
TI  - [Prevention and treatment of hypertensive diseases].

PMID- 1038553
TI  - [Methods of training senior nurses].

PMID- 1038554
TI  - [Increasing the effectiveness of preventive activities of shop nurses].

PMID- 1038555
TI  - [Vocational training of nurses in a rural region].

PMID- 1038556
TI  - [Work planning with paramedical personnel of a hospital].

PMID- 1038557
TI  - [Helicopters for emergency medical aid].

PMID- 1038558
TI  - [Acute renal insufficiency in children].

PMID- 1038559
TI  - Infant feeding and the health educator.

PMID- 1038560
TI  - Time to listen.

PMID- 1038561
TI  - The educational welfare officer.

PMID- 1038562
TI  - Ethical dilemmas in obstetric and newborn care.

PMID- 1038563
TI  - Editorial: Bed and breakfast.

PMID- 1038564
TI  - The midwife and puerperal psychosis.

PMID- 1038565
TI  - Economic and environmental aspects of family planning.

PMID- 1038566
TI  - The story of Graham.

PMID- 1038567
TI  - Editorial: Antenatal assessment and education.

PMID- 1038568
TI  - The community care option--a survey of one year's experience in 10 centres.

PMID- 1038569
TI  - The use of prostaglandins in the induction of labour.

PMID- 1038570
TI  - The fourth trimester?

PMID- 1038571
TI  - Drugs affecting the upper respiratory tract.

PMID- 1038572
TI  - Guidelines for teachers of parentcraft and relaxation. Session I: shopping for
      baby and you.

PMID- 1038573
TI  - Intimate duties of the midwife.

PMID- 1038574
TI  - An "open" opportunity.

PMID- 1038575
TI  - The midwife teachers diploma; marriage of a profession and a university.

PMID- 1038577
TI  - The midwife in Northern Ireland.

PMID- 1038576
TI  - Teachers' page. 8. Practical instructors course for teaching midwives.

PMID- 1038578
TI  - "Nurse....forget the outside world".

PMID- 1038579
TI  - "Black spot" - an exercise in the prevention of mental retardation.

PMID- 1038580
TI  - Guidelines for teachers of parentcraft and relaxation. Session 2: health in
      pregnancy.

PMID- 1038581
TI  - A student's view of the Open University.

PMID- 1038582
TI  - Teachers' page. 9. University involvement in midwifery education.

PMID- 1038584
TI  - The midwifery profession in France.

PMID- 1038583
TI  - Guidelines for teachers of parentcraft and relaxation. Session 3: conception and
      development.

PMID- 1038585
TI  - The proposed Children Bill.

PMID- 1038586
TI  - Statutory qualification?

PMID- 1038587
TI  - Functions of an occupational health service.

PMID- 1038588
TI  - Design for machinery safety.

PMID- 1038589
TI  - OH in Europe--1. The UK.

PMID- 1038590
TI  - OH in Europe--3. Germany.

PMID- 1038591
TI  - Electrical injuries.

PMID- 1038592
TI  - Accident investigation systems.

PMID- 1038593
TI  - Acute acetone intoxication.

PMID- 1038594
TI  - Calling all women.

PMID- 1038595
TI  - Editorial: The nursing process.

PMID- 1038596
TI  - The orthopedic nursing diagnosis.

PMID- 1038597
TI  - Wound infection and gas gangrene.

PMID- 1038598
TI  - Behavioral objectives for orthopedic nursing personnel. Part I.

PMID- 1038599
TI  - A vast nation's quest for a 'new medicine'.

PMID- 1038600
TI  - Recognition and management of life threatening emergencies.

PMID- 1038601
TI  - Faculty-curriculum development. Part III. Conceptual framework - its meaning and
      function.

PMID- 1038602
TI  - The meaning and functions of concepts and theories within education and nursing.

PMID- 1038603
TI  - Today's conceptual frameworks within baccalaureate nursing programs.

PMID- 1038604
TI  - The conceptual framework and its influence on learning experiences.

PMID- 1038605
TI  - The conceptual framework as part of the curriculum process.

PMID- 1038606
TI  - Educational trends which influenced the development of the conceptual framework
      within the curriculum.

PMID- 1038607
TI  - The media center: in planning the center...

PMID- 1038608
TI  - Editorial: Nurse practitioner: the way to go?

PMID- 1038609
TI  - Assessing the quality of care.

PMID- 1038610
TI  - Psychological characteristics of the nurse practitioner.
AB  - First, present research on the selection and characteristics of practitioners is
      both controversial and important. We need good answers to be helpful to those
      planning directions for the future of nursing. Second, we need good descriptive
      research indicating how applicants for different types of programs vary; how age,
      experience, and background factors affect the outcome of training. Third, we need
      multi-criteria for measuring success and effectiveness-criteria that will take
      into account both competence and commitment and will measure competence in a
      variety of ways. Fourth, we need more theory for what we are measuring and why we
      are measuring it. We need predictions from different personality and
      developmental theories. We need to contrast and combine these theoretical
      approaches, and we need more complex variables than we currently have. We need
      constructs and types rather than simple empiricism and single traits. Finally, we
      should not overlook the fact that the majority of nurse practitioners are women,
      and thus we are doing research on an interesting group at a significant time in
      women's history. If we are alert and responsive to what we learn about our
      subjects, we may also gain a deeper understanding of the lives of adult women and
      how they are affected by social change and changing times.

PMID- 1038611
TI  - Expectation vs realization in the nurse practitioner role.

PMID- 1038612
TI  - Nurse practitioner research: some neglected issues.

PMID- 1038613
TI  - Nurse practitioner: a model for evaluation?

PMID- 1038614
TI  - Effect of timed hygienic measures on oral mucosa in a group of elderly subjects.
AB  - A study was conducted to identify and compare the effect produced on oral mucosa
      by the application of oral hygiene by the use of either a toothette or a
      toothbrush at two-, three-, or four-hour intervals during an eight-hour period
      for ten days. The sample consisted of 48 geriatric patients randomly selected
      from an extended care facility. Two investigators were responsible for scoring
      nine dependent variables--salivation, tongue moisture, tongue color, moisture of
      palates, color of gingiva, condition of membranes, lip texture, lip moisture, and
      soft tooth debris-- twice daily. Data were analyzed using multiple regression
      analysis. Results of the study indicated significant improvement in six dependent
      variables in the four-hour interval groups. In the two-hour interval groups, two
      dependent variables were improved significantly. The toothbrush was more
      effective in stimulating gingival tissue and removing soft tooth debris; the
      toothette was found to be more effective in producing improvement in other oral
      tissues.

PMID- 1038615
TI  - Perception of life change events by the elderly.
AB  - The perception of the amount of adjustment necessitated by the occurrence of
      common life events was assessed for 41 members of a senior citizens' club who
      ranged in age from 65 to 84. Significant agreement was found between the elderly
      subjects and the normative sample with regard to rank ordering of the life
      events. Markedly significant differences were found between the elderly and the
      normative sample in the magnitudes assigned to the life events, with the elderly
      group assigning the larger magnitude to most items.

PMID- 1038616
TI  - Needs of the grieving spouse in a hospital setting.
AB  - In an attempt to determine whether the spouse whose mate is terminally ill or had
      died can recognize his own needs and whether he, himself, perceives that he has
      been helped by nurses, 27 spouses were interviewed during the terminal illness of
      their mates. Subsequently, 18 mates died; 14 of the spouses were interviewed
      after the death event. Data were collected by means of tape-recorded
      semistructured interviews, with the exception of one written second interview.
      Eight needs of grieving spouses were noted. Twenty-five spouses identified all
      eight needs and the other two spouses identified five and seven needs,
      respectively. The fact that the needs were identified did not mean, however, that
      these needs had been met. Spouses believed nurses had been helpful to the dying
      mates. The spouses recognized that the nurses' primary responsibility was to the
      patients and felt that nurses were too busy to help the families. The death event
      did not alter the identified needs and concerns of the spouses. Eighty-seven
      percent of the needs identified in the second interview had been identified in
      the first interview.

PMID- 1038617
TI  - The meaning of mental health: a report of two ethnoscientific studies.
AB  - The use of the ethnoscientific method in nursing research is demonstrated in an
      initial study and a replication of that study, utilizing male and female
      informants. The domain of "mental health" was explored, analyzed, and contrasted
      within the subculture of the central city resident and the subculture of the
      psychiatric-mental health professional. To facilitate an understanding of
      ethnoscience, the method is briefly outlined; then, to illustrate the
      methodology, data from one informat are presented in depth. A summary of the
      major similarities and contrasts that emerged from the data of both studies is
      presented. Implications for nursing of the research and ethnoscience are
      discussed.

PMID- 1038618
TI  - Increasing the quality of patient care through performance counseling and written
      goal setting.
AB  - Patient care scores of staff nurses in seven Veterans Administration hospitals
      who used a performance counseling protocol that required written goal setting,
      coupled with head nurse modeling and support to achieve goals (experimental),
      were compared with scores of nurses who continued with usual practice (control).
      Staff nurses chose their own goals. One goal was to improve patient care and the
      other was to improve staff nurse professional competence. After six months,
      experimental group scores were higher on five patient care scales, one
      significantly. After 12 months, scores shifted in favor of the control group, one
      significantly. Experimental group scores were higher on patient interview
      questions after six months and made additional gains after 12 months.
      Experimental nurses generally were more satisfied with their nursing careers and
      described working relationships more positively. Some progress the experimental
      nurses made after six months was lost after 12 months. Nurses who received high
      patient care scores from outside observers described the hospital working
      environment in more positive terms. Relationships of three instruments that
      measure quality of patient care are presented.

PMID- 1038619
TI  - Editorial: A serious omission.

PMID- 1038620
TI  - 8-4 Research. Part 1: a stance for nursing research--tenacity or inquiry.
AB  - In a two-part series, a/proprosal is presented for implementation research which
      integrates practical, technical, and political judgment. This implementation
      research--or 8-4 research--is contrasted with pseudo-technical research. In Part
      I it is proposed that nursing research should be assessed in terms of payoff for
      nursing rather than promise for nursing, that 8-j research is a suitable paradigm
      for all nursing research, and that nursing research is a suitable preoccupation
      for any and all nursing personnel. Part II (to appear in the May-June 1975
      Nursing Research) develops eight points of encounter--as between 8-4 research and
      pseudotechnical research--pertinent to designing nursing research. A conception
      of design is proposed that displays an appropriate role for conation, drive, or
      intent in any designed research.

PMID- 1038621
TI  - Application of selected nursing research findings into nursing practice: a pilot
      study.
AB  - This study investigated the extent to which one research finding, obtained
      through a series of investigations and reported widely in the nursing literature,
      was being utilized by nurse practitioners for the improvement of nursing
      practice. Based on the research findings of Nichols and colleagues on the oral
      mode of temperature determination, a questionnaire was constructed and
      administered to 87 registered nurses in the states of Massachusetts and New York.
      Only one response corresponded to the findings of Nichols and colleagues on how
      oral temperature is correctly determined. Contradictions between theory and
      practice, moreover, were cited.

PMID- 1038622
TI  - Changes in judgment of duration with different patterns of auditory information
      for individuals confined to bed.
AB  - A theoretical proposition that changes in the organization and structure of
      auditory information result in changes in temporal experience was tested in this
      study. Changes were measured in the judgment of duration of a 40-second interval
      that occurred in three different patterns of auditory information among
      individuals confined to bed. The sample consisted of 90 men and 90 women aged 18
      to 35 years who had no known physical or mental health problems. Subjects rested
      in bed in a comfortable room for two and one-half hours. Each subject received
      one of three forms of auditory information-called decoded, coded, and ambient
      auditory information. At four periods during the 150 minutes of auditory
      information (25 minutes, 75 minutes, 120 minutes, 150 minutes) the subject was
      directed by a lighted sign to produce a 40-second interval by depressing a
      button. The button was connected to a microtimer which timed the interval to the
      nearest tenth second. None of the three hypotheses-1) that time would seem to
      pass more slowly in the coded than in the decoded condition: 2) that time would
      pass more slowly in the decoded than ambient condition: and 3) that as the period
      of bedrest progressed differences in duration experience would occur among the
      three groups--was supported by the data. The produced interval for ambient
      auditory information was expected to be the longest of the three groups, but the
      opposite effect occurred; it was the shortest. The significant overestimation
      that occurred in the ambient condition relative to the decoded condition appeared
      to be related to the methodological imposition of vigilance, lack of structuring
      information, and the condition of waiting. The coded auditory input did not
      effect changes in duration relative to the decoded and ambient auditory
      information as subjects were able to reorder the coded information.

PMID- 1038624
TI  - After assessment--what then?

PMID- 1038623
TI  - Problem-oriented recording as a teaching-learning tool.
AB  - The assumption that problem-oriented records help teach critical thinking was
      tested by co-paring clinical recordings and case study data for a group of
      beginning nursing students who were taught problem-oriented charting with a group
      who were taught traditional charting. No differences were found between the
      groups in the mean number of patient problems identified from a case situation.
      However, in clinical charting, the problem-oriented group identified
      significantly more patient problems and had significantly higher quality-of
      organization scores. Assuming the case situation and clinical situation were
      equivalent in presentation of identifiable problems, these findings suggested
      that the problem-oriented format was superior in allowing students to demonstrate
      their ability to identify and solve patient problems.

PMID- 1038625
TI  - Obstructions of the intestinal tract.

PMID- 1038626
TI  - Etiology of decubitus ulcers.

PMID- 1038627
TI  - Treatment of decubitus ulcers.

PMID- 1038628
TI  - Common cardiovascular problems in the postoperative period.
AB  - In summary, it should be stated that there is a basic philosophic difference
      concerning the importance and the treatment of cardiac arrhythmias in
      postoperative patients when compared to patients with myocardial infarctions. In
      the latter group the etiology for the arrhythmia is assumed, and very frequently
      correctly. In the former group of patients, the postoperative group, the etiology
      of the arrhythmia is often covert and difficult to come by. In patients with
      myocardial infarction treatment frequently is stereotyped and the effect of
      therapy often predictable. In the postoperative patient with a cardiac
      arrhythmia, be it tachycardia or an irregular pulse, the treatment may be as
      varied as the cause. Thus the thrust of our endeavor in the postoperative patient
      should be directed primarily toward determining the cause of the arrhythmia and
      thereafter administering correct therapy based on a reasonable diagnosis.

PMID- 1038629
TI  - Nursing care to assess and prevent common cardiovascular problems.

PMID- 1038630
TI  - Postoperative pulmonary complications.

PMID- 1038631
TI  - Oliguria in postoperative patients.

PMID- 1038632
TI  - Editorial: A retainer scheme for nurses?

PMID- 1038633
TI  - Four-point plan for mental handicap services.

PMID- 1038634
TI  - Euthanasia.

PMID- 1038635
TI  - A symposium on diseases of the hip in childhood. The management of congenital
      dislocation of the hip.

PMID- 1038636
TI  - Nursing treatment of congenital dislocation of the hip.

PMID- 1038638
TI  - Perthes' disease.

PMID- 1038637
TI  - Slipping of the upper femoral epiphysis.

PMID- 1038639
TI  - Lifting patients. 7. Getting out of bed.

PMID- 1038640
TI  - Management in the reorganised health service. 8. Changing times.

PMID- 1038641
TI  - TO PRESERVE LIFE!

PMID- 1038642
TI  - Part-time training for nurses.

PMID- 1038643
TI  - Nursing seven miles up.

PMID- 1038644
TI  - Rheumatic fever.

PMID- 1038645
TI  - The effect of cosmetics on the skin.

PMID- 1038646
TI  - Waiting for our patients to die.

PMID- 1038647
TI  - Lifting patients. 8. Standing up and sitting down - balance and support for
      walking.

PMID- 1038648
TI  - The problems of fostering.

PMID- 1038649
TI  - Medical costs in the EEC.

PMID- 1038650
TI  - The best bitch in the business.

PMID- 1038652
TI  - Editorial: No man is an island.

PMID- 1038651
TI  - Management in the reorganised health service. Awkward relations.

PMID- 1038653
TI  - Staffing in haemodialysis units.

PMID- 1038654
TI  - Creating a new hospital complex in Liverpool.

PMID- 1038655
TI  - Integrated health care - the aim of reorganisation.

PMID- 1038657
TI  - Hospital relations.

PMID- 1038656
TI  - Ward equipment: a review of equipment for use in hospitals, health centres, and
      nursing homes.

PMID- 1038658
TI  - Lifting patients. 9. Walking with crutches and sticks.

PMID- 1038659
TI  - Caring for the diabetic child.

PMID- 1038660
TI  - Therapeutic teams and their patients. A major relocation exercise.

PMID- 1038661
TI  - Ornithosis.

PMID- 1038662
TI  - Nursing care study: advanced disseminated sclerosis in a young woman.

PMID- 1038663
TI  - Editorial: Pig in the middle.

PMID- 1038664
TI  - The festival of spring.

PMID- 1038665
TI  - The Rcn--in or out of ICN?

PMID- 1038667
TI  - Trichomonal vaginitis.

PMID- 1038666
TI  - Childbirth in the technological age - the mother's emotional needs.

PMID- 1038668
TI  - The milk of human kindness.

PMID- 1038669
TI  - Lifting patients. 10. The hemiplegic patient.

PMID- 1038670
TI  - Horrors of the A-bomb.

PMID- 1038672
TI  - Editorial: Waste not, want not.

PMID- 1038671
TI  - Human behaviour in the work situation.

PMID- 1038673
TI  - Victory over smallpox.

PMID- 1038674
TI  - A symposium on mastectomy. Breast cancer screening.

PMID- 1038675
TI  - Surgery for breast cancer.

PMID- 1038676
TI  - Community aspects of breast cancer.

PMID- 1038678
TI  - Rehabilitation of the patient after mastectomy.

PMID- 1038677
TI  - The psychological and social consequences of breast cancer.

PMID- 1038679
TI  - Breast prostheses.

PMID- 1038680
TI  - Mastectomy--the patient's point of view.

PMID- 1038682
TI  - Training and environment.

PMID- 1038681
TI  - Another body of snoopers?

PMID- 1038683
TI  - I went into hospital.

PMID- 1038685
TI  - Publish and be damned!

PMID- 1038684
TI  - Termination of pregnancy in Wales.

PMID- 1038686
TI  - A visit to Florence Nightingale House.

PMID- 1038687
TI  - Comprehensive nurse training in Scotland - a prelude to Briggs.

PMID- 1038688
TI  - The Landry-Guillain-Barre syndrome.

PMID- 1038689
TI  - Infective arthritis.

PMID- 1038690
TI  - Nurse counselling.

PMID- 1038691
TI  - Diagnosing narcotic addiction in Hong Kong.

PMID- 1038692
TI  - Child-care customs in Colombia.

PMID- 1038693
TI  - Editorial: Abortion--an evil necessity.

PMID- 1038695
TI  - Balanced diet?

PMID- 1038694
TI  - Putting rampton on the map.

PMID- 1038696
TI  - Wheelchairs.

PMID- 1038698
TI  - Lifting patients. 4. The three or two person total lift.

PMID- 1038699
TI  - Management in the reorganised health service. 5. Money matters.

PMID- 1038697
TI  - Industrial burns and scalds.

PMID- 1038700
TI  - Research and the problem of pressure sores.

PMID- 1038702
TI  - The role of the ward sister.

PMID- 1038701
TI  - Minor eye injuries.

PMID- 1038703
TI  - Hospital insomnia.

PMID- 1038704
TI  - The changing face of hospital.

PMID- 1038706
TI  - The Dukeries Centre; King's Mill Hospital, Sutton-in-Ashfield.

PMID- 1038705
TI  - GP attachment and psychiatric domiciliary nursing.

PMID- 1038707
TI  - The old folks.

PMID- 1038708
TI  - Hoists.

PMID- 1038709
TI  - Management in the reorganised health service. 6. Best laid plans.

PMID- 1038710
TI  - Disorders of the lacrimal system.

PMID- 1038711
TI  - Alcoholism.

PMID- 1038712
TI  - Lifting patients. 5. Rocking and axillary lift.

PMID- 1038713
TI  - Are mental hospitals really necessary?

PMID- 1038714
TI  - Take 27 tablets daily.

PMID- 1038715
TI  - Editorial: One kidney can save two lives.

PMID- 1038716
TI  - Elizabeth Garrett Anderson Hospital.

PMID- 1038717
TI  - Redevelopment at risk at Hammersmith Hospital.

PMID- 1038718
TI  - Prison nursing.

PMID- 1038719
TI  - Carcinoma of the vulva.

PMID- 1038720
TI  - Lifting patients. 6. The elbow lift.

PMID- 1038722
TI  - Management in the reorganised health service. 7. Personnel priorities.

PMID- 1038721
TI  - Assessment of the elderly.

PMID- 1038723
TI  - Middlesbrough General Hospital neurology unit.

PMID- 1038724
TI  - Home care scheme in Paddington.

PMID- 1038725
TI  - The nurse's role in the home care unit.

PMID- 1038726
TI  - A bonus for the "beau" nurse.

PMID- 1038727
TI  - Adopted children in a psychiatric in-patient unit.

PMID- 1038729
TI  - Nurses' attitudes to conditions of employment.

PMID- 1038728
TI  - Outline of post basic courses for registered nurses.

PMID- 1038730
TI  - A study of alternate sites for basic nursing education.

PMID- 1038731
TI  - [Mutability of the organism].

PMID- 1038732
TI  - [Disinfection methods].

PMID- 1038733
TI  - [Instruction within the institute--but what kind].

PMID- 1038734
TI  - [Medical secretaries].

PMID- 1038735
TI  - [In a Warsaw Hospital].

PMID- 1038736
TI  - [Reflections after a visit].

PMID- 1038737
TI  - [Is there an epidemic of cancer?].

PMID- 1038738
TI  - [Anthrax].

PMID- 1038739
TI  - [On the problem of nursing terminology (continuation of the discussion)].

PMID- 1038740
TI  - [How to work more efficiently (4) Improvement].

PMID- 1038741
TI  - [Decreases in the nursing field].

PMID- 1038742
TI  - [Mutability of the organism].

PMID- 1038743
TI  - [Intramural studies--courses for nursing education].

PMID- 1038744
TI  - [Psychiatric nurse].

PMID- 1038745
TI  - [Health Centers at Studziennica and Parchonice].

PMID- 1038746
TI  - [Therapeutic community].

PMID- 1038747
TI  - [Tumors].

PMID- 1038748
TI  - [Nursing instructor].

PMID- 1038749
TI  - [This is our 17 millionth].

PMID- 1038750
TI  - [Continuing education].

PMID- 1038751
TI  - [Good equipment and furnishings for the operation of the facility].

PMID- 1038752
TI  - [Why in this manner...].

PMID- 1038753
TI  - [Protective clothing].

PMID- 1038754
TI  - [Diseases in children--genetic mutation].

PMID- 1038755
TI  - [The fight against cancer in Poland].

PMID- 1038756
TI  - [Psychotherapy--does youth need it?].

PMID- 1038757
TI  - [The work of the head nurse].

PMID- 1038758
TI  - Patient care teams in the community.

PMID- 1038760
TI  - The Queen's Nursing Institute.

PMID- 1038759
TI  - The new responsibilities for the nurse in the community.

PMID- 1038761
TI  - Caring for one another.

PMID- 1038762
TI  - The district nurse.

PMID- 1038764
TI  - Breast prostheses.

PMID- 1038763
TI  - Post-traumatic cosmetic surgery.

PMID- 1038765
TI  - Deformities of the feet.

PMID- 1038766
TI  - Caring for one another. II. The primary team speaks on the concept.

PMID- 1038767
TI  - Training to meet the future needs.

PMID- 1038768
TI  - The Panel of Assessors for district nurse training.

PMID- 1038769
TI  - Care of the cancer patient--a personal view.

PMID- 1038771
TI  - The effects of hair cosmetics.

PMID- 1038770
TI  - Nursing within the reorganised health service.

PMID- 1038772
TI  - Membership of a community health council.

PMID- 1038773
TI  - Rehabilitation and the district nurse.

PMID- 1038774
TI  - The two faces of general practice.

PMID- 1038776
TI  - Family practice nurse.

PMID- 1038775
TI  - A visit to Sweden.

PMID- 1038777
TI  - Return from overseas visit.

PMID- 1038778
TI  - Focus on the quality oflife.

PMID- 1038779
TI  - [Phono-mechanographic recordings in cardiology; their significance and their
      limitations].

PMID- 1038780
TI  - [What to do in case of syncope].

PMID- 1038781
TI  - [Gout and hyperuricemia].

PMID- 1038782
TI  - [Working women, their social abilities and adaptability to urban life].

PMID- 1038783
TI  - [Observations on Venezuela].

PMID- 1038784
TI  - [Development of and participation in the 17th International Conference for Social
      Action in Nairobi, July 14-24, 1974].

PMID- 1038785
TI  - [Care of pregnant women is far from being satisfactory].

PMID- 1038786
TI  - [In-camera observations on medical information of the public].

PMID- 1038787
TI  - [Non-hospital nurses in search of public health].

PMID- 1038788
TI  - [Normobaric oxygen therapy].

PMID- 1038789
TI  - [The nurses, a species on the road to extinction, should be protected].

PMID- 1038790
TI  - [Post-streptococcal inflammatory syndromes: classification, treatment and
      prevention].

PMID- 1038791
TI  - [The nurse and the law; public responsibility].

PMID- 1038792
TI  - [Nurse's role in barbiturate coma].

PMID- 1038793
TI  - [Myocardial biopsy].

PMID- 1038794
TI  - [Cancer of the stomach. 1].

PMID- 1038795
TI  - [The ecological press].

PMID- 1038796
TI  - [Medicine in a fever, one requests a physician...].

PMID- 1038797
TI  - [Contraception tomorrow].

PMID- 1038798
TI  - [Concentration-reinjection of ascitic fluid in patients with cirrhosis].

PMID- 1038799
TI  - Rotating tourniquets: how effective in left heart failure?

PMID- 1038800
TI  - Rotating tourniquets: the nurse's role.

PMID- 1038801
TI  - Add another: NICUs make their debut.

PMID- 1038802
TI  - Reconstruction of external genitalia in bladder exstrophy.

PMID- 1038803
TI  - Your OR gown: barrier or gateway for bacteria?

PMID- 1038804
TI  - New approach to intractable pain.

PMID- 1038805
TI  - Mature or immature? Assessing gestational age.

PMID- 1038807
TI  - RN survey of night nurses. Part 3. Night nurse: at the center of a team.

PMID- 1038806
TI  - Reducing the patient's fear of the recovery room.

PMID- 1038808
TI  - What nurses need to know about hypnosis.

PMID- 1038809
TI  - Drug therapy today. Keeping up with venereal disease.

PMID- 1038810
TI  - Managing your money. Your 1975 budget: plan well to spend wisely.

PMID- 1038811
TI  - Can you recognize heart sounds in diastole?

PMID- 1038812
TI  - Let psychiatric R.N.s do ED consultations?

PMID- 1038813
TI  - Emergency treatment of neck injuries.

PMID- 1038814
TI  - Are routine admission signs really reliable?

PMID- 1038815
TI  - Basic surgery. 4. Surgery for peptic ulcer.

PMID- 1038816
TI  - How nursing leaders see your expanding role.

PMID- 1038817
TI  - Four distinctive views of the dying patient. What is a day of life worth?

PMID- 1038818
TI  - Four distinctive views of the dying patient. "Turn the respirator off and let
      Danny die".

PMID- 1038820
TI  - Orthopedic nursing. Part 3. Control of pain in orthopedic patients.

PMID- 1038819
TI  - Four distinctive views of the dying patient. Managing terminal care of herself.

PMID- 1038821
TI  - The lingering danger of head injuries.

PMID- 1038822
TI  - Funny things happen on the way to becoming a nurse.

PMID- 1038823
TI  - Reducing the risk in relocating the elderly.

PMID- 1038824
TI  - Understanding and treating cardiogenic shock.

PMID- 1038825
TI  - Managing your money. Giving your house more than a spring cleaning.

PMID- 1038826
TI  - Experiments in nursing: spotting coronary risks among the healthy.

PMID- 1038827
TI  - Tips from the surgical ICU: how to head off respiratory crisis.

PMID- 1038828
TI  - A reappraisal of fever in acute MI.

PMID- 1038830
TI  - Managing your money. Restoring the art of department-store shopping.

PMID- 1038829
TI  - Treating the drug abuser in the ED.

PMID- 1038831
TI  - Autotransfusion: promising alternative to donor blood.

PMID- 1038832
TI  - Handling the difficult patient. Five days of abuse was enough.

PMID- 1038833
TI  - Handling the difficult patient. Sometimes you need more than cooperation.

PMID- 1038834
TI  - Handling the difficult patient. A lesson in caring - from a brat.

PMID- 1038835
TI  - Directing your care to the lupus patient's needs.

PMID- 1038836
TI  - For severe pain, self-medication on demand.

PMID- 1038837
TI  - Adjusting medications for the needs of the elderly.

PMID- 1038838
TI  - Expanding R.N. roles at the grass-roots level.

PMID- 1038839
TI  - Law for the nurse supervisor: more about abortion decisions.

PMID- 1038840
TI  - Supervisor overseas: Royal College of Nursing and ICN.

PMID- 1038842
TI  - Counter-aggression toward patients: the hidden enemy.

PMID- 1038841
TI  - JCHA (Joint Commission Commission on Accreditation of Hospitals) accreditation.
      Part 2.

PMID- 1038843
TI  - Matching personalities with position: a study of job satisfaction.

PMID- 1038844
TI  - Editorial: Malfunction in the "joint".

PMID- 1038845
TI  - The extended work day--two years later.

PMID- 1038846
TI  - Happiness is nursing ... if ...

PMID- 1038848
TI  - An old concept brought up-to-date.

PMID- 1038847
TI  - Keeping fit with Bonnie.

PMID- 1038849
TI  - Continuing education: making certain that it works.

PMID- 1038851
TI  - Counterpoint--work together for survival.

PMID- 1038850
TI  - Point--O.R. nursing becoming extinct?

PMID- 1038852
TI  - Necrotizing enterocolitis.

PMID- 1038853
TI  - Emotional aspects of hospitalised children.

PMID- 1038854
TI  - Occupational health nursing in the hospital setting.

PMID- 1038855
TI  - [The significance of being ill; a clinical-psychological consideration].

PMID- 1038857
TI  - The role of the occupational health nurse in the lead-using industry.

PMID- 1038856
TI  - [Delayed speech and language development].

PMID- 1038858
TI  - [Community psychiatry in a Bantu rural area].

PMID- 1038859
TI  - [The use of a process report in nursing education].

PMID- 1038860
TI  - Gamma radiation sterilisation.

PMID- 1038861
TI  - Daily care of the newborn infant with reference to early warning signs of
      complications.

PMID- 1038862
TI  - [Government labor insurance protects against unemployment].

PMID- 1038863
TI  - [Provincial government removes thousands of nursing positions].

PMID- 1038864
TI  - [New legislation on liability].

PMID- 1038865
TI  - [At the start of a new working year].

PMID- 1038866
TI  - [The operating room staff and hospital infections].

PMID- 1038867
TI  - JCAH (Joint Commission on Accreditation of Hospitals) accreditation. Part 1.

PMID- 1038868
TI  - A management course revisited.

PMID- 1038869
TI  - Hospital disinfection of thermometers.

PMID- 1038870
TI  - Learning tools selection.

PMID- 1038871
TI  - I traveled the mastectomy road.

PMID- 1038872
TI  - Supervisor overseas: pay rises for UK nurses.

PMID- 1038873
TI  - Legality of the problem-oriented chart.

PMID- 1038874
TI  - Letters to the Editor: Power, freedom and professional practice in nursing.

PMID- 1038876
TI  - The ICN-RCN misunderstanding.

PMID- 1038875
TI  - The art and science of supervision. Alienation in the hospital.

PMID- 1038877
TI  - Law for the nurse supervisor. Legal implications of PSRO's.

PMID- 1038878
TI  - Integrated staffing for a special care unit.

PMID- 1038879
TI  - A skills check list for orientation of associate degree nurses.

PMID- 1038880
TI  - Call me Miss!!

PMID- 1038881
TI  - The effective use of the clinical specialist.

PMID- 1038882
TI  - A new oral electrolyte in calf scours therapy.

PMID- 1038884
TI  - Early pregnancy diagnosis in swine.

PMID- 1038885
TI  - A new mink enteritis: an initial report.

PMID- 1038883
TI  - Benzathine cloxacillin intramammary infusion for treatment of mastitis in dry
      cows.

PMID- 1038886
TI  - Primary renal amyloidosis in a cow.

PMID- 1038887
TI  - A simple cryosurgical unit for treatment of animal tumors.

PMID- 1038888
TI  - Meningioma in a young dog resulting in blindness and retinal degeneration.

PMID- 1038889
TI  - Cardiomyopathy and thromboembolism in the cat.

PMID- 1038890
TI  - High-voltage electric shock in a cat.

PMID- 1038891
TI  - Necropsy findings of renal secondary hyperparathyroidism in a 1-year-old dog.

PMID- 1038892
TI  - Surgical correction of medial patellar luxation: tibial crest transplantation and
      trochlear arthroplasty.

PMID- 1038893
TI  - Ultrastructural pathology of lung worm (Filaroides milksi) infection in a dog.

PMID- 1038894
TI  - Collection of stallion semen.

PMID- 1038895
TI  - Electrophoretic pattern of serum protein in clinically normal horses and ponies
      with laminitis.

PMID- 1038896
TI  - Mental inertia: how to overcome it.

PMID- 1038897
TI  - For a worry-free retirement start planning early.

PMID- 1038898
TI  - Close-up and flash photography.

PMID- 1038899
TI  - Management of critically injured patients.

PMID- 1038900
TI  - Smoke inhalation in the dog: current concepts of pathophysiology and management.

PMID- 1038901
TI  - Feline anthelmintics: a comparative evaluation of six products.

PMID- 1038902
TI  - Paracostal exposure for correction of diaphragmatic hernia.

PMID- 1038903
TI  - Surgical repair of cleft palate.

PMID- 1038904
TI  - Surgical procedure for selective removal of canine fetuses at mid-term and beyond
      without effecting abortion (application in deafness research).

PMID- 1038905
TI  - Bovine virus diarrhea vaccines. A comparison of two virus strains.

PMID- 1038906
TI  - A note on the mastitis, metritis and agalactia syndrome in sows in Israel.

PMID- 1038907
TI  - Intramedullary pinning of femoral fracture in a calf/a photo essay.

PMID- 1038908
TI  - Severe equine pleuritis due to wire penetration.

PMID- 1038909
TI  - Cuterebra infestation of the conjunctiva in a puppy.

PMID- 1038910
TI  - The white-tiger enigma.

PMID- 1038911
TI  - How to educate the non-reader.

PMID- 1038912
TI  - Life insurance for the sole proprietor.

PMID- 1038913
TI  - Editorial: Duties and position of the nurse.

PMID- 1038914
TI  - Whither nursing.

PMID- 1038915
TI  - Public Health Nurses Working Party.

PMID- 1038916
TI  - [Poisoning with sedatives: measures carried out in the intensive care station].

PMID- 1038917
TI  - [The problem oriented system for patient-centered care].

PMID- 1038918
TI  - [Being deaf and living today. I].

PMID- 1038919
TI  - [Mental stimulation of the elderly in a group center].

PMID- 1038920
TI  - [Organization of holidays for the elderly].

PMID- 1038921
TI  - [Mental stimulation of the elderly in the group center].

PMID- 1038922
TI  - [Poisoning with sedatives: measures which can be carried out outside of the
      hospital and in first aid stations].

PMID- 1038923
TI  - [Should an incurable patient be told the truth?].

PMID- 1038924
TI  - [Principles and contributions of the Swiss Red Cross to the development of
      nursing education in Switzerland].

PMID- 1038925
TI  - [The nurse and electronic data processing].

PMID- 1038926
TI  - [The health-disease concept].

PMID- 1038927
TI  - [Does the hospital render service to time or to the patient].

PMID- 1038928
TI  - [A survey of problems of independence in paraplegics].

PMID- 1038929
TI  - [Being deaf and living today. II].

PMID- 1038930
TI  - [Nursing care in a changing world].

PMID- 1038931
TI  - [Observation on our new operating rooms which, actually, are no longer new].

PMID- 1038932
TI  - [Psychological aspects in activities of nurses working in a resuscitation and
      anesthesiology unit].

PMID- 1038933
TI  - [Health worker and education].

PMID- 1038934
TI  - [Complex rehabilitation care of chronic patients in a psychiatric unit].

PMID- 1038935
TI  - [Directed pharmacotherapy and proper economics with drugs and health supplies].

PMID- 1038937
TI  - [The future of the socialist health worker].

PMID- 1038936
TI  - [Tobacco and the lungs].

PMID- 1038938
TI  - [Training and educational function of our health schools].

PMID- 1038939
TI  - [Rendering hospital services to the rural population of the industrial region].

PMID- 1038940
TI  - [Dynamics of physical development and state of health of the pupils of Moscow's
      boarding schools].

PMID- 1038941
TI  - [Increasing interest of the district therapeutists in their work].

PMID- 1038942
TI  - [Methodological and methodical aspects of the evaluation of scientific research
      at a medical scientific research institute].

PMID- 1038943
TI  - [Importance of extra-curricular training of the students of the year in forming
      professional opinions].

PMID- 1038944
TI  - [Public contest for a plan for a better labor union medical section, better
      health center for an industrial plant].

PMID- 1038945
TI  - [Preparing and conducting operative meetings].

PMID- 1038946
TI  - [Improvement of the control of the polyclinical service to the population].

PMID- 1038947
TI  - Nurse anesthetist-anesthesiologist relationships: past, present, and implications
      for the future.

PMID- 1038948
TI  - Utilizing local spray intubation.

PMID- 1038949
TI  - Successful intervention of malignant hyperpyrexia.

PMID- 1038951
TI  - Solidarity with the profession. The protection of all nurses in employment
      policies.

PMID- 1038950
TI  - A case study of the transurethral resection of the prostate gland.

PMID- 1038952
TI  - Children too have rights!

PMID- 1038953
TI  - A totally new classification of tuberculosis.

PMID- 1038954
TI  - Treating tuberculosis infection.

PMID- 1038955
TI  - Health maintenance organizations: are HMOs the answer to your medical needs?

PMID- 1038957
TI  - A nurse shows how to help the patient stop smoking.

PMID- 1038956
TI  - Lung disease in children.

PMID- 1038958
TI  - Cigarette smoking, an American tragedy.

PMID- 1038960
TI  - Editorial: Should Federation be a nursing superorganization?

PMID- 1038959
TI  - This doctor is firm: "I advise my patients not to smoke".

PMID- 1038961
TI  - Advice for nurses planning OR inservice programs.

PMID- 1038962
TI  - Change now creates the future.

PMID- 1038963
TI  - Recovery room: past, present, and future.

PMID- 1038964
TI  - Body image and surgical alterations.

PMID- 1038965
TI  - A dialogue in adult learning.

PMID- 1038966
TI  - Anesthesia, methods to recovery.

PMID- 1038967
TI  - A therapeutic community for the dying.

PMID- 1038968
TI  - Nurses concerned with hazards of waste gases.

PMID- 1038970
TI  - The impact of nursing diagnosis.

PMID- 1038969
TI  - Criterion--referenced teaching and testing.

PMID- 1038971
TI  - Establishing, implementing, and enforcing OR policies.

PMID- 1038972
TI  - Baromedical nursing combines critical, acute, chronic care.

PMID- 1038974
TI  - A sharing of daily routine at SL/TCH/THI (St. Luke's, Texas Children's Hospital,
      Texas Heart Institute).

PMID- 1038973
TI  - Basics of packaging.

PMID- 1038975
TI  - Editorial: Who wins in malpractice sweepstakes?

PMID- 1038976
TI  - Guest editorial: Barrier standards are statements of principle.

PMID- 1038977
TI  - Self-actualizing nurse upsets, yet enriches OR.

PMID- 1038978
TI  - [Message from the General Director of the World Health Organization].

PMID- 1038979
TI  - [Foreword by the Federal Minister for Youth, Family and Health].

PMID- 1038980
TI  - [New regulations for compulsory smallpox vaccination. Decision of the plenary
      session of the Federal Health Council on November 25 and 26, 1974].

PMID- 1038981
TI  - [Tetanus prevention - why and how?].

PMID- 1038982
TI  - [Remobilization, rehabilitation, resocialization].

PMID- 1038983
TI  - [Non-resident status - the halfway houses as a resocialization place].

PMID- 1038984
TI  - [Social casework as problem solving process].

PMID- 1038985
TI  - [The group and its dynamics. 2].

PMID- 1038986
TI  - [Measles vaccination - a decisive progress].

PMID- 1038987
TI  - [Nursing care report of an educational observation (Meningococcal meningitis)].

PMID- 1038988
TI  - [On the spirit of friendship].

PMID- 1038989
TI  - [The group and its dynamics. 3].

PMID- 1038990
TI  - [Observations on relations between nursing personnel and patients].

PMID- 1038991
TI  - [Enzyme diagnosis].

PMID- 1038992
TI  - [Combined session of the International Labor organization and the World Health
      Organization on job and economic conditions of hospital personnel, from 19-30
      November, 1973 in Geneva. 1].

PMID- 1038993
TI  - [Developmental abnormalities of the skull in children].

PMID- 1038994
TI  - [Nursing care report of an educational observation (amniotic fluid aspiration)].

PMID- 1038995
TI  - [Personal reflections on the development of the Nursing Regulation on the
      practice of nursing care in the hospital].

PMID- 1038996
TI  - [The library of the H.I.V. (Higher institute of Nursing) in Antwerp].

PMID- 1038997
TI  - [Should the patient be told the truth?].

PMID- 1038998
TI  - [Campaign against an age-old illness: cancer].

PMID- 1038999
TI  - [Message from the Belgian Society for the Control of Mucoviscidosis].

PMID- 1039000
TI  - [The problem of the relations between month of birth and psychic disorders
      (author's transl)].
AB  - Groups of 730 each Schizophrenics, Affectpsychotics, and Psychopaths of
      approximately the same age are compared with 3.650 controls according to their
      month-of-birth-frequency distribution. (Also included in the comparison are 
      Schizophrenics, Manic-depressifs, Psychopaths, Hysterics as well as the siblings
      of the Manic-depressifs and Psychopaths of the study by Lang, 1931.)
      Schizophrenics show significant deviations in the total yearly distribution of
      birth as well as in 2 or 3 consecutive months - increased birth-frequency in
      November, December, January, decreased birth-frequency in February, March and in
      August, September. In the case of the Affectpsychotics only significant decreased
      birth-frequency can be detected for March. The month-of-birth-frequency
      distribution for Psychopaths is for the most part identical with that of the
      control group. The results are compared with the existing studies in this field
      of research, and possible biological explanations are discussed. Further research
      is necessary to identify the pathogenetic factors.

PMID- 1039001
TI  - [Clinical picture of acute viral encephalitides (author's transl)].
AB  - 1. This report is concerned with 44 cases of acute viral encephalitides which
      were seen in the eight-year period 1965-72. 2. There is a significant difference
      in sex distribution: 63% males and 37% females. Nearly two-thirds of our patients
      were aged up to 30 years. There is no seasonal accumulation of incidence of the
      sporadic encephalitides. 3. The clinical diagnosis was based on "influenza-like"
      preliminary symptoms (25 patients), acute onset of neurological symptoms (30
      patients) with signs of cerebral alterations like headache, drowsiness, confusion
      and epilepsy (22 patients), partly focal neurological signs (14 patients),
      inflammatory cerebro-spinal fluid alterations (36 patients) and other virus
      caused simultaneous diseases like myocarditis, hepatitis, pneumonia and
      exanthemata (19 patients). Alterations of blood sedimentation rate, number of
      white or red blood cells and differential blood count have no bearing on rapid
      diagnosis of acute viral encephalitides. Results of usual virological
      examinations often come to late for early diagnosis. Neuro-radiological
      procedures and isotope encephalography cannot help to get diagnosis in the
      initialphase of encephalitis. 4. 6 patients died, 5 had residual neurological
      deficit. 33 patients recovered completely though they partly had severe
      encephalitides. 5. There is no spezific treatment of acute viral encephalitides.
      Application of cortisone and antipyretic drugs is not indicated. 6. Most of the
      viral encephalitides may be classified when an extensive virological examination
      will be carried out.

PMID- 1039004
TI  - [Antilipemic agents].

PMID- 1039003
TI  - [Diagnosis of fever].

PMID- 1039002
TI  - [Contraceptive aids].

PMID- 1039005
TI  - [Familial idiopathic hemochromatosis].

PMID- 1039006
TI  - Retention and withdrawal of student nurses.

PMID- 1039008
TI  - Organizational dilemmas in the changing field of adult education.

PMID- 1039007
TI  - Creating a healthy institutional environment for the elderly via behavior
      management: The nurse as a change agent.

PMID- 1039009
TI  - Professional process task analysis: use of theory.

PMID- 1039010
TI  - Health manpower education and training role and responsibility of hospitals and
      other health care agencies.

PMID- 1039011
TI  - Registered nurse/licensed practical nurse orientation program.

PMID- 1039012
TI  - An editorial exploration:--A profile on ERIC; Educational Resources Information
      Center.

PMID- 1039013
TI  - A neuropharmacologic approach to self-mutilating behavior.

PMID- 1039014
TI  - When IRS picks your return for an audit.

PMID- 1039015
TI  - No-fault insurance for malpractice?

PMID- 1039016
TI  - Hypertension: diagnosis and management guidelines.

PMID- 1039017
TI  - Hemoglobin levels in the first year of life.

PMID- 1039018
TI  - Radiographic signs of early Legg-Calve-Perthes disease.

PMID- 1039019
TI  - Intrathoracic splenosis: report of a case.

PMID- 1039020
TI  - Obstruction by orange phytobezoar following partial gastrectomy: report of a
      case.

PMID- 1039021
TI  - Abdominal pregnancy: report of a case with review of the literature.

PMID- 1039022
TI  - Lesioned behavior in the upper thoracic area of the established hypertensive: a
      clinical survey of 1,000 patients.

PMID- 1039023
TI  - Skin points of anomalously low electric resistance: current-voltage
      characteristics and relationships to peripheral stimulation therapies.

PMID- 1039024
TI  - Trophic effects of nerve extracts on growth of myoblasts.

PMID- 1039025
TI  - Assessment of pulmonary edema in acute congestive heart failure with impedance
      cardiography.

PMID- 1039026
TI  - An ultrastructural investigation of the trophic role of the nerve in development
      and maintenance of muscle.

PMID- 1039027
TI  - Effect of experimental dermatophyte infection on cutaneous flora.
AB  - The cutaneous aerobic bacterial flora was monitored during the course of
      experimental dermatiphyte (ringworm) infections on the forearms of 9 volunteers.
      Micrococcaceae were identified by the new Baird-Parker classification with the
      aid of a replica-plating technique. There were significant differences in total
      populations but not in kinds of flora compared with control (opposite) forearms.
      The proportion of penicillin-resistant microorganisms, however increased the
      infection, to a degree which varied as to individual. All coccal groups were
      affected; resistant flora diminished when the fungus was no longer DETECTED.
      Staphylococci were more frequently isolated than micrococci on the infected
      areas, but Staphylococcus aureus was not found. Trends toward hierarchies in
      persistance and quantities IV were observed among the flora, with Staphylococcus
      subgroups II and dominating the infected sites. On both areas almost all
      diphtheroids were nonfluorescent, lipophilic, and lipolytic. One subject
      consistently carried Bacillus firmus; another's normal microbiota contained
      Alcaligenes faecalis.

PMID- 1039028
TI  - Labor relations and the nursing leader. Strike with honor.

PMID- 1039029
TI  - A contemporary organizational design for maternal and infant care projects.

PMID- 1039030
TI  - Nursing manpower: issues and trends.

PMID- 1039031
TI  - "Bed and bath teams": one solution to the weekend staffing shortage.

PMID- 1039032
TI  - The hospital setting and patient care outcomes. Part II.

PMID- 1039034
TI  - Nutritional considerations in radiation and chemotherapy.

PMID- 1039033
TI  - Editorial: Quality of life.

PMID- 1039035
TI  - Cancer of the colon and rectum: cure or crisis. Part III. Appliances.

PMID- 1039036
TI  - Collective bargaining: what's it all about and what can it do for you? III.

PMID- 1039037
TI  - Inside inflammatory bowel disease.

PMID- 1039038
TI  - Role reversal can be rugged. When your patient is a nurse.

PMID- 1039039
TI  - Office nursing; exciting, expanding, demanding.

PMID- 1039040
TI  - I need a friend.

PMID- 1039041
TI  - [Membrane oxygenator for the treatment of respiratory distress syndrome (author's
      transl)].
AB  - This report deals with the extracorporeal oxygenation in the respiratory distress
      syndrome. Investigations were performed with a membrane oxygenator. If one
      considers the present results, one might suppose an extracorporeal oxygenation
      without pumping-system to be ineffective. There are many different complications.
      It is doubtful whether this method will ever be an effective and sufficient
      therapy in respiratory distress syndrome.

PMID- 1039042
TI  - Child abuse in the school-age population.

PMID- 1039043
TI  - What the school health team should know about sickle cell anemia.

PMID- 1039044
TI  - Health education research: accomplishment or exercise.

PMID- 1039045
TI  - Development of an instrument to measure attitudes toward the personal use of
      premarital contraception.

PMID- 1039046
TI  - Growth in disadvantaged black children.

PMID- 1039047
TI  - Health instruction practices and problems of selected New York City elementary
      school teachers.

PMID- 1039048
TI  - Role relationships in a school health interdisciplinary team.

PMID- 1039049
TI  - Dangers of baby feeds that are too concentrated.

PMID- 1039050
TI  - Active management of labour.

PMID- 1039051
TI  - Attitudes of a group of mothers to breast feeding. Part I.

PMID- 1039052
TI  - A time to be born.

PMID- 1039053
TI  - Review of infant foods. RCM recommendations.

PMID- 1039054
TI  - Guidelines for teachers of parentcraft and relaxation. Session 4: labour.

PMID- 1039055
TI  - Whitley Council agreement on annual leave and public holidays.

PMID- 1039056
TI  - The midwifery profession in France.

PMID- 1039057
TI  - HMS etcetera.

PMID- 1039058
TI  - Treatment of industrial injury: hospital or OH service?

PMID- 1039059
TI  - Practitioners' duties.

PMID- 1039061
TI  - The need to evaluate OH.

PMID- 1039060
TI  - OH in Europe. 4. Italy.

PMID- 1039062
TI  - [Establishing liability].

PMID- 1039063
TI  - [Understanding the patient's personality].

PMID- 1039064
TI  - [Proposal for the determination of abilities and limitation of functions of
      nursing assistants].

PMID- 1039065
TI  - [Discussion about a planning board which can be used for exhibiting in hospital
      administration].

PMID- 1039066
TI  - [The elderly person in the family. A carefree old age in security].

PMID- 1039068
TI  - Editorial: Message from the President.

PMID- 1039067
TI  - Selecting the software.

PMID- 1039069
TI  - Clinical knowledge: a needed curriculum emphasis.

PMID- 1039070
TI  - From invisibility to blackness: the story of the National Black Nurses'
      Association.

PMID- 1039071
TI  - A model for clinical evaluation.

PMID- 1039072
TI  - The Soviet nurse emigre in Israel.

PMID- 1039073
TI  - A nursing course for medical students.

PMID- 1039075
TI  - Acupuncture ...in your hospital?

PMID- 1039074
TI  - Continuing education for the specialty nurse.

PMID- 1039076
TI  - The Child Health Conference.

PMID- 1039077
TI  - Jasper.

PMID- 1039078
TI  - [Helping the hysteriac].

PMID- 1039079
TI  - A study of the use of hypnotics and tranquilizers.

PMID- 1039080
TI  - Never too old to vote.

PMID- 1039081
TI  - The medical director in the long-term care facility.

PMID- 1039082
TI  - What makes successful aging?

PMID- 1039083
TI  - Exploration of the emotional feelings of the elderly confined to a nursing home.

PMID- 1039084
TI  - [General surveillance by the head nurse responsible for nursing care].

PMID- 1039085
TI  - [Femeral neck fractures].

PMID- 1039086
TI  - [Headache. 1. Intracranial hypertension].

PMID- 1039087
TI  - [Blood transfusion. I. Whole blood transfusion].

PMID- 1039088
TI  - [Health, economic realities].

PMID- 1039089
TI  - [With the Indians of the Orinoco].

PMID- 1039090
TI  - [Industrial medicine in metallurgy].

PMID- 1039091
TI  - [Chronic pancreatitis].

PMID- 1039092
TI  - [Course of management of leukoneutropenia in adults].

PMID- 1039093
TI  - [Blood transfusion. 2. Blood derivatives and plasma fractions].

PMID- 1039094
TI  - [Societies of benevolent public charity or withdrawal of the state?].

PMID- 1039096
TI  - [10 years of medical research].

PMID- 1039095
TI  - [The pregnant woman and drugs].

PMID- 1039097
TI  - [The ideal nurse].

PMID- 1039098
TI  - [Boarding school for diabetic children].

PMID- 1039099
TI  - [Motivation analysis in the hospital. Theory and practice of motivation - a
      prescription for testing].

PMID- 1039101
TI  - [Surgery in newborn infants and infants].

PMID- 1039100
TI  - [Radiation protection].

PMID- 1039102
TI  - [Position of the matron in hospital administration].

PMID- 1039103
TI  - [The professional image of the public health nurse].

PMID- 1039104
TI  - [Report of the Health Manpower Committee].

PMID- 1039106
TI  - [The Chinese nurse].

PMID- 1039105
TI  - [The story of the home nursing organization].

PMID- 1039107
TI  - [1975 chosen as International Women's Year].

PMID- 1039108
TI  - [A proposed look at lowered housing expenses].

PMID- 1039109
TI  - [Nurses' Day 1975. Professional analysis of educational principles].

PMID- 1039110
TI  - [Nurses' Day 1975. Standards of nursing care in danger].

PMID- 1039111
TI  - [Nurse in Greenland].

PMID- 1039112
TI  - [Is the new personnel structure effective?].

PMID- 1039113
TI  - [Nurses' Day 1975. Shortages should have the ability to challenge the employer].

PMID- 1039114
TI  - [Finnish nurse teaches in Yemen].

PMID- 1039115
TI  - [Educational reform causes anxiety in the area].

PMID- 1039117
TI  - [Forward in cooperation].

PMID- 1039116
TI  - [Is the nurse castigated or supported?].

PMID- 1039118
TI  - [Nurse in a Greenland rural area].

PMID- 1039119
TI  - [Orientation for country roentgen nurse].

PMID- 1039120
TI  - [Dry skin and its treatment].

PMID- 1039121
TI  - [New legislation on pregnancy interruption].

PMID- 1039122
TI  - [Customary hospital food for adults].

PMID- 1039124
TI  - [Editorial: Do we take a position?].

PMID- 1039123
TI  - [A contribution to the debate on aid to developing countries].

PMID- 1039125
TI  - [Norwegian Nurses' Association statement to the Social Department on: efficiency
      engineering activities in hospital sectors].

PMID- 1039126
TI  - [If only to be a fantastic hero, is not enough in a snowmobile ...].

PMID- 1039127
TI  - [Norilco, Norwegian society for patients with colostomy, ileostomy and urostomy].

PMID- 1039128
TI  - [Disposable articles should be used only once].

PMID- 1039129
TI  - [That's why I gave up my profession].

PMID- 1039130
TI  - [Research in nursing. 2. Can you measure the effect of nursing care?].

PMID- 1039132
TI  - [Editorial: A step in the right direction].

PMID- 1039131
TI  - [Guidelines for drug control in hospitals].

PMID- 1039133
TI  - [Prison nurse works with drug addicts: we must prevent drug addicts from
      destroying themselves].

PMID- 1039134
TI  - [Campaign against p-pills is unjustified].

PMID- 1039135
TI  - [Research in nursing. 3. Qualitative methods in research do not give numerical
      evidence].

PMID- 1039136
TI  - [Bell apparatus rings when child begins to urinate].

PMID- 1039137
TI  - [Commentary on guidelines for organization of public health nursing arrangements:
      weak formulation of criteria for special assistance].

PMID- 1039138
TI  - [Nurses should be involved in the prevention of torture: use of torture has grown
      to epidemic proportions].

PMID- 1039139
TI  - [Editorial: Material enough for research].

PMID- 1039140
TI  - [We felt as if we moved around in a large vacuum].

PMID- 1039141
TI  - [Important to devote one's time to the mother of the hospitalized child].

PMID- 1039142
TI  - [Fishnets and supporting belts as aids in weighing of infants].

PMID- 1039143
TI  - [Was tortured with electroshock, kicks and fist blows for days on end: I felt as
      though my head would explode].

PMID- 1039144
TI  - [Editorial: That is an accusation for all of us].

PMID- 1039145
TI  - [Danish nurses' encounter with ugly face of war: a rocket landed in a home and
      killed 10 women and children].

PMID- 1039146
TI  - [Public health nurses' weighing of children a physical challenge].

PMID- 1039148
TI  - [Hospital fire in Stockholm costs life to 7 patients: many saved by courageous
      action of nurse].

PMID- 1039147
TI  - [Value relativism in nursing research: no limitations in research within
      nursing].

PMID- 1039149
TI  - [Swedish fire experts on fire hazards in the hospital: fire hazards should be
      considered with greatest seriousness].

PMID- 1039150
TI  - [2 European organizers establish minimum qualifications for nursing education and
      training: European Council and EEL present a variety of educational
      requirements].

PMID- 1039151
TI  - [A small hospital receives permission to continue].

PMID- 1039152
TI  - [Editorial: Problems around the hospital].

PMID- 1039153
TI  - [Experts warn against uncontrolled growth of hospital sector: Nurses should be
      more interested in administration].

PMID- 1039154
TI  - [Family therapy in relation to public health nursing functions: Family therapy
      should be an independent occupation].

PMID- 1039156
TI  - [60, 000 have received instruction in fire prevention in hospitals].

PMID- 1039155
TI  - [Health care instructors' professional affiliation].

PMID- 1039158
TI  - [A triple graded marking scale].

PMID- 1039157
TI  - [Experience of diabetes care receivers].

PMID- 1039159
TI  - [Discussion on future mental health care in Stockholm].

PMID- 1039160
TI  - [Experiences from work life still an important qualification in modern colleges].

PMID- 1039161
TI  - [New adult education support gives 1,500-2,000 KR per month].

PMID- 1039163
TI  - [Infant colic].

PMID- 1039162
TI  - [What is happening to the studies on education in psychotherapy? 2].

PMID- 1039164
TI  - [Work environment agreement 75 cleared for municipal sectors].

PMID- 1039165
TI  - [Family--employment--community].

PMID- 1039166
TI  - [6-hour working day will get ways to agreement].

PMID- 1039167
TI  - [Various impressions from a study year in the USA].

PMID- 1039168
TI  - [The occupation of nursing - a trade or a profession?].

PMID- 1039169
TI  - [On account of several books on suicide].

PMID- 1039170
TI  - [Now there is proof: parttime work gives lower wages and benefits are not
      received either].

PMID- 1039171
TI  - [Fulltime workers can become parttime pensioners in 1976].

PMID- 1039173
TI  - [An additional voice on psychiatric treatment methods].

PMID- 1039172
TI  - [Swedish Student Nurses' Association annual meeting: continuation of the campaign
      for ungraded certification].

PMID- 1039174
TI  - [Team nursing. II. Report of a study].

PMID- 1039175
TI  - [Bone cysts].

PMID- 1039176
TI  - [Nursing aspects of multiple sclerosis].

PMID- 1039177
TI  - [This is how patients can feel: no reaction to need for company].

PMID- 1039178
TI  - [Information from the clinical chemical laboratory. Thrombocyte function].

PMID- 1039180
TI  - [Anemia in women].

PMID- 1039179
TI  - [Nursing aspects of Parkinson's disease].

PMID- 1039181
TI  - [Nursing and Maslow].

PMID- 1039182
TI  - [Practice support in educational perspective].

PMID- 1039183
TI  - [The MR-nurse (mental retardation nursing) between shore and ship].

PMID- 1039184
TI  - [MR-nursing between shore and ship. The water between shore and ship].

PMID- 1039185
TI  - [Is there room for the MR-nurse in the care for the mentally retarded?].

PMID- 1039187
TI  - [This is how patients can feel: now there's something physically wrong...].

PMID- 1039186
TI  - [Influencing of blood coagulation and decoagulation of the blood].

PMID- 1039188
TI  - [Development and possibilities of all-round "cross" activities].

PMID- 1039189
TI  - [Lactose and lactose intollerance].

PMID- 1039190
TI  - [Experiences with the lactose- poor and lactose-free diet].

PMID- 1039191
TI  - [Thoughts on team nursing in psychiatry].

PMID- 1039192
TI  - [Ethics in regard to systems].

PMID- 1039193
TI  - [Head above water].

PMID- 1039194
TI  - [Evaluation methods in education: normative or criterion-referenced?].

PMID- 1039195
TI  - [Information from the clinical chemical laboratory].

PMID- 1039196
TI  - The rewards of apathy.

PMID- 1039197
TI  - Elimination of ipronidazole from the tissues of swine.

PMID- 1039198
TI  - Cutaneous horn on a Hereford cow.

PMID- 1039199
TI  - Perirenal edema in swine- caused by ingestion of amaranthus retroflexus
      (pigweed).

PMID- 1039200
TI  - Wildlife photography.

PMID- 1039201
TI  - Corneolombal squamous cell carcinoma in a horse.

PMID- 1039202
TI  - Treatment of canine paragonimiasis with bithionol acetate.

PMID- 1039203
TI  - An anti-lick device.

PMID- 1039204
TI  - Myopathy in three dogs.

PMID- 1039206
TI  - Surgical relief for urethral obstruction due to sabulous calculi in the male cat.

PMID- 1039205
TI  - Transplantation of the fascia lata to repair dorsal capsular tears to the hip
      joint after traumatic dislocation.

PMID- 1039207
TI  - A new method of abdominal & thoracic paracentesis in the dog and cat.

PMID- 1039208
TI  - Clinical trials with Tresaderm in cats.

PMID- 1039209
TI  - Use of ketamine for restraint & anesthesia of birds.

PMID- 1039210
TI  - Experimental use of aloe vera extract in clinical practice.

PMID- 1039211
TI  - Try an emotional air-conditioner in your practice.

PMID- 1039212
TI  - Where and how to get building mortgage money.

PMID- 1039213
TI  - [Predictive value of psychological tests in the framework of a nursing school].

PMID- 1039214
TI  - [Contact plate thermography in the diagnosis of breast cancer].

PMID- 1039215
TI  - [Fundamental principles and contribution of the Swiss Red Cross in the field of
      development of professional education of health care personnel in Switzerland].

PMID- 1039216
TI  - [Noise hazards in the working environment].

PMID- 1039217
TI  - [Sepsis - septicemia].

PMID- 1039218
TI  - [Gas or steam sterilization: range of application].

PMID- 1039219
TI  - [Attitude and personality of the supervisor].

PMID- 1039220
TI  - [Warning: there is no such thing as harmless cigarettes].

PMID- 1039222
TI  - [Team nursing, 20 years later...].

PMID- 1039221
TI  - [The woman's status in the hospital: relation between work productivity and
      decision making ability].

PMID- 1039223
TI  - [The significance of group dynamics in working relations of nursing personnel].

PMID- 1039224
TI  - [Training in team work].

PMID- 1039225
TI  - [Sepsis - septicemia. 2].

PMID- 1039227
TI  - [Team work from the viewpoint of group dynamics].

PMID- 1039226
TI  - [Predictive value of psychological tests in the framework of a nursing school].

PMID- 1039228
TI  - [Health-illness concept: health, illness and care personnel].

PMID- 1039229
TI  - [Noise hazards in the working environment].

PMID- 1039230
TI  - [Man and woman, equal partners?].

PMID- 1039231
TI  - [Extension of extramural nursing].

PMID- 1039232
TI  - [Are nursing standards threatened by an inadmissible reduction?].

PMID- 1039233
TI  - [Physiological-hygienic evaluation of the work of the youth in the student's
      building brigades].

PMID- 1039234
TI  - [Scientific work organization of the school physician].

PMID- 1039235
TI  - [Work of the specialized mobile brigades in rendering emergency medical aid to
      the rural population].

PMID- 1039236
TI  - [Organization of anti-alcoholism campaign at a large industrial plant].

PMID- 1039237
TI  - [Development of the stomatological aid in the Checheno-Ingush ASSR].

PMID- 1039238
TI  - [Morbidity in Dagestan (based on one region)].

PMID- 1039239
TI  - [Integrated estimation of the effect of certain medico-social factors in infant
      mortality in Omsk].

PMID- 1039240
TI  - [Organization of the Inventions Department in a multiprofile scientific-research
      institute].

PMID- 1039241
TI  - [Practical training of students in the area of social hygiene and public health
      organization].

PMID- 1039242
TI  - [Ideological strength of prospective physicians].

PMID- 1039243
TI  - [Training of scientists-an important task of the universities].

PMID- 1039244
TI  - [Organization of the work of gynecological consultants].

PMID- 1039245
TI  - [Organization of traumatological aid to the urban population].

PMID- 1039246
TI  - Temporary cardiac pacemakers.

PMID- 1039247
TI  - From student to staff nurse: a nurse internship program.

PMID- 1039248
TI  - What rewards will keep nurses on the job?

PMID- 1039249
TI  - Relieving airway obstruction in the recovery room.

PMID- 1039250
TI  - Control of violence in a mental health setting.

PMID- 1039251
TI  - Skin assessment for color and temperature.

PMID- 1039252
TI  - Infant respiratory distress syndrome.

PMID- 1039253
TI  - Peer review in a health department.

PMID- 1039254
TI  - Vasopressor agents in shock.

PMID- 1039255
TI  - Teaching mental retardation nursing.

PMID- 1039256
TI  - Meeting the emotional needs of hemodialysis patients and their spouses.

PMID- 1039257
TI  - Group sessions for the wives of home-hemodialysis patients.

PMID- 1039258
TI  - Commitment to change in Colorado.

PMID- 1039259
TI  - A paraplegic reflects.

PMID- 1039260
TI  - Helping people stretch their grocery dollars.

PMID- 1039261
TI  - What do you give and get in social secutiry?

PMID- 1039262
TI  - Programmed instruction. Patient assessment: examination of the head and neck.

PMID- 1039263
TI  - Editorial: Documentary.

PMID- 1039264
TI  - Therapeutic touch: the imprimatur of nursing.

PMID- 1039265
TI  - Administering parenteral drugs.

PMID- 1039266
TI  - Family decision: a crucial factor in terminating life.

PMID- 1039267
TI  - Hyperkinesis and learning disabilities linked to artificial food flavors and
      colors.

PMID- 1039268
TI  - The nurse practitioner and the child on the Feingold DIET.

PMID- 1039269
TI  - What do you say after you say Mm--hmm?

PMID- 1039270
TI  - Loeb Center and its philosophy of nursing.

PMID- 1039271
TI  - Central venous catherization.

PMID- 1039272
TI  - Interdisciplinary education: is it valid?

PMID- 1039273
TI  - "I like being an FNP".

PMID- 1039274
TI  - Catheterizing the maternity patient.

PMID- 1039275
TI  - Crisis intervention in acute care areas.

PMID- 1039276
TI  - Care of an artificial eye.

PMID- 1039277
TI  - Parenting during hospitalization.

PMID- 1039278
TI  - When does adequate insurance become inadequate?

PMID- 1039279
TI  - A new experimental model for the study of morphinic analgesics.

PMID- 1039280
TI  - From chaos to a structured therapeutic community: treatment programme on
      Emiliehoeve, a farm for young addicts.
AB  - Within two years a centre for young addicts emerged; from a chaotic situation
      where drug use was frequent a drug-free therapeutic community developed with a
      solid structure; encounter group techniques were the major therapeutic tool. The
      community is located on a farm providing a great variety of work situations. The
      evolution in this direction is described, pointing out the failings of several
      approaches attempted during the different phases of the programme.

PMID- 1039281
TI  - Attitudes to drug users and to the use of alcohol, tobacco and cannabis on the
      campus of a provincial university.

PMID- 1039282
TI  - "Drug abuse and its prevention" as seen by the internation legal profession.

PMID- 1039283
TI  - Understanding British addiction statistics.
AB  - The statistical data issued by the Home Office and Department of Health and
      Social Security are quite detailed and generally valid measures of hard core
      addiction in Great Britain (Judson, 1973). Since 1968, the main basis of these
      high quality British statistics is the routine reports filed by Drug Treatment
      Centres. The well-trained, experienced staff of these clinics make knowledgeable
      dicsions about a cleint's addiction, efficiently regulate dosage, and otherwise
      exert some degree of control over addicts (Judson, 1973; Johnson, 1974). The co
      operation of police, courts, prison physicians, and general practitioners is also
      valuable in collecting data on drug addiction and convictions. Information
      presented in the tables above indicates that a rising problem of herion addiction
      between 1962 and 1967 were arrested by the introduction of the treatment clinics
      in 1968. Further, legally maintained heroin addiction has been reduced by almost
      one-third since 1968, since many herion addicts have been transferred to
      injectable methadone. The decline in herion prescribing and the relatively steady
      number of narcotics addicts has apparently occurred in the face of a continuing,
      and perhaps increasing, demand for heroin and other opiates. With few exceptions
      of a minor nature analysis of various tables suggests that the official
      statistics are internally consistent. There are apparently few "hidden" addicts,
      since few unknown addicts die of overdoses or are arrested by police (Lewis,
      1973), although Blumberg (1974) indicates that some unknown users may exist. In
      addition, may opitate usersnot officially notified are known by clinic doctors as
      friends of addicts receiving prescriptions (Judson, 1973; Home Office, 1974). In
      brief, offical British drug statistics seem to be generally valid and demonstrate
      that heroin and perhaps methadone addiction has been well contained by the
      treatment clinics.

PMID- 1039284
TI  - Herion-caffeine-strychnine mixtures--where and why?

PMID- 1039285
TI  - Field and laboratory test for raw and prepared opium.
AB  - Two new colour tests for opium are described. These may be used alone, as field
      tests, or in combination with traditional tests rapidly to confirm raw or
      prepared opium. Absolute confirmation of opium by thin layer chromatography is
      also useful in the determination of origins. An alternative chromogen to the
      Dragedorff reagents is described, although iodoplatinate remains the preferred
      chromogen.

PMID- 1039286
TI  - The legacy of coronary care nursing.

PMID- 1039287
TI  - [Nursing record and nursing-related records - keypoints in the nursing records
      and the modern hospital system].

PMID- 1039288
TI  - [An observation on the nursing record - on the terminology and method of
      description].

PMID- 1039289
TI  - [The nursing record and the re-evaluation of its recording method.
      Standardization of terminology vs. accuracy in describing clinical conditions].

PMID- 1039290
TI  - New broad-spectrum penicillins.

PMID- 1039291
TI  - Loneliness--a consideration in community health.

PMID- 1039293
TI  - Breakthrough has become of age.

PMID- 1039292
TI  - Why minorities in nursing?

PMID- 1039294
TI  - Eighty and alone: who will care?

PMID- 1039295
TI  - Students and change.

PMID- 1039296
TI  - A simple test for penicillinase in sputum.

PMID- 1039297
TI  - Some thoughts on an osteopathic curriculum.

PMID- 1039298
TI  - D.O. portfolio.

PMID- 1039300
TI  - Transient global amnesia.

PMID- 1039299
TI  - Colonoscopy: a review of 135 procedures.

PMID- 1039301
TI  - The relevance of somatic dysfunction.

PMID- 1039302
TI  - A logical approach for determination of fetal maturity in the community hospital.

PMID- 1039304
TI  - Records to assist osteopathic physicians.

PMID- 1039303
TI  - Calcified renal artery aneurysm with arteriovenous fistula: report of a case.

PMID- 1039305
TI  - The influence of osteopathic manipulative therapy in the management of patients
      with chronic obstructive lung disease.

PMID- 1039306
TI  - The need for education of the subject in clinical research.

PMID- 1039307
TI  - Multidisciplinary evaluation of learning and behavior problems in children: a
      follow-up study of 40 cases.

PMID- 1039308
TI  - The effect of race and income on one's interactions in the American society.

PMID- 1039309
TI  - Antitrypsin activity in serum.

PMID- 1039310
TI  - The purpose of biochemistry laboratory exercises in the medical curriculum: an
      identity crisis.

PMID- 1039311
TI  - Inactivation of cefazolin, cephaloridine, and cephalothin by methicillin
      sensitive and methicillin-resistant strains of Staphylococcus aureus.
AB  - Cefazolin was more susceptible than cephaloridine and cephalothin to in vitro
      inactivation by coagulase-positive, penicillinase-producing strains of
      Staphylococcus aureus. Inactivation (which was greater with methicillin-resistant
      than with methicillin-sensitive strains) was demonstrated by assay of the
      antibiotics in broth cultures with simultaneous colony counts and by exposure of
      the antibiotics to penicillinase powders extracted from S. aureus. Cefazolin was
      destroyed to a greater extent than was cephaloridine, whereas cephalothin
      underwent little, if any, destruction. The clinical implications of this
      degradation, thought by some to be of importance for cephaloridine, might also
      apply to cefazolin.

PMID- 1039312
TI  - Matrix organization: an alternative for clinical specialists.

PMID- 1039313
TI  - Labor relations and the nursing leader. Caught in the middle: nursing
      supervisors.

PMID- 1039314
TI  - Monitoring nursing care quality.

PMID- 1039315
TI  - Career ladder program: a problem solving device.

PMID- 1039316
TI  - A system for determining appropriate nurse staffing.

PMID- 1039317
TI  - Administrative evaluation of ambulatory care program effectiveness.

PMID- 1039318
TI  - Certifying competencies of personnel.

PMID- 1039319
TI  - Young Parents' Group.

PMID- 1039320
TI  - Teen group-medical student seminar.

PMID- 1039321
TI  - Sexual counseling; an approach to the integration of sexual counseling into the
      antepartal management of teenagers.

PMID- 1039322
TI  - Abortion counseling; what we need to know and why.

PMID- 1039323
TI  - Female urethral strictures and recurrent urinary tract infections. How to break
      the cycle.

PMID- 1039324
TI  - Disaster plan now in effect.

PMID- 1039325
TI  - The importance of touch for patient and nurse.

PMID- 1039326
TI  - Isolation isn't just a technique. Communicating with your deaf patient.

PMID- 1039327
TI  - Editorial: United we stand.

PMID- 1039328
TI  - Reaching new heights in a new day. NAPNES 34th Annual Convention.

PMID- 1039329
TI  - Activity of amoxycillin against enterococci and synergism with aminoglycoside
      antibiotics.
AB  - Amoxycillin was more active in vitro than ampicillin or benzylpenicillin against
      clinical isolates of enterococci. All 55 strains tested were sensitive to the
      three penicillins but 15 strains showed a high level of resistance to
      streptomycin and two of these were also insensitive to kanamycin. All strains
      were sensitive to gentamicin, which was the most active of the aminoglycoside
      antibiotics. The penicillins showed pronounced bactericidal activity against the
      enterococci but failed to sterilise cultures of these organisms. Combinations of
      penicillins and aminoglycosides invariably produced synergistic bactericidal
      effects which resulted in sterilisation of cultures of these organisms.
      Combinations of penicillins and aminoglycosides invariably produced synergistic
      bactericidal effects which resulted in sterilisation of cultures of enterococci
      provided that the strain was sensitive to the aminoglycoside moiety of the
      antibiotic combination. Synergism was not observed with a combination of a
      penicillin and an aminoglycoside when the enterococcus was resistant to the
      aminoglycoside. The data reported suggest that amoxycillin may have certain
      advantages, compared with ampicillin or benzylpenicillin, for the treatment of
      enterococcal infections.

PMID- 1039330
TI  - Effect of plasmid carriage on the virulence of staphylococcus aureus.
AB  - The possession of any of eight different plasmids by Staphylococcus aureus strain
      649--either singly or simultaneously (in no. 649MR)--caused changes in growth
      kinetics. Six of the plasmids caused an increase in exponential doubling time (by
      8-25%), and most also altered the duration of the lag period. Strain 649MR was
      significantly less virulent for 10-day chick embryos than the corresponding
      plasmid-negative culture (no. 649N). The avirulence persisted even after loss of
      the plasmids from no. 649MR. The presence of a single plasmid specifying
      tetracycline resistance produced a moderate reduction in virulence, but
      chromosomal tetracycline resistance had an insignificant effect on it. The
      decrease in virulence could not be attributed to reduced formation of soluble
      products. It probably resulted from alterations in the cell surface, but membrane
      polypeptide profiles of virulent and avirulent cells lacking plasmids were
      similar. Survival of strains 649MR and 649N on glass was identical. Therefore,
      reduction in the incidence of staphylococcal sepsis may be due in part to loss of
      virulence that has resulted from plasmid carriage.

PMID- 1039331
TI  - Variation in the properties of a strain of Staphylococcus aureus isolated over
      three months from a single hospital.
AB  - A strain  of Staphylococcus aureus has been isolated from a hospital environment
      over 3 months. Every isolate was lysed by phage 77, had high-level resistance to
      streptomycin, and was resistant to about 250 pg per ml of both tetracycline and
      sulphonamide; a combination of sulphamethoxazole and trimethoprim produced little
      bacteristatic synergy towards each isolate. All These organisms were thus
      considered to be "the same"; the variation in other properties was probably due
      to rapid evolutionary change in vivo. the variation in senxitivity to methicillin
      and neomycin, and the absence of penicillinase production in some isolates,
      probably indicated loss of the relevant genes. Several isolates had probably
      acquired resistance to lincomycin by a one-step mutatuon in vivo. The usefulness
      of lincomycin and analogues in treating staphylococcal infections seems limited.

PMID- 1039332
TI  - Editorial: Mortality from nutritional deficiency.

PMID- 1039333
TI  - Evolution of breast feeding in Europe.

PMID- 1039334
TI  - The prevalence of malnutrition amongst Malay pre-school children-comparative
      assessment by anthropometric indicators.

PMID- 1039335
TI  - Strategy and plan of action to combat gastro-enteritis and malnutrition in
      children under two years of age. (Formulated as requested by Resolution No. 7 of
      the 5th Caribbean Health Ministers Conference, Dominica, February 1973.

PMID- 1039336
TI  - Family planning, maternal and child health, and nutrition with special reference
      to mothers and children. Guidelines for DEIDS planning-I. August 1973.

PMID- 1039337
TI  - An evaluation of the educational benefits of nutritional rehabilitation centres
      as measured by the nutritional status of siblings.

PMID- 1039338
TI  - The unfavourable trend in infant feeding.

PMID- 1039339
TI  - The pattern of malnutrition in Zaria.

PMID- 1039340
TI  - Physical and psychological growth and development.

PMID- 1039341
TI  - Role of maternal nutritional health and care in the development and personality
      of children in Africa.

PMID- 1039342
TI  - Relationship between malnutrition and the nutrient content of staple food crops.

PMID- 1039343
TI  - Use of soya bean to improve the protein content of the diet in West Africa and
      thus prevent kwashiorkor.

PMID- 1039344
TI  - The Nigerian meal pattern.

PMID- 1039345
TI  - Measles and its problems as seen in Ghana.

PMID- 1039346
TI  - Pyogenic meningitis in childhood.

PMID- 1039347
TI  - A revival of the older methods of diagnosis and treatment of pyogenic meningitis.

PMID- 1039348
TI  - Nutritional problems among Kenyan children.

PMID- 1039349
TI  - Salmonellosis in infants.

PMID- 1039350
TI  - Organisation of emergency paediatric units.

PMID- 1039351
TI  - Paediatric fluid and electrolyte therapy.

PMID- 1039352
TI  - Glucose-electrolyte powders.

PMID- 1039353
TI  - An attitude to undergraduate education.

PMID- 1039354
TI  - Paediatric education for Nigerian nurses.

PMID- 1039356
TI  - [Midwifery activities and nursing philosophy].

PMID- 1039355
TI  - Paediatric field training unit in Malumfashi.

PMID- 1039357
TI  - [Public health nursing activities in cooperation with obstetrical clinics. The
      practice at the public health clinic located at Chikugo Obstetrical Clinic.
      Kakogawa-Shi].

PMID- 1039358
TI  - [Technic of ligation of the umbilical loop and its evaluation].

PMID- 1039359
TI  - [Perinatal mortality at Yokkaichi City Hospital in the last 5 years].

PMID- 1039360
TI  - [Successive pregnancy and deliveries (gravid 14, para 12) and frequent pregnancy
      and repeated induced abortion (gravid 13, para 2): an observation on 2 cases].

PMID- 1039361
TI  - [Definition of obstetrical terminology].

PMID- 1039363
TI  - [Retinopathy of immature infants: a current problem in midwifery practice].

PMID- 1039362
TI  - [Discussion: various problems in the practice of midwifery and the image of the
      midwife].

PMID- 1039364
TI  - [Uterine auscultation].

PMID- 1039365
TI  - [5 cases of placenta praevia and its nursing].

PMID- 1039366
TI  - [Placenta praevia and action of the obstetrical medical team].

PMID- 1039367
TI  - [Case conference: placenta praevia - an analysis by midwives].

PMID- 1039368
TI  - [Vital signs of infants - with special reference to respiration, circulation and
      temperature of newborn and young infants].

PMID- 1039369
TI  - [Care by the public health nurse of the patient with threatened abortion].

PMID- 1039371
TI  - [Discussion: obstetricians, midwives and the instruction on breast feeding].

PMID- 1039370
TI  - [Care of expectant mothers based on observation of the course of pregnancy].

PMID- 1039372
TI  - [Care of the nipples during pregnancy - with special reference to correction of
      the shape of the nipples].

PMID- 1039373
TI  - [Breast massage and other maternal care administered at our hospital].

PMID- 1039374
TI  - [Instruction on breast feeding for mothers rooming-in with their babies and for
      those with infants kept in the nursery].

PMID- 1039375
TI  - [Nursing functions in the ward for newborn and premature infants and assistance
      in breast feeding].

PMID- 1039376
TI  - [Working mothers and breast feeding].

PMID- 1039377
TI  - [Promotion of breast feeding at Yamaguchi Central Hospital].

PMID- 1039378
TI  - [Improved instruction on breast feeding and its effect at Kurashiki Central
      Hospital].

PMID- 1039380
TI  - [Current status and various problems of emergency health care in Japan].

PMID- 1039379
TI  - [Discussion: information on and technics of breast feeding].

PMID- 1039381
TI  - [Innovation in the medical services during nights and holidays - the practice at
      Takatsuki-Shimamoto Emergency Clinic for evenings and holidays].

PMID- 1039382
TI  - [The status of emergency health services to meet the local needs in Okinawa].

PMID- 1039383
TI  - [Emergency health services in isolated areas and islands - a new trial in
      Nagasaki Prefecture].

PMID- 1039384
TI  - [Emergency health services and their local characteristics of Hokkaido].

PMID- 1039385
TI  - [Organization of emergency medical information systems in Japan and its future].

PMID- 1039386
TI  - [Emergency measures at the time of disasters].

PMID- 1039387
TI  - [Human chromosomes and heredity - progress in cytogenetics].

PMID- 1039388
TI  - [Evaluation of heat sterilization].

PMID- 1039389
TI  - [Examples of emergency health services in foreign countries].

PMID- 1039390
TI  - [Nursing of emergency patients and nursing technics - the ideal form of nursing
      at the hospital emergency department].

PMID- 1039391
TI  - [Programs of nursing education at the emergency health care center].

PMID- 1039392
TI  - [Observation on the status of emergencies. Emergencies in the field of internal
      medicine - examples at an emergency hospital in Osaka].

PMID- 1039393
TI  - [Observations on the status of emergencies. Emergencies in the field of surgery -
      an observation in Osaka].

PMID- 1039394
TI  - [Observations on the status of emergencies. Emergencies in the field of
      pediatrics- an observation on cases involving the use of ambulances in Tokyo].

PMID- 1039395
TI  - [Observation on the status of emergencies. Statistics on emergency burn patients
      and various medical problems].

PMID- 1039396
TI  - [Status of emergencies and their transport system in Tokyo].

PMID- 1039397
TI  - [Nursing of a patient with facial bone fracture in a traffic accident].

PMID- 1039398
TI  - [Psychological problems of parents of children afflicted with deformities - an
      approach to the parents and children].

PMID- 1039399
TI  - [Progress and the current status of cosmetic surgery - the concept of cosmetic
      surgery].

PMID- 1039400
TI  - [Importance of work in education - an educational methodology].

PMID- 1039401
TI  - [Plastic surgery in facial injuries].

PMID- 1039402
TI  - [Auricular reconstruction].

PMID- 1039403
TI  - [Plastic surgery in congenital abnormalities: cleft lip and cleft palate].

PMID- 1039404
TI  - [Plastic surgery in congenital anomalies: abnormalities of hands and feet].

PMID- 1039405
TI  - [Reconstruction surgery following excision of malignant tumors of the head and
      neck].

PMID- 1039406
TI  - [Basis and objectives of plastic surgery].

PMID- 1039408
TI  - [Medicine and human rights. A discussion].

PMID- 1039407
TI  - [Active communication in nursing - a future problem in clinical nursing].

PMID- 1039409
TI  - [Introduction to clinical training in nursing - The theory of clinical training
      based on personal experiences].

PMID- 1039410
TI  - [Nursing study as an independent academic entity].

PMID- 1039412
TI  - [A 5-day week system in the 3-year nursing course].

PMID- 1039411
TI  - [Nursing students' opinions on the method of clinical training. (I). On the
      educational evaluation].

PMID- 1039413
TI  - [A trial in clinical training in nursing. I. An inovation in clinical training at
      our school].

PMID- 1039414
TI  - [Emergence of positive nursing approach from the dark ages of nursing in modern
      Japan].

PMID- 1039415
TI  - [Methodological problems in nursing - nursing as an independent entity in medical
      care].

PMID- 1039416
TI  - [Physicians as patients].

PMID- 1039417
TI  - [Nursing study as an academic entity. II. Scientific theory].

PMID- 1039418
TI  - [Improved clinical training of nursing students. (2). Reevaluation of educational
      measurements].

PMID- 1039419
TI  - [Report by the Committee on Nursing Education of the Japan Nursing Association
      (9). Organization and management of nursing schools. (1). A survey of 445
      schools].

PMID- 1039421
TI  - [Discussion: professional nursing education and the educational format].

PMID- 1039420
TI  - [A trial in clinical nursing trainig. II. A basic training].

PMID- 1039422
TI  - [Leadership experiences for senior students].

PMID- 1039423
TI  - [Nursing study as an academic entity. III. My concept of medicine].

PMID- 1039424
TI  - [Structured system and evaluation in teaching].

PMID- 1039425
TI  - [Report by the Committee on Nursing Education of the Japan Nursing Association.
      9. Organization and management of nursing schools. 2. A survey of 445 schools].

PMID- 1039426
TI  - [A trial in clinical nursing training. III. Classroom instruction in clinical
      nursing].

PMID- 1039427
TI  - [Search of unknown nursing literature (1)].

PMID- 1039428
TI  - [Comparative study of activities of graduates of junior nursing colleges and
      various 3-year nursing schools].

PMID- 1039429
TI  - [SMON and SMON patients. The theoretical basis of patients' organizations].

PMID- 1039430
TI  - [Rehabilitation nursing of a patient with cerebral apoplexy - a study on
      promoting self-reliance in daily activities].

PMID- 1039432
TI  - [Need for nursing assistance for a patient with progressive muscular dystrophy
      being treated at home - a case study].

PMID- 1039431
TI  - [Report on public health nursing activities at the Kitasato University Hospital.
      (1)].

PMID- 1039433
TI  - [Evaluation of the health of women in an agricultural community].

PMID- 1039434
TI  - [Follow-up of at-risk patients spotted at the mass screening of young infants - a
      follow-up report with special reference to their mental development].

PMID- 1039435
TI  - [Case of encephalomalacia untreated for 4 months since its onset].

PMID- 1039436
TI  - [Theory of health in nursing (1)].

PMID- 1039437
TI  - [Prevention of congenital hip dislocation].

PMID- 1039438
TI  - [The welfare system and patients with refractory diseases].

PMID- 1039439
TI  - [SMON and SMON patients. The process of formation of patients' organizations].

PMID- 1039440
TI  - [Public health nursing education: comprehensive nursing training, a personal
      experience].

PMID- 1039441
TI  - [Public health nursing education: training helpful for understanding the patient,
      a personal experience].

PMID- 1039442
TI  - [Public health nursing education; a personal experience].

PMID- 1039443
TI  - [Public health nursing education: a lack of comprehensive training, a personal
      experience].

PMID- 1039444
TI  - [Public health nursing education: a lack of practical application, a personal
      experience].

PMID- 1039445
TI  - [Public health nursing education: a tendency towards disregard for real life in
      clinical training, a personal experience].

PMID- 1039446
TI  - [Intention and results of innovations in the curriculum for public health nursing
      education].

PMID- 1039447
TI  - [Discussion: redefinition of nursing activities. 4. Illustration with the case
      study of encephalomalacia untreated for 4 months (presented in the previous
      issue)].

PMID- 1039448
TI  - [Theory of health in nursing. (2)].

PMID- 1039449
TI  - [Psychological and social characteristics of patients with refractory diseases
      and their families (1). Keypoints in observation].

PMID- 1039450
TI  - [An organization of patients with myasthenia gravis].

PMID- 1039451
TI  - [Status of an undefined liver disease clustering in Yatsuka Cho, Shimane Pref.
      (2). An observation through the State Health Insurance records].

PMID- 1039452
TI  - [Health instruction of local patients following discharge from the hospital -
      pediatric patients].

PMID- 1039453
TI  - [Discussion: significance of public health nursing education in modern society].

PMID- 1039454
TI  - [Redefinition of nursing activities. 5. A discussion in relation to the case,
      left untreated for 4 months, with a young diagnosis of encephalomalacia
      (presented in Vol. 31, No. 2). 2].

PMID- 1039455
TI  - [Theory of health in nursing. (3)].

PMID- 1039456
TI  - [Patients with refractory diseases, cared for at home, and their families. 3. The
      patient, psychology of family members and their social characteristics. (2). Case
      studies].

PMID- 1039457
TI  - [Counseling of a school-age child with nephrosis and a history of repeated
      hospitalization].

PMID- 1039458
TI  - [Public health nursing activities in urban public health clinics - maternal and
      child health care].

PMID- 1039459
TI  - Editorial: A bright future for OB-GYN.

PMID- 1039460
TI  - The premature infant's reflex behaviors: effect on the maternal-child
      relationship.

PMID- 1039461
TI  - Indications of an unhealthy relationship between parents and premature infant.

PMID- 1039462
TI  - Two mothers' reactions to the deaths of their premature infants.

PMID- 1039463
TI  - Influences on sexual adaptation to mastectomy.

PMID- 1039464
TI  - Titrating with intravenous oxytocins.

PMID- 1039465
TI  - Making a good thing better: the regionalization of neonatal intensive care units.

PMID- 1039466
TI  - Letters: Whatever happened to prepared childbirth?

PMID- 1039467
TI  - [Prevention of iatrogenic incidents, an approach toward safer nursing].

PMID- 1039468
TI  - [Human services beyond the professional definition of nursing].

PMID- 1039469
TI  - [A new nursing seminar: Pediatrics. An independent personality of a child. A
      nursing action with understanding of the developing body and mind].

PMID- 1039470
TI  - [A new nursing seminar: Pediatric. Decision making in various nursing
      situations].

PMID- 1039471
TI  - [Questions and answers in pediatric nursing. Accurate advice to mothers with
      infants].

PMID- 1039472
TI  - [Nursing report. Nursing and rehabilitation of patients with patellar fractures].

PMID- 1039473
TI  - [On the degree-granting course in nursing].

PMID- 1039474
TI  - [Life science: medicine and man. Establishment and development of the society of
      medical philosophy (its impact on Japanese medicine)].

PMID- 1039475
TI  - [Nurse-patient interactions. I. The role of nursing].

PMID- 1039477
TI  - [Theory of nursing].

PMID- 1039476
TI  - [Advice for nursing students: the psychological aspect of nursing].

PMID- 1039478
TI  - [The language and communication].

PMID- 1039479
TI  - [Japanese characters used in chemical terminology].

PMID- 1039481
TI  - [On the degree-granting course in nursing].

PMID- 1039480
TI  - [The modern social structure and dehumanization: a need for a more humane
      attitude in the modern society].

PMID- 1039482
TI  - [Nursing report. Nursing of a patient with cerebral apoplexy].

PMID- 1039484
TI  - [Nursing seminar: nutrition].

PMID- 1039483
TI  - [Nurse-patient interactions].

PMID- 1039485
TI  - [New nursing seminar: nutrition. Questions and answers].

PMID- 1039486
TI  - [New nursing seminar: nutrition. Questions on the relationship between excessive
      sodium chloride intake and diseases].

PMID- 1039487
TI  - [Reflections on nursing: reevaluation of nursing approach].

PMID- 1039488
TI  - [The concept of atoms and atomic weights].

PMID- 1039489
TI  - [Concepts of life and social interactions expressed by young Japanese. A
      comparison with survey results conducted in various countries in the world].

PMID- 1039490
TI  - [On the advanced-degree-awarding nursing course for the practical nurse].

PMID- 1039491
TI  - [Nurses' opinions; roles of the nurse and of the housewife].

PMID- 1039492
TI  - [Nursing reports: practical application of basic nursing training].

PMID- 1039494
TI  - [New nursing seminar: anatomical physiology].

PMID- 1039493
TI  - [Discussion: the role of nursing - a dependable nursing service and its role in
      improving medical care in Japan].

PMID- 1039495
TI  - [New nursing seminar: anatomical physiology (questions and answers)].

PMID- 1039496
TI  - [Reflections on nursing: comprehension of the philosophy of nursing].

PMID- 1039497
TI  - [The origins of the names of elements].

PMID- 1039498
TI  - [Dissatisfaction with society and politics among Japanese youths. Results of the
      world-wide survey on youth' attitudes].

PMID- 1039499
TI  - [On the degree-awarding nursing course for practical nurses. Advice for
      candidates for evening courses].

PMID- 1039500
TI  - [Nursing report: rehabilitation and nursing of a patient with encephalomalacia].

PMID- 1039501
TI  - Adolescent pregnancy: the need for new policies and new programs.

PMID- 1039502
TI  - School-age parents. Models of comprehensive service - hospital-based.

PMID- 1039503
TI  - School-age parents. Models of comprehensive service - regular school-based.

PMID- 1039504
TI  - School-age parents. Models of comprehensive service - special school-based.

PMID- 1039506
TI  - Counseling services for school-age pregnant girls.

PMID- 1039505
TI  - The role of the grandmother in adolescent pregnancy and parenting.

PMID- 1039508
TI  - Education for parenthood and school-age parents.

PMID- 1039507
TI  - The unmarried father revisited.

PMID- 1039509
TI  - Appraising programs for school-age parents.

PMID- 1039510
TI  - Autonomy concerns of a child on dialysis.

PMID- 1039511
TI  - Responses of a twelve month old girl to physical restraint during
      hospitalization.

PMID- 1039512
TI  - Changing concepts of death in a child with sickle cell disease.

PMID- 1039513
TI  - The separation-individuation process in same-sex twins: a review of the
      literature.

PMID- 1039514
TI  - A primipara's feelings on the second post-partal day.

PMID- 1039515
TI  - Transitions in motherhood.

PMID- 1039516
TI  - Oedipal concerns of hospitalized preschool girls.

PMID- 1039517
TI  - Letters of a mother in mourning.

PMID- 1039518
TI  - The nursing process in the care of a hostile, pregnant adolescent.

PMID- 1039520
TI  - The health centre--a team approach to health care delivery.

PMID- 1039519
TI  - Nurses and their unions.

PMID- 1039521
TI  - Editorial: Criteria in assessing nursing staff needs.

PMID- 1039522
TI  - The role of the nurse in Australia.

PMID- 1039523
TI  - A member's feelings on current trends.

PMID- 1039524
TI  - o-Nitrophenyl-beta-D-galactopyranoside 6-phosphate.

PMID- 1039526
TI  - Temperature taking: ritualistic or rational routine?

PMID- 1039525
TI  - Quality of educational programs--whose responsibility?

PMID- 1039527
TI  - Editorial: "Henny Penny, the sky is falling!".

PMID- 1039528
TI  - PSRO: a challenge and opportunity for nursing.

PMID- 1039529
TI  - Nursing and the quality of life. Responsibility for environmental quality.

PMID- 1039530
TI  - Ecology, the nurse and health care.

PMID- 1039531
TI  - If you believe in it, stay with it.

PMID- 1039532
TI  - The changing pattern of community care.

PMID- 1039533
TI  - Guidelines for teachers of parentcraft and relaxation. 5. The new arrival.

PMID- 1039535
TI  - Neonatal bathing technique.

PMID- 1039534
TI  - Midwife tutor courses in Surrey University.

PMID- 1039536
TI  - The midwifery profession in Switzerland.

PMID- 1039537
TI  - Male midwives--a feasible prospect?

PMID- 1039538
TI  - Case study: essential hypertension in pregnancy.

PMID- 1039539
TI  - Some aspects of antibacterial therapy.

PMID- 1039540
TI  - Jane and Sara were old and helpless. Who would stand up for them?

PMID- 1039541
TI  - Blood pressure readings; getting them quickly on an infant.

PMID- 1039542
TI  - Miss Pinet knew?

PMID- 1039543
TI  - What every nurse should know about EKGs. Part 1.

PMID- 1039544
TI  - When to anticipate septic shock.

PMID- 1039545
TI  - Ambulatory nursing. 18 ways to live with asthma.

PMID- 1039546
TI  - Questions about copper contraceptives.

PMID- 1039547
TI  - Bronchoscope's benefits.

PMID- 1039548
TI  - How to enrich your management skills.

PMID- 1039549
TI  - Is I.V. therapy the specialty for you?

PMID- 1039550
TI  - Ted can only blink his eyes... still we communicate.

PMID- 1039551
TI  - Cancer quackery: what can you do about it?

PMID- 1039552
TI  - The child with sickle cell anemia. What his parents need to know.

PMID- 1039553
TI  - What every nurse should know about EKGs. Part 2.

PMID- 1039554
TI  - Burns: breaking the anger-despair cycle.

PMID- 1039555
TI  - Isolation: precise procedures for better protection.

PMID- 1039556
TI  - Maintaining sexuality after spinal cord injury.

PMID- 1039557
TI  - New drugs, 1974.

PMID- 1039558
TI  - SMA-12 (sequential multiple analysis); here's one way to interpret it.

PMID- 1039559
TI  - Working conditions. How do yours compare with other nurses?

PMID- 1039560
TI  - Our affection for Mrs. Johns was hindering our nursing care.

PMID- 1039561
TI  - What every nurse should know about EKGs. Part 3.

PMID- 1039562
TI  - Ravages of rheumatoid arthritis; rehabilitating both body and spirit. Nursing
      grand rounds.

PMID- 1039563
TI  - Insight into the delicate art of eye care.

PMID- 1039564
TI  - Was Terry dead?

PMID- 1039565
TI  - Cerebral arteriosclerosis.

PMID- 1039566
TI  - Getting along better with those aides.

PMID- 1039567
TI  - Glucose tolerance test: how you can make it more reliable.

PMID- 1039568
TI  - Devising a care plan you can really use.

PMID- 1039569
TI  - The choice.

PMID- 1039570
TI  - The hidden alcoholic: a nursing dilemma.

PMID- 1039571
TI  - What every nurse should know about EKGs. Part 4: ventricular arrhythmias.

PMID- 1039572
TI  - Renal failure and peritoneal dialysis.

PMID- 1039573
TI  - Summertime care for kids. Some helpful hints for nurses in ambulatory pediatric
      settings.

PMID- 1039574
TI  - Geriatric care; let's make it more that physical care.

PMID- 1039575
TI  - The varied symptoms of dysautonomia.

PMID- 1039576
TI  - Removing contact lenses.

PMID- 1039577
TI  - How a group can help you solve your problems.

PMID- 1039578
TI  - Cost of accidents.

PMID- 1039579
TI  - OH in Europe--2 France.

PMID- 1039580
TI  - Hazards of welding.

PMID- 1039581
TI  - Discipline and unfair dismissal.

PMID- 1039582
TI  - Personal protection.

PMID- 1039583
TI  - Employees' involvement in health and safety at work.

PMID- 1039584
TI  - A duty of reasonable care.

PMID- 1039585
TI  - Where does the OH nurse fit in?

PMID- 1039586
TI  - Emphasis on consultation.

PMID- 1039587
TI  - Recruiting on OH nurse.

PMID- 1039589
TI  - OH in Europe--5. Spain.

PMID- 1039588
TI  - The safety policy.

PMID- 1039590
TI  - Recognising mental disorder.

PMID- 1039591
TI  - Ionising radiations.

PMID- 1039592
TI  - OH in Europe--6. Comparisons.

PMID- 1039593
TI  - Care of eyes in 1975.

PMID- 1039594
TI  - Health hazards in compressed air.

PMID- 1039595
TI  - The limitations of TLVs.

PMID- 1039596
TI  - Editorial: Program for the recognition of the orthopedic nurse specialist.

PMID- 1039597
TI  - Orthopedic nurses make thorough assessments of orthopedic patients.

PMID- 1039598
TI  - Nursing care of the patient with a cervical spine injury.

PMID- 1039599
TI  - Guidelines for pediatric-orthopedic nursing history.

PMID- 1039600
TI  - Stacy's story.

PMID- 1039601
TI  - Articulation of health occupations programs: career mobility in Oklahoma.
      Highschool - practical nursing - associate degree.

PMID- 1039602
TI  - Developmental symbiosis.

PMID- 1039603
TI  - Disturbances in object relations in a chronic schizophrenic patient.

PMID- 1039604
TI  - Poetry programs in mental hospitals.

PMID- 1039605
TI  - Movement therapy with an autistic boy.

PMID- 1039606
TI  - The archetype of death and renewal in "I never promised you a rose garden".

PMID- 1039607
TI  - Behavior modification and the nursing process.

PMID- 1039608
TI  - Behavior modification: changing hyperactive behavior in a children's group.

PMID- 1039609
TI  - "The use of statistics in research".

PMID- 1039610
TI  - Nursing care study: secondary infertility--myomectomy/salpingostomies/Gilliams
      suspension.

PMID- 1039611
TI  - Psychosocial aspects of the nursing care of patients.

PMID- 1039612
TI  - The problem of deafness in children.

PMID- 1039613
TI  - Philosophy and objectives; their place in the nursing profession.

PMID- 1039614
TI  - "This I believe about student nurse evaluation".

PMID- 1039615
TI  - A patient care study on retinoblastoma.

PMID- 1039616
TI  - Proposed decree on abortion and nurses' role.

PMID- 1039617
TI  - The hopes and aspirations of a Nigerian student nurse.

PMID- 1039619
TI  - Doctor/nurse relationship: past, present and future.

PMID- 1039618
TI  - Nursing staff development and performance review.

PMID- 1039620
TI  - "The use of psychology in teaching".

PMID- 1039621
TI  - Men and the nursing profession in Nigeria.

PMID- 1039622
TI  - The use and abuse of a curricular model: an evaluative study of one C.E.G.E.P.'s
      nursing programme in Quebec.

PMID- 1039623
TI  - Financial assistance for nursing research--past and present.

PMID- 1039624
TI  - 8-4 research. Part II: DESIGNING NURSING RESEARCH--EIGHT POINTs of encounter.
AB  - In a two-part series, a proposal for research which integrates practical,
      technical, and political judgment is presented. Such research is called 8-4
      research and is opposed to pseudotechnical research. 8-4 research is discussed as
      an advance over more current nursing research preoccupations. In Part I it is
      proposed that nursing research should be considered in terms of payoff not merely
      promise for nursing, that 8-4 research is a suitable paradigm for all nursing
      research, and that nursing research is a suitable preoccupation for any and all
      nursing personnel. In Part II eight points of encounter--as between 8-4 research
      and pseudotechnical research-pertinent to designing nursing research are given. A
      conception of design is proposed that displays the role of conation, drive, or
      intent in any designed research.

PMID- 1039625
TI  - The special nurse research fellow: characteristics and recent trends.

PMID- 1039626
TI  - The methodology of historical research: a brief introduction.

PMID- 1039627
TI  - Research for a practice professional.
AB  - Research for any practice profession necessarily deals with professional arts and
      skills, with the base of knowledge underlying the practice field, and with the
      initial and continuing education of the professional. Recent developments and
      activities in the above areas are discussed, including growth in the investigator
      pool and studies that deal with the process and outcomes of nursing care.

PMID- 1039628
TI  - Comparison of Methods for evaluating patient response to nursing care.
AB  - Prenatal patients (chosen because the staff wished to know the patients attitudes
      toward their care and because on the health-illness continuum they were well and
      not dependent on staff for their daily needs) were asked to evaluate their
      obstetric care by means of a questionnaire and an interview. Of 191
      questionnaires distributed in the obstetric clinic of a large university medical
      center, 79 completed forms were returned and 39 interviews were done, using the
      format of the questionnaires. The interviews were conducted from the clinic by a
      person not on the clinic staff. Overall results showed no significant difference
      in patient responses between interview or questionnaire. The study revealed that
      the patients generally were satisfied with their care but that certain areas
      needed improvement.

PMID- 1039630
TI  - Letter: Portrait of a researcher: some reflections.

PMID- 1039629
TI  - Nursing students' opinions about acupuncture and Chinese medicine.
AB  - Eighty senior nursing students at the University of San Francisco (USF) were
      divided at random into four groups of 20. Two groups were pretested on their
      knowledge of acupuncture and Chinese medicine. One week later a 50-minute class
      in acupuncture and Chinese medicine was given in a community health class to one
      of the two pretexted groups and one of the two untested groups. Following the
      class, the test was given to all four groups. Using the Solomon Four-Group design
      to measure effects of pretesting and the class content, significant differences
      were found between the groups on questions seeking differences, to confirm the
      first hypothesis that an increase in knowledge about acupuncture and Chinese
      medicine will accompany an increase in its acceptance as a healing tool and the
      desire to learn more about it. A t-test on the results of pre- and post- tests
      confirmed the second hypothesis that there will be no difference between groups
      in history or maturation from one week to the next.

PMID- 1039631
TI  - Each week more than half a million people seek help for foot problems.

PMID- 1039632
TI  - Blood transfusion therapy.

PMID- 1039633
TI  - Bed-wetting.

PMID- 1039635
TI  - From the patient's point of view.

PMID- 1039634
TI  - Heartbeat-the rhythm of life.

PMID- 1039636
TI  - Attitudes toward the dying patient.

PMID- 1039637
TI  - Tips on tonsillectomies.

PMID- 1039638
TI  - How to handle pyschological regression in patients.

PMID- 1039639
TI  - Poisonous plants where you least expect them.

PMID- 1039640
TI  - Improving nutrition for the elderly.

PMID- 1039641
TI  - Don't be a statistic.

PMID- 1039642
TI  - New opportunities for the dedicated LPN: home nursing.

PMID- 1039643
TI  - In-theatre equipment for safer patient care.

PMID- 1039644
TI  - Nursing functions and law in India.

PMID- 1039646
TI  - Hydrophobia: facts about rabies.

PMID- 1039645
TI  - Law relating to licensing, registration and practice of nursing.

PMID- 1039647
TI  - Nursing at cross roads: a world-wide perspective.

PMID- 1039649
TI  - Role of a nurse in psychiatric field.

PMID- 1039648
TI  - Red cross revolution in Haryana and Punjab.

PMID- 1039650
TI  - Diploma in psychiatric nursing at A.I.I.M.H. Bangalore.

PMID- 1039651
TI  - Nurse-patient relationship therapy in socializing chronic schizophrenic patients.

PMID- 1039652
TI  - Forms of communication.

PMID- 1039653
TI  - An end - and a beginning.

PMID- 1039654
TI  - The mechanism of communication.

PMID- 1039655
TI  - The role of women.

PMID- 1039657
TI  - Skills of communication.

PMID- 1039656
TI  - Status of women in India.

PMID- 1039658
TI  - On the social position of Indian women.

PMID- 1039659
TI  - Status of nursing in India.

PMID- 1039660
TI  - Health and safety at work.

PMID- 1039661
TI  - The nurse machine.

PMID- 1039662
TI  - Industry-based training for occupational health nurses.

PMID- 1039663
TI  - Using models in nurse education.

PMID- 1039664
TI  - Nursing in a mission hospital.

PMID- 1039666
TI  - A chance to care.

PMID- 1039665
TI  - Money problems of psychiatric patients.

PMID- 1039667
TI  - The qualities of nursing.

PMID- 1039668
TI  - The tragic omission.

PMID- 1039669
TI  - Everybody out!

PMID- 1039670
TI  - Carstairs believes in tomorrow.

PMID- 1039671
TI  - Waste not, want not.

PMID- 1039672
TI  - Nuffield Nursing Homes Trust.

PMID- 1039673
TI  - Is there a future for the registered clinical nurse teacher?

PMID- 1039675
TI  - The differential leucocyte count.

PMID- 1039674
TI  - Starch granuloma peritonitis.

PMID- 1039676
TI  - In hospital. 1. The adult patient's view.

PMID- 1039677
TI  - For sickness or for health?

PMID- 1039679
TI  - The occupational health service at the Middlesex Hospital, London.

PMID- 1039678
TI  - Breaking the bounds.

PMID- 1039680
TI  - Integration-an exercise in self-analysis.

PMID- 1039681
TI  - In hospital. 2. The outpatient's view.

PMID- 1039682
TI  - Planning and staffing an ENT unit.

PMID- 1039683
TI  - The right to live or die.

PMID- 1039684
TI  - My name is John...

PMID- 1039685
TI  - Ward reports-sense or nonsense?

PMID- 1039686
TI  - Postnatal depression.

PMID- 1039687
TI  - Second "Best buy".

PMID- 1039688
TI  - A symposium on the psychiatric nurse-therapist: a new form of clinical nurse
      specialist. From the Institute of Psychiatry, Maudsley Hospital, London.
      Introduction and overview.

PMID- 1039689
TI  - The training of nurse-therapists.

PMID- 1039690
TI  - Patient selection, treatment, and outcome.

PMID- 1039691
TI  - The secondment period.

PMID- 1039692
TI  - A nurse-therapist's viewpoint.

PMID- 1039693
TI  - Behavioural psychotherapy in a domiciliary setting.

PMID- 1039694
TI  - Nurse-therapists at work: six case studies. 1. Pigeon phobia.

PMID- 1039695
TI  - Nurse-therapists at work: six case studies. 2. Agoraphobia complicated by
      alcoholism.

PMID- 1039696
TI  - Nurse-therapists at work: six case studies. 3. Social phobia.

PMID- 1039697
TI  - Nurse-therapists at work: six case studies. 4. Obsessive-compulsive disorder.

PMID- 1039698
TI  - Nurse-therapists at work: six case studies. 6. Non-consummation of marriage.
      Treatment of vaginismus and agoraphobia in the female partner.

PMID- 1039699
TI  - Nurse-therapists at work: six case studies. 6. Sexual deviation in a young man.

PMID- 1039701
TI  - Private and state medicine--the parting of the ways.

PMID- 1039700
TI  - In hospital. 3. The child's view.

PMID- 1039702
TI  - Pay beds-opposition view.

PMID- 1039703
TI  - Glaucoma.

PMID- 1039704
TI  - Premalignant conditions and causes of skin cancer.

PMID- 1039705
TI  - Cancer research: a personal view of maintenance therapy to prevent recurrence.

PMID- 1039706
TI  - Family planning service in Manchester.

PMID- 1039707
TI  - Absenteeism-an occupational hazard.

PMID- 1039708
TI  - The changing world of geriatrics.

PMID- 1039709
TI  - In hospital. 4. The senior citizen's view.

PMID- 1039710
TI  - Unusual casualties. Life-saving advice.

PMID- 1039711
TI  - Learning while caring.

PMID- 1039712
TI  - Management matters. Table talk.

PMID- 1039713
TI  - Is breast feeding being discouraged?

PMID- 1039714
TI  - Patients on the assembly line.

PMID- 1039716
TI  - More than meets the eye.

PMID- 1039715
TI  - Nursing care study: paroxysmal tachycardia in a newborn baby.

PMID- 1039717
TI  - The Ockenden venture.

PMID- 1039718
TI  - Priorities for the mentally handicapped in the community.

PMID- 1039719
TI  - Stillbirths and the law.

PMID- 1039720
TI  - Managementitis.

PMID- 1039721
TI  - Training in urological patient care.

PMID- 1039722
TI  - Practical learning for psychiatric nurses.

PMID- 1039723
TI  - Community health nursing in Northern Canada.

PMID- 1039724
TI  - Seat belts and the courts.

PMID- 1039725
TI  - Monday afternoons.

PMID- 1039726
TI  - The uniform problem.

PMID- 1039727
TI  - Nursing care study: paraplegia due to spinal lesion.

PMID- 1039728
TI  - Dare to do our duty.

PMID- 1039729
TI  - A symposium on battered children.

PMID- 1039731
TI  - The battered child syndrome - nursing care.

PMID- 1039730
TI  - The battered child syndrome-some research findings.

PMID- 1039732
TI  - The battered child syndrome - detection and prevention.

PMID- 1039733
TI  - The battered child syndrome - the law.

PMID- 1039734
TI  - The West African student in Great Britain.

PMID- 1039735
TI  - Planning an orientation course.

PMID- 1039736
TI  - North Carolina Memorial Hospital.

PMID- 1039737
TI  - A mothers' group in Alperton.

PMID- 1039738
TI  - Planning for the underpriveleged.

PMID- 1039739
TI  - Management matters: computer madness.

PMID- 1039740
TI  - Editorial: Smoking and health.

PMID- 1039741
TI  - EEC directives on nursing--the final phase.

PMID- 1039742
TI  - The masks of depression.

PMID- 1039743
TI  - Prolapse of the rectum.

PMID- 1039744
TI  - Taking the misery out of work.

PMID- 1039745
TI  - Post office nursing: occupational health service.

PMID- 1039746
TI  - Post office nursing: a day in the life of...

PMID- 1039747
TI  - Dementia in the elderly.

PMID- 1039748
TI  - Buttons and bows.

PMID- 1039749
TI  - The nurse practitioner.

PMID- 1039750
TI  - Nursing care study: motor neurone disease.

PMID- 1039751
TI  - A health service for NZ and the nursing profession.

PMID- 1039752
TI  - Nurses' attitude to death and related matters.

PMID- 1039753
TI  - Intra-aortic counterpulsation in cardiogenic shock.

PMID- 1039754
TI  - [Good fortune and the task].

PMID- 1039755
TI  - [The nurse of the future].

PMID- 1039756
TI  - [Patient and the nurse].

PMID- 1039757
TI  - [Department problems as expressed by the instructors].

PMID- 1039758
TI  - [Protection and hygienic conditions in our occupation].

PMID- 1039759
TI  - [Treatment and prevention of genetic disease].

PMID- 1039760
TI  - [The fight against cancer in Poland].

PMID- 1039761
TI  - [Arterial diseases of the lower extremity].

PMID- 1039762
TI  - [5. Nursing staff].

PMID- 1039764
TI  - [Psychological aspects of nursing].

PMID- 1039763
TI  - [Evaluation, but what kind...].

PMID- 1039765
TI  - [In a Norwegian hospital].

PMID- 1039766
TI  - [Nursing the cancer patient].

PMID- 1039767
TI  - [Surgical erysipelas].

PMID- 1039769
TI  - [On... the place of nurses on the medical team].

PMID- 1039768
TI  - [Analysis of the chart].

PMID- 1039770
TI  - The single-parent family. 1.

PMID- 1039771
TI  - What way the future?

PMID- 1039773
TI  - Transition to the community.

PMID- 1039772
TI  - Psychodrama: developments and applications.

PMID- 1039774
TI  - The single-parent family. 2.

PMID- 1039776
TI  - A patient's view.

PMID- 1039775
TI  - The science of nursing.

PMID- 1039777
TI  - Medicines can kill.

PMID- 1039778
TI  - Consumer responsibilities and rights in the health service.

PMID- 1039779
TI  - Patient care study: multiple sclerosis.

PMID- 1039780
TI  - Management of a new diabetic patient in the home.

PMID- 1039781
TI  - Evaluation problems of short courses and a trial method.

PMID- 1039783
TI  - Night nursing in the community.

PMID- 1039782
TI  - Patient care study: determination to regain independence.

PMID- 1039784
TI  - Making life easier for the blind.

PMID- 1039785
TI  - The diving reflex--therapy for the runaway heart.

PMID- 1039786
TI  - Respiratory distress: surgery in the newborn.

PMID- 1039787
TI  - How to resuscitate the depressed newborn.

PMID- 1039788
TI  - A nurse's lesson in humanity from the ghetto.

PMID- 1039789
TI  - Bladder training for the chronically ill.

PMID- 1039790
TI  - Who says senile geriatric patients are untreatable?

PMID- 1039791
TI  - Malaria: coming home with mobile Americans.

PMID- 1039792
TI  - Preventing drug toxicity in renal failure.

PMID- 1039793
TI  - Managing your money. Want a bargain? Try the outlet stores.

PMID- 1039794
TI  - The cardiac team: smoothing the recovery process.

PMID- 1039796
TI  - Sequelae of the addict's septic technique.

PMID- 1039795
TI  - I.M. lidocaine injections for myocardial infarction.

PMID- 1039797
TI  - The cigarette smoker: a greater anesthesia risk.

PMID- 1039798
TI  - The transformation of the ED nurse. Part 1. Learning to take the trauma of
      triage.

PMID- 1039799
TI  - Retarde children: they can't say where it hurts.

PMID- 1039800
TI  - Will Congress declare independence for nurses?

PMID- 1039801
TI  - Helping the alcoholic cope with...sobriety.

PMID- 1039803
TI  - Putting the brakes on car insurance costs.

PMID- 1039802
TI  - Don't underrate those clinical conferences!

PMID- 1039804
TI  - Research question: are student nurses realistic about the profession?

PMID- 1039805
TI  - Continuing nursing education: independent and dependent.

PMID- 1039806
TI  - [Psychiatric nursing in South Africa; an overview].

PMID- 1039807
TI  - Psychiatry.

PMID- 1039808
TI  - The potential for growth in aged mentally retarded patients.

PMID- 1039809
TI  - [The role of the psychiatric nurse in the community].

PMID- 1039810
TI  - Community psychiatry.

PMID- 1039812
TI  - [Social service in state mental hospitals].

PMID- 1039811
TI  - The acute psychiatric unit in a general hospital; with special reference to
      Groote Schuur.

PMID- 1039813
TI  - [Mental health legislation and the nurse].

PMID- 1039814
TI  - Learning problems in the young child. Tara, the H. Moross Centre. Child guidance
      clinic aspects.

PMID- 1039815
TI  - Fire safety in hospitals.

PMID- 1039816
TI  - [Wound care].

PMID- 1039817
TI  - [Environmental protection - nursing perspective].

PMID- 1039818
TI  - Learning problems in the young child. Tara, The H. Moross Centre. Child guidance
      clinic aspects.

PMID- 1039820
TI  - The meaning of care for young children in institutions for the mentally retarded.

PMID- 1039819
TI  - Australia antigen.

PMID- 1039821
TI  - Why the "Nursing Assistant"?

PMID- 1039823
TI  - Auditing of nursing care plans.

PMID- 1039822
TI  - Continuing education in nursing.

PMID- 1039824
TI  - Supervisor overseas: mental subnormality nursing.

PMID- 1039825
TI  - The playscript method of developing administrative procedures.

PMID- 1039826
TI  - Law for the nurse supervisor; the employee health service nurse.

PMID- 1039827
TI  - Editorial: Nursing's internal battle of the sexes.

PMID- 1039828
TI  - The art and science of supervision.

PMID- 1039829
TI  - [The nurse in our society].

PMID- 1039830
TI  - [The treatment of Parkinson's disease].

PMID- 1039831
TI  - [American course in enterostomal therapy and various remarks about this
      procedure].

PMID- 1039832
TI  - [The public health nurse in Iceland works under diverse conditions].

PMID- 1039833
TI  - [Nurse in Greenland's outland].

PMID- 1039834
TI  - The dilemma of the Victorian Infant Welfare Sisters.

PMID- 1039835
TI  - The stroke nurse clinician.

PMID- 1039836
TI  - Research: its dissemination and utilization in nursing practice.

PMID- 1039837
TI  - Infection control nurse; clinical specialist.

PMID- 1039838
TI  - New horizons in nursing.

PMID- 1039839
TI  - Tutor's responsibility for quality patient care.

PMID- 1039840
TI  - Sweet mystery of life.

PMID- 1039841
TI  - To catch up, keep up and forge ahead.

PMID- 1039842
TI  - The nurse in personnel.

PMID- 1039843
TI  - Professional obligations with effective rewards.

PMID- 1039844
TI  - New dimensions in nursing.

PMID- 1039845
TI  - Rehabilitation medicine.

PMID- 1039846
TI  - Rehabilitation nursing is nursing.

PMID- 1039847
TI  - The rehabilitation counselor: another factor in total patient care.

PMID- 1039848
TI  - The middle years: the sexually active middle adult.

PMID- 1039849
TI  - The change of life.

PMID- 1039850
TI  - The full life.

PMID- 1039851
TI  - The middle years: living sensibly.

PMID- 1039852
TI  - The middle years: coping with chronic illness.

PMID- 1039853
TI  - The middle years: the mid-stage woman.

PMID- 1039854
TI  - A faculty member reflects.

PMID- 1039855
TI  - Is gold a feasible investment?

PMID- 1039856
TI  - Students' rights.

PMID- 1039857
TI  - Cerebellar stimulation: pacing the brain.

PMID- 1039858
TI  - Multidisciplinary retrospective patient care audit.

PMID- 1039859
TI  - External counter-pulsation for cardiogenic shock.

PMID- 1039860
TI  - Separation anxiety: a personal experience.

PMID- 1039861
TI  - Providing experience in physical assessment for students in basic programs.

PMID- 1039862
TI  - Phaco-emulsification of cataracts.

PMID- 1039863
TI  - A toddler with a malabsorption syndrome.

PMID- 1039864
TI  - Janie remembered.

PMID- 1039865
TI  - Hot packs for morning joint stiffness.

PMID- 1039866
TI  - The middle years: a time of change.

PMID- 1039867
TI  - The middle years: emotional tasks of the middle adult.

PMID- 1039868
TI  - Fear is not enough.

PMID- 1039869
TI  - Summer clinical experience for nursing students.

PMID- 1039870
TI  - Is "nice" nurse concealing passive aggression?

PMID- 1039871
TI  - Guest editorial: OR nurse without peer in her domain.

PMID- 1039872
TI  - Rationale for asepsis standards.

PMID- 1039873
TI  - Rationale for OR attire standards.

PMID- 1039874
TI  - AORN standards for OR sanitation.

PMID- 1039876
TI  - Sensitivity training viable tool in OR.

PMID- 1039875
TI  - AORN standards for OR sanitation.

PMID- 1039877
TI  - Excellence in use, choice of technology.

PMID- 1039878
TI  - Progress in OR nursing practice.

PMID- 1039879
TI  - The pursuit of excellence as a professional goal.

PMID- 1039881
TI  - OR nurse as primary care agent.

PMID- 1039880
TI  - Nursing practice act revisions.

PMID- 1039882
TI  - Editorial: On certification, Board listens to members' concerns.

PMID- 1039883
TI  - What determines nursing vs medical diagnosis?

PMID- 1039884
TI  - Do strikes in hospitals justify goals?

PMID- 1039885
TI  - NLN position on licensure.

PMID- 1039887
TI  - The RN as negotiator.

PMID- 1039886
TI  - Body's response to infection.

PMID- 1039888
TI  - Anesthetic control for oral surgery.

PMID- 1039889
TI  - Therapeutic, cosmetic effects of oral surgery.

PMID- 1039890
TI  - Riders of the cyclone.

PMID- 1039891
TI  - The family practice nurse.

PMID- 1039892
TI  - Milestone in education.

PMID- 1039893
TI  - Education: grappling with a dragon.

PMID- 1039894
TI  - Vitamin D. II.

PMID- 1039895
TI  - Life times: many the hearts ...

PMID- 1039896
TI  - The future of nursing in Australia: an outsider's realities and strategies.

PMID- 1039897
TI  - Is hospital a dangerous place to work in?

PMID- 1039898
TI  - The class of '74.

PMID- 1039899
TI  - The profession.

PMID- 1039900
TI  - Vitamins - friend or foe?

PMID- 1039901
TI  - Knock and it shall be opened...

PMID- 1039902
TI  - Training for crisis therapy.

PMID- 1039903
TI  - Cultural relativism and outback nursing.

PMID- 1039904
TI  - Home and hospital: an analysis of a bridging exercise.

PMID- 1039905
TI  - Team nursing--why?

PMID- 1039906
TI  - Editorial: Beware of something for nothing (old Australian proverb).

PMID- 1039907
TI  - Pharmacokinetics and efficacy of trimethoprim-sulfamethoxazole in the treatment
      of gastroenteritis in children.
AB  - In vitro studies indicates that the constitutents of the drug combination co
      trimoxazole are synergistic against Salmonella and effective against shigella
      isolated from children ill with gastroenteritis. The drug is well absorbed in
      children with gastroenteritis due to a variety of causes and is distributed,
      excreted and metabolized in a manner similar to that seen in normal adult
      volunteers. The drug is tolerated well by children with gastroenteritis even in
      very high dosages. Despite its in vitro and pharmacokinetic advantages, co
      trimoxazole was not any more efficient than any other durg or no therapy in the
      treatment of salmonella gastroenteritis; it seems to have a role, however, in the
      treatment of typhoid fever and may be life-saving in patients infected with
      ampicillin- and chloramphenical-resistant strains. It is also effective in the
      treatment of shigella gastroenteritis and is recommended where ampicillin
      resistant strains are encountered. Its potential usefulenss for the treatment of
      other bacterial causes of gastroenteritis in children must be evaluated by
      further controlled therapeutic trials.

PMID- 1039908
TI  - Hypertension. Part I. detection and evaluation.

PMID- 1039909
TI  - Genetic control of wing disc development in  Drosophila.
AB  - In multicellular organisms morphogenesis results from organized cell
      proliferation and spatial cell differentiation.  A genetic approach to
      development has the two-fold task of explaining how the genetic information is
      selected and how it expresses itself in developmental operations.  The genetic
      and developmental analysis of morphogenetic mutants in Drosophila has thrown some
      light on both problems.  Experiments on genetic mosaics confirm the idea that the
      genetic information is expressed within the cell itself.  The behaviour of those
      morphogenetic mutants in mosaics suggests the existence of at least two classes
      of morphogenetic genes.  Genes of a first group (cyto-differentiation genes)
      would include those controlling cell behaviour relevant to morphogenesis and
      common to most developing systems: mitotic rate, mitotic orientation, cell
      recognition and cuticular differentiation.  Those of a second group (selector
      genes) seem to control developmental pathways and share several operational
      characteristics.  A functional scheme is advanced showing how selector genes may
      become activated and control development.  We postulate that inductor molecules
      interfere with the products of activator genes which are selector specific.  In
      this way signals extrinsic to the genome become translated into genetic ones. 
      The activation, or repression, of selector genes occurs once in development and
      remains clonally irreversible.  This, possibly, is the genetic basis of a stable
      state of determination.  However, the products of these activated selector genes
      are required throughout subsequent development in order to maintain a certain
      pathway.  They may function by activating in turn the corresponding
      cytodifferentiation genes leading to changes in developmental operations.

PMID- 1039910
TI  - Attmepts to analyse the biochemical basis of regional differences in animal eggs.
AB  - The microinjection of cell material or macromolecules into living cells is
      potentially useful for identifying cell components responsible for positional
      information.  Experiments with purified globin mRNA injected into frog oocytes
      and eggs show that macromolecules can retain their activity when injected into
      living cells.  Experiments with histones show that injected macromolecules can
      take up their normal intracellular location in living cells.  Attempts have been
      made to identify the molecules involved in regulating DNA synthesis, ribosomal
      RNA synthesis, and early developmental events by fractionating egg cytoplasm, and
      by rescuing maternal effect mutants.  The present state, and theoretical basis,
      of such experiments is discussed.

PMID- 1039911
TI  - Pattern specification in the insect embryo.
AB  - Specification of developmental pathways by specific determining substances
      prelocalized in the egg cytoplasm is duscussed using the so-called germ cell
      determinants as an example.  Some theoretical considerations speak against the
      assumption that in insects the various elements of the basic body plan are
      specified by a prelocalized mosaic of specific determinants.  Experimental
      evidence also points towards a largely epigenetic mode of pattern specification. 
      The process of axial pattern specification can be altered drastically by
      experiment: in some insects, tail ends may be formed in place of head parts and
      identical wequences of bocy segments may be specified two or even three times
      along the longitudinal egg axis.  The experimental results indicate that polarity
      and regional character of pattern elements formed are specified by one and the
      same influence, and that this influence can be shifted to or simulated in various
      other egg regions by transposition or elimination of egg components, or by UV
      irradiation.  Evidence obtained from several types of experiment in the
      chironomid midge Smittia points towards a key role for local metabolsim or energy
      charge in determination of cell polarity and in pattern specification.  A model
      for embryonic pattern specification involving differential reaction of cells to a
      system of longitudinal gradients, which was proposed in 1960, can in principle
      formally account for all results described.  Some striking coincidences of model
      and experimental results with Wolpert's concept of positional information are
      noted.  Finally it is pointed out that universality of mechansims for pattern
      specification is much more likely with respect to formal principles than at the
      level of their physiological realization.

PMID- 1039912
TI  - The development of neuronal connection patterns in the visual systems of insects.
AB  - The retina of the compound eye contains a patterned spatial array of receptor
      cell groups whose symmetry and component numerical constancy allow the unique
      identification of individual cells.  The axon connection patterns arising from
      the retina similarly are uniquely identifiable and relate by simple consistnet
      transpositons to the retinal position of their somata.  The coincidence of these
      features and the epidermal origin or retinula cells provides a model system for
      the developmental analysis of neural patterns.  It is known that the retina
      develops by a wave of determinative mitoses and subsequent cellular
      differentiation, transmitted inductively from a posteriorly situated
      differentiation centre, which passes over the prospective eye field independently
      of the growing axon connections with the optic lobe.  The ganglion cells of the
      optic lobe are similarly produced in a temporal sequence but their subsequent
      differentiation depends on centripetal innervation and proceeds as a wave
      initiated in the retina.  Axon growth between the retina and optic neuropiles
      occurs in this temporal sequence, appears largely non-exploratory and dependent
      on mechanical guidance.  By contrast, individual axon connections within the
      neuropile form probabilistically by extensive filopod explorations between cones.
      Both growth between and growth within the neuropile depend upon features in the
      pattern of retinal development which are discussed.

PMID- 1039913
TI  - Topography and topology in functional recovery of regenreated sensory and motor
      systems.
AB  - Motor and sensory nerves can re-establish coordinated movement and accurate
      sensation when they regrow into denervated tissues of some lower vertebrates. 
      Motor nerves achieve their end by a competitive process in which each motoneuron
      innervates many muscle fibres but, in the presence of many applicants, only those
      synapses from motoneurons most appropriate to a muscle cell, with respect to the
      original pattern of development, are retained in a functional state.  The
      discharge pattern of a motoneuron, determined by its connections with the network
      of central interneurons, is not sensitive to the location of the muscles in which
      the axon terminates, but the efficacy of transmission from the terminals is. 
      Sensory nerves re-establish their functional specificity as to receptor type by
      an inductive  process occurring at the terminals along with the cessation of
      growth.  However, in the case of cutaneous nerves they can terminate anywhere
      over the skin surface.  The return of correctly localized reflex behaviour
      therefore demands a restructuring of the central nervous system in response to
      local position-specific signals, presumably of developmental origin, that are
      supplied to the sensory nerves by the skin.  The re-arrangement of the central
      nervous connections made by the central processes of the sensory neurons probably
      uses the same competitive mechanism of enabling and disabling formed synaptic
      connections as is used in sorting out the correct site of functional termination
      of the peripheral processes of motoneurons.

PMID- 1039914
TI  - The structure and properties of a compartment border: the intersegmental boundary
      in Oncopeltus.
AB  - Garcia-Bellido et al. have described how groups of cells in developing Drosophila
      become subdivided into 'compartments'.  Cells within any compartment have rigid
      prospective fates such that, while their progeny may give rise to variable
      regions within a compartment, they can never generate cells in any other
      compartment.  Analysis of the position and shapes on clones allows definition of
      the compartment boundaries.  I report studies on a compartment boundary (likewise
      demonstrated by clonal analysis) in the hemipteran insects Oncopeltus and
      Rhodnius.  The advantage of this border is that it can easily be identified in
      the light and electron microscopes.  There is an abrupt change of cell shape at
      the border, which has been analysed by means of serial electron microscope
      sections.  The types of cell junctions at the border and elsewhere are compared
      and shown to have no qualitative differences.  The border is an effective barrier
      to the growth of peripheral sensory axons, although not apparently to dendrites. 
      The intersegmental boundary allows passage of information relating to cuticle
      deposition, wounding response, tracheolar movement and intercellular coupling. 
      Making wounds across the border leads to greater effects on polarity of epidermal
      cells than making similar wounds elsewhere on the tergites.

PMID- 1039916
TI  - Closing remarks: the genetic outlook.

PMID- 1039915
TI  - A molecular approach to retinotectal specificity.
AB  - An assay is described to examine the hypothesis that retinal neurons adhere
      preferentially to that part of the optic tectum near theri normal synaptic
      termini.  The method measures the adherence of isotopically labelled cell bodies
      from either the dorsal or ventral half of the neural retina of chick embryos to
      dorsal and ventral tectum halves.  When a labelled cell suspension is prepared
      from a dorsal half-retina, more cells adhere to the ventral half of the tectum. 
      When the cells are from the ventral part of the retina, more bind to the dorsal
      half of the tectum.  This preferential adhesion mimics the retinotectal
      projection found in vivo and supports an interpretation of neuronal specificity
      dependent on cell surface adhesive properties.  Molecular mokels are presented
      that utilize glycosyltransferases and their substrates as the basis for adhesive
      recognition.  Two of these models suggest that quantitative changes in the
      distribution of transferases and their substrates determine retinotectal
      specificity.  The third proposes qualitative variations in these molecules across
      the retina and tectum.

PMID- 1039917
TI  - Feather pattern development.
AB  - Experiments on skin development in amniotes have shown conclusively that the
      pattern of cutaneous appendages is determined by the dermis.  The following
      concept of feather pattern formation is proposed.  The diameter of feather
      rudiments and the dermal cell density inside the dermal feather condensations are
      genetically fixed, region-specific parameters.  The first feather rudiment is
      established along the middorsal line (in the lumbar region) as soon as a
      sufficient width of dense dermis is available.  This occurs at about 6 1/2 days
      in the chick embryo.  The next rudiments are formed in front of and behind the
      first one, within the longitudinal band of dense dermis.  They are laid down as
      close as possible to the first one, given rudiment diameter and dermal
      condensation cell density.  In other words, as they form, the middorsal rudiments
      are tangent circles.. Later they become separated from one another due to
      longitudinal growth.  As progressively more dense dermis becomes available to the
      sides of the middorsal row of rudiments, new rudiments are being laid down
      lateral to the middorsal row, in successive longitudinal rows, until, by 9 or 10
      days, all the available dense dermis has been used up.  Again, the rudiments in
      the lateral rows, given their diameter and dermal condensation cell density,
      develop as close as possible to those of the preceding row, i.e. tangentially to
      two neighbouring rudiments of the preceding row, thus generating a hexagonal
      pattern.

PMID- 1039918
TI  - Regeneration and duplication in imaginal discs.
AB  - When two complementary fragments of a Drosophila imaginal disc are cultured in
      adult abdomens before transfer to host larvae for metamorphosis, the usual result
      is that one of the two fragments regenerates the missing parts while the other
      fragment duplicates the anlagen already present.  To account for this it is
      proposed that in the disc there is a gradient of developmental capacity, by which
      new positional information can be generated from a cut surface only in the
      downward direction in the gradient, irrespective of the physical direction faced
      by the cut surface.  The same kind of behaviour is shown by other epimorphic
      systems, such as the regenerating appendages of amphibians and of hemmimetabolous
      insects, and the regenerating body segments of annelids.  The regeneration
      duplication rule has been shown to apply for thirteen different cuts in the wing
      disc, some across the proximodistal and others across the anteroposterior axis. 
      In both axes there is a reversal in the direction of regenerative ability at the
      approximate centre of the disc.  As an alternative to the hypothesis of
      orthogonal double gradients, it is proposed that the wing disc has multiple
      gradients of developmental capacity which radiate from the centre of the disc. 
      The location of this centre is known, and its properties are being studied.

PMID- 1039919
TI  - Morphogenesis of the vertebrate limb.
AB  - Pattern formation in both the developing and the regenerating vertebrate limb can
      be understood in terms of the assignment of positional values to cells.  The
      positional value may then control the selection of a course of
      cytodifferentiation as, say, muscle or cartilage.  It is proposed that the
      proximodistal coordinate of positional value is extablished by a mechanism based
      on autonomous change with time in a 'progress zone' at the tip of the limb bud. 
      The anteroposterior coordinate seems to be specified by a positional signal from
      an orgainzing region.  Only cells in the progress zone respond to this signal. 
      The change of character in the progress zone may be linked to cell division.  It
      seems that each skeletal rudiment may initially be the same length, corresponding
      to the amount of tissue that leaves the progress zone during one cell cycle.  The
      lengths on the skeletal elements are already specified shortly after exit from
      the progress zone, and are capable of very little regulation.  The positional
      value may determine the pregramme of later growth.  The relevance of the progress
      zone model to epimorphic regulation, and amphibian limb regeneration in
      particular, is discussed.

PMID- 1039920
TI  - [No more hunger: hunger never again!].

PMID- 1039921
TI  - Impotence as a practical problem.

PMID- 1039922
TI  - [Rectal carcinoma; preventive examinations in hospital and surgical practice].

PMID- 1039923
TI  - [The beginning of human life - embryology].

PMID- 1039924
TI  - [Asepsis and disposable syringes; a critical evaluation of technic and
      management].

PMID- 1039925
TI  - [Continued education for specialty nursing in psychiatry in the psychiatric
      clinic of the city hospital of the city of Stuttgart].

PMID- 1039926
TI  - [Experiences with disposable diapers].

PMID- 1039927
TI  - [Health significance of chemical poisons used in agriculture].

PMID- 1039928
TI  - [Tick-borne encephalitis. Clinical aspects and prevention].

PMID- 1039929
TI  - [Skin cancer].

PMID- 1039931
TI  - [Treatment of acute respiratory diseases and influenza].

PMID- 1039930
TI  - [Viral diseases of the skin].

PMID- 1039932
TI  - [Rupture of the symphysis during labor].

PMID- 1039933
TI  - [The year 1975--the International Year for Women].

PMID- 1039934
TI  - [The use of drugs during pregnancy].

PMID- 1039935
TI  - [Differential diagnosis of perforating gastric ulcer].

PMID- 1039936
TI  - [Teaching the population the basic aspects of rural health facilities].

PMID- 1039937
TI  - [Prevention of overheating and overcooling in persons working in the open air
      (material for discussion)].

PMID- 1039938
TI  - [Hemorrhagic fever with a renal syndrome].

PMID- 1039939
TI  - [Health characteristics of chemical poisons used in agriculture (chlororganic,
      phosphorus organic chemical poisons)].

PMID- 1039941
TI  - [Fractures of the distal aspect of the forearm bones].

PMID- 1039940
TI  - [Clinical aspects and differential diagnosis of food poisoning].

PMID- 1039942
TI  - [Risk, complications and their prevention in labor with breech presentation].

PMID- 1039943
TI  - [Prehospital first aid in trauma of the locomotor apparatus].

PMID- 1039944
TI  - [Health center--an important link in the protection of miners' health].

PMID- 1039945
TI  - [For parents about sex education of girls at home (material for discussion)].

PMID- 1039946
TI  - [Training of paramedical personnel in the problems of prevention poisoning with
      chemical poisons].

PMID- 1039947
TI  - [Ultrasonic surgery methods in traumatology].

PMID- 1039949
TI  - [Regulation for nurses].

PMID- 1039948
TI  - [Prevention and anti-epidemic measures in cholera].

PMID- 1039950
TI  - [Regulation for nurses].

PMID- 1039951
TI  - Models for midwifery clinical practice.

PMID- 1039952
TI  - Cognition and person perception in an aging population.

PMID- 1039953
TI  - Scholarship - a woman's perspective.

PMID- 1039954
TI  - An investigation of the sharing of common fears between mothers and their eleven
      year-old children in middle-class families.

PMID- 1039955
TI  - [Examination of a patient suffering from chronic arterial hypertension].

PMID- 1039956
TI  - [Prolonged-action medications].

PMID- 1039957
TI  - [Hypoglycemia].

PMID- 1039959
TI  - [Erythema nodosum].

PMID- 1039958
TI  - [Specimen collection and preservation of biological liquids].

PMID- 1039960
TI  - [Diagnosis of anemia].

PMID- 1039961
TI  - [Crohn's disease].

PMID- 1039962
TI  - [General review of vitamins].

PMID- 1039963
TI  - [Frank talk about sexuality].

PMID- 1039964
TI  - [The pregnant adolescent].

PMID- 1039965
TI  - [The director of nursing care as seen by herself].

PMID- 1039966
TI  - [The Clinic for health maintenance; is it a solution?].

PMID- 1039967
TI  - [Instructor-student relations influence nursing care].

PMID- 1039968
TI  - [Freezing mother's milk].

PMID- 1039969
TI  - [Continued education should be optional].

PMID- 1039970
TI  - [Sex customs in Zaire].

PMID- 1039971
TI  - [Management courses?].

PMID- 1039972
TI  - [Stoma dressings also cure decubitus ulcers].

PMID- 1039973
TI  - [Stp smoking without gaining weight is possible!].

PMID- 1039974
TI  - [Manager of a 1000 crafts].

PMID- 1039975
TI  - Editorials, review articles, and case reports.

PMID- 1039976
TI  - The use of intra-aortic belloon counterpulsation in the management of cardiogenic
      shock.

PMID- 1039977
TI  - Mortality of myocardial infarction treated in the coronary-care unit.

PMID- 1039978
TI  - Continuing evaluation of coronary care.
AB  - Continuing evaluation of coronary care is necessary to determine its present
      effectiveness and to establish direction in the effort to decrease mortality
      after myocardial infarction. Data have been collected on 157 consecutive patients
      diagnosed as having myocardial infarction who were admitted to the coronary-care
      unit at St. Joseph's Hospital and Medical Center, Phoenix, Ariz. The hospital is
      a teaching hospital with a 560-bed capacity. Data sheets were completed on each
      patient at the time of transfer from the coronary-care unit. The accumulated data
      were processed by a computer at the end of a 13-month period. The overall
      mortality for the group was 16.5 per cent. The factors which were found to have a
      significant effect on mortality were: (1) location of infarction, (2) presence of
      heart failure, (3) occurrence of cardiogenic shock, (4) age, and (5) the presence
      of intraventricular conduction defect. In 19 of the 26 deaths after myocardial
      infarction, the terminal event was associated with congestive heart failure,
      pulmonary edema, or cardiogenic shock. Three patients died of resistant
      arrhythmia, four of ventricular rupture. These figures indicate that arrhythmia
      is not a primary cause of death after myocardial infarction and that attention
      must also be directed to the early diagnosis and treatment of left ventricular
      failure if coronary care survival rates are to improve.

PMID- 1039979
TI  - Clinical evaluation of a new computerized arrhythmia monitoring system.
AB  - A study has been made of the accuracy of a computerized system of arrhythmia
      monitoring in the coronary-care unit of the Palo Alto Veterans Administration
      Hospital. The system provides beat-to-beat analysis of cardiac rhythm and QRS
      morphology and stores information for display of incidence of abnormalities and
      trend curves. The variables monitored by the system include: (1) heart rate, (2)
      early beats, (3) late beats, (4) abnormal QRS waveforms, and combinations of 2,
      3, and 4. Accuracy analysis was performed using a standard ECG trace with a
      simultaneous record of computer classification of each QRS complex on a dual
      channel recorder. Thirty-four patients with various cardiac arrhythmias were
      studied and 188,000 QRS complexes were evaluated. The number of true abnormal
      beats (abnormal in timing or waveform) recorded by the ECG was 12,194 out of
      188,000 or 6.5 per cent. Computer classification accuracy was as follows: false
      positives (computer diagnosis abnormal but ECG diagnosis normal), 0.10 per cent
      (191 complexes) of all complexes and 1.56 per cent of true positives. False
      negatives (computer diagnosis normal but ECG diagnosis abnormal), 0.70 per cent
      (84 complexes) of abnormal beats. Computer monitoring and analysis of seven
      variables in cardiac rhythm and QRS waveform abnormalities can be performed with
      a high degree of accuracy using a compact computer system suitable for intensive
      care units.

PMID- 1039980
TI  - Stress on the nurse and therapist in the intensive-care unit and the coronary
      care unit.

PMID- 1039981
TI  - As the patient views the intensive-care unit and the coronary-care unit.

PMID- 1039982
TI  - Adult respiratory distress syndrome.

PMID- 1039983
TI  - The electrocardiographic features of left ventricular "overload".

PMID- 1039984
TI  - Cardiac pacemakers. IV. Complications of pacing.

PMID- 1039985
TI  - A symposium on surgery for coronary artery disease. Pre-infarction syndrome-
      surgical indications.
AB  - Although the atherosclerotic process does not penetrate the coronary circulation
      at subendocardial levesl, the hemodynamic effects of coronary arterial narrowing
      occur at the endocardial and myocardial cellular levels. Theee resultant
      deprivation of blood supply to these tissue areas eventually leads to myocardial
      infarction. In certain clinical situations, a sudden increase in symptoms
      signifies and impending acute ischemic process. Three parameters have clinically
      been used to evaluate the changes that lead progressively to myocardial
      infarction: symptoms, electrocardiogram, and serum enzyme levels. The typical
      preinfarction patient experiences episodes of acute angina pectoris, sometimes
      intense and prolonged, and often unresponsive to nitroglycerin. Physical
      examination is usually not remarkable, serum enzyme levels are normal if tissue
      damage has not occurred, and the electrocardiogram is variable with pain. Th
      pathologic process in the preinfarction patient is frequently confined to the
      proximal arterial segment of one or more of the coronary arteries, usually in the
      form of a high-grade (in excess of 95 per cent) atherosclerotic lesion. This
      pathologic condition presents a satisfactory distal arterial segment suitable for
      bypass, and these patients are ideal candidates for urgent myocardial
      revascularization.

PMID- 1039986
TI  - Surgical correction of coronary arterial disease associated with lesions of the
      aorta ad its major branches.
AB  - When a candidate for aortocoronary bypass has an associated lesion of the aorta
      orone of its major branches, a single operation may be indicated for correction
      of both problems. Three typical cases illustrate the concept of the combined
      approach to surgical management of coronary arterial lesions and associated
      carotid arterial disease, abdominal aortic aneurysm, and superficial-femoral
      arterial disease. An aortocoronary bypass candidate with carotid stenosis may be
      in imminent danger of both myocardial infarction and stroke. The selection of the
      proper sequence of operations under these circumstances is extremely important
      because any form of hypotension might produce a stroke. Cardiopulmonary bypass
      usually results in at least a transient reduction of the systemic pressure which
      would further compromise the blood flow across the tight stenosis of the carotid
      artery. Therefore, we recommended repair of the carotid lesion before
      aortocoronary bypass is attempted in order to avoid the possibility of
      postoperative stroke. The combined presence of coronary arterial disease and
      abdominal aortic aneurysm is indication for operation, but resection of the
      aneurysm involves cross-clamping of the aorta, and subsequent changes in arterial
      pressure might impair the coronary circulation and lead to myocardial infarction.
      On the other hand, the systemic heparinization required for the establishment of
      cardiopulmonary bypass and arterial pressure changes could affect the integrity
      of aneurysm. Unless the abdominal aneurysm is expanding, however, we elect to
      perform coronay revascularization first, with resection and graft replacement of
      the aneurysm immediately after heparin reversal. Occlusive disease of the
      superficial femoral artery can be corrected immediately following aortocoronary
      bypass. Since the femoral and upper leg incisions have been performed, in certain
      cases it is convenient to complete the femoral popliteal bypass while the chest
      is being closed, thus saving a separate operation to correct the femoral
      occlusive disease.

PMID- 1039987
TI  - Visual inspection of the patient with cardiopulmonary disease.

PMID- 1039988
TI  - Comparison of A-V block due to acute myocardial infarction and chronic conduction
      system disease.

PMID- 1039989
TI  - Phasic aberrant ventricular conduction manifesting as right bundle branch block
      with left anterior hemiblock.

PMID- 1039990
TI  - Cardiac pacemakers: indications and complications.

PMID- 1039991
TI  - Radiation pneumonitis producing respiratory failure.

PMID- 1039993
TI  - Letter: Electrocardiographic changes associated with hyperkalemia.

PMID- 1039992
TI  - Peritonitis--old and new thoughts.
AB  - A review of the etiology, pathogenesis, pathophysiology, and clinical picture of
      peritonitis is presented. A regimen for treatment is outlined. Complications and
      newer methods of adjuvant therapy are discussed.

PMID- 1039994
TI  - Letter: Measurements of lateral wall pressures exerted by tracheostomy and
      endotracheal tube cuffs.

PMID- 1039995
TI  - American College of Sports Medicine: position statement on prevention of heat
      injuries during distance running.

PMID- 1039996
TI  - An osteopathically integrated approach to the whiplash complex.

PMID- 1039997
TI  - Primary angiosarcoma of the brain: report of a case.

PMID- 1039998
TI  - A comprehensive program of health care utilizing the team approach to the
      education of the patient with chronic obstructive pulmonary disease.

PMID- 1039999
TI  - Bronchofiberscopic examinations by pulmonary physicians: a review of 350 cases.

PMID- 1040000
TI  - Dental equilibration and osteopathy.

PMID- 1040001
TI  - Corrective procedures for disorders of the foot.

PMID- 1040002
TI  - The nurse and acute spinal injury.

PMID- 1040003
TI  - Presidential address.

PMID- 1040004
TI  - Technical note: a new flexible radiopaque silicone rubber aqueductal catheter.

PMID- 1040005
TI  - Dorsal column stimulator: nursing aspects.

PMID- 1040006
TI  - Microtechnical nursing in neurosurgery.

PMID- 1040007
TI  - Micro-surgical treatment of intracranial aneurysms.

PMID- 1040008
TI  - Nursing involvement with monitoring of ICP.

PMID- 1040009
TI  - Dorsal column stimulation.

PMID- 1040010
TI  - Nursing implications in the administration of urea.

PMID- 1040011
TI  - Abnormal respiratory patterns in the comatose patient caused by intracranial
      dysfunction.

PMID- 1040012
TI  - The why's and what's of private practice.

PMID- 1040013
TI  - Body rhythm effects on rotating work shifts.

PMID- 1040014
TI  - Patients' perception of care under team and primary nursing.

PMID- 1040015
TI  - Future shock invades nursing.

PMID- 1040017
TI  - The clinical specialist: from hospital, to clinic, to community.

PMID- 1040018
TI  - Institutional politics.

PMID- 1040016
TI  - The hospital setting and patient care outcomes. Part I.

PMID- 1040019
TI  - Nursing practice research: what's it all about?

PMID- 1040020
TI  - Staff development: what are the qualifications?

PMID- 1040021
TI  - Non-profit hospitals and the National Labor Relations Act--first issues.

PMID- 1040022
TI  - Tapping human resources.

PMID- 1040023
TI  - Nursing research priorities.

PMID- 1040024
TI  - The planning and evaluation of automated systems: a nurse's point of view.

PMID- 1040025
TI  - Management time: who's got the monkey?

PMID- 1040026
TI  - The modified work week for nursing staff on two pediatric units.

PMID- 1040027
TI  - Executive recruiters and the nursing service administrator.

PMID- 1040028
TI  - The advanced nursing practitioner: a dilemma for supervisors.

PMID- 1040029
TI  - Hospital involvement in community health care.

PMID- 1040030
TI  - Abdominal X-ray changes in kwashiorkor before and after barium.

PMID- 1040031
TI  - Prolonged breastfeeding as a birth spacing method.

PMID- 1040032
TI  - The use of the icterometer in assessing neonatal jaundice.

PMID- 1040033
TI  - Logical-flow diagrams in the training of health workers.

PMID- 1040034
TI  - Rickets and exposure to sunshine (presentation of two cases).

PMID- 1040035
TI  - An evaluation of nutrition classes for mothers in a pediatric clinic setting.

PMID- 1040037
TI  - [Editorial: Gentle delivery].

PMID- 1040036
TI  - Recent trends in infant carrying.  (The demise of the perambulator--a silent
      revolution in infant carrying methods and their effect on somatic and cognitive
      development in infants.

PMID- 1040038
TI  - [Diabetes in pregnancy].

PMID- 1040039
TI  - [Birth of a family].

PMID- 1040040
TI  - [Editorial: The harassed midwife in our maternity clinics].

PMID- 1040041
TI  - [Mother-child relationship; significant clinical observations].

PMID- 1040042
TI  - [Current aspects of thrombosis and oral contraceptives].

PMID- 1040043
TI  - [Editorial: Continuing education for midwives. Public health administration
      curriculum committee takes an affirmative stand in the matter].

PMID- 1040044
TI  - [The placenta must not be disposed of too quickly].

PMID- 1040045
TI  - [Use of safety belt during pregnancy].

PMID- 1040046
TI  - [Observations from daily activities in the nurse's life].

PMID- 1040047
TI  - [Public image of public health nurses].

PMID- 1040048
TI  - [A survey: exploring the sense of political awareness].

PMID- 1040049
TI  - [Possibility of intervention in the political process - where the nursing
      association is concerned].

PMID- 1040051
TI  - [Death in nursing. 11. Calm acceptance].

PMID- 1040050
TI  - [Applicability of Usui's theory on nursing].

PMID- 1040052
TI  - [Adverse reactions from drugs. 9. Adverse effects of digitalis].

PMID- 1040053
TI  - [General report on the meeting of the Japanese Nursing Association for the study
      of problems in nursing education].

PMID- 1040055
TI  - [Nurses around the world: the United States of America, Sri Lanka].

PMID- 1040054
TI  - [Adverse reactions to drugs. 10. Adverse effects of diuretics].

PMID- 1040056
TI  - [Undue expectations of practical nursing].

PMID- 1040057
TI  - [Current status of practical nurses - testimony obtained from the current
      situation].

PMID- 1040059
TI  - [A basic plan on the system of nursing].

PMID- 1040058
TI  - [Round-table discussion on the system of practical nursing for the public's
      health care].

PMID- 1040060
TI  - [Orientation for beginning nurses].

PMID- 1040061
TI  - [Elimination of the training is the first step in revising the system (for
      practical nursing)].

PMID- 1040062
TI  - [Nurses replies to expectations of the nursing profession].

PMID- 1040063
TI  - [Death in nursing. 12. Spring, be bright].

PMID- 1040064
TI  - [Adverse reactions of drugs. 11. Antihypertensive agents].

PMID- 1040065
TI  - [How "Futaba-en", a day nursery at the work place, came into being].

PMID- 1040066
TI  - [Expertise tested in the concerted action by the Minamata residents].

PMID- 1040067
TI  - [Visiting Morioka to meet the citizen's campaign for understanding].

PMID- 1040068
TI  - [From the locale of Minamata - activities of the traveling clinic].

PMID- 1040069
TI  - [Activities of the patients' organization - looking for solidarity].

PMID- 1040070
TI  - [Obstructions to public relations].

PMID- 1040071
TI  - [Raison d'etre of the concerted action by Minamata residents; especially the
      relationship between the right to live and the right to medical care].

PMID- 1040072
TI  - [The nursing profession's concern for the Minamata citizen's organization - as
      seen from a questionnaire].

PMID- 1040073
TI  - [Participation in the inservice training program for nursing management].

PMID- 1040074
TI  - [Nursing in the ICU and CCU. 1. General idea of ICU and CCU].

PMID- 1040075
TI  - [Tomorrow's image in white. 1. Be happy first].

PMID- 1040076
TI  - [Nurses around the world: Hong Kong, Poland].

PMID- 1040077
TI  - [Scenes of youth - I have unintentionally become a nurse. 1].

PMID- 1040078
TI  - Pediatric nurse practitioner preparation in a graduate program.

PMID- 1040079
TI  - [Prevention and treatment of hypertensive vascular disease].

PMID- 1040080
TI  - [Ischemic heart disease and exercise therapy following surgical treatment].

PMID- 1040081
TI  - [Chronic gastritis].

PMID- 1040082
TI  - [Round-shaped formations within the chest organs].

PMID- 1040083
TI  - [Urolithiasis and urolithic diathesis].

PMID- 1040084
TI  - [Tuberculosis of the kidneys].

PMID- 1040085
TI  - [Drug disease].

PMID- 1040086
TI  - [Specific features of water-electrolyte metabolism in old and senile patients].

PMID- 1040087
TI  - [Vitamins and aging processes].

PMID- 1040088
TI  - [The use of lasers in biology and medicine].

PMID- 1040089
TI  - [Nurse's role in a rehabilitation department].

PMID- 1040090
TI  - [Experience in the training of nurses for work in the intensive care ward].

PMID- 1040091
TI  - [An arrangement for calling patients].

PMID- 1040092
TI  - [An electric board for calling patients to the physiotherapy room].

PMID- 1040093
TI  - [Fungal diseases of the lungs].

PMID- 1040094
TI  - [Physical factors in the complex treatment of patients with pneumoconiosis].

PMID- 1040095
TI  - [Otitis media in infants].

PMID- 1040096
TI  - [Puncture catheterization of the subclavian vein in children].

PMID- 1040097
TI  - [Dermatomyositis].

PMID- 1040098
TI  - [Food allergy in infants].

PMID- 1040099
TI  - [Prevention and treatment of flatfoot].

PMID- 1040100
TI  - [New methods in physiotherapy for children].

PMID- 1040101
TI  - [Exercise therapy in children with rachitis].

PMID- 1040102
TI  - [Physical culture in digestive system diseases in children].

PMID- 1040103
TI  - [A room for health children in the polyclinic].

PMID- 1040104
TI  - [Nurse's functions in the pediatric resuscitation department].

PMID- 1040105
TI  - [Influence of the aminazine (chlorpromazine) group on cardiovascular activity in
      children].

PMID- 1040107
TI  - [Scientific work organization in polyclinic].

PMID- 1040106
TI  - [Experience in the prevention of dental caries in children of preschool age].

PMID- 1040108
TI  - [Role of a pediatric polyclinic in scientific work organization in preschool
      institutions].

PMID- 1040109
TI  - [Elements of scientific work organization in the catering unit of a hospital].

PMID- 1040110
TI  - [Chronic tonsillitis].

PMID- 1040111
TI  - Editorial: Reorganisation--is it working?

PMID- 1040112
TI  - Health education and the elderly.

PMID- 1040113
TI  - Developments in the treatment of sexual dysfunction.

PMID- 1040114
TI  - Drugs used in alcoholism.

PMID- 1040115
TI  - Editorial: Midwives and family planning.

PMID- 1040116
TI  - Assessment of placental function.

PMID- 1040117
TI  - Attitudes of a group of mothers to breast feeding. Part 2.

PMID- 1040118
TI  - Editorial: Remember Maria.

PMID- 1040119
TI  - Lipreading, hearing aids and the elderly.

PMID- 1040120
TI  - Drugs used for psoriasis.

PMID- 1040121
TI  - Editorial: Time for restraint.

PMID- 1040122
TI  - Pill or IUD?

PMID- 1040123
TI  - A survey of children's thoughts in hospital compared with what mothers feel.

PMID- 1040124
TI  - The school in the community.

PMID- 1040125
TI  - Pain and parenting.

PMID- 1040126
TI  - Drugs for scalp disorders.

PMID- 1040127
TI  - Mabel Liddiard memorial lecture; mothering: the facilitating environment.

PMID- 1040128
TI  - 11. Inservice education for senior midwives.

PMID- 1040130
TI  - Hospital smoke.

PMID- 1040129
TI  - Aminophylline used for premature labour.

PMID- 1040131
TI  - Guidelines for teacers of parentcraft and relaxation. 7. Relaxation.

PMID- 1040132
TI  - Decisions to treat critically ill patients: a comparison of social versus medical
      considerations.
AB  - A questionnaire survey shows that physicians in four medical specialties evaluate
      chronically and terminally ill patients not only in terms of the physiological
      aspects of illness but also in terms of the extent to which they are capable of
      interacting with others. A patient's potential capacity to perform his social
      roles depends upon his "salvageability," i;e., the likelihood that he will be
      able to resume his roles and the degree of irreversible physical or mental damage
      which indicates his capacity for resuming them. The priorities in terms of
      treatment are the following: (1) salvageable patients with physical damage; (2)
      salvageable patients with mental damage and unsalvageable patients with physical
      damage; (3) unsalvageable patients with mental damage. Within these catagories
      variables such as patient attitude, family attitude, age, and social class, which
      define the social environment of the patient, also influence the physician's
      decision to treat him. Studies of hospital records of cases in two of the
      specialties were consistent with they survey findings. The findings suggest that
      there is a disparity between the traditional ethic concerning the treatment of
      such patients and the actual behavior of many physicians. As a solution to the
      inconsistencies between ideal and actual behavior, the development of medical
      guidelines for the withdrawal of treatment with respect ot certain specifically
      defined conditions is recommended.

PMID- 1040133
TI  - The development of ambiguous federal policy: early and periodic screening,
      diagnosis, and treatment (EPSDT).
AB  - This paper examines why Congress's first major program for comprehensive health
      care to needy children took five years to begin even partial operation. An
      examination of the 1967 program's legislative history reveals that Congress paid
      little attention to EPSDT's implications: it was left ambiguous whether health
      (Title V) or welfare (Title XIX) would administer; costs were never clearly
      stated; eligibility and scope of services to be provided were left vague. Despite
      pressure from welfare rights interest groups, these ambiguities delayed the
      preparation of regulation and guidelines which never did succeed in resolving the
      question of overlapping jurisdiction and costs. In addition, many states'
      resistance to paying for the program further held up implementation. The paper
      concluded that: (1) Congress's and HEW's unwillingness to face up to the real
      costs of health programs threatens long-term public and state support for such
      programs; (2) division of responsibility between health and welfare lessens the
      impact of a program; (3) grant-in-aid programs give states the power to distort
      the intent of federal health policies; and (4) where states fail to implement
      such policies, initiatives may pass to consumer advocacy groups.

PMID- 1040134
TI  - New organizations out of old ones: teaching group practices out of private
      practice and outpatient departments.
AB  - A private group practice and a traditional hospital medical clinic are joined
      together as a teaching group practice for primary care (Internal Medical
      Associates). Responsible for revenues as well as costs, the practice is
      administered by a board of managers composed of physicians, nurses, and
      administrators in the practice. This decentralization of practice from the
      clinical department and hospital administration has resulted in (1) a reduction
      in the numbers of physicians needed for the practice, (2) a greater visit census
      with increased physician productivity, and (3) a reduced operating deficit and
      better understanding of transient and educational costs. The matrix organization
      of the board of managers has resulted in better communication and a commitment of
      the staff to common goals. Public demand for a single standard of care for
      patients of all backgrounds, professional aspirations to work in groups, and
      educators' interest in training outside the hospital converge to make such
      reorganizations of practical necessity.

PMID- 1040135
TI  - Teamwork in health care in the U.S.: a sociological perspective.
AB  - Reactions to teamwork, whether in health care, science and research, or in other
      areas, are seldom neutral. While some see in it a panacea that will help solve
      many stubborn organizational problems, others condemn it on a variety of grounds.
      Impetus to the development of team approaches to the delivery of health care and
      concern over their performance have been tied to a number of trends: a marked
      increase in specialization and division of labor as a result of expansion in
      health-related knowledge and technology, a corresponding emphasis upon
      coordination, a broadening concept of health and an increase in the types of
      activities included under its rubric, and a manpower shortage especially in the
      highly trained professions. This paper reviews current studies, important
      findings, and points out neglected dimensions. Themes prominent in the literature
      include: (a) status, power, authority, and influence; (b) roles and professional
      domains; and (c) decision making and communication. A number of important
      dimensions seem to be neglected, such as the effectiveness of teams as an
      approach to the delivery of services, the modes of organization and the dilemma
      of gate-keeping decisions, and the relations of team approaches to the manpower
      problems.

PMID- 1040136
TI  - [Regulation for nurses and hospitals].

PMID- 1040138
TI  - Services of the NRPB (National Radiological Protection Board).

PMID- 1040137
TI  - The rationale of safety assessment.

PMID- 1040139
TI  - Exhaust ventilation.

PMID- 1040140
TI  - [Visit to the newborn department].

PMID- 1040141
TI  - [Training for a human future through learning from animals].

PMID- 1040142
TI  - [Guidelines in procedures with ionizing irradiation].

PMID- 1040143
TI  - [Old age--a problem for society as a whole].

PMID- 1040144
TI  - [Functional field of registered nursing personnel in today's health care system].

PMID- 1040145
TI  - [Report on a study trip. Part 1].

PMID- 1040146
TI  - [Ethical principles for nursing].

PMID- 1040147
TI  - [Scheme for an inservice education arrangement].

PMID- 1040148
TI  - [Gastrointestinal hormones].

PMID- 1040149
TI  - [Care plan for patients with hepatitis].

PMID- 1040150
TI  - [Report on a study trip. Part 2].

PMID- 1040151
TI  - Raising the consciousness of nursing students.

PMID- 1040152
TI  - Teaching physical assessment.

PMID- 1040153
TI  - Process of product evaluation?

PMID- 1040154
TI  - Serendipity and objectivity.

PMID- 1040155
TI  - Creativity and nursing research.

PMID- 1040156
TI  - The senior year preceptorship.

PMID- 1040157
TI  - The school nurse practitioner.
AB  - Whatever the specific details of their practices, SNPs have shown themselves able
      to function effectively in their expanded roles because they have assumed more
      responsibility, initiative, interdependence, and independence in caring for
      children.  Specifically, they have learned to be confident of their decision
      making abilities, to adapt themselves to an expanded framework of nursing, and to
      regard themselves as highly qualified professionals.  What this means to the
      individual nurse practitioner, the parent and--most important--the child is well
      summed up in these remarks from Larea Younkman, SNP in the Denver Public Schools:
      "Previously," she writes, "my recommendations to the parents as to what to do and
      when, such as seeking medical attention, were frequently too general and
      consequently not heeded by the parent.  Now when I talk to a parent, I am not
      only confident of my findings but I'm also much more convinced that what I
      suggest is necessary.  As a result, parents are looking at SNPs differently,
      trusting our judgment, and, I think, following through on the advice we offer to
      a greater extent than previously."  Thus the SNP could well be the vital bridge
      between this country's traditional system of health care delivery and those
      children who are deprived of the care they need through reluctance, ignorance,
      parental apathy, or lack of available health care facilities.

PMID- 1040158
TI  - Editorial: They still make house calls.

PMID- 1040159
TI  - Community health nursing: a typology of practice.

PMID- 1040160
TI  - Community assessment: an epidemiological approach.

PMID- 1040162
TI  - An internship in community health nursing.

PMID- 1040161
TI  - Expanding the public health nurse's role in child care.

PMID- 1040163
TI  - Automobile transportation in community health services.

PMID- 1040164
TI  - A conceptual model for preventive health behavior.

PMID- 1040165
TI  - Audio: the oldest medium.

PMID- 1040166
TI  - Editorial: The two worlds of nursing.

PMID- 1040167
TI  - Changing the rules of the doctor-nurse game.

PMID- 1040169
TI  - NLN Convention '75.

PMID- 1040168
TI  - A conceptual framework for curriculum development.
AB  - A conceptual framework provides boundaries within which facts, concepts,
      theories, and propositions from three theoretical sources interact with clarity,
      coherence, and consistency. From the framework objectives are derived. The
      framework gives direction to the curriculum design. Finally, the conceptual
      framework serves as a background against which objectives can be tested. A
      conceptual framework for curriculum encourages systematic curriculum evaluation
      that will eventually allow us to more accurately describe, explain, predict, and
      control the work of curriculum.

PMID- 1040170
TI  - Clinical practicum in ambulatory care.

PMID- 1040171
TI  - Student evaluation by computer.

PMID- 1040172
TI  - Physicians' attitudes toward nurse-midwives.

PMID- 1040173
TI  - Symposium on restructuring maternity care. Forword.

PMID- 1040174
TI  - The pregnancy-resolution decisions of unwed adolescents.

PMID- 1040175
TI  - The effect of cost on patterns of maternity care.

PMID- 1040176
TI  - Maternity care: an attempt at an alternative.

PMID- 1040177
TI  - A consumer-oriented nurse-midwifery service.

PMID- 1040178
TI  - Regionalizing perinatal care in Wisconsin.

PMID- 1040179
TI  - Transforming a community hospital nursing service into a regional center.

PMID- 1040180
TI  - Education of the perinatal nurse clinician. Program and philosophy.

PMID- 1040181
TI  - Counseling patients with genetic abnormalities.

PMID- 1040182
TI  - Identifying and serving a multiply handicapped population. Deaf-blind children
      and their families.

PMID- 1040183
TI  - The socio-sexual development of the handicapped child. A preventive care
      approach.

PMID- 1040184
TI  - "On to the pub, or is it worth it".

PMID- 1040185
TI  - Dietitian role in the nursing home management plus health.

PMID- 1040186
TI  - The professional nurse and care of the aged.

PMID- 1040187
TI  - NHS failings highlighted by complaints. The ombudsman's first annual report.

PMID- 1040188
TI  - So he comes from a broken home.

PMID- 1040189
TI  - Sickle cell anaemia.

PMID- 1040190
TI  - Malabsorption.

PMID- 1040191
TI  - Psychopathic disorder.

PMID- 1040193
TI  - Science matters.

PMID- 1040192
TI  - Lassa fever.

PMID- 1040194
TI  - The modern nurse--applied scientist or ministering angel?

PMID- 1040195
TI  - Standards of nursing care--why are they falling?

PMID- 1040197
TI  - International family planning.

PMID- 1040196
TI  - Midwifery in Holland.

PMID- 1040198
TI  - Images of the mentally handicapped.

PMID- 1040199
TI  - A stitch in time...

PMID- 1040200
TI  - Symposium on childbirth - the daily miracle.

PMID- 1040202
TI  - The domiciliary midwife.

PMID- 1040201
TI  - Fetal development and care for the patient at risk.

PMID- 1040203
TI  - Antenatal preparation.

PMID- 1040204
TI  - Obstetric physiotherapy.

PMID- 1040205
TI  - Supportive care from the social services.

PMID- 1040206
TI  - Analgesia and anaesthesia.

PMID- 1040207
TI  - Nursing care in hospital: labour and post partum.

PMID- 1040208
TI  - Childbirth - the daily miracle. The health visitor's role.

PMID- 1040209
TI  - Villas for the mentally handicapped.

PMID- 1040210
TI  - Occupational health in the NHS.

PMID- 1040211
TI  - Persecution of the agencies.

PMID- 1040212
TI  - Ejection injuries.

PMID- 1040213
TI  - Stress incontinence.

PMID- 1040214
TI  - Physiotherapy in the treatment of stress incontinence.

PMID- 1040215
TI  - Recurrent diarrhoea in children.

PMID- 1040217
TI  - Management training - where now? (1).

PMID- 1040216
TI  - Psychological problems following birth and miscarriage.

PMID- 1040218
TI  - The cottage hospital.

PMID- 1040219
TI  - Life in Shivangaon; health care in an Indian village.

PMID- 1040220
TI  - 'Learning to live'.

PMID- 1040222
TI  - Aspects of nurse education and service in America.

PMID- 1040221
TI  - Holiday of a lifetime.

PMID- 1040223
TI  - Advice to travellers going abroad.

PMID- 1040224
TI  - The district nurse and the law.

PMID- 1040225
TI  - Professional advisory machinery--nursing and midwifery.

PMID- 1040226
TI  - Travel and the diabetic.

PMID- 1040227
TI  - [School health, a stepchild].

PMID- 1040228
TI  - [Laryngectomy: adaptation to mutilation, daily care].

PMID- 1040229
TI  - [Acute pancreatitis].

PMID- 1040230
TI  - [Current aspects of tuberculous meningitis].

PMID- 1040231
TI  - [Headache. II. Vascular, psychogenic and post-traumatic headaches].

PMID- 1040233
TI  - [Industrial medicine and migrant workers].

PMID- 1040232
TI  - [Epistaxis].

PMID- 1040234
TI  - [The young child and his mother: their problems in an urban environment].

PMID- 1040235
TI  - [Towards improved reception of emergencies in the hospital].

PMID- 1040236
TI  - [Protection of persons close to a patient treated with radium].

PMID- 1040237
TI  - [Enzyme inhibitors].

PMID- 1040238
TI  - [The industrial inspector, what's his job?].

PMID- 1040239
TI  - [Alcoholism at the steering wheel].

PMID- 1040240
TI  - [Asthma].

PMID- 1040241
TI  - [Embolization under vascular radiologic control].

PMID- 1040242
TI  - [Abdominal contusions; diagnosis and management].

PMID- 1040244
TI  - [French hospital system].

PMID- 1040243
TI  - [Sinusitis in children and infants].

PMID- 1040245
TI  - [Tabacco, tomorrow a familial habit].

PMID- 1040246
TI  - [The evolution of women's status in French society].

PMID- 1040247
TI  - [The Sudreau Report].

PMID- 1040248
TI  - [The French Red Cross toward the year 2000].

PMID- 1040249
TI  - [Puncture lavage of the abdomen].

PMID- 1040250
TI  - Adapting OR techniques to microneurosurgery.

PMID- 1040251
TI  - P.I.D. treatment: a growing problem for urban EDs.

PMID- 1040252
TI  - Revisions in practice acts expand role of nurses.

PMID- 1040253
TI  - Physical fitness; a key to emotional health.

PMID- 1040254
TI  - The transformation of the ED nurse. Part 2. Upgrading skills and status.

PMID- 1040255
TI  - An RR experience: as nurse and patient saw it.

PMID- 1040256
TI  - Drugs for acute respiratory failure.

PMID- 1040257
TI  - Emergency nursing--via helicopter!

PMID- 1040258
TI  - Putting a ceiling on homeowner's insurance.

PMID- 1040259
TI  - [Creativity at the sickbed. Characteristic of creative nursing groups - how one
      learns to push ideas through by necessity].

PMID- 1040260
TI  - [Intensive care].

PMID- 1040261
TI  - [Oral antidiabetics].

PMID- 1040262
TI  - [Radiation protection. II].

PMID- 1040263
TI  - [Pentecost in the hospital].

PMID- 1040265
TI  - [Study of health and nursing care activities].

PMID- 1040266
TI  - [Efficient work output?].

PMID- 1040264
TI  - [No vaccine nor washing machines].

PMID- 1040267
TI  - [Plasmapheresis nurse].

PMID- 1040268
TI  - [A stronghold for blood research].

PMID- 1040269
TI  - [Health services in the Soviet Union].

PMID- 1040270
TI  - [Single-use dosage insulin syringe standards].

PMID- 1040271
TI  - [Nurse's role in health care services].

PMID- 1040272
TI  - [GDR's endorsement of social politics importance].

PMID- 1040274
TI  - [Individualized patient care].

PMID- 1040273
TI  - [Public health nurse's role in health education].

PMID- 1040275
TI  - [Representatives, the trade union federation's link to the members].

PMID- 1040276
TI  - [Nursing process as the object for health care and nursing science].

PMID- 1040277
TI  - [Theoretical education makes it more interesting].

PMID- 1040279
TI  - [Economic depression delays actual income growth].

PMID- 1040278
TI  - [Labor market vocabulary].

PMID- 1040280
TI  - [Community health center improves health care access in East-Uudenmaa].

PMID- 1040281
TI  - [Membership activities shape a firm federation].

PMID- 1040282
TI  - [Scandinavian Council's ministerial committee recommends organization of higher
      education in Scandinavian schools for health occupations].

PMID- 1040283
TI  - [Importance of comprehensive vaccinations in Finland].

PMID- 1040284
TI  - [Equal responsibiltiy, important aspect. Equal rights dependenton breadwinner].

PMID- 1040285
TI  - [What do other health workers think about nurses?].

PMID- 1040286
TI  - [Nurses should be prepared for possibilities in higher education in their own
      field].

PMID- 1040287
TI  - [Effective hospital nursing activities?].

PMID- 1040288
TI  - [Oulu Central University Hospital's findings; child care cause of much
      absenteeism].

PMID- 1040289
TI  - [Working place food service should be part of working conditions].

PMID- 1040290
TI  - [The therapeutic dietician in the health center].

PMID- 1040291
TI  - [Occupational hygiene are working conditions].

PMID- 1040292
TI  - [Care process under scrutiny].

PMID- 1040294
TI  - [University nursing degree in Iceland].

PMID- 1040293
TI  - [Focus on the aged].

PMID- 1040295
TI  - [Infection control nurse position discussed in hospital hygiene symposium].

PMID- 1040296
TI  - The art and science of supervision. Your most precious possession: time.

PMID- 1040297
TI  - Developing a projected nurse staffing program.

PMID- 1040298
TI  - Staffing: the most basic nursing service problem.

PMID- 1040299
TI  - Public relations in nursing service.

PMID- 1040300
TI  - Student and pupil nurse wastage.

PMID- 1040301
TI  - Law for the nurse supervisor. Psychiatric patients in acute care hospitals.

PMID- 1040302
TI  - Editorial: Pause and reflect!

PMID- 1040303
TI  - Law for the supervisor nurse. Choose life or let die?

PMID- 1040304
TI  - On being a supervisor.

PMID- 1040305
TI  - Nursing guidelines for in-syringe mixtures.

PMID- 1040307
TI  - The art and science of supervision. Your leadership role.

PMID- 1040306
TI  - Creating harmony between supervisor and nurse.

PMID- 1040308
TI  - Editorial: The question of loyalty.

PMID- 1040309
TI  - [Editorial: Your and my responsibility for the Norwegian Nurses' Association].

PMID- 1040310
TI  - [Cooperative organization in health and social sectors needs education not
      derogation].

PMID- 1040311
TI  - [Preventive health services; ideals and realities].

PMID- 1040312
TI  - [Special education for nurses in Tromso Central Hospital].

PMID- 1040313
TI  - [Infusion-fluid container of pliable plastic. Risk with admixture of drug
      concentrations].

PMID- 1040314
TI  - [Special education in psychiatric nursing].

PMID- 1040316
TI  - [Nurses' rights].

PMID- 1040315
TI  - [Large department - a negative solution to resource and priority problems].

PMID- 1040317
TI  - [Euthanasia: a discussion panel for the elaboration of the nurse's role in the
      face of this ethical problem].

PMID- 1040318
TI  - [New system of continued education in a small hospital].

PMID- 1040319
TI  - [Sociomedical assistance inside and outside of the institution].

PMID- 1040320
TI  - [Child abuse - the battered child syndrome].

PMID- 1040321
TI  - [Nursing activities - a systematic study of nursing processes].

PMID- 1040322
TI  - [Parliamentary report No. 17 (1974-75) on expanded structure and organization of
      higher education].

PMID- 1040323
TI  - [Parliamentary report No. 9 (1974-75). Hospital construction in relation to the
      regional health care system].

PMID- 1040324
TI  - [China: health services in another fashion].

PMID- 1040325
TI  - [Pension scheme for health visitors].

PMID- 1040326
TI  - [We need better preparation to work in developing countries].

PMID- 1040327
TI  - [Nurses need support in planning committees].

PMID- 1040328
TI  - [Independent nursing groups. 1: a new form of organization can increase work
      satisfaction on the wards].

PMID- 1040329
TI  - [It may mean a day nursery for the child: serious symptoms disappear without
      expensive treatment].

PMID- 1040330
TI  - [Nurse in a Greenland rural area: there are constantly children with calcium and
      vitamin D deficiency].

PMID- 1040332
TI  - [Reflections of a clinical specialist group leader].

PMID- 1040331
TI  - [Interprofessional Association for Medical Education].

PMID- 1040333
TI  - [Independent nursing group. 2: can provide a more informal milieu around the
      patient].

PMID- 1040334
TI  - [Nurse on a Faero Island: nurses have a greater responsibility in a small
      community].

PMID- 1040335
TI  - [Drug catalogs are also an aid to the nurse].

PMID- 1040336
TI  - [A department with cooperative leadership on a trial basis].

PMID- 1040338
TI  - [Nationwide fire inspection following the Hafnia catastrophe shows: a large
      number of nursing homes are purely firetraps].

PMID- 1040337
TI  - [Study trip during a final course provided new incentive].

PMID- 1040339
TI  - [National course for hospital and public health nurses: how does cooperation in
      the public health sector function?].

PMID- 1040340
TI  - [Organizational development in the hospital: an advantage which started with one
      or a few hospital units].

PMID- 1040341
TI  - [Report on the current situation of nursing and old age homes in Ringkobing Amt:
      only 26 out of 71 nursing homes meet medical certification for admission of new
      residents].

PMID- 1040342
TI  - [Increased occurrence of headlice among children in day care centers].

PMID- 1040343
TI  - [Insurance for illness or industrial accidents here and abroad].

PMID- 1040344
TI  - [Participation in an ambulance run: the most shocking thing was the environment
      where patients came from].

PMID- 1040345
TI  - [All nurses should read the proposal for a new education system].

PMID- 1040346
TI  - [Amnesty International is a nonpolitical organization: workers for the release of
      political prisoners].

PMID- 1040347
TI  - [A nurse works with drug addicts as a social service colleague: duties demand 16
      18 hours work weekly].

PMID- 1040348
TI  - [On coffee and nursing].

PMID- 1040349
TI  - [Great demand for pediatric nurses].

PMID- 1040350
TI  - [Dietary service in Kolding in an untraditional manner].

PMID- 1040351
TI  - [Is the nurse a proffessional? Nurses should learn to carry out a professional
      interview].

PMID- 1040352
TI  - [Danish nurse in a Jordan hospital: nurses rarely actively participate in work].

PMID- 1040353
TI  - [Sequelae of immobilization].

PMID- 1040354
TI  - [Team nursing in the coronary care units: nurses have closer contact with their
      patients].

PMID- 1040355
TI  - [Heart faint - cardiac syncope. 1: when interruption of heart rhythm results in a
      faint].

PMID- 1040356
TI  - [Nurses' drug information: verapamil NFN, INN (Isoptin)].

PMID- 1040357
TI  - [Delegate for the Red Cross in Niger: practically no 2-to-6-year-old children in
      the disaster area].

PMID- 1040358
TI  - [Student nurses' attitude towards the dying patient].

PMID- 1040360
TI  - [Various central functions of a new hospital].

PMID- 1040359
TI  - [Heart faint - cardiac syncope. 2: patient can be saved by a blow to the breast].

PMID- 1040361
TI  - [Comment on the guidelines for public health nursing regulations: standardization
      ensures public health nurses' necessary possibilities].

PMID- 1040362
TI  - [This is how a nurse's work day can pass in the north Swedish wilderness: a train
      ride of 180 Km and 6 hours of work].

PMID- 1040363
TI  - [Nursing in cardiological development: must frequently initiate treatment for
      acute heart arrest].

PMID- 1040364
TI  - [How shall we solve the problems of many abortions?].

PMID- 1040365
TI  - [Cardiac pacemaker treatment. 2. Observation of patients with pacemakers].

PMID- 1040366
TI  - [The new supervisor of the nursing department of the public health
      administration: nurses should continue to have a broad basic education].

PMID- 1040367
TI  - [Nurses must participate in care planning of acute admissions to the hospital].

PMID- 1040368
TI  - [They have neither a superintendant nor a matron: hospital with a consistently
      collective leadership].

PMID- 1040369
TI  - [Primary nursing - assigned patient care: makes it possible to give total nursing
      care].

PMID- 1040370
TI  - [Get the wrong aids and frequently too late].

PMID- 1040371
TI  - [Staff and patients get on well together in the hospital].

PMID- 1040372
TI  - [Has health personnel's interest for the individual patient diminished?].

PMID- 1040373
TI  - [School nurses have a hard time to manage their many work activities].

PMID- 1040374
TI  - [Concentrate on child care during the next 10 years].

PMID- 1040375
TI  - [Editorial: Children and employment].

PMID- 1040376
TI  - [There should be custodial allowance in child care shouldn't there?].

PMID- 1040377
TI  - [Fiber poor diet causes intestinal diseases].

PMID- 1040378
TI  - [Manpower in nursing service].

PMID- 1040379
TI  - [Apropos psychotherapy].

PMID- 1040380
TI  - [Statistics and fact].

PMID- 1040381
TI  - [Build half a million places for child care from now till 1985].

PMID- 1040382
TI  - [Custodial allowance gives freedom of choice to families with children].

PMID- 1040383
TI  - [Certification committee - a new proposal].

PMID- 1040384
TI  - [Editorial: A universal plan for equality].

PMID- 1040385
TI  - [What happens in the family when the housewife takes a job?].

PMID- 1040386
TI  - [The new IS-system sweeps aside old routines].

PMID- 1040387
TI  - [Swedish Nursing Association's publishing firm discontinued].

PMID- 1040388
TI  - [Equality between sexes extends to 6-hour work day].

PMID- 1040389
TI  - [Public (TV) channel debate on the nursing shortage].

PMID- 1040390
TI  - [Organization of the Swedish Association for Salaried Health and Nursing
      Employees - report of the work group].

PMID- 1040391
TI  - [New local and regional organization for the Swedish Central Organization of
      Salaried Employees].

PMID- 1040392
TI  - [Maximum 800 students per school nurse is considered by the school health care
      committee].

PMID- 1040393
TI  - [Anesthesia crisis in Stockholm - a problem of sparse population?].

PMID- 1040394
TI  - [Manpower in nursing service].

PMID- 1040395
TI  - [Heart and vascular diseases - a symposium: introduction].

PMID- 1040396
TI  - [What is heart monitoring or intensive coronary care?].

PMID- 1040397
TI  - [Legal position of the nurse in the coronary care unit].

PMID- 1040398
TI  - [Principles of a cholesterol-lowering diet].

PMID- 1040399
TI  - [Relations with and care of the seriously ill and dying within the CCU].

PMID- 1040400
TI  - [Care of the patient and his family].

PMID- 1040401
TI  - [Relations with the seriously ill and dying patient within the coronary care
      unit].

PMID- 1040402
TI  - [Public opinion (influencing) and dental care].

PMID- 1040404
TI  - [A change in attitude as therapy for improved nursing].

PMID- 1040403
TI  - [Regulation of hormonal equilibrium via feedback mechanism].

PMID- 1040405
TI  - [The need for MBOV (intermediate professional nursing education) - from the point
      of view of public health care; on the need for day schools].

PMID- 1040406
TI  - [Stimulation of sick babies at home and in the hospital].

PMID- 1040407
TI  - [Nose irrigation, gargling, steam baths].

PMID- 1040408
TI  - [Report on reality orientation in the psychiatry].

PMID- 1040409
TI  - [Quality of nursing care. The nurse herself is responsible for quality of nursing
      care].

PMID- 1040410
TI  - [The immobilization mattress].

PMID- 1040411
TI  - [The waterbed in service].

PMID- 1040413
TI  - [Research in psychiatric nursing].

PMID- 1040412
TI  - [Authorization for medical procedures for nurses; various legal aspects].

PMID- 1040414
TI  - [Letter to an epileptic patient].

PMID- 1040415
TI  - [Drugs in the elderly].

PMID- 1040416
TI  - [Various observation on the intermediate professional nursing education].

PMID- 1040417
TI  - [Coricosteroids].

PMID- 1040418
TI  - [The nurse in the extramural social psychiatric health care].

PMID- 1040419
TI  - [Child psychiatry].

PMID- 1040420
TI  - [Diuretics].

PMID- 1040421
TI  - [Scientifically base responsibility in nursing].

PMID- 1040422
TI  - [Nursing education from an agogic perspective].

PMID- 1040423
TI  - The feline corneal nigrum.

PMID- 1040424
TI  - Critical tests of the benzimidazole anthelmintic, fenbendazole, in the horse.

PMID- 1040425
TI  - Osteochondrosis dissecans of the equine shoulder joint.

PMID- 1040426
TI  - Torsion of the splenic pedicle in a St. Bernard.

PMID- 1040427
TI  - Amphotericin B therapy in two cases of feline cryptococcosis.

PMID- 1040428
TI  - A case of cranio-mandibular osteopathy in a Labrador Retriever.

PMID- 1040429
TI  - Clinical evaluation of tylosin in treatment of respiratory tract infections in
      cats.

PMID- 1040430
TI  - Ovariohysterectomy by the flank approach.

PMID- 1040431
TI  - Extirpation of a mammary growth (a photographic essay).

PMID- 1040432
TI  - Pyometra in a raccoon.

PMID- 1040433
TI  - Parathyroid adenoma in a tortoise.

PMID- 1040434
TI  - A clinical evaluation of Staphylococcus aureus bacterin in the control of
      staphylococcal mastitis in cows.

PMID- 1040435
TI  - Vitamin B1 deficiency in ruminants.

PMID- 1040436
TI  - Peroral use of a special dietary food as a source of electrolytes in diarrheic
      calves.

PMID- 1040437
TI  - Prevention of baby pig anemia with amino acid chelates.

PMID- 1040438
TI  - Dominican holiday (?).

PMID- 1040439
TI  - Are convertibles the answer to your investing problem?

PMID- 1040440
TI  - How to share income with a younger associate.

PMID- 1040441
TI  - Is there a VIP you've forgotten?

PMID- 1040442
TI  - [Uropepsinogen and gastric secretion in duodenal ulcer].

PMID- 1040443
TI  - Is it possible to look forward without looking back?

PMID- 1040444
TI  - Perspectives in nursing the mentally handicapped.

PMID- 1040446
TI  - An approach to general nursing care.

PMID- 1040445
TI  - Standards of nursing care.

PMID- 1040447
TI  - The role of the nurse in shock.

PMID- 1040448
TI  - [Duration of the professional life of a nurse: a matter of fact or a challenge
      for action?].

PMID- 1040450
TI  - [Goals in nursing care services].

PMID- 1040449
TI  - [The child and death].

PMID- 1040451
TI  - [Legal questions of the standard employment agreement illustrated by the example
      of standard employment agreement for nursing personnel].

PMID- 1040452
TI  - [Parttime employment in industry, trade and commerce].

PMID- 1040453
TI  - [Significance of group dynamics for employment conditions of nursing personnel].

PMID- 1040454
TI  - [The Senior Citizens' Circle of Migros-Ticino].

PMID- 1040455
TI  - [Congenital malformations of the urogenital system].

PMID- 1040456
TI  - [Historical note on skin diseases - current notes on veneral diseases].

PMID- 1040457
TI  - [Team nursing].

PMID- 1040458
TI  - [Preparation for leadership: a philosophy].

PMID- 1040459
TI  - [The position of the elderly person within the family].

PMID- 1040460
TI  - [Swiss agency for foreign nursing personnel].

PMID- 1040461
TI  - [Prevention of malnutrition in developing countries].

PMID- 1040462
TI  - [Do you sleep yourself to health? Regulation in the rest phase and physical
      mental activity].

PMID- 1040463
TI  - [The nurse in fiction: wanted; new nurse heroines].

PMID- 1040464
TI  - Differences in susceptibility of Enterobacteriaceae and penicillin-resistant
      Staphylococcus aureus to tetracycline and minocycline.
AB  - Two hundred strains of penicillin-resistant Staphylococcus aureus and 311
      isolates of Enterobacteriaceae were compared for their susceptibility to
      tetracycline and minocycline. Thirteen and one-half percent of the staphylococcal
      isolates were resistant to tetracycline but susceptible to minocycline.
      Similarly, 24% of the enterobacterial isolates were found to be tetracycline
      resistant but susceptible to minocycline. Of a total of 511 recent clinical
      isolates, 14.5% were susceptible to minocycline but were tetracycline resistant.

PMID- 1040465
TI  - Factors affecting drug action.

PMID- 1040466
TI  - Life times: doctor's dilemma.

PMID- 1040467
TI  - Colostomates: the mosaic of stress and implied care.

PMID- 1040468
TI  - Community psychiatry.

PMID- 1040469
TI  - The practical strand in--the making of a nurse educator.

PMID- 1040470
TI  - Will the charge nurse ever change her spots?

PMID- 1040471
TI  - Editorial: Making a threat.

PMID- 1040473
TI  - Crisis therapy.

PMID- 1040472
TI  - Working with the Ngangkari.

PMID- 1040474
TI  - Vitamin D.

PMID- 1040475
TI  - Life times: There are more things...

PMID- 1040477
TI  - Editorial: What's in an image?

PMID- 1040478
TI  - Feminism and nursing.

PMID- 1040476
TI  - A viable program for schizophrenic out-patients.

PMID- 1040479
TI  - Alcoholism--a family disease.

PMID- 1040480
TI  - The matron as a phenomenon.

PMID- 1040481
TI  - Evaluation of community health nursing.

PMID- 1040482
TI  - Domiciliary care of sick children in Birmingham - its history and development.

PMID- 1040483
TI  - The home care scheme in Paddington.

PMID- 1040484
TI  - A program of integrated hospital and home nursing care for children.

PMID- 1040485
TI  - Gateshead home nursing scheme: exercise in co-operation.

PMID- 1040486
TI  - Paediatric day-case surgery in Southampton.

PMID- 1040488
TI  - The placenta--mediator of nourishment and protective barrier.

PMID- 1040487
TI  - Hospitals and children.

PMID- 1040489
TI  - So, you want your child to play sport.

PMID- 1040490
TI  - Theory of breast milk substitution.

PMID- 1040492
TI  - Poisoning and its treatment.

PMID- 1040491
TI  - Aboriginal unit plays a vital role in children's health.

PMID- 1040493
TI  - Which milk should I use?

PMID- 1040494
TI  - The nurse as teacher.

PMID- 1040495
TI  - Treatment of accidents and poisons in children.

PMID- 1040496
TI  - The Adelaide Children's Hospital School.

PMID- 1040498
TI  - Kenya's family plans.

PMID- 1040497
TI  - Paediatrics--1975.

PMID- 1040499
TI  - Hypnotherapy in paediatrics.

PMID- 1040500
TI  - Do-it-yourself help for the handicapped.

PMID- 1040501
TI  - Parent participation.

PMID- 1040502
TI  - Child abuse.

PMID- 1040503
TI  - Role of the intensive care nurse.

PMID- 1040504
TI  - Cot death syndrome.

PMID- 1040505
TI  - Is swimming a high priority?

PMID- 1040506
TI  - Current progress in paediatric surgery.

PMID- 1040507
TI  - Paediatric nurse practitioners.

PMID- 1040508
TI  - The home care unit at St. Mary's Hospital, London, W2.

PMID- 1040509
TI  - Care through parent program.

PMID- 1040510
TI  - Children's hospital philosophy.

PMID- 1040511
TI  - The progeny of childhood cancer survivors.

PMID- 1040512
TI  - Health Commission of New South Wales.

PMID- 1040514
TI  - Epidural analgesia in obstetrics.

PMID- 1040513
TI  - Anaemia.

PMID- 1040515
TI  - Puerperal psychosis.

PMID- 1040516
TI  - CCNA (Critical Care Nurses' Association): teaching in the critical care unit.

PMID- 1040517
TI  - Building bridges of understanding.

PMID- 1040518
TI  - The effects of nursing home size on resident isolation, life satisfaction.

PMID- 1040519
TI  - Maternal and foetal assessment and nursing management during labor.

PMID- 1040520
TI  - Some aspects of anaemia in pregnancy.

PMID- 1040521
TI  - Background to drug users.

PMID- 1040522
TI  - The work of the Planning Appeal Board.

PMID- 1040523
TI  - Calvary Hospital graduation ceremony.

PMID- 1040525
TI  - How safe are our public swimming pools?

PMID- 1040524
TI  - Stress, occupation and health.

PMID- 1040526
TI  - Drug use by the young population of Melbourne.

PMID- 1040527
TI  - Sombre picture of NHS.

PMID- 1040528
TI  - Breakthrough in fight against malaria.

PMID- 1040529
TI  - First paediatric course in Queensland.

PMID- 1040531
TI  - The special features of road first aid.

PMID- 1040530
TI  - The matron.

PMID- 1040532
TI  - Occupational health nursing education in New South Wales.

PMID- 1040533
TI  - An emerging concept in human relations.

PMID- 1040535
TI  - From a dream to a reality.

PMID- 1040534
TI  - Epileptics... a community responsibility.

PMID- 1040536
TI  - Challenges in emergency nursing - all that jazz!!!

PMID- 1040537
TI  - Leprosy control in Rhodesia.

PMID- 1040539
TI  - The nurse and the blind patient.

PMID- 1040538
TI  - 1975--International Women's Year. Women and the law.

PMID- 1040540
TI  - The challenge of change.

PMID- 1040541
TI  - Sex discrimination and legislation.

PMID- 1040542
TI  - Epileptics, a community responsibility.

PMID- 1040543
TI  - Old age in Australia.

PMID- 1040544
TI  - No easy exit from slavery behind the veil.

PMID- 1040545
TI  - Another view of nursing education.

PMID- 1040546
TI  - The polytechnic scheme: it must be revised.

PMID- 1040547
TI  - Grief, a part of living.

PMID- 1040548
TI  - Indian health in white man's society.

PMID- 1040549
TI  - The nurse.

PMID- 1040550
TI  - An evaluation of the use of intraventricularly administered [3H]5
      hydroxytryptamine as a marker for endogenous brain 5-hydroxytryptamine.
AB  - Following the intraventricular injection of a small amount of [3H]5
      hydroxytryptamine ([3H]5-HT), the amount of radioactivity in telencephalic
      structures on the injected side was 6--7 times larger than that in corresponding
      areas on the opposite side. Moreover, a multiphasic disappearance of [3H]5-HT
      from whole brain or midbrain was found after the intraventricular injection of
      the labeled amine. However, after the intraventricular injection of
      [3H]tryptophan, the levels of [3H]5-HT in midbrain declined in a monophasic
      manner. A significant portion of the labeled amine derived from
      intraventricularly administered [3H]5-HT was resistant to the depleting effect of
      Ro4-1284 or to that elicited by destruction of the midbrain raphe nuclei, both of
      which caused an almost complete loss  of endogenous 5-HT and labeled 5-HT formed
      from tryptophan. It thus appears that the intraventricular injection of [3H]5-HT
      leads to the formation of artifactual pools which are not present if the amine is
      synthesized in vivo. Studies with 6-hydroxydopamine suggested, however, that
      uptake of [3H]5-HT into adrenergic neurons did not occur to any great extent.

PMID- 1040551
TI  - Proteus morganii meningitis treated with trimethoprim-sulfamethoxazole (co
      trimoxazole).

PMID- 1040552
TI  - [Routine nursing activities and nurse-patient relationship. A case study].

PMID- 1040553
TI  - [Humanity and illness - an impression by the translator of J. H. van den Berg's
      "The Psychology of the Sickbed"].

PMID- 1040554
TI  - [The International Nursing Index].

PMID- 1040555
TI  - [Clinical nursing of children with cerebral palsy - an experience of the last 3
      years].

PMID- 1040556
TI  - [Significance and methods of literature searching in nursing].

PMID- 1040557
TI  - [True nature of clinical nursing. (15)].

PMID- 1040558
TI  - [The ideal interaction between mother and child, and an observation on human
      development. A case study involving an autistic child and an apprehensive
      mother].

PMID- 1040559
TI  - [The group and its dynamics. 4].

PMID- 1040560
TI  - [Opinion of the study group of the German Nurses' Association on the reform of
      nurses' and pediatric nurses' education].

PMID- 1040561
TI  - [Design for a framework arrangement for nursing service].

PMID- 1040562
TI  - [Nursing care in neurosurgery].

PMID- 1040563
TI  - [Nursing care in neurosurgery from the physician's viewpoint].

PMID- 1040564
TI  - [Experiences and reflections on continued education].

PMID- 1040565
TI  - [Position of the working mother].

PMID- 1040566
TI  - [Examination report on nursing care of a child with herpes zoster and
      lymphogranulomatosis].

PMID- 1040567
TI  - [Present-day psychosomatic medicine - experiences and reflections].

PMID- 1040568
TI  - [Medical and psychological aspects of the disease hemophilia].

PMID- 1040569
TI  - [The professional status of speech therapists and their contribution to the
      "right to speech"].

PMID- 1040570
TI  - [The fate of patients with hearing, voice and speech disorders].

PMID- 1040571
TI  - [The role of nursing service in the hospital].

PMID- 1040572
TI  - [The hospital as a place of education for the nursing profession].

PMID- 1040573
TI  - [The child with cerebral palsy and his family. Report of a continued education
      course for pediatric nurses].

PMID- 1040574
TI  - [Examination observation on a premature infant with consumption coagulopathy and
      irriversible septic shock].

PMID- 1040575
TI  - [Microbiological and pharmacokinetic aspects of antibiotic therapy].

PMID- 1040576
TI  - [Specific prevention of tetanus in trauma].

PMID- 1040577
TI  - [Health characteristics of chemical poisons used in agriculture].

PMID- 1040578
TI  - [Errors and hazards in blood transfusion].

PMID- 1040579
TI  - [Botkin's disease (clinical aspects, diagnosis and prevention)].

PMID- 1040580
TI  - [Treatment of purulent wounds].

PMID- 1040581
TI  - [Experience in the use of analgetic mixtures for the arrest of acute pain
      syndrome].

PMID- 1040582
TI  - [Present-day requirements in health education].

PMID- 1040583
TI  - [Experience in health education of the population for the health protection of
      children at the feldsher-obstetrical center].

PMID- 1040584
TI  - [Dispensary treatment of workers at a machine-building plant].

PMID- 1040586
TI  - [Radiation sickness].

PMID- 1040585
TI  - [Experience in the training of health teams].

PMID- 1040587
TI  - [Echinococcosis of the liver].

PMID- 1040588
TI  - [Pathogenesis of hemorrhages in uterine myomas].

PMID- 1040589
TI  - [Dental caries and its prevention].

PMID- 1040590
TI  - [Current problems of donorship].

PMID- 1040591
TI  - [Organization and mass immunization of the population].

PMID- 1040592
TI  - [A method of prehospital examination of the patient in emergency surgical
      conditions].

PMID- 1040593
TI  - [Hygiene implications of beach rest (material for a talk)].

PMID- 1040594
TI  - [Initial health instruction for milkmaids].

PMID- 1040595
TI  - [New equipment for maternity homes].

PMID- 1040596
TI  - [Methods of protecting man from attacks by bloodsucking flies and ticks in
      districts allotted for new town construction].

PMID- 1040597
TI  - [Hypertrophic pyloric stenosis in infants].

PMID- 1040598
TI  - [Exercise tests in cardiology].

PMID- 1040599
TI  - [Obesity].

PMID- 1040600
TI  - [Smallpox].

PMID- 1040601
TI  - [Insect bite allergies].

PMID- 1040602
TI  - [Rickettsia].

PMID- 1040603
TI  - [Diagnosis of splenomegaly].

PMID- 1040604
TI  - [Hepatic colic].

PMID- 1040605
TI  - [Health care legislation: the hospital].

PMID- 1040606
TI  - [Decubitus ulcer].

PMID- 1040607
TI  - [Should continued education be obligatory?].

PMID- 1040608
TI  - [A curriculum for the benefit of a greater majority].

PMID- 1040609
TI  - [Community health put into practice].

PMID- 1040610
TI  - [The evolution of statistical quality control].

PMID- 1040611
TI  - [The child as a good-luck object or the child as a burden].

PMID- 1040612
TI  - [Comparative study of warm moist compresses].

PMID- 1040613
TI  - Attitudes towards student nurse allocation programmes.

PMID- 1040614
TI  - Health problems and nursing practice in sub-Saharan Africa.

PMID- 1040615
TI  - A study of oral hygiene in the geriatric patient.

PMID- 1040617
TI  - Paradoxes and the undergraduate student nurse.

PMID- 1040616
TI  - Professional absorption in Israel of nurse-immigrants from the USSR.

PMID- 1040618
TI  - A new look at nursing education.

PMID- 1040619
TI  - Cross-cultural psychotherapy.

PMID- 1040620
TI  - Automation of the health care system: implications for nursing. Part 2. Change
      strategies for nurses.

PMID- 1040621
TI  - Problems and progress in Honduras.

PMID- 1040622
TI  - The nurse within the health team.

PMID- 1040623
TI  - Administration in nursing service--the stimulus for change.

PMID- 1040624
TI  - Change in nursing in Nigeria.

PMID- 1040625
TI  - Thoughts on a new approach to public health nursing.

PMID- 1040626
TI  - Migration of Iranian nurses to the U.S.: a study of one school of nursing in
      Iran.

PMID- 1040627
TI  - Minocycline sensitivity related to the phage type of multiply resistant
      staphylococci.
AB  - Clinical isolated of multiply antibiotic-resistant strains of Staphlococcus
      aureus were divided into three  groups by phage typing. The most prevalent type,
      which is usually cloxacillin resistant, was found to be moderately sensitive to
      minocycline. Unfortunately the degree of sensitivity is not sufficient to warrant
      the use of the antibiotic in severe staphlococcal infection.

PMID- 1040629
TI  - Extra benefits from the new pension legislation.

PMID- 1040628
TI  - Pediatric preceptor programs.

PMID- 1040630
TI  - Medicolegal pitfalls in emergency room care.

PMID- 1040632
TI  - Nicobid has advantages you don't get with nicotinic acid tablets.

PMID- 1040631
TI  - Diagnosis and treatment of uncomplicated hay fever.

PMID- 1040633
TI  - More on OMT in obstetric care.

PMID- 1040634
TI  - Changing trends in the diagnosis and management of cervical neoplasia.

PMID- 1040635
TI  - Wegener's granulomatosis: report of a case.

PMID- 1040636
TI  - The effects of fetal monitoring on oxytocin inductions.

PMID- 1040637
TI  - Studies of reflex communications between dermatomes and jejunum.

PMID- 1040638
TI  - Spinal fixation: background and progress.

PMID- 1040639
TI  - Effect of denervation on the protein electrophoretic patterns of slow and fast
      skeletal muscles.

PMID- 1040640
TI  - Renal dipeptidase of swine and man.

PMID- 1040641
TI  - Helping to make his last dream a reality.

PMID- 1040642
TI  - A gerontological nurse looks at home care.

PMID- 1040643
TI  - Life is beautiful at 87.

PMID- 1040644
TI  - Old, aged, or elderly... What's in a name?

PMID- 1040645
TI  - Remotivation therapy: a way to reach the confused elderly patient.

PMID- 1040646
TI  - American Medical Association invites nursing leaders to help in implementing
      medical director concept in nursing homes.

PMID- 1040647
TI  - Gerontology centers interdisciplinary approach to aging education.

PMID- 1040648
TI  - [Some fundamentals of emotional growth in children].

PMID- 1040649
TI  - [Play as a means of communication with children].

PMID- 1040650
TI  - [Communication and adaptation between mother and newborn infant].

PMID- 1040651
TI  - [We improved our help to mothers taking care of their premature babies].

PMID- 1040652
TI  - [Significance of the duration of early contact between mothers and their newborn
      infants].

PMID- 1040653
TI  - [Helping the sick child to cope with the stress of hospitalization].

PMID- 1040654
TI  - [Reactions of children to visual deprivation].

PMID- 1040655
TI  - [The use of regression by a 4-year-old boy during hospitalization].

PMID- 1040656
TI  - [Community health nursing and child health in Taiwan].

PMID- 1040657
TI  - [The evaluation of the infant nutrition program in Tapei Public Health Teaching
      and Demonstration Center].

PMID- 1040658
TI  - [A projection of demand and supply of nurses and midwives in Taiwan].

PMID- 1040659
TI  - [On care of young children].

PMID- 1040661
TI  - New concepts in dietary management of diabetes.

PMID- 1040660
TI  - [Recognizing children's speech development and problems].

PMID- 1040662
TI  - Using TA to become OK.

PMID- 1040663
TI  - Beneath the tubes; behind the monitor.

PMID- 1040665
TI  - LPNs lead in inservice.

PMID- 1040664
TI  - D.C. Village is alive again.

PMID- 1040666
TI  - Continuing education: who is going to pay for it?

PMID- 1040667
TI  - They wait without.

PMID- 1040669
TI  - Editorial: Why delay detection?

PMID- 1040668
TI  - The new day of the professional. A reminder to licensed practical/vocational
      nurses.

PMID- 1040670
TI  - Preventing complications of alcoholism.

PMID- 1040671
TI  - The nursing process: the history... the beginning. 1.

PMID- 1040672
TI  - Transactional analysis: improving the nurse/patient relationship.

PMID- 1040673
TI  - Emergency care. On the scene.

PMID- 1040674
TI  - Helping the hospitalized addict.

PMID- 1040675
TI  - SVNs in mock disaster.

PMID- 1040676
TI  - Further evolution of a strain of Staphylococcus aureus in vivo: evidence for
      significant inactivation of flucloxacillin by penicillinase.
AB  - A strain of Staphylococcus aureus (no. FAR4) has been isolated at intervals, for
      32 months, from the sputum of a patient with cystic fibrosis of the lung. Changes
      in the properties of isolates of this strain over the first 18 months have been
      reported previously (Lacey et al., 1973 and 1974). During the last 14 months (May
      1973 to July 1974), further evolution has occurred to produce a total of 31
      distinct phenotypes. Recent changes are as follows. 1. The ability of isolates to
      produce penicillinase in vitro was closely correlated with flucloxacillin
      therapy. Inactivation of flucloxacillin by penicillinase was demonstrated by
      diffusion testing (but not MIC determination) in vitro and may have occurred to a
      significant extent in vivo. 2. Lincomycin-resistant mutants slowly disappeared
      from the sputum after the termination of clindamycin therapy. 3. All of the
      recent isolates were resistant to erythromycin, possibly because of the linkage
      of the genes coding for erythromycin resistance with those coding for the
      production of delta-haemolysin; delta-haemolysin may be an important "virulence
      factor".

PMID- 1040677
TI  - Administrative qualification or seniority.

PMID- 1040678
TI  - International Women's Year.

PMID- 1040679
TI  - A new era for women.

PMID- 1040680
TI  - Women's International Year and the nurse.

PMID- 1040681
TI  - "The role of women: some common myths".

PMID- 1040682
TI  - Nursing care standards in the hospital area.

PMID- 1040683
TI  - Second instalment of a talk (leprosy).

PMID- 1040685
TI  - Ward sisters discuss the process of administration and its application to promote
      quality patient care.

PMID- 1040684
TI  - Editorial: International Women's Year.

PMID- 1040686
TI  - [Status of maternal and child health care in Okinawa].

PMID- 1040687
TI  - [Use of a monitoring system during delivery].

PMID- 1040688
TI  - [Home for unwed mothers and planning of thier lives. A visit to "Jiai Ryo" at
      Shinjuku-ku, Tokyo].

PMID- 1040689
TI  - [Puerperal nursing in the week following delivery].

PMID- 1040690
TI  - [Evaluation of factors related to perinatal mortality - with special reference to
      cases of pregnancy toxemias].

PMID- 1040691
TI  - [Operation of a midwife's office in cooperation with a city hospital. An example
      at Miss Haruko Suga's clinic at Yaizu].

PMID- 1040693
TI  - [Nutrition of expectant and puerperal patients].

PMID- 1040692
TI  - [Findings in the analysis of the amniotic fluid].

PMID- 1040694
TI  - [The curriculum at Kyoto University School of Midwifery].

PMID- 1040695
TI  - [Medical care in the Republic of Zaire].

PMID- 1040696
TI  - [Nursing in the intensive care unit and nursing training].

PMID- 1040697
TI  - [Nursing as a science with focus on the individual patient. Discussion].

PMID- 1040698
TI  - [AD (associate degree) challenge exams: 2 approaches. I. Testing knowledge and
      skills. II. A 4-part examination].

PMID- 1040699
TI  - [Study of nursing as an academic entity. IV. Nursing as a para-medical discipline
      in the system of medical care].

PMID- 1040700
TI  - [Educational methodology. Educational evaluation as part of teaching actions].

PMID- 1040701
TI  - [A trial in clinical training. IV. Training in the class room].

PMID- 1040702
TI  - [Nursing in literature. The helper and the helped - and example in "Minage
      Kyujogyo" by Kan Kikuchi].

PMID- 1040703
TI  - Controversial questions about breastfeeding.

PMID- 1040704
TI  - Assessing maternal attachment: first step toward the prevention of child abuse.

PMID- 1040705
TI  - An improved infant resuscitation cart for the delivery room.

PMID- 1040706
TI  - Psychologic involvement in pregnancy by expectant fathers.

PMID- 1040707
TI  - Attitudes of senior nursing students toward the 1973 Supreme Court decision on
      abortion.

PMID- 1040708
TI  - Hyperactivity: etiology and intervention techniques.

PMID- 1040709
TI  - Mental and emotional disturbances of school-age children. Preface.

PMID- 1040710
TI  - Disturbances of the preschool and very young school child.

PMID- 1040711
TI  - Mental and emotional disturbances of school-age children; the exceptional and
      middle school-age child.

PMID- 1040712
TI  - Mental and emotional disturbances of the secondary school-age student.

PMID- 1040713
TI  - A comprehensive approach to dental health in a school population.
AB  - A program to provide school children with dental health education and preventive
      services was initiated by the Boston University School of Graduate Dentistry.
      This program utilized several generally untapped resources. The emphasis was on
      classroom education using teachers who were motivated by special workshops as
      well as students of dental auxiliary training programs. These dental auxiliary
      students under the supervision of a dental health educator were used to educate
      the classroom teachers as well as to teach children in the classroom. Direct
      dental services were also provided in the program in the form of preventive
      services utilizing an unused dental chair available at a school.

PMID- 1040714
TI  - Schools with failure and alienation.

PMID- 1040715
TI  - 1974 Roering symposium: Intestinal parasite problems of school-age children.
      Introductory remarks.

PMID- 1040716
TI  - Common intestinal parasitic infections in the school-age population.

PMID- 1040717
TI  - Treatment of intestinal roundworm infections.

PMID- 1040718
TI  - The epidemiology of common intestinal helminths.

PMID- 1040719
TI  - 1974 Roerig symposium: Intestinal parasite problems of school-age children.
      Current school health programs.

PMID- 1040720
TI  - 1974 Roerig symposium: Intestinal parasite problems of school-age children.
      Assistance by state departments of education to local school districts.

PMID- 1040721
TI  - A comparison of experiential and traditional learning models in studying health
      problems of the poor.

PMID- 1040722
TI  - The challenge in leadership for nursing administration from the point of view of
      a charge sister.

PMID- 1040723
TI  - Services to people at work: medical, welfare and counselling.

PMID- 1040724
TI  - Selective and nonselective admissions criteria in junior college nursing
      programs.

PMID- 1040725
TI  - [Obesity and its treatment].

PMID- 1040726
TI  - [Ultrasonic diagnosis of eye diseases].

PMID- 1040727
TI  - [Medical gymnastics in diseases of the veins and lymphostasis of the legs].

PMID- 1040728
TI  - [Use of optic quantum generators (lasers) in clinical medicine].

PMID- 1040729
TI  - [Postgraduate training of paramedical personnel].

PMID- 1040730
TI  - [Scientific middle-level work organization at the polyclinic].

PMID- 1040731
TI  - [Propaganda of the current GTO (Industrial Health Organization) Complex].

PMID- 1040732
TI  - [Rational organization of preparations for student examinations].

PMID- 1040733
TI  - [Nurses - active participants of the antifascist organization].

PMID- 1040734
TI  - [Man's sensitivity to weather-meterological factors].

PMID- 1040735
TI  - [First aid in bone fractures].

PMID- 1040736
TI  - ,Surgical management of Dupuytren's contracture.

PMID- 1040737
TI  - [Conservative treatment of hemorrhoids and rectal fissures].

PMID- 1040738
TI  - [Prevention and treatment of postoperative thromboembolic complications].

PMID- 1040739
TI  - [Postinjection abscess].

PMID- 1040740
TI  - [Preoperative management and postoperative care of oncological patients].

PMID- 1040741
TI  - [Preoperative management and postoperative care of children in a urologic
      department].

PMID- 1040742
TI  - [Surgical treatment methods in acute purulent destructive lung lesions in
      children].

PMID- 1040744
TI  - [A method of medical gymnastics in injuries of the spinal cord].

PMID- 1040743
TI  - [Physical fractures in complex treatment of fractures].

PMID- 1040745
TI  - [Medical gymnastics in cervico-thoracic osteochondrosis].

PMID- 1040746
TI  - [Care of patients with acute cholecysto-pancreatitis].

PMID- 1040747
TI  - [Puncture catheterization of the subclavian vein].

PMID- 1040748
TI  - [Indwelling foreign body of the urinary bladder].

PMID- 1040749
TI  - [Gastric lavage using a vacuum aspirator].

PMID- 1040751
TI  - [Various technics of medical manipulation].

PMID- 1040750
TI  - [Use of iodinole in surgery].

PMID- 1040752
TI  - [Acute poisoning following erroneous administration of novocaine solution in an
      enema].

PMID- 1040753
TI  - [Emergency management of patients with acute diseases of the abdominal organs].

PMID- 1040754
TI  - Guidelines for teachers of parentcraft and relaxation. Resume and appendix.

PMID- 1040755
TI  - Antibiotic sensitivity of two Aeromonas and nine Pseudomonas species.
AB  - An agar dilution method was used to determine the in vitro sensitivity of
      different Pseudomonas and Aeromonas species to sulphonamide, tetracycline,
      colistin, gentamicin, tobramycin, amplicillin, carbenicillin, and cephalothin. P.
      aeruginosa was generally sensitive to carbenicillin, colistin, tobramycin, and
      gentamicin. P. putida and P. fluorescens were generally resistant to beta-lactam
      antibodies but sensitive to gentamicin and tobramycin. P. cepacia and P.
      maltophilia were mostly resistant to colistin, gentamicin and tobramycin. Other
      Pseudomonas species were usually more sensitive to the antibodies tested. Strains
      of Aeromonas hydrophila were mostly resistant to beta-lactam antibiotics but
      sensitive to other antibiotics, while strains of A. shigelloides were very
      sensitive to all antibiotics tested.

PMID- 1040756
TI  - Recognition, certification and accountability.

PMID- 1040757
TI  - On paying the fiddler to change the tune: further evidence from Ontario regarding
      the impace of universal health insurance on the organization and patterns of
      medical practice.
AB  - This paper compares the findings from a 1973 community household interview survey
      conducted in Sault Ste. Marie, Ontario, with the findings from a similar study
      conducted in 1968 in the same city by a research team from the World Health
      Organization. Sault Ste. Marie is the site of the first Canadian consumer
      sponsored prepaid group practice. Opposition by the private, solo practice sector
      of this community to this new modality of medical practice was considerable.
      Since 1969, with the introduction of universal health insurance in Ontario, the
      cost and benefit differences between solo and group practice medical care have
      been eliminated. By comparing the findings from the 1973 study with similar data
      from the 1968 WHO survey, observations can be made about the impact of universal
      health insurance on the organization and patterns of medical practice.
      Implications for the United States are important in view of the recent passage of
      the Health Maintenance Organization Act of 1973 and the expected enactment of
      some form of national health insurance.

PMID- 1040758
TI  - Factors affecting the choice between prepaid group practice and alternative
      insurance programs.
AB  - This paper examines the basis for the selection of prepaid group practice in a
      dual-choice situation, and the social, attitudinal, and health characteristics of
      populations choosing prepaid programs in contrast to other plans. When asked in
      an open-ended way why they made the decisions they did, those selecting prepaid
      group practice most frequently referred to the more comprehensive coverage
      provided and to the fact that at the time of choice they lacked a continuing or
      adequate relationship with a physician. Enrollees in the prepaid program were
      better educated and, contrary to previous research, more likely to be unmarried.
      There was little evidence that enrollees in the prepaid plan brought with them
      distinctive kinds of attitudes and orientations toward illness and medical care.
      Enrollees in the prepaid program were also comparable to those retaining an
      alternative health insurance option on a number of indicators of health status.
      However, prepaid practice enrollees tended to report more chronic conditions than
      persons who declined to enroll in the prepaid program. Although the
      overrepresentation of persons with chronic illnesses is not large, data drawn
      from a related study suggests that persons with several chronic conditions tend
      to be heavy users of medical services.

PMID- 1040759
TI  - Dental care and the health maintenance organization concept.
AB  - The principal dental diseases, caries and periodontal disease, affect almost the
      entire population and result in considerable pain and discomfort, with eventual
      tooth loss, if untreated. These disorders can either be prevented or their
      effects minimized through dental intervention so that intact functioning
      dentitions can be maintained. Despite the fact that enough practicing dentists
      probably exist in the United States to achieve these results, the majority of the
      population lose all of their natural teeth if they live out their normal life
      spans. The solo-practice fee-for-service system, even with third-party payment,
      may reduce the difficulties somewhat but cannot solve the problem. Prepaid dental
      group practice, either independently or as part of a general health care system,
      has the potential of virtually eliminating edentulism in populations for which it
      has responsibility. At present, it is possible to project costs and resource
      needs with sufficient accuracy to start viable entities. The "health maintenance
      organization" concept, therefore, applies to dental care.

PMID- 1040760
TI  - The pricing behavior of medical groups.
AB  - This study discusses a model of the pricing behavior of medical groups. Using
      data collected, by a mail survey, from medical groups in North Carolina, an
      empirical test of the model is performed. The results suggest that the prices
      charged by medical groups are positively influenced by the per capita income of
      the county in which the group is located, and the per physician utilization of
      medical, technical, and office personnel. They also suggest that for groups in
      the sample, a non-physician manager and a non-salaried system of remuneration to
      member physicians are negatively related to the price of medical services. The
      results of this study also indicate that the managerial structure of group
      practice is an important area for further research.

PMID- 1040761
TI  - The crying infant.

PMID- 1040762
TI  - In neo-natal ICU nursing: vive le difference.

PMID- 1040763
TI  - The school nurse--an obsolete professional revisited.

PMID- 1040764
TI  - How to plan a successful meeting.

PMID- 1040765
TI  - Parents care in intensive care.

PMID- 1040766
TI  - A child grows. Part II. How the child grows and develops psychologicall, socially
      and culturally.

PMID- 1040767
TI  - Ode on a strep throat.

PMID- 1040768
TI  - Tympanometry: a technique for identifying ear disease in children.

PMID- 1040769
TI  - The making of a PNA (pediatric nurse associate).

PMID- 1040770
TI  - The nurse and nursery planning.

PMID- 1040771
TI  - The utilization of nurses in expanded roles to deliver pediatric cardiology
      health care.

PMID- 1040772
TI  - The use of the pediatric nurse practitioner in comprehensive health care.

PMID- 1040773
TI  - A child grows. Part III. The child's cognitive development.

PMID- 1040775
TI  - The cost of nursing education. A preliminary report on methodological problems.
      Introduction.

PMID- 1040774
TI  - Perspectives for nursing. A report of the Committee on Perspectives.

PMID- 1040776
TI  - The cost of nursing education. A preliminary report on methodological problems.

PMID- 1040777
TI  - Political considerations in studying the costs of health professional education.

PMID- 1040778
TI  - The step-down method of cost accounting in diploma schools of nursing.

PMID- 1040779
TI  - The cost of non-nursing courses in nursing education.

PMID- 1040780
TI  - Research as a component in the cost of nursing education.

PMID- 1040781
TI  - The concept of full-time student equivalents.

PMID- 1040783
TI  - Some methodological problems in the IOM study of the costs of nursing education.

PMID- 1040782
TI  - Licensed practical nursing as a part of the cost of nursing education.

PMID- 1040784
TI  - Faculty-curriculum development. Part V. The changing role of the professional
      nurse--implications for nursing education.

PMID- 1040785
TI  - Three factors of significance to baccalaureate nursing education.

PMID- 1040786
TI  - Changes in community nursing service that affect baccalaureate nursing programs.

PMID- 1040788
TI  - Offering learning experiences that reflect the changing role of the professional
      nurse.

PMID- 1040787
TI  - Curriculum implications of the changing role of the professional nurse.

PMID- 1040789
TI  - Changes in nursing service that affect baccalaureate nursing programs.

PMID- 1040790
TI  - Faculty-curriculum development. Part VI. Curriculum revision in baccalaureate
      nursing education.

PMID- 1040791
TI  - Curriculum revision--the what, when, why, and who.

PMID- 1040792
TI  - The conceptual framework in nursing education.

PMID- 1040793
TI  - The development of behavioral objectives through curriculum strands.

PMID- 1040794
TI  - Curriculum design and approaches to nursing courses and content.

PMID- 1040795
TI  - Learning experiences within and outside the classroom.

PMID- 1040797
TI  - The philosophy as part of the total curriculum process.

PMID- 1040796
TI  - Some components of curriculum evaluation.

PMID- 1040798
TI  - The future of nursing education.

PMID- 1040799
TI  - Criteria for the evaluation of diploma programs in nursing.

PMID- 1040801
TI  - Providing a climate for the utilization of nursing personnel. Papers presented at
      the Joint Program of the National League for Nursing and the American Hospital
      Association, November, 1974, New York, NY.

PMID- 1040800
TI  - Characteristics of diploma education in nursing.

PMID- 1040802
TI  - Team health care - cliche or reality. The home health care program.

PMID- 1040803
TI  - Team health care - cliche or reality. Coordination of patient services among
      health team members.

PMID- 1040804
TI  - Climate to foster utilization of the nursing process.

PMID- 1040805
TI  - The effect of various climates in hospitals providing health care.

PMID- 1040806
TI  - Utilization of the baccalaureate graduate in the nursing process.

PMID- 1040807
TI  - Changing variables and their effect on the climate for nursing practice.

PMID- 1040808
TI  - Utilization of the diploma graduate in the nursing process.

PMID- 1040809
TI  - Utilization of the associate degree graduate in the nursing process.

PMID- 1040810
TI  - Utilization of the practical nurse in the nursing process.

PMID- 1040811
TI  - The climate to foster interpersonal relationships among health team members.
      Health team care - cliche or reality? The inpatient setting.

PMID- 1040812
TI  - Team health care - cliche or reality. The ambulatory care setting.

PMID- 1040813
TI  - Team health care - cliche or reality. The visiting nurse setting.

PMID- 1040814
TI  - Team health care - cliche or reality. The ambulatory care setting.

PMID- 1040815
TI  - Four approaches to staff development.

PMID- 1040816
TI  - The staff development program at the Tucson Medical Center.

PMID- 1040817
TI  - The staff development program in the Greenville Hospital System.

PMID- 1040818
TI  - The staff development program of Sinai Hospital of Detroit.

PMID- 1040819
TI  - The staff development program of the Mount Sinai Hospital, New York.

PMID- 1040820
TI  - The issue is leadership. Papers presented at the Annual Meeting of the Council of
      Home Health Agencies and Community Health Services, March 1974, Washington, D.C.

PMID- 1040821
TI  - A hospital without walls.

PMID- 1040822
TI  - The role of the public health nurse in hemodialysis.

PMID- 1040823
TI  - VNA approaches to discharge planning.

PMID- 1040825
TI  - Challenges in agency management.

PMID- 1040824
TI  - The challenge of reviving home health care.

PMID- 1040826
TI  - Challenges in agency management.

PMID- 1040827
TI  - Community health service agencies--programming for the future.

PMID- 1040828
TI  - Program development in the field of aging.

PMID- 1040829
TI  - Some observations on the use of nurse practitioners in community health nursing.

PMID- 1040830
TI  - Preparation of the primary care nurse.

PMID- 1040831
TI  - The clinical specialist in nursing.

PMID- 1040832
TI  - The issue is leadership.

PMID- 1040833
TI  - Accreditation and certification in the American Speech and Hearing Association.

PMID- 1040834
TI  - The homemaker-home health aide.

PMID- 1040835
TI  - A look at tomorrow's accreditation.

PMID- 1040836
TI  - The energy crunch and the health scene.

PMID- 1040837
TI  - Type, length, and cost of care for home health patients. A report of the
      discharge summary feasibility study.

PMID- 1040838
TI  - Where is nursing going? The Ruth V. Matheney memorial lecture presented at the
      1975 NLN Convention New Orleans, Louisiana.

PMID- 1040839
TI  - Quality assessment and patient care.

PMID- 1040840
TI  - Monitoring the quality of nursing care.

PMID- 1040841
TI  - Participation in a Department of Health, Education, and Welfare project.
      Monitoring patient care.

PMID- 1040842
TI  - Participation in a Department of Health, Education, and Welfare project; the
      quality control process.

PMID- 1040843
TI  - Selecting appropriate assessment measures in the community health agency.

PMID- 1040844
TI  - Selecting appropriate assessment measures in the institutional setting.

PMID- 1040845
TI  - Future goals and directions for nursing and the nursing service administrator.

PMID- 1040846
TI  - Outdate reversible update continuing education: who, what, where, when, how.
      Papers presented at the Conference of the Northeast Regional Assembly of
      Constituent Leagues New York, New York, November 1974.

PMID- 1040847
TI  - The implications of continuing education in nursing.

PMID- 1040848
TI  - Outdate--update. Continuing: who, what, where, when, how. The impact of peer
      review.

PMID- 1040849
TI  - Professional control of continuing education.

PMID- 1040850
TI  - The role of the hospital in continuing education.

PMID- 1040851
TI  - The National League for Nursing's role in continuing education.

PMID- 1040852
TI  - The origin and evolution of the continuing education unit.

PMID- 1040853
TI  - Case study in obstetrics.

PMID- 1040854
TI  - My first anniversary with the NFLPN.

PMID- 1040855
TI  - On the development and classification of diagnoses.
AB  - Nurses, as noted earlier, always have and are now using the five steps of the
      diagnosis process. This utilization is a valuable and essential element of a
      profession. On the other hand, conceptual analysis of the process suggests that
      all ten steps are necessary conditions for a natural history of nursing. Such a
      natural history would constitute a taxonomy of nursing diagnoses and would
      identify and codify essential concerns and associated nomenclatures which have
      been agreed upon by members of the profession. In turn, such an agreement would
      lead to a common universe of discourse for the clinicians, the students, the
      teachers, the administrators, and the researchers in nursing. A workable taxonomy
      would provide potential points of reference, purpose, and direction and would
      facilitate communication and collaboration in nursing practice, nursing
      education, and nursing research. Such a taxonomy would constitute a systematic
      ordering of the unique body of knowledge of nursing and would provide a
      foundation of level-one theory. On this basis could be built higher-level
      theories that are grounded in observable phenomena. This development, in turn,
      would create a bridge across the knowledge-practice gap and would allow more
      effective application of scientific knowledge to specific clinical patient-care
      and nursing problems. A workable taxonomy of nursing diagnoses would articulate
      areas of unique concern to nurses and nursing and would allow more unequivocal
      communication of the focus, limits, and nature of the realm of nursing to other
      professions, third-party payers, governmental agencies, and the public. Without
      the development of such a framework, nursing research will continue to flounder,
      nursing education will continue to lack articulation of ordered body of knowledge
      of nursing concerns and related cognitive and other competencies, and nursing
      practice will continue to drift toward the use of medical terminology and to
      focus on dependent and technical nursing functions and the extension of the role
      of the nurse in the domain of medicine. In short, the lack of a sound taxonomy of
      nursing diagnoses endangers the realm of independent functions of nursing--its
      care, comfort, and compassion for the person who suffers from illness, and its
      focus on increased patient self-help ability, self-determination, and health
      promotion.

PMID- 1040856
TI  - Stating educational objectives in behavioral terms.

PMID- 1040857
TI  - The editor's role.

PMID- 1040858
TI  - Human biorhythmology: implications for nursing practicel.

PMID- 1040859
TI  - Biofeedback training: the voluntary control of mind over body and mind.

PMID- 1040860
TI  - Euthanasia and the nurse practitioner.

PMID- 1040861
TI  - The menopause: facts anf misconceptions.

PMID- 1040862
TI  - Literature by consumers for nursing.

PMID- 1040863
TI  - Dying and death--and life experiences of loss and gain: a proposed theory.

PMID- 1040864
TI  - The woman in white.

PMID- 1040865
TI  - Diabetes--some important hints and the role of a nurse in its prevention and
      management.

PMID- 1040866
TI  - Feudal values in the modern Indian society.

PMID- 1040867
TI  - A case study: a peculiar ectopic pregnancy.

PMID- 1040868
TI  - Nurses' participation in patients' psychological problems.

PMID- 1040869
TI  - Male midwives.

PMID- 1040870
TI  - Rabies in perspective.

PMID- 1040871
TI  - Rural medicine: a new skill for the practice team in the countryside.

PMID- 1040872
TI  - HL-A 27 and arthritis.

PMID- 1040873
TI  - The algometer: as useful as the thermometer.

PMID- 1040874
TI  - Cervical cytology.

PMID- 1040875
TI  - The road back.

PMID- 1040876
TI  - Consequences of delaying claims for injuries in hospital.

PMID- 1040877
TI  - Management training - where now? (2).

PMID- 1040878
TI  - Nursing auxiliaries training in geriatric hospitals.

PMID- 1040880
TI  - An inconvenient fetus.

PMID- 1040879
TI  - The role of the voluntary agency in mental handicap.

PMID- 1040881
TI  - Not a special case.

PMID- 1040883
TI  - Time to talk.

PMID- 1040882
TI  - Research.

PMID- 1040884
TI  - Typhoid: will fear of this disease spoil your holiday?

PMID- 1040885
TI  - Major disaster procedure: the Birmingham bomb incidents.

PMID- 1040886
TI  - Ulcerative colitis.

PMID- 1040887
TI  - The nurse and research.

PMID- 1040888
TI  - Dynamic aspects in clinical learning. Part 1.

PMID- 1040889
TI  - A new maternity unit.

PMID- 1040890
TI  - The patient is a person.

PMID- 1040891
TI  - Editorial: A doctor's dilemma.

PMID- 1040892
TI  - Buy British?

PMID- 1040893
TI  - Nursing care study: determined to live.

PMID- 1040894
TI  - The artificial ear - research into cochlear implants.

PMID- 1040895
TI  - Teaching in the ward environment.

PMID- 1040896
TI  - Relief work in Kurdistan.

PMID- 1040897
TI  - Rawcliffe Hall - an appreciation of a geriatric hospital.

PMID- 1040898
TI  - Preparing for a richer, happier life.

PMID- 1040899
TI  - Dynamic aspects in clinical learning. Part 2.

PMID- 1040900
TI  - Study of nurses attitudes to aspects of nursing.

PMID- 1040901
TI  - Cardiocirculatory effects of morphine.

PMID- 1040902
TI  - Editorial: Hospital board finances.

PMID- 1040903
TI  - Problems affecting nursing and the health services.

PMID- 1040904
TI  - [Home care services; definition of the concept "home care"].

PMID- 1040906
TI  - [Hypertensive crisis].

PMID- 1040905
TI  - [Psychiatric activities: report of the first year's activities (3-1-72 - 3-1-73)
      of of the work of Sector V, West Turin].

PMID- 1040907
TI  - [Norms for the professional education of physiotherapists in Italy].

PMID- 1040908
TI  - [Outline concerning various modifications in the organization of the professional
      nursing school and a new program of instruction].

PMID- 1040909
TI  - [Remarks on the proposal for new qualifications in interruption of pregnancy].

PMID- 1040911
TI  - [The place of nurses in medicine].

PMID- 1040910
TI  - [Considerations about urinary infections].

PMID- 1040912
TI  - [Preparation for a profession].

PMID- 1040913
TI  - [Nursing care of small children].

PMID- 1040914
TI  - [Nursing studies].

PMID- 1040915
TI  - [The work of nurses in higher education].

PMID- 1040916
TI  - [The importance of vitamin "M"].

PMID- 1040917
TI  - [Arterial diseases of the lower extremity].

PMID- 1040918
TI  - [Nursing in oncology].

PMID- 1040919
TI  - [The place of nurses in medicine].

PMID- 1040920
TI  - [Professional attitude].

PMID- 1040921
TI  - [The hospitalized child].

PMID- 1040922
TI  - [Nursing Department of the Slask Academy of Medicine].

PMID- 1040923
TI  - [Master of Arts in nursing in prophylactic medicine].

PMID- 1040924
TI  - [Burns].

PMID- 1040925
TI  - [The contemporary nurse].

PMID- 1040926
TI  - [Just one conception].

PMID- 1040927
TI  - [Joint success].

PMID- 1040928
TI  - [Nursing the burn patient].

PMID- 1040929
TI  - [Diet for the burn patient].

PMID- 1040930
TI  - [Nursing in oncology].

PMID- 1040931
TI  - [The nursing counsel].

PMID- 1040932
TI  - The therapeutic value of work.

PMID- 1040933
TI  - The trouble with mental health legislation.

PMID- 1040934
TI  - Organizational problems in community psychiatric programs.

PMID- 1040935
TI  - The oxygen consumption, fatty acid and glycerol uptake of the liver in fed and
      fasted sheep during cold exposure.

PMID- 1040936
TI  - A pharmacological and histological investigation of the involvement of mast cells
      in cutaneous axon reflex vasodilatation.

PMID- 1040937
TI  - Utilization of amino acids by the isolated perfused sheep liver.
AB  - To test Elwyn's suggestion [1970], that high concentrations of amino acids
      supplied to the liver from the hepatic artery do not stimulate protein synthesis,
      substrates containing amino acids have been infused into either the hepatic
      artery or portal vein of isolated sheep livers. The livers received highly
      oxygenated blood from the hepatic artery and partly deoxygenated blood from the
      portal vein. There were no significant differences in amino acid uptake (81 +/-
      4% of input), urea output (69 +/- 6% of uptake) or 'protein synthesis' as
      assessed by N accumulation in the liver. Amino acids were actively extracted from
      the plasma by both routes of infusion and , when the concentrations simul-ted
      those occurring in the portal vein of fed sheep, the uptake was very similar to
      that in vivo. When an amino acid mixture based on that absorbed in dogs was
      infused, the extraction of individual amino acids was similar except for a
      negligible uptake of valine, leucine and isoleucine. In these experiments protein
      synthesis was also very low.

PMID- 1040938
TI  - Lacoferrin in rabbit bile: its relation to iron metabolism.
AB  - The relation of biliary lactoferrin concentration and the iron status of the body
      was studied in normal, anaemic and iron-loaded rabbits. In anaemic rabbits
      lactoferrin concentrations rose to two to three times the original values.
      Loading with iron resulted in a return to normal values. Mobilization of iron
      with desferrioxamine also gave a rise in lactoferrin concentration in bile.
      Lactoferrin may have a regulatory function in situations of enhanced iron
      absorption or mobilization of iron from depots.

PMID- 1040939
TI  - The influence of phentolamine on the hyperglycaemic and lipolytic effects of
      ammonia in sheep.
AB  - Intravenous infusion over 30 min of ammonium chloride [10-1 g/kg b.w.] caused a
      significant increase of blood glucose and free fatty acids levels, and a similar
      effect was observed with adrenaline. Phentolamine [1 mg/kg b.w.] abolished the
      hyperglycaemic action of ammonium chloride but only slightly diminished the
      lipolytic effect. It is concluded that the ammonium ion influences carbohydrate
      metabolism chiefly by way of catecholamines and stimulation of alpha-adrenergic
      receptors, while tissue lipids are mobilized by ammonia by another route,
      possibley directly.

PMID- 1040940
TI  - Administrative problems in union organizations.

PMID- 1040941
TI  - [The nursing process - foundation and application].

PMID- 1040942
TI  - [Petroleum as a source of food protein].

PMID- 1040943
TI  - [Objectives and values of the profession].

PMID- 1040944
TI  - [The hospital, its function in the community and the role of the public health
      nursing].

PMID- 1040946
TI  - [A philosophy of nursing. Will it be possible?].

PMID- 1040945
TI  - [Mobilization and elimination of bronchial secretion].

PMID- 1040947
TI  - [The need for a nursing concept].

PMID- 1040948
TI  - [Symptoms and treatment when formulas fail].

PMID- 1040949
TI  - [Nursing assistance to patients with a recent craniocerebral trauma].

PMID- 1040950
TI  - [Myths in nursing].

PMID- 1040951
TI  - [Various software of the subsystem of the operating room administration: policies
      and rules].

PMID- 1040952
TI  - [Nursing care in relation to the need of a self-image].

PMID- 1040953
TI  - [Variations in the results of pulse, respiration, and heart rate verified by
      double-blind method].

PMID- 1040954
TI  - [Orientation for planning an intensive course for auxiliary nursing
      subsidiaries].

PMID- 1040955
TI  - [Nursing care in a therapeutic community. I. Hospital organization and
      functioning].

PMID- 1040956
TI  - [An experience in teaching nursing of communicable diseases].

PMID- 1040957
TI  - [Bases for a nursing science].

PMID- 1040958
TI  - [A systemic approach to the binomial relationship, central supply and surgical
      center].

PMID- 1040959
TI  - [Nursing care evaluation].

PMID- 1040960
TI  - [Description of the global professional content of public health nursing
      subsidies].

PMID- 1040961
TI  - [Surgical center: a subsystem of the hospital macrosystem].

PMID- 1040962
TI  - [Nursing care in a therapeutic community. II. The competence of the psychiatric
      nursing attendants].

PMID- 1040963
TI  - [Humanization of services and the use of technology in health care].

PMID- 1040964
TI  - [The operating room nurse; pivot of the surgical unit].

PMID- 1040965
TI  - [The development of nuclear energy and medical application of ionizing radiation:
      their respective risks for man and his environment].

PMID- 1040966
TI  - [Functional studies of the nervous system. 2. Radioisotope studies and ultrasonic
      explorations].

PMID- 1040967
TI  - [Athletic injuries].

PMID- 1040968
TI  - [Aneurysm of the abdominal aorta].

PMID- 1040969
TI  - [Eruptive fevers in children].

PMID- 1040970
TI  - [Results of the questionnaire on programmed instruction].

PMID- 1040971
TI  - [Failure of communication, a natural defect or a cultural one?].

PMID- 1040972
TI  - [There are a million mentally handicapped in France].

PMID- 1040973
TI  - [The nurse and information systems, unknown and ignored].

PMID- 1040974
TI  - [Hysterosalpingography].

PMID- 1040975
TI  - [President's report].

PMID- 1040976
TI  - Achieving a low perinatal mortality rate in rural areas.

PMID- 1040977
TI  - [Low birth weight babies with emphasis on small-for-date babies].

PMID- 1040978
TI  - Hypoglycaemia--an important neonatal problem.

PMID- 1040979
TI  - [Apparatus and neonatal intensive care unit].

PMID- 1040980
TI  - Infant feeding: babies, breasts and bottles.

PMID- 1040981
TI  - Development of affection in children and the effect of separation from the
      mother.

PMID- 1040982
TI  - Rooming-in.

PMID- 1040983
TI  - Children at risk.

PMID- 1040984
TI  - [Current trends in management of idiopathic respiratory distress syndrome in
      newborn infants].

PMID- 1040985
TI  - The mother-infant relationship.

PMID- 1040986
TI  - [Early diagnosis of disorders in the human fetus].

PMID- 1040987
TI  - The priorities of perinatal care.

PMID- 1040988
TI  - [Respiratory distress in the newborn infant; hyaline membrane disease].

PMID- 1040989
TI  - A multimedia approach to education.

PMID- 1040991
TI  - Tara, the H. Moross Centre; problem families.

PMID- 1040990
TI  - [Various possible adaptation problems of student nurses].

PMID- 1040992
TI  - [Employee health behavior in Oulu University Central Hospital].

PMID- 1040993
TI  - [Roentgen contrast media: a general report on principles of application in
      roentgen diagnosis].

PMID- 1040994
TI  - [Nursses' status in today's health team].

PMID- 1040996
TI  - [Norwegian Nurse' Association's national meeting in Oslo, June 18-20, 1975].

PMID- 1040995
TI  - [Health visitor's functions. Preventive health care is an important link in
      health services].

PMID- 1040997
TI  - [Finnish families in the Sor-Varanger community. I. A study of life conditions,
      food habits, smoking habits, etc., in a Finnish population group].

PMID- 1040998
TI  - [Impressions from a course in Atlanta, USA: mother and child health and family
      planning].

PMID- 1040999
TI  - [Nurses' drug information: methyldopa].

PMID- 1041000
TI  - [Nurses and physicians on abortion: we treat hastily and thereby often cause
      illness].

PMID- 1041001
TI  - [Cardiac pacemaker treatment. 1. Various forms of pacemakers].

PMID- 1041002
TI  - [Responsibility for patients under transport to the hospital. Training of
      personnel for our ambulances].

PMID- 1041003
TI  - [Patient's book points out many essential matters].

PMID- 1041004
TI  - [Nurses' drug information: hypertension - antihypertensive agents].

PMID- 1041005
TI  - [Cardiac pacemaker treatment. 3. Nurses have many important functions].

PMID- 1041006
TI  - [Nursing research. Younger nurses leave their job more frequently than older
      ones].

PMID- 1041007
TI  - [Public health nurse in a rough district of northern Norway. Via skies with a
      baby scale in the rucksack].

PMID- 1041008
TI  - [The nurse is the central person in communication with the patient].

PMID- 1041009
TI  - [One should marvel at the results of research arrangements].

PMID- 1041010
TI  - [Study of schools' sales from canteens and shops: every 6th school continually
      sells unwholesome food and beverages].

PMID- 1041011
TI  - [Study of 100 ambulatory patients points out: most want to help along in the
      wards].

PMID- 1041012
TI  - [Heart ambulances - their equipment and application possibilities; Heart
      ambulances; a new role for the nurse].

PMID- 1041013
TI  - [Comments from the Danish Nursing Council on reflections about a new basic
      nursing education: in general, the Danish Nursing council is in accord with these
      reflections].

PMID- 1041014
TI  - [The entire family should be guided into giving the newborn infant an optimal
      start].

PMID- 1041015
TI  - [They look after patients in the waiting room].

PMID- 1041016
TI  - [Pre and postoperative care of children with kidney diseases: even children need
      honest answers in language they can understood].

PMID- 1041017
TI  - [Roentgen studies in children with kidney diseases: they can be performed in all
      children regardless of age].

PMID- 1041018
TI  - [Nurses' drug information: hypertension - antihypertensive agents. 2].

PMID- 1041019
TI  - [The nurse and preventive cardiology: it is possible to prevent early heart
      mortality].

PMID- 1041020
TI  - [Nurse in an Icelandic area: roads to the hospital go up and down the highest
      mountain passes].

PMID- 1041021
TI  - [Public health nurse holds mothers' day once a month].

PMID- 1041022
TI  - [Physical rehabilitation of patients with myocardial infarct: the nurse can
      encourage to do more exercises].

PMID- 1041023
TI  - [3 nurses in a vacation job in an isolated region of North Norway: for a short
      period of time the hospital was entirely without anesthesia personnel].

PMID- 1041024
TI  - [How can one plan instruction which has its starting point in practice: education
      planning can consist of a number of practice fields].

PMID- 1041025
TI  - [This is how to plan instruction which has its startingpoint in practice: the use
      of a teaching model which gives increased motivation].

PMID- 1041026
TI  - [Nurses' drug information: hypertension - antihypertensive agents. 3].

PMID- 1041027
TI  - [The practicing physician and acute heart disease].

PMID- 1041028
TI  - [This way one can integrate primary health care in basic education: public health
      nursing ought to the ideology behind our education].

PMID- 1041029
TI  - [How to integrate primary health care in basic education: we must be more aware
      of normal human health].

PMID- 1041030
TI  - [Co-operation is lacking].

PMID- 1041031
TI  - [3 periods of clinical study of uropepsin test].

PMID- 1041033
TI  - [How can we solve the "aged explosion"?].

PMID- 1041032
TI  - [Nursing care or leisure activities - what do we want for the future?].

PMID- 1041034
TI  - [Does private health care infringe upon public care?].

PMID- 1041035
TI  - [Patients' needs should dictate research].

PMID- 1041037
TI  - [Perspective of the future].

PMID- 1041036
TI  - [Nursing shortage remains chronic].

PMID- 1041038
TI  - [Mental health services or humane care in Sweden today].

PMID- 1041039
TI  - [County Association's congress discusses future health care].

PMID- 1041040
TI  - [SI-system (Systeme Internationale) changes a lot in health care].

PMID- 1041041
TI  - [Health and nursing care legislation will be reformed].

PMID- 1041042
TI  - [How actively should counties work for equality?].

PMID- 1041043
TI  - [Organizational development - a method for changing nursing schools?].

PMID- 1041044
TI  - [Nursing process].

PMID- 1041046
TI  - [Nursing education as a part of health care and nursing science, science of Homo
      Patients].

PMID- 1041045
TI  - [Symposium in Helsingfors; September 27-29, 1974. Scientific philosophy].

PMID- 1041047
TI  - [Observations on nursing research].

PMID- 1041048
TI  - [Scandinavian health care and nursing research - a fact].

PMID- 1041049
TI  - [Nursing care of burn patients].

PMID- 1041050
TI  - [The use of splints in patients with burns].

PMID- 1041051
TI  - [Remarks on paraplegia].

PMID- 1041052
TI  - [Experimental nursing schools and their future perspective].

PMID- 1041053
TI  - [Quality in nursing. Is humane assistance attainable?].

PMID- 1041054
TI  - [Information from the clinical chemical laboratory].

PMID- 1041055
TI  - [Social skills in the job situation].

PMID- 1041056
TI  - [Methodology training in nursing education].

PMID- 1041057
TI  - [Paraplegia. III. Sexuality in paraplegics].

PMID- 1041059
TI  - [Information from the clinical chemical laboratory].

PMID- 1041058
TI  - [The changed professional role of the social psychiatric nurse].

PMID- 1041060
TI  - [Functioning of the works council in a hospital in Amsterdam].

PMID- 1041061
TI  - Euthanasia: Royal Victorian College of Nursing policy.

PMID- 1041062
TI  - The family practice nurse.

PMID- 1041063
TI  - Statement on a patient's bill of rights.

PMID- 1041064
TI  - How the Wages Board operates.

PMID- 1041065
TI  - Ultrastructural studies of hemangiosarcoma in a dog.

PMID- 1041066
TI  - Modification of the Ayre's "T" non-rebreathing system for monitoring respiratory
      sounds in anesthetized animals.

PMID- 1041067
TI  - Bicornuate uterine prolapse in a cat/ a photographic essay.

PMID- 1041068
TI  - Phosphate uroliths in a Dachshund.

PMID- 1041069
TI  - Latrogenic calcinosis cutis in a dog.

PMID- 1041070
TI  - Vaginal cytology an approach of improvement of cat breeding.

PMID- 1041071
TI  - Repair of enamel hypoplasia in the dog.

PMID- 1041072
TI  - Use of flea antigen in treatment of feline flea-allergy dermatitis.

PMID- 1041073
TI  - Use of the arthroscope in the horse.

PMID- 1041074
TI  - Micronema deletrix in the brain of a horse.

PMID- 1041075
TI  - The azoturia tying-up syndrome.

PMID- 1041076
TI  - Artificial rearing of lambs.

PMID- 1041077
TI  - Immunity fo tge transmissible gastroenteritis.

PMID- 1041078
TI  - Is the omentum really necessary?

PMID- 1041079
TI  - Cnemidocoptic mange in parakeets.

PMID- 1041080
TI  - Retinal arteriolar macroaneurysms in a Beagle dog: a photographic illustration of
      intravitreal hemorrhage from the rupture of pulsatile aneurysms.

PMID- 1041082
TI  - Don't be squeezed out of your practice.

PMID- 1041081
TI  - Follicular conjunctivitis confined to the pigmented conjunctiva in a Chow-Chow
      dog.

PMID- 1041083
TI  - How the new tax will affect you.

PMID- 1041084
TI  - The euthanasia dilemma.

PMID- 1041085
TI  - Cytologic differentiation of inflammation from neoplasia.

PMID- 1041086
TI  - Leptospira hardjo infection in a dairy herd.

PMID- 1041087
TI  - Botulism.

PMID- 1041088
TI  - The in vitro sensitivity of antibiotic-resistant bacteria to intramammary
      antibiotic preparations.

PMID- 1041089
TI  - Swine parasites: causes of liver condemnations.

PMID- 1041090
TI  - Pseudo-rabies in swine.

PMID- 1041091
TI  - Multiple ureteral defects in a Belgian foal.

PMID- 1041092
TI  - An equine eye shield.

PMID- 1041093
TI  - A simple, portable small animal anesthetic system using a disposable rebreathing
      system.

PMID- 1041094
TI  - A case study: dysphagia from retained ingested string.

PMID- 1041095
TI  - A simple surgical treatment for acute periodontitis in the dog.

PMID- 1041096
TI  - Masticator myopathy in the dog. (A review of two cases).

PMID- 1041097
TI  - Bilateral coxofemoral luxation in a dog after long-term estrogen therapy.

PMID- 1041098
TI  - Spontaneous remission of feline benign mammary hypertrophy.

PMID- 1041099
TI  - A technique for repair of colles' fractures.

PMID- 1041100
TI  - Clinical observations on lung flukes in the cat.

PMID- 1041101
TI  - Surgery required in treatment of glossitis.

PMID- 1041102
TI  - Scotopic blindness with coincidental nerve-head melanosis in a German Shepherd
      dog.

PMID- 1041103
TI  - Pancreatic amyloidosis with subsequent diabetes mellitus in an ocelot.

PMID- 1041105
TI  - Personality clashes in group practice.

PMID- 1041104
TI  - Incorporation & Keogh Funding. Effects on the sole owner of a practice.

PMID- 1041106
TI  - [Stages of research in nursing].

PMID- 1041107
TI  - [You have pain? I think this will help].

PMID- 1041108
TI  - [Research results on the healthy aged. Are there character and intelligence
      changes in the aged?].

PMID- 1041109
TI  - [Parttime employment in the hospital. Various aspects explained from the
      hospital's point of view, based on an inquiry of married nurses, by the VD/VS
      Section of the Swiss Registered Nurses' Association].

PMID- 1041110
TI  - [Goal setting in nursing service].

PMID- 1041111
TI  - [Legal problems related to contract-type employment treated from the aspect of
      contracts established for nursing personnel].

PMID- 1041112
TI  - [Swiss placement bureau for foreign nursing personnel].

PMID- 1041113
TI  - [Measurement of the nursing work load].

PMID- 1041115
TI  - [The scope and terminology of nursing].

PMID- 1041114
TI  - [Practical experience in the measuring of nursing work load].

PMID- 1041116
TI  - [Treatment of the skin in elderly patients at home and in homes for pensioners].

PMID- 1041117
TI  - [Relationship between science and information].

PMID- 1041118
TI  - [Current activities in the policlinic of Ostrava Hospital].

PMID- 1041119
TI  - [Principles in the first aid competition for students in secondary medical
      school].

PMID- 1041120
TI  - [Apparatus and equipment of the coronary unit].

PMID- 1041121
TI  - [First camp for phenylketonuric children in Czechoslovakia].

PMID- 1041122
TI  - [Management of district national medical care].

PMID- 1041123
TI  - [Psychological activities with infants at the maternity house].

PMID- 1041125
TI  - [Clinical enzymology in daily diagnostic work].

PMID- 1041124
TI  - [Useful drug therapy and correct handling of drugs and other medical supplies].

PMID- 1041126
TI  - [Health teams doing more than their duty].

PMID- 1041127
TI  - [Health and educational activities of nurses in the prevention of heart disease].

PMID- 1041128
TI  - [Free fluid in the abdominal cavity].

PMID- 1041129
TI  - [The nurse and the dental outpatient department].

PMID- 1041130
TI  - [Industrial injuries of women and youth in Czechoslovakia].

PMID- 1041131
TI  - [Useful drug therapy and correct handling of drugs and other medical supplies].

PMID- 1041132
TI  - [Women's struggle for equal rights in the USA].

PMID- 1041133
TI  - [Abdominal puncture with lavage and its significance in differential diagnosis of
      abdominal injuries].

PMID- 1041134
TI  - [Postgraduate education in anesthesia, resuscitation and intensive therapy].

PMID- 1041135
TI  - [Screening of chronic defects in children].

PMID- 1041136
TI  - [Effects of corrective posture and corrective movements on the development and
      growth of external pelvic dimensions].

PMID- 1041137
TI  - [Patients' observations following myocardial infarct].

PMID- 1041139
TI  - [Current information on vitamin C].

PMID- 1041138
TI  - [Experience of home care service nurses in visiting elderly and chronic
      patients].

PMID- 1041140
TI  - A case of priapism.

PMID- 1041141
TI  - Bilharzia - the complications.

PMID- 1041142
TI  - [The bacteriological diagnosis of vibrio fetus infection in man (author's
      transl)].
AB  - A synopsis of the present classification of Vibrio fetus is given (tab. 1, 2).
      Besides the presentation of the importance of these bacteria in veterinary
      medicine, 97 human infections have been published up to now. The geographic, age
      and sex distribution of these cases and the material out of which the pathogens
      were isolated is presented (tab. 3, 4). The clinical picture is summarized. For
      the culture of Vibrio fetus liver broth as described by TAROZZI incubated for at
      least 3-4 days was suitable as enrichment medium. The necessity of a prolonged
      incubation period was shown by results of continous registration of the optical
      density of growing Vibrio fetus cultures (fig. 1). If specimen is plated out on
      solid culture media before enrichment, the suitable media are chocolate agar,
      brain-heart infusion and Bacto-tryptose agar. For subcultures the DST-agar is
      also useful. Solid media cultures should be incubated microaerobically with 10%
      CO2 added. The resistance to Cephalothin of Vibrio fetus can be applied for
      selection on solid culture media. The metabolic activities of different Vibrio
      fetus biotypes were compared. A hitherto not reported metabolic activity, the
      hydrolysis of palmitic acid ester, is described (tab. 5). In the tube dilution
      test Vibrio fetus strains were sensitive to Gentamycin, Streptomycin, Ampicillin,
      Ciclacillin and Carbenicillin. They were resistent to Penicillin G, Cephalotin
      and Sulfonamid and showed borderline sensitivities to Tetracyclin, Kanamycin and
      Chloramphenicol (tab. 6).

PMID- 1041143
TI  - Morphine revisited in pediatric anesthesia.

PMID- 1041144
TI  - A pharmacologic evaluation of local anesthesia.

PMID- 1041145
TI  - Health care services in 1975--system or nonsystem?

PMID- 1041146
TI  - A case study: anesthetic considerations for pulmonary lavage.

PMID- 1041147
TI  - The laws covering malpractice--how they affect you.

PMID- 1041148
TI  - Editorial: The rapid expansion of medical knowledge and technology.

PMID- 1041149
TI  - Something new at Hopkins: the E.M.I.

PMID- 1041150
TI  - Pulmonary artery catheters.

PMID- 1041151
TI  - Changing trends in neurosurgical nursing.

PMID- 1041152
TI  - Components of a nursing program for patients in chronic pain.

PMID- 1041153
TI  - Update on the B.S.N. program.

PMID- 1041154
TI  - Editorial: Securing licensure.

PMID- 1041155
TI  - Peripheral pulses.

PMID- 1041156
TI  - Diet in pregnancy: meddling with the normal or preventing toxemia.

PMID- 1041157
TI  - Nursing by telephone.

PMID- 1041158
TI  - Re-thinking stroke: aphasic patients talk back.

PMID- 1041159
TI  - Re-thinking stroke: soft or hard devices to position hands?

PMID- 1041160
TI  - Re-thinking stroke: autumn months, autumn years.

PMID- 1041161
TI  - Nurse-physician relationships.

PMID- 1041162
TI  - Early diagnosis of acute angle-closure glaucoma.

PMID- 1041163
TI  - Nurse-managed care for psychiatric patients.

PMID- 1041164
TI  - Caring for the child with familial dysautonomia.

PMID- 1041165
TI  - Students meet the migrants.

PMID- 1041166
TI  - A plea for sex education in nursing curriculums.

PMID- 1041167
TI  - The sick role in patient care.

PMID- 1041168
TI  - Adolescent retardates in a therapy group.

PMID- 1041169
TI  - What a 12-hour shift offers.

PMID- 1041170
TI  - Getting a bill through Congress.

PMID- 1041171
TI  - ANA in the nation's capital.

PMID- 1041172
TI  - Watching your finances: what financial facts should a wife know?

PMID- 1041173
TI  - Editorial: It's vent-my-spleen time.

PMID- 1041174
TI  - Assessing trauma in the rape victim.

PMID- 1041175
TI  - Percutaneous renal biopsy.

PMID- 1041176
TI  - The maternal-child nurse practitioner.

PMID- 1041177
TI  - Phenylketonuria.

PMID- 1041178
TI  - Assessing a patient's hydration status.

PMID- 1041179
TI  - Dying with dignity at home.

PMID- 1041180
TI  - Five become a team in Appalachia.

PMID- 1041181
TI  - Crisis intervention before cardiac surgery.

PMID- 1041182
TI  - Promoting an independent nurse practice.

PMID- 1041183
TI  - Coping mechanisms for the working mother.

PMID- 1041184
TI  - Classes to improve diabetic self-care.

PMID- 1041185
TI  - Sex, intimacy and aging.

PMID- 1041186
TI  - Having a baby in Finland.

PMID- 1041187
TI  - Pastoral roles in presurgical visits.

PMID- 1041188
TI  - Computerized axial tomography of the brain: a new diagnostic tool.

PMID- 1041189
TI  - Screening for cervical cancer.

PMID- 1041190
TI  - A new approach to parenteral drug administration.

PMID- 1041191
TI  - Stomatitis after chemotherapy.

PMID- 1041192
TI  - What contributes to hope in the cancer patient?

PMID- 1041193
TI  - Need help in managing money?

PMID- 1041194
TI  - Transversal and longitudinal lecithin-sphingomyelin ratios in amniotic and lung
      fluids of fetal lambs.
AB  - Lecithin-sphingomyelin (L/S) ratios were measured in both amniotic and in lung
      fluids of fetal lambs. Around Day 130 of fetal age sudden increase of L/S ratio
      appeared in lung fluid. The amniotic L/S ratio increased only slowly as a
      consequence of which false negative values were obtained. A respiratory distress
      syndrome is to be expected when the lung fluid shows a L/S ratio less than 2. The
      L/S ratio of lung fluid is preferable to amniotic L/S ratio. In comparison with
      those of amniotic fluid the L/S ratios of lung fluid were significantly higher.
      Lung fluid secretion was measured daily. Large differences were seen among the
      lambs. Two days before delivery a striking decrease in the quantity of lung fluid
      production was noticed in all aminals.

PMID- 1041195
TI  - Summary proceedings ANA House of Delegates. American Nurses' Association 49th
      Convention; June 9-14, 1974. Civic Auditorium, Brooks Hall, San Francisco,
      California. No. G-117.

PMID- 1041196
TI  - Standards for continuing education in nursing. No. COE-8.

PMID- 1041197
TI  - Human rights guidelines for nurses in clinical and other research. No. D-46.

PMID- 1041199
TI  - Building for the future. No. NP-47.

PMID- 1041198
TI  - American Nurses' Association standards for nursing education. No. NE.-1.

PMID- 1041200
TI  - Origin, purpose, and thrust of the National Joint Practice Commission. No. NP-47.

PMID- 1041201
TI  - Family therapy: a therapeutic vehicle for all families. No. NP-47.

PMID- 1041202
TI  - Legal problems stemming from the nurse and medical practice acts. No. NP-47.

PMID- 1041203
TI  - Interdisciplinary education for nurses in the expanded role: the way of the
      future. No. NP-47.

PMID- 1041204
TI  - Michigan's experience in the early and periodic screening, diagnosis, and
      treatment program. No. NP-47.

PMID- 1041205
TI  - The nurse's involvement in legislation and public relations. No. NP-47.

PMID- 1041206
TI  - Nursing service directors' role. Mastering politics vital.

PMID- 1041207
TI  - Nursing service directors' role. Nursing administrator must be chief initiator of
      needed change.

PMID- 1041208
TI  - Nursing service directors' role. Position offers challenges, opportunities.

PMID- 1041209
TI  - Nursing service directors' role. Consultant's role must be clearly defined.

PMID- 1041210
TI  - Nurse administrators profiled: big job, low pay.

PMID- 1041211
TI  - Collective action - a nursing service director's perspective.

PMID- 1041212
TI  - Nursing service directors' role. Management tools needed.

PMID- 1041213
TI  - Nursing service directors' role. Responsibilities loom large.

PMID- 1041214
TI  - Letter: Shigella infection and antibiotic resistance.

PMID- 1041215
TI  - In vitro activity of penicillins against anaerobes.
AB  - The in vitro susceptibility of 162 anaerobic isolates from clinical material were
      tested to pencillin G, BL-P1654, and carbenicillin. Penicillin G and BL-P1654
      showed good activity against Bacteroides fragilis, but only 60% of strains were
      susceptible to carbenicillin at achievable blood levels (128 mug/ml).

PMID- 1041216
TI  - BL-P1654: a bacteriostatic penicillin?
AB  - In tube dilution studies, large discrepancies between inhibitory and bactericidal
      concentrations of BL-P1654 against Pseudomonas were observed. To explain these
      discrepancies which were not observed with carbenicillin, the kinetics of
      bacterial killing by these two penicillins were evaluated and compared. The
      kinetics of bacterial killing by both antimicrobial agents were characteristic of
      a penicillin, with killing initiating simultaneously with growth. Kill curves
      revealed the presence of a small number of cells resistant to BL-P1654 which were
      not detectable macroscopically. Studies on microbial resistance also showed the
      presence of a small but consistent number of cells resistant to BL-P1654 over a
      broad range of concentrations above its minimal inhibitory concentration. This
      pattern of resistance was not observed with carbenicillin. Thus, the
      discrepancies between inhibitory and bactericidal concentrations of BL-P1654 were
      not due to any unusual bacteriostatic activity but rather due to a small number
      of resistant cells whose presence could be detected only by sensitive
      subculturing techniques.

PMID- 1041217
TI  - Assessment of susceptibility of ampicillin-resistant enterobacteria to
      cephalosporins.
AB  - The susceptibility of 103 ampicillin-resistant strains of enterobacteria to two
      cephalosporins was assessed by turbidimetric monitoring and disk diffusion tests.
      The results obtained suggest that in most cases a correlation exists between the
      suppression of growth of a dense bacterial culture for a therapeutically
      acceptable period by a fixed, high concentration of cephalosporin and a large
      zone of inhibition (>/=24 mm) using a high potency disk. This correlation was
      found to hold good when a moderate, subconfluent inoculum and commercially
      obtained blood-agar plates were used for the disk test, but not when the
      stringent conditions required by the Kirby-Bauer test (which demands a dense
      inoculum on Mueller-Hinton agar) were employed. Better correlation was obtained
      with cephaloridine than with cephalothin. This approach to the interpretation of
      disk diffusion tests gives a grossly different picture of the susceptibility of
      ampicillin-resistant enterobacteria to cephalosporins than do conventional
      minimal inhibitory concentration-based correlations.

PMID- 1041218
TI  - In vivo protection of Fusobacterium necrophorum from penicillin by Bacteroides
      fragilis.
AB  - A mixed infection of Bacteroides fragilis and Fusobacterium necrophorum was
      resistant to treatment with penicillin even though a pure F. necrophorum
      infection could be successfully treated with penicillin. Since B. fragilis alone
      did not produce infection, these results indicate that B. fragilis can protect F.
      necrophorum from penicillin in vivo. The extent of protection afforded by a
      strain of B. fragilis was related to its level of resistance to penicillin. Only
      a few cells of B. fragilis were required in the initial bacterial injection.
      Moreover, protection was demonstrated when B. fragilis cells were injected as
      late as 24 h after the F. necrophorum cells. Protection of F. necrophorum from
      penicillin by B. fragilis was also demonstrated in vitro.

PMID- 1041219
TI  - Editorial: What price quality assurance?

PMID- 1041220
TI  - Forces influence move toward nursing diagnoses.

PMID- 1041222
TI  - Quality assurance in nursing.

PMID- 1041221
TI  - PSROs' background and perspective.

PMID- 1041223
TI  - JCAH patient care audit.

PMID- 1041224
TI  - Direct observation tool.

PMID- 1041225
TI  - A sample quality assurance checklist.

PMID- 1041227
TI  - CDC (Center for Disease Control) outlines handwashing practices.

PMID- 1041226
TI  - Penile prosthesis in impotence.

PMID- 1041228
TI  - Current concepts, head and neck cancer surgery.

PMID- 1041229
TI  - Mesh repair of abdominal wound dehiscence.

PMID- 1041230
TI  - Minocycline in staphylococcal soft-tissue infections.
AB  - Fifteen patients who had severe Staphylococcus aureus infections were treated
      with minocycline for 6 to 24 days; all responded satisfactorily. Where possible,
      posttherapy cultures were taken, and in all instances, the pathogen was
      eradicated. There was no adverse reactions. Minocycline proved to be an
      acceptable and effective alternative for staphylococcal soft-tissue infections.
      It has the following advantages: (1) it is administered orally on a twice-daily
      dosage schedule, which facilitates patient compliance; (2) its toxicity is well
      defined and is not troublesome during short-term therapy; and (3) it penetrates
      tissues in therapeutic amounts and yields serum levels that are well above the
      minimum inhibitory concentrations of most staphylococci.

PMID- 1041231
TI  - Is there no place like 'Home'?

PMID- 1041232
TI  - The importance of seeing the whole picture.

PMID- 1041233
TI  - Australia, health issues and nursing.

PMID- 1041234
TI  - How can the vision of Janus help professional nursing?

PMID- 1041235
TI  - Planning the teaching staff for schools of nursing.

PMID- 1041236
TI  - Structural equivalents of latency for lysosome hydrolases.
AB  - 1. Structure-linked latency, a trait for most lysosome hydrolase activities, is
      customarily ascribed to the permeability-barrier function performed by the
      particle-limiting membrane, which shields enzyme sites from externally added
      substrates. 2. The influence of various substrate concentrations on the reaction
      rate has been measured for both free (non-latent) and total (completely unmasked
      by Triton X-100) hydrolase activities in rat liver cell-free preparations. The
      substrates were: beta-glycerophosphate, phenolphthalein mono-beta-glucuronide. p
      nitrophenyl N-acetyl-beta-D-glucosaminide and p-nitrophenyl beta-D
      galactopyranoside. The ratio (free activity/total activity) X 100 is called
      fractional free activity at any given substrate concentration. 3. The fractional
      free activity of beta-glucuronidase and beta-N-acetylglucosaminidase were clearly
      independent of substrate concentration, over the range examined, in both
      homogenates and lysosome-rich fractions. The fractional free activity of acid
      phosphatase appeared to be either unaffected (homogenate) or even depressed
      (lysosome-rich fraction) by increasing the beta-glycerophosphate concentration.
      The fractional free activity of beta-galactosidase consistently showed a non
      linear increase with increasing substrate concentration in both homogenates and
      lysosome-rich fractions. 4. Procedures such as treatment with digitonin, hypo
      osmotic shock and acid autolysis, although effective in causing varying degrees
      of resolution of the latency of lysosome hydrolase activities, were unable to
      modify appreciably the pattern of dependence or independence of their fractional
      free activities on substrate concentration, as compared with that exhibited by
      control preparations. Ouabain did not affect the free beta-N
      acetylglucosaminidase activity of liver homogenates at all. 5. Preincubation of
      control preparations with beta-glycerophosphate or p-nitrophenyl beta-galactoside
      did not result in any significant stimulation of the free hydrolytic activity
      toward these substrates. 6. The results consistently support the view that the
      membrane of "intact" lysosomes is virtually impermeable to all the substrates
      tested, except for p-nitrophenyl beta-galactoside, for which the evidence is
      contradictory. Moreover the progressive unmasking of the hydrolase activities
      produced by these procedures in vitro reflects the increasing proportion of
      enzyme sites that are fully accessible to their substrates rather than a graded
      increase in the permeability of the lysosomal membrane.

PMID- 1041237
TI  - Patterns of the drug habit in hospitalized psychiatric patients.

PMID- 1041238
TI  - Six years of cross-sectional surveys of student drug use in Toronto.

PMID- 1041239
TI  - Responses of poppy, Papaver somniferum, to photoperiod.

PMID- 1041240
TI  - A simple sensitive specific field test for cocaine based on the recognition of
      the odour of methyl benzoate as a test product.

PMID- 1041241
TI  - A simple method for the determination of dependence-producing drugs by gas
      chromatography.

PMID- 1041242
TI  - The ionic channels in excitable membranes.
AB  - The ionic channels in excitable membranes are of two classes: those that open and
      close when the membrane potential alters and those that respond to the release of
      an appropriate chemical transmitter. The former are responsible for the
      conduction of impulses in nerve and muscle fibres and the latter for synaptic
      transmission. It is now clear that the sodium and potassium channels in
      electrically excitable membranes are functionally distinct, since each can be
      blocked without affecting the behaviour of the other. It has recently proved
      possible to study, in the voltage-clamped squid giant axon, the movements of the
      mobile charges or dipoles that form the voltage-sensitive portion of the sodium
      channels, which give rise to the so-called 'gating' current. Detailed comparisons
      can now be made between the kinetics of the ionic conductances as described by
      Hodgkin & Huxley, and the steady-state distribution and kinetics of the charged
      controlling particles, which should lead to useful conclusions about the
      intramolecular organization of the sodium channels and the conformational changes
      that take place under the influence of the electric field. There is as yet little
      information about the chemical nature of the electrically excitable channels, but
      significant progress has been made towards the isolation and characterization of
      the acetylcholine receptors in muscle and electric organ.

PMID- 1041243
TI  - Spasmonemes, a new contractile system.

PMID- 1041244
TI  - How does ATP act as an energy source?
AB  - Two misleading conclusions drawn from the classical treatment of thermodynamics
      are, first, that single molecules cannot be treated thermodynamically and,
      second, that all real processes must be irreversible. The first conclusion has
      meant that the disruptive effect of thermal motions has been ignored, the second
      has meant that dynamic forces which cannot exist without stored energy, have been
      left out of account. The effect of these beliefs is demonstrated by analysis in
      detail of a simple electrostatic model of muscle. It is shown that the necessity
      of protecting each step against decay of the stored energy, and the requirement
      that each should be specific, has the effect of stopping the model actually
      working. Moreover, the character of static forces, which are strongest after
      their stored energy has been used up, precludes their use in cyclic processes
      because as much stored energy is required to undo them later in the cycle.
      Covalent intermediates are also examined from a quantum mechanical viewpoint and
      it is shown how these store energy which can be transferred by resonant
      transitions in the ground state when groups like phosphate are transferred
      chemically between molecules. But this analysis shows that, necessarily, the
      energy remains stored and therefore not available for muscular contraction. Then
      it follows naturally both that bond vibrations are produced in exothermic
      chemical reactions and that, because the force disappears when the energy has
      been used up, resonant exchange of stored energy in the excited state should
      solve the difficulties of previous approaches to these problems.

PMID- 1041245
TI  - Muscle as a thermodynamic machine.
AB  - Three main problems in the energetics of muscular contraction confront us at the
      present time:- (1) Thermodynamics. This is a labyrinthine subject in the sense
      that there are often several equally correct ways (that may appear different) of
      arriving at the same result. The recent advances in the kinetics of the reactions
      of muscle proteins have increased still further the need for understanding among
      muscle physiologists-and other biologists-of those parts of thermodynamics that
      concern them directly, notably those relating work and chemical change. (2)
      Energy balance. Over the whole cycle of contraction, relaxation and oxidative
      recovery, the observed energy output (heat + work) can be accounted for by the
      chemical processes currently believed to operate in the cycle. In contrast,
      during contraction and relaxation alone, the energy output is greater than can be
      accounted for by the extent of known chemical reactions combined with their heats
      of reaction (measured calorimetrically). The physical and chemical methods cross
      check one another-hence the usefulness of the method. The details of this
      discrepancy may vary from species to species but it is seen in all the
      experiments known at this time. The general problem will be resolved only when we
      know more about the chemical reactions that have occurred and reliable
      measurements have been made of their heats of reaction in vitro. (3) Work
      balance. Work and heat differ thermodynamically and, since the production of work
      is a primary function of muscles, the question naturally arises whether the
      observed splitting of ATP (combined with estimates of the change in free energy
      of this reaction) is sufficient to account for the work observed. On present
      information, which is imperfect in several respects, the chemical change is
      sufficient to account for the work. Estimates of the efficiency of transduction
      vary in different laboratories from 45 to 66%.

PMID- 1041246
TI  - Mechanical and biochemical cycles in muscle contraction.
AB  - The current biochemical approach to understanding the mechanism by which chemical
      energy is converted into mechanical energy in muscle is by investigating the
      kinetics of the reaction of ATP with the isolated contractile proteins in
      solution with stopped and quenched flow techniques. The results are interpreted
      in terms of a cycle of hydrolysis of ATP. The current mechanical approach lies
      through the kinetics of force production or length change in preparations with
      the contractile proteins intact, by following step changes in length or tension.
      The results are usually interpreted in terms of mechanical cycles of activity of
      cross-bridges, in which a cross-bridge progresses through a series of states with
      different mechanical properties. If the biochemist's and the mechanist's cycles
      are one and the same, a problem arises over the correspondence between states in
      the two cycles. One approach to answering this question is through the
      determination of the effect of pH and of such substances as ATP, ADP and
      inorganic orthophosphate on the mechanical response. We hope that these will act
      at known points in the biochemist's cycle and their influence upon the mechanical
      cycle should enable their location here to be ascertained. The paper deals with
      the effects of phosphate, ATP and magnesium ions on the mechanical response of
      insect flight muscle.

PMID- 1041247
TI  - Mitochondria, chloroplasts, and energy transfer: a discussion.

PMID- 1041248
TI  - [Nasopharyngeal meningococceal carrier rate during an epidemic in the armed
      forces].

PMID- 1041249
TI  - [Psychoses in epilepsy--classification and EEG-studies (author's transl)].
AB  - It is necessary to classify the epileptic psychoses before starting a comparative
      study between psychopathological and electroencephalographic findings. The
      knowledge of the epileptic psychoses is at the moment too incomplete for a
      systematic order following aetiological or topic aspects. The traditionally
      system of epileptic psychoses distributes in chronic and episodic, phasic,
      especially circular, reversible and irreversible psychopathological
      manifestations. We differentiate psychotic states with or without disturbances of
      consciousness. Well-known in EEG studies of symptomatic and endogenic psychoses
      is, that in these psychoses the same clinical syndrom can be related to normal
      and to pathological electroencephalographic findings. This contradiction could
      often be explained when the activity of the psychoses was taken into
      consideration. The activity of the psychoses is to be determined by the duration,
      number, intensity and variability of the psychopathological symptoms. From his
      own investigations from 30 patients with schizophreniform epileptic psychoses,
      episode affective disorders and both depressive and manic psychoses, it could be
      shown, that normal EEGs are markedly infrequent. Most often they occur in
      subacute schizophreniform epileptic psychoses. The EEG of active and particularly
      of schizophreniform epileptic psychoses is most often characterized by
      simultaneous appearance of sharp waves, paroxysmal dysrhythmias and abnormal
      rhythm formations. Active schizophreniform psychoses correlate usually with
      abnormal rhythms. These abnormal rhythms ("parenrhythmien") diminish parallel
      with loss of activity of the psychotic process, are correspondingly seldom seen
      in subacute psychoses, and are not demonstrable in inactive psychoses. The
      experience of an alternating correspondence between epileptic psychoses and
      frequency of seizures could be confirmed.

PMID- 1041250
TI  - [Methods for recording and quantitative measurement of rigidity and spasticity
      (author's transl)].
AB  - First pathophysiological aspects of rigidity and spasticity are described with
      special regard to the possibilities of errors during the measurement of muscle
      tone in man. The following methods are explained and discussed: Psychometric
      techniques, physical analysis of movements (kinesiology, photobadismography,
      kinetometry), pendulousness tests, investigations of reflexes (T-reflex, H
      reflex, H/M-ratio), electromyographic methods (after-activity, silent period,
      unloading-reflex, stretch-reflex, release-phaenomen), and torque measurements. In
      the main we discussed these techniques with the view-point of diagnosis and drug
      effects. Furthermore we expressed our opinion on the relevance of the different
      methods. Last the most important sources of errors are tabulated.

PMID- 1041251
TI  - [Occlusion of sinus sagittalis superior by infiltration of a tumor metastasis
      (author's transl)].
AB  - As a casuistic contribution to differential diagnosis of thrombosis of cerebral
      veins and sinuses a case of occlusion of sinus sagittalis superior by
      infiltration of an intracerebral metastasis from a teratoma of testis is
      reported. The leading symptoms - epileptic seizures, progressive hemiplegia,
      choked papilla and clouding of consciousness - gave rise to the tentative
      diagnosis of a cerebral tumor; in carotis angiography however, the metastasis was
      not detected, merely the occlusion of the sinus was demonstrated. Therefore the
      progress of the syndrome was misinterpreted as caused by an advancement of a
      venous thrombosis. Only autopsy showed the symptomless primary tumor and its
      formation of metastases.

PMID- 1041252
TI  - [Drug abuse in Norway (author's transl)].
AB  - The author gives a review of the problems of drug dependences in Norway. The rate
      of use of and dependency to drugs is discussed with special reference to
      adolescent drug habits, as registered yearly since 1968. About 18 percent of
      adolescents in Oslo have tried cannabis once or several times (1972, 1973).
      Although, the situation seems to have stabilized during the last two or three
      years. In other big towns in Norway the percentage is about half of that in
      Stockholm and Copenhagen. The attitude of young people to the use of drugs,
      including cannabis, is strongly negative. Tendencies in adolescent use of and
      dependency on drugs are described. In adults dependency on benzodiazepines seems
      to be the most common type of dependency. The methods used in treatment of drug
      dependents in Norway are described, as are also the prophylactic measures.

PMID- 1041253
TI  - [A conceptual model of the long-term configuration of manic-depressive illness
      (author's transl)].
AB  - A theoretical approach to manic-depressive illness is developed which explains
      the fundamental connection between psychopathologic symptoms and their
      arrangement in the course of time by means of one argument, i.e. the special
      variation of the diurnal organization of the drive and mood system. Elements of
      the model are a periodicity in a stringent sense, the hypothesis of the principal
      independence of the rhythmic organization of the drive system and the mood system
      which is postulated. In some special cases of different infradian rhythms there
      is a desynchronization of mood and drive which results both in a psychotic state
      and in rapid deformation of diurnal rhythms as well as slow interference cycles.
      This concept generates an interpretation of endogenity which uses only
      chronobiological terms; the hypothesis of somatogenesis is not implied but the
      physiologic systems involved are deemed to be intact, and the basic process is
      seen as a disturbance of the time structure of these functions. Thus, further
      investigation defines four fields: the depressive sleep disorder, the diurnal
      variation of mood, the chronobiology of the so-called mixed states and the time
      structure of the life-long sequence of phases and intervals. A new therapeutic
      concept works with artificial and fast sleep and wake periods and their
      transformation in order to achieve a resynchronization of the drive and mood
      system.

PMID- 1041254
TI  - Developing student-professor contracts in the clinical area.

PMID- 1041255
TI  - New tasks for psychiatric nurses.

PMID- 1041256
TI  - Trends in continuing education in the United States.
AB  - Developments in continuing education are closely related to professional and
      societal trends, developments in medicine and other health professions,
      scientific advancement, the state of the economy, and other factors.  It is safe
      to predict that in the future, increasing recognition will be given to continuing
      education as a necessity for professional practice.

PMID- 1041257
TI  - Continuing education strategies for a human service network. A case study in
      interdisciplinary education.

PMID- 1041258
TI  - Inservice educators provide continuing education.

PMID- 1041259
TI  - A computerized education and training record.

PMID- 1041260
TI  - Position statement on nursing licensure from the National League for Nursing.

PMID- 1041261
TI  - Synoptics: a simulation game for health professional students.

PMID- 1041262
TI  - Guest editorial: Reading and continuing education.

PMID- 1041263
TI  - A non-traditional course in intensive care nursing.

PMID- 1041264
TI  - A model of sex-role transcendence, role polarity and sex discrimination in
      education.

PMID- 1041265
TI  - Quality, accountability, and professional responsibility: new tasks for inservice
      education directors.

PMID- 1041266
TI  - Ambulation without legs.

PMID- 1041267
TI  - Nurses: prophets of doom?

PMID- 1041269
TI  - Editorial: Nursing or nursing home administration--a nurse's dilemma.

PMID- 1041268
TI  - Health care and the aged.

PMID- 1041270
TI  - Reminiscence group therapy project.

PMID- 1041271
TI  - Death with dignity.

PMID- 1041272
TI  - The therapeutic value of a dining room program in a geriatric setting.

PMID- 1041273
TI  - Are head nurses obsolete?

PMID- 1041274
TI  - Nurse & physician opinion of a modified work week trial.

PMID- 1041275
TI  - An uneasy look at performance appraisal.

PMID- 1041276
TI  - Leadership dynamics.

PMID- 1041277
TI  - Accountability in mental health care.

PMID- 1041278
TI  - A philosophy of teaching applied to administration.

PMID- 1041279
TI  - Letter: Management effectiveness and the role making process.

PMID- 1041280
TI  - Letter: chloramphenicol- and ampicillin-resistant typhoid fever.

PMID- 1041281
TI  - [Multiple drug resistance of Enterobacter-Serratia group isolated from clinical
      materials (author's transl)].
AB  - We determined the drug susceptibility of Serratia-Enterobacter group isolated
      from clinical materials between October 1973 and May 1974 by disk method and agar
      plate dilution method, and compared the drug susceptibility and multiple
      resistance among pigment-producing Serratia, pigment non-producing Serratia and
      Enterobacter. We used following drugs for susceptibility tests; ampicillin,
      carbenicillin, sulbenicillin, cephaloridine, streptomycin, kanamycin, dibekacin,
      gentamicin, chloramphenicol, tetracycline, colistin, nalidixic acid,
      nitrofurantoin and erythromycin. Above one half of strains of Serratia and
      Enterobacter was isolated from sputa and pharyngeal swabs. Almost all strains of
      Serratia and Enterobacter wer resistant to ampicillin, cephaloridine and
      erythromycin, but sensitive to gentamicin and dibekacin. Resistant strains were
      more found in Serratia than in Enterobacter. Pigment non-producing strains of
      Serratia were more sesistant to chemotherapeutics than pigment producing strains.
      There were many multiple resistant strains in Serratia and Enterobacter,
      especially in pigment non-producing strains of Serratia, and the strains isolated
      from urine were resistant to more drugs compared with the strains from other
      materials.

PMID- 1041283
TI  - [Current status and overview of the high school nursing course and the 2-year
      post high-school nursing course].

PMID- 1041282
TI  - [Clinical experiences of lividomycin on respiratory tract infections (author's
      transl)].
AB  - Clinical effects of a newly developed aminoglycoside antibiotic lividomycin, were
      investigated in 13 patients suffering from respiratory infections. 1. A total of
      13 patients with the following infectious diseases was treated with 1 g/day of
      lividomycin for 3 to 11 days (average 6.7 days): Acute pneumonia 3 cases,
      bronchiectasis 3 cases, acute bronchitis 5 cases, suppurative diseases of the
      lung 1 case, and pyothorax 1 case. As the results, the antibiotic was effective
      in 5 patients, moderately effective in 4 patients and ineffective in 4 patients,
      and thus the global effective rate was 62.9% (9/13). 2. As in the case of
      kanamycin, lividomycin indicated fairly good sensitivity against a total of 17
      strains comprising Staphylococcus aureus (7 strains), alpha-Streptococcus (2
      strains), beta-Streptococcus (3 strains), gamma-Streptococcus (1 strain),
      Neisseria (2 strains) and Haemophilus (2 strains) which were isolated from
      sputum. 3. No side effects attributable to lividomycin were observed.

PMID- 1041284
TI  - [Criteria of evaluation of clinical training. A rating list and its keys].

PMID- 1041285
TI  - [Attitudes and behavioral trends of nursing students (near graduation) and nurses
      concerning assistance of patients in the act of excretion].

PMID- 1041286
TI  - [Sex discrimination in health care].

PMID- 1041287
TI  - [Nursing study as an academic entity. V. Nursing as a scientific discipline].

PMID- 1041288
TI  - [Concept and teaching of social training].

PMID- 1041289
TI  - [Trial in clinical nursing training. V. Comprehensive training of clinical
      nursing - a general outline].

PMID- 1041290
TI  - [New clinical training plan for the purpose of developing an active interest in
      students--toward establishment of nursing as a professional entity].

PMID- 1041292
TI  - [Relationship between the nurse and medical care in the hinterland. An interview
      with Ms. Kobayashi, President of Japan Nursing Association].

PMID- 1041291
TI  - [Discussion: on the case erroneously diagnosed as encephalomalacia and left
      untreated for 4 months. (3)].

PMID- 1041293
TI  - [Report by a public health nurse in a village without a doctor].

PMID- 1041294
TI  - [Experience of a public health nurse in an isolated village].

PMID- 1041295
TI  - [Experience of a public health nurse in an isolated village].

PMID- 1041297
TI  - [Activities and problems of a public health nurse in a small village].

PMID- 1041296
TI  - [Personal satisfaction of a public health nurse working in a small village].

PMID- 1041298
TI  - [Health problems in a small village observed by a public health nurse].

PMID- 1041299
TI  - [Theories concerning health. (4)].

PMID- 1041300
TI  - [Public health nursing policies concerning care of the aged population at Kangawa
      cho (Kanagawa Pref.) - a health survey on the aged population of the area].

PMID- 1041301
TI  - [Home visit of an aged bedridden patient living with an uncooperative family].

PMID- 1041302
TI  - [Survey on the sexual attitude of youths (1)].

PMID- 1041304
TI  - [Nursing seminar. I. Public and personal hygiene: implementation of public health
      legislation].

PMID- 1041303
TI  - [Discussion: The role of nursing in medical services - expectation of nursing
      services].

PMID- 1041305
TI  - [Nursing seminar: II. Public and personal hygiene: The daily life and the
      environmental conditions].

PMID- 1041306
TI  - [Nursing seminar. III. Public and personal hygiene: prevention of diseases--from
      early diagnosis and treatment to preventive medicine].

PMID- 1041307
TI  - [Inner struggle of the patient, an experience of a nurse. (1)].

PMID- 1041308
TI  - [Degree awarding course for the practical nurse - importance of the goal in the
      nursing study and pride in being a capable nurse].

PMID- 1041309
TI  - [Students' nursing report. Nursing of a patient with pharyngeal tumor following
      tracheotomy].

PMID- 1041310
TI  - Child health conference--nurses' resource manual. Visiting Nurse Association of
      New Haven, New Haven, Connecticut.

PMID- 1041311
TI  - Dosage calculation: method and workbook.

PMID- 1041312
TI  - [Urinary uropepsin activity in patients with closed cranial trauma].
AB  - The authors determined uropepsin activity in 24-hour urine in 30 cases of mild
      craniocerebral trauma. The determinations were done on the 1st, 3d and 7th days
      after trauma. The control group consisted of 15 healthy subjects. The activity of
      the enzyme was raised only on the 1st day after trauma and it may be explained as
      a result of stress.

PMID- 1041313
TI  - Mr. Peters was afraid to face me ... and his problem.

PMID- 1041314
TI  - Dealing with... rage. Nursing grand rounds.

PMID- 1041315
TI  - What are your feelings about death and dying? Part 3.

PMID- 1041316
TI  - Wound suction. Better drainage with fewer problems.

PMID- 1041318
TI  - Whadda ya say at report?

PMID- 1041317
TI  - What you should know about communicable diseases and their immunizations. Part
      II. Diphtheria, pertussis, tetanus, and polio.

PMID- 1041319
TI  - Emergency care for facial injuries.

PMID- 1041320
TI  - Administering potassium chloride.

PMID- 1041321
TI  - We were no match for "Zorba the Greek".

PMID- 1041322
TI  - All about gastrointestinal intubation.

PMID- 1041323
TI  - Considerate care of the elderly. Little things mean a lot.

PMID- 1041324
TI  - Examining the chest. Part II. The heart.

PMID- 1041325
TI  - Round-the-clock visitor.

PMID- 1041326
TI  - The G.I. bleeder - seldom as safe as he seems. Nursing grand rounds.

PMID- 1041327
TI  - What are your feelings about death and dying? Part 2.

PMID- 1041328
TI  - Trivia, illusions, and quirks - what they can tell you about your patients.

PMID- 1041329
TI  - Overcoming the learning disabilities of stroke.

PMID- 1041331
TI  - Shifting smoothly.

PMID- 1041330
TI  - What you should know about communicable diseases and their immunizations. Part I.
      The three Rs.

PMID- 1041332
TI  - Should you become a school nurse practitioner?

PMID- 1041333
TI  - Is there a place for a rocking chair in your newborn nursery? A review of studies
      on the effect of rocking the newborn.

PMID- 1041334
TI  - Bathing the ICN baby.

PMID- 1041335
TI  - IAM (Immunization Action Month); major role for the PNP/A.

PMID- 1041336
TI  - Family assessment and intervention plan.

PMID- 1041337
TI  - Hypertension in adolescents.

PMID- 1041338
TI  - A child grows. Part 4. The child's perceptual and linguistic development.

PMID- 1041340
TI  - Personification: patient and nurse problem.

PMID- 1041339
TI  - Commentary on "getting into print".

PMID- 1041341
TI  - Communicating with depressed persons.

PMID- 1041342
TI  - "Bargaining" to improve communications in conjoint family therapy.

PMID- 1041343
TI  - Rabbit--therapeutic prescription.

PMID- 1041344
TI  - Gender identity crises in young schizophrenic women.

PMID- 1041345
TI  - The relationship of significance of nurse-patient relations to pain reaction in
      labour.

PMID- 1041347
TI  - Bedpan anxiety.

PMID- 1041346
TI  - Patient orientation.

PMID- 1041348
TI  - A study of work performance.

PMID- 1041349
TI  - Facts and fancies in human labour.

PMID- 1041350
TI  - Cardiac arrest and resuscitation.

PMID- 1041351
TI  - Medical hypnosis.

PMID- 1041352
TI  - Ultrasonics in obstetrics.

PMID- 1041353
TI  - Nursing management of patients with traumatic cord bladder.

PMID- 1041354
TI  - Personnel management and the nursing service.

PMID- 1041355
TI  - Breast feeding in the lower socio-economic group.

PMID- 1041356
TI  - New lease of life for heparin.

PMID- 1041357
TI  - Substitutes for doctors.

PMID- 1041358
TI  - Cardiac catheterisation.

PMID- 1041359
TI  - Cardiac valve replacement.

PMID- 1041360
TI  - Care of the cardiothoracic patient. Physiotherapy.

PMID- 1041361
TI  - In sickness and in wealth. Going private.

PMID- 1041363
TI  - Editorial: Prisoners of the body.

PMID- 1041362
TI  - Dynamic aspects in clinical learning. 3.

PMID- 1041364
TI  - What is a nurse?

PMID- 1041366
TI  - Restricted growth.

PMID- 1041365
TI  - Controversy corner 1974--reorganisation or demoralisation?

PMID- 1041367
TI  - A hospital with Sphynx for company.

PMID- 1041368
TI  - In sickness and in wealth. The 'customers'.

PMID- 1041370
TI  - Editorial: The Cinderella service.

PMID- 1041369
TI  - Cancer education and training.

PMID- 1041371
TI  - Health Authority membership.

PMID- 1041372
TI  - Accidental hypothermia in fit young adults.

PMID- 1041373
TI  - Venomous fish.

PMID- 1041374
TI  - Nursing care study: multiple fractures caused by a road accident.

PMID- 1041376
TI  - Diseases in the Bible.

PMID- 1041375
TI  - Induction of labour.

PMID- 1041377
TI  - Safely delivered.

PMID- 1041378
TI  - Supporting the elderly.

PMID- 1041379
TI  - Camels or thoroughbreds?

PMID- 1041380
TI  - The natural transition.

PMID- 1041381
TI  - ICN takes some forward-looking decisions.

PMID- 1041382
TI  - First-class beds.

PMID- 1041384
TI  - Question and answer: some helpful hints at examination time.

PMID- 1041383
TI  - VD-the new danger.

PMID- 1041385
TI  - Nursing care study. Traumatic amputation of the right arm.

PMID- 1041386
TI  - Schizophrenia.

PMID- 1041387
TI  - What is rickets?

PMID- 1041388
TI  - Resettlement; helping the disabled back to work.

PMID- 1041389
TI  - Drug administration.

PMID- 1041390
TI  - Learning to understand.

PMID- 1041391
TI  - Screening for inborn errors of metabolism in infancy.

PMID- 1041392
TI  - Registered nurse training in developing countries.

PMID- 1041394
TI  - [Surgery for thyroid diseases].

PMID- 1041393
TI  - In vivo development of resistance to clindamycin by Staphylococcus aureus.

PMID- 1041395
TI  - [On blood donors].

PMID- 1041396
TI  - [Limits of nursing activities].

PMID- 1041397
TI  - [The appropriateness of the nursing profession].

PMID- 1041398
TI  - [Sister Maria and others].

PMID- 1041399
TI  - [Nursing in thyroid diseases].

PMID- 1041400
TI  - [Diet in hyperthyroidism].

PMID- 1041401
TI  - [Neoplasms of the digestive system].

PMID- 1041402
TI  - [Why do they retire from the profession?].

PMID- 1041403
TI  - The effect of potassium chloride infusion of parotid salivary flow and
      composition in conscious sheep.
AB  - The composition and flow of parotid saliva in conscious sheep was measured
      before, during and after the intravenous infusion of 0-43 M-KCl or 0-43 M-NaCl at
      2 ml./min for 2 hr. The salivary flow rate was depressed during the infusion of
      potassium chloride into both intact sheep and adrenalectomized sheep. As the
      salivary flow was unchanged by sodium chloride infusion it was concluded that the
      potassium ion was responsible for the decrease in flow and that this effect was
      not mediated through any of the adrenal hormones. The highly significant negative
      correlation between plasma potassium concentration and salivary flow throughout
      all potassium infusions indicated that the extent to which the salivary flow was
      depressed varied with the degree of hyperkalaemia. Except for situations where
      mineralocorticoid levels were likely to be elevated the concentrations of sodium
      and potassium in the saliva were positively correlated with the plasma
      concentrations of these ions. The salivary bicarbonate concentration of the
      saliva was negatively related to flow. The chloride concentration of the saliva
      was negatively correlated with salivary flow during all potassium chloride
      infusions.

PMID- 1041404
TI  - Flow in glass models of arterial bifurcations and berry aneurysms at low Reynolds
      numbers.
AB  - Using the dye injection technique, flow at low Reynolds numbers was studied in
      glass models which simulated arterial bifurcations of varying angles and had
      varying bluntness of the apex or crotch. Forks bearing small saccular
      evaginations simulating berry aneurysms were investigated similarly.. At quite
      low Reynolds numbers in all the models small wave motion was observed at the
      forks. At higher Reynolds numbers and below the critical values for turbulence,
      larger Vortices akin to a Karman vortex street were shed from most of the forks.
      The disturbances were attributed to boundary layer separation and a jet-edge
      effect.

PMID- 1041405
TI  - Changes in renal haemodynamics and electrolyte excretion during acute
      hyperkalemia in conscious adrenalectomized sheep.
AB  - The p-aminohippurate (PAH) clearance, inulin clearance and the excretion of
      electrolytes by 10 adrenalectomized sheep were measured before, during and after
      the infusion of 0-43 M-KCl at 2 ml./min for 2 hr. The PAH clearance increased as
      the plasma potassium concentration increased up to approximately 6-0 m-mole/l.
      Further increases in plasma potassium were associated with a progressive return
      of the PAH clearance to or below the pre-infusion levels. At its maximum the PAH
      clearance was 1-228 +/- 0-032 (S.E. of mean) times the pre-infusion levels. The
      inulin clearance increased to reach a mazimum coincident with or subsequent to
      the maximum PAH clearance. The maximum level of inulin clearance during the
      hyperkalaemia was 1-158 +/- 0-020 times the pre-infusion clearance. The
      increments in the clearance of potassium and of bicarbonate rose rapidly to
      exceed the increment in inulin clearance during the hyperkalaemia in all
      experiments. The increments in the clearance of sodium and of chloride exceeded
      the increment in inulin clearance in more than half the experiments. It was
      concluded that although hyperkalaemia was associated with increased glomerular
      filtration much of the increased excretion of sodium, chloride and bicarbonate
      was derived from depressed tubular reabsorption of the ions. When the infusion
      experiments were repeated on the same animals the sheep demonstrated an improved
      ability to control the rise in plasma potassium concentration which was similar
      to potassium adaptation described in other species. There were no apparent
      differences between sheep maintained on 1-5 mg and 5 mg deoxycorticosterone
      acetate daily in their adaptation to potassium loading and the effect was
      tentatively attributed to the level of steroid maintenance being chronically
      high. The toxicity of hyperkalaemia was not lessened by this adaptation to
      potassium loading.

PMID- 1041406
TI  - Plasma iron transport during egg laying and after oestrogen administration in the
      domestic fowl (Gallus domesticus).
AB  - The concentrations of 59Fe and of radioiodinated transferrin and albumin were
      measured in the blood, liver, spleen, bone marrow and ova at different times
      after the injection of transferrin-bound 59Fe and the labelled proteins into non
      laying, laying and oestrogen treated chickens. In the egg-laying and oestrogen
      treated birds the 59Fe of the plasma was rapidly transferred from transferrin to
      another component with the properties of th phosphoprotein, phosvitin.
      Radioactive iron, and labelled transferrin and albumin to a lesser extent,
      entered the ova only while they were in the ovary. Relatively more labelled
      transferrin than albumin was found in all the tissues studied except in the ova,
      in which the two labelled proteins were present in the same relative
      concentration as in the plasma. It is concluded that, during egg laying and after
      oestrogen treatment, plasma iron bound to transferrin is taken up by the liver,
      incorporated into phosvitin and is then secreted into the plasma leading to
      elevation of the plasma iron concentration and transfer of iron to the ova.

PMID- 1041407
TI  - Emergency management of acutely burned patients.

PMID- 1041408
TI  - Surgery + intensive nursing care equal this happy ending.

PMID- 1041409
TI  - Keeping tabs on I.V. fluid intake.

PMID- 1041410
TI  - Emergency care of the hemophiliac.

PMID- 1041411
TI  - For earlier correction of great-artery transposition.

PMID- 1041412
TI  - As flu season approaches: a call to battle.

PMID- 1041413
TI  - Modern treatment for an old complaint, headache.

PMID- 1041414
TI  - Nursing decisions: experiences in clinical problem solving. A postsurgical
      patient with leg pain.

PMID- 1041415
TI  - "We didn't know better, so we did it wrong".

PMID- 1041417
TI  - "We took the strain out of nursing and lab relations".

PMID- 1041416
TI  - A diabetic child is still a child--with diabetes.

PMID- 1041418
TI  - Nursing management in sickle cell disease.

PMID- 1041419
TI  - A special kind of kidney patient.

PMID- 1041420
TI  - Nurse-epidemiologist: key to infection control.

PMID- 1041421
TI  - How nurses view patient suffering.

PMID- 1041422
TI  - Fighting the second most frequent infections. Part 1.

PMID- 1041423
TI  - At last: early warning against neurologic disaster.

PMID- 1041424
TI  - New light on fatal complications of MI.

PMID- 1041426
TI  - What to do for a monitored patient.

PMID- 1041425
TI  - Long-term survival after myocardial infarction.

PMID- 1041427
TI  - Fiberoptic endoscopy of the UGI.

PMID- 1041428
TI  - Fiberoptic endoscopy of the UGI and of the colon.

PMID- 1041429
TI  - Trauma training: expanding the role of ED nurses.

PMID- 1041430
TI  - If you ever need to return to nursing, here's how.

PMID- 1041431
TI  - The renal humoral system: a cause of hypertension?

PMID- 1041433
TI  - When a child dies, accident or suicide?

PMID- 1041432
TI  - What you need to know about bioavailability.

PMID- 1041434
TI  - Suicide: some children really mean it.

PMID- 1041435
TI  - For nursing adventure, team up with MEDICO!

PMID- 1041436
TI  - Surgery: successful treatment for deep decubiti.

PMID- 1041438
TI  - The good and bad of 12-hour shifts.

PMID- 1041437
TI  - Gastric acid down, OB patient safety up!

PMID- 1041439
TI  - Nursing decisions: experiences in clinical problem solving. Ms. F.; a restless
      post-thyroidectomy patient.

PMID- 1041440
TI  - The adolescent unit: tailored for teen-age patients.

PMID- 1041441
TI  - Stroke! Nursing insights from a stroke-nurse victim.

PMID- 1041442
TI  - Guidelines to stroke-patient care.

PMID- 1041444
TI  - Pay yourself a pension-and enjoy a tax break now!

PMID- 1041443
TI  - This delivery draping dazzled the doctor.

PMID- 1041445
TI  - In defense of the private duty nurse.

PMID- 1041446
TI  - The many faces of alcoholism.

PMID- 1041447
TI  - Pace: planned acquisition of clinical experience.

PMID- 1041449
TI  - The art and science of supervision. Prescription for frustration.

PMID- 1041448
TI  - How does the unit manager system affect the head nurse?

PMID- 1041450
TI  - Supervisor overseas: Agency nurse reductions.

PMID- 1041451
TI  - Law for the nurse supervisor. The Buckley privacy law.

PMID- 1041452
TI  - Statement of Illinois Nurses' Association on the effect of the 1974 Taft-Hartley
      Act amendments on hospital relationships with nurses' associations.

PMID- 1041453
TI  - A subchronic study of the toxicity of an orally administered benzoquinolizinyl
      derivative in the rat and dog.
AB  - The subchronic toxicity of the trans isomer of N-(1,3,4,6,7-hexahydro-11bH
      benzo[a] quinolizin-2-yl) propionanilide hydrochloride (TR2379), a new
      antihypertensive agent, was studied in rats and dogs. TR2379 was well tolerated
      for 13 weeks at daily p.o. doses up to 200 mg/kg in the rat and 70 mg/kg in the
      dog. However, severe toxic manifestations, including death, were elicited in the
      rat at 820 mg/kg and in the dog at 160 mg/kg. Toxicity in both species was
      characterized by a reduction in body weight gain and an increase in the weight of
      several organs, (liver, heart, kidneys, adrenals, and thyroids). Serum alkaline
      phosphatase, which was not assayed in the rat, was markedly increased in the dog.
      Microscopic examination of the various tissues revealed no evidence of organ
      pathology in either species.

PMID- 1041454
TI  - Influence of a benzoquinolizinyl derivative on serum and hepatic alkaline
      phosphatase activity in the dog and rat.
AB  - Oral administration of 100 mg/kg of TR2379, N-(1,3,4,6,7-hexahydro-11bH
      benzo[a]quinolizin-2-yl) propionanilide hydrochloride, for 20--29 days to 6 dogs
      resulted in significant elevations of alkaline phosphatase (AP) activity in serum
      and in liver microsomes. Results of biochemical and histochemical experiments
      revealed that the liver was the sole source of the increased AP activity but
      there was no evidence of liver damage. The subchronic (7-35 day) p.o.
      administration of TR2379 at 820 mg/kg to 20 rats did not produce elevation of AP
      activity in serum or liver. Relative liver weights (g/100 g body wt) of rats
      receiving TR2379 were significantly increased during the 2nd week and thereafter.
      The results of these studies suggest that high doses of TR2379 induce protein
      synthesis in dog and rat liver and induce AP activity in the dog but not in the
      rat. The elevation of AP in the dog is not considered to have toxicologic
      implications.

PMID- 1041455
TI  - Certified nurses face many responsibilities.

PMID- 1041456
TI  - ANA certification program has 15-year history.

PMID- 1041458
TI  - Editorial: Nurses must press for consumer's right to health care.

PMID- 1041457
TI  - Sen. Kennedy Aide speaks to health legislation.

PMID- 1041459
TI  - Rights outlined for directors of nursing.

PMID- 1041460
TI  - Transcultural nursing presents exciting challenge.

PMID- 1041462
TI  - ANA labor relations workshops win encore.

PMID- 1041461
TI  - Indian nurse considers cultural traits.

PMID- 1041463
TI  - NLRB rules on nursing's community of interest.

PMID- 1041464
TI  - Facilitatprs discuss challenges of NHI.

PMID- 1041465
TI  - Alternatives to institutionalization offered elderly.

PMID- 1041466
TI  - Editorial: Bylaws need periodic revision.

PMID- 1041467
TI  - Involvement is a must for the well-rounded graduate.

PMID- 1041468
TI  - Indian nurses hold national conference.

PMID- 1041470
TI  - Mandate for circulator shows RN role.

PMID- 1041469
TI  - Women working harder, enjoying less leisure.

PMID- 1041471
TI  - Current works to define, classify nursing diagnoses.

PMID- 1041472
TI  - Congress theme should be put into practice.

PMID- 1041473
TI  - AORN survey: OR staffing, pay policies.

PMID- 1041474
TI  - Chemosurgery in skin cancer.

PMID- 1041475
TI  - Localizer cast, fusion for scoliosis.

PMID- 1041476
TI  - OR care for epistaxis patients.

PMID- 1041477
TI  - Findings of study on surgical services.

PMID- 1041478
TI  - OR nursing content in curriculum design.

PMID- 1041479
TI  - Student reaction to OR experience.

PMID- 1041480
TI  - Cooperative approach to nursing education.

PMID- 1041481
TI  - A graphic look at OR utilization.

PMID- 1041483
TI  - Looking back at Papua New Guinea.

PMID- 1041482
TI  - Bilateral deep brachial vein thrombophlebitis due to vibrio fetus.
AB  - A patient had bilateral deep brachial vein thrombophlebitis in which Vibrio fetus
      was recovered from six blood cultures of the six drawn. Fever and phlebitis
      continued with treatment with intravenous doses of heparin and oxacillin but
      rapidly improved with treatment change of oxacillin to clindamycin. In vitro
      antibiotic disk susceptibility testing confirmed resistance to oxacillin and
      susceptibility to clindamycin. Vibrio fetus infection is associated with the
      vascular endothelium in this and previously reported cases

PMID- 1041484
TI  - Life times: the last of William Henry.

PMID- 1041485
TI  - Immunization.

PMID- 1041486
TI  - Improving nursing practice and patient care through education.

PMID- 1041487
TI  - The development of a new hospital bed.

PMID- 1041488
TI  - Team nursing: an essential ingredient for success.

PMID- 1041489
TI  - Editorial: Something attempted.

PMID- 1041490
TI  - A computer study of bacterial resistance patterns to antibiotics.
AB  - The study of resistance patterns of strains of bacteria to antibiotics in
      different regions of a country and, if possible, comparing them at international
      level appears to be a useful exercise. The patterns of resistance during 1968-71
      revealed an increasing resistance for most antibiotics with an unexpected
      increase for chloramphenicol. Notable is a decreasing resistance, not only of
      coagulase-positive strains of Staphylococcus aureus but also of other micro
      organisms towards doxycycline. For practical purposes there was no difference
      between the sensitivy of the isolates from hospitalized patients and from out
      patients, though less pronounced in the latter. The incidence of resistance among
      strains isolated from the paediatric ward was low. Comparatively small changes in
      molecular structure may result in relatively large differences in the sensitivity
      pattern; for example, between tetracycline and doxycycline (Vibramycin, Pfizer),
      the greatest activity is seen with doxycycline.

PMID- 1041491
TI  - [Amoxicillin: microbiological, pharmacokinetic and therapeutic aspects].

PMID- 1041492
TI  - [The EEG during post-traumatic coma (author's transl)].
AB  - With traumatic coma, the underlying pathomorphology may vary and it may not
      always be possible to establish it. Possible organic lesions are contusions of
      brain, oedema, intracranial haematoma, fat embolism, or an open brain injury. On
      the other hand there may be no organic lesions, as for instance in concussion. In
      every case, the leading clinical symptom is alteration of consciousness. This
      arises through interference, at some point, with the reticulo-thalamocortical
      system which is responsible for the regulation of consciousness. Concurrently
      with the alteration of consciousness, the EEG also shows changes. At the same
      time, the EEG is affected by the other effects of trauma upon the brain. Becuase
      of this, this EEG is not exclusively determined by the degree of unconsciousness.
      The possible causes of traumatic unconsciousness, and of the pathological waves
      seen in such cases, cannot always be established in clinical medicine, and
      experimental studies particularly with regard to neurophysiology are required to
      explain them....

PMID- 1041493
TI  - [The clinical picture and psychopathology of the XYY constitution].
AB  - It is reported on 2 cases of the XYY chormosomal constitution. The patients were
      comparable only with respect to some somatic deviations. Age at manifestation of
      psychic abnormalities as well as the degree of deviation of behaviour were rather
      different. One patient got his psychic traumatization mainly in early childhood
      where as the other suffered from a more puberal conflict. Genetic disposition may
      be the basic cause of the psychological abnormalities. Yet, the degree of
      deviation seems to be influenced mainly by environmental factors.

PMID- 1041494
TI  - ["Fatiguability" in myasthenic syndromes].
AB  - Neuromuscular disorders accompanied by a "myasthenic reaction", but without other
      symptoms of myasthenia gravis and no therapeutic response to cholinergic drugs
      may be called myasthenic syndromes. The abnormal fatigability can be shown in the
      electromyogram. Lasting voluntary contraction of a muscle shows a rarefication of
      the EMG-pattern. Sometimes during repetitive stimulation of the motor nerve a
      decrease in the amplitude of the muscle potential may occur. This decrease is
      poorly influenced by cholinergic drugs. Often this observation was present in
      patients with myositis and myotonic dystrophy, sometimes in other myopathies and
      seldom in neurogenic disorders. A failure in the neuromuscular transmission is
      discussed not only in myasthenia gravis, but also in myasthenic syndromes. But
      there may be another explanation. A decreased number of intact muscle fibers
      during lasting innervation will cause a more rapid fatigation of the muscle
      fibers and in this way there will be an exhaustion. It is discussed, whether the
      symptoms in myasthenic syndromes can be explained by an abnormal "fatigability".

PMID- 1041495
TI  - [Neurological aspects of nerve transplantation].
AB  - Neurological aspects of nerve-grafting are discussed. Methods designed for
      quantification of the pre-and the postoperative neurologicalsyhdromes ("index of
      integral function") and for the selective description of sensory impairment
      ("index of sensibility") are presented. These methods may facilitate the
      comparison of results of different investigators. The rate of positive results
      could possibly be raised if patients could be operated earlier. Considerable
      improvement can be expected only, when nervegrafting takes place as soon as
      possible, at the latest six months after injury. Grafting is no longer
      recommendable, when 12 months or more have passed even when only sensory recovery
      is aimed at. The reason is that reduction of sensory functions usually causes
      less impairment than vegetative and trophic changes which may occur as sequelae
      of the operation.

PMID- 1041496
TI  - Nursing in Lebanon.

PMID- 1041498
TI  - Roles that nurses in the community can play in nursing research.

PMID- 1041497
TI  - Simulation techniques for nursing education.

PMID- 1041499
TI  - Student nurse problems: the case of Mary Ellen Waters.

PMID- 1041500
TI  - Resistance categories of enterobacteria to beta-lactam antibiotics.
AB  - The activities of cephaloridine, cephalothin, and ampicillin against dense
      cultures of 103 ampicillin-resistant gram-negative bacilli were compared in a
      turbidimetric system. The organisms were divided into two groups according to
      their behavior in conventional minimal inhibitory concentration titrations: those
      fully resistant to ampicillin at a concentration of 500 mug/ml and those
      inhibited by 32-500 mug of ampicillin/ml. Of the 83 strains in the first group,
      most were more sensitive to cephalothin than to cephaloridine, whereas the 20
      strains in the second group exhibited a number of interesting properties peculiar
      to them. On the basis of these and previous results, six distinct categories of
      resistance to beta-lactam antibiotics have been detected among enterobacteria.

PMID- 1041501
TI  - Do boys with a low-average I.Q. actually have a low self-esteem?
AB  - The purpose of this study was to gain an understanding of the needs, fears,
      aspirations, and attitudes of the low-average elementary and junior high age boy.
      The settings were two schools, a junior high (grades 9-12) and an elementary
      school (grades 5-6), located in a working class community. Two separate groups
      involving boys ages 11 and 12 years, and boys ages 14 and 15 years, met for five
      consecutive meetings. The structured interview in a group setting was chosen to
      increase the likelihood of a spontaneous, open interchange, as opposed to a more
      restricted response pattern. All subjects had failed at least one year, had
      maintained a stable I.Q. of 80-90 during their school years and were level in one
      or more subjects. The findings suggest caution in automatically equating low
      average intelligence in boys with low self-concept, lack of career plans, family
      problems, and other similar stereotypes.

PMID- 1041502
TI  - A perspective on drinking among teenagers with special reference to New York
      State studies.

PMID- 1041503
TI  - Assessment of the cognitive effect of a prototype health education unit on sixth
      grade students.
AB  - The purpose of this study was to assess the cognitive effects of a prototype
      health education teaching model on the cardiovascular health knowledge of
      selected sixth grade students. The level of significance for the study was set at
      .05. No significant differences between pre-test mean scores, experimental to
      control group were found. Significant differences between post-test mean scores,
      experimental to control group were noted. No significant differences between
      control group pre-test to post-test mean scores were found. Although significant
      experimental group pre-test to post-test mean scores were found in all four
      locations, no significant differences were found between the experimental post
      test mean scores by geographic location.

PMID- 1041504
TI  - A study of personality change associated with the conducting of a high school
      unit on homosexuality.

PMID- 1041505
TI  - The effect of individual contracting and guided group interaction upon behavior
      disordered youth's self-concept.

PMID- 1041506
TI  - Smoking and obesity: the behavioral ramifications.

PMID- 1041507
TI  - Position paper: philosophy and goals for school nurse educational preparation.

PMID- 1041508
TI  - Values clarification and the school nurse.

PMID- 1041509
TI  - Kindergarten screening program for learning disabilities.

PMID- 1041510
TI  - The sick role and the role of the physician reconsidered.
AB  - The main substance of this paper was presented orally at a meeting of the Sick
      Role, organized and chaired by Andrew Twaddle. It was a commentary on four papers
      and the oral discussion of them. In response to these the paper first discusses
      the relation of the sick role to deviant behavior and the motivation to become
      and remain ill. The position was taken that the author never had meant to confine
      the category of illness to deviant behavior, though its negative valuation should
      not be forgotten. Nor had he confined it to cases of acute illness, omitting
      consideration of chronic and other types. The most important issue, however,
      concerned the structure of the relation between physician and patient. Though
      insisting that interaction between them is two-way, not one-way, the author
      insisted that the relation is basically asymmetrical because of the physician's
      expertise in health matters, gained through training and experience, and his
      special fiduciary responsibility for the care of the sick. In this respect the
      relationship is different from others such as the competitive market or the
      democratic association, but is comparable to the relation of teacher and student
      in higher education.

PMID- 1041511
TI  - The longevity and mortality of American physicians, 1969-1973.
AB  - This paper analyzes the mortality experience of male and female physicians during
      the five-year period 1969 through 1973 in terms of age, sex, geographic location,
      and medical specialty. Physician mortality and longevity are then compared with
      the experience prevailing among the U.S. white population of the same age and
      sex. Relationships between socioeconomic status and mortality suggest that
      physicians should have a better mortality experience than the general population
      and as such have a greater overall expectation of life. Previous studies of
      physician mortality in the United States using data from the records of the
      American Medical Association, have examined physician mortality relative to
      comparable groups of white males. No studies of physician mortality utilizing a
      population-based approach have been reported since that of the 1949 to 1951
      population of physicians, and previous studies may have been subject to certain
      limitations in the data. Empirical findings are presented which demonstrate the
      improvement in physician longevity since 1925. The relationship between age- and
      sex-specific mortality and geographic location and medical specialization is also
      discussed.

PMID- 1041512
TI  - The effect of amniotic fluid removal on pulmonary maturation in sheep.

PMID- 1041513
TI  - [Ampicillin in pediatric practice].

PMID- 1041514
TI  - Antimicrobial therapy of anaerobic infections.

PMID- 1041515
TI  - Renal excretion of monovalent cations during functional adrenalectomy in
      conscious sheep.
AB  - In sheep with both adrenals removed and one re-implanted in the neck, functional
      adrenalectomy was produced in conscious undisturbed animals by occluding the
      blood supply to the transplanted gland. Functional adrenalectomy caused a fall in
      potassium excretion and a very large increase in sodium excretion and was
      reversed by aldosterone. Hydrocortisone infusions slightly increased potassium
      excretion and reduced solute-free water reabsorption. Preliminary evidence
      suggests that potassium secretion into urine was still occurring during the 8 hr
      period of adrenal occlusion and functional adrenalectomy.

PMID- 1041516
TI  - Antibiotics in the treatment of chronic staphylococcal osteomyelitis.
AB  - Fourteen patients with chronic osteomyelitis were treated with oral penicillin,
      oxacillin, or cloxacillin at a dose of 5 gm/day, plus 0.5 gm of probenecid
      (Benemid) three or four times per day. Treatment was continued for 2 1/2 to six
      months. In ten patients, evidence of osteomyelitis disappeared and there has been
      no recurrence during follow-up periods varying from six months to 2 1/2 years.
      Significant hepatotoxicity was encountered in two patients; one similar patient,
      not in this series but receiving a similar regimen of antibiotic, developed
      leukipenia. Thus, patients with chronic osteomyelitis appear to benefit from such
      a therapeutic program, but they must be monitored closely for hepatic or
      hematologic toxicity.

PMID- 1041518
TI  - Proper use of corticosteroids.

PMID- 1041517
TI  - The great mass murder trial.

PMID- 1041519
TI  - Air shipment of pets: what to tell your clients.

PMID- 1041520
TI  - Avulsion of the medical head of the gastrocnemius in the dog.

PMID- 1041521
TI  - Streptococcus canis: an isolate from a canine uterus.

PMID- 1041522
TI  - Critical tests with pyrantel pamoate against internal parasites in dogs from
      Wisconsin.

PMID- 1041523
TI  - Occipital dysplasia and hydrocephalus in a Toy Poodle.

PMID- 1041524
TI  - Intratracheal gentamicin and dexamethasone for treatment of infectious
      tracheobronchitis in the dog.

PMID- 1041525
TI  - Hepatic and peritoneal invasion by adult ascarids (Toxocara canis) in a dog.

PMID- 1041526
TI  - Repair of fractured radius and ulna in a brown bat.

PMID- 1041527
TI  - Malignant melanoma of the bulbar conjuctiva in a dog.

PMID- 1041528
TI  - Meibomian adenoma in a dog.

PMID- 1041529
TI  - Equine carpal fractures (a case report).

PMID- 1041530
TI  - Atrioventricular dissociation with synchronous diaphragmatic flutter in a horse.

PMID- 1041531
TI  - Critical and controlled tests of the antiparasitic activity of liquid and paste
      formulations of trichlorfon in the horse.

PMID- 1041532
TI  - A practical approach to prolapsing the bovine eye for treatment of corneal
      lesions.

PMID- 1041534
TI  - Ventilation systems for swine housing.

PMID- 1041533
TI  - Clinical and laboratory diagnosis of enterotoxemia of cattle.

PMID- 1041535
TI  - The power of positive reinforcement.

PMID- 1041536
TI  - [Determination of uropepsin as an indicator of phase conditions of the body
      reactivity in immunotherapy].

PMID- 1041537
TI  - Can family life survive?

PMID- 1041538
TI  - Struggling out of the feminine pluperfect.

PMID- 1041539
TI  - Family planning democratized.

PMID- 1041540
TI  - Developing maternity services women will trust.

PMID- 1041541
TI  - Birth is a family affair.

PMID- 1041542
TI  - A midwife-physician team in private practice.

PMID- 1041543
TI  - When a high-risk infant is born.

PMID- 1041544
TI  - The nature of well child care.

PMID- 1041545
TI  - Demystifying adolescent behavior.

PMID- 1041546
TI  - The adolescent process and the problem of nutrition.

PMID- 1041547
TI  - Prevention and treatment of sports injuries.

PMID- 1041548
TI  - Diabetes in adolescence.

PMID- 1041549
TI  - Conscious repatterning of human behavior.

PMID- 1041550
TI  - The quality of the work environment.

PMID- 1041551
TI  - Occupational safety and health.

PMID- 1041552
TI  - Mid-life crises.

PMID- 1041553
TI  - The case for and against estrogen therapy.

PMID- 1041554
TI  - All American sexual myths.

PMID- 1041555
TI  - Making the most of the middle years.

PMID- 1041556
TI  - Living with chronic respiratory disease.

PMID- 1041557
TI  - The potential for suicide.

PMID- 1041558
TI  - The search for spiritual meaning.

PMID- 1041559
TI  - Listen to the aged.

PMID- 1041560
TI  - There are no routine patients.

PMID- 1041561
TI  - Safe self-medication for elderly outpatients.

PMID- 1041562
TI  - Hospital-based home care.

PMID- 1041563
TI  - Nurses and nursing's issues.

PMID- 1041565
TI  - International foundations and the development of higher education in developing
      countries.

PMID- 1041564
TI  - What business structure is best for you?

PMID- 1041566
TI  - International foundations and the development of health services in
      underprivileged areas.

PMID- 1041567
TI  - The future of philanthropic foundations. The next twenty-five years.

PMID- 1041568
TI  - The influence of science and technology on medicine: a forecast.

PMID- 1041570
TI  - Symposium on the future of philanthropic foundations. Summing up.

PMID- 1041569
TI  - The future of foundations: the Jeffersonian potential.

PMID- 1041571
TI  - Foundation and the State in the Federal Republic of Germany: some comments.

PMID- 1041572
TI  - The moral and social responsibilities of the trustees of foundations.

PMID- 1041574
TI  - Independence and experiment: the experience of the Wellcome Trust.

PMID- 1041573
TI  - The role of the foundation trustee.

PMID- 1041575
TI  - The means to the ends of the Rockefeller Foundation.

PMID- 1041576
TI  - On the selection of priorities for an emerging foundation of national scope.

PMID- 1041577
TI  - Didactic vectorcardiography: general concepts.

PMID- 1041578
TI  - Postcardiotomy psychosis: indications and interventions.
AB  - Aberrant psychological behavior has become a frequent occurrence in the intensive
      care unit (ICU). In specifically considering postcardiotomy psychosis, health
      professionals puzzle whether the manifestations are motivated by physiological
      problems imposed by surgical considerations (cardiac status, pump perfusion)
      and/or by pre- and postoperative psychological factors. Current literature
      attempts to isolate elements which may predispose patients to develop these
      aberrant behaviors. This paper attempts to identify important areas and suggest
      concrete nursing interventions to decrease, delay, and assimilate these behaviors
      in the cardiotomy patient.

PMID- 1041579
TI  - Emotional response and clinical severity as early determinants of six-month
      mortality after myocardial infarction.
AB  - The literature relating psychic factors to pathogenesis, onset, and complication
      of acute myocardial infarction was selectively reviewed. A study which suggests
      that psychic factors affect six-month mortality rate after myocardial infarction
      was described. Specifically, patients showing a trend toward emotional adjustment
      early in their hospitalization had a far smaller mortality rate than those who
      did not show early adjustment trends. Severity of the heart attack, measured by
      the extent of complication, proved also to be predictive of six-month mortality.
      The findings were discussed with an emphasis on the acute-care staff's potential
      for changing patient behavior patterns, and hence, improving eventual patient
      mortality rates.

PMID- 1041580
TI  - Emotional and behavioral reaction to acute myocardial infarction.

PMID- 1041581
TI  - Psychosocial influences on heart rhythm in the coronary-care unit.
AB  - This report is an extension of previous studies which have shown that significant
      heart rate and rhythm changes can occur in coronary-care patients during a
      variety of socio-clinical interactions. Results of continuous day-long
      observations and concurrent monitoring of one such coronary-care patient
      disclosed that twice as many ectopic beats occurred during routine nursing
      interactions compared to resting periods, even though such interactions accounted
      for less than half of the total observation period. These results are similar to
      previous studies that have shown that the frequency of ectopic beats can be
      significantly altered in coronary-care patients by such routine interactions as
      pulse palpation. Combined with other clinical and animal studies, these data
      suggest that psycho-social interactions can have major effects on cardiac
      functioning.

PMID- 1041582
TI  - Family conferences as an adjunct to total coronary care.

PMID- 1041583
TI  - Hemorrhagic cardiac tamponade complicating the postmyocardial infarction syndrome
      in the absence of anticoagulation.

PMID- 1041584
TI  - The case for intensive care in hepatic coma.

PMID- 1041585
TI  - Idionodal tachycardia "unmasked" by carotid sinus pressure.

PMID- 1041586
TI  - Sinus bradycardia leading to atrial escape.

PMID- 1041587
TI  - Home oxygen therapy for the COPD patient.

PMID- 1041589
TI  - Letter: Stress on the nurse and therapist in the intensive-care unit and the
      coronary-care unit.

PMID- 1041588
TI  - Arrhythmias in the coronary-care unit. II. Physiologic bases of paroxysmal
      bradycardia-dependent A-V block.
AB  - Bradycardia-dependent A-V block during acute cardiac ischemia or injury is best
      explained by applying knowledge of basic cellular electrophysiology. Spontaneous
      diastolic depolarization during phase 4, plus a reduction in the magnitude of the
      transmembrane action potential are the pathophysiologic changes responsible for
      "phase-4 block".

PMID- 1041590
TI  - Evaluation of the pathotec Rapid I-D system for identification of
      Enterobacteriaceae.
AB  - The PathoTec Rapid I-D System for identifying Enterobacteriaceae was evaluated
      with 471 cultures. In 4,910 individual test comparisons, 95.5% of the results
      agreed, with results of only two test strips, those for esculin hydrolysis and
      urease production, agreeing with conventional tests in less than 94% of the
      trials. The PathoTec system exhibited 94.3% accuracy in identifying these
      cultures in a double-blind study with conventional media and procedures as the
      alternate system. Two newly developed test strips, for 0-nitrophenyl-beta-D
      galactopyranoside and ornithine decarboxylase, were found to be highly reliable.

PMID- 1041591
TI  - Microwave bean roaster.

PMID- 1041592
TI  - Effect of 2450 MHz microwave radiation on horseradish peroxidase.

PMID- 1041593
TI  - Microwave and infra-red effects on heart rate, respiration rate and subcutaneous
      temperature of the rabbit.

PMID- 1041594
TI  - Electromagnetic fields and skin wound repair.

PMID- 1041595
TI  - Dielectric food data for microwave sterilization processing.

PMID- 1041596
TI  - The use of microwave heating to control insects in cigarette manufacture.

PMID- 1041597
TI  - Exposure of the Japanese Quail embryo to 2.45 GHz microwave radiation during the
      second day of development.

PMID- 1041598
TI  - Sensitivity of fresh isolates of Haemophilus to current antibiotics.

PMID- 1041599
TI  - The community mental health system: is it an improvement over the old system?

PMID- 1041601
TI  - Socializing hospitalized patients into the psychiatric sick role.

PMID- 1041600
TI  - The relationship between psychoanalysis and the community mental health program.

PMID- 1041602
TI  - Return to society: problematic features of the re-entry process.

PMID- 1041603
TI  - Film or television?

PMID- 1041604
TI  - Editorial: What bugs editors.

PMID- 1041605
TI  - The new accountability.

PMID- 1041606
TI  - Accountability and nursing education.

PMID- 1041608
TI  - Alcoholism in fiction: learning from the literature.

PMID- 1041607
TI  - A nursing school cooperative.

PMID- 1041609
TI  - Evaluation of nursing care in terms of process and outcome: issues in research
      and quality assurance.
AB  - Approaches to patient care evaluation (process, outcome, and process-outcome) are
      placed in perspective and organized into a framework which clarifies the need for
      working toward the goal of process-outcome evaluation. Some issues of interest to
      researchers and to quality control programs are discussed, and recommendations
      are made.

PMID- 1041610
TI  - Role insufficiency and role supplementation: a conceptual framework.
AB  - A theoretical basis for the diagnosis of nursing problems, centered on the
      concepts of role insufficiency and role supplementation, is offered. Role
      insufficiency is anticipated and experienced by clients during role transitions
      with developmental, situational, and health-illness implications. The conceptual
      basis of nursing intervention is role supplementation, and components,
      strategies, and processes of role supplementation are described. Conditions that
      predispose clients in the health setting to undergo role transition, conditions
      under which aspects of role transition may become nursing problems, and the role
      of the nurse in dealing with clients' role transition problems are described. A
      predictive and prescriptive paradigm, showing the interaction of construct
      components, is presented.

PMID- 1041611
TI  - The impact of a professional baccalaureate degree program.
AB  - Results of a five-year investigation at the University of San Francisco of the
      impact-as measured by the students' perceptions of their collegiate experience-of
      an innovative four-year curriculum, leading to a bachelors degree and
      professional preparation in nursing, are summarized.

PMID- 1041612
TI  - Factors contributing to child abuse.
AB  - Medical data of 48 children up to six years of age who were hospitalized at a
      public children's hospital for battering between 1965 and 1973 were compared with
      a random sample of comparable data of 50 nonbattered children. The average age of
      the battered children was 15.5 months. No differences were found between abused
      and nonabused children on study questions.

PMID- 1041613
TI  - Direct tape access as an adjunct to learning.
AB  - In a study to ascertain effect of direct tape access as an adjunct to learning,
      junior nursing student in a course in epidemiology were divided into control and
      experimental groups. The study extended through three quarters--fall, winter, and
      spring. Experimental students in the winter and spring quarters were given access
      to 15-minute taped summaries of each week's lecture. When midterm and final
      examination scores were analyzed according to study group, no statistically
      significant differences between control group scores and experimental group
      scores were computed, so that the tapes were found to have no effect on learning;
      however, student satisfaction with the course showed a significant increase.

PMID- 1041614
TI  - Developing a computer program to assist the nursing process: phase I-from systems
      analysis to an expandable program.
AB  - In a three-stage project, a computer program was devised to assist in the nursing
      process. As Stage I, a definition of nursing was developed upon which a systems
      model of the nursing process was constructed. In Stage II, the computer program
      was written to collect patient data and formulate nursing diagnoses related to
      functions of the skin, mucous membranes, nails, and hair. The program was
      designed to serve as a model for the development of a more comprehensive program
      that would include other functional areas, suggest patient objectives and nurse
      interventions, and help to evaluate nursing care. In Stage III, initial trials
      were conducted to obtain feedback from nurses. Nurses found the program took too
      long but agreed that with modification it could help them give better care.

PMID- 1041615
TI  - Editorial: The invisible university.

PMID- 1041616
TI  - Extra tactile stimulation of the premature infant.
AB  - To ascertain whether touch, in the form of extra tactile stimulation, would
      result in more rapid physical and social development and a greater degree of
      social development of the premature infant, 48 minutes of extra tactile
      stimulation, defines as a gentle, nonrhythmic stroking of the greatest possible
      area of skin surface of the infant's body by the nurse's hand, was given to eight
      experimental group premature infants daily for a minimum of two weeks while they
      were confined to an isolette. Six infants formed a control group. Regain of birth
      weight was used to assess physical development. Scores on the applicable portions
      of the Gesell Development Schedule and Bayley Scales of Infant Development and
      plasma cortisol levels were used to measure rate and degree of social
      development. Data were analyzed in terms of the total group and for pairs of
      infants matched for gestational age, birth weight, and Apgar score. No
      significant difference was found between control and experimental groups in rate
      of physical development as measured by regain of birth weight. Analysis of the
      relationship between weight gain and gestational age, sex, and Apgar scores
      indicated that none was a substantial indicator of the rate at which infants
      gained weight while in the hospital. There was no significant difference in the
      degree of social development between experimental and control infants, but, as
      hypothesized, there was significant difference in rate of social development.
      Plasma cortisol levels as an indication of the infant's adrenocorticol
      development as evidenced by his ability to respond to stressful situations, and
      hence indirectly his social development, revealed no significant difference
      between the two groups.

PMID- 1041617
TI  - Patient attitudes toward nursing interventions.
AB  - When attitudes toward nursing interventions of 103 psychiatric inpatients studied
      over a 28-month period, in three different ward phases, were correlated with
      demographic, psychiatric, and psychologic test variables, attitudes varied
      premirily and almost exclusively with ward administrative phase. Within the
      differing ward phases the nursing interventions most valued by patients did not
      focus directly upon the individual patient.

PMID- 1041618
TI  - A hospital stress rating scale.
AB  - When 261 medical and surgical patients at a community hospital were asked to rank
      order 49 events related to the experience of hospitalization from most to least
      stressful, results indicated the subjects were capable and willing to order the
      events. Moreover, they showed a high degree of consensus as to how the events
      should be ordered. The rank order of these events provides a tool that can be
      used to quantify the measurement of psychosocial stress experienced by hospital
      patients.

PMID- 1041619
TI  - Nursing assessment and care plan statements.
AB  - Scope, specificity, and interrelatedness of patient problem and nursing
      intervention statements on nursing care plans were studied in relation to the
      introduction into the nursing assessment process of an objective observation
      checklist and a nursing history form. Ninety nursing care plans from six
      inpatient units in a Veterans Administration hospital were studied over an 11
      month period. Results indicated that significant increases in the numbers of both
      types of care plan statements occurred only following the introduction of the
      nursing history, as did the numbers of nursing interventions related to the
      identified patient problems. The degree of specificity among the problem
      statements increased, but nursing interventions tended to become less explicit.
      The scope of focus of both types of statements continued to be primarily physical
      in orientation. The findings also suggested that, since the care plans reflected
      less than half the patient problems identified on the nursing histories, care
      plan studies alone might not be appropriate for evaluating the breadth of nursing
      care planning.

PMID- 1041620
TI  - Effect of simulation gaming on attitudes toward mental illness.
AB  - Sixty nursing students were administered the Opinions about Mental Illness (OMI)
      scale. Students whose scores fell above the median on authoritarianism and social
      restrictiveness were randomly assigned to experimental and control groups. The
      experimental subjects' scores on authoritarianism and social restrictiveness
      decreased significantly (p greater than .001), wheras the control  groups' scores
      on these two factors remained essentially the same.

PMID- 1041621
TI  - Measurement of Nursing Work Load Using Head Nurses' Perceptions.
AB  - A methodology for measuring and  predicting work load on nursing units utilizes
      perceptions of head nurses as measured by a specially designed questionnaire. The
      data were collected in a 300-bed shortterm general hospital over a seven week
      period. The results indicated that head nurses' perceptions of need on nursing
      units were predominantly influenced by unit census and available staff on the
      unit. Other patient load affecting variables, such as patient classification,
      number of new admissions, or postoperative patients, did not play a major role in
      shaping head nurses' perceptions.

PMID- 1041622
TI  - Development of a patient-completed admission questionnaire and its comparison
      with the nursing interview.
AB  - To compare the effectiveness of a patient-completed paper-and -pencil
      questionnaire with the nursing interview in obtaining the admission history, 30
      patients newly admitted to a Veterans Administration hospital were asked to
      complete a questionnaire and were given the routine nursing interview. Data were
      compared for accuracy and nursing time required. The nurses made significantly
      more errors of omission in an unstructured interview than the patient made in
      completing the questionnaire (p greater than .001). The nurse spent an average of
      11.5 minutes on her interview while the investigator used an average of 0.9
      minute to explain the reason for the questionnaire to the patient and obtain his
      consent to its completion. Study findings are discussed as a means of providing
      an accurate, systematic, recorded data base for planning nursing care.

PMID- 1041623
TI  - Comparing the body-systems and conceptual approaches to nursing education.
AB  - This study compared the teaching effectiveness of two approaches to curriculum
      organization-the body-systems approach (which organizes the nursing curriculum in
      terms of the different systems of the body) and the conceptual approach (which
      organizes the nursing curriculum in terms of overarching principles or concepts).
      It was hypothesized that the conceptual would be more effective than the body
      systems approach to nursing education, as measured by National League for Nursing
      (NLN) achievement tests and state board examinations for nursing licensure. The
      study, conducted in a small three-year diploma program in San Francisco, compared
      the Classes of 1970, 1971, and 1972 (N equals 70), which were taught on a body
      systems curriculum, with the Class of 1973 (N equals 26), which was taught on a
      concept-oriented curriculum. No statistically significant differences were found
      among graduates of the four classes on the basis of either entering I.Q. scores
      or high school grade point averages. Statistically significant differences were
      found, however, on later NLN achievement test and state board examination
      results. Although the Class of 1973 did not perform as well as the classes of the
      three preceding years, it was not possible to attribute the performance of the
      Class of 1973 to changes in curriculum. The results of the study, therefore, did
      not sustain the hypothesis, but were instead inconclusive.

PMID- 1041624
TI  - What is the difference between a research grant and a research contract, and how
      is information obtained on the contract approach?

PMID- 1041625
TI  - Symposium on care of the patient with renal disease. Foreword.

PMID- 1041626
TI  - Symposium on care of the patient with renal disease.

PMID- 1041627
TI  - Nursing care of the patient with acute renal failure.

PMID- 1041628
TI  - Osteodystrophy in patients with chronic renal failure.

PMID- 1041629
TI  - Current trends in diet and drug therapy for the dialysis patient.
AB  - It is virtually impossible to discuss diet and drug therapy separately in the
      treatment of the hemodialysis patient. Drugs and dialysis techniques often
      necessitate changes in dietary care, just as dietary indiscretions call for
      changes in drug therapy and dialysis. In order to coordinate the various facets
      when ordering diets, several factors must be considered. The physician plans the
      drug therapy with input from the dialysis nurses, especially for dialysis effects
      on salt, water, K+, and protein balance, and the dietitian coordinates the diet
      with drug and dialysis therapy. It is therefore essential that all personnel must
      interact as a team if the patient is to receive the maximum benefit of
      hemodialysis. To maintain this delicate, constantly changing approach, a balance
      of teamwork is essential.

PMID- 1041630
TI  - Large surface area dialysis; innovations and patient management.
AB  - The analysis of the middle molecule theory has provided a means for reduced time
      and large surface area dialysis. Increasing the time-surface area product for the
      dialysis patient has provided a challenge for the dialysis staff. Rapid
      ultrafiltration necessitates careful and constant monitoring of these patients to
      prevent complications such as hypotension and cramping. The use of multiple
      dialyzers to accomplish large surface area dialysis also increases the cost.
      However, reuse has become a practical and safe way of decreasing the cost without
      jeopardizing the efficacy of dialysis. Developing a dialysis prescription to meet
      the particular needs of each patient, based on middle molecule clearance and
      residual renal function, appears to be an important factor in the future of large
      surface area dialysis and its adequacy.

PMID- 1041631
TI  - Nursing in a limited care hemodialysis facility.

PMID- 1041632
TI  - Symposium on human sexuality. Foreword.

PMID- 1041633
TI  - Symposium on human sexuality.

PMID- 1041634
TI  - Sexual health education and counseling.
AB  - In the past decade, there has been a concentrated effort to develop much needed
      advances in human sexuality, but many sexually misinformed or troubled members
      remain in our society. As more information is disseminated and people become
      sophisticated, there will be many people requesting help with sexual problems in
      primary and secondary health settings. Nurses need to equip themselves in this
      important aspect of health care. First, one's own values, attitudes, and
      knowledge must be carefully examined. Desensitizing, and incorporatin experiences
      have been used effectively to help get in touch with feelings and attitudes about
      the sensitive area of sexuality. Second, the nurse must be aware of the wide
      range of feeling and attitudes on specific sexual issues that have proved
      troublesome to our society. Third, the nurse must take advantage of educational
      opportunities to gain knowledge of psychosexual growth and development during the
      entire life span. Fourth, if the nurse desires to become involved in sexual
      conseling further education with concentration on the various innoviative
      techniques and approaches will be necessary to help clients with specific
      problems and concerns. Finally, sexual health programs need to be affiliated with
      a reputable health agency with prefessional supervision. All programs and new
      approaches must be evaluated to determine their effect on sexual health care.

PMID- 1041635
TI  - Human sexual response patterns.

PMID- 1041636
TI  - Myths in human sexuality; a social-psychological perspective.
AB  - Human sexuality, as a field of interest as well as a human experience, is
      inundated with myths, falacies, and dead beliefs. These outdated notions are
      instrumental in failure to gain an accurate and factual knowledge base about
      human sexuality, its nature, function, and its regulation. Myths have served to
      create an aura and mystery around the expression and experience of human
      sexuality. It is that aura that has contributed to ignorance, abuse, and
      misunderstanding. It is imperative, therefore, to examine the existence of myths
      in everyday living and to explore the meaning in our personal lives as well as in
      our prefessional encounters.

PMID- 1041637
TI  - Sexual trauma of children and adolescents.

PMID- 1041638
TI  - Sexuality in later life.
AB  - Aging produces changes in sexual organs, in the strength of the secual urge, and
      in physiologic responses and psychologic tensions. While sexual interest ans
      sexual thought decline, they do not disappear. Availability of partners and
      retention of youthful attitudes are important elements of sexual interest and
      activity at older ages. All authorities seem to agree that regularity of sexual
      activity is the essential factor in maintaining sexual capacity and performances
      for both males and females. Older persons who are sexually inactive and
      comfortable with that adjustment should not be made to feel inadequate, but those
      who are struggling with sexual problems should be helped to overcome them. Nurses
      should be prepared to take an active role in sexual conseling of the elderly and
      in agitating for social, political, legal, and attitudinal change.

PMID- 1041639
TI  - Temporary sexual dysfunction in reversible health limitations.

PMID- 1041640
TI  - Bilateral divergent strabismus in a Holstein calf.

PMID- 1041641
TI  - Four cases of naturally-occurring canine ehrlichiosis.

PMID- 1041642
TI  - Staphylococcal septicemia in puppies (a case report).

PMID- 1041643
TI  - Extraskeletal giant cell tumor in a cat.

PMID- 1041644
TI  - Bilateral congenital polycystic kidneys with vague symptomatology in a dog (a
      case report).

PMID- 1041645
TI  - Adenocarcinoma of the cecum with plastic impaction in a dog.

PMID- 1041646
TI  - Surgical treatment of ruptured cranial cruciate ligament in the dog.

PMID- 1041647
TI  - Microsporum gypseum infection in a dromedary camel.

PMID- 1041648
TI  - Fatal hairball in a long-haired hamster.

PMID- 1041649
TI  - Experimentally-induced Streptococcus equi infection in horses with resultant
      guttural pouch empyema.

PMID- 1041650
TI  - Corrective hoof trimming for the foundered horse.

PMID- 1041651
TI  - Sterility denotations and a grading system for bovine reproducton.

PMID- 1041652
TI  - Calcinosis in sheep associated with C-cell adenoma of the thyroid.

PMID- 1041653
TI  - Comparative in vitro activity of gentamicin and other antibiotics against
      bacteria isolated from clinical samples from dogs, cats, horses and cattle.

PMID- 1041654
TI  - New nationwide rip-off: limited-edition, commemorative coins and medals.

PMID- 1041656
TI  - Talk your clients' language.

PMID- 1041655
TI  - Personal financial planning--1.

PMID- 1041657
TI  - Compulsory continuing education?

PMID- 1041658
TI  - Tetany in cattle.

PMID- 1041659
TI  - Use of melengestrol acetate (MGA) for improving reproductive performance of dairy
      cows.

PMID- 1041660
TI  - An inexpensive anesthesia reminder.

PMID- 1041661
TI  - Surgical repair of an anterior urethral laceration in a dog.

PMID- 1041662
TI  - A safe method of administering thiacetarsamide sodium for heartworm therapy.

PMID- 1041663
TI  - Prevention and treatment of decubital ulcers in the dog.

PMID- 1041664
TI  - A clinical evaluation of xylazine and ketamine HCL for cesarean section in the
      dog.

PMID- 1041665
TI  - Renal cortical hypoplasia in a Keeshond litter.

PMID- 1041666
TI  - Ocular allergies in dogs.

PMID- 1041667
TI  - Cosmetic removal of a sebaceous adenocarcinoma of the eyelid.

PMID- 1041668
TI  - A basal cell epithelioma in an African lion.

PMID- 1041669
TI  - Small colon impaction and rupture into the colic mesentery in a horse (a case
      history).

PMID- 1041670
TI  - Use of a topical enzymatic debriding agent in wounds of the equine leg (a pilot
      study).

PMID- 1041671
TI  - Tax tips for home owners.

PMID- 1041672
TI  - Is ITA limiting your professional success?

PMID- 1041674
TI  - The new life center.

PMID- 1041673
TI  - Patient assessment: neurological examination. Part 1. Programmed instruction.

PMID- 1041675
TI  - Realizing a dream.

PMID- 1041676
TI  - Spreading family-centered care.

PMID- 1041677
TI  - Renin and blood pressure.

PMID- 1041678
TI  - Human amniotic membranes for burns.

PMID- 1041679
TI  - Antimicrobial drug interactions.

PMID- 1041680
TI  - Outcome criteria to evaluate postoperative respiratory status.

PMID- 1041681
TI  - The forgotten grievers.

PMID- 1041682
TI  - A center for pediatric cardiovascular patients.

PMID- 1041683
TI  - Anticipating breast surgery.

PMID- 1041684
TI  - Strep screening to prevent rheumatic fever.

PMID- 1041685
TI  - Strep screening to prevent rheumatic fever: From project to ongoing program.

PMID- 1041686
TI  - Some thoughts on the psychology of the coronary care unit patient.

PMID- 1041687
TI  - Reaching out to pregnant adolescents.

PMID- 1041688
TI  - Hot-line for teen-age mothers.

PMID- 1041689
TI  - How do nurses feel when patients suffer?

PMID- 1041690
TI  - Watching your finances: what should you know before investing in stocks or bonds?

PMID- 1041691
TI  - Pressure volume curves of lamb lungs and the lecithin-sphingomyelin ratios of
      lung fluid.
AB  - Pressure-volume curves were made of lungs from non-distressed, from asphyxiated
      and from distressed lambs. The curves of the non-distressed animals differed from
      the curves of the asphyxiated and of the distressed group. Eleven stability
      indices were calculated and the summation of these in situ surfactant
      characteristics was used for individual respiratory distress syndrome diagnosis.
      Low values (less than 2) of lecithin/sphingomyelin (L/S) ratios in lung fluid
      were found before the 130th day of gestation, but a steep increase of the L/S
      ratio was present after that period. Postnatal RDS was found in low L/S ratio
      cases, whereas normal lung stability was noticed in animals with L/S ratios
      greater than 2. It is concluded that the prenatal L/S ratio in lung fluid of
      lambs is of predicting value in RDS experiments and fits well with lung stability
      characteristics.

PMID- 1041692
TI  - Kinetic studies of mold alpha-galactosidase on PNPG hydrolysis.
AB  - The kinetic properties of alpha-galactosidase of Mortierella vinacea were
      investigated in detail using PNPG (p-nitrophenyl-alpha-D-galactopyranoside) as a
      substrate. Consequently, the enzyme was markedly inhibited not only by the
      substrate, but also by the galactose hydrolized. The initial rate of reaction at
      sufficiently high substrate concentrations, however, did not fall to zero and did
      approach a finite value. Galactose behaved as a mixed inhibitor and was neither
      totally competitive nor totally noncompetitive. A rate equation was obtained from
      a generalized equation derived from a kinetic model which took both the
      inhibitions into consideration. The constants used in the equation were
      appropriately estimated. The calculated rate agreed fairly well with the observed
      initial rate. Moreover, the PNPG hydrolysis progressing in a batch system was
      found to be approximately representable by simple first order kinetics in which
      the rate constant was dependent on the initial substrate concentration.

PMID- 1041693
TI  - American law and the species problem in Cannabis: science and semantics.

PMID- 1041694
TI  - A study of kratom eaters in Thailand.

PMID- 1041696
TI  - Health and industrial growth. A Ciba Foundation Symposium. Preface.

PMID- 1041695
TI  - Thebaine variations between germplasm sources within one collection of Papaver
      bracteatum Lindl.
AB  - Plants of Papaver bracteatum Lindl. derived from different germplasm sources
      within one Iranian collection were grown for 18 and 37 weeks in the greenhouse
      and controlled environment chambers. Gas-chromatographic analyses showed
      significant differences between thebaine concentrations of root tissue for 18
      week-old plants, but not for 37-week-old plants. The two age groups did not
      differ in thebaine yield per unit of dry weight of root tissue. However, due to
      more profuse root growth, the total yield of thebaine from roots of the older
      plants was about four times that of the younger plants. Shoot thebaine
      concentrations differed significantly for 18- and 37-week-old plants. The over
      all mean thebaine concentration for shoots of older plants was nearly twice that
      of younger plants. The variation in thebaine concentrations in these plants
      suggested genetic differences between the germplasm sources. Thus, domestication
      of P. bracteatum will require selection of germplasm from within and between
      collections, for plants of the greatest economic potential.

PMID- 1041697
TI  - The impact of industrial growth on health in South-East Asia.

PMID- 1041698
TI  - Health of working populations in industrializing societies.

PMID- 1041700
TI  - Legislative protection of health at work in the UK.

PMID- 1041699
TI  - The industrialization of medicine.

PMID- 1041701
TI  - Health and industrial growth. Socio-environmental consequences of design.

PMID- 1041702
TI  - Environmental and social problems arising from industrial growth.

PMID- 1041703
TI  - Health and industrial growth. Influencing individual and public responses.

PMID- 1041704
TI  - A social anthropological approach to health problems in developing countries.

PMID- 1041705
TI  - Health and industrial growth. Conclusions.

PMID- 1041706
TI  - Legislation outside the factory: The British philosophy of pollution control.

PMID- 1041707
TI  - Lessen the industrial growing pains of developing countries by more effective
      aid.

PMID- 1041708
TI  - Industrial growth and nutrition.

PMID- 1041709
TI  - Health and industrial growth: The current Indian scene.

PMID- 1041710
TI  - [The acute visual hallucinosis in infancy. Clinical, neurophysiological and
      psychodevelopmental aspects and differential typology (author's transl)].
AB  - By introducing the definition "hallucinosis" (Wernicke) it has become possible to
      confine the psychoses of organic origin more closely. Therefore, this term should
      also be used in pediatry and pedopsychiatry in order to designate cases with
      corresponding clinical aspects. Thus, accordance to the phenomenological
      characteristics of such syndromes as described in this paper, it is justified to
      emphasize that the acute hallucinosis in children is a special type of disease as
      compared to other psychoses caused by exogenic influences in this age group. The
      10 case reports deal with visual hallucinoses which turned out to be
      characteristically different compared to those in adults. Hallucinating children
      at the age of 3 to 9 years predominantly visualized animals and legendary beings.
      Contrary to findings in adults, scenic and systematized visions were scarcely
      noticed, which psychodevelopmentally may be attributed to the fact that creative
      power in children is still little pronounced. Etiologically intoxications and
      infectious diseases were the cause for the visual hallucinations of the 10
      children described. In the development of visual hallucinations somatic and
      psychic factors are significant. They have been discussed on the basis of today's
      knowledge. As today, however, there exists no satisfactory theory concerning the
      conditions favoring the development of hallucinations. To explain the
      somatogenesis of visual hallucinations three theories have been outlined, based
      on the present neurophysiological findings. It has been worked out that
      especially in children emotion plays an essential role in the origin of
      hallucinations. In infancy and early school age, while rational control of
      reality is still suppressed to a great extent, domination of emotional life goes
      along with lack of differentiation. At the same time the difference between
      imagination and perception is still little precise; therefore, phenomena,
      impressing as hallucinations in the adult, occur with greater facility in
      children.

PMID- 1041711
TI  - [Transient global amnesia - a paroxysmal amnestic syndrome (author's transl)].
AB  - The Syndrome of Transient Global Amnesia is clinically characterized by a
      disorder of the ability to form memory engrams, appearing suddenly and lasting
      for several hours. Since the first papers on this syndrome by Bender (1956) and
      Fisher and Adams (1964) approximately one hundred cases of transient global
      amnesia have been described. Symptomatology, course, somatic findings and
      differential diagnosis are discussed with consideration of the literatur and
      three own observations. Regarding the etiology most authors discuss a transitory
      localized ischemia in the circulatory area of the vertebral-basilar artery
      system. Relapsing episodes occur less frequently than single episodes. In
      connection with this disorder characterized by the paroxysmal occurence and the
      episodic course, possible ways of genesis of amnesic syndromes are discussed.
      Theoretically three types of amnestic syndromes of organic origin may be
      differentiated: (1) amnesia in the frame of "function psychosis", i.e. of global
      mental deterioration caused by various diffuse brain function disorders; (2)
      amnesia caused by a combination of diffuse (function psychosis) and local brain
      function disorder; (3) purely local type of amnesia without function psychosis.
      In the combined type of amnesia a dissociation between the severity of memory
      disorders and relatively mild function psychosis is to be found. The importance
      of psychopathometric investigations, i.e. of quantitative determination of other
      mental dysfunctions besides memory disorder, for the interpretation of an amnesic
      syndrome is emphasized. Unfortunately these have not been possible in the cases
      described in this paper.

PMID- 1041712
TI  - The construction of an objective test to measure patient satisfaction.

PMID- 1041713
TI  - Work-life of the Israeli registered nurse.

PMID- 1041714
TI  - A study of nursing student values.

PMID- 1041715
TI  - Report of the ICN President, 1973-1975.

PMID- 1041716
TI  - Nursing's contribution to social psychiatry: a holistic approach to personhood.
AB  - The expanded role of the nurse in social psychiatry involves building upon the
      conventional role of the nurse to include a focus on health promotion and
      prevention as well as on the detection and treatment of illness. Nursing is
      strategically located and uniquely prepared to take on such a challenge. Nursing
      has long recognized the holistic nature of families and communities. Nursing
      assumes that families have rights and responsibilities which include
      participation in the solution to problems which they helped to create. Nursing
      has been sensitive to the interrelationship between social expectation and
      dysfunctional behaviour. In the expanded role, nurses have accepted the mandate
      to transform society, to act as social change agents, as family advocates, as
      champions of minorities and as facilitators of mental health, i.e., the promotion
      and maintenance of mental health as well as disease detection and restoration of
      health. With a focus on mental health teaching, mental health promotion and
      prevention, nursing has the potential for providing an essential, holistic, now
      missing, link in the delivery of mental health services.

PMID- 1041717
TI  - Antibacterial activity of combinations of cefazolin and semisynthetic
      penicillins.
AB  - The antibacterial activity of cephalosporin (CS) and semisynthetic penicillins
      was studied using CS-resistant strains of Escherichia freundii and Proteus
      morganii. A synergistic growth inhibitory action toward these microorganisms was
      demonstrated by a qualitative method and confirmed by a quantitative
      determination.

PMID- 1041718
TI  - Profits and perils of land investments.

PMID- 1041719
TI  - The myths in the medical malpractice mess.

PMID- 1041721
TI  - Editorial: Medical writing.

PMID- 1041720
TI  - Editorial: The changing face of diabetes.

PMID- 1041722
TI  - Presidential acceptance address.

PMID- 1041723
TI  - X-ray study of the appendix after oral administration of barium.

PMID- 1041724
TI  - Neurologic implications of ocular symptoms and signs.

PMID- 1041725
TI  - Tranverse abdominal incisions in gynecologic surgery.

PMID- 1041726
TI  - The orthomolecular approach to schizophrenia.

PMID- 1041727
TI  - The reversal by taurine of ouabain-induced arrhythmias and hypoglycemia.

PMID- 1041728
TI  - Propranolol hydrochloride: uses in present-day therapy.

PMID- 1041729
TI  - The accreditation process for colleges of osteopathic medicine.

PMID- 1041731
TI  - Educational standards for colleges of osteopathic medicine.

PMID- 1041730
TI  - The self-study process.

PMID- 1041732
TI  - Summary of grants and loans available to osteopathic medical students.

PMID- 1041733
TI  - The student loan funds.

PMID- 1041735
TI  - The new basic medical writing: introduction.

PMID- 1041734
TI  - Continuing medical education. Committee on continuing medical education.

PMID- 1041736
TI  - Unilateral axillary Hodgkin's disease: an indication for staging laparotomy?

PMID- 1041737
TI  - Crisis intervention in a disaster area: the Pennsylvania flood in Wilkes-Barre.

PMID- 1041738
TI  - Pneumatosis intestinales: a review of the literature and report of an unusual
      case.

PMID- 1041739
TI  - Emphysematous cholecystitis.

PMID- 1041740
TI  - Hemolytic disease of the newborn infant due to anti-k (Cellano) antibody: report
      of a case and review of the literature.

PMID- 1041741
TI  - Asymptomatic popliteal cysts.

PMID- 1041742
TI  - Hepatic calcification secondary to misplaced umbilical venous catheter: report of
      a case.

PMID- 1041743
TI  - Galactorrhea: past and present concepts.

PMID- 1041745
TI  - Cryosurgical hemorrhoidectomy: pros and cons.

PMID- 1041744
TI  - Betamethasone dipropionate: a new topical agent for the treatment of psoriasis.

PMID- 1041746
TI  - Proceedings: Histochemistry of rat muscle.

PMID- 1041747
TI  - Proceedings: Observations on the effects of nerve ischemia on nerve fibers and
      muscle.

PMID- 1041748
TI  - Update on ampicillin-resistant hemophilus influenzae.

PMID- 1041749
TI  - Pneumothorax as a function of gestational age: Clinical and experimental studies.
AB  - Infants with respiratory distress syndrome are especially prone to pneumothorax
      and pneumomediastinum as a complication of their disease. In a retrospective
      clinical analysis of a consecutively delivered population of infants with RDS the
      data suggested that the less premature infant with RDS was apparently more at
      risk to develop pulmonary rupture. This clinical observation was confirmed in
      postmortem studies in premature rabbits. The most immature group of lungs were
      relatively resistant to pulmonary rupture, owing to high surface forces. Toward
      term, surface forces were decreased as were lung tissue elastic forces, which
      predisposed to rupture at lower pressures.

PMID- 1041750
TI  - Treatment of aspiration pneumonia and primary lung abscess. Penicillin G vs
      clindamycin.
AB  - Aspiration pneumonitis and lung abscess generally involve anaerobic bacteria,
      which normally colonize the upper respiratory passages. The therapeutic response
      of these infections to parenteral penicillin G (49 patients) and parenteral
      clindamycin (35 patients) was compared to determine relative efficacy. No
      difference was discerned between these two agents in terms of time required for
      defervescence, roentgenographic clearing, and ultimate outcome. Seven patients
      with infections including Bacteroides fragilis were treated with penicillin G,
      and all responded well. These data indicate that penicillin G is the preferred
      agent for pulmonary infections involving anaerobic bacteria. Clindamycin is a
      suitable alternative for patients in whom penicillin G is contraindicated.

PMID- 1041751
TI  - The influence of pornography and violence on attitudes and guilt.

PMID- 1041752
TI  - A new school health services field experience program for student nurse-teachers.

PMID- 1041753
TI  - The effect of the teachers smoking behavior on their involvement in smoking
      education in the schools.
AB  - The smoking behavior and attitudes of public school teachers were studied to
      determine if the teachers' smoking behavior is related to their attitudes and
      behavior regarding students' smoking practice and smoking education in schools.
      The Northampton, Massachusetts, School System was studied, where 162 of the 194
      teachers randomly selected from various schools in the district completed the
      close-ended questionnaires administered and collected by the researcher. The
      study yielded a return rate of 83 percent. The results of the study showed that
      the general climate in school is one conducive to the establishment of a
      comprehensive smoking education program. It also indicates that the teachers'
      attitudes and behavior towards smoking education were closely related to their
      smoking  behavior. The ex-smokers were the most active group in attempting to
      initiate student smoking behavior change, while the smoking teachers were  the
      least active in this respect. Furthermore, pre-service and in-service teacher
      training programs in relation to smoking education were shown to be extremely
      sparse and ineffective in the past. This study suggests the need to strengthen
      pre-service and in-service teacher training programs in smoking education and to
      make smoking cessation programs available to those teacher who want to stop
      smoking.

PMID- 1041754
TI  - Drug and alcohol abuse education: opinions of school principals.

PMID- 1041755
TI  - The Louisiana strategy--an interdisciplinary approach to the programs of
      adolescent parenthood.

PMID- 1041756
TI  - Sex education background of selected students in Lousiana.

PMID- 1041757
TI  - Proceedings: Effect of streptolydigin on chromosome complements of human cells
      cultured in vitro.

PMID- 1041758
TI  - [Position of cyticholine in pneumologic therapy].
AB  - The position of cyticholine in lung lipid metabolism and hence in pneumological
      therapy (the subject of a personal hypothesis) is discussed. A summary is given
      of personal experimental work and papers read at the 1974 Padua meeting (11th
      December) held by the Societas Europae Physiologiae Clinicae Respiratoriae. It is
      shown that cyticholine may: 1) prevent the onset of acute neonatal respiratory
      distress; 2) improve chronic pneumogenous respiratory insufficiency; 3) prevent
      postoperative hypoventilation; 4) improve ventilation mechanics in hyperelastic
      lung syndromes; 5) increase the gas permeability of the air-blood barrier; 6)
      counterbalance the loss of surfactants caused by endobronchial aspiration in
      patients with tracheal tubes.

PMID- 1041759
TI  - The media center: Autotutorial instruction.

PMID- 1041760
TI  - Are problems in graduate nursing education unique?.

PMID- 1041761
TI  - Fitting the graduate program to the student.

PMID- 1041762
TI  - COGEN: Cooperative Graduate Education in Nursing.

PMID- 1041763
TI  - Who shall be admitted to graduate study?.

PMID- 1041764
TI  - Graduate education, as one dean sees it.

PMID- 1041765
TI  - Nursing research and graduate education.

PMID- 1041766
TI  - An extended master's degree program.

PMID- 1041768
TI  - An experience in participant observation.

PMID- 1041767
TI  - Modules in child nursing instruction.

PMID- 1041769
TI  - Editorial: Everybody's patient is nobody's patient.

PMID- 1041770
TI  - Social forces, feminism, and breastfeeding.

PMID- 1041771
TI  - Vietnamese evacuee camp: a learning environment.

PMID- 1041772
TI  - Why a conceptual framework?

PMID- 1041773
TI  - Triage: coordinated home care for the elderly.

PMID- 1041774
TI  - Educational preparation for nursing--1974.
AB  - Each year a report of some of the most recent statistics on nursing education
      appears in the September issue of Nursing Outlook. The data presented are derived
      from The National League for Nursing's annual survey of state-approved schools of
      nursing in the 56 jurisdictions of the United States. The programs surveyed
      include those which prepare for beginning practice in nursing (baccalaureate,
      associate degrees, diploma, and practical nursing); those graduate programs that
      lead to masters and doctoral degrees in nursing; and those baccalaureate programs
      that conduct nursing programs for registered nurses only. Data on the status of
      state-approved basic schools (new schools, closed schools, and changes in
      existing schools) are obtained in September of each year from the state boards of
      nursing. In October, questionnaires are mailed to each school of nursing, as well
      as to those nursing programs that do not require state board approval (masters
      and doctoral programs, and baccalaureate programs for registered nurses).
      Information is also obtained from irregularly conducted surveys of all four-year
      colleges and universities in the United States that do not have state-approved
      basic nursing baccalaureate programs. The data obtained include admissions and
      graduations for the preceeding academic year, admissions for the current fall
      term, and enrollments as of October 15. Other information, such as data on men
      and minority students, is collected every three years. In recent years,
      enrollment figures for students who were admitted with advanced placement status
      have also been collected. With few exceptions, the schools have been most
      cooperative in providing the data, making it possible for us to obtain a 100
      percent response rate for both registered nurse and practical nurse programs.

PMID- 1041776
TI  - Symposium on perspectives in operating room nursing.

PMID- 1041775
TI  - Sex education for the young.

PMID- 1041777
TI  - Applying the nursing process to patient care in the operating room.
AB  - Using the nursing process in operating room nursing helps to assure personalized,
      continuous, and integrated care for the surgical patient. The steps in the
      nursing process clearly demonstrate the role and functions of the O.R. nurse as a
      professional member of the surgical team and as a component of the health care
      system. By this means the patient is assured of protection and quality care.

PMID- 1041778
TI  - Assessment and communication for continuity of care for the surgical patient.

PMID- 1041779
TI  - A master nurse clinician for intraoperative care.
AB  - The intraoperative period has long been the missing link in the chain of
      continuity of care for the surgical patient. An intraoperative clinical nurse
      specialist who is able to work with patients, families, and health care team
      members preoperatively, intraoperatively, and postoperatively can effectively
      bridge the gap in care. Nursing care given to patients in the O.R. should be no
      different qualitatively from nursing care given sedated and/or unconscious
      patients in other nursing units. The C.N.S. in the O.R. can help make such care a
      reality through giving care to patients and families as a role model, directing
      care as an expert through written care plans or physical presence, doing formal
      and informal teaching of patients, families, and staff, and through research.
      Operationalizing the role of the C.N.S. for surgical patients during the
      intraoperative period requires the specialist to move out of the O.R. to assess
      patients and families preoperatively and to evaluate the postoperative results of
      care. Implementation of the specialist role in the O.R. clinical nursing setting
      is accompanied by the same frustrations and problems met by master clinicians in
      other nursing specialty areas.

PMID- 1041780
TI  - The new graduate in the operating room.
AB  - New graduate nurses today come to their first positions in nursing with varying
      knowledge bases and minimal clinical nursing skills. Gone are the days when new
      graduates begin functioning fully in a budgeted position on day one of
      employment. Mastery of psychomotor, cognitive, and affective skills necessary for
      nursing practice must be acquired through experience in the work situation. The
      more complex the clinical setting, the more stressful is the period of learning.
      The O.R. can be a highly stressful place. The need for anticipation, planning and
      organization to provide efficient care with meticulous attention to detail is
      coupled with the need to perform smoothly numerous technical skills. Safe,
      humanistic care cannot be implemented unless the nurse is also able to assess
      each patient's individual biopsychosocial status, and identify his unique nursing
      care needs. In order to learn to cope with this level of complexity, the neophyte
      nurse must be provided with a planned, supportive experiential learning situation
      that also provides the time necessary to achieve a beginning level of mastery.
      The program in Basic O.R. Nursing described here was one attempt to provide such
      an experience for new graduates.

PMID- 1041781
TI  - Controlling operating room-related infection in cancer patients.
AB  - This paper outlines the program for controlling surgical infections in one cancer
      research hospital dealing with a unique group of patients. Control must -begin
      before the patient comes to the surgical suite and must continue when the patient
      returns to the nursing unit. These patients are often elderly, debilitated, and
      receiving anti-cancer chemotherapy, and they undergo lengthy massive resections
      often requiring several procedures. Some of the guidelines that we have evolved
      over a long period may be helpful in stimulating others to establish, implement,
      or improve similar programs in their own units. It is obvious that any such
      programs will have to be tailored to meet the demands and personnel of each
      institution. The important thing is that each surgical department must work
      toward the goal of keeping postoperative mosocomial infection at the lowest
      possible rate.

PMID- 1041782
TI  - Play therapy: preparing the young child for surgery.
AB  - A child is not a miniature adult. His thought processes are pre-conceptual, pre
      logical, and characterized by many fantasies. The child needs concrete
      information about his impending surgery: (1) what will happen; (2) what is
      expected of him; (3) that he is not to blame for his illness or injury, and (4)
      where the organ to be removed or repaired is located and that no other body parts
      will be harmed. Play therapy is an effective method for providing tangible
      information about the surgical experience and simultaneously decreasing the
      child's fantasies and fears about the surgery.

PMID- 1041783
TI  - Symposium on community nursing in Canada.

PMID- 1041784
TI  - A program in continuing education for primary health care.
AB  - Influential recommendations have been made that preparation for expanded roles in
      primary health care be part of basic nursing education. Much of the learning
      required for the roles is already included in many, if not all, baccalaureate
      programs. Implementation of these recommendations implies that short "add-on"
      courses such as the one described here should be considered interim measures to
      upgrade skills and knowledge of present graduate nurses, both diploma and
      baccalaureate. For such measures, continuing education should be available in a
      variety of courses which could meet in a flexible manner the varying needs and
      objectives of diverse service settings. As the expectations of consumers and
      service settings change, and as roles and functions evolve, variations and
      modifications in course offerings can then continue. It would be expected that,
      with clearer perception of the role to be ascribed to nursing in primary health
      care, such course offerings could be based soundly on data derived from
      systematic study of the effect of nursing. It is anticipated that the experience
      and findings of this project may have a contribution to make to the development
      of future courses. The project showed encouraging results from a working
      collaboration of a variety of health care personnel in both instruction and
      evaluation, and demonstrated that such courses can involve a variety of students
      from a variety of relevant practice settings. It is also felt that the evaluation
      approaches and tools evolved hold promise, with further refinement, of
      contributing to the development of evaluative procedures.

PMID- 1041785
TI  - Task analysis of the clinically trained nurse (C.T.N.)

PMID- 1041786
TI  - The independent nurse practitioner. Alive and well and living in rural
      Saskatchewan.
AB  - At this point, it is impossible to express analysis of the data collected in
      concrete terms as the project will not be finalized until October, 1976. It is
      possible, however, to make some personal observations. Each nurse practitioner
      has been truly independent in carrying out her role in the community, influenced
      to a degree by the communities' felt need and the attitudes of other health
      professionals. All began practice with a heavy emphasis on diagnosis and cure
      rather than comprehensive care. As time evolves and the nurses feel more
      confident in their new role, some are continuing a cure orientation, and others
      are beinning to find that they have a unique dimension to add to health care
      services. Those who were professional "nurses" in the true sense of the word
      before the project began have not stopped being nurses, but have only become more
      competent professionals by recognizing and responding to the health needs of
      today.

PMID- 1041787
TI  - Community health nursing in Quebec.

PMID- 1041788
TI  - Community nursing in a Northern setting. A challenge.

PMID- 1041789
TI  - Rebel with a cause.

PMID- 1041790
TI  - The community clinical nurse specialist. A two-year perspective.
AB  - I have described my role as a clinical nurse specialist in an official agency
      over the past two years. The circumstances of my setting and position, my
      personal feelings of commitment and accountability, have all influenced the
      direction of my position. In relation to my nursing practice, I have concentrated
      on areas that have appeared to me as high-risk. I believe that there is a very
      definite role in the community for nurses who have the expertise to deliver
      health care of a high quality with more independence than usually exists in a
      nursing role. Before a clinical nurse specialist can function in an official
      agency, however, there are limitations that must be resolved.

PMID- 1041791
TI  - The role of the nurse working with employment upgrading programs.
AB  - Working in a project where there are general objectives but no fixed program to
      reach them can be both a challenge and a frustration. But this work is never
      dull. The key points in the success of such a program are defined behavioral
      objectives for each student, an imaginative, flexible, and versatile nurse, and
      an administrative structure which is prepared to be flexible enough to say, "Do
      our thing your way."

PMID- 1041792
TI  - A survey of the "care-cure" attitudes of physicians, nurses and their students.

PMID- 1041793
TI  - Sensitivity training: a step toward involvement with patients.

PMID- 1041794
TI  - A creative approach to individualized nursing care.

PMID- 1041795
TI  - The alcoholic: an unperson?

PMID- 1041796
TI  - The child's developing concept of death: implications for nursing care of the
      terminally ill child.

PMID- 1041797
TI  - The terminal hepatic microcirculation in the rat.
AB  - The hepatic microcirculation was observed microscopically in the transilluminated
      liver of the rat. The portal and hepatic venous microvessels were classified into
      four orders according to their branching hierarchy, and the hepatic sinusoids
      into branching, direct and interconnecting types according to their topographic
      arrangements. The diameters of the various orders of microvessels and types of
      sinusoids were measured by serial photomicrography, and the velocity of the
      erythrocytes in these various microvessels and sinusoids by the dual-slit
      photometric technique. The microvascular volume flows were calculated from these
      data. In both portal and hepatic venous systems, the erythrocyte velocity and the
      volume flow significantly decreased in successive orders of the microvessels in
      apparent relation to the cross-sectional areas. The diameters of the three types
      of sinusoids did not significantly differ, but the velocity of the erythrocytes
      in the direct sinusoid was significantly faster than that in the branching
      sinusoid while that in the inter-connecting sinusoid fluctuated widely.

PMID- 1041798
TI  - Changes in the metabolism of the shivering hind leg of the young ox during
      several days of continuous cold exposure.
AB  - The effect of 4 days of continuous exposure to a cold environment on blood flow
      in, and oxygen and energy substrate uptake by the shivering hind leg has been
      studied in young steers. The animals shivered throughout the period of cold
      exposure and total oxygen consumption (total VO2) remained 40-50% greater than
      VO2 during thermoneutrality. Leg blood flow (leg Q) and oxygen uptake (leg VO2)
      increased two- and four-fold respectively on the first day of cold. Both had
      declined significantly by the final day, leg Q to a level 37% greater than, and
      leg VO2 to about double, pre-cold levels. The change in the relationships of leg
      Q and leg VO2 to total VO2 was examined by linear regression analysis, which
      suggested that the changing contribution of leg VO2 to total VO2 was entirely due
      to changes in leg Q, rather than in the arteriovenous difference in blood
      oxyhaemoglobin saturation across the leg. The net uptakes by the leg of free
      fatty acids (FFA), acetate, glucose and lactate all increased on the first day of
      cold. Both glucose and acetate uptakes were greater on day 4 than on day 1 in the
      cold, in spite of the lower leg VO2, but net uptakes of FFA and lactate were
      considerably lower. The decrease in net uptake of FFA is attributed mainly to an
      increase in the rate of lipolysis and release of FFA from fat depots in the leg,
      because of the associated progressive increase in the release of glycerol and
      oleic acid from the leg. The molar ratios of net carbohydrate substrate, acetate
      and FFA uptakes to leg VO2 are compared. The results suggest that tissues other
      than the leg muscles become increasingly important as sites of heat production,
      and that there are changes in the utilization of glucose, acetate and FFA by
      shivering muscle, during prolonged cold exposure.

PMID- 1041799
TI  - The effects of vagotomy on ventilation and blood gas composition in dog, sheep
      and rabbit.
AB  - The influence of vagotomy on resting arterial blood gases (PaCO2 and PaO2) and on
      the ventilatory responses to hypercapnia and hypoxia was studied in three
      different species of anaesthetized animals. After bilateral cervical vagotomy
      resting PaCO2 generally declined. In the dog, where this was studied more fully,
      resting PaCO2 declined significantly (8-13 +/- 0-67 mm Hg) over several hours,
      but PaO2 changes were not significant. After vagotomy tidal volume (VT), but not
      frequency (f), increased with increasing chemical drive. It is concluded that the
      increase in frequency in response to increased CO2 or decreased O2 is dependent
      on the vagal mechanisms. Minute volume, fractional inspiratory CO2 (VE, FICO2)
      and minute volume, fractional inspiratory O2 (VE, FIO2) relationships have been
      determined. Although vagotomy may not decrease the response of minute volume of
      ventilation in the lower part of VE, FICO2 curves (mild hypercapnia), it
      flattened the upper parts of the curves in sheep and rabbits, and to a lesser
      extent in dogs; it seemed that there was little species difference in this
      respect. Ventilatory responses to graded hypoxia were close to or slightly higher
      than pre-vagotomy values throughout the VE, FIO2 curves in all animals.

PMID- 1041800
TI  - Renal regulation of phosphate excretion in the pig.
AB  - Young pigs of about 25 kg in weight were given supplements of Na2HPO4 either in
      their food or by intravenous infusion and the effects on urinary phosphate
      excretion were studied. The results obtained showed that the amount of inorganic
      phosphate excreted in the urine increased with increase in the amount of
      phosphate filtered at the glomerulus. A threshold value for phosphate excretion
      in these pigs occurred at a plasma concentration of 2-03 mmol/l. while over a
      wide range of filtered phosphate load (0-21-1-14 mmol/min) phosphate was
      reabsorbed at a mean maximum rate of 0-19 mmol/min. Parathyroidectomy did not
      alter the relationship between phosphate excretion and filtered phosphate load
      which suggests that in the pig adjustment of renal phosphate excretion in
      relation to filtered load is not dependent upon parathormone.

PMID- 1041801
TI  - Mast cells and gastric secretion in the rat.
AB  - Gastric secretion of acid was measured in adult rats deprived of solid food for
      48 hr. In control animals, values were obtained for the residual content of acid
      in the stomach, indicative of the rate of basal secretion, and for the quantities
      of acid secreted in 30 min following injections of histamine, pentagastrin,
      insulin and compound 48/80. The same measurements were made in groups of rats
      treated for 5 days with compound 48/80 (a regime which depleted the whole body of
      mast cells) and for 3 days with dexamethasone (which selectively depleted the
      gastric mucosa of mast cells). The content of residual acid was depressed to one
      third of the control value in the 48/80-treated rats, but the additional
      secretion due to histamine, pentagastrin or insulin was unaffected. A secretory
      response to a single injection of compound 48/80 could not be obtained in rats
      depleted of mast cells. In the dexamethasone-treated rats, the residual level of
      acid was increased to 1-5 times the control value, but the magnitudes of the
      responses to secretogogues were unchanged. It is concluded that basal secretion
      of acid into the stomach of the rat is stimulated by histamine derived from mast
      cells throughout the body, those of the gastric mucosa having no special
      significance in this respect. Mast cells are not involved in the mediation of the
      secretagogue actions of exogenous histamine, pentagastrin and insulin, but the
      present results do not preclude the participation of histamine from sources other
      than mast cells in the process of gastric secretion.

PMID- 1041802
TI  - Secretory responses to sympathetic stimulation of the cat's salivary glands in a
      state of resting secretion.
AB  - The secretory effect of sympathetic stimulation on the cat's submaxillary gland
      was augmented greatly when studied against a background of slow secretion evoked
      by parasympathetic stimulation at a low frequency and imitating the slow resting
      secretion normally present in the waking state. The sympathetic secretory
      threshold was markedly lowered, and even at low frequencies sympathetic
      stimulation caused a large, well-maintained response. After an alpha-adrenoceptor
      blocking drug sympathetic stimulation alone lost its secretory effect, but during
      resting secretion part of the accelerating effect was found to remain; this
      effect was elicited via beta-adrenoceptors. A marked secretory effect of
      sympathetic stimulation was also obtained during resting secretion in the parotid
      gland, where the sympathetic secretory effect is normally very small.

PMID- 1041803
TI  - Aortic-iliac-femoral thrombosis in a horse.

PMID- 1041804
TI  - Ethmoidal hematoma in the horse.

PMID- 1041805
TI  - Equine joint surgery in the standing position.

PMID- 1041806
TI  - Evaluation of ComBotTM (Trichlorfon) when combined with phenothiazine,
      mebendazole or thiabendazole for use as a broad-spectrum anthelmintic in horses.

PMID- 1041807
TI  - Successful acupuncture treatment of a cervical disc syndrome in a dog.

PMID- 1041808
TI  - Aortic homograft for repair of septal defect in the heart.

PMID- 1041809
TI  - Hypertrophic osteoarthropathy secondary to neurofibrosarcoma of the urinary
      bladder in a Cocker Spaniel.

PMID- 1041810
TI  - Responses of cats to ketamine-antibiotic combinations.

PMID- 1041811
TI  - A screening test for canine atopic dermatitis.

PMID- 1041812
TI  - Unusual case of heartworm disease in a cat.

PMID- 1041814
TI  - Patent ductus arteriosus in three Great Dane puppies (a photographic essay).

PMID- 1041813
TI  - Tension-band wiring of a fractured patella (a photographic essay).

PMID- 1041815
TI  - Intrascrotal testicular torsion in a sexually agressive dog.

PMID- 1041816
TI  - Congenital cataracts in a Persian kitten (a case report).

PMID- 1041817
TI  - Palpation of the genital tract for prediction of estrus in the cow.

PMID- 1041818
TI  - Biotin in the nutrition of pigs.

PMID- 1041819
TI  - Vasectomy: solution to the overpopulation problem in captive African lions?

PMID- 1041820
TI  - Arizona septicemia in three boa constrictors.

PMID- 1041822
TI  - Personal financial planning--II.

PMID- 1041821
TI  - Ways to save on your 1975 taxes.

PMID- 1041823
TI  - How safe is your safe-deposit box?

PMID- 1041824
TI  - Help clients remember by writing it down.

PMID- 1041825
TI  - The New York plan.

PMID- 1041826
TI  - Oral care of the patient having head and neck irradiation.

PMID- 1041828
TI  - Helping patients with endotracheal and tracheostomy tubes communicate.

PMID- 1041827
TI  - Accepting disfigurement when death is the alternative.

PMID- 1041829
TI  - Electronic larynx for aphonic patients.

PMID- 1041830
TI  - Personal notes of a laryngectomee.

PMID- 1041831
TI  - Through a GLASS darkly.

PMID- 1041832
TI  - Coping with newly diagnosed blindness.

PMID- 1041833
TI  - Books for the hospitalized child.

PMID- 1041835
TI  - How I spent my Christmas vacation.

PMID- 1041834
TI  - Making vegetarian diets nutritious.

PMID- 1041836
TI  - Nurse in a Christian community.

PMID- 1041837
TI  - Multiple assignments-try them!

PMID- 1041838
TI  - The oxygen hood for newborns in respiratory distress.

PMID- 1041839
TI  - Strengthening a disorganized family.

PMID- 1041841
TI  - Watching your finances: is joint ownership the answer for you?

PMID- 1041840
TI  - Initiation into peer review.

PMID- 1041842
TI  - Letter: Penicillin-"sensitive" methicillin-resistant staphylococcus aureus.

PMID- 1041843
TI  - Hypertension Part II: Treatment and nursing responsibilities.

PMID- 1041844
TI  - Management of the disruptive patient in the intensive care setting.

PMID- 1041845
TI  - [Development of the KJ method - its application in nursing (from training in
      problem-solving to theorization of the clinical situation)].

PMID- 1041846
TI  - [Contemplation on the attitude to death by a nurse - with the research of the
      literature on the subject].

PMID- 1041847
TI  - [Simultaneous evaluation of actual nursing activities by the individual nurse and
      by the nursing team - restructuring of individual nursing scenes using the KJ
      method].

PMID- 1041848
TI  - [Learning about dying].

PMID- 1041849
TI  - [3 medical students confront death in a pediatric ward].

PMID- 1041850
TI  - [Life issues surrounding death education].

PMID- 1041851
TI  - [Impressions by the members of the literature research team on attitude to
      death].

PMID- 1041852
TI  - [Further thoughts on W.H.O.'s mission].

PMID- 1041854
TI  - Nursing in Ireland.

PMID- 1041853
TI  - [Making life worth living for the elderly].

PMID- 1041855
TI  - Declaration on procured abortion.

PMID- 1041856
TI  - [Classification of mental disturbances and psychiatric diseases].

PMID- 1041857
TI  - [Theme centered group therapy as a connecting link in the chain of therapy of
      psychiatric patients; report of an experience].

PMID- 1041858
TI  - [Nurse's role on a male psychiatric ward].

PMID- 1041859
TI  - [Cross-cultural psychiatry].

PMID- 1041860
TI  - [Between fetishism and aspirin. Medicine men of the 3d world as important
      assistants in public health].

PMID- 1041861
TI  - [Problems of role development and field of activity of the nurse specialist in
      psychiatry].

PMID- 1041862
TI  - [The education and continued education of teaching staff in the Netherlands].

PMID- 1041863
TI  - [Health education in the framework of current nursing legislation].

PMID- 1041864
TI  - [Health education from the viewpoint of the hospital ward].

PMID- 1041865
TI  - [Arithmatic samples from dietetics].

PMID- 1041866
TI  - [Suicide in children and adolescents].

PMID- 1041867
TI  - [Children in the hospital].

PMID- 1041869
TI  - [Basic observations on nursing care for Parkinson patients].

PMID- 1041868
TI  - [Parkinson's syndrome; epidemiology, clinical aspects and therapy].

PMID- 1041870
TI  - [Pathophysiology of circulatory arrest; physiology of resuscitation].

PMID- 1041872
TI  - [Rationalization in the field of nursing using organizational measures].

PMID- 1041871
TI  - [Functions of supervisory hospital nursing personnel; selected questions for
      hospital practice].

PMID- 1041873
TI  - [Continued ecuation for nurses in patient centered nursing/psychosomatic
      medicine; report of an experience].

PMID- 1041875
TI  - [Legal pension insurance, What every insured should know about it].

PMID- 1041874
TI  - [The care of a plaster cast using a rubber boot].

PMID- 1041876
TI  - [Hairy nevus in children].

PMID- 1041877
TI  - [Final examination nursing care study of a child with severe acidosis and
      concurrently a convulsion].

PMID- 1041878
TI  - [The truth at the patient's bedside].

PMID- 1041879
TI  - [The kidneys as the most important organs in the maintenance of a balanced
      electrolyte concentration in the body].

PMID- 1041880
TI  - [Current kidney function tests].

PMID- 1041881
TI  - [Dialysis patients and their environment. Observations on the psychological and
      social existence of a group of patients requiring assistance].

PMID- 1041882
TI  - [Treatment of the lungs using bronchial drainage].

PMID- 1041883
TI  - [A course to train nurse clinicians in anesthesia and intensive care in the
      Steglitz Hospital of the Free University of Berlin].

PMID- 1041884
TI  - [Neurosecretion and posterior pituitary gland hormones].

PMID- 1041885
TI  - [Educational goal in pediatric nursing].

PMID- 1041886
TI  - [Discussion on the reorganization of education in the nursing professions].

PMID- 1041887
TI  - [Draft of legislation on nonmedical health occupations in midwifery and nursing.
      315-4340 - 1/1 - situation on July 1st, 1975].

PMID- 1041888
TI  - [Individualized care].

PMID- 1041889
TI  - [Organization of nursing service].

PMID- 1041890
TI  - [Staff requirements in the hospital].

PMID- 1041891
TI  - [Observation by a first aid worker].

PMID- 1041892
TI  - [Continued education in nursing. Symposium for health occupations, male and
      female nurses on March 21-22, 1975 in Mainz].

PMID- 1041893
TI  - [Basic number of nursing personnel needed in a hospital].

PMID- 1041894
TI  - [The systems and nursing care in the hospitals].

PMID- 1041895
TI  - [Improvement of the quality of nursing care].

PMID- 1041896
TI  - [Systems theory].

PMID- 1041897
TI  - [Current use of the nursing care process in nursing services and education].

PMID- 1041898
TI  - [Mental health and the nursing school].

PMID- 1041899
TI  - [The process of nursing care].

PMID- 1041900
TI  - [Labor management in placenta previa and umbilical cord prolapse].

PMID- 1041902
TI  - [Analysis of the urine].

PMID- 1041901
TI  - [Fractures of the spine in elderly and senile patients (special features of
      diagnosis, clinical aspects and therapy)].

PMID- 1041903
TI  - [Diet in allergic diseases].

PMID- 1041904
TI  - [Anesthesia under first aid and emergency aid conditions].

PMID- 1041906
TI  - [Current methods in endoscopy].

PMID- 1041905
TI  - [Organization of control of injuries in rural districts].

PMID- 1041907
TI  - [Pharmacological preparations in surgery].

PMID- 1041908
TI  - [Alcohol and diseases of the cardiovascular system].

PMID- 1041909
TI  - [Control measures in noise].

PMID- 1041910
TI  - [Possible errors in vaccination].

PMID- 1041912
TI  - [Work in cold climatic conditions].

PMID- 1041911
TI  - [Organization of recording of and measures for the reduction of injuries in rural
      districts].

PMID- 1041913
TI  - [Industrial hygiene in the work with chemical poisons used in agriculture].

PMID- 1041914
TI  - [Hemolytic disease of the newborn infant].

PMID- 1041915
TI  - [Differentiation of acute appendicitis from ectopic pregnancy].

PMID- 1041916
TI  - [Diencephalic syndromes].

PMID- 1041917
TI  - [Vegetables and fruits in a diet].

PMID- 1041918
TI  - [Health instruction for pregnant women].

PMID- 1041919
TI  - [Experience in the organization of anti-alcoholic propaganda in an industrial
      plant].

PMID- 1041920
TI  - [Feldsher's role in prevention of industrial injuries in vessel builders].

PMID- 1041921
TI  - [Preventive and therapeutic functions of a health center].

PMID- 1041922
TI  - [Epidemiology and prevention of enteric infections].

PMID- 1041923
TI  - [Current diagnosis and treatment of diseases of the blood].

PMID- 1041924
TI  - [Multiple myeloma].

PMID- 1041925
TI  - [Prolonged subfebrile conditions in children].

PMID- 1041926
TI  - [Injuries of the chest].

PMID- 1041927
TI  - [Activities of the councils of public health feldshers and laboratory workers of
      the sanitary epidemiological stations of Moscow].

PMID- 1041928
TI  - [Experience in conducting the conference for parents of first-grade children:
      "The first time--to the first grade"].

PMID- 1041929
TI  - [Feldsher's role in the reduction of occupational injuries in a glass factory].

PMID- 1041930
TI  - [Illumination of schools].

PMID- 1041931
TI  - [Tasks in the field of occupational health at the BAM].

PMID- 1041932
TI  - [Methods of pesticide detection].

PMID- 1041933
TI  - [Disseminated lupus erythematosus].

PMID- 1041934
TI  - [Pyelonephritis in children].

PMID- 1041935
TI  - [Fractures of the extremities in old and senile patients].

PMID- 1041936
TI  - [Specific features in the course of pregnancy and labor in elderly primipara].

PMID- 1041937
TI  - [First aid in frontal sinusitis].

PMID- 1041938
TI  - [The Olympiad health for school children of junior grades].

PMID- 1041939
TI  - [The control over physical education at preschool institutions].

PMID- 1041940
TI  - [Education of the nurse and progress of medicine].

PMID- 1041941
TI  - [Team medical care].

PMID- 1041942
TI  - [The nurse in the interdisciplinary team].

PMID- 1041943
TI  - [Psychiatric nurses in their rehabilitation role].

PMID- 1041944
TI  - [Nurse's role in the rehabilitation of laryngectomized patients].

PMID- 1041945
TI  - [Reception, orientation and integration of new nursing staff in hospitals].

PMID- 1041946
TI  - Nursing does have a future.

PMID- 1041947
TI  - "Where are the nurses?".

PMID- 1041948
TI  - Home deliveries.

PMID- 1041950
TI  - Service-teaching.

PMID- 1041949
TI  - Developing a philosophy of family nursing.

PMID- 1041951
TI  - "A little something called FNS".

PMID- 1041952
TI  - Community medicine rotation.

PMID- 1041953
TI  - Rehumanizing medicine.

PMID- 1041955
TI  - The value of values in nursing education.

PMID- 1041954
TI  - Update on aging: its problems, its promises.

PMID- 1041956
TI  - Writing a nursing term paper.

PMID- 1041957
TI  - Know your generics: "the phenothiazine drugs".

PMID- 1041959
TI  - Community health highlights: Immunization Action Month.

PMID- 1041958
TI  - Legislation affects "Breakthrough" too!

PMID- 1041960
TI  - Self-assessment and career choice.

PMID- 1041961
TI  - Making a career choice: think twice!

PMID- 1041963
TI  - 1975 Convention--rights with responsibility.

PMID- 1041962
TI  - Project tomorrow is now.

PMID- 1041964
TI  - How to protect yourself against malpractice.

PMID- 1041965
TI  - Nursing's past and potential role in alcoholism.

PMID- 1041966
TI  - Breakthrough to Nursing. One down, two to go!

PMID- 1041967
TI  - When bill becomes law, then what? Example: the Nurse Training Act.

PMID- 1041968
TI  - Victims of sexual assault.

PMID- 1041969
TI  - Rape and nursing intervention: locating resources.

PMID- 1041970
TI  - The rape of Sheila Robinson.

PMID- 1041971
TI  - A hospital "maven" speaks her mind.

PMID- 1041972
TI  - Sensation of touch.

PMID- 1041973
TI  - Impressions of non-patients admitted to mental hospitals.

PMID- 1041974
TI  - On their own: nursing students participate in demonstration projects in inner
      city, rural areas.

PMID- 1041976
TI  - [The different categories of errors in care. 3].

PMID- 1041975
TI  - [Individualized care - is it realizable?].

PMID- 1041977
TI  - [Appointment with the EMI scanner].

PMID- 1041978
TI  - [Review of brain tumors].

PMID- 1041979
TI  - [Delivery in Holland].

PMID- 1041980
TI  - [Nursing research: some questions of ethics and rights].

PMID- 1041981
TI  - [Is it necessary to control quality? (2)].

PMID- 1041982
TI  - [The experience of living as an aged].

PMID- 1041983
TI  - Editorial: Risk.

PMID- 1041984
TI  - Cot deaths. I. The relevance of dehydration in some cot deaths.

PMID- 1041985
TI  - Cot deaths. II. Prospective investigation into cot deaths.

PMID- 1041986
TI  - Cot death. III. Leaflet for parents.

PMID- 1041988
TI  - Editorial: The NHS--a maintenance or breakdown service?

PMID- 1041987
TI  - Play material for the first five years. II.

PMID- 1041989
TI  - As others see us.

PMID- 1041990
TI  - Family background and antisocial behaviour.

PMID- 1041991
TI  - Wanderings in paradise.

PMID- 1041992
TI  - Bereavement.

PMID- 1041993
TI  - A look at health education in schools.

PMID- 1041994
TI  - The Childminding Research and Development Unit.

PMID- 1041996
TI  - Community health councils.

PMID- 1041995
TI  - The needs of the smaller child.

PMID- 1041997
TI  - Some thoughts on the lone mother and her child in Messenger House.

PMID- 1041998
TI  - Developing relationships between mother and child. With special reference to
      babies placed in special care units.

PMID- 1041999
TI  - A slimming club in Cyprus.

PMID- 1042000
TI  - Case study: the student.

PMID- 1042001
TI  - The breastfeeding promotion group.

PMID- 1042002
TI  - A psychological study of child battering.

PMID- 1042003
TI  - Editorial: Looking to the future.

PMID- 1042004
TI  - Health visiting in the seventies.

PMID- 1042005
TI  - Staffing of the health visiting and school nursing services.

PMID- 1042006
TI  - Play material for the first five years. 1.

PMID- 1042007
TI  - The unlimited future of critical-care nursing.

PMID- 1042008
TI  - Indications and techniques for ambulatory electrocardiogram monitoring.
AB  - The development of the ability to record a patient's ECG during a full 24-hour
      day of normal activities has resulted in improved arrhythmia detection and
      potential for treatment. Improved methods of ECG data processing, using computer
      techniques, now allows quantitation of PVC frequency and improved correlation of
      the arrhythmia with events occurring during the period of recording. Knowledge of
      the natural occurrence and variability of ambulatory arrhythmias permits
      appropriate choice and timing of antiarrhythmic therapy.

PMID- 1042009
TI  - The role of ambulatory monitoring in postinfarction patients.
AB  - Ventricular premature contractions noted at the time of hospital discharge
      following myocardial infarction identify a population of patients at risk for
      late, sudden cardiac death. Patients with PVC's who are at exceptionally high
      risk can be identified by means of certain clinical and arrhythmic
      characteristics. Late ambulatory monitoring is the most effective single
      technique for identifying such individuals and for monitoring their response to
      anti-arrhythmic medication.

PMID- 1042010
TI  - The role of ambulatory real-time monitoring in ischemic heart disease.
AB  - Pending the long-term solution of the problem of coronary atherosclerosis, and
      considering the unlikelihood of a universally effective, nontoxic, anti
      arrhythmic regimen, it seems likely that ambulatory real-time monitoring is a
      promising avenue of approach for attacking the largest share of IHD mortality,
      namely the 2/3 who currently die before any medical attention.

PMID- 1042011
TI  - Newer techniques in cardiac monitoring.

PMID- 1042012
TI  - Systems approach in assessing behavioral problems of critical-care patients.

PMID- 1042013
TI  - Dyspnea in the patient with cardiopulmonary disease.
AB  - Dyspnea in the patient with cardiopulmonary disease has been defined and
      discussed, emphasizing those conditions which increase the work of breathing:
      increased elastic resistance; increased airway obstruction; and deformities of
      the chest wall, lung, and pleura. Methods of assessing the cardiopulmonary status
      of the patient as it relates to each condition were presented. Determining and
      understanding such clinical signs as patterns of breathing, cough and secretions,
      rales, rhonchi, wheezes, diminished or augmented breath sounds, poor or unequal
      expansion of the rib cage, and dullness or hyperresonance on percusion is
      extremely important for the nurse in order to accurately and comprehensively make
      a nursing assessment. Such an assessment can provide the information necessary to
      plan more effectively for the care of the patient with cardiopulmonary disease.

PMID- 1042014
TI  - Energy metabolism in shock.
AB  - Shock produces a state of low-energy production secondary to lack of oxygen. Only
      1/5 of the energy produced under aerobic conditions can be produced in shock and
      less so if shock continues and loss of nucleotide bases and substrate occurs.
      Carbohydrates and their intermediate compounds are responsible for the energy
      produced during shock. As cellular derangements and loss of energy supplying
      compounds are becoming better understood, their contributions to a condition of
      irreversible shock are receiving more consideration. Studies utilizing energy
      substrates, prevention of nucleotide loss, and supplying high-energy compounds
      have been done and show promise as a therapeutic modality.

PMID- 1042015
TI  - Sinus bradycardia and A-V nodal escape with 2:1 retrograde A-V block.

PMID- 1042016
TI  - Arrhythmias in the coronary-care unit. I. Physiologic bases of ectopic beats.
AB  - Ectopic beats appearing in the wake of an acute myocardial infarction are best
      explained with a fundamental knowledge of myocardial cellular electrophysiology.
      When the physician or nurse has knowledge of the electrical events of
      intracellular recordings then normal as well as abnormal states of automaticity
      and conductivity are better understood.

PMID- 1042017
TI  - Letters: The use of intra-aortic balloon counterpulsation in the management of
      cardiogenic shock.

PMID- 1042018
TI  - American Association of Critical-Care Nurses. President's message.

PMID- 1042019
TI  - The limitations of emergency revascularization surgery.

PMID- 1042020
TI  - Renal disease and critical care.

PMID- 1042021
TI  - Dialysis--current status and future trends.

PMID- 1042022
TI  - Some aspects of the nursing care for patients on hemodialysis.
AB  - Currently the majority of patients receiving hemodialysis for chronic renal
      failure are treated as outpatients in hemodialysis units of large hospitals. In
      most of these units it is the nurses that handle the entire dialysis procedure
      with little if any direct supervision from physicians. The nurses are also the
      ones on the health team that have the most contact with the patients. Thus the
      nurse must have a thorough knowledge of the pathophysiology of renal failure, of
      the mechanics and technical aspects of the dialyzer, of the expected outcomes and
      complications of hemodialysis and, particularly, the needs of the hemodialysis
      patient. The nurses that choose to work with chronic hemodialysis patients can
      enjoy much satisfaction in assisting in maintaining both a productive life and a
      long-term relationship with chronic renal failure patients. The nurse makes the
      difference.

PMID- 1042023
TI  - Nursing implications in prevention of complications in peritoneal dialysis.

PMID- 1042024
TI  - Clinical aspects of renal biopsy.

PMID- 1042025
TI  - The ailing A-V junction.
AB  - The "ailing A-V junction" includes a spectrum of arrhythmias and conduction
      defects owing to abnormalities in impulse formation (junctional rhythms), impulse
      conduction (A-V dissociation), and impulse storage (ventricular pre-excitation).
      A schema is presented for the identification of these dysrhythmias based upon
      modern electrophysiologic concepts. Hopefully, precise electrophysiologic
      diagnosis will yield a rational approach to therapy.

PMID- 1042026
TI  - Electrocardiographic recognition of ventricular ectopic beats in lead V1--a
      preliminary report.

PMID- 1042027
TI  - Pacemaker bigeminy: pseudomalfunction.
AB  - The first reported unique case of atrial synchronized pacemaker-induced bigeminy
      is described and related literature is briefly discussed. The arrhythmia reported
      in this case can be erroneously misinterpreted as a malfunctioning pacemaker
      unless the physician is fully familiar with the specific nature of the atrial
      synchronized pacemaker. By recognizing this type of pacemaker bigeminy as an
      arrhythmia simply related to a normally functioning pacemaker, unnecessary
      surgery can be avoided.

PMID- 1042028
TI  - Vasodilator therapy in acute myocardial infarction.
AB  - In the context of these studies, the evidence indicates that cardiac performance
      can improve significantly during vasodilator therapy in acute MI complicated by
      pump failure. Although the clinical course in uncomplicated patients is good,
      even without active therapeutic interventions, prognosis in patients with pump
      failure treated by standard methods (digitalis and diutetics) is discouraging.
      Hospital mortality approaches "40 per cent in patients with moderately depressed
      cardiac function and may reach as high as 100 per cent in patients with severe
      pump failure and/or cardiogenic shock." The evidence presented suggests that
      early and cautious vasodilator therapy may significantly alter this poor
      prognosis by its beneficial effects on both LV function and the determinants of
      myocardial oxygen consumption.

PMID- 1042029
TI  - Near-drowning.
AB  - It can be seen that the physiologic changes occurring in near-drowning are
      complex. The pulmonary changes including edema, shunting, and alterations in
      surfactant properties cause disturbances in oxygenation and acid-base balance
      which can have severe consequences for the near-drowning victim if immediate and
      intelligent treatment is not directed toward their correction. Although blood
      volume, serum electrolyte, and hematologic changes are generally not severe, they
      must still be considered. The secondary effects, which make up the clinical
      situation met with in patients eventually admitted to the hospital, may result in
      disaster in those who appear to have recovered from the acute episode unless
      careful vigilance is maintained. The possession of a sound knowledge base related
      to these aspects is essential in the treatment and care of near-drowning victims.

PMID- 1042030
TI  - Chest pain.

PMID- 1042031
TI  - Arrhythmias in the coronary-care unit. III. Physiologic bases of paroxysmal
      tachycardia-dependent A-V block.
AB  - This vignette illustrates the application of electrophysiological principles to
      the clinical problems of acute trifascicular A-V block occurring during an acute
      MI. Paroxysmal trifascicular A-V block that occurs transiently during an acute MI
      can be explained electrophysiologically as being due to tachycardia-dependent or
      bradycardia-dependent A-V block or both. Tachycardia-dependent A-V block also
      referred to as phase 3 A-V block is a term used when a premature beat occurring
      during repolarization of the preceeding beat causes conduction failure.
      Bradycardia-dependent A-V block or phase 4 block is used to explain the slowing
      of conduction or block after a longer diastolic interval. Physicians and nurses
      can improve their care of the critically ill cardiac patient through a better
      understanding of pathophysiology.

PMID- 1042032
TI  - Letter: Cardiopulmonary resuscitation.

PMID- 1042033
TI  - [Health begins at home].

PMID- 1042034
TI  - [New ways of organizing hospital units. Their effect on patient care].

PMID- 1042035
TI  - [Psychology of modern women in a therapeutic role].

PMID- 1042036
TI  - [New trends of the nursing establishment; its influence on the care of the sick].

PMID- 1042037
TI  - Urinary 17-ketosteroid and uropepsin excretion in active duodenal ulcer patients.

PMID- 1042038
TI  - Continuing education and nursing service an example of working togetherness.

PMID- 1042040
TI  - ANA National Review Committee. Criteria for selection of members.

PMID- 1042039
TI  - A short-term continuing education program for the development of a pediatric
      oncology nurse.

PMID- 1042041
TI  - Consultation in nursing.

PMID- 1042042
TI  - The mountain goes to Muhammed.

PMID- 1042043
TI  - Space satellite in health education.

PMID- 1042044
TI  - Mandatory continuing education for relicensure in nursing and the implications
      for higher education.

PMID- 1042045
TI  - Traveling teacher.

PMID- 1042046
TI  - An experience in change.

PMID- 1042048
TI  - Personal factors - help or hindrance to continued learning by the nurse.

PMID- 1042047
TI  - Correlates of professional obsolescence: part I.

PMID- 1042049
TI  - Principles for developing inservice educational programs from the nineteen fifty
      sixth yearbook of the National Society for the Study of Education.

PMID- 1042051
TI  - Pharmacology for licensed practical nurses.

PMID- 1042050
TI  - Continuing education? Yes, but how?

PMID- 1042052
TI  - Computed tomography using the EMI scanner: Part I. The apparatus, the normal
      scan, and its variants.

PMID- 1042053
TI  - Computed tomography using the EMI scanner: Part II. Intracranial pathology.

PMID- 1042054
TI  - The therapeutic use of cold.

PMID- 1042055
TI  - Anterior dislocation of the knee joint: report of a case.

PMID- 1042056
TI  - Acute cerebellar ataxia: report of case.

PMID- 1042057
TI  - Cancer of the posterior one-third of the tongue and the floor of the mouth:
      present forms of treatment.

PMID- 1042059
TI  - The professional nurse and the care of the aged.

PMID- 1042058
TI  - Retirement as a nursing concern.

PMID- 1042060
TI  - A survey of incident reports.

PMID- 1042061
TI  - "Contact--may I help you?".

PMID- 1042062
TI  - Editorial: Nursing care for older adults.

PMID- 1042063
TI  - A pilot study in reality orientation for the confused elderly.

PMID- 1042064
TI  - Living environments, geriatric wheelchairs and older persons' rehabilitation.

PMID- 1042065
TI  - Dignified death: a right not a privilege.

PMID- 1042066
TI  - Gerontological nursing is not boring or depressing.

PMID- 1042067
TI  - A happier healthier old age.

PMID- 1042068
TI  - Sexuality in the aged.

PMID- 1042069
TI  - An empirical analysis of the relationship of selected structural factors to
      quality of patient care in nursing homes.

PMID- 1042070
TI  - Creating the new professional.

PMID- 1042071
TI  - Attitudes of the aged toward death and dying: considerations for the
      administrator.

PMID- 1042072
TI  - Planning effective education in the long term care facility.

PMID- 1042073
TI  - The neurosurgical nurse and computer work together.

PMID- 1042074
TI  - Nursing responsibilities in arterial and intracranial pressure monitoring.

PMID- 1042075
TI  - Surgical correction of cranial-facial anomalies.

PMID- 1042076
TI  - Air embolism during surgery in the sitting position: its prevention, detection,
      and treatment.

PMID- 1042077
TI  - Crisis intervention: the patient with interruption of spinal cord integrity.

PMID- 1042078
TI  - The concept of neurosurgical care in a general hospital.

PMID- 1042079
TI  - Transcutaneous electrical stimulation.

PMID- 1042080
TI  - Trigeminal neuralgia: diagnosis and treatment with special reference to
      percutaneous radiofrequency rhizotomy.

PMID- 1042081
TI  - [Euthanasia from the viewpoint of ethics (author's transl)].

PMID- 1042082
TI  - [Coping behavior of the dying patient (author's transl)].

PMID- 1042084
TI  - [Death of a neighbor (author's transl)].

PMID- 1042083
TI  - [The reaction of patient's family to death (author's transl)].

PMID- 1042085
TI  - [Care of the dying patient (author's transl)].

PMID- 1042086
TI  - [Exploration of the identified factors which influence the graduate nurses' care
      of the dying patient (author's transl)].

PMID- 1042087
TI  - [The nurse's perception in ICU (author's transl)].

PMID- 1042088
TI  - [Post-amputation nursing care (author's transl)].

PMID- 1042089
TI  - [Pulmonary artery catheter and it's nursing implication (author's transl)].

PMID- 1042090
TI  - [Nursing care of patients with mechanical cardiac pacemakers (author's transl)].

PMID- 1042091
TI  - [What is it like to be dying (author's transl)].

PMID- 1042092
TI  - [The care of patients within 30 hours after valve-replacement surgery--an
      exploratory study (author's transl)].

PMID- 1042093
TI  - [The relationship between body movement and postoperative vomiting (author's
      transl)].

PMID- 1042094
TI  - [A study of the activities of the head nurse and the clerk in a ward unit
      (author's transl)].

PMID- 1042096
TI  - [Continuing education (author's transl)].

PMID- 1042095
TI  - [An evaluation of self-perineal care of the postpartum (author's transl)].

PMID- 1042098
TI  - [The nursing process].

PMID- 1042097
TI  - [Sensory deprivation (author's transl)].

PMID- 1042099
TI  - [An inherited pathology (author's transl)].

PMID- 1042100
TI  - [On clinical teaching in nursing (author's transl)].

PMID- 1042101
TI  - [A guide to nursing education of United Kingdom (author's transl)].

PMID- 1042102
TI  - [Evaluation of using the concept of "nursing process" in clinical nursing
      (author's transl)].

PMID- 1042103
TI  - [Food craving of pregnant women (author's transl)].

PMID- 1042104
TI  - [Nursing care of radiation oncology (author's transl)].

PMID- 1042105
TI  - [Medical use of sonography--an introduction (author's transl)].

PMID- 1042106
TI  - [The influence of Oedipus complex to the personality development (author's
      transl)].

PMID- 1042107
TI  - [Communicating with patients (author's transl)].

PMID- 1042109
TI  - [Children's mental health center (author's transl)].

PMID- 1042108
TI  - [Taipei City Women's and Children's Hospital (author's transl)].

PMID- 1042110
TI  - [Teaching by concepts (author's transl)].

PMID- 1042111
TI  - The cost of competency.

PMID- 1042112
TI  - P.E.T. (Point Evaluation Tool) a method of evaluating professional nurse
      performance.

PMID- 1042113
TI  - A nurse views credentialing.

PMID- 1042114
TI  - A pilot project in continuing education for critical care nursing.

PMID- 1042115
TI  - Educational administration: managing complexity.

PMID- 1042116
TI  - The nursing administrators growing role in facilities planning.

PMID- 1042117
TI  - Maintaining continuity of care during shift change.

PMID- 1042118
TI  - Reliability study of a nursing flow sheet.

PMID- 1042119
TI  - Continuing education vs. continuing competence.

PMID- 1042120
TI  - A block scheduling system.

PMID- 1042121
TI  - Researchers? Of course!

PMID- 1042122
TI  - ACNM; an organization full of promise.

PMID- 1042123
TI  - Perspectives.

PMID- 1042124
TI  - A preliminary report: severe respiratory distress in transitional newborn lambs
      with recovery following nonnutritive sucking.

PMID- 1042125
TI  - Creative approaches to nurse-midwifery education. I. Mastery learning: an
      approach to individualizing learning.

PMID- 1042126
TI  - Creative approaches to nurse-midwifery education. II. Designing and implementing
      modules: a guide for the educator.

PMID- 1042127
TI  - Creative approaches to nurse-midwifery education. III. Meeting specialized
      problems with creative solutions: an experience with faculty exchange.

PMID- 1042128
TI  - Creative approaches to nurse-midwife education. IV. Video taping: some practical
      guidelines.

PMID- 1042129
TI  - Creative approaches to nurse-midwife education. VI. The use of an educational
      consultant: an approach to curriculum planning.

PMID- 1042130
TI  - Issues in nurse-midwifery education.

PMID- 1042132
TI  - Your aphasic patient; comprehending...communicating.

PMID- 1042131
TI  - Editorial: Heroism in nursing.

PMID- 1042133
TI  - Emergency care: assessment and action. Part III.

PMID- 1042134
TI  - Childhood leukemia: its changing aspects.

PMID- 1042135
TI  - Caring for the child with a tracheostomy.

PMID- 1042136
TI  - Mary: rights of a retarded child.

PMID- 1042137
TI  - The nursing process; how to assess your patient's needs. Part II.

PMID- 1042138
TI  - As a nurse, how can you help?

PMID- 1042139
TI  - Editorial: Accreditation: a credit to higher educational standards.

PMID- 1042140
TI  - Myths about milk.

PMID- 1042141
TI  - Accreditation: the American way.

PMID- 1042143
TI  - Selecting and teaching SP/VNs.

PMID- 1042142
TI  - Sixteen or sixty; does it make a difference?

PMID- 1042144
TI  - The nursing process. Formulation... care plan. Part III.

PMID- 1042145
TI  - Hemorrhoids: how to care when it's simple.

PMID- 1042146
TI  - Issues in caring for blind patients.

PMID- 1042147
TI  - NAPNES; Practical/Vocational Nursing Accreditation Program--1976.

PMID- 1042148
TI  - Educational programs in practical/vocational nursing accredited by NAPNES as of
      November, 1975.

PMID- 1042149
TI  - Good night nurse.. and goodbye.... Part 1.

PMID- 1042150
TI  - The nursing process: implementation and evaluation. Part IV.

PMID- 1042152
TI  - Myasthenia gravis; a time of quiet desperation.

PMID- 1042151
TI  - Urinary tract infection in women. Part I.

PMID- 1042153
TI  - Caring for the hospitalized cerebral palsy patient.

PMID- 1042155
TI  - What are those animals doing on the "health care team?".

PMID- 1042154
TI  - Cries of children.

PMID- 1042156
TI  - Editorial: Innovations in continuing education for '76.

PMID- 1042157
TI  - The first half-hour.

PMID- 1042158
TI  - When prevention fails. Suicide, Part II.

PMID- 1042160
TI  - Nursing in... the nursing home.

PMID- 1042159
TI  - Self-catheterization in urinary tract disease. Part II.

PMID- 1042161
TI  - Reality orientation: restoring the senile to life. Part 1.

PMID- 1042162
TI  - Do unto others... legal lore for the LP/VN.

PMID- 1042163
TI  - Editorial: Accreditation recognition renewed.

PMID- 1042165
TI  - Diet therapy in renal failure.

PMID- 1042164
TI  - End-stage kidney disease current concepts in care. 1.

PMID- 1042166
TI  - . . . But, I'm just like everybody else.

PMID- 1042167
TI  - Reality orientation: restoring the senile to life. 2.

PMID- 1042168
TI  - The slap-stick chart.

PMID- 1042169
TI  - Editorial: Advertising and infant feeding.

PMID- 1042170
TI  - An integrated basis for child health care in the developing countries.

PMID- 1042171
TI  - Aetiological factors in genu valga, vara and varovalga in Nigerian children.

PMID- 1042172
TI  - The role of health survey research in maternal and child health family planning
      programmes: Danfa Project, Ghana.

PMID- 1042173
TI  - Coeliac disease in Iraqi children.

PMID- 1042174
TI  - Congenital hypertrophic pyloric stenosis in Sudanese children.

PMID- 1042175
TI  - Under-fives clinic in Malawi. The development of a national programme.

PMID- 1042176
TI  - Pathological growth and maturation in infants and children associated with modern
      methods of feeding.

PMID- 1042177
TI  - Field indicators of high risk of infant death based on birth information.

PMID- 1042178
TI  - The 2 + 1 programme.

PMID- 1042180
TI  - The practice of nursing.

PMID- 1042179
TI  - Advanced nursing education at the University of the West Indies.

PMID- 1042181
TI  - Evaluation in nursing education.

PMID- 1042182
TI  - Democratic education - its implications for nursing education.

PMID- 1042183
TI  - [Changes of antimicrobial susceptibility of anaerobic bacteria from clinical
      specimens (author's transl)].
AB  - The susceptibility to several commonly used antimicrobial agents was examined on
      approximately 900 isolates of various anaerobes from clinical specimens between
      October 1965 to May 1975, and the changes of susceptibility were investigated.
      Antimicrobial agents tested were penicillin G (PC-G), ampicillin (AB-PC),
      cephaloridine (CER), erythromycin (EM), josamycin (JM), lincomycin (LCM),
      clindamycin (CLDM), chloramphenicol (CP) and tetracycline (TC). And thiamphenicol
      (TP) and doxycycline (DOTC) were also used against recently isolated organisms.
      Minimal inhibitory concentrations (MIC) were determined with agar plate dilution
      method. The activity of PC-G, AB-PC and CER against almost all strains of
      anaerobes was good at 12.5 mug/ml or less, but a marked increase of resistant
      strains of Bacteroides was recognized. EM, JM and LCM had similar activity
      against anaerobes, and were effective to most strains of anaerobes except for
      Veillonella, Bacteroides and Fusobacterium. CLDM was highly active against almost
      all strains of anaerobes, and more active than the two macrolides and LCM. But
      recently, significant increase in resistant strains was observed among
      Bacteroides. CP had good activity against all strains of anaerobes, and the
      increase of resistant strains was not recognized. TP had a similar good activity
      as CP. While, activity of TC against all anaerobes was poor at the level of 25
      mug/ml or more. DOTC was more active than TC against all strains tested.

PMID- 1042185
TI  - [Importance of communication, recording and statistics in midwifery practice].

PMID- 1042184
TI  - [Current maternal and child welfare systems in Europe. Discussion].

PMID- 1042186
TI  - [Legal disputes concerning obstetrical nursing].

PMID- 1042187
TI  - [Psychology of the patients facing fetal death or perinatal death and management
      of the difficult situation. Questionnaires from patients, physicians and nurses].

PMID- 1042188
TI  - [Re-evaluation of time involved in delivery].

PMID- 1042189
TI  - [Evaluation of time involved in abnormal delivery].

PMID- 1042191
TI  - [A visit with a practicing midwife. 8. Mrs. Haruko Hashimoto of Mitaka-shi,
      Tokyo].

PMID- 1042190
TI  - [Management and nursing care at the time of membrane rupture. Checkpoints for
      patients admitted with premature rupture of the membrane].

PMID- 1042193
TI  - [Midwifery education in England. An interview with Miss Base, Secretary of the
      ICM (International Council of Midwifery)].

PMID- 1042192
TI  - [Discussion: Regional maternal and child health services and the role of health
      education of expectant mothers].

PMID- 1042194
TI  - [Case report. Case of pregnancy toxemia associated with cerebral hemorrhage].

PMID- 1042195
TI  - [Case of pregnancy toxemia with cerebral hemorrhage. Physician's report].

PMID- 1042196
TI  - [Case conference. Case of pregnancy with cerebral hemorrhage. The patient,
      cognition disorder, and the patient care team].

PMID- 1042197
TI  - [Relationship between salicylic acid concentration and detachment of the
      umbilical cord].

PMID- 1042198
TI  - [Malpractice in obstetrics. 1. Introduction].

PMID- 1042199
TI  - [Expectant patients and hematological tests].

PMID- 1042200
TI  - [Maternal and child health care in Laos].

PMID- 1042201
TI  - [Case report: pregnancy complicated by chronic nephritis].

PMID- 1042202
TI  - [Comment on the case report "pregnancy complicated by chronic nephritis" -
      handling of the patient in informing about the infant's death].

PMID- 1042203
TI  - [Case conference: a pregnant patient with chronic nephritis and her desire to
      deliver a child].

PMID- 1042204
TI  - [Case of puerperal eclampsia].

PMID- 1042205
TI  - [Case of pelvic presentation with the umbilical cord circling the fetal neck 6
      times].

PMID- 1042206
TI  - [Sasebo Obstetric Clinic run by midwives; an interview with chairperson Tokiwa
      Shinbo].

PMID- 1042207
TI  - [Iatrogenic incidents in obstetrics. 2. Accidental fall of the patient].

PMID- 1042208
TI  - [Postnatal development of congenital hip dislocation and its prevention].

PMID- 1042209
TI  - [Chronic nephritis, pregnancy and delivery].

PMID- 1042210
TI  - [Maternal and child care in Laos].

PMID- 1042211
TI  - [Discussion: Instruction in infant care and continuity of nursing].

PMID- 1042212
TI  - [Patient care programs during delivery practiced at our hospital - programs for
      improved cooperation by physicians and nurses. 1].

PMID- 1042213
TI  - [Pregnancy toxemia resulting in intrauterine fetal death - case presentation and
      personal observation].

PMID- 1042214
TI  - [Delivery and puerperal stage of a patient with a past history of heart surgery:
      a case study].

PMID- 1042216
TI  - [Pregnancy and idiopathic thrombocytopenic purpura].

PMID- 1042215
TI  - [Iatrogenic incidents in obsteterics. 3. Burns (1)].

PMID- 1042217
TI  - [Maternal and child care in Vietnam].

PMID- 1042218
TI  - [Definition of midwifery].

PMID- 1042219
TI  - [Personal plan for instruction on research activities by students of midwifery
      schools].

PMID- 1042220
TI  - [Curriculum and examples of on-the-job training--a trial in the first year of the
      midwifery course].

PMID- 1042222
TI  - [Comments on the report on delivery following maternal brain death: problems in
      obstetrical emergencies and their management].

PMID- 1042221
TI  - [Midwifery actions in vaginal delivery following maternal brain death. A case
      report].

PMID- 1042223
TI  - [Case conferences: sudden death of the mother during delivery and problems
      concerning obstetrical emergencies].

PMID- 1042224
TI  - [Childbirth and the teeth].

PMID- 1042225
TI  - [Thermal burns (2)].

PMID- 1042226
TI  - [Fetal distress and changes in the fetal heart rate].

PMID- 1042228
TI  - [Case report. Pregnancy with quadruplets].

PMID- 1042227
TI  - [Aged primigravida and health instructions].

PMID- 1042229
TI  - [Comment on the case report on pregnancy with quadruplets. Etiology of female
      sterility and its treatment].

PMID- 1042230
TI  - [Case conference. Sterility, multiple pregnancy and the first pregnancy in
      relatively older women].

PMID- 1042232
TI  - [A visit with a practicing midwife. 7. Miss Yashi Kikuchi of Kikuchi Clinic at
      Fukaya-shi].

PMID- 1042231
TI  - [Practice of obstetrical care at our hospital--coordination of activities of
      physicians and midwives. 2].

PMID- 1042233
TI  - [Ultrasonic tomography].

PMID- 1042234
TI  - [Iatrogenic incidents in obstetrics. 5. Errors in identification. (1)].

PMID- 1042235
TI  - [Family planning practiced in Southeastern Asia].

PMID- 1042237
TI  - [Organisms and radiation - effects of radiation on the genetic mechanism].

PMID- 1042236
TI  - [Fetal distress and turbidity of the amniotic fluid].

PMID- 1042238
TI  - [Basis of child-rearing. A study based on developmental psychology. 1].

PMID- 1042239
TI  - [Treatment and nursing of infants with congenital heart defects].

PMID- 1042240
TI  - [Evaluation of clinical training - on comprehensive nursing theory].

PMID- 1042242
TI  - [Various problems concerning radiotherapy - on radiation protection and hospital
      administration].

PMID- 1042241
TI  - [Indication and adverse effects of radiotherapy in the treatment of cancer].

PMID- 1042243
TI  - [Nursing duty and nursing administration concerning radiotherapy - with special
      reference to the current practice of nursing].

PMID- 1042244
TI  - [Radiotherapy of brain tumors and nursing of patients with psychological stress].

PMID- 1042245
TI  - [Methods of radiotherapy in the treatment of tongue cancer and nursing care
      associated with the therapy].

PMID- 1042246
TI  - [Application of radiotherapy in laryngeal cancer and associated nursing care].

PMID- 1042247
TI  - [Radiotherapy of cervical cancer and nursing activities during the routine
      therapeutic course].

PMID- 1042248
TI  - [Problems concerning radiotherapy of cancer in children and nursing of young
      patients with neuroblastoma].

PMID- 1042249
TI  - [Significance of radiotherapy in the treatment of cancer - with special reference
      to its biological actions].

PMID- 1042250
TI  - [Record of a family who have experienced the death of a young child with
      leukemia].

PMID- 1042251
TI  - [Guilt complex of terminal patients].

PMID- 1042252
TI  - [Sequelae of exposure to the atomic bomb and leukemia].

PMID- 1042253
TI  - [Basis of child-rearing - a study based on developmental psychology. 2].

PMID- 1042254
TI  - [Care of infants following heart surgery].

PMID- 1042255
TI  - [Evaluation of clinical training - on adult nursing].

PMID- 1042257
TI  - [Nursing action in the care of children with acute leukemia - anguish in
      observing a suffering child and an unsolved problem in nursing].

PMID- 1042256
TI  - [Leukemia and infection - pathophysiology and management].

PMID- 1042258
TI  - [Instructions on daily acitivites of a leukemia patient in the isolator. Nursing
      assistance of the patient with mental distress].

PMID- 1042259
TI  - [Instruction on daily activities of acute leukemia patient with repeated
      hospitalization].

PMID- 1042260
TI  - [Instruction for the family of an adult leukemia patient: a case study].

PMID- 1042261
TI  - [Clinical course of leukemia complicated with pneumonia in a child, and
      considerations on the keypoints in nursing].

PMID- 1042262
TI  - [Case of peri-anal abscess developing during remission of leukemia].

PMID- 1042263
TI  - [Clinical description of leukemia - classification, diagnosis and therapy].

PMID- 1042264
TI  - [Limitation in the care of leukemia patients - roles of the physician and the
      nurse].

PMID- 1042265
TI  - [Observations and the diagnostic standard of hematuria].

PMID- 1042266
TI  - [Women and hemorrhage - menstruation and the etiological mechanism and clinical
      characteristics of anemia].

PMID- 1042267
TI  - [Nature of child-rearing - analysis based on theories of child psychology. 3 ].

PMID- 1042268
TI  - [Diseases in the field of neurosurgery and nursing care].

PMID- 1042269
TI  - [Evaluation of instructions on clinical nursing - teaching of pediatric nursing].

PMID- 1042271
TI  - [Hemorrhage and shock - consequences of hemorrhage and their management].

PMID- 1042270
TI  - [Hemorrhage and its treatment - emergency treatment of hemorrhage and blood
      transfusion].

PMID- 1042272
TI  - [Nursing of hemorrhaging patients: observations and nursing care].

PMID- 1042273
TI  - [Surgery and hemorrhage - blood transfusion and fluid infusion before, after and
      during surgery].

PMID- 1042274
TI  - [Hematemesis - its pathophysiology and treatment].

PMID- 1042275
TI  - [Etiology and treatment of epistaxis].

PMID- 1042276
TI  - [Intra-operative hemorrhage and its nursing care: case studies].

PMID- 1042277
TI  - [Pathophysiology of hemorrhage and the mechanism of hemostasis].

PMID- 1042278
TI  - [Nursing of a patient with refractory tuberculosis and recurrent hematemesis].

PMID- 1042279
TI  - [Nursing and observation of cases of hemoperitoneum].

PMID- 1042280
TI  - [Practice of nursing of breast cancer patients and its evaluation].

PMID- 1042281
TI  - [Observations on psychological changes of breast cancer patients - a study based
      on interviews].

PMID- 1042282
TI  - [Mass screening of breast cancer].

PMID- 1042283
TI  - [Increase in the incidence of breast cancer and epidemiological considerations on
      related factors].

PMID- 1042284
TI  - [Nature of child-rearing - analysis based on child psychology. 4].

PMID- 1042285
TI  - [Therapy of malignant tumors in children and its keypoints].

PMID- 1042286
TI  - [Evaluation of training programs for clinical nursing - on obstetrical nursing].

PMID- 1042287
TI  - [Endocrine gland ablation and hormone administration in the treatment of breast
      cancer and their clinical effects].

PMID- 1042288
TI  - [Postoperative complications in breast cancer - their physiopathology and
      management].

PMID- 1042289
TI  - [Group work for breast cancer patients at the Konan Hospital. 1. Rehabilitation
      of patients with breast cancer].

PMID- 1042290
TI  - [Group work for breast cancer patients at the Konan hospital. 2. Rehabilitation
      programs and development of nursing actions for patients with breast cancer].

PMID- 1042291
TI  - [Group work for breast cancer patients at the Konan Hospital. 3. Actions by
      social workers].

PMID- 1042292
TI  - [Group work for breast cancer patients at the Konan Hospital. 4. Volunteers' work
      for assistance of breast cancer patients in social rehabilitation].

PMID- 1042293
TI  - [Orientation and practice of physical training of breast cancer patients].

PMID- 1042294
TI  - [Breast cancer in the surgical field: diagnosis and therapy].

PMID- 1042295
TI  - [Evaluation of methods of applying bandages on extensive burns].

PMID- 1042296
TI  - [Nursing of patients with acute muco-cutaneous lymph node syndrome (Kawasaki's
      disease)].

PMID- 1042297
TI  - [Study on determination of the specific gravity in urinalysis].

PMID- 1042299
TI  - [Radiotherapy of malignant skin cancer].

PMID- 1042298
TI  - [Nursing of a child with psychogenic vomiting].

PMID- 1042300
TI  - [Nature of child-rearing--analysis based on child psychology. 5].

PMID- 1042301
TI  - [Developmental process of pediatric surgery as a specialty and its future
      problems].

PMID- 1042303
TI  - [Surgery of hemorrhoids - various types of hemorrhoids and their postoperative
      care].

PMID- 1042302
TI  - [Evaluation of teaching in clinical training - on nursing research].

PMID- 1042304
TI  - [Hemorrhoids in children - their characteristics and therapeutic policies].

PMID- 1042305
TI  - [Nursing and instructions on daily activities of patients with hemorrhoids -
      evaluation of surgical cases].

PMID- 1042306
TI  - [Instructions on daily activities of patients with hemorrhoids in the outpatient
      clinic].

PMID- 1042307
TI  - [Instructions on daily activities of hemorrhoid patients with special reference
      to sitz bath].

PMID- 1042308
TI  - [Hemorrhoids and their prevention - with special reference to personal hygiene].

PMID- 1042309
TI  - [Diarrhea and constipation - their relationship to more serious diseases].

PMID- 1042310
TI  - [Hemorrhoids - its physiopathology and diagnosis].

PMID- 1042311
TI  - [On discomfort following cystoscopy].

PMID- 1042312
TI  - [Keypoints in administration of oral antidiabetics - with special reference to
      their adverse effects].

PMID- 1042314
TI  - [Statistical observation on diabetes mellitus in Japan].

PMID- 1042313
TI  - [Diabetes mellitus and pregnancy - problems of diabetes during the perinatal
      stage of pregnancy].

PMID- 1042315
TI  - [Genetic transmission of diabetes mellitus - on its etiological mechanism].

PMID- 1042316
TI  - [Surgical diseases of infants and nursing care].

PMID- 1042317
TI  - [Renovation of the system of nursing education].

PMID- 1042319
TI  - [Clinical description of diabetic arteriosclerosis and evaluation of cases].

PMID- 1042318
TI  - [Evaluation of teaching of clinical training - on the teaching plan].

PMID- 1042320
TI  - [Clinical description of diabetic nephropathy and nursing care].

PMID- 1042321
TI  - [Management and nursing of patients with diabetic neuropathies].

PMID- 1042322
TI  - [Clinical management and nursing in cases of diabetes mellitus with ocular
      complications].

PMID- 1042323
TI  - [Various infections associated with diabetes mellitus and nursing care].

PMID- 1042324
TI  - [Dermatological lesions observed in diabetic patients and health care
      instructions].

PMID- 1042326
TI  - [Diabetes mellitus and the significance of complications during its clinical
      course].

PMID- 1042325
TI  - [Diabetes mellitus in young children and the control program--a case study].

PMID- 1042327
TI  - [Diet therapy in diabetes mellitus - on its modern concept].

PMID- 1042328
TI  - [Opening of Kanagawa Prefectural Nursing College: its significance and
      management].

PMID- 1042329
TI  - [Study of problems confronting nursing students through a survey on their
      attitudes to life].

PMID- 1042330
TI  - [Development of a method of teaching the comprehensive theory of nursing. A
      method of teaching nursing technic related to patients' meals in the basic
      nursing course].

PMID- 1042332
TI  - [Working draft (American Nurses' Association. Commission on Nursing Education)].

PMID- 1042331
TI  - [Method of instruction in case studies and its evaluation in junior nursing
      schools].

PMID- 1042333
TI  - [Nursing as an academic entity. VII. Its relationship to drugs and pharmacology].

PMID- 1042334
TI  - [Study plans (planning and formulation)].

PMID- 1042335
TI  - [Experiences of a nursing instructor].

PMID- 1042336
TI  - [Discussion: Nursing in the ICU and its training].

PMID- 1042337
TI  - [Nursing as an independent academic entity. VIII. Nursing and theories of diet
      and nutrition].

PMID- 1042338
TI  - [Educational evaluation in social education].

PMID- 1042339
TI  - [A new trial of training in clinical nursing. V. Comprehesive nursing training-
      nursing of adults. 3. Clinical training in psychiatric nursing].

PMID- 1042340
TI  - [Decision making by the nurse and its training].

PMID- 1042341
TI  - [Future plans for nursing training].

PMID- 1042342
TI  - [Formulation of teaching plan in nursing of adults. A teaching plan in the
      classroom and clinical training in nursing of patients with respiratory tract
      diseases].

PMID- 1042343
TI  - [Coming of age of a refresher program].

PMID- 1042344
TI  - [Nursing as an academic entity. IX. Standard of values in science].

PMID- 1042345
TI  - [Implementation of teaching plans. I. Study of teaching materials].

PMID- 1042346
TI  - [New trial in clinical training of nursing. V. Comprehensive nursing training-
      clinical training in obstetrics].

PMID- 1042347
TI  - [Nursing described in literature. "Doro Ningyo" by Ineko Sata].

PMID- 1042348
TI  - [Nursing education and establishment of the nursing profession as a specialty].

PMID- 1042349
TI  - [Discussion: Impression on the seminar for nursing instructors].

PMID- 1042350
TI  - [A position paper by the ANA Comittee on Education].

PMID- 1042351
TI  - [Educational methodology. Method and format in social education. Learning
      activities of citizens and their promotion].

PMID- 1042352
TI  - [Trial in clinical training in nursing. V. Comprehensive training in adult
      nursing. 1. Clinical training in the field of internal medicine].

PMID- 1042354
TI  - [Environmental health and public health nursing. Environmental problems and
      public health nursing. 1].

PMID- 1042353
TI  - [Further persistence in the professional attitude desired in public health
      nursing--opinion of public health physicians. A discussion].

PMID- 1042355
TI  - [A trial in training in public health nursing with emphasis on field work. (2).
      Report of a field project. I].

PMID- 1042356
TI  - [Analysis of current labor problems concerning nursing (2). II. Various problems
      concerning nurses' lives (health, marriage and child rearing)].

PMID- 1042357
TI  - [Survey of the attitudes of participants of the health education sessions for
      expectant mothers].

PMID- 1042358
TI  - [Activities of "Mutsumi-kai" (an organization for parents of pre-school children
      organized by a local public health clinic in Kanagawa Pref.) in the last 7
      years].

PMID- 1042359
TI  - [Prevention of abnormal pregnancy and the effect of on-the-job health education
      by the industrial health nurse].

PMID- 1042360
TI  - [Public health nursing activities in the management of adult diseases in Shikaya
      Shi].

PMID- 1042361
TI  - [Public health nursing activities at Eigenji-Cho. Management of parasitic
      diseases].

PMID- 1042362
TI  - [Discussion: Clinical nurse with public health nursing background. Significance
      of public health nursing education].

PMID- 1042363
TI  - [Home nursing system of the Tokyo Hakujuji Hospital. Rotation of nurses in
      clinical nursing and the visiting nursing service].

PMID- 1042365
TI  - [Theory of health (5)].

PMID- 1042364
TI  - [Organization of a group of patients with Behcet's disease. Development of
      campaign to assist patients with Behcet's disease and refractory diseases. An
      interview with Mr. Masaomi Fukuyama].

PMID- 1042366
TI  - [Survey on the attitude to sex among youths. (2)].

PMID- 1042367
TI  - [Redefinition of nursing action. 7. Study based on a case erroneously diagnosed
      as encephalomalacia and left unattended for 4 months. (4)].

PMID- 1042368
TI  - [Organization of a group of patients with Behcet's disease. Importance of the
      organization in giving patients hope].

PMID- 1042369
TI  - [Prevention of cerebral apoplexy and public health nursing activities in a
      sparsely populated area].

PMID- 1042370
TI  - [Nursing of a child suspected to be autistic: a case study].

PMID- 1042371
TI  - [Estimation of extent of geriatric nursing needed in a heavily air-polluted
      area].

PMID- 1042372
TI  - [Occurrence of anemia among pregnant women following examination at the public
      health clinic].

PMID- 1042373
TI  - [Uniform for the public health nurse with individual choice in its use].

PMID- 1042375
TI  - [Use of the public health nurse's uniform according to the need of the occasion].

PMID- 1042374
TI  - [Uniform for the public health nurse and its effect on interaction with the
      public].

PMID- 1042376
TI  - [Casual uniform for the public health nurse with a friendly image of the
      profession].

PMID- 1042377
TI  - [On the uniform for the public health nurse; Discussion].

PMID- 1042378
TI  - [Analysis of the current labor problems involving nursing. (1) I. The current
      labor conditions in nursing and their problems].

PMID- 1042379
TI  - [A trial in training in public health nursing with emphasis on field work. (1).
      Approach to the field study].

PMID- 1042380
TI  - [Survey on the attitudes of married working women and the management toward
      maternal welfare legislation].

PMID- 1042381
TI  - Rock and 'bye, Baby.

PMID- 1042382
TI  - Toward better preparation for involved fatherhood.

PMID- 1042383
TI  - Prepared childbirth and the concept of control.

PMID- 1042384
TI  - Examinee strategies for increasing test scores.

PMID- 1042385
TI  - Uterine contractile physiology: applications in nursing care and patient
      teaching.

PMID- 1042386
TI  - The cooperative roles of the physician and nurse in obstetric practice.

PMID- 1042387
TI  - [Psychosomatic viewpoints on pregnancy and delivery].

PMID- 1042388
TI  - [Genetic counseling in nursing - ethics and psychological aspects].

PMID- 1042390
TI  - [The "First Homes" start a campaign for breast feeding].

PMID- 1042389
TI  - [Current dietetic recommendations for newborn infants].

PMID- 1042391
TI  - [Editorial: Statement of the Federation of Midwives on the 5-year plan for
      national health services].

PMID- 1042392
TI  - [Methods of estimating the age of the fetus].

PMID- 1042393
TI  - [The mentally retarded].

PMID- 1042394
TI  - [Midwife's functions during labor and delivery].

PMID- 1042395
TI  - [Hypocalcemia in newborn infants].

PMID- 1042396
TI  - [Illegitimate children and the Child Welfare officer].

PMID- 1042397
TI  - [Greetings from a rooming-in hospital in Kenya].

PMID- 1042398
TI  - [The future of maternity care causes deep concern].

PMID- 1042399
TI  - [The placing of specialized state-registered nurse-midwives on the labor market].

PMID- 1042400
TI  - [The use of a safety belt during pregnancy].

PMID- 1042401
TI  - [Discussion: on aged patients; their status and their satisfaction with life].

PMID- 1042402
TI  - [Current status of welfare legislation for the aged and its problems; need for a
      more positive national policy for assistance of the aged].

PMID- 1042404
TI  - [Nursing seminar: Pediatric nursing, questions and answers].

PMID- 1042403
TI  - [Nursing seminar: Pediatric nursing].

PMID- 1042405
TI  - [Japanese economy and natural resources. I. The theory of continuous population
      and exhaustible material supply].

PMID- 1042406
TI  - [On the degree-awarding nursing course. Discussion by the students currently in
      school. II. Economic problems facing the prospective students].

PMID- 1042407
TI  - [Life style of the Japanese and the position of nursing--need for more scientific
      consideration].

PMID- 1042408
TI  - [Improvement of medical records for better medical practice].

PMID- 1042409
TI  - [Discussion: On working conditions for nurses].

PMID- 1042410
TI  - [Assistance of the patient in his daily activities--the role of nursing].

PMID- 1042411
TI  - [Diet for the nurse and nursing duty].

PMID- 1042412
TI  - [Japanese economy and natural resources. II. Food supply in Japan].

PMID- 1042413
TI  - [On the degree-awarding nursing course. Discussion by the students currently in
      school. III. Changes in the attitudes of students].

PMID- 1042414
TI  - [Patients' expectations of nursing].

PMID- 1042415
TI  - [Nursing seminar. Pharmacology].

PMID- 1042417
TI  - [Difficulty in understanding the patient's feelings: importance of accurate
      understanding of patient's needs].

PMID- 1042416
TI  - [Nursing seminar. Microbiology].

PMID- 1042418
TI  - [Degree granting course in nursing. Humane nursing as a goal of the profession].

PMID- 1042419
TI  - [Nursing report. Nursing of a patient with neck sprain].

PMID- 1042420
TI  - [A thought on modern medicine: on philosophy of medicine].

PMID- 1042421
TI  - [Nursing based on the needs of the patient: a note from a social worker].

PMID- 1042422
TI  - [Role of nursing and inconsistency in medical systems].

PMID- 1042423
TI  - [Nursing seminar. Internal medicine and nursing].

PMID- 1042424
TI  - [Questions and answers in nursing. Internal medicine].

PMID- 1042425
TI  - [Increase in the aged population in Japan].

PMID- 1042426
TI  - [Degree-granting course in nursing. Discussion by students in the degree-granting
      nursing course. 1. More dependable nursing as a goal of the study].

PMID- 1042428
TI  - The effect of transcendental meditation upon modifying the cigarette smoking
      habit.

PMID- 1042427
TI  - [Nursing report. Nursing of a patient with pulmonary tuberculosis and diabetes
      mellitus].

PMID- 1042429
TI  - How to plan and present a school-community health fair.

PMID- 1042430
TI  - School health service needs in Wisconsin.

PMID- 1042431
TI  - Rethinking an ecologic-system model of man's health, disease, aging, death.

PMID- 1042432
TI  - Sex -- role stereotyping in elementary school health education textbooks.

PMID- 1042434
TI  - Safety and accidents -- a brief conceptual analysis, and a point of view.

PMID- 1042433
TI  - The physiological effects of inhaling exhaled cigarette smoke in relation to
      attitude of the nonsmoker.
AB  - Fifty-six nonsmoking college students were exposed, in a closed environment, for
      a period of 20 minutes to the exhaled cigarette smoke of two smokers. After
      intervals of 5, 10, 15 and 20 minutes of being exposed to the exhaled smoke,
      heart rates and systolic and diastolic blood pressures were monitored.
      Differences between times on systolic pressure was the only statistically
      significant finding. The subjects were then divided into two distinct attitude
      groups: (1) those who objected ("disliked") to being in the presence of cigarette
      smoke, and (2) those who did not mind ("indifferent") being in the presence of
      cigarette smoke. Variances attributable to between groups was statistically
      significantly different for heart rate. The "dislike" group had the higher rate
      in comparison to the "indifferent" group. Between times was statistically
      different for both groups for systolic pressure. Between group systolic pressures
      were not significantly different. As expected, there was no significant finding
      concerning diastolic changes.

PMID- 1042435
TI  - The training of adolescent health service personnel.

PMID- 1042436
TI  - Inherited and noninherited anemia screening: a program of community cooperation.

PMID- 1042437
TI  - Life education: a new concept in health education instruction.

PMID- 1042438
TI  - Special contribution: national survey of marijuana use and attitudes.

PMID- 1042439
TI  - Levels of conciousness indicated by responses of children to phenomena in the
      intensive care unit.

PMID- 1042441
TI  - Nurse practitioner as medical assistant.

PMID- 1042440
TI  - Public hospital nurses (state) award.

PMID- 1042442
TI  - Public hospital nurses (state) award.

PMID- 1042443
TI  - Recent emphasis on an "old" discipline--community health education needs.

PMID- 1042444
TI  - The New South Wales College of Nursing Annual Conference on National Nursing
      Issues.

PMID- 1042445
TI  - A white man tries.

PMID- 1042446
TI  - My Papua New Guinea experiences: in retrospect.

PMID- 1042447
TI  - Understanding ward pharmacy.

PMID- 1042448
TI  - Nursing--a quiet revolution or new approach to nursing education.

PMID- 1042449
TI  - [Radiation reactions and complications; their prevention and treatment].

PMID- 1042450
TI  - [Angiography and lymphography in the diagnosis of tumors of the abdominal organs
      and retroperitoneal space].

PMID- 1042451
TI  - [Prevention of injuries in the engine depot].

PMID- 1042452
TI  - [Radioisotope diagnosis in the clinical aspects of internal diseases].

PMID- 1042453
TI  - [The nurse and SLO (Scientific Labor Organization)].

PMID- 1042455
TI  - [Recording of the use of deficient medicines in the hospital].

PMID- 1042454
TI  - [A journal for recording notes on storage, registration and expenditures of
      medicines in various departments].

PMID- 1042456
TI  - [Special armchairs].

PMID- 1042457
TI  - [Radiation therapy].

PMID- 1042458
TI  - [Progressive myopia].

PMID- 1042459
TI  - [Late diagnosis of various eye diseases].

PMID- 1042460
TI  - [Demodex infection].

PMID- 1042461
TI  - [Methods and technic of classic massage in chronic pneumonia].

PMID- 1042462
TI  - [Broncholitics in the combination therapy of patients with pulmonary
      tuberculosis].

PMID- 1042463
TI  - [The therapeutic use of magnetic fields].

PMID- 1042465
TI  - [Diabetes mellitus and its sequelae].

PMID- 1042464
TI  - [Gonorrhea in men].

PMID- 1042466
TI  - [Organization of activities in the room for eye diseases in the polyclinic].

PMID- 1042467
TI  - [Reflect segment massage in diseases of the peripheral blood vessels].

PMID- 1042468
TI  - [Care of the facial skin].

PMID- 1042469
TI  - [Role of the school nurse in the prevention of diseases in girls].

PMID- 1042470
TI  - [Medical gymnastics performed to restore proper posture].

PMID- 1042471
TI  - [A casette for storing ampules with medicinal preparations].

PMID- 1042472
TI  - [Popularization of health knowledge of parents].

PMID- 1042474
TI  - [Various problems concerning organization of activities of auxiliary staff].

PMID- 1042473
TI  - [Experience in the functions of a pharmaceutic station].

PMID- 1042475
TI  - [Paramedical personnel in the public health system of the German Democratic
      Republic].

PMID- 1042476
TI  - [Agranulocytosis caused by medicines].

PMID- 1042477
TI  - [Epileptic disease].

PMID- 1042478
TI  - [Vegeto-vascular disorders in discogenic lumbosacral radiculitis].

PMID- 1042480
TI  - [Mental disturbances in vascular diseases of the brain].

PMID- 1042479
TI  - [Changes of the nervous system in anaphylactic shock developing in response to
      the administration of drugs].

PMID- 1042481
TI  - [Current methods in treatment of parkinsonism].

PMID- 1042482
TI  - [Neuropathy].

PMID- 1042483
TI  - [Socioeconomic factors and health of the population].

PMID- 1042484
TI  - [Hysterical neuroses].

PMID- 1042485
TI  - [A syndrome of psychomotor excitation in acute pneumonia].

PMID- 1042486
TI  - [Acute renal insufficiency and changes of the nervous system].

PMID- 1042487
TI  - [Sex disorders in men].

PMID- 1042488
TI  - [Iatrogenic disease].

PMID- 1042490
TI  - [Massage in spastic paralysis].

PMID- 1042489
TI  - [Experience in organization of functions of a narcological nurse].

PMID- 1042491
TI  - [Role and special features of massage in combination therapy of patients with
      juvenile cerebral palsy].

PMID- 1042492
TI  - [Special features of anesthesia in operations of the hypophysio-hypothalamic
      region].

PMID- 1042494
TI  - Editorial: Acceptable and unacceptable choices.

PMID- 1042493
TI  - [Early postoperative period following removal of tumors of the chiasmo
      diencephalic area].

PMID- 1042495
TI  - He's your client, but he's my patient: a symposium on attitudes toward the
      commitment of mental patients.

PMID- 1042496
TI  - Humanizing institutional care for the aged.

PMID- 1042497
TI  - Clinical experience for students redefined.

PMID- 1042498
TI  - Court procedures in child abuse.

PMID- 1042499
TI  - Therapeutic abortion and its aftermath.

PMID- 1042500
TI  - Breast feeding. A trilogy. Part 1. The physiologist's tale.

PMID- 1042501
TI  - The present status of ascorbic acid.

PMID- 1042502
TI  - Breast feeding--a trilogy. Part 2. The psychologist's tale.

PMID- 1042503
TI  - Counselling for abortion.

PMID- 1042504
TI  - Sharing and caring.

PMID- 1042506
TI  - Editorial: The birth rate.

PMID- 1042505
TI  - Epidural analgesia in practice.

PMID- 1042507
TI  - Effects of stress on the modern adolescent.

PMID- 1042508
TI  - Breast feeding--a trilogy. Part 3. The sociologist's tale.

PMID- 1042509
TI  - Getting it off my chest.

PMID- 1042510
TI  - Haematinic preparations.

PMID- 1042511
TI  - Antenatal education.

PMID- 1042512
TI  - Social factors and feeding practices in hypernatraemia.

PMID- 1042513
TI  - Complications in treatment of epilepsy.

PMID- 1042514
TI  - Contamination of infant feeds in hospitals.

PMID- 1042515
TI  - Editorial: Obstetric audit.

PMID- 1042516
TI  - Modern antenatal care--an appraisal. Part 1.

PMID- 1042517
TI  - The concept of psychology in midwifery.

PMID- 1042518
TI  - "We are different".

PMID- 1042519
TI  - Programmed instruction.

PMID- 1042520
TI  - Case study: hydatidiform mole.

PMID- 1042521
TI  - Some hazards of anaesthesia for obstetrics.

PMID- 1042522
TI  - Recent advances in teaching methods.

PMID- 1042524
TI  - A brief look at SI units.

PMID- 1042523
TI  - Epidural analgesia in obstetrics.

PMID- 1042525
TI  - Why breast feeding is good for mother and baby.

PMID- 1042526
TI  - Crisis in the national health service?

PMID- 1042527
TI  - Changes in infections in midwifery since the 1930s.

PMID- 1042529
TI  - "Ambition, distraction, uglification and derision".

PMID- 1042528
TI  - A Danish teaching scheme.

PMID- 1042530
TI  - [Opening of the symposium on carcinogenic hazards in the environment].

PMID- 1042531
TI  - [Employment and job and living conditions of nursing personnel].

PMID- 1042532
TI  - [Acupuncture analgesia in surgical obstetrics in Alexandria].

PMID- 1042533
TI  - Diary of a WHO fellow.

PMID- 1042534
TI  - "Code 66!" From anxious "amateurs" to smooth-working code team.

PMID- 1042535
TI  - Cancer chemotherapy.

PMID- 1042536
TI  - Caring makes the difference. Nursing grand rounds.

PMID- 1042537
TI  - Refining your I.V. therapy techniques.

PMID- 1042538
TI  - Debbie got attention...the hard way.

PMID- 1042539
TI  - What you should know about communicable diseases and their immunizations. A guide
      for nurses in ambulatory settings. Part III. Mumps, chickenpox, and diarrhea.

PMID- 1042540
TI  - Getting control of Wayne.

PMID- 1042542
TI  - Fari's baby.

PMID- 1042541
TI  - Job evaluations: giving and getting them--with less of a hassle.

PMID- 1042543
TI  - Diabetic teaching: how to win your patient's cooperation in his care.

PMID- 1042544
TI  - Rheumatoid arthritis: understanding it more fully.

PMID- 1042545
TI  - Rheumatoid arthritis: managing it more successfully.

PMID- 1042546
TI  - Rheumatoid arthritis: living with it more comfortably.

PMID- 1042548
TI  - The alcoholic employee. How the nurse can help.

PMID- 1042547
TI  - Families in crisis; knowing when and how to help.

PMID- 1042549
TI  - Juggling patients on the head of a pin or how much can a mere mortal do?

PMID- 1042550
TI  - Why not become a diabetes nurse specialist?

PMID- 1042552
TI  - Nursing and poetry don't mix.

PMID- 1042551
TI  - Microbiologic studies: Part 2. Improving your role in blood culture procedures.

PMID- 1042553
TI  - Understanding the extrapyramidal system.

PMID- 1042554
TI  - A "second skin" for patients with large, draining wounds.

PMID- 1042555
TI  - Septic shock in a burn patient. Nursing grand rounds.

PMID- 1042556
TI  - Anticonvulsant drugs and the epileptic's dilemma.

PMID- 1042557
TI  - Standing firm.

PMID- 1042558
TI  - Electricity and electrical safety in the hospital.

PMID- 1042559
TI  - You can prevent suicide.

PMID- 1042560
TI  - Physical examination. Part 13. Examining the abdomen.

PMID- 1042561
TI  - Syphilis and gonorrhea: an update for nurses in ambulatory settings.

PMID- 1042562
TI  - Malpractice; how good is your insurance protection?

PMID- 1042563
TI  - Microbiologic studies: Part 3. The problems with respiratory tract cultures--and
      what you can do about them.

PMID- 1042564
TI  - Tips for improving urine testing techniques.

PMID- 1042565
TI  - Better ways to cope with C.O.P.D.

PMID- 1042566
TI  - Physical examination. Part 14. Male genitalia.

PMID- 1042567
TI  - Guidelines for more effective health teaching.

PMID- 1042568
TI  - Go fight city hall.

PMID- 1042569
TI  - Salvaging an unwilling life. Nursing grand rounds.

PMID- 1042570
TI  - HHNK (hyperglycemic hyperosmolar nonketotic coma); a newly recognized syndrome to
      watch for.

PMID- 1042571
TI  - Proper charting is important.

PMID- 1042572
TI  - The spaghetti theory of leadership (and other saucy ideas).

PMID- 1042573
TI  - The utilization review coordinator--a different kind of nurse.

PMID- 1042574
TI  - Editorial: The OH team at work.

PMID- 1042575
TI  - OH Congress. The information gap.

PMID- 1042576
TI  - OH Congress. The place of OH in the community.

PMID- 1042578
TI  - OH Congress session. Asbestos.

PMID- 1042577
TI  - OH Congress session. Ergonomics.

PMID- 1042579
TI  - OH Congress. Day-release as a scheme of study.

PMID- 1042580
TI  - OH Congress. Stress and the young worker.

PMID- 1042582
TI  - Safety. Splendid isolation.

PMID- 1042581
TI  - Plumbing the shallows.

PMID- 1042583
TI  - Editorial: Vital statistics.

PMID- 1042584
TI  - OH Congress. Hydrofluoric acid burns.

PMID- 1042585
TI  - OH Congress session. Relationship between OH and other services.

PMID- 1042587
TI  - OH Congress session. Shift work.

PMID- 1042586
TI  - OH Congress session. Noise and vibration.

PMID- 1042588
TI  - Burn treatment in Bahrain.

PMID- 1042589
TI  - The age of chivalry?

PMID- 1042591
TI  - Assessment of damages.

PMID- 1042590
TI  - Safety economics.

PMID- 1042592
TI  - Editorial: Opportunity lost.

PMID- 1042593
TI  - A medical record system.

PMID- 1042594
TI  - Local authority OH services.

PMID- 1042595
TI  - Safety. Construction management.

PMID- 1042596
TI  - Winter's scourge.

PMID- 1042598
TI  - Employment Medical Advisory Service (EMAS).

PMID- 1042597
TI  - Safety in space.

PMID- 1042599
TI  - The Permanent Commission.

PMID- 1042600
TI  - Tutorial: health interviews. 7.

PMID- 1042601
TI  - Safety: catering food hygiene.

PMID- 1042602
TI  - Licence to work?

PMID- 1042603
TI  - Pediatric orthopaedic nursing: a tradition and a challenge.

PMID- 1042604
TI  - A ten-minute examination to pinpoint skeletal injuries.

PMID- 1042605
TI  - Nursing care of the orthopedic patient in the operating room.

PMID- 1042606
TI  - Orthopedic nursing action.

PMID- 1042607
TI  - Scoliosis detection.

PMID- 1042608
TI  - Orthopedic nurses start thinking metric.

PMID- 1042609
TI  - Parathyroid adenoma--an orthopedic problem?

PMID- 1042610
TI  - Intravenous regional anesthesia.

PMID- 1042611
TI  - Continuous closed tube irrigation and suction therapy.

PMID- 1042612
TI  - The nonoperative management of scoliosis.

PMID- 1042614
TI  - [Problems of practical education in the nursing profession. 1].

PMID- 1042613
TI  - Articulation of health occupations programs career mobility in Oklahoma
      highschool - practical nursing - associate degree. II.

PMID- 1042615
TI  - [Nursing care in seborrheic eczema].

PMID- 1042616
TI  - [Principles of behavior therapy].

PMID- 1042617
TI  - [Community health nurse; key position in public health nursing].

PMID- 1042618
TI  - [Problems of practical education in the nursing profession. 2].

PMID- 1042619
TI  - [Nursing in diseases of infancy].

PMID- 1042620
TI  - [Psychological aspects of nursing].

PMID- 1042622
TI  - [Multiple sclerosis].

PMID- 1042621
TI  - [Responsibility and nursing].

PMID- 1042623
TI  - [The problem of euthanasia].

PMID- 1042624
TI  - [European Council - Committee for Social and Health Problems].

PMID- 1042625
TI  - [Care plan for patients with tuberculosis].

PMID- 1042626
TI  - [Preparation of patients for electroencephalography].